NIH VideoCast - The Various Roles of Nanoscale AMPA Receptor Dynamics in Synaptic Plasticity

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The Various Roles of Nanoscale AMPA Receptor Dynamics in Synaptic Plasticity

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Air date:	Monday, February 6, 2017, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 271 (29 Live, 242 On-demand)
Category:	Neuroscience
Runtime:	01:11:49
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Neuroscience Series Robert Newcomb Memorial Seminar Dr. Choquet’s lab has a transdisciplinary approach to study the interplay between the organizational dynamics of the molecular components of glutamatergic synapses and synaptic transmission. Their projects build on their recent findings that: trafficking of neuronal molecules such as glutamate receptors is highly dynamic, regulations of protein-protein interactions play key roles in the control of this trafficking at different steps, including lateral diffusion, endo and exocytosis, modulation of glutamate receptor trafficking has a profound impact on synaptic transmission, including on both short and long term post-synaptic plasticity. By combining the expertise of chemists, biochemists, cell biologists, biophysicists and neurophysiologists, they will develop 3 main research axes: dynamics and physical-chemistry of the macro-molecular complexes of the synapse, nano-scale organization and dynamics of synaptic proteins and membrane trafficking, impact of the dynamic of synapse organization on synaptic physiology. Results obtained in these three axes will be constantly integrated to provide a global view of glutamatergic synapse physiology, from nano-scale interactions to function. For more information go to https://neuroscience.nih.gov/neuroseries/Home.aspx

NLM Title:	The various roles of nanoscale AMPA receptor dynamics in synaptic plasticity / Daniel Choquet.
Author:	Choquet, Daniel. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Neuroscience Series Robert Newcomb Memorial Seminar Dr. Choquet's lab has a transdisciplinary approach to study the interplay between the organizational dynamics of the molecular components of glutamatergic synapses and synaptic transmission. Their projects build on their recent findings that: trafficking of neuronal molecules such as glutamate receptors is highly dynamic, regulations of protein-protein interactions play key roles in the control of this trafficking at different steps, including lateral diffusion, endo and exocytosis, modulation of glutamate receptor trafficking has a profound impact on synaptic transmission, including on both short and long term post-synaptic plasticity. By combining the expertise of chemists, biochemists, cell biologists, biophysicists and neurophysiologists, they will develop 3 main research axes: dynamics and physical-chemistry of the macro-molecular complexes of the synapse, nano-scale organization and dynamics of synaptic proteins and membrane trafficking, impact of the dynamic of synapse organization on synaptic physiology. Results obtained in these three axes will be constantly integrated to provide a global view of glutamatergic synapse physiology, from nano-scale interactions to function.
Subjects:	Molecular Structure Neuronal Plasticity--physiology Protein Transport--physiology Receptors, AMPA--physiology Synapses--physiology Synaptic Transmission--physiology
Publication Types:	Lecture Webcast

NLM Classification:	WL 102.8
NLM ID:	101702159
CIT Live ID:	19836
Permanent link:	https://videocast.nih.gov/watch=19836

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