NIH VideoCast - Mitochondria: dynamic organelles critical for human health

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Mitochondria: dynamic organelles critical for human health

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Air date:	Wednesday, October 3, 2012, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 737 (135 Live, 602 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:00:09
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Mitochondria are dynamic organelles that fuse, divide, and move. Human genetic studies indicate that these processes are important for normal functioning of tissues, particularly neurons. Mutations in Mitofusion-2 (Mfn2) cause peripheral neuropathy (Charcot-Marie-Tooth 2A), and mutations in optic atrophy 1 (OPA1) cause eye disease (dominant optic atrophy). Mouse knockout studies focused on the mitofusins Mfn1 and Mfn2 have shown that mitochondrial fusion is important for organellar function. Dr. Chan will discuss mouse studies that reveal the physiological functions of mitochondrial dynamics. In addition, Dr. Chan will discuss how new mouse models can be combined with imaging approaches to understand the role of mitochondrial dynamics in neurodegeneration. The NIH Director's Wednesday Afternoon Lecture Series, colloquially known as WALS, is the highest-profile lecture program at the NIH. Lectures occur on most Wednesdays from September through June from 3:00 to 4:00 p.m. in Masur Auditorium, Building 10 on the NIH Bethesda campus. Each season includes some of the biggest names in biomedical and behavioral research. The goal of the WALS is to keep NIH researchers abreast of the latest and most important research in the Unites States and beyond. An added treat is the annual J. Edward Rall Cultural Lecture, which features top authors and other cultural icons. All speakers are nominated by the NIH community. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series

NLM Title:	Mitochondria : dynamic organelles critical for human health / David C. Chan.
Author:	Chan, David C. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Mitochondria are dynamic organelles that fuse, divide, and move. Human genetic studies indicate that these processes are important for normal functioning of tissues, particularly neurons. Mutations in Mitofusion-2 (Mfn2) cause peripheral neuropathy (Charcot-Marie-Tooth 2A), and mutations in optic atrophy 1 (OPA1) cause eye disease (dominant optic atrophy). Mouse knockout studies focused on the mitofusins Mfn1 and Mfn2 have shown that mitochondrial fusion is important for organellar function. Dr. Chan will discuss mouse studies that reveal the physiological functions of mitochondrial dynamics. In addition, Dr. Chan will discuss how new mouse models can be combined with imaging approaches to understand the role of mitochondrial dynamics in neurodegeneration. The NIH Director's Wednesday Afternoon Lecture Series, colloquially known as WALS, is the highest-profile lecture program at the NIH. Lectures occur on most Wednesdays from September through June from 3:00 to 4:00 p.m. in Masur Auditorium, Building 10 on the NIH Bethesda campus. Each season includes some of the biggest names in biomedical and behavioral research. The goal of the WALS is to keep NIH researchers abreast of the latest and most important research in the United States and beyond. An added treat is the annual J. Edward Rall Cultural Lecture, which features top authors and other cultural icons. All speakers are nominated by the NIH community. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series.
Subjects:	Mitochondrial Diseases--genetics Mitochondrial Diseases--physiopathology Mitochondrial Dynamics Neurodegenerative Diseases--genetics Neurodegenerative Diseases--physiopathology
Publication Types:	Lecture Webcast

NLM Classification:	WD 200.5.M6
NLM ID:	101595181
CIT Live ID:	11960
Permanent link:	https://videocast.nih.gov/watch=11960

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