NIH VideoCast - It's a Small World: 'Tiny Technologies' and Regenerative Medicine

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It's a Small World: 'Tiny Technologies' and Regenerative Medicine

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Air date:	Wednesday, February 23, 2011, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 176 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:02:43
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Our laboratory studies how micro- and nanoscale systems can be deployed to understand, diagnose, and treat human disease. In this talk, I will describe our progress in two application areas: liver disease and cancer. In the area of hepatic tissue engineering, we are developing microtechnology tools to understand how ensembles of cells coordinate to produce tissues with emergent properties in the body. We have used this understanding to fabricate human microliver tissues in both '2D' and '3D' formats that enable us to study the pathogenesis of human drug-drug interaction, drug-induced liver disease, and viral infection. In the area of cancer, we are developing nanotechnology tools to meet the challenge of delivering cargo into the tumor microenvironment where transport is dominated by diffusion. Our strategy is to design nanotechnologies which emulate nature's mechanisms of homing, activation, and amplification to deliver cytotoxic drugs, imaging agents, and siRNA to tumors. Thus, using nature as a guide, we are establishing a framework for building systems from micro- and nanoscale components that function collectively to treat human disease. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

NLM Title:	It's a small world : 'tiny technologies' and regenerative medicine / Sangeeta N. Bhatia.
Author:	Bhatia, Sangeeta.
Publisher:
Abstract:	(CIT): Our laboratory studies how micro- and nanoscale systems can be deployed to understand, diagnose, and treat human disease. In this talk, I will describe our progress in two application areas: liver disease and cancer. In the area of hepatic tissue engineering, we are developing microtechnology tools to understand how ensembles of cells coordinate to produce tissues with emergent properties in the body. We have used this understanding to fabricate human microliver tissues in both '2D' and '3D' formats that enable us to study the pathogenesis of human drug-drug interaction, drug-induced liver disease, and viral infection. In the area of cancer, we are developing nanotechnology tools to meet the challenge of delivering cargo into the tumor microenvironment where transport is dominated by diffusion. Our strategy is to design nanotechnologies which emulate nature's mechanisms of homing, activation, and amplification to deliver cytotoxic drugs, imaging agents, and siRNA to tumors. Thus, using nature as a guide, we are establishing a framework for building systems from micro- and nanoscale components that function collectively to treat human disease.
Subjects:	Microtechnology Nanotechnology Regenerative Medicine--methods Tissue Engineering Tumor Microenvironment
Publication Types:	Lecture Webcast

NLM Classification:	QT 36.5
NLM ID:	101557274
CIT Live ID:	10017
Permanent link:	https://videocast.nih.gov/watch=10017

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