NIH VideoCast - Epigenetics in Learning and Memory

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Epigenetics in Learning and Memory

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Air date:	Friday, March 13, 2015, 2:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 589 (129 Live, 460 On-demand)
Category:	BSSR - Behavioral and Social Sciences
Runtime:	01:13:35
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	BSSR Lecture Series The NIH Office of Behavioral and Social Science Research presents the lecture Epigenetic mechanisms in memory formation by Dr. J. David Sweatt, University of Alabama at Birmingham. Dr. Sweatt’s presentation is part of the 2014-2015 Behavioral and Social Sciences Research Lecture Series to promote open and engaged discussion about cutting edge research in the behavioral and social sciences field. Regulation of chromatin structure and control of direct methylation of DNA are the principal mechanisms of epigenetic regulation. This presentation will address the idea that conservation of epigenetic mechanisms for information storage represents a unifying model in biology, with epigenetic mechanisms being utilized for cellular memory at levels from behavioral memory to development to cellular differentiation. Do epigenetic mechanisms operate in behavioral memory formation, including reward-based learning? We have generated several lines of evidence that support this idea that I will discuss. 1. Contextual fear conditioning and reward conditioning trigger alterations in hippocampal DNA methylation and histone post-translational modifications. 2. Inhibitors of DNA methylation block both hippocampal LTP and associative learning in vivo. 3. Remote contextual fear memory is associated with persisting changes in DNA methylation in the Anterior Cingulate Cortex, and DNMT inhibition can reverse established remote memory. 4. Histone acetylation increases in memory formation, and histone deacetylase (HDAC) inhibitors enhance both memory formation and hippocampal long-term potentiation. 5. Histone subunit exchange controls long-term and remote memory stabilization for threat learning. For more information go to http://obssr.od.nih.gov

NLM Title:	Epigenetics in learning and memory / J. David Sweatt.
Author:	Sweatt, J David. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): The NIH Office of Behavioral and Social Science Research presents the lecture Epigenetic mechanisms in memory formation by Dr. J. David Sweatt, University of Alabama at Birmingham. Dr. Sweatt's presentation is part of the 2014-2015 Behavioral and Social Sciences Research Lecture Series to promote open and engaged discussion about cutting edge research in the behavioral and social sciences field. Regulation of chromatin structure and control of direct methylation of DNA are the principal mechanisms of epigenetic regulation. This presentation will address the idea that conservation of epigenetic mechanisms for information storage represents a unifying model in biology, with epigenetic mechanisms being utilized for cellular memory at levels from behavioral memory to development to cellular differentiation. Do epigenetic mechanisms operate in behavioral memory formation, including reward-based learning? We have generated several lines of evidence that support this idea that I will discuss. 1. Contextual fear conditioning and reward conditioning trigger alterations in hippocampal DNA methylation and histone post-translational modifications. 2. Inhibitors of DNA methylation block both hippocampal LTP and associative learning in vivo. 3. Remote contextual fear memory is associated with persisting changes in DNA methylation in the Anterior Cingulate Cortex, and DNMT inhibition can reverse established remote memory. 4. Histone acetylation increases in memory formation, and histone deacetylase (HDAC) inhibitors enhance both memory formation and hippocampal long-term potentiation. 5. Histone subunit exchange controls long-term and remote memory stabilization for threat learning.
Subjects:	Epigenesis, Genetic Learning--physiology Memory--physiology
Publication Types:	Lecture Webcast

NLM Classification:	WL 337
NLM ID:	101655821
CIT Live ID:	14973
Permanent link:	https://videocast.nih.gov/watch=14973

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