NIH VideoCast - Somatic Hypermutation by Error-prone DNA Polymerases

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Somatic Hypermutation by Error-prone DNA Polymerases

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Air date:	Wednesday, December 2, 2015, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 212 (22 Live, 190 On-demand)
Category:	Immunology
Runtime:	00:55:48
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Immunology Interest Group Patricia Gearhart started her independent career at the Carnegie Institution of Washington and progressed to the Johns Hopkins University where she was one of the pre-eminent faculty of the Immunology Graduate Program. In 1996 she joined the NIH and moved to the National Institute on Aging, Baltimore Bayview campus. Her laboratory has focused on antibody diversity. Beginning with understanding how the B-cell repertoire is shaped, her work evolved towards understanding the mechanisms of antibody refinement in the germinal center: somatic hypermutation and class switch recombination. Her lab’s specific focus is to understand the mechanisms that direct activation-induced deaminase (AID) and various specialized DNA polymerases to the immunoglobulin loci to initiate the storm of mutations and DNA breaks that create antibody diversity. A fundamental understanding of these processes is critical to understanding the adaptive immune response, and the diseases that arise when these processes are dis-regulated. Pat always has great science to share. She is a broad and innovative thinker and excellent speaker. Even if B cells are not your ‘thing’, Don’t miss this talk.

NLM Title:	Somatic hypermutation by error-prone DNA polymerases / Patricia J. Gearhart.
Author:	Gearhart, P J. National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract:	(CIT): Immunology Interest Group Patricia Gearhart started her independent career at the Carnegie Institution of Washington and progressed to the Johns Hopkins University where she was one of the pre-eminent faculty of the Immunology Graduate Program. In 1996 she joined the NIH and moved to the National Institute on Aging, Baltimore Bayview campus. Her laboratory has focused on antibody diversity. Beginning with understanding how the B-cell repertoire is shaped, her work evolved towards understanding the mechanisms of antibody refinement in the germinal center: somatic hypermutation and class switch recombination. Her lab"s specific focus is to understand the mechanisms that direct activation-induced deaminase (AID) and various specialized DNA polymerases to the immunoglobulin loci to initiate the storm of mutations and DNA breaks that create antibody diversity. A fundamental understanding of these processes is critical to understanding the adaptive immune response, and the diseases that arise when these processes are dis-regulated. Pat always has great science to share. She is a broad and innovative thinker and excellent speaker. Even if B cells are not your "thing", Don"t miss this talk.
Subjects:	DNA-Directed DNA Polymerase--physiology Somatic Hypermutation, Immunoglobulin--genetics
Publication Types:	Lecture Webcast

NLM Classification:	QU 475
NLM ID:	101674293
CIT Live ID:	17729
Permanent link:	https://videocast.nih.gov/watch=17729

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