1c:{"metadata":[["$","title","0",{"children":"NIH VideoCast - The Molecular Basis of Memory Loss in Transgenic Models of Alzheimer's Disease"}],["$","meta","1",{"name":"description","content":"Dr. Ashe's research addresses the molecular basis of memory loss and cognitive dysfunction in Alzheimer's disease. The studies involve the creation of transgenic mouse models of Alzheimer's disease in order to understand how the amyloid-ß and tau proteins impair memory and cognition. The work has shown that the aggregates of amyloid-ß and tau proteins which define Alzheimer's disease neuropathologically do not cause cognitive deficits in mice. These investigations have led to the discovery of a form of the amyloid-ß protein called Aß star (Aß*) that disrupts cognitive function in mice and rats, and revealed a potential mechanism by which interactions with a neuronal receptor may impair memory.\n
\n
\nNIH Neuroscience Seminar Series\n
"}],["$","meta","2",{"name":"publisher","content":"National Institutes of Health"}],["$","meta","3",{"property":"og:title","content":"NIH VideoCast - The Molecular Basis of Memory Loss in Transgenic Models of Alzheimer's Disease"}],["$","meta","4",{"property":"og:description","content":"Dr. Ashe's research addresses the molecular basis of memory loss and cognitive dysfunction in Alzheimer's disease. The studies involve the creation of transgenic mouse models of Alzheimer's disease in order to understand how the amyloid-ß and tau proteins impair memory and cognition. The work has shown that the aggregates of amyloid-ß and tau proteins which define Alzheimer's disease neuropathologically do not cause cognitive deficits in mice. These investigations have led to the discovery of a form of the amyloid-ß protein called Aß star (Aß*) that disrupts cognitive function in mice and rats, and revealed a potential mechanism by which interactions with a neuronal receptor may impair memory.\n
\n
\nNIH Neuroscience Seminar Series\n
"}],["$","meta","5",{"property":"og:url","content":"https://uat.d1rkikwu4q8tg.amplifyapp.com/watch/9bffdfeb-d5db-11f0-9cf9-12c45c580ad9"}],["$","meta","6",{"property":"og:site_name","content":"NIH VideoCast"}],["$","meta","7",{"property":"og:image","content":"https://nihcit.rev.vbrick.com/api/v2/media/videos/thumbnails/3e14e08b-6360-481e-a7b2-02c272c8eb20.jpg"}],["$","meta","8",{"property":"og:type","content":"website"}],["$","meta","9",{"name":"twitter:card","content":"summary_large_image"}],["$","meta","10",{"name":"twitter:title","content":"NIH VideoCast - The Molecular Basis of Memory Loss in Transgenic Models of Alzheimer's Disease"}],["$","meta","11",{"name":"twitter:description","content":"Dr. Ashe's research addresses the molecular basis of memory loss and cognitive dysfunction in Alzheimer's disease. The studies involve the creation of transgenic mouse models of Alzheimer's disease in order to understand how the amyloid-ß and tau proteins impair memory and cognition. The work has shown that the aggregates of amyloid-ß and tau proteins which define Alzheimer's disease neuropathologically do not cause cognitive deficits in mice. These investigations have led to the discovery of a form of the amyloid-ß protein called Aß star (Aß*) that disrupts cognitive function in mice and rats, and revealed a potential mechanism by which interactions with a neuronal receptor may impair memory.\n
\n
\nNIH Neuroscience Seminar Series\n
"}],"$L22","$L23","$L24"],"error":null,"digest":"$undefined"}