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The Vertebrate Blueprint of the Motor System - From Forebrain to Spinal Cord

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Air date: Monday, May 12, 2014, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 326 (29 Live, 297 On-demand)
Category: Neuroscience
Runtime: 01:07:24
Description: Neuroscience Seminar Series

The goal of Prof. Grillner’s laboratory is to understand the intrinsic function of the neuronal networks underlying steering, locomotion and posture - from ion channels to motor behavior. Concentration is on the cellular bases of motor behavior with a focus on the mechanisms underlying selection of behavior and the neural bases of locomotion and posture. This in turn requires a detailed knowledge of which nerve cells take part, how they talk to each other through synaptic interaction and an understanding of the intrinsic function of these networks. The properties of the nerve cells within the network can vary greatly and are determined by the palette of ion channels expressed and also other gene products. The lamprey is the preferred model organism, but mammalian models are also used such studies as those on posture.

Grillner’s Lab has been able to successfully model, based on detailed cellular knowledge, the networks responsible for the command and pattern generating systems for locomotion including steering and posture. The work continues with several foci including the role of the basal ganglia for selection of different patterns of motor behaviour, tectum for steering and eye motor coordination, the physiological role of different modulator systems acting through the spinal networks, and different ion channel subtypes contributing to neuronal function. /630.
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NLM Title: The vertebrate blueprint of the motor system : from forebrain to spinal cord / Sten Grillner.
Author: Grillner, Sten.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Neuroscience Seminar Series The goal of Prof. Grillner"s laboratory is to understand the intrinsic function of the neuronal networks underlying steering, locomotion and posture - from ion channels to motor behavior. Concentration is on the cellular bases of motor behavior with a focus on the mechanisms underlying selection of behavior and the neural bases of locomotion and posture. This in turn requires a detailed knowledge of which nerve cells take part, how they talk to each other through synaptic interaction and an understanding of the intrinsic function of these networks. The properties of the nerve cells within the network can vary greatly and are determined by the palette of ion channels expressed and also other gene products. The lamprey is the preferred model organism, but mammalian models are also used such studies as those on posture. Grillner"s Lab has been able to successfully model, based on detailed cellular knowledge, the networks responsible for the command and pattern generating systems for locomotion including steering and posture. The work continues with several foci including the role of the basal ganglia for selection of different patterns of motor behaviour, tectum for steering and eye motor coordination, the physiological role of different modulator systems acting through the spinal networks, and different ion channel subtypes contributing to neuronal function.
Subjects: Motor Neurons
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: WL 102.7
NLM ID: 101634134
CIT Live ID: 14000
Permanent link: https://videocast.nih.gov/watch=14000