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\nFor the longest time a bone-centric view has dominated bone biology. This has been extremely;y fertile for our understanding of basic bone cell biology and its control by various hormones. However, if one takes into account a fundamental cell biological feature of bone and clinical observation, then it becomes obvious that the skeleton may regulate several physiological processes outside the skeleton. The lecture will review the observations that demonstrate the validity of this view broader view of bone biology. It will then address the temporal mode of action of osteocalcin and how its biology could be harnessed to treat some manifestations of aging.\n\n

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\nFor the longest time a bone-centric view has dominated bone biology. This has been extremely;y fertile for our understanding of basic bone cell biology and its control by various hormones. However, if one takes into account a fundamental cell biological feature of bone and clinical observation, then it becomes obvious that the skeleton may regulate several physiological processes outside the skeleton. The lecture will review the observations that demonstrate the validity of this view broader view of bone biology. It will then address the temporal mode of action of osteocalcin and how its biology could be harnessed to treat some manifestations of aging.\n\n

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\nFor the longest time a bone-centric view has dominated bone biology. This has been extremely;y fertile for our understanding of basic bone cell biology and its control by various hormones. However, if one takes into account a fundamental cell biological feature of bone and clinical observation, then it becomes obvious that the skeleton may regulate several physiological processes outside the skeleton. The lecture will review the observations that demonstrate the validity of this view broader view of bone biology. It will then address the temporal mode of action of osteocalcin and how its biology could be harnessed to treat some manifestations of aging.\n\n

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