The NIH Roadmap National Centers for Biomedical Computing (NCBC) Lecture Series Presents: “Dissecting Human Lymphoid Malignancies Using a Systems Biology Approach”

About the lecture:

Comprehensive repertoires of molecular interactions (interactomes) are increasingly useful in the dissection of biological processes. However, their role in the elucidation of novel, validated mechanisms of regulation of physiologic and pathologic human phenotypes is still largely untested. Additionally, while multi-cellular regulation is exquisitely cell-context dependent, most interactomes lack context specificity because their interactions are supported by ex vivo assays or context-free literature data. Finally, available mammalian interactomes only represent individual interaction layers, such as transcriptional regulation or signal transduction, rather than a more realistic, integrated view of regulatory processes across multiple layers.

A multi-layer Human B-cell interactome (HBCI), representing approximately 66,000 B-cell-specific transcriptional, signaling, and protein-complex interactions, has been assembled using an evidence integration approach. The HBCI constitutes a unique resource for a humancell context and integrates evidence supporting specific molecular interactions from multiple computational and experimental sources. This talk will address the application of the HBCI to the elucidation of master regulators of both physiologic and tumor-related phenotypes in mature human B cells.

About the program and speakers:

Drs. Dalla-Favera and Califano will be presenting as part of the Powered by NCBC Lecture Series. This series highlights outcomes from the NIH Roadmap National Centers for Biomedical Computing (NCBC) Driving Biological Projects (DBP), which are intended to drive interactions between computational and biomedical scientists.

Dr. Califano is Principal Investigator of the National Center for the Multiscale Analysis of Genomic and Cellular Networks (MAGNet) and Professor of Biomedical Informatics at Columbia, with appointments in the Department of Biomedical Informatics and in the Institute for Cancer Genetics. He received his Ph.D. in physics from the University of Florence. His scientific interests are broadly defined within the field of systems biology, with specific application to human malignancies.

Dr. Dalla-Favera, leader of one of MAGNet’s several DBPs, is Professor of Pathology and Genetics and Development at the College of Physicians and Surgeons of Columbia University, Director of the Institute for Cancer Genetics, and Director of the Herbert Irving Comprehensive Cancer Center at Columbia University. Dr. Dalla-Favera has been recognized with several national awards, including the Stohlman Award from the Leukemia Society of America, two NIH MERIT Awards, the Outstanding Achievement Award from the American-Italian Cancer Foundation, and the William Dameshek Prize for Outstanding Contribution to Hematology from the American Society of Hematology. He has made major contributions to the understanding of the pathogenesis of cancer, particularly lymphoma.

For more information, visit http://www.ncbcs.org/