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Genetic and epigenetic control of pluripotent stem cell differentiation to motor neurons

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Air date: Tuesday, March 29, 2011, 2:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 328 * This only includes stats from October 2011 and forward.
Category: Stem Cell
Runtime: 00:54:40
Description: NCRM/SCIG Stem Cell Seminar Series:

Hynek Wichterle is an assistant professor holding a joint appointment in the Departments of Pathology and Cell Biology, Neurology, and Neuroscience at Columbia University Medical Center in New York. He received his M.S. degree (1993) from Charles University in Prague and his Ph.D. degree (2000) from The Rockefeller University in New York. He trained as a postdoctoral fellow at Columbia University, where he became Assistant Professor in 2004.

His research focuses on developmental programs underlying specification of neuronal diversity in the developing spinal cord. His lab developed methods for directed differentiation of pluripotent stem cells into spinal motor neurons in a manner that recapitulates normal embryonic development. Using this technology he characterized molecular programs that contribute to rostro-caudal patterning of the developing spinal progenitors, providing ample supply of diverse motor neurons innervating axial, hypaxial and limb muscle targets.

Together with Dr Christopher Henderson he co-directs Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research that applies the embryonic and induced pluripotent stem cell technologies towards the study and development of new treatments for motor neuron diseases including ALS (Lou Gehrig disease) and Spinal Muscular Atrophy.

He is a member of the Center for Motor Neuron Biology and Disease and of the Stem Cell Initiative at Columbia University.
NLM Title: Genetic and epigenetic control of pluripotent stem cell differentiation to motor neurons / Hynek Wichterle.
Author: Wichterle, Hynek.
National Institutes of Health (U.S.)
Publisher:
Subjects: Cell Differentiation--physiology
Epigenesis, Genetic--physiology
Motor Neurons--cytology
Pluripotent Stem Cells--cytology
Publication Types: Lecture
Webcast
NLM Classification: QU 325
NLM ID: 101559812
CIT Live ID: 10072
Permanent link: https://videocast.nih.gov/watch=10072

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