Skip Navigation

NIH VideoCasting

CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable file. CIT can also broadcast NIH-only or HHS-only content.

Development and guidance of cranial motor neurons in health and disease

Loading video...

186 Views  
   
Air date: Monday, June 6, 2016, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 186 (28 Live, 158 On-demand)
Category: Neuroscience
Runtime: 01:00:52
Description: NIH Neuroscience Series Seminar

The human brain is a highly organized structure containing myriad axon tracts that follow precise pathways and make predictable connections, yet only a handful of human disorders clearly resulting from errors in axon growth and guidance have been identified. Dr. Engle’s lab has found that human congenital disorders of eye and face movement can result from disordered axon targeting of cranial musculature, leading to the definition of the congenital cranial dysinnervation disorders (CCDDs). Cranial nerve development is a beautifully precise and tractable model system in which to observe axon trajectories, and the disease genes they have identified have led to their interest in the role of the cytoskeleton and the interplay between microtubules and their associated proteins in these processes.

Current projects in the lab include (1) the use of genetic technologies to identify genes mutated in the CCDDs and other peripheral and central nervous system developmental disorders, (2) functional studies of these mutated genes and their normal and abnormal proteins using mouse and zebrafish modeling and various in vitro approaches, and (3) studies to better define normal cranial nuclear and nerve development.
Debug: Show Debug
NLM Title: Development and guidance of cranial motor neurons in health and disease / Elizabeth Engle.
Author: Engle, Elizabeth.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Neuroscience Series Seminar The human brain is a highly organized structure containing myriad axon tracts that follow precise pathways and make predictable connections, yet only a handful of human disorders clearly resulting from errors in axon growth and guidance have been identified. Dr. Engle's lab has found that human congenital disorders of eye and face movement can result from disordered axon targeting of cranial musculature, leading to the definition of the congenital cranial dysinnervation disorders (CCDDs). Cranial nerve development is a beautifully precise and tractable model system in which to observe axon trajectories, and the disease genes they have identified have led to their interest in the role of the cytoskeleton and the interplay between microtubules and their associated proteins in these processes. Current projects in the lab include (1) the use of genetic technologies to identify genes mutated in the CCDDs and other peripheral and central nervous system developmental disorders, (2) functional studies of these mutated genes and their normal and abnormal proteins using mouse and zebrafish modeling and various in vitro approaches, and (3) studies to better define normal cranial nuclear and nerve development.
Subjects: Motor Neurons--pathology
Ocular Motility Disorders--genetics
Oculomotor Nerve--physiopathology
Publication Types: Lecture
Webcast
Download: To download this event, select one of the available bitrates:
[64k]  [150k]  [240k]  [440k]  [740k]  [1040k]  [1240k]  [1440k]  [1840k]    How to download a Videocast
Caption Text: Download Caption File
NLM Classification: WW 410
NLM ID: 101686949
CIT Live ID: 17992
Permanent link: https://videocast.nih.gov/watch=17992