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Peripheral immune system in health and disease of the brain

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Air date: Monday, February 1, 2016, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 379 (51 Live, 328 On-demand)
Category: Neuroscience
Runtime: 01:04:42
Description: NIH Neuroscience Seminar Series

In Dr. Kipnis lab they are working to better understand the complex interactions between the immune and nervous systems. Until very recently, scientists assumed that any activity of the immune system within or around the central nervous system (CNS) was a hallmark of pathology. However, multiple new lines of evidence support the notion that immune support is actually required for optimal neuronal survival following CNS injury. In parallel, they recently showed that immune-compromised mice exhibit behavioral and cognitive abnormalities when compared to mice with normally-functioning immune systems. Animals that lack the population of unique T lymphocytes, or key molecular factors produced by these cells, are strikingly impaired in learning and memory tasks, adult neurogenesis, and neuronal plasticity. Moreover, a well-controlled boost of immune response improves learning abilities in normal animals and accelerates the process of neurogenesis. Their goal is to elucidate the cellular and molecular mechanisms underlying the beneficial effects of immune cells in healthy and diseased CNS. On the therapeutic “frontline”, they are designing vaccines and developing novel therapies with a potential to promote neuronal survival, improve cognitive functions, and slow down progression of neurodegenerative, neurodevelopmental and cognitive disorders.
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NLM Title: Peripheral immune system in health and disease of the brain / Jonathan Kipnis.
Author: Kipnis, Jonathan.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Neuroscience Seminar Series In Dr. Kipnis lab they are working to better understand the complex interactions between the immune and nervous systems. Until very recently, scientists assumed that any activity of the immune system within or around the central nervous system (CNS) was a hallmark of pathology. However, multiple new lines of evidence support the notion that immune support is actually required for optimal neuronal survival following CNS injury. In parallel, they recently showed that immune-compromised mice exhibit behavioral and cognitive abnormalities when compared to mice with normally-functioning immune systems. Animals that lack the population of unique T lymphocytes, or key molecular factors produced by these cells, are strikingly impaired in learning and memory tasks, adult neurogenesis, and neuronal plasticity. Moreover, a well-controlled boost of immune response improves learning abilities in normal animals and accelerates the process of neurogenesis. Their goal is to elucidate the cellular and molecular mechanisms underlying the beneficial effects of immune cells in healthy and diseased CNS. On the therapeutic "frontline", they are designing vaccines and developing novel therapies with a potential to promote neuronal survival, improve cognitive functions, and slow down progression of neurodegenerative, neurodevelopmental and cognitive disorders.
Subjects: Brain Diseases--immunology
Central Nervous System--physiology
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: WL 348
NLM ID: 101678398
CIT Live ID: 17437
Permanent link: https://videocast.nih.gov/watch=17437