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Autophagy Failure in Alzheimer's Disease - A Therapeutic Target?

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Air date: Monday, October 24, 2011, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 489 (36 Live, 453 On-demand)
Category: Neuroscience
Runtime: 01:09:52
Description: Neuroscience Seminar Series

Dr. Nixon’s research on Alzheimer’s disease and related neurodegenerative disorders began very early when he was a graduate student in Cell and Developmental Biology at Harvard and through periods of further training in Medicine and Psychiatry. As an independent investigator since the 1970s, his research has continuously focused on proteases and their regulation in health and disease. His research on calpains and on the lysosomal system has contributed significantly to our understanding of several fundamental and clinically important problems in aging and neurodegeneration. He has published over 250 manuscripts in peer-reviewed journals. He has successfully coordinated large teams of scientists as head of the largest research program McLean Hospital in the 1990’s; a larger Dementia Research Center at the Nathan Kline Institute in the past decade; and recently the NYU Center of Excellence on Brain Aging, a consolidated program linking all NKI and NYU dementia research which has as its principal mission facilitating the rapid translation of laboratory findings into clinically effective treatments and diagnostic modalities. These missions and objectives coincide with his long term goals to apply a novel mechanistic framework for understanding pathogenic actions of multiple genetic and environmental factors in AD to the development of effective therapeutic and prevention strategies. Dr. Nixon’s leadership responsibilities are now all consolidated within the area of AD research and treatment.

For more information, visit: http://neuroseries.info.nih.gov
NLM Title: Autophagy failure in Alzheimer's disease--a therapeutic target? / Ralph A. Nixon.
Author: Nixon, Ralph A.
National Institutes of Health (U.S.)
Publisher:
Abstract: (CIT): Neuroscience Seminar Series Dr. Nixon"s research on Alzheimer"s disease and related neurodegenerative disorders began very early when he was a graduate student in Cell and Developmental Biology at Harvard and through periods of further training in Medicine and Psychiatry. As an independent investigator since the 1970s, his research has continuously focused on proteases and their regulation in health and disease. His research on calpains and on the lysosomal system has contributed significantly to our understanding of several fundamental and clinically important problems in aging and neurodegeneration. He has published over 250 manuscripts in peer-reviewed journals. He has successfully coordinated large teams of scientists as head of the largest research program McLean Hospital in the 1990"s; a larger Dementia Research Center at the Nathan Kline Institute in the past decade; and recently the NYU Center of Excellence on Brain Aging, a consolidated program linking all NKI and NYU dementia research which has as its principal mission facilitating the rapid translation of laboratory findings into clinically effective treatments and diagnostic modalities. These missions and objectives coincide with his long term goals to apply a novel mechanistic framework for understanding pathogenic actions of multiple genetic and environmental factors in AD to the development of effective therapeutic and prevention strategies. Dr. Nixon"s leadership responsibilities are now all consolidated within the area of AD research and treatment. For more information, visit: http://neuroseries.info.nih.gov.
Subjects: Alzheimer Disease--genetics
Alzheimer Disease--physiopathology
Alzheimer Disease--therapy
Autophagy
Genetic Therapy
Publication Types: Lecture
Webcast
 
NLM Classification: WT 155
NLM ID: 101574456
CIT Live ID: 10634
Permanent link: https://videocast.nih.gov/watch=10634

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