NIH VideoCast - Aire: new tricks from an old dog

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Aire: new tricks from an old dog

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Air date:	Wednesday, March 1, 2017, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 391 (55 Live, 336 On-demand)
Category:	Immunology
Runtime:	01:05:34
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Immunology Interest Group Seminar Series Aire is a transcriptional regulator that controls immunological tolerance. Its primary modus operandi is the induction – specifically in thymic medullary epithelial cells – of a battery of transcripts encoding proteins characteristic of terminally differentiated peripheral cell-types, and consequently negative selection of T cells that recognize these proteins. After briefly reviewing the classical findings, this presentation will focus on more recently discovered facets of Aire function, including positive selection of a perinatal population of regulatory T cells, inhibition of the generation of IL-17-producing “early-responder” γ:δ T cell populations, and activation of MEC superenhancers. Dr. Mathis obtained a PhD from the University of Rochester, and performed postdoctoral studies at the Laboratoire de Génétique Moléculaire des Eucaryotes in Strasbourg, France and at Stanford University Medical Center. She returned to Strasbourg at the end of 1983, establishing a laboratory at the LGME [later the Institut de Genetique et de Biologie Moleculare et Cellulaire (IGBMC)] in conjunction with Dr. Christophe Benoist. The lab moved to the Joslin Diabetes Center, Boston in 1999. Through 2008, Dr. Mathis was a Professor of Medicine at Brigham and Women’s Hospital and Harvard Medical School, and Associate Research Director and Head of the Section on Immunology and Immunogenetics at Joslin. Dr. Mathis is currently a Professor in the Department of Microbiology and Immunobiology at HMS, and holder of the Morton Grove-Rasmussen Chair in Immunohematology. She is also an Associate Faculty Member of the Broad Institute. She presently serves on Advisory Boards of the HHMI, Genentech, MedImmune, Pfizer and Amgen (amongst others) and of several research institutes worldwide. Dr. Mathis was elected to the US National Academy of Sciences in 2003, the German Academy in 2007, and the American Academy of Arts and Sciences in 2012. She received the FASEB Excellence in Science Award in 2016. Her lab works in the fields of T cell differentiation, autoimmunity and inflammation. She has trained over 150 students and postdoctoral fellows.

NLM Title:	AIRE : new tricks from an old dog / Diane Mathis.
Author:	Mathis, Diane. National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract:	(CIT): Immunology Interest Group Seminar Series AIRE is a transcriptional regulator that controls immunological tolerance. Its primary modus operandi is the induction - specifically in thymic medullary epithelial cells - of a battery of transcripts encoding proteins characteristic of terminally differentiated peripheral cell-types, and consequently negative selection of T cells that recognize these proteins. Dr. Mathis obtained a PhD from the University of Rochester, and performed postdoctoral studies at the Laboratoire de Genetique Moleculaire des Eucaryotes in Strasbourg, France and at Stanford University Medical Center. She returned to Strasbourg at the end of 1983, establishing a laboratory at the LGME [later the Institut de Genetique et de Biologie Moleculare et Cellulaire (IGBMC)] in conjunction with Dr. Christophe Benoist. The lab moved to the Joslin Diabetes Center, Boston in 1999. Through 2008, Dr. Mathis was a Professor of Medicine at Brigham and Women's Hospital and Harvard Medical School, and Associate Research Director and Head of the Section on Immunology and Immunogenetics at Joslin. Dr. Mathis is currently a Professor in the Department of Microbiology and Immunobiology at HMS, and holder of the Morton Grove-Rasmussen Chair in Immunohematology. She is also an Associate Faculty Member of the Broad Institute. She presently serves on Advisory Boards of the HHMI, Genentech, MedImmune, Pfizer and Amgen (amongst others) and of several research institutes worldwide. Dr. Mathis was elected to the US National Academy of Sciences in 2003, the German Academy in 2007, and the American Academy of Arts and Sciences in 2012. She received the FASEB Excellence in Science Award in 2016. Her lab works in the fields of T cell differentiation, autoimmunity and inflammation. She has trained over 150 students and postdoctoral fellows.
Subjects:	Autoimmunity--physiology Immune Tolerance Transcription Factors
Publication Types:	Lecture Webcast

NLM Classification:	QW 545
NLM ID:	101703950
CIT Live ID:	18556
Permanent link:	https://videocast.nih.gov/watch=18556

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