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\n\nMotivated behaviors fall into two valences: Seeking pleasure and avoiding pain. The ability to select appropriate behavioral responses to environmental stimuli, such as avoiding a predator or approaching a food source, is critical for survival. Although most animals are capable of learning to assign either positive or negative associations to environmental cues, Dr. Tye's lab is only at the beginning to understand the underlying neural circuits and the plasticity that mediates the formation, revision or extinction of an associative memory. Dr. Tye’s lab employs an interdisciplinary approach including optogenetics, electrophysiology, pharmacology and imaging techniques to find a mechanistic explanation for how emotional and motivational states can influence learning and behavior, in both health and disease.\n\n

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\n\nMotivated behaviors fall into two valences: Seeking pleasure and avoiding pain. The ability to select appropriate behavioral responses to environmental stimuli, such as avoiding a predator or approaching a food source, is critical for survival. Although most animals are capable of learning to assign either positive or negative associations to environmental cues, Dr. Tye's lab is only at the beginning to understand the underlying neural circuits and the plasticity that mediates the formation, revision or extinction of an associative memory. Dr. Tye’s lab employs an interdisciplinary approach including optogenetics, electrophysiology, pharmacology and imaging techniques to find a mechanistic explanation for how emotional and motivational states can influence learning and behavior, in both health and disease.\n\n

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\n\nMotivated behaviors fall into two valences: Seeking pleasure and avoiding pain. The ability to select appropriate behavioral responses to environmental stimuli, such as avoiding a predator or approaching a food source, is critical for survival. Although most animals are capable of learning to assign either positive or negative associations to environmental cues, Dr. Tye's lab is only at the beginning to understand the underlying neural circuits and the plasticity that mediates the formation, revision or extinction of an associative memory. Dr. Tye’s lab employs an interdisciplinary approach including optogenetics, electrophysiology, pharmacology and imaging techniques to find a mechanistic explanation for how emotional and motivational states can influence learning and behavior, in both health and disease.\n\n

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