1c:{"metadata":[["$","title","0",{"children":"NIH VideoCast - Sensing Infection: Toll-Like Receptors and the Genetic Analysis of Mammalian Innate Immunity"}],["$","meta","1",{"name":"description","content":"Mammals have an inherent capacity to recognize and respond to specific molecules of microbial origin, on a time scale of minutes following inoculation. A detailed understanding of precisely how recognition and response are mediated has stood as one of the principal goals of immunology. \nAmong the molecules recognized, lipopolysaccharide (LPS; endotoxin) has been most widely used to model infection, yet its receptor remained unknown until recently. We identified the receptor for LPS by positionally cloning a locus in mice (Lps) that governed LPS responses. The Lps locus was shown to encode Toll-like receptor 4, a homolog of the Drosophila Toll protein, which had been shown to have both developmental and immunological functions. \n
\n
\nFor more information, visit
\nhttp://www.scripps.edu/research/faculty.php?tsri_id=8340\n
\n
\nWALS\n
"}],["$","meta","2",{"name":"publisher","content":"National Institutes of Health"}],["$","meta","3",{"property":"og:title","content":"NIH VideoCast - Sensing Infection: Toll-Like Receptors and the Genetic Analysis of Mammalian Innate Immunity"}],["$","meta","4",{"property":"og:description","content":"Mammals have an inherent capacity to recognize and respond to specific molecules of microbial origin, on a time scale of minutes following inoculation. A detailed understanding of precisely how recognition and response are mediated has stood as one of the principal goals of immunology. \nAmong the molecules recognized, lipopolysaccharide (LPS; endotoxin) has been most widely used to model infection, yet its receptor remained unknown until recently. We identified the receptor for LPS by positionally cloning a locus in mice (Lps) that governed LPS responses. The Lps locus was shown to encode Toll-like receptor 4, a homolog of the Drosophila Toll protein, which had been shown to have both developmental and immunological functions. \n
\n
\nFor more information, visit
\nhttp://www.scripps.edu/research/faculty.php?tsri_id=8340\n
\n
\nWALS\n
"}],["$","meta","5",{"property":"og:url","content":"https://uat.d1rkikwu4q8tg.amplifyapp.com/watch/9af3ba4e-d5db-11f0-9cf9-12c45c580ad9"}],["$","meta","6",{"property":"og:site_name","content":"NIH VideoCast"}],["$","meta","7",{"property":"og:image","content":"https://nihcit.rev.vbrick.com/api/v2/media/videos/thumbnails/dbbe7a85-563b-4377-b8f5-f108be68c57d.jpg"}],["$","meta","8",{"property":"og:type","content":"website"}],["$","meta","9",{"name":"twitter:card","content":"summary_large_image"}],["$","meta","10",{"name":"twitter:title","content":"NIH VideoCast - Sensing Infection: Toll-Like Receptors and the Genetic Analysis of Mammalian Innate Immunity"}],["$","meta","11",{"name":"twitter:description","content":"Mammals have an inherent capacity to recognize and respond to specific molecules of microbial origin, on a time scale of minutes following inoculation. A detailed understanding of precisely how recognition and response are mediated has stood as one of the principal goals of immunology. \nAmong the molecules recognized, lipopolysaccharide (LPS; endotoxin) has been most widely used to model infection, yet its receptor remained unknown until recently. We identified the receptor for LPS by positionally cloning a locus in mice (Lps) that governed LPS responses. The Lps locus was shown to encode Toll-like receptor 4, a homolog of the Drosophila Toll protein, which had been shown to have both developmental and immunological functions. \n
\n
\nFor more information, visit
\nhttp://www.scripps.edu/research/faculty.php?tsri_id=8340\n
\n
\nWALS\n
"}],"$L22","$L23","$L24"],"error":null,"digest":"$undefined"}