NIH VideoCast - Thymocyte: stromal cell crosstalk governing normal and neoplastic T cell development

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Thymocyte: stromal cell crosstalk governing normal and neoplastic T cell development

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Air date:	Wednesday, May 20, 2015, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 225 (28 Live, 197 On-demand)
Category:	Immunology
Runtime:	01:05:24
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Immunology Interest Group During her graduate work in Mark Davis's lab at Stanford University, Lauren Ehrlich's studies focused on elucidating the spatial and temporal recruitment of TCR-proximal signaling molecules to Immunological synapses of developing T cells undergoing negative selection and mature T cells undergoing activation. Her seminal publications on this work (Immunity, 16:595-606;2002 and Immunity, 17:809-822; 2001) were the first reports of immune synapse formation during thymocyte maturation and showed that the synapses formed in the thymus differ qualitatively from those generated after mature T cell activation. During her postdoctoral time in Irv Weissman's lab at Stanford, Lauren developed a live 2-photon imaging approach to visualize the migration of purified thymocyte subsets throughout all regions of the thymus. This approach enabled her studies demonstrating that only the most mature thymocytes have the capacity to migrate within the medulla, and GPCR signals beyond CCR7 were required for thymocyte medullary entry (Immunity, 31:986-998; 2009). She also carried out a series of studies demonstrating that common lymphoid progenitors are lymphoid committed in vivo and are the most immediate BM precursors that initate thymopoiesis. Since starting her own lab at The University of Texas at Austin, Lauren has continued to pursue her interest in the contribution of thymocyte:stromal interactions to differentiation of a diverse, non-autoreactive T cell pool. She has also begun to investigate the importance of thymocyte/stromal interactions in mouse models of T cell acute lymphoblastic leukemia (T-ALL). These studies have yielded the striking findings that the thymic microenvironment is dramatically altered in T-ALL, and that the changes in thymus stromal composition are critical for tumor maintenance and growth. Lauren's results, which have clear translational relevance in addition to providing new insights into T cell developmental biology are of broad interest to the immunology community. For more information go to http://sigs.nih.gov/immunology/Pages/default.aspx

NLM Title:	Thymocyte : stromal cell crosstalk governing normal and neoplastic T cell development / Lauren Ehrlich ; Immunology Interest Group.
Author:	Ehrlich, Lauren. National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract:	(CIT): Immunology Interest Group During her graduate work in Mark Davis's lab at Stanford University, Lauren Ehrlich's studies focused on elucidating the spatial and temporal recruitment of TCR-proximal signaling molecules to Immunological synapses of developing T cells undergoing negative selection and mature T cells undergoing activation. Her seminal publications on this work (Immunity, 16:595-606;2002 and Immunity, 17:809-822; 2001) were the first reports of immune synapse formation during thymocyte maturation and showed that the synapses formed in the thymus differ qualitatively from those generated after mature T cell activation. During her postdoctoral time in Irv Weissman's lab at Stanford, Lauren developed a live 2-photon imaging approach to visualize the migration of purified thymocyte subsets throughout all regions of the thymus. This approach enabled her studies demonstrating that only the most mature thymocytes have the capacity to migrate within the medulla, and GPCR signals beyond CCR7 were required for thymocyte medullary entry (Immunity, 31:986-998; 2009). She also carried out a series of studies demonstrating that common lymphoid progenitors are lymphoid committed in vivo and are the most immediate BM precursors that initate thymopoiesis. Since starting her own lab at The University of Texas at Austin, Lauren has continued to pursue her interest in the contribution of thymocyte:stromal interactions to differentiation of a diverse, non-autoreactive T cell pool. She has also begun to investigate the importance of thymocyte/stromal interactions in mouse models of T cell acute lymphoblastic leukemia (T-ALL). These studies have yielded the striking findings that the thymic microenvironment is dramatically altered in T-ALL, and that the changes in thymus stromal composition are critical for tumor maintenance and growth. Lauren's results, which have clear translational relevance in addition to providing new insights into T cell developmental biology are of broad interest to the immunology community.
Subjects:	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Stromal Cells Thymocytes
Publication Types:	Lecture Webcast

NLM Classification:	WH 200
NLM ID:	101660641
CIT Live ID:	16359
Permanent link:	https://videocast.nih.gov/watch=16359

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