NIH VideoCast - Development and guidance of cranial motor neurons in health and disease

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Development and guidance of cranial motor neurons in health and disease

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Air date:	Monday, June 6, 2016, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 199 (28 Live, 171 On-demand)
Category:	Neuroscience
Runtime:	01:00:52
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Neuroscience Series Seminar The human brain is a highly organized structure containing myriad axon tracts that follow precise pathways and make predictable connections, yet only a handful of human disorders clearly resulting from errors in axon growth and guidance have been identified. Dr. Engle’s lab has found that human congenital disorders of eye and face movement can result from disordered axon targeting of cranial musculature, leading to the definition of the congenital cranial dysinnervation disorders (CCDDs). Cranial nerve development is a beautifully precise and tractable model system in which to observe axon trajectories, and the disease genes they have identified have led to their interest in the role of the cytoskeleton and the interplay between microtubules and their associated proteins in these processes. Current projects in the lab include (1) the use of genetic technologies to identify genes mutated in the CCDDs and other peripheral and central nervous system developmental disorders, (2) functional studies of these mutated genes and their normal and abnormal proteins using mouse and zebrafish modeling and various in vitro approaches, and (3) studies to better define normal cranial nuclear and nerve development.

NLM Title:	Development and guidance of cranial motor neurons in health and disease / Elizabeth Engle.
Author:	Engle, Elizabeth. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Neuroscience Series Seminar The human brain is a highly organized structure containing myriad axon tracts that follow precise pathways and make predictable connections, yet only a handful of human disorders clearly resulting from errors in axon growth and guidance have been identified. Dr. Engle's lab has found that human congenital disorders of eye and face movement can result from disordered axon targeting of cranial musculature, leading to the definition of the congenital cranial dysinnervation disorders (CCDDs). Cranial nerve development is a beautifully precise and tractable model system in which to observe axon trajectories, and the disease genes they have identified have led to their interest in the role of the cytoskeleton and the interplay between microtubules and their associated proteins in these processes. Current projects in the lab include (1) the use of genetic technologies to identify genes mutated in the CCDDs and other peripheral and central nervous system developmental disorders, (2) functional studies of these mutated genes and their normal and abnormal proteins using mouse and zebrafish modeling and various in vitro approaches, and (3) studies to better define normal cranial nuclear and nerve development.
Subjects:	Motor Neurons--pathology Ocular Motility Disorders--genetics Oculomotor Nerve--physiopathology
Publication Types:	Lecture Webcast

NLM Classification:	WW 410
NLM ID:	101686949
CIT Live ID:	17992
Permanent link:	https://videocast.nih.gov/watch=17992

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