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\nDr. Sine studies nicotinic receptors at the neuromuscular junction and in the brain. His work is focussed on understanding how agonist binding is transduced into opening of the ion channel intrinsic. In collaboration with Andy Engle he has studied the molecular mechanisms of congenital myasthenic syndromes, diseases that produce profound muscle weakness. Their work has shown that many of these syndromes result from mutations in nicotinic receptors. Analysis of changes in Ach receptor function produced by these mutations is giving profound insight into the gating mechanism, revealing novel sites of regulation that in all probability would not have been discovered were it not for the fact they were identified in myasthenic patients. \n

\nFor more information, visit the
\nNIH Neuroscience Seminar Series
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\nDr. Sine studies nicotinic receptors at the neuromuscular junction and in the brain. His work is focussed on understanding how agonist binding is transduced into opening of the ion channel intrinsic. In collaboration with Andy Engle he has studied the molecular mechanisms of congenital myasthenic syndromes, diseases that produce profound muscle weakness. Their work has shown that many of these syndromes result from mutations in nicotinic receptors. Analysis of changes in Ach receptor function produced by these mutations is giving profound insight into the gating mechanism, revealing novel sites of regulation that in all probability would not have been discovered were it not for the fact they were identified in myasthenic patients. \n

\nFor more information, visit the
\nNIH Neuroscience Seminar Series
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\nDr. Sine studies nicotinic receptors at the neuromuscular junction and in the brain. His work is focussed on understanding how agonist binding is transduced into opening of the ion channel intrinsic. In collaboration with Andy Engle he has studied the molecular mechanisms of congenital myasthenic syndromes, diseases that produce profound muscle weakness. Their work has shown that many of these syndromes result from mutations in nicotinic receptors. Analysis of changes in Ach receptor function produced by these mutations is giving profound insight into the gating mechanism, revealing novel sites of regulation that in all probability would not have been discovered were it not for the fact they were identified in myasthenic patients. \n

\nFor more information, visit the
\nNIH Neuroscience Seminar Series
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