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\nHao Wu, Ph.D., is Asa and Patricia Springer Professor of Structural Biology and Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. Lecture summary: \"Inflammasomes are supramolecular complexes that activate inflammatory caspases (1/4/5/11), which in turn cleavage a pore forming protein GSDMD to induces pyroptosis, a lytic cell death involving spillage of cellular contents, and to mediate secretion of IL-1 family cytokines. In this talk, I will focus on 1) the assembly and trafficking of inflammasomes required for their activation, and 2) assembly and selectivity of the GSDMD pore, with substantial unpublished data.\"\n

For more information go to https://oir.nih.gov/wals"}],["$","meta","2",{"name":"publisher","content":"National Institutes of Health"}],["$","meta","3",{"property":"og:title","content":"NIH VideoCast - Inflammasomes at the Crossroads of Basic Science and Therapeutic Intervention"}],["$","meta","4",{"property":"og:description","content":"NIH Director’s Wednesday Afternoon Lecture Series\n\n

\nHao Wu, Ph.D., is Asa and Patricia Springer Professor of Structural Biology and Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. Lecture summary: \"Inflammasomes are supramolecular complexes that activate inflammatory caspases (1/4/5/11), which in turn cleavage a pore forming protein GSDMD to induces pyroptosis, a lytic cell death involving spillage of cellular contents, and to mediate secretion of IL-1 family cytokines. In this talk, I will focus on 1) the assembly and trafficking of inflammasomes required for their activation, and 2) assembly and selectivity of the GSDMD pore, with substantial unpublished data.\"\n

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\nHao Wu, Ph.D., is Asa and Patricia Springer Professor of Structural Biology and Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. Lecture summary: \"Inflammasomes are supramolecular complexes that activate inflammatory caspases (1/4/5/11), which in turn cleavage a pore forming protein GSDMD to induces pyroptosis, a lytic cell death involving spillage of cellular contents, and to mediate secretion of IL-1 family cytokines. In this talk, I will focus on 1) the assembly and trafficking of inflammasomes required for their activation, and 2) assembly and selectivity of the GSDMD pore, with substantial unpublished data.\"\n

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