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\nA pervasive challenge in immunology, and its interface with many disease states, is to control the immune response in an antigen specific way, both positively (protective immunity) and negatively (specific silencing or tolerance). To approach this challenge, it will be valuable to learn to monitor and manipulate dendritic cell function directly in situ. To begin with, antigens can be targeted more selectively to dendritic cells in vivo. This can be achieved through receptors for antigen uptake, as will be illustrated by the delivery of ovalbumin protein conjugated to a monoclonal antibody to DEC-205, an endocytic receptor expressed at high levels by dendritic cells in the T cell areas of lymphoid tissues.

\nFor more information, visit
\nRalph Steinman
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\nA pervasive challenge in immunology, and its interface with many disease states, is to control the immune response in an antigen specific way, both positively (protective immunity) and negatively (specific silencing or tolerance). To approach this challenge, it will be valuable to learn to monitor and manipulate dendritic cell function directly in situ. To begin with, antigens can be targeted more selectively to dendritic cells in vivo. This can be achieved through receptors for antigen uptake, as will be illustrated by the delivery of ovalbumin protein conjugated to a monoclonal antibody to DEC-205, an endocytic receptor expressed at high levels by dendritic cells in the T cell areas of lymphoid tissues.

\nFor more information, visit
\nRalph Steinman
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\nA pervasive challenge in immunology, and its interface with many disease states, is to control the immune response in an antigen specific way, both positively (protective immunity) and negatively (specific silencing or tolerance). To approach this challenge, it will be valuable to learn to monitor and manipulate dendritic cell function directly in situ. To begin with, antigens can be targeted more selectively to dendritic cells in vivo. This can be achieved through receptors for antigen uptake, as will be illustrated by the delivery of ovalbumin protein conjugated to a monoclonal antibody to DEC-205, an endocytic receptor expressed at high levels by dendritic cells in the T cell areas of lymphoid tissues.

\nFor more information, visit
\nRalph Steinman
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