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The 3D genome organization and long-range control of gene expression

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Air date: Wednesday, February 3, 2016, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 565, (227 Live, 338 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:00:35
Description: NIH Director’s Wednesday Afternoon Lecture Series

The 3-dimensional (3D) genome organization plays an essential role in orchestrating many essential nuclear processes, including DNA replication, transcription, and repair of DNA damages. Great strides have been made recently in the study of 3D chromatin architecture in mammalian cells, with the development of technologies for genome-wide analysis of chromatin interactions at increasing precision and concepts such as "chromosome territories," "topologically associating domains," and "chromatin loops". For his lecture, Dr. Ren will discuss how these advances are transforming the study of gene regulatory mechanisms in mammalian cells. He will give specific examples that illustrate the role of 3D chromatin organization in developing revolutionary tools in sequencing diploid genomes; elucidate the molecular basis of genetic disorders caused by genome structural variations; and offer a functional characterization of enhancers, a class of gene regulatory sequences that can activate target genes at a large genomic distance. The dysfunction of enhancers has been implicated in the etiology of cancer, diabetes, and a broad spectrum of other human diseases.

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NLM Title: The 3D genome organization and long-range control of gene expression / Bing Ren.
Author: Ren, Bing.
National Institutes of Health (U.S.)
Publisher:
Abstract: (CIT): NIH Director's Wednesday Afternoon Lecture Series The 3-dimensional (3D) genome organization plays an essential role in orchestrating many essential nuclear processes, including DNA replication, transcription, and repair of DNA damages. Great strides have been made recently in the study of 3D chromatin architecture in mammalian cells, with the development of technologies for genome-wide analysis of chromatin interactions at increasing precision and concepts such as "chromosome territories," "topologically associating domains," and "chromatin loops". For his lecture, Dr. Ren will discuss how these advances are transforming the study of gene regulatory mechanisms in mammalian cells. He will give specific examples that illustrate the role of 3D chromatin organization in developing revolutionary tools in sequencing diploid genomes; elucidate the molecular basis of genetic disorders caused by genome structural variations; and offer a functional characterization of enhancers, a class of gene regulatory sequences that can activate target genes at a large genomic distance. The dysfunction of enhancers has been implicated in the etiology of cancer, diabetes, and a broad spectrum of other human diseases.
Subjects: Chromatin--genetics
Gene Expression Regulation
Genome
Sequence Analysis, DNA
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: QU 56
NLM ID: 101678401
CIT Live ID: 17836
Permanent link: https://videocast.nih.gov/watch=17836