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Cellular Culprits and Mechanisms Involved in ALS
Monday, November 26, 2012,
12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Brian K. Kaspar, Ph.D. is Associate Professor and Principal Investigator at The Ohio State University and The Research Institute at Nationwide Children's Hospital in Columbus, Ohio. His graduate education was at University of California San Diego specializing in molecular pathology.
After graduate study, he performed post-graduate work at The Salk Institute for Biological Studies in La Jolla, CA in the laboratory of Dr.Fred H. Gage where he pioneered various methodologies in viral gene transfer for neurological disorders. After finishing his training in 2004, he moved to The Ohio State/Nationwide Children's to start a laboratory focused on understanding and developing treatments for severe neuromuscular disorders. In 2009, Dr. Kaspar's group identified the first viral vector capable of traversing the blood brain barrier and utilized these findings to treat various neurological disorders including spinal muscular atrophy, resulting in a number of high impact publications and advancements towards human clinical trials.
Additionally, the Kaspar Laboratory has pioneered using astrocytes derived from post-mortem human familial and sporadic ALS to model the non-cell autonomous related toxicity towards motor neurons. Dr. Kaspar serves as an Editor for the
journal Molecular Therapy.