NIH VideoCast - Where the Tortoise and the Hare Meet - Clathrin and Adaptors in Synaptic Vesicle Cycling

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Where the Tortoise and the Hare Meet - Clathrin and Adaptors in Synaptic Vesicle Cycling

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Air date:	Monday, September 12, 2016, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 230 (28 Live, 202 On-demand)
Category:	Neuroscience
Runtime:	01:00:07
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Neuroscience Series Seminar The focus of research in the Dr. Haucke laboratory is the dissection of the molecular mechanisms of exo-endocytosis and endolyososomal membrane dynamics and its role in cell signaling, especially in the nervous system (Kononnenko & Haucke, Neuron 2015). The laboratory uses a wide range of technologies that include biochemical and molecular biological approaches in vitro, chemical biology and screening technology, super-resolution microscopy as well as genetic manipulations at the organismic level in vivo. The overarching goal of these studies is to provide a mechanistic understanding of exo-endocytosis and endolysosomal membrane dynamics and its regulation by proteins and lipids and to use this know-how to develop novel strategies for acute chemical and pharmacological interference. Research within the Dr. Haucke lab can be grossly divided into two major themes: (1) The role of exo-endocytic and endolysosomal proteins within the brain, especially in the maintenance of neurotransmission at chemical synapses, and (2) The regulation of membrane homeostasis in endocytosis & in the endolysosomal system by phosphoinositides and phosphoinositide metabolizing enzymes. Over the past decade his lab has made significant contributions in both of these areas. For more information go to https://neuroscience.nih.gov/neuroseries/Home

NLM Title:	Where the tortoise and the hare meet : clathrin and adaptors in synaptic vesicle cycling / Volker Haucke.
Author:	Haucke, Volker. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Neuroscience Series Seminar The focus of research in the Dr. Haucke laboratory is the dissection of the molecular mechanisms of exo-endocytosis and endolyososomal membrane dynamics and its role in cell signaling, especially in the nervous system (Kononnenko & Haucke, Neuron 2015). The laboratory uses a wide range of technologies that include biochemical and molecular biological approaches in vitro, chemical biology and screening technology, super-resolution microscopy as well as genetic manipulations at the organismic level in vivo. The overarching goal of these studies is to provide a mechanistic understanding of exo-endocytosis and endolysosomal membrane dynamics and its regulation by proteins and lipids and to use this know-how to develop novel strategies for acute chemical and pharmacological interference. Research within the Dr. Haucke lab can be grossly divided into two major themes: (1) The role of exo-endocytic and endolysosomal proteins within the brain, especially in the maintenance of neurotransmission at chemical synapses, and (2) The regulation of membrane homeostasis in endocytosis & in the endolysosomal system by phosphoinositides and phosphoinositide metabolizing enzymes. Over the past decade his lab has made significant contributions in both of these areas.
Subjects:	Clathrin--physiology Endocytosis--physiology Synaptic Transmission--physiology Synaptic Vesicles--physiology Vesicular Neurotransmitter Transport Proteins--physiology
Publication Types:	Lecture Webcast

NLM Classification:	WL 102.8
NLM ID:	101693820
CIT Live ID:	19667
Permanent link:	https://videocast.nih.gov/watch=19667

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