NIH VideoCast - How Sweet it is: Essential Roles for Protein O-Glycosylation During Development

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How Sweet it is: Essential Roles for Protein O-Glycosylation During Development

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Air date:	Friday, May 2, 2014, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 251 (40 Live, 211 On-demand)
Category:	NIH Director's Seminars
Runtime:	00:52:06
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director's Seminar Series Cells of the body are decorated with a variety of carbohydrates, or glycans, that serve many diverse functions. These glycans not only act as a protective barrier on the outside of the cell, but are also involved in cellular communication and signaling events. Dr. Ten Hagen’s research program seeks to understand the roles of one type of glycan addition (O-glycosylation) during eukaryotic development. Her group has discovered that this essential protein modification affects secretion, influencing matrix composition, cell adhesion and conserved signaling pathways. Most recently, they have identified how O-glycosylation influences polarized secretion and secretory vesicle formation, providing insight into how aberrations in this protein modification may contribute to disease susceptibility and progression.

NLM Title:	How sweet it is : essential roles for protein O-glycosylation during development / Dr. Kelly G. Ten Hagen.
Author:	Ten Hagen, Kelly G. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Cells of the body are decorated with a variety of carbohydrates, or glycans, that serve many diverse functions. These glycans not only act as a protective barrier on the outside of the cell, but are also involved in cellular communication and signaling events. Dr. Ten Hagen's research program seeks to understand the roles of one type of glycan addition (O-glycosylation) during eukaryotic development. Her group has discovered that this essential protein modification affects secretion, influencing matrix composition, cell adhesion and conserved signaling pathways. Most recently, they have identified how O-glycosylation influences polarized secretion and secretory vesicle formation, providing insight into how aberrations in this protein modification may contribute to disease susceptibility and progression.
Subjects:	Eukaryotic Cells--physiology Glycoproteins--metabolism Glycosylation Protein Processing, Post-Translational--physiology
Publication Types:	Lecture Webcast

NLM Classification:	QU 55.5
NLM ID:	101634126
CIT Live ID:	14100
Permanent link:	https://videocast.nih.gov/watch=14100

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