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Phasic Dopamine Signals Reward Prediction Errors (Sometimes): Right for the Wrong Reasons

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Air date: Monday, February 10, 2014, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 396 (32 Live, 364 On-demand)
Category: Neuroscience
Runtime: 01:07:06
Description: Neuroscience Seminar Series

Dr. Redgrave's Lab research philosophy assumes that to diagnose and correct what has gone wrong in a complicated system, it is helpful to have a good understanding of its normal function. Consequently, as a prelude to the development of more effective treatments for diseases associated with basal ganglia dysfunction (including Parkinson's disease, schizophrenia, Tourette's syndrome, obsessive compulsive disorder, attention deficit disorder and the many forms of addiction) their research is part of the research effort to elucidate normal functions of the basal ganglia. Along with the cerebellum, cortex and hippocampus, the basal ganglia constitute one of the brain's principal processing units. Common to all is a repeating internal micro-architecture that receives input from, and provides output to functionally diverse regions of the brain. An understanding of the computational processes performed by the basal ganglia on one of its functional inputs is therefore likely to provide profound insights into how inputs from other functional systems are treated.

Thus, they have chosen to investigate how a subcortical sensorimotor structure, the superior colliculus, interacts with the basal ganglia. The superior colliculus was selected because it is one of the few brain structures whose function is comparatively well understood. It is responsible for generating the gaze-shift which brings an unexpected event onto the retinal fovea for more detailed analysis. If they can appreciate exactly how the basal ganglia contribute to this function they are likely to have a much clearer idea of what the basal ganglia do more generally. They use a wide range of anatomical, electrophysiological, electrochemical, pharmacological and behavioural techniques to investigate the functional architecture of the circuitry through which the superior colliculus and basal ganglia interact. This information is used to constrain the computational models of these circuits that have been constructed by their computational neuroscience collaborators within the Department in Sheffield, notably, Kevin Gurney and Tony Prescott. In the near future they intend to include the expertise they have in functional imaging within the Department to augment our systems analysis of basal ganglia function.
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NLM Title: Phasic dopamine signals reward prediction errors (sometimes) : right for the wrong reasons / Peter Redgrave.
Author: Redgrave, Peter.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Dr. Redgrave's Lab research philosophy assumes that to diagnose and correct what has gone wrong in a complicated system, it is helpful to have a good understanding of its normal function. Consequently, as a prelude to the development of more effective treatments for diseases associated with basal ganglia dysfunction (including Parkinson's disease, schizophrenia, Tourette's syndrome, obsessive compulsive disorder, attention deficit disorder and the many forms of addiction) their research is part of the research effort to elucidate normal functions of the basal ganglia. Along with the cerebellum, cortex and hippocampus, the basal ganglia constitute one of the brain's principal processing units. Common to all is a repeating internal micro-architecture that receives input from, and provides output to functionally diverse regions of the brain. An understanding of the computational processes performed by the basal ganglia on one of its functional inputs is therefore likely to provide profound insights into how inputs from other functional systems are treated. Thus, they have chosen to investigate how a subcortical sensorimotor structure, the superior colliculus, interacts with the basal ganglia. The superior colliculus was selected because it is one of the few brain structures whose function is comparatively well understood. It is responsible for generating the gaze-shift which brings an unexpected event onto the retinal fovea for more detailed analysis. If they can appreciate exactly how the basal ganglia contribute to this function they are likely to have a much clearer idea of what the basal ganglia do more generally. They use a wide range of anatomical, electrophysiological, electrochemical, pharmacological and behavioural techniques to investigate the functional architecture of the circuitry through which the superior colliculus and basal ganglia interact. This information is used to constrain the computational models of these circuits that have been constructed by their computational neuroscience collaborators within the Department in Sheffield, notably, Kevin Gurney and Tony Prescott. In the near future they intend to include the expertise they have in functional imaging within the Department to augment our systems analysis of basal ganglia function.
Subjects: Basal Ganglia Diseases--diagnosis
Basal Ganglia--physiology
Dopamine--physiology
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: WK 725
NLM ID: 101628102
CIT Live ID: 13682
Permanent link: https://videocast.nih.gov/watch=13682