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\nThe activity of all cells in the nervous system is regulated by the interaction of various chemicals, such as neurotransmitters, hormones, and peptides with membrane receptors. The ways in which these substances exert their influence is known generally as signal transduction. We use the vertebrate olfactory receptor neuron as a model for investigating general principles and mechanisms of signal transduction - receptor-ligand interactions, modulation by second messeng ers, ion channel gating, and the long term mechanisms of adaptation and desensitization. The olfactory neuron is uniquely suited for these studies since it is designed specifically for the detection and discrimination of a wide variety of small organic molecules, i.e. odors. \n

\nFor more information, visit
\nStuart Firestein
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\nThe activity of all cells in the nervous system is regulated by the interaction of various chemicals, such as neurotransmitters, hormones, and peptides with membrane receptors. The ways in which these substances exert their influence is known generally as signal transduction. We use the vertebrate olfactory receptor neuron as a model for investigating general principles and mechanisms of signal transduction - receptor-ligand interactions, modulation by second messeng ers, ion channel gating, and the long term mechanisms of adaptation and desensitization. The olfactory neuron is uniquely suited for these studies since it is designed specifically for the detection and discrimination of a wide variety of small organic molecules, i.e. odors. \n

\nFor more information, visit
\nStuart Firestein
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\nThe activity of all cells in the nervous system is regulated by the interaction of various chemicals, such as neurotransmitters, hormones, and peptides with membrane receptors. The ways in which these substances exert their influence is known generally as signal transduction. We use the vertebrate olfactory receptor neuron as a model for investigating general principles and mechanisms of signal transduction - receptor-ligand interactions, modulation by second messeng ers, ion channel gating, and the long term mechanisms of adaptation and desensitization. The olfactory neuron is uniquely suited for these studies since it is designed specifically for the detection and discrimination of a wide variety of small organic molecules, i.e. odors. \n

\nFor more information, visit
\nStuart Firestein
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