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\nThe mammalian olfactory system relies on a specialized signal transduction system and highly organized neuronal wiring to detect odorants with high sensitivity and specificity. Targeted manipulation of genetic components in this system have revealed important roles of the odorant receptor,the cyclic nucleotide-gated ion channel and tissue-specific transcription factors for neuronal development, axonal targeting, stimulus detection, and desensitization. Dr. Reed has been a pioneer in characterizing the molecular bases of olfaction. His current research addresses how the genes that encode odorant receptors are organized and how their expression is regulated. He uses mouse models engineered with altered expression of olfactory receptors to study the patterns of activity and neuronal connections in the brain\n

\nMore information by
\nRandy Reed
"}],["$","meta","2",{"name":"publisher","content":"National Institutes of Health"}],["$","meta","3",{"property":"og:title","content":"NIH VideoCast - Engineering Altered Sensory Systems: Regulation of Gene Expression and Function in Mammalian Olfaction"}],["$","meta","4",{"property":"og:description","content":"NIH Neuroscience Seminar\n

\nThe mammalian olfactory system relies on a specialized signal transduction system and highly organized neuronal wiring to detect odorants with high sensitivity and specificity. Targeted manipulation of genetic components in this system have revealed important roles of the odorant receptor,the cyclic nucleotide-gated ion channel and tissue-specific transcription factors for neuronal development, axonal targeting, stimulus detection, and desensitization. Dr. Reed has been a pioneer in characterizing the molecular bases of olfaction. His current research addresses how the genes that encode odorant receptors are organized and how their expression is regulated. He uses mouse models engineered with altered expression of olfactory receptors to study the patterns of activity and neuronal connections in the brain\n

\nMore information by
\nRandy Reed
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\nThe mammalian olfactory system relies on a specialized signal transduction system and highly organized neuronal wiring to detect odorants with high sensitivity and specificity. Targeted manipulation of genetic components in this system have revealed important roles of the odorant receptor,the cyclic nucleotide-gated ion channel and tissue-specific transcription factors for neuronal development, axonal targeting, stimulus detection, and desensitization. Dr. Reed has been a pioneer in characterizing the molecular bases of olfaction. His current research addresses how the genes that encode odorant receptors are organized and how their expression is regulated. He uses mouse models engineered with altered expression of olfactory receptors to study the patterns of activity and neuronal connections in the brain\n

\nMore information by
\nRandy Reed
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