>> WELCOME TO THE ANNUAL
BIRCWH MEETING FOR 2022.
MY NAME IS LISA BEGG AND I'M THE
PROGRAM OFFICIAL FOR THE BIRCWH
PROGRAM.
IT'S MY HONOR AND PLEASURE TO
OPEN THE MEETING TODAY.
AS YOU CAN SEE, WE ARE VIRTUAL
THIS YEAR.
YOU MAY JOINING VIA THE NIH
VIDEO CAST OR THROUGH OUR
VIRTUAL PLATFORM.
AS YOU CAN SEE HERE, FOR THOSE
OF YOU THAT ARE ALREADY
REGISTERED, I'D LIKE TO BRING
YOUR ATTENTION TO THE NAVIGATION
GUIDE HIGHLIGHTED IN THE CENTER.
FOR THOSE OF YOU THAT WOULD LIKE
TO JOIN, THERE ARE ADVANTAGES TO
THAT.
CAN YOU STILL REGISTER BY GOING
TO BIRCWH2022. VFAIRS.COM AND IT
IS ALSO ON THE ORWH WEBSITE.
IF YOU REGISTERED, YOU WILL BE
PART OF THE VIRTUAL PLATFORM FOR
THE ENTIRE DAY.
YOU CAN POSE QUESTIONS THROUGH
THE Q&A TAB AND COMMUNICATE WITH
OTHER ATTEND'S VIA THE CHATBOX
AND ALSO PARTICIPATE IN THE
AFTERNOON'S POSTER SESSION WITH
OUR BIRCWH SCHOLARS WHICH WE
INVITE TO YOU DO THAT.
IT'S 51 POSTERS THAT HAVE BEEN
ACCEPTED.
THE VIRTUAL PLATFORM WILL RUN IN
THE 4:00 P.M. TODAY.
OUR FIRST SPEAKER WILL BE OUR
DIRECTOR Dr. JANINE AUSTIN
CLAYTON, WHO WILL GIVE OPENING
REMARKS AND INTRODUCE THE RUTH
L. KIRSCHSTEIN AWARD FOR 2022.
Dr. CLAYTON CELEBRATED HER
TENTH ANNIVERSARY AS OUR
DIRECTOR AND SHE'S A PHYSICIAN
SCIENTIST WHO WAS CONDUCTED
RESEARCH IN HER OWN RIGHT OVER
THE YEARS AT NIH AND SHE HAS
SPEARHEADED A MAJOR POLICY
CHANGE FOR NIH WITH SEX AS A
BIOLOGICAL POLICY IMPLEMENTED
AND ADVANCING THE STUDY OF SEX
AND GENDER DIFFERENCES.
PLEASE WELCOME Dr. CLAYTON.
>> THANK YOU SO MUCH, Dr. BEGG
FOR THAT KIND INTRODUCTION.
SO, IT'S SO EXCITING TO WELCOME
YOU HERE TO OUR ANNUAL BIRCWH
MEETINGS.
THINGS HAVE BEEN CHANGING IN THE
WORLD, AS ALL OF US KNOW.
I WANT TO SET STAGE, AS I AGAIN,
TALKING ABOUT HOW WOMEN ARE
FARING IN THE LABOR FORCE.
WE'VE TALKED ABOUT WOMEN IN THE
LABOR FORCE IN SCIENCE AND LABOR
FORCE GENERALLY HAVE EXPERIENCED
CAREER SET BACKS AND IT'S BEEN
HARD.
AFTER ALL THE WORK ALL OF US
HAVE DONE, MANY OF YOU HERE,
LEADERS, SCHOLARS AND NIH AND
BEYOND TO ADVANCE WOMEN'S
CAREERS IN SCIENCE IT'S BEEN
PAINFUL TO SEE SOME OF THE DATA
AND STATISTICS AND HEAR IT
CALLED NOT A RECESSION BUT A
SHE-SESSION.
FORTUNATELY, THE GOOD NEWS IS,
DATA FROM THE BUREAU OF LABOR
STATISTICS ARE STARTING TO SHOW
THAT WOMEN ARE COMING BACK
STRONG AND IN FACT, WOMEN'S
EMPLOYMENT GAINS HAVE OUT PLACED
MEN FOR THE PAST SIX OF THE LAST
EIGHT MONTHS AND WE'RE ALSO
SEEING IMPROVEMENTS ACROSS THE
BOARD.
EVEN THOUGH WE'RE HERE TODAY, TO
CELEBRATE THE SUCCESS OF WOMEN
AND RESEARCH, WE WANT TO JUST
KEEP IN MIND THE LARGER CONTEXT
AND I WANTED TO FRAME THOSE
REMARKS AT THE BEGINNING HERE TO
ENCOURAGE US ALL TO UP LIFT ALL
WOMEN, CONTINUE TO HELP THOSE IN
YOUR LABS AND IN YOUR CLINICS,
ESPECIALLY THOSE ON THE FRONT
LINES AND THOSE AT THE EARLY
STAGES OF THEIR CAREERS, WHO
HAVE BEEN MOST AFFECTED BY THE
PAST TWO AND A HALF YEARS.
SOME OF THE CHANGES IN THE PAST
TWO AND A HALF YEARS MAY BE
BRINGING TO THE FLOOR THE WAY
THAT WE EVALUATE SCIENTIST AND
APPLICANTS.
I WAS REALLY INTERESTED TO SEE
THIS PIECE IN "NATURE" WHERE A
GROUP IS PROPOSING A CHANGE TO
HOW SCIENTISTS AND APPLICANTS
ARE EVALUATED BOTH FOR GRANTS
AND FOR HIRING AND THEY'RE
PROPOSING A SYSTEM THAT WOULD
DEEMPHASIS IMPACT FACTORS AND
AGE AND THE INSTITUTIONS FROM
WHICH A SCIENTIST OR CANDIDATE
COMES BECAUSE OF THESE FACTORS
AND HOW THEY CONTRIBUTE TO BUY
AS.
MAYBE ONE OF THE CHALLENGES TO
THE WORKFORCE THAT COMES FROM
THE CHANGES WILL RESULT IN A
MORE HOLISTIC ASSESSMENT OF
CANDIDATES.
LATER TODAY, YOU ARE HEAR FROM
Dr. JUDITH JAMES AS OUR LEGACY
OF LEADERSHIP LECTURER AND I
WANT TO OFFER HER MY HEARTFELT
CONGRATULATIONS IN HER RECENT
ELECTION INTO THE NATIONAL
ACADEMY OF MEDICINE.
Dr. JAMES IS A FIFTH
GENERATION OKLAHOMAN A PIONEER
IN THE FIELD OF SYSTEMIC
AUTOIMMUNELY AND ADVANCED HOW
AUTO MANY UNION DISEASES START
AND HOW IMMUNE RESPONSES EVOLVE.
FROM HAVING TREATED PATIENTS
WITH SYSTEMIC LUPUS AND DISEASES
LIKE SHOW GRIN SYNDROME, THESE
DISEASES ARE PARTICULARLY
CHALLENGING AND HAVE, IN THE
PAST, BEEN TRULY
LIFE-THREATENING.
Dr. JAMES' LEADERSHIP AND
DEDICATION TO THE FIELD OF
AUTOIMMUNITY HAS CHANGED LIVES
AREN'T THE WORLD AND THAT IS
WHAT THE PRESIDENT OF OMRF SAID,
HE SAID SHE'S DEVOTED HER LIFE
AND THE DIFFICULT TO TREAT
DISEASES IT RECOGNIZES THE
IMPACT SHE'S HAD BOTH IN THE LAB
AND FOR PATIENTS.
SHE IS ALSO BEEN DEVOTED TO
IMPROVING THE HEALTH OF NATIVE
AMERICANS.
CONGRATULATIONS AND WE LOOK
FORWARD TO YOUR PRESENTATION
LATER TODAY.
THE TITLE OF HER PRESENTATION IS
"THE WINDING ROAD OF RESEARCH
AND LESSON ALONG THE WAY."
SO I'M ALSO REALLY EXCITE TODAY
SHARE WITH YOU SOME OF THE DATA
FROM THIS YEAR'S BIRCWH SCHOLARS
AND WE HAVE 82 CURRENT SCHOLARS
FROM 19 ACTIVE PROGRAMS AND WE
HAVE 51 POSTERS WE'RE
HIGHLIGHTING ACROSS DISCIPLINES
AND SCIENTIFIC TOPICS AND WE HAVE
UNDER REPRESENTED IN MEDICINE
SCHOLARS IN EVERY PROGRAM SO
WE'RE THRILLED TO SEE THE REACH
AND BREADTH OF THIS YEAR'S
BIRCWH SCHOLARS AND I AM DOUBLY
EXCITED TO SHARE THE DIVERSITY
IN THE BIRCWH PROGRAM.
NINE OF OUR PROGRAMS ARE
COLLABORATING WITH HBC YOU OR
MINORITY-SERVING INSTITUTIONS,
OVER 10 OF THEM, AND WE'RE
DELIGHTED TO SEE THIS REACH AND
BREADTH AND DIVERSITY THAT
EXPAND THEXEXPANDS THE STRENGTH OF THE
BIRCWH PROGRAM.
RECENTLY, A NICE PUBLICATION,
LED BY ESTHER CHEW, WITH Dr.
HEART MAN, OUR LECTURER AS A
CO-AUTHOR, TALKED ABOUT WHAT
CONTRIBUTES TO BUY SCHOLAR
SUCCESS.
WE KNOW THESE FACULTY TRAINING
AWARDS ARE ADVANCING EARLY
CAREER FACULTY AND RESEARCH AND
HAVE BEEN INSTRUMENTAL IN
EXPANDING THE WOMEN'S HEALTH
RESEARCH CAD RAY ACROSS COUNTRY.
AND THIS PUBLICATION FOCUSED ON
THE BIRCWH ASK IT HIGHLIGHTED
THESE FACTORS THAT WERE CRITICAL
AND IN THE MENTOR, PERSISTENCE,
RESILIENCE.
THE CAPACITY TO DEVELOP
COMMUNITY AND TO HAVE NETWORKS.
AND THE PROGRAM DIRECTOR'S
TALKED ABOUT HOW IMPORTANT IT
WAS TO HAVE STRONG, ACTIVELY
ENGAGE MENTORS WHO BOTH SUPPORT
THE SCHOLARS' CAREER AND
CULTIVATE THE SCHOLARS RESEARCH
FOCUS.
THEY TALKED ABOUT THE IMPORTANCE
OF DEVELOPING A PERSONAL
RESEARCH VISION SO THE SCHOLAR
CAN ENSURE ALIGNMENT WITH THE
ACTIVITIES WITH A
WELL-ESTABLISHED VISION AND
HIGHLIGHTED THAT SOME GROUPS ARE
MORE VULNERABLE THAN OTHERS IN
THE RESEARCH WORKFORCE INCLUDING
CLINICIANS, WOMEN AND PARENTS
AND UNDER REPRESENTED GROUPS.
CLINICIAN SCHOLARS AND PARENTS
WERE ALSO THE MOST VULNERABLE
FORAFOR ATTRITION FROM A RESEARCH
CAREER AND THERE'S COMPETITION
FOR THE LIMITED TIME THAT ALL OF
US HAVE AVAILABLE BETWEEN FAMILY
OR CLINICAL DUTIES AND RESEARCH.
THEY HIGHLIGHTED THE IMPORTANCE
OF, IN THE CONTEXT OF ATTRITION,
MENTORS AND P.I.s FRAMED THE
OBSERVE IN TERMS OF A INDIVIDUAL
RESPONSIBILITY OR INSTITUTIONAL
RESPONSIBILITY AND THOSE THAT
HIGHLIGHTED THE RESPONSIBILITY
OF THE INSTITUTION AND IN
SUPPORTING THE MENTOR WERE ABLE
TO FRAME SUCH ATTRITION IN A
POSITIVE AND CONSTRUCTIVE WAY.
PROMOTING SCHOLAR SUCCESS
INCLUDING THE CRITICALITY OF A
PLAN FOR TRANSITIONING TO OTHER
FUNDING, THE IMPORTANCE OF
DEVELOPING A TIMELINE FOR
PUBLICATIONS AND GRANTS
SUBMISSIONS, AND AS WELL AS
DEVELOPING A BACK-UP PLAN OR
PLAN B IF APPLICATIONS ARE
UNSUCCESSFUL.
AND HOW CRITICAL IT IS TO ENSURE
AND ENCOURAGE SCHOLARS TO
SOLIDIFY THEIR CLINICAL DUTIES
AND TEACHING ROLES EARLY.
HAVING THE SCHOLARS WORK WITH
PROGRAM FACULTY TO SOLIDIFY A
MULTI-STAGE TRANSITION PLAN WAS
ALSO CITED AS IMPORTANT.
AND OF COURSE, MENTORING IS AT
THE HEART OF THE BIRCWH PROGRAM.
THAT INCLUDES ALL OF THE MET FOR
METAFOR I CAN SITUATIONS YOU CAN
HAVE.
WE TALK ABOUT HOW CRITICAL IT IS
FOR WOMEN IN SCIENCE AND THE
DEVELOPMENT OF WOMEN'S HEALTH
RESEARCHERS.
THIS THINGS CAN'T BE IMPARTED
THROUGH A PRE-RECORDED ZOOM
CLASS.
THE IMPORTANCE OF HAVING SOMEONE
THERE TO STAND WITH YOU, TO
STAND FOR YOU, AND TO HELP YOU
AND TO SUPPORT AS YOU GO THROUGH
CHALLENGES.
WE ALL NEED SOMEONE WHO HAS BEEN
THERE AND I DO WANT TO HIGHLIGHT
Dr. VIVIAN PEN WHO HAS BEEN
THE INSPIRATION AND MOTIVATING
FORCE HYPED THE BIRCWH PROGRAM
AND IT'S BEEN A TIRELESS MENTOR
TO SO MANY OF US AND CONTINUES
TO WANT TO INSPIRE OTHERS TO
MENTOR.
THE ANNUAL BIRCWH KEYNOTE HONORS
Dr. RUG L. KIRSCHSTEIN.
SHE WAS THE LEADING SCENERY
SEARCHER FOR POLIO, MEASLES AND
RUBELLA SO IT WAS AT THE
FOREFRONT OF HER MIND MANY, MANY
YEARS AGO.
SHE WAS THE FIRST INSTITUTE
DIRECTOR FROM 1974 FOR ALMOST 20
YEARS TO 1993.
SHE SERVED AS THE ACTING NIH
DIRECTOR TWICE.
AND SHE HELPED TO CHANGE THE
DEMOGRAPHICS OF THE NIH.
RECOGNIZING TALENT, AND
ENCOURAGING THE HIRING AND PRE
MOTION OF FEMALE AND UNDER
REPRESENTED MINORITY RESEARCHERS
INTO LEADERSHIP ROLES.
Dr. KIRSCHSTEIN HAD MANY
IMPACTS ACROSS NIH AND THIS IS
JUST ONE WAY THAT WE HONOR HER
AND WE ENSURE HER IMPACTS ARE
REMEMBERED.
THIS YEAR'S RUTH L. KIRSCHSTEIN
MEMORIAL LECTURE WILL BE
DELIVERED BY Dr. KATHERINE
HARTMANN.
SHE'S AN EPIDEMIOLOGIST WITH
EXPERIENCE IN LARGE COHORTS,
BEHAVIORAL INTERVENTIONS,
CLINICAL TRIALS, ASSESSMENT OF
MEDICAL TESTS AND TEACHING
QUANTITIVE METHODS.
MUCH OF HER PRIMARY RESEARCH
FOCUSES ON GETTING ANSWERS THAT
MATTER.
AND ADVERSE PREGNANCY OUTCOMES,
PELVIC FLOOR DISORDERS AND
THYROID DISEASE.
SHE ALSO SERVES IN CROSS-CUTTING
ROLES IN POLICY-RELEVANT AREAS
INCLUDING HEALTH SERVICE, HEALTH
OUTCOMES, EVIDENCE-BASED
PRACTICES, SYSTEMATIC REVIEWS,
COST AN A LOAL SIS AND COMPARATIVE HE
CAN TIVENESS AND YOU CAN SEE
FROM HER TITLES HERE AS VICE
PRESIDENT FOR RESEARCH
INTEGRATION, ASSOCIATE DEAN FOR
CLINICAL AND TRANSLATIONAL
SCIENTIST DEVELOPMENT,
PROFESSOR, OF OBSTETRICS AND
GYNECOLOGY AND MEDICINE, AND THE
LUCIUSE.BURCH CHAIR OF
REPRODUCTIVE PHYSIOLOGY AND
FAMILY PLANNING.
SHOWS A TRAILBLAZER AND HAS
MULTIPLE ROLES TO PLAY AND
MULTIPLE HATS SHE WEARS ON ANY
GIVEN DAY.
SHE HAS A POPULAR ADVICE COLUMN,
YOU COULD CALL IT, ON THE
WEBSITE EDGE FOR SCHOLARS.
SHE DISCUSSES TOPICS YOU WANT TO
LEARN FROM A MENTOR.
YOU CAN CATCH A GLIMPSE OF HER
GREAT SENSE OF HUMOR THERE.
IN DEED, SHE'S THE PERFECT
CHOICE TO PRESENT THIS YEAR'S
KIRSCHSTEIN MEMORIAL LECTURE.
AS A FORMER BIRCH SCHOLAR AND
P.I. WITH MANY OF HER MULTI
P.I.s ON HER GRANT, BEING ALSO
FORMER BIRCWH SCHOLARS, SHE HAS
ALL OF THE CRITICAL
CHARACTERISTICS THAT WE PUSH
FORWARD IN THE BIRCWH PROGRAM.
IT'S MY PRIVILEGE TO Dr.
KATHERINE HARTMANN THE RUTH L.
KIRSCHSTEIN.
NO ONE TELLS YOU HOW TO DEAL
WITH CATEGORY 6 RAPIDS IN LIFE.
Dr. HARTMANN.
>> THANK YOU, I'M EXCITED TO BE
WITH YOU TODAY.
AS YOU'VE HEARD, THIS CELEBRATES
A REMARKABLE WOMAN, I FEEL I
KNOW HER A BIT THROUGH HER
FRIENDS WHO I KNOW.
Dr. KIRSCHSTEIN WAS A PERSON
WHO NAVIGATED SCIENTIFIC
ACHIEVEMENT, REMARKABLE
LEADERSHIP AND DEDICATION TO HER
FAMILY WITH RARE SKILL.
ON A PERSONAL LEVEL, SHE'S
DESCRIBED AS A HEAD OF A TIME,
KEEPING HER MAIDEN NAME AT A
TIME WHEN THAT WASN'T DONE,
MARRIED TO ANOTHER NIH POWER
HOUSE, AND KNOWN FOR BRINGING
HER CHILD TO WORK WITH HER AND
TO CONFERENCES AND GIFTED AT
ENJOYING LIFE AND INCLUDING DATE
AND FAMILY NIGHTS SO I'M HONORED
TO BE WITH YOU TO PRESENT.
BIRCWH IS PART OF MY LIFE FOR
MORE THAN 20 YEARS AND I WAS IN
THE FIRST COHORT OF SCHOLARS AND
MANY SCHOLARS WHO WEPT ON TO
LEAD BIRCWH PROGRAMS.
BIRCWH WERE MY MENTORS AND WERE
MY COLLEAGUES AND LIFE-LONG
SOUNDING BOARDS.
OTHER SCHOLARS ALSO BECAME
EXCEPTIONALLY VALUED PEERS,
COLLEAGUES AND COLLABORATORS IN
MY GRANT WORK.
DESPITE OUR VIRTUAL FORMAT
TODAY, I HOPE YOU WILL TAKE THE
TIME TO MEET EACH OTHER,
VIRTUALLY THROUGH E-MAIL OR
OTHER MECHANISMS TO START
CONVERSATIONS ABOUT SHARED
INTEREST AND I LOOK FORWARD TO A
YEAR WHEN WE'RE ALL BACK
TOGETHER.
I HAVE LED THE BIRCWH PROGRAM AT
VANDERBILT FOR 15 YEARS AND I'M
EXCITED, AS OF THIS ROUND OF
FUNDING WE'RE A MULTI-P.I. AWARD
WITH TWO EXCEPTIONAL ALUMNI AS
OUR PROGRAM DIRECTORS AND CO
P.I.s.
THOSE ARE Dr. AMY MAJOR AND
Dr. DIGNA EDWARDS AND WE MAY
BE THE ONLY SITE IN THE COUNTRY
THAT IS LED BY FORMER BIRCWH
SCHOLARS.
SO, WHY HAVE WE INVESTED SO MUCH
IN BIRCWH?
BIRCWH OPENED THE DOORS FOR US
AND FOR A RESEARCH CAREER.
THIS IS THE WEBSITE FOR THE
RIGHT FROM THE START STUDY.
MY TIME IN BIRCWH LAID THE
GROUNDWORK THAT SPANNED NINE
COMMUNITIES AND THREE STATES.
FEEDBACK, CRITIQUE AND PRACTICAL
WISDOM FROM EXPERIENCED
RESEARCHERS RESULTED IN A STUDY
STRUCTURE AND METHODS THAT HAVE
BECOME A MODEL FOR LARGE-SCALE
MULTI-STATE STUDY OF PREGNANCY
OUTCOMES INCLUDING EVENTS LIKE
MISCARRIAGE AND PRE TERM BIRTH.
LAST YEAR, I HAD THE OPPORTUNITY
TO SPEAK AT AN NIH STATE OF THE
SCIENCE CONFERENCE AS A KEYNOTE
ABOUT HOW WE ACCOMPLISHED
IMPOSSIBLE THINGS LIKE
RECRUITING PARTICIPANTS BEFORE
PREGNANCY, AND UNIVERSAL USE OF
RESEARCH ULTRASOUNDS THAT WERE
NOT REPORTED BACK TO
INDIVIDUALS' MEDICAL RECORDS
THAT WERE DEEMED INFEASIBLE WHEN
WE FIRST STARTED TRYING TO PLAN
THE PERFECT STUDY.
DURING BIRCWH, OUR RESEARCH TEAM
SURVIVED THE INITIAL STUDY
SECTION REVIEWS ASSERT ASKING
THE APPROACH WASN'T FEASIBLE AND
BY RESUBMITTING DATA WITH 900
WOMEN AND THREE DIFFERENT STATES
AND WENT ON TO BE MORE THAN MORE
THAN 9,000 WOMEN IN CONTACT WITH
THE STUDY.
I WOULD LIKE TO TALK ABOUT YOUR
CAREER.
ACROSS MY EDUCATION AND
TRAINING, I LOOKED AT MENTORS
AND OTHERS WHO I ADMIRED AND
ANTICIPATED STARTING A NEW,
EASIER AND MORE PREDICTABLE
PHASE OF LIFE THAT WAS GOING TO
LOOK SOMETHING LIKE THIS.
DO ANY OF YOUR DAILY LIVES LOOK
LIKE THIS?
SMOOTH AND CALM WHERE STUDY
PROGRESS AND BRIGHT SUNSHINE
GREET YOU EVERY MORNING.
IT WAS A REALLY NICE FANTASY.
IN REALITY, IT'S MORE LIKE THIS
ON A GOOD DAY.
WE ALL KNOW THAT TURBULENCE IS
ROUTINE AND AS SCHOLARS YOU ARE
BLESSED TO HAVE MENTORS WHO HELP
YOU PREPARE AND RESPOND TO
NORMAL, ACADEMIC TURBULENCE LIKE
GRANT AND MANUSCRIPT CRITIQUES
AND FAILED EXPERIMENT AND
ACADEMIC DISAPPOINTMENTS.
ALL OF THESE ARE LEGITIMATE
CHALLENGE THAT'S REQUIRE
GUIDANCE TO DEMYSTIFY THEM AND
TO NAVIGATE WELL IN YOUR
FORTUNATE TO BE IN YOUR BIRCWH
PROGRAMS.
HOWEVER, THERE ARE FAR MORE
DISRUPTIVE CATEGORY 6 RAPID, AND
THINGS THAT CAN HAPPEN IN LIFE
AND THIS STRETCH OF RIVER HEADS
STRAIGHT FOR AN IMPRESSIVE
WATERFALL.
THESE REPRESENT THE CHALLENGE
THAT'S WE DON'T DISCUSS.
THAT'S THE WHITE WATER THAT
HAPPENS IN OUR LIVES OUTSIDE OFF
WORK.
IN ACADEMIC PUBLICATIONS, WE MAY
DOCUMENT THE RAPIDS, PRESENT IN
OUR LIVES ENCLOUD CAREGIVING,
DEMANDS, FAMILY AND PERSONAL
HEALTH CRISIS AND OTHER LIFE
CHANGING EVENTS AND WE PUBLISH
ABOUT NOT ADDRESSING THESE BUT
WE RARELY OFFER GUIDANCE FOR
WAYS THAT INDIVIDUALS CAN
DEVELOP SKILLS AND RESOURCES TO
NAVIGATE CHALLENGE FORT BENEFIT
OF THOSE WE LOVE AND FOR OUR
CAREERS.
AS PART OF THE GROUNDWORK FOR
PROGRAM TO PROVIDE PRACTICAL
SUPPORTS TO FACULTY, WE SOUGHT
TO MAP THE RAPIDS AND DETERMINE
THE PREVALENCE OF SPECIFIC LIFE
CHALLENGES AND THE INCIDENTS OF
STRESSFUL LIFE EVENTS.
WE SURVEYED HUNDREDS OF EARLY
CAREER FACULTY ASKING THEM,
ABOUT THE PRIOR YEAR IN THEIR
LIVES.
EARL CAREER FOR THE PURPOSES OF
THIS SURVEY, WHICH WAS
ELECTRONIC, WAS TO INDIVIDUAL ON
INDIVIDUALS ON K OR COMPARABLE
AWARDS OR THOSE IN THE FIRST TWO
YEARS OF THEIR FIRST RO1.
SO THESE WERE THE PEOPLE WHO
RESPONDED.
THE AVERAGE AGE WAS COMPARABLE
TO THE NATIONAL AVERAGE FOR
EARLY CAREER SCHOLARS AT NEARLY
40 AND HALF WERE WOMEN, 63% WERE
ASSISTANT PROFESSOR WITH THE
MAJORITY OF THE OTHERS BEING AT
LOWER RANK LIKE INSTRUCTORS, AND
A FEW BEING AT ASSOCIATE
PROFESSOR AND THOSE BEING THE
PEOPLE WHO WERE THIS FIRST RO1.
70% HAD AN MD WITH OR WITHOUT
OTHER GRADUATE DEGREES AND 30%
WERE PH.D SCIENTISTS.
MEN AND WOMEN WERE EQUALLY
LIKELY TO BE MARRIED AND THEY
ALSO WERE EQUALLY LIKELY TO HAVE
CHILDREN.
WHERE ARE THE CHALLENGES THAT
THEY EXPERIENCED.
16% HAVE HAD A CHILD HAD SURGERY
IN THE PRIOR YEAR AND 22% HAVE
HAD AN ADULT MEMBER OF THEIR
HOUSEHOLD WHO HAD BEEN
HOSPITALIZED AND 28% SEPARATE
FROM THOSE QUERIES ABOUT SURGERY
HAD A CHILD HOSPITALIZED DURING
THE PRIOR YEAR.
WHEN WE ASKED ABOUT CARE
COORDINATION, WHICH WE
CONSIDERED TO BE PRIMARY
RESPONSIBILITY FOR OVERSEEING
THE SCHEDULING IMPLEMENTATION
AND FOLLOW THROUGH OF CARE FOR
HEALTH-RELATED CONDITIONS 4%
REPORTED HAVING A CHILD WHO HAD
A CHRONIC DEBILITATING CONDITION
WHO NEEDED CONTINUOUS
THERAPEUTIC INTERVENTION AND 21%
WERE RESPONSIBLE FOR CARE
COORDINATION FOR AN ADULT
OUTSIDE OF THEIR HOME AND 5% FOR
ELDER CARE THAT OFTEN INCLUDED
RESIDENTIAL LIVING AND 1% WERE
IN THE MIDST OF HELPING WITH
HOSPICE CARE.
WE CONSIDERED THE STRESSFUL LIFE
ABOUT SCALE OF STRESS OR IN OUR
LIVES AND YOU WILL SEE THAT 64%
OF THE FACT YOU WILL TEE
REPORTED AT LEAST ONE STRESSFUL
LIFE SPENT AND AN AVERAGE CLOSER
TO TWO.
THIS INCLUDED 18% REPORTING
MAJOR MONEY PROBLEMS, 9% HAVING
A PARTNER WITH SERIOUS ILLNESS,
AND 8% TOTAL SUFFERING SOME FORM
OF ABUSE, 4% HAD AN EXPERIENCE
OF DISASTER OR VIOLENCE AND 3%
HAD DIVORCED IN THE PRIOR YEAR.
WHEN WE ASKED FOR MORE DETAILS
ABOUT WHAT HAPPENED, THESE WERE
THE SORTS OF THINGS THAT PEOPLE
REPORTED.
AND I KNOW THAT YOU ARE FAMILIAR
WITH THESE SORTS OF THINGS
HAPPENING IN YOUR OWN FAMILY,
AND AMONG YOUR PEERS.
I WANT YOU TO CONSIDER WHAT
PREPORTION OF THE FACULTY WHO
HAS SUCH EVENTS, HAD REPORTED
THIS OR SOUGHT TO PROBLEM-SOLVE
WITH THEIR DIVISION CHIEFS,
CHAIRS, OR MENTORS.
NOT A SINGLE ONE HAD.
WHY DO WE GO IT ALONE AND HIDE
THE THINGS THAT WE'RE FACING.
IN FOCUS GROUPS, THREE KEY
THINGS EMERGED.
THE FIRST WAS ABOUT COMMUNITY
AND THERE WAS AN INDIVIDUAL
ETHIC THAT WAS FAIRLY UNIFORM OF
STRIVING AND SUCCEEDING AND A
SENSE OF FAIRNESS AND THEY
RECOGNIZED THAT IF THEY HAD A
NEED FOR A CHANGE IN THE CALL
SCHEDULE, HELPING THEIR LAB OR
OTHER FORMS OF SUPPORT, IT MIGHT
MAKE THINGS WORSE OR WOULD
DEFINITELY MAKE THINGS WORSE FOR
SOMEONE ELSE.
SECOND WAS A SENSE THAT THINGS
COULD GET WORSE AND THEY DIDN'T
WANT TO CALL IN FAVORS TOO SOON
IN CASE THEY DID GET WORSE AND
THE THIRD WHICH WAS A ESPECIALLY
STRONG AND FEAR OF THE
IMPRESSIONS OF OTHERS AND MOST
OF ALL, THEY DID NOT WANT OTHERS
TO FEEL PITY FOR THEM OR STRESS
THAT.
THEY REPORTED EXPERIENCES OF
SEEING OTHERS JUDGED FOR THE
CIRCUMSTANCES THEY WERE IN AND
OR FOR HOW THEY WERE HELPING
THEM AND LAST THEY WORRIED ABOUT
ROLES THEY COULD DO WELL BECAUSE
JANE OR JOHN WAS IN THE MIDDLE
OF CRISIS AND SO, FIRST LESSON
IN HERE IS WHEN THINGS HAPPEN
IT'S LIKELY THAT THINGS WILL
HAPPEN AND WHEN YOU ARE READ TO
GO DO THAT AND TO SAY A FEW MORE
TIMES THAT EVERY RIVER HAS
RAPIDS AND YOU DID NOT PUT THEM
THERE.
AND THESE ARE THINGS THAT ARE
HELPFUL REGARDLESS OF WHETHER OR
NOT IT GETS BUMPY AND THE FIRST
ONE MAY BE SO AND THEN THERE MAY
BE INTRODUCTIONS TO PEOPLE WHO
LEASE CARS OR HAVE OTHER
RESOURCE AND BEFORE YOU KNOW IT,
YOU HAVE A WHOLE NEW LIFE AND
BECAUSE OF DELAYED GRATIFICATION
OF SO MANY YEARS OF TRAINING,
BEFORE YOU LINE FAR YOU WILL TEE
OR GET MORE SETTLED INTO A
PERMANENT POSITION, IT'S EASY TO
TAKE ON A DIFFERENT LIFESTYLE
OVERNIGHT AND OFTEN THAT
LIFESTYLE IS COMPLETELY WITHIN
YOUR NEW MEANS AND THAT GETS TO
POINT TO, IT REALLY CRUCIAL IN
ORDER TO HAVE THE FLEXIBILITY TO
ADDRESS CHALLENGES AND IN WAYS
THAT MAKE IT EASIER TO GET OUT
OF DEBT AND STAY OUT OF DEBT AND
THE BEST WAY TO PROCEED WITH
THAT IS TO START AN EMERGENCY
FUND WHILE YOU ARE ALSO DOING
THAT AND MAKE SURE THAT YOU ARE
HONEST WITH YOURSELVES ABOUT
WHAT IT TAKES TO HAVE THREE TO
SIX MONTHS OF YOUR REAL EXPENSES
INSURANCE PAYMENTS, GAS, FOOD,
MORTGAGE, RENT, WHATEVER IT IS
THAT MAKES UP YOUR MONTHLY
BUDGET AND KNOW THAT AND BE
HONEST WITH YOURSELVES ABOUT
HAVING A SUBSTANTIAL JUNE ON AND
WE WOULD ACTUALLY COVER A COUPLE
OF MONTHS.
SAFETY LIKE HELMETS AND
FLOTATION DEVICES ARE NOT
EXCITING BUT THIS ISN'T THE TIME
OF YEAR WHEN WE ALL GET TO THINK
ABOUT THAT TYPICALLY OPEN
ENROLLMENT IN OCTOBER AND FOR
US, AND WE'RE FORTUNATE THAT WE
WORK AT THE KIND OF PLACE THAT'S
OFFER SOLID HEALTH INSURANCE BUT
YOU CAN BILL THAT WELL.
ONE IS TO SET A RATIONAL
DEDUCTIBLDEDUCTIBLE LEVEL.
MAKE IT LOWER.
IF YOU FOCUS ON THE PRIOR ISSUES
OF GETTING AND STAYING OUT OF
DEBT AND HAVING AN EMERGENCY
FUND, MAKE SURE -- IF YOU HAVE
THE OPTION OF PURCHASING
ADVANCED MENTAL HEALTH COVERAGE,
DO IT.
THERE MAY BE MANY, MANY YEARS
WHEN YOU DON'T NEED IT AND
SHOULD YOU OR A MEMBER OF YOUR
FAMILY NEED THAT COVERAGE, IT'S
ABSOLUTELY WRENCHING TO HAVE A
MINIMAL NUMBER OF SESSIONS
COVERED AND THEN HAVE TO FIGURE
OUT HOW TO COVER WEEKLY OR TWICE
MONTHLY OR MONTHLY ENGAGEMENTS
IN MENTAL HEALTH OVER THE
LONG-TERM WITHOUT INSURANCE
COVERAGE WHICH GETS TO WHY YOU
WANT HEALTH SAVINGS ACCOUNT THE
VERSIONS THAT ROLL OVER FROM
YEAR TO YEAR AND YOU WANT BOTH
LIFE INSURANCE AND DISABILITY
INSURANCE AND IF YOU ARE YOUR
INSTITUTION DOESN'T OFFER YOU
BOTH, IT'S CRUCIAL TO MAKE SURE
THAT YOU HAVE DISABILITY
INSURANCE THAT WOULD REPLACE
YOUR INCOME AND SINCE IT'S MORE
LIKELY FOR HEALTH PROFESSIONALS
AND OTHERS IN ACADEMIC MEDICAL
CENTER SETTINGS TO EXPERIENCE
DISABILITY THAN IT IS TO NEED
THE LIFE INSURANCE BENEFIT
ALTHOUGH BOTH IDEALLY YOU WOULD
HAVE BUT MANY OF OUR
INSTITUTIONS PROVIDE ONE AND NOT
THE OTHER.
LASTLY, EARLY, WHEN YOU TOTALLY
NOT NEED IT OR WHEN YOU WANT TO
UNDERSTAND IT FOR A FRIEND OR
WHEN YOU THINKING ABOUT FUTURE
OF EVENTS LIKE PLANNING A
PREGNANCY, MAKE SURE YOU
UNDERSTAND WHAT YOUR EMPLOYEE
ASSISTANCE OR FACULTY ASSISTANCE
PROGRAM THAT IS THE FAP ACRONYM
IS ABLE TO PROVIDE OR DIRECT YOU
TO.
WHAT RESOURCES THEY HAVE AND.
THEY'RE LIKELY TO BE MUCH MORE
ROBUST THAN YOU EXPECT AND
INCLUDE HOME HEALTH NURSING,
SICK CHILDCARE AND WAYS TO
ASSIST WITH THE CARE OF OLDER
PARENTS OUT OF STATE AND NOT
LOCAL.
SO IT'S A GREAT IDEA TO
UNDERSTAND WHAT IS AT YOUR
FACULTY ASSISTANCE PROGRAM AND
ALSO, TO GET FAMILIAR WITH THE
FAMILY MEDICAL LEAVE ACT.
MANY PEOPLE FEEL LIKE THAT'S THE
ULTIMATE LAST STEP AND UNAWARE
THERE ARE LEAVE FOR THINGS THAT
OCCUR ON A PARTICULAR SCHEDULE.
SO IF YOU GET FAMILIAR WITH
THAT, YOU WILL BE MORE INFORMED
FOR YOURSELVES AND FOR OTHERS
WHO YOU ARE SUPPORTING AROUND
YOU.
MAYBE THE MOST IMPORTANT ADVICE
IN ALL OF THIS IS TO MAKE SURE
THAT YOU HAVE FELLOW TRAVELERS.
ABOUT 80% OF PEOPLE WHO ARE
FULL-TIME RESEARCHERS ARE
INTROVERTS.
WE'RE NOT NECESSARILY GOOD AT
BEING IN COMMUNITY AND YOU
ACTUALLY NEED TO WORK AT IT AND
IT WILL PAYOFF IN MANY, MANY
WAYS.
WHETHER IT'S DEEPER ENGAGEMENT
IN YOUR FAITH COMMUNITY, IN
VOLUNTEER EFFORTS, OR EVEN WITH
YOUR FRIENDS AND PEERS IN YOUR
ACADEMIC COMMUNITY AND YOUR
DIVISION AND YOUR DEPARTMENTS
AND SOCIAL AND RELAXED WAYS SO
THAT YOU REALLY KNOW EACH OTHER
AND THE ABILITY TO DISCLOSE IF
YOU NEED TO AND TO HELP EACH
OTHER IS STRONG.
KNOW YOUR NEIGHBORS.
I LIVED IN BOTH CITIES UNTIL WE
STARTED MOVING TO ACADEMIC
UNIVERSITY SETTINGS IN CHAPEL
HILL NORTH CAROLINA.
THERE WAS A DIFFERENT SKILL SET.
TO MEET AND GREAT PEOPLE AS THEY
MOVED IN, TO HOST POTLUCK
PARTIES AND KNOW EACH OTHER'S
CHILDREN AND IN THE COURSE OF
THAT, BE PROACTIVE ABOUT
BRINGING UP, HOW CAN I HELP YOU
IF SOMETHING COMES UP?
DO YOU NEED AN ADDITIONAL
EMERGENCY CONTACT.
WOULD YOU FEEL COMFORTABLE
HELPING ME IF SOMETHING HAPPENS?
BECAUSE HAVING THAT CONTACT
INFORMATION, AND HAVING
FAMILIARITY WITH EACH OTHER AND
YOUR WORK LIVES CAN BE
TREMENDOUSLY HELPFUL.
LIKEWISE, HAVE UP FRONT
DISCUSSIONS ABOUT CRISIS
MANAGEMENT WITH YOUR FAMILY
MEMBERS AND I HAVE TWO SIBLINGS
AND SINCE COLLEGE, WE'VE NEVER
LIVED IN THE SAME STATE AND ONLY
ONE OF MY SIBLINGS NEAR MY
PARENTS.
THAT REALLY CREATED EXTREME
DIFFICULTIES ABOUT ASSUMPTIONS
OF HOW WE WOULD MANAGE THINGS
AND WHO WOULD BE THERE AND HOW
WE WOULD ASSIST AND HOW LONG WE
COULD BE AVAILABLE AND IN THE
MIDDLE OF OUR FIRST CRISIS IN A
SYSTEM THAT SAVED US MANY TIMES
SINCE THAT INDICATES I NEED TO
YOU COME HERE NOW, OR I NEED TO
TALK TO YOU MORE OFTEN.
I NEED SUPPORT IN THIS.
TALKING ABOUT THE TYPES OF
THINGS THAT ARE INEVITABLE AS
FAMILY AGES OR WITH MEMBER
OVERSEAS OR OTHER CHALLENGES,
IT'S NOT ANYTHING ON FIRE IS
TREE MACHINE DOESLY HELPFUL AND
LASTLY HAVE ADAPTABLE SUPPORT IN
YOUR LIFE.
THAT FOR US HAS INCLUDED ULSRUD
BEING INVOLVED WITH
UNDERGRADUATE STUDENTS WHO
NEEDED JOBS TO HAVE INCOME WHERE
WE CAN PROVIDE FLEXIBLE THINGS
THAT THEY CAN HELP WITH AND THAT
WE NEEDED AS A FAMILY AND AGAIN,
GET TO KNOW THEM OVER TIME THEY
COULD HELP WITH FIXING A MEAL OR
RUNNING YOU CAN SEE THE WHITE
WATER LOOMING IS THE TIME TO ASK
YOUR MENTORS AND OTHERS FOR
INTRODUCTIONS.
ASK FOR CONFIDENTIALITY IF YOU
NEED IT.
I NEED TO MEET PEOPLE WHO HAVE
BEEN THROUGH THIS.
ASK THEM TO SHARE THEIR
EXPERIENCES.
ASK THEM TO REFLECT ON WHAT THEY
DID RIGHT AND WHAT THEY WISH
THEY HAD DONE DIFFERENTLY AND AT
THIS POINT, VISIT OR CALL AND
HAVE A CONSULTATION WITH YOUR
EMPLOYEE OR FACULTY ASSISTANCE
PROGRAMS.
THEY OFTEN ARE OFFER SHORT TERM
COACHING OR COUNSELING SESSIONS
TO HELP WITH THE NAVIGATION AND
THEN WHEN YOU ARE COMFORTABLE,
CONTACT ORGANIZATIONS ON YOUR
CAMPUS, AND INCLUDING FOR
INSTANCE, MANY UNIVERSITIES NOW
HAVE THE DORIS DUKE FUND TO
RETAIN CLINICIAN SCIENTISTS AND
THEY HAVE FABULOUS RESOURCES TO
ALSO GET SUPER PRACTICAL ABOUT
HOW TO MAKE IT THROUGH
PARTICULAR TYPES OF CHALLENGES.
AND LASTLY I'D LIKE TO SAY THAT
I THINK SENIOR FACULTY AND
MENTORS HAVE A RESPONSIBILITY TO
SHARE OUR STORIES AND WHAT WE'VE
LEARNED.
SO IF WE FOCUS ON FOR JUST A
MINUTE, NOT ON EARLY CAREER
FACULTY BUT ON MORE SENIOR
PEOPLE, I WOULD LIKE TO TAKE A
DETOUR TO SOME THOUGHTS FOR YOU
AND THAT IT IS REALLY IMPORTANT
THAT WE SHARE THE MAP.
NORMATIVE DATA CAN CHANGE
CULTURE.
WHEN WE STARTED THE SURVEY, THE
DATA I PRESENTED, I THOUGHT IT
WOULD BE 9% OR 10% AND I HAVE NO
SENSE THAT A QUARTER OF PEOPLE
WOULD HAVE HOUSEHOLD MEMBERS
HOSPITALIZED, SURGERIES, BE
RESPONSIBLE FOR HOSPICE CARE AND
EVEN LESS SENSE THAT LIFE EVENT
SCALE WOULD ADD ANOTHER 20% OF
THAT MEANING THAT PROBABLY 50%
OF EARLY CAREER FACULTY ARE
HAVING SOME SIGNIFICANT
STRESSORS TO BALANCE WITH THEIR
WORK LIFE DURING A NORMAL YEAR.
THAT'S NOT HOW WE CONSIDERED AND
IT'S NOT HOW WE ORGANIZED
RESOURCES.
WE HAVE TO PROVIDE THE RIGHT
GEAR.
WE HAVE TO PROMOTE THROUGH THE
ROLES WE'RE IN AS MENTORS AND
CAREER DEVELOPMENT PROGRAMS AND
USE OF FACULTY INTRODUCING NEW
PROGRAMS AND WE NEED TO DO IT IN
PRACTICAL WAYS INCLUDING
INFORMATION AND IN FACULTY ON
BOARDING AND ORIENTATION AND
HAVING INDIVIDUALS COME AND
SPEAK AT SEMINAR SERIES AS PART
OF NORMATIVE CHANGES TO OUR
OCCUR ACTUAL AND WE HAVE TO
COACH THE PROCESS AND NONE OF US
HAVE BEEN IN ACADEMICS GOT
THROUGH THIS WITH NO PRESSURES
AND A SMOOTH SAILING CANOE ON A
LAKE AND WE REAL VE TO TALK
ABOUT HOW IT WENT AND WHAT WE
WISH WE HAD DONE DIFFERENTLY AND
WE NEED TO THINK ABOUT IF THERE
ARE PRACTICAL WAYS THAT WE CAN
INVEST IN THE JOURNEY WE'VE
LEARNED THROUGH OUR PARTNERSHIP
IN RETAINING EARLY CAREER
FUNDING BY THE DORIS DUKE
FOUNDATION AND THE FINANCIAL
RESOURCES WE NEED TO PROVIDE ARE
VERY, VERY MODEST AND THEY'RE
FOR A PORTION OF THE YEAR OR
HAVING THEM STEP OUT OF ACADEMIC
LIFE AND SMALLMENTS OF FUNDS OR
SUPPORT WITH PARTICULAR
PERSONNEL INJECTED INTO THE WORK
LIFE, BY HELPING IN THE LAB AND
EVEN TO PROVIDE THINGS AND
PULLING ALL MY COMMENTS
TOGETHER, IT WILL REALLY BE
POSSIBLE TO TAKE ON EVEN VERY
DIFFICULT WHITE WATER.
IT WILL GIVE YOU CONFIDENCE AND
I SWEAR I'VE LEARNED THIS
PERSONALLY, IT WILL GIVE YOU
CONFIDENCE YOU WILL GET THROUGH
THIS AND MAYBE HAVING IT IN
PLACE IN ADVANCE OR HAVING MANY
OF THESE THINGS IN PLACE IN
ADVANCE AND IT'S A TREMENDOUS
SAFETY NET.
SO, BY WAY OF REASSURANCE THAT
EARLIER THE MORE DETAILED WHAT
HAPPENED WAS NOT OVER SHARING
CONFIDENTIAL DETAILS.
PEOPLE THAT I MEET.
THESE ARE SOME OF THE THINGS
THAT HAPPENED DURING MY CAREER.
WHEN I STARTED MY FIRST JOB,
MULTIPLE STATES AWAY I WAS THE
ONLY MEDICAL PERSON IN MY
FAMILY.
MY FATHER HAD A HEART ATTACK,
HAD BY PASS SURGERY AND STARTED
HAVING NEW TIAs, THAT TH THAT'S NOT
NEW.
MOST OF US HAVE INDIVIDUALS IN
OUR FAMILY WHO HAVE
CARDIOVASCULAR CHARGES AND HE
NEEDED MEDICAL INTERVENTION.
ESPECIALLY IF YOU HAVE A MEDICAL
BACKGROUND, YOU ARE LIKELY TO BE
THE INDIVIDUAL IN YOUR FAMILY
WHO IS LEANED ON TO BE THERE AND
HELP INTERPRET.
THEN WHEN I STARTED MY NEXT JOB,
WITHIN A FEW MONTHS, MY CHILD
LOST ALL NORMAL FUNCTION IN
ORDER TO GET THE BEST POSSIBLE
CARE, WE MOVED HER TO A HOSPITAL
THAT HAD REHABILITATION FOR HER
PARTICULAR DEFICITS WHERE SHE
WAS HOSPITALIZED FOR MORE THAN
SIX MONTHS.
MY HUSBAND AND I OFTEN PASSED IN
THE AIRPORT AS EACH OF US TOOK
HALF OF A WEEK IN HOUSTON IN
ORDER TO BE WITH HER.
SEEING YOUR CHILD DEVASTATED, IT
IS INCOMPARABLE AND IT IS THE
THING, BECAUSE WE WERE IN A NEW
JOB, WHERE WE OWNED TWO HOUSES
IN TWO CITIES AND WE HAD BEEN IN
A STATE JOB WITHOUT RAISES FOR
QUITE SOME TIME, IT GOT US
TALKING WITH BANKRUPTCY LAWYERS.
BECAUSE WE WERE LIVING RIGHT AT
THE EDGE OF OUR MEANS AND WE
THOUGHT NEVER HAD THE
OPPORTUNITY TO BUILD AN
EMERGENCY FUND.
ALL MY KIDS ARE ADULTS NOW.
THIS CHILD IS A 32-YEAR-OLD WITH
A FABULOUS CAREER WHO RECOVERED
ALL FUNCTION COGNITIVE FUNCTION
AND DID INCREDIBLY WELL BUT IT
WAS A REALLY ROUGH GOING.
WE COORDINATED MY FATHER IN
LAW'S HOSPICE CARE IN A
DIFFERENT STATE FOR 18 MONTHS
AND TOOMONTHS.A NUMBER OF YEARS I WAS WITH MY
BEST FRIEND'S HUSBAND WHEN HE
WAS MURDERED IN HIS GYM AND
DEVELOPED PRETTY FLOOR I HAD
PTSD FROM THE TYPE OF VIOLENT
TACK AND IT TOOK ALMOST TWO
YEARS TO QUIT HAVING FLASH BACKS
OF THAT EVENT ON A REGULAR
BASIS.
AND DUNG THE MIDST OF ALL OF
THAT, MY PARENTS WITH RAPIDLY
PROCESSING DEMENTIA WERE
REFUSING RESIDENTIAL CARE AND
DECIDED IT WOULD BE GOOD TO TAKE
THEIR CHILDREN TO COURT TO BE
ALLOWED TO STAY AT HOME, EVEN
AFTER THERE WAS A KITCHEN FIRE
AND MY FATHER GOING MISSING FOR
ALMOST 20 HOURS.
SO, THINGS HAPPEN, I PRAY THEY
DON'T HAPPEN TO YOU, BUT YOU
HAVE TO SHARE THESE STORIES AND
I'M NOT SUPER HUMAN.
MY FAMILY AND I LEARNED EVERY
SINGLE ONE OF THE LESSONS I
SUGGESTED TO YOU TODAY.
WE FLAILED, WE CONSIDERED
BANKRUPTCY, WE CRIED, GRIEVED
AND WE CLUNG ONTO THE THINGS
THAT MATTERED MOST.
WITH OUR SIBLINGS, EXTENDED
FAMILIES AND FRIENDS AND
NEIGHBORS, BUT AGAINST THIS
BACKDROP, LIFE WEPT ON.
I HAVE A 36-YEAR MARRIAGE, FOUR
AMAZING ADULT CHILDREN AND MY
CAREER SURVIVED.
OUR PAPERS HAVE BEEN CITED MORE
THAN 10,000 TIMES AND I'VE
ENJOYED MENTORING MORE THAN 100
SCIENTISTS INCLUDING GRADUATE
STUDENTS, POSTDOCS, FACULTY,
UNDER GRADS, THE GAM THE AND I
HAVE RECEIVED AT LEAST AROUND
$40 MILLION IN GRANTS AND
CONTRACTS SERVED IN NATIONAL
ROLES THAT I SOUGHT OUT AND
THRIVED IN LEADERSHIP ROLES THAT
I WAS ASKED TO TAKE ON.
I LEARNED TO BE HOME FOR DINNER
TO STRETCH MY INTROVERTED SELF
INTO REAL RELATIONSHIPS THAT I
BELIEVED PREVIOUSLY I DIDN'T
HAVE THE TIME FOR.
SO, IT TOOK ME MANY YEARS TO BE
PREPARED FOR THE WHITE WATER
BECAUSE MY GENERATION TREATED
SUCH CHALLENGES AS PERSONAL
ISSUES THAT ARE TOO (INAUDIBLE)
TO DISCUSS THAT'S WHY I'M
TRUSTING YOU TODAY, TO HEAR
PIECES OF MY ACTUAL STORY.
SO THINGS HAPPEN TO MOST OF US
IN A TYPICAL YEAR.
I PROMISE YOU, YOU WILL BE
REWARDED IF YOU PLAN BY THINKING
AHEAD AND DON'T PUT YOUR HEAD IN
THE SAND.
THINK THROUGH WHAT YOU MIGHT
NEED.
GET FAMILIAR WITH RESOURCES.
KEEP YOUR FINANCES IN ORDER.
BUILD A ROBUST EMERGENCY FUND.
HAVE A PLAN FOR HELP AND TALK
WITH PEOPLE AROUND YOU AND ABOUT
HOW YOU CAN BE HELPING EACH
OTHER NOW.
EVEN IN DAILY LIFE.
AND IF YOU NEED TO, ACCEPT HELP
WHEN IT'S NEEDED YOU WILL MEET
THESE CHALLENGES AND TAKE PRIDE
HOW YOU HANDLE CHALLENGES IF YOU
TAKE ON THAT PREPARATION.
I HOPE IN FUTURE YEARS WHEN
WE'RE BACK IN-PERSON THAT SOME
OF YOU WILL FIND ME AND TELL ME
THAT NOTHING HAS HAPPENED BUT
YOU ARE IN GREAT SHAPE.
OR WHAT DID HAPPEN AND HOW
THINGS WENT FOR YOU AND WHAT YOU
LEARNED.
YOU KNOW YOU ARE HEARTY AND
TOUCH YOU ARTOUGH.TAKE A SECOND TO THINK A BOUT
WHAT IT REQUIRED OF YOU.
SO I WANT TO ASK ONE MORE TIME,
A WORD OF ENCOURAGEMENT, FOR YOU
TO HONOR THE FACT THAT EVERY
RIVER HAS RAPIDS, YOU DID NOT
PUT THEM THERE, LIFE WILL
HAPPEN.
BOTH CHALLENGING THINGS AND
REALLY GREAT THINGS AND EMBRACE
THE CHALLENGE.
>> Dr. HARTMANN.
WE HAVE A QUESTION HERE FROM
YOUR TALK AND FROM WORKING WITH
YOU, YOU'VE BEEN PART OF THE
OVER ALL BIRCWH PROGRAM FROM ITS
EARLIEST DAYS AS A SCHOLAR AND
THEN AS A LONG-TERM P.I.
OVER THESE 20 PLUS YEARS,
SCIENCE ASK CAREER DEVELOPMENT
HAVE CHANGED GREATLY.
DO YOU HAVE ANY SUMMARY GENERAL
ADVICE YOU CAN GIVE THE
SCHOLARS, THE MENTORS, THE NIH
STAFF ON THIS VIRTUAL MEETING AS
WELL AND WE WOULD APPRECIATE A
LONGER TERM PERSPECTIVE SINCE
YOU'VE BEEN PART OF THIS
IMPORTANT PROGRAM.
THANK YOU.
>> THANK YOU.
I THINK MY ADVICE FOR PEOPLE ADD
STRAIGHTING CARES IS INCLUDED IN
THE TALK.
IT'S TO NOT JUST BE AWARE THAT
THERE ARE CAREGIVING CHALLENGES
OR OTHER ISSUES THAT SHOULD BE
ADDRESSED TO PREVENT FACULTY
BURNOUT OR PROGRAMS TO PROMOTE
RESILIENCE, AND IT'S RATHER TO
GET PRACTICAL ABOUT WHAT THINGS
WE CAN PROVIDE AND WHAT THINGS
WE CAN TEACH SKILLS OR ENCOURAGE
AND TO BE MORE FLEXIBLE PERHAPS
WITH CAREER DEVELOPMENT PROGRAM
BUDGETS.
SO, OUT OF A GENERAL FUND, I
PROVIDE FUNDS FOR COACHING.
WHEN LIFE IS REALLY TOUGH, WE
SUPPORT ADDITIONAL SESSIONS
THROUGH CONFIDENTIAL COUNSELING
SERVICES AND WE OFTEN DO INVEST
INTO SHORT TERM USE OF EXTRA
EFFORT FROM A LAB MANAGER AND
WHILE SOMEONE HAS THEIR PARTNER
IN THE HOSPITAL FOR CANCER CARE.
OR SHORT TERM USE OF AN EDITOR
FOR A GRANT THAT CAN GO IN ON
TIME WHILE SOMEONE THEMSELVES IS
ILL SO I THINK THAT THINKING
FLEXIBLY ABOUT WHAT OUR BADGE ET
CATEGORIES FOR HOW WE CAN ASSIST
IN THE WORKPLACE, AND BEING UP
FRONT AND SOMETHING SOME IDEAS
ABOUT THE THINGS WE CAN SUGGEST
THAT INDIVIDUALS COULD REQUEST
AND THAT WE CAN GROW TO SO, I
WOULD HOPE THAT EVERY ONE OF OUR
BIRCWH SCHOLARS FOR INSTANCE
WOULD SAY I NEED TO STEP BACK
AND I LOVE THE WEEKLY WORK IN
PROGRESS SESSION AND I KNOW IT
ONLY WORKS WHEN WE ALL
CONTRIBUTE AND I WOULD LIKE TO
PRESENT MY REPLY TO THE
REVIEWERS AND NEXT WEEK AND TAKE
A MONTH GAP WHILE THIS IS GOING
ON AND I KNOW IN A HEARTBEAT, WE
WOULD SAY YES.
I KNOW BECAUSE OF THE FOCUS
GROUPS AND SURVEYS AND
NETWORKING WITH DOZENS AND
DOZENS OF FACULTY IN THE MIDST
OF CRISIS, THAT THEY OFTEN DON'T
WANT TO WANT A FAVOR AND THEY
OFTEN BELIEVE THEY HAVE TO
REFEEL THAN THEY HAVE TO AND IN
ORDER TOO GET SOME FLEXIBILITY
AND IF WE CAN WE CAN MAKE IT
SAFER TO ACKNOWLEDGE THAT LIFE
HAPPENS.
>> THANK YOU.
>> SO, THANK YOU VERY MUCH FOR
THAT VERY INSPIRING TALK THAW
GAVE US AND MY NAME IS ANNIE AND
I'M FROM CAREERS AT THE ORWH AND
FOR ME THE SURVEY THAT YOU
PRESENTED WAS VERY REVEALING AND
YOU HAVE IDENTIFIED CHALLENGES
THAT SCHOLARS AND ESIs FACE
THAT YOU YOURSELF HAVE
EXPERIENCED AND DESPITE THEM
IT'S NOW A VERY ACCOMPLISHED
SCIENTIST AND CAN YOU DISCUSS IF
THESE CHALLENGES THAT YOU
MENTIONED BASED ON YOUR
EXPERIENCE IN THE BIRCWH PROGRAM
HAVE INCREASED OR BECOME AGO VA
RATE ISED DURING THE RECENT
COVID PANDEMIC?
>> ABSOLUTELY.
ACTUALLY I THINK WE HAVE A PAPER
THAT IS COMING OUT OF THE DOORS
OF THE PROGRAM SITE THAT TALKS
ABOUT HOW COVID EXACERBATED THIS
AND WORE ALL COMPLETELY AWARE
TOO THAT WE'RE LEFT IN THIS RIFT
WHERE SOME OF THE PERSONAL
INTERACTION AND SUPPORTIVE
THINGS HAPPENING OVER
CONVERSATIONS BEFORE OR AFTER
SEMINARS OR LUNCH MEETINGS, AND
VANISHED AND WE'RE HAVING
TROUBLE COMING BACK AND ONE OF
MY CHALLENGES OR REQUESTS FROM
OUR GROUPS HAS BEEN, LET'S
FIGURE OUT HOW TO RECONNECT AND
LET'S FIGURE OUT HOW, AGAIN, IF
YOU PERSONALLY HAVE ADDITIONAL
RESOURCES THEY MAY HAVE BEEN
DEPLETED DURING COVID FOR THINGS
LIKE, TUTORING OR EXTRA
ASSISTANCE IN THE HOME IN ORDER
FOR YOU AND YOUR SPOUSE TO BE AT
WORK WHILE CHILDREN NEEDED
SCHOOLING AND AS SOME OF THOSE
THINGS CLEARING IT'S A IMPORTANT
THINK ABOUT REGROUPING AND PART
OF THE WONDERFUL THING ABOUT
BIRCWH IS RELATIONSHIPS AND THE
CONFIDENCE THAT YOU HAVE AND IN
TURNING TO APPEAR OR MENTOR AND
SAY I FEEL STUPID UNDERSTANDING
AND I FEEL LIKE MY PROJECTOR MY
GRANT WILL BE BETTER, CAN YOU
HELP ME GET CONNECTED TO SOMEONE
WHO CAN FIGURE OUT A BETTER
METHOD AND THAT IS SO MUCH
HARDER, YOU CAN'T DO THAT ON THE
MARGINS OF A GROUP ZOOM CALL
WITH A DIRECTIVE TO REVIEW THIS
PORTION OF A MANUSCRIPT THIS
WEEK SO MY PERSONAL PASSION
RIGHT NOW, FOR THINKING ABOUT
HOW THINGS HAVE BEEN MORE
CHALLENGING AND HOW WE CAN GET
THEM BACK, IS TO GET THE HUMAN
ELEMENT BACK AGAIN.
I WOULD LOVE TO DO THE SURVEY
WITH BIRCWH CITES SO PLEASE
CONTACT ME AND SAY THAT WE'D
LIKE TO BE CONSIDERED FOR REDO
OF THE SURVEY AND THE SURVEY CAN
BE REFLESHED AND MORE MEANING
FIREFIGHTERS IT REFLECTED OUR
SITES.
THE LAS --MEANINGFUL.
WE DIDN'T THINK THE NUMBERS WERE
NEARLY GOING TO BE 25% OF PEOPLE
WITH CRAZY STUFF GOING ON IN
THEIR LIVES IN A YEAR THAT
DIRECTLY INVOLVED MEDICAL AND
HEALTH ISSUES.
WE ALSO DIDN'T ANTICIPATE THE
NUMBER OF SINGLE-FAMILY HOMES
AND WE COMPLETELY DIDN'T
ANTICIPATE THAT 5% OF OUR MALE
FACULTY WERE SINGLE
PARTICIPATING WITH SOLE CUSTODY
AND THEY'RE ABSOLUTELY INVISIBLE
AND ALL THE THINGS THAT HAVE PLY
TO WOMEN PARENTING, SOLO OR IN
FAMILIES AND HAVING
RESPONSIBILITIES FOR A LOT OF
DUTIES, APPLIED TO THAT GROUP
AND YOU TALK ABOUT A SILENT,
SMALL GROUP THEY'RE SILENT ABOUT
THEIR NEEDS AND WE HAVE GOTTEN
MORE PROACTIVE ABOUT FIGURE TAG
OUT TOO.
>> THANK YOU.
>> I WORK WITH Dr. BEG IN
SUPPORTING THE BIRCH PROGRAM SO
THANK YOU FOR YOUR WONDERFUL
TALK.
YOU TALKED ABOUT THE IMPORTANCE
OF COMMUNITY AND THE IMPACT OF
YOUR FELLOW TRAVELERS.
I JUST WANTED TO ASK IF CAN YOU
SHARE YOUR THOUGHTS IN THE
CONTEXT OF THE PIR PROGRAM AND
PART ONE, HOW THIS CAN MAKE THE
MOST OF THEIR TIME IN THE BIRCWH
AND NUMBER TWO, HOW ORWH CAN
SUPPORT BIRCWH SCHOLARS BETTER.
>> FLEXIBILITY AND PEOPLE TO DO
THINGS IN THEIR CAREER LIFE
THROUGH THEIR WORK BUDGETS THAT
SUPPORT.
>> I MADE MY PLUG TWICE IN THE
TALK AND WE'RE LET'S DO THIS
IN-PERSON.
I CAN'T IMAGINE IF I WAS THE
SCHOLAR 20 SOME ODD YEARS AGO I
WOULD HAVE MADE THE SAME
CONDITIONS IF I DIDN'T HAVE A
BOX LUNCH WITH PEOPLE AND TAKE
AN EXTRA DAY TO STAY OVER TO
TALK TO A PROGRAM OFFICER TO GET
A CLEARER IDEA ABOUT HOW THINGS
WORK AND I THINK THAT THAT IS
PART OF THE PERSONAL ELEMENT AND
THEN MAKING DECISIONS, ONE OF
THE THINGS THAT I'VE SEEN THAT
OTHER CAREER DEVELOPMENT
PROGRAMS HAVE DONE IS HAVING
GUEST LECTURE ACROSS SITES AND
ALLOWING OUR SCHOLARS TO BE ON A
ROSTER SHARING THEIR WORK AS
ANOTHER WAY TO CROSS POLLENATE
BECAUSE WE'RE NOT TOGETHER TO DO
THAT.
I'VE FOUND IT A LITTLE BIT CRAZY
THAT OUR DEPARTMENT AND OUR
DIVISION AND OUR ACADEMIC
INSTITUTIONS ARE WARM AND
FRIENDLY AND SUPPORTIVE PLACES,
SOMETIMES THEY'RE NOT AND
THEY'RE COMPETITIVE IN UGLY
PLACES BUT IF YOU ARE FORTUNATE
TO BE ONE THAT IS SUPPORTIVE, TO
THINK ABOUT WHAT MAKES IT WORK
AND TO SHARE THAT, AND BECAUSE
WE OFTEN HAVE WAYS TO DEAL WITH
A LEAVE FOR BEREAVEMENT OR WITH
MATERNITY AND WE HAVE ABSOLUTELY
NO PLANS FOR HOW TO DEAL WITH
THESE OTHER MUCH MORE COMMON
SORTS OF EFFORTS THAT WE IGNORE
O HAVING SOMEONE MOW YOUR LAWN
OR BRING A MEAL MIGHT BE MORE
IMPORTANT WHEN A CHILD IS
HOSPITALIZED OR A PARTNER THAT
IS SICK OR YOU ARE REALLY SICK.
THE ONLY WAY WE CAN DO THAT IS
KNOWING EACH OTHER WELL ENOUGH
TO FEEL COMFORTABLE BOTH WITHIN
OUR ACADEMIC STRUCTURES AND OUR
NEIGHBORHOODS AND TALKING ABOUT
HOW CAN I HELP AND HOW CAN THAT
FEEL NORMAL?
>> Dr. HARTMANN, THIS IS HELL
A WONG.
THANK YOU FOR THE PRESENTATIONS.
I LIKE IT AND I FEEL INSPIRED.
I HAVE A QUESTION.
OVER ALL PH.D AWARDEES IT'S
ACROSS THE BOARD AND I TRUST THE
BIRCWH PROGRAM WITH BIRCWH BEING
A PHYSICIAN SCIENTIST AWARD
PROGRAM, HOW CAN WE REACH OUT TO
CLINICIANS SCIENTISTS FROM THE
PROMOTING THE BIRCWH PROGRAM
IMPROVING RESEARCH IN WOMEN'S
HEALTH?
>> ABSOLUTELY.
I HOPE THAT WE'LL HAVE DATA SOON
THAT THESE SMALL INVESTMENTS
HELP WITH RETENTION AND KEEP
BEATING THAT DIAGRAM THAT
ASSISTANCE AND HELPFUL AND IT'S
PROBLEM MORE OUR MDs WHO TAKE
ADVANTAGE OF THAT AS WELL.
WHEN THERE'S A TIME CRUNCH AND
YOU ARE RIGHT, THE PRESSURES ON
PHYSICIAN AND PHYSICIAN
RESEARCHERS ARE DIFFERENT AND WE
USUALLY DIFFERENTIATE TOWARDS
THE RESEARCH TRACK PRETTY EARLY
AND I THINK THE MORE DIFFICULT
THING IS MECHANISMS TO PROVIDE
TRAINING FOR INDIVIDUALS WHO ARE
LATE BLOOMERS.
WHO DISCOVERED A FELLOWSHIP
PROJECT THAT THEY LOVE RESEARCH
AND THEY DIDN'T HAVE FORMAL
RESEARCH TRAINING.
IN REVIEW SESSIONS I'VE NOTICED
A TREND, NOT SO MUCH IN K12
REVIEW SECTIONS BUT INDIVIDUAL
REVIEW AND WE ARE HARSH ON THESE
LATENT TREMENDOUS PHYSICIANS.
AND IF THEY HAVE AGAIN TO THE
TROUBLE TO WORK WITH THEIR
LEADERSHIP TO GET PERMISSION AND
TO SATISFY THAT TIME TO SAY THAT
THEY'RE MAYBE NOT READY YET
BECAUSE THEY HAVEN'T DONE THE
MASTERS OF SCIENCE AND CLINICAL
INVESTIGATION OR THEY HAVEN'T
DONE THE MPH AND THAT'S NOT
SOMETHING THAT SHOULD BE COVERED
AND I KNOW IT'S NOT THE NIH
POSITION BUT REVIEWERS ARE SO
USED TO SEEING SUPER
SOPHISTICATED APPLICANTS THAT I
FEEL LIKE OFTEN THE MDs ARE
THE ONES THAT GET TRUMPED
PREMATURELY BECAUSE THEY'RE
SEEKING OPPORTUNITIES FOR
ADDITIONAL TRAINING.
I KNOW THAT'S NOT THE HEART OF
WHAT YOU WERE ASKING, THERE'S
BEEN A MULTI-DECADE CONCERN FOR
WHY WE LOSE CLINICIAN
RESEARCHERS AND IF T DEFINITELY
DOUBLED DOWN DURING COVID AND
WITH PEOPLE BEING REDEPLOYED IN
CLINICAL WAYS THAT THEY HADN'T
AND HAVING NEW DISTRACTION AND
NEW REQUIREMENTS AND ALSO, LOTS
OF NEW RESEARCH POTENTIAL TO
TAKE ON THAT TALKING MORE
CONCRETELY ABOUT WHAT DO YOU
NEED AND HOW CAN WE MAKE THAT
WORK FOR YOU IS HELPFUL.
IT MAY BE HELPFUL TO HAVE
CONVERSATIONS ABOUT IS IT
POSSIBLE TO TAKE LEAD FOR A
PERIOD OF TIME AND ONE OF THE
REGULATORY ISSUES AROUND THAT,
THEY ARE SUPER MURKY AND IT'S
HARD TO KNOW WHAT TO TELL PEOPLE
AND LATER ENTER TREE OF
CLINICIAN SCIENCES, MODEST WAYS
THAT WE CAN SUPPORT THEM AND
THEN GIVING THEM A VOICE FOR
ASKING FOR WHAT THEY NEED AND
BEING ABLE TO CONSIDER THAT, ONE
OF THE QUESTIONS DURING MY
REHEARSAL OF THIS TALK WAS TO
THE EFFECT OF, MY BOSS IS
INCREDIBLY GET YOUR TOUGH
TOGETHER AND PULL YOUR STUFF
TOGETHER AND MOVE ON.
I DON'T KNOW IF PEOPLE READ THAT
ATTITUDE RIGHT BUT SOMETIMES
WE'RE NOT PROACTIVE IN MENTORING
PEOPLE FROM WHAT TO ASK FOR.
OR WHAT TO ASSERT AS PART OF
THEIR PLAN TO GET THAT PROTECTED
TIME.
YOU SHOULDN'T AND IT'S ONE OF MY
JOBS AS ASSOCIATE DEAN AND VICE
PRESIDENT IN OUR RESEARCH
ENTERPRISE, YOU SHOULDN'T HAVE
TO FIGHT FOR YOUR 75% PROTECTED
TIME.
SOMEONE SHOULD ENFORCE THAT FOR
YOU AND SOMEONE SHOULD COACH YOU
UP ABOUT WHAT IT MEANS CAN YOU
PUT DOWN AND WHAT IT MEANS THAT
YOU SHOULD ASK TO BE ALLOWED TO
PUT DOWN SO YOU ARE FINANCE THAT
PLACE OF TRYING TO WORK AROUND
THE EFFORT AND WHEN YOU ARE GET
WHAT IS YOU DESERVE AND TO
LAUNCH YOUR CAREER AS A
PHYSICIAN SCIENTIST HOW TO HAVE
THE CONVERSATIONS I PLAN TO NOT
DO THESE THINGS AND I WOULD LIKE
PERMISSION TO NOT DO THESE OTHER
THINGS OR DELAY DOING THESE
THINGS AND WOULD IT BE POSSIBLE
TO MAKE THESE CHANGES AND IT
HAPPENS FOR CAREER DEVELOPMENT
AWARDS AND WE NEED TO REINFORCE
THAT AS MENTORS AND WE'RE THERE
TO PROTECT PEOPLE TO MAKE SURE
THEY IT WAS AMAZING IT PROTECTED
THEIR CAREER AND HELPED THEM
GROW FABULOUS AND NEW DURING THE
TIME THAT THEY WERE ON THE VERGE
VERGE.
>> AT THE THANK YOU SO MUCH FOR
GETTING THE 2022 RUTH L
KIRSCHSTEIN MEMORIAL LECTURE.
WE KNOW, SHE WAS AN ICON AND
WELL RESPECTED AND THIS IS A
VERY IMPORTANT LECTURE GIVEN
ANNUALLY DURING THE BIRCWH
MEETING AND WE APPRECIATE YOUR
THOUGHTFUL AND CONSIDERATE
LECTURE, THANK YOU.
>> I'M ABSOLUTELY HONORED TO BE
WITH YOU TODAY AND I APPRECIATE
IT.
>> THANK YOU SO MUCH.
GREAT JOB.
>> FOLLOWING Dr. HARTMANN'S
TALK WE HAVE Dr. CLAYTON IN
THE CAREER GROUP AND THEY HAVE
ADDED A NEW SESSION FOR THIS
ANNUAL MEETING AND BECAUSE
THERE'S BEEN SO MANY POSITIVE,
EXCITING DEVELOPMENTS WITH ORWH
AND THESE THREE IMPACT THE BIRCH
PROGRAMS SO FOR THE NEXT HOUR,
THERE'S GOING TO BE THREE
20-MINUTE, THREE-15 MINUTE TALKS
FOR FIVE MINUTES WITH Q&A AFTER
EACH ONE SO YOU CAN GET CAUGHT
UP ON THIS AND SO I'M GOING TO
TURN IT OVER TO Dr. XENIA
TIGNO FOR THE FIRST SESSION THAT
SHE WILL HOST WITH Dr. HOLLY
MOORE.
Dr. TIGNO.
>> THANK YOU Dr. BEGG.
GOOD MORNING, EVERYBODY.
MY NAME IS XENIA TIGNO AND AS
THIS IS THE ASSOCIATE DIRECTOR
FOR CAREER OF THE OFFICE OF
RESEARCH IN WOMEN'S HEALTH AND
ONE OF THE DELIGHTS OF BEING IN
THIS POSITION IS LEADING THE
EFFORTS OF THE NIH WIDE WORKING
GROUP ON WOMEN IN MY MEDICAL
CAREER.
THIS YEAR, THE PARTNERSHIP'S
COMMITTEE OF THE WORKING GROUP,
HOSTED A SUMMIT THAT CHALLENGED
THE CURRENT RESPECTIVE OF HOW
WOMEN SCIENTIST CAREER
TRAJECTORY SHOULD LIKE LIKE AND
OTHER STEM SCIENTISTS AS WELL.
IT GIVES ME GREAT PLEASURE TO
INTRODUCE HOLLY MOORE FROM THE
NATIONAL INSTITUTE OF DRUG
ABUSE, WHO IN ADDITION TO CO
CHAIRING THIS SUMMIT, ALSO
CONTRIBUTES LEADERSHIP TO
NUMEROUNUMEROUS TRANS NIH PROGRAMS.
HOLLY IS TRAINED IN PSYCHOLOGY,
CHEMISTRY AND NEUROSCIENCE AND
WAS FACULTY AT THE COLOMBIA
UNIVERSITY PRIOR TO JOINING THE
NIH.
MOST IMPORTANTLY, SHE IS AN
EMPATHETIC AND INTENSE LEADER
WHO EMPOWERS AND ELEVATES ALL
PERSONS WITH WHOM SHE INTERACTS.
SHE WILL BE SHARING WITH YOU
SOME OF THE HIGHLIGHTS OF THAT
SUMMIT.
>> HELLO, I'M HOLLY MOORE ON
DRUG ABUSE AND CO-CHAIR OF THE
PARTNERSHIP GROUPS WITHIN NIH'S
WORKING GROUP ON WOMEN IN
BIOMEDICAL CAREERS.
I'M HERE ON BEHALF OF MY
CO-CHAIR AND CHAIR A AS WELL AS
THE MEMBERS OF OUR GROUP SHOWN
ON THIS SLIDE.
OUR GROUP'S VISION IS A BIO
MEDICAL SCIENCE TECHNOLOGY AND
ENGINEERING MATH AND DATA FOR
STEM WHERE DIVERSE AND
INNOVATION SPECIFICS LENS AND
WE'RE EVER PERSON MAY CHOSE A
CAREER TO MAXIMIZE THEIR
POTENTIAL AND OF ALL IDENTITIES
FROM BACKGROUNDS OF ALL
COMMUNITIES AND ALL CULTURES.
WE HAVE A MULTI-SECTOR ECOSYSTEM
AT PRESENT AND IT'S RELATIVELY
SEGREGATED.
THOSE OF US WHO PURSUE A CAREER
TEND TO START IN ONE SECTOR AND
STAY THERE AND GROW WITHIN THAT
SECTOR TO THE EXTENT AND MANY OF
US DON'T HAVE ACCESS TO OR ARE
UNAWARE OF WAYS TO CROSS FROM
ONE SECTOR TO ANOTHER ALTHOUGH
THEY EXIST.
OFTEN FOR WOMEN AND PEOPLE
COMING FROM UNDER REPRESENTED
COMMUNITIES, WE COME TO OUR
CAREER WITH NON LINEAR OR
UNTRADITIONAL PATHS AND IT'S
ALSO THE CASE THAT LIFE
EXPERIENCES WILL INTERRUPT OUR
CAREER ACTIVITIES IN OUR GIVEN
SECTOR AND ALL THOSE EXPERIENCES
ACTUALLY DON'T LIMIT OUR OWN
GROWTH, THEY LIMIT OUR
OPPORTUNITIES AND IT'S THE CASE
IF WE START AT ONE SECTOR AND
FIND THAT WE ACTUALLY GROW MORE
IF WE CAN CROSS OVER TO A
DIFFERENT SECTOR TO TAKE
ADVANTAGE OF AN OPPORTUNITY OR A
JOB OPPORTUNITY AND IT'S THE
CASE THAT THAT MAXIMIZES THEIR
GROWTH.
WE'VE STARTED THIS CONVERSATION
AND WE DID THAT EARLIER THIS
YEAR WITH THE SUMMIT.
REIMAGINING WOMEN IN THE BIO
ENGINEERING TECHNOLOGY AND DATA
SCIENCE ECOSYSTEM.
THE GOALS OF IS THE SUMMIT WERE
TO GATHER TO SHARE IDEAS AND
DATA AND THE CHARTER AND
COMPONENTS OF A HEALTHY STEM
ECOSYSTEM AND IN TURN
PARTNERSHIP THAT'S BUILD THIS
HEALTHY ECOSYSTEM WE FOCUSED ON
MID CAREER WOMEN BECAUSE IT'S AN
EXAMPLE RIGHT NOW OF AN
OPPORTUNITY BOTTLENECK AND WE
CAN CREATE IDEAS TO OPEN UP
OPPORTUNITIES THERE, AT THAT
BOTTLENECK WE HOPE TO EXPEND
THOSE IDEAS TO OPEN UP THE
OPPORTUNITIES THINGS ACROSS THE
CAREER TRAJECTORY FOR ALL
COMMUNITIES.
WE HAVE FIVE EMPHASIS AREAS.
WOMEN IN INVENTORS,
EDUCATIONORS, PARTNERSHIPS, ALLY
SHIP, MENTORSHIP AND SPONSORSHIP
FOR WOMEN AND WEALTH AND
OPPORTUNITY GAPS AND OUR THEMES
WERE NEXTALITY, LEADERSHIP AND
CARE OF OTHERS.
WE HAD EXPERTISE IN DATA AND
SCIENCE INFORMATION, NURSE,
BIOMEDICAL SCIENCES AND BIO
ENGINEERING AND THEY SHOW THE
PIE CHART HERE TO THE RIGHT
INCLUDING CHAIRS OF BIO
ENGINEERING AND TECHNOLOGY
DEPARTMENTS FROM RULES AND OTHER
UNIVERSITIES.
THEY ASKED OUR STEM LEADERS TO
GIVE US A STATE ASSESSMENT OF
THE ECOSYSTEM AND THE STEM
ECOSYSTEM AS IT EXISTS TODAY AND
TELL THEM WHAT IT'S LIKE FOR
YOUR TRAINEE AND THEN WE ASKED
THEM FOR IDEAS FOR THERE ARE A
FEW BIG TAKEAWAYS.
THE GENDER, RACIAL AND EQUITY
AND CULTURAL DIVERSITY IS
INDISPUTABLE.
WE PERFORM ACROSS PRIVATE AND
PUBLIC SECTOR AND WOMEN FROM
PEOPLE UNDER REPRESENTED
IDENTITIES AND COMMUNITIES
PERFORM AT LEVELS THAT ARE
EQUALLY TO OR SUPERIOR IN
RELATIVE TO THEIR MAJORITY GROUP
PEERS AND THERE'S DATA NOW TO
SUPPORT THE IDEA THAT DIVERSITY
AND EQUITY PROMOTE INNOVATION
AND IMPACT AND WITHIN THE WORLD
OF VENTURE CAPITAL, MINORITY
FOUNDED COMPANIES PERFORMED ON
BAR OR BETTER THAN THE
PORTFOLIOS THAT VENTURE CAPITAL.
IN SMALL AND LARGE BUSINESS
INDUCE TREMENDOUS COMPANIES IN
THE TOP FOR GENDER AND RACIAL
AND ETHNIC DIVERSITY ARE MORE
LIKELY TO HAVE RETURNS THAT ARE
ABOVE THE INDUSTRY MAIN AND
WHETHER IT'S AN ACADEMIA, FARM
OR GOVERNMENT DIVERSE TEAMS HAVE
MORE HIGH-IMPACT DELIVERABLES
AND IT'S NOW BEEN SHOWN THAT THE
MINORITY MEMBERS INDIVIDUAL
CONTRIBUTIONS ON THOSE TEAMS ARE
KEY TO THAT INCREASED
INNOVATION.
WE ALSO FACED BARRIERS EX
CHALLENGE AND WE GET LESS CREDIT
AND INVESTMENT DESPITE EQUAL OR
SUPERIOR PERFORMANCE AND WITHIN
THOSE HIGH PERFORMING I DO VERSE
TEAMS THAT I JUST TALK ABOUT THE
PREVIOUS SLIDE, PLENTY OF CREDIT
GOES TO THE TEAM FOR BEING
DIVERSE AND PRODUCING INNOVATION
BUT WHEN IT COMES TO GIVING
CREDIT, THAT GOES TO THE
MAJORITY GROUP INDIVIDUALS ON
THAT TEAM AND NOT THE DIVERSITY
MEMBERS OF THE WE FACE WELCOMING
ENVIRONMENTS IN BIAS AND
STRUCTURES IN THE STEM WORKPLACE
AND WE ALSO PAY AN OUTREACH
TASK.
WE TAKE ON THE BURDEN FOR OUR
GROUP IN THE WORKPLACE AND WE'RE
EFFECTED BY THE RICH GET RICHER
EFFECT AND THAT LIMITS OUR
BANDWIDTH AND OPPORTUNITIES AND
WE ACTUALLY HAVE TO FACE
GEOGRAPHIC AND PERSONAL RESOURCE
AND WE'RE EFFECTED BY A SCARCE
MENTALITY THAT IS HELD BY THE
MAJORITY MEMBERS OF OUR
WORKPLACE AND IN THAT THERE'S
ONLY SO MUCH TO GO AROUND AND BE
HAPPY WITH THE SLICE OF THE PIE
THAT YOU HAVE AND SHARE IT WITH
OTHERS IN YOUR GROUP.
FINALLY, THERE ARE HIGH PERSONAL
COSTS TO WOMEN IN PEOPLE FROM
UNDER REPRESENTED COMMUNITIES TO
CLIMB TO THE TOP WHERE WE WANT
TO GET THERE.
WE WANT TO MAKE A DIFFERENCE
FROM THE TOP AND CHANGE FROM THE
TOP BUT THE HIGH COST OF
CLIMBING ARE RELATED TO THE
POINTS ABOVE THAT I JUST TALKED
ABOUT AND WHEN WE GET TO THE
TOP, WE FIND LOWER DIVERSITY AND
HIGHER BARRIERS TO DIVERSITY AND
EQUITY AND MORE INERTIA WITH
REGARDS TO CHANGING THINGS AND
WE ALSO TALKED ABOUT WHAT WORKS.
WE THRIVE IN MULTI-LEVEL
MENTORING ALLY SHIP AND
SPONSORSHIP.
FOR EXAMPLE, WOMEN AND STEM
CAREER WITH SPONSORS ARE MORE
LIKELY TO BE SATISFIED WITH
THEIR BIG PROMOTION AND ASK FOR
A RAISE AND TO HAVE THEIR IDEAS
ENDORSED, DEVELOPED AND MUCH
MORE LIKELY TO HAVE THEIR IDEAS
IMPLEMENTED.
HERE ARE A FEW QUOTES THAT I'LL
SHARE WITH YOU AND I'LL SHARE
THESE SLIDES SO YOU CAN SEE
THESE QUOTES IN THE SLIDES THAT
IF YOU LIKE BUT I WANT TO POINT
OUT FOR WOMEN AND OTHER PEOPLE
AND FOR MANY PEOPLE IN STEM D
AND IF THEY CHOSE TO STAY IN
STEM D THEIR GROWTH IS NOT
LINEAR.
WE HAVE OUR CAREERS THAT WERE
ALSO HAPPENING AND WE NEED WORK
IN COLLABORATIVE SPACE AND HERE
ARE A FEW OTHER QUOTES.
NAMELY OR I'LL HIGHLIGHT THIS
WHEN WE CAN'T CLOSE THE WEALTH
GAP UNTIL WE HAVE MEN IN
MAJORITY GROUPS AT THE TABLE
WITH US AND WE NEED
ACCOUNTABILITY AND TRANSPARENCY
AND WE NEED THE THREE Rs,
RELATIONSHIP, RESOURCE AND
RECOGNITION AND A FEW MORE, THE
BIG ONE I'LL HIGHLIGHT HERE AND
THAT IT'S AMAZING HOW INNOVATIVE
SCIENTIST AND ENGINEERS ARE AND
BASICALLY RECORDING THE WHOLE
COMMUNITY WITH THIS AND IT'S
AMAZING HOW INNOVATIVE WE CAN BE
WHEN IT COMES TO OUR OWN SCIENCE
AND ENGINEERING AND HOW REAL
INNOVATION WE CAN CONTRIBUTE OR
ACTUALLY SPEND ON BUILDING THE
ECOSYSTEM THAT SUPPORTS THE
PEOPLE WHO DO THE WORK.
WE NEED TO ACTUALLY INNOVATE
WITH REGARD TO WHO WE'RE
SUPPORTING AND HOW WE'RE
DEVELOPING SCIENTISTS AND
ENGINEERS.
THE FINAL SET OF IDEAS FOR
ACTION THAT ARE REALLY ABOUT THE
NECESSARY ELEMENTS OF A HEALTHY
MULTI SECTOR STEM TO ECOSYSTEM.
YOU NEED A COMMITMENT TO
DIVERSITY INCLUES AND AND NOT
JUST REFLECT THE PRESENT AND WE
NEED SUSTAINABLE EXPERIENCE AND
MOBILITY ACROSS STEM DIS
SCEPTERS AND NETWORKS THAT
CONNECT PEOPLE ACROSS -- ALL
PEOPLE IN ALL SECTORS OF STEM D
AND WE NEED TO SUPPORT NON
LINEAR CAREER GROWTH AND
VOCATIONAL GROWTH WHICH MEANS
WHEN SOMEONE HAS TO ACTUALLY
EXIT TEMPORARILY, FROM THEIR
CAREER PATH, DUE TO A LIFE
EXPERIENCE, OR FOR OTHER
RESPONSIBILITIES, WE NEED LOWER
BARRIERS TO REENTRY.
WE WANT AND NEED THE SYSTEM THAT
IS A SET OF GROWTH VARIANCE
GAINED FROM NON LINEAR PATHS AND
LIFE EXPERIENCES AND WE NEED
OPPORTUNITIES TO SHARE SUCCESS
AND HELP OTHERS GROUP AND WE
WANT TO REPLACEMENT OF A SYSTEM
BASED ON PAST CREDIT WITH A
GROWTH-FOCUSED VALUE SYSTEM AND
WE NEED SYSTEMS THAT SUPPORT
RISK TAKING AND AT THE LEVEL OF
THE TEAM WITH THE INSTITUTION
AND MITIGATING RISKS AT THE
LEVEL OF INDIVIDUAL.
WE WANT METRICS THAT REFLECT
VALUES OF DIEA GROWTH AND
OVATION THROUGH COLLABORATION
AND WE WANT MILES FOR ALLY SHIP,
MENTORSHIP AND SPENCE O ACROSS THE SPAN.
NOW WE WANT ANOTHER PERSPECTIVE
AND THAT'S YOURS.
AND I'M GOING TO LEAVE YOU WITH
Dr. XENIA TIGNO WHO WILL ASK
OR ASK YOU TO THINK ABOUT THE
FOLLOWING QUESTIONS, WE'RE
CHALLENGING YOU TO IMAGINE YOUR
CAREER PATH IN A HEALTHY STEM
ECHO SYSTEM AND CONSIDER THE
QUESTIONS ON THIS SLIDE AND
DISCUSS TODAY AND OR CONTACT US
AT THE BOTTOM AND THANK YOU.
>> THANK YOU, Dr. MOORE.
THE QUESTIONS AT THE END OF THE
PRESENTATION OF Dr. MOORE ARE
REALLY INTENDED TO PROVOKE YOUR
MENTALLATION AND THE
PARTNERSHIPS COMMITTEE WOULD
LOVE TO HEAR YOUR THOUGHTS.
THE E-MAIL LINK IS PROVIDED AND
JUST IN CASE YOU NEED MORE TIME
TO COMPOSE YOUR THOUGHTS, FEEL
FREE TO SEND THEM TO THAT
E-MAIL.
JOINING ME IN THIS SESSION ARE
TWO OF OUR DIS TINNISHED BIRCWH
PV, SUSAN KORNSTEIN AND JUDITH
REGENSTEINER OF THE UNIVERSITY
OF COLORADO WHO WILL MODERATE
THIS SESSION.
>> THANK YOU.
>> THANK YOU SO MUCH.
I WILL START.
I WAS ASKED TO MAKE COMMENTS ON
HOLLY'S TALK SO I WANT TO POINT
OUT THIS SUMMIT IS PART OF A
BROADER EFFORT BY NIH AND THE
NATIONAL ACADEMIES TO ADDRESS
THE UNDER REPRESENTATION OF
WOMEN IN THIS STEM D WORKFORCE
AND TO SUPPOSE SORT THEIR FULL
PARTICIPATION AND ADVANCEMENT
AND ADVANCING DIVERSITY CAN
EQUITY IN THE SCIENTIFIC
WORKFORCE WAS A MAJOR FOCUS OF
THE SUMMIT AND CREATING AN
ECOSYSTEM IN WHICH ALL
SCIENTISTS ONE THE MAIN
TAKEAWAYS FOR ME IS
COLLABORATION ACROSS SECTORS IN
THE SCIENTIFIC RESEARCH
ECOSYSTEM CAN BE TRANSFORMATIVE
AND DISRUPTIVE AND THAT IT CAN
GENERATE INNOVATION THAT WOULD
NOT BE POSSIBLE IN ONE SECTOR
ALONE.
IT'S A SIMILAR ARGUMENT TO WHY
WE PROMOTE AND AND THIS IS
TAKING IT TO A BROADER LEVEL TO
INCLUDE OTHER SECTORS BESIDES
ACADEMIA.
AND I CAN TELL YOU THAT AS A
CLINICAL RESEARCHER, I HAVE
ALWAYS FELT THAT PARTNERSHIP
BETWEEN ACADEMIA AND INDUSTRY IS
CRITICAL TO ADVANCING SCIENCE
AND I'VE COLLABORATED WITH
SEVERAL PHARMACEUTICAL COMPANIES
OVER THE COURSE OF MY CAREER TO
DESIGN AND CONDUCT CLINICAL
TRIALS.
AND THERE WERE TIMES THAT I EVEN
TOYED WITH THE IDEA OF TAKING A
POSITION IN INDUSTRY AND I
ALWAYS FOUND IT TO BE MUCH MORE
FULFILLING FOR ME TO STAY IN
ACADEMIA AND SOME OF THE
RESEARCH THAT I WAS PART OF WITH
THESE INDUSTRY COLLABORATIONS
WAS REALLY IMPORTANT AND SOME OF
OUR STUDIES WERE PUBLISHED IN
"THE NEW ENGLAND JOURNAL" OF
MEDICINE AND JAMA AND THE BEST
EXTOL I KNOW IS BARBRA BOY AN MY
CO PI ON MY BIRCWH GRANT.
SHE'S . MEDICAL ENGINEER AND
SHE'S AN INTERNATIONALLY
RECOGNIZED WOMEN'S HEALTH
RESEARCHER AND SHE'S IN THE
NATIONAL ACADEMY OF ENGINEERING
AND THE NATIONAL ACADEMY OF
INVENTORS AND SHE WAS DEAN OF
OUR COLLEGE OF ENGINEERING AND
CURRENTLY DIRECTS OUR INSTITUTE
FOR ENGINEERING AND MEDICINE.
BARBRA HAS COLLABORATED
EXTENSIVELY WITH MANY DIFFERENT
SECTORS AND THE ECOSYSTEM
THROUGH OUT HER CAREER AND SHE
HAS CO FOUNDED FOUR COMPANIES,
SHE HAS 24 PATENTS, AND SHE SITS
ON THE BOARD OF SEVERAL
COMPANIES, ALL WHILE STAYING IN
ACADEMIA.
SHE'S DEMONSTRATED WHAT THE
SUMMIT IS ABOUT AND SHE'S LIVED
IT AND SHE'S ALSO MEN FORWARD TO
LOTS AND LOTS OF WOMENNEN
GUINEARS AND SCIENTISTS ALL
ALONG THE WAY.
SO HOLLY PRESENTED TO US SOME OF
THE RECOMMENDATIONS FROM THE
THOUGHT LEADERS WHO ATTENDED THE
SUMMIT BUT WHAT THE GROUP IS
LOOKING FOR NOW TO GET FEEDBACK
FROM THE STAKEHOLDERS.
SO THEY WANTED TO HEAR FROM
BIRCWH SCHOLARS AND MENTORS WHO
ARE WORKING IN THIS SPACE, HOW
CAN WE, AS BIRCWH PROGRAMS,
PARTICIPATE IN THAT INNOVATION.
SO I WILL LEAVE YOU WITH THAT TO
THINK ABOUT AND I WILL TURN IT
OVER TO JUDY TO MAKE HER
REMARKS.
>> THANK YOU, SUSAN.
GREAT THOUGHTS WHICH I WOULD
ECHO AT OUR INSTITUTION.
WE HAVE A NEW DEPARTMENT OF
HEALTH ARTIFICIAL INTELLIGENCE
AND A BIG FOCUS TO THAT AREA
WHICH YEARS AGO WASN'T EVEN A
THOUGHT SO THERE'S A LOT OF
OPPORTUNITY ARISING IN THE AREAS
OF DATA SCIENCE AND ENGINEERING
AND SOME OF OUR TOP SCIENTISTS
AT THE CENTER ARE BIO ENGINEERS
NOW SO IT'S EXCITING GROWTH AND
DEVELOPMENT WITH ROOM FOR
TRADITIONAL FORMS OF SCIENCE AND
NEW FORMS OR TYPES OF SCIENCE
AND SO WE WANT TO ASK YOU, WE
WANT TO HAVE THIS BE AN
INTERACTIVE SESSION WHERE YOU
WERE ABLE TO PLACE QUESTIONS IN
THE CHAT.
WE WISH WE WERE IN-PERSON
TALKING TO YOU BUT WE'RE NOT.
SO ANYWAY, PLEASE ASK YOUR
QUESTIONS.
THE FIRST QUESTION WE WOULD LIKE
TO POSE TO YOU AND THE WHOLE
LIST OF QUESTIONS WAS ON THE
SLIDE IN THE PRESENTATION WHICH
YOU CAN LOOK AT AND ADDRESS AND
FOR THIS DISCUSSION, HOW COULD
THE SCIENTIFIC RESEARCH AND DATA
SCIENCE AND ENGINEER BETTER
SUPPORT YOU TO BE THE EDUCATOR
AND SCIENTIST, AND ENGINEER, AND
ADMINISTRATOR THAT YOU WANT TO
BE.
SO HOW CAN THE ECOSYSTEM SUPPORT
YOU?
I HAVE ONE YOUNG SCIENTIST/BIO
ENGINEER AND SHE WENT TO
INDUSTRY AND SHE REALIZED IT WAS
NOT FOR HER AND SHE'S BACK AT
UNIVERSITY AND AN ACADEMIC
WRITING GRANTS AND GETTING
PATENTS AND INVENTING AND HAPPY
IN THAT ENVIRONMENT SO THERE'S A
LOT OF OPPORTUNITIES.
THE OTHER QUESTION WE HAVE IS
WHAT WOULD MAKE IT MORE LIKELY
FOR YOU TO TRANSLATE AND
COMMERCIALIZE YOUR WORK WHICH IS
POSSIBLE FOR MANY FORMS OF
SCIENCE AND PARTNER WITH STEM
FOLKS OUTSIDE YOUR SECTOR.
WE WANT TO MAKE THIS AREA MORE
TRANSLATABLE TO YOUR LIVES.
I HAD ONE SCIENTIST WHO HAD AN
INVENTION IDEA BUT SHE COULDN'T
FIND ANYONE TO TALK TO HER AND
WE WERE ABLE TO CONDUCT HER TO
THE INNOVATIONS OFFICE WHICH
MOST UNIVERSITIES HAVE THESE
DAYS AND SHE WAS ABLE TO GO
AFTER A PATENT SO, LOTS OF
OPPORTUNITIES SO WHAT ARE YOUR
QUESTIONS ABOUT THIS BIRCWH
SCHOLARS?
DO WE HAVE ANY BIO ENGINEERS IN
THE AUDIENCE?
I BET WE DO THAT MIGHT WANT TO
COMMENT ON THEIR EXPERIENCE.
I'M CURIOUS, DO WE KNOW HOW MANY
BIRCWH SCHOLARS ARE BIO
ENGINEERS OR DATA SIGNIST XENIA
OR LISA, I'M JUST CURIOUS, NOT
PUTTING YOU ON THE SPOT?
>> LISA, WOULD YOU HAVE ANY
IDEA?
>> HI, THIS IS LISA.
SO WE HAVE, WE PROBABLY HAVE
FIVE AND THERE'S ALWAYS A FEW.
THEY'RE USUALLY INDIVIDUAL BIO
ENGINEERS OF INDIVIDUAL
PROGRAMS.
WE HAVE AT LEAST FIVE ACTIVE
WITHIN THE LAST COUPLE OF YEARS.
>> SO TELL US YOUR EXPERIENCE
YOU FIVE, WE WITH LOVE TO HEAR.
HOPEFULLY WE'RE PROVOKING
THOUGHT SO EVEN IF PEOPLE AREN'T
PARTICIPATING RIGHT NOW, I HOPE
YOU WILL THINK ABOUT IT AND GIVE
US YOUR THOUGHTS.
>> I WANT TO REINFORCE AGAIN TO
THE AUDIENCE, BECAUSE WE WILL
NOT BE ABLE TO HAVE A THOROUGH
DISCUSSION OF THESE IMPORTANT
QUESTIONS IS WE INVITE YOU AND
ENCOURAGE YOU TO E-MAIL US AND
SO THAT WE CAN SET UP A DIALOGUE
AND THERE'S ALSO THE LINK FOR
THE FULL EXECUTIVE SUMMARY.
SHE HAD A CAREER WITH IT'S
INDULGENT OF HER NEED TO SEE
BASIC SIGNS AND FINDINGS BE
CONVERTED INTO PRODUCTS THAT
HELP PEOPLE IN THE POST COVID
WORLD, HOW CAN NIH AND BIRCWH
SUPPORT THE GROWTH OF OUR
FACULTY FOCUS ON WOMEN'S HEALTH
AND SEE THE EFFORTS GO FORWARD
SO AND THOUGHT PROVOKING
QUESTIONS AND THEN WE HAVE A
BIRCWH SCHOLAR SAYING SHE'S
IDENTIFYING HERSELF AND I HOPE I
DIDN'T BUTCHER YOUR NAME AND MAY
I ASK YOU, WHICH ARE YOU?
>> CAN I ADD TOO THAT EVEN
THOUGH THIS WAS A SUMMIT
FOCUSING ON DATA SCIENCE AND BIO
ENGINEERING THIS CROSS SECTORAL
APPROACH IS APPLICABLE TO ZOO
SCIENTISTS, NOT THOSE WHO ARE IN
THE DATA SCIENCE.
OR BIO ENGINEERING.
>> ABSOLUTELY.
BASIC SCIENTIST MIGHT COME UP
WITH A MOLECULE THAT MIGHT TURN
INTO A MEDICINE THAT HAS
HAPPENED AND IS VERY PALPABLE.
>> WELL, IT LOOKS LIKE WE'RE NOT
GETTING MUCH FEEDBACK SO ANY
FURTHER THOUGHTS, Dr.
KORNSTEIN.
>> I THINK WE'RE OUT OF TIME?
I THINK.
>> YES.
>> TWO MORE MINUTES I THINK.
>> OK, NOW I THINK THAT POINT
WAS VERY WELL TAKEN THAT THIS
DOES NOT APPLY TO ENGINEER AND I
THINK THAT THE IDEA OF CROSS
SECTOR COLLABORATION IS ALL
SCIENTISTS AND ALL AREAS AND I
THINK THAT EVERYONE SHOULD BE
THINKING ABOUT HOW THEY CAN
PARTNER WITH INDUCE TREMENDOUS
AND THE GOVERNMENT AND NON
PROFITS AND ALL THESE OTHER SUCK
TOURS THASECTORS.>> MEANWHILE, SHE'S A BY OWE
MEDICAL ENGINEER AND A DATA
SCIENTIST AND SHE IS VERY LUCKY
WITH HER MENTORS WHO ARE
SUPPORTIVE SO THAT'S GOOD TO
HEAR.
AND NOT SURPRISING AT A BIRCWH
MEETING WHERE MENTORSHIP HAS
SENT IT TO ALL OF US.
THANK YOU, EVERYBODY.
AND HOPEFULLY WE WERE
THOUGHT-PROVOKING AND YOU WILL
RESPOND, BIRCWH SCHOLARS YOU CAN
RESPOND IN WRITING AND NIH IS
CERTAINLY INTERESTED IN
GATHERING YOUR THOUGHTS AND
FEEDBACK BECAUSE IT HELPS US IN
OUR DEVELOPMENT OF PROGRAMS.
>> THANK YOU, VERY MUCH, Dr.
KORNSTEEN AND Dr. REGENSTINER
FOR JOINING US.
>> IF WE COULD MOVE ONTO THE
NEXT SLIDE.
I'D LIKE TO INTRODUCE OUR SECOND
SPEAKER, Dr. KATHLEEN BRADY IS
LITERALLY THE DISTINGUISHED
PROFESSOR OF PSYCHIATRY AND
HOLDS A M D AND PH.D AND SHE'S
HAD A LONG HISTORY OF SUCCESSFUL
RESEARCH SUPPORTED BY NIH AND IN
SUBSTANCE USE DISORDERS AND
TRANSLATIONAL RESEARCH AND
SPECTRUM ACROSS THE U.S. AND SHE
FOCUSES ALONG ON NEW THERAPIES
FOR THESE CONDITIONS AND SHE
CURRENTLY I TURN IT OVER TO
Dr. BRADY.
>> THANK YOU, VERY MUCH.
AND I'M HERE TODAY TO TALK ABOUT
A NEW PROGRAM AND IT'S AN
ADMINISTRATIVE SUPPLEMENT TO THE
MUSC SCORE GRANT BUT IT IS TO
OFFER SOME EXTRA EDUCATIONAL
RESOURCES TO THE CURRENT BIRCWH
SCHOLARS AND WE'RE CALLING IT
THE BIRCWH SCHOLAR INNOVATION
PROGRAM.
AS I SAID, IT'S AN
ADMINISTRATIVE SUPPLEMENT TO OUR
CURRENT SCORE AS YOU GUYS KNOW,
SPECIALIZED CENTER FOCUSED ON
GENDER STUDIES, OURS IS IN THE
AREA OF STRESS AND SUBSTANCE USE
DISORDERS AND THE PURPOSE OF
THIS ADMINISTRATIVE SUPPLEMENT
IS TO PROVIDE TRAINING AND
MENTORSHIP IN THE CRITICAL AREAS
OF SUBSTANCE USE DISORDERS AND
MENTAL HEALTH DISORDERS,
PARTICULARLY THOSE THAT CO OCCUR
COMMONLY WITH SUBSTANCE ABUSE
AND THE AREA OF WOMEN'S HEALTH
AND THAT INTERSECTION THERE.
WE'RE GOING TO BE TARGETING
BIRCWH SCHOLARS BUT ALSO OPENING
IT UP AND THE SCORE ALSO HAS A
CAREER ENHANCEMENT CORE AND WE
ARE GOING TO IN TWO OR THREE
SCORE SCHOLARS ARE SELECTED
EVERY YEAR FOR THAT SO WE WILL,
THOSE SCORE CEC SCHOLARS
INTERESTED WILL ALSO BE INVITED
TO PARTICIPATE.
SO, THERE ARE REALLY THREE AIMS
AND THE FIRST IS TO DEVELOP BY
DIDACTIC SERIES AND AN ON-LINE
TRAINING EXPERIENCE FOR A
SYNCHRONOUS LEARNING THAT IS
FOCUSED ON GENDER DIFFERENCES
AND SUBSTANCE USE DISORDERS AND
MENTAL HEALTH ISSUES RELATED TO
SUBSTANCE USE DISORDERS
THROUGHOUT THE LIFESPAN.
WE WILL HAVE A FOCUS ON UNDER
REPRESENTATIVE AND UNDERSERVED
POPULATIONS AND DIVERSITY IN
SUBSTANCE USE DISORDER RESEARCH
AND AIM TWO, IS A CONSULTATIVE
AND MENTORING SYSTEM TO ALLOW
BIRCWH SCHOLARS TO WORK WITH
MUSC SCORE INVESTIGATORS AND
INCLUDING VISITS TO MUSC OR WILL
SUPPORT TRAVEL TO NATIONAL
MEETINGS WHERE NETWORKING AND
COLLABORATIONS MIGHT BE
ESTABLISHED.
AND THEN AIM THREE, WE WILL
OFFER GRANT REVIEW AND MOCK
STUDY SECTIONS FOR BIRCWH
SCHOLARS WHO ARE SUBMITTING
GRANTS FOCUSED IN THIS SPECIFIC
SEX GENDER DIFFERENCES AND
MENTAL HEALTH SUBSTANCE USE
DISORDERS SO WORE GOING TO HAVE
A DIDACTIC SERIES AND MENTORING
SYSTEM AND SKILL DEVELOPMENT.
SO, PHASE 1 AND YOU CAN EXPECT
OUR WEBSITE TO BE UP IN JANUARY
OF 2023.
WE'RE GOING TO BEGIN WITH THIS
MONTHLY DIDACTIC SERIES WITH
LEADING EXPERTS AND WE'LL BASE
IT ON THE ECHO MODEL WHICH I'LL
DESCRIBE IN A MINUTE.
THIS SURVEY WILL GO OUT IN THE
NEXT WEEK OR TWO AND WE'LL
ASSESS THE NEEDS OF THE
TRAININGS AND WHAT DO THEY WANT
TO LEARN ABOUT AND WHERE SHOULD
WE FOCUS THESE INITIAL TRAININGS
AND BASICALLY, THEY'LL ADDRESS
SUBSTANCE USE AND MISUSE AND
SUBSTANCE USE DISORDERS AND
WOMEN AND AGAIN PROMOTE
DIVERSITY IN SUBSTANCE USE
RESEARCH AND WITH THIS ON-LINE
SYSTEM LEVERAGING EXISTING
TRAINING RESOURCES IN THE
SUBSTANCE ABUSE MENTAL HEALTH
AREA FOR FOR A ASYNCHRONOUS LEARNING.
I JUST WANTED TO DESCRIBE WHAT
ECHO IS AND HOW WE'RE ADAPTING
IT.
EXTENSION FOR COMMUNITY
HEALTHCARE OUTCOMES FOUNDED AT
THE UNIVERSITY OF NEW MEXICO, IT
WAS STARTED AS A WAY TO TREAT
HEPATITIS C PATIENTS WHO WERE
RURAL AREAS WHERE THERE WERE NO
HEPATOLOGISTS OR EXPERTS AND SO
INSTEAD OF TRYING TO DEVELOP
EXPERTISE IN EVERY SITE THEY
USED TELEHEALTH THAT WAS
CENTRALLY LOCATE LOCATED TO SUPPORT
PRIMARY CARE PROVIDERS IN RURAL
AREAS WHO WERE TREATING HELP C
AND THEY DO THIS THROUGH REGULAR
MEETINGS.
IT STARTS WITH I DO DAKA DIE DAKAL TICKS D IDACTICS AND IN OUR
CASE, WE'RE GOING TO DO IS START
BY HAVING A DIDACTIC SESSION AND
WE'LL HAVE MORE THAN ONE EXPERTS
THERE AND WE'LL ASK A SCHOLAR TO
HAVE A QUESTION AND THERE'S SOME
SPECIFIC AREA AND WHAT IS THE
BEST FOR XY AND Z AND WE'LL HAVE
DISCUSSION BY OTHER EXPERTS AND
THE TRAINEES THAT ARE INVOLVED.
ONE OF THE THINGS WE LIKE ABOUT
WHICH WILL BE SO DRY AND SO EASY
FOR SORT OF LOSE ATTENTION SO WE
FIND THAT THE ECHO MODEL IS
ACTUALLY VERY HELPFUL FOR
VIRTUAL LEARNING AND IF I HAVE
THE NEXT SLIDE.
WHEN I TALKED ABOUT DEVELOP THE
WEBSITE I WANTED TO SHOW WE'VE
GOT A NUMBER, WE HAVE 40 FACULTY
THAT ARE FUNDED RESEARCHERS IN
THE SUBSTANCE USE AREA AND MANY
HAVE BEEN VERY INVOLVED IN A
NUMBER OF TRAINING THEY ARE
LISTED HERE WINDOW SO THERE'S A,
WE HAVE A LECTURE SERIES AND WE
DEVELOPED FOR ANOTHER PROGRAM
THAT IS FOCUSED AND SUBSTANCE
USE RESEARCH AND AMY McCRAE
CLARK HAS BEEN INVOLVED IN
DEVELOPING LECTURES ON RESEARCH
WITH VULNERABLE POPULATIONS AND
WE'RE REALLY LUCKY TO HAVE
CONNIE GILL THE HEAD OF OUR
MATERNAL HEALTH AND BEHAVIORAL
HEALTH AND SHE'S THE AUTHOR OF A
NUMBER OF ON-LINE SERIES ABOUT
PERINATAL SUBSTANCE DISORDER SO
THESE ARE THE RESOURCES THAT WE
HAVE THROUGH OUR FACULTY THAT
WILL MAKE AVAILABLE IN THE
ON-LINE TRAINING AND IF IT'S
LECTURES, WE'LL PROVIDE LINKS
FOR THAT AS APPROPRIATE.
PHASE 2, WILL BE BEGIN IN
OCTOBER TO NOVEMBER OF 2012 AND
THAT WILL BE CONSULTATIONS,
MENTORSHIP, NETWORKING AND THEN
AVAILABILITY OF OUR WOMEN'S
INTEREST GROUPS SO LET ME JUST
START BY SAYING, WE'LL BUILD A
WEBSITE THAT WILL BE UP IN
JANUARY AND IT WILL HAVE ON IT,
THE PROFILES OF ALL OF OUR, AS I
SAID, WE HAVE 40 OR SO FUNDED
RESEARCHERS IN THIS AREA AND
WHAT THEIR AREAS OF EXPERTISE
IS.
IF INDIVIDUALS WANT A ONE-TIME
CONSULTATION, AGAIN, THEY CAN
ARRANGE IT THROUGH THE WEBSITE
IF THAT ONE TIME CONSULTATION
TURNS INTO SOMETHING THAT'S A
LITTLE BIT MORE LONG-TERM
MENTORSHIP THAT'S FINE TOO AND
AS I SAID, WE WOULD SUPPORT
VISITS AND EITHER TO AND WE HAVE
THIS THEY RANGE FROM MOLECULAR
BIOLOGY TO POPULATION HEALTH AND
WE'LL MAKE THE PROFILES
AVAILABLE ON THE WEBSITE.
NEXT SLIDE.
PHASE 3 WILL BE FOCUSED ON
SKILLS DEVELOPMENT.
WE WILL PROVIDE A GRANT REVIEW
SYSTEM AND MOCK STUDY SECTIONS
AND THEN ON-LINE GRANT
RESOURCES.
THERE'S A COUPLE OF REALLY GOOD
COURSES THAT ARE OFFERED AT
DIFFERENT MEETINGS AND A COUPLE
OF BOOKS, WORK BOOKS THAT PEOPLE
GO THROUGH SO WE'LL MAKE IT
AVAILABLE AND IF I COULD HAVE
THE NEXT SLIDE AND I DIDN'T
KNOW, YEAH, SO WOVE WITHIN DOING
THESE GRANT REVIEWS AND THE MOCK
STUDY SECTIONS FOR QUITE A WHILE
FOR SECTOR AND CTSA AND SCHOLARS
WILL PRESS THROUGH THE PROGRAM
WEBSITE AND THEY'LL SUBMIT
INITIALLY AN ABSTRACT JUST SO WE
CAN SEE IF IT LOOKS LIKE THIS IS
APPROPRIATE FOR OUR EXPERTS TO
REVIEW AND IF THEY ARE LOOKING
FOR AN EXTERNAL GRANT REVIEW
THEY WILL SUBMIT A FULL DRAFT OF
THE GRANT AND WE'LL SEND IT OUT
TO REVIEWERS PAYING INSIDE AND
OUTSIDE OF MUSC AND TWO TO THREE
REVIEWERS PER GRANT AND THE
INDIVIDUAL WILL RECEIVE WRITTEN
FEEDBACK WITHIN ONE MONTH.
IF SOMEONE REQUIRES SOMETHING A
LITTLE MORE INTENSIVE, A MOCK
STUDY SECTION THEY CAN SUBMIT A
FULL DRAFT OF THE GRANT EIGHT
WEEKS BEFORE THE DUE DATE AND
WE'LL ASSEMBLE A PANEL OF
EXPERTS THAT WILL ENCLOUD THE
MENTEE, IT WILL BE VIRTUAL BUT
WE'LL HAVE THAT MEETING ONE
MONTH AFTER THE SUBMISSION TO
REVIEW THE GRANT AND THE SCHOLAR
WILL SIT IN ON THE REVIEW SO
THEY'LL LEARN FROM IT AS WELL.
IF I COULD HAVE THE NEXT SLIDE.
THIS IS OUR STEER' COMMITTEE AND
WE HAD THE AND ALSO RUNS THE
9-12 AND JAKE' McKINZIE AND
PEOPLE THAT ARE CONNIE GILL IS
THE BEHAVIORAL HEALTH DIVISION
AND THEN JENNA MCCAULEY WHO IS
AN EXPERT IN WEBSITE AND REMOTE
LEARNING WILL GEAR ALL THAT UP
SO I THINK WITH THAT, IF I COULD
HAVE THE NEXT SLIDE, I AM DONE
AND I'M HAPPY TO ANSWER ANY
QUESTIONS.
>> SO WE HAVE ONE QUESTION AND
IN THE COMMENT IS, I KNOW THIS
IS A NEW RESOURCE BUT I'M NOT A
DRUG ABUSE RESEARCHER AND OVER
THE NEXT SIX TO NINE MONTHS,
WHAT SHOULD I BE LOOKING FOR AS
RESOURCE OZ FOR MY CAREER
DEVELOPMENT.
>> SO, YOU KNOW, AGAIN, I THINK
THEY'LL BE SOME MORE GENERIC
MATERIALS AVAILABLE ON THE
WELCOME BACK SIGHT ABOUT WHAT
ARE GOOD GRANT WRITING SOURCES
AND WHAT ARE RESOURCES THAT ONE
MIGHT USE.
EVEN IF YOU ARE NOT IN THE DRUG
ABUSE AREA, SOME THINGS ABOUT
PERINATAL HEALTH AND PERINATAL
RESEARCH PEOPLE IN THE PERINATAL
PERIOD COULD BE OF INTEREST BUT
BASICALLY THIS IS FUNDED BY THE
NATIONAL INSTITUTE ON DRUG ABUSE
SO IT'S FOCUSED FOR A -- WE
UNDERSTAND THAT NOT ALL BIRCWH
SCHOLARS WILL BE ABLE TO FULLY
UTILIZE ALL THE RESOURCES
BECAUSE THE RESEARCHES ARE
WORKING AT THAT INTERSECTION OF
SEX AND GENDER DIFFERENCES AND
SUBSTANCE USE DISORDERS AND
MENTAL HEALTH AND PROBLEMS THAT
SO WE'LL WORK AT THAT INTER
PACE.
>> THANK YOU, AND IT'S JUST MY
OBSERVATION, HAVING BEEN
INVOLVED THAT THIS WAS BEING
CREATED IS THAT THERE ARE
GENERIC COMPONENTS THAT WILL BE
HELPFUL SO CLEARLY THEY WANT TO
SPEAK FOR Dr. CLAYTON BUT
WE'RE EXCITED FOR THIS
OPPORTUNITY BECAUSE OF THE GREAT
GROUP YOU PULLED TELLING.
>> YES.
>> THERE WILL BE SOME GENERIC
OPPONENTS AND WE'LL TRY TO
UPDATE YOU GUYS IN AN ONGOING
MANNER AS WE STAND THINGS UP ON
THE WEBSITE AND I THINK THE
GRAND WRITING RESOURCES ARE
THOSE I'M THINKING OF MOSTLY
THAT WILL BE VERY GENERIC BUT
THERE'S ON-LINE TRAININGS AND
STUFF THAT WOULD BE USEFUL.
>> GOOD.
>> AND THAT LEADS INTO THE
SECOND QUESTION FROM THIS PART,
THEY'RE WONDERING IN TERMS OF
REMOTE LEARNING, ZOOM, ZOOM
CALLS, SO WOULD SOMETHING LIKE A
GRANT REVIEW, WOULD YOU PLAN ON
CONDUCTING IT OF VIA ZOOM OR NOT
BE IN-PERSON?
>> CAN YOU HAVE A WRITTEN GRANT
REVIEW OR MOCK STUDY SECTION.
THE WRITTEN GRANT WILL BE
COMPLETELY IN WRITING AND
SOMEONE WILL SEND THE GRANT IN
AND THEY WILL GET WRITTEN
COMMENTS BACK.
THE MOCK STUDY SECTION WE WILL
CONDUCT IT OVER ZOOM AND IT WILL
BE A VIRTUAL MOCK STUDY SECTION.
>> ONE OF THE ONLY GOOD THINGS
ABOUT COVID IS IT HAS TAUGHT US
DIFFERENT WAYS OF INTERACTING
AND SO THE NEXT QUESTION S. THE
40 FACULTY THEY'RE MAINLY IN THE
SUBSTANCE ABUSE AREA AND YOU
INDICATED THAT IF SOMEONE DID
WANT TO GRANT REVIEW, AND IT
WASN'T IN SUBSTANCE ABUSE, WOULD
YOU BE ABLE TOLL ACCOMMODATE
THEM OR NO?
>> NO, WE'RE NOT, YOU KNOW, WE
REALLY AREN'T ABLE TO FIGHT --
YOU KNOW, AS YOU CAN IMAGINE,
YOU KNOW THE EXPERTS IN YOUR OWN
FIELD AND I DON'T REALLY KNOW
THE EXPERTS SO I WOULDN'T BE THE
BEST PERSON TO HELP YOU IF THAT
WAS YOUR AREA.
I WOULDN'T BE THE BEST PERSON TO
HELP YOU FIND A REVIEWER BUT IF
YOU HAVE A GRANT IN SUBSTANCE
USE AND OR ANY MENTAL HEALTH
ISSUES RELATED TO SUBSTANCE USE,
PTSD, THAT SORT OF THING, WE
HAVE A CAD RAY OF PEOPLE THAT
CAN REVIEW IT THEMSELVES OR
WE'LL KNOW THE BEST REVIEWERS
SO, IF IT'S OUTSIDE OUR AREA
IT'S BEYOND THE SCOPE.
>> I THINK THOSE ARE THE
QUESTIONS AND I DID WANT TO JUST
CLARIFY FOR THE AUDIENCE AND
THAT I WOULD BE HAPPY TO SERVE
AS A LIAISON WITHIN THE PROGRAM
TO YOU AND YOUR COLLEAGUES SO
THAT YOU ARE NOT INUNDATED AND
WE CAN ARRANGE ONCE WE GET
PASTING MEETING HOW TO ROLL THIS
OUT IN TERMS OF COMMUNICATIONS.
WORKING WITH THE PIs.
SO I WANTED TO THANK YOU VERY
MUCH FOR YOUR LEADERSHIP AND
YOUR DEDICATION AND YOU ARE A
BIRCWH P.I. SO YOU KNOW THE
PROGRAM WELL AND WE APPRECIATE
ALL YOUR EFFORTS IN TERMS OF
RESEARCH.
THANK YOU SO MUCH.
>> THANK YOU, I APPRECIATE IT
AND I REALLY HOPE WE CAN GET
SOME ENTHUSIASM FOR THIS PROGRAM
AND I HOPE YOU WILL ENCOURAGE
LOOK AT THE WEBSITE AND
ENCOURAGE YOUR THE PROGRAM WILL
ONLY BE AS SUCCESSFUL AS THE
INENTHUSIASM OF THE PARTICIPANTS
SO, WE'RE LOOKING FORWARD TO IT.
>> ABSOLUTELY AND ONE LAST NOTE,
YOU YOURSELF ARE THE ROLE MODEL
AND I MEAN WHEN I WAS DOING THIS
THE PREP TO INTRODUCE YOU TO
HAVE THREE INSTITUTES FUNDING
LARGE AWARDS TO YOU IS JUST
AMAZING SO, I MEAN, YOU ARE
CLEARLY A ROLE MODEL FOR ALL OF
US SO THANK YOU AGAIN.
>> THANK YOU, VERY MUCH.
IT WOULD BE NICE TO BE WORKING
WITH YOU AGAIN.
>> TAKE CARE.
>> ALL RIGHT, BYE-BYE.
>> SO, OUR THIRD SESSION IS BACK
TO OUR DIRECTOR Dr. CLAYTON
AND ALL OF US ARE SO EXCITED
ABOUT THIS AND SO I WILL TURN IT
OVER TO JANINE TO BRIEF EVERYONE
ON THIS BRAND NEW
TRANSFORMATIONAL PROJECT.
>> THANK YOU SO MUCH.
LET ME GET MY SCREEN UP.
>> I AM EXCITE TODAY SHARE
INFORMATION WITH YOU ABOUT A NEW
PROGRAM.
A COLLABORATION WITH THE
NATIONAL INSTITUTE OF ARTHRITIS,
MUSCULAR SKELETAL AND SKIN DES
SEIZES AND WE'RE TALKING ABOUT
THIS AS A TEAM LEADING A NEW
TEAM PROGRAM.
THE NAME OF THE PROGRAM IS TEAM
SCIENCE LEADERSHIP TO ADVANCE
WOMEN'S HEALTH WITH A FOCUS ON
AUTOIMMUNITY AND IMMUNE MEDIATED
DISEASES AND ITSEN INTENDED TO
TRAIN SCIENTIST TO LEAD LARGE
PROJECTS, MULTI-PRONGED PROJECTS
WITH MULTIPLE COMPONENTS IT'S
DESIGNED TO BE ANNIE PERCENTING
AND COLLABORATIVE AND HOW
IMPORTANT IT IS TO GET MORE
SCIENCE TO ENABLE THESE WOMEN
SCIENCE LEADERS AND WOMEN TO
BECOME LARGE CON OR SLUM TEAM
LEADERS AND AS CONSORTIUM LEADERSAND IT WA S DELIGHTFUL FOR US TO
HAVE THE NEW DIRECTOR OF NAIMS
SPEAK AT OUR RESENT ADVISORY
COMMITTEE FOR RESEARCH ON
WOMEN'S HEALTH AND SHE INVITED
ME TO SPEAK AT THE NAIMS COUNCIL
ABOUT THIS PROGRAM WHERE WE
LAUNCHED IT TOGETHER.
WE HAVE LONGSTANDING
COLLABORATIONS WITH ORWH AND
NAIMS BECAUSE SO MANY OF THE
GROUPS THAT NAIMS WAS FOCUSED ON
NOW WITH Dr. CRISWELL SO WE'RE
THRILLED TO EXPAND OUR
PARTNERSHIP WITH NAIMS FOR THIS
NEW PROGRAM.
THIS PROGRAM WILL BE LEVERAGING
A LARGE PUBLIC-PRIVATE
PARTNERSHIP CALLED ACCELERATING
MEDICINE PARTNERSHIP.
AND THE ACCELERATING MENNANCES
PIP WAS LAUNCHED IN 2014 IT'S A
PUBLIC-PRIVATE PARTNERSHIP
BETWEEN NIH, THE FOOD AND DRUG
ADMINISTRATION AND LIFE SCIENCE
COMPANIES AND NON PROFITS, AND
OTHER ORGANIZATIONS.
AND IT'S THROUGH THE FOUNDATION
FOR NIH OR FNIH.
THE PARTNERSHIP HAS MULTIPLE
COMPONENTS AND SOME OF THEM ARE
LISTED HERE WITH THESE
MULTI-COLORED ROW HOUSES HERE
AND IT HAS LARGE EFFORTS.
THE ALZHEIMER'S DISEASE EFFORTS,
ONE COMMON METABOLIC DISEASE AND
SCHIZOPHRENIA AND AUTOIMMUNE AND
IMMUNE MEDIATED DISEASES.
THE COMMON GOAL OF INCREASING
DIAGNOSTICS AND THERAPEUTICS FOR
PATIENTS AND REDUCING THE TIME
AND COST OF DEVELOPING THEM.
A COMMON GOAL IS TO IMPROVE
UNDERSTANDING OF THERAPEUTICALLY
RELEVANT BIOLOGIC PATHWAYS AND
VALIDATE INFORMATION THAT CAN BE
RELEVANT FOR MULTIPLE
THERAPEUTICS.
AND JUST TO GIVE A SENSE OF THE
SCALE OF THIS PROGRAM, TO DATE
SINCE 2014, OVER $768 MILLION
HAVE BEEN INVESTED IN THIS
PROGRAM THAT HAS AN INTEGRATED
GOVERNANCE STRUCTURE THAT
ENABLES THE BEST CONTRIBUTION TO
SCIENCE FROM ALL PARTICIPANTS.
SO LET'S DIG DEEPER INTO THE
AUTOIMMUNE AND IMMUNE MEDIATED
DISEASE AMP OR AMP AIM
PARTNERSHIP WITH IS ONE
COMPONENT THAT WE'RE LEVERAGING.
THEY HAVE STRENGTH IN TEAM
SCIENCE AND COLLABORATION THAT
HAVE BEEN WELL DOCUMENTED OVER
THE YEARS AND THAT'S CRITICALLY
IMPORTANT TO HELP US LEADERS AND
DEVELOP LEADERS TO DEAL
EFFECTIVELY WITH THE COMPLEXITY
OF BIG TEAM SCIENCE-BASED
PROJECTS.
THE BIRCWH IS ONE EXAMPLE OF OUR
STRENGTH AT ORWH IN CULTIVATING
LEADERSHIP FOR WOMEN HEALTH
RESEARCHERS INCLUDING WOMEN
SCIENTISTS IN PARTICULAR
SUPPORTING EARLY AND MID CAREER
WHERE THERE'S SO MUCH POTENTIAL
FOR US TO BREAK OUT OF THE BOX
AND DO NEW THINGS.
SO TOGETHER, WE'RE SEEKING TO
TRAIN THE NEW KIND OF LEADER,
ONE WITH WIDER EXPERIENCE AND
UNDERSTANDS THE INTER
RELATIONSHIPS OF ALL THE PLAYERS
IN THE RESEARCH, HEALTH RESEARCH
ECOSYSTEM.
AND WE WANT TO CREATE A CROSS
SECTORAL COLLABORATIVE
EXPERIENCE AND IT WILL ENABLE
LEADERS TO BE LARGE CONSORTIUM
TEAM LEADERS SO THAT'S WHY WE'RE
PLEASED TO ANNOUNCE A NEW AND
EXCITING PROGRAM DESIGNED TO
CREATE A MORE ROBUST KADRI OF
RESEARCHERS DEDICATED TO WOMEN'S WOMEN'S
HEALTH RESEARCH.
THE GOALS OF THE PROGRAM THE
OVER ALL GOAL IS TO EXPAND THIS
KADRI OF WOMEN'S HEALTH SCIENCE
WHO'S CAN LEAD COMPLEX
HIGH-IMPACT RESEARCH PROGRAMS
AND ACADEMIA, EASTBOUND INDUSTRY
AND THE PUBLIC-HEALTH SECTORS.
FIRST, GOAL, IMPROVE WOMEN'S
HEALTH BY SUPPORTING RESEARCH
AND DEVELOPMENT OF THESE WOMEN
HEALTH SCHOLARS WHO SPECIALIZE
IN AREAS RELATED TO AUTOIMMUNITY
AND IMMUNE RELATED DISEASES
WHICH IS SO IMPORTANT FOR
WOMEN'S HEALTH AND RELATED
SCIENTIFIC AND CLINICAL TOPICS.
WE WANT TO PROVIDE THIS PROGRAM
TO DEVELOP THEIR SKILLS SETS IN
TEAM SCIENCE THROUGH THIS
COLLABORATIVE EXPERIENCE AND WE
WANT TO ENHANCE THIS SCHOLARS
LEADERSHIP AND MENTORSHIP
EXPERIENCES BY EXPANDING THEIR
NETWORKS OUTSIDE OF THEIR
CURRENT PLACE OF EMPLOYMENT AND
IN THEIR CURRENT SECTOR SO THEY
CAN SERVE IN TERMS AS FUTURE
EFFECTIVE MENTORS FOR
GENERATIONS OF TEAM SCIENTISTS,
FOCUSED ON IMPROVING WOMEN'S
HEALTH.
WE WANT TO INTEGRATE THESE NEW
EMERGING LEADERS WITH UNIQUE
SCIENTIFIC QUESTIONS ESPECIALLY
THOSE RELEVANT TO WOMEN'S HEALTH
AND SEX DIFFERENCES AND
APPROACHES INCLUDING NEW FIELDS
LIKE DATA SCIENCE ANALYSIS, THAT
CAN LEVERAGE THE AMP AIM
INFRASTRUCTURE AND LEVERAGE THE
SAMPLES THAT EXIST AND THE
COHORTS AND THE ON GOING STUDIES
AND DATA AVAILABLE TO ADVANCE
AND IMPROVE OUTCOMES FOR
AUTOIMMUNE IMMUNE DISEASE AND
OTHER RELEVANT SCIENTIFIC
TOPICS.
WE WANT TO INTEGRATE AND
SYNERGIES THE SCHOLARS' WORK
WITH THE AMP AIM NETWORK
SCIENTIFIC GOALS.
AND THE PROJECTS' DUTY TO
ADDRESS SCIENTIFIC QUESTIONS
THAT ENHANCE THE REACH AND
IMPACT OF AMP-AIM AND WILL
BENEFIT FROM THE INFRASTRUCTURE,
CLINICAL INFORMATION SAMPLE,
SCIENTIFIC EXPERTISE AS WELL AS
AMP-AIM AND BRING A NEW
OPPORTUNITY TO THE AMP-AIM
NETWORK WHICH IS NOT YET COVERED
AND I TALKED ABOUT THIS PROGRAM
AND A BLOG POST EARLIER THIS
YEAR AND WHERE A HIGHLIGHTED THE
FACT THAT MENTORING IS A
CRITICAL COMMUNICATION CHALLENGE
AND THROUGH WHICH WE AS .
MEDICAL RESEARCH COMMUNITY CAN
BOTH GAIN AND UNDERSTANDING OF
THE CHALLENGES FACED BY WOMEN IN
SCIENCE AND -- DESPITE GREAT
PROGRAMS LIKE THE BIRCWH AND
OTHERS, A BIOMEDICAL AND THE
RESEARCH ECOSYSTEM ITSELF, WE
SEE THAT A STUBBORN PROBLEM
PERSISTS, NAMELY WOMEN ENTER THE
ACADEMIC CAREER LADDER AND
DESPITE THEM ENTERING IN ONE
CASE FOR BIOLOGICAL LIFE
SCIENCES AT OVER PARITY BY THE
TIME YOU GET TO LEADERSHIP
POSITIONS WE SEE FOR ALL OF
THESE CAREERS, WHETHER IT'S
CHEMISTRY, MATHEMATICS OR
COMPUTER SCIENCE, THE NUMBERS OF
WOMEN BELOW PARITY AND AT EVERY
LEVEL BEYOND THE DOCTORATE AND
THIS IS A SITUATION THAT EXISTED
FOR MANY YEARS AND IT'S NOT
SIMPLY A PIPELINE ISSUE, AND WE
SEE WHAT IS HAPPENING IN MEDICAL
SCHOOLS NOW OVER HALF OF THE
MEDICAL STUDENTS ARE WOMEN AND
THEY'VE BEEN THERE 40% FOR
DECADES AT THE HOSPITAL C.E.O.
LEVEL WE SEE LOWER RATES AND SO
WE WILL WORK TO DO AND WE WANT
TO GET WOMEN INTO LEADERSHIP IN
EARLIER STAGES AND WE WANT THEM
TO BE PREPARED FOR THE
LEADERSHIP THAT IS NEEDED FOR
SCIENCE TODAY.
WE KNOW THAT WOMEN AND ACADEMIC
MEDICINE CAN CONTINUE TO FACE
SIGNIFICANT SYSTEMIC INEQUITY
AND DO NOT RECEIVE PROMOTIONS OR
ADVANCE TO LEADERSHIP ROLES AT
THE SAME RATE AS MEN.
GENDER DIS PE DISPARITIES AND WOMEN
RECEIVE LOWER SALARY OFFERS AND
LESS INSTITUTIONAL RESEARCH
FUNDING IN SOME CASE AND WE'VE
TALKED ABOUT WORK LIFE BEING
PROGRESSIVE THROUGH OUT MEDICINE
AND SCIENCE GENERALLY AND WOMEN
PHYSICIANS SAFE SIGMA THAN MEN
DO AND GIVING RESPONSIBILITIES
AND THE FACT THAT WE SEE
CONTINUING CHALLENGES WITH
SEXUAL HARASSMENT AND HOS PILL
TEE AND DISCRIMINATION IN THE
WORKFORCE AND ALL THE WAY TO THE
INSTRUCTOR LEVEL AND I'VE BLOWN
THAT UP FOR YOU HERE ON THE
RIGHT IN TERMS OF WOMEN
DEPARTMENT AND YOU CAN SEE WOMEN
OF COLOR REPRESENT A SMALLER
PREPORTION THAN DO OTHERS AND WE
WANT TO BE ABLE TO ADVANCE ALL
WOMEN IN SCIENCE AND WE HAVE
ARTICULATED IN THE PLAN A VISION
WHERE ALL WOMEN REACH THIS SO WE
STILL HAVE WORK TO DO HERE, WE
HOPE TO BALANCE THE SCALES IN
KEY AREAS WHERE WOMEN IN SCIENCE
CAN CONTINUE TO BE UNDER
REPRESENTED AND ESPECIALLY AT
MID CAREER AND EVEN FOR FIELDS
LIKE COMPUTER SCIENCE AND WHERE
COMPUTER SCIENCE MAJORS AT THE
UNDERGRADUATE LEVEL HAD BEEN
INCREASING FOR MANY YEARS AND
THEY ARE NOW DECREASEING AND WE
DO HAVE WORK TO DO.
IN TERMS OF DATA WITH GENDER AND
RO1 EQUIVALENT GRANTS AND
SUCCESS RATES, AND YOU CAN SEE
WOMEN AND MEN HAVE SIMILAR
SUCCESS RATES.
TYPE 2, THERE ARE DIFFERENCES
OVER THE YEARS WITH WOMEN BEING
LESS SUCCESSFUL FOR TYPE 2s
AND IN THE RECENT YEARS, WOMEN
AND MEN ARE SIMILARLY SUCCESSFUL
WHEN THEY APPLY.
IF YOU LOCK AT THIS DATA, WOMEN,
HELP, THESE ARE COMPETING
APPLICATIONS HERE AND HERE ARE
THE NUMBERS OF APPLICATIONS FOR
WOMEN AND FOR THE LAST TWO YEARS
AND HERE ARE THE NUMBERS OF
APPLICATIONS FOR MEN.
BECAUSE THERE ARE FEWER WOMEN IN
THE POOL, THAT'S ONE PIECE OF
IT.
ALTHOUGH BOTH WOMEN AND MEN HAVE
A 20% SUCCESS RATE IN COMPETING
RPGs, THIS IS A CHALLENGE FOR
US.
BUT WHAT ABOUT THE PRECURSOR TO
MANY RPGs.
OVER THE PAST YEARS, THIS DATA
IS FROM OUR BY ANNUAL REPORT THE
REPORT OF THE ADVISORY COMMITTEE
ON RESEARCH OF WOMEN'S HEALTH
AND THE FY19-20 REPORT INCLUDES
VERY DETAILED DISAGGREGATED DATA
BY SEX GENERATION AND ETHNICITY
AND FOR NIH AND ALSO OUR NIH
EMPLOYEES WHO ARE SCIENTISTS AND
YOU CAN SEE FOR AWARDS FROM 2016
TO 2020, WE SEE THAT THIS IS THE
PERCENTAGE OF WOMEN AND IT IS
OVER 50% OR 50% NEARLY 50% FOR
ALL OF THESE LEVELS AND SO WOMEN
ARE COMPETING SUCCESSFULLY AND
GETTING K AWARDS AND WE'RE NOT
SEEING THAT TRANSLATING INTO
FURTHER DOWN THE PIPELINE.
SO THAT PIPELINE ANALOGY THAT
YOU'VE HEARD SO OFTEN, REALLY
DOES NOT APPLY TO WHAT WE SEE IN
SCIENCE TODAY.
EARLIER THIS YEAR, AT THE VIVIAN
PIN SYMPOSIUM WE TALKED ABOUT
THE FACT THAT THE CAREER
LANDSCAPE HAS CHANGED PROFOUNDLY
AND WE INTRODUCED A NEW METAPHOR
AND THAT'S A BRAIDED RIVER AS A
NEW METAPHOR FOR CAREER PATHS.
WE RECOGNIZED THAT INDIVIDUALS
MOVE IN AND OUT OF ROLES IN
SCIENCE AND POSITIONS AND STEM
AND THEY HAVE FULL THEY HAVE
FULL TIME CAREGIVING
RESPONSIBILITIES THAT REPRESENT
THE CATEGORY 6 RAPIDS THAT Dr.
HARTMANN TALKED ABOUT AND THEY
EXPERIENCE ILLNESSES THEMSELVES
AND THEY'RE CARRYING FOR MANY
OTHERS IN THEIR FAMILIES AND WE
SAW THAT DURING COVID AND THAT
THAT ISSUE JUST RAMPED UP.
THESE EXPERIENCES, WHERE WOMEN
AND MEN MOVE IN AND OUT OF PATHS
TRIBUTARIES AND CREEKS, AND CAN
ENTER THE CAREER SPACE FROM A
VARIETY OF VENUES IS A MORE
APPROPRIATE META FOR TO BE
TODAY'S SCIENTISTS.
WE KNOW THAT BENEATH THIS
BRAIDED RIVER, A FOUNDATION OF
MENTORSHIP AND HOLISTIC SUPPORT
IS NEEDED FOR ALL TO SUCCEED AND
WE KNOW THAT IN OTHER
DISCIPLINES CAN STRENGTHEN US,
WE CAN SEE THESE CLOUDS HERE,
I'M GOING TO HAVE TO ADD SOME
RAPIDS TO OUR PICTURE HERE AND
HONOR Dr. HARTMANN'S AMAZING
PRESENTATION, AND WE ALSO KNOW
THAT THOSE WHO EXPERIENCE RAPIDS
AND Dr. HARTMANN, TALKED ABOUT
US ALL RECOGNIZING THAT WE CAN
ROADWAYS TO THESE CHALLENGES AND
THAT DOES DOES PROMOTE
RESILIENCE AND I DID HAVE A BLOG
AS A MU NET A FOR FORAY CAREER
PATH AND WHAT WE NEED TO DO TO
SUPPORT SCIENTISTS WITHOUT THAT
BRAIDED RIVER AND TO PROMOTE
EQUITY SO THIS NEW LEADERSHIP
SCHOLAR AS A AMP AIM AND TO
CREATE AND TO SUPPORT THE
DEVELOPMENT OF SCIENTIST AND
LEADERS LIKE THOSE FEATURED HERE
AND YOU HEARD OUR LEGACY FOR
LEADERSHIP SPEAKER TODAY AND YOU
MAY NOT KNOW ABOUT Dr.
COURTNEY SILVERTHORNE, SHE'S THE
DIRECTOR OF AIM PROGRAM THAT I
OUTLINED FOR YOU.
SO SHE'S ASSOCIATE V.P. FOR
RESEARCH PARTNERSHIPS AT FNIH
AND PARTNERSHIPS AT NIST AND
Dr. LITA PROCTOR FROM THE
MICROBIOME PROJECT FROM NSF AND
A MARINE, DIRECTOR OF THE MARINE
MICROBIOLOGY WITH THE GORDON AND
BETTY MORE FOUNDATION AND THESE
ARE LARGE INITIATIVES THAT WE
ARE EXAMPLES OF THE KINDS OF
ACTIVITIES THAT ARE REQUIRED FOR
LEADERS OF TODAY AND SO THESE
ARE THE TYPES OF LEADERS THAT WE
SEEK TO SUPPORT AND GROW.
WITH THIS PENULTIMATE SLIDE, I'M
HIGHLIGHTING DATA AND
INFORMATION FROM A RECENT
PUBLICATION THAT I HAD THE
PRIVILEGE OF CO-AUTHORING AND
WITH Dr. MARINE BERNARD, THE
CHIEF OFFICER FOR SCIENTIFIC
WORKFORCE DIVERSITY AT NIH AND
THE NIH ACTING CHIEF-OF-STAFF
AND IS NOW AT OSDP IN THE WHITE
HOUSE AND Dr. KELLY TENHAGGEN
A LEAD FRESH THE SPACE FROM THE
A -- IT HIGHLIGHTS THE
IMPORTANCE OF COORDINATED
EFFORTS AMONG FIVE DIFFERENT
DOMAINS TO ADVANCE WOMEN AND BIO
MEDICAL CAREERS AND WE TALKED
ABOUT THE IMPORTANCE OF ENHANCED
FLEXIBILITY OPTIONS.
AND ONE EXAMPLE BEING OUR
REINTEGRATION PROGRAMS AND
ANOTHER CONTINUITY SUPPLEMENTS A
PROGRAM THEY HELPED TO SPEAR
THROUGH THE NIH WORKING GROUP ON
WOMEN AND BIOMEDICAL CAREER
WHICH I CO-CHAIR WITH THE
DIRECTOR AND THESE CONTINUITIES
SUPPLEMENTS HAVE FUNDING FORAY
WARDIES AND FIRST TIME RPG
RECIPIENTS EXPERIENCING
QUALIFYING THE LIFE EVENT LICK A
CRITICAL ILLNESS OF A CHILD,
LIKE A CRITICAL ILLNESS OF A
PARTNER, AND THEY PROVIDE
FUNDING TO SUPPORT THE RESEARCH
TO CONTINUE DURING THAT
EXPERIENCE SO IF YOU DON'T KNOW
ABOUT THOSE, I ENCOURAGE YOU TO
TAKE A LOOK AT THOSE NEW
SUPPLEMENT THAT'S HAVE BEEN MADE
AVAILABLE IN THE LAST FEW YEARS.
CULTURAL OF INCLUSION IS EQUALLY
IMPORTANT.
AND SO, UNITE IS NIH'S EFFORT TO
ADDRESS THE CONSEQUENCES OF
STRUCTURAL RACISM AND ON THE
BIOMEDICAL WORKFORCE AND THE
PRIVILEGE OF SERVING ON THE END
MIGHTN'T OF THE UNITE EFFORTS SO
A WIDE ARRAY OF INFORMATION ARE
AVAILABLE ON STEPS NIH IS TAKING
INTERNALLY AND TO SUPPORT
ADDITIONAL HEALTH DISPARITIES
RESEARCH TO ADVANCE HEALTH
EQUITY.
DEMONSTRABLE LEADERSHIP IS
CRITICAL AND WHEN FRANCIS
COLLINS ANNOUNCED HE WOULD NOT
BE WILLING TO SPEAK ON HIM POSE
YUM THAT WAS A SIGNAL THAT HE
CHALLENGED OTHERS TO DO THE
SAME.
IT'S THE WAY CULTER CHANGE HAS
SHIFTED SO HERE ARE THE EXAMPLES
OF THE STEPS WE'VE TAKEN IN
TERMS OF HOW REQUIRING CODES OF
CONDUCT FOR NIH SPONSORED
CONFERENCE THAT'S TALK ABOUT THE
IMPORTANCE OF A SAFE ENVIRONMENT
AND WHAT NEEDS TO HAPPEN IF AN
ENVIRONMENT IS NOT SAFE.
STANDARDS FOR SAFE WORK
ENVIRONMENTS BEG PART OF NIH
AWARDS AND EXPLICIT CONDITIONS
OF NIH AWARDS AND NEW
REQUIREMENTS FOR REPORTING
HARASSMENT AND WE NEED THE DATA.
WE NEED TO STUDY INTERVENTIONS
SO WE KNOW WHAT WORKS AND WITH
THE SAME RIGOR WE STUDY ANY
RESEARCH QUESTION AND WE NEED TO
MAKE THAT INFORMATION AVAILABLE
SO THEY'RE LEASHED IN BEST
PRACTICES CAN BE APPLIED AS
APPROPRIATE AND THE RFA THAT
RESULTED FROM THE WORKING GROUP
GENERATED A LARGE AMOUNT OF
INFORMATION AND EVIDENCE THAT IS
NOW BEING PUT INTO PLACE AND
RECENTLY OUR CHALLENGE ON GENDER
ADVANCING INCLUSIVE EXCELLENCE
AND HIGHLIGHTED INSTITUTIONS WHO
WERE DOING WELL.
SO IF YOU HAVEN'T SEEN THIS, I
COMMAND YOU TO TAKE A LOOK AT
THE PAPER AND THIS IS MY LAST
SLIDE.
WE'RE COMMIT TODAY ACHIEVING
EQUITY AND INCLUSION, CONTINUED
EFFORTS ARE NEEDED TO ACHIEVE
EQUITY AND INCLUSION AND
ESPECIALLY GIVEN THE PANDEMIC'S
IMPACT ON WOMEN AND INCLUSIVE
RESEARCH ENVIRONMENT IS JUST AS
IMPORTANT AS HAVING THE
NECESSITY EQUIPMENT TO DO YOUR
RESEARCH.
AND WE AT NIH ARE COMMITTED TO
ACHIEVING GENDER EQUITY ACROSS
THE RESEARCH ENTERPRISE AND WE
KNOW A DIVERSE WORKFORCE
PRODUCES BETTER SCIENCE AND
INNOVATION BUT WE CANNOT DO IT
LOAN, THIS REQUIRES SYSTEM WIDE
AND INSTITUTIONAL WIDE SOLUTIONS
AND CREATIVITY AND
ACCOUNTABILITY.
AND WE LOOK FORWARD TO
INFLUENCING THE WHOLE HEALTH
ECOSYSTEM AND PARTNERING WITH
WHAT MAY BE CALLED
NONTRADITIONAL SECTORS TO
STRENGTHEN AND ROW GENERATE THE
WHOLE ECOSYSTEM FOR WHAT WE NEED
TODAY.
THANK YOU SO MUCH.
BACK TO YOU, Dr. BEGG.
>> Dr. CLAYTON.
THANK YOU, WE'RE A FEW MINUTES
OVER SO WE HAVE A COUPLE QUICK
QUESTIONS.
IS THE TEAM LEADERSHIP PROGRAM
OVER TO PHDs AND MDs?
>> SO Dr. BEGG I BELIEVE THAT
ANSWER IS YES.
>> IT IS YES.
>> AND THEN ANOTHER QUESTION IS
THIS IS FROM A PHYSICIAN, I'M
NOT AN IMMUNOLOGIST BUT CAN I
STILL APPLY?
>> AND I BELIEVE THE ANSWER IS
YES.
THE ISSUE IS NOT THE NECESSARILY
THE FIELD THAT THE PERSON IS
COMING FROM THAT THE RESEARCH
QUESTION CAN BE ANSWERED AND
USING THE AMP-AIM NETWORK AS A
PLATFORM AND THAT IT MEETS THE
OTHER STANDARDS AND CRITERIA FOR
THE PROGRAM.
>> YES AND THERE'S ALSO BROAD
AREAS SUCH AS PAIN AND FATIGUE
AND OTHER THINGS THAT ACTUALLY
ARE ALSO PART OF THE AMP-AIM AND
OUR LAST QUESTION IS, SEX
DIFFERENCES PLAY A ROLE IN HOW
CELLS AND TISSUES INTERACT BIO
MATERIALS USED IN TECHNOLOGIES
THAT ARE TYPICAL OF MUSS CUE
CALORIE SEARCH.
IT RO1, PO1, ET CETERA, TYPE
GRANTS OR ONLY FOR K AWARDS?
AMP-AIM IS PART OF AMP SO IT'S
TOTALLY DISTINCT FROM RO1s AND
POs 1 AND IT TAKES ADVANTAGE
OF OUR ABILITY TO PARTNER BREDLY
ACROSS SECTORS THROUGH FMIH WITH
PHARMA AND NON PROFITS SO IT'S A
COMPLIMENT AND IT'S A
TEAM-SCIENCE ENVIRONMENT.
EVERYTHING IN AMP IS DONE
THROUGH A SHARED GOVERNANCE
STRUCTURE, WITH A TEAM SCIENCE
APPROACH.
AND SO I WOULD ENCOURAGE YOU TO
TAKE A LOOK AT THE WEBSITE AND
WE CAN SHARE THAT INFORMATION
WITH YOU LATER TO GIVE A LITTLE
BIT OF A WINDOW INTO SOME OF THE
AMAZING SCIENCE THAT HAS BEEN
SUPPORTED THROUGH THE AMP
PROGRAM.
I'M JUST ADD THAT DATA SCIENCE,
DATA SCIENTISTS, COMPUTATIONAL
BIOLOGISTS ARE REALLY ENCOURAGED
TO APPLY AND WE REALLY WANT TO
SEE MORE WOMEN IN THOSE FIELDS
AND THIS IS AN OPPORTUNITY AND
WE'RE ACTUALLY GETTING MORE
PARTNERSHIPS, THE OFFICE OF DATA
SCIENCE CENTRAL GEE IS NOW
JOINED US IN PARTNERSHIP FOR
THOUGH PROGRAM WITH NAIMS.
>> I'M WILLING TO BE THE LIAISON
FOR ANYONE IN THE AUDIENCE IF
YOU HAVE FURTHER QUESTIONS AND
FEEL FREE TO E-MAIL ME BECAUSE
I'M WORKING WITH IS NOT AND WITH
THAT WE'LL CLOSE OUT AND WE HAVE
LAST SLIDE TO TAKE US TO LUNCH
AND IT HAS TO BE A QUICK LUNCH,
BECAUSE WE ARE ASKING YOU TO
RETURN 12:30 AND THERE WILL BE A
FIVE MINUTE ALERT AT 12:25 AND
SO PLEASE, REJOIN US IN 20
MINUTES AND FOR THE REMAINDER OF
THE PROGRAM.
GOOD AFTERNOON, EVERYONE, THIS
IS LISA BEGG, WE'RE STARTING OUR
POST LUNCH BREAK SESSION AND
WITH THE PODIUM SESSION FOR
THOSE OF YOU THAT MAY NOT BE
FAMILIAR, THE SCHOLARS THAT
SUBMIT ABSTRACTS COMPETE FOR
APPROVAL TO BE INCLUDED AND
THEY'RE ALSO THE ONES THAT ARE
ACCEPTED ALSO INCLUDED IN THE
JOURNAL OF WOMEN'S HEALTH AND A
SPECIAL ISSUE IN THE FALL SO
THAT IS AVAILABLE, THE LINK
VIRTUALLY IS AVAILABLE IT WOULD
BE BETTER TO HAVE ALL THREE
BIRCWH PODIUM SPEAKERS TAPED
TOGETHER AND THEY'RE INTRODUCED
BY THE P.I. OF THEIR PROGRAM SO
YOU HAVE A LITTLE BACKGROUND ON
THEM AND SO IT WILL BE 45
MINUTES AND THEN, WE COME BACK
AT THAT TIME FOR A GENERAL Q&A
SO WE ENCOURAGE YOU TO SUBMIT
ANY QUESTIONS THAT YOU HAVE INTO
THE Q&A TAB ON THE VIRTUAL
PLATFORM AND SO THAT WE CAN HAVE
SOME DIALOGUE SO WITH THAT I
WILL ASK FOR THE TAPE TO BEGIN
FOR THE THREE PODIUM SPEAKERS.
>> HI, MY NAME Dr. ABBEY
BERENSON.
IT'S MY GREAT PLEASURE TODAY TO
INTRODUCE DR. PHI Dr. CANTU.
HE RECEIVED A MASTER'S DEGREE
AND DOCTORAL DEGREE AT THE
UNIVERSITY OF TEXAS IN AUSTIN.
FOLLOWING THIS, HE WAS RECRUITED
TO UTMB AND RESEARCH DIRECTOR OF
TWO DIFFERENT PROGRAMS AND THE
HISPANIC ESTABLISHED POPULATION
FOR THE EPIDEMIOLOGIC STUDY OF
THE HE WAS PROMOTED TO ASSISTANT
PROFESSOR IN THE DEPARTMENT OF
INTERNAL MEDICINE DIVISION OF
GERIATRICS.
Dr. CANTU'S RESEARCH FOCUSES
ON CAREGIVING AND SOCIAL
RELATIONSHIPS OF OLDER MEXICAN
AMERICANS.
AS A BIRCWH SCHOLAR, HE WILL
EXAMINE GENDER DIFFERENCES IN
THE CARE OF OLDER ADULTS WITH
DEMENTIA AND EXPLORE PROXY
MEASUREMENTS OF COGNITIVE
DECLINE.
PLEASE JOIN ME IN WELCOMING
Dr. CANTU.
>> THANK YOU FOR JOINING ME
TODAY.
I WILL SHARE WORK ON GENDER
DIFFERENCES AND CARE NETWORKS OF
OLDER ADULTS WITH DEMENTIA.
HERE IS AN OUTLINE TO HELP YOU
KEEP TRACK OF WHERE WORE GOING
IN THIS PRESENTATION.
FIRST, I'M GOING TO SHOW YOU THE
RESEARCH QUESTIONS THAT GUIDE
THIS ANALYSIS AND THEN I'M GOING
TO DESCRIBE THE DATA WE USED AND
SAMPLE CHARACTERISTICS AND THEN
I'M GOING TO DESCRIBE OUR
MEASURES OF CARE AND CARE
NETWORKS FOR OLDER ADULT S WITH
DEMENTIA AND THEN SHOW YOU
RESULTS PREDICTING THE HOURS OF
INFORMAL CARE THAT PEOPLE WITH
DEMENTIA RECEIVE.
THIS ANALYSIS IS GUIDED BY THREE
RESEARCH QUESTIONS.
FIRST, WE WANT TO KNOW IF THERE
ARE DIFFERENCE THIS IS THE
COMPOSITION OF CARE NETWORKS BY
FENDER WITH PEOPLE WITH
DEMENTIA.
WHO DOES THE CARING AND ARE THEY
BEING PAID?
SECOND, WE WANT TOE KNOW HOW DO
THE COST OF INFORMAL CARE DIFFER
BY GENDER AND NOT JUST IN TERMS
OF DOLLAR AMOUNT BUT HOURS OF
CARE THAT INFORMAL CAREGIVERS
ARE GIVING AND THE AVAILABLE
ABILITY OF FAMILY CAREGIVERS,
SPOUSES AND CHILDREN, EXPLAIN
THE DIFFERENCES IN HOURS OF
INFORMAL CARE.
AND TO ANSWER THESE QUESTIONS,
WE'RE GOING TO IDENTIFY CASES OF
DEMENTIA IN A NATIONALLY
REPRESENTATIVE DATASET AND WE
WILL CATEGORIZE THE CARE OF
CAREGIVING NETWORKS OF PEOPLE
WITH DEMENTIA AND STRAT GUY THE
HOURS OF CARE BY GENDER AND THEN
WE USE REGRESSION MODELS TO
IDENTIFY GENDER PATTERNS AND
INFORMAL CARE HOURS.
THE DATA WE USE FOR THIS STUDY
COMES FROM THE HEALTH AND
RETIREMENT SURVEY.
AND NATIONALLY REPRESENTATIVE
SAMPLE OF U.S. ADULTS OVER AGE
50 COLLECTED BY ANNUALLY AND WE
USED DATA FROM 2002 TO 2018 AND
WE USED THE CORE INTE INTERNET -- IT
IDENTIFIES DEMENTIA AS A
FUNCTION OF AGE, EDUCATION,
GENDER, DISABILITY, CURRENT AND
PREVIOUS COGNITIVE FUNCTION.
AND IT DOES NOT HAVE A DIAGNOSIS
OF DEMENTIA INSTEAD, THERE ARE A
BATTERY OF COGNITIVE TESTS TO
IDENTIFY THE PROBABILITY OF
DEMENTIA AND RANGE INTERESTING
0.01 TO .99.
ANYBODY WHO HAS IDENTIFIED AS
HAVING A PROBABILITY ABOVE .51
IS PUT INTO OUR SAMPLE AS
PROBABLE DEMENTIA.
AND WE ASKED QUESTIONS ABOUT
CAREGIVING NETWORKS AND THEY
COLLECT A WIDE RANGE OF
DEMOGRAPHIC FAMILY,
SOCIOECONOMIC AND HEALTH
CHARACTERISTICS INCLUDING,
DEPENDGENDER, RACE, NON HISPANIC
WHITE, BLACK AND HISPANIC.
FAMILY CHARACTERISTICS INCLUDED
WHETHER OR NOT SOMEONE IS
MARRIED, THE NUMBER OF LIVING
CHILDREN AND ROW CODE LIVING
CHILDREN INTO THREE MEANINGFUL
CATEGORIES.
THOSE WERE NO CHILDREN, THOSE
WHO HAVE 1-3 CHILDREN AND THOSE
WHO HAVE FOUR OR MORE CHILDREN.
SOCIOECONOMIC STATUS IS MEASURED
BY EDUCATION, COMPARING THOSE
WITH LESS THAN HIGH SCHOOL
EDUCATION, TO THOSE WITH HIGH
SCHOOL EDUCATION OR MORE.
HEALTH IS OPERATIONALIZED INTO
TWO BROAD DOMAINS, DISABILITY,
MEASURED WITH INSTRUMENTAL
ACTIVITIES OF DAILY LIVING AND
ACTIVITIES OF DAILY LIVING
DISABILITY AS A COUNT OF
DISABLING CONDITIONS FROM ZERO
TO 11 AND CHRONIC CONDITIONS
INCLUDE, DIABETES, HYPERTENSION,
STROKE, HEART ATTACK, ARTHRITIS,
CANCER, LUNG DISEASE AND
DEPRESSION.
YOU CAN SEE ACROSS ALMOST EVERY
SAMPLE CHARACTERISTICS THERE ARE
SIGNIFICANT DIFFERENCES BETWEEN
MEN AND WOMEN WITH DEMENTIA.
WOMEN WERE OLDER, THEY WERE
DISPROPORTIONATELY MINORITIES,
THEY WERE LESS LIKELY TO BE
MARRIED, AND THEY HAD MORE
DISABILITIES, AND THEY HAD FEWER
LIVING CHILDREN COMPARED TO MEN
WITH DEMENTIA.
ACTIVITIES DAILY LIVING
DISABILITIES ARE DISABLING
RELATED TO SELF-CARE SO THINGS
YOU NEED TO DO TO MAINTAIN
INDEPENDENCE SUCH AGO WALKING,
DRESSING, BATHING, EATING,
GETTING IN AND OUT OF BED AND
USING THE TOILET.
INSTRUMENTAL DAILY ARE RELATED
TO MAINTAINING A INDEPENDENT
HOUSEHOLD SO THINGS YOU NEED TO
DO AND IN ORDER TO LIVE BY
YOURSELF SUCH AS CLEANING,
PREPARING MEALS, BUYING
GROCERIES, USING A PHONE, TAKING
MEDICATIONS AND MANAGING MONEY
SO THEY DETERMINE IF AN OLDER
ADULT IS EXPERIENCING THESE
DISABLING CONDITIONS AND THEY
ASK WHO IS MOST RESPONSIBLE FOR
HELPING WITH THESE CONDITIONS.
UP TO EIGHT HELPERS COULD BE
NAMED AND WE CATEGORIZED THOSE
HELPERS INTO TWO BROAD
CATEGORIES, INFORMAL CAREGIVERS,
THOSE UNPAID, AND PAID FORMAL
CAREGIVERS AND INFORMAL
CAREGIVERS ARE FURTHER
SUBDIVIDED INTO SPOUSES,
CHILDREN AND OTHER UNPAID FAMILY
AND NON FAMILY MEMBERS.
FORMAL CAREGIVERS, ARE FURTHER
SUBDIVIDED INTO THOSE WHO ARE
PAID NON FAMILY MEMBERS, THOSE
WHO ARE PAID FAMILY MEMBERS, AND
CAREGIVERS WHO ARE PAID BY
INSURANCE.
HERE WE SEE THERE ARE BIG
DIFFERENCES IN THE COMPOSITION
OF CAREGIVING NETWORKS FOR
PEOPLE WITH DEMENTIA BY GENDER.
WOMEN WITH DEMENTIA WERE MORE
LIKELY TO RECEIVE CARE AND
WOMEN'S CARE CAME FROM THEIR
CHILDREN AND OLDER MEN'S CARE
CAME MOSTLY FROM THEIR SPOUSES.
I THINK IT'S IMPORTANT TO NOTE
THAT WOMEN RECEIVE MORE CARE
FROM EVERY SOURCE EXCEPT FOR
SPOUSES.
WE WERE ALSO INTERESTED IN WHAT
WERE THE COST OF CAREGIVING AND
IN TERMS OF HOURS OF CARE
DELIVERED BY EACH SOURCE OF CARE
AND EACH COURSE WAS ASKED ON
AVERAGE, HOW MANY HOURS OF CARE
THEY DELIVERED ON AN AVERAGE
DAY.
AND HERE WE SEE THERE ARE BIG
GENDER DIFFERENCES IN THE
ESTIMATED COST OF INFORMAL CARE
FOR PEOPLE WITH DEMENTIA AND
WOMEN RECEIVED ON AVERAGE, 10%
CARE HOURS THAN MEN AND THOSE
HOURS OF CARE WERE FROM THEIR
CHILDREN.
AND WHILE FOR MEN, MOST OF THEIR
HOURS OF CARE WERE COMING FROM
THEIR SPOUSES.
USING THE REPLACEMENT COST
APPROACH THE NEARLY 20 HOURS OF
CARE EACH WEEK THAT WOMEN
RECEIVE REFLECTED A COST OF
NEARLY $25,000 COMPARED TO
$21,000 A YEAR FOR MEN AND
HOWEVER, IT'S IMPORTANT TO NOTE
THAT IF YOU WERE TO GO OUT AND
ACTUALLY TRY TO PURCHASE CARE
THAT WOULD BE COMPARABLE IN
TERMS OF IN-HOME CARE FOR OLDER
ADULT S WITH DEMENTIA IT COULD
BE MUCH MORE THAN THE $24 PER
HOUR THAT WE ESTIMATED.
AND WOULD DID THIS USING A
TWO-PART REGRESSION MODEL.
WE MODELED THE TOTAL HOURS OF
INFORMAL CARE AS OUR DEPENDENT
VARIABLE IN THIS TWO PART
REGRESSION.
BECAUSE SO MANY PEOPLE WEREN'T
RECEIVING CARE AT ALL, WE FIRST
USED LOGISTIC PROGRESSION TO
PREDICT THE ODDS OF RECEIVING
CARE AND WE USED A GENERALIZED
LINEAR MODEL WITH A LOG LINK
DISTRIBUTION TO PREDICT TOTAL
HOURS OF INFORMAL CARE DEPENDING
ON RECEIVING CARE.
WE CONTROL FOR THOSE INDIVIDUALS
WHO DO NOT RECEIVE CARE IN OUR
MODEL.
IN THE FIRST PART OF OUR
TWO-PART REGRESSION THE ODDS OF
RECEIVING INFORMAL CARE AND AS
YOU CAN SEE HERE, WOMEN WERE
MORE LIKELY TO RECEIVE CARE THAN
MEN AND WHEN WE STRATIFIED THE
MODELS BY GENDER, THEY DON'T
APPEAR TO BE DIFFERENCES IN THE
RELATIONSHIP BETWEEN THE CO VAR
VARIANTS THAT WERE PREDICTING
THE ODDS OF INFORMAL CARE.
THE PREDICTORS OF INFORMAL CARE
WERE THE SAME FOR MEN AND WOMEN
AND WOMEN WERE JUST MORE LIKELY
TO RECEIVE INFORMAL CARE THAN
MEN.
LOOKING AT THE HOURS OF INFORMAL
CARE THERE WERE NO DIFFERENCES
IN THE PREDICTORS OF INFORMAL
CARE BY GENDER.
AND WOMEN RECEIVED MORE WHOA
PREDICTED HOURS OF INFORMAL CARE
AND UNMARRIED AND WHILE WOMEN
RECEIVED MORE CARE THAN MEN,
BETWEEN HOURS OF CARE AND BY
GENDER AND MARITAL STATUS.
IT DID NOT DIFFER BY GENDER AND
WHILE ALL PEOPLE WITH FEWER
CHILDREN RECEIVED FEWER HOURS OF
INFORMAL CARE, THERE WASN'T A
DIFFERENCE BETWEEN WE KNOW AND
WE SEE NON HISPANIC BLACK WOMEN
RECEIVED THE GREATEST NUMBER OF
INFORMAL CARE HOURS.
THERE ARE IN DEED DIFFERENCES IN
CARE NETWORKS, COMPOSITION BY
GENDER.
WOMEN RECEIVED MORE OF THEIR
CARE FROM THEIR ADULT CHILDREN
WHILE MEN RECEIVED MORE OF THEIR
CARE FROM THEIR SPOUSES AND
THAT'S LARGELY A FUNCTION OF THE
FACT THAT WOMEN ARE MUCH MORE
LIKELY TO BE WIDOWED IN LATE
LIFE THAN MEN ARE TO BE WIDOWERS
AND SECOND, INFORMAL CARE
NETWORKS ARE RESPONSIBLE FOR
MORE HOURS OF CARE FOR WOMEN
THAN FOR MEN AND WOMEN RECEIVED
ABOUT 10% MORE INFORMAL HOURS OF
CARE PER WEEK THAN MEN AND THE
GENDER DIFFERENCE THIS IS HOURS
OF CARE CANNOT BE EXPLAINED BY
HEALTH OR AVAILABILITY OF FAMILY
MEMBERS.
AND THESE RESULTS SUGGEST THAT
DEMENTIA MAY CAUSE GREATER NEED
FOR CARE IN WOMEN AND THAN IN
MEN.
SO, THANK YOU SO MUCH FOR YOUR
ATTENTION AND I WANT TO THANK MY
MENTORS AT UTMB, AS WELL AS MY
CO-AUTHORS AND IF YOU HAVE ANY
QUESTIONS, FILL FREE TO' MEL ME
THANK YOU SO MUCH FOR YOUR TIME.
>> IT'S A DISTINCT HONOR TO
INTRODUCE THE ALL OF US AND IT'S
A CLINICAL RESEARCHER, HE
FOCUSED ON SOURCES OF PREGNANCY
IN AS I CLINICIAN TAKING CARE OF
PREGNANT WOMEN SHE'S POSITIONED
TO DEFINE THIS COURSE IN TAKING
FINDINGS TO IMPROVE DIAGNOSIS
AND EX THEN SHE MOVED TO
PITTSBURG IN MATERNAL MEDICINE
AT THE UNIVERSITY OF PITTSBURGH
HOSPITAL.
SHE IS NOW EXPANDING HER STUDIES
BEYOND THE NINE MONTHS PREGNANCY
TO BETTER UNDERSTANDING OF THE
POSTPARTUM CARE AND RECOVERY
AFTER HYPERTENSIVE DISORDERS
DURING PREGNANCY.
PLEASE JOIN ME IN WELCOMING HER
TO PRESENT HER DAUGHTER.
>>
>> THANK YOU FOR ALLOWING ME TO
PRESENT OUR WORK AND INITIATION
OF ANTI HYPERTENSIVE MEDICATIONS
AND FOLLOWING HOSPITAL DISCHARGE
AND AMONG INDIVIDUALS WITH
HYPERTENSIVE DISORDERS OF
PREGNANCY.
HYPERTENSIVE DISORDERS OF
PREGNANCY INCLUDE
PREGNANCY-ASSOCIATED
HYPERTENSION AS WELL AS CHRONIC
HYPERTENSION WHICH IS PRESENT
BEFORE PREGNANCY.
THE PREVALENCE OF HYPERTENSIVE
DISORDERS OF PREGNANCIES, AMONG
DELIVERY HOSPITALIZATIONS, IS
INCREASING AS SHOWN IN THE
FIGURE HERE.
THE MOST RECENT DATA FROM THE
CDC ESTIMATES THAT HYPERTENSION
COMPLICATES 1/7 DELIVER RE
HOSPITALIZATIONS.
HYPERTENSIVE DISORDERS OF
PREGNANCY ARE COMMON AND CAN
CAUSE SEVERE COMPLICATIONS FOR
PREGNANT PEOPLE AND THERE ARE
LEADING CAUSE OF PREGNANCY
RELATED DEATH IN THE UNITED
STATES AND THEY'RE ALSO THE MOST
COMMON REASON FOR POSTPARTUM
HOSPITAL READMISSION.
DESPITE THIS, THERE ARE LIMITED
RECOMMENDATIONS FOR POSTPARTUM
ANTI HYPERTENSIVE MANAGEMENT
FOLLOWING A HYPERTENSIVE
DISORDER OF PREGNANCY.
THE AMERICAN COLLEGE OF
GYNECOLOGISTS OR ACOG SUGGESTS
THAT TREATMENT SHOULD BE
INITIATED FOR PERSISTENT,
POSTPARTUM BLOOD PRESSURE
GREATING THAN 150/100.
BUT THESE RECOMMENDATIONS DO NOT
ADDRESS THE EXPECTED BLOOD
PRESSURE TRAJECTORIES AFTER
HOSPITAL DISCHARGE.
WHICH IS ONE OF THE LARGEST
CONTRIBUTORS TO HOSPITAL ROW
ADMISSION.
DATA FROM HOME BLOOD PRESSURE
MONITORING PROGRAMS, SUGGEST
THERE'S AN EX EXACERBATION AND
YOU SEE HERE IN THE FIGURE, HOME
BLOOD PRESSURE IN THE FIRST TWO
WEEKS POSTPARTUM, ALONG THE X
AXIS WITH BLOOD PRESSURE ON THE
LEFT AND BLOOD PRESSURE ON THE
RIGHT.
THERE'S AN EX ASKER EVACUATION
OAN EXACERBATION WHENMOST INDIVIDUALS HAVE BEEN
DISCHARGED FROM THE HOSPITAL.
WE KNOW THAT THESE HIGHER BLOOD
PRESSURES INCREASE THE RISK OF
SIGMA TERNAL MORBID TEASE SUCH
AS STROKE, SEE SEIZURE AND OTHER
EVENTS.
BECAUSE OF THIS, ACOG RECOMMEND
BLOOD PRESSURE ASSESSMENT THREE
TO 10 DAYS AFTER DELIVERY AND
AGAIN AT THE TIME OF THE
COMPREHENSIVE POSTPARTUM VISIT.
THE PRIOR STUDIES HAVE
DEMONSTRATED POOR ADHERENCE TO
SCHEDULED VISITS DURING THIS
TIME PERIOD.
WHICH IS LIMITED OUR ABILITY TO
UNDERSTAND BLOOD PRESSURE
PATTERNS AFTER HOSPITAL
DISCHARGE.
REMOTE MONITORING AND MANAGEMENT
PROGRAMS HAVE BEEN SHOWN TO BE
FEASIBLE AND IMPROVE ADHERENCE
TO HYPERTENSIVE CARE IN THIS
PERIOD.
THESE PROGRAMS HAVE GIVEN US THE
ABILITY TO BETTER UNDERSTAND
BLOOD PRESSURE PATTERNS AND RISK
FACTORS FOR POSTPARTUM MORBIDITY
AFTER HOSPITAL DISCHARGE.
THUS IN THIS STUDY, OUR
OBJECTIVES WERE TO FIRST
IDENTIFY RISK FACTORS FOR
INITIATION OF ANTI HYPERTENSIVE
MEDICATION AND FOLLOWING
HOSPITAL DISCHARGE POSTPARTUM
AND CHARACTERIZE ASSOCIATED
OUTCOMES, AND SECOND, TO
INTERROGATE THE INPATIENT
PERFORMANCE OF ACOG GUIDELINES
FOR IDENTIFYING INDIVIDUALS WITH
HYPERTENSIVE MEDICATIONS AND WE
UTILIZED DATA FROM A REMOTE
BLOOD PRESSURE MONITORING
PROGRAM AS PART OF A QUALITY
IMPROVEMENT PROJECT THAT
REPLACES THE THREE TO 10 DAY IN
OFFICE VISIT.
INDIVIDUALS ARE ENROLLED IN THE
NURSING CALL CENTER DRIVEN BLOOD
PRESSURE MANAGEMENT PROGRAM BY
THEIR PRIMARY OBSTETRIC PROVIDER
DURING THEIR HOSPITALIZATION AND
THEY'RE PROMPTED TO TAKE AND
REPORT BLOOD PRESSURE BY TEXT
MESSAGE AFTER HOSPITAL DISCHARGE
AND ALLOWING FOR MEDICATION AND
INITIATION IN REAL-TIME
FOLLOWING STANDARDIZED
PROTOCOLS.
TO BE INCLUDED IN THE PROGRAM,
INDIVIDUALS HAD TO BE ENGLISH
SPEAKING AND HAVE A PHONE THAT
ACCEPT TEXT MESSAGES.
FOR THIS ANALYSIS, WE INCLUDED
DELIVERIES BETWEEN
SEPTEMBER 2019 AND JUNE OF 2021
WITH A DIAGNOSED HYPERTENSIVE
DISORDER DURING THE DELIVERY
ADMISSION.
WE EXCLUDED INDIVIDUALS WHO
REPORTED LESS THAN TWO BLOOD
PRESSURES THROUGH THE PROGRAM
AND OR WHO HAD A KNOWN DIAGNOSIS
OF PRE PREGNANCY HYPERTENSION AS
THEIR BLOOD PRESSURE MANAGEMENT
AND GOALS MAY HAVE BEEN
DIFFERENT POSTPARTUM.
WE COMPARED DEMOGRAPHICS AND
CLINIC OUTCOMES AS DEPICTED
HERE.
SHOWN IN THE MIDDLE, INDIVIDUALS
WHO ARE INITIATED ON ANTI
HYPERTENSIVE MEDICATIONS,
THROUGH OUR REMOTE MONITORING
PROGRAM, AFTER DISCHARGE FROM
THE DELIVERY HOSPITALIZATION,
INDIVIDUALS WHO NEVER REQUIRED
ANTI HYPERTENSIVE MEDICATIONS,
AND THIRD, THOSE WHO WERE
STARTED ON ANTI HYPERTENSIVE
MEDICATIONS DURING THEIR
DELIVERY HYPERTENSION.
WE MODEL ODDS OF EMERGENCY ROOM
VISITS AND POSTPARTUM
READMISSION AND TO COMPARE BLOOD
PRESSURE TRAJECTORIES IN THE
PERIOD WE FIT MIXED EFFECTS LYNN
YEAR REGRESSION MODEL WITH RE
PETEED BLOOD PRESSURE MEASURES.
WE TESTED THE DIFFERENCES
BETWEEN GROUPS USING LIKELIHOOD
RATIO TESTS AND FINALLY REINTEG
GATED THE ABILITY OF THE ACOG
GUIDELINES WITH PERSISTENT
HYPERTENSION AS GREATER THAN
FOUR HOURS APART HAVING A BLOOD
PRESSURE OF MORE THAN 150 OVER
100 AND WHEN A PLIED IN PATIENT
TO IDENTIFY INDIVIDUALS WHO
ULTIMATELY REQUIRED ANTI
HYPERTENSIVE AGENTS.
OVER ALL, THERE WERE 2,705
INDIVIDUALS ENROLLED IN THE
PROGRAM OVER OUR TARGET TIME
PERIOD.
WITH 54% NEVER REQUIRING MEDS
AND 46% REQUIRING ANTI
HYPERTENSIVE MEDICATIONS AND
AMONG THOSE REQUIRING ANTI
HYPERTENSIVE MEDICATIONS, HALF
WERE STARTED ON ORAL MEDICATIONS
DURING THE DELIVER ROW
HOSPITALIZATION SHOWN HERE IN
RED AND ABOUT HALF WERE STARTED
ON MEDICATIONS AFTER HOSPITAL
DISCHARGE.
SHOWN HERE IN ORANGE.
WHEN WE COMPARED DEMOGRAPHIC
CHARACTERISTICS, BETWEEN THOSE
EVENTUALLY NEEDING AGENTS AND TO
THOSE WHO NEVER NEEDED AN HIGH
HYPERTENSIVE MEDICATIONS, WE SEE
THAT INDIVIDUALS WHO REQUIRED
MEDICATIONS WERE HOLDER, HAD A
HIGHER BODY MASS INDEX AND
IDENTIFY AS BLACK RACE.
WHEN WE CAM PAIRED THEM TO THE
GROUP DURING THE DELIVER ROW
HOSPITALIZATION, WE SEE THAT
THEY ACTUALLY LOOK SIMILAR FROM
THE DEMOGRAPHIC STANDPOINT WITH
THE EXCEPTION OF A SLIGHTLY
HIGHER BMI.
WHEN WE LOOK AT CLINICAL
CHARACTERISTICS OF THE GROUP WE
SEE THOSE REQUIRING ANTI
HYPERTENSIVE AFTER DISCHARGE,
LOOK VERY SIMILAR TO THOSE WHO
NEVER REQUIRED MEDICATIONS.
HAVING A SIMILAR POSTPARTUM
LENGTH OF STAY.
I HAVE EXPECTED, INDIVIDUALS WHO
ARE TREATED WITH MEDICATIONS OR
STARTED ON MEDICATIONS
INPATIENTS DURING THE DELIVERY
HOSPITALIZATIONS, CLINICALLY
APPEARED TO HAVE THE MOST SEVERE
DISEASE.
A HIGHER PREPORTION HAVE A
DIAGNOSIS OF PRE-ECLAMPSIA, PRE
TERM BIRTH, AND RECEIVED
MAGNESIUM.
THEY ALSO HAD A LONGER
POSTPARTUM HOSPITAL LENGTH OF
STAY COMPARED TO THOSE ON
HOSPITAL MEDICATIONS AFTER
DISCHARGE.
ALSO NOT SURPRISINGLY, WHEN WE
LOOK AT IN PATIENT POSTPARTUM
BLOOD PRESSURES WHICH ARE SHOWN
HERE BY GROUP WITH SYSTEM I CAN
ON THE LEFT AND THE RIGHT WE SEE
THAT INDIVIDUALS WHO ARE
STARTING ON MEDICATIONS IN
PATIENT, HAD THE HIGHEST MEAN
AND MAXIMUM SYSTEM I CAN AND DIE
STOLL I CAN BLOOD PRESSURE
DURING THEIR POSTPARTUM
HOSPITALIZATION.
SO IN A DIFFERENT WAY, WHEN WE
LOOK AT THE TRAJECTORY OF SIS
STOLL I CAN AND DIASTOLIC BLOOD
PRESSURE WE SEE THAT THE GROUP
IS STARTED ON MEDICATIONS, THAT
OCCURS BETWEEN DAYS FOUR AND
SEVEN POSTPARTUM.
WE THEN LOOKED AT CARE
UTILIZATION AMONG EACH OF THESE
GROUPS.
AGAIN, WE SEE THAT INDIVIDUALS
STARTED ON ANTI HYPERTENSIVE
AGENTS AFTER DISCHARGE, HAD THE
HIGHEST RATE OF EMERGENCY ROOM
VISITS, AND HOSPITAL
READMISSIONS POSTPARTUM.
WHEN COMPARED TO THOSE WERE
STARTED ON MEDICATIONS DURING
THEIR INPATIENT DELIVERY
HOSPITALIZATIONS, WHO AGAIN
CLINICALLY SEEMED TO HAVE THE
MOST SEVERE DISEASE, THEY HAD A
1.7 FOLD INCREASED ODDS OF
EMERGENCY ROOM VISITS AND A 3.3
FOLD INCREASE ODDS OF HOSPITAL
READMISSION.
AND WHILE CARE UTILIZATION IS
INCREASED IN THIS GROUP, WHAT
WE'RE PARTICULARLY INTERESTED IN
IS MATERNAL MORBIDITY AND THE
SURROGATE FOR THAT WE LOOKED AT
PREVALENCE OF SEVERE
HYPERTENSION IN THE POSTPARTUM
PER IDEA ON HOME BLOOD PRESSURE
MONITORING, WHICH SEVERE
HYPERTENSION GREATER THAN OR
EQUAL TO 160/110 HAS BEEN SHOWN
TO INCREASE HEART FAILURE,
SEIZURES AND STROKE AND MULTI
ORGAN FAILURE SUCH AS RENAL
FAILURE AND WE SEE THAT A THIRD
OF THOSE WHO ARE STARTED ON
MEDICATIONS AFTER DISCHARGE, HAD
SEVERE HYPERTENSION AND THEY HAD
A 1.6 FOLD INCREASE ODDS OF
SEVERE HYPERTENSION AND WHEN
COMPARED TO THOSE STARTED ON
MEDICATIONS WHILE IN PATIENT AND
FINALLY WE ASKED THE QUESTION,
IS IT THAT THE 150 OVER 100 CUT
OFF FOR INITIATION OF
MEDICATIONS, IS MISSING THESE
INDIVIDUALS WHO HAD ULTIMATELY
NEEDED MEDICATIONS AND OR WERE
THEY JUST INAPPROPRIATELY
TREATED DURING THEIR DELIVER ROW
HOSPITALIZATIONS AND SO TO DO
THAT, WE LOOKED AT THE
PREPORTION OF INDIVIDUALS WITHIN
EACH GROUP WHO METED 150 OVER
100 CUT OFF WHILE INPAY SHA.
WE FOUND THAT 25% OF THOSE WHO
NEVER NEEDED MEDICATIONS MET THE
CRY TER WHY AND COMPARED TO 37%
OF THOSE WHO ARE INITIATED ON
MEDICATIONS POST HOSPITAL
DISCHARGE AND 75% OF THOSE WHO
STARTED ON MEDICATIONS IN THE
HOSPITAL SUGGESTING THAT THE
MAJORITY OF INDIVIDUALS WHO
NEEDED INITIATIONS OF
MEDICATIONS, AFTER HOSPITAL
DISCHARGE, WERE NOT ACTUALLY
IDENTIFIED BY THE 150/100
CRITERIA WHEN APPLIED INPAY SHA.
SO BASED ON THOSE FINDINGS, WE
ASKED HOW WOULD A LOWER
THRESHOLD CHANGE THE PREPORTION
OF INDIVIDUALS TREATED WITH
ANTI-HYPERTENSIVE ACTS.
25% OF THOSE NEVER NEEDING
MEDICATIONS, MET THE 150/100 CUT
OFF IN THE HOSPITAL AND 56% OF
THOSE WHO REQUIRE MEDICATIONS,
WERE IDENTIFIED BY THE 150/100.
IF WE USED A LOWER CUT OFF LIKE
140/90, WHICH IS USED FOR
INITIATION OF ANTI HYPERTENSIVE
AND NON OBSTETRIC POPULATION WE
SEE WE WOULD CORRECTLY IDENTIFY
84% OF INDIVIDUALS NEEDING
MEDICATIONS DURING THE DELIVERY
HOSPITALIZATIONS AND WE WOULD
POTENTIALLY END UP OVER TREATING
MORE THAN 60% OF THOSE WHO NEVER
ACTUALLY REQUIRED MEDICATION.
WHICH COULD INCREASE THE RISK OF
ADVERSE EFFECTS RELATED TO AN
HIGH HYPERTENSIVE MEDICATIONS.
REINFORCING THAT SIMPLY LOWERING
THE THRESHOLD FOR MEDICATION
INITIATIONS WITHOUT UTILIZATION
OF HOME BLOOD PRESSURE
MONITORING, AND DEVELOPMENT OF
FURTHER TOOLS FOR RISK
STRATIFICATION, WOULD BE
PREMATURE.
THIS IS THE LARGE PROSPECTIVE
COHORT WITH REAL-TIME BLOOD
PRESSURE MEASURES THAT UTILIZE
THE STANDARDIZED MANAGEMENT
PROTOCOLS.
LIKE ANY STUDY, OUR STUDY HAS A
NUMBER OF LIMITATIONS AND THE
SINGLE SITE AS WELL AS IN
PATIENT PROVIDING PRACTICE
DIFFERENCES AND LIMIT THE
GENERALIZABILITY AND HOSPITAL
READMISSION IN RELATION TO
MEDICATION INITIATION.
IN CONCLUSION, OVER 20% OF
INDIVIDUALS IN OUR COHORT
REQUIRED INITIATION OF ANTI
HYPERTENSIVE AFTER HOSPITAL
DISCHARGE AND THESE INDIVIDUALS
HAVE THE HIGHEST HOME BLOOD
PRESSURES AND THE GREATEST ODDS
OF POSTPARTUM HOSPITAL
READMISSION AND CURRENT
GUIDELINES FAILED TO IDENTIFY
THE POSTPARTUM INDIVIDUALS WHO
REQUIRE AN HIGH HYPERTENSIVE
MEDICATION AFTER HOSPITAL
DISCHARGE.
THESE DATA SUPPORT THE CRITICAL
ROLE OF REMOTE BLOOD PRESSURE
MONITORING PROGRAMS AND
HIGHLIGHT THE NEED FOR IMPROVED
TOOLS FOR RISK STRATIFICATION
AND LIBERALIZATION OF THRESHOLDS
FOR MEDICATION INITIATION
POSTPARTUM.
I WANT TO THANK MY CO-AUTHORS
AND MENTORS AND THANK THE BIRCWH
PROGRAM FOR SUPPORTING MY CAREER
AND THIS WORK.
THANK YOU FOR THE OPPORTUNITY TO
PRESENT OUR WORK TODAY.
>> THE BIRCWH SCHOLAR
PRESENTATIONS ARE ALWAYS A
HIGHLIGHT OF THE ANNUAL BIRCWH
MEETING AND PROVIDE A GLIMPSE OF
THE OUTSTANDING WORK THAT'S
BEING CONDUCTED BY BIRCWH
SCHOLARS NATIONWIDE.
I'M TONETTE KROUSEL-WOOD AND
TODAY, I AM DELIGHTED TO
INTRODUCE ONE OF OUR EXCELLENT
SCHOLARS Dr. YILIY YOSHIDA.
SHE RECEIVED HER BACHELOR
DEGREES FROM ALTERNATIVE
MEDICINE FROM CHINESE MEDICINE
AND GLOBAL COMMUNITY HEALTH
SCIENCES FROM THE TULANE
UNIVERSITY SCHOOL OF
PUBLIC-HEALTH AND TROPICAL
MEDICINE AND A PH.D IN COMMUNITY
AND BEHAVIORAL SCIENCES FROM THE
LOUISIANA STATE UNIVERSITY.
AFTER COMPLETING A TWO YEAR
POSTDOCTORAL FELLOWSHIP AT THE
UNIVERSITY OF MISSISSIPPI WITH
THE FOCUS ON CHRONIC DISEASE
EPIDEMIOLOGY, SHE JOINED HER
FIRST FACULTY RANK AT THE
UNIVERSITY OF MISSOURI AT
COLOMBIA AS A RESEARCH ASSISTANT
PROFESSOR.
IN 2019, WE REPLACED A WELCOME
HER TO TULANE UNIVERSITY AS AN
ASSISTANT PROFESSOR IN THE
DEPARTMENT OF MEDICINE AND
SCHOOL OF MEDICINE.
HER CURRENT RESEARCH IS AND
DELINEATING MECHANISMS SHE WAS
ALREADY PUBLISHED 25 PEER REVIEW
JOURNALS INCLUDING 21 AS FIRST
AND SENIOR AUTHORS AND SHE'S
PUBLISHED IN LAST YEAR, SHE
RECEIVED THE YOUNG INVESTIGATORS
AWARD THEY HAVE RECEIVED PILOT
GRANT AWARDS FROM THE LOUISIANA
CENTER FOR CLINICAL AND
TRANSLATIONAL RESEARCH AND THE
MELINDA AND BILL GATES
FOUNDATION.
SHE SERVICE THROUGH SPECIALTY
SEW SIGHS TEASE AS WELL AS
CONDUCTS PEER REVIEW ORWH OVER
20 SCIENTIFIC JOURNALS.
SHE'S PROVEN TO BE AN
OUTSTANDING ACADEMIC CITIZEN,
COL EQUAL, COLLABORATE OR AND
SCIENTIST.
SHE'S EMBRACED THE BIRCWH
MISSION AND HAS CONTRIBUTED
SUBSTANTIALLY TO OUR
UNDERSTANDING OF AND COVID-19.
TODAY SHE WILL PRESENT HER
RESEARCH ENTITLED "PRE DIABETES
AND UNDIAGNOSED AS -- MANY
THANKS TO THE NATIONAL
INSTITUTES OF HEALTH, THE OFFICE
OF RESEARCH AND WOMEN'S HEALTH
AND THE BIRCWH PROGRAM FOR THIS
OPPORTUNITY TO SHOWCASE AND
EXCELLENT WORK AND HER
COMMITMENT TO ADVANCING WOMEN'S
HEALTH.
THANK YOU.
>> HELLO, EVERYONE, I'M A
SCHOLAR AT TULANE UNIVERSITY AND
A IS THE ANT PROFESSOTHANK YOU TO THE NIH OFFICE OF
RESEARCH AND WOMEN'S HEALTH
GIVING THIS GREAT OPPORTUNITY TO
PRESENT THE RESEARCH ON SEX
DIFFERENCES IN DIABETES ASK CARD
YE VASCULAR DISEASE.
I WILL SPECIFICALLY DISCUSS MY
LATEST FINDINGS ON THE
ASSOCIATION BETWEEN PRE DIABETES
AND CARDIOVASCULAR RACE.
I KNOW HOW CONFLICT OF INTEREST
TO DISCLOSE AND THESE OBJECTIVES
OF MY PRESENTATIONS AND FIRST I
WILL BE PROVIDING YOU AN
OVERVIEW OF THE EPIDEMIOLOGY OF
DIABETES WITH A SEX SPECIFIC
PERSPECTIVE AND I WILL SPEND
MORE TIME PROVIDING YOU SOME
MECHANISMS FOR THE SEX
DISPARITIES AND SUCH AS
IMPLICATIONS OF SEX HOR MONTHS
AND MORE SEVERE METABOLIC
PHENOTYPE FOR WOMEN AND MEN AND
PARTICULARLY I WILL COVER THE
ROLE OF PRE DIABETES AND
UNDIAGNOSED DIABETES IN SEX
DISPARITIES.
I WILL ALSO COVER OTHER
BIOLOGICAL RISK FACTORS THAT
POTENTIALLY FURTHER EXPLAIN THIS
SEX DISPARITY.
SO GLOBALLY, THERE ARE MORE MEN
DIAGNOSED WITH DIABETES.
DIABETES PROBLEMS RISES WITH
ADVANCING AGES IN BOTH SEXES.
REACHING THE HIGHEST RATES IN A
VERY OLD WOMAN.
THERE ARE MORE WOMEN DIAGNOSED
WITH PRE DIABETES THAN MEN AFTER
THE GLOBAL SCALE.
IN THE U.S. HE CAN SEE VARIED BY
RACE AND ETHNICITY.
THE PREVALENCE OF DIABETES IS
HIGHER IN WOMEN THAN MEN IN
ALASKA NATIVES AND HISPANICS AND
MEN IN ASIAN AND WHITE GROUPS.
IN NON HISPANIC BLACKS, THE
DIABETES RATE IS ALMOST
EQUIVALENT IN MEN AND WOMEN.
DIABETES IS ASSOCIATED WITH
COMPLICATIONS AND THE MORTALITY
IN DIABETES IS NOT CAUSED BY
DIABETES PER SE BUT RATHER IT'S
DUE TO DIABETIC COMPLICATIONS
AND THE MOST COMMON CAUSE OF
THAT IN THOSE TYPE 1 AND TYPE-2
DIABETES IS CBD.
IT ACCOUNTED FOR HALF IN THE
DIABETES AND NOTABLY, THERE IS A
SEX DISPARITY THAT IS FEMALE
PATIENTS FACE A HIGHER RACE OF
BOTH FATAL AND NON FATAL
SEVERITY COMPARED TO MALE
PATIENTS.
AND THESE ARE THE PROVEN
ANALYSIS FROM 60 COHORTS AROUND
THE WORLD BY THE YEAR OF 2014.
THEY'RE RACE SHOWS THAT DIABETES
CONFERS A 44% GREATER RISK FOR
CHRONIC HEART DISEASE CHD IN 27%
HIGHER RISK OF STROKE IN WOMEN
COMPARED TO MEN AND SO WHAT IS
THE REASONS FOR THIS SEX
DISPARITY IN DIABETICS, THE
MECHANISMS ARE NOT FULLY RISKS.
SOME MAY BE THE RESULT OF
WOMEN'S POOR MANAGEMENT AND
TREATMENT OF RISK FACTORS.
HOWEVER, MANAGEMENT AND
TREATMENT ALONE DO NOT FULLY
EXPLAIN WOMEN'S DISADVANTAGE.
MORE EVIDENCE SUGGESTS THAT
BIOLOGICAL DIFFERENCES BETWEEN
MEN AND WOMEN UNDER PAYING THE
HIGH-RISK OF DIABETES RELATED
CART YO VASCULAR COMPLICATIONS.
AND FOR EXAMPLE, THE IMPLICATION
OF MENOPAUSE TRANSITION, THE USE
OF SEX OR MONTHS AND IN OUR
PREVIOUSLY ANALYSIS BASED ON
OBSERVATIONAL COHORTS, WE FOUND
THAT MENOPAUSE REPRESENTING THE
EARLY LOSS OF ESTROGEN
SIGNIFICANTLY AUGMENT
CARDIOVASCULAR RATES IN WOMEN
WITH PREEXISTING DIABETES.
THEY WE FOUND THE USE OF HORMONE
REPLACEMENT THERAPY, ESPECIALLY
EARLY USE OF THE THERAPY IS
ASSOCIATED WITH THE RISK
REDUCTION OF SEVERITY AND WOMEN
WITH PRE DIABETES AND OR TYPE-2
DIABETES.
MANY ALSO SPECULATE THAT WOMEN
EXPERIENCE A GREATER
DETERIORATION IN RISK FACTORS
COMPARED TO MEN IN THE
TRANSITION FROM NORMAL GLYCEMIA
TO DIABETES AND THIS GRAPH SHOWS
YOU THAT WOMEN NEED TO PUT ON
MORE WEIGHT ESPECIALLY IN THE
ABDOMINAL AREA OR A MORE LIKELY
TO HAVE A DIAGNOSIS OF DIABETES.
AS OPPOSED TO MEN WHO CAN BE
DIAGNOSED WITH DIABETES AS A
LOWER RATE AND NORMAL FAT
DISTRIBUTION.
WOMEN HAVE A STRONGER
ASSOCIATION OF ABDOMINAL FAT.
TO VERIFY IF WOMEN HAVE A SEVERE
METABOLIC RISK PHENOTYPE BEFORE
DIABETES, WE DID A COHORT
ANALYSIS BASED ON THE RISK IN
COMMUNITIES STUDY AND THE ERIC
STUDY AND WE EXAMINED A
CONTINUOUS BIOMARKER, THE
METABOLIC SYNDROME AND WAYS TO
AND BLOOD PRESSURE, HDL AND THE
GLUCOSE.
THE Y AXIS REPRESENTS THE CHANGE
OR THE DETERIORATION RATE OF
METABOLIC SYNDROME SEVERITY AND
THE HIGHER THE NUMBER, THE
GREATER THE DETERIORATION.
LOOK AT GREEN BARS, ESPECIALLY
THE FIRST TWO AND GENERALLY THE
PRE DIABETES FACE WILL MAKE
EXPERIENCE A SIGNIFICANT GREATER
DETERIORATION IN SEVERITY
COMPARED TO MEN.
WHAT ALSO STRIKES IS THAT EVEN
IN THE NORMAL TEST IN THIS NEW
LIFE COHORT AND THESE ORANGE
BARS, THE CHANGE OF THE RISK OR
IS STILL GREATER IN MORE THAN
COMPARED TO MEN SO OUR FINDINGS
SUGGEST THAT IT'S PRE DIABETES,
HAVE ADVERSE METABOLIC RISK
PROFILE WHICH POTENTIALLY PUTS
THEM AT A HIGH-RISK OF SEVERITY
LATER IN LIFE.
SO WE FOUND PRE DIABETES IS A
ASSOCIATE WITH THE WORSE
METABOLIC RISK PROVIDER COMPARED
TO MEN AND WE WONDERED TO WHAT
EXTENT PRE DIABETES HAS THE RISK
OF SEVERITY AND HOW THE MAPPINGS
OF THIS ASSOCIATION VARIES BY
SEX AND SO WOMEN HAVE A HIGHER
PREVALENCE OF UNDIAGNOSED
DIABETES WE WANT THE FACTS OF
DELAYED DIAGNOSIS AND AND THIS
PROLONGED TIME AND ALSO SERVE AS
EXPLANATION AND HIGH-RISK SA
SEVERITY AND TO UNDER THIS
QUESTION WE HAVE ANALYSIS BASED
ON THREE COMMUNE BASED COHORTS
AND THE STUDY AND STUDY AND THE
JACKSON HEART STUDY AND PRE
DIABETES AND UNDIAGNOSED
DIABETES IS ASSOCIATED WITH
GREATER MAGNITUDE OF IN WOMEN
THAN IN MEN AND WE HAVE THREE
SETS OF OUTCOMES INCLUDING HEART
DISEASE, COMPOSED BY MIO CARDIO
INFECTIONS, AND PROCEDURES AND
WE ALSO INCLUDE TWO MAJOR TYPES
OF STROKES AND A COMPOSITE
OUTCOME INCLUDING ANY CONDITION
INVOLVED.
WE DEFINE OUR EXPOSURE PRE
DIABETES BASED ON THE AMERICAN
DIABETES ASSOCIATION CRITERIA
AND THAT IS FASTING GLUCOSE 100
TO 125 AND 5.7 TO 6.4.
WE DEFINE UNDIAGNOSED DIABETES
BY FASTING GLUCOSE LEVEL OVER
126 OR OVER 6.5 WITHOUT A
PREVIOUSLY DIAGNOSIS OF DIABETES
FOR MEDICATION USE AND WE
PERFORMED PROPORTIONAL HAZARD
MODELS ADJUSTED CAREERS LISTED
HERE AND THIS IS OUR EXAMPLES
SELECTION PROCESS.
AFTER EXCLUDING THOSE PROBLEMS,
SEVERE CASES AND THOSE WITH
PREVIOUS DIAGNOSIS OF DIABETES,
THOSE WITH MEETING THE OUTCOMES
WE HAVE A SAMPLE OF OVER 80,000
INDIVIDUALS IN OUR ANALYSIS AND
FROM HERE, I PRESENT YOU THE
ANALYSIS CELLS AND THIS IS
SHOWING YOU THAT PRE DIABETES IS
A SIGNIFICANTLY ASSOCIATED WITH
WAYS OF CHRONIC HEART DISEASE
AND STROKE AND COMPOSED OUTCOME
IN WOMEN.
BUT NOT IN MEN.
IT'S STRONGER IN WOMEN THAN IN
MEN.
WE FURTHER STRATIFIED RACIAL
GROUPS.
SIMILAR FINDINGS PRESENT HERE IN
WHITE AND THAT IS THERE IS A
SIGNIFICANT ASSOCIATION BETWEEN
PRE-DIABETES AND WE'RE SEVERE
OUTCOMES IN WHITE WOMEN BUT NOT
IN WHITE MEN AND NON HISPANIC
BLACKS, THE ASSOCIATION DID NOT
REACH STATISTICAL BLACKS AND
INDICATING BLACK WOMEN HAVE A
HIGHER RISK OF SEVERITY WITH
PRE-DIABETES.
NEXT, WE EXAMINED THE
ASSOCIATION OF UNDIAGNOSED
DIABETES AND EVEN MORE STRIKING
SEX DIFFERENCES APPEARED, SOME
ATTITUDES OF CARDIOVASCULAR RACE
ASSOCIATED WITH UNDIAGNOSED
DIABETES IS STRONGER IN WOMEN
COMPARED TO MEN.
SIMILAR FINDINGS APPEARED IN
RACIAL STRATIFIED ANALYSIS AND
ESPECIALLY NON HISPANIC WHITES.
THESE INCLUDE WOMEN SPECIFIC
CONDITIONS OR RISK FACTORS AND
THE POLICY CYSTIC OVARY
SYNDROME, PCOS, GESTATIONAL
DIABETES, REPRESENT INTER PLAY
OF SEX, HOR MONTHS AND MASS
KULAR DYSFUNCTION AND INSULIN
RESISTANCE.
AND SOME RESEARCH ALSO SUGGESTS
THAT WOMEN HAVE A HIGHER
SUSCEPTIBLE TO PSYCHO SOCIAL
STRESS AND THERE ARE SEX
DIFFERENCES IN NONTRADITIONAL
RISK FACTORS AND SUCH AS
BIOMARKERS IN INFLAMMATION,
FUNCTION, AND THERE ARE ALSO
GENETIC INFLUENCERS AND SO NEW
ASSOCIATION STUDIES AND THEY
FOUND SPECIFIC IN INVOLVED IN
THE REGULATORY FUNCTIONS OF ADD
A POSE AND INSULIN BIOLOGY AND I
WAS MORE AND MORE STUDIES, THESE
SEX SPECIFIC IS A CAUSEWAY OF
DIABETES CAN BE FURTHER
EXPLAINED.
TO SUMMARIZE, THE HIGHER
CARDIOVASCULAR RACE ASSOCIATED
WITH DIABETES IN WOMEN IS DUE TO
POOR MANAGEMENT AND TREATMENT
AND MORE SO DUE TO BIOLOGICAL
DIFFERENCES BETWEEN SEXES.
WOMEN HAVE A GREATER DOUGH
TIERATION IN RISK FACTORS BEFORE
DIABETES AND PRE-DIABETES AND
UNDIAGNOSED DIABETES HAVE A
STRONGER ADVERSE IMPACTS ON
CARDIOVASCULAR RATES IN WOMEN
COMPARED TO WOMEN SUCH AS THE
IMPORTANCE OF DIABETES SCREENING
AND EARLY INTERVENTION TO
PREVENT OR DELAY THE ONSET OF
DIABETES AND PARTICULARLY IN
WOMEN.
THERE ARE DEFINITELY MOR WORK TO
GO DOWN TO EXPLAIN AND REDUCE
THIS SEX DISPARITY.
THIS INCLUDES IDENTIFYING SEX
SPECIFIC RISK FACTORS FOR
DIABETES DIAGNOSIS AND
PROGNOSIS.
WITH MORE EMPIRICAL EVIDENCE,
RESEARCHERS CAN DESIGN AND
IMPLEMENT SEX AND EDUCATION AND
SUPPOSE SORT PROGRAMS AND FOR
PEOPLE WITH HIGH-RISK OF
DIABETES AND SEVERITY.
I WANT TO THANK AGAIN FOR THE
SUPPORT FROM THE NIH OFFICE OF
RESEARCH AND WOMEN'S HEALTH AND
ALSO OUR PROGRAMS.
THAT SUPPORTS AND FOUND MY
RESEARCH IN SEX DIFFERENCES OF
DIABETES AND CARDIOVASCULAR
COMPLICATIONS AND I'M VERY
GRATEFUL FOR THE SUPPORT FROM
ALL THE BIRCWH ASSOCIATES AT
TULANE.
ALSO I THANK MY COLLABORATORS
AND OTHER FUNDING SOURCES THAT
SUPPORTED MY RESEARCH PROGRAM.
AND ALSO, THANK YOU FOR YOUR
ATTENTION AND BEING HERE FOR MY
PRESENTATION AND WELCOME ALL THE
COMMENTS AND QUESTIONS.
>> THANK YOU SO MUCH.
LISA BEGG HERE, IF I CAN ASK THE
THREE PODIUM SPEAKERS TO PUT
THEIR CAMERAS ON AND IT WILL BE
JUST I THINK THE FOUR OF US ON
THIS SCREEN AND WE HAVE ONE
QUESTION THAT IS COMING IN BUT I
JUST WANT TO STATE, THAT WE'RE
HEARING FROM SOME OF YOU THAT I
GUESS THERE'S A Q&A TAB OR A
SECTION THAT YOU ARE PUTTING
QUESTIONS IN AND SOMEHOW WE,
MEANING THE NIH FOLKS IN OUR
CONTRACTORS, DON'T SEE SO
THEY'RE DOING SOME
TROUBLESHOOTING AND WE HOPE TO
GET THAT REINVOLVED.
IF WE DON'T, WE'LL ASK THE
VIRTUAL FOLKS IS THAT THEY
CAPTURE THE QUESTIONS AND WE'LL
GET BACK TO YOU.
THIS IS A MYSTERY TO US.
THERE'S ONE QUESTION THAT CAME
IN AND SO FASCINATING FINDINGS
ON THE HIGHER CO MORBID RISK IN
PREGNANT WOMEN STARTED ON MEDS
POST DISCHARGE.
BY ANY CHANCE, DID YOU LOOK AT
FACTORS SUCH AS SEX IS THE BABY,
SINGLETON VERSUS NON SINGLETON
BIRTH, FIRST OR PRIOR PREGNANCY
ACROSS COHORTS.
>> YEAH, THANK YOU SO MUCH FOR
THAT QUESTION.
SO, WE DID LOCK AT SOME OF THE
FACTORS AND I APOLOGIZE -- I
DIDN'T SHOW THAT DATA BUT IT
WASN'T DIFFERENT SO LOOKING AT
FEMALE VERSUS MALE SEX.
WE HAVE NOT LOOKED AT
SINGLETON'S VERSUS MULTIPLES
WHICH I THINK IS A REALLY
INTERESTING QUESTION AND IT'S
OBVIOUSLY GOING TO BE A
RELATIVELY SMALL NUMBER ARE YOU
ALSO LOOKING AT OTHER METRICS
LIKE CAREGIVING INTENSITY, WHICH
THEY'RE DEFINING AS CARE, THE
NUMBER OF CAREGIVING TASK
PERFORMED.
DO YOU HAVE ANY COMMENTS ON
THAT?
>> YEAH, IT'S A REALLY GOOD
QUESTION AND UNFORTUNATELY THE
HRS DOESN'T REALLY ALLOW US TO
DISAGGREGATE WHICH TASK PEOPLE
ARE HELPING WITH AND WE DO HAVE
INFORMATION ON WHICH SPECIFIC
DISABILITIES PEOPLE ARE HELPING
WITH AND SO WE CAN GET A LITTLE
BIT AT THAT BUY LOOKING THE THE
NUMBER OF DISABLING CONDITIONS
THAT OLDER ADULTS ARE
EXPERIENCING AND COMPARE THAT TO
THE NUMBER OF HOURS THAT
CAREGIVERS ARE REPORTING.
YOU KNOW, I'VE TRIED TO LOOK AT
CAREGIVING INTENSITY AND SOME
OTHER RESEARCH AND WHAT WE'RE
FINDING IS THAT IT'S, YOU KNOW,
THERE ARE SPECIFIC DISABILITIES
ASSOCIATED WITH GREATER
CAREGIVING INTENSITY AND
SPECIFICALLY THOSE HELPING WITH
BATHROOM AND TILE ETING TASKS
AND INDIVIDUALS TO NEED HELP
EATING AND THOSE TWO SEEM TO
STICK OUT AS VERY, VERY
IMPORTANT IN TASKS THAT MIGHT
REPLAYER, A EXAMINATION SO WE
DON'T HAVE SPECIFIC INFORMATION
ON WHICH ADO DISABILITIES ARE
PEEPING ARE HELPING WITH, PEOPLE
ARE EXPERIENCES PARTICULAR
DISABILITIES.
>> GOOD, THANK YOU.
I HOPE THAT ANSWERS THE
QUESTION.
A QUESTION ABOUT THE SEVERE
MEDICINMETABOLIC PHENOTYPES AND IF IT'S
CORRECT, THE METABOLIC SYNDROME
SEVERITY DO YOU WANT TO
IMPLEMENT THAT A LITTLE BIT.
>> YES, SO THIS IS A QUESTION I
THINK MANY PEOPLE ARE
SPECULATING FOR ALMOST 10 YEARS
IN THE LITERATURE.
THAT S. YOU KNOW, WHEN THEY
FOUND THAT THERE'S A SEX
DISPARITY THAT WOMEN TEND TO
HAVE A HIGHER RATE OF CHD AFTER
THEY DYING KNOWS WITH DIABETES
AND THEN PEOPLE ARE SPECULATING
THAT SO BEFORE, AT THE TIME OF
DIAGNOSIS, DO WOMEN ALREADY HAVE
A WORSE METABOLIC RISK PROFILE
COMPARED TO MEN THAT THEY
ALREADY SITTING ON THE WORSE
SHAPE AND WHICH YOU KNOW, THE
PRO DISPOSED THEM TO A HIGHER
RISK OF CBD SO OUR ANALYSIS
USING THE DATA COHORT IS REALLY
TRYING TO VERIFY THIS HYPOTHESIS
AND WE DID FIND THAT YOU KNOW,
USING THIS COMPOSITE INCLUDING
ALL THOSE TRANSITIONAL RISK
MARKERS WE FIND THAT WOMEN'S
METABOLIC SEVERITY THEY
DETERIORATED IN A FASTER RATE
COMPARED TO MEN IN THE
PRE-DIABETES STATE.
SO THIS IS, I THINK THIS IS NOT
OUR ORIGINAL HYPOTHESIS BUT WE
DID USE A VERY GOOD COHORT DATA.
>> GOOD, THANK YOU.
VERY COMPLICATED SITUATION TO
TRY TO ANNA TO AN ANALYZE, WE HAVE ANOTHER Q
DO YOU WANT ME TO READ IT TO
YOU?
>> I THINK I SEE IT.
>> IF THE FREQUENCY OF
MEDICATION ADMINISTRATION OR
PERCEIVED BURDEN WAS ASSESSED
FOR THOSE ON MEDICATIONS POST
DISCHARGE AND YES, YOU KNOW,
MOST OF THE APPROVED MEDICATIONS
ARE NOT EXTENDED WHICH COULD
REQUIRE MULTIPLE PILLS MULTIPLE
TIMES A DAY THAT IS VERY TRUE
AND WE CERTAINLY NEED BETTER
PHARMACOLOGIC AGENTS THAT HAVE
GOOD SAFETY DATA FOR USE IN
PREGNANCY AND IN BREASTFEEDING
AND SO WE ASSESSED BURDEN OF --
WE DIDN'T SPECIFICALLY SEPARATE
MEDICATIONS FROM BURDEN OF
PARTICIPATION IN THE PROGRAM,
BUT WE ASSESSED BURDEN OF
PARTICIPATE IN THE PROGRAM WHICH
INCLUDES TAKING MEDICATIONS,
MEASURING BLOOD PRESSURE, AND WE
HAVE VERY FAVORABLE DATA FROM
THAT IN TERMS OF PARTICIPANTS
RECORDING THE HIGH SATISFACTION
WITH PARTICIPATION AND I WILL
SAY IN TERMS OF KIND OF OUR
PRACTICE, THE MAJORITY OF PEOPLE
WHO ARE STARTING ON MEDICATIONS
POST HOSPITAL DISCHARGE WE TRY
TO USE EXTENDED RELEASE
MEDICATION AND SO THAT
TWO-THIRDS OF PEOPLE WHO ARE
STARTING ON MEDICATIONS, AFTER
HOSPITAL DISCHARGE WERE STARTED
ON THAT BECAUSE OF THE INCREASE
CLEARANCE IN THE POSTPARTUM
STATES IT HAS TO BE TWICE A DAY
CLOSINCLOSE DOSING BUT IT'S MORE
COMMON DATA BLOCKERS WHICH MIGHT
BE THREE TIMES A DAY WHICH IS A
SIGNIFICANT BURDEN FOR
INDIVIDUALS THAT MAY ALSO BE
CARRYING FOR A NEWBORN OR HAVE A
BABY IN THE NICU SO IT'S A GREAT
POINT AND IT HIGHLIGHTS THE FACT
THAT THIS IS A REALLY VERY UNDER
STUDIED AREA AND IN REGARDS TO
MEDICATION AND SAFETY AND IT
ENDS UP INCREASING BURDEN ON
PREGNANT AND POSTPARTUM
INDIVIDUALS.
>> THANK YOU FOR THAT AND JUST
HIGH COMMENTARY AND I HOPE YOU
WILL CONTINUE TO STUDY THIS
BECAUSE IT SEEMS THERE SHOULD BE
SOME POLICY CHANGES SO IT'S
REALLY A PUBLIC-HEALTH ISSUE AS
WELL IS THE MEDICAL MANAGEMENT
ISSUE, DO YOU WANT TO COMMENT ON
THAT?
>> I THINK I AM AT AN
INSTITUTION THAT HAS THIS KIND
OF ROBUST HOME BLOOD PRESSURE
MONITORING PROGRAM AND WHO HAS
REALLY INVESTED BEING ABLE TO DO
THIS FOR OUR PATIENTS BUT I
THINK THAT IS NOT THE CASE
EVERYWHERE AND THERE'S A LOT OF
AREAS IN THE COUNTRY THAT DON'T
HAVE ACCESS TO BLOOD PRESSURE
COX THAT MAY NOT HAVE BROADBAND
ACCESS TO SEND IN BLOOD PRESSURE
TO THEIR CARE TEAM.
MOST IN 99% OF HEALTH INSURANCE
WON'T COVER HOME MONITORING OR
BLOOD PRESSURE MANAGEMENT WHEN
IT'S DONE REMOTELY AND NOT DONE
IN A PHYSICAL OFFICES AND SO
THERE'S CERTAINLY MAJOR POLICY
IMPLICATIONS THAT REALLY LIMIT
THE ABILITY OF A LOT OF THE
POPULATION TO BE ABLE TO ACCESS
THIS TYPE OF CARE AND MANAGEMENT
THAT I THINK OUR DATA SUGGESTS
THAT IS PROBABLY REALLY CRITICAL
AND ACTUALLY STARTING TO REDUCE
HYPERTENSION RELATED MORBIDITY
IN THE POSTPARTUM PERIOD.
>> ONE FINAL PLUG FOR ORWH, WE
HAVE A CENTRAL WEBSITE ON OUR
HOME PAGE AND Dr. CLAYTON HAS
WORKED ACROSS NIH IN ACTUALLY
ACROSS THE FEDERAL GOVERNMENT SO
THIS IS AN AREA IN GENERAL,
MATERNAL MORBIDITY AND MORTALITY
THAT OUR OFFICE TAKES SERIOUSLY
SO THANK YOU FOR THAT.
Dr. CANTU, I THINK IT'S A
COMMENT FROM Dr. MACKIE.
THANK YOU FOR YOUR WORK IN THIS
AREA AND IT FILLS AN IMPORTANT
GAPS.
THE OTHER WORK, DAUGHTERS
PROVIDE MORE CARE THAN SONS SO
BURDEN THERE AND WOMEN IS
HIGHER.
DO YOU WANT TO COMMENT ON THAT.
>> I THINK IT'S AN IMPORTANT
POINT AND I THINK IT'S ONE OF
THE THINGS MISS INTERESTING THIS
CURRENT ALANAL SIS IS WE AREN'T
LOOKING CAREGIVERS BEYOND
CATEGORIZING THEM AS SPOUSES,
CHILDREN, NON FAMILY MEMBERS,
OTHER FAMILY MEMBERS BUT I THINK
THERE'S IMPORTANT WORK TO BE
DONE THERE AND LOOKING AT THE
GENDER OF THE ACTUAL CAREGIVERS
THEMSELVES AND ANY SENSE IS THAT
THE VAST MAJORITY OF THE CARE
THAT'S BEING DELIVERED IN THIS
POPULATION IS COMING FROM
DAUGHTERS AND WIVES SO YOU KNOW,
I THINK THAT ONE OF THE SORT OF
OUTSTANDING QUESTIONS THAT I'M
LEFT FROM THIS RESEARCH IS SO,
WE GET THIS SENSE THAT WOMEN ARE
DELIVERING MORE CARE AND WOMEN
ARE NEEDING MORE CARE BUT WHAT I
REALLY WANT TO KNOW AND WHAT
RESEARCH HAS KIND OF NOT GOT TO
IS WHAT IS THE NET EFFECT OF
THESE CAREGIVING RELATIONSHIPS
AND OF THIS CARE SO IS THIS CARE
LEADING TO BETTER OUTCOMES?
SOME RESEARCH LOOKING AT
INFORMAL CARE HAS SHOWN THERE'S
NOT REALLY A RELATIONSHIP WITH
REDUCING MEDICARE COSTS BUT IT
DOESN'T GET AT THE OUTCOME.
THAT I MENTIONED.
HOW DOES IT EFFECT PEOPLE'S
WELLBEING AND WHILE THEY'RE
EXPERIENCING HEALTH PROBLEMS?
HOW DOES IT EFFECT PEOPLE'S
WELLBEING SORT OF LONG-TERM AND
I THINK THAT THE HRS MIGHT BE
ONE AVENUE WE CAN GET THOSE
QUESTIONS.
>> ANOTHER IMMENSE PROBLEM FOR
RESEARCH AND PUBLIC-HEALTH
IMPLICATIONS SO THANK YOU FOR
THAT.
WE HAVE TIME FOR ONE MORE
QUESTION SO I'M GOING TO GO TO
YOU.
YOU MENTIONED SOMETHING ABOUT
POOR MANAGEMENT AND TREATMENT
AND DO YOU COMMENT ON THAT.
WAS IT JUST ANECDOTAL OR --
>> YES, YES, ABSOLUTELY.
SO, WE KNOW THERE'S A HISTORICAL
GAP THAT WOMEN RECEIVES LESS
AGGRESSIVE TREATMENTS ON THE
RISK FACTORS.
SO, I'M NOT AN EXPERT IN THIS
FIELD BECAUSE I FOCUS ON
BIOLOGICAL RISK FACTORS BUT I
THINK YOU KNOW, EVEN IN THE PAST
20 YEARS WE'VE SEEN THIS GAP IS
GETTING SMALLER AND STILL, I
THINK WOMEN STAND IN A
DISADVANTAGE IN TERMS OF
MANAGEMENT AND TREATMENTS AND SO
THIS IS IMPLICATED IN COVID-19.
PART OF MY RESEARCH IS SEEING
THE SEX DIFFERENCES IN CHRONIC
DISEASE MANAGEMENT DURING
COVID-19 AND WE SEE THAT YOU
KNOW, THESE CHRONIC CONDITIONS
ARE POORLY MAN NOTED IN WOMEN
COMPARED TO MEN WHICH LEAD TO
MORE SEVERE OUTCOME IN WOMEN SO
I THINK MAYBE IF IT'S GOING TO
BE DELIBERATED IN MY DIABETES
RESEARCH A LITTLE BIT.
>> GOOD AND WE'LL BE HAPPY TO
HELP FACILITATE WITH ALL OUR
SCHOLARS THE INTERACTIONS WITH
OUR IC PARTNERS SO FEEL FREE TO
LET US KNOW AND WORK WITH YOUR
PIs AND SO FOURTH.
I WANT TO THANK ALL THREE OF YOU
FOR A WONDERFUL SESSION.
AND WE APPRECIATE IT VERY MUCH.
AND I AM GOING TO TURN IT OVER
INFORM Dr. TIGNO FOR OUR
LEGACY OF LEADERSHIP.
>> THANK YOU, LISA AND HELLO
AGAIN, EVERYONE.
IN 2020, ON THE 30th
ANNIVERSARY OF THE ORWH AND THE
20th ANNIVERSARY OF THE BIRCWH
PROGRAM, Dr. JANINE CLAYTON
CREATED THE LEGACY OF LEADERSHIP
LECTURE TO HONOR WOMEN RESEARCH,
RESEARCH ADMINISTRATION AND
ADVOCACY.
EACH YEAR SINK THE ORWH INVITES
A DISTINGUISHED FEMALE SCIENTIST
WHO NOT ONLY EXEMPLIFIES WHAT WE
AS PAIR FOR AS SCIENTISTS BUT
ALSO EMBODIES REMARKABLE
LEADERSHIP SKILLS THAT INSPIRE
AWFUL US TO CREATE AND
CONTRIBUTE TO A BETTER AND
HEALTHIER FUTURE.
IN THE PAST, WE WERE HONORED TO
HAVE Dr. CLAIRE STICK STIKR AND CREDIT -- THIS YEAR
IT'S MY PRIVILEGE TO INTRODUCE
Dr. JUDITH A. JAMES, VICEROYS
OF CLINICAAT THEOKLAHOMA MEDICAL RESEARCH
FOUNDATION OR OMRF.
SHE'S ALSO THE ASSOCIATE VICE
PROVOST FOR CLINICAL
INFORMATIONAL SCIENCE AND
PROFESSOR OF MEDICINE IN
PATHOLOGY AT THE UNIVERSITY OF
OKLAHOMA HEALTH SCIENCES CENTER.
Dr. JAMES GRADUATED FROM THE
OKLAHOMA BAPTIST UNIVERSITY AND
THE FIRST GRADUATE OF THE
UNIVERSITY OF OKLAHOMA PROGRAM
AND SHE COMPLETED HER INTERNAL
RESIDENCY AND HUM Dr. JAMES
RESEARCH IS FOCUSED ON DISEASES
THAT ARE IN WOMEN.
A PRACTICE BEING RHUMATOLOGIST,
SHE SEEKS TO UNDERSTAND THE
IDEOLOGY AND PATHOGENESIS OF
LUPUS, MECHANISMS OF AUTO
ANTIBODIES IN SYSTEMIC DISEASE
AND THE INTER PLAY OF GENETIC
RISK AND ENVIRONMENTAL RESPONSES
IN SYSTEMIC AUTOIMMUNITY AND THE
UNIQUE DRIVERS OF DISEASE
SEVERITY IN NATIVE AMERICAN
AUTOIMMUNE RHEUMATIC DISEASE
PATIENTS.
SHE HAS MADE CONTRIBUTIONS TO
UNDERSTANDING ALL AUTOIMMUNE
DISEASES START AND THE CONCEPT
OF EPITOPE SPREADING AND EARLIER
IN HER CAREER, AND A YEAR AFTER
MEDICINE SCHOOL, SHE RECEIVED
THE PRESTIGIOUS PRESIDENTIAL
EARLY CAREER AWARD FOR
SCIENTISTS AND ENGINEERS.
Dr. JAMES HAS RECEIVED WHAT
MANY OF US DO NOT EVEN DARE TO
DREAM OF, A MILE-LONG LIST OF
NIH FUNDED GRANTS FROM MULTIPLE
INSTITUTES OF THE NIH AND NOT
JUST THE AREs BUT Us AND
Ps WHICH ARE CURRENT, PEND
ORGANIZE COMPLETED.
SHE HOLDS A DOZEN PATENTS OR
MORE AND IN ADDITION TO HAVING
PUBLISHED OVER 330 SCIENTIFIC
ARTICLES.
Dr. JAMES' CV IS 90 PAGES LONG
AND SHE'S THE BRING PEL PRINCIPLE FOR SEVE RAL
GRANTS TO INCLUDED AMONG THEM
ARE THE U54 OKLAHOMA SHARED
CLINICAL AND TRANSLATIONAL
RESOURCES, GRANT FROM NIH EMS
AND THE AUTOIMMUNITY CENTER OF
EXCELLENCE FROM NIAID WHERE SHE
IS THE NATIONAL CLINICAL
CO-CHAIR AND THE UC HE CAN SELL
RATING MEDICINE PARTNERSHIP IN
AUTOIMMUNE MITIGATE DISEASES OR
THE AMP-AIM, WHICH IS FUNDED
FROM THE FOUNDATION FOR NIH AS
WELL AS IN COLLABORATION WITH
SEVERAL NIH CENTERS AND
PARTICULARLY THE NAIMS AND WHERE
SHE SERVESES A THE NATIONAL
CHAIR AND THE RHEUMATIC DISEASE
RESEARCH COURSE FROM NAIMS.
OF NOTE, Dr. JAMES ALSO IS
INVOLVED IN STRENGTHENING THE
BIOMEDICAL RESEARCH CAPACITY AND
TRAINING OF ETHNIC MINORITIES IN
THIS CASE, MOSTLY NATIVE
AMERICANS FROM SUPPORT FROM A
SUPPLEMENT GRANT FROM NIGMS.
Dr. JAMES CONTINUES TO REAP
MULTIPLE NATIONAL AND
INTERNATIONAL AWARDS AND
INCLUDING THE LECTOR SHIP FROM
THE AMERICAN COLLEGE OF RUM A
TOLL GOUGH AND THE EVELYN HESS A
WORD FOR LUPUS RESEARCH AND THE
STANLEY COURSEMIRE AWARD FROM
THE AMERICAN SOCIETY OF CLINICAL
INVESTIGATIONS.
SHE WAS A MEMBER OF THE NAIMS
COUNCIL AND SERVED AS THE
ELECTED SECRETARY, TREASURER OF
THE AMERICAN SOCIETY OF CLINICAL
INVESTIGATION.
AND AS Dr. CLAYTON MENTIONED
EARLIER, SHE WAS ELECTED TO THE
NATIONAL ACADEMY OF MEDICINE AND
ALSO TO THE ASSOCIATION OF
AMERICAN PHYSICIANS.
LADIES AND GENTLEMEN, Dr.
JUDITH JAMES.
>> HELLO THANK YOU FOR JOINING
US TODAY AND I'M VERY EXCITED
AND ACTUALLY VERY HONORED TO BE
ASKED TO GIVE THIS LECTURE.
SO, I'M GOING TO TALK JUST
BRIEFLY ABOUT KIND OF THE
WINDING ROAD TO RESEARCH AND
SOME LESSONS THAT I'VE LEARNED
ALONG THE WAY.
SO I HAD TO HAVE A LITTLE BIT OF
SCIENCE BECAUSE YOU CAN'T GIVE A
SCIENTIST POWERPOINT SLIDES AND
NOT LET US SHOW SCIENCE BUT ALL
OF THE RELATE BACK TO SOME OF
THESE LESSONS.
AND SO, ONE OF THE FIRST LESSONS
THAT I'D LIKE TO TALK ABOUT IS
THERE ARE MANY, MANY DIFFERENT
PATHS.
IN RESEARCH AND YOU JUST HAVE TO
FIND YOUR OWN WAY.
ALL OF THIS WILL HAVE
DIFFERENCES.
I GREW UP A FARM OUTSIDE OF A
TOWN LESS THAN 1,000 PEOPLE AND
I WAS SO I FEW FROM A YOUNG AGE
BECAUSE I HAD SEVERE ASTHMA I
WANTED TO BE A PHYSICIAN.
I TOLD MY PHYSICIAN THIS AND I
TOLD ME IF I WOULD BE A NURSE HE
WOULD BE HAPPY TO HIRE ME IN A
COUPLE DECADES BUT I NEVER
SWAYED FROM THAT PATH OF WANT TO
GO DO WHAT I THOUGHT WAS
MEDICINE BUT THE FIRST I ROUNDED
WITH A PHYSICIAN THEY SAID I
ASKED TOO MANY QUESTIONS TO WANT
TO PRACTICE FOR ALL MY LIFE SO
THEY ENCOURAGED ME TO FIND A
RESEARCH OPPORTUNITY AND SO FOR
THOSE OF YOU THAT MAY NOT HAVE
SUCCEEDED THE VERY FIRST TIME
THAT YOU A EMPLOYED TO
SOMETHING, I ACTUAL LOW HAD TO A
PLOY THROW TIMES TO BE SELECTED
FOR SOME UNDERGRADUATE RESEARCH
PROGRAM AND IT WAS BECAUSE I
CAME FROM A BACKGROUND WHERE I
DIDN'T HAVE EXPOSURE FOR SCIENCE
EXCEPT FOR HAVING A PHENOMENAL
HIGH SCHOOL SCIENCE TEACHER.
I WAS DROPPED INTO AN NIH FUNDED
RESEARCH LAB AND I WANTED TO
WORK ON ALLERGY AND ACE MA BUT
THERE WAS NO ASTHMA RESEARCH
HAPPENING IN OKLAHOMA AND THAT
LED ME TO MY SECOND LESSON I'D
LIKE TO TALK ABOUT AND IT'S
ABOUT THE FACT THAT THE RESEARCH
ROAD IS MUCH EASIER WHEN YOU
REALLY FIND YOUR PASSION.
AND WHAT YOU ARE EXCITED ABOUT.
AND THAT SUMMER, I FOUND MY
PASSION.
THAT WAS AUTOIMMUNE DISEASES AND
SO AUTOIMMUNE DISEASES ARE WHEN
YOUR HUMAN IMMUNE SYSTEM ATTACKS
YOURSELF AND IT'S VERY, VERY
COMMON AND THIS ONE SAYS 1/5
IT'S PROBABLY 1/8 AMERICANS AND
OVER 75% OF THOSE HAPPEN TO
WOMEN IN WOMEN OF CHILD BEARING
AGE SO WE SEE SIGNIFICANT
ENRICHMENT IN COMMUNITIES OF
COLOR AND SO AFRICAN AMERICAN,
NATIVE AMERICAN AND LATINO
PATIENTS AND SO THERE ARE MANY,
MANY DIFFERENT AUTOIMMUNE
DISEASES, PROBABLY OVER 80 AND
I'VE BEEN VERY INTERESTED IN
THIS SYSTEMIC AUTOIMMUNE
DISEASES AND HOW, EVEN WITH THIS
SAME GENETIC PREDICTION
POSITION, THAT SOME PATIENTS MAY
END UP WITH ONE AUTOIMMUNE
DISEASE WHILE OTHERS END UP WITH
ANOTHER AUTOIMMUNE DISEASE AND
SO I FOLLOWED AS A PATIENT UNTIL
SHE PASSED AWAY TWO YEARS AGO
AND THE OTHER DIED THAT SUMMER.
AND SO, THAT REALLY SPARKED MY
INTEREST IN HOW CONDITIONS IT'S
THE SAME DISEASE COULD EFFECT
TWO PATIENTS SO DIFFERENTLY AND
BOTH OF THOSE PATIENTS HAD AN
AUTOIMMUNE DISEASE CALLED
SYSTEMIC LUPUS AND SO LUPUS IS A
CLINICALLY AND BIOLOGICALLY VERY
DIVERSE AUTOIMMUNE DISEASE WITH
THIS COMPLEX PATHOGENESIS AND IT
EFFECT EVERY ORGAN SYSTEM IN THE
BODY THAT HAS THIS BEAUTIFYING
FEATURE OF AUTO ANTIBODY AND
PRODUCTION AND MOST PEOPLE DON'T
REALIZE THAT LUPUS ACTUALLY
STILL REMAINS EVEN THOUGH WE'VE
MADE LOTS OF ADVANCES IN THE
LAST 60 YEARS AND IT STILL
REMAINS A TOP 10 MEDICAL CAUSE
OF DEATH IN YOUNG WOMEN AND
ESPECIALLY IN YOUNG WOMEN
BETWEEN 15 AND 45 YEARS OF AGE.
AND YOU CAN SEE HERE THAT IN 15
TO 25-YEARS-OLD, IT'S ONE OF THE
TOP 10 IN ALL FEMALES BUT IT'S
THE FIFTH HIGHEST CAUSE OF DEATH
IN BLACK FEMALES AND LATINA
PATIENTS AND SO THIS IS REALLY
SPURRED BY INTEREST AND LED ME
INTO A CAREER PATH WHERE I FOCUS
ON AUTOIMMUNE DISEASES AND I WAS
FORTUNATE TO BE THE FIRST PH.D
STUDENT AT THE UNIVERSITY OF
OKLAHOMA HEALTH SCIENCES CENTER.
WHILE I WAS DOING THAT, WE
DIDN'T HAVE A MSDP PROGRAM SO I
WAS ENCOURAGED TO WRITE A GRANT
AND WROTE A F31 THAT WAS FUNDED
IN THE SECOND YEAR OF MY
PROGRAM.
I WAS ABLE, EVEN WHILE DOING
SOME OF MY CLINICAL TRAINING, TO
RECEIVE LOCAL LUPUS FOUNDATION
AWARDS AND STATE AWARD AND THEN
THAT LED TO THE PRELIMINARY DATA
TO APPLY AND RECEIVE MY KO8 AND
THEN RO3 FOR KO8 RECIPIENTS AND
WHAT USED TO BE THE FIRST AWARD
WHICH IS AN R29 AND IT'S NOW
EVOLVED INTO THAT EARLY STAGE
INVESTIGATOR RO1 AND SO IN MANY
WAYS I WAS REALLY FORTUNATE TO
BE ABLE TO FOLLOW THIS KIND OF
THE NIH PATH TO BECOME AN
INVESTIGATORS AND SO THAT LED TO
RO1s AND MY FIRST INTERACTION
WITH THE OFFICE O OFFICE OF RESEARCH AND
WOMEN'S HEALTH AND IT LED ME TO
THIS NEXT LESSON I'D LIKE TO
TALK ABOUT WHICH IS THE RESEARCH
ROAD IS SELDOM STRAIGHT AND GOOD
THINGS CAN HAPPEN WHEN YOU
FOLLOW THE SCIENCE, HOPEFULLY
MANY OF YOU ALREADY LEARNED THIS
DURING YOUR TRAINING PROGRAMS
AND YOUR EARLY CAREER STAGES
BUT, I THINK THIS IS BEEN ONE OF
THE MOST EXCITING AREAS OF
RESEARCH IS NOW I KNOW THAT
THINGS WILL GO DIFFERENT
DIRECTIONS BUT EARLY IN MY
CAREER, I ALWAYS FELT LIKE WHEN
THINGS DIDN'T QUOTE-UNQUOTE WORK
OR WHEN WE DISPROVED THE
HYPOTHESIS AND INSTEAD OF
PROVING THE HYPOTHESIS, THAT
THAT WAS A STUMBLING BLOCK AND
NOW I UNDERSTAND THAT ALMOST ALL
OF THOSE LEADS TO OTHER
SCIENTIFIC OPPORTUNITIES
SOMETIMES THAT ARE EVEN BIGGER
THAN WHERE YOU REEL PLANNED ON
GOING YOURSELF.
SO WHEN I STARTED, WE WERE
EXCITED LEARNING WHERE OUR
ANTIBODIES WERE TARGETING SO
PART OF THE PROTEIN, MY
BACKGROUND WAS IN CHEMISTRY AND
SO WE BUILT TENS OF THOUSANDS OF
SOLID PHASED PEPTIDES WHERE WE
MAPPED WHERE THE ANTIBODIES WERE
FINDINGS SO IF THEY WERE
BINDINGS YOU WOULBINDINGS AND WE WOULD IDE NTIFY
THE COMMON TARGETS FOR OVER 20
DIFFERENT AUTO ANTIGENS BUT THIS
ALSO GAVE US AN OPPORTUNITY
BASED ON HAVING SERIAL SAMPLES
FROM PATIENTS OVER TIME TO BE
ABLE TO SEE HOW THEIR AUTOIMMUNE
REPERTOIRE CHANGED OVER TIME AND
AS THEY WERE ILL AND SO IN THIS
PATIENT, BEFORE SHE HAD ANY
SYMPTOMS, BEFORE WE MADE THIS
AUTO ANTIBODY SHE WAS THE SISTER
OF A LUPUS PATIENT AND SHE DID
NOT HAVE A BINDINGS TO THESE
PEPTIDES AND THIS PROTEIN WHICH
IS PART OF THE COMPLEX AND THEN
WHEN SHE FIRST STARTED
DEVELOPING SYMPTOMS AND HAD ANTI
SM, SHE MADE ANTIBODIES THAT
REALLY STRONGLY BOUND TO THESE
PEPTIDES AND THAT ACTUALLY WAS A
REPEATED MOTIF THAT HAD RICH AND
OR PDPGMRP AND THEY MADE
ANTIBODIES THAT TARGETED THIS
PROTEIN UNTIL SHE HAD A DIVERSE
RESPONSE WHEN SHE WAS IN THE ICU
AND WE'VE GONE AHEAD AND THIS IS
NOW BEEN DECADES AGO AND LOOKED
AT OTHER ANTIGENS AND IN
AUTOIMMUNE DISEASES WE FOUND
THAT WE HAD THIS SIMILAR KIND OF
EPITOPE SPREADING WHERE WE WENT
FROM HAVING NO ANTIBODIES TO
BINDING KIND OF A LIMITED PART
OF THE PROTEIN SO HAVING DIVERSE
RESPONSES AND IT WAS VERY
INTERESTED IN WHAT TRIGGERS
THESE VERY EARLY RESPONSES AND
SO THIS WAS A PEPTIDE THAT IS
AMINO ACIDS STARTED WITH THEM SO
THIS IS A 60KD ROW AND WE
AFFINITY PURIFIED THIS ANTIBODY
AND SHOWED IT CROSS REACTED WITH
AN EPSTEIN BAR VIRUS AND WE
COULD IMMUNE ICE RABBITS AND
MOUSE STRINGS AND DEVELOP NOT
ONLY ANTIBODIES TO THE PEP SIDE
THAT WE WERE VACCINATING WITH
BUT ALSO THAT IN CERTAIN STRINGS
OF MICE AND IN RABBITS, THIS
WOULD DIVERSIFY AND BIND TO
OTHER PARTS OF THE PROTEIN AND
ALSO TO THESE CROSS REACTIVE
AUTO ANTIGENS AND SO THIS LED TO
THIS MOLECULAR HYPOTHESIS THAT
WE'VE BEEN ABLE TO DEMONSTRATE
FOR SEVERAL DIFFERENT ANTIGENS
BUT BEING ABLE TO GO BACK IN
TIME, AND REALLY THINK ABOUT
WHAT ARE THE FIRST THINGS GOING
WRONG, HAS REALLY BEEN A FOCUS
OF OUR RESEARCH AND THIS LED TO
A PARTNERSHIP WITH THE
DEPARTMENT OF DEFENSE AND THE
DEFENDANT OF DEFENSE HAS SAMPLES
WHEN YOU ENLIST INTO THE
MILITARY AND THEY HAVE ABOUT
EVERY TWO YEARS AFTERWARDS AND
WE PARTNERED WITH DEPARTMENT OF
DEFENSE RHUMATOLOGISTS AND WE
FOUND PATIENTS WHO LISTED INTO
THE MILITARY HEALTHY BUT LATER
BECAME LUPUS PATIENTS WE COULD
GET SERIAL SAMPL SAMPLES BEFORE DYING
KNOW SIS SO WE HAD SAMPLES
BEFORE DIAGNOSIS AND SOME AFTER
DIAGNOSIS AND WE NOW HAVE BEEN
ABLE TO LOOK AT 205 UNIQUE
INDIVIDUALS WHO DEVELOPED LUPUS
WHILE IN THE MILITARY AND WOVE
BEEN ABLE TO TRACK WHAT IS
HAPPENING IN THIS PRECLINICAL
TIME PERIOD AND SO SOME OF THESE
WERE VERY PRESENT IN 70% OF
PATIENTS FIVE YEARS BEFORE THEY
WERE A LUPUS PATIENT SO YOU CAN
SEE THEY'RE THAT EVEN FOR
ANTI-ROW AND ANTI LAW THAT 70%
OF THESE PATIENTS HAD THESE
ANTIBODIES FOR YEARS BEFORE THEY
WERE CLINICALLY SICK AND WE HAD
OTHER ANTIBODIES LIKE NTSM THAT
OCCUR CLOSE TO THE TIME OF
DIAGNOSIS AND THESE A AUTO ANTI-ED BO
HE'S HAVE UP TO THE TIME OF
DIAGNOSIS AND THEN THEY START TO
PLATEAU USUALLY WITH THERAPY.
AND SO, WE'VE GONE ON TO
CHARACTERIZE WHAT OTHER ASPECTS
OF THE IMMUNE SYSTEM IS CHANGING
BEFORE PATIENTS CLINICALLY ILL
AND WE SEE INCREASES IN CHANGES
IN THE INNATE IMMUNE SYSTEM AS
WELL AS IN DIFFERENT ASPECTS OF
THE ADAPTIVE T CELLS AND
CYTOKINES AS WELL AS TNF RELATED
MOLECULES AND WE SEE THIS LOSS
OF SOME ASPECTS OF IMMUNE
REGULATION.
THIS ALLOWED US TO PUT TOGETHER
PREDICTIVE MODELS FOR THE
TRANSITION TO LUPUS WHERE WE CAN
MERGE AUTO ANTIBODIES WITH THESE
DIFFERENT IMMUNE DIS-REGULATED
MOLECULES WITH THE MEDIATORS AND
DEVELOP BEYOND JUST WHAT WE
NORMALLY USE IN CLINICAL
PRACTICE WHICH IS JUST AUTO
ANTIBODIES TO GET TO WHERE WE
HAVE REALLY NICE SPECIFICITY AND
POSITIVE PREDICTIVE VALUE WHEN
WE ADD SOLO ABLE MEDIATORS TO
THESE AUTO ANTIBODIES SO WE'VE
GONE TO LOOK AT OTHER GROUPS OF
INDIVIDUALS WHO ARE AT HIGH-RISK
FOR LUPUS FOR INDIVIDUALS WHO
HAVE SYSTEMIC LOOP US AND THAT
LED TO THE CREE ACE OF LUPUS
FAMILY REGISTRY AN REPOSITORY WHO
LED PEOPLE FROM THE UNITED
STATES AND OTHER PLACES IN THE
GLOBE AND ALSO, THEY'RE
UNEFFECTED FAMILY MEMBERS AND SO
AFTER SIX YEARS WE WANTED TO
RECONTACT THE FAMILY MEMBERS AND
SEE IF WE HAD ANY AS WELL AS
OTHER SPECIMENS AND SEE HOW MANY
OF THEM CAN TRANSITION AND SO,
WE FOLLOWED THEM UP ABOUT SIX
AND A HALF YEARS LATER TO SEE
WHO TRANSITIONS AND THEY DIDN'T
TRANSITION AND WE CAN'T HERE AS
A POSITIVE RELATIVES THE BLOOD
RELATIVES AND THEN MATCH THOSE
AGAIN TO A AND A NEGATIVE TO
AUTO ANTIBODY NEGATIVE FAMILIES
MEMBERS AND THEY WERE MATCHED
BASED ON AGE, RACE, GENDER AND
THE THINGS YOU WOULD EXPECT AND
WHAT WE FOUND WERE THAT WE HAD A
NUMBER OF MOLECULES LIKE FOR
EXAMPLE, B STIMULATING FACTOR
WHICH WAS HIGHER SECURED BEFORE
AND THAT VICTIMS WHO TRANSITIONS
AND WHO DID NOT AND THE NEGATIVE
INDIVIDUALS, AND THIS WAS TRUE
FOR OTHER MOLECULES THAT ARE NOT
AS WELL STUDIED LIKE STEM CELL
FACT OR WHICH OTHER NAME IS LAG
INWHERE THIS INCREASES IN THE
STAIR STEP WAY AND WE ALSO
STRIKINGLY AWE THA -- THEY ARE MUCH
HIGHER IN THE AUTO ANTIBODY
NEGATIVE FAMILY MEMBERS COMPARED
TO THE AUTO ANTIBODY POSITIVE
MEMBERS AND THEY ARE STILL
HIGHER THAT WHAT WE SEE IN THE
PATIENTS WHO TRANSITION.
AND THIS SUGGESTS OR SUPPORTS
AND THEY ARE TRANSITION TO LUPUS
PATIENTS AND THEY ARE ABLE TO
COMPENSATE AND DECROWS SO WE
HAVE THIS DISREGULATION THAT
LEADS TO AUTOIMMUNITY SO THE
THINGS THAT COME INTO THIS MODEL
THAT MAKE THE BEST PREDICTION IS
A ELEVATION OF STEM CELL FACT OR
AND DECREASE THE TGF BETA SO
THIS IS LEFT US WITH THIS MODEL
WHERE YOU HAVE INDIVIDUALS WHO
HAVE GENETIC RISK WHO HAVE SOME
ENVIROMENTAL TRIGGERS AND AUTO
ANTIBODY PRODUCTION, PATHOGENIC
AUTOIMMUNITY AND CLINICAL
FEATURES OF DISEASE AND SO, THE
EXCITING PART OF THIS FOR ME AS
A CLINICIAN SCIENTIST THIS IS
BEEN ABLE TO HELP US IDENTIFY
HIGHER RISK INDIVIDUALS THAT WE
CAN ENROLL INTO A PREVENTION
STUDY AND SO THIS WAS THE FIRST
LUPUS PREVENTION STUDY THAT
HAPPENED AND FUNDED BY THE NIH
AND IT'S FOCUSED ON ENROLLING
INDIVIDUALS WHO HAVE ANTIBODIES
PLUS ONE OTHER CLINICAL FACTOR
AND WE'RE ENROLLING 240
INDIVIDUALS AND YOUR RANDOMIZED
TO RECEIVE HYDROXYCHLOROQUINE OR
BE CAREFULLY MONITORED FOR
INDIVIDUALS WHO TRANSITION AND
SO WE'RE TESTING THIS HIGH-RISK
SOL YOU ABLE MEET AIDER TO SEE
IF WE CAN IDENTIFY THESE AND
THIS PROVIDING US WITH AMAZING
SAMPLES TO BE ABLE TO STUDY
DIFFERENT HYPOTHESIS AND SO THIS
IS THE FOUNDATIONAL WORK WE DO
IN OUR LAB AND WE STILL DO A LOT
OF WORK FOCUSING ON EARLY
ASPECTS OF AUTOIMMUNITY AND
ENVIRONMENTAL TRYINGORS AND
MECHANISMS OF DISEASE FLARE AND
IMPROVING DISEASE OUTCOMES IN
THOSE PATIENTS AND DISEASE
QUALITY AND OF COURSE THE
PINNACLE WOULD BE FOR US IN
WORKING ON WAYS TO PREVENT
AUTOIMMUNE DISEASES AND SO, IN
ADDITION TO KIND OF DOING MY OWN
INDIVIDUAL RESEARCH WHICH OF
COURSE IS NEVER INDIVIDUAL
RESEARCH I'VE HAD WONDERFUL
PEOPLE WHO WORKED WITH ME OVER
THE YEARS IN THESE DIFFERENT
PROJECTS AND I ALSO HAVE BEEN
ABLE TO MO MORPH INTO DOING TEAM
SCIENCE AND SO THAT IS THROUGH
DIFFERENT TIMES OF U WARDS AND
LEADING OKLAHOMA EXCELLENCE AND
IT'S A U19 SO WE HAVE A
CONSORTIUM OF 10 DIFFERENT%
U19s ACROSS THE NATION AND
THAT IS LED US TO PARTICIPATE IN
TEAM SCIENCE AND TEAM SCIENCE IS
BROUGHT NEW TECHNOLOGIES THAT
ALLOW US TO BASICALLY GO DOWN
PATHS THAT I NEVER WOULD HAVE
EXPECTED AND I THINK THE BIGGEST
LESSON THAT I'VE LEARNED HERE IS
IN WORKING WITH ACCELERATING
MEDICINES PARTNERSHIP AND SO
THIS EXPOSED US TO THE NEW
SINGLE CELL TECHNOLOGIES THAT
STARTED COMING OUT SEVERAL YEARS
AGO NOW AND THAT WE'VE BEEN ABLE
TO APPLY TO OUR QUESTIONS WHICH
FOCUS ON OF COURSE, LUPUS
PATIENTS AND AUTO ANTIBODY
POSITIVE VERSUS NEGATIVE AND IN
THE INTEREST OF TIME, I'M GOING
TO FLY THROUGH THIS DATA BUT I'M
HAPPY TO ANSWER QUESTIONS OR IF
YOU ARE EXCITED ABOUT THIS AREA,
AS YOU CAN TELL I AM, DROP ME AN
E-MAIL AND WE CAN TALK ABOUT IT
OFF LINE SO WE'VE DONE A LOT OF
DIFFERENT TYPES OF DETAILED
IMMUNO MONITORING IN THIS
INDIVIDUALS TO SEE IF WE CAN
IDENTIFY WHAT IS IS UNIQUE ABOUT
THESE INDIVIDUALS.
THIS IS THINKING ABOUT SO FOR
THE IMMUNOLOGIST IN THE GROUP,
YOU HAVE HERE IN THE MIDDLE
WHERE WE'RE REALLY THINKING
ABOUT T CELLS AND YOU CAN SEE
THAT THE KIND OF INNATE CELLS
ARE OVER HERE ON THIS LEFT SIDE
AND THEN B CELLS ON THIS OTHER
SIDE AND JUST KIND OF IF YOU
LOOK AT THESE YOU CAN SEE WE SEE
A FEW DIFFERENCES BETWEEN A AND
A NEGATIVE AND A AND A POSITIVE
HEALTHY INDIVIDUALS WHICH THESE
WOULD USUALLY BE LUMPED TOGETHER
AND A DIFFERENCE IN THE B CELLS
IN LUPUS PATIENTS COMPARED TO
THE UNEFFECTED CONTROLS AND THE
OTHER THING TO POINT OUT IS
THESE TOP ONES ARE EUROPEAN
AMERICANS COMPARED TO THE
AFRICAN AMERICANS BELOW AND
THERE'S A DRAMATIC DIFFERENCES
BETWEEN THE TWO GROUPS AND THIS
IS ALLOWED US BY LOOKING AT
THESE POSITIVE HEALTHY
INDIVIDUALS AND TO START TRYING
TO ARE MORE ACCEPTABLE TO
DEVELOP LUPUS AND AND MANY OF
YOU ARE DOING AND YOU ARE SEEING
THESE KINDS OF ALL THE TIME NOW
AND THEY'RE NOT ON THE LEFT AND
T CELLS ARE ON THE RIGHT AND WE
HAVE THE LUPUS PATIENTS WHO ARE
IN GREEN COMPARED TO THE A AND A
POSITIVE WHO ARE IN BLUE AND THE
WHO ARE IN RED SO YOU CAN SEE
THAT THERE'S SOME PLACES WHERE
THINGS LOOK LIKE THEY MAY BE
ENRICHED AND IT GETS EASIER TO
SEE HERE THAT OF COURSE, WE SEE
MORE PLASMA CELLS, MORE MEMORY B
CELLS IN OUR LUPUS PATIENTS AND
THEN WE ALSO HAVE SOME AREAS
WHERE WE SEE EXPANSION OF
CERTAIN T-CELL SUBSETS AND LET'S
DEFINED IMMUNE CELLS IN THESE
AUTO ANTIBODY POSITIVE
INDIVIDUALS AND IF YOU LOOK, THE
TOP ONE IS LUPUS PATIENTS ASK IN
POSITIVE A AND A NEGATIVE THERE
ARE OFFICER THINGS HIGHER IN OUR
LUPUS PATIENTS BUT WE ALSO HAVE
THINGS THAT ARE REALLY
STRIKINGLY ELEVATED IN THESE A
AND A POSITIVE AND AGAIN, THIS
IS POINTING TOWARDS THOSE
REGULATORY PATHWAYS AND SO, THEY
HAVE NOW MORPHED INTO A NEW
COMPETITION FOR ACCELERATED
MEDICINES PARTNERSHIP INTO
AUTOIMMUNE AND IMMUNE RELATED
DISEASES AND I'M EXCITED ABOUT
THIS AND THIS REALLY FOCUSING ON
GOING BEYOND SINGLE CELL
TECHNOLOGIES AND LOOKING AT
SPACIAL AND USING SPACIAL
PLATFORMS TO ALL OF THE DISEASE
WE'RE STUDYING HAVE A FEMALE
PREDOMINANCE AND SO LUPUS IS THE
MOST STRIKING AT 9-1 AND CHOW
GRINS WHICH HAS A 7-1 AND NER A
LITTLE MORE EVENLY DISBURSED BUT
CLOSE TO TWO TO THROW TIMES MORE
LIKELY TO THE CURRENT LUPUS IN
I'M VERY FORTUNATE TO SERVE AS
THE DIRECTOR OF CONSORTIUM RIGHT
NOW AND WE HAVE TECHNOLOGY
SCORES WE SERVE AS THE
LEADERSHIP MANAGEMENT AND TISSUE
RESEARCH CORE AND WE HAVE
SYSTEMS BIOLOGY GROUPS SO THIS
BRINGS TOGETHER A LOT OF
DIFFERENT TYPES OF SCIENTISTS
AND ALL WITH THE COMMON PASSION
OF UNDERSTANDING JUST FROM A
COUPLE OF SMALL REGIONS OF
INTEREST AND I THINK THIS IS
GOING TO BE REALLY EXCITING AS
WE MOVE FORWARD.
THE OTHER THING I'D LIKE TO
POINT OUT, JUST BRIEFLY, IS AN
AMAZING PARTNERSHIP THAT IS
REALLY BEING LED BY THE OFFICE
OF RESEARCH IN WOMEN'S HEALTH
AND THIS IS THE NEW TEAM SCIENCE
LEADERSHIP SCHOLAR PROGRAM AND
THIS IS FROM MID LEVEL
INVESTIGATORS AND SCHOLARS WILL
LEAD PROJECTS THAT ARE
SYNERGISTIC OR BUILD ON THE
INFRASTRUCTURE THAT WE HAVE
DEVELOPED AND ARE DEVELOPING IN
AMP-AIM AND THIS PROVIDES
OPPORTUNITIES FOR WOMEN LEADERS
TO DEVELOP SKILLS AND TEAM
SCIENCE AND LEADERSHIP AND
MENTORING AND TO INTERACT WITH
ALL THESE DIVERSE INVESTIGATORS
NA ARE PART OF AMP-AIM THROUGH
THE GRANTS I SHOWED YOU AND THE
INDUSTRY PARTNERS AND THE
PRIVATE RESEARCH ORGANIZATIONSAL
S WITHAL WITH A DIVERSE NUMBER
OF NIH SCIENTISTS AND INSTITUTES
AND AND THE OFFICE OF RESEARCH
AND WOMEN'S HEALTH AND SO IN
THIS PROGRAM IT WILL BE A
NATURAL SEARCH AND MAYBE A
COUPLE INSTITUTIONS THAT ARE
ALREADY INVOLVED UNTIL THE
CAMPAIGN AND WE'RE ALSO LOOKING
FOR CANDIDATES OUTSIDE AND THEY
NEED TO BE INDIVIDUALS WHO ARE
BEYOND THOSE K YEARS AND REALLY
OUR ASSOCIATE PROFESSOR TO FULL
PROFESSOR AND THEY HAVE PROJECTS
OR QUESTIONS THAT CAN BE REALLY
INFORMATIVE WHEN WE'RE THINKING
ABOUT THESE OPPORTUNITIES
LOOKING ACROSS CORE DISEASES OR
LOOKING AT FEATURES THAT MIGHT
BE IMPORTANT ACROSS THE FOUR
DISEASES, FOR EXAMPLE,.
>> TO TAKE ON INSTITUTIONAL
LEADERSHIP OPPORTUNITIES.
AND SO, I WAS FORTUNATE TO BE A
TENURES PROFESSOR IN FIVE AND
BECOME A FULL RECOMMEND MEMBER
AT THE RESEARCH FOUNDATION IN
2006 AND SO I HAVE A FULL DUEL
APPOINTMENT IN THAT I WILL
ALWAYS BEEN ON FACULTY AT OUR
MEDICAL SCHOOL AND PLUS MY
RESEARCH LABS AND MY PRIMARY
APPOINTMENT IS A NON-PROFIT
RESEARCH FOUNDATION THAT IS
ACROSS THE STREET FROM OUR
MEDICAL SCHOOLS AND A OUR
MEDICAL CENTER AND IT'S CALLED
THE OKLAHOMA MEDICAL RESEARCH
FOUNDATION AND I KNEW THAT I
WANTED DO ADDITIONAL LEADERSHIP
AND SO I WENT AND TALKED TO OUR
ORGANIZATIONAL PRESIDENT AND
BECAME A DEPARTMENT CHAIR AND
CREATED A NEW DEPARTMENT IN 2009
STARTING WITH TWO P.I.s AND 45
PEOPLE AND I HAD A FEW
RECREWMENT LINES BUT ONE OF
THESE CURVES THAT CAN HAPPEN IN
YOUR RESEARCH PATH, WE HAD A
LARGE PROGRAM THAT THE
DEPARTMENT CHAIR LEFT QUICKLY
AND SO THAT, MY OLD DEPARTMENT
MERGED WITH THE NEW DEPARTMENT
AND WE WENT FROM HAVING TWO
P.I.s TO 12P.I. COMES 45 AND 45 PEOPLE TO
145 OVERNIGHT.
THERE WAS A LOT OF OPPORTUNITY
SERVING AS THE DEPARTMENT CHAIR
AND I AM VERY EXCITED TO STILL
BE SERVING AS THE DEPARTMENT
CHAIR FOR THE ARTHRITIS CLINICAL
IMMUNOLOGY RESEARCH PROGRAM
WHICH SPANS FROM BASIC
IMMUNOLOGY RESEARCH TO CLINICAL
INVESTIGATORS DOING CLINICAL
TRIALS OUTCOMES, RESEARCH AND
KIND OF EVERYTHING IN BETWEEN.
WE HAVE 18 FEDERALLY FUNDED
PRINCIPLE INVESTIGATORS AND WE
INCLUDE TWO DIFFERENT CLINICAL
CENTERS FOCUSED ON AUTOIMMUNE
DISEASES AND HAVE OVER 200
INDIVIDUALS CLOSE TO 210 WE
FOLLOW OVER 4,000 PATIENTS BOTH
IN RHEUMATOLOGY CENTER OF
EXPENSE WHERE I'M HOUSED AS WELL
AS IN A MULTIPLE SCLEROSIS
CENTER OF EXCELLENCE AND
LONGITUDINAL COHORTS WITH
PATIENT SAMPLES THAT ARE USED
ALL OF OUR BASIC INVESTIGATORS
AND AND THEN, I WAS FOR CLINICAL
TRANSLATION AT SCIENCE AT THE
UNIVERSITY OF OKLAHOMA AND WE
HAD HAD A GCRC PREVIOUSLY AND I
WAS PART OF THE GCRC AS A USER
NOT A LEADER AND THEN WE WERE
HAVING DIFFICULTY AND THEY ASKED
IF I WOULD WRITE THE CLINICAL
AND TRANSLATION AT RESEARCH
AWARD AND I CAN EXPLAIN THAT OFF
LINE IS ANYONE IS INTERESTED AND
IT PROVIDES A CLINICAL AND
TRANSLATIONAL RESEARCH SUPPORT
TO GROW THE CTR INFRASTRUCTURE
AND AS WELL AS TO PROVIDE
SUPPORT FOR PILOT PROGRAMS AND
TO MAKE OUTREACH SO WE BROUGHT
TOGETHER 29 DIFFERENT ENTRIES
WHO ALL FOCUSED ON THIS PASSION
TO IMPROVE THE HEALTH,
ESPECIALLY OF RURAL AND TRIBAL
ORGANIZATIONS AND WE HAVE A
NUMBER OF DIFFERENT TRIBAL
PARTNERS AND THIS IS BEEN REALLY
EXCITING AND THEN I WAS THE VICE
PRESIDENT OF CLINICAL AFFAIRS
HERE IN 2019 SO I'D LIKE TO
LEAVE YOU WITH THE LESSON THAT'S
PROBABLY THE MOST IMPORTANT AND
IT'S THAT THE PEOPLE YOU MEET
ALONG THE WAY THAT WILL MAKE
YOUR PATH WORTH WHILE AND SO I
HAVE BEEN VERY FORTUNATE TO HAVE
A NUMBER OF REALLY OUTSTANDING
MENTORS AND AS WELL AS
INSTITUTIONAL LEADERSHIP.
I'VE NEVER HAD AN OFFICIAL
MENTOR OR INSTITUTIONAL LEADER
WHO LOOKED EXACTLY LIKE ME I
HAVE MORE HAIR THAN MOST OF THEM
BUT I WANTED TO ENCOURAGE YOU TO
SERVE IN THIS ROLE TO BE
MENTORS, TO BE INSTITUTIONAL
LEADERS AND SO THAT WE CAN
EXPAND WOMEN'S HEALTH AND
WOMEN'S HEALTH RESEARCH AT OUR
INSTITUTIONAL LEFT AND
DEVELOPING THE NEXT GENERATION.
I'VE BEEN PASSIONATE ABOUT
HELPING OTHER TRAINEES SO I'VE
HAD OVER 130 STUDENTS AND
TRAINEES MAINLY UNDERGRADUATES
COME THROUGH MY LAB WHO MANY ARE
PHYSICIANS OR PH.D SCIENTIST TO
DO GRAD WORK PORK AND THEY HAVE
ALL COMPLETED ONE OF THOSE ARE
IN TRAINING AND THEY'RE
THROUGHOUT THE STATE OF OKLAHOMA
AND WE ONLY HAVE TWO COUNTRIES
THAT COUNT AS BEING URBAN
COUNTIES AND THEN WE HAVE
UNFORTUNATELY, A NUMBER OF
CHALLENGES IN OKLAHOMA INCLUDING
WE HAVE HIGH RATES OF POVERTY
AND WE HAVE MOST OF OUR STATE
ALMOST ALL OF OUR STATE
EVERYTHING THAT IS NOT READ HERE
IS CONSIDERED A HEALTH
PROFESSION SHORTAGE AREA AND SO
YOU CAN SEE THAT THESE COUNTIES
ARE THE ONES IN THIS COLOR BLUE
ARE THOSE THAT HAVE ALMOST NO
PHYSICIANS PROVIDE IS EVERYTHING
ADVISES IPROVIDING SERVICESAND THIS IS MY HOMETOWN AND MANY
OF MY TRAINEES HAVE GONE ON AND
DONE GREAT THINGS.
THEY'RE GREAT STUDENTS WHO HAVE
GONE ON TO HAVE FANTASTIC
INDIVIDUAL CAREERS.
I'VE HAD MANY DIFFERENT NATIVE
AMERICAN TRAINEES AND THEY'VE
GONE ON TO BE PH.Ds OR MDs
AND MANY OF THE MD-PH.D STUDENTS
WHO HAVE GONE ON TO FACULTY
POSITIONS AND PLACES FROM
HARVARD AND YALE TO UCSF SO I'D
LIKE TO END WITH JUST A FEW
LESSON THAT WE'VE TALKED ABOUT
ALONG THE WAY SO YOU HAVE A LOT
OF OPTION AND THERE ARE MANY
WAYS TO HAVE A VERY SUCCESSFUL
RESEARCH.
MY PATH IS MY PATH AND IT'S
DIFFERENT THAN MOST OF YOURS BUT
YOU WILL FIND YOUR WAY AND IT'S
IMPORTANT TO TALK TO OTHERS
ABOUT HOW YOU CAN FIND YOUR WAY
AND TO MAKE THOSE COURSE
CORRECTIONS AS YOU NEED TO AS
YOU TAKE THIS JOURNEY.
FOLLOW YOUR PASSION THAT'S
FUNDABLE AND IT'S REALLY
IMPORTANT TO FIND THE TYPE OF
SCIENCE YOU ARE REALLY
PASSIONATE ABOUT BECAUSE IT
HELPS YOU AND NO MATTER WHAT YOU
DID YOU SEE ARE WE HAVE A LOT OF
SCIENCE THAT NEEDS TO HAPPEN
INFORM THINK ABOUT NEW
APPROACHES AND THAT IS EASIEST
TO SEE THOSE IF YOU ENGAGE IN
TEAM SCIENCE WHERE YOU BRING
TOGETHER DIFFERENT TYPES OF
PEOPLE WHO HAVE HAD DIFFERENT
TYPES OF TRAINING THAT COME AT
THE QUESTION FROM DIFFERENT
DIRECTIONS SO WE MAKE THOSE
TRANSFORMATIVE ADVANCE AND OF
COURSE TO TAKE PEOPLE ALONG THE
JOURNEY.
SO HERE ARE A FEW PEOPLE WHO
HAVE BEEN REALLY PIVOTAL IN
HELPING WITH THE DIFFERENCE
RESEARCH THAT I'VE TALKED ABOUT
REALLY BRIEFLY TODAY AND THEN OF
COURSE, THE FUNDING AGENCIES OF
WHICH NONE OF THIS WOULD BE
POSSIBLE WITHOUT THEY SIP OR THE
A RO1 AND TWO THE AND WHICH
SUPPORTED MY FIRST KO8 AND IT'S
BEEN SUPPORTIVE OF ME ALL ALONG
AND TWO OF MY SCIENTIFIC
OFFICERS AND I WILL BE HAPPY TO
ANSWER ANY QUESTIONS.
>> THANK YOU, VERY MUCH, Dr.
JAMES AND SOMEHOW I CANNOT SEEM
TO TURN ON MY CAMERA.
THANK YOU, Dr. JAMES THAT
LECTURE WAS REALLY PIVOTING AND
EXCITING AND AND YOUR
EXPERIENCES AS A SCIENTIST IS
TRULY REMARKABLE BUT EVEN MORE
EXCITING WAS YOUR CAREER IS PATH
AND YOUR PASSION FOR YOUR WORK
IS ALSO VERY PALPABLE.
I HAVE THE ROLE OF MODERATING
THE Q&A AND SO FAR THEY HAVE
BEEN NON POSTED AND I'M SURE THE
AUDIENCE IS TRYING TO COMPOST
THEIR THOUGHTS AT THIS TIME AND
WHILE WE'RE WAITING TO HEAR FROM
THEM AND HOPEFULLY THIS TIME WE
GET BOTH CHATBOXES WHERE THEY
ARE POSITIONED, WE HAVE BEEN
ABLE TO SEE ONE OF THEM LAST
SESSION AND IT APPEARS THERE'S
ANOTHER ONE THAT WE DID NOT HAVE
ACCESS TO.
SO, Dr. JAMES, YOU WERE IN
LOCATE LA HOME A YOU SAY FIFTH
GENERATION AND GREW UP IN A FARM
BUT ENDED UP BEING A TOP-NOTCH
SCIENTIST AND PHYSICIAN.
IT APPEARS THAT YOU KNOW, YOU
WENT THROUGH THE DIFFERENT
CAREER DEVELOPMENTS MECHANISMS
AT NIH INCLUDING THE K AWARD AND
UP TO THE TIME YOU WERE A TENURE
PROFESSOR AND NOW YOU HAVE
MULTIPLE AWARDS AND STARTING
WITH THE R AND ENDING UP WITH
THIS VERY HUGE
MULTI-DISCIPLINARY,
MULTI-SECTORAL AND MULTI
INSTITUTIONAL BECAUSE IT IS NOT
JUST FOR INSTANCE FOR THE
AMP-AIM IT'S NOT JUST NAIMS OR
AWARD THE AGES.
NAIMS AND NIAID, ET CETERA,
NETS.
AT THE SAME TIME, YOU SAID THERE
ARE MANY RIGHT PATHS, WOULD YOU
SAY THAT BECAUSE IT SEEMS LIKE
YOU ARE A VERY GOOD POSTER CHILD
FOR THE NIH CAREER DEVELOPMENT
PATHWAY, WOULD YOU SAY THAT THIS
IS PROBABLY THE RIGHT PATH FOR
YOU?
>> OH, WITHOUT A DOUBT THIS WAS
THE RIGHT PATH FOR ME.
I THINK IT WAS PARTIALLY BECAUSE
I CAME FROM A BACKGROUND WHERE
NO ONE HAD THOUGHT ABOUT
SCIENCES AS A CAREER, RIGHT.
THE GREAT THING FOR ME THROUGH
MY F31 I SAW THE NIH HAD THESE
DIFFERENT STEPS AND HAD
INFORMATION ABOUT HOW TO
TRANSITION AT DIFFERENT CAREER
POINTS AND DIFFERENT TYPES OF
AWARDS AND SO I THINK THAT
BETWEEN THAT AND THEN TALK TO GO
MY PROGRAM OFFICERS THAT WERE
VERY TUNED INTO THOSE THINGS AND
HELPED ME FIND THAT CAREER PATH
AND I THINK WE DO HAVE ONE
QUESTION THAT I SEE IN THE CHAT
AND IT MAY BE THAT WE SEE
DIFFERENT CHATS AND IS ABOUT THE
FACT THAT SOMEONE NOTICED THAT
ALL OF MY MENTORS AND
INSTITUTIONAL LEADERS WERE ALL
WHITE MEN, ENGAGE MORE MALE
MENTORS AND LEADERS TO DEVELOP
NEXT GENERATION FEMALE
SCIENTISTS MENTORS AND LEADERS
AND THIS IS A GOOD QUESTION AND
SO I'VE ALWAYS BEEN IN OKLAHOMA
AND OKLAHOMA, EVEN KNOW, THE
NUMBER OF TEEN YOU'RED
PROFESSORS THAT WE HAVE THAT ARE
FULL FEMALE PROFESSOR IN THE
COLLEGE OF MEDICINE,
UNFORTUNATELY, IT'S STILL A
LITTLE BIT BELOW 20% WHICH IS
DRAMATICALLY LOWER THAN THE
NUMBER OF ASSISTANT PROFESSOR
WHO ARE ABOUT 55% WOMEN SO
THERE'S JUST NOT ENOUGH SENIOR
FEMALE MENTORS TO MENTOR THE
NEXT GENERATION AND SO, I POINT
DON CAPRA AND HE WAS AN OUT
STANDING MENTOR TO FEMALE
SCIENTISTS AND IN WHO ARE NOW RA
CROSS THE UNITED STATES AND
DOING GREAT SCIENCE AND I THINK
THAT HE CONTRIBUTED THIS TOO.
HE WAS MARRIED TO ANOTHER Dr.
CAPRA, HIS WIFE, WHO WAS A
FEMALE SCIENTIST WHO WAS A NURSE
SCIENTIST AND THE FACT THAT HE
REALLY WORKED VERY HARD TO MAKE
SURE THAT HE HE WAS PROVIDING
THE SAME OPPORTUNITIES, THE SAME
OPTIONS TO ALL OF HIS FACULTY
WHETHER THEY WERE MALE OR
FEMALE, WHETHER THEY WERE
HISTORICALLY FROM UNDERSERVED
BACKGROUNDS OR FROM PEOPLE WHO
CAME WITH THE PEDESTRIAN A GROW
OF FIVPEDIGREE OFSCIENTISTS, RIGHT SO I TH INK
THAT THAT WAS A GREAT ROLE MODEL
FOR ME TO HAVE AND I THINK THAT
TOO MANY OTHER MALE AND FEMALE
SCIENTISTS THAT HE HAS LEARNED
HE HAS PASSED THAT ON EAT LEAST
THROUGHOUT THE IMMUNOLOGY
COMMUNITY SO A LOT OF THAT CAN
HAPPEN AND I THINK THAT THERE
ARE MORE TOOLS NOW THAT ARE
AVAILABLE TO HELP INSTITUTIONS
TO HELP THAT HAPPEN.
I WAS JUST ACTUALLY, FOR
SOMETHING ELSE, READING THE
NATIONAL ACADEMY REPORT ON BEST
PRACTICES TO HELP FORWARD WOMEN
SCIENTISTS AND SCIENTISTS FROM
UNDER REPRESENTED AK GROUNDS AND
THERE ARE A LOT OF DIFFERENT
OPTIONS IN THERE AND I THINK
THAT HE ACTUALLY PROBABLY
THOUGHT OF SOME OF THOSE THINGS
BEFORE PEOPLE WERE STARTING TO
ACTUALLY DO RESEARCH AND LINE
THIS OUT.
>> THANK YOU.
AND THANK YOU ALSO FOR
EMPHASIZING MENTORSHIP AND
SPONSORSHIP AND MAY ALSO SAY
ALLY SHIP AND IT ECHOS THE
THOUGHTS THAT WERE DISCUSSED
DURING THE SUMMIT MEETING THAT
WE HAD THIS SPRING AND WHICH
ACTUALLY WAS SORT OF A WITH THE
AIM PROGRAM WHERE TEAM SCIENCE
AND DISCIPLINARY APPROACHES AS
WELL AS EMERSION AND
COLLABORATION ACROSS SECTORS
WHICH IS AN ABILITY FOR THE
AMP-AIM PROGRAM TO IMPLEMENT
BECAUSE OF THIS STRUCTURE AND
AGAIN I CAN'T EMPHASIZE HOW
LUCKY WE ARE THA THAT YOU WILL LEAD
THAT PROJECT.
>> WE'RE JUST SO EXCITED TO HAVE
THAT OPPORTUNITY AND IT'S SUCH
AN INCREDIBLE OPPORTUNITY FOR US
TO BRING IN FEMALE SCIENTIST
WHO'S ARE THINKING ABOUT COMMON COMMON
THEMES ACROSS DISEASE, PAIN,
FATIGUE, MENTAL FOG, THOSE
AFFECT MANY PATIENTS ACROSS OUR
DIFFERENT AUTO IMMUNE DISEASES
AND BECAUSE THE WAY AMP-AIM WAS
SET UP WE HAVE TEAMS THAT THINK
ABOUT THE DISEASE ENTITIES
INDIVIDUALLY AND SO WE WERE
REALLY HOPEFUL THAT WE WILL GET
SCIENTISTS THINKING ABOUT
COMPUTATIONAL METHODS LIKE
ACROSS ALL FOUR OR OTHER PATIENT
REPORTED OUTCOMES ACROSS ALL
FOUR DISEASES SO I'M HOPING
THERE ARE GREAT CANDIDATES
LISTENING TO THIS LECTURE TODAY.
>> THANK YOU.
WHILE THAT WAS FOCUSED ON MID
CAREER SCIENTISTS WHAT WE'RE
TRYING TO DO IS ACTUALLY DO A
PILOT WITH AMP-AIM AND EXPAND IT
IF THE OUTCOMES ARE VERY
PROMISING EVEN EARLIER OR LATER
THAN THAT IN THEIR CAREER
STAGES.
DO WE HAVE ANY OTHER QUESTIONS
ON THE CHAT?
I DON'T SEE ANY HERE.
THAT WERE FORWARDED TO ME.
AGAIN, I WOULD LIKE TO THANK YOU
VERY MUCH.
THIS IS BEEN AN ENLIGHTENING
TALK AND I WOULD LIKE TO GIVE
THE FLOOR BACK TO Dr. LISA
BEGG.
TO CLOSE OUR SESSIONS.
>> THANK YOU, Dr. TIGNO.
A PROFOUND THANK YOU TO Dr.
JAMES FOR A SUPER TALK AND I
LISTENED TO YOUR TALK BEFORE THE
MEETING AND THEN OF COURSE, THIS
TIME AND IT'S EVEN MORE POWERFUL
SO I ENCOURAGE EVERYONE TO KEEP
THIS BOOK MARKED AND IT WILL BE
ON THE NIH VIDEO CAST ARCHIVE
AND A FEW DAYS AND IT WILL ALSO
THE LINK WILL BE PLACED ON OUR
WEBSITE AND AS IT WILL FOR THE
RUTH L. KIRSCHSTEIN MEMORIAL
LECTURE SHIP IN THE GENERAL LINK
FOR THE MEETING AS WELL.
THANK YOU SO MUCH Dr. JAMES,
FOR YOUR LEADERSHIP AND YOUR
SUPERB ROLE MODEL FOR ALL OF US.
IT'S MUCH APPRECIATED.
>> THANK YOU.
>> AS WE COME TO THE END OF THE
PLENARY SELLING SESSION, IF I HAVE THE
SLIDE AND Dr. MAY TON MAY WANT
TO MAKE COMMENTS TOO SO JUST ONE
SORT OF APPARENTLY WE HAVE SOME
SORT OF A BUG IN SOME OF THESE
BEING ABLE TO POSE QUESTIONS SO,
IF THERE WERE ANY QUESTIONS FROM
THE MORNING OR EVEN UP UNTIL
NOW, AND YOU HAVE NOT BEEN ABLE
TO GET THROUGH, E-MAIL ME AND I
WILL SEE WHAT I CAN DO IN TERMS
OF GETTING YOU AN ANSWER.
I WOULD BE HAPPY TO DO THAT AND
WE'LL FIGURE THAT OUT.
A LITTLE PLUG FOR THE POSTER
SESSION, WHICH I'M GO TO GO INTO
THAT ALL THREE OF THEM WILL BE
PRESENT FOR THE POSTER SESSION
ICH BEGINS AT 2:30 AND GOES TO
4:00 AND IS VIEWABLE FOR THE
NEXT THREE MONTHS ON THE VIRTUAL
PLATFORM SO FOR THOSE OF YOU
THAT WANT TO GO, YOU SEE THE
LITTLE POSTER HOLE, THE RED BAR
AROUND IT AND IF YOU HIT THAT
THEN YOU COME INTO THE 51
ABSTRACTS AND THEY'RE GROUPED SO
YOU CAN PULL DOWN THE INDEX
THERE AND YOU WILL SEE WHICH ARE
CLINICAL, NEUROSCIENCE, SEX AND
GENDER AND SO ON AND SO FOURTH.
SO YOU CAN THEN GO IN AND THE
SEARCH BAR AND FIND THE SPECIFIC
ABSTRACT YOU WANT AND CONTACT
BETWEEN 2:30 AND 4:00 TODAY THE
LEAD AUTHOR FOR THE POSTER, THE
BIRCWH SCHOLAR.
SO WITH THAT, I TURN IT OVER TO
Dr. CLAYTON FOR ANY FINAL,
FINAL COMMENTS BUT AGAIN, THANK
YOU SO MUCH FOR YOUR INTEREST IN
OUR PROGRAM.
WE'RE PLEASED THAT WE HAVE HAD
ANOTHER SUCCESSFUL MEETING.
>> THANK YOU, Dr. BEGG.
I WANT TO ADD MY THANKS TO
EVERYONE, ALL OUR SPEAKERS,
SCHOLARS, P.I.s, CO P.I.s,
EVERYONE ATTENDING AND EVERYONE
THANK YOU VERY, VERY MUCH AND I
WANT TO END BY THANKING THE
AMAZING BIRCWH TEAM AND THAT
WOULD BE Dr. BEGG, Dr.
TIGNO, Dr. HUANG, Dr. JOHNS,
AND I THINK I GOT EVERYONE?
AND EVERYONE ON THE CAREER
SECTION.
THANK YOU TO OUR CONTRACTORS AND
OUR COMMUNICATION STAFF WHO DID
A LOT OF WORK BEHIND THE SCENES
TO MAKE THE MEETING GO SMOOTHLY
AND WE'LL SEE YOU IN THE POSTER
HALL, THANK YOU, EVERYONE.