NIH VideoCast - Tuning cell-surface receptor signaling through structure-based ligand engineering: Wnt/Frizzled and IgSF proteins

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Tuning cell-surface receptor signaling through structure-based ligand engineering: Wnt/Frizzled and IgSF proteins

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Air date:	Wednesday, November 5, 2014, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 362 (123 Live, 239 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:56:28
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Wednesday Afternoon Lecture Series Dr. Garcia's laboratory investigates the structural and functional aspects of cell-surface receptor recognition and activation in receptor-ligand systems with relevance to human health and disease. Structural information is exploited to understand the mechanisms of ligand recognition and signaling, as well as to inform engineering efforts to manipulate receptor signaling and generate therapeutics. The receptor systems studied derive principally from the immune system (TCR/MHC, cytokines), but additionally encompass several systems that are also important in neurobiology (Semaphorins) and development (Wnt, Notch). A major focus of the lab is on "shared" pleiotropic receptors, to understand the biophysical basis by which different cross-reactive ligands and receptors can elicit unique intracellular responses and functional outcomes. A recent effort in the lab has been to "deorphanize" cell surface receptors, the vast majority of which remain un-paired with a known ligand. In Dr. Garcia's seminar, he will discuss two new projects that focus on systems that exhibit properties of receptor-ligand pleiotropy: 1) Deconvoluting the cross-reactivity of Wnt interactions with Frizzled receptors, and 2) Identification of a new family of Immunoglobulin receptors and ligands that mediate cell-cell adhesion in neuronal structures. For more information go to http://wals.od.nih.gov

NLM Title:	Tuning cell-surface receptor signaling through structure-based ligand engineering : Wnt/Frizzled and IgSF proteins / Christopher Garcia.
Author:	Garcia, K Christopher. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Dr. Garcia's laboratory investigates the structural and functional aspects of cell-surface receptor recognition and activation in receptor-ligand systems with relevance to human health and disease. Structural information is exploited to understand the mechanisms of ligand recognition and signaling, as well as to inform engineering efforts to manipulate receptor signaling and generate therapeutics. The receptor systems studied derive principally from the immune system (TCR/MHC, cytokines), but additionally encompass several systems that are also important in neurobiology (Semaphorins) and development (Wnt, Notch). A major focus of the lab is on "shared" pleiotropic receptors, to understand the biophysical basis by which different cross-reactive ligands and receptors can elicit unique intracellular responses and functional outcomes. A recent effort in the lab has been to "deorphanize" cell surface receptors, the vast majority of which remain un-paired with a known ligand. In Dr. Garcia's seminar, he will discuss two new projects that focus on systems that exhibit properties of receptor-ligand pleiotropy: 1) Deconvoluting the cross-reactivity of Wnt interactions with Frizzled receptors, and 2) Identification of a new family of Immunoglobulin receptors and ligands that mediate cell-cell adhesion in neuronal structures.
Subjects:	Ligands Receptors, Cell Surface--physiology Signal Transduction
Publication Types:	Lecture Webcast

NLM Classification:	QU 55.7
NLM ID:	101647956
CIT Live ID:	15130
Permanent link:	https://videocast.nih.gov/watch=15130

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