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\nR. John Collier, Ph.D.
\nProfessor, Microbiology and Molecular Genetics
\nHarvard Medical School

\n\nDr. Collier has devoted his career to understanding the molecular mechanisms by which bacteria cause disease. His research has elucidated the structures and modes of action of bacterial protein toxins, and he has applied this knowledge to develop novel approaches to treat and prevent diseases.\n\nEarly in his career Collier discovered that diphtheria toxin (DT) inhibits protein synthesis by directly inactivating a eukaryotic polypeptide elongation factor (elongation factor-2) within the cytosol. Besides explaining the mode of action of DT, this represented the first demonstration that a bacterial protein toxin could breach a membrane protecting the mammalian cytosol from the extracellular milieu. This finding changed thinking about how protein toxins act."}],["$","meta","2",{"name":"publisher","content":"National Institutes of Health"}],["$","meta","3",{"property":"og:title","content":"NIH VideoCast - Anthrax Toxin: Structure, Activity, and New Inhibitors"}],["$","meta","4",{"property":"og:description","content":"Kinyoun Lecture

\nR. John Collier, Ph.D.
\nProfessor, Microbiology and Molecular Genetics
\nHarvard Medical School

\n\nDr. Collier has devoted his career to understanding the molecular mechanisms by which bacteria cause disease. His research has elucidated the structures and modes of action of bacterial protein toxins, and he has applied this knowledge to develop novel approaches to treat and prevent diseases.\n\nEarly in his career Collier discovered that diphtheria toxin (DT) inhibits protein synthesis by directly inactivating a eukaryotic polypeptide elongation factor (elongation factor-2) within the cytosol. Besides explaining the mode of action of DT, this represented the first demonstration that a bacterial protein toxin could breach a membrane protecting the mammalian cytosol from the extracellular milieu. This finding changed thinking about how protein toxins act."}],["$","meta","5",{"property":"og:url","content":"https://uat.d1rkikwu4q8tg.amplifyapp.com/watch/a2fb6e38-d5db-11f0-9cf9-12c45c580ad9"}],["$","meta","6",{"property":"og:site_name","content":"NIH VideoCast"}],["$","meta","7",{"property":"og:image","content":"https://nihcit.rev.vbrick.com/api/v2/media/videos/thumbnails/fe5168b6-685a-4684-9e68-f23b7eea427b.jpg"}],["$","meta","8",{"property":"og:type","content":"website"}],["$","meta","9",{"name":"twitter:card","content":"summary_large_image"}],["$","meta","10",{"name":"twitter:title","content":"NIH VideoCast - Anthrax Toxin: Structure, Activity, and New Inhibitors"}],["$","meta","11",{"name":"twitter:description","content":"Kinyoun Lecture

\nR. John Collier, Ph.D.
\nProfessor, Microbiology and Molecular Genetics
\nHarvard Medical School

\n\nDr. Collier has devoted his career to understanding the molecular mechanisms by which bacteria cause disease. His research has elucidated the structures and modes of action of bacterial protein toxins, and he has applied this knowledge to develop novel approaches to treat and prevent diseases.\n\nEarly in his career Collier discovered that diphtheria toxin (DT) inhibits protein synthesis by directly inactivating a eukaryotic polypeptide elongation factor (elongation factor-2) within the cytosol. Besides explaining the mode of action of DT, this represented the first demonstration that a bacterial protein toxin could breach a membrane protecting the mammalian cytosol from the extracellular milieu. This finding changed thinking about how protein toxins act."}],"$L22","$L23","$L24"],"error":null,"digest":"$undefined"}