||The main interest of the Bezanilla lab is the search for the molecular basis of voltage sensor operation. This question is being approached with physical techniques such as temperature effects and complex capacitance measurements in the frequency domain, combined with mutations of the channel molecule, and assessed by gating currents, macroscopic currents and single channel recordings. The correlation with structural changes are being monitored with optical techniques using fluorescence changes and fluorescence resonance energy transfer from probes attached to strategic sites in the channel molecule.
NIH Neuroscience Seminar Series
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