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Roles for Transcriptional Super-Enhancers in Cell Identity and Disease

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Air date: Thursday, November 21, 2013, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 871 (143 Live, 728 On-demand)
Category: Special
Runtime: 01:03:38
Description: NHGRI DIR Genome Seminar

The Young laboratory studies super-enhancers (also known as stretch enhancers), which are large clusters of transcriptional enhancers that drive high-level expression of key cell identity genes. For many diseases, trait-associated sequence variation is especially enriched in the super-enhancers of disease-relevant cell types. Furthermore, the Young lab has found that cancer cells acquire super-enhancers at oncogenes and other genes important to tumor pathogenesis. In tumor cells, super-enhancer-driven oncogene expression can be exceptionally vulnerable to drugs that target transcriptional cofactors, suggesting new approaches to cancer therapy. Dr. Young’s lecture will describe recent results that further illuminate the roles of super-enhancers in control of cell identity and disease.
NLM Title: Roles for transcriptional super-enhancers in cell identity and disease / Dr. Richard Young.
Author: Young, Richard A.
National Institutes of Health (U.S),
Publisher:
Abstract: (CIT): NHGRI DIR Genome Seminar The Young laboratory studies super-enhancers (also known as stretch enhancers), which are large clusters of transcriptional enhancers that drive high-level expression of key cell identity genes. For many diseases, trait-associated sequence variation is especially enriched in the super-enhancers of disease-relevant cell types. Furthermore, the Young lab has found that cancer cells acquire super-enhancers as oncogenes and other genes important to tumor pathogenesis. In tumor cells, super-enhancer-driven oncogene expression can be exceptionally vulnerable to drugs that target transcriptional cofactors, suggesting new approaches to cancer therapy. Dr. Young's lecture will describe recent results that further illuminate the roles of super-enhancers in control of cell identity and disease.
Subjects: Enhancer Elements, Genetic
Neoplasms--genetics
Publication Types: Lecture
Webcast
 
NLM Classification: QU 470
NLM ID: 101622767
CIT Live ID: 13371
Permanent link: https://videocast.nih.gov/watch=13371

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