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\nThe immune system employs two distinct defense strategies against infections: microbe-directed pathogen destruction typified by type 1 immunity, and host-directed pathogen containment exemplified by type 2 immunity in induction of tissue repair. Akin to infectious diseases, cancer progresses with cancer cell acquisition of microorganism-like behavior propagating at the expense of the host. While immunological mechanisms of cancer cell destruction are well defined, whether immune-mediated cancer cell containment can be induced is poorly understood. In this presentation, I will discuss how type 2 immunity can be engaged to promote tumor tissue healing, and how such a tissue-level cancer defense mechanism can be targeted for cancer immunotherapy.

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\nThe immune system employs two distinct defense strategies against infections: microbe-directed pathogen destruction typified by type 1 immunity, and host-directed pathogen containment exemplified by type 2 immunity in induction of tissue repair. Akin to infectious diseases, cancer progresses with cancer cell acquisition of microorganism-like behavior propagating at the expense of the host. While immunological mechanisms of cancer cell destruction are well defined, whether immune-mediated cancer cell containment can be induced is poorly understood. In this presentation, I will discuss how type 2 immunity can be engaged to promote tumor tissue healing, and how such a tissue-level cancer defense mechanism can be targeted for cancer immunotherapy.

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\nThe immune system employs two distinct defense strategies against infections: microbe-directed pathogen destruction typified by type 1 immunity, and host-directed pathogen containment exemplified by type 2 immunity in induction of tissue repair. Akin to infectious diseases, cancer progresses with cancer cell acquisition of microorganism-like behavior propagating at the expense of the host. While immunological mechanisms of cancer cell destruction are well defined, whether immune-mediated cancer cell containment can be induced is poorly understood. In this presentation, I will discuss how type 2 immunity can be engaged to promote tumor tissue healing, and how such a tissue-level cancer defense mechanism can be targeted for cancer immunotherapy.

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