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Biophysics of Protein-Protein Interactions

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Air date: Wednesday, September 18, 2002, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 108 * This only includes stats from October 2011 and forward.
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:00:39
Description: The NIH Director's Wednesday Afternoon Lecture Series

Protein-protein interactions are the key to signal transduction and to many other regulatory processes. When a regulatory protein binds to its target, structural and dynamic changes occur. Our lab uses a combination of experimental approaches to try to obtain an integrated picture of a protein-protein interaction. In the thrombin-thrombomodulin interaction, thrombin, a procoagulant protein, is converted into an anticoagulant protein with different substrate specificity by its interaction with thrombomodulin and this conversion is critical for cessation of blood clotting. Using surface plasmon resonance, we have measured the real-time binding kinetics and binding thermodynamics and have found that the association rate is diffusion controlled and very fast due to electrostatic steering.

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Elizabeth A. Komives
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Author: Elizabeth A. Komives, Ph.D., UCSD
Rights: This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
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CIT Live ID: 1864
Permanent link: https://videocast.nih.gov/watch=1864