Skip Navigation

NIH VideoCasting

CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable file. CIT can also broadcast NIH-only or HHS-only content.

State-Dependent Inhibition in the Cortex

Loading video...

371 Views  
   
Air date: Monday, January 27, 2014, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 371 (37 Live, 334 On-demand)
Category: Neuroscience
Runtime: 00:54:17
Description: Neuroscience Seminar Series

The cortex is made up of interconnected networks containing many different classes of neurons, whose roles in both normal brain activity and disease are poorly understood. Each neuron contributes to activity in the surrounding local network and receives a constant barrage of network synaptic input in return. The Cardin lab investigates this dynamic and bidirectional relationship between neuron and network at multiple levels, including cellular and synaptic mechanisms, network interactions, and behavior. They use a variety of techniques in rodent visual cortex, including intracellular and extracellular recordings in vivo, chronic recordings in awake behaving animals, and optogenetic manipulations of neural activity. A main goal of work in the laboratory is to identify and understand synaptic interactions between excitatory and inhibitory neurons during sensory processing. One ongoing focus is the cellular mechanisms of visual gain control and how gain modulation regulates visual perception. A second focus is to understand the flow of signals between cortical layers and how that process is affected by recruitment of local inhibitory interneurons. They are also interested in how interactions between different classes of neurons change in disease states such as epilepsy and schizophrenia.
Debug: Show Debug
NLM Title: State-dependent inhibition in the cortex / Jessica Cardin.
Author: Cardin, Jessica.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): The cortex is made up of interconnected networks containing many different classes of neurons, whose roles in both normal brain activity and disease are poorly understood. Each neuron contributes to activity in the surrounding local network and receives a constant barrage of network synaptic input in return. The Cardin lab investigates this dynamic and bidirectional relationship between neuron and network at multiple levels, including cellular and synaptic mechanisms, network interactions, and behavior. They use a variety of techniques in rodent visual cortex, including intracellular and extracellular recordings in vivo, chronic recordings in awake behaving animals, and optogenetic manipulations of neural activity. A main goal of work in the laboratory is to identify and understand synaptic interactions between excitatory and inhibitory neurons during sensory processing. One ongoing focus is the cellular mechanisms of visual gain control and how gain modulation regulates visual perception. A second focus is to understand the flow of signals between cortical layers and how that process is affected by recruitment of local inhibitory interneurons. They are also interested in how interactions between different classes of neurons change in disease states such as epilepsy and schizophrenia.
Subjects: Mice--physiology
Neural Inhibition--physiology
Synaptic Transmission--physiology
Visual Cortex--physiology
Visual Perception--physiology
Publication Types: Lecture
Webcast
Download: To download this event, select one of the available bitrates:
[64k]  [150k]  [240k]  [440k]  [740k]  [1040k]    How to download a Videocast
Caption Text: Download Caption File
NLM Classification: WL 102.8
NLM ID: 101624782
CIT Live ID: 13598
Permanent link: https://videocast.nih.gov/watch=13598