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Carving out a Niche for Stem Cells

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Air date: Wednesday, January 15, 2014, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 443, (175 Live, 268 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:04:50
Description: Wednesday Afternoon Lecture Series

Typically, the genetic cause of a disease is identified by studying the DNA of affected individuals, finding the responsible gene, and trying to understand how a mutated version might have coded for a defective protein that led to the disease. Dr. Fuchs, however, has pioneered "reverse genetics": She starts with the protein abnormality and works backwards to identify the human disease. She has applied this strategy to elucidate the genetic basis of a number of blistering skin disorders and tumors. In this lecture she will focus on stem cells, the long-lived cells of our body that allow tissues to replace dying cells and repair wounds. Using skin as a model, she will explore the unique properties of skin stem cells that allow them to both replenish themselves (self-renew) and also maintain and regenerate the epidermis and its appendages such as sweat glands and hair follicles. She will also relay how resident stem cells of the skin communicate and respond to their local neighbors (their "niche"); how these signals prompt them to adjust their program of gene expression and begin to make tissue; and how new signals instruct them when to stop once enough tissue has been made.

For more information go to http://wals.od.nih.gov
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NLM Title: Carving out a niche for stem cells / Elaine Fuchs.
Author: Fuchs, Elaine.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Wednesday Afternoon Lecture Series. Typically, the genetic cause of a disease is identified by studying the DNA of affected individuals, finding the responsible gene, and trying to understand how a mutated version might have coded for a defective protein that led to the disease. Dr. Fuchs, however, has pioneered "reverse genetics": She starts with the protein abnormality and works backwards to identify the human disease. She has applied this strategy to elucidate the genetic basis of a number of blistering skin disorders and tumors. In this lecture she will focus on stem cells, the long-lived cells of our body that allow tissues to replace dying cells and repair wounds. Using skin as a model, she will explore the unique properties of skin stem cells that allow them to both replenish themselves (self-renew) and also maintain and regenerate the epidermis and its appendages such as sweat glands and hair follicles. She will also relay how resident stem cells of the skin communicate and respond to their local neighbors (their "niche"); how these signals prompt them to adjust their program of gene expression and begin to make tissue; and how new signals instruct them when to stop once enough tissue has been made.
Subjects: Epidermis--physiology
Regeneration
Skin Diseases--genetics
Skin--cytology
Stem Cells
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: WR 101
NLM ID: 101624777
CIT Live ID: 13556
Permanent link: https://videocast.nih.gov/watch=13556