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Age, genes, sex, and smell: predicting Parkinson disease

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Air date: Wednesday, May 4, 2016, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 551, (170 Live, 381 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:09:50
Description: NIH Director’s Wednesday Afternoon Lecture Series

Florence Mahoney Lecture on Aging

Dr. Singleton's talk will focus on the most effective route to testing disease-modifying therapies in neurodegenerative disease earlier in the disease process, with a particular focus on Parkinson disease. He will discuss attempts to make headway in identifying at-risk patients as early as possible in the disease process, when interventions may be most effective.

Dr. Singleton's lab was the first to identify synuclein gene dosage mutations as a cause of Parkinson disease and the Leucine-rich repeat kinase 2 (LRRK2) gene as a cause of familial Parkinson, as well as the more common, sporadic Parkinson disease. These proteins are now the two leading therapeutic targets for the disease. More recently, his laboratory has focused on the use of high-dimensional data to understand risk and pathogenic function in Parkinson disease and other neurodegenerative disorders.

The annual lecture is given in honor of Florence Mahoney, who was instrumental in advocating for the establishment of an NIH institute devoted to aging research. Ms. Mahoney died in 2002 at the age of 103. For more information on Ms. Mahoney, refer to her obituary in the NIH Record at http://1.usa.gov/1YVTXJt.

For more information go to https://oir.nih.gov/wals
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NLM Title: Age, genes, sex, and smell : predicting Parkinson disease / Andrew Singleton.
Author: Singleton, Andrew.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Dr. Singleton's talk will focus on the most effective route to testing disease-modifying therapies in neurodegenerative disease earlier in the disease process, with a particular focus on Parkinson disease. He will discuss attempts to make headway in identifying at-risk patients as early as possible in the disease process, when interventions may be most effective. Dr. Singleton's lab was the first to identify synuclein gene dosage mutations as a cause of Parkinson disease and the Leucine-rich repeat kinase 2 (LRRK2) gene as a cause of familial Parkinson, as well as the more common, sporadic Parkinson disease. These proteins are now the two leading therapeutic targets for the disease. More recently, his laboratory has focused on the use of high-dimensional data to understand risk and pathogenic function in Parkinson disease and other neurodegenerative disorders.
Subjects: Genetic Predisposition to Disease
Parkinson Disease--etiology
Parkinson Disease--genetics
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: WL 359
NLM ID: 101684393
CIT Live ID: 18967
Permanent link: https://videocast.nih.gov/watch=18967