1 00:00:10,355 --> 00:00:15,393 WOULD LIKE TO CALL TO ORDER THE 2 00:00:15,393 --> 00:00:19,164 MEETING AND I'M VIVIAN OTA WANG 3 00:00:19,164 --> 00:00:22,801 AND EXECUTIVE SECRETARY OF THIS 4 00:00:22,801 --> 00:00:23,368 COMMITTEE. 5 00:00:23,368 --> 00:00:26,371 MEETING IS OPEN TO THE PUBLIC 6 00:00:26,371 --> 00:00:29,241 VIA LIVE BROADCAST ON THE NIH 7 00:00:29,241 --> 00:00:31,910 VIDEO NETWORK AND AVAILABLE FOR 8 00:00:31,910 --> 00:00:33,612 FUTURE ON DEMAND VIEWING FOR THE 9 00:00:33,612 --> 00:00:33,845 PUBLIC. 10 00:00:33,845 --> 00:00:39,284 ONE NOTE FOR PEOPLE IN THE ROOM 11 00:00:39,284 --> 00:00:42,988 TODAY, THERE IS AN IRREGULARITY 12 00:00:42,988 --> 00:00:45,257 ON THE FLOOR WITH TAPE AND HAS 13 00:00:45,257 --> 00:00:46,691 AN INCLINE SO YOU DON'T TRIP. 14 00:00:46,691 --> 00:00:51,863 JUST WANTED TO BRING THAT TO 15 00:00:51,863 --> 00:00:53,098 YOUR ATTENTION. 16 00:00:53,098 --> 00:00:55,667 IF YOU'RE A MEMBER OF THE PUBLIC 17 00:00:55,667 --> 00:00:58,270 PER THE FEDERAL REGISTER NOTICE 18 00:00:58,270 --> 00:01:02,507 YOU MAY SUBMIT WRITING TO ME AND 19 00:01:02,507 --> 00:01:03,141 WE'LL ADDRESS YOUR QUESTIONS 20 00:01:03,141 --> 00:01:10,882 AFTER THE MEETING. 21 00:01:10,882 --> 00:01:11,883 THIS MEETING IS HYBRID AND 22 00:01:11,883 --> 00:01:13,718 ADVISORY MEMBERS ARE 23 00:01:13,718 --> 00:01:14,553 PARTICIPATING IN PERSON AND 24 00:01:14,553 --> 00:01:16,054 THROUGH ZOOM AND NOW A MESSAGE 25 00:01:16,054 --> 00:01:16,988 TO OUR MEMBERS. 26 00:01:16,988 --> 00:01:19,724 THIS IS BASICALLY A REMINDER 27 00:01:19,724 --> 00:01:22,227 THAT YOU ARE SPECIAL GOVERNMENT 28 00:01:22,227 --> 00:01:23,528 EMPLOYEES. 29 00:01:23,528 --> 00:01:25,530 AS MEMBERS OF THIS FEDERAL 30 00:01:25,530 --> 00:01:28,800 ADVISORY COMMITTEE YOUR SPECIAL 31 00:01:28,800 --> 00:01:29,935 GOVERNMENT EMPLOYEES WHICH MEANS 32 00:01:29,935 --> 00:01:31,236 YOUR SUBJECT TO THE SAME ETHICS 33 00:01:31,236 --> 00:01:34,072 RULE THAT APPLY TO GOVERNMENT 34 00:01:34,072 --> 00:01:35,907 EMPLOYEES AND THEY'RE TITLED 35 00:01:35,907 --> 00:01:37,609 STANDARD OF ETHICAL CONDUCT FOR 36 00:01:37,609 --> 00:01:38,910 EMPLOYEES OF THE EXECUTIVE 37 00:01:38,910 --> 00:01:39,144 BRANCH. 38 00:01:39,144 --> 00:01:40,579 YOU RECEIVED A COPY OF THIS 39 00:01:40,579 --> 00:01:42,447 DOCUMENT WHEN YOU WERE 40 00:01:42,447 --> 00:01:42,714 APPOINTED. 41 00:01:42,714 --> 00:01:45,851 AT EVERY MEETING, WE'D LIKE TO 42 00:01:45,851 --> 00:01:47,886 REVIEW THE STEPS 1:WE TAKE AND 43 00:01:47,886 --> 00:01:50,889 PROCESSES WE FOLLOW TO IDENTIFY 44 00:01:50,889 --> 00:01:52,724 AND ADDRESS ANY CONFLICT BETWEEN 45 00:01:52,724 --> 00:01:55,894 YOUR PRIVATE RESPONSIBILITIES 46 00:01:55,894 --> 00:01:56,661 AND PUBLIC INTERESTS. 47 00:01:56,661 --> 00:01:59,364 YOU PROVIDE US WITH A GREAT DEAL 48 00:01:59,364 --> 00:02:00,632 OF INFORMATION ABOUT YOUR 49 00:02:00,632 --> 00:02:01,233 PROFESSIONAL, PERSONAL AND 50 00:02:01,233 --> 00:02:02,200 FINANCIAL INTERESTS. 51 00:02:02,200 --> 00:02:06,438 WE USE THIS INFORMATION AS THE 52 00:02:06,438 --> 00:02:07,906 FOUNDATION FOR ASSESSING FOR 53 00:02:07,906 --> 00:02:09,040 WHETHER THERE'S REAL POTENTIAL 54 00:02:09,040 --> 00:02:10,342 OR APPARENT CONFLICTS OF 55 00:02:10,342 --> 00:02:11,910 INTEREST THAT COULD COMPROMISE 56 00:02:11,910 --> 00:02:15,981 YOUR ABILITY TO BE OBJECTIVE IN 57 00:02:15,981 --> 00:02:17,282 GIVING ADVICE. 58 00:02:17,282 --> 00:02:20,418 IF YOUR NEED FOR SERVICES 59 00:02:20,418 --> 00:02:22,287 OUTWEIGH THE CONFLICT OF 60 00:02:22,287 --> 00:02:24,389 INTERESTS IDENTIFIED WE WILL 61 00:02:24,389 --> 00:02:25,690 RECUSE YOU FROM A PARTICULAR 62 00:02:25,690 --> 00:02:28,226 PORTION OF THE MEETING. 63 00:02:28,226 --> 00:02:30,662 WE USUALLY WAIVE CONFLICTS OF 64 00:02:30,662 --> 00:02:31,796 INTERESTS BECAUSE WE BELIEVE 65 00:02:31,796 --> 00:02:32,797 YOUR ABILITY TO BE OBJECTIVE 66 00:02:32,797 --> 00:02:34,933 WILL NOT BE AFFECTED BY YOUR 67 00:02:34,933 --> 00:02:36,334 FINANCIAL INTERESTS AND RELY A 68 00:02:36,334 --> 00:02:37,202 GREAT DEAL ON YOU. 69 00:02:37,202 --> 00:02:39,771 YOU NEED TO BE ATTENTIVE DURING 70 00:02:39,771 --> 00:02:41,806 MEETING TO THE POSSIBILITY AN 71 00:02:41,806 --> 00:02:50,148 ISSUE COULD ARISE THAT COULD 72 00:02:50,148 --> 00:02:50,982 AFFECT YOUR RESPONSIBILITY AND 73 00:02:50,982 --> 00:02:53,418 YOU WILL BE ASKED TO RECUSE 74 00:02:53,418 --> 00:02:54,019 YOURSELF FROM THAT PORTION OF 75 00:02:54,019 --> 00:02:59,391 THE MEETING. 76 00:02:59,391 --> 00:03:01,927 BEFORE INTRODUCTIONS I'D LIKE TO 77 00:03:01,927 --> 00:03:03,895 REVIEW BEST PRACTICES FOR 78 00:03:03,895 --> 00:03:04,729 PARTICIPANTS IN THE HYBRID 79 00:03:04,729 --> 00:03:05,063 SETTING. 80 00:03:05,063 --> 00:03:07,565 PLEASE FOR ALL OF YOU, PLEASE 81 00:03:07,565 --> 00:03:09,367 MUTE YOUR MICROPHONES IF YOU'RE 82 00:03:09,367 --> 00:03:10,335 NOT SPEAK. 83 00:03:10,335 --> 00:03:12,037 WHEN SPEAKING, PLEASE STATE YOUR 84 00:03:12,037 --> 00:03:15,173 NAME BEFORE MAKING COMMENTS, 85 00:03:15,173 --> 00:03:15,573 MOTIONS OR RNGDS. 86 00:03:15,573 --> 00:03:17,042 -- RECOMMENDATIONS. 87 00:03:17,042 --> 00:03:19,444 IF IN PERSON, PLEASE MAKE SURE 88 00:03:19,444 --> 00:03:20,445 YOU'RE MICROPHONE IS ON WHILE 89 00:03:20,445 --> 00:03:23,114 SPEAK AND REFRAIN FROM DRAGGING 90 00:03:23,114 --> 00:03:25,450 THE MICROPHONE ACROSS THE TABLE 91 00:03:25,450 --> 00:03:29,087 AND PLEASE DO NOT LEAN BACK WHEN 92 00:03:29,087 --> 00:03:29,854 SPEAKING INTO THE MICROPHONE. 93 00:03:29,854 --> 00:03:32,991 IF ONLINE TRY TO USE A HEADSET 94 00:03:32,991 --> 00:03:35,593 WITH A MICROPHONE WHEN SPEAKING 95 00:03:35,593 --> 00:03:38,496 AND THAT IS THAT WILL USUALLY 96 00:03:38,496 --> 00:03:42,467 RESULT IN THE CLEAREST TONE AND 97 00:03:42,467 --> 00:03:43,935 LEAST AMOUNT OF FEEDBACK AND 98 00:03:43,935 --> 00:03:46,738 ENCOURAGE TO YOU TURN ON YOUR 99 00:03:46,738 --> 00:03:47,872 CAMERAS TO GET THE FULL VISUAL 100 00:03:47,872 --> 00:03:49,174 EXPERIENCE OF US BEING IN FULL 101 00:03:49,174 --> 00:03:49,441 COMMITTEE. 102 00:03:49,441 --> 00:03:50,408 IF YOU HAVE A QUESTION OR WOULD 103 00:03:50,408 --> 00:03:51,910 LIKE TO MAKE A COMMENT, PLEASE 104 00:03:51,910 --> 00:03:54,145 RAISE YOUR HAND. 105 00:03:54,145 --> 00:03:59,884 WHEN INDICATED, MEMBERS WILL 106 00:03:59,884 --> 00:04:02,520 RAISE THEIR HANDS AND WE'LL VOTE 107 00:04:02,520 --> 00:04:05,790 TO ACCEPT OR OBJECT OR REFRAIN 108 00:04:05,790 --> 00:04:08,393 SO RAISE YOUR HAND IN ACCORDANCE 109 00:04:08,393 --> 00:04:11,629 WITH YOUR RESPONSE AND WE'LL 110 00:04:11,629 --> 00:04:14,032 SHARE THE ZOOM GALLERY DURING 111 00:04:14,032 --> 00:04:15,333 THIS TIME TO SEE YOUR VOTE. 112 00:04:15,333 --> 00:04:17,469 AS I GO THROUGH THE ROSTER, WHEN 113 00:04:17,469 --> 00:04:19,838 YOU HEAR YOUR NAME, PLEASE 114 00:04:19,838 --> 00:04:21,573 UNMUTE YOUR MIC AND INTRODUCE 115 00:04:21,573 --> 00:04:25,710 YOURSELF BY NAME AND WHAT 116 00:04:25,710 --> 00:04:27,445 INSTITUTION YOU REPRESENT ALSO, 117 00:04:27,445 --> 00:04:29,414 IF YOU HAVEN'T ALREADY SIGN IN 118 00:04:29,414 --> 00:04:35,887 AT THE SHEET AT THE FRONT TABLE. 119 00:04:35,887 --> 00:04:37,655 DR. ANDERSON. 120 00:04:37,655 --> 00:04:38,023 >> GOOD MORNING. 121 00:04:38,023 --> 00:04:42,027 DR. ANDERSON REPRESENTING THE 122 00:04:42,027 --> 00:04:46,064 FRED HUSHINSON CANCER CENTER IN 123 00:04:46,064 --> 00:04:46,331 SEATTLE. 124 00:04:46,331 --> 00:04:50,035 >> DR. MILLANS. 125 00:04:50,035 --> 00:04:54,472 >> I'M FROM COLUMBIA UNIVERSITY 126 00:04:54,472 --> 00:04:56,574 MELMAN'S SCHOOL OF PUBLIC 127 00:04:56,574 --> 00:04:57,842 HEALTH. 128 00:04:57,842 --> 00:05:01,413 >> DR. UNYENYA. 129 00:05:01,413 --> 00:05:02,747 >> I'M FROM THE SOCIETY FOR 130 00:05:02,747 --> 00:05:06,017 WOMEN'S HEALTH RESEARCH. 131 00:05:06,017 --> 00:05:10,422 >> DR. HIGGINS. 132 00:05:19,864 --> 00:05:23,735 >> DR. CHATSI. 133 00:05:23,735 --> 00:05:27,172 >> THE CHAIR OF RADIATION 134 00:05:27,172 --> 00:05:27,439 ONCOLOGY. 135 00:05:27,439 --> 00:05:29,274 >> DR. JONES. 136 00:05:29,274 --> 00:05:32,477 >> I'M ANDREAENS AND I'M A 137 00:05:32,477 --> 00:05:33,912 PROFESSOR IN THE DEPARTMENT OF 138 00:05:33,912 --> 00:05:35,947 OBSTETRICS AND GYNECOLOGY AT THE 139 00:05:35,947 --> 00:05:37,682 UNIVERSITY OF NORTH CAROLINA 140 00:05:37,682 --> 00:05:39,918 CHAPEL HILL. 141 00:05:39,918 --> 00:05:43,888 >> DR. KNOWEL. 142 00:05:43,888 --> 00:05:44,022 143 00:05:44,022 --> 00:05:46,891 >> I'M AN ASSOCIATE PROFESSOR IN 144 00:05:46,891 --> 00:05:48,226 THE DEPARTMENT OF COMPARATIVE 145 00:05:48,226 --> 00:05:51,896 SCIENCES AT LOUISIANA STATE 146 00:05:51,896 --> 00:05:53,298 UNIVERSITY. 147 00:05:53,298 --> 00:05:59,170 >> DR. SADOVSKY. 148 00:05:59,170 --> 00:06:04,275 >> I'M FROM THE UNIVERSITY OF 149 00:06:04,275 --> 00:06:04,576 PITTSBURGH. 150 00:06:04,576 --> 00:06:06,044 >> DR. SHARPS. 151 00:06:06,044 --> 00:06:07,979 MAYBIAN LINE. 152 00:06:07,979 --> 00:06:11,516 -- MAYBE ONLINE. 153 00:06:11,516 --> 00:06:13,218 >> I'M PROFESSOR AT JOHNS 154 00:06:13,218 --> 00:06:13,818 HOPKINS UNIVERSITY SCHOOL OF 155 00:06:13,818 --> 00:06:15,220 NURSING. 156 00:06:15,220 --> 00:06:25,463 >> DR. SIMON. 157 00:06:26,097 --> 00:06:31,836 >> I'M MELISSA SIMON OB-GYN AT 158 00:06:31,836 --> 00:06:32,170 NORTHWESTERN. 159 00:06:32,170 --> 00:06:37,275 >> PLEASE JOIN US AT THE TABLE. 160 00:06:37,275 --> 00:06:39,811 >> DR. TEMPLETON. 161 00:06:39,811 --> 00:06:42,080 >> I'M FROM PROFESSOR OF 162 00:06:42,080 --> 00:06:43,515 ORTHOPEDIC SURGERY AND ASSOCIATE 163 00:06:43,515 --> 00:06:45,483 DEAN FOR CONTINUING MEDICAL 164 00:06:45,483 --> 00:06:47,886 EDUCATION AT THE KANSAS IN 165 00:06:47,886 --> 00:06:54,058 KANSAS CITY. 166 00:06:54,058 --> 00:06:57,729 >> DR. BRUEGL. 167 00:06:57,729 --> 00:06:58,563 NEXT SLIDE. 168 00:06:58,563 --> 00:07:00,598 I WANT TO ACKNOWLEDGE AND THANK 169 00:07:00,598 --> 00:07:01,866 OUR MEMBERS WHO WILL BE RETIRING 170 00:07:01,866 --> 00:07:05,136 FROM OUR IN THE COMING MONTHS. 171 00:07:05,136 --> 00:07:08,840 THESE MEMBERS HAVE EACH SERVED 172 00:07:08,840 --> 00:07:11,910 DILIGENTLY ON ACRWH THE PAST 173 00:07:11,910 --> 00:07:13,378 FOUR YEARS. 174 00:07:13,378 --> 00:07:17,115 THESE ARE DR. GOTMAN. 175 00:07:17,115 --> 00:07:22,654 DR. SADOVSKY AND DR. TEMPLETON. 176 00:07:22,654 --> 00:07:27,892 THANK YOU FOR YOUR SERVICE. 177 00:07:27,892 --> 00:07:30,595 I'D ALSO LIKE TO RECOGNIZE OUR 178 00:07:30,595 --> 00:07:31,729 PENDING MEMBERS. 179 00:07:31,729 --> 00:07:32,597 THEY'LL JOIN THE ADVISORY GROUP 180 00:07:32,597 --> 00:07:35,900 IN THE UPCOMING WEEKS PENDING 181 00:07:35,900 --> 00:07:38,536 THEIR CLEARANCE. 182 00:07:38,536 --> 00:07:43,908 THEY ARE AYUSH GIRI, DR 183 00:07:43,908 --> 00:07:52,617 DR. OTOTOKUN AND WHY FATIMA 184 00:07:52,617 --> 00:07:52,884 STANFORD. 185 00:07:52,884 --> 00:07:54,118 WE LOOK FORWARD TO WELCOMING 186 00:07:54,118 --> 00:07:56,821 THEM TO THE COMMITTEE. 187 00:07:56,821 --> 00:08:00,091 YOU WERE EACH SENT THE MINUTES 188 00:08:00,091 --> 00:08:02,994 FROM OCTOBER 18, 2023 FOR 189 00:08:02,994 --> 00:08:03,328 REVIEW. 190 00:08:03,328 --> 00:08:04,562 ONLY FULL MEMBERS MAY VOTE. 191 00:08:04,562 --> 00:08:07,131 SO IF YOU'RE NOT A MEMBER OF 192 00:08:07,131 --> 00:08:07,899 ACRWH, PLEASE RESTRAIN FROM 193 00:08:07,899 --> 00:08:16,241 VOTING. 194 00:08:16,241 --> 00:08:20,411 IS THERE A MOTION TO ACCEPT THE 195 00:08:20,411 --> 00:08:22,080 MINUTES AS WRITTEN? 196 00:08:22,080 --> 00:08:30,788 DR. SADOVSKY SUBMITTED THE 197 00:08:30,788 --> 00:08:34,292 MOTION. 198 00:08:34,292 --> 00:08:36,694 FOR ALL ACCEPTING, PLEASE RAISE 199 00:08:36,694 --> 00:08:37,562 YOUR HANDS NOW. 200 00:08:37,562 --> 00:08:48,106 CAN WE HAVE THE GALLERY TO SEE? 201 00:08:49,974 --> 00:08:50,975 FOR ALL OPPOSED RAISE YOUR HANDS 202 00:08:50,975 --> 00:08:56,614 NOW. 203 00:08:56,614 --> 00:08:58,483 ALL ABSTAINING, RAISE YOUR 204 00:08:58,483 --> 00:09:00,585 MANDZ. 205 00:09:00,585 --> 00:09:01,753 -- HAPPENED. 206 00:09:01,753 --> 00:09:02,887 ERIC, HAVE THE VOTES BEEN 207 00:09:02,887 --> 00:09:03,454 RECORDED? 208 00:09:03,454 --> 00:09:11,896 WHAT IS THE VOTE NUMBER? 209 00:09:11,896 --> 00:09:16,134 THANK YOU THE OCTOBER 2023 210 00:09:16,134 --> 00:09:23,508 MEETING MINUTES HAVE BEEN 211 00:09:23,508 --> 00:09:23,775 ACCEPTED. 212 00:09:23,775 --> 00:09:26,911 YOU WERE ALL SENT A DRAFT OF THE 213 00:09:26,911 --> 00:09:28,346 2024, 2028 DRAFT OF STRATEGIC 214 00:09:28,346 --> 00:09:29,047 PLAN TO REVIEW. 215 00:09:29,047 --> 00:09:31,683 I'D LIKE TO OPEN THE FLOOR FOR A 216 00:09:31,683 --> 00:09:35,920 FEW MINUTES FOR MEMBERS' 217 00:09:35,920 --> 00:09:44,829 COMMENTS ABOUT THE DRAFT. 218 00:09:44,829 --> 00:09:50,668 YES, DR. SIMON. 219 00:09:50,668 --> 00:09:52,704 >> I HAVE SEVERAL COMMENTS. 220 00:09:52,704 --> 00:09:54,505 UNTIL WHEN DO I HAVE TO SUBMIT? 221 00:09:54,505 --> 00:09:58,376 >> UNTIL THE END OF THE WEEK 222 00:09:58,376 --> 00:09:59,344 WOULD BE MINE. 223 00:09:59,344 --> 00:10:02,213 DOES ANYBODY HAVE ANYTHING TO 224 00:10:02,213 --> 00:10:02,914 SHARE. 225 00:10:02,914 --> 00:10:04,916 HELLO, DR. TEMPLETON. 226 00:10:04,916 --> 00:10:05,616 >> THANK YOU. 227 00:10:05,616 --> 00:10:07,085 THIS IS AMAZING PIECE OF WORK. 228 00:10:07,085 --> 00:10:10,588 I APPRECIATE THE OPPORTUNITY TO 229 00:10:10,588 --> 00:10:10,922 REVIEW THIS. 230 00:10:10,922 --> 00:10:12,857 I DID HAVE COMMENTS YESTERDAY 231 00:10:12,857 --> 00:10:14,459 AND TO SUMMARIZE TWO AREAS, ONE 232 00:10:14,459 --> 00:10:24,535 THE 233 00:10:50,461 --> 00:10:52,163 I TOTALLY SUPPORT THAT BUT WE TO 234 00:10:52,163 --> 00:10:54,432 THE WOMEN IN LATE CAREER ALSO 235 00:10:54,432 --> 00:10:55,833 DON'T GET SUPPORTED AND PROBABLY 236 00:10:55,833 --> 00:10:58,102 HAVE LESS SUPPORT THAN THOSE IN 237 00:10:58,102 --> 00:11:00,805 EARLY CAREER WOMEN AND MEN AND 238 00:11:00,805 --> 00:11:02,106 LATE CAREER TEND TO BECOME 239 00:11:02,106 --> 00:11:03,074 INVISIBLE WITHIN THEIR 240 00:11:03,074 --> 00:11:04,442 DEPARTMENTS AND INSTITUTIONS. 241 00:11:04,442 --> 00:11:06,244 THEY LOSE THAT SUPPORT JUST WHEN 242 00:11:06,244 --> 00:11:08,479 THEY SHOULD BE RISING TO 243 00:11:08,479 --> 00:11:09,447 LEADERSHIP POSITIONS. 244 00:11:09,447 --> 00:11:11,082 SO THAT WAS MY OTHER 245 00:11:11,082 --> 00:11:14,485 RECOMMENDATION AS WE LOOK AT 246 00:11:14,485 --> 00:11:15,219 SUPPORTING WOMEN'S CAREERS IN 247 00:11:15,219 --> 00:11:18,823 THE BIOMEDICAL AREAS IT NEEDS TO 248 00:11:18,823 --> 00:11:20,591 BE CAREER LONG NOT ONLY 249 00:11:20,591 --> 00:11:21,859 SPECIFICALLY FOR MID CAREER 250 00:11:21,859 --> 00:11:22,059 WOMEN. 251 00:11:22,059 --> 00:11:23,094 THANK YOU. 252 00:11:23,094 --> 00:11:33,404 >> THANK YOU ZECH. 253 00:11:34,138 --> 00:11:36,641 >> I SUGGEST UNDER THE ASPECT OF 254 00:11:36,641 --> 00:11:38,509 DATA SHARING MORE DATA ELEMENTS 255 00:11:38,509 --> 00:11:39,110 PARTICULARLY AROUND THE 256 00:11:39,110 --> 00:11:41,913 TRANSITION TIMES IN WOMEN THAT 257 00:11:41,913 --> 00:11:43,648 ARE UNDER DEVELOPED OR NOT 258 00:11:43,648 --> 00:11:45,216 STANDARDIZED SO FOR DATA SHARING 259 00:11:45,216 --> 00:11:47,018 WE WOULD HAVE THE BETTER 260 00:11:47,018 --> 00:11:49,020 OPPORTUNITIES TO POOL OUR DATA 261 00:11:49,020 --> 00:11:51,889 IF WE HAD COMMON DATA ELEMENTS. 262 00:11:51,889 --> 00:11:58,095 >> THANK YOU. 263 00:11:58,095 --> 00:12:01,399 >> I WANTED TO COMPLIMENT 264 00:12:01,399 --> 00:12:03,501 DR. TEMPLETON ON HER POINT AND 265 00:12:03,501 --> 00:12:04,402 IT HELPED ME UNDERSTAND ISSUES 266 00:12:04,402 --> 00:12:10,241 I'M SEEING IN OUR OWN DEPARTMENT 267 00:12:10,241 --> 00:12:20,551 AND NOT FAMILIAR. 268 00:12:21,919 --> 00:12:25,623 >> THANK YOU. 269 00:12:25,623 --> 00:12:30,862 ANYONE ELSE. 270 00:12:30,862 --> 00:12:34,232 >> UNDER ENGAGEMENT IN THE GOAL 271 00:12:34,232 --> 00:12:35,700 5 HAPPY TO SEE IN PRAGMATIC 272 00:12:35,700 --> 00:12:37,401 TRIALS AND WONDERED IF THAT 273 00:12:37,401 --> 00:12:39,504 COULD BE EXPANDED A LITTLE BIT 274 00:12:39,504 --> 00:12:43,074 MORE TO INCLUDE OTHER DESIGNS 275 00:12:43,074 --> 00:12:47,178 AND IMPLEMENTATION SCIENCE. 276 00:12:47,178 --> 00:12:50,281 LIKE HYBRID 1 AND 2 AND HAPPY TO 277 00:12:50,281 --> 00:12:52,350 SEE THAT BUT MAYBE A LITTLE 278 00:12:52,350 --> 00:12:53,150 EXPANSION THERE. 279 00:12:53,150 --> 00:12:57,655 >> THANK YOU. 280 00:12:57,655 --> 00:13:00,424 ANYONE ELSE? 281 00:13:00,424 --> 00:13:02,293 IS THERE A MOTION ON THE TABLE 282 00:13:02,293 --> 00:13:05,596 TO ACCEPT THE 2024, 2028 283 00:13:05,596 --> 00:13:09,500 STRATEGIC PLAN AS WRITTEN? 284 00:13:09,500 --> 00:13:12,637 DO I HEAR A SECOND? 285 00:13:12,637 --> 00:13:17,775 WE HAVE A COUPLE SECONDS. 286 00:13:17,775 --> 00:13:20,778 DR. ANINYE AND DR. ANDERSON. 287 00:13:20,778 --> 00:13:21,612 ALL ACCEPTING RAISE YOUR HANS 288 00:13:21,612 --> 00:13:23,147 NOW. 289 00:13:23,147 --> 00:13:23,714 -- HANDS NOW. 290 00:13:23,714 --> 00:13:25,750 THANK YOU. 291 00:13:25,750 --> 00:13:27,885 ALL OPPOSED IN THE MOTION PLEASE 292 00:13:27,885 --> 00:13:38,195 RAISE YOUR HANDS. 293 00:13:44,402 --> 00:13:46,904 ALL ABSTAINING RAISE YOUR HANDS. 294 00:13:46,904 --> 00:13:49,307 >> 10 IN FAVOR AND ONE 295 00:13:49,307 --> 00:13:49,607 ABSTAINING. 296 00:13:49,607 --> 00:13:50,908 >> THANK YOU. 297 00:13:50,908 --> 00:13:53,110 THE 2024-2028 STRATEGIC PLAN ON 298 00:13:53,110 --> 00:13:54,712 RESEARCH FOR THE HEALTH OF WOMEN 299 00:13:54,712 --> 00:13:59,283 HAS BEEN ACCEPTED WITH 11 VOTES 300 00:13:59,283 --> 00:14:01,852 AND ONE ABSTAINED. 301 00:14:01,852 --> 00:14:07,291 I WOULD NOW LIKE TO ACKNOWLEDGE 302 00:14:07,291 --> 00:14:10,962 DR. NORISI WHO WAS THE EXECUTIVE 303 00:14:10,962 --> 00:14:21,138 SECRETARY. 304 00:14:24,775 --> 00:14:27,912 AS YOU KNOW SHE HAS BEEN 305 00:14:27,912 --> 00:14:29,580 HOLDING THE FORT DOWN DURING 306 00:14:29,580 --> 00:14:33,117 COVID AND ORGANIZING THE 307 00:14:33,117 --> 00:14:34,151 IMPORTANT PATH OF THE WORK OF 308 00:14:34,151 --> 00:14:38,889 THIS GROUP. 309 00:14:38,889 --> 00:14:42,259 WHEN I JOINED THE OFFICE AND I 310 00:14:42,259 --> 00:14:46,764 WAS OVERWHELMED WHEN THEY SAID I 311 00:14:46,764 --> 00:14:49,367 HAD TO FOLLOW HER FOOTSTEPS SO 312 00:14:49,367 --> 00:14:52,069 JUST A SMALL TOKEN AND IT YOU 313 00:14:52,069 --> 00:14:53,304 FOR YOUR SERVICE AND A WAS 314 00:14:53,304 --> 00:14:54,605 TRYING TO FIND THE NORTH STAR 315 00:14:54,605 --> 00:14:56,907 YOU MADE TO PUT THE MEETING 316 00:14:56,907 --> 00:14:57,174 TOGETHER. 317 00:14:57,174 --> 00:15:07,351 THANK YOU. 318 00:15:14,025 --> 00:15:15,960 >> I SAID YOU ONLY DID IT FOR 319 00:15:15,960 --> 00:15:18,896 ONE YEAR. 320 00:15:18,896 --> 00:15:21,232 IT WAS A PLEASURE TO WORK WITH 321 00:15:21,232 --> 00:15:24,902 ALL OF YOU AND THE PREVIOUS 322 00:15:24,902 --> 00:15:26,103 MEMBERS AND YOU'RE JUST A GREAT 323 00:15:26,103 --> 00:15:28,205 GROUP AND WE RELY ON YOU SO 324 00:15:28,205 --> 00:15:28,439 HEAVILY. 325 00:15:28,439 --> 00:15:30,975 IT WAS AN HONOR AND PRIVILEGE TO 326 00:15:30,975 --> 00:15:32,543 SERVE IN THAT ROLE. 327 00:15:32,543 --> 00:15:38,049 THANK YOU AGAIN FOR 328 00:15:38,049 --> 00:15:38,716 ACKNOWLEDGING VIVIAN WILL BE 329 00:15:38,716 --> 00:15:39,383 BETTER THAN ME. 330 00:15:39,383 --> 00:15:41,352 >> I'M NOT SURE ABOUT THAT BUT 331 00:15:41,352 --> 00:15:51,529 THANK YOU. 332 00:15:53,831 --> 00:15:56,801 >> NOW I'D LIKE TO INTRODUCE 333 00:15:56,801 --> 00:16:07,144 DR. JANINE CLAYTON. 334 00:16:08,479 --> 00:16:10,948 >> GOOD MORNING EVERYONE. 335 00:16:10,948 --> 00:16:13,517 DELIGHTED TO BE WITH YOU ALL. 336 00:16:13,517 --> 00:16:16,554 I WANT TO ACKNOWLEDGE 337 00:16:16,554 --> 00:16:20,658 DR. CHRISWILL JOINED US AND 338 00:16:20,658 --> 00:16:21,358 SEVERAL I.C. DIRECTORS WILL BE 339 00:16:21,358 --> 00:16:22,927 IN AND OUT TODAY THANK YOU FOR 340 00:16:22,927 --> 00:16:23,360 JOINING, LINDSEY. 341 00:16:23,360 --> 00:16:27,765 WE APPRECIATE THAT. 342 00:16:27,765 --> 00:16:30,601 IT'S MY PLEASURE TO GIVE THIS 343 00:16:30,601 --> 00:16:31,769 DIRECTOR'S REPORT TWICE A YEAR 344 00:16:31,769 --> 00:16:35,339 TO SHARE UPDATES ON THE WORK 345 00:16:35,339 --> 00:16:36,440 OFFICE RESEARCH OF WOMEN'S 346 00:16:36,440 --> 00:16:37,808 HEALTH HAS DONE IN COLLABORATION 347 00:16:37,808 --> 00:16:40,444 WITH THE SEVEN INSTITUTES AND 348 00:16:40,444 --> 00:16:42,546 CENTERS AT NIH AND MULTIPLE 349 00:16:42,546 --> 00:16:43,114 OFFICES. 350 00:16:43,114 --> 00:16:46,584 I'LL GIVE AN ORWH AND NIH UPDATE 351 00:16:46,584 --> 00:16:47,952 AND POLICY AND SCIENTIFIC 352 00:16:47,952 --> 00:16:50,755 UPDATES AND UPDATE ON CAREERS 353 00:16:50,755 --> 00:16:52,523 AND THEN CLOSE. 354 00:16:52,523 --> 00:16:54,492 I BELIEVE THIS SECTION ENDS AT 355 00:16:54,492 --> 00:16:54,692 10:30. 356 00:16:54,692 --> 00:16:55,893 CONFIRM THAT IF YOU WOULD. 357 00:16:55,893 --> 00:16:59,063 THANK YOU. 358 00:16:59,063 --> 00:17:01,999 I DO LIKE TO ALWAYS BEGIN WITH 359 00:17:01,999 --> 00:17:02,199 DATA. 360 00:17:02,199 --> 00:17:04,769 WE ARE A DATA-DRIVEN 361 00:17:04,769 --> 00:17:05,102 ORGANIZATION. 362 00:17:05,102 --> 00:17:06,203 IT DRIVES EVERYTHING WE DO AND 363 00:17:06,203 --> 00:17:06,904 IS OUR WHY. 364 00:17:06,904 --> 00:17:09,406 WHAT WE HAVE SEEN IS THAT OVER 365 00:17:09,406 --> 00:17:12,276 THE LAST 20 YEARS WOMEN HAVE 366 00:17:12,276 --> 00:17:14,411 EXPERIENCED GREATER INCREASES IN 367 00:17:14,411 --> 00:17:15,980 ALCOHOL USE PROBLEMS THAN MEN. 368 00:17:15,980 --> 00:17:23,621 SO ON THE TOP LEFT YOU SEE 369 00:17:23,621 --> 00:17:27,491 PRE-COVID ALCOHOL INVOLVED 370 00:17:27,491 --> 00:17:30,761 SUICIDE INCREASED SIGNIFICANTLY 371 00:17:30,761 --> 00:17:34,064 FOR WOMEN AND ALSO FOR MEN AGE 372 00:17:34,064 --> 00:17:35,432 35 TO 64. 373 00:17:35,432 --> 00:17:35,966 THIS IS BEFORE THE COVID 374 00:17:35,966 --> 00:17:38,402 PANDEMIC. 375 00:17:38,402 --> 00:17:40,304 DURING THE PANDEMIC, THIS 376 00:17:40,304 --> 00:17:44,041 NATIONAL INSTITUTE ON ALCOHOL 377 00:17:44,041 --> 00:17:45,743 ABUSE AND ALCOHOLISM FUNDED 378 00:17:45,743 --> 00:17:48,579 STUDY SHOWED A REDUCTION IN THE 379 00:17:48,579 --> 00:17:50,848 AVERAGE NUMBER OF DRINKS PER DAY 380 00:17:50,848 --> 00:17:53,250 FOR MEN AND TO CHANGE OR SLIGHT 381 00:17:53,250 --> 00:17:55,486 INCREASE FOR WOMEN IN THE DOTTED 382 00:17:55,486 --> 00:17:57,922 LINE SHOWN ON THE RIGHT. 383 00:17:57,922 --> 00:18:01,926 BOTTOM LEFT, THIS IS CDC DATA, 384 00:18:01,926 --> 00:18:03,594 DEATHS DUE TO EXCESSIVE ALCOHOL 385 00:18:03,594 --> 00:18:06,230 USE, THE FIRST DATA POINT IS 386 00:18:06,230 --> 00:18:10,367 2016 TO 2017 TO 2020 TO 2021 AT 387 00:18:10,367 --> 00:18:13,404 THE PEAK OF THE PANDEMIC. 388 00:18:13,404 --> 00:18:17,141 AND YOU SEE A 35% INCREASE IN 389 00:18:17,141 --> 00:18:20,110 DEATHS RELATED TO EXCESSIVE 390 00:18:20,110 --> 00:18:23,514 ALCOHOL USE FOR FEMALES AND 391 00:18:23,514 --> 00:18:26,083 26.8% INCREASE FOR MALES. 392 00:18:26,083 --> 00:18:29,820 THE BOTTOM LINE IS TOGETHER MEN 393 00:18:29,820 --> 00:18:33,924 AND WOMEN HERE THIS RESULTS IN 394 00:18:33,924 --> 00:18:36,760 ALMOST 500 EXTRA DEATHS PER DAY 395 00:18:36,760 --> 00:18:39,296 RELATED TO EXCESSIVE ALCOHOL 396 00:18:39,296 --> 00:18:39,463 USE. 397 00:18:39,463 --> 00:18:40,397 CLEARLY A CHALLENGE AND ISSUE 398 00:18:40,397 --> 00:18:44,768 FOR OUR COUNTRY AND THE WORLD. 399 00:18:44,768 --> 00:18:48,005 AND I WANTED TO DEMONSTRATE 400 00:18:48,005 --> 00:18:53,711 THROUGH THIS DEPICTION OF SEX 401 00:18:53,711 --> 00:18:54,845 DISAGGREGATED DATA HOW IMPORTANT 402 00:18:54,845 --> 00:18:57,214 IT IS TO LOOK AT IT BY SEX TO 403 00:18:57,214 --> 00:18:59,216 BETTER UNDERSTAND AND TARGET OUR 404 00:18:59,216 --> 00:18:59,984 INTERVENTIONS AND PREVENTION 405 00:18:59,984 --> 00:19:09,293 STRATEGIES APPROPRIATELY. 406 00:19:09,293 --> 00:19:13,898 I ALWAYS UPDATE YOU ON 407 00:19:13,898 --> 00:19:16,300 LEADERSHIP CHANGES AND IT'S MY 408 00:19:16,300 --> 00:19:19,904 PRIVILEGE TO INTRODUCE DR 409 00:19:19,904 --> 00:19:23,407 DR. SHANMUGAM IS HERE AND WE 410 00:19:23,407 --> 00:19:27,311 WELCOME YOU AND COMES TO US FROM 411 00:19:27,311 --> 00:19:28,345 MOST RECENTLY GEORGE WASHINGTON 412 00:19:28,345 --> 00:19:29,813 UNIVERSITY AND HAS A 413 00:19:29,813 --> 00:19:32,783 DISTINGUISHED CAREER IN 414 00:19:32,783 --> 00:19:35,319 RHEUMATOLOGY AND HAS BEEN AN NIH 415 00:19:35,319 --> 00:19:38,923 FUNDED INVESTIGATOR AND ONE AREA 416 00:19:38,923 --> 00:19:49,466 OF EMPHASIS HAS BEEN ON SCLE 417 00:19:50,668 --> 00:19:51,402 SCLERODERMA AND PLEASED TO HAVE 418 00:19:51,402 --> 00:19:54,438 YOU YOU ON BOARD AND WE 419 00:19:54,438 --> 00:19:55,973 INTRODUCED ELIZABETH BARR FOR 420 00:19:55,973 --> 00:19:58,342 THE INTERDISCIPLINARY RESEARCH 421 00:19:58,342 --> 00:20:00,544 SECTION AND SHE'S HERE IN THE 422 00:20:00,544 --> 00:20:01,078 GALLERY WAVING. 423 00:20:01,078 --> 00:20:03,247 WE'RE EXCITED TO WELCOME 424 00:20:03,247 --> 00:20:04,949 DR. BARR IN THIS ROLE. 425 00:20:04,949 --> 00:20:07,618 THESE BEEN A RESEARCH PROGRAM 426 00:20:07,618 --> 00:20:10,354 OFFICER IN THE ORWH SECTION AND 427 00:20:10,354 --> 00:20:12,723 HAD A Ph.D. FROM THE UNIVERSITY 428 00:20:12,723 --> 00:20:17,328 OF WISCONSIN-MADISON AND AT THE 429 00:20:17,328 --> 00:20:18,896 UNIVERSITY OF BALTIMORE COUNTY 430 00:20:18,896 --> 00:20:21,432 WORKING ON IN THE DISCIPLINARY 431 00:20:21,432 --> 00:20:22,633 CROSS-SECTOR PROJECTS TO 432 00:20:22,633 --> 00:20:24,134 INCREASE WOMEN'S ENGAGEMENT IN 433 00:20:24,134 --> 00:20:27,905 CHIN CKCAL -- CLINICAL RESEARCH 434 00:20:27,905 --> 00:20:29,974 AND HAS BEEN A LEADER IN THE HIV 435 00:20:29,974 --> 00:20:31,775 FIELD AND WOMEN. 436 00:20:31,775 --> 00:20:35,379 WELCOME TO OUR SENIOR LEADERSHIP 437 00:20:35,379 --> 00:20:36,647 TEAM. 438 00:20:36,647 --> 00:20:38,615 I'D LIKE TO PROVIDE THE 439 00:20:38,615 --> 00:20:39,917 LEADERSHIP CHANGES THAT OCCURRED 440 00:20:39,917 --> 00:20:41,185 SINCE WE LAST MET. 441 00:20:41,185 --> 00:20:44,321 DR. SCHWETZ IS NOW THE NIH 442 00:20:44,321 --> 00:20:46,123 DEPUTY DIRECTOR FOR PLANNING AND 443 00:20:46,123 --> 00:20:47,524 STRATEGIC INITIATIVES AND WILL 444 00:20:47,524 --> 00:20:50,594 BE JOINING US LATER TO GET TO 445 00:20:50,594 --> 00:20:51,161 MEET HER. 446 00:20:51,161 --> 00:20:56,867 DR. RATHMELL HAS BEEN NAMED THE 447 00:20:56,867 --> 00:20:58,202 DIRECTOR OF THE NATIONAL CANCER 448 00:20:58,202 --> 00:21:08,746 INSTITUTE AND ACTING DIRECTOR OF 449 00:21:11,615 --> 00:21:13,884 THE NATIONAL INSTITUTE OF MENTAL 450 00:21:13,884 --> 00:21:16,086 HEALTH WITH DR. JOSH GORDON'S 451 00:21:16,086 --> 00:21:19,857 ANNOUNCEMENT OF HIS DEPARTURE. 452 00:21:19,857 --> 00:21:23,861 AT THE LAST MEETING I INTRODUCED 453 00:21:23,861 --> 00:21:25,462 DR. BERTAGNOLLI TO YOU AND HAS 454 00:21:25,462 --> 00:21:27,898 HIT THE GROUND RUNNING AND 455 00:21:27,898 --> 00:21:29,833 SELECTED SEX DIFFERENCE AS A 456 00:21:29,833 --> 00:21:32,236 TOPIC FOR HER TWO BLOGS SO FAR 457 00:21:32,236 --> 00:21:36,540 AND HAS HAD MULTIPLE BLOGS AND 458 00:21:36,540 --> 00:21:38,342 WE'RE EXCITED AND AT LEAST TWO 459 00:21:38,342 --> 00:21:40,277 OF 15 HAVE BEEN FOCUSSED ON 460 00:21:40,277 --> 00:21:41,345 RELEVANCE TO WOMEN'S HEALTH AND 461 00:21:41,345 --> 00:21:46,250 SEX DIFFERENCES. 462 00:21:46,250 --> 00:21:55,426 WE NOW HAVE WE HAVE WOMEN I.C. 463 00:21:55,426 --> 00:21:56,326 DIRECTS AN IT'S IMPORTANT TO 464 00:21:56,326 --> 00:21:57,828 NOTE AS WE GROW OUR LEADERSHIP 465 00:21:57,828 --> 00:22:00,264 HERE AND AROUND THE COUNTRY. 466 00:22:00,264 --> 00:22:04,701 ADDITIONAL LEADERSHIP UPDATES, 467 00:22:04,701 --> 00:22:08,839 DR. FINZE IS ACTING AND 468 00:22:08,839 --> 00:22:14,044 DR. PASIAKOS IS IN OFFICE OF 469 00:22:14,044 --> 00:22:17,414 SUPPLEMENTS AND DR. BRENNER A 470 00:22:17,414 --> 00:22:20,884 NEW OFFICE WITHIN THE DIVISION 471 00:22:20,884 --> 00:22:23,854 OF PROGRAMMING AND STRATEGIC 472 00:22:23,854 --> 00:22:25,456 INITIATIVES AND DR. JORGENSON 473 00:22:25,456 --> 00:22:26,757 HAS BEEN NAMED THE NIH ASSOCIATE 474 00:22:26,757 --> 00:22:28,425 DIRECTOR FOR SCIENCE POLICY AND 475 00:22:28,425 --> 00:22:30,027 THE DIRECTOR OF THE NIH OFFICE 476 00:22:30,027 --> 00:22:30,661 OF SCIENCE POLICY. 477 00:22:30,661 --> 00:22:32,362 AND WE WELCOME THEM ALL AND LOOK 478 00:22:32,362 --> 00:22:35,432 FORWARD TO WORKING WITH THEM 479 00:22:35,432 --> 00:22:38,102 ALL. 480 00:22:38,102 --> 00:22:39,536 OTHER NEWS ACROSS NIH I'M 481 00:22:39,536 --> 00:22:43,474 EXCITED TO SHARE THERE'S A NEW 482 00:22:43,474 --> 00:22:45,309 RCDC CATEGORY FOR MENOPAUSE 483 00:22:45,309 --> 00:22:45,576 RESEARCH. 484 00:22:45,576 --> 00:22:49,246 THAT THIS WILL ALLOW US TO TRACK 485 00:22:49,246 --> 00:22:51,048 MENOPAUSE AND EXPORT 486 00:22:51,048 --> 00:22:52,916 EXPENDITURES RELATED TO 487 00:22:52,916 --> 00:22:54,418 MENOPAUSE TRANSPARENTLY TO THE 488 00:22:54,418 --> 00:22:54,952 PUBLIC. 489 00:22:54,952 --> 00:22:59,156 THERE'S A VARIETY OF OTHER RCDC 490 00:22:59,156 --> 00:23:01,125 TERMS ON THE SLIDE AND I WANT TO 491 00:23:01,125 --> 00:23:02,860 DRAW YOUR ATTENTION TO HEALTH 492 00:23:02,860 --> 00:23:05,229 DISPARITIES AND RACIAL OR ETHNIC 493 00:23:05,229 --> 00:23:06,964 MINORITY HEALTH RESEARCH, HEALTH 494 00:23:06,964 --> 00:23:07,898 DISPARITIES RESEARCH AS A 495 00:23:07,898 --> 00:23:09,800 SEPARATE CATEGORY AND RACIAL AND 496 00:23:09,800 --> 00:23:11,101 ETHNIC MINORITY HEALTH RESEARCH 497 00:23:11,101 --> 00:23:14,238 AS A SEPARATE CATEGORY AND 498 00:23:14,238 --> 00:23:15,672 DELINEATED FURTHER IS WORKFORCE 499 00:23:15,672 --> 00:23:17,774 DIVERSITY AND OUTREACH AS WELL 500 00:23:17,774 --> 00:23:19,743 AS BUILDING RESEARCH CAPACITY. 501 00:23:19,743 --> 00:23:21,745 SO THIS WILL PROVIDE ADDITIONAL 502 00:23:21,745 --> 00:23:23,447 GRANULARITY AND TRANSPARENCY TO 503 00:23:23,447 --> 00:23:25,582 OUR REPORTING. 504 00:23:25,582 --> 00:23:26,750 YOU'VE HEARD ABOUT THE NIH 505 00:23:26,750 --> 00:23:30,554 COMMUNITY PARTNERSHIPS TO 506 00:23:30,554 --> 00:23:31,889 ADVANCE SCIENCE FOR SOCIETY OR 507 00:23:31,889 --> 00:23:32,856 COMPASS PROGRAM. 508 00:23:32,856 --> 00:23:33,991 IT'S BEEN MY PLEASURE TO SERVE 509 00:23:33,991 --> 00:23:36,960 AS CO-CHAIR ON THIS GROUP. 510 00:23:36,960 --> 00:23:37,594 THIS IS A COMMON FUND PROGRAM 511 00:23:37,594 --> 00:23:38,428 AND I HAVE UPDATES FOR YOU 512 00:23:38,428 --> 00:23:40,264 TODAY. 513 00:23:40,264 --> 00:23:43,634 THE PURPOSE OF THE PROGRAM IS TO 514 00:23:43,634 --> 00:23:47,104 CATALYZE, DEPLOY AND EVALUATE 515 00:23:47,104 --> 00:23:48,772 COMMUNITY-LED HEALTH EQUITY 516 00:23:48,772 --> 00:23:49,940 STRUCTURAL INTERVENTION LEVERAGE 517 00:23:49,940 --> 00:23:51,742 PARTNERSHIPS ACROSS SECTORS. 518 00:23:51,742 --> 00:23:54,178 IN ADDITION, A SECONDARY GOAL IS 519 00:23:54,178 --> 00:23:56,613 TO DEVELOP A NEW HEALTH EQUITY 520 00:23:56,613 --> 00:24:01,552 RESEARCH MODEL FOR THIS 521 00:24:01,552 --> 00:24:02,586 COMMUNITY-LED MULTI-STRUCTURAL 522 00:24:02,586 --> 00:24:03,987 RESEARCH FOR NIH AND OTHER 523 00:24:03,987 --> 00:24:04,555 FEDERAL AGENCY. 524 00:24:04,555 --> 00:24:07,858 THE PROGRAM DURATION IS SET AT 525 00:24:07,858 --> 00:24:10,327 10 YEARS WITH AN APPROXIMATE 526 00:24:10,327 --> 00:24:12,129 BUDGET OF $10 MILLION FOR THE 527 00:24:12,129 --> 00:24:13,630 FIRST FIVE YEARS. 528 00:24:13,630 --> 00:24:15,666 AS YOU MIGHT RECALL COMPASS HAS 529 00:24:15,666 --> 00:24:16,900 THREE COMPONENTS. 530 00:24:16,900 --> 00:24:20,604 THE FIRST IS COMMUNITY-LEAD 531 00:24:20,604 --> 00:24:23,040 STRUCTURAL INTERVENTIONS AND 25 532 00:24:23,040 --> 00:24:24,441 AWARDS WERE MADE IN 2023. 533 00:24:24,441 --> 00:24:29,913 THE SECOND THE COMPASS 534 00:24:29,913 --> 00:24:31,181 COORDINATING CENTER AND THE 535 00:24:31,181 --> 00:24:33,717 THIRD IS THE HEALTH EQUITY 536 00:24:33,717 --> 00:24:34,985 RESEARCH HUB COMPONENT AND WE 537 00:24:34,985 --> 00:24:36,653 EXPECT UP TO FIVE AWARDS IN 538 00:24:36,653 --> 00:24:42,526 2024. 539 00:24:42,526 --> 00:24:44,528 THE COMMUNITY-LED INTERVENTIONS 540 00:24:44,528 --> 00:24:47,431 ADDRESS FIVE DIFFERENT TYPES OF 541 00:24:47,431 --> 00:24:48,832 STRUCTURAL FACTORS, COMMUNITY 542 00:24:48,832 --> 00:24:51,335 HEALTH CARE, SOCIAL AND CULTURAL 543 00:24:51,335 --> 00:24:52,502 CONTEXT, NEIGHBORHOOD AND BUILT 544 00:24:52,502 --> 00:24:53,637 ENVIRONMENT AND ECONOMIC 545 00:24:53,637 --> 00:24:55,205 DEVELOPMENT OR NUTRITION AND 546 00:24:55,205 --> 00:24:56,139 FOOD ENVIRONMENTS. 547 00:24:56,139 --> 00:24:58,141 AND I'M GOING TO GIVE YOU A 548 00:24:58,141 --> 00:24:59,309 HIGHLIGHT OF THREE OF THE 549 00:24:59,309 --> 00:25:02,279 CHESSIS AND LOOK FORWARD TO 550 00:25:02,279 --> 00:25:04,281 UPDATING YOU MORE IN THE FUTURE. 551 00:25:04,281 --> 00:25:06,250 THE FIRST IS THE PARTNERSHIP TO 552 00:25:06,250 --> 00:25:08,285 OPTIMIZE WOMEN'S EQUITY AND 553 00:25:08,285 --> 00:25:10,120 MATERNAL AND INFANT HEALTH. 554 00:25:10,120 --> 00:25:11,421 THESE ARE COMMUNITY 555 00:25:11,421 --> 00:25:12,756 ORGANIZATIONS RECEIVING THESE 556 00:25:12,756 --> 00:25:15,626 AWARDS AS DELTA HEALTH ALLIANCE. 557 00:25:15,626 --> 00:25:17,661 THAT'S PARTNERING WITH WESLEY 558 00:25:17,661 --> 00:25:20,664 JAMES AND JONATHAN BENNETTE AT 559 00:25:20,664 --> 00:25:21,932 THE UNIVERSITY OF MEMPHIS. 560 00:25:21,932 --> 00:25:23,634 THIS INVESTIGATOR AND GROUP IS 561 00:25:23,634 --> 00:25:24,968 LOOKING AT MISSISSIPPI'S BIRTH 562 00:25:24,968 --> 00:25:26,570 AND MATERNAL HEALTH DISPARITIES 563 00:25:26,570 --> 00:25:28,505 BY PROVIDING INFORMATION AND 564 00:25:28,505 --> 00:25:32,009 CARE FOR PARTICIPANTS FROM THE 565 00:25:32,009 --> 00:25:33,577 PRE-PREGNANCY PHASE TO 566 00:25:33,577 --> 00:25:35,579 POSTPARTUM IN RURAL AND 567 00:25:35,579 --> 00:25:37,080 LOW-INCOME SETTINGS. 568 00:25:37,080 --> 00:25:38,715 TRAINING IS PROVIDED TO 569 00:25:38,715 --> 00:25:39,850 CLINICIANS TO BETTER TAILOR 570 00:25:39,850 --> 00:25:41,818 RECOMMENDATIONS TO FIT THE NEEDS 571 00:25:41,818 --> 00:25:43,854 OF PATIENTS AS WELL AS 572 00:25:43,854 --> 00:25:45,022 ADDRESSING ECONOMIC STABILITY 573 00:25:45,022 --> 00:25:47,557 THROUGH IMPLEMENTING A MATERNAL 574 00:25:47,557 --> 00:25:51,194 LEAVE STIPEND AS A STRUCK 575 00:25:51,194 --> 00:25:51,528 INTERVENTION. 576 00:25:51,528 --> 00:25:53,930 THE HUMANITARIAN HEALTH CARE 577 00:25:53,930 --> 00:25:58,101 NETWORK BRINGING THE MOST 578 00:25:58,101 --> 00:26:04,207 VULNERABLE TO CARE LED BY 579 00:26:04,207 --> 00:26:05,475 LADIANA GARCIA IN SOUTHERN TEXAS 580 00:26:05,475 --> 00:26:07,744 AND LOOKS AT WAYS TO PROVIDE 581 00:26:07,744 --> 00:26:09,146 MEDICAL CARE FOR HIGH-RISK 582 00:26:09,146 --> 00:26:12,983 CHILDREN AND LATE-TERM PREGNANCY 583 00:26:12,983 --> 00:26:15,152 MOTHERS ALONG THE SOUTHERN 584 00:26:15,152 --> 00:26:16,953 BORDER OF TEXAS AND CONNECTING 585 00:26:16,953 --> 00:26:18,655 THEM TO MANAGEMENT INCLUDING 586 00:26:18,655 --> 00:26:20,691 CASE WORKERS AND CULTURALLY 587 00:26:20,691 --> 00:26:22,392 PROFICIENT PATIENT NAVIGATORS 588 00:26:22,392 --> 00:26:23,894 AND THE PHYSICIANS AND CARE 589 00:26:23,894 --> 00:26:24,761 PROVIDERS. 590 00:26:24,761 --> 00:26:26,496 THE THIRD IS THE PUERTO RICO 591 00:26:26,496 --> 00:26:29,933 COLLABORATIVE ADVANCEMENT OF 592 00:26:29,933 --> 00:26:33,170 RESEARCH, INNOVATIONS AND BEST 593 00:26:33,170 --> 00:26:35,405 PRACTICES FOR YOUTH AND 594 00:26:35,405 --> 00:26:35,672 FAMILIES. 595 00:26:35,672 --> 00:26:37,207 THIS IS LED BY A RESEARCH 596 00:26:37,207 --> 00:26:41,011 PARTNER AT THE UNIVERSITY OF 597 00:26:41,011 --> 00:26:44,147 PUERTO RICO AND GROUPO NEXOS 598 00:26:44,147 --> 00:26:46,016 LOOKING AT THE JUSTICE SYSTEM 599 00:26:46,016 --> 00:26:47,150 AND HEALTH CARE ACCESS AND 600 00:26:47,150 --> 00:26:47,984 EDUCATION AND ECONOMIC AND 601 00:26:47,984 --> 00:26:49,252 COMMUNITY DEVELOPMENT. 602 00:26:49,252 --> 00:26:52,823 AND THIS PROJECT IS AIMING TO 603 00:26:52,823 --> 00:26:55,392 REDUCE HEALTH DISPARITIES BY 604 00:26:55,392 --> 00:26:58,628 LOOKING AT CHILD POVERTY AND A 605 00:26:58,628 --> 00:27:00,764 MULTI-LEVEL INITIATIVE AND 606 00:27:00,764 --> 00:27:03,200 ADDRESSING A VARIETY OF AREAS 607 00:27:03,200 --> 00:27:04,768 INCLUDING QUALITY OF LIFE 608 00:27:04,768 --> 00:27:06,136 MEASURES AND THIS ADDRESSES 609 00:27:06,136 --> 00:27:09,005 THREE OF THE STRUCTURAL DOMAINS 610 00:27:09,005 --> 00:27:11,575 IDENTIFIED AS PART OF THE 611 00:27:11,575 --> 00:27:13,844 COMPASS PROGRAM. 612 00:27:13,844 --> 00:27:15,212 I'D LIKE TO PROVIDE YOU WITH 613 00:27:15,212 --> 00:27:21,952 POLICY AND SCIENTIFIC UPDATES. 614 00:27:21,952 --> 00:27:24,788 IT'S MY PLEASURE TO SHARE THE 615 00:27:24,788 --> 00:27:26,523 NEWS WITH YOU PRESIDENT JOE 616 00:27:26,523 --> 00:27:30,060 BIDEN AND THE FIRST LADY 617 00:27:30,060 --> 00:27:31,294 ANNOUNCED THE FIRST EVER FULL 618 00:27:31,294 --> 00:27:32,329 WHITE HOUSE INITIATIVE ON 619 00:27:32,329 --> 00:27:33,330 WOMEN'S HEALTH RESEARCH. 620 00:27:33,330 --> 00:27:36,333 I WAS EXCITED AND HONORED TO BE 621 00:27:36,333 --> 00:27:39,903 THERE WITH DR. BERTAGNOLLI WHEN 622 00:27:39,903 --> 00:27:42,105 THE PRESIDENT SIGNED THE 623 00:27:42,105 --> 00:27:43,340 PRESIDENTIAL MEMO TO ANNOUNCE 624 00:27:43,340 --> 00:27:45,108 THE EFFORT AND CHALLENGE 625 00:27:45,108 --> 00:27:45,909 EXECUTIVE AGENCIES AND PARTS OF 626 00:27:45,909 --> 00:27:48,278 THE WHITE HOUSE TO COME UP WITH 627 00:27:48,278 --> 00:27:50,380 RECOMMENDATIONS ON TANGIBLE 628 00:27:50,380 --> 00:27:51,715 ACTIONS THAT THE U.S. GOVERNMENT 629 00:27:51,715 --> 00:27:52,849 COULD TAKE TO ADVANCE WOMEN'S 630 00:27:52,849 --> 00:27:54,651 HEALTH RESEARCH. 631 00:27:54,651 --> 00:27:57,687 WE HAD TO COME UP WITH CONCRETE 632 00:27:57,687 --> 00:27:59,790 RECOMMENDATIONS WITHIN 45 DAYS, 633 00:27:59,790 --> 00:28:04,628 WHICH WE DID, TAKING A TARGETED 634 00:28:04,628 --> 00:28:06,229 APPROACH TO ENGAGE MULTIPLE 635 00:28:06,229 --> 00:28:16,740 SECTORS AND DRIVE INNOVATION. 636 00:28:17,607 --> 00:28:21,144 THEN IN MARCH AND I WAS WITH TO 637 00:28:21,144 --> 00:28:24,981 THE VICE PRESIDENT AND SECOND 638 00:28:24,981 --> 00:28:26,383 GENTLEMAN WHERE EXECUTIVE ORDER 639 00:28:26,383 --> 00:28:27,818 WAS SIGNED TO ADVANCE WOMEN'S 640 00:28:27,818 --> 00:28:29,386 HEALTH RESEARCH AND INNOVATION. 641 00:28:29,386 --> 00:28:31,855 THE KEY POINTS RELATED TO THIS 642 00:28:31,855 --> 00:28:33,924 ARE PRIORITIZING INVESTMENTS IN 643 00:28:33,924 --> 00:28:35,892 WOMEN'S HEALTH RESEARCH, 644 00:28:35,892 --> 00:28:37,594 INTEGRATING WOMEN'S HEALTH 645 00:28:37,594 --> 00:28:38,628 ACROSS THE FEDERAL RESEARCH 646 00:28:38,628 --> 00:28:43,800 PORTFOLIO, THIS IS MULTIPLE 647 00:28:43,800 --> 00:28:48,872 AGENCIES ACROSS THE GOVERNMENT 648 00:28:48,872 --> 00:28:51,675 AND ASSESSING UNMET NEEDS FOR 649 00:28:51,675 --> 00:28:55,846 WOMEN'S HEALTH RESEARCH AND 650 00:28:55,846 --> 00:28:59,049 YOU'LL HEAR FROM THE CHAIR OF 651 00:28:59,049 --> 00:29:00,650 THE INITIATIVE AND SHE'LL 652 00:29:00,650 --> 00:29:03,220 DELINEATE DETAILS SO I'M SURE 653 00:29:03,220 --> 00:29:08,758 WE'LL HAVE ROBUST DISCUSSION 654 00:29:08,758 --> 00:29:08,959 LATER. 655 00:29:08,959 --> 00:29:11,761 THE FIRST LADY VISITED MOREHOUSE 656 00:29:11,761 --> 00:29:14,731 SCHOOL OF MEDICINE AND THE CEO 657 00:29:14,731 --> 00:29:15,966 OF MOREHOUSE IS FEATURED HERE 658 00:29:15,966 --> 00:29:20,971 AND IS A FORMER ADVISORY MEMBER 659 00:29:20,971 --> 00:29:23,240 AND THE FIRST LADY SAID, QUOTE, 660 00:29:23,240 --> 00:29:27,110 WE HAVE A CLARE GOAL TO 661 00:29:27,110 --> 00:29:29,346 FUNDAMENTALLY CHANGE OUR NATION 662 00:29:29,346 --> 00:29:30,247 APPROACHES AND FUND WOMEN'S 663 00:29:30,247 --> 00:29:31,081 HEALTH RESEARCH. 664 00:29:31,081 --> 00:29:31,948 THERE ARE BIG GAPS IN RESEARCH 665 00:29:31,948 --> 00:29:36,920 ON DISEASES AND CONDITIONS THAT 666 00:29:36,920 --> 00:29:38,588 ONLY AFFECT WOMEN THAT 667 00:29:38,588 --> 00:29:39,356 DISPROPORTIONATELY AFFECT WOMEN 668 00:29:39,356 --> 00:29:40,590 OR AFFECT WOMEN AND MEN 669 00:29:40,590 --> 00:29:41,758 DIFFERENTLY, END QUOTE. 670 00:29:41,758 --> 00:29:43,927 I WAS EQUALLY HONORED TO JOIN 671 00:29:43,927 --> 00:29:46,496 THE FIRST LADY WHEN SHE VISITED 672 00:29:46,496 --> 00:29:50,901 RESEARCH TRIANGLE IN NORTH 673 00:29:50,901 --> 00:29:52,569 CAROLINA TO HELP DISSEMINATE THE 674 00:29:52,569 --> 00:29:54,437 EXECUTIVE ORDER JOINED BY THE 675 00:29:54,437 --> 00:29:57,574 GOVERNOR AND MAYOR OF DURHAM 676 00:29:57,574 --> 00:29:58,608 NORTH CAROLINA AS WELL 677 00:29:58,608 --> 00:30:00,844 INVESTIGATORS AND LEADERS IN 678 00:30:00,844 --> 00:30:02,345 INNOVATION IN THE PRIVATE 679 00:30:02,345 --> 00:30:02,579 SECTOR. 680 00:30:02,579 --> 00:30:04,514 HERE SHE SAID SO MANY OF US AND 681 00:30:04,514 --> 00:30:06,149 THE WOMEN IN OUR LIVES SUFFER 682 00:30:06,149 --> 00:30:08,618 FROM HEALTH CONDITIONS FOR WHICH 683 00:30:08,618 --> 00:30:09,886 WE SIMPLY DON'T HAVE THE ANSWERS 684 00:30:09,886 --> 00:30:11,121 OR SOLUTIONS. 685 00:30:11,121 --> 00:30:14,724 I WAS ALSO EXCITED TO BE JOINED 686 00:30:14,724 --> 00:30:18,194 BY DR. PERRY WHO SPOKE AT THE 687 00:30:18,194 --> 00:30:23,099 LAST YEAR'S SYMPOSIUM ON 688 00:30:23,099 --> 00:30:23,934 MENOPAUSE AND MID LIFE HEALTH 689 00:30:23,934 --> 00:30:25,902 AND IS A CHAIR AT THE UNIVERSITY 690 00:30:25,902 --> 00:30:36,413 OF NORTH CAROLINA CHAPEL HILL. 691 00:30:43,553 --> 00:30:45,288 AND IN ALIGNMENT WITH THE WHITE 692 00:30:45,288 --> 00:30:47,924 HOUSE INITIATIVE ON WOMEN'S 693 00:30:47,924 --> 00:30:51,194 HEALTH RESEARCH, NIH ISSUED A & 694 00:30:51,194 --> 00:30:52,028 ASSOCIATES SPECIAL INTEREST IN 695 00:30:52,028 --> 00:30:53,463 RECEIVING RESEARCH APPLICATIONS 696 00:30:53,463 --> 00:30:54,864 FOCUSSED ON DISEASE AND 697 00:30:54,864 --> 00:30:57,867 CONDITIONS THAT PREDOMINANTLY 698 00:30:57,867 --> 00:31:01,438 AFFECT WOMEN LIKE AUTO IMMUNE 699 00:31:01,438 --> 00:31:03,807 AND PRESENT AND PROGRESS 700 00:31:03,807 --> 00:31:04,741 DIFFERENT OR FEMALE SPECIFIC 701 00:31:04,741 --> 00:31:12,749 LIKE ENDOMETRIOSIS AND THIS IS 702 00:31:12,749 --> 00:31:13,416 SOMETHING VIRTUALLY EVERY CENTER 703 00:31:13,416 --> 00:31:14,751 HAS SIGNED ON TO AND MULTIPLE 704 00:31:14,751 --> 00:31:15,118 OFFICES. 705 00:31:15,118 --> 00:31:18,922 IT'S LINKED TO ALL THE NIH 706 00:31:18,922 --> 00:31:21,558 PARENT FUNDING OPPORTUNITIES. 707 00:31:21,558 --> 00:31:25,428 SO THIS ALLOWS BROAD MECHANISMS, 708 00:31:25,428 --> 00:31:27,764 MULTIPLE PATHWAYS FROM MULTIPLE 709 00:31:27,764 --> 00:31:29,099 TOPICS AND DISCIPLINES 710 00:31:29,099 --> 00:31:30,266 INVESTIGATORS IT APPLY FOR 711 00:31:30,266 --> 00:31:31,968 RESEARCH TO ADDRESS EVERY ASPECT 712 00:31:31,968 --> 00:31:32,669 OF WOMEN'S HEALTH ACROSS THE 713 00:31:32,669 --> 00:31:36,072 BOARD. 714 00:31:36,072 --> 00:31:39,909 FIRST RECEIVE DATE IS MAY 6 715 00:31:39,909 --> 00:31:41,811 AROUND THE CORNER. 716 00:31:41,811 --> 00:31:48,118 WE ALSOED -- ALSO CONTRIBUTED 717 00:31:48,118 --> 00:31:49,486 TO OTHER SECTORS IN THE POLICY 718 00:31:49,486 --> 00:31:49,853 SPACE. 719 00:31:49,853 --> 00:31:51,054 THERE'S A BLUEPRINT ESTABLISH 720 00:31:51,054 --> 00:31:52,422 TASK FORCE FROM THE WHITE HOUSE 721 00:31:52,422 --> 00:31:53,690 TO ADDRESS ONLINE HARASSMENT AND 722 00:31:53,690 --> 00:31:56,693 ABUSE. 723 00:31:56,693 --> 00:31:58,628 WE WERE PRIVILEGED TO 724 00:31:58,628 --> 00:32:00,964 PARTICIPATE AND MAKE REMARKS AT 725 00:32:00,964 --> 00:32:01,631 THE UNDERSTANDING AND ADDRESSING 726 00:32:01,631 --> 00:32:04,300 THE HEALTH IMPACTS OF ONLINE 727 00:32:04,300 --> 00:32:06,803 ABUSE AND HARASSMENT WORKSHOP. 728 00:32:06,803 --> 00:32:10,106 THE REASON WHY THIS IS SO 729 00:32:10,106 --> 00:32:12,108 IMPORTANT IS THAT FOUR IN 10 730 00:32:12,108 --> 00:32:13,209 ADULT AMERICANS EXPERIENCE 731 00:32:13,209 --> 00:32:15,211 ONLINE HARASSMENT AND IT'S A 732 00:32:15,211 --> 00:32:20,150 GROWING NUMBER. 733 00:32:20,150 --> 00:32:22,052 ONLINE HARASSMENT 734 00:32:22,052 --> 00:32:22,886 DISPROPORTIONATELY AFFECTED 735 00:32:22,886 --> 00:32:25,789 WOMEN AND GIRLS AND HALF OF 736 00:32:25,789 --> 00:32:30,694 GIRLS 15 TO 17 OVER HALF HAVE 737 00:32:30,694 --> 00:32:32,529 EXPERIENCED OVER ONE IN SIX 738 00:32:32,529 --> 00:32:34,964 CYBER BULLYING BEHAVIOR. 739 00:32:34,964 --> 00:32:37,367 IT'S ONE WAY DATA AND CAN INFORM 740 00:32:37,367 --> 00:32:38,401 POLICY AND HOW POLICY CAN MAKE 741 00:32:38,401 --> 00:32:39,502 AN IMPACT. 742 00:32:39,502 --> 00:32:41,371 THIS WAS WIDELY VIEWED AND 743 00:32:41,371 --> 00:32:43,673 PICKED UP BY THE MAINSTREAM 744 00:32:43,673 --> 00:32:44,374 MEDIA AS WELL. 745 00:32:44,374 --> 00:32:46,609 THIS IS ANOTHER MOMENT WHERE I 746 00:32:46,609 --> 00:32:49,446 GET TO THANK YOU AS ADVISORY 747 00:32:49,446 --> 00:32:50,080 COMMITTEE MEMBERS FOR SOME OF 748 00:32:50,080 --> 00:32:51,014 THE WORK YOU'VE DONE. 749 00:32:51,014 --> 00:32:53,483 THE REPORT OF THIS ADVISORY 750 00:32:53,483 --> 00:32:55,185 COMMITTEE OF RESEARCH ON WOMEN'S 751 00:32:55,185 --> 00:32:59,723 HEALTH AND THE NIH REPORT AND 752 00:32:59,723 --> 00:33:04,694 THE FY21-22 REPORT WAS RELEASED. 753 00:33:04,694 --> 00:33:06,129 THIS REPRESENTS SCIENTIFIC 754 00:33:06,129 --> 00:33:07,530 ADVANCEMENTS THE INSTITUTES AND 755 00:33:07,530 --> 00:33:08,565 CENTERS SUPPORTED. 756 00:33:08,565 --> 00:33:16,206 IT PROVIDE A SUMMARY OF RESEARCH 757 00:33:16,206 --> 00:33:18,041 AND TO OUR COMPLIANCE WITH 758 00:33:18,041 --> 00:33:18,608 POLICY. 759 00:33:18,608 --> 00:33:20,076 YOU'LL RECEIVE A FULL UPDATE 760 00:33:20,076 --> 00:33:23,947 FROM THE NIH INCLUSION POLICY 761 00:33:23,947 --> 00:33:27,550 AND DR. DAWN CORBETT WHO IS HERE 762 00:33:27,550 --> 00:33:29,652 AND PROVIDE DATA ON WORKFORCE 763 00:33:29,652 --> 00:33:31,454 DEMOGRAPHICS OF NIH SCIENTISTS 764 00:33:31,454 --> 00:33:34,390 AS WELL AS THE DEMOGRAPHICS OF 765 00:33:34,390 --> 00:33:35,391 NIH GRANTEES ARE INCLUDED IN THE 766 00:33:35,391 --> 00:33:36,159 REPORT. 767 00:33:36,159 --> 00:33:39,896 AND FOR THE FIRST TIME WE 768 00:33:39,896 --> 00:33:42,132 CREATED A SECTION CALLED 769 00:33:42,132 --> 00:33:43,500 CROSS-CUTTING INTEGRATIVE TOPICS 770 00:33:43,500 --> 00:33:44,200 IN RESEARCH. 771 00:33:44,200 --> 00:33:45,935 EVERY INSTITUTE AND CENTER AT 772 00:33:45,935 --> 00:33:46,536 NIH SUPPORTS WOMEN'S HEALTH 773 00:33:46,536 --> 00:33:51,040 RESEARCH ALIGNED WITH THEIR 774 00:33:51,040 --> 00:33:52,642 RESPECTIVE MISSION AREAS AND 775 00:33:52,642 --> 00:33:55,044 THERE'S TOPICS LIKE AUTO IMMUNE 776 00:33:55,044 --> 00:33:55,812 DISEASE AND SOCIAL DETERMINATES 777 00:33:55,812 --> 00:33:56,746 THAT OVERLAP. 778 00:33:56,746 --> 00:33:59,616 WE PULLED THE TOPICS AGING ON 779 00:33:59,616 --> 00:34:01,751 AUTO IMMUNE DISEASE AND MENTAL 780 00:34:01,751 --> 00:34:04,287 HEALTH AND MORBIDITY AND 781 00:34:04,287 --> 00:34:11,394 MORTALITY, SOCIAL DISTANCES AND 782 00:34:11,394 --> 00:34:15,865 WHERE IMPACT TO CONVEY IN AN 783 00:34:15,865 --> 00:34:16,499 INTERDISCIPLINARY CROSS-CUTTING 784 00:34:16,499 --> 00:34:21,171 WAY. 785 00:34:21,171 --> 00:34:23,273 I WANT TO THANK THE ADVISORY 786 00:34:23,273 --> 00:34:25,041 COMMITTEE MEMBERS FOR AMAZING 787 00:34:25,041 --> 00:34:26,743 WORK AND THIS IS YOUR REPORT YOU 788 00:34:26,743 --> 00:34:29,746 DO WITH US ON BEHALF OF NIH AND 789 00:34:29,746 --> 00:34:33,349 WE'RE GRATEFUL FOR YOUR EFFORTS 790 00:34:33,349 --> 00:34:35,885 AND TO THE INSTITUTES AND 791 00:34:35,885 --> 00:34:37,487 CENTERS AND OFFICES THAT ALL 792 00:34:37,487 --> 00:34:38,755 SUPPORT WOMEN'S HEALTH RESEARCH. 793 00:34:38,755 --> 00:34:41,558 IT'S FANTASTIC TO SEE THE 794 00:34:41,558 --> 00:34:43,893 SCIENTIFIC ADVANCE IN A SINGLE 795 00:34:43,893 --> 00:34:48,932 PLACE. 796 00:34:48,932 --> 00:34:50,934 THE INNOVATION EQUITY FORUM IS 797 00:34:50,934 --> 00:34:53,403 ANOTHER ACTIVITY I'D LIKE TO 798 00:34:53,403 --> 00:34:54,537 SHOUT OUT. 799 00:34:54,537 --> 00:34:59,342 MEMBERS FROM DIVERSE BACKGROUNDS 800 00:34:59,342 --> 00:35:03,913 AND THE AIM WAS TO FORM THIS 801 00:35:03,913 --> 00:35:05,782 BROAD MULTIDISCIPLINARY GROUP 802 00:35:05,782 --> 00:35:08,017 WITH EXPERTISE FROM DIFFERENT 803 00:35:08,017 --> 00:35:09,519 SECTORS BY DIVERSE PERSPECTIVES 804 00:35:09,519 --> 00:35:13,823 AND HAVE AN IMPACT BY HAVING AN 805 00:35:13,823 --> 00:35:15,225 INCLUSIVE, GLOBALLY FOCUSSED 806 00:35:15,225 --> 00:35:16,125 DELIVERY OF PRODUCTS I'LL SHOW 807 00:35:16,125 --> 00:35:17,760 IN THE NEXT SLAYED CALLED THE 808 00:35:17,760 --> 00:35:20,363 OPPORTUNITY MAP. 809 00:35:20,363 --> 00:35:22,065 NEXT SLIDE. 810 00:35:22,065 --> 00:35:24,467 THE FOCUS WAS TO ADDRESS ALL 811 00:35:24,467 --> 00:35:27,070 ORGAN SYSTEMS THAT AFFECT WOMEN 812 00:35:27,070 --> 00:35:28,638 HEAD TO TOE ACROSS THE LIFE 813 00:35:28,638 --> 00:35:29,606 COURSE INCLUDING UNDERSTANDING 814 00:35:29,606 --> 00:35:31,040 THE DISEASES AND CONDITIONS THAT 815 00:35:31,040 --> 00:35:35,612 OCCUR ONLY IN WOMEN ANDLY 816 00:35:35,612 --> 00:35:39,849 MOST -- AND MOSTLY IN WOMEN AND 817 00:35:39,849 --> 00:35:40,483 HAVE BROAD REPRESENTATION FROM 818 00:35:40,483 --> 00:35:43,887 13 SECTORS AND MULTIPLE GENDERS 819 00:35:43,887 --> 00:35:46,122 AND THE STRATEGY HERE IS THAT BY 820 00:35:46,122 --> 00:35:47,690 INVESTING IN UNMET NEEDS THE 821 00:35:47,690 --> 00:35:48,992 GOAL IS TO ACCELERATE INNOVATION 822 00:35:48,992 --> 00:35:51,261 FOR WOMEN'S HEALTH AND 823 00:35:51,261 --> 00:35:53,396 ULTIMATELY REDUCE MORBIDITY AND 824 00:35:53,396 --> 00:35:54,030 MORTALITY AND INCREASE THE WELL 825 00:35:54,030 --> 00:35:54,797 BEING OF WOMEN. 826 00:35:54,797 --> 00:36:00,270 I DO WANT TO ACKNOWLEDGE JAMIE 827 00:36:00,270 --> 00:36:04,941 WHITE, FORMER ORWH AND DR. MICA 828 00:36:04,941 --> 00:36:07,110 THE FORMER CHAIRS AND HERE'S CHA 829 00:36:07,110 --> 00:36:08,311 WHAT THEY DELIVERED. 830 00:36:08,311 --> 00:36:09,979 THEY DELIVERED AN OPPORTUNITY 831 00:36:09,979 --> 00:36:13,883 MAP LAYING OUT 50 EQUITABLE 832 00:36:13,883 --> 00:36:14,517 HIGH-RETURN OPPORTUNITIES TO 833 00:36:14,517 --> 00:36:17,787 ADDRESS GLOBAL INNOVATION FOR 834 00:36:17,787 --> 00:36:18,221 WOMEN'S HEALTH. 835 00:36:18,221 --> 00:36:20,156 THEY NEEDED TO ADDRESS NEW 836 00:36:20,156 --> 00:36:22,792 MARKETS AND OPPORTUNITIES, 837 00:36:22,792 --> 00:36:24,961 REDUCE MORBIDITY AND MORTALITY, 838 00:36:24,961 --> 00:36:27,830 IMPROVE SOCIETAL OUTCOMES, 839 00:36:27,830 --> 00:36:31,367 INCLUDE STRONGER ECONOMIES AND 840 00:36:31,367 --> 00:36:32,335 LEADERSHIP WITH WOMEN'S HEALTH 841 00:36:32,335 --> 00:36:36,873 AND WELL BEING AT THE CENTER. 842 00:36:36,873 --> 00:36:38,841 YOU CAN SEE HERE WE USE THE 843 00:36:38,841 --> 00:36:40,410 CRITERIA TO PRIORITIZE THE MANY 844 00:36:40,410 --> 00:36:44,447 NEEDS AROUND THE WORLD. 845 00:36:44,447 --> 00:36:47,550 THEY HAD TO HAVE POTENTIAL FOR 846 00:36:47,550 --> 00:36:51,220 IMPACT AND NEEDED TO BE READY TO 847 00:36:51,220 --> 00:36:53,856 MOVE FORWARD AND SUPPORT WOMEN 848 00:36:53,856 --> 00:36:55,658 AND WE CALL THEM THE PRIME 849 00:36:55,658 --> 00:36:55,925 CRITERIA. 850 00:36:55,925 --> 00:36:58,695 WE USE THE LENSES AN THESE ARE 851 00:36:58,695 --> 00:37:05,868 THE 10 SECTIONS OF THE REPORT TO 852 00:37:05,868 --> 00:37:07,070 ADVANCE OPPORTUNITIES FOR 853 00:37:07,070 --> 00:37:08,204 EQUITABLE INNOVATION. 854 00:37:08,204 --> 00:37:10,173 THERE'S ALSO CROSS-CUTTING 855 00:37:10,173 --> 00:37:12,175 TOPICS LISTED ON THE BOTTOM. 856 00:37:12,175 --> 00:37:15,111 I'LL HIGHLIGHT IN MY NEXT SLIDE 857 00:37:15,111 --> 00:37:16,245 A FEW OF THE OPPORTUNITIES IN 858 00:37:16,245 --> 00:37:18,715 THE RESEARCH DESIGN AND 859 00:37:18,715 --> 00:37:27,357 METHODOLOGY SPACE. 860 00:37:27,357 --> 00:37:29,225 I WAS TO ADVANCE SEX AND GENDER 861 00:37:29,225 --> 00:37:31,260 AND ANALYSIS IN ALL RESEARCH 862 00:37:31,260 --> 00:37:33,296 STAGES TO PROMOTE KNOWLEDGE AND 863 00:37:33,296 --> 00:37:34,897 RESOURCE SHARING IN THE 864 00:37:34,897 --> 00:37:35,932 PRECLINICAL AND CLINICAL 865 00:37:35,932 --> 00:37:37,400 RESEARCH LANDSCAPE, STRENGTHEN 866 00:37:37,400 --> 00:37:40,169 THE USE OF COMPUTATION AND BIO 867 00:37:40,169 --> 00:37:43,172 INFORMATICS AND DEEP LEARNING 868 00:37:43,172 --> 00:37:44,507 APPROACHES AND TO SUPPORT IN 869 00:37:44,507 --> 00:37:46,709 VITRO AND OTHER MODEL 870 00:37:46,709 --> 00:37:47,844 DEVELOPMENT LIKE ORGANS ON A 871 00:37:47,844 --> 00:37:55,618 CHIP AND OTHERS. 872 00:37:55,618 --> 00:38:02,525 HERE'S KEY INTERESTED PARTIES 873 00:38:02,525 --> 00:38:03,159 AND THIS MAPS THE FIRST STEP TO 874 00:38:03,159 --> 00:38:03,793 GATHER THE INDIVIDUAL AND SECTOR 875 00:38:03,793 --> 00:38:07,497 PARTNERS IN THE R&D ECO SYSTEM 876 00:38:07,497 --> 00:38:07,997 AND COALESCE AROUND THE 877 00:38:07,997 --> 00:38:11,000 POTENTIAL FOR IMPACTFUL 878 00:38:11,000 --> 00:38:11,634 INVESTMENTS THAT ARE IMPORTANT 879 00:38:11,634 --> 00:38:12,201 STEPS AND OPPORTUNITIES IT 880 00:38:12,201 --> 00:38:15,938 NEEDED TO IMPROVE WOMEN'S 881 00:38:15,938 --> 00:38:17,840 HEALTH. 882 00:38:17,840 --> 00:38:21,711 IN ADDITION WE HAVE A SIGNATURE 883 00:38:21,711 --> 00:38:22,378 PROGRAM IN PARTNERSHIP WITH THE 884 00:38:22,378 --> 00:38:24,847 OFFICE OF AIDS AND PUT OUT AN 885 00:38:24,847 --> 00:38:27,417 RFI LOOK FOR INPUT ON RESEARCH 886 00:38:27,417 --> 00:38:29,385 OPPORTUNITIES AND RECEIVED INPUT 887 00:38:29,385 --> 00:38:31,854 FROM A VARIETY OF INDIVIDUALS, 888 00:38:31,854 --> 00:38:33,189 REMIND RESPONDENTS FROM 889 00:38:33,189 --> 00:38:34,791 RESEARCH, COMMUNITY MEMBERS, 890 00:38:34,791 --> 00:38:36,926 PROVIDERS, INDIVIDUALS WITH HIV 891 00:38:36,926 --> 00:38:41,197 AND ORGANIZATIONS AND ADVOCACY 892 00:38:41,197 --> 00:38:41,831 GROUPS. 893 00:38:41,831 --> 00:38:43,299 THAT INFORMATION IS BEING 894 00:38:43,299 --> 00:38:47,870 COLLATED TO NUMBER OUR NEXT 895 00:38:47,870 --> 00:38:57,980 STEPS 896 00:39:25,174 --> 00:39:30,880 AND I HOSTED A NIH WOMEN'S 897 00:39:30,880 --> 00:39:33,249 WORKSHOP TO FOSTER 898 00:39:33,249 --> 00:39:36,352 INTERDISCIPLINARY, 899 00:39:36,352 --> 00:39:36,786 INTERSECTIONAL AND 900 00:39:36,786 --> 00:39:37,386 COMMUNITY-CENTERED KNOWLEDGE 901 00:39:37,386 --> 00:39:39,155 EXCHANGE ON TOPICS OF RELEVANCE 902 00:39:39,155 --> 00:39:40,790 TO HIV AND CISGENDER AND GENDER 903 00:39:40,790 --> 00:39:43,559 DIVERSE PEOPLE TO REVIEW THE 904 00:39:43,559 --> 00:39:45,294 STATE OF SCIENCE TO HIGHLIGHT 905 00:39:45,294 --> 00:39:47,897 MODIFIABLE FACTORS SO WE COULD 906 00:39:47,897 --> 00:39:49,432 LOOK AT PREVENTION AND 907 00:39:49,432 --> 00:39:50,700 DIAGNOSTIC TREATMENT AND CURE 908 00:39:50,700 --> 00:40:00,910 FOR ALL WITH HIV AND IDENTIFY 909 00:40:00,910 --> 00:40:01,444 OPPORTUNITIES TO ADVANCE 910 00:40:01,444 --> 00:40:01,711 RESEARCH. 911 00:40:01,711 --> 00:40:02,345 I'D LIKE TO GIVE AN UPDATE ON 912 00:40:02,345 --> 00:40:03,646 THE OFFICE OF AUTO IMMUNE 913 00:40:03,646 --> 00:40:06,115 DIVERSE RESEARCH IN FY23 WE 914 00:40:06,115 --> 00:40:07,917 FUNDED 41 APPLICATIONS FROM 12 915 00:40:07,917 --> 00:40:09,919 INSTITUTE, CENTER OR OFFICES AND 916 00:40:09,919 --> 00:40:10,753 BROKEN DOWN AS LISTED HERE. 917 00:40:10,753 --> 00:40:13,489 I WANT TO HIGHLIGHT A 918 00:40:13,489 --> 00:40:15,057 PUBLIC-PRIVATE PARTNERSHIP 919 00:40:15,057 --> 00:40:19,896 ACCELERATING MEDICINE'S 920 00:40:19,896 --> 00:40:22,565 PARTNERSHIP ON AUTO IMMUNE OR 921 00:40:22,565 --> 00:40:22,798 AMP AIM. 922 00:40:22,798 --> 00:40:23,900 WE HAVE TWO SCIENTIFIC AWARDS 923 00:40:23,900 --> 00:40:26,502 THERE AS WELL. 924 00:40:26,502 --> 00:40:33,009 WE ALSO SUPPORTED 10 INTRAMURAL 925 00:40:33,009 --> 00:40:33,643 RESEARCH PROGRAMS AND TRAINEES 926 00:40:33,643 --> 00:40:43,953 AND I'LL HIGHLIGHT 927 00:40:53,663 --> 00:40:56,732 AS WELL AS BE AN UPDATE ON MAY 928 00:40:56,732 --> 00:41:01,037 AND ANALYZING AN UPDATE ON AUTO 929 00:41:01,037 --> 00:41:03,906 IMMUNE DISEASE AND PUBLISHED AN 930 00:41:03,906 --> 00:41:05,541 INTRODUCTION TO THE OFFICE OF 931 00:41:05,541 --> 00:41:06,776 AUTO IMMUNE DISEASE RESEARCH 932 00:41:06,776 --> 00:41:07,410 HIGHLIGHTING OUR FIRST YEAR OF 933 00:41:07,410 --> 00:41:07,910 FUNDING. 934 00:41:07,910 --> 00:41:13,783 I WANT TO ACKNOWLEDGE THE OADR 935 00:41:13,783 --> 00:41:15,785 CORE THAT STOOD UP OADR IN THE 936 00:41:15,785 --> 00:41:22,592 FIRST YEAR AS WE CAME INTO 937 00:41:22,592 --> 00:41:24,594 HIRING THANK YOU TO THE MEMBERS 938 00:41:24,594 --> 00:41:26,028 WHO TOOK UP THE MANTLE AND 939 00:41:26,028 --> 00:41:28,731 STEPPED UP IN A VERY BIG WAY IN 940 00:41:28,731 --> 00:41:31,000 ADDITION TO THEIR USUAL DUTIES. 941 00:41:31,000 --> 00:41:33,769 I APPRECIATE ALL YOUR EFFORTS. 942 00:41:33,769 --> 00:41:35,104 IT'S VERY EXCITING TO HAVE 943 00:41:35,104 --> 00:41:37,640 DR. CRISWELL HERE TO SHARE WITH 944 00:41:37,640 --> 00:41:46,682 YOU THIS PARTNERSHIP WITH NAIMS 945 00:41:46,682 --> 00:41:55,291 ANNOUNCING THE AWARDEES AND 946 00:41:55,291 --> 00:41:57,893 THESE ARE PLANNING GRANTS DESIGN 947 00:41:57,893 --> 00:42:00,396 TO CREATE COLLABORATIONS AN 948 00:42:00,396 --> 00:42:01,731 RESEARCH FRAME WORKS TO NFL THE 949 00:42:01,731 --> 00:42:03,266 NETWORK WHICH WILL BE A NATIONAL 950 00:42:03,266 --> 00:42:05,401 RESEARCH COLLABORATIVE APPROACH 951 00:42:05,401 --> 00:42:06,736 THE NATIONAL INSTITUTE OF 952 00:42:06,736 --> 00:42:07,803 ENVIRONMENTAL HEALTH SCIENCES IS 953 00:42:07,803 --> 00:42:09,238 PLAYING A LEADERSHIP ROLE IN. 954 00:42:09,238 --> 00:42:11,907 THE GOAL IS TO DEVELOP A 955 00:42:11,907 --> 00:42:13,109 SYSTEMS-LEVEL APPROACH TO 956 00:42:13,109 --> 00:42:15,978 UNDERSTANDING MECHANISMS RELATED 957 00:42:15,978 --> 00:42:17,546 TO HOW EXPOSURES IN THE 958 00:42:17,546 --> 00:42:19,749 ENVIRONMENT PERTURB CELLULAR 959 00:42:19,749 --> 00:42:22,018 ORGAN AND TISSUE FUNCTION ACROSS 960 00:42:22,018 --> 00:42:24,887 MULTIPLE AUTO IMMUNE DISEASES 961 00:42:24,887 --> 00:42:25,488 AND I'M EXCITED TO SHARE THIS 962 00:42:25,488 --> 00:42:26,289 INFORMATION WITH YOU AND LOOK 963 00:42:26,289 --> 00:42:26,956 FORWARD TO HEARING FROM THEM IN 964 00:42:26,956 --> 00:42:30,293 THE FUTURE. 965 00:42:30,293 --> 00:42:33,863 AUTO IMMUNE DISEASES AND BASIC 966 00:42:33,863 --> 00:42:34,597 SCIENCE AND UNDERSTANDING HAS 967 00:42:34,597 --> 00:42:36,966 BEEN IN THE NEWS WITH NIH FUNDED 968 00:42:36,966 --> 00:42:42,138 RESEARCH BEING HIGHLIGHTED IN 969 00:42:42,138 --> 00:42:47,910 CELL RECENTLY AND POPULAR MEDIA 970 00:42:47,910 --> 00:42:48,611 AS WELL. 971 00:42:48,611 --> 00:42:51,881 IT OCCURS XIST CAN BIND WITH 972 00:42:51,881 --> 00:42:55,518 PROTEINS AND ONLY HAPPENS IN 973 00:42:55,518 --> 00:42:58,454 FEMALES AND YOU CAN SEE IT 974 00:42:58,454 --> 00:42:59,889 DELINEATED HERE. 975 00:42:59,889 --> 00:43:03,893 THIS IS AUTO ANTIGENIC IN ITSELF 976 00:43:03,893 --> 00:43:05,161 AND PURPORTED TO PLAY A ROLE IN 977 00:43:05,161 --> 00:43:06,529 WHY FEMALES HAVE MORE AUTO 978 00:43:06,529 --> 00:43:07,396 IMMUNE DISEASE. 979 00:43:07,396 --> 00:43:11,200 THIS WAS A REAL CLUE THAT NIH 980 00:43:11,200 --> 00:43:15,638 BASIC SCIENCE HELPED UNCOVER 981 00:43:15,638 --> 00:43:16,272 RELATED TO AUTO IMMUNE DISEASE 982 00:43:16,272 --> 00:43:21,143 AND SEX DIFFERENCES. 983 00:43:21,143 --> 00:43:21,777 AS I MENTIONED, DR. BERTAGNOLLI 984 00:43:21,777 --> 00:43:22,411 FEATURED AUTO IMMUNE DISEASES IN 985 00:43:22,411 --> 00:43:23,813 ONE OF HER BLOGS AND TALKED 986 00:43:23,813 --> 00:43:25,681 ABOUT THE BASIC SCIENCE AND HOW 987 00:43:25,681 --> 00:43:26,916 WE NEED TO MAKE SURE THOSE 988 00:43:26,916 --> 00:43:29,251 INVESTMENTS IN BASIC SCIENCE TO 989 00:43:29,251 --> 00:43:39,395 HELP US 990 00:44:29,945 --> 00:44:31,180 -- FOR SUPPORTING CAREGIVERS 991 00:44:31,180 --> 00:44:33,149 WORKING IN SCIENCE, ENGINEERING 992 00:44:33,149 --> 00:44:36,719 AND MEDICINE WILL BE RELEASED. 993 00:44:36,719 --> 00:44:37,853 ORWH HAS BEEN PLEASED TO SUPPORT 994 00:44:37,853 --> 00:44:38,287 BOTH EFFORT. 995 00:44:38,287 --> 00:44:43,459 IN ADDITION, WE HAVE ALSO 996 00:44:43,459 --> 00:44:45,161 SUPPORTED RESEARCH ON ADDRESSING 997 00:44:45,161 --> 00:44:46,862 SEXUAL HARASSMENT. 998 00:44:46,862 --> 00:44:48,531 SEVERAL YEARS AGO THE THEN NIH 999 00:44:48,531 --> 00:44:51,233 DIRECTOR DR. FRANCIS COLLINS 1000 00:44:51,233 --> 00:44:52,301 CREATED AN ADVISORY COMMITTEE TO 1001 00:44:52,301 --> 00:44:54,637 THE WORKING GROUP ON ENDING 1002 00:44:54,637 --> 00:44:55,905 SEXUAL HARASSMENT. 1003 00:44:55,905 --> 00:44:57,106 I WAS PRIVILEGED TO BE ON THAT 1004 00:44:57,106 --> 00:44:58,040 WORKING GROUP. 1005 00:44:58,040 --> 00:44:59,775 FOLLOWING THAT GROUP, NIGMS HAD 1006 00:44:59,775 --> 00:45:03,813 A FUNDING OPPORTUNITY ON 1007 00:45:03,813 --> 00:45:04,313 INTERVENTIONS INCLUDING 1008 00:45:04,313 --> 00:45:05,781 POTENTIAL STRATEGIES RELATED TO 1009 00:45:05,781 --> 00:45:16,258 SEXUAL HARASSMENT AND ORWH 1010 00:45:18,093 --> 00:45:18,594 HELPED FUND A GRANT ONGOING. 1011 00:45:18,594 --> 00:45:19,228 HERE'S ONE OF THE PUBLICATIONS 1012 00:45:19,228 --> 00:45:19,862 FROM ONE OF THOSE GRANTS AND WE 1013 00:45:19,862 --> 00:45:21,330 LOOK FORWARD TO FUTURE 1014 00:45:21,330 --> 00:45:21,764 PUBLICATIONS. 1015 00:45:21,764 --> 00:45:24,533 THE NATIONAL ACADEMIES HAS AN 1016 00:45:24,533 --> 00:45:26,769 ACTION COLLABORATIVE WITH 1017 00:45:26,769 --> 00:45:27,269 MULTIPLE ORGANIZATIONS 1018 00:45:27,269 --> 00:45:34,009 COALESCING AROUND THE NEED TO 1019 00:45:34,009 --> 00:45:34,610 PREVENT SEXUAL HARASSMENT AND 1020 00:45:34,610 --> 00:45:35,177 OUR ASSOCIATE DIRECTOR OF 1021 00:45:35,177 --> 00:45:37,112 CAREERS HERE IN THE AUDIENCE 1022 00:45:37,112 --> 00:45:38,881 PARTICIPATED ON AN ACTION 1023 00:45:38,881 --> 00:45:41,016 COLLABORATIVE ON TRANSFORMING 1024 00:45:41,016 --> 00:45:42,418 TRAJECTORIES FOR WOMEN OF COLOR 1025 00:45:42,418 --> 00:45:42,985 IN TECH. 1026 00:45:42,985 --> 00:45:44,854 THIS IS LOOKING MORE TOWARDS THE 1027 00:45:44,854 --> 00:45:47,923 TARGETED COLLECTIVE ACTION 1028 00:45:47,923 --> 00:45:51,260 GUIDED BY AN INTERSECTIONAL 1029 00:45:51,260 --> 00:45:52,161 APPROACH AND THERE'S A LARGE 1030 00:45:52,161 --> 00:45:53,696 NUMBER OF ACTIVITIES. 1031 00:45:53,696 --> 00:45:55,898 FURTHER LATER THIS WEEK, THE 1032 00:45:55,898 --> 00:45:57,933 COMMITTEE ON THE ADVANCEMENT 1033 00:45:57,933 --> 00:46:01,804 OF -- ASSESSMENT OF NIH WOMEN'S 1034 00:46:01,804 --> 00:46:03,939 HEALTH ONGOING IS HAVING A 1035 00:46:03,939 --> 00:46:06,475 PUBLIC MEETING SOLICITING INPUT 1036 00:46:06,475 --> 00:46:09,311 AND DR. TARA SCHWETZ WILL BE 1037 00:46:09,311 --> 00:46:10,145 PRESENTING THERE THURSDAY. 1038 00:46:10,145 --> 00:46:12,715 LASTLY, AT THE END OF APRIL, A 1039 00:46:12,715 --> 00:46:13,382 WORKSHOP WILL BE HELD WITH 1040 00:46:13,382 --> 00:46:16,285 NATIONAL INSTITUTE OF MENTAL 1041 00:46:16,285 --> 00:46:17,953 HEALTH INVOLVEMENT ON ESSENTIAL 1042 00:46:17,953 --> 00:46:22,791 HEALTH CARE SERVICES RELATED TO 1043 00:46:22,791 --> 00:46:24,326 ANXIETY AND MOOD DISORDERS IN 1044 00:46:24,326 --> 00:46:26,228 WOMEN. 1045 00:46:26,228 --> 00:46:26,695 A LOT OF ACTION THERE. 1046 00:46:26,695 --> 00:46:27,897 YOU'VE HEARD HERE ABOUT THE 1047 00:46:27,897 --> 00:46:29,632 PATHWAYS TO PREVENTION PROGRAM 1048 00:46:29,632 --> 00:46:30,833 IN THE PAST AND I'M EXCITED TO 1049 00:46:30,833 --> 00:46:32,635 SHARE WITH YOU THAT IN ADDITION 1050 00:46:32,635 --> 00:46:36,038 TO THE INDEPENDENT PANEL REPORT, 1051 00:46:36,038 --> 00:46:39,208 THE INDEPENDENT PANEL SUMMARY, 1052 00:46:39,208 --> 00:46:49,552 AND SYSTEMATIC EVIDENCE REVIEW 1053 00:46:49,552 --> 00:46:50,185 AND MAP ON SOCIAL AND STRUCTURAL 1054 00:46:50,185 --> 00:46:50,719 DETERMINATES FOR MATERNAL 1055 00:46:50,719 --> 00:46:51,320 MORBIDITY, AND MORTALITY THE 1056 00:46:51,320 --> 00:46:51,921 FEDERAL PARTNERS REPORT WAS 1057 00:46:51,921 --> 00:46:52,354 RECENTLY ADDRESSED. 1058 00:46:52,354 --> 00:46:52,922 ALL THESE DELIVERABLES ARE 1059 00:46:52,922 --> 00:46:53,556 AVAILABLE ON THE OFFICE OF 1060 00:46:53,556 --> 00:46:54,189 DISEASE PREVENTION WEBSITE FOR 1061 00:46:54,189 --> 00:46:55,891 THE PATHWAYS TO PREVENTION 1062 00:46:55,891 --> 00:46:59,395 PROGRAM. 1063 00:46:59,395 --> 00:47:01,664 SO WE ARE SEEING IN THOSE 1064 00:47:01,664 --> 00:47:03,399 DELIVERABLES A CALL FOR A 1065 00:47:03,399 --> 00:47:08,404 MATERNAL HEALTH MOONSHOT TO 1066 00:47:08,404 --> 00:47:09,038 ADDRESS MATERNAL MORBIDITY AND 1067 00:47:09,038 --> 00:47:09,672 MORTALITY IN THIS COUNTRY IN 1068 00:47:09,672 --> 00:47:12,274 WAYS THAT WILL MOVE THE NEEDLE 1069 00:47:12,274 --> 00:47:16,245 AND REDUCE MATERNAL MORTALITY. 1070 00:47:16,245 --> 00:47:18,681 EXCITING NEWS OF THE OFFICE OF 1071 00:47:18,681 --> 00:47:23,586 DISEASE PREVENTION. 1072 00:47:23,586 --> 00:47:24,153 ON A PATHWAYS TO PREVENTION 1073 00:47:24,153 --> 00:47:24,753 WORKSHOP ON THE MANAGEMENT OF 1074 00:47:24,753 --> 00:47:25,187 MENOPAUSE SYMPTOMS. 1075 00:47:25,187 --> 00:47:28,190 AS WE KNOW MENOPAUSE IS A NORMAL 1076 00:47:28,190 --> 00:47:29,091 PHASE OF LIFE BUT THE EXPERIENCE 1077 00:47:29,091 --> 00:47:30,259 CAN BE DIFFERENT FOR EVERYONE 1078 00:47:30,259 --> 00:47:35,931 AND CAN AFFECT QUALITY OF LIFE 1079 00:47:35,931 --> 00:47:37,600 AND THE DYNAMIC TRANSITION 1080 00:47:37,600 --> 00:47:39,902 SOMETHING WE NEED TO UNDERSTAND 1081 00:47:39,902 --> 00:47:41,637 BETTER IN SIGNALLING THE RISK 1082 00:47:41,637 --> 00:47:43,339 FOR CHRONIC DISEASE AND FOR 1083 00:47:43,339 --> 00:47:45,441 OTHER REASONS BUT MENOPAUSE WAS 1084 00:47:45,441 --> 00:47:47,710 SELECTED AS THE NEXT PATHWAYS TO 1085 00:47:47,710 --> 00:47:50,179 PROGRAMS AND THIS IS AN 1086 00:47:50,179 --> 00:47:51,714 IMPORTANT NEXT STEP IN 1087 00:47:51,714 --> 00:47:52,948 IDENTIFYING GAPS IN MENOPAUSE 1088 00:47:52,948 --> 00:47:53,282 RESEARCH. 1089 00:47:53,282 --> 00:47:56,151 WE'RE EXCITED TO BE PARTNERING 1090 00:47:56,151 --> 00:47:57,553 WITH MULTIPLE INSTITUTES AND 1091 00:47:57,553 --> 00:47:58,854 CENTERS ON THE EFFORT AND LOOK 1092 00:47:58,854 --> 00:48:01,657 FORWARD TO THAT WORKSHOP. 1093 00:48:01,657 --> 00:48:07,896 YOU MAY RECALL LAST YEAR THE 1094 00:48:07,896 --> 00:48:10,099 VIVIAN SYMPOSIUM LOOKED AT THIS 1095 00:48:10,099 --> 00:48:11,066 AND THE LEAD WAS ASSOCIATE 1096 00:48:11,066 --> 00:48:13,936 DIRECTOR FOR CLINICAL WRRCH. 1097 00:48:13,936 --> 00:48:17,740 AND TODAY YOU'LL HAVE A SPECIAL 1098 00:48:17,740 --> 00:48:24,413 PANEL CHAIRED BY DR. DUDA AND 1099 00:48:24,413 --> 00:48:26,015 HEAR FROM OTHERS ON THIS 1100 00:48:26,015 --> 00:48:26,582 IMPORTANT TOPIC. 1101 00:48:26,582 --> 00:48:29,785 CAN'T WAIT TO HEAR FROM THEM AND 1102 00:48:29,785 --> 00:48:31,420 DURING NATIONAL WOMEN'S HEALTH 1103 00:48:31,420 --> 00:48:34,957 WEEK WE'LL BE HOSTING OUR FIRST 1104 00:48:34,957 --> 00:48:40,763 EVER HHS ROUNDTABLE AN FUTURE 1105 00:48:40,763 --> 00:48:43,899 GOALS OF OPTIMIZING HEALTH IN 1106 00:48:43,899 --> 00:48:46,468 WOMEN AND THE CENTERS ON SEX 1107 00:48:46,468 --> 00:48:48,704 DIFFERENCES REPRESENTS NIH'S 1108 00:48:48,704 --> 00:48:50,906 ONLY CENTER LEVEL SEX 1109 00:48:50,906 --> 00:48:53,108 DIFFERENCES DISEASE AGNOSTIC 1110 00:48:53,108 --> 00:48:53,575 FUNDING OPPORTUNITY. 1111 00:48:53,575 --> 00:48:56,278 WE PARTNER WITH MULTIPLE 1112 00:48:56,278 --> 00:49:01,483 INSTITUTES AND CENTERS AS LETS 1113 00:49:01,784 --> 00:49:03,252 -- LISTED HERE ADDRESSING VERY 1114 00:49:03,252 --> 00:49:03,852 IMPORTANT TOPICS IN SPECIFIC 1115 00:49:03,852 --> 00:49:08,357 WAYS. 1116 00:49:08,357 --> 00:49:10,325 I WANT TO HIGHLIGHT OUR MOST 1117 00:49:10,325 --> 00:49:13,762 RECENTLY ADDED SCORE WHICH IS AT 1118 00:49:13,762 --> 00:49:14,463 AUGUSTA UNIVERSITY. 1119 00:49:14,463 --> 00:49:18,133 RURAL OBESE AND AT RISK IS THE 1120 00:49:18,133 --> 00:49:19,735 NAME OF THE PROGRAM AND HAS 1121 00:49:19,735 --> 00:49:20,602 MULTIPLE COMPONENTS SPANNING 1122 00:49:20,602 --> 00:49:23,706 THREE UNIVERSITIES, FOUR AUGUSTA 1123 00:49:23,706 --> 00:49:25,974 UNIVERSITY COLLEGES AND 10 1124 00:49:25,974 --> 00:49:26,275 DEPARTMENTS. 1125 00:49:26,275 --> 00:49:27,676 THE TOPICS THEY'RE ADDRESSING 1126 00:49:27,676 --> 00:49:37,886 ARE TIMELY. 1127 00:49:43,425 --> 00:49:43,959 THEY'RE ADDRESSING WOMEN WITH 1128 00:49:43,959 --> 00:49:44,626 AUTO IMMUNE DISEASE AND LOOKING 1129 00:49:44,626 --> 00:49:45,761 AT MECHANISMS THAT DRIVE 1130 00:49:45,761 --> 00:49:50,866 SUSCEPTIBILITY IN FEMALES VERSUS 1131 00:49:50,866 --> 00:49:54,036 MALES AND LOOKING AT HIGH BLOOD 1132 00:49:54,036 --> 00:49:58,841 PRESSURE AND THE AFFECT OF 1133 00:49:58,841 --> 00:50:02,111 LECTIN AN FEMALES WITH LUPUS AND 1134 00:50:02,111 --> 00:50:07,716 LOOKING AT INNATE CHANGES IN 1135 00:50:07,716 --> 00:50:09,384 RENAL FUNCTION IN WOMEN WITH 1136 00:50:09,384 --> 00:50:10,352 AUTO IMMUNE DISEASE. 1137 00:50:10,352 --> 00:50:12,254 THIS REPRESENTS THE STRATEGIES 1138 00:50:12,254 --> 00:50:14,490 OF THE SPECIALIZED CENTERS OF 1139 00:50:14,490 --> 00:50:15,390 EXCELLENCE ON SEX DIFFERENCES 1140 00:50:15,390 --> 00:50:18,160 WITH A REAL POWER TO ADDRESS THE 1141 00:50:18,160 --> 00:50:19,762 HEALTH OF WOMEN IN DEFINITIVE 1142 00:50:19,762 --> 00:50:22,564 WAYS THAT INCORPORATE SEX 1143 00:50:22,564 --> 00:50:23,198 DIFFERENCES AS WELL AS A FOCUS 1144 00:50:23,198 --> 00:50:24,700 ON THE HEALTH OF WOMEN. 1145 00:50:24,700 --> 00:50:26,568 IN TERM OF SEX AND GENDER 1146 00:50:26,568 --> 00:50:30,038 UPYOU'RE AWARE OF THE SEX AND 1147 00:50:30,038 --> 00:50:30,806 GENDER EQUITY AND RESEARCH 1148 00:50:30,806 --> 00:50:33,475 GUIDELINES AND WE HOSTED THE NIH 1149 00:50:33,475 --> 00:50:36,111 SEX AND GENDER DISEASE INTEREST 1150 00:50:36,111 --> 00:50:37,846 GROUP SEVERAL MONTHS AGO. 1151 00:50:37,846 --> 00:50:39,848 THAT EFFORT IS LED BY DR. HUNTER 1152 00:50:39,848 --> 00:50:42,951 OUR ASSOCIATE DIRECTOR FOR BASIC 1153 00:50:42,951 --> 00:50:43,952 AND TRANSLATIONAL RESEARCH AND 1154 00:50:43,952 --> 00:50:46,321 WE HAVE MULTIPLE SPEAKERS TALK 1155 00:50:46,321 --> 00:50:48,524 ON SEX AS A BIOLOGICAL VARIABLE 1156 00:50:48,524 --> 00:50:53,028 AND SEX-INCLUSIVE APPROACHES AND 1157 00:50:53,028 --> 00:50:54,229 JOINED BY A FORMER ADVISORY 1158 00:50:54,229 --> 00:50:55,898 COMMITTEE MEMBER AND HONORED BY 1159 00:50:55,898 --> 00:50:58,333 THE PRECISION MEDICINE WORLD 1160 00:50:58,333 --> 00:50:59,334 CONFERENCE EARLIER THIS YEAR 1161 00:50:59,334 --> 00:51:00,068 WITH AN INFECTION ON SEX AND 1162 00:51:00,068 --> 00:51:05,140 GENDER. 1163 00:51:05,140 --> 00:51:06,675 THE WORLD HEALTH ORGANIZATION 1164 00:51:06,675 --> 00:51:08,277 HAS ANNOUNCED ADOPTION OF THE 1165 00:51:08,277 --> 00:51:10,879 SEX AND GENDER EQUITY IN 1166 00:51:10,879 --> 00:51:11,914 RESEARCH GUIDELINES. 1167 00:51:11,914 --> 00:51:14,850 THEY ARE NOW PUTTING FORWARD 1168 00:51:14,850 --> 00:51:16,051 REPORTS THAT ARE DISAGGREGATED 1169 00:51:16,051 --> 00:51:18,187 BY SEX AND/OR GENDER AS 1170 00:51:18,187 --> 00:51:23,759 APPROPRIATE AND ON THIS WEBINAR 1171 00:51:23,759 --> 00:51:26,962 I WAS JOINED BY DR. CHEN FROM 1172 00:51:26,962 --> 00:51:28,997 THE GATES FOUNDATION AND OTHERS 1173 00:51:28,997 --> 00:51:30,599 AND THIS WAS HOSTED BY 1174 00:51:30,599 --> 00:51:33,402 DR. RICHARD HORTON OF THE LANCET 1175 00:51:33,402 --> 00:51:34,536 WHERE WE TALKED ABOUT HOW 1176 00:51:34,536 --> 00:51:38,574 IMPORTANT IT IS TO HAVE AN 1177 00:51:38,574 --> 00:51:39,107 ORGANIZATION LIKE W.H.O. 1178 00:51:39,107 --> 00:51:45,781 ADOPTING THE GUIDELINES TO 1179 00:51:45,781 --> 00:51:47,316 SUPPORT DISIMMIGRATION OF DATA 1180 00:51:47,316 --> 00:51:47,783 BY SEX AND GENDER AND 1181 00:51:47,783 --> 00:51:48,317 INCORPORATING INTO THEIR 1182 00:51:48,317 --> 00:51:48,784 OPERATING PRINCIPLES. 1183 00:51:48,784 --> 00:51:50,419 IN COLLABORATION WITH THE 1184 00:51:50,419 --> 00:51:51,453 NATIONAL CANCER INSTITUTE, THERE 1185 00:51:51,453 --> 00:51:54,189 ARE AN NIH SEX AND GENDER 1186 00:51:54,189 --> 00:51:54,857 DIFFERENCES CANCER WORK CHOMPS 1187 00:51:54,857 --> 00:51:56,592 NOW ORGANIZED. 1188 00:51:56,592 --> 00:51:57,526 THE NEXT IS ON CLINICAL SCIENCES 1189 00:51:57,526 --> 00:52:00,429 YOU CAN SEE HERE THEY INCLUDE A 1190 00:52:00,429 --> 00:52:02,197 KEY NOTE AS WELL AS RESEARCH 1191 00:52:02,197 --> 00:52:03,899 TALKS AND PANEL DISCUSSIONS. 1192 00:52:03,899 --> 00:52:04,766 DO JOIN US FOR THAT. 1193 00:52:04,766 --> 00:52:08,003 AND AS I MOVE INTO THE LAST 1194 00:52:08,003 --> 00:52:08,637 SECTION, OF THE PRESENTATION I 1195 00:52:08,637 --> 00:52:13,742 WANT TO HIGHLIGHT THE ORWH 1196 00:52:13,742 --> 00:52:14,109 BUDGET HISTORY. 1197 00:52:14,109 --> 00:52:15,644 I PROVIDE THIS FOR YOU EACH YEAR 1198 00:52:15,644 --> 00:52:17,279 AND DO SEE GOOD NEWS HERE. 1199 00:52:17,279 --> 00:52:18,947 IT'S BEEN A LITTLE FLAT FOR SOME 1200 00:52:18,947 --> 00:52:21,316 TIME THERE WITH NO CHANGE IN OUR 1201 00:52:21,316 --> 00:52:22,784 OVER ALL FUNDING AND IN FACT 1202 00:52:22,784 --> 00:52:24,019 THAT WOULD REPRESENT A DECREASE 1203 00:52:24,019 --> 00:52:26,188 IN OUR FUNDING BECAUSE OF 1204 00:52:26,188 --> 00:52:29,591 DECREASED BUYING POWER DUE TO 1205 00:52:29,591 --> 00:52:33,629 INFLATION HOWEVER, IN FY23 THE 1206 00:52:33,629 --> 00:52:35,731 CONSOLIDATIONS APPROPRIATIONS 1207 00:52:35,731 --> 00:52:37,933 ACT PROVIDED AN ADDITIONAL $10 1208 00:52:37,933 --> 00:52:39,801 MILLION TO CREATE THE OFFICE OF 1209 00:52:39,801 --> 00:52:41,036 AUTO IMMUNE DISEASE RESEARCH. 1210 00:52:41,036 --> 00:52:42,738 SO WE ARE EXCITED ABOUT THAT AND 1211 00:52:42,738 --> 00:52:44,806 YOU CAN SEE ON THE RIGHT ON THE 1212 00:52:44,806 --> 00:52:47,643 PIE CHART THE BREAKDOWN OF OUR 1213 00:52:47,643 --> 00:52:50,245 EXTRAMURAL RESEARCH FUNDING IN 1214 00:52:50,245 --> 00:52:50,646 TERMS OF PROGRAMS. 1215 00:52:50,646 --> 00:52:52,614 THIS SLIDE HIGHLIGHTS JUST THE 1216 00:52:52,614 --> 00:52:54,750 CAREER PROGRAMS. 1217 00:52:54,750 --> 00:52:56,251 WE DO LEAD A VARIETY OF THEM AND 1218 00:52:56,251 --> 00:52:57,920 I'LL TALK ABOUT THEM IN A 1219 00:52:57,920 --> 00:52:58,253 MOMENT. 1220 00:52:58,253 --> 00:53:01,490 THESE ARE THE -- THIS IS THE 1221 00:53:01,490 --> 00:53:07,896 BREAKDOWN OF ORWH FUNDING GOING 1222 00:53:07,896 --> 00:53:11,166 TO CO-FUNDING AND SEE THE BIRCWH 1223 00:53:11,166 --> 00:53:12,968 PROGRAM AND THE TOP INSTITUTES 1224 00:53:12,968 --> 00:53:19,007 IN TERMS OF GETTING GREATER 1225 00:53:19,007 --> 00:53:19,675 AMOUNTS OF ORWH FUNDING ALIGNED 1226 00:53:19,675 --> 00:53:22,244 WITH MISSIONARIES AND THE AGING 1227 00:53:22,244 --> 00:53:26,048 INSTITUTE AND NHLBI AND IF YOU 1228 00:53:26,048 --> 00:53:31,486 REMOVE THE BIRCWH PROGRAM YOU 1229 00:53:31,486 --> 00:53:32,120 SEE OTHERS AND THE GROUP IN THE 1230 00:53:32,120 --> 00:53:32,754 MIDDLE AND THEN THIS GROUP HERE 1231 00:53:32,754 --> 00:53:39,561 LOWER. 1232 00:53:39,561 --> 00:53:42,965 HERE'S THE SIGNATURE PROGRAMS 1233 00:53:42,965 --> 00:53:43,598 AND EXTRAMURAL INVESTMENTS WITH 1234 00:53:43,598 --> 00:53:43,932 OUR PARTNERS. 1235 00:53:43,932 --> 00:53:44,967 ON THE RIGHT, OUR INVESTMENTS 1236 00:53:44,967 --> 00:53:47,502 HERE AND THE NUMBER OF 1237 00:53:47,502 --> 00:53:49,938 CO-FUNDING I.C.s AND NUMBER OF 1238 00:53:49,938 --> 00:53:50,205 PARTNERS. 1239 00:53:50,205 --> 00:53:52,507 I'M NOT GOING TO LIST THEM BUT 1240 00:53:52,507 --> 00:53:53,809 YOU SEE A WIDE VARIETY OF 1241 00:53:53,809 --> 00:53:55,944 INSTITUTES AND CENTERS 1242 00:53:55,944 --> 00:53:59,881 SUPPORTING ORWH SIGNATURE 1243 00:53:59,881 --> 00:54:03,452 PROGRAMS THAT REPRESENT 1244 00:54:03,452 --> 00:54:04,086 COMPLEMENTARY PROGRAMS LEADING 1245 00:54:04,086 --> 00:54:06,021 TO THEIR EFFORTS AND WE CAN TALK 1246 00:54:06,021 --> 00:54:07,789 ABOUT THOSE IN MORE DETAIL 1247 00:54:07,789 --> 00:54:08,323 DURING THE DISCUSSION. 1248 00:54:08,323 --> 00:54:10,826 IN TERMS OF CAREER ADVANCEMENTS, 1249 00:54:10,826 --> 00:54:12,828 WE CREATED A TEAM-SCIENCE 1250 00:54:12,828 --> 00:54:15,731 LEADERSHIP SCHOLAR PROGRAM IN 1251 00:54:15,731 --> 00:54:19,534 WOMEN'S HEALTH AUTO IMMUNE AND 1252 00:54:19,534 --> 00:54:20,635 IMMUNE-MEDIATED DISEASE WITH 1253 00:54:20,635 --> 00:54:21,737 NIAMS AND DATA SCIENCE STRATEGY 1254 00:54:21,737 --> 00:54:24,072 AND AWARDED THE FIRST LSP 1255 00:54:24,072 --> 00:54:30,512 GRANTEES, ONE OF WHICH WAS A 1256 00:54:30,512 --> 00:54:34,282 FORMER BIRWCH SCHOLAR THAT 1257 00:54:34,282 --> 00:54:35,717 SUPPORTS IN THIS TOPIC AREA TO 1258 00:54:35,717 --> 00:54:38,720 BE IN A POSITION TO LEAD LARGE 1259 00:54:38,720 --> 00:54:43,158 CONE CORE SHA AND IT'S BEEN -- 1260 00:54:43,158 --> 00:54:47,863 CONSORTIA AND IT'S BEEN A 1261 00:54:47,863 --> 00:54:48,363 PRIVILEGE TO WORK WITH 1262 00:54:48,363 --> 00:54:48,997 DR. CRISWELL AND HER TEAM ON THE 1263 00:54:48,997 --> 00:54:49,231 PROGRAM. 1264 00:54:49,231 --> 00:54:49,798 THE MOST RECENT FUNDING 1265 00:54:49,798 --> 00:54:51,333 OPPORTUNITY WE HAD A SECOND ONE 1266 00:54:51,333 --> 00:54:53,335 JUST CLOSED SO STAY TUNED FOR 1267 00:54:53,335 --> 00:54:55,070 MORE NEWS ON THAT. 1268 00:54:55,070 --> 00:54:58,373 WE ALSO WERE EXCITED TO BE ABLE 1269 00:54:58,373 --> 00:55:08,617 TO SHARE SOME 1270 00:55:19,961 --> 00:55:22,597 HIGHLIGHT SUCCESSFUL STRATEGIES 1271 00:55:22,597 --> 00:55:32,174 AND FOR PEOPLE TO LOOK AT 1272 00:55:32,174 --> 00:55:32,808 METHODOLOGIES OR STRATEGIES THAT 1273 00:55:32,808 --> 00:55:33,241 MIGHT WORK IN THEIR 1274 00:55:33,241 --> 00:55:33,575 ORGANIZATION. 1275 00:55:33,575 --> 00:55:34,142 WE'RE SUPPORTING JUNIOR AND 1276 00:55:34,142 --> 00:55:34,776 EARLY STAGE CAREER INVESTIGATORS 1277 00:55:34,776 --> 00:55:35,410 THROUGH TRAVEL AWARDS AT THE 1278 00:55:35,410 --> 00:55:36,044 ORGANIZATION FOR THE STUDY OF 1279 00:55:36,044 --> 00:55:36,445 SEX DIFFERENCES. 1280 00:55:36,445 --> 00:55:40,849 OUR FIRST TRAVEL AWARDEE HERE 1281 00:55:40,849 --> 00:55:43,118 AND CREATED A NEW TRAVEL WARD 1282 00:55:43,118 --> 00:55:45,420 FOR THE MENOPAUSE SOCIETY TI 1283 00:55:45,420 --> 00:55:47,722 MEET AND LOOK FORWARD TO 1284 00:55:47,722 --> 00:55:49,124 ANNOUNCE TWO JUNIOR 1285 00:55:49,124 --> 00:55:50,525 INVESTIGATORS TO ATTEND THE 1286 00:55:50,525 --> 00:55:50,959 MEETING. 1287 00:55:50,959 --> 00:55:55,764 AND ROUNDI IING CLEARS. 1288 00:55:55,764 --> 00:55:57,532 IT WAS DELIGHTFUL TO BE AT THE 1289 00:55:57,532 --> 00:55:58,467 INTERNATIONAL WOMEN'S CONFERENCE 1290 00:55:58,467 --> 00:56:00,969 AND THEIR THEME WAS INQUIRY AND 1291 00:56:00,969 --> 00:56:02,737 INTERVENTION THROUGH SCHOLARSHIP 1292 00:56:02,737 --> 00:56:04,306 AND RESEARCH AND I WAS DELIGHT 1293 00:56:04,306 --> 00:56:08,009 TO BE THERE TO BE ABLE TO SHARE 1294 00:56:08,009 --> 00:56:09,144 ORWH'S STORY AND A LITTLE BIT 1295 00:56:09,144 --> 00:56:10,412 ABOUT MY CAREER. 1296 00:56:10,412 --> 00:56:12,447 UPCOMING EVENTS, I HOPE THAT YOU 1297 00:56:12,447 --> 00:56:18,053 ALL HAVE ON YOUR CALENDAR THE 1298 00:56:18,053 --> 00:56:20,755 EIGHTH ANNUAL VIVIAN PIN 1299 00:56:20,755 --> 00:56:27,696 SYMPOSIUM AND HONORS THE FIRST 1300 00:56:27,696 --> 00:56:33,401 FULL-TIME DIRECTOR SH, VIVIAN P 1301 00:56:33,401 --> 00:56:36,905 SO JOIN US. 1302 00:56:36,905 --> 00:56:38,073 THIS IS ALL VIRTUAL ENTITLED 1303 00:56:38,073 --> 00:56:41,009 SYNERGY IN SCIENCE AND 1304 00:56:41,009 --> 00:56:42,811 INNOVATIONS IN AUTO IMMUNE 1305 00:56:42,811 --> 00:56:43,578 DISEASE RESEARCH AND CARE AND 1306 00:56:43,578 --> 00:56:46,114 REPRESENTS NIH'S OBSERVANCE OF 1307 00:56:46,114 --> 00:56:47,182 NATIONAL WOMEN'S HEALTH WEEK AND 1308 00:56:47,182 --> 00:56:49,951 WE HAVE A VARIETY OF SPECIAL 1309 00:56:49,951 --> 00:56:52,120 ACTIVITIES PLANNED FOR YOU THAT 1310 00:56:52,120 --> 00:56:52,521 WEEK. 1311 00:56:52,521 --> 00:56:54,990 STAY TUNED FOR SPECIAL EVENTS 1312 00:56:54,990 --> 00:56:56,324 AND ANNOUNCEMENTS. 1313 00:56:56,324 --> 00:56:59,094 I MENTIONED MOST ALREADY SO I'LL 1314 00:56:59,094 --> 00:57:02,697 MOVE FORWARD AND ROUND OUT THE 1315 00:57:02,697 --> 00:57:03,598 PRESENTATION TWO MINUTES EARLY. 1316 00:57:03,598 --> 00:57:05,200 IT'S SO IMPORTANT THAT WE SHARE 1317 00:57:05,200 --> 00:57:07,035 THIS INFORMATION WITH YOU AS OUR 1318 00:57:07,035 --> 00:57:09,037 ADVISORY COMMITTEE MEMBERS. 1319 00:57:09,037 --> 00:57:11,573 YOUR RESPONSIBILITY AND ROLE IS 1320 00:57:11,573 --> 00:57:13,708 CRITICAL TO OUR EFFORTS AS WE 1321 00:57:13,708 --> 00:57:15,310 WORK ACROSS NIH WITH ALL THE 1322 00:57:15,310 --> 00:57:19,381 INSTITUTES AND CENTERS TRYING TO 1323 00:57:19,381 --> 00:57:20,415 PROVIDE SCIENTIFIC SYNERGY AND 1324 00:57:20,415 --> 00:57:22,250 ALSO TO BE COMPLIMENTARY TO 1325 00:57:22,250 --> 00:57:23,785 THEIR EFFORTS TO ADVANCE THE 1326 00:57:23,785 --> 00:57:25,187 HEALTH OF WOMEN. 1327 00:57:25,187 --> 00:57:26,454 AS YOU KNOW WE CONSIDER WOMEN'S 1328 00:57:26,454 --> 00:57:27,656 HEALTH EVERYTHING THAT AFFECTS A 1329 00:57:27,656 --> 00:57:29,224 WOMAN FROM HEAD TO TOE INSIDE 1330 00:57:29,224 --> 00:57:31,893 AND OUT ACROSS THE LIFE COURSE 1331 00:57:31,893 --> 00:57:33,094 CONNECTING THE DOTS IS CRITICAL 1332 00:57:33,094 --> 00:57:34,763 AND WE FEEL PRIVILEGED TO BE 1333 00:57:34,763 --> 00:57:36,464 ABLE TO BE ABLE TO WORK ON THAT 1334 00:57:36,464 --> 00:57:36,898 WITH YOU. 1335 00:57:36,898 --> 00:57:38,366 SO THANK YOU SO MUCH FOR YOUR 1336 00:57:38,366 --> 00:57:38,633 ATTENTION. 1337 00:57:38,633 --> 00:57:40,735 I'M GOING COME BACK TO THE TABLE 1338 00:57:40,735 --> 00:57:42,337 AND WE CAN DO QUESTIONS AND 1339 00:57:42,337 --> 00:57:43,905 ANSWERS FROM THERE. 1340 00:57:43,905 --> 00:57:48,243 THANK YOU. 1341 00:57:48,243 --> 00:57:58,787 >> THERE'S TIME FOR ONE OR TWO 1342 00:57:59,487 --> 00:58:07,929 QUESTIONS FOR DR. CLAYTON. 1343 00:58:07,929 --> 00:58:10,465 THERE'S OTHER TIME IN THE FOR 1344 00:58:10,465 --> 00:58:10,865 DISCUSSION TIME. 1345 00:58:10,865 --> 00:58:12,200 >> STEVE HIGGINS. 1346 00:58:12,200 --> 00:58:14,336 I WAS CURIOUS ABOUT THE 1347 00:58:14,336 --> 00:58:15,937 AVAILABILITY OF THE SLIDES TO 1348 00:58:15,937 --> 00:58:16,104 US. 1349 00:58:16,104 --> 00:58:26,214 OKAY. 1350 00:58:26,548 --> 00:58:27,916 >> I DON'T HAVE A QUESTION BUT 1351 00:58:27,916 --> 00:58:29,384 COMMENT WANT TO EXPRESS AS AN 1352 00:58:29,384 --> 00:58:31,786 NIH DIRECTOR HOW GRATEFUL WE ARE 1353 00:58:31,786 --> 00:58:33,188 FOR DR. CLAYTON FOR EVERYTHING 1354 00:58:33,188 --> 00:58:34,522 SHE'S DOING RELATED TO WOMEN'S 1355 00:58:34,522 --> 00:58:34,789 HEALTH. 1356 00:58:34,789 --> 00:58:36,958 A LOT HAS BEEN ASKED OF HER 1357 00:58:36,958 --> 00:58:39,728 RECENTLY AND SHE'S DELIVERED SO 1358 00:58:39,728 --> 00:58:41,763 BEAUTIFULLY AND ON TIME AND IT'S 1359 00:58:41,763 --> 00:58:43,765 BEEN A VERY HEAVY LIFT AND 1360 00:58:43,765 --> 00:58:46,301 YOU'VE DONE A FANTASTIC JOB. 1361 00:58:46,301 --> 00:58:47,669 WE'RE GRATEFUL TO YOU FOR ALL 1362 00:58:47,669 --> 00:58:48,003 YOU'RE DOING. 1363 00:58:48,003 --> 00:58:54,409 >> THANK YOU. 1364 00:58:54,409 --> 00:58:55,677 >> THANK YOU. 1365 00:58:55,677 --> 00:58:56,811 I'LL BE OUR TIME KEEPER AND 1366 00:58:56,811 --> 00:58:57,579 WE'LL MOVE ON. 1367 00:58:57,579 --> 00:59:00,749 THANK YOU, DR. CLAYTON. 1368 00:59:00,749 --> 00:59:07,889 I WOULD NOW LIKE TO WELCOME OUR 1369 00:59:07,889 --> 00:59:10,659 HEALTH SCIENCE POLICY ANALYST AT 1370 00:59:10,659 --> 00:59:11,226 ORWH TO INTRODUCE THE NEXT 1371 00:59:11,226 --> 00:59:11,459 SPEAKER. 1372 00:59:11,459 --> 00:59:18,733 WELCOME. 1373 00:59:18,733 --> 00:59:19,401 >> GOOD MORNING. 1374 00:59:19,401 --> 00:59:23,905 IT'S MY PLEASURE TO INTRODUCE 1375 00:59:23,905 --> 00:59:27,676 DAWN CORBETT THE NIH INCLUSION 1376 00:59:27,676 --> 00:59:29,277 POLICY OFFICER IN THE OFFICE OF 1377 00:59:29,277 --> 00:59:33,181 EXTRAMURAL ACTIVITIES WHERE SHE 1378 00:59:33,181 --> 00:59:34,949 PROVIDES A LEADERSHIP AND 1379 00:59:34,949 --> 00:59:36,785 COORDINATION TO IMPLEMENT 1380 00:59:36,785 --> 00:59:37,852 NIH-WIDE EFFORTS TO ENSURE 1381 00:59:37,852 --> 00:59:39,421 INCLUSION OF WOMEN, MEMBERS OF 1382 00:59:39,421 --> 00:59:41,823 RACIAL AND ETHNIC MINORITIES AND 1383 00:59:41,823 --> 00:59:43,458 INDIVIDUALS ACROSS THE LIFE SPAN 1384 00:59:43,458 --> 00:59:46,628 IN NIH DEFINED CLINICAL 1385 00:59:46,628 --> 00:59:46,895 RESEARCH. 1386 00:59:46,895 --> 00:59:51,132 PRIOR TO JOINING OER IN 2017, 1387 00:59:51,132 --> 00:59:51,900 SHE HELD POSITIONS AT THE 1388 00:59:51,900 --> 00:59:53,868 NATIONAL INSTITUTE OF MENTAL 1389 00:59:53,868 --> 00:59:56,671 HEALTH FOR 14 YEARS WHERE SHE 1390 00:59:56,671 --> 00:59:57,872 OVERSAW PROGRAM ACTIVITY TO 1391 00:59:57,872 --> 00:59:59,874 INCREASE DIVERSITY, EFFICIENCY 1392 00:59:59,874 --> 01:00:02,811 AND TRANSPARENCY IN MENTAL 1393 01:00:02,811 --> 01:00:03,378 HEALTH CLINICAL RESEARCH 1394 01:00:03,378 --> 01:00:03,645 PORTFOLIO. 1395 01:00:03,645 --> 01:00:05,213 SHE HAS A MASTER'S DEGREE IN 1396 01:00:05,213 --> 01:00:07,482 PUBLIC HEALTH FROM THE JOHNS 1397 01:00:07,482 --> 01:00:08,850 HOPKINS BLOOMBERG SCHOOL OF 1398 01:00:08,850 --> 01:00:11,052 PUBLIC HEALTH AND BACHELOR'S 1399 01:00:11,052 --> 01:00:13,254 DEGREE IN POLITICAL SCIENCE FROM 1400 01:00:13,254 --> 01:00:14,589 THE UNIVERSITY OF ILLINOIS 1401 01:00:14,589 --> 01:00:15,957 CHAMPAGNE. 1402 01:00:15,957 --> 01:00:22,864 WELCOME, DAWN. 1403 01:00:22,864 --> 01:00:27,802 >> THANK YOU VERY MUCH. 1404 01:00:27,802 --> 01:00:28,436 I'M DELIGHTED TO BE HERE AGAIN 1405 01:00:28,436 --> 01:00:31,072 AND I WANT TO TALK TO YOU ABOUT 1406 01:00:31,072 --> 01:00:31,906 SOME OF THE THINGS WE'RE DOING 1407 01:00:31,906 --> 01:00:35,410 ON INCLUSION AT NIH RESEARCH. 1408 01:00:35,410 --> 01:00:37,512 JUST TO GET STARTED, I JUST WANT 1409 01:00:37,512 --> 01:00:40,615 TO TAKE A MOMENT TO REVIEW OUR 1410 01:00:40,615 --> 01:00:41,182 INCLUSION POLICY. 1411 01:00:41,182 --> 01:00:42,384 THIS IS SOMETHING I LIKE TO DO 1412 01:00:42,384 --> 01:00:43,985 WITH YOU EVERY YEAR. 1413 01:00:43,985 --> 01:00:45,787 AS A REMINDER OF THE POLICIES 1414 01:00:45,787 --> 01:00:47,756 THAT WE HAVE HERE AT NIH. 1415 01:00:47,756 --> 01:00:50,158 AND THE PURPOSE OF OUR INCLUSION 1416 01:00:50,158 --> 01:00:53,928 POLICIES IS IT ENSURE OR 1417 01:00:53,928 --> 01:00:55,730 RESEARCH IS GENERALIZABLE AND 1418 01:00:55,730 --> 01:00:57,132 THE PEOPLE AFFECT THE CONDITION 1419 01:00:57,132 --> 01:00:59,033 BENEFIT FROM THE RESEARCH WE DO 1420 01:00:59,033 --> 01:00:59,234 HERE. 1421 01:00:59,234 --> 01:01:06,708 SO WE HAVE TWO MAIN INCLAUUSION 1422 01:01:06,708 --> 01:01:10,245 POLICIES ON THE INCLUSION OF 1423 01:01:10,245 --> 01:01:11,613 RACIAL AND ETHNIC MINORITY GROUP 1424 01:01:11,613 --> 01:01:14,549 AND THEY MUST BE INCLUDED IN ALL 1425 01:01:14,549 --> 01:01:15,917 NIH-FUNDED CLINICAL RESEARCH 1426 01:01:15,917 --> 01:01:26,227 STUDIES[NO AUDIO] 1427 01:01:48,349 --> 01:01:49,050 1428 01:01:50,351 --> 01:01:50,552 [NO AUDIO] 1429 01:01:50,552 --> 01:01:50,685 1430 01:01:50,685 --> 01:01:50,885 [NO AUDIO] 1431 01:01:50,885 --> 01:01:51,019 1432 01:01:51,019 --> 01:01:51,219 [NO AUDIO] 1433 01:01:51,219 --> 01:01:51,352 1434 01:01:51,352 --> 01:01:51,553 [NO AUDIO] 1435 01:01:51,553 --> 01:01:51,686 1436 01:01:51,686 --> 01:01:51,886 [NO AUDIO] 1437 01:01:51,886 --> 01:01:51,953 1438 01:01:55,857 --> 01:02:04,098 FOR A SUBSET OF PHASE III 1439 01:02:04,098 --> 01:02:05,200 CLINICAL TRIALS THEY'RE 1440 01:02:05,200 --> 01:02:07,001 FDA-REGULATED PRODUCTS AND HAVE 1441 01:02:07,001 --> 01:02:08,136 TO REPORT THE RESULTS OF THEIR 1442 01:02:08,136 --> 01:02:11,840 ANALYSES BY SEX OR GENDER, RACE 1443 01:02:11,840 --> 01:02:15,510 AND ETHNICITY IN 1444 01:02:15,510 --> 01:02:16,511 CLINICALTRIALS.gov. 1445 01:02:16,511 --> 01:02:18,046 OUR OTHER INCLUSION POLICY IS A 1446 01:02:18,046 --> 01:02:21,082 BIT MORE RECENT, OUR INCLUSION 1447 01:02:21,082 --> 01:02:25,053 ACROSS THE LIFE SPAN REPLACING 1448 01:02:25,053 --> 01:02:26,421 THE CHILDREN INCLUSION POLICY 1449 01:02:26,421 --> 01:02:29,891 AND DUE DATES JANUARY 25, 2019 1450 01:02:29,891 --> 01:02:30,525 OR LATER. 1451 01:02:30,525 --> 01:02:31,259 THIS POLICY REQUIRES INDIVIDUALS 1452 01:02:31,259 --> 01:02:34,295 OF ALL AGES BE INCLUDED IN NIH 1453 01:02:34,295 --> 01:02:37,098 HUMAN SUBJECTS RESEARCH UNLESS 1454 01:02:37,098 --> 01:02:38,099 THERE'S SCIENTIFIC OR ETHICAL 1455 01:02:38,099 --> 01:02:39,834 REASONS NOT TO DO SO. 1456 01:02:39,834 --> 01:02:43,338 LIKE OTHER INCLUSION POLICY, WE 1457 01:02:43,338 --> 01:02:44,939 REQUIRE INCLUSION BE APPROPRIATE 1458 01:02:44,939 --> 01:02:46,808 TO THE SCIENCE AND THAT THERE'S 1459 01:02:46,808 --> 01:02:48,443 A SCIENTIFIC OR ETHICAL REASON 1460 01:02:48,443 --> 01:02:49,143 IF ANY GROUPS ARE EXCLUDED FROM 1461 01:02:49,143 --> 01:02:54,048 OUR RESEARCH. 1462 01:02:54,048 --> 01:02:55,450 POLICY ALSO REQUIRES PARTICIPANT 1463 01:02:55,450 --> 01:02:57,418 DATA AND PROGRESS REPORT. 1464 01:02:57,418 --> 01:03:01,022 IF IN THE PAST YOU SUBMIT THE 1465 01:03:01,022 --> 01:03:02,557 INCLUSION TABLES WITH THE NIH 1466 01:03:02,557 --> 01:03:05,693 GRANT IT'S BEEN REPLACED BY A 1467 01:03:05,693 --> 01:03:08,296 SPREAD SHEET OR CSV FILE WHERE 1468 01:03:08,296 --> 01:03:11,966 THE PROVIDE THE SEX, GENDER, 1469 01:03:11,966 --> 01:03:15,937 RACE, ETHNICITY OR AGE OF EACH 1470 01:03:15,937 --> 01:03:17,872 PARTICIPANT IN THE RESEARCH. 1471 01:03:17,872 --> 01:03:23,211 AND WE REPORT THE DATA EVERY 1472 01:03:23,211 --> 01:03:27,782 YEAR WE REPORT THOSE IN THE 1473 01:03:27,782 --> 01:03:31,986 REPORT WE'LL START MAKING OUR 1474 01:03:31,986 --> 01:03:33,154 DATA BY RCDC CATEGORY AVAILABLE 1475 01:03:33,154 --> 01:03:34,155 ANNUALLY. 1476 01:03:34,155 --> 01:03:36,357 WE STARTED PROVIDING INCLUSION 1477 01:03:36,357 --> 01:03:46,868 DATA BY RCDC RESPONSE TO THE 1478 01:03:47,235 --> 01:03:47,669 21st CENTURY CURES ACT. 1479 01:03:47,669 --> 01:03:48,269 WE HAVE PROVIDED THEM EVERY 1480 01:03:48,269 --> 01:03:50,572 THREE YEARS BUT NOW WILL PROVIDE 1481 01:03:50,572 --> 01:03:51,472 THOSE EVERY YEAR. 1482 01:03:51,472 --> 01:03:57,445 STAY TUNED FOR THE NIH REPORT 1483 01:03:57,445 --> 01:03:58,079 SITE AND WE'LL SEE THE 2023 DATA 1484 01:03:58,079 --> 01:04:00,081 I'M SHARING WITH YOU TODAY THERE 1485 01:04:00,081 --> 01:04:02,450 IN THE NEXT FEW WEEKS. 1486 01:04:02,450 --> 01:04:05,587 MY OFFICE ALSO WORKS ON A NUMBER 1487 01:04:05,587 --> 01:04:15,964 RESOURCES RELATED TO 1488 01:04:52,700 --> 01:04:54,669 PARTICIPANT INCLUSION AND 1489 01:04:54,669 --> 01:04:57,672 INCLUDE CHILDCARE AND MEALS FOR 1490 01:04:57,672 --> 01:04:58,573 PARTICIPANTS. 1491 01:04:58,573 --> 01:05:00,208 REIMBURSEMENT FOR TRAVEL AND 1492 01:05:00,208 --> 01:05:01,275 THESE KINDS OF THINGS. 1493 01:05:01,275 --> 01:05:03,211 NOT EVERYONE IS AWARE OF WHAT 1494 01:05:03,211 --> 01:05:13,888 NIH CAN PAY FOR AND LAUNCHED LA. 1495 01:05:21,396 --> 01:05:24,165 THIS PROJECT WAS LOOKING AT 1496 01:05:24,165 --> 01:05:26,234 ORGANIZATIONAL STRATEGIES TO 1497 01:05:26,234 --> 01:05:28,836 IMPROVE INCLUSION IN CLINICAL 1498 01:05:28,836 --> 01:05:29,103 RESEARCH. 1499 01:05:29,103 --> 01:05:39,647 AND SO AS PART OF THE LAUNCH OF 1500 01:05:41,282 --> 01:05:41,783 THIS PROJECT, IT INCLUDED A 1501 01:05:41,783 --> 01:05:42,383 NUMBER OF RECOMMENDATIONS FOR 1502 01:05:42,383 --> 01:05:42,950 ORGANIZATIONS TO HELP THEM 1503 01:05:42,950 --> 01:05:43,584 IMPROVE INCLUSION ALONG WITH THE 1504 01:05:43,584 --> 01:05:44,118 MATURITY MODEL PROVIDING 1505 01:05:44,118 --> 01:05:44,819 GUIDANCE FROM INSTITUTIONS THAT 1506 01:05:44,819 --> 01:05:45,153 DO RESEARCH. 1507 01:05:45,153 --> 01:05:47,588 EVERYTHING FROM LARGE ACADEMIC 1508 01:05:47,588 --> 01:05:50,458 INSTITUTIONS TO INDUSTRY TO 1509 01:05:50,458 --> 01:05:51,059 COMMUNITY-BASED ORGANIZATIONS. 1510 01:05:51,059 --> 01:05:56,330 AND THE STEPS THEY CAN TAKE TO 1511 01:05:56,330 --> 01:05:57,165 IMPROVE THE INFRASTRUCTURE FOR 1512 01:05:57,165 --> 01:05:57,799 INCLUSION AT THEIR INSTITUTION. 1513 01:05:57,799 --> 01:06:00,468 AND THESE INCLUDE FOUR THEMES 1514 01:06:00,468 --> 01:06:03,104 INCLUDING A DEMONSTRATED 1515 01:06:03,104 --> 01:06:06,174 COMMITMENT FROM LEADERSHIP AND 1516 01:06:06,174 --> 01:06:09,143 INCLUSION AT THE INSTITUTION, 1517 01:06:09,143 --> 01:06:10,545 BI-DIRECTIONAL COMMUNITY 1518 01:06:10,545 --> 01:06:11,179 PARTNERSHIP AND ENGAGEMENT WITH 1519 01:06:11,179 --> 01:06:15,917 PATIENT AND COMMUNITY GROUPS AND 1520 01:06:15,917 --> 01:06:16,551 RESOURCES INCLUDING DEDICATED 1521 01:06:16,551 --> 01:06:26,994 PERSONNEL AND INVESTMENTS. 1522 01:06:52,320 --> 01:06:54,122 -- PROVIDE FLEXIBILITY TO HELP 1523 01:06:54,122 --> 01:06:54,956 ORGANIZATIONS DO THAT. 1524 01:06:54,956 --> 01:06:57,959 THAT'S AVAILABLE ON THE CTTI 1525 01:06:57,959 --> 01:06:58,226 WEBSITE. 1526 01:06:58,226 --> 01:06:59,961 WE'RE PLEASED TO BE A PART OF 1527 01:06:59,961 --> 01:07:01,329 THAT PROJECT WORKING WITH 1528 01:07:01,329 --> 01:07:03,364 COLLEAGUES AT AND ACADEMIA, 1529 01:07:03,364 --> 01:07:08,169 INDUSTRY AND ELSEWHERE. 1530 01:07:08,169 --> 01:07:10,138 WITH THAT QUICK OVERVIEW OF SOME 1531 01:07:10,138 --> 01:07:11,839 HIGHLIGHTS OF WHAT WE'VE BEEN 1532 01:07:11,839 --> 01:07:13,274 DOING IN THE INCLUSION WORLD IN 1533 01:07:13,274 --> 01:07:15,009 THE LAST YEAR I WANT TO SHARE 1534 01:07:15,009 --> 01:07:16,244 OUR FISCAL YEAR 2023 INCLUSION 1535 01:07:16,244 --> 01:07:18,579 DATA. 1536 01:07:18,579 --> 01:07:20,782 SO BEFORE I DIVE INTO THE 1537 01:07:20,782 --> 01:07:21,983 PROPORTIONS, I JUST WANT TO GIVE 1538 01:07:21,983 --> 01:07:24,352 YOU AN IDEA MUCH THE SCOPE OF 1539 01:07:24,352 --> 01:07:26,120 THE DATA THAT YOU'RE LOOKING AT. 1540 01:07:26,120 --> 01:07:30,424 I WON'T GO OVER ALL THE NUMBERS 1541 01:07:30,424 --> 01:07:32,493 BUT I'LL SHARE IS THIS SLIDE 1542 01:07:32,493 --> 01:07:38,366 REPRESENT THE NUMBER OF 1543 01:07:38,366 --> 01:07:39,000 INCLUSION ENROLLMENT REPORTS FOR 1544 01:07:39,000 --> 01:07:39,600 OUR CLINICAL RESEARCH STUDIES 1545 01:07:39,600 --> 01:07:40,168 AND OUR PHASE 3 CLINICAL 1546 01:07:40,168 --> 01:07:40,568 RESEARCH STUDIES. 1547 01:07:40,568 --> 01:07:45,940 SO EVERY STUDY SUBMITS AN 1548 01:07:45,940 --> 01:07:48,609 INCLUSION ENROLLMENT REPORT AND 1549 01:07:48,609 --> 01:07:50,611 HAS INCREASED A BIT SINCE 2021. 1550 01:07:50,611 --> 01:07:52,680 WE HAD ABOUT 26,000 STUDIES 1551 01:07:52,680 --> 01:07:54,215 INCLUDE IN 2021. 1552 01:07:54,215 --> 01:07:57,451 THAT'S JUMPED TO ABOUT 28,000. 1553 01:07:57,451 --> 01:07:59,954 THE DATA THAT HAVE STARTED 1554 01:07:59,954 --> 01:08:01,856 ENROLLING PARTICIPANTS. 1555 01:08:01,856 --> 01:08:03,457 SO WE HAVE SEEN AN INCREASE IN 1556 01:08:03,457 --> 01:08:06,928 THE NUMBER OF STUDIES THAT HAVE 1557 01:08:06,928 --> 01:08:08,162 ENROLLED PARTICIPANTS IN 1558 01:08:08,162 --> 01:08:10,965 RESEARCH NOW THAT FOLKS ARE UP 1559 01:08:10,965 --> 01:08:14,202 AND RUN ARING WITH ENROLLMENT. 1560 01:08:14,202 --> 01:08:16,070 WE HAVE ABOUT 16,500 STUDIES 1561 01:08:16,070 --> 01:08:21,943 REPORTED HERE. 1562 01:08:21,943 --> 01:08:25,980 AND A TREND IN RESEARCH IS MOST 1563 01:08:25,980 --> 01:08:27,982 ARE U.S. SITES AND HAVE A SMALL 1564 01:08:27,982 --> 01:08:29,917 PROPORTIONATE NON-U.S. SITES AND 1565 01:08:29,917 --> 01:08:32,019 HAVE MORE FEMALE ONLY THAN MALE 1566 01:08:32,019 --> 01:08:35,389 ONLY STUDIES. 1567 01:08:35,389 --> 01:08:41,629 YOU SEE IN THE RECENT FISCAL 1568 01:08:41,629 --> 01:08:49,003 YEAR ONLY 750 MALE ONLY STUDIES. 1569 01:08:49,003 --> 01:08:51,873 AND THEY INCLUDE ALL SEXES OR 1570 01:08:51,873 --> 01:08:53,107 GENDERS. 1571 01:08:53,107 --> 01:08:55,142 WHEN WE LOOK AT THE PHASE III 1572 01:08:55,142 --> 01:08:56,277 COLLABORATES IT'S A SMALLER 1573 01:08:56,277 --> 01:08:57,945 UNIVERSE THAN THE NIH CLINICAL 1574 01:08:57,945 --> 01:08:58,546 RESEARCH. 1575 01:08:58,546 --> 01:08:59,881 OPPOSED TO THE 28,000 THAT WE 1576 01:08:59,881 --> 01:09:02,650 HAD IN CLINICAL RESEARCH ARE IN 1577 01:09:02,650 --> 01:09:13,194 2023, THEY HAD ABOUT 1200 NIH WE 1578 01:09:27,975 --> 01:09:31,412 HAVE 800 TRIALS. 1579 01:09:31,412 --> 01:09:41,722 WE HAVE ABOUT 176. 1580 01:09:48,629 --> 01:09:51,899 AND SOME REPORTED ONLY FEMALES 1581 01:09:51,899 --> 01:09:56,170 OPPOSED TO 40 INCLUDING ONLY 1582 01:09:56,170 --> 01:09:57,705 MALES. 1583 01:09:57,705 --> 01:10:00,441 THIS SLIDE SHOWS THE NUMBER OF 1584 01:10:00,441 --> 01:10:03,010 PARTICIPANTS THAT WE'RE LOOKING 1585 01:10:03,010 --> 01:10:03,811 AT IN THE DATA. 1586 01:10:03,811 --> 01:10:07,214 I PROVIDED THREE YEARS HERE FOR 1587 01:10:07,214 --> 01:10:08,149 COMPARISON BUT WE'LL FOCUS ON 1588 01:10:08,149 --> 01:10:09,483 THE 2023 DATA. 1589 01:10:09,483 --> 01:10:11,252 SO OUR TOTAL ENROLL MANY THIS 1590 01:10:11,252 --> 01:10:14,322 YEAR IS PRETTY TYPICAL. 1591 01:10:14,322 --> 01:10:15,790 WE HAVE ABOUT 12 MILLION 1592 01:10:15,790 --> 01:10:16,390 PARTICIPANTS IN OUR RESEARCH. 1593 01:10:16,390 --> 01:10:20,194 ABOUT MILLION ARE 1594 01:10:20,194 --> 01:10:21,762 U.S. PARTICIPANTS OR ABOUT 1595 01:10:21,762 --> 01:10:23,331 THREE-QUARTERS OF THOSE AND A 1596 01:10:23,331 --> 01:10:25,700 QUARTER OF THE PARTICIPANTS ARE 1597 01:10:25,700 --> 01:10:28,703 FROM OUTSIDE THE U.S. WHEN WE'RE 1598 01:10:28,703 --> 01:10:32,540 LOOKING AT OUR CLINICAL 1599 01:10:32,540 --> 01:10:33,107 RESEARCH. 1600 01:10:33,107 --> 01:10:34,442 LOOKING AT PHASE III CLINICAL 1601 01:10:34,442 --> 01:10:35,543 TRIALS THE NUMBERS ARE DIFFERENT 1602 01:10:35,543 --> 01:10:39,647 ABOUT 800,000 PATIENTS IN OUR 1603 01:10:39,647 --> 01:10:41,148 PHASE III CLINICAL TRIALS IN 1604 01:10:41,148 --> 01:10:43,017 FISCAL YEAR 2023. 1605 01:10:43,017 --> 01:10:44,685 WE HAVE FEWER U.S.-ONLY 1606 01:10:44,685 --> 01:10:46,053 PARTICIPANTS WHEN WE'RE LOOKING 1607 01:10:46,053 --> 01:10:52,426 AT A PROPORTION OF 62% IN THE 1608 01:10:52,426 --> 01:11:02,870 U.S. AND 38% ARE NON-U.S. 1609 01:11:05,873 --> 01:11:07,908 AND RESEARCH ENROLLMENT BY SEX 1610 01:11:07,908 --> 01:11:14,415 OR GENDER FOR FISCAL YEARS 2022 1611 01:11:14,415 --> 01:11:15,983 AND 2023 AND THEY'RE ADJUSTED 1612 01:11:15,983 --> 01:11:18,753 BECAUSE OF ONE STUDY WITH 86 1613 01:11:18,753 --> 01:11:19,353 MILLION PARTICIPANTS AND WE 1614 01:11:19,353 --> 01:11:20,187 EXCLUDED THAT HERE. 1615 01:11:20,187 --> 01:11:22,890 THE TRENDS BY SEX OR GENDER HAVE 1616 01:11:22,890 --> 01:11:23,924 BEEN FAIRLY STUDY OVER A NUMBER 1617 01:11:23,924 --> 01:11:24,892 OF YEARS. 1618 01:11:24,892 --> 01:11:25,893 I'VE BEEN DOING THIS ABOUT 20 1619 01:11:25,893 --> 01:11:28,863 YEARS AND IN MOST OF THOSE YEARS 1620 01:11:28,863 --> 01:11:30,865 WE SEE MORE FEMALE PARTICIPANTS 1621 01:11:30,865 --> 01:11:31,932 THAN MALE PARTICIPANTS. 1622 01:11:31,932 --> 01:11:41,542 THAT STILL HOLDS TRUE. 1623 01:11:41,542 --> 01:11:47,248 AND THERE WERE 26% IN 2022 AND 1624 01:11:47,248 --> 01:11:57,591 AGAIN 56.5% IN 2023. 1625 01:11:58,459 --> 01:12:01,262 WHEN WE LOOK AT ENROLLMENT IN 1626 01:12:01,262 --> 01:12:02,563 PHASE III CLINICAL TRIALS WE SEE 1627 01:12:02,563 --> 01:12:07,401 A GREATER PROPORTION OF WOMEN IN 1628 01:12:07,401 --> 01:12:08,869 PHASE III CLINICAL TRIALS THAN 1629 01:12:08,869 --> 01:12:11,639 RESEARCH AS A WHOLE. 1630 01:12:11,639 --> 01:12:18,813 WE HAVE MORE FEMALE ONLY NIH 1631 01:12:18,813 --> 01:12:20,448 PHASE III TRIALS AND EXPLAINS 1632 01:12:20,448 --> 01:12:21,048 THE DIFFERENCE. 1633 01:12:21,048 --> 01:12:26,353 WE'RE UP TO IN 2023 TWO-THIRDS 1634 01:12:26,353 --> 01:12:30,191 OF PARTICIPANTS IN OUR CLINICAL 1635 01:12:30,191 --> 01:12:31,559 TRIALS IDENTIFIED AS FEMALE. 1636 01:12:31,559 --> 01:12:35,463 THAT'S UP FROM 61% IN FISCAL 1637 01:12:35,463 --> 01:12:43,370 YEAR '21. 1638 01:12:43,370 --> 01:12:45,539 IF WE LOOK AT DATA BY RACE IT'S 1639 01:12:45,539 --> 01:12:47,641 BEEN TRENDS WITH NOTABLE 1640 01:12:47,641 --> 01:12:48,342 EXCEPTIONS. 1641 01:12:48,342 --> 01:12:50,945 THE LARGEST RACIAL GROUP 1642 01:12:50,945 --> 01:12:52,947 REPORTED IS WHITE WHICH HAS BEEN 1643 01:12:52,947 --> 01:12:54,615 CONSISTENT OVER THE YEARS THOUGH 1644 01:12:54,615 --> 01:12:57,451 THE NUMBER HAS DECREASED. 1645 01:12:57,451 --> 01:13:01,088 IT'S ABOUT 53% IN 2021 INCREASE 1646 01:13:01,088 --> 01:13:03,591 TO 58% IN 2022 AFTER WE ADJUSTED 1647 01:13:03,591 --> 01:13:04,859 THE DATA AND NOW 46% OF 1648 01:13:04,859 --> 01:13:08,562 PARTICIPANTS. 1649 01:13:08,562 --> 01:13:09,130 IDENTIFIED BY WHITE. 1650 01:13:09,130 --> 01:13:12,133 THE LARGEST GROUP IS BLACK OR 1651 01:13:12,133 --> 01:13:12,666 AFRICAN AMERICAN. 1652 01:13:12,666 --> 01:13:16,537 THAT HAS RANGED FROM 18% TO 19% 1653 01:13:16,537 --> 01:13:19,106 IN 2023 NOW ABOUT 19% OF 1654 01:13:19,106 --> 01:13:25,045 PARTICIPANTS IDENTIFIED AS BLACK 1655 01:13:25,045 --> 01:13:27,882 OR AFRICAN AMERICAN AND THE NEXT 1656 01:13:27,882 --> 01:13:32,753 GROUP IS ASIAN ABOUT 12% IN 2021 1657 01:13:32,753 --> 01:13:34,121 DECREASED LAST YEAR AND BACK UP 1658 01:13:34,121 --> 01:13:44,398 TO 11% IN 2023. 1659 01:13:52,573 --> 01:13:55,042 WE HAVE PARTICIPATION FROM 1660 01:13:55,042 --> 01:13:58,145 OTHERS DECREASED A BIT IN FISCAL 1661 01:13:58,145 --> 01:13:58,913 YEAR 2023. 1662 01:13:58,913 --> 01:14:01,081 MORE THAN ONE RACE HAS HELD 1663 01:14:01,081 --> 01:14:05,019 FAIRLY STEADY BETWEEN 2% AND 3% 1664 01:14:05,019 --> 01:14:06,453 NOW AT 2.6%. 1665 01:14:06,453 --> 01:14:07,421 ANOTHER CHANGE WE'VE SEEN ACROSS 1666 01:14:07,421 --> 01:14:09,290 THE BOARD IN OUR DATA IS 1667 01:14:09,290 --> 01:14:11,926 INCREASE IN UNKNOWN OR NOT 1668 01:14:11,926 --> 01:14:12,826 REPORTED. 1669 01:14:12,826 --> 01:14:15,729 YOU CAN SEE THERE IN THE TOP 1670 01:14:15,729 --> 01:14:19,867 BLUE SECTION ABOUT 18% OF OUR 1671 01:14:19,867 --> 01:14:22,136 PARTICIPANTS DID NOT IDENTIFY A 1672 01:14:22,136 --> 01:14:27,041 RACE AND SO YOU MAY HAVE HEARD 1673 01:14:27,041 --> 01:14:28,876 OMB RECENTLY ANNOUNCED NEW 1674 01:14:28,876 --> 01:14:31,946 ETHNIC AND RACIAL CATEGORIES ON 1675 01:14:31,946 --> 01:14:34,448 MARCH 28 WHICH NIH WILL BE 1676 01:14:34,448 --> 01:14:36,250 IMPLEMENTING OVER THE NEXT 1677 01:14:36,250 --> 01:14:39,887 SEVERAL YEARS. 1678 01:14:39,887 --> 01:14:44,358 WE'LL SEE HOW IT AFFECTS 1679 01:14:44,358 --> 01:14:46,227 NOT-REPORTED INDIVIDUALS IN 1680 01:14:46,227 --> 01:14:48,229 STUDIES INVOLVING E.H.R.s. 1681 01:14:48,229 --> 01:14:53,000 WHEN WE LOOK AT THE NIH DEFINED 1682 01:14:53,000 --> 01:14:54,034 PHASE III CLINICAL TRIAL WE SIGH 1683 01:14:54,034 --> 01:14:55,903 A SMALLER PERCENTAGE OF UNKNOWNS 1684 01:14:55,903 --> 01:14:58,239 AND WE'RE LOOKING AT A SMALLER 1685 01:14:58,239 --> 01:15:01,342 SET OF STUDIES SO DATA JUMPS. 1686 01:15:01,342 --> 01:15:04,245 THE LARGEST RACIAL CATEGORY WAS 1687 01:15:04,245 --> 01:15:07,448 WHITE, 50.5% IN FISCAL YEAR 1688 01:15:07,448 --> 01:15:07,848 2023. 1689 01:15:07,848 --> 01:15:09,617 SO THAT'S DOWN A BIT FROM 1690 01:15:09,617 --> 01:15:11,418 PREVIOUS YEARS. 1691 01:15:11,418 --> 01:15:14,722 THE NEXT LARGEST RACIAL GROUP 1692 01:15:14,722 --> 01:15:15,556 WAS BLACK OR AFRICAN AMERICAN. 1693 01:15:15,556 --> 01:15:17,091 ABOUT A QUARTER OF PARTICIPANTS 1694 01:15:17,091 --> 01:15:19,793 NOW IDENTIFY AS BLACK OR AFRICAN 1695 01:15:19,793 --> 01:15:21,362 AMERICAN AS OF FISCAL YEAR 2023. 1696 01:15:21,362 --> 01:15:26,667 THAT IS FOLLOWED BY ASIAN AND 1697 01:15:26,667 --> 01:15:30,838 12% OF PARTICIPANTS IDENTIFIED 1698 01:15:30,838 --> 01:15:31,905 AS ASIAN IN 2023 AND THAT'S 1699 01:15:31,905 --> 01:15:34,441 FLUCTUATED FROM 18% IN 2021 TO 1700 01:15:34,441 --> 01:15:39,880 7% NOW BACK UP TO 12%. 1701 01:15:39,880 --> 01:15:41,715 SMALLER RACIAL GROUPS INCLUDE 1702 01:15:41,715 --> 01:15:43,484 AMERICAN INDIAN OR ALASKAN 1703 01:15:43,484 --> 01:15:46,553 NATIVE INCREASED FROM 1.1%. 1704 01:15:46,553 --> 01:15:47,254 NATIVE HAWAIIAN AND OTHER 1705 01:15:47,254 --> 01:15:51,125 PACIFIC ISLANDER DECREASED FROM 1706 01:15:57,598 --> 01:15:59,967 .2% TO .1% AND NOT REPORTED IS 1707 01:15:59,967 --> 01:16:03,904 SMALLER THAN OUR OVER ALL 1708 01:16:03,904 --> 01:16:06,106 CLINICAL RESEARCH ABOUT 9% OF 1709 01:16:06,106 --> 01:16:07,908 PARTICIPANTS WERE UNKNOWN OR NOT 1710 01:16:07,908 --> 01:16:08,876 REPORTED. 1711 01:16:08,876 --> 01:16:11,912 LOOKING AT ETHNICITY, THE 1712 01:16:11,912 --> 01:16:14,915 NUMBERS HAVE INCREASED A BIT FOR 1713 01:16:14,915 --> 01:16:19,119 HISPANIC OR LATINO PARTICIPANTS 1714 01:16:19,119 --> 01:16:23,991 SINCE 2021, 10% UP TO 12% IN 1715 01:16:23,991 --> 01:16:24,958 FISCAL 2023. 1716 01:16:24,958 --> 01:16:28,962 WE ALSO HAVE SEEN AN INCREASE IN 1717 01:16:28,962 --> 01:16:32,199 THE PROPORTION OF UNREPORTED 1718 01:16:32,199 --> 01:16:33,701 ABOUT 10% ALSO IN 2021 NOW UP TO 1719 01:16:33,701 --> 01:16:35,936 14% IN 2023. 1720 01:16:35,936 --> 01:16:37,338 AND AGAIN WE LOOK FORWARD TO 1721 01:16:37,338 --> 01:16:40,207 SEEING HOW THE CHANGES IN OMB 1722 01:16:40,207 --> 01:16:42,009 CATEGORIES MAY AFFECT THE 1723 01:16:42,009 --> 01:16:42,876 NUMBERS. 1724 01:16:42,876 --> 01:16:47,948 LOOKING AT NIH DEFINED PHASE III 1725 01:16:47,948 --> 01:16:50,150 CLINICAL TRIALS THE NUMBERS JUMP 1726 01:16:50,150 --> 01:16:52,319 AROUND A BIT AND THIS IS LARGELY 1727 01:16:52,319 --> 01:16:55,255 DUE TO ONE STUDY NOT REPORTED IN 1728 01:16:55,255 --> 01:16:57,958 2022. 1729 01:16:57,958 --> 01:16:58,525 SO THE 2022 DATA LOOK MORE 1730 01:16:58,525 --> 01:16:59,259 TYPICAL. 1731 01:16:59,259 --> 01:17:03,063 YOU SEE A CHANGE FROM 31% TO 15% 1732 01:17:03,063 --> 01:17:06,767 IN 2022 AND THAT'S BUMPED UP TO 1733 01:17:06,767 --> 01:17:10,738 16% IN FISCAL 2023. 1734 01:17:10,738 --> 01:17:16,310 I MENTIONED OUR INCLUSION ACROSS 1735 01:17:16,310 --> 01:17:19,446 THE LIFE SPAN POLICY IS PART OF 1736 01:17:19,446 --> 01:17:23,250 THE REQUIREMENT WE BEGAN 1737 01:17:23,250 --> 01:17:26,720 REQUIRING AGE AT ENROLLMENT. 1738 01:17:26,720 --> 01:17:27,654 THIS IS A SUBSET OF OUR DATA 1739 01:17:27,654 --> 01:17:27,821 NOW. 1740 01:17:27,821 --> 01:17:29,523 NOT ALL OUR STUDIES ARE ACROSS 1741 01:17:29,523 --> 01:17:30,657 THE LIFE SPAN BUT CERTAINLY MORE 1742 01:17:30,657 --> 01:17:31,225 ARE NOW. 1743 01:17:31,225 --> 01:17:34,661 WE CAN NOW LOOK AT THE AGE OF 1744 01:17:34,661 --> 01:17:38,198 OUR PARTICIPANTS BY AGE GROUP. 1745 01:17:38,198 --> 01:17:40,200 SO THIS SLIDE SHOWS SOME OF AGE 1746 01:17:40,200 --> 01:17:41,502 GROUPS OF CHILDREN ADULTS AND 1747 01:17:41,502 --> 01:17:45,038 OLDER ADULTS AND UNKNOWN OR NOT 1748 01:17:45,038 --> 01:17:45,305 REPORTED. 1749 01:17:45,305 --> 01:17:55,516 NO SURPRISE, 1750 01:18:22,176 --> 01:18:24,678 ABOUT 20% DOWN TO ABOUT 9%. 1751 01:18:24,678 --> 01:18:25,846 AGAIN, WE'LL LOOK FORWARD TO 1752 01:18:25,846 --> 01:18:27,881 SEEING WHAT THE TRENDS LOOK LIKE 1753 01:18:27,881 --> 01:18:34,655 OVER TIME. 1754 01:18:34,655 --> 01:18:46,099 OLDER ADULTS FS FLUC SHUATED AN 1755 01:18:52,539 --> 01:18:57,845 LOOKED AT THE DEVELOPING THE 1756 01:18:57,845 --> 01:19:08,355 POLICY AND WE HAVE A SMALLER 1757 01:19:08,355 --> 01:19:09,923 NUMBER OF PARTICIPANTS IN OUR 1758 01:19:09,923 --> 01:19:11,225 MIDDLE AGE GROUPS GETTING TO THE 1759 01:19:11,225 --> 01:19:12,392 UPPER AGE OF THE LIFE SPAN WHEN 1760 01:19:12,392 --> 01:19:15,762 WE LOOK AT INDIVIDUALS OVER 80. 1761 01:19:15,762 --> 01:19:18,465 SO WITH THAT I THINK WE HAVE A 1762 01:19:18,465 --> 01:19:19,867 FEW MINUTES IF THERE ARE ANY 1763 01:19:19,867 --> 01:19:20,133 QUESTIONS. 1764 01:19:20,133 --> 01:19:23,904 I WOULD BE HAPPY TO ADDRESS 1765 01:19:23,904 --> 01:19:25,339 THEM. 1766 01:19:25,339 --> 01:19:27,841 >> THANK YOU VERY MUCH, MS. 1767 01:19:27,841 --> 01:19:28,075 CORBETT. 1768 01:19:28,075 --> 01:19:28,909 NOW THE FLOOR'S OPEN FOR 1769 01:19:28,909 --> 01:19:35,549 QUESTIONS AND COMMENTS. 1770 01:19:35,549 --> 01:19:37,484 DR. SIMON. 1771 01:19:37,484 --> 01:19:39,887 >> THANK YOU FOR THAT REPORT. 1772 01:19:39,887 --> 01:19:40,754 EXCELLENT WORK. 1773 01:19:40,754 --> 01:19:44,224 SO WITH RESPECT TO ALLOWING 1774 01:19:44,224 --> 01:19:46,593 STUDIES TO DECLARE GENDER OR SEX 1775 01:19:46,593 --> 01:19:49,162 AND YOU PUT THEM ALL TOGETHER IF 1776 01:19:49,162 --> 01:19:51,465 THERE'S GOING TO BE SOME MOVE 1777 01:19:51,465 --> 01:19:54,501 TOWARDS SEPARATING THOSE TWO 1778 01:19:54,501 --> 01:19:56,370 QUESTIONS LIKE WHAT IS THE SEX 1779 01:19:56,370 --> 01:19:57,804 OF YOUR PARTICIPANTS AND WHAT 1780 01:19:57,804 --> 01:20:01,408 ARE THE GENDER IDENTITIES OF 1781 01:20:01,408 --> 01:20:01,842 YOUR PARTICIPANTS. 1782 01:20:01,842 --> 01:20:03,410 >> THANK YOU FOR ASKING THAT 1783 01:20:03,410 --> 01:20:03,677 QUESTION. 1784 01:20:03,677 --> 01:20:05,112 JUST TO CLARIFY FOR FOLKS IN THE 1785 01:20:05,112 --> 01:20:07,447 ROOM WHO MAY NOT BE AWARE, THE 1786 01:20:07,447 --> 01:20:09,550 POLICY DOES ALLOW INVESTIGATORS 1787 01:20:09,550 --> 01:20:11,418 TO REPORT EITHER SEX OR GENDER 1788 01:20:11,418 --> 01:20:13,654 DEPENDING ON WHAT'S MOST 1789 01:20:13,654 --> 01:20:17,457 RELEVANT TO THE SCIENTIFIC 1790 01:20:17,457 --> 01:20:17,891 QUESTION. 1791 01:20:17,891 --> 01:20:19,359 WE DO CURRENTLY PUT THOSE 1792 01:20:19,359 --> 01:20:21,228 TOGETHER INTO ONE CATEGORY AND 1793 01:20:21,228 --> 01:20:22,229 THAT'S CERTAINLY SOMETHING 1794 01:20:22,229 --> 01:20:24,298 THAT'S BEEN UNDER DISCUSSION AT 1795 01:20:24,298 --> 01:20:24,598 NIH. 1796 01:20:24,598 --> 01:20:26,767 WE RECOGNIZE THE DIFFERENCE 1797 01:20:26,767 --> 01:20:29,136 BETWEEN SEX AND GENDER, OUR 1798 01:20:29,136 --> 01:20:30,003 UNDERSTANDING HAS EVOLVES SINCE 1799 01:20:30,003 --> 01:20:32,739 THE POLICY WAS CREATED IN 1994 1800 01:20:32,739 --> 01:20:34,441 AND WE CERTAINLY WANT TO 1801 01:20:34,441 --> 01:20:35,676 UNDERSTAND IF STUDIES ARE 1802 01:20:35,676 --> 01:20:37,911 LOOKING AT SEX OR GENDER. 1803 01:20:37,911 --> 01:20:39,913 THAT'S SOMETHING THAT'S 1804 01:20:39,913 --> 01:20:43,483 CURRENTLY UNDER DISCUSSION. 1805 01:20:43,483 --> 01:20:46,486 >> ANDREA JONES. 1806 01:20:46,486 --> 01:20:47,688 WONDERING IF YOU WANTED TO SAY 1807 01:20:47,688 --> 01:20:50,357 MORE ABOUT THE INSTITUTES DOING 1808 01:20:50,357 --> 01:20:52,125 INCREDIBLY WELL WITH BEING ABLE 1809 01:20:52,125 --> 01:20:56,597 TO RECRUIT AND RETAIN 1810 01:20:56,597 --> 01:20:58,265 PARTICIPANTS AND HOW THEY'RE 1811 01:20:58,265 --> 01:20:59,600 SHARING THEIR DATA ANY SUCCESS 1812 01:20:59,600 --> 01:20:59,833 STORIES. 1813 01:20:59,833 --> 01:21:03,403 >> ABSOLUTELY. 1814 01:21:03,403 --> 01:21:05,539 WE HAVE SO MANY GROUPS DOING 1815 01:21:05,539 --> 01:21:05,739 WELL. 1816 01:21:05,739 --> 01:21:09,009 ONE YOU MAY HAVE HEARD ABOUT IS 1817 01:21:09,009 --> 01:21:11,411 SEAL OR COMMUNITY ENGAGEMENT 1818 01:21:11,411 --> 01:21:13,513 ALLIANCE STARTED IN THE COVID-19 1819 01:21:13,513 --> 01:21:14,815 PANDEMIC AND NOW CONTINUING 1820 01:21:14,815 --> 01:21:15,248 BEYOND THAT. 1821 01:21:15,248 --> 01:21:17,351 THEY'VE DONE A LOT OF OUTREACH 1822 01:21:17,351 --> 01:21:17,751 WITH COMMUNITIES. 1823 01:21:17,751 --> 01:21:22,889 THEY'VE DONE WEBINARS, RADIO, A 1824 01:21:22,889 --> 01:21:23,890 LOT OF OUTREACH AND THAT 1825 01:21:23,890 --> 01:21:27,494 CONTINUES AND LOOKING AT OTHER 1826 01:21:27,494 --> 01:21:29,029 CONDITIONS OTHER THAN COVID-19. 1827 01:21:29,029 --> 01:21:33,000 CERTAINLY OUR CTSA'S IS AN 1828 01:21:33,000 --> 01:21:34,134 EXAMPLE OF HOW COMMUNITY 1829 01:21:34,134 --> 01:21:36,169 ENGAGEMENT CAN HELP WITH 1830 01:21:36,169 --> 01:21:37,704 INCLUSION OVERTIME AND THAT 1831 01:21:37,704 --> 01:21:39,806 GROUP CONTINUES A NUMBER OF 1832 01:21:39,806 --> 01:21:40,140 EFFORTS. 1833 01:21:40,140 --> 01:21:41,742 THE TRIAL INNOVATION NETWORK HAS 1834 01:21:41,742 --> 01:21:43,710 CREATED A NUMBER OF RESOURCES 1835 01:21:43,710 --> 01:21:45,112 THAT THEY MAKE PUBLICALLY 1836 01:21:45,112 --> 01:21:46,947 AVAILABLE ON THEIR WEBSITE. 1837 01:21:46,947 --> 01:21:49,950 SO ANY OF THAT CAN GO TO THE 1838 01:21:49,950 --> 01:21:52,486 WEBSITE AND USE THE TOOLS THEY 1839 01:21:52,486 --> 01:21:52,686 HAVE. 1840 01:21:52,686 --> 01:21:55,489 SO WE'RE TRYING TO BUILD THAT 1841 01:21:55,489 --> 01:21:57,758 INFRASTRUCTURE AND HELP OTHERS 1842 01:21:57,758 --> 01:21:59,860 REPLICATE THOSE SUCCESSES. 1843 01:21:59,860 --> 01:22:02,129 REALLY ACROSS INSTITUTES I THINK 1844 01:22:02,129 --> 01:22:04,431 WE'VE SEEN A REAL DEDICATION AND 1845 01:22:04,431 --> 01:22:05,732 COMMITMENT TO INCLUSION AND 1846 01:22:05,732 --> 01:22:07,901 WE'VE SEEN ESPECIALLY IN LIGHT 1847 01:22:07,901 --> 01:22:09,436 OF THE PANDEMIC WE HAVE SEEN 1848 01:22:09,436 --> 01:22:12,639 GROUPS INCREASINGLY FOCUS ON 1849 01:22:12,639 --> 01:22:13,040 THIS. 1850 01:22:13,040 --> 01:22:17,277 I WILL SAY MY BIAS COMING FROM 1851 01:22:17,277 --> 01:22:19,479 NIMHD IS ON EVALUATION. 1852 01:22:19,479 --> 01:22:23,316 AND I WILL SAY THAT ACROSS NIH 1853 01:22:23,316 --> 01:22:24,017 SOME INSTITUTES DO THIS A LITTLE 1854 01:22:24,017 --> 01:22:26,019 BIT DIFFERENTLY BUT I THINK WHAT 1855 01:22:26,019 --> 01:22:28,488 MAKES SUCCESSFUL INCLUSION IS 1856 01:22:28,488 --> 01:22:33,026 CONTINUALLY EVALUATING IT AND 1857 01:22:33,026 --> 01:22:33,927 HAVING CONVERSATIONS WITH 1858 01:22:33,927 --> 01:22:35,128 PROGRAM OFFICERS AND 1859 01:22:35,128 --> 01:22:36,029 INSTITUTIONS HAVING THEIR OWN 1860 01:22:36,029 --> 01:22:37,597 METHOD OF ACCOUNTABILITY AND I 1861 01:22:37,597 --> 01:22:42,102 THINK WHEN WE LOOK AT INCLUSION 1862 01:22:42,102 --> 01:22:43,236 REGULARLY AND ADJUST WHEN THINGS 1863 01:22:43,236 --> 01:22:45,372 AREN'T GOING AS PLANNED THAT'S 1864 01:22:45,372 --> 01:22:47,908 WHEN WE SEE THEM AS SUCCESS 1865 01:22:47,908 --> 01:22:51,078 ACROSS NIH. 1866 01:22:51,078 --> 01:22:51,678 >> THANK YOU. 1867 01:22:51,678 --> 01:22:53,213 AND FOLLOWING UP WITH THE 1868 01:22:53,213 --> 01:22:56,049 EVALUATION YOU MENTIONED IN 1869 01:22:56,049 --> 01:23:00,554 2022RPPRs HAVE TO DO THE 1870 01:23:00,554 --> 01:23:00,887 ANALYSIS. 1871 01:23:00,887 --> 01:23:01,922 HOW HAS COMPLIANCE WITHIN GOING 1872 01:23:01,922 --> 01:23:03,056 AND ARE THERE PARTICULAR 1873 01:23:03,056 --> 01:23:03,890 CHALLENGES YOU WANT TO HIGHLIGHT 1874 01:23:03,890 --> 01:23:07,260 YOU MAY BE ABLE TO THINK ABOUT. 1875 01:23:07,260 --> 01:23:10,530 >> AND SO AS I MENTIONED WE PUT 1876 01:23:10,530 --> 01:23:14,935 OUT A CLARIFICATION IN 2022 THAT 1877 01:23:14,935 --> 01:23:20,474 IS YOU'RE DOING AN NIH DEFINED 1878 01:23:20,474 --> 01:23:23,877 PHASE III CLINICAL TRIAL YOU 1879 01:23:23,877 --> 01:23:26,913 HAVE TO PUT RACE AND SEX AND 1880 01:23:26,913 --> 01:23:29,316 GENDER AND ETHNICITY IN YOUR 1881 01:23:29,316 --> 01:23:29,616 OUTCOMES. 1882 01:23:29,616 --> 01:23:31,318 IT'S MAKING SURE FOLKS ARE AWARE 1883 01:23:31,318 --> 01:23:33,086 OF THE REQUIREMENT THAT IS ONE 1884 01:23:33,086 --> 01:23:34,054 PURPOSE OF THE CLARIFICATION TO 1885 01:23:34,054 --> 01:23:35,889 GET THAT OUT THERE WHEN WE SEE 1886 01:23:35,889 --> 01:23:37,891 IF THESE ANALYSES ARE NOT 1887 01:23:37,891 --> 01:23:39,326 INCLUDED WE NOTIFY PROGRAM 1888 01:23:39,326 --> 01:23:40,594 OFFICER WHO WILL THEN REACH OUT 1889 01:23:40,594 --> 01:23:44,097 TO THE INVESTIGATOR TO DO THAT. 1890 01:23:44,097 --> 01:23:46,299 SO WE'RE SEEING INCREASING 1891 01:23:46,299 --> 01:23:48,502 COMPLIANCE WITH INCREASED 1892 01:23:48,502 --> 01:23:49,402 AWARENESS. 1893 01:23:49,402 --> 01:23:51,471 WITH ALL THESE WE NEED THE 1894 01:23:51,471 --> 01:23:52,939 ENTIRE SCIENTIFIC COMMUNITY TO 1895 01:23:52,939 --> 01:23:54,407 LET PEOPLE KNOW ABOUT THE 1896 01:23:54,407 --> 01:23:55,041 REQUIREMENTS TO MAKE COMPLIANCE 1897 01:23:55,041 --> 01:24:04,584 EASIER. 1898 01:24:04,584 --> 01:24:07,988 >> IS THERE ANY MOVEMENT TOWARDS 1899 01:24:07,988 --> 01:24:09,723 DISAGGREGATING THE GROUP WHICH 1900 01:24:09,723 --> 01:24:14,161 IS VERY HETEROGENOUS WITH REGARD 1901 01:24:14,161 --> 01:24:15,028 TO THE OUTCOMES. 1902 01:24:15,028 --> 01:24:19,833 >> THIS WAS INCLUDED ON MARCH 1903 01:24:19,833 --> 01:24:23,670 28, OBM ANNOUNCE THE NEW 1904 01:24:23,670 --> 01:24:26,239 GUIDELINES AND AMONG THEM 1905 01:24:26,239 --> 01:24:28,909 INCLUDE DISAGGREGATED CATEGORIES 1906 01:24:28,909 --> 01:24:30,010 FOR FEDERAL AGENCIES AND THERE 1907 01:24:30,010 --> 01:24:34,748 ARE A NUMBER OF GROUPS INCLUDING 1908 01:24:34,748 --> 01:24:36,683 CHINESE, FILIPINO AND INDIAN, 1909 01:24:36,683 --> 01:24:36,950 ETCETERA. 1910 01:24:36,950 --> 01:24:38,585 THAT'S THE CASE WITH ALMOST ALL 1911 01:24:38,585 --> 01:24:41,555 THE RACIAL AND ETHNIC GROUPS. 1912 01:24:41,555 --> 01:24:43,423 THERE'S ALSO A WRITE-IN OPTION 1913 01:24:43,423 --> 01:24:45,692 FOR ALL RACIAL AND ETHNIC GROUPS 1914 01:24:45,692 --> 01:24:47,360 SO WE ARE AS AGENCIES SUPPOSED 1915 01:24:47,360 --> 01:24:50,664 TO ALLOW WRITE-IN. 1916 01:24:50,664 --> 01:24:54,801 OMB GAVE US 18 MONTHS TO CREATE 1917 01:24:54,801 --> 01:24:56,636 AN ACTION PLAN AND FIVE YEARS TO 1918 01:24:56,636 --> 01:24:57,637 IMPLEMENT CHANGES. 1919 01:24:57,637 --> 01:24:59,906 WHAT THAT LOOKS LIKE GOING 1920 01:24:59,906 --> 01:25:02,108 FORWARD I CAN'T TELL YET BUT 1921 01:25:02,108 --> 01:25:03,476 WE'LL WORK ON THAT IN THE NEXT 1922 01:25:03,476 --> 01:25:05,345 SEVERAL YEARS AND DO RECOGNIZE 1923 01:25:05,345 --> 01:25:09,749 WITH ALL THESE GROUPS REALLY 1924 01:25:09,749 --> 01:25:11,885 THERE'S A LOT OF HETEROGENEITY 1925 01:25:11,885 --> 01:25:13,854 WITHIN THE GROUPS. 1926 01:25:13,854 --> 01:25:16,423 >> ANY OTHER COMMENTS OR 1927 01:25:16,423 --> 01:25:18,992 QUESTIONS FROM THE MEMBERS? 1928 01:25:18,992 --> 01:25:29,469 WE HAVE ONE SHORT QUESTION. 1929 01:25:34,541 --> 01:25:37,177 GIVEN MATERNAL HEALTH WE WERE 1930 01:25:37,177 --> 01:25:39,913 WONDERING HOW PREGNANT WOMEN 1931 01:25:39,913 --> 01:25:42,182 WERE INCLUDED AND THE 1932 01:25:42,182 --> 01:25:43,617 IMPLEMENTATION FOR PRGLAC 1933 01:25:43,617 --> 01:25:45,285 SUGGESTING PREGNANT WOMEN BE 1934 01:25:45,285 --> 01:25:45,986 INCLUDED. 1935 01:25:45,986 --> 01:25:47,687 I WONDERED HOW THAT WAS BEING 1936 01:25:47,687 --> 01:25:48,555 CONSIDERED. 1937 01:25:48,555 --> 01:25:50,457 >> ABSOLUTELY. 1938 01:25:50,457 --> 01:25:51,858 THIS GETS BACK TO THE 1939 01:25:51,858 --> 01:25:52,826 HETEROGENEITY WITHIN GROUPS. 1940 01:25:52,826 --> 01:25:54,527 WHEN YOU LOOK AT THE NUMBERS YOU 1941 01:25:54,527 --> 01:25:56,763 SEE WOMEN ARE INCLUDED AT HIGHER 1942 01:25:56,763 --> 01:25:58,832 RATES THAN MEN IN MOST OF OUR 1943 01:25:58,832 --> 01:25:59,833 RESEARCH BUT THERE'S CERTAIN 1944 01:25:59,833 --> 01:26:02,068 GROUPS WHERE IT'S MOST 1945 01:26:02,068 --> 01:26:04,905 CHALLENGING AND PREGNANT AND 1946 01:26:04,905 --> 01:26:05,639 LACTATING INDIVIDUALS ARE ONE OF 1947 01:26:05,639 --> 01:26:06,706 THOSE GROUPS. 1948 01:26:06,706 --> 01:26:15,148 WE ADDRESSED THAT IN INCLUSION 1949 01:26:15,148 --> 01:26:16,583 POLICY AND HOWEVER, IT IS 1950 01:26:16,583 --> 01:26:17,217 ADDRESSED THROUGH REASONS FOR 1951 01:26:17,217 --> 01:26:20,153 EXCLUSION AND ALSO IN BUILDING 1952 01:26:20,153 --> 01:26:21,821 RECRUITMENT AND OUTREACH PLAN. 1953 01:26:21,821 --> 01:26:24,591 THE INCLUSION POLICIES BEGAN IN 1954 01:26:24,591 --> 01:26:26,693 PART BECAUSE OF CONCERNS THAT 1955 01:26:26,693 --> 01:26:29,195 INDIVIDUALS WITH CHILD-BEARING 1956 01:26:29,195 --> 01:26:29,829 POTENTIAL WERE BEING EXCLUDE 1957 01:26:29,829 --> 01:26:32,232 FROM STUDIES AND ONE REASON THAT 1958 01:26:32,232 --> 01:26:36,336 COST IS NOT AN ACCEPTABLE REASON 1959 01:26:36,336 --> 01:26:39,039 FOR EXCLUDING INDIVIDUALS FROM A 1960 01:26:39,039 --> 01:26:40,173 STUDY BECAUSE PEOPLE DIDN'T WANT 1961 01:26:40,173 --> 01:26:44,711 TO PAY FOR PREGNANCY TESTS, 1962 01:26:44,711 --> 01:26:45,145 RIGHT. 1963 01:26:45,145 --> 01:26:47,047 WE ADDRESS THAT IN APPROPRIATE 1964 01:26:47,047 --> 01:26:47,614 INCLUSION AND APPROPRIATE 1965 01:26:47,614 --> 01:26:49,849 REASONS FOR EXCLUSION AND MAKING 1966 01:26:49,849 --> 01:26:51,584 SURE THAT OUTREACH PLANS INCLUDE 1967 01:26:51,584 --> 01:26:55,422 ALL GROUPS AND HAVE REASONS FOR 1968 01:26:55,422 --> 01:26:57,290 EXCLUDING ANY AND IF ORWH HAS 1969 01:26:57,290 --> 01:26:59,392 ANYTHING TO ADD I'D BE HAPPY TO 1970 01:26:59,392 --> 01:27:01,795 DEFER TO THEM. 1971 01:27:01,795 --> 01:27:04,597 >> A MANNER OF CLARIFICATION DO 1972 01:27:04,597 --> 01:27:05,632 YOU EXPRESSLY REQUIRE SOMETHING 1973 01:27:05,632 --> 01:27:07,767 RELATED TO PREGNANCY OR NOT? 1974 01:27:07,767 --> 01:27:11,471 >> I THINK IN TERMS OF EXPRESS 1975 01:27:11,471 --> 01:27:12,339 REQUIREMENTS IT WOULD BE REASON 1976 01:27:12,339 --> 01:27:13,039 FOR EXCLUSION. 1977 01:27:13,039 --> 01:27:15,041 IF PREGNANT OR LACTATING 1978 01:27:15,041 --> 01:27:17,444 INDIVIDUALS WERE INCLUDED FROM A 1979 01:27:17,444 --> 01:27:18,878 STUDY WE'D EXPECT JUSTIFICATION 1980 01:27:18,878 --> 01:27:19,946 FOR THAT THROUGH THE INCLUSION 1981 01:27:19,946 --> 01:27:20,180 POLICY. 1982 01:27:20,180 --> 01:27:23,984 >> THANK YOU. 1983 01:27:23,984 --> 01:27:24,384 >> YOU'RE WELCOME. 1984 01:27:24,384 --> 01:27:25,285 >> THANK YOU SO MUCH FOR MAKING 1985 01:27:25,285 --> 01:27:28,688 TIME FOR US THIS MORNING. 1986 01:27:28,688 --> 01:27:33,360 YOU GAVE US A COUPLE MINUTES. 1987 01:27:33,360 --> 01:27:36,930 WE CAN TAKE A QUICK BREATHER AND 1988 01:27:36,930 --> 01:27:39,899 GET STARTED BACK AT 11:00. >> THANK YOU. 1989 01:27:39,899 --> 01:27:50,143 1990 01:27:42,889 --> 01:27:46,092 >> IF I CAN ASK YOU TO GO TO AS 1991 01:27:46,092 --> 01:27:48,694 WE MOVE FORWARD IF I CAN ASK 1992 01:27:48,694 --> 01:27:52,932 PEOPLE TO SILENCE THEIR PHONES 1993 01:27:52,932 --> 01:27:56,169 AND THEIR TYPING ON THEIR 1994 01:27:56,169 --> 01:27:56,803 COMPUTERS. 1995 01:27:56,803 --> 01:27:58,504 IT SEEMS TO BE WE'RE HEARING A 1996 01:27:58,504 --> 01:27:59,906 LOT OF THE EXTRA BACKGROUND 1997 01:27:59,906 --> 01:28:02,575 CHATTER. 1998 01:28:02,575 --> 01:28:02,975 OAK. 1999 01:28:02,975 --> 01:28:06,746 I THINK WHAT WE'RE GOING TO DO 2000 01:28:06,746 --> 01:28:10,917 IS WE'RE JUST GOING TO GO TO THE 2001 01:28:10,917 --> 01:28:12,452 OPEN DISCUSSION UNTIL 2002 01:28:12,452 --> 01:28:15,121 DR. SCHWETZ GETS HERE AND THEN 2003 01:28:15,121 --> 01:28:20,760 WE WILL INTERRUPT THAT. 2004 01:28:20,760 --> 01:28:27,900 SO WHY DON'T WE OPEN UP THE 2005 01:28:27,900 --> 01:28:38,110 DISCUSSION. 2006 01:28:39,212 --> 01:28:42,248 ANY COMMENTS FROM THE DIRECTOR'S 2007 01:28:42,248 --> 01:28:43,416 REPORT OR ANYTHING YOU WANT IT 2008 01:28:43,416 --> 01:28:44,917 HEAR ABOUT OR FEEDBACK YOU HAVE 2009 01:28:44,917 --> 01:28:48,654 FOR US ON ANY PROGRAMS. 2010 01:28:48,654 --> 01:28:49,622 DR. JONES. 2011 01:28:49,622 --> 01:28:55,328 >> I WANT TO ECHO HOW INCREDIBLY 2012 01:28:55,328 --> 01:28:57,029 IMPRESSIVE YOUR REPORT IS IN 2013 01:28:57,029 --> 01:29:00,566 DEPTH AND BREADTH. 2014 01:29:00,566 --> 01:29:03,169 I FEEL LIKE WHEN YOU ASK FOR 2015 01:29:03,169 --> 01:29:04,437 QUESTIONS EVERYTHING HAS BEEN 2016 01:29:04,437 --> 01:29:06,572 COVERED AND THERE'S A BIG 2017 01:29:06,572 --> 01:29:09,008 CONVERSATION WITH ALL THE RATES 2018 01:29:09,008 --> 01:29:10,576 OF CONGENITAL SYPHILIS AND 2019 01:29:10,576 --> 01:29:12,812 DURING PREGNANCY AND I WANTED TO 2020 01:29:12,812 --> 01:29:14,914 RAISE THAT AS A VERY IMPORTANT 2021 01:29:14,914 --> 01:29:16,249 TOPIC AND IF THERE'S ANYTHING 2022 01:29:16,249 --> 01:29:19,218 YOU WANTED TO SAY ABOUT THAT, 2023 01:29:19,218 --> 01:29:19,652 THANKS. 2024 01:29:19,652 --> 01:29:22,755 >> EXCELLENT TOPIC. 2025 01:29:22,755 --> 01:29:24,557 VERY IMPORTANT PUBLIC ISSUE 2026 01:29:24,557 --> 01:29:26,926 INFECTION RATES OF INDIVIDUALS 2027 01:29:26,926 --> 01:29:29,028 OF ALL AGES. 2028 01:29:29,028 --> 01:29:31,731 WE ARE IN COMMUNICATION WITH THE 2029 01:29:31,731 --> 01:29:33,032 NATIONAL INSTITUTE OF ALLERGY 2030 01:29:33,032 --> 01:29:38,304 AND INFECTIOUS DISEASES ABOUT 2031 01:29:38,304 --> 01:29:41,173 EFFORTS TO UNDERTAKE AND WE'RE 2032 01:29:41,173 --> 01:29:45,678 SITTING ON HHS WIDE SXHT -- 2033 01:29:45,678 --> 01:29:47,380 COMMITTEES IN THAT SPACE TO LOOK 2034 01:29:47,380 --> 01:29:50,516 AT WHERE THE RESEARCH QUESTION 2035 01:29:50,516 --> 01:29:54,887 MAY BE WORKING IN COLLABORATIONS 2036 01:29:54,887 --> 01:29:58,190 WITH PUBLIC CARE AS A PRIMARY 2037 01:29:58,190 --> 01:29:59,625 ISSUE AND WE NEED TO TAKE TIME 2038 01:29:59,625 --> 01:30:02,628 TO BE ABLE TO DESIGN RESEARCH 2039 01:30:02,628 --> 01:30:04,196 APPROACHES THAT WILL ASCERTAIN 2040 01:30:04,196 --> 01:30:05,898 THIS INFORMATION TO ANALYZE THIS 2041 01:30:05,898 --> 01:30:06,866 DATA. 2042 01:30:06,866 --> 01:30:07,199 ABSOLUTELY. 2043 01:30:07,199 --> 01:30:09,302 IT'S ON OUR RADAR. 2044 01:30:09,302 --> 01:30:11,370 DR. ROSS HAS BEEN FANTASTIC AND 2045 01:30:11,370 --> 01:30:15,107 MY EARLY CONVERSATIONS WITH HER 2046 01:30:15,107 --> 01:30:16,375 AND WE ARE PLANNING A LITTLE 2047 01:30:16,375 --> 01:30:17,209 INTERNAL BRAIN STORMING SESSION 2048 01:30:17,209 --> 01:30:17,944 NEXT. 2049 01:30:17,944 --> 01:30:19,812 I HOPE AT THE NEXT MEETING I'LL 2050 01:30:19,812 --> 01:30:21,981 BE ABLE TO GIVE YOU MORE 2051 01:30:21,981 --> 01:30:23,482 PROGRESS ON UPDATES. 2052 01:30:23,482 --> 01:30:25,484 AND DR. SCHWETZ HAS ARRIVED. 2053 01:30:25,484 --> 01:30:27,653 HER PREVIOUS MEETING WITH THE 2054 01:30:27,653 --> 01:30:29,922 NIH DIRECTOR WENT OVER SO -- 2055 01:30:29,922 --> 01:30:32,458 >> APOLOGIES I WAS A COUPLE 2056 01:30:32,458 --> 01:30:32,892 MINUTES LATE. 2057 01:30:32,892 --> 01:30:43,302 I WAS TEXTING FURIOUSLY. 2058 01:30:46,205 --> 01:30:48,407 AND IN HER CAPACITY SHE DIRECTS 2059 01:30:48,407 --> 01:30:51,911 HER DIVISION OF PLANNING AND 2060 01:30:51,911 --> 01:30:57,850 STRATEGIC INITIATIVES KNOWN AS 2061 01:30:57,850 --> 01:30:59,452 DPCPSI IN THE OFFICE OF THE 2062 01:30:59,452 --> 01:30:59,919 DIRECTOR. 2063 01:30:59,919 --> 01:31:06,559 >> AGAIN, APOLOGIES FOR MY 2064 01:31:06,559 --> 01:31:06,826 TARDINESS. 2065 01:31:06,826 --> 01:31:08,561 GOOD MORNING EVERYONE AND THANK 2066 01:31:08,561 --> 01:31:10,596 YOU AGAIN FOR LETTING ME SAY A 2067 01:31:10,596 --> 01:31:13,833 FEW WORDS AT THIS MEETING TODAY. 2068 01:31:13,833 --> 01:31:23,275 THE 60th MEETING AS IT WERE. 2069 01:31:23,275 --> 01:31:33,819 I AM REALLY EXCITED TO BE HERE. 2070 01:31:44,997 --> 01:31:49,335 AND DR. CLAYTON AND HER TEAM AND 2071 01:31:49,335 --> 01:31:51,904 DR. OTA WANG. 2072 01:31:51,904 --> 01:31:56,542 AND JUST BEFORE I SHARE A FEW 2073 01:31:56,542 --> 01:32:01,514 WORDS ABOUT DPCPSI AND ORWH AND 2074 01:32:01,514 --> 01:32:05,217 YOU SAID WORDS ABOUT MYSELF SO 2075 01:32:05,217 --> 01:32:07,753 MAYBE I WON'T TALK ABOUT MYSELF. 2076 01:32:07,753 --> 01:32:08,587 >> YOU SHOULD. 2077 01:32:08,587 --> 01:32:10,790 >> THAT'S PROBABLY THE LEAST 2078 01:32:10,790 --> 01:32:16,996 INTERESTING PART BUT I WILL TELL 2079 01:32:16,996 --> 01:32:22,401 YOU I'M A BIO PHYSICIST BY 2080 01:32:22,401 --> 01:32:24,503 TRAINING AND I'VE BEEN AROUND 2081 01:32:24,503 --> 01:32:25,471 QUITE A BIT AND HELD POSITIONS 2082 01:32:25,471 --> 01:32:27,073 IN THE OFFICE OF THE AT THREE 2083 01:32:27,073 --> 01:32:30,910 DIFFERENT INSTITUTES. 2084 01:32:30,910 --> 01:32:35,915 I LIKE TO SAY I HIT THE 2085 01:32:35,915 --> 01:32:37,083 INSTITUTE TRIFECTA AND PART OF 2086 01:32:37,083 --> 01:32:39,885 INSTITUTE OF NURSING AND THE 2087 01:32:39,885 --> 01:32:43,589 SMALLEST AND MIGHTIEST IN SOME 2088 01:32:43,589 --> 01:32:50,529 WAYS AND MID SIZED AND LARGE 2089 01:32:50,529 --> 01:32:53,365 INSTITUTE I SERVED AS THE ACTING 2090 01:32:53,365 --> 01:32:55,167 PRINCIPAL DEPUTY DIRECTOR OF NIH 2091 01:32:55,167 --> 01:32:56,569 BEFORE SHIFTING TO MY CURRENT 2092 01:32:56,569 --> 01:32:59,905 POSITION BACK IN NOVEMBER WITH 2093 01:32:59,905 --> 01:33:03,909 THE CONFIRMATION OF OUR CURRENT 2094 01:33:03,909 --> 01:33:14,153 NIH DIRECTOR. 2095 01:33:21,594 --> 01:33:29,268 WITHIN DPCPSI WE COLLABORATIVELY 2096 01:33:29,268 --> 01:33:31,904 ADVANCE RESEARCH THROUGH 2097 01:33:31,904 --> 01:33:34,273 INNOVATIVE SOLUTIONS AND WE'RE 2098 01:33:34,273 --> 01:33:36,542 THE HOME OF STRATEGIC 2099 01:33:36,542 --> 01:33:38,210 INITIATIVES PLANNING AND PROGRAM 2100 01:33:38,210 --> 01:33:41,747 COORDINATION FOR ACROSS NIH. 2101 01:33:41,747 --> 01:33:43,482 AND REALLY DPCPSI IS POISED TO 2102 01:33:43,482 --> 01:33:44,617 HELP ADDRESS THE NEEDS OF WOMEN 2103 01:33:44,617 --> 01:33:47,186 WHEN IT COMES TO WOMEN'S HEALTH 2104 01:33:47,186 --> 01:33:48,854 AND WOMEN'S HEALTH RESEARCH 2105 01:33:48,854 --> 01:33:51,423 WHICH I'LL TOUCH ON IN A MOMENT 2106 01:33:51,423 --> 01:33:54,260 BECAUSE OF THE FUNCTIONS WE 2107 01:33:54,260 --> 01:33:54,460 HAVE. 2108 01:33:54,460 --> 01:33:59,231 AND IT REALLY PUSHES FORWARD TO 2109 01:33:59,231 --> 01:34:03,769 LEAD THROUGH THE SYNERGISTIC 2110 01:34:03,769 --> 01:34:04,537 COORDINATION OF OFFICES AND 2111 01:34:04,537 --> 01:34:05,971 FOCUSES ON FOUR MAIN APPROACHES 2112 01:34:05,971 --> 01:34:07,573 FOR HELPING TO CATALYZE SCIENCE 2113 01:34:07,573 --> 01:34:10,342 AND THE WORK THAT WE DO ACROSS 2114 01:34:10,342 --> 01:34:11,477 ALL OF NIH. 2115 01:34:11,477 --> 01:34:13,612 THOSE INCLUDE THINGS LIKE 2116 01:34:13,612 --> 01:34:15,314 IDENTIFYING AND CATALYZING 2117 01:34:15,314 --> 01:34:18,617 RESEARCH TO ADDRESS GAPS IN 2118 01:34:18,617 --> 01:34:21,153 OPPORTUNITIES TO HELP FOSTER 2119 01:34:21,153 --> 01:34:21,854 COLLABORATIONS ACROSS THE 2120 01:34:21,854 --> 01:34:22,488 AGENCY. 2121 01:34:22,488 --> 01:34:24,690 TO DEVELOP METHODS AND HELP TO 2122 01:34:24,690 --> 01:34:26,792 ENABLE THE RESEARCH GOALS AND TO 2123 01:34:26,792 --> 01:34:29,261 SERVE AS AN EXPERIMENTAL TEST 2124 01:34:29,261 --> 01:34:31,430 BED FOR INNOVATIVE NIH WIDE 2125 01:34:31,430 --> 01:34:32,131 ACTIVITIES TO IMPROVE THE HEALTH 2126 01:34:32,131 --> 01:34:36,902 OF THE NATION. 2127 01:34:36,902 --> 01:34:41,941 WE HAVE SEVERAL OFFICES WITHIN 2128 01:34:41,941 --> 01:34:43,475 DPCPSI THAT ADVANCE SCIENCE 2129 01:34:43,475 --> 01:34:44,543 INCLUDING ORWH. 2130 01:34:44,543 --> 01:34:46,312 I'M IN THE GOING TO GIVE YOU THE 2131 01:34:46,312 --> 01:34:50,316 HISTORY OF ORWH YOU PROBABLY AND 2132 01:34:50,316 --> 01:34:52,618 EVERYONE ELSE KNOWS ABOUT THIS 2133 01:34:52,618 --> 01:34:57,122 BUT ORWH HAS BEEN AROUND SINCE 2134 01:34:57,122 --> 01:34:59,291 1990 AND IT HAS WORKED 2135 01:34:59,291 --> 01:35:00,292 TIRELESSLY TO IMPROVE AND 2136 01:35:00,292 --> 01:35:03,662 ADVANCE THE HEALTH OF WOMEN AT 2137 01:35:03,662 --> 01:35:04,830 THE CORE OF ITS MISSION. 2138 01:35:04,830 --> 01:35:07,633 MANY OF OUR 27 INSTITUTES AND 2139 01:35:07,633 --> 01:35:09,401 CENTERS OF COURSE SUPPORT 2140 01:35:09,401 --> 01:35:12,104 RESEARCH RELEVANT TO THE HEALTH 2141 01:35:12,104 --> 01:35:17,509 OF WOMEN AND ORWH ACTS AS A 2142 01:35:17,509 --> 01:35:18,711 FULCRUM TO COORDINATE EFFORTS 2143 01:35:18,711 --> 01:35:21,313 ACROSS THE AGENCY HELPING 2144 01:35:21,313 --> 01:35:23,215 CONNECT THE VARIOUS DOTS AND 2145 01:35:23,215 --> 01:35:24,049 ACCELERATE RESEARCH AND 2146 01:35:24,049 --> 01:35:24,917 SOLUTIONS FOR WOMEN'S HEALTH 2147 01:35:24,917 --> 01:35:26,585 THROUGH A VARIETY OF DIFFERENT 2148 01:35:26,585 --> 01:35:29,521 APPROACHES BUT IN PARTICULAR WE 2149 01:35:29,521 --> 01:35:30,189 HAVE A COORDINATING COMMITTEE 2150 01:35:30,189 --> 01:35:33,692 FOR RESEARCH ON WOMEN'S HEATH 2151 01:35:33,692 --> 01:35:36,629 THAT INVOLVES SEVERAL MANY I.C.s 2152 01:35:36,629 --> 01:35:39,899 ACROSS THE AGENCY AND THEY RUN 2153 01:35:39,899 --> 01:35:43,636 ORWH RUNS A VARIETY OF DIFFERENT 2154 01:35:43,636 --> 01:35:47,506 CAREER DEVELOPMENT PROGRAMS AND 2155 01:35:47,506 --> 01:35:56,515 WE HAVE THE BIRCWH PROGRAM AND 2156 01:35:56,515 --> 01:35:59,251 ORWH PLAYED A KEY ROLE IN ACC 2157 01:35:59,251 --> 01:36:06,859 ACCELERATING SEX AS A VARIABLE 2158 01:36:06,859 --> 01:36:09,561 PROBABLY EIGHT YEARS NOW AND 2159 01:36:09,561 --> 01:36:11,096 HELD MANY RESEARCH HAVEN'T 2160 01:36:11,096 --> 01:36:13,299 WORKSHOPS THAT ORWH HELPED 2161 01:36:13,299 --> 01:36:15,901 SUPPORT AND CO-FUND WITH THE 2162 01:36:15,901 --> 01:36:17,770 I.C.s. 2163 01:36:17,770 --> 01:36:20,072 AND IT HAS BEEN MY PRIVILEGE TO 2164 01:36:20,072 --> 01:36:24,476 HELP SUPPORT ORW DEVELOP THE 2165 01:36:24,476 --> 01:36:26,578 VISION FOR THE FUTURE OF WOMEN'S 2166 01:36:26,578 --> 01:36:30,449 HEALTH RESEARCH AND IN THE 2167 01:36:30,449 --> 01:36:34,620 COMING MONTH OR SO ---ISH AND IN 2168 01:36:34,620 --> 01:36:36,388 THE NEAR FUTURE LATER THIS 2169 01:36:36,388 --> 01:36:39,124 SPRING THEY'LL RELEASE THE NEW 2170 01:36:39,124 --> 01:36:39,925 NIH-WIDE STRATEGIC PLAN FOR THE 2171 01:36:39,925 --> 01:36:45,064 HEALTH OF WOMEN. 2172 01:36:45,064 --> 01:36:46,298 NOW, WE'RE DELIGHT THE 2173 01:36:46,298 --> 01:36:47,066 ADMINISTRATION RECOGNIZE THE 2174 01:36:47,066 --> 01:36:49,068 IMPORTANCE OF RESEARCH ON 2175 01:36:49,068 --> 01:36:52,104 WOMEN'S HEALTH AS A PRIORITY IN 2176 01:36:52,104 --> 01:36:54,907 THE U.S. AND I THINK YOU 2177 01:36:54,907 --> 01:36:57,476 MENTIONED IN YOUR REPORT THAT 2178 01:36:57,476 --> 01:36:58,577 PRESIDENT BIDEN'S WHITE HOUSE 2179 01:36:58,577 --> 01:37:01,714 INITIATIVE ON WOMEN'S HEALTH 2180 01:37:01,714 --> 01:37:02,881 RESEARCH AND THAT RECENT 2181 01:37:02,881 --> 01:37:05,384 EXECUTIVE ORDER THEY DEVELOPED 2182 01:37:05,384 --> 01:37:08,988 IN SUPPORT OF THAT YEEL PRESENTS 2183 01:37:08,988 --> 01:37:09,621 SOME EXCITING OPPORTUNITIES TO 2184 01:37:09,621 --> 01:37:10,856 HELP PLAN FUND AND ADVANCE 2185 01:37:10,856 --> 01:37:13,258 WOMEN'S HEALTH RESEARCH AT NIH. 2186 01:37:13,258 --> 01:37:15,361 AND ON A NATIONAL LEVEL TO 2187 01:37:15,361 --> 01:37:16,795 FACILITATE THE WORK ACROSS 2188 01:37:16,795 --> 01:37:18,097 INTERAGENCY AND I WILL SAY THAT 2189 01:37:18,097 --> 01:37:21,600 THEY TOLD US MULTIPLE TIMES THAT 2190 01:37:21,600 --> 01:37:24,003 THE WORK NIH IS DOING IS 2191 01:37:24,003 --> 01:37:26,438 REALLY -- WE'RE A LEADER IN THIS 2192 01:37:26,438 --> 01:37:28,874 SPACE AND THEY WOULD LOVE TO 2193 01:37:28,874 --> 01:37:30,342 HELP FACILITATE BROADER 2194 01:37:30,342 --> 01:37:30,976 COORDINATION ACROSS THE FEDERAL 2195 01:37:30,976 --> 01:37:32,845 GOVERNMENT. 2196 01:37:32,845 --> 01:37:34,780 BUT WE KNOW THERE'S MORE WE CAN 2197 01:37:34,780 --> 01:37:36,248 DO TO ADVANCE RESEARCH ON 2198 01:37:36,248 --> 01:37:39,018 WOMEN'S HEALTH AND TO HELP 2199 01:37:39,018 --> 01:37:40,386 ADDRESS THE GAPS IN KNOWLEDGE 2200 01:37:40,386 --> 01:37:42,121 THAT EXIST BECAUSE WE KNOW 2201 01:37:42,121 --> 01:37:43,389 HEALTHY WOMEN CONTRIBUTE TO 2202 01:37:43,389 --> 01:37:45,057 HEALTHY FAMILIES AND HEALTHY 2203 01:37:45,057 --> 01:37:46,692 COMMUNITIES, HEALTHY CITIES, 2204 01:37:46,692 --> 01:37:48,694 HEALTHY ECONOMIES AND SO MUCH 2205 01:37:48,694 --> 01:37:51,497 MORE BASICALLY AND BENEFITS 2206 01:37:51,497 --> 01:37:51,764 EVERYONE. 2207 01:37:51,764 --> 01:37:54,066 NIH IS REALLY EXCITED AND 2208 01:37:54,066 --> 01:37:55,901 PREPARED TO HELP LEVERAGE THE 2209 01:37:55,901 --> 01:37:58,904 RECENT EXECUTIVE ORDER TO 2210 01:37:58,904 --> 01:38:04,009 ACCELERATE RESEARCH TO HELP 2211 01:38:04,009 --> 01:38:07,012 PREVENT, DIAGNOSE AND TREAT 2212 01:38:07,012 --> 01:38:10,249 CONDITIONS THAT AFFECT WOMEN 2213 01:38:10,249 --> 01:38:12,651 UNIQUELY, DISPROPORTIONATELY AND 2214 01:38:12,651 --> 01:38:13,252 DIFFERENTLY. 2215 01:38:13,252 --> 01:38:14,820 JANINE I THINK YOU MENTION THE 2216 01:38:14,820 --> 01:38:18,190 OFFICE OF DISEASE PREVENTION 2217 01:38:18,190 --> 01:38:20,259 RECENTLY ANNOUNCED IT KICK OFF 2218 01:38:20,259 --> 01:38:23,896 AN INTERAGENCY PORTFOLIO REVIEW 2219 01:38:23,896 --> 01:38:24,963 EFFORT AND HOST A WORKSHOP NEXT 2220 01:38:24,963 --> 01:38:27,399 YEAR ON THE MANAGEMENT OF 2221 01:38:27,399 --> 01:38:29,101 MENOPAUSAL SYMPTOMS AS A FIRST 2222 01:38:29,101 --> 01:38:30,335 STEP IN THE PROCESS FOR A 2223 01:38:30,335 --> 01:38:32,438 PATHWAYS TO PREVENTION PROGRAM. 2224 01:38:32,438 --> 01:38:35,541 I KNOW THAT ON THE AGENDA LATER 2225 01:38:35,541 --> 01:38:36,875 TODAY THERE'S THE MID LIFE 2226 01:38:36,875 --> 01:38:39,878 HEALTH OF WOMEN IN MENOPAUSE 2227 01:38:39,878 --> 01:38:41,146 DISCUSSION THAT WILL PROVIDE I'M 2228 01:38:41,146 --> 01:38:42,881 SURE AN EXCELLENT OVERVIEW OF 2229 01:38:42,881 --> 01:38:44,650 THE TOPIC. 2230 01:38:44,650 --> 01:38:47,219 AND THEN WE ALSO JUST ONE LAST 2231 01:38:47,219 --> 01:38:48,420 THING TO MENTION THAT I'LL 2232 01:38:48,420 --> 01:38:51,123 HIGHLIGHT FOR YOU ALL WE 2233 01:38:51,123 --> 01:38:53,792 RECENTLY PUBLISHED A NOTICE OF 2234 01:38:53,792 --> 01:38:55,060 SPECIAL INTEREST IN RECEIVING 2235 01:38:55,060 --> 01:38:56,829 RESEARCH APPLICATIONS THAT ARE 2236 01:38:56,829 --> 01:38:59,031 FOCUSSED ON DISEASES AND HEALTH 2237 01:38:59,031 --> 01:39:02,167 CONDITIONS THAT PREDOMINANTLY 2238 01:39:02,167 --> 01:39:03,969 AFFECT WOMEN PRESENT OR PROGRESS 2239 01:39:03,969 --> 01:39:04,670 DIFFERENTLY IN WOMEN OR ARE 2240 01:39:04,670 --> 01:39:07,139 FEMALE SPECIFIC. 2241 01:39:07,139 --> 01:39:11,110 SO THAT WAS JUST SORT OF A LOT 2242 01:39:11,110 --> 01:39:12,411 OF INFORMATION THAT I JUST 2243 01:39:12,411 --> 01:39:15,547 DUMPED AT YOU BUT THE SHORT 2244 01:39:15,547 --> 01:39:21,220 VERSION IS THAT WE ACROSS ALL OF 2245 01:39:21,220 --> 01:39:23,655 NIH AND ACROSS DPCPSI ARE 2246 01:39:23,655 --> 01:39:25,657 EXCITED AT THIS I THINK 2247 01:39:25,657 --> 01:39:27,659 IMPORTANT POINT WE'RE AT BOTH 2248 01:39:27,659 --> 01:39:30,529 NATIONALLY AND FEDERALLY AND 2249 01:39:30,529 --> 01:39:31,630 SCIENTIFICALLY AS WELL TO HELP 2250 01:39:31,630 --> 01:39:34,666 COORDINATE AND ACCELERATE ON 2251 01:39:34,666 --> 01:39:37,436 WOMEN'S HEALTH AND HONORED TO BE 2252 01:39:37,436 --> 01:39:38,437 A PART OF TODAY'S MEETING AND 2253 01:39:38,437 --> 01:39:40,572 LOOK FORWARD TO WORKING WITH ALL 2254 01:39:40,572 --> 01:39:44,042 OF YOU AND VARIOUS WAYS TO 2255 01:39:44,042 --> 01:39:45,577 ADDRESS THE UNIQUE HEALTH NEEDS 2256 01:39:45,577 --> 01:39:46,712 AND CHALLENGES FACED BY WOMEN 2257 01:39:46,712 --> 01:39:47,713 ACROSS THE LIFE SPAN. 2258 01:39:47,713 --> 01:39:49,648 WITH THAT I'LL TURN IT BACK TO 2259 01:39:49,648 --> 01:39:50,115 JANINE. 2260 01:39:50,115 --> 01:39:58,190 >> THANK YOU, SO MUCH, TARA. 2261 01:39:58,190 --> 01:40:00,359 DR. OTA WANG WOULD YOU LIKE TO 2262 01:40:00,359 --> 01:40:01,760 INTRODUCE THE NEXT SPEAKER. 2263 01:40:01,760 --> 01:40:06,765 WE'RE ON TIME. 2264 01:40:06,765 --> 01:40:08,500 >> WE'LL DEFER THE LAST 2265 01:40:08,500 --> 01:40:09,735 QUESTIONS AND COMMENTS TO OUR 2266 01:40:09,735 --> 01:40:10,702 OPEN DISCUSSION PERIOD SO YOU 2267 01:40:10,702 --> 01:40:12,404 HAVEN'T LOST THAT TIME. 2268 01:40:12,404 --> 01:40:15,874 I'D LIKE TO INTRODUCE OUR NEXT 2269 01:40:15,874 --> 01:40:16,108 SPEAKER. 2270 01:40:16,108 --> 01:40:18,310 DR. ELIZABETH BARR AS YOU HEARD 2271 01:40:18,310 --> 01:40:20,345 THIS MORNING IS THE NEW 2272 01:40:20,345 --> 01:40:22,948 ASSOCIATE DIRECTOR OF THE 2273 01:40:22,948 --> 01:40:23,782 INTERDISCIPLINARY RESEARCH. 2274 01:40:23,782 --> 01:40:25,951 SHE'S FORMERLY A PROGRAM OFFICER 2275 01:40:25,951 --> 01:40:28,220 IN OUR OFFICE WHERE SHE 2276 01:40:28,220 --> 01:40:31,790 COORDINATED EFFORTS TO ADVANCE 2277 01:40:31,790 --> 01:40:39,031 INTERSECTIONAL GENDER AS A 2278 01:40:39,031 --> 01:40:40,365 SOCIAL VARIABLE AND LET EFFORTS 2279 01:40:40,365 --> 01:40:42,434 TO ADVANCE HIV RESEARCH FOR 2280 01:40:42,434 --> 01:40:42,634 WOMEN. 2281 01:40:42,634 --> 01:40:44,436 HER BACKGROUND IN IS GENDER AND 2282 01:40:44,436 --> 01:40:50,576 WOMEN'S STUDIES, COMMUNITY-LED 2283 01:40:50,576 --> 01:40:52,844 HIV RESEARCH AND PREPRODUCTIVE 2284 01:40:52,844 --> 01:41:01,220 JUSTICE AND COMPLETED HER WORK 2285 01:41:01,220 --> 01:41:03,822 IN WOMEN AND GERDER STUDIES. 2286 01:41:03,822 --> 01:41:06,058 PRIOR TO JOINING ORWH SHE SERVED 2287 01:41:06,058 --> 01:41:07,926 ON THE FACULTY AT TOWSON 2288 01:41:07,926 --> 01:41:10,028 UNIVERSITY AND UNIVERSITY OF 2289 01:41:10,028 --> 01:41:11,196 MARYLAND BALTIMORE COUNTY AND 2290 01:41:11,196 --> 01:41:12,864 LED INTERDISCIPLINARY 2291 01:41:12,864 --> 01:41:13,865 CROSS-SECTOR PROJECTS TO 2292 01:41:13,865 --> 01:41:15,901 INCREASE WOMEN'S ENGAGEMENT IN 2293 01:41:15,901 --> 01:41:18,437 CLINICAL RESEARCH. 2294 01:41:18,437 --> 01:41:19,304 WELCOME, DR. BARR. 2295 01:41:19,304 --> 01:41:20,305 >> THANK YOU SO MUCH. 2296 01:41:20,305 --> 01:41:23,275 I'M DELIGHTED TO BE HERE TODAY 2297 01:41:23,275 --> 01:41:26,378 TO TALK A BIT ABOUT ENHANCING 2298 01:41:26,378 --> 01:41:31,383 COMMUNITY ENGAGEMENT AT ORWH. 2299 01:41:31,383 --> 01:41:32,918 COMMUNITY ENGAGEMENT CAN BE 2300 01:41:32,918 --> 01:41:34,820 DEFINED AS THE PROCESS OF 2301 01:41:34,820 --> 01:41:36,755 WORKING COLLABORATIVELY WITH AND 2302 01:41:36,755 --> 01:41:41,593 THROUGH GROUPS OF PEOPLE 2303 01:41:41,593 --> 01:41:42,127 AFFILIATED BY GEOGRAPHIC 2304 01:41:42,127 --> 01:41:43,862 PROXIMITY TO ADDRESS ISSUES 2305 01:41:43,862 --> 01:41:44,463 ADDRESSING THE WELL BEING OF 2306 01:41:44,463 --> 01:41:47,399 THOSE PEOPLE. 2307 01:41:47,399 --> 01:41:49,701 AND COMMUNITY ENGAGEMENT IS 2308 01:41:49,701 --> 01:41:53,071 REALLY KEY TO IMPROVING HUMAN 2309 01:41:53,071 --> 01:41:53,805 HEALTH. 2310 01:41:53,805 --> 01:41:55,007 REGULAR, MEANINGFUL COMMUNITY 2311 01:41:55,007 --> 01:41:59,444 ENGAGEMENT SAY IS A WIDELY 2312 01:41:59,444 --> 01:42:01,213 ACCEPTED BEST PRACTICE IN HEALTH 2313 01:42:01,213 --> 01:42:01,480 RESEARCH. 2314 01:42:01,480 --> 01:42:05,183 IN 2010 THE DIRECTOR'S COUNCIL 2315 01:42:05,183 --> 01:42:05,917 PUBLIC REPRESENTATIVES DEVELOPED 2316 01:42:05,917 --> 01:42:07,786 A COMMUNITY ENGAGEMENT FRAMEWORK 2317 01:42:07,786 --> 01:42:09,588 THAT ARTICULATED VALUES AND 2318 01:42:09,588 --> 01:42:10,756 STRATEGY FOR COMMUNITY 2319 01:42:10,756 --> 01:42:11,189 ENGAGEMENT. 2320 01:42:11,189 --> 01:42:13,091 SOME OF THE BENEFITS OF 2321 01:42:13,091 --> 01:42:15,894 COMMUNITY ENGAGEMENT DOCUMENTS 2322 01:42:15,894 --> 01:42:17,329 ARE IN THE LITERATURE INCLUDE 2323 01:42:17,329 --> 01:42:19,398 INCREASED AND EXPANDED 2324 01:42:19,398 --> 01:42:21,867 RECRUITMENT AND RETENTION, 2325 01:42:21,867 --> 01:42:23,669 IMPROVED RESEARCH QUALITY, 2326 01:42:23,669 --> 01:42:27,005 ENHANCED RESEARCH EFFECTIVENESS, 2327 01:42:27,005 --> 01:42:29,775 INCREASED TRUST IN RESEARCH, 2328 01:42:29,775 --> 01:42:30,409 DEMONSTRATED RESPECT OR 2329 01:42:30,409 --> 01:42:31,910 COMMUNITY AND INCREASED UPTAKE 2330 01:42:31,910 --> 01:42:35,213 OF RESEARCH FINDINGS. 2331 01:42:35,213 --> 01:42:38,483 ACROSS THE NIH, MULTIPLE 2332 01:42:38,483 --> 01:42:39,885 COMMUNITY ENGAGEMENT PROCESSES 2333 01:42:39,885 --> 01:42:41,486 ARE IN PLACE TO SUPPORT 2334 01:42:41,486 --> 01:42:43,789 COMMUNITY ENGAGEMENT. 2335 01:42:43,789 --> 01:42:45,724 A FEW REPRESENTATIVE EXAMPLES 2336 01:42:45,724 --> 01:42:50,262 ARE SHOWN HERE AND INCLUDE 2337 01:42:50,262 --> 01:42:52,297 EFFORTS IN INTRAMURAL PROGRAMS, 2338 01:42:52,297 --> 01:42:53,465 EXTRAMURAL PROGRAMS, COMMUNITY 2339 01:42:53,465 --> 01:42:54,066 ADVISORY BOARDS AND COMMUNITY 2340 01:42:54,066 --> 01:43:04,209 FORUMS. 2341 01:43:06,978 --> 01:43:08,880 ORWH HAS PERSPECTIVES THROUGH AD 2342 01:43:08,880 --> 01:43:09,481 HOC EFFORTS. 2343 01:43:09,481 --> 01:43:11,616 FOR EXAMPLE, ORWH HOSTED A 2344 01:43:11,616 --> 01:43:14,619 NUMBER OF LISTENING SESSIONS 2345 01:43:14,619 --> 01:43:17,055 INCLUDING AT THE MOST RECENT 2346 01:43:17,055 --> 01:43:20,859 U.S. CONFERENCE ON HIV AND AIDS. 2347 01:43:20,859 --> 01:43:22,728 ORWH HAD ISSUED REQUEST FOR 2348 01:43:22,728 --> 01:43:25,130 INFORMATION OR RFIs ON SPECIFIC 2349 01:43:25,130 --> 01:43:26,832 TOPICS. 2350 01:43:26,832 --> 01:43:29,534 THESE ENGAGEMENTS ARE INTEGRAL 2351 01:43:29,534 --> 01:43:31,136 TO ORWH PLANNING AND 2352 01:43:31,136 --> 01:43:32,771 PROGRAMMATIC EFFORTS. 2353 01:43:32,771 --> 01:43:34,840 HOWEVER, THE VALUE OF THESE 2354 01:43:34,840 --> 01:43:37,142 ENGAGEMENTS CAN BE CHALLENGING 2355 01:43:37,142 --> 01:43:39,378 TO SUSTAIN WITHOUT A SYSTEMATIC 2356 01:43:39,378 --> 01:43:39,911 APPROACH AND SUPPORTIVE 2357 01:43:39,911 --> 01:43:45,050 INFRASTRUCTURE. 2358 01:43:45,050 --> 01:43:46,718 SO TO MEET THE NEED FOR 2359 01:43:46,718 --> 01:43:47,819 SUSTAINED COMMUNITY PARTNERSHIP 2360 01:43:47,819 --> 01:43:50,422 AND TO ENSURE RESPONSIVENESS TO 2361 01:43:50,422 --> 01:43:53,125 AND INPUT FROM THE WOMEN THAT 2362 01:43:53,125 --> 01:43:57,129 ORWH SERVES, ORWH PROPOSES 2363 01:43:57,129 --> 01:44:01,400 ESTABLISHING A STANDING ACRWH 2364 01:44:01,400 --> 01:44:02,000 ENGAGING SUBCOMMITTEE TO BE 2365 01:44:02,000 --> 01:44:02,567 COMPRISED OF PATIENTS AND 2366 01:44:02,567 --> 01:44:05,103 COMMUNITY MEMBERS. 2367 01:44:05,103 --> 01:44:08,006 THE PURPOSE OF THIS SUBCOMMITTEE 2368 01:44:08,006 --> 01:44:11,076 IS TO ELICIT REGULAR, ONGOING, 2369 01:44:11,076 --> 01:44:12,511 COMMUNITY AND PATIENT-FOCUSSED 2370 01:44:12,511 --> 01:44:14,045 INPUT INTO ORWH PROGRAMS AND 2371 01:44:14,045 --> 01:44:17,182 PRIORITIES. 2372 01:44:17,182 --> 01:44:18,750 THROUGH CONTINUOUS ENGAGEMENT 2373 01:44:18,750 --> 01:44:21,853 AND PARTNERSHIP WITH DIVERSE 2374 01:44:21,853 --> 01:44:23,889 CONSTITUENTS, THE SUBCOMMITTEE 2375 01:44:23,889 --> 01:44:25,857 WILL PROVIDE AN INFRASTRUCTURE 2376 01:44:25,857 --> 01:44:26,825 FOR INFORMATION DISSEMINATION 2377 01:44:26,825 --> 01:44:29,594 AND COLLABORATIONS AND ALSO 2378 01:44:29,594 --> 01:44:32,998 INFORM ORWH PROGRAMMATIC 2379 01:44:32,998 --> 01:44:33,298 ACTIVITIES. 2380 01:44:33,298 --> 01:44:35,567 POTENTIAL DELIVERABLES FROM THE 2381 01:44:35,567 --> 01:44:38,203 SUBCOMMITTEE MAY INCLUDE 2382 01:44:38,203 --> 01:44:38,770 COMMUNITY-FOCUSSED HEALTH 2383 01:44:38,770 --> 01:44:39,805 INFORMATION FOR EXAMPLE, 2384 01:44:39,805 --> 01:44:41,840 WEBINARS OR FACT SHEETS OR 2385 01:44:41,840 --> 01:44:43,208 FREQUENTLY ASKED QUESTIONS ABOUT 2386 01:44:43,208 --> 01:44:44,342 TOPICS OF RELEVANCE TO THE 2387 01:44:44,342 --> 01:44:50,582 HEALTH OF WOMEN. 2388 01:44:50,582 --> 01:44:52,918 IN 2023 A SERIES OF MEETINGS 2389 01:44:52,918 --> 01:44:55,220 OCCURRED WITH EXISTING NIH 2390 01:44:55,220 --> 01:44:55,854 COMMUNITY ENGAGEMENT EFFORTS 2391 01:44:55,854 --> 01:44:58,156 WITH THE GOAL OF UNDERSTANDING 2392 01:44:58,156 --> 01:45:00,692 BEST PRACTICES AND LESSONS 2393 01:45:00,692 --> 01:45:02,561 LEARNED FOR SUSTAINING 2394 01:45:02,561 --> 01:45:03,829 MEANINGFUL COMMUNITY ENGAGEMENT 2395 01:45:03,829 --> 01:45:04,663 AT NIH. 2396 01:45:04,663 --> 01:45:07,532 SOME OF THE EFFORTS THAT WERE 2397 01:45:07,532 --> 01:45:09,234 CONSULTED INCLUDED COMMUNITY 2398 01:45:09,234 --> 01:45:12,537 ADVISORY BOARDS OR CABS, FOR 2399 01:45:12,537 --> 01:45:16,508 EXAMPLE, WITH RAD X UP FOR THE 2400 01:45:16,508 --> 01:45:18,310 NIAID RESEARCH NETWORK AND STUDY 2401 01:45:18,310 --> 01:45:25,217 AGNOSTIC ENGAGEMENT PARTNERSHIPS 2402 01:45:25,217 --> 01:45:28,019 INCLUDING HEAL AND THE NHLBI 2403 01:45:28,019 --> 01:45:30,255 HEART HEALTHY NETWORK AND 2404 01:45:30,255 --> 01:45:32,858 ONGOING AND DISCREET COMMUNITY 2405 01:45:32,858 --> 01:45:34,292 ENGAGEMENT EFFORTS LIKE THE 2406 01:45:34,292 --> 01:45:36,962 HIEHS COMMUNITY FORUM. 2407 01:45:36,962 --> 01:45:39,397 COMMUNITY ENGAGEMENT EFFORTS 2408 01:45:39,397 --> 01:45:41,933 WERE ASKED ABOUT THEIR 2409 01:45:41,933 --> 01:45:44,769 STRUCTURE, SCOPE AND LOGISTICS 2410 01:45:44,769 --> 01:45:46,771 AND SHARE BEST PRACTICES AND 2411 01:45:46,771 --> 01:45:47,606 LESSONS LEARNED. 2412 01:45:47,606 --> 01:45:50,475 TWO KEY LEARNINGS EMERGED. 2413 01:45:50,475 --> 01:45:53,745 FIRST, COMPENSATION FOR 2414 01:45:53,745 --> 01:45:55,914 COMMUNITY MEMBERS' TIME AND 2415 01:45:55,914 --> 01:45:59,918 EXPERTISE IS AN ESSENTIAL 2416 01:45:59,918 --> 01:46:00,385 ELEMENT OF STRUCTURES. 2417 01:46:00,385 --> 01:46:02,120 SECOND, CLARITY OF PURPOSE, 2418 01:46:02,120 --> 01:46:03,922 CLARITY OF SCOPE AND CLARITY OF 2419 01:46:03,922 --> 01:46:05,557 EXPECTATIONS ARE CRITICAL 2420 01:46:05,557 --> 01:46:06,825 ELEMENTS OF SUCCESSFUL COMMUNITY 2421 01:46:06,825 --> 01:46:11,196 ENGAGEMENT STRUCTURES. 2422 01:46:11,196 --> 01:46:12,664 INITIAL DIALOGUE SHOULD 2423 01:46:12,664 --> 01:46:13,965 ASCERTAIN WHAT WILL BE ASKED OF 2424 01:46:13,965 --> 01:46:16,468 COMMUNITY MEMBERS, FOR EXAMPLE, 2425 01:46:16,468 --> 01:46:17,335 HOW MUCH WILL WILL THEY BE ASKED 2426 01:46:17,335 --> 01:46:19,337 TO PARTICIPATE, WHAT TYPE OF 2427 01:46:19,337 --> 01:46:21,039 FEEDBACK WILL THEY BE EXPECTED 2428 01:46:21,039 --> 01:46:22,173 TO GIVE AS WELL AS CLARIFYING 2429 01:46:22,173 --> 01:46:24,643 WHAT SHOULD AND SHOULD NOT BE 2430 01:46:24,643 --> 01:46:26,478 EXPECTED FROM ORWH FOR EXAMPLE 2431 01:46:26,478 --> 01:46:29,948 HOW WE MAY AND MAY NOT BE ABLE 2432 01:46:29,948 --> 01:46:32,083 TO SOLICIT AND IMPLEMENT THEIR 2433 01:46:32,083 --> 01:46:36,621 INPUT. 2434 01:46:36,621 --> 01:46:38,390 A PHASED APPROACH TO BUILDING 2435 01:46:38,390 --> 01:46:43,528 THE SUBCOMMITTEE WOULD ENTAIL 2436 01:46:43,528 --> 01:46:45,397 BRINGING ON MEMBERS FOR 2437 01:46:45,397 --> 01:46:50,068 EIGHT-YEAR TERMS WITH AN 2438 01:46:50,068 --> 01:46:53,171 OPTIONAL FOUR-YEAR AND TAKE THIS 2439 01:46:53,171 --> 01:46:56,575 APPROACH INCLUDES THE CAVEAT NOT 2440 01:46:56,575 --> 01:46:58,610 ALL PERSPECTIVES WILL BE 2441 01:46:58,610 --> 01:47:01,012 REPRESENTED SIMULTANEOUSLY BUT 2442 01:47:01,012 --> 01:47:09,588 THE BENEFITS INCLUDE THOUGHTFUL 2443 01:47:09,588 --> 01:47:13,892 DEVELOPMENT OF THE INITIATIVE 2444 01:47:13,892 --> 01:47:19,831 AND MEET VIRTUALLY AND HYBRID 2445 01:47:19,831 --> 01:47:22,500 FORMAT AND DELIVERABLES COULD BE 2446 01:47:22,500 --> 01:47:25,737 WEBINARS, FREQUENTLY ASKED 2447 01:47:25,737 --> 01:47:26,938 QUESTIONS, SHORT VIDEOS, COMMENT 2448 01:47:26,938 --> 01:47:31,376 OR INFO GRAPHICS INFORMED BY THE 2449 01:47:31,376 --> 01:47:33,712 INPUT OF THE SUBCOMMITTEE. 2450 01:47:33,712 --> 01:47:34,446 POTENTIAL PERSPECTIVES TO BE 2451 01:47:34,446 --> 01:47:37,182 INCLUDED ARE SHOWN ON THE SLIDE 2452 01:47:37,182 --> 01:47:40,685 IN ALPHABETICAL ORDER AND 2453 01:47:40,685 --> 01:47:41,453 GROUPED BY THOSE DISEASE OR 2454 01:47:41,453 --> 01:47:44,289 CONDITION AGNOSTIC AND THOSE 2455 01:47:44,289 --> 01:47:47,792 CONDITION SPECIFIC. 2456 01:47:47,792 --> 01:47:50,929 SO FOR EXAMPLE INCLUDING DIVERSE 2457 01:47:50,929 --> 01:47:53,798 POPULATIONS, OLDER WOMEN, 2458 01:47:53,798 --> 01:47:56,768 INDIVIDUALS WITH EXPERIENCE OF 2459 01:47:56,768 --> 01:47:58,470 SUBSTANCE USE AS WELL AS 2460 01:47:58,470 --> 01:48:03,475 INCLUDING PATIENT PERSPECTIVES 2461 01:48:03,475 --> 01:48:13,084 FOR EXAMPLE, HIV OR NEUROLOGICAL 2462 01:48:13,084 --> 01:48:13,718 DISCOV 2463 01:48:13,718 --> 01:48:14,853 DISCOVERIES AND THOSE I PICKED 2464 01:48:14,853 --> 01:48:16,388 AT RANDOM. 2465 01:48:16,388 --> 01:48:19,391 AND WE WOULD ESTABLISH A 2466 01:48:19,391 --> 01:48:21,960 SUBCOMMITTEE TODAY AT THE 60th 2467 01:48:21,960 --> 01:48:28,800 MEEKT -- MEETING FOLLOWED BY A 2468 01:48:28,800 --> 01:48:30,468 MEMBERSHIP SOLICITATION AND 2469 01:48:30,468 --> 01:48:34,172 PROPOSE REVIEWING THE STATEMENTS 2470 01:48:34,172 --> 01:48:35,607 OF INTERESTS, HAVING 2471 01:48:35,607 --> 01:48:37,108 CONVERSATIONS WITH NOMINEES AND 2472 01:48:37,108 --> 01:48:37,742 INVITING THE FIRST ROUND OF 2473 01:48:37,742 --> 01:48:38,877 MEMBERS AND IF ALL GOES AS 2474 01:48:38,877 --> 01:48:43,415 PLANNED HAVING THE FIRST MEET IN 2475 01:48:43,415 --> 01:48:47,052 CONJUNCTION WITH THE FALL ORWH 2476 01:48:47,052 --> 01:48:47,285 MEETING. 2477 01:48:47,285 --> 01:48:48,653 I'M EAGER TO HEAR YOUR QUESTIONS 2478 01:48:48,653 --> 01:48:53,825 AND IDEAS FOR HOW WE MIGHT 2479 01:48:53,825 --> 01:48:56,261 IMPLEMENT THE SUBCOMMITTEE AND 2480 01:48:56,261 --> 01:48:58,496 WILL NOW ANSWER THEM. 2481 01:48:58,496 --> 01:49:02,067 >> WE'LL NOW OPEN THE FLOOR FOR 2482 01:49:02,067 --> 01:49:10,408 QUESTIONS AND COMMENTS. 2483 01:49:10,408 --> 01:49:13,611 >> I'M INTERESTED IN ARE YOU 2484 01:49:13,611 --> 01:49:15,547 WANTING PEOPLE WOULD HAVE 2485 01:49:15,547 --> 01:49:17,582 EXPERIENCE IN RESEARCH OR 2486 01:49:17,582 --> 01:49:19,617 ADVOCACY OR MORE GENERAL 2487 01:49:19,617 --> 01:49:21,252 POPULATION? 2488 01:49:21,252 --> 01:49:22,687 >> I THINK IDEALLY WE'D HAVE A 2489 01:49:22,687 --> 01:49:26,057 BALANCE BUT THE GOAL IS TO HAVE 2490 01:49:26,057 --> 01:49:29,394 INDIVIDUALS SPEAK FROM THEIR 2491 01:49:29,394 --> 01:49:31,362 EXPERIENCE AS INDIVIDUALS SO NOT 2492 01:49:31,362 --> 01:49:32,497 NECESSARILY FOLKS WHO 2493 01:49:32,497 --> 01:49:33,598 PARTICIPATED IN A RESEARCH STUDY 2494 01:49:33,598 --> 01:49:35,867 BUT INDIVIDUALS WHO MIGHT BE 2495 01:49:35,867 --> 01:49:39,437 ABLE TO SPEAK TO WHAT IT'S LIKE 2496 01:49:39,437 --> 01:49:41,606 TO HAVE A PERSON WITH HIV 2497 01:49:41,606 --> 01:49:43,875 SEEKING CARE IN THE SOUTHERN 2498 01:49:43,875 --> 01:49:47,946 U.S. FOR EXAMPLE. 2499 01:49:47,946 --> 01:49:50,415 >> THANK YOU VERY MUCH FOR THE 2500 01:49:50,415 --> 01:49:50,749 PRESENTATION. 2501 01:49:50,749 --> 01:49:53,084 IT'S VERY EXCITING INITIATIVE. 2502 01:49:53,084 --> 01:49:56,387 DO YOU HAVE ANY THOUGHTS ON HOW 2503 01:49:56,387 --> 01:50:00,225 YOU'RE GOING TO PLACE THE CALL 2504 01:50:00,225 --> 01:50:03,328 FOR NOMINATIONS OR 2505 01:50:03,328 --> 01:50:03,728 SELF-NOMINATIONS? 2506 01:50:03,728 --> 01:50:05,897 HOW ARE YOU GOING DISTRIBUTE 2507 01:50:05,897 --> 01:50:07,332 THAT ACROSS THE COUNTRY IN ORDER 2508 01:50:07,332 --> 01:50:12,604 TO GAIN ABOUT WHAT YOU THINK IS 2509 01:50:12,604 --> 01:50:15,473 A COMFORTABLE REPRESENTATIVE 2510 01:50:15,473 --> 01:50:16,441 SAMPLE THAT LEADS YOU TO THE 2511 01:50:16,441 --> 01:50:17,408 SELECTION OF EIGHT. 2512 01:50:17,408 --> 01:50:19,878 >> THAT'S A WONDERFUL QUESTION, 2513 01:50:19,878 --> 01:50:21,079 DR. SIMON. 2514 01:50:21,079 --> 01:50:23,681 SOME STRATEGIES OTHER NIH 2515 01:50:23,681 --> 01:50:24,983 EFFORTS HAVE USED INCLUDE 2516 01:50:24,983 --> 01:50:27,352 FEDERAL REGISTER NOTICES AND 2517 01:50:27,352 --> 01:50:29,287 ANNOUNCES THE LIST SERVES IN 2518 01:50:29,287 --> 01:50:29,621 SOCIAL MEDIA. 2519 01:50:29,621 --> 01:50:32,957 I THINK POTENTIALLY THERE'S THE 2520 01:50:32,957 --> 01:50:36,060 RISK WE RECEIVE A SOFT 2521 01:50:36,060 --> 01:50:37,762 NOMINATION FOR MEMBERSHIP OF 2522 01:50:37,762 --> 01:50:39,397 EIGHT AND THE RISK WE RECEIVE 2523 01:50:39,397 --> 01:50:41,166 LOWER THAN EXPECTED. 2524 01:50:41,166 --> 01:50:43,034 THE PHASED APPROACH IS A WAY TO 2525 01:50:43,034 --> 01:50:44,335 GUIDE THAT AND KEEP IT 2526 01:50:44,335 --> 01:50:49,974 MANAGEABLE SO THAT IF WE NEED TO 2527 01:50:49,974 --> 01:50:52,744 RETOOL OUR APPROACH WE CAN 2528 01:50:52,744 --> 01:50:57,382 BETTER REPRESENT THE DIVERSE 2529 01:50:57,382 --> 01:50:58,783 EXPERIENCES OF WOMEN ON THE 2530 01:50:58,783 --> 01:50:59,083 COMMITTEE. 2531 01:50:59,083 --> 01:51:01,820 >> AND HAVE YOU HAD SOME 2532 01:51:01,820 --> 01:51:05,056 COMMUNITY INPUT TO THIS 2533 01:51:05,056 --> 01:51:07,325 SELECTION OF EIGHT AS YOUR 2534 01:51:07,325 --> 01:51:10,728 INITIAL AND INTO HOW YOU'LL POSE 2535 01:51:10,728 --> 01:51:10,929 THIS? 2536 01:51:10,929 --> 01:51:14,766 I STRONGLY RECOMMEND THERE'S 2537 01:51:14,766 --> 01:51:20,038 OTHER TOP INITIATIVES THAT HAVE 2538 01:51:20,038 --> 01:51:27,111 COMMUNITY AND SPOKEN TO 2539 01:51:27,111 --> 01:51:29,013 COMMUNITY PARTNERS AND ADVISORY 2540 01:51:29,013 --> 01:51:31,082 BOARDS THEY HAVE TO ACTUALLY 2541 01:51:31,082 --> 01:51:39,057 STRUCTURE THIS PROPOSAL. 2542 01:51:39,057 --> 01:51:43,461 >> UNTIL THERE'S A SUBCOMMITTEE 2543 01:51:43,461 --> 01:51:46,264 WE CANNOT GET ANYONE TO NOMINATE 2544 01:51:46,264 --> 01:51:48,333 THEMSELVES FOR IT BUT IT'S OUR 2545 01:51:48,333 --> 01:51:51,436 HOPE WHILE NOT EVERYONE WILL BE 2546 01:51:51,436 --> 01:51:52,704 COMING WITH EXPERIENCE TO 2547 01:51:52,704 --> 01:51:54,706 PARTICIPATE IN A CAB WE MAY DRAW 2548 01:51:54,706 --> 01:51:56,274 ON FOLKS WHO HAVE FAMILIARITY 2549 01:51:56,274 --> 01:51:57,675 WITH NIH AND RESEARCH AND 2550 01:51:57,675 --> 01:52:00,545 COMMUNITY ENGAGED RESEARCH 2551 01:52:00,545 --> 01:52:00,879 SPECIFICALLY. 2552 01:52:00,879 --> 01:52:03,514 SO I THINK IDEALLY WE'D HAVE 2553 01:52:03,514 --> 01:52:05,783 FOLKS WHO ARE ALREADY SOMEWHAT A 2554 01:52:05,783 --> 01:52:08,786 PART OF THE ECO SYSTEM AS WELL 2555 01:52:08,786 --> 01:52:10,054 AS FOLKS PART OF THE ECO SYSTEM. 2556 01:52:10,054 --> 01:52:13,157 >> SORRY FOR MY LACK OF CLARITY. 2557 01:52:13,157 --> 01:52:15,593 I MEANT HOW DO COMMUNITY INFORM 2558 01:52:15,593 --> 01:52:17,161 THIS PROPOSAL? 2559 01:52:17,161 --> 01:52:17,595 >> OKAY. 2560 01:52:17,595 --> 01:52:19,597 NOW I UNDERSTAND, THANK YOU. 2561 01:52:19,597 --> 01:52:22,000 ONE THING WE HEARD AT LISTENING 2562 01:52:22,000 --> 01:52:24,435 SESSIONS AND REQUEST FOR 2563 01:52:24,435 --> 01:52:26,104 INFORMATION THAT WE PUT OUT IS 2564 01:52:26,104 --> 01:52:28,239 THAT THERE'S A STRONG DESIRE FOR 2565 01:52:28,239 --> 01:52:30,508 ONGOING AND SUSTAINED 2566 01:52:30,508 --> 01:52:35,847 CONVERSATIONS WITH ORWH THAT 2567 01:52:35,847 --> 01:52:37,181 LAPSE BEYOND ONE ENCOUNTER. 2568 01:52:37,181 --> 01:52:42,186 THANK YOU FOR CLARIFYING FOR ME. 2569 01:52:42,186 --> 01:52:47,358 >> DR. AINYAY. 2570 01:52:47,358 --> 01:52:48,660 >> I APPRECIATE THE APPROACH TO 2571 01:52:48,660 --> 01:52:49,994 THE WORK. 2572 01:52:49,994 --> 01:52:52,430 WHAT'S IT LOOK LIKE IN TERM OF 2573 01:52:52,430 --> 01:52:57,735 THEIR ENGAGEMENT TO ORWH OR NIH 2574 01:52:57,735 --> 01:52:57,969 BROADER. 2575 01:52:57,969 --> 01:52:59,671 >> GREAT QUESTION. 2576 01:52:59,671 --> 01:53:03,908 AS A SUBCOMMITTEE OF ACRWH, I 2577 01:53:03,908 --> 01:53:05,576 THINK WE DO HAVE -- SINCE 2578 01:53:05,576 --> 01:53:07,712 NOTHING IS BUILT YET WE HAVE THE 2579 01:53:07,712 --> 01:53:10,915 OPPORTUNITY TO BUILD THINGS AS 2580 01:53:10,915 --> 01:53:13,484 WE WISH BUT FOR EXAMPLE THE 2581 01:53:13,484 --> 01:53:14,652 SUBCOMMITTEES COULD POTENTIALLY 2582 01:53:14,652 --> 01:53:16,621 MEET FOR EXAMPLE THE WEEKEND 2583 01:53:16,621 --> 01:53:20,325 BEFORE THE ACRH MEETING AND 2584 01:53:20,325 --> 01:53:21,459 PERHAPS A LIAISON. 2585 01:53:21,459 --> 01:53:23,928 I THINK WE WANT TO ALLOW SPACE 2586 01:53:23,928 --> 01:53:25,430 FOR THE COMMITTEE MEMBERS TO 2587 01:53:25,430 --> 01:53:30,702 BUILD WHAT IS USEFUL AND 2588 01:53:30,702 --> 01:53:33,071 APPROPRIATE WHILE KEEPING IT 2589 01:53:33,071 --> 01:53:37,809 PART OF ORWH AND PERHAPS A 2590 01:53:37,809 --> 01:53:40,511 LIAISON ROLE BETWEEN THE 2591 01:53:40,511 --> 01:53:42,413 SUBCOMMITTEE AND THE HYBRID 2592 01:53:42,413 --> 01:53:44,182 MEETING IN CONJUNCTION AND 2593 01:53:44,182 --> 01:53:47,485 VIRTUAL MEETINGS IN THE QUARTERS 2594 01:53:47,485 --> 01:53:48,686 WHERE IT DOES NOT MEET IS ONE 2595 01:53:48,686 --> 01:53:52,991 STRATEGY. 2596 01:53:52,991 --> 01:53:56,160 >> THANK YOU FOR A GREAT 2597 01:53:56,160 --> 01:53:56,995 INFORMATION SESSION THERE. 2598 01:53:56,995 --> 01:54:01,399 SO JUST WONDERING IF YOU ALL HAD 2599 01:54:01,399 --> 01:54:02,800 DONE INFORMATION GATHERING FROM 2600 01:54:02,800 --> 01:54:04,936 PCORI BECAUSE THEY HAVE A FOCUS 2601 01:54:04,936 --> 01:54:07,672 ON STAKEHOLDER ENGAGEMENT AND 2602 01:54:07,672 --> 01:54:11,109 THEY HAVE MANUALS ON IT AND SO 2603 01:54:11,109 --> 01:54:15,747 JUST WONDERING IF YOU REACHED 2604 01:54:15,747 --> 01:54:16,247 OUT TO THEM. 2605 01:54:16,247 --> 01:54:17,882 >> WE CONSULTED SOME OF THEIR 2606 01:54:17,882 --> 01:54:19,717 RESOURCES BUT WE HAVEN'T HAD 2607 01:54:19,717 --> 01:54:20,685 CONVERSATIONS WITH THEM BUT IT'S 2608 01:54:20,685 --> 01:54:21,119 A GREAT SUGGESTION. 2609 01:54:21,119 --> 01:54:27,191 THANK YOU. 2610 01:54:27,191 --> 01:54:30,128 >> ANYONE ELSE? 2611 01:54:30,128 --> 01:54:30,862 THANK YOU, DR. BARR. 2612 01:54:30,862 --> 01:54:35,967 >> THANK YOU. 2613 01:54:35,967 --> 01:54:36,834 >> THANK YOU FOR THE GREAT 2614 01:54:36,834 --> 01:54:38,102 DISCUSSION AND FOR THIS 2615 01:54:38,102 --> 01:54:40,338 MORNING'S DISCUSSIONS AND 2616 01:54:40,338 --> 01:54:40,805 PRESENTATIONS. 2617 01:54:40,805 --> 01:54:44,809 SO AT THIS TIME I'M JUST GOING 2618 01:54:44,809 --> 01:54:47,311 TO FORECAST OUR NEXT HOUR OR SO. 2619 01:54:47,311 --> 01:54:49,514 WHAT WE WOULD LIKE TO DO NOW IS 2620 01:54:49,514 --> 01:54:52,483 HAVE OUR MEMBERS JOIN US REALLY 2621 01:54:52,483 --> 01:54:53,951 AT THE SIDE OF THE ROOM TO HAVE 2622 01:54:53,951 --> 01:54:58,256 A GROUP PHOTO AND I WOULD ASK WE 2623 01:54:58,256 --> 01:55:01,125 CAN SEE YOU ON THE SCREEN THAT 2624 01:55:01,125 --> 01:55:03,194 WE'RE GOING TAKE YOU VIRTUALLY 2625 01:55:03,194 --> 01:55:06,664 AND TAKE A SCREEN SHOT OF YOU TO 2626 01:55:06,664 --> 01:55:08,366 SORT OF INCLUDE YOU INTO OUR 2627 01:55:08,366 --> 01:55:09,500 GROUP. 2628 01:55:09,500 --> 01:55:11,002 IF WE COULD FIRST DO OUR GROUP 2629 01:55:11,002 --> 01:55:12,970 PHOTO AND THEN WE'LL HAVE A 2630 01:55:12,970 --> 01:55:13,638 LUNCH BREAK. 2631 01:55:13,638 --> 01:55:17,208 WHAT I ENCOURAGE YOU TO DO IS WE 2632 01:55:17,208 --> 01:55:20,478 HAVE PEOPLE TO HELP GUIDE YOU 2633 01:55:20,478 --> 01:55:22,346 THROUGH THE MAZE OF THE 2634 01:55:22,346 --> 01:55:25,316 CAFETERIA AND BE BACK NO LATER 2635 01:55:25,316 --> 01:55:27,218 THAN 12:40 BECAUSE THE NIH 2636 01:55:27,218 --> 01:55:30,721 DIRECTOR DR. BERTAGNOLLI WILL 2637 01:55:30,721 --> 01:55:33,057 START PROMPTLY AT 12:45. 2638 01:55:33,057 --> 01:55:36,194 THANK YOU FOR A PRODUCTIVE 2639 01:55:36,194 --> 01:55:37,395 MORNING AND LET'S GET OUR PICTURE TAKEN. 2640 01:55:37,395 --> 01:55:38,529 SO WE'RE ADJOURNED FOR LUNCH. THANK YOU. 2641 01:55:38,529 --> 01:55:39,330 2642 01:55:39,330 --> 01:55:39,597 2643 01:55:39,597 --> 01:55:39,664 2644 01:55:42,809 --> 01:55:43,176 >> WELCOME BACK. 2645 01:55:43,176 --> 01:55:44,711 I'D LIKE TO CALL THE MEETING 2646 01:55:44,711 --> 01:55:50,672 BACK TO ORDER AND INVITE 2647 01:55:50,672 --> 01:55:56,774 DR. CLAYTON. 2648 01:55:56,774 --> 01:56:00,044 >> I'M EXCITED FOR YOU TO SHARE 2649 01:56:00,044 --> 01:56:01,613 IN THE NEXT PRESENTATION AND 2650 01:56:01,613 --> 01:56:06,618 IT'S MY DISTINCT MRSH -- 2651 01:56:06,618 --> 01:56:07,785 PLEASURE TO INTRODUCE 2652 01:56:07,785 --> 01:56:12,457 DR. BERTAGNOLLI THE 17th 2653 01:56:12,457 --> 01:56:15,293 DIRECTOR AND SECOND WOMAN TO 2654 01:56:15,293 --> 01:56:16,828 HOLD THE POSITION. 2655 01:56:16,828 --> 01:56:19,364 SHE HAS A BIG JOB ON HER HANDS 2656 01:56:19,364 --> 01:56:20,398 BUT WE'RE THRILLED SHE'S AT THE 2657 01:56:20,398 --> 01:56:22,667 HELM AND EXCITED FOR ALL THE 2658 01:56:22,667 --> 01:56:23,935 WORK SHE WILL BE DOING. 2659 01:56:23,935 --> 01:56:25,370 BEFORE SHE WAS THE NIH DIRECTOR, 2660 01:56:25,370 --> 01:56:28,773 YOU KNOW SHE WAS THE 16th 2661 01:56:28,773 --> 01:56:30,174 DIRECTOR OF THE NATIONAL CANCER 2662 01:56:30,174 --> 01:56:32,010 INSTITUTE, BEFORE THAT AT 2663 01:56:32,010 --> 01:56:36,514 HARVARD MEDICAL SCHOOL AND DANA 2664 01:56:36,514 --> 01:56:40,451 FARBER INSTITUTE AND JOIN ME IN 2665 01:56:40,451 --> 01:56:44,022 GIVING A WARM WELCOME TO 2666 01:56:44,022 --> 01:56:46,691 DIRECTOR BERTAGNOLLI. 2667 01:56:46,691 --> 01:56:48,526 >> THANK YOU SO MUCH AND THANK 2668 01:56:48,526 --> 01:56:52,530 YOU, JANINE. 2669 01:56:52,530 --> 01:56:53,965 I'M THRILLED TO BE WITH ALL OF 2670 01:56:53,965 --> 01:56:54,198 YOU. 2671 01:56:54,198 --> 01:56:56,534 IT'S A 60th MEETING OF THIS 2672 01:56:56,534 --> 01:57:00,505 IMPORTANT ADVISORY COMMITTEE. 2673 01:57:00,505 --> 01:57:03,908 THAT'S FABULOUS. 2674 01:57:03,908 --> 01:57:05,910 I'M GOING TO START WITH 2675 01:57:05,910 --> 01:57:09,914 INTRODUCING MYSELF AND A LITTLE 2676 01:57:09,914 --> 01:57:14,719 BIT ABOUT MY BACKGROUND BECAUSE 2677 01:57:14,719 --> 01:57:18,423 IT REFLECTS ON VISION FOR NIH 2678 01:57:18,423 --> 01:57:20,525 AND THOUGHTS ABOUT THE SUPPORT 2679 01:57:20,525 --> 01:57:24,529 ACROSS ALL OF NIH FOR WOMEN'S 2680 01:57:24,529 --> 01:57:24,896 HEALTH RESEARCH. 2681 01:57:24,896 --> 01:57:27,098 SO, ME, BY THE WAY THIS IS ME IN 2682 01:57:27,098 --> 01:57:29,834 THE OPERATING ROOM AT THE 2683 01:57:29,834 --> 01:57:32,370 CLINICAL CENTER WITH STEPHANIE 2684 01:57:32,370 --> 01:57:36,040 GOSS MY FORMER POSTDOC AND 2685 01:57:36,040 --> 01:57:37,475 FELLOWSHIP TRAINEE AND I NOW I 2686 01:57:37,475 --> 01:57:38,776 GET TO BE HER FIRST ASSISTANT. 2687 01:57:38,776 --> 01:57:40,578 IT'S GLORIOUS HERE. 2688 01:57:40,578 --> 01:57:41,612 YOU ASK IF I GET TO THE 2689 01:57:41,612 --> 01:57:44,382 OPERATING ROOM, I DO BUT I'M THE 2690 01:57:44,382 --> 01:57:46,150 ASSISTANT NOW AND MY FORMER 2691 01:57:46,150 --> 01:57:48,519 TRAINEE IS THE TEACHER. 2692 01:57:48,519 --> 01:57:50,988 IT'S GREAT. 2693 01:57:50,988 --> 01:57:53,257 I'M HONORED TO BE AS OF NOVEMBER 2694 01:57:53,257 --> 01:57:55,159 OF LAST YEAR THE 17th DIRECTOR 2695 01:57:55,159 --> 01:57:58,229 OF NIH BUT STARTED OUT IN A 2696 01:57:58,229 --> 01:57:59,497 DIFFERENT PLACE ON THE LEFT. 2697 01:57:59,497 --> 01:58:01,999 I GREW UP IN A RANCH IN WYOMING 2698 01:58:01,999 --> 01:58:05,603 WHERE MY FAMILY STILL LIVES. 2699 01:58:05,603 --> 01:58:07,472 NEAREST HOSPITAL ACTUALLY THE 2700 01:58:07,472 --> 01:58:08,506 NEAREST DOCTOR'S OFFICE IS 100 2701 01:58:08,506 --> 01:58:10,475 MILES AWAY. 2702 01:58:10,475 --> 01:58:12,510 AND IT'S 18 MILES OF UNPAVED 2703 01:58:12,510 --> 01:58:14,145 DIRT ROAD JUST TO GET TO 2704 01:58:14,145 --> 01:58:14,479 PAVEMENT. 2705 01:58:14,479 --> 01:58:17,281 SO IT'S REALLY QUITE A WAYS AWAY 2706 01:58:17,281 --> 01:58:17,849 FROM BETHESDA. 2707 01:58:17,849 --> 01:58:20,451 IN MY CHOICE OF CAREER THOUGH 2708 01:58:20,451 --> 01:58:22,687 EVEN FROM WYOMING I WAS INSPIRED 2709 01:58:22,687 --> 01:58:25,990 BY MY UNCLE WHO'S A FAMILY 2710 01:58:25,990 --> 01:58:28,092 PRACTITIONER WHO TRAVELED ACROSS 2711 01:58:28,092 --> 01:58:29,227 THE ENTIRE STATE OF WYOMING 2712 01:58:29,227 --> 01:58:30,762 TAKING CARE OF VETERANS. 2713 01:58:30,762 --> 01:58:32,363 I ATTENDED PRINCETON UNIVERSITY 2714 01:58:32,363 --> 01:58:33,765 AND CAME BACK WEST TO MEDICAL 2715 01:58:33,765 --> 01:58:35,366 SCHOOL TO THE UNIVERSITY OF UTAH 2716 01:58:35,366 --> 01:58:37,769 WHICH WAS MY STATE SCHOOL 2717 01:58:37,769 --> 01:58:39,070 BECAUSE WYOMING DOESN'T HAVE AI 2718 01:58:39,070 --> 01:58:41,739 MEDICAL SCHOOL SO UTAH HAS TO 2719 01:58:41,739 --> 01:58:43,741 TAKE US REFUGEES IN. 2720 01:58:43,741 --> 01:58:46,744 AND IN MEDICAL SCHOOL I WAS 2721 01:58:46,744 --> 01:58:48,146 REALLY FASCINATED BY IMMUNOLOGY. 2722 01:58:48,146 --> 01:58:50,748 I THOUGHT I WAS GOING TO BE AN 2723 01:58:50,748 --> 01:58:52,049 INTERNIST SPECIALIZING IN 2724 01:58:52,049 --> 01:58:53,417 IMMUNOLOGY AND THEN I WALKED 2725 01:58:53,417 --> 01:58:56,020 INTO AN OPERATING ROOM AND EVERY 2726 01:58:56,020 --> 01:58:59,791 SURGEON YOU MEET ONCE YOU ARE IN 2727 01:58:59,791 --> 01:59:04,529 THAT ENVIRONMENT IF YOU'RE A 2728 01:59:04,529 --> 01:59:05,663 SURGEON THAT'S THE ONLY PLACE 2729 01:59:05,663 --> 01:59:07,765 YOU WANT TO BE SO THAT WAS IT. 2730 01:59:07,765 --> 01:59:10,635 I WAS FORTUNATE TO TRAIN IN 2731 01:59:10,635 --> 01:59:14,605 BRIGHAM AND WOMEN'S HOSPITAL AND 2732 01:59:14,605 --> 01:59:15,873 HARVARD WHERE SERIOUS 2733 01:59:15,873 --> 01:59:17,175 FUNDAMENTAL RESEARCH WAS PART OF 2734 01:59:17,175 --> 01:59:17,441 TRAINING. 2735 01:59:17,441 --> 01:59:25,149 DOESN'T MATTER IF YOU WERE A 2736 01:59:25,149 --> 01:59:26,984 SURGEON OR NOT AND DID A 2737 01:59:26,984 --> 01:59:28,452 TRAINING IN IMMUNOLOGY. 2738 01:59:28,452 --> 01:59:30,688 I KEPT UP THAT INTEREST. 2739 01:59:30,688 --> 01:59:35,493 DURING MY RESIDENCY I MET A 2740 01:59:35,493 --> 01:59:36,928 PATIENT WITH RARE DISEASE CAUSED 2741 01:59:36,928 --> 01:59:39,330 BY A GERM LINE MUTATION OF THE 2742 01:59:39,330 --> 01:59:40,198 APC GENE. 2743 01:59:40,198 --> 01:59:42,333 REALLY FASCINATED BY THIS 2744 01:59:42,333 --> 01:59:46,304 PATIENT AND MORE SO BY THIS 2745 01:59:46,304 --> 01:59:48,306 UNBELIEVABLY LOVELY YOUNG MAN 2746 01:59:48,306 --> 01:59:52,877 WHO DIED MUCH A VERY LARGE 2747 01:59:52,877 --> 01:59:55,847 INTERABDOMINAL DESMOID TUMOR. 2748 01:59:55,847 --> 01:59:59,116 IT LOOKS LIKE A NASTY 2749 01:59:59,116 --> 02:00:02,019 INFLAMMATORY REACTION AND LED ME 2750 02:00:02,019 --> 02:00:06,657 TO BE INTERESTED IN INFLAMMATION 2751 02:00:06,657 --> 02:00:11,195 AND TUMORIGENESIS AND LOOKED AT 2752 02:00:11,195 --> 02:00:14,632 DRIVERS OF TUMOR FORMATION IN 2753 02:00:14,632 --> 02:00:14,899 FAP. 2754 02:00:14,899 --> 02:00:18,870 WE LOOKED AT NOW NON-STEROIDAL 2755 02:00:18,870 --> 02:00:20,905 INFLAMMATORY DRUGS CAN INHIBIT 2756 02:00:20,905 --> 02:00:22,607 TUMOR FORMATION AND REVERSE THE 2757 02:00:22,607 --> 02:00:24,709 EFFECTS OF APC MUTATION IN THE 2758 02:00:24,709 --> 02:00:24,976 GUT. 2759 02:00:24,976 --> 02:00:27,278 THIS IS IMPORTANT BECAUSE 85% OF 2760 02:00:27,278 --> 02:00:32,016 REGULAR OLD SPORADIC COLORECTAL 2761 02:00:32,016 --> 02:00:34,518 CANCER STARTED BY AN IDENTICAL 2762 02:00:34,518 --> 02:00:39,657 DEFECT CREATED BY ABNORMAL APC 2763 02:00:39,657 --> 02:00:41,025 SIGNALLING. 2764 02:00:41,025 --> 02:00:42,760 IF WE COULD ARGUE OUT THE RARE 2765 02:00:42,760 --> 02:00:45,930 DISEASE WE CAN DO A LOT OF WITH 2766 02:00:45,930 --> 02:00:48,866 COLORECTAL CANCER. 2767 02:00:48,866 --> 02:00:54,038 WE ADD -- HAD AN ANIMAL MODEL 2768 02:00:54,038 --> 02:00:56,407 AT NEW YORK PRESBYTERIAN AND 2769 02:00:56,407 --> 02:01:02,013 CONTINUED AT DANA HARBOR AND 2770 02:01:02,013 --> 02:01:04,482 BRIGHAM AND WOMEN'S HOSPITAL AND 2771 02:01:04,482 --> 02:01:07,818 EVENTUALLY OUR DRUGS INHIBITING 2772 02:01:07,818 --> 02:01:10,087 TUMORS LED TO STUDY FOR 2773 02:01:10,087 --> 02:01:13,991 PREVENTION OF COLORECTAL CANCER 2774 02:01:13,991 --> 02:01:17,461 PREVENTING ADENOMAS WITH COX 2 2775 02:01:17,461 --> 02:01:18,095 INHIBI 2776 02:01:18,095 --> 02:01:18,396 INHIBITORS. 2777 02:01:18,396 --> 02:01:22,066 I SUSPECT MANY KNOW THE ING 2778 02:01:22,066 --> 02:01:22,466 PUNCH LINE THERE. 2779 02:01:22,466 --> 02:01:26,003 FOR PEOPLE AT HIGH RISK OF 2780 02:01:26,003 --> 02:01:28,606 COLORECTAL CANCERS THE COX 2 2781 02:01:28,606 --> 02:01:37,281 INHIBITOR PREVENTED HIGH RISK 2782 02:01:37,281 --> 02:01:42,219 ADD ADENOMA FORMATION AND DRUGS 2783 02:01:42,219 --> 02:01:44,021 CAUSED NOT PREVIOUSLY KNOWN 2784 02:01:44,021 --> 02:01:50,594 CARDIOVASCULAR TEX TOXICITY ANDW 2785 02:01:50,594 --> 02:01:52,330 WE'RE STALLED IN OUR EFFORT TO 2786 02:01:52,330 --> 02:01:53,297 TREAT FOR CANCER PREVENTION BUT 2787 02:01:53,297 --> 02:01:58,669 KNOW MORE ABOUT THE BIOLOGY OF 2788 02:01:58,669 --> 02:02:09,213 WHAT THIS MEANS IT WAS CLEAR IT 2789 02:02:13,551 --> 02:02:20,458 WASN'T TO GET US EVERYTHING WE 2790 02:02:20,458 --> 02:02:21,025 THESE 2791 02:02:21,025 --> 02:02:22,460 WERE GOING TO DO MORE TRIALS AND 2792 02:02:22,460 --> 02:02:25,162 I BECAME FOCUSSED ON BIOMEDICALS 2793 02:02:25,162 --> 02:02:30,668 IN CLINICAL TRIALS AND LED TO AN 2794 02:02:30,668 --> 02:02:36,140 INTEREST IN BETTER DIAGNOSTICS 2795 02:02:36,140 --> 02:02:37,641 AND BETTER DATA LEADING TO 2796 02:02:37,641 --> 02:02:41,679 INTEREST TO OTHER COLLABORATE 2797 02:02:41,679 --> 02:02:43,414 MAKING USE OF ELECTRONIC HEALTH 2798 02:02:43,414 --> 02:02:45,249 RECORD AND INCREASINGLY 2799 02:02:45,249 --> 02:02:47,651 ARTIFICIAL INTELLIGENCE AND 2800 02:02:47,651 --> 02:02:48,252 MACHINE LEARNING METHODS TO 2801 02:02:48,252 --> 02:02:50,021 UNDERSTAND DISEASE IN WAYS TO 2802 02:02:50,021 --> 02:02:51,088 ALLOW US TO DISCOVER 2803 02:02:51,088 --> 02:02:57,728 PATHOBIOLOGY AND TREATMENT. 2804 02:02:57,728 --> 02:03:01,298 I CONTINUED ON AT THE NCI 2805 02:03:01,298 --> 02:03:04,301 STARTING SIMILAR PROJECTS JUST 2806 02:03:04,301 --> 02:03:06,837 FIVE WEEKS AFTER TAKING OVER AS 2807 02:03:06,837 --> 02:03:08,472 DIRECT OF THE NIH WAS DIAGNOSED 2808 02:03:08,472 --> 02:03:14,512 WITH EARLY STAGE BREAST CANCER. 2809 02:03:14,512 --> 02:03:16,680 I GOT TO PARTICIPATE AS A 2810 02:03:16,680 --> 02:03:20,918 PATIENT PARTICIPANT INSTEAD OF 2811 02:03:20,918 --> 02:03:21,485 RESEARCHER. 2812 02:03:21,485 --> 02:03:22,920 FORTUNATELY MY PROGNOSIS IS 2813 02:03:22,920 --> 02:03:24,455 EXCELLENT AND I WILL SAY I 2814 02:03:24,455 --> 02:03:27,324 LOOKED AT IT AND EVERY SINGLE 2815 02:03:27,324 --> 02:03:28,492 TREATMENT THAT I AM RECEIVING 2816 02:03:28,492 --> 02:03:30,194 THAT IS LEADING TO SUCH GREAT 2817 02:03:30,194 --> 02:03:31,429 SUCCESS IN ME PERSONALLY WAS 2818 02:03:31,429 --> 02:03:41,672 FUNDED BY NIH. 2819 02:03:42,306 --> 02:03:44,141 THERE'S ROUGHLY 1040 WOMEN WHO 2820 02:03:44,141 --> 02:03:46,811 CONTRIBUTED AS RESEARCH 2821 02:03:46,811 --> 02:03:47,078 SUBJECTS. 2822 02:03:47,078 --> 02:03:48,379 I'M GRATEFUL TO ALL THE WOMEN 2823 02:03:48,379 --> 02:03:49,580 FOR BEING ABLE TO MAKE IT 2824 02:03:49,580 --> 02:03:50,247 POSSIBLE FOR ME TO HAVE A GOOD 2825 02:03:50,247 --> 02:03:52,216 RESULT. 2826 02:03:52,216 --> 02:03:54,552 SO IN SUMMARY, MY LIFE 2827 02:03:54,552 --> 02:03:56,787 EXPERIENCES I THINK HAVE GIVEN 2828 02:03:56,787 --> 02:04:02,893 ME A POWERFUL SENSE OF THE 2829 02:04:02,893 --> 02:04:04,528 TRANSFORMATIVE PATIENT OF 2830 02:04:04,528 --> 02:04:08,532 RESEARCH AND THE CRITICAL 2831 02:04:08,532 --> 02:04:09,500 IMPORTANCE GOING TO WYOMING 2832 02:04:09,500 --> 02:04:12,269 WHERE THE HOSPITAL WAS OVER 100 2833 02:04:12,269 --> 02:04:13,370 MILES AWAY THE CRITICAL 2834 02:04:13,370 --> 02:04:14,672 IMPORTANCE OF ACCESS TO ALL 2835 02:04:14,672 --> 02:04:16,507 PEOPLE FOR RESEARCH AND ITS 2836 02:04:16,507 --> 02:04:20,644 BENEFITS. 2837 02:04:20,644 --> 02:04:23,781 NOW, AS NIH DIRECTOR THE TEAM 2838 02:04:23,781 --> 02:04:26,016 HERE THE AMAZING TEAM OF 27 2839 02:04:26,016 --> 02:04:30,020 INSTITUTES AND CENTERS AT NIH 2840 02:04:30,020 --> 02:04:31,455 THINK ABOUT THINGS OVER ALL IN 2841 02:04:31,455 --> 02:04:33,924 TERMS OF WHAT WE NEED TO DO FOR 2842 02:04:33,924 --> 02:04:36,160 HEALTH AND ONE OF THE THINGS 2843 02:04:36,160 --> 02:04:37,995 THAT CONCERNS US ALL THE MOST IS 2844 02:04:37,995 --> 02:04:39,263 THE HEALTH OF THE 2845 02:04:39,263 --> 02:04:40,598 U.S. POPULATION IS NOT HEADING 2846 02:04:40,598 --> 02:04:41,198 IN THE RIGHT DIRECTION RIGHT 2847 02:04:41,198 --> 02:04:43,100 NOW. 2848 02:04:43,100 --> 02:04:45,536 OUR LIFE EXPECTANCY IS LOW 2849 02:04:45,536 --> 02:04:47,505 COMPARED TO PEER NATIONS. 2850 02:04:47,505 --> 02:04:50,774 YOU COULD SEE WE'RE BELOW 2851 02:04:50,774 --> 02:04:52,209 CANADA, FRANCE BELOW CHINA. 2852 02:04:52,209 --> 02:04:54,512 OUR LIFE EXPECTANCY IS THE PLACE 2853 02:04:54,512 --> 02:04:58,582 WHERE VIETNAM IS CURRENTLY. 2854 02:04:58,582 --> 02:05:00,317 THIS IS NOT A PANDEMIC ERA 2855 02:05:00,317 --> 02:05:00,851 ISSUE. 2856 02:05:00,851 --> 02:05:03,020 LIFE EXPECTANCY DROPPED 2857 02:05:03,020 --> 02:05:05,723 DRAMATICALLY DURING THE PANDEMIC 2858 02:05:05,723 --> 02:05:07,458 OF COURSE AND IT'S SEEN A BIT OF 2859 02:05:07,458 --> 02:05:08,859 A REBOUND LIKE ALL THINGS BUT WE 2860 02:05:08,859 --> 02:05:10,961 STILL HAVEN'T MADE UP FOR THE 2861 02:05:10,961 --> 02:05:12,730 LOSSES THAT WERE HAPPENING 2862 02:05:12,730 --> 02:05:17,968 BEFORE THE PANDEMIC HIT. 2863 02:05:17,968 --> 02:05:20,504 AND NEXT SLIDE, AND OUR LIFE 2864 02:05:20,504 --> 02:05:22,406 EXPECTANCY IS LOW COMPARED TO 2865 02:05:22,406 --> 02:05:24,008 PEER COUNTRIES THOUGH WE SPEND 2866 02:05:24,008 --> 02:05:25,876 SO MUCH MORE ON OUR HEALTH 2867 02:05:25,876 --> 02:05:26,110 SYSTEM. 2868 02:05:26,110 --> 02:05:28,479 I SEE TWO MAJOR CHALLENGES THAT 2869 02:05:28,479 --> 02:05:30,748 NIH NEEDS TO RESPOND TO IN THIS 2870 02:05:30,748 --> 02:05:30,981 REGARD. 2871 02:05:30,981 --> 02:05:34,084 FIRST, MANY COMMUNITIES ARE 2872 02:05:34,084 --> 02:05:36,420 UNDER REPRESENTED IN RESEARCH. 2873 02:05:36,420 --> 02:05:37,354 DATA IS LACKING FOR POPULATIONS 2874 02:05:37,354 --> 02:05:41,525 THAT ARE OLDER, UNINSURED, 2875 02:05:41,525 --> 02:05:43,294 BELONGING TO MINORITY GROUPS OR 2876 02:05:43,294 --> 02:05:44,995 LIVE IN RURAL LOCATIONS AND 2877 02:05:44,995 --> 02:05:47,965 SADLY, THESE ARE THE COMMUNITIES 2878 02:05:47,965 --> 02:05:50,034 THAT ARE DISPROPORTIONATELY 2879 02:05:50,034 --> 02:05:51,769 AFFECTED BY THE VERY ISSUES THAT 2880 02:05:51,769 --> 02:05:53,637 ARE CAUSING OUR LIFE EXPECTANCY 2881 02:05:53,637 --> 02:05:54,238 TO DECLINE. 2882 02:05:54,238 --> 02:05:59,276 THIS LIFE EXPECTANCY IS NOT DUE 2883 02:05:59,276 --> 02:06:02,046 TO CANCER TREATMENT, FRANKLY, 2884 02:06:02,046 --> 02:06:05,649 IT'S DUE TO AN INCREASED RATE, 2885 02:06:05,649 --> 02:06:08,185 INCREASE PROBLEMS WITH DRUG 2886 02:06:08,185 --> 02:06:13,991 POISONING, ALCOHOLISM, SUICIDE, 2887 02:06:13,991 --> 02:06:15,960 MATERNAL DEATHS AND DEATH AND A 2888 02:06:15,960 --> 02:06:19,163 SLOWING -- SIGNIFICANT SLOWING 2889 02:06:19,163 --> 02:06:21,799 OF PROGRESS TOWARDS PREVENTION 2890 02:06:21,799 --> 02:06:25,669 OF CARDIO METABOLIC DISEASE, IN 2891 02:06:25,669 --> 02:06:27,638 OTHER WORDS, THE OBESITY 2892 02:06:27,638 --> 02:06:27,905 EPIDEMIC. 2893 02:06:27,905 --> 02:06:30,474 THE SAME ISSUES RESPONSIBLE FOR 2894 02:06:30,474 --> 02:06:33,244 OUR DECLINE IN LIFE EXPECTANCY 2895 02:06:33,244 --> 02:06:34,745 ARE DISPROPORTIONATELY PRESENT 2896 02:06:34,745 --> 02:06:36,513 WITHIN COMMUNITIES THAT ARE LEFT 2897 02:06:36,513 --> 02:06:39,183 OUT OF OUR RESEARCH. 2898 02:06:39,183 --> 02:06:41,452 AND THEN SO WE'RE MISSING THE 2899 02:06:41,452 --> 02:06:43,454 PEOPLE WE NEED TO MAKE PROGRESS 2900 02:06:43,454 --> 02:06:46,257 ON THIS REALLY IMPORTANT HEALTH 2901 02:06:46,257 --> 02:06:50,027 ISSUES BUT WE'RE ALSO NOT 2902 02:06:50,027 --> 02:06:51,228 EFFECTIVELY HARNESSING RESEARCH 2903 02:06:51,228 --> 02:06:52,429 KNOWLEDGE RIGHT NOW. 2904 02:06:52,429 --> 02:06:53,530 FUNDAMENTALLY, FOR ALL THE 2905 02:06:53,530 --> 02:06:55,366 WEALTH OF DATA WE'RE ABLE TO 2906 02:06:55,366 --> 02:06:57,234 COLLECT FROM OUR BASIC RESEARCH 2907 02:06:57,234 --> 02:06:59,937 LABORATORIES ALL THE WAY TO OUR 2908 02:06:59,937 --> 02:07:00,938 CLINICS, WE STILL LACK 2909 02:07:00,938 --> 02:07:02,039 SUFFICIENT DATA TO GUIDE 2910 02:07:02,039 --> 02:07:03,474 CLINICAL CARE AND THE NEXT SLIDE 2911 02:07:03,474 --> 02:07:05,909 IS VERY SOBERING. 2912 02:07:05,909 --> 02:07:08,646 THIS IS FROM THE FIELD OF 2913 02:07:08,646 --> 02:07:10,881 ONCOLOGY, THE SAME ALMOST EXACT 2914 02:07:10,881 --> 02:07:13,851 SUPER IMPOSABLE FIGURE COULD BE 2915 02:07:13,851 --> 02:07:15,886 FOR CARDIOVASCULAR DISEASE I 2916 02:07:15,886 --> 02:07:17,521 FRANKLY DON'T KNOW IF IT'S EVEN 2917 02:07:17,521 --> 02:07:18,989 BEEN STUDIED FOR OTHER DISEASES. 2918 02:07:18,989 --> 02:07:21,258 WHEN YOU LOOK AT THIS YOU CAN 2919 02:07:21,258 --> 02:07:23,394 SEE THESE ARE RECOMMENDATIONS OF 2920 02:07:23,394 --> 02:07:27,698 EXPERT PANELS FOR TREATMENT OF 2921 02:07:27,698 --> 02:07:29,400 CANCERS, GUIDELINE TREATMENT OF 2922 02:07:29,400 --> 02:07:29,933 CANCERS. 2923 02:07:29,933 --> 02:07:33,937 ONLY 7% OF ALL OF THOSE 2924 02:07:33,937 --> 02:07:34,805 GUIDELINE RECOMMENDATIONS WERE 2925 02:07:34,805 --> 02:07:38,042 BASED ON THE HIGHEST LEVEL OF 2926 02:07:38,042 --> 02:07:38,309 EVIDENCE. 2927 02:07:38,309 --> 02:07:41,211 THE VAST MAJORITY IS BASED ON 2928 02:07:41,211 --> 02:07:44,014 LOWER LEVELS OF EVIDENCE, SOLID 2929 02:07:44,014 --> 02:07:47,584 OBSERVATIONAL DATA, MAYBE SINGLE 2930 02:07:47,584 --> 02:07:49,887 EARLIER STAGE CLINICAL TRIALS 2931 02:07:49,887 --> 02:07:52,189 BUT WITHIN CONSENSUS FOR THE 2932 02:07:52,189 --> 02:07:52,389 GROUP. 2933 02:07:52,389 --> 02:07:53,457 THAT'S MOST OF THE DISEASE AND 2934 02:07:53,457 --> 02:07:57,494 YOU CAN SEE HERE WE STILL HAVE 2935 02:07:57,494 --> 02:07:58,462 RECOMMENDATIONS THAT ARE BASED 2936 02:07:58,462 --> 02:08:00,364 ON MUCH LOWER LEVEL. 2937 02:08:00,364 --> 02:08:03,367 AND THE BIG PROBLEM WITH THIS IS 2938 02:08:03,367 --> 02:08:04,535 THE EVIDENCE PROGRESS HAS NOT 2939 02:08:04,535 --> 02:08:06,770 CHANGED IN A DECADE. 2940 02:08:06,770 --> 02:08:09,506 WE HAVE NOT MADE PROGRESS. 2941 02:08:09,506 --> 02:08:10,741 THIS IS THE DATA THAT OUR 2942 02:08:10,741 --> 02:08:14,044 DOCTORS AND PATIENTS USE TO MAKE 2943 02:08:14,044 --> 02:08:15,346 LIFE-ALTERING DECISIONS IN 2944 02:08:15,346 --> 02:08:18,716 CLINIC EVERY SINGLE DAY. 2945 02:08:18,716 --> 02:08:20,751 AND IT'S NOT NEARLY AS 2946 02:08:20,751 --> 02:08:22,286 COMPREHENSIVE AND RIGOROUS AS WE 2947 02:08:22,286 --> 02:08:22,986 REALLY NEED. 2948 02:08:22,986 --> 02:08:26,390 SO WHAT ARE WE GOING TO DO ABOUT 2949 02:08:26,390 --> 02:08:28,525 IT? 2950 02:08:28,525 --> 02:08:29,293 WHAT CAN NIH DO? 2951 02:08:29,293 --> 02:08:31,161 AT NIH WE SEEK FUNDAMENTAL 2952 02:08:31,161 --> 02:08:33,464 KNOWLEDGE ABOUT THE NATURE AND 2953 02:08:33,464 --> 02:08:35,132 BEHAVIOR OF ALL LIVING SYSTEMS. 2954 02:08:35,132 --> 02:08:39,503 THEN WE STRIVE TO ACQUIRE THAT 2955 02:08:39,503 --> 02:08:42,272 KNOWLEDGE FOR SUPPORT OF BASIC, 2956 02:08:42,272 --> 02:08:43,340 TRANSLATIONAL AND CLINICAL 2957 02:08:43,340 --> 02:08:44,041 RESEARCH AND ALSO HAVE A 2958 02:08:44,041 --> 02:08:45,509 CRITICAL ROLE IN HELPING TO 2959 02:08:45,509 --> 02:08:48,512 TRAIN AND SUPPORT A CREATIVE AND 2960 02:08:48,512 --> 02:08:51,014 DIVERSE SCIENTIFIC WORKFORCE. 2961 02:08:51,014 --> 02:08:55,686 SO AMONG OUR MAIN GUIDING 2962 02:08:55,686 --> 02:08:57,521 PRINCIPLES AT NIH THE FIRST ONE 2963 02:08:57,521 --> 02:09:01,392 IS OUR WORK NOT FINISHED WHEN WE 2964 02:09:01,392 --> 02:09:02,226 DELIVER SCIENTIFIC DISCOVERIES. 2965 02:09:02,226 --> 02:09:04,561 IT'S WHEN ALL PEOPLE ARE LIVING 2966 02:09:04,561 --> 02:09:06,864 LONG AND HEALTHY LIVES AND THAT 2967 02:09:06,864 --> 02:09:08,499 NEEDS TO BE A LENS THROUGH WHICH 2968 02:09:08,499 --> 02:09:09,967 WE VIEW EVERYTHING. 2969 02:09:09,967 --> 02:09:12,436 WE SHOULD CELEBRATE OUR 2970 02:09:12,436 --> 02:09:12,703 SUCCESSES. 2971 02:09:12,703 --> 02:09:13,070 WE HAVE MANY. 2972 02:09:13,070 --> 02:09:15,939 BUT WE HAVE TO REMAIN VERY 2973 02:09:15,939 --> 02:09:16,673 HUMBLE IN THE FACE OF HUMAN 2974 02:09:16,673 --> 02:09:18,742 SUFFERING. 2975 02:09:18,742 --> 02:09:20,644 AND WE HAVE TO APPROACH OUR WORK 2976 02:09:20,644 --> 02:09:21,612 WITH GREAT URGENCY BECAUSE 2977 02:09:21,612 --> 02:09:24,782 PEOPLE ARE COUNTING ON US. 2978 02:09:24,782 --> 02:09:26,316 HERE'S ANOTHER GUIDING 2979 02:09:26,316 --> 02:09:27,851 PRINCIPLE, NIH RESEARCH 2980 02:09:27,851 --> 02:09:30,120 ENCOMPASSES THE LABORATORY, THE 2981 02:09:30,120 --> 02:09:31,722 CLINIC BUT IT DOES NOT STOP AT 2982 02:09:31,722 --> 02:09:35,359 THE DOOR TO THE DOCTOR'S OFFICE. 2983 02:09:35,359 --> 02:09:40,798 IT 2984 02:09:40,798 --> 02:09:41,965 FUNDAMENTAL SCIENCE REMAINS 2985 02:09:41,965 --> 02:09:42,399 CRITICAL. 2986 02:09:42,399 --> 02:09:44,034 WE'RE LEARNING SO MUCH ABOUT 2987 02:09:44,034 --> 02:09:45,269 HUMAN BIOLOGY IN OUR BASIC 2988 02:09:45,269 --> 02:09:46,270 RESEARCH LABORATORIES. 2989 02:09:46,270 --> 02:09:48,005 AND THIS BIG RUSH OF INFORMATION 2990 02:09:48,005 --> 02:09:51,508 COMES IN FROM THOSE LABORATORIES 2991 02:09:51,508 --> 02:09:52,943 EVERY DAY. 2992 02:09:52,943 --> 02:09:54,678 I SEE THE MANUSCRIPTS COME IN 2993 02:09:54,678 --> 02:09:56,447 DAY BY DAY, BELIEVE IT OR NOT. 2994 02:09:56,447 --> 02:10:01,418 I HAVE A STEADY STREAM WHICH IS 2995 02:10:01,418 --> 02:10:03,787 WONDERFUL BUT WE MUST BE MORE 2996 02:10:03,787 --> 02:10:07,191 EFFECTIVE CONNECTING WHAT WE'RE 2997 02:10:07,191 --> 02:10:08,392 LEARNING, UNDERSTANDING 2998 02:10:08,392 --> 02:10:09,593 INTERPLAY BETWEEN THE GENES WE 2999 02:10:09,593 --> 02:10:14,631 INHERIT AND ENVIRONMENTAL AND 3000 02:10:14,631 --> 02:10:15,632 SOCIETAL FACTORS THAT SURROUND 3001 02:10:15,632 --> 02:10:16,934 US BEGINNING BEFORE BIRTH AND 3002 02:10:16,934 --> 02:10:18,135 CONNECTING THAT KNOWLEDGE TO 3003 02:10:18,135 --> 02:10:19,336 EVERYDAY LIFE IN CLINICAL 3004 02:10:19,336 --> 02:10:19,803 PRACTICE. 3005 02:10:19,803 --> 02:10:22,840 WE NEED TO MAKE SURE THAT THE 3006 02:10:22,840 --> 02:10:24,274 BIOLOGICAL INSIGHTS IDENTIFIED 3007 02:10:24,274 --> 02:10:26,009 IN LABORATORIES ARE PURSUED IN 3008 02:10:26,009 --> 02:10:27,644 WAYS THAT SPEED THEIR 3009 02:10:27,644 --> 02:10:29,446 APPLICATION TO IMPROVE THE 3010 02:10:29,446 --> 02:10:30,848 CIRCUMSTANCES OF REAL PEOPLE. 3011 02:10:30,848 --> 02:10:35,552 OUR CLINICAL RESEARCH NEEDS TO 3012 02:10:35,552 --> 02:10:36,420 BE EFFICIENT, INCLUSIVE, AND 3013 02:10:36,420 --> 02:10:37,754 RESPONSIVE TO THE NEEDS OF 3014 02:10:37,754 --> 02:10:38,021 PATIENTS. 3015 02:10:38,021 --> 02:10:40,357 NEXT SLIDE. 3016 02:10:40,357 --> 02:10:43,093 AND THEN HERE'S THE LAST MAIN 3017 02:10:43,093 --> 02:10:46,396 GUIDING PRINCIPLE. 3018 02:10:46,396 --> 02:10:48,465 PROGRESS IS ACCELERATED, WHEN 3019 02:10:48,465 --> 02:10:49,666 ADVANCED SCIENTIFIC METHODS, 3020 02:10:49,666 --> 02:10:59,543 WHICH IS NEW DATA ANALYTICS LIKE 3021 02:10:59,543 --> 02:11:02,045 MACHINE LEARNING ARE FOR 3022 02:11:02,045 --> 02:11:03,914 EVERYONE AND ARE ADOPTED IN 3023 02:11:03,914 --> 02:11:05,249 CLINICAL CARE, WE'RE ONLY DONE 3024 02:11:05,249 --> 02:11:06,316 WHEN DISCOVERIES BENEFIT PEOPLE. 3025 02:11:06,316 --> 02:11:12,122 WE NEED TO MAKE SURE THAT OUR 3026 02:11:12,122 --> 02:11:12,723 TECHNOLOGY AND KNOWLEDGE, NOW 3027 02:11:12,723 --> 02:11:16,260 DEVELOPED TO THE POINT THAT WE 3028 02:11:16,260 --> 02:11:17,261 CAN DELIVER EVIDENCE-BASED 3029 02:11:17,261 --> 02:11:18,428 DATA-DRIVEN HEALTH TO EVERY 3030 02:11:18,428 --> 02:11:20,764 PATIENT, WE NEED TO MAKE THAT A 3031 02:11:20,764 --> 02:11:20,998 REALITY. 3032 02:11:20,998 --> 02:11:23,600 WE ALSO NEED TO TAKE THE 3033 02:11:23,600 --> 02:11:25,903 FEEDBACK LOOP. 3034 02:11:25,903 --> 02:11:27,871 OBSERVATIONS FROM CLINICAL CARE 3035 02:11:27,871 --> 02:11:30,707 SHOULD ROUTINELY INFORM OUR 3036 02:11:30,707 --> 02:11:35,946 EVIDENCE BASE, NOT IN AN AD HOC 3037 02:11:35,946 --> 02:11:36,780 AND EPISODIC MANNER. 3038 02:11:36,780 --> 02:11:38,248 ARTIFICIAL INTELLIGENCE AND 3039 02:11:38,248 --> 02:11:40,350 MACHINE LEARNING ARE REALLY 3040 02:11:40,350 --> 02:11:42,419 REVOLUTIONIZING WHAT IS POSSIBLE 3041 02:11:42,419 --> 02:11:43,520 FOR BIOMEDICAL RESEARCH AND 3042 02:11:43,520 --> 02:11:44,221 CLINICAL CARE. 3043 02:11:44,221 --> 02:11:46,924 I CAN SAY IT'S A MATTER OF PRIDE 3044 02:11:46,924 --> 02:11:48,091 WE HAVE MANY OUTSTAND 3045 02:11:48,091 --> 02:11:49,626 RESEARCHERS HERE AT NIH THAT 3046 02:11:49,626 --> 02:11:51,929 HAVE BEEN USING THOSE TECHNIQUES 3047 02:11:51,929 --> 02:11:54,031 FOR ALMOST TWO DECADES, SO THEY 3048 02:11:54,031 --> 02:11:55,666 ARE NOT NEW TO US. 3049 02:11:55,666 --> 02:11:58,201 THEY ARE THE NEW TO THE REST OF 3050 02:11:58,201 --> 02:12:01,371 THE WORLD THAT CAN NOW USE 3051 02:12:01,371 --> 02:12:04,775 ChatGPT, PROBABLY THE LEAST OF 3052 02:12:04,775 --> 02:12:07,311 THE METHODS THAT WE HAVE, TAKING 3053 02:12:07,311 --> 02:12:09,146 A MUCH CAUSAL APPROACH. 3054 02:12:09,146 --> 02:12:11,782 BUT IF WE'RE GOING TO REALIZE 3055 02:12:11,782 --> 02:12:13,684 THE POTENTIAL OF THESE NEW 3056 02:12:13,684 --> 02:12:15,485 TECHNOLOGICAL METHODS, WE NEED 3057 02:12:15,485 --> 02:12:21,091 TO INVEST IN A SECURE AND 3058 02:12:21,091 --> 02:12:22,159 SUSTAINABLE DATA SHARING 3059 02:12:22,159 --> 02:12:22,960 INFRASTRUCTURE. 3060 02:12:22,960 --> 02:12:25,462 SO, WHAT SHOULD NIH DO IN 3061 02:12:25,462 --> 02:12:26,330 PRACTICAL TERMS? 3062 02:12:26,330 --> 02:12:27,431 NEXT SLIDE. 3063 02:12:27,431 --> 02:12:29,533 WE NEED TO MAKE EVIDENCE-BASED 3064 02:12:29,533 --> 02:12:32,336 HEALTH CARE AVAILABLE TO ALL. 3065 02:12:32,336 --> 02:12:32,903 NEXT SLIDE. 3066 02:12:32,903 --> 02:12:34,905 I BELIEVE WE CAN DO THE MOST 3067 02:12:34,905 --> 02:12:39,142 GOOD BY PUSHING TO BETTER 3068 02:12:39,142 --> 02:12:41,712 INTEGRATE EVERYDAY CARE WITH 3069 02:12:41,712 --> 02:12:42,312 RESEARCH. 3070 02:12:42,312 --> 02:12:45,182 WE ESPECIALLY WANT TO FOCUS ON 3071 02:12:45,182 --> 02:12:45,983 PRIMARY CARE. 3072 02:12:45,983 --> 02:12:48,352 AND WE WANT TO EXTRACT BETTER 3073 02:12:48,352 --> 02:12:50,687 INFORMATION FROM DATA TO INFORM 3074 02:12:50,687 --> 02:12:52,155 CARE. 3075 02:12:52,155 --> 02:12:53,724 WHY PRIMARY CARE? 3076 02:12:53,724 --> 02:12:55,125 WE NEED TO MEET PEOPLE WHERE 3077 02:12:55,125 --> 02:12:56,994 THEY ALREADY RECEIVE CARE SO WE 3078 02:12:56,994 --> 02:12:58,962 CAN SUPPORT AND WE NEED TO 3079 02:12:58,962 --> 02:12:59,896 SUPPORT PRIMARY CARE PROVIDERS 3080 02:12:59,896 --> 02:13:01,031 WHO REALLY ARE ON THE FRONT 3081 02:13:01,031 --> 02:13:03,467 LINES OF HEALTH CARE AND ON THE 3082 02:13:03,467 --> 02:13:06,403 FRONT LINES OF SO MANY REALLY 3083 02:13:06,403 --> 02:13:08,271 CHALLENGING PROBLEMS THAT WE 3084 02:13:08,271 --> 02:13:10,340 NEED TO ATTACK, AGAIN I'LL GIVE 3085 02:13:10,340 --> 02:13:14,277 YOU THE LIST. 3086 02:13:14,277 --> 02:13:18,348 OBESITY, CARDIOVASCULAR RISK, 3087 02:13:18,348 --> 02:13:20,617 CANCER SCREENING, MENTAL HEALTH, 3088 02:13:20,617 --> 02:13:21,985 MANAGEMENT OF SUBSTANCE ABUSE, 3089 02:13:21,985 --> 02:13:24,488 AND ON AND ON. 3090 02:13:24,488 --> 02:13:27,190 THESE ARE PRIMARY CARE ISSUES. 3091 02:13:27,190 --> 02:13:30,293 WE HAVEN'T REALLY HAD A 3092 02:13:30,293 --> 02:13:32,996 COMPREHENSIVE FOCUS ON THAT 3093 02:13:32,996 --> 02:13:35,766 ENVIRONMENT AS A CENTER FOR 3094 02:13:35,766 --> 02:13:36,066 RESEARCH. 3095 02:13:36,066 --> 02:13:37,934 USING INNOVATIVE STUDY DESIGNS, 3096 02:13:37,934 --> 02:13:40,003 WE CAN INCREASE RESEARCH 3097 02:13:40,003 --> 02:13:41,438 CAPABILITIES TO ADDRESS THESE 3098 02:13:41,438 --> 02:13:42,939 URGENT HEALTH ISSUES, LIKE 3099 02:13:42,939 --> 02:13:44,608 METABOLIC DISORDERS AND MENTAL 3100 02:13:44,608 --> 02:13:46,910 HEALTH, WITH THE GOAL OF 3101 02:13:46,910 --> 02:13:50,514 IMPROVING OUR ABILITY TO PREVENT 3102 02:13:50,514 --> 02:13:50,747 DISEASE. 3103 02:13:50,747 --> 02:13:52,282 PEOPLE SAY THIS OFTEN. 3104 02:13:52,282 --> 02:13:54,084 WE WITHIN THE INSTITUTE, WE'RE 3105 02:13:54,084 --> 02:13:55,585 NOT THE NATIONAL INSTITUTE OF 3106 02:13:55,585 --> 02:13:55,819 DISEASE. 3107 02:13:55,819 --> 02:13:57,621 WE'RE THE NATIONAL INSTITUTES OF 3108 02:13:57,621 --> 02:14:00,724 HEALTH, AND THAT NEEDS TO BE OUR 3109 02:14:00,724 --> 02:14:01,158 FOCUS. 3110 02:14:01,158 --> 02:14:03,994 WE CAN BETTER UNDERSTAND -- ALSO 3111 02:14:03,994 --> 02:14:07,030 BETTER UNDERSTAND WHAT WORKS IN 3112 02:14:07,030 --> 02:14:08,799 TERMS OF IMPLEMENTATION. 3113 02:14:08,799 --> 02:14:11,001 MOST IMPORTANT, WE CAN DESIGN 3114 02:14:11,001 --> 02:14:12,636 STUDIES AND RESEARCH METHODS 3115 02:14:12,636 --> 02:14:15,238 THAT ALLOW US TO ADDRESS 3116 02:14:15,238 --> 02:14:16,907 QUESTIONS THAT ARE BROUGHT TO US 3117 02:14:16,907 --> 02:14:18,742 BY THE PRIMARY CARE PROVIDERS 3118 02:14:18,742 --> 02:14:21,511 AND THE PEOPLE THAT THEY SERVE. 3119 02:14:21,511 --> 02:14:24,448 RECOGNIZING THAT HEALTH CARE 3120 02:14:24,448 --> 02:14:25,549 PROVIDERS PARTICULARLY PRIMARY 3121 02:14:25,549 --> 02:14:27,751 CARE FACE HEAVY DEMANDS ON THEIR 3122 02:14:27,751 --> 02:14:30,220 TIME, WE CAN USE TOOLS LIKE THE 3123 02:14:30,220 --> 02:14:31,688 ELECTRONIC HEALTH RECORD TO 3124 02:14:31,688 --> 02:14:33,790 ENGAGE PEOPLE IN RESEARCH WITH 3125 02:14:33,790 --> 02:14:35,959 THEIR PERMISSION AND REDUCE THE 3126 02:14:35,959 --> 02:14:37,694 BURDENS OF DATA COLLECTION. 3127 02:14:37,694 --> 02:14:40,097 FINALLY, WE ALL ARE WORKING HARD 3128 02:14:40,097 --> 02:14:43,066 TOWARD OUR VISION OF A 3129 02:14:43,066 --> 02:14:44,701 DATA-DRIVEN SYSTEM IN WHICH 3130 02:14:44,701 --> 02:14:47,237 RESEARCH AND INSIGHT FROM 3131 02:14:47,237 --> 02:14:48,438 PATIENT CARE ARE CONSTANTLY 3132 02:14:48,438 --> 02:14:50,507 INFORMING ONE ANOTHER. 3133 02:14:50,507 --> 02:14:51,608 NEXT SLIDE. 3134 02:14:51,608 --> 02:14:52,609 IN ADDITION TO CONNECTING 3135 02:14:52,609 --> 02:14:54,344 PATIENT CARE TO RESEARCH WE NEED 3136 02:14:54,344 --> 02:14:55,779 TO HARNESS RESEARCH AND HEALTH 3137 02:14:55,779 --> 02:14:57,314 DATA. 3138 02:14:57,314 --> 02:15:00,617 WE HAVE AN ENORMOUS ABUNDANCE OF 3139 02:15:00,617 --> 02:15:01,451 DATA. 3140 02:15:01,451 --> 02:15:03,420 FEDERAL REGULATIONS REQUIRE THAT 3141 02:15:03,420 --> 02:15:04,855 NIH-FUNDED RESEARCHERS SHARE 3142 02:15:04,855 --> 02:15:05,856 THEIR DATA PUBLICLY. 3143 02:15:05,856 --> 02:15:08,258 SO OUR VISION IS TO INTEGRATE 3144 02:15:08,258 --> 02:15:10,694 DATA FROM BASIC AND SOCIAL 3145 02:15:10,694 --> 02:15:11,995 SCIENCE RESEARCH, FROM PUBLIC 3146 02:15:11,995 --> 02:15:13,864 HEALTH AND CLINICAL CARE. 3147 02:15:13,864 --> 02:15:17,467 INCREASE THE CAPACITY FOR DATA 3148 02:15:17,467 --> 02:15:17,701 HOSTING. 3149 02:15:17,701 --> 02:15:19,436 ENABLE LOW-COST ACCESS TO DATA 3150 02:15:19,436 --> 02:15:21,838 USING OPEN INDUSTRY DATA 3151 02:15:21,838 --> 02:15:22,339 STANDARDS. 3152 02:15:22,339 --> 02:15:25,342 AND SUPPORT BROAD ACCESS TO 3153 02:15:25,342 --> 02:15:26,743 ADVANCED ANALYTICS AND 3154 02:15:26,743 --> 02:15:28,278 COMPUTATIONAL POWER. 3155 02:15:28,278 --> 02:15:31,681 TO DO THIS, WE WILL EMPLOY A 3156 02:15:31,681 --> 02:15:32,816 FEDERATED ARCHITECTURE FOR DATA 3157 02:15:32,816 --> 02:15:35,519 SHARING, DON'T LOOK TO US TO 3158 02:15:35,519 --> 02:15:40,557 HAVE SOME GINORMOUS LAKE OF ALL 3159 02:15:40,557 --> 02:15:41,424 THE DATA FROM BIOMEDICAL 3160 02:15:41,424 --> 02:15:42,526 RESEARCH BUT INSTEAD KNOW WHERE 3161 02:15:42,526 --> 02:15:44,494 THESE DATA LIVE, WHO IS HOSTING 3162 02:15:44,494 --> 02:15:47,464 THEM, AND HOW TO BRING THEM 3163 02:15:47,464 --> 02:15:51,935 TOGETHER TO TEAMS TO ANSWER 3164 02:15:51,935 --> 02:15:53,136 IMPORTANT QUESTIONS. 3165 02:15:53,136 --> 02:15:55,872 AND THEN FINALLY WE ALSO NEED TO 3166 02:15:55,872 --> 02:15:56,640 PROVIDE EDUCATION AND WORKFORCE 3167 02:15:56,640 --> 02:15:59,709 DEVELOPMENT AS A PART OF THIS 3168 02:15:59,709 --> 02:16:02,412 DATA SHARING AND ABOVE ALL DATA 3169 02:16:02,412 --> 02:16:03,847 USE FOCUS. 3170 02:16:03,847 --> 02:16:04,548 NEXT SLIDE. 3171 02:16:04,548 --> 02:16:07,017 NOW I'D LIKE TO SHIFT GEARS AND 3172 02:16:07,017 --> 02:16:09,219 TALK ABOUT WOMEN'S HEALTH 3173 02:16:09,219 --> 02:16:10,220 RESEARCH SPECIFICALLY. 3174 02:16:10,220 --> 02:16:13,723 REALLY IT'S BEEN A VERY EXCITING 3175 02:16:13,723 --> 02:16:15,692 FEW WEEKS ON THAT FRONT. 3176 02:16:15,692 --> 02:16:16,993 ON MARCH 18 I WAS DELIGHTED TO 3177 02:16:16,993 --> 02:16:26,303 BE IN THE ROOM WITH DR. CLAYTON, 3178 02:16:26,303 --> 02:16:28,905 DR. MAZUR AND I DIRECTORS WHEN 3179 02:16:28,905 --> 02:16:30,874 PRESIDENT BIDEN SIGNED AN ORDER 3180 02:16:30,874 --> 02:16:31,842 EXPANDING FEDERAL RESEARCH 3181 02:16:31,842 --> 02:16:32,542 CONCERNING WOMEN'S HEALTH, 3182 02:16:32,542 --> 02:16:33,944 FOLLOWING HIS STATE OF THE UNION 3183 02:16:33,944 --> 02:16:35,879 ADDRESS LAST MONTH WHERE HE LAID 3184 02:16:35,879 --> 02:16:38,114 OUT A VISION FOR TRANSFORMING 3185 02:16:38,114 --> 02:16:42,018 WOMEN'S HEALTH RESEARCH. 3186 02:16:42,018 --> 02:16:43,887 FOR FAR TOO LONG, ISSUES 3187 02:16:43,887 --> 02:16:49,693 SPECIFIC TO WOMEN HAVE GONE 3188 02:16:49,693 --> 02:16:49,993 UNADDRESSED. 3189 02:16:49,993 --> 02:16:51,528 EVEN THOUGH NIH REQUIRES AND HAS 3190 02:16:51,528 --> 02:16:54,631 FOR QUITE A LONG TIME THAT WOMEN 3191 02:16:54,631 --> 02:16:57,033 AND RACIAL AND ETHNIC MINORITY 3192 02:16:57,033 --> 02:16:59,002 GROUPS MUST BE REPRESENTED IN 3193 02:16:59,002 --> 02:17:00,971 CLINICAL RESEARCH, WE STILL HAVE 3194 02:17:00,971 --> 02:17:02,906 IMPORTANT GAPS REMAINING. 3195 02:17:02,906 --> 02:17:04,908 A PARTICULAR AREA OF CONCERN HAS 3196 02:17:04,908 --> 02:17:07,310 BEEN THE LACK OF STUDY OF 3197 02:17:07,310 --> 02:17:09,279 MID-LIFE CONDITIONS SUCH AS 3198 02:17:09,279 --> 02:17:11,047 MENOPAUSE, THE UNIQUE WAYS HEART 3199 02:17:11,047 --> 02:17:14,651 DISEASE AFFECTS WOMEN AND 3200 02:17:14,651 --> 02:17:16,086 AUTOIMMUNE DISEASES, CONDITIONS 3201 02:17:16,086 --> 02:17:16,953 THAT DISPROPORTIONATELY AFFECT 3202 02:17:16,953 --> 02:17:17,387 WOMEN. 3203 02:17:17,387 --> 02:17:18,688 THE WHITE HOUSE INITIATIVE ON 3204 02:17:18,688 --> 02:17:20,891 WOMEN'S HEALTH RESEARCH HAS THE 3205 02:17:20,891 --> 02:17:22,626 GOAL OF FUNDAMENTALLY CHANGING 3206 02:17:22,626 --> 02:17:24,394 HOW WE APPROACH AND FUND WOMEN'S 3207 02:17:24,394 --> 02:17:27,230 HEALTH RESEARCH IN THE UNITED 3208 02:17:27,230 --> 02:17:27,797 STATES. 3209 02:17:27,797 --> 02:17:28,765 NEXT SLIDE. 3210 02:17:28,765 --> 02:17:30,000 THE EXECUTIVE ORDER PRESIDENT 3211 02:17:30,000 --> 02:17:32,469 BIDEN SIGNED ON MARCH 18 DIRECTS 3212 02:17:32,469 --> 02:17:35,105 THE MOST COMPREHENSIVE SET OF 3213 02:17:35,105 --> 02:17:36,873 EXECUTIVE ACTIONS EVER TAKEN TO 3214 02:17:36,873 --> 02:17:38,508 EXPAND AND IMPROVE RESEARCH ON 3215 02:17:38,508 --> 02:17:39,476 WOMEN'S HEALTH. 3216 02:17:39,476 --> 02:17:41,344 THESE DIRECTIVES WILL MAKE SURE 3217 02:17:41,344 --> 02:17:44,080 WOMEN'S HEALTH RESEARCH IS 3218 02:17:44,080 --> 02:17:45,148 INTEGRATED AND PRIORITIZED 3219 02:17:45,148 --> 02:17:46,950 ACROSS THE ENTIRE FEDERAL 3220 02:17:46,950 --> 02:17:47,984 GOVERNMENT, INCLUDING THE 3221 02:17:47,984 --> 02:17:50,420 DEPARTMENT OF DEFENSE, V.A., 3222 02:17:50,420 --> 02:17:52,289 NATIONAL SCIENCE FOUNDATION, AS 3223 02:17:52,289 --> 02:17:56,559 WELL AS THE MANY DEPARTMENTS -- 3224 02:17:56,559 --> 02:17:57,427 MANY AGENCIES OF THE DEPARTMENT 3225 02:17:57,427 --> 02:17:59,729 OF HEALTH AND HUMAN SERVICES. 3226 02:17:59,729 --> 02:18:01,798 THE EXECUTIVE ORDER ALSO 3227 02:18:01,798 --> 02:18:04,367 INITIATED A NEW NIH-WIDE EFFORT 3228 02:18:04,367 --> 02:18:08,271 TO INVEST $200 MILLION IN FISCAL 3229 02:18:08,271 --> 02:18:10,473 YEAR 2025, TO SUPPORT NEW 3230 02:18:10,473 --> 02:18:11,975 INTERDISCIPLINARY PROJECTS IN 3231 02:18:11,975 --> 02:18:13,109 WOMEN'S HEALTH RESEARCH. 3232 02:18:13,109 --> 02:18:15,345 AND THEN FINALLY IN HIS STATE OF 3233 02:18:15,345 --> 02:18:17,147 THE UNION ADDRESS PRESIDENT 3234 02:18:17,147 --> 02:18:20,650 BIDEN CALLS ON CONGRESS TO DO 3235 02:18:20,650 --> 02:18:22,519 EVEN MORE TO ALLOCATE $12 3236 02:18:22,519 --> 02:18:24,354 BILLION TO NIH SPECIFICALLY FOR 3237 02:18:24,354 --> 02:18:26,022 WOMEN'S HEALTH RESEARCH. 3238 02:18:26,022 --> 02:18:28,959 THIS WOULD BUILD ON THE NIH-WIDE 3239 02:18:28,959 --> 02:18:29,960 EFFORT ANNOUNCED IN THE 3240 02:18:29,960 --> 02:18:32,228 EXECUTIVE ORDER, AND ESTABLISH A 3241 02:18:32,228 --> 02:18:33,763 NATIONWIDE NETWORK OF RESEARCH 3242 02:18:33,763 --> 02:18:35,398 CENTERS OF EXCELLENCE AND 3243 02:18:35,398 --> 02:18:37,167 INNOVATION IN WOMEN'S HEALTH. 3244 02:18:37,167 --> 02:18:38,601 WHICH WOULD SERVE AS NATIONAL 3245 02:18:38,601 --> 02:18:40,804 GOLD STANDARD FOR WOMEN'S HEALTH 3246 02:18:40,804 --> 02:18:43,506 RESEARCH ACROSS THE LIFESPAN. 3247 02:18:43,506 --> 02:18:44,307 NEXT SLIDE. 3248 02:18:44,307 --> 02:18:47,544 WE'RE ALL AWARE OF THE NEED FOR 3249 02:18:47,544 --> 02:18:48,178 GREATER UNDERSTANDING OF WOMEN'S 3250 02:18:48,178 --> 02:18:51,815 HEALTH AND WE AT NIH HAVE MADE 3251 02:18:51,815 --> 02:18:53,583 AN ENTERPRISE-WIDE COMMITMENT TO 3252 02:18:53,583 --> 02:18:54,985 WOMEN'S HEALTH RESEARCH. 3253 02:18:54,985 --> 02:18:57,620 IN FACT, WOMEN'S HEALTH IS ONE 3254 02:18:57,620 --> 02:19:00,056 OF THE FIVE CROSS-CUTSING THEMES 3255 02:19:00,056 --> 02:19:01,124 WITHIN THE NIH WIDE STRATEGIC 3256 02:19:01,124 --> 02:19:02,225 PLAN FRAMEWORK THAT'S BEEN IN 3257 02:19:02,225 --> 02:19:03,760 PLACE FOR AT LEAST THE PAST 3258 02:19:03,760 --> 02:19:05,195 SEVERAL YEARS. 3259 02:19:05,195 --> 02:19:06,262 NEXT SLIDE. 3260 02:19:06,262 --> 02:19:08,031 WE NEED MORE RESEARCH THAT 3261 02:19:08,031 --> 02:19:09,766 ADDRESSES WOMEN'S HEALTH AND 3262 02:19:09,766 --> 02:19:11,735 WELL-BEING ACROSS THE ENTIRE 3263 02:19:11,735 --> 02:19:12,836 LIFESPAN. 3264 02:19:12,836 --> 02:19:14,571 WE NEED TO INCLUDE FOR INSTANCE 3265 02:19:14,571 --> 02:19:17,173 YOUNG WIN IN OUR PRIORITIES. 3266 02:19:17,173 --> 02:19:18,942 FOR EXAMPLE, ADOLESCENCE IS A 3267 02:19:18,942 --> 02:19:21,244 TIME OF MANY CHALLENGES, AND 3268 02:19:21,244 --> 02:19:23,146 THIS LIFE TRANSITION AFFECTS 3269 02:19:23,146 --> 02:19:26,416 BOYS AND GIRLS DIFFERENTLY. 3270 02:19:26,416 --> 02:19:28,485 FOR EXAMPLE, TEENAGE GIRLS HAVE 3271 02:19:28,485 --> 02:19:30,120 MORE CHALLENGE WITH BODY IMAGE 3272 02:19:30,120 --> 02:19:32,522 THAT COULD LEAD TO LIFELONG 3273 02:19:32,522 --> 02:19:35,158 ISSUES WITH SELF-ESTEEM AND 3274 02:19:35,158 --> 02:19:35,792 POTENTIALLY LIFE-THREATENING 3275 02:19:35,792 --> 02:19:36,793 DISORDERS, ANOREXIA, BULIMIA. 3276 02:19:36,793 --> 02:19:40,296 WE NEED TO MAKE MORE PROGRESS TO 3277 02:19:40,296 --> 02:19:42,866 ADDRESS PREVENTION OR TREATMENT 3278 02:19:42,866 --> 02:19:45,001 FOR THIS EXAMPLE OF A 3279 02:19:45,001 --> 02:19:47,070 SIGNIFICANT FACTOR IN WELL-BEING 3280 02:19:47,070 --> 02:19:48,271 OF COUNTLESS WOMEN. 3281 02:19:48,271 --> 02:19:51,241 MENTAL HEALTH IN GENERAL IS AN 3282 02:19:51,241 --> 02:19:53,643 IMPORTANT OFTEN LIFELONG ISSUE, 3283 02:19:53,643 --> 02:19:56,379 AND THE NEW EXECUTIVE ORDER WILL 3284 02:19:56,379 --> 02:19:57,914 SUPPORT HEALTHCARE PROVIDERS, 3285 02:19:57,914 --> 02:19:58,681 INCLUDING WITH THE NEEDED 3286 02:19:58,681 --> 02:20:00,750 TRAINING TO ADDRESS THE HEALTH 3287 02:20:00,750 --> 02:20:02,819 OF WOMEN AND CHILDREN AFFECTED 3288 02:20:02,819 --> 02:20:05,889 BY MENTAL HEALTH AND SUBSTANCE 3289 02:20:05,889 --> 02:20:06,990 USE DISORDERS. 3290 02:20:06,990 --> 02:20:08,258 A CROSS-CUTTING THEME AT ALL 3291 02:20:08,258 --> 02:20:11,227 AGES IS WE NEED TO BE MORE 3292 02:20:11,227 --> 02:20:12,529 COMFORTABLE TALKING ABOUT 3293 02:20:12,529 --> 02:20:13,763 CONDITIONS THAT AFFECT OUR 3294 02:20:13,763 --> 02:20:14,230 HEALTH. 3295 02:20:14,230 --> 02:20:15,965 WE WANT WOMEN TO BE MORE OPEN 3296 02:20:15,965 --> 02:20:17,367 ABOUT THEIR HEALTH AND 3297 02:20:17,367 --> 02:20:19,002 WELL-BEING SO THEY CAN RECEIVE 3298 02:20:19,002 --> 02:20:22,172 THE ATTENTION AND CARE THEY 3299 02:20:22,172 --> 02:20:22,372 NEED. 3300 02:20:22,372 --> 02:20:23,807 NEXT SLIDE. 3301 02:20:23,807 --> 02:20:26,009 IT IS DIFFICULT TO IMAGINE A 3302 02:20:26,009 --> 02:20:27,844 GREATER TRAGEDY THAN THE DEATH 3303 02:20:27,844 --> 02:20:30,046 OF A YOUNG MOTHER, YET WE'RE 3304 02:20:30,046 --> 02:20:32,582 SEEING A DISTURBING NUMBER OF 3305 02:20:32,582 --> 02:20:34,417 DEATHS IN THE POSTPARTUM PERIOD 3306 02:20:34,417 --> 02:20:37,520 WITH LEADING CAUSES RELATED TO 3307 02:20:37,520 --> 02:20:39,355 DEPRESSION, OR SUBSTANCE ABUSE. 3308 02:20:39,355 --> 02:20:40,657 OF COURSE, PREGNANCY ITSELF PUTS 3309 02:20:40,657 --> 02:20:42,659 AN ENORMOUS STRAIN ON THE BODY 3310 02:20:42,659 --> 02:20:44,828 AND RATES OF HYPERTENSION DURING 3311 02:20:44,828 --> 02:20:45,495 PREGNANCY ARE INCREASING. 3312 02:20:45,495 --> 02:20:49,432 AND CAN BE VERY DANGEROUS. 3313 02:20:49,432 --> 02:20:52,602 RISKS OF MATERNAL MORBIDITY AND 3314 02:20:52,602 --> 02:20:59,209 TORE MORTAL VARIES ACROSS 3315 02:20:59,209 --> 02:21:00,276 GROUPS. 3316 02:21:00,276 --> 02:21:01,711 MATERNAL DEATH RATES ARE 2.5 3317 02:21:01,711 --> 02:21:03,246 TIMES HIGHER FOR BLACK WOMEN 3318 02:21:03,246 --> 02:21:06,516 COMPARED TO WHITE WOMEN. 3319 02:21:06,516 --> 02:21:08,251 WE NEED NEW WAYS TO ENSURE WOMEN 3320 02:21:08,251 --> 02:21:11,654 SECH THE SUPPORT -- RECEIVE THE 3321 02:21:11,654 --> 02:21:13,490 SUPPORT THEY NEED DURING 3322 02:21:13,490 --> 02:21:14,491 PREGNANCY AND VULNERABLE TIME 3323 02:21:14,491 --> 02:21:16,993 AROUND THE BIRTH OF A CHILD. 3324 02:21:16,993 --> 02:21:19,195 THIS ISSUE OR COURSE AFFECTS 3325 02:21:19,195 --> 02:21:20,830 WOMEN WORLDWIDE, NIH RESEARCH 3326 02:21:20,830 --> 02:21:24,000 HAS AN IMPORTANT ROLE BEYOND OUR 3327 02:21:24,000 --> 02:21:25,301 OWN BORDERS. 3328 02:21:25,301 --> 02:21:27,303 RECENT RESEARCH SUGGESTS THAT, 3329 02:21:27,303 --> 02:21:30,140 FOR EXAMPLE, RELATIVELY 3330 02:21:30,140 --> 02:21:32,242 STRAIGHTFORWARD INTERVENTIONS TO 3331 02:21:32,242 --> 02:21:35,078 REDUCE POSTPARTUM ANXIETY AND 3332 02:21:35,078 --> 02:21:37,347 DEPRESSION CAN BE EFFECTIVE. 3333 02:21:37,347 --> 02:21:39,649 AN ARTICLE IN NATURE MEDICINE 3334 02:21:39,649 --> 02:21:43,253 LAST MONTH DESCRIBED A LARGE 3335 02:21:43,253 --> 02:21:52,128 NIH-SUPPORTED CLINICAL TRIAL IN 3336 02:21:52,128 --> 02:21:52,996 PAKISTAN, WITH AN INTERVENTION 3337 02:21:52,996 --> 02:21:54,397 IN WOMEN WITH SYMPTOMS OF 3338 02:21:54,397 --> 02:21:57,033 ANXIETY THAT REDUCE THE LEVELS 3339 02:21:57,033 --> 02:21:58,801 OF ANXIETY AND REDUCED THEIR 3340 02:21:58,801 --> 02:22:01,304 DEPRESSION SIX WEEKS AFTER 3341 02:22:01,304 --> 02:22:05,241 CHILDBIRTH BY TWO-THIRDS OR 3342 02:22:05,241 --> 02:22:05,441 MORE. 3343 02:22:05,441 --> 02:22:06,442 THIS KEY STRAIGHTFORWARD STEP 3344 02:22:06,442 --> 02:22:10,647 WILL NOT ONLY HELP US IDENTIFY 3345 02:22:10,647 --> 02:22:11,915 INTERVENTIONS THAT WORK BUT ALSO 3346 02:22:11,915 --> 02:22:13,683 DOES MUCH TO ALLOW US TO 3347 02:22:13,683 --> 02:22:15,552 DETERMINE HOW TO DELIVER 3348 02:22:15,552 --> 02:22:17,187 EFFECTIVE TREATMENT TO PEOPLE 3349 02:22:17,187 --> 02:22:20,924 WHO NEED THEM. 3350 02:22:20,924 --> 02:22:21,991 NEXT SLIDE. 3351 02:22:21,991 --> 02:22:29,999 I DEEPLY APPRECIATE FROM MY 3352 02:22:29,999 --> 02:22:31,000 RURAL UPBRINGING HEALTH CARE, 3353 02:22:31,000 --> 02:22:33,169 MATERNAL DESERTS IN RED, LOW 3354 02:22:33,169 --> 02:22:36,472 ACCESS TO MATERNITY CARE IN 3355 02:22:36,472 --> 02:22:37,140 ORANGE. 3356 02:22:37,140 --> 02:22:39,742 OF COURSE, RURAL AREAS ALSO LACK 3357 02:22:39,742 --> 02:22:40,944 ACCESS TO QUALITY MEDICAL CARE 3358 02:22:40,944 --> 02:22:43,246 BUT SO DO PEOPLE IN MORE DENSELY 3359 02:22:43,246 --> 02:22:45,014 POPULATED AREAS BECAUSE OF 3360 02:22:45,014 --> 02:22:46,549 POVERTY AND OTHER CONSTRAINTS 3361 02:22:46,549 --> 02:22:48,952 LIKE LACK OF ACCESS TO 3362 02:22:48,952 --> 02:22:53,122 TRANSPORTATION OR CHILD CARE. 3363 02:22:53,122 --> 02:22:56,492 BECAUSE OF THE COMPLEXITY OR 3364 02:22:56,492 --> 02:22:58,027 RACISM IN THE SYSTEM SUPPOSED TO 3365 02:22:58,027 --> 02:23:01,431 BE CARING FOR THEM. 3366 02:23:01,431 --> 02:23:02,999 NIH LAUNCHED THE "IMPROVE" 3367 02:23:02,999 --> 02:23:04,200 INITIATIVE IN 2019 IN RESPONSE 3368 02:23:04,200 --> 02:23:07,370 TO HIGH RATES OF 3369 02:23:07,370 --> 02:23:08,137 PREGNANCY-RELATED COMPLICATIONS 3370 02:23:08,137 --> 02:23:10,173 AND DEATHS IN OUR COUNTRY. 3371 02:23:10,173 --> 02:23:14,077 THIS INITIATIVE SUPPORTS 3372 02:23:14,077 --> 02:23:15,578 RESEARCH TO REDUCE PREVENTABLE 3373 02:23:15,578 --> 02:23:17,547 CAUSES AND IMPROVE HEALTH FOR 3374 02:23:17,547 --> 02:23:22,352 WOMEN BEFORE, DURING, AFTER 3375 02:23:22,352 --> 02:23:22,619 PREGNANCY. 3376 02:23:22,619 --> 02:23:24,887 IT INCLUDES EMPHASIS ON HEALTH 3377 02:23:24,887 --> 02:23:26,656 DISPARITIES IN POPULATIONS 3378 02:23:26,656 --> 02:23:37,166 DISPROPORTIONATELY AFFECTED. 3379 02:23:38,001 --> 02:23:45,842 LAST AUGUST IMPROV ESTABLISHED 3380 02:23:45,842 --> 02:23:48,344 TEN INITIATIVES TO ADDRESS 3381 02:23:48,344 --> 02:23:52,615 FACTORS THAT CAN LEAD TO OR HELP 3382 02:23:52,615 --> 02:23:53,516 PREVENT PREGNANCY-RELATED 3383 02:23:53,516 --> 02:23:56,119 COMPLICATIONS AND DEATH. 3384 02:23:56,119 --> 02:23:58,087 NEXT SLIDE. 3385 02:23:58,087 --> 02:24:01,824 EXAMPLE OF IMPROVED PROGRAM IS 3386 02:24:01,824 --> 02:24:02,825 IMPROV COMMUNITY IMPLEMENTATION 3387 02:24:02,825 --> 02:24:03,993 PROGRAM SUPPORTING RESEARCH TO 3388 02:24:03,993 --> 02:24:05,762 ADDRESS THE FACTORS THAT 3389 02:24:05,762 --> 02:24:07,830 CONTRIBUTE TO MATERNAL MORBIDITY 3390 02:24:07,830 --> 02:24:09,032 AND MORTALITY. 3391 02:24:09,032 --> 02:24:12,635 SUCH AS MENTAL HEALTH, SUBSTANCE 3392 02:24:12,635 --> 02:24:14,404 ABUSE, PSYCHOSOCIAL FACTORS, AND 3393 02:24:14,404 --> 02:24:18,374 SOCIAL AND STRUCTURAL 3394 02:24:18,374 --> 02:24:21,644 DETERMINANTS OF HEALTH. 3395 02:24:21,644 --> 02:24:24,480 AN EXAMPLE IS BEING CONDUCTED AT 3396 02:24:24,480 --> 02:24:26,349 THE UNIVERSITY OF NEBRASKA WITH 3397 02:24:26,349 --> 02:24:28,951 THE WINNEBAGO TRIBE. 3398 02:24:28,951 --> 02:24:30,920 THE NIH COMMUNITY ENGAGEMENT 3399 02:24:30,920 --> 02:24:34,324 ALLIANCE, CEAL, BEGAN AS AN 3400 02:24:34,324 --> 02:24:35,258 EFFORT AGAINST COVID-19 3401 02:24:35,258 --> 02:24:36,959 DISPARITIES BUT HAS BEEN SO 3402 02:24:36,959 --> 02:24:39,128 PROMISING THAT IT WAS EXPANDED 3403 02:24:39,128 --> 02:24:42,432 TO ADDRESS OTHER AREAS OF HEALTH 3404 02:24:42,432 --> 02:24:44,167 DISPARITIES, INCLUDING MATERNITY 3405 02:24:44,167 --> 02:24:45,702 HEALTH, HEALTH KNOWLEDGE, 3406 02:24:45,702 --> 02:24:47,603 PRIMARY CARE RESEARCH. 3407 02:24:47,603 --> 02:24:48,905 CEAL'S PRIMARY CARE RESEARCH 3408 02:24:48,905 --> 02:24:50,873 NETWORK IS AN IMPORTANT STEP 3409 02:24:50,873 --> 02:24:53,943 TOWARD OUR GOAL OF DEVELOPING A 3410 02:24:53,943 --> 02:24:55,712 NATIONWIDE PRIMARY CARE NETWORK 3411 02:24:55,712 --> 02:25:00,083 THAT HELPS US GATHER DATA TO 3412 02:25:00,083 --> 02:25:05,888 DRIVE EVIDENCE-DRIVEN HEALTH 3413 02:25:05,888 --> 02:25:06,589 CARE. 3414 02:25:06,589 --> 02:25:07,290 CEAL'S CARE-NET INCLUDES 3415 02:25:07,290 --> 02:25:11,361 PARTICIPANTS IN 40 STATES AND 3416 02:25:11,361 --> 02:25:12,128 TERRITORIES. 3417 02:25:12,128 --> 02:25:13,096 NEXT SLIDE. 3418 02:25:13,096 --> 02:25:14,497 RESEARCH SUPPORTED BY THE 3419 02:25:14,497 --> 02:25:16,265 NATIONAL HEART, LUNG AND BLOOD 3420 02:25:16,265 --> 02:25:18,368 INSTITUTE HAS FOUND A DISTURBING 3421 02:25:18,368 --> 02:25:21,504 INCREASE IN RATES OF CHRONIC 3422 02:25:21,504 --> 02:25:22,405 HYPERTENSION IN PREGNANCY FOR 3423 02:25:22,405 --> 02:25:24,374 AMERICAN WOMEN OVER TIME. 3424 02:25:24,374 --> 02:25:26,709 WITH EFFECT MORE PRONOUNCED IN 3425 02:25:26,709 --> 02:25:28,745 RURAL POPULATIONS THAN URBAN. 3426 02:25:28,745 --> 02:25:30,847 IN BLACK AND HISPANIC WOMEN MORE 3427 02:25:30,847 --> 02:25:34,984 THAN IN WHITE WOMEN. 3428 02:25:34,984 --> 02:25:41,190 THIS RISE ISN'T ENTIRELY DUE TO 3429 02:25:41,190 --> 02:25:42,325 AGE, THE TRIAL SHOWED TREATING 3430 02:25:42,325 --> 02:25:44,160 THIS CONDITION EARLY IN 3431 02:25:44,160 --> 02:25:44,727 PREGNANCY REDUCES ADVERSE 3432 02:25:44,727 --> 02:25:46,796 OUTCOMES AS SEEN IN THE GRAPH ON 3433 02:25:46,796 --> 02:25:47,563 THE RIGHT. 3434 02:25:47,563 --> 02:25:50,133 BASED ON THESE FINDINGS, THE 3435 02:25:50,133 --> 02:25:52,468 AMERICAN COLLEGE OF OBSTETRICS 3436 02:25:52,468 --> 02:25:56,105 AND GYNECOLOGY CHANGED GUIDANCE 3437 02:25:56,105 --> 02:25:57,740 FOR TREATING CHRONIC 3438 02:25:57,740 --> 02:25:59,842 HYPERTENSION DURING PREGNANCY. 3439 02:25:59,842 --> 02:26:00,276 NEXT SLIDE. 3440 02:26:00,276 --> 02:26:02,578 ONE OF THE AREAS OF FOCUS, THE 3441 02:26:02,578 --> 02:26:04,113 WHITE HOUSE INITIATIVE ON 3442 02:26:04,113 --> 02:26:06,516 WOMEN'S HEALTH IS MID-LIFE AND 3443 02:26:06,516 --> 02:26:08,251 THE TRANSITION INTO OLDER AGE. 3444 02:26:08,251 --> 02:26:10,019 WE STILL HAVE MUCH TO LEARN 3445 02:26:10,019 --> 02:26:12,555 ABOUT THE INTERPLAY BETWEEN THE 3446 02:26:12,555 --> 02:26:14,557 HORMONAL CHANGES OF MENOPAUSE 3447 02:26:14,557 --> 02:26:16,359 AND HEALTHY AGING FOR INSTANCE. 3448 02:26:16,359 --> 02:26:18,561 THE WHITE HOUSE INITIATIVE WILL 3449 02:26:18,561 --> 02:26:19,662 SUPPORT NEW NIH-FUNDED RESEARCH 3450 02:26:19,662 --> 02:26:22,965 ON THE IMPACT OF HORMONAL 3451 02:26:22,965 --> 02:26:24,700 CHANGES IN PERIMENOPAUSE AND 3452 02:26:24,700 --> 02:26:27,537 MENOPAUSE ON HEART HEALTH, BRAIN 3453 02:26:27,537 --> 02:26:29,071 HEALTH, AND BONE HEALTH. 3454 02:26:29,071 --> 02:26:30,473 FOR MANY WOMEN, WE ALSO STILL 3455 02:26:30,473 --> 02:26:32,008 DON'T KNOW HOW TO HANDLE THE 3456 02:26:32,008 --> 02:26:33,342 SYMPTOMS OF MENOPAUSE. 3457 02:26:33,342 --> 02:26:35,411 NOT ONLY HOT FLASHES BUT ALSO 3458 02:26:35,411 --> 02:26:38,014 LOSS OF SLEEP, A SYMPTOM THAT 3459 02:26:38,014 --> 02:26:40,450 HAS A PROFOUND EFFECT ON HEALTH 3460 02:26:40,450 --> 02:26:42,285 AND WELL-BEING. 3461 02:26:42,285 --> 02:26:46,022 A RECENT NIH-FUNDED STUDY FOUND 3462 02:26:46,022 --> 02:26:47,757 CHRONIC SLEEP DEFICIENCY 3463 02:26:47,757 --> 02:26:49,091 INCREASES INSULIN RESISTANCE, IN 3464 02:26:49,091 --> 02:26:51,861 OTHERWISE HEALTHY WOMEN. 3465 02:26:51,861 --> 02:26:53,563 ESPECIALLY AFTER MENOPAUSE. 3466 02:26:53,563 --> 02:26:59,702 WOMEN AND DOCTORS ARE LEFT 3467 02:26:59,702 --> 02:27:03,206 WITHOUT A WAY TO NAVIGATE OR THE 3468 02:27:03,206 --> 02:27:03,873 LONG-TERM CONSEQUENCES OF 3469 02:27:03,873 --> 02:27:04,507 HORMONAL CHANGES. 3470 02:27:04,507 --> 02:27:05,842 WE MUST ADDRESS THIS. 3471 02:27:05,842 --> 02:27:08,578 NIH IS LAUNCHING AN INTERAGENCY 3472 02:27:08,578 --> 02:27:10,413 PROCESS TO PULL TOGETHER THE 3473 02:27:10,413 --> 02:27:13,149 CURRENT STATE OF EVIDENCE ON 3474 02:27:13,149 --> 02:27:14,917 MENOPAUSE-RELATED ISSUES, IN 3475 02:27:14,917 --> 02:27:16,686 ORDER TO IDENTIFY GAPS, IN 3476 02:27:16,686 --> 02:27:19,522 EXISTING RESEARCH AND DEVELOP 3477 02:27:19,522 --> 02:27:22,091 AND EVIDENCE BASED TO GUIDE THE 3478 02:27:22,091 --> 02:27:23,426 FIELD FORWARD. 3479 02:27:23,426 --> 02:27:26,662 OF COURSE, NIH HAS BEEN STUDYING 3480 02:27:26,662 --> 02:27:27,530 THE ISSUES OF MENOPAUSE FOR 3481 02:27:27,530 --> 02:27:28,631 QUITE A LONG TIME. 3482 02:27:28,631 --> 02:27:31,133 FOR EXAMPLE, THROUGH THE WOMEN'S 3483 02:27:31,133 --> 02:27:34,537 HEALTH INITIATIVE STUDY 3484 02:27:34,537 --> 02:27:35,972 SUPPORTED BY NHLBI, THE STUDY 3485 02:27:35,972 --> 02:27:38,241 MANY MIGHT NOT KNOW IS STILL 3486 02:27:38,241 --> 02:27:41,210 GOING AND STILL YIELDING 3487 02:27:41,210 --> 02:27:42,178 IMPORTANT RESULTS SUCH AS 2021 3488 02:27:42,178 --> 02:27:44,614 FINDING SHOWN ON THE RIGHT THAT 3489 02:27:44,614 --> 02:27:46,482 THOSE WHO HAVE HYPERTENSION 3490 02:27:46,482 --> 02:27:49,652 DURING PREGNANCY ARE MORE LIKELY 3491 02:27:49,652 --> 02:27:50,853 TO EXPERIENCE HEART FAILURE 3492 02:27:50,853 --> 02:27:52,154 AFTER MENOPAUSE. 3493 02:27:52,154 --> 02:27:52,822 NEXT SLIDE. 3494 02:27:52,822 --> 02:27:54,457 ANOTHER FINDING FROM THE WOMEN'S 3495 02:27:54,457 --> 02:27:56,092 HEALTH INITIATIVE IS THE 3496 02:27:56,092 --> 02:27:57,760 OBSERVATION THAT LIGHT PHYSICAL 3497 02:27:57,760 --> 02:27:58,961 ACTIVITY IS ASSOCIATED WITH 3498 02:27:58,961 --> 02:28:01,130 REDUCED RISK FOR HEART DISEASE. 3499 02:28:01,130 --> 02:28:04,100 THE OBSERVATION LED TO AN 3500 02:28:04,100 --> 02:28:05,935 ONGOING INTERVENTIONAL STUDY TO 3501 02:28:05,935 --> 02:28:07,904 ASSESS EFFECTS OF PRESCRIBING 3502 02:28:07,904 --> 02:28:09,138 PHYSICAL ACTIVITY IN A LARGE 3503 02:28:09,138 --> 02:28:11,974 COHORT OF OLDER WOMEN. 3504 02:28:11,974 --> 02:28:12,842 NEXT SLIDE. 3505 02:28:12,842 --> 02:28:15,478 BEFORE CLOSING I WANT TO TOUCH 3506 02:28:15,478 --> 02:28:18,314 ON A COUPLE RECENT ILLUSTRATIVE 3507 02:28:18,314 --> 02:28:20,616 EXAMPLES HOW RELATIVELY SMALL 3508 02:28:20,616 --> 02:28:21,717 SCALE NIH-FUNDED RESEARCH 3509 02:28:21,717 --> 02:28:26,522 STUDIES CAN ALSO HAVE IMPORTANT 3510 02:28:26,522 --> 02:28:29,058 IMPLICATIONS FOR HEALTH. 3511 02:28:29,058 --> 02:28:29,659 ENDOMETRIOSIS AFFECTS AN 3512 02:28:29,659 --> 02:28:32,762 ESTIMATE 1 IN 10 U.S. WOMEN, AND 3513 02:28:32,762 --> 02:28:34,964 CAUSING SEVERE PAIN AND 3514 02:28:34,964 --> 02:28:35,498 INFERTILITY. 3515 02:28:35,498 --> 02:28:36,933 MANY WOMEN ENDURE YEARS OF 3516 02:28:36,933 --> 02:28:39,635 SYMPTOMS BEFORE RECEIVING A 3517 02:28:39,635 --> 02:28:41,737 DIAGNOSIS, WHICH SOMETIMES IS 3518 02:28:41,737 --> 02:28:44,140 ONLY CONFIRMED DURING SURGERY. 3519 02:28:44,140 --> 02:28:45,541 AVAILABLE TREATMENTS RANGING 3520 02:28:45,541 --> 02:28:47,843 FROM HORMONES TO HYSTERECTOMY 3521 02:28:47,843 --> 02:28:49,278 ARE NOT EFFECTIVE FOR EVERYONE. 3522 02:28:49,278 --> 02:28:50,913 SOME TREATMENT OPTIONS HAVE A 3523 02:28:50,913 --> 02:28:53,349 CHANCE FOR RECURRENCE AND MANY 3524 02:28:53,349 --> 02:28:55,451 HAVE CHALLENGING SIDE EFFECTS. 3525 02:28:55,451 --> 02:28:58,821 LAST MONTH AN NIH-FUNDED STUDY 3526 02:28:58,821 --> 02:29:05,695 ANNOUNCED THAT A NONSTEROIDAL 3527 02:29:05,695 --> 02:29:06,195 ANTI-INFLAMMATORY DRUG 3528 02:29:06,195 --> 02:29:08,364 FENOPROFEN NOT COMMONLY USED 3529 02:29:08,364 --> 02:29:09,765 COULD POTENTIALLY BE REPURPOSED 3530 02:29:09,765 --> 02:29:13,603 TO ALLEVIATE PAIN AND 3531 02:29:13,603 --> 02:29:16,539 INFLAMMATION IN ENDOMETRIOSIS 3532 02:29:16,539 --> 02:29:16,872 SPECIFICALLY. 3533 02:29:16,872 --> 02:29:17,540 RESEARCHERS AT THE UNIVERSITY OF 3534 02:29:17,540 --> 02:29:19,308 CALIFORNIA, SAN FRANCISCO CHOSE 3535 02:29:19,308 --> 02:29:21,611 THIS PARTICULAR DRUG TO TEST 3536 02:29:21,611 --> 02:29:25,881 USING COMPUTER ALGORITHM THAT 3537 02:29:25,881 --> 02:29:27,083 EVALUATED NEARLY 1300 EXISTING 3538 02:29:27,083 --> 02:29:30,252 COMPOUNDS FOR THEIR ABILITY TO 3539 02:29:30,252 --> 02:29:32,755 REVERSE GENE EXPRESSION PROFILES 3540 02:29:32,755 --> 02:29:34,857 RELATED TO ENDOMETRIOSIS AND ITS 3541 02:29:34,857 --> 02:29:35,291 GROWTH. 3542 02:29:35,291 --> 02:29:37,793 THE RESEARCHERS USED PUBLICLY 3543 02:29:37,793 --> 02:29:40,329 AVAILABLE DATA FROM PEOPLE WITH 3544 02:29:40,329 --> 02:29:44,533 ENDOMETRIOSIS TO SELECT 3545 02:29:44,533 --> 02:29:45,568 CANDIDATE COMPOUNDS. 3546 02:29:45,568 --> 02:29:46,102 FENOPROFEN LOOKS PROMISING 3547 02:29:46,102 --> 02:29:49,839 BECAUSE IT RETURNED THE HIGHES 3548 02:29:49,839 --> 02:29:50,606 GENE EXPRESSION REVERSAL SCORE 3549 02:29:50,606 --> 02:29:52,341 AND BELONGS TO A CLASS OF DRUGS 3550 02:29:52,341 --> 02:29:55,311 ONE OF THE FIRST LINE TREATMENTS 3551 02:29:55,311 --> 02:29:57,279 FOR THIS DISEASE. 3552 02:29:57,279 --> 02:29:59,882 THE EXISTING MEDICAL TREATMENTS 3553 02:29:59,882 --> 02:30:01,450 FOR ENDOMETRIOSIS PAIN ARE 3554 02:30:01,450 --> 02:30:02,184 UNFORTUNATELY INEFFECTIVE WHICH 3555 02:30:02,184 --> 02:30:05,154 LED TO A SEARCH FOR A BETTER 3556 02:30:05,154 --> 02:30:05,921 OPTION, AND FENOPROFEN 3557 02:30:05,921 --> 02:30:10,760 ADMINISTERED TO A RAT MODEL FOR 3558 02:30:10,760 --> 02:30:12,862 ENDOMETRIOSIS SUCCESSFULLY 3559 02:30:12,862 --> 02:30:19,335 ALLEVIATED A MARKER FOR 3560 02:30:19,335 --> 02:30:20,102 ENDOMETRIOSIS PAIN AND NEED TO 3561 02:30:20,102 --> 02:30:21,404 BE CONFIRMED IN PEOPLE. 3562 02:30:21,404 --> 02:30:25,908 I LIKE HOW IT SHOWS HOW 3563 02:30:25,908 --> 02:30:28,411 MOLECULAR ANALYSES, OPEN 3564 02:30:28,411 --> 02:30:29,512 DATABASES, AND LABORATORY 3565 02:30:29,512 --> 02:30:31,614 RESEARCH CAN YIELD TOGETHER 3566 02:30:31,614 --> 02:30:36,752 IMPORTANT CLUES ABOUT HOW TO 3567 02:30:36,752 --> 02:30:39,622 APPROACH STUBBORN PROBLEMS IN 3568 02:30:39,622 --> 02:30:44,160 WOMEN'S HEALTH CARE. 3569 02:30:44,160 --> 02:30:46,495 NIH SUPPORTS DOZENS OF PROGRAMS 3570 02:30:46,495 --> 02:30:49,265 TO PREVENT, DIAGNOSE, AND TREAT 3571 02:30:49,265 --> 02:30:50,132 ENDOMETRIOSIS. 3572 02:30:50,132 --> 02:30:51,534 NEXT, LAST BUT NOT LEAST, A FEW 3573 02:30:51,534 --> 02:30:54,837 WEEKS AGO IN MY NIH DIRECTOR'S 3574 02:30:54,837 --> 02:30:57,873 BLOG I TALKED ABOUT FASCINATING 3575 02:30:57,873 --> 02:30:58,974 FINDINGS FROM BASIC RESEARCH 3576 02:30:58,974 --> 02:31:01,811 THAT SEEM TO HAVE UNCOVERED 3577 02:31:01,811 --> 02:31:04,447 FINALLY A CLUE ABOUT WHY MOST 3578 02:31:04,447 --> 02:31:06,449 PEOPLE WITH AUTOIMMUNE DISEASES 3579 02:31:06,449 --> 02:31:08,050 ARE WOMEN. 3580 02:31:08,050 --> 02:31:10,686 AUTOIMMUNE DISEASES MAKE UP A 3581 02:31:10,686 --> 02:31:13,089 THIRD MOST PREVALENT CATEGORY OF 3582 02:31:13,089 --> 02:31:14,290 DISEASE AMONG WOMEN SURPASSED 3583 02:31:14,290 --> 02:31:16,292 ONLY BY CANCER AND HEART 3584 02:31:16,292 --> 02:31:16,826 DISEASE. 3585 02:31:16,826 --> 02:31:19,462 AS MANY AS FOUR OUT OF EVERY 3586 02:31:19,462 --> 02:31:22,832 FIVE PEOPLE WITH AN AUTOIMMUNE 3587 02:31:22,832 --> 02:31:23,499 CONDITION ARE WOMEN. 3588 02:31:23,499 --> 02:31:25,801 RECENT STUDY FOUND THIS COULD BE 3589 02:31:25,801 --> 02:31:29,638 DUE AT LEAST IN PART TO THE 3590 02:31:29,638 --> 02:31:32,041 BASIC FACT FEMALES HAVE TWO X 3591 02:31:32,041 --> 02:31:32,374 CHROMOSOMES. 3592 02:31:32,374 --> 02:31:34,910 MALES HAVE AN X AND Y. 3593 02:31:34,910 --> 02:31:36,445 SPECIFICALLY, IT HAS TO DO WITH 3594 02:31:36,445 --> 02:31:40,716 THE EXISTENCE OF A MOLECULE 3595 02:31:40,716 --> 02:31:43,085 CALLED EXIST THAT HELPS 3596 02:31:43,085 --> 02:31:46,188 INACTIVATE ONE OF THE TWO X 3597 02:31:46,188 --> 02:31:47,389 CHROMOSOMES IN FEMALES, 3598 02:31:47,389 --> 02:31:50,559 NECESSARY TO PREVENT CELLS FROM 3599 02:31:50,559 --> 02:31:53,529 PRODUCING TOO MANY PROTEINS 3600 02:31:53,529 --> 02:31:55,164 ENCODED ON X CHROMOSOMES TO 3601 02:31:55,164 --> 02:31:57,166 CORRECT GENE DOSING DIFFERENCE 3602 02:31:57,166 --> 02:31:59,769 BETWEEN MALES AND FEMALES. 3603 02:31:59,769 --> 02:32:01,737 BUT THESE MOLECULES CAN ALSO 3604 02:32:01,737 --> 02:32:03,606 ENCOURAGE FORMATION OF ODD 3605 02:32:03,606 --> 02:32:12,114 CLUMPS OF RNA, DNA, AND OTHER 3606 02:32:12,114 --> 02:32:15,184 PROTEINS THAT CAN TRIGGER STRONG 3607 02:32:15,184 --> 02:32:15,451 RESPONSES. 3608 02:32:15,451 --> 02:32:20,790 IF THEY ACTIVATE XIST IN MALE 3609 02:32:20,790 --> 02:32:25,261 MICE PRONE TO AUTOIMMUNE THEY 3610 02:32:25,261 --> 02:32:28,664 BECAME MORE SUSCEPTIBLE TO 3611 02:32:28,664 --> 02:32:31,734 DEVELOPING A LUPUS-LIKE 3612 02:32:31,734 --> 02:32:35,004 CONDITION, FOR EARLY TREATMENT 3613 02:32:35,004 --> 02:32:36,772 AND PREVENTION OF AUTOIMMUNE 3614 02:32:36,772 --> 02:32:37,740 DISEASES. 3615 02:32:37,740 --> 02:32:39,809 IT IS CRUCIAL FOR NIH TO 3616 02:32:39,809 --> 02:32:40,910 CONTINUE COMMITMENT TO BASIC 3617 02:32:40,910 --> 02:32:43,879 RESEARCH WHICH CAN YIELD SO MANY 3618 02:32:43,879 --> 02:32:46,382 UNEXPECTED INSIGHTS. 3619 02:32:46,382 --> 02:32:48,150 SO, FINALLY, SO MUCH, NEXT 3620 02:32:48,150 --> 02:32:50,119 SLIDE, SO MUCH TO DO. 3621 02:32:50,119 --> 02:32:51,854 SO MANY POSSIBILITIES FOR MAKING 3622 02:32:51,854 --> 02:32:55,257 THE WORLD BETTER FOR ALL WOMEN 3623 02:32:55,257 --> 02:32:57,326 BY ENSURING THAT THEY LEAD LONG 3624 02:32:57,326 --> 02:32:58,527 AND HEALTHY LIVES. 3625 02:32:58,527 --> 02:33:00,863 WITH THAT I'LL CLOSE AND THANK 3626 02:33:00,863 --> 02:33:02,264 YOU SO MUCH FOR THE OPPORTUNITY 3627 02:33:02,264 --> 02:33:09,705 TO SPEAK WITH YOU TODAY. 3628 02:33:09,705 --> 02:33:11,140 >> THANK YOU SO MUCH, DR. 3629 02:33:11,140 --> 02:33:11,540 BERTAGNOLLI. 3630 02:33:11,540 --> 02:33:13,142 THE FLOOR IS OPEN FOR QUESTIONS 3631 02:33:13,142 --> 02:33:18,848 AND QUESTIONS IN -- FROM THE 3632 02:33:18,848 --> 02:33:19,481 ADVISORY COMMITTEE MEMBERS. 3633 02:33:19,481 --> 02:33:21,350 >> THANK YOU FOR A WONDERFUL 3634 02:33:21,350 --> 02:33:21,684 PRESENTATION. 3635 02:33:21,684 --> 02:33:22,551 I LEARNED A LOT. 3636 02:33:22,551 --> 02:33:24,720 ONE THING -- YOU MENTIONED 3637 02:33:24,720 --> 02:33:32,161 SUBSTANCE ABUSE BUT NEVER 3638 02:33:32,161 --> 02:33:34,697 EXPLICITLY MENTIONED CIGARETTE 3639 02:33:34,697 --> 02:33:36,098 SMOKING, WREAKING HAVOC ON THE 3640 02:33:36,098 --> 02:33:39,001 MANY DISPARITIES YOU MENTIONED 3641 02:33:39,001 --> 02:33:39,802 AND DISPROPORTIONATELY WOMEN, 3642 02:33:39,802 --> 02:33:40,102 RURAL WOMEN. 3643 02:33:40,102 --> 02:33:43,873 SO MUCH MORE WE CAN DO, JUST ONE 3644 02:33:43,873 --> 02:33:44,206 EXAMPLE. 3645 02:33:44,206 --> 02:33:46,508 MY OWN UNIVERSITY HOSPITAL WE DO 3646 02:33:46,508 --> 02:33:48,110 A GREAT JOB OF ASKING PEOPLE IF 3647 02:33:48,110 --> 02:33:50,346 THEY SMOKE WHEN THEY ARE 3648 02:33:50,346 --> 02:33:52,514 ADMITTED, BUT TERRIBLE JOB OF 3649 02:33:52,514 --> 02:33:55,050 DOING ANYTHING ABOUT IT, YET WE 3650 02:33:55,050 --> 02:33:58,220 KNOW ABOUT 50% OF THEM WILL DIE 3651 02:33:58,220 --> 02:34:00,856 OF SMOKING-RELATED ILLNESS IF WE 3652 02:34:00,856 --> 02:34:02,057 DON'T DO SOMETHING. 3653 02:34:02,057 --> 02:34:03,359 >> YEAH, WE HAVE INTERVENTIONS 3654 02:34:03,359 --> 02:34:04,894 THAT CAN HELP, RIGHT? 3655 02:34:04,894 --> 02:34:06,428 AND WORK. 3656 02:34:06,428 --> 02:34:08,063 AND YOU'VE JUST GIVEN YET 3657 02:34:08,063 --> 02:34:10,366 ANOTHER PITCH FOR OUR PRIMARY 3658 02:34:10,366 --> 02:34:12,568 CARE NETWORK AS A PLACE TO BE 3659 02:34:12,568 --> 02:34:15,170 ABLE TO GET TO THESE KINDS OF 3660 02:34:15,170 --> 02:34:15,571 QUESTIONS. 3661 02:34:15,571 --> 02:34:18,240 YOU KNOW, I DID WORK WITH NIH 3662 02:34:18,240 --> 02:34:20,743 FOR -- I MEAN NCI FOR MY WHOLE 3663 02:34:20,743 --> 02:34:22,811 CAREER AND THESE KINDS OF 3664 02:34:22,811 --> 02:34:23,812 PREVENTIONS WERE THE HARDEST FOR 3665 02:34:23,812 --> 02:34:27,683 US TO GET A HANDLE ON BECAUSE 3666 02:34:27,683 --> 02:34:32,688 OUR CLINICAL RESEARCH EFFORTS 3667 02:34:32,688 --> 02:34:35,758 WERE IN ONCOLOGIST OFFICE, NOT 3668 02:34:35,758 --> 02:34:39,261 THE PRIMARY DOCTOR, A SIMILAR 3669 02:34:39,261 --> 02:34:40,596 PROBLEM ACROSS MOST OF OUR 3670 02:34:40,596 --> 02:34:41,997 INSTITUTES AND CENTERS. 3671 02:34:41,997 --> 02:34:46,035 WE HOPE TO COMBAT THAT TO HAVE A 3672 02:34:46,035 --> 02:34:47,136 MECHANISM EVERYBODY CAN USE, YOU 3673 02:34:47,136 --> 02:34:51,507 JUST DESCRIBED A GREAT PLACE FOR 3674 02:34:51,507 --> 02:34:52,942 TESTING NEW INTERVENTION. 3675 02:34:52,942 --> 02:34:55,144 >> THANK YOU FOR AN 3676 02:34:55,144 --> 02:34:56,345 ALWAYS-INSPIRING TALK. 3677 02:34:56,345 --> 02:34:58,981 SO, I WAS STRUCK BY THE 3678 02:34:58,981 --> 02:35:00,616 INFORMATION THAT YOU PROVIDED 3679 02:35:00,616 --> 02:35:02,351 ABOUT THE NUMBER OF PATIENTS 3680 02:35:02,351 --> 02:35:06,855 THAT PROVIDED DATA IN BREAST 3681 02:35:06,855 --> 02:35:08,691 CANCER TRIALS, AND THE AMOUNT OF 3682 02:35:08,691 --> 02:35:10,359 FUNDING THAT WENT INTO THOSE 3683 02:35:10,359 --> 02:35:11,493 DISCOVERIES AND COMPELLED BY 3684 02:35:11,493 --> 02:35:13,062 YOUR STATEMENT THAT WE'RE NOT 3685 02:35:13,062 --> 02:35:14,096 DONE WITH THE DISCOVERIES 3686 02:35:14,096 --> 02:35:16,799 BECAUSE ONE THING THAT I HEAR 3687 02:35:16,799 --> 02:35:19,201 SOMETIMES AS A BREAST CANCER 3688 02:35:19,201 --> 02:35:20,102 SPECIALIST IS, YOU KNOW, 3689 02:35:20,102 --> 02:35:21,971 SHOULDN'T WE FOCUS ON ALL OF THE 3690 02:35:21,971 --> 02:35:26,008 OTHER DISEASES THAT WE KNOW SO 3691 02:35:26,008 --> 02:35:27,743 MUCH LESS ABOUT, AND PERSONALLY 3692 02:35:27,743 --> 02:35:29,745 AS A SOCIAL SCIENTIST, SOMEONE 3693 02:35:29,745 --> 02:35:31,680 CONCERNED ABOUT INEQUITIES, 3694 02:35:31,680 --> 02:35:33,115 THERE'S SO MANY IGNORED 3695 02:35:33,115 --> 02:35:35,417 POPULATIONS, WE HAVE NOT MADE 3696 02:35:35,417 --> 02:35:36,719 ENOUGH STRIDES IN METASTATIC 3697 02:35:36,719 --> 02:35:38,387 DISEASE, IN OLDER WOMEN, IN 3698 02:35:38,387 --> 02:35:39,521 RACIAL AND ETHNIC MINORITY 3699 02:35:39,521 --> 02:35:41,090 GROUPS, SO THERE ARE SO MANY 3700 02:35:41,090 --> 02:35:43,292 ADVANCES THAT WE NEED TO MAKE, 3701 02:35:43,292 --> 02:35:44,526 REALLY GLAD YOU GOT CUTTING EDGE 3702 02:35:44,526 --> 02:35:46,862 CARE I'M SURE BUT IT'S NOT 3703 02:35:46,862 --> 02:35:47,997 REACHING EVERYONE. 3704 02:35:47,997 --> 02:35:50,165 AND SO I THINK IT'S INCREDIBLY 3705 02:35:50,165 --> 02:35:52,267 IMPORTANT TO HAVE SOMEONE 3706 02:35:52,267 --> 02:35:54,236 LEADING NIH WHO EMPHASIZES THAT 3707 02:35:54,236 --> 02:35:55,871 WE'RE NOT DONE TILL IT REACHES 3708 02:35:55,871 --> 02:36:01,010 PATIENTS AND ALSO TO KEEP US 3709 02:36:01,010 --> 02:36:02,678 FROM PITTING PRIORITIES FOR 3710 02:36:02,678 --> 02:36:03,579 WOMEN'S HEALTH AGAINST ONE 3711 02:36:03,579 --> 02:36:04,079 ANOTHER. 3712 02:36:04,079 --> 02:36:06,048 THIS IS ABOUT NEEDING MORE 3713 02:36:06,048 --> 02:36:08,717 FUNDING FOR WOMEN'S HEALTH IN 3714 02:36:08,717 --> 02:36:09,151 GENERAL. 3715 02:36:09,151 --> 02:36:11,220 >> THANK YOU SO MUCH FOR SAYING 3716 02:36:11,220 --> 02:36:11,553 THAT. 3717 02:36:11,553 --> 02:36:14,523 YOU KNOW, EVERYONE'S GOT THEIR 3718 02:36:14,523 --> 02:36:17,559 FAVORITE PIECE OF THIS PUZZLE. 3719 02:36:17,559 --> 02:36:20,529 AT NIH WE HAVE TO -- WE'RE HERE 3720 02:36:20,529 --> 02:36:25,034 FOR EVERYBODY, FOR EVERYBODY. 3721 02:36:25,034 --> 02:36:27,302 AND I HAVE SOME THINGS OF HOPE 3722 02:36:27,302 --> 02:36:29,705 FOR THAT ARE. 3723 02:36:29,705 --> 02:36:31,673 FUNDAMENTAL SCIENCE REALLY IS 3724 02:36:31,673 --> 02:36:34,209 POWERFUL IN BEING ABLE TO 3725 02:36:34,209 --> 02:36:36,712 ADDRESS SO MANY THINGS 3726 02:36:36,712 --> 02:36:37,212 COMPREHENSIVELY. 3727 02:36:37,212 --> 02:36:40,749 SO THAT'S THE PLACE WHERE WE CAN 3728 02:36:40,749 --> 02:36:42,618 RAISE ALL THE FUNDAMENTAL 3729 02:36:42,618 --> 02:36:42,951 SCIENCE. 3730 02:36:42,951 --> 02:36:45,788 THE OTHER ONE IS HEALTH DELIVERY 3731 02:36:45,788 --> 02:36:46,055 RESEARCH. 3732 02:36:46,055 --> 02:36:48,323 YOU KNOW, IF WE CAN DELIVER 3733 02:36:48,323 --> 02:36:50,726 PROPER BREAST CANCER SCREENING 3734 02:36:50,726 --> 02:36:53,896 WE CAN DELIVER PROPER TREATMENT 3735 02:36:53,896 --> 02:36:54,663 FOR AUTOIMMUNE DISEASES. 3736 02:36:54,663 --> 02:36:56,398 YOU KNOW WHAT I MEAN? 3737 02:36:56,398 --> 02:36:58,133 SO THOSE TWO ENDS OF THE 3738 02:36:58,133 --> 02:37:00,235 SPECTRUM ARE THE GREAT LEVELERS, 3739 02:37:00,235 --> 02:37:03,005 IF YOU ASK ME, WHERE WE REALLY 3740 02:37:03,005 --> 02:37:04,106 CAN SERVE EVERYONE. 3741 02:37:04,106 --> 02:37:08,343 THEN IN THE MIDDLE, YES, EVERY 3742 02:37:08,343 --> 02:37:09,778 CONDITION IS DIFFERENT. 3743 02:37:09,778 --> 02:37:11,947 WE HAVE 27 INSTITUTES AND 3744 02:37:11,947 --> 02:37:13,715 CENTERS, THANK GOODNESS, BUZZ WE 3745 02:37:13,715 --> 02:37:15,684 CAN -- THE LAST THING I WANT TO 3746 02:37:15,684 --> 02:37:17,786 SAY IS THAT WE'RE WORKING 3747 02:37:17,786 --> 02:37:21,690 REALLY, REALLY HARD TO GET RID 3748 02:37:21,690 --> 02:37:22,891 OF OUR SILOS. 3749 02:37:22,891 --> 02:37:26,195 I'M SO THRILLED, I MEAN THE 3750 02:37:26,195 --> 02:37:28,163 RECEPTION AMONG THE DIRECTORS AT 3751 02:37:28,163 --> 02:37:29,798 NIH HAS BEEN TREMENDOUS FOR BOTH 3752 02:37:29,798 --> 02:37:33,068 OF THESE THINGS, GET RID OF OUR 3753 02:37:33,068 --> 02:37:34,837 SILOS SO THAT THOSE -- ANYONE 3754 02:37:34,837 --> 02:37:37,339 WHO FOCUSES ON ONE PIECE OF THE 3755 02:37:37,339 --> 02:37:38,140 PUZZLE CAN LEARN FROM WHAT'S 3756 02:37:38,140 --> 02:37:39,775 GOING ON ALL THE WAY AROUND 3757 02:37:39,775 --> 02:37:41,643 THEM. 3758 02:37:41,643 --> 02:37:45,681 THE EXAMPLE I'LL GIVE THERE IS 3759 02:37:45,681 --> 02:37:46,215 INFLAMMATION. 3760 02:37:46,215 --> 02:37:49,284 HOW MANY DISEASES HAVE 3761 02:37:49,284 --> 02:37:50,819 INFLAMMATION AT THEIR CORE? 3762 02:37:50,819 --> 02:37:52,688 EVEN RESPONSE TO CIGARETTES, 3763 02:37:52,688 --> 02:37:53,522 RIGHT? 3764 02:37:53,522 --> 02:37:55,958 HOW MANY DISEASES HAVE METABOLIC 3765 02:37:55,958 --> 02:37:58,160 SYNDROME AT THEIR CORE, HAVE 3766 02:37:58,160 --> 02:37:59,928 ABERRANT IMMUNE RESPONSE AT 3767 02:37:59,928 --> 02:38:01,096 THEIR CORE? 3768 02:38:01,096 --> 02:38:03,298 YOU KNOW, BUT HAVE WE BEEN AS 3769 02:38:03,298 --> 02:38:06,034 GOOD AS WE SHOULD AT TAKING ALL 3770 02:38:06,034 --> 02:38:07,569 THE DIFFERENT INSTITUTES AND 3771 02:38:07,569 --> 02:38:08,670 CENTERS AND RESEARCHERS THAT 3772 02:38:08,670 --> 02:38:09,771 HAVE BEEN STUDYING THOSE THINGS 3773 02:38:09,771 --> 02:38:11,073 AND BRINGING THEM TOGETHER? 3774 02:38:11,073 --> 02:38:13,575 THIS IS ALSO A REALLY BIG FOCUS 3775 02:38:13,575 --> 02:38:16,111 THAT WE'RE WORKING ON ACROSS ALL 3776 02:38:16,111 --> 02:38:17,980 OF NIH, WE'RE HOPING THAT -- 3777 02:38:17,980 --> 02:38:20,616 I'LL SHARE WITH YOU TODAY, WE'RE 3778 02:38:20,616 --> 02:38:21,617 HOPING TO MAKE THE NATIONAL 3779 02:38:21,617 --> 02:38:23,318 LIBRARY OF MEDICINE A REAL FOCAL 3780 02:38:23,318 --> 02:38:25,420 POINT FOR THIS KIND OF DATA 3781 02:38:25,420 --> 02:38:27,623 SHARING THAT WILL ALLOW US TO 3782 02:38:27,623 --> 02:38:31,527 BRING REALLY DIVERSE COMMUNITIES 3783 02:38:31,527 --> 02:38:33,295 TOGETHER. 3784 02:38:33,295 --> 02:38:37,766 >> THANK YOU VERY MUCH FOR THE 3785 02:38:37,766 --> 02:38:39,535 GREAT PRESENTATIONS. 3786 02:38:39,535 --> 02:38:40,736 AMBITIOUS GOALS. 3787 02:38:40,736 --> 02:38:42,137 ONCE THE ISSUES WITH 3788 02:38:42,137 --> 02:38:47,976 DISSEMINATION OF SCIENCE TO 3789 02:38:47,976 --> 02:38:48,911 COMMUNITIES, CONFIDENCE AND 3790 02:38:48,911 --> 02:38:51,346 SCIENCE OVERALL, TRUST IN 3791 02:38:51,346 --> 02:38:52,581 SCIENCE, A CRISIS EXACERBATED IN 3792 02:38:52,581 --> 02:38:53,482 RECENT YEARS, WHAT'S THE NIH 3793 02:38:53,482 --> 02:38:55,317 GOING TO DO ABOUT IT? 3794 02:38:55,317 --> 02:38:57,286 >> THIS IS A VERY, VERY, VERY 3795 02:38:57,286 --> 02:38:58,921 IMPORTANT QUESTION. 3796 02:38:58,921 --> 02:39:00,422 THERE'S TWO THINGS I THINK -- 3797 02:39:00,422 --> 02:39:02,958 WELL, FIRST OF ALL, THERE'S NO 3798 02:39:02,958 --> 02:39:05,494 WAY WE'RE GOING TO -- WE CAN'T 3799 02:39:05,494 --> 02:39:09,998 ASK FOR TRUST, WE CERTAINLY 3800 02:39:09,998 --> 02:39:11,099 CAN'T DEMAND TRUST. 3801 02:39:11,099 --> 02:39:13,268 WE HAVE TO EARN TRUST, BY ASKING 3802 02:39:13,268 --> 02:39:15,137 PEOPLE WHAT THEY NEED, AND THEN 3803 02:39:15,137 --> 02:39:17,639 MAKING IT HAPPEN FOR THEM. 3804 02:39:17,639 --> 02:39:19,841 NOT TELLING THEM WHAT THEY NEED. 3805 02:39:19,841 --> 02:39:21,810 ASKING THEM WHAT THEY NEED AND 3806 02:39:21,810 --> 02:39:23,345 THEN DELIVERING FOR THEM. 3807 02:39:23,345 --> 02:39:25,847 SO, HOW ARE WE DOING THAT? 3808 02:39:25,847 --> 02:39:28,050 ONE OF THE FEATURES OF THE 3809 02:39:28,050 --> 02:39:32,955 PRIMARY CARE NETWORK IS GOING TO 3810 02:39:32,955 --> 02:39:36,225 BE THE ABILITY TO ASK THE 3811 02:39:36,225 --> 02:39:38,093 PROVIDERS AND THE COMMUNITIES 3812 02:39:38,093 --> 02:39:40,429 WHAT QUESTIONS DO YOU WANT? 3813 02:39:40,429 --> 02:39:41,630 WHAT QUESTIONS CONCERN YOU? 3814 02:39:41,630 --> 02:39:42,931 WHAT ARE YOUR QUESTIONS? 3815 02:39:42,931 --> 02:39:46,435 WHAT CAN WE DO FOR YOU? 3816 02:39:46,435 --> 02:39:48,170 I'LL BET YOU ACROSS ALL THE 3817 02:39:48,170 --> 02:39:51,440 INSTITUTES AND CENTERS OF NIH WE 3818 02:39:51,440 --> 02:39:53,075 CAN FIND RESEARCH THAT'S GOING 3819 02:39:53,075 --> 02:39:54,509 TO ADDRESS THOSE QUESTIONS BUT 3820 02:39:54,509 --> 02:39:57,446 THEY ARE THE ONES ASKING FOR 3821 02:39:57,446 --> 02:39:59,414 THEM, NOT US PUSHING ON THEM. 3822 02:39:59,414 --> 02:40:00,649 SO OFFERING THEM A LOT OF CHOICE 3823 02:40:00,649 --> 02:40:02,184 IN WHAT THEY WANT TO PARTICIPATE 3824 02:40:02,184 --> 02:40:03,485 AND DO. 3825 02:40:03,485 --> 02:40:05,654 THE OTHER ONE IS I DO BELIEVE 3826 02:40:05,654 --> 02:40:08,056 PASSIONATELY IN DATA SHARING BUT 3827 02:40:08,056 --> 02:40:09,825 I ALSO BELIEVE THAT WE 3828 02:40:09,825 --> 02:40:10,792 SHOULDN'T -- THAT PEOPLE SHOULD 3829 02:40:10,792 --> 02:40:15,530 BE ABLE TO OPT IN. 3830 02:40:15,530 --> 02:40:19,434 WE'RE ALSO WORKING REALLY HARD 3831 02:40:19,434 --> 02:40:20,769 THROUGH THE OFFICE OF DATA 3832 02:40:20,769 --> 02:40:24,039 SCIENCE STRATEGY OF AN APPROACH 3833 02:40:24,039 --> 02:40:25,974 THAT WE HOPE ARE COLLABORATORS 3834 02:40:25,974 --> 02:40:26,775 WITH HEALTH AND HUMAN SERVICES 3835 02:40:26,775 --> 02:40:29,344 THAT WILL ALLOW US TO DIRECTLY 3836 02:40:29,344 --> 02:40:31,280 ASK PEOPLE, CAN WE USE YOUR 3837 02:40:31,280 --> 02:40:32,581 HEALTH DATA FOR RESEARCH? 3838 02:40:32,581 --> 02:40:34,216 IF THEY SAY NO, OF COURSE WE 3839 02:40:34,216 --> 02:40:35,317 WON'T. 3840 02:40:35,317 --> 02:40:37,085 IF THEY SAY YES, WE'VE ALREADY 3841 02:40:37,085 --> 02:40:38,920 BUILT TRUST. 3842 02:40:38,920 --> 02:40:40,022 CAN WE RECONTACT YOU IF 3843 02:40:40,022 --> 02:40:41,223 SOMETHING IS IMPORTANT FOR YOU? 3844 02:40:41,223 --> 02:40:43,191 I GUARANTEE YOU EVERYBODY WITH A 3845 02:40:43,191 --> 02:40:47,596 RARE DISEASE, EVERY PARENT WITH 3846 02:40:47,596 --> 02:40:48,964 A CHILD WITH MUSCULAR DYSTROPHY 3847 02:40:48,964 --> 02:40:50,632 OR AUTISM WILL SAY YES, PLEASE 3848 02:40:50,632 --> 02:40:51,099 CONTACT ME. 3849 02:40:51,099 --> 02:40:52,834 AND THEN WE HAVE A WAY OF 3850 02:40:52,834 --> 02:40:53,702 ACTUALLY ENGAGING. 3851 02:40:53,702 --> 02:40:55,804 THAT'S THE ONLY WAY WE EARN 3852 02:40:55,804 --> 02:40:56,004 TRUST. 3853 02:40:56,004 --> 02:41:00,275 WE'RE NEVER GOING TO DO IT WITH 3854 02:41:00,275 --> 02:41:01,810 PUBLIC RELATIONS CAMPAIGNS AND 3855 02:41:01,810 --> 02:41:04,980 SOUND BITES. 3856 02:41:04,980 --> 02:41:07,616 >> DR. SIMON AND DR. ANDERSON? 3857 02:41:07,616 --> 02:41:12,521 >> THANK YOU FOR THAT TALK. 3858 02:41:12,521 --> 02:41:12,754 AMAZING. 3859 02:41:12,754 --> 02:41:15,190 I'M FROM NORTHWESTERN, MELISSA 3860 02:41:15,190 --> 02:41:16,591 SIMON. 3861 02:41:16,591 --> 02:41:19,661 AS YOU DISPLAYED THAT MASS OF 3862 02:41:19,661 --> 02:41:20,762 MATERNITY DESERTS IS THERE AN 3863 02:41:20,762 --> 02:41:22,364 EFFORT AT NIH WITH RESPECT TO 3864 02:41:22,364 --> 02:41:24,032 THE TRAINING OF THE PIPELINE? 3865 02:41:24,032 --> 02:41:25,467 THERE'S ALSO WITH THOSE 3866 02:41:25,467 --> 02:41:27,536 MATERNITY DESERTS IN THOSE 3867 02:41:27,536 --> 02:41:30,372 AREAS, THOSE ARE ALSO OVERLAYING 3868 02:41:30,372 --> 02:41:33,775 WITH THE HIGHEST LEVELS OF 3869 02:41:33,775 --> 02:41:35,677 HIGHEST RATES OF MATERNAL 3870 02:41:35,677 --> 02:41:37,179 MORBIDITY AND MORTALITY, WITH 3871 02:41:37,179 --> 02:41:39,247 DESERTS OF HEALTHCARE PROVIDERS 3872 02:41:39,247 --> 02:41:40,949 AND RESEARCHERS THAT FOCUS ON 3873 02:41:40,949 --> 02:41:43,285 WOMEN'S HEALTH PROVISION AT THE 3874 02:41:43,285 --> 02:41:46,521 SAME TIME, AND THOSE AREAS OF 3875 02:41:46,521 --> 02:41:52,794 DESERTS TEND TO NOT HAVE THE NIH 3876 02:41:52,794 --> 02:41:56,298 FOCUSED PROGRAMS I GREW UP, AND 3877 02:41:56,298 --> 02:41:58,734 A SCHOLAR FROM NICHD A LONG TIME 3878 02:41:58,734 --> 02:42:02,237 AGO, ALL TEND TO MAP OUT. 3879 02:42:02,237 --> 02:42:04,873 THE BIRCWH IS DOING BETTER WITH 3880 02:42:04,873 --> 02:42:05,841 RECEPTIVE GEOGRAPHIC LOCATIONS 3881 02:42:05,841 --> 02:42:08,043 BUT IN TERMS OF TRAINING THE 3882 02:42:08,043 --> 02:42:09,778 PIPELINE THAT IS ACTUALLY GOING 3883 02:42:09,778 --> 02:42:12,748 TO COME FORTH WITH THIS 3884 02:42:12,748 --> 02:42:13,849 INNOVATIVE WOMEN'S HEALTH 3885 02:42:13,849 --> 02:42:14,816 RESEARCH, WHAT ARE WE DOING 3886 02:42:14,816 --> 02:42:15,250 THERE? 3887 02:42:15,250 --> 02:42:16,685 >> THERE ARE A NUMBER OF 3888 02:42:16,685 --> 02:42:19,388 PROGRAMS ACROSS NIH THAT HAVE 3889 02:42:19,388 --> 02:42:23,024 BEEN WORKING REALLY HARD TO 3890 02:42:23,024 --> 02:42:24,226 ENABLE RESEARCH IN AREAS THAT 3891 02:42:24,226 --> 02:42:28,063 HAVE BEEN LEFT OUT OF RESEARCH 3892 02:42:28,063 --> 02:42:28,363 PREVIOUSLY. 3893 02:42:28,363 --> 02:42:30,031 THERE ARE SOME -- THERE'S 3894 02:42:30,031 --> 02:42:33,001 SOMETHING CALLED THE IDEA CTN, 3895 02:42:33,001 --> 02:42:36,171 IDeA STATES, CLINICAL TRIALS 3896 02:42:36,171 --> 02:42:38,473 NETWORK, RESEARCH CAPACITY 3897 02:42:38,473 --> 02:42:40,242 BUILDING PROGRAMS THAT GET INTO 3898 02:42:40,242 --> 02:42:42,944 THOSE DESERTS ON THAT MAP. 3899 02:42:42,944 --> 02:42:45,280 THERE ARE -- CEAL, WHICH I 3900 02:42:45,280 --> 02:42:47,382 TALKED ABOUT, WHICH IS ALSO A 3901 02:42:47,382 --> 02:42:49,985 COLLABORATION ACROSS SEVERAL OF 3902 02:42:49,985 --> 02:42:52,154 THE DIFFERENT INSTITUTES. 3903 02:42:52,154 --> 02:42:56,158 THESE ARE TRAINING AND WORKFORCE 3904 02:42:56,158 --> 02:42:58,160 DEVELOPMENT AND CAPACITY 3905 02:42:58,160 --> 02:42:59,494 BUILDING PROGRAMS THAT ADDRESS 3906 02:42:59,494 --> 02:43:03,865 THOSE RED AND ORANGE AREAS ON 3907 02:43:03,865 --> 02:43:04,099 THE MAP. 3908 02:43:04,099 --> 02:43:05,300 NEXT, NOW THAT THERE'S BEEN A 3909 02:43:05,300 --> 02:43:07,135 LOT OF EFFORT GOING INTO 3910 02:43:07,135 --> 02:43:09,771 CAPACITY BUILDING, TO NOW PUT 3911 02:43:09,771 --> 02:43:12,641 THOSE AREAS TO WORK IN REAL -- 3912 02:43:12,641 --> 02:43:16,511 IN DELIVERING RESEARCH FOR THOSE 3913 02:43:16,511 --> 02:43:16,812 COMMUNITIES. 3914 02:43:16,812 --> 02:43:17,846 WE HAVEN'T CHOSEN EXACTLY WHICH 3915 02:43:17,846 --> 02:43:19,948 THE INITIAL SITES WILL BE FOR 3916 02:43:19,948 --> 02:43:21,383 THE PRIMARY CARE NETWORK, BUT 3917 02:43:21,383 --> 02:43:22,684 I'LL GIVE A HINT, THEY ARE GOING 3918 02:43:22,684 --> 02:43:24,553 TO BE IN THOSE LOCATIONS. 3919 02:43:24,553 --> 02:43:27,589 THOSE WILL BE WHERE WE START 3920 02:43:27,589 --> 02:43:27,923 FIRST. 3921 02:43:27,923 --> 02:43:32,761 THE FUNDING FOR NIH THIS YEAR 3922 02:43:32,761 --> 02:43:34,930 WAS MORE THAN WE EXPECTED 3923 02:43:34,930 --> 02:43:37,866 BECAUSE I THINK OUR 3924 02:43:37,866 --> 02:43:38,767 APPROPRIATORS WILL INCREDIBLY 3925 02:43:38,767 --> 02:43:39,534 GRATEFUL BECAUSE, YOU KNOW, WE 3926 02:43:39,534 --> 02:43:42,704 GET A LITTLE BIT OF A BUMP. 3927 02:43:42,704 --> 02:43:45,340 THEY STILL LEFT US IN A DEFICIT 3928 02:43:45,340 --> 02:43:46,775 FOR OUR PROGRAMS SO WE CAN'T 3929 02:43:46,775 --> 02:43:48,410 LAUNCH BIG WITH THIS PRIMARY 3930 02:43:48,410 --> 02:43:50,812 CARE NETWORK THIS YEAR BUT WE'RE 3931 02:43:50,812 --> 02:43:53,448 GOING TO LAUNCH FOCUSED AND 3932 02:43:53,448 --> 02:43:55,851 STRONG IN THOSE PARTICULAR 3933 02:43:55,851 --> 02:43:57,686 AREAS, WITH THE HOPE OF BEING 3934 02:43:57,686 --> 02:43:59,554 ABLE TO EXPAND IN THE NEAR 3935 02:43:59,554 --> 02:44:01,323 FUTURE TO COVER THOSE PARTS OF 3936 02:44:01,323 --> 02:44:03,058 THE COUNTRY THAT WE KNOW, WHERE 3937 02:44:03,058 --> 02:44:06,428 WE KNOW WE NEED TO BE. 3938 02:44:06,428 --> 02:44:07,496 >> WILL THOSE PRIMARY NETWORKS 3939 02:44:07,496 --> 02:44:10,065 INCLUDE OB/GYNs AS WELL? 3940 02:44:10,065 --> 02:44:14,769 >> PRIMARY CARE IS ANY -- THOSE 3941 02:44:14,769 --> 02:44:16,638 ARE PROVIDERS THAT SEE PATIENTS 3942 02:44:16,638 --> 02:44:20,775 NOT AS AN EPISODIC PROVIDER BUT 3943 02:44:20,775 --> 02:44:22,210 AS A CONTINUITY-BASED PROVIDER, 3944 02:44:22,210 --> 02:44:30,886 SO THEY WILL DEFINITELY INCLUDE 3945 02:44:30,886 --> 02:44:32,821 GYNECOLOGISTS, ANYONE PROVIDING 3946 02:44:32,821 --> 02:44:34,589 LONG-TERM CARE AND OBSTETRICIANS 3947 02:44:34,589 --> 02:44:37,425 TEND TO, YOU KNOW, YOU COULD 3948 02:44:37,425 --> 02:44:38,960 CALL THEM AT EPISODIC PROVIDER, 3949 02:44:38,960 --> 02:44:40,595 WE CALL THEM PART OF PRIMARY 3950 02:44:40,595 --> 02:44:41,363 CARE. 3951 02:44:41,363 --> 02:44:42,364 THAT'S A LITTLE FUDGE, IF YOU 3952 02:44:42,364 --> 02:44:44,566 TAKE THE DEFINITION OF PRIMARY 3953 02:44:44,566 --> 02:44:45,634 CARE SPECIFICALLY BUT WE VERY 3954 02:44:45,634 --> 02:44:47,402 MUCH INTEND TO INCLUDE PRIMARY 3955 02:44:47,402 --> 02:44:47,936 CARE. 3956 02:44:47,936 --> 02:44:48,136 WHY? 3957 02:44:48,136 --> 02:44:51,339 WE'VE GOT TO START ADDRESSING 3958 02:44:51,339 --> 02:44:52,741 THE CHALLENGES WITH 3959 02:44:52,741 --> 02:44:53,508 PREGNANCY-RELATED ADVERSE 3960 02:44:53,508 --> 02:44:53,742 EFFECTS. 3961 02:44:53,742 --> 02:44:55,377 THE OTHER ONE THAT'S NOT 3962 02:44:55,377 --> 02:44:56,378 TRADITIONALLY PART OF PRIMARY 3963 02:44:56,378 --> 02:44:58,613 CARE BUT WE NEED TO BRING IN 3964 02:44:58,613 --> 02:45:00,749 LINKS STRONGLY TO MENTAL HEALTH 3965 02:45:00,749 --> 02:45:01,016 PROVIDERS. 3966 02:45:01,016 --> 02:45:04,252 THOSE ARE THE TWO THAT WE REALLY 3967 02:45:04,252 --> 02:45:06,388 NEED TO MAKE SURE, OBVIOUSLY 3968 02:45:06,388 --> 02:45:10,158 PEDIATRICIANS ARE THERE AS WELL. 3969 02:45:10,158 --> 02:45:11,159 >> MELISSA, YOU'RE AWARE ORWH 3970 02:45:11,159 --> 02:45:12,794 HAS BEEN PARTNERING ON THE IDEA 3971 02:45:12,794 --> 02:45:15,730 STATES PROGRAM FOR SEVERAL YEARS 3972 02:45:15,730 --> 02:45:18,900 NOW AND NOW THERE'S THREE 3973 02:45:18,900 --> 02:45:21,002 CENTERS OF BIOMEDICAL RESEARCH 3974 02:45:21,002 --> 02:45:22,003 OF EXCELLENCE FOCUSED ON WOMEN'S 3975 02:45:22,003 --> 02:45:23,505 HEALTH, ALL THE THINGS ARE 3976 02:45:23,505 --> 02:45:24,506 COMING TOGETHER. 3977 02:45:24,506 --> 02:45:26,007 >> DR. ANDERSON AND THEN DR. 3978 02:45:26,007 --> 02:45:26,441 TEMPLETON. 3979 02:45:26,441 --> 02:45:28,443 >> THANK YOU FOR A WONDERFUL 3980 02:45:28,443 --> 02:45:29,945 TALK AND COMPELLING PERSONAL 3981 02:45:29,945 --> 02:45:32,047 STORY AND ALSO I WANT TO SAY FOR 3982 02:45:32,047 --> 02:45:33,848 ELEVATING THE ISSUES OF 3983 02:45:33,848 --> 02:45:34,783 ADOLESCENT GIRLS. 3984 02:45:34,783 --> 02:45:36,551 I THINK WE OFTEN DON'T PAY 3985 02:45:36,551 --> 02:45:39,721 ENOUGH ATTENTION TO THEIR HEALTH 3986 02:45:39,721 --> 02:45:39,955 ISSUES. 3987 02:45:39,955 --> 02:45:41,690 I WANTED TO DRAW ATTENTION TO 3988 02:45:41,690 --> 02:45:44,092 TWO OTHER PIECES YOU'VE HAD AND 3989 02:45:44,092 --> 02:45:45,293 BRING THEM TOGETHER. 3990 02:45:45,293 --> 02:45:48,463 THAT IS THE LACK OF THE REALLY 3991 02:45:48,463 --> 02:45:50,165 HIGH-QUALITY DATA TO GUIDE 3992 02:45:50,165 --> 02:45:50,966 CLINICAL PRACTICE, AND THEN WHAT 3993 02:45:50,966 --> 02:45:54,269 I SAW WAS A STRONG EMPHASIS ON 3994 02:45:54,269 --> 02:45:55,236 NEW ANALYTIC TOOLS WITH SHARED 3995 02:45:55,236 --> 02:45:55,570 DATA. 3996 02:45:55,570 --> 02:45:58,340 SO WHEN I THINK OF THOSE 3997 02:45:58,340 --> 02:45:59,874 ANALYTIC TOOLS, I'M A 3998 02:45:59,874 --> 02:46:01,509 STATISTICIAN BY TRAINING, I 3999 02:46:01,509 --> 02:46:04,779 THINK THOSE ARE REALLY BEST 4000 02:46:04,779 --> 02:46:06,181 SUITED FOR DISCOVERY WORK, IN 4001 02:46:06,181 --> 02:46:07,415 MOST CASES. 4002 02:46:07,415 --> 02:46:11,019 AND THEY NEED TO BE FOLLOWED UP 4003 02:46:11,019 --> 02:46:11,820 BY HIGH-QUALITY STUDIES AN 4004 02:46:11,820 --> 02:46:12,854 CLINICAL TRIALS. 4005 02:46:12,854 --> 02:46:14,623 MY QUESTION IS HOW IS NIH GOING 4006 02:46:14,623 --> 02:46:17,459 TO HELP BUILD THAT PIPELINE TO 4007 02:46:17,459 --> 02:46:19,527 FOLLOW ALL THESE NEW 4008 02:46:19,527 --> 02:46:20,462 DISCOVERIES, TO THE CLINICAL 4009 02:46:20,462 --> 02:46:22,263 TRIALS THAT WE NEED TO GUIDE 4010 02:46:22,263 --> 02:46:23,298 CLINICAL PRACTICE? 4011 02:46:23,298 --> 02:46:25,367 >> WHAT WE ENVISION IS THAT THE 4012 02:46:25,367 --> 02:46:27,435 NATIONAL LIBRARY OF MEDICINE CAN 4013 02:46:27,435 --> 02:46:30,271 BE A FOCAL POINT FOR ASKING 4014 02:46:30,271 --> 02:46:33,541 QUESTIONS, AND USING DATA TO 4015 02:46:33,541 --> 02:46:35,710 ADDRESS QUESTIONS AND BRINGING 4016 02:46:35,710 --> 02:46:38,013 TOGETHER COMMUNITIES OF 4017 02:46:38,013 --> 02:46:39,881 RESEARCHERS FOCUSED AROUND 4018 02:46:39,881 --> 02:46:40,615 PARTICULAR ISSUES, PARTICULAR 4019 02:46:40,615 --> 02:46:41,750 AREAS OF PARTICULAR QUESTIONS. 4020 02:46:41,750 --> 02:46:43,718 I'LL GIVE AN EXAMPLE. 4021 02:46:43,718 --> 02:46:46,354 LET'S SAY THAT YOU CAME TO ME 4022 02:46:46,354 --> 02:46:50,725 AND YOU SAID, YOU KNOW, YOU WANT 4023 02:46:50,725 --> 02:46:53,128 TO LOOK AT REAL WORLD DATA, DATA 4024 02:46:53,128 --> 02:46:58,533 FROM THE CLINICAL CARE 4025 02:46:58,533 --> 02:46:59,534 ENVIRONMENT, NATIONWIDE, ABOUT 4026 02:46:59,534 --> 02:47:00,335 ADOLESCENT GIRLS' MENTAL HEALTH, 4027 02:47:00,335 --> 02:47:03,204 I DON'T KNOW, MAKING THIS UP ON 4028 02:47:03,204 --> 02:47:04,939 THE FLY, RIGHT? 4029 02:47:04,939 --> 02:47:07,909 THOSE DATA WOULD -- YOU WOULD BE 4030 02:47:07,909 --> 02:47:09,978 WHAT WE HOPE TO BUILD AND ARE 4031 02:47:09,978 --> 02:47:13,815 WAY TO GETTING THERE, WE WOULD 4032 02:47:13,815 --> 02:47:14,916 HAVE WITHIN THE NLM SOMEONE TO 4033 02:47:14,916 --> 02:47:20,255 HELP YOU WITH AC ACCESS TO THE 4034 02:47:20,255 --> 02:47:22,557 DATASET TO INTERROGATE THE DATA, 4035 02:47:22,557 --> 02:47:24,025 SUPPORT THE ANALYTICS, FEDERATED 4036 02:47:24,025 --> 02:47:26,594 SYSTEMS, DATA WOULD BE CALLED 4037 02:47:26,594 --> 02:47:27,362 IN, CLOUD-BASED ENVIRONMENT 4038 02:47:27,362 --> 02:47:30,331 WHERE THEY WOULD HAVE ANALYTICS 4039 02:47:30,331 --> 02:47:31,299 SUPPLIED, SUPPORT FOR ANALYTICS. 4040 02:47:31,299 --> 02:47:32,734 LET'S SAY YOU WEREN'T A 4041 02:47:32,734 --> 02:47:35,036 STATISTICS, NEEDED TO BE LINKED 4042 02:47:35,036 --> 02:47:35,904 UP WITH SOMEONE. 4043 02:47:35,904 --> 02:47:38,740 THOSE DATA WOULD BE USED TO COME 4044 02:47:38,740 --> 02:47:41,242 UP WITH HYPOTHESES, EXACTLY 4045 02:47:41,242 --> 02:47:41,509 RIGHT. 4046 02:47:41,509 --> 02:47:43,545 AND THEN THAT SAME 4047 02:47:43,545 --> 02:47:45,413 ENVIRONMENT -- THEN THAT, YOU 4048 02:47:45,413 --> 02:47:50,018 WOULD BE WITHIN NIH, WE WOULD 4049 02:47:50,018 --> 02:47:52,887 ALSO INVITE THOSE ACROSS THE 4050 02:47:52,887 --> 02:47:54,756 INSTITUTES AND CENTERS WHO ARE 4051 02:47:54,756 --> 02:47:57,392 INTERESTED, YOU KNOW, WHO COULD 4052 02:47:57,392 --> 02:47:59,994 FURTHER THAT WORK THROUGH THE 4053 02:47:59,994 --> 02:48:01,663 DEVELOPMENT INTO CLINICAL TRIALS 4054 02:48:01,663 --> 02:48:04,399 COULD ALSO BE INVITED INTO THAT 4055 02:48:04,399 --> 02:48:05,033 RESEARCH ENVIRONMENT. 4056 02:48:05,033 --> 02:48:07,802 YOU SEE WHAT I MEAN? 4057 02:48:07,802 --> 02:48:10,638 WE WOULD HOPE THAT THE DISCOVERY 4058 02:48:10,638 --> 02:48:11,639 IDEALLY THOSE WORKING ON 4059 02:48:11,639 --> 02:48:13,942 DISCOVERY WOULD BE WORKING HAND 4060 02:48:13,942 --> 02:48:18,346 IN HAND IN THOSE CENTERS TO 4061 02:48:18,346 --> 02:48:19,948 FURTHER WHAT IS IDENTIFIED. 4062 02:48:19,948 --> 02:48:22,450 BUT EVEN IF IT'S NOT, THIS IS 4063 02:48:22,450 --> 02:48:22,784 NIH. 4064 02:48:22,784 --> 02:48:24,786 WE CAN FIND SOMEBODY WHO CAN 4065 02:48:24,786 --> 02:48:26,855 HELP YOU, RIGHT? 4066 02:48:26,855 --> 02:48:28,156 >> WHAT I UNDERSTAND IS WORK 4067 02:48:28,156 --> 02:48:29,891 FROM DISCOVERY CAN GO INTO 4068 02:48:29,891 --> 02:48:31,326 OBSERVATIONAL WORK IN THIS DATA 4069 02:48:31,326 --> 02:48:32,227 LIKE YOU'RE TALKING ABOUT AND 4070 02:48:32,227 --> 02:48:34,362 THEN WE NEED TO MAKE THE NEXT 4071 02:48:34,362 --> 02:48:39,100 STEP, IT MIGHT BE PRIMARY CARE 4072 02:48:39,100 --> 02:48:39,701 NETWORK YOU'RE TALKING ABOUT, 4073 02:48:39,701 --> 02:48:40,502 COULD BE GETTING INTO THE 4074 02:48:40,502 --> 02:48:43,371 CLINICAL TRIALS IS WHAT WE NEED. 4075 02:48:43,371 --> 02:48:45,140 >> WE'LL PULL ALL AVAILABLE DATA 4076 02:48:45,140 --> 02:48:49,410 RESOURCES TO ADDRESS THE ISSUES, 4077 02:48:49,410 --> 02:48:50,512 INCLUDING LEGACY OBSERVATIONAL 4078 02:48:50,512 --> 02:48:53,715 TRIALS, AND THE ABILITY TO 4079 02:48:53,715 --> 02:48:57,418 LAUNCH CLINICAL TRIALS. 4080 02:48:57,418 --> 02:48:57,719 >> KIM? 4081 02:48:57,719 --> 02:48:58,486 >> HI. 4082 02:48:58,486 --> 02:48:59,487 THANK YOU FOR THE GREAT 4083 02:48:59,487 --> 02:49:00,054 PRESENTATION TODAY. 4084 02:49:00,054 --> 02:49:04,592 AND A FEW WEEKS AGO, BOTH 4085 02:49:04,592 --> 02:49:05,960 AMAZING PRESENTATIONS. 4086 02:49:05,960 --> 02:49:07,896 AS A DISCLAIMER, I'M AN 4087 02:49:07,896 --> 02:49:09,330 ORTHOPEDIC SURGEON, THAT'S THE 4088 02:49:09,330 --> 02:49:10,431 BIAS I BRING IN. 4089 02:49:10,431 --> 02:49:17,205 THANK YOU SO MUCH FOR INCLUDING 4090 02:49:17,205 --> 02:49:18,506 US, OSTEOPOROSIS IN OLDER WOMEN. 4091 02:49:18,506 --> 02:49:20,608 WONDERING IF THERE ARE WAYS OF 4092 02:49:20,608 --> 02:49:23,211 ADDING OTHER CONDITIONS, YOU 4093 02:49:23,211 --> 02:49:26,047 TALKED ABOUT THE LINK WITH 4094 02:49:26,047 --> 02:49:27,582 INFLAMMATION, LACK OF ACTIVITY, 4095 02:49:27,582 --> 02:49:30,318 I WOULD BRING IN OBESITY AND 4096 02:49:30,318 --> 02:49:31,519 CARDIOVASCULAR RISK, OFTEN FOR 4097 02:49:31,519 --> 02:49:34,055 WOMEN THE COMMON LINK AMONG THAT 4098 02:49:34,055 --> 02:49:36,224 IS JOINT PAIN AND 4099 02:49:36,224 --> 02:49:36,825 OSTEOARTHRITIS. 4100 02:49:36,825 --> 02:49:37,926 THAT'S A VERY COMMON CONDITION 4101 02:49:37,926 --> 02:49:40,929 AS YOU KNOW TAKEN CARE OF BY 4102 02:49:40,929 --> 02:49:42,897 PRIMARY CARE PROVIDERS, FOR 4103 02:49:42,897 --> 02:49:46,067 WOMEN IN PARTICULAR THOSE WITH 4104 02:49:46,067 --> 02:49:47,268 JOINT PAIN ESPECIALLY OF THE 4105 02:49:47,268 --> 02:49:49,237 KNEE AND ESPECIALLY IF THEY HAVE 4106 02:49:49,237 --> 02:49:50,305 RADIOGRAPHIC CHANGES CONSISTENT 4107 02:49:50,305 --> 02:49:53,942 WITH O.A., THERE'S HIGHER RATE 4108 02:49:53,942 --> 02:49:54,509 OF COMORBIDITIES ESPECIALLY 4109 02:49:54,509 --> 02:49:56,277 CARDIOVASCULAR DISEASE AND 4110 02:49:56,277 --> 02:49:57,912 HIGHER RATE OF 4111 02:49:57,912 --> 02:50:00,548 CARDIOVASCULAR-RELATED 4112 02:50:00,548 --> 02:50:01,416 MORTALITY. 4113 02:50:01,416 --> 02:50:03,685 SO, IS OSTEOARTHRITIS A 4114 02:50:03,685 --> 02:50:05,653 CONDITION BEING LOOKED AT IN 4115 02:50:05,653 --> 02:50:07,722 OLDER WOMEN, IS THERE PERHAPS A 4116 02:50:07,722 --> 02:50:10,258 WAY TO GET THIS ON THE AGENDA AS 4117 02:50:10,258 --> 02:50:11,693 AREA OF EMPHASIS WITH 4118 02:50:11,693 --> 02:50:12,360 OSTEOPOROSIS? 4119 02:50:12,360 --> 02:50:13,995 >> YOU RAISE A GOOD ONE, ONE 4120 02:50:13,995 --> 02:50:15,763 THAT'S ALREADY UNDER INTENSE 4121 02:50:15,763 --> 02:50:18,366 STUDY FRANKLY IN THE HEAL 4122 02:50:18,366 --> 02:50:22,170 INITIATIVE, WHICH IS A REALLY 4123 02:50:22,170 --> 02:50:25,807 COMPREHENSIVE, AGAIN, 4124 02:50:25,807 --> 02:50:27,976 MULTI-INSTITUTE AND CENTER 4125 02:50:27,976 --> 02:50:31,746 EFFORT TO REDUCE OPIOID USE BUT 4126 02:50:31,746 --> 02:50:35,550 THE WHOLE PURPOSE OF THE HEAL 4127 02:50:35,550 --> 02:50:36,451 INITIATIVE PEOPLE DON'T USE IT 4128 02:50:36,451 --> 02:50:37,585 BECAUSE THEY WANT A GOOD TIME. 4129 02:50:37,585 --> 02:50:39,153 THEY ARE USING IT BECAUSE THEY 4130 02:50:39,153 --> 02:50:41,422 ARE SUFFERING FOR ONE REASON OR 4131 02:50:41,422 --> 02:50:42,223 KNOW. 4132 02:50:42,223 --> 02:50:45,727 OSTEOARTHRITIS, PAIN IN OLDER 4133 02:50:45,727 --> 02:50:48,229 PEOPLE, DUE TO DEGENERATIVE 4134 02:50:48,229 --> 02:50:49,764 JOINT DISEASE, IS ONE OF THE -- 4135 02:50:49,764 --> 02:50:51,232 YOU KNOW, A SIGNIFICANT AREA OF 4136 02:50:51,232 --> 02:50:54,002 FOCUS FOR THE HEAL INITIATIVE. 4137 02:50:54,002 --> 02:50:55,436 THAT'S ONE EXAMPLE I HAPPEN TO 4138 02:50:55,436 --> 02:50:58,706 BE ABLE TO PULL UP IMMEDIATELY. 4139 02:50:58,706 --> 02:51:00,909 IN NO WAY I MEANT TO BE 4140 02:51:00,909 --> 02:51:02,176 COMPREHENSIVE WHAT WE'VE GOT 4141 02:51:02,176 --> 02:51:03,311 GOING ON IN WOMEN'S HEALTH 4142 02:51:03,311 --> 02:51:03,945 ACROSS NIH. 4143 02:51:03,945 --> 02:51:06,381 THE OTHER THING I'LL TELL YOU 4144 02:51:06,381 --> 02:51:07,682 SINCE YOU'RE AN ORTHOPEDIC 4145 02:51:07,682 --> 02:51:09,217 SURGEON, ONE HUGE GAP WE HAVE IS 4146 02:51:09,217 --> 02:51:12,153 WE DON'T HAVE GREAT DATA FOR 4147 02:51:12,153 --> 02:51:14,255 WOMEN ATHLETES, RIGHT? 4148 02:51:14,255 --> 02:51:17,659 THE DATA THAT WE HAVE FOR 4149 02:51:17,659 --> 02:51:20,461 TRAINING, FOR SUPPORT, FOR CARE, 4150 02:51:20,461 --> 02:51:22,130 IS BASED ALMOST ENTIRELY ON MALE 4151 02:51:22,130 --> 02:51:22,563 ATHLETES. 4152 02:51:22,563 --> 02:51:24,632 IT'S ONE OF THE FEW AREAS THERE 4153 02:51:24,632 --> 02:51:25,633 REALLY AREN'T THAT MANY AREAS 4154 02:51:25,633 --> 02:51:27,936 WHERE WE DON'T HAVE ANY DATA FOR 4155 02:51:27,936 --> 02:51:29,137 WOMEN, BUT SPORTS MEDICINE IS 4156 02:51:29,137 --> 02:51:31,205 ONE OF THEM. 4157 02:51:31,205 --> 02:51:36,144 WE REALLY LACK REALLY GOOD DATA 4158 02:51:36,144 --> 02:51:37,111 ON MUSCULOSKELETAL PHYSIOLOGY 4159 02:51:37,111 --> 02:51:38,880 AND HEALTH FOR WOMEN. 4160 02:51:38,880 --> 02:51:40,815 SO THAT'S ANOTHER ONE FOR YOU. 4161 02:51:40,815 --> 02:51:42,917 >> I WOULD AGREE. 4162 02:51:42,917 --> 02:51:45,853 IT'S MOSTLY BECAUSE MOST 4163 02:51:45,853 --> 02:51:47,288 STUDIES, THE DATA ISN'T 4164 02:51:47,288 --> 02:51:48,957 DISAGGREGATED ON SEX. 4165 02:51:48,957 --> 02:51:52,894 IF YOU LOOK AT ANTERIOR CRUCIATE 4166 02:51:52,894 --> 02:51:54,429 LIGAMENT ISSUES, LOTS OF 4167 02:51:54,429 --> 02:51:56,064 RESEARCH FOCUSED ON ANATOMIC 4168 02:51:56,064 --> 02:51:58,066 PARAMETERS DIFFERENT, WHICH IS 4169 02:51:58,066 --> 02:51:59,233 GREAT, BUT THERE'S NOT MUCH 4170 02:51:59,233 --> 02:52:01,102 SURGICALLY YOU CAN DO TO FIX 4171 02:52:01,102 --> 02:52:02,470 THAT, RATHER THAN HAVING A FIX 4172 02:52:02,470 --> 02:52:06,040 THAT WOULD BE BASED ON TRAINING. 4173 02:52:06,040 --> 02:52:07,875 SO, YES, STUDIES LOOKING AT 4174 02:52:07,875 --> 02:52:08,676 NEUROMUSCULAR CONTROL YOU CAN 4175 02:52:08,676 --> 02:52:10,178 ADDRESS WITH TRAINING BUT WHEN 4176 02:52:10,178 --> 02:52:12,480 LOOKING AT TIBIAL SLOPE AND 4177 02:52:12,480 --> 02:52:13,915 NOTCH WITH ACL SIZE, GREAT, BUT 4178 02:52:13,915 --> 02:52:15,416 THERE'S NOTHING YOU CAN DO TO 4179 02:52:15,416 --> 02:52:18,286 TRY TO ADDRESS THAT FROM A 4180 02:52:18,286 --> 02:52:19,287 PREVENTION STANDPOINT. 4181 02:52:19,287 --> 02:52:22,991 >> INTERESTING NEW DATA SHOWING 4182 02:52:22,991 --> 02:52:25,827 HORMONAL INFLUENCES ON LIGAMENT 4183 02:52:25,827 --> 02:52:27,128 INSTABILITY, ANY PREGNANT WOMAN 4184 02:52:27,128 --> 02:52:29,130 CAN TELL YOU THAT, IT EXTENDS 4185 02:52:29,130 --> 02:52:31,299 WAY BEYOND THAT WE'RE FINDING. 4186 02:52:31,299 --> 02:52:36,204 >> KIM, YOU MAY NOT BE AWARE DR. 4187 02:52:36,204 --> 02:52:40,975 CRISEL IS IN THE ROOM, I'LL GIVE 4188 02:52:40,975 --> 02:52:41,943 A SECOND TO RESPOND. 4189 02:52:41,943 --> 02:52:44,245 DO YOU WANT TO MAKE A COMMENT? 4190 02:52:44,245 --> 02:52:45,646 >> I DID NOT PLANT THAT 4191 02:52:45,646 --> 02:52:46,147 QUESTION. 4192 02:52:46,147 --> 02:52:47,982 I'VE BEEN BEAMING HERE EACH TIME 4193 02:52:47,982 --> 02:52:51,119 THE SUBJECT COMES UP. 4194 02:52:51,119 --> 02:52:51,886 YES, ARTHRITIS INITIATIVE, HUGE 4195 02:52:51,886 --> 02:52:53,321 INVESTMENT BY THE INSTITUTE. 4196 02:52:53,321 --> 02:52:55,823 THE DATA ARE STILL AVAILABLE AND 4197 02:52:55,823 --> 02:52:57,258 THE BIOSPECIMENS, I WANTED TO 4198 02:52:57,258 --> 02:53:02,897 POINT OUT THERE'S A BIG HEAL 4199 02:53:02,897 --> 02:53:04,532 INITIATIVE FOCUSING ON THE KNEE, 4200 02:53:04,532 --> 02:53:08,736 WAIT JOINT AND TISSUES ARE 4201 02:53:08,736 --> 02:53:09,604 ENERVATED, AND OSTEOARTHRITIS 4202 02:53:09,604 --> 02:53:11,239 BELONGS IN THE PORTFOLIO FOR 4203 02:53:11,239 --> 02:53:11,906 WOMEN'S HEALTH RESEARCH. 4204 02:53:11,906 --> 02:53:14,742 THANK YOU SO MUCH FOR YOUR 4205 02:53:14,742 --> 02:53:15,510 ADVOCACY, KIM. 4206 02:53:15,510 --> 02:53:17,712 >> THANK YOU. 4207 02:53:17,712 --> 02:53:18,579 I APPRECIATE THAT. 4208 02:53:18,579 --> 02:53:19,847 >> I THINK WE'RE GOING TO GIVE 4209 02:53:19,847 --> 02:53:23,384 YOU THE LAST QUESTION SO WE CAN 4210 02:53:23,384 --> 02:53:26,587 RESPECT DR. BERTAGNOLLI'S TIME. 4211 02:53:26,587 --> 02:53:27,688 >> THANK YOU. 4212 02:53:27,688 --> 02:53:29,190 SOCIETY FOR WOMEN'S HEALTH 4213 02:53:29,190 --> 02:53:29,690 RESEARCH. 4214 02:53:29,690 --> 02:53:32,960 I LOVE THE WAY YOU PUT THAT WE 4215 02:53:32,960 --> 02:53:35,029 DON'T STOP AT DISCOVERY. 4216 02:53:35,029 --> 02:53:36,764 AND THAT IT'S REALLY UNTIL 4217 02:53:36,764 --> 02:53:37,965 INDIVIDUALS ARE HEALTHY, SO MY 4218 02:53:37,965 --> 02:53:41,269 QUESTION TO YOU, WE OFTEN HAVE 4219 02:53:41,269 --> 02:53:43,771 SEEN IN MY SPACE THE 4220 02:53:43,771 --> 02:53:45,073 COLLABORATION ACROSS 4221 02:53:45,073 --> 02:53:45,506 DISCIPLINES. 4222 02:53:45,506 --> 02:53:47,475 I LIKE THE PRIMARY CARE NETWORK 4223 02:53:47,475 --> 02:53:50,878 BUT ARE THERE ANY PLANS FOR 4224 02:53:50,878 --> 02:53:54,449 EITHER LOOKING AT INFRASTRUCTURE 4225 02:53:54,449 --> 02:53:56,250 OR PARTNERING OUTSIDE THE 4226 02:53:56,250 --> 02:53:58,653 PRIMARY CARE NETWORK TO MAKE 4227 02:53:58,653 --> 02:54:00,521 SURE THE OTHER PROFESSIONS OR 4228 02:54:00,521 --> 02:54:04,125 PLAYERS IN THIS SPACE EITHER 4229 02:54:04,125 --> 02:54:06,661 BEING PAYERS OR PRACTITIONERS OR 4230 02:54:06,661 --> 02:54:08,429 RESEARCHERS ARE ENGAGING TO MAKE 4231 02:54:08,429 --> 02:54:09,530 SURE DISCOVERIES MEET THE NEEDS 4232 02:54:09,530 --> 02:54:10,398 OF THE POPULATION. 4233 02:54:10,398 --> 02:54:17,839 >> I ANTICIPATE THE PRIMARY 4234 02:54:17,839 --> 02:54:19,173 CARE NETWORK WILL ADDRESS 4235 02:54:19,173 --> 02:54:20,908 STUDIES OF PRIMARY CARE, IS 4236 02:54:20,908 --> 02:54:24,178 THERE A BETTER WAY TO HANDLE 4237 02:54:24,178 --> 02:54:27,748 OSTEOARTHRITIS IN THE KNEE OF AN 4238 02:54:27,748 --> 02:54:29,317 85-YEAR-OLD WOMAN. 4239 02:54:29,317 --> 02:54:32,520 IT WILL HELP US HANDLE ISSUES 4240 02:54:32,520 --> 02:54:34,255 RELATED TO HEALTH DELIVERY AND 4241 02:54:34,255 --> 02:54:34,589 HEALTH CARE. 4242 02:54:34,589 --> 02:54:36,357 AND A LOT OF THOSE, YOU KNOW, 4243 02:54:36,357 --> 02:54:39,393 ARE GOING TO BE HANDOFFS TO 4244 02:54:39,393 --> 02:54:40,595 OTHER SPECIALISTS, COORDINATION 4245 02:54:40,595 --> 02:54:42,497 OF CARE WITH OTHER SPECIALISTS, 4246 02:54:42,497 --> 02:54:44,398 THAT'S JUST ONE PART. 4247 02:54:44,398 --> 02:54:47,168 I UNDERSTAND THAT THERE ARE 4248 02:54:47,168 --> 02:54:49,370 SO -- THERE'S A TREMENDOUS NEED 4249 02:54:49,370 --> 02:54:50,805 FOR SPECIALTY RESEARCH AND THE 4250 02:54:50,805 --> 02:54:54,442 ABILITY TO DO THAT FOR WOMEN AND 4251 02:54:54,442 --> 02:54:55,309 TO PROMOTE WOMEN'S HEALTH. 4252 02:54:55,309 --> 02:55:01,182 WHAT HAPPENED SO FAR ALL 4253 02:55:01,182 --> 02:55:01,949 INSTITUTES AND CENTERS HAVE 4254 02:55:01,949 --> 02:55:03,918 THEIR OWN PARTICULAR FOCUS OF 4255 02:55:03,918 --> 02:55:09,290 DISEASE, AND I DO THINK AS WE 4256 02:55:09,290 --> 02:55:12,026 ARE -- OUR MANDATE IS THAT WE DO 4257 02:55:12,026 --> 02:55:12,994 ELIMINATE SILOS AND COLLABORATE 4258 02:55:12,994 --> 02:55:14,829 MUCH MORE ACROSS THOSE DISEASES 4259 02:55:14,829 --> 02:55:18,132 ON SOME OF THE FUNDAMENTAL 4260 02:55:18,132 --> 02:55:20,201 ISSUES THAT UNDERLIE THE 4261 02:55:20,201 --> 02:55:21,869 DIFFERENT CONDITIONS. 4262 02:55:21,869 --> 02:55:23,404 WHEN IT COMES TO CLINICAL 4263 02:55:23,404 --> 02:55:25,940 TRIALS, I WOULD EXPECT TO SEE 4264 02:55:25,940 --> 02:55:28,543 OUR INDIVIDUAL INSTITUTES AND 4265 02:55:28,543 --> 02:55:30,511 CENTERS THAT MAINTAIN THEIR 4266 02:55:30,511 --> 02:55:31,512 SPECIALLY NETWORKS, LIKE THIS IS 4267 02:55:31,512 --> 02:55:32,713 NEVER GOING TO REPLACE THE 4268 02:55:32,713 --> 02:55:34,448 NATIONAL CLINICAL TRIALS NETWORK 4269 02:55:34,448 --> 02:55:36,083 FOR CANCER CLINICAL TRIALS BUT 4270 02:55:36,083 --> 02:55:37,552 IT WILL BE A GREAT COMPLEMENT TO 4271 02:55:37,552 --> 02:55:37,718 IT. 4272 02:55:37,718 --> 02:55:42,356 SAME FOR MANY OF THE OTHER 4273 02:55:42,356 --> 02:55:45,626 CONDITIONS THAT AFFECT WOMEN. 4274 02:55:45,626 --> 02:55:47,995 LINDSAY, WILL YOU MAINTAIN YOUR 4275 02:55:47,995 --> 02:55:50,765 NETWORKS AS THEY ARE WITH 4276 02:55:50,765 --> 02:55:53,267 COMPLEMENTS FROM THE PRIMARY 4277 02:55:53,267 --> 02:55:53,935 CARE NETWORK? 4278 02:55:53,935 --> 02:55:55,803 >> WELL, AS A SMALL INSTITUTE, 4279 02:55:55,803 --> 02:55:57,572 WE DON'T HAVE NETWORKS THAT 4280 02:55:57,572 --> 02:55:58,973 SUPPORT RESEARCH SO WE'RE REALLY 4281 02:55:58,973 --> 02:56:00,741 COUNTING ON THIS PRIMARY CARE 4282 02:56:00,741 --> 02:56:02,910 NETWORK TO BE SOMETHING WE CAN 4283 02:56:02,910 --> 02:56:03,177 LEVERAGE. 4284 02:56:03,177 --> 02:56:04,512 TO YOUR POINT WE'RE HOPING THERE 4285 02:56:04,512 --> 02:56:06,514 WILL BE OPPORTUNITIES TO KIND OF 4286 02:56:06,514 --> 02:56:09,250 BRING IN THE SPECIALTY CARE, YOU 4287 02:56:09,250 --> 02:56:11,652 KNOW, A LOT OF PROBLEMS THAT ARE 4288 02:56:11,652 --> 02:56:12,753 MANAGED IN PRIMARY CARE OF 4289 02:56:12,753 --> 02:56:14,088 COURSE REQUIRE COORDINATION WITH 4290 02:56:14,088 --> 02:56:16,157 SPECIALISTS SO WE WANT TO BE 4291 02:56:16,157 --> 02:56:18,859 ABLE TO BUILD OUT FROM THOSE 4292 02:56:18,859 --> 02:56:20,228 CORES OF PRIMARY CARE NETWORK, 4293 02:56:20,228 --> 02:56:22,797 BUT WE'RE LOOKING TO THIS TO 4294 02:56:22,797 --> 02:56:26,200 HELP EXTEND AND SUPPORT RESEARCH 4295 02:56:26,200 --> 02:56:28,402 IN OUR AREAS. 4296 02:56:28,402 --> 02:56:30,805 >> OUR FIRST FOCUS WILL BE ON 4297 02:56:30,805 --> 02:56:31,872 CARE DELIVERY, SPECIFIC PROJECTS 4298 02:56:31,872 --> 02:56:33,407 WE CAN GET OUR ARMS AROUND THAT 4299 02:56:33,407 --> 02:56:38,813 WILL LET US LAUNCH THAT THROUGH 4300 02:56:38,813 --> 02:56:39,780 THE NETWORK. 4301 02:56:39,780 --> 02:56:40,114 >> QUICKLY. 4302 02:56:40,114 --> 02:56:42,183 >> TO FOLLOW UP ON THE LAST 4303 02:56:42,183 --> 02:56:45,353 POINT, THINKING A TAD MORE 4304 02:56:45,353 --> 02:56:47,922 UPSTREAM OF PRIMARY CARE, FOR 4305 02:56:47,922 --> 02:56:49,290 UNDERSERVED COMMUNITIES THAT 4306 02:56:49,290 --> 02:56:53,127 MIGHT HAVE TROUBLE ACCESSING 4307 02:56:53,127 --> 02:56:54,462 PRIMARY CARE, THEY WAIT TOO 4308 02:56:54,462 --> 02:56:56,631 LATE, BY THE TIME THEY GET TO 4309 02:56:56,631 --> 02:56:58,399 PRIMARY CARE THEY LOST 4310 02:56:58,399 --> 02:56:59,433 PREVENTIVE EFFORT. 4311 02:56:59,433 --> 02:57:01,769 FOLLOWING UP ON YOUR SCREENING 4312 02:57:01,769 --> 02:57:03,204 AND OTHERS AROUND PRIMARY CARE 4313 02:57:03,204 --> 02:57:04,705 PROVIDERS BUT I WAS THINKING 4314 02:57:04,705 --> 02:57:06,907 EVEN IN THE COMMUNITY MORE IN 4315 02:57:06,907 --> 02:57:09,510 PUBLIC HEALTH TYPE OF COMMUNITY 4316 02:57:09,510 --> 02:57:09,777 SETTINGS. 4317 02:57:09,777 --> 02:57:11,212 >> THERE'S A LOT OF DISCUSSION 4318 02:57:11,212 --> 02:57:14,915 GOING ON ABOUT THE INTERFACE 4319 02:57:14,915 --> 02:57:15,883 BETWEEN PUBLIC HEALTH AND 4320 02:57:15,883 --> 02:57:18,185 RESEARCH THAT WE DO AT NIH. 4321 02:57:18,185 --> 02:57:20,721 AND THE FIRST STEP TOWARD 4322 02:57:20,721 --> 02:57:22,156 UNDERSTANDING THAT, BEING ABLE 4323 02:57:22,156 --> 02:57:23,791 TO RESOURCE IT AND BUILD IT IS 4324 02:57:23,791 --> 02:57:25,192 FRANKLY IN THE AREA OF DATA 4325 02:57:25,192 --> 02:57:27,495 RIGHT NOW. 4326 02:57:27,495 --> 02:57:30,331 WE'RE COOPERATING WITH CDC, CMS, 4327 02:57:30,331 --> 02:57:31,866 VERY CLOSELY ON OUR DATA, NEW 4328 02:57:31,866 --> 02:57:32,700 DATA INFRASTRUCTURE. 4329 02:57:32,700 --> 02:57:36,270 THAT WILL HELP US DO THAT. 4330 02:57:36,270 --> 02:57:37,038 THANKS. 4331 02:57:37,038 --> 02:57:40,841 >> PLEASE JOIN ME IN THANKING 4332 02:57:40,841 --> 02:57:43,344 DR. BERTAGNOLLI. 4333 02:57:43,344 --> 02:57:47,748 4334 02:57:47,748 --> 02:57:49,383 WITH THAT, I THINK WE'LL MOVE TO 4335 02:57:49,383 --> 02:57:51,452 THE NEXT PRESENTATION. 4336 02:57:51,452 --> 02:58:01,962 I'M DELIGHTED TO INTRODUCE DR. 4337 02:58:02,163 --> 02:58:05,032 CAROLYN MAZURE, THE PROFESSOR IN 4338 02:58:05,032 --> 02:58:06,667 WOMEN'S HEALTH RESEARCH, AND 4339 02:58:06,667 --> 02:58:08,569 PROFESSOR OF PSYCHIATRY AND 4340 02:58:08,569 --> 02:58:11,172 PSYCHOLOGY YALE SCHOOL OF 4341 02:58:11,172 --> 02:58:11,706 MEDICINE. 4342 02:58:11,706 --> 02:58:15,109 BUT IN NOVEMBER SHE JOINED THE 4343 02:58:15,109 --> 02:58:16,077 ADMINISTRATION, WHEN THE 4344 02:58:16,077 --> 02:58:16,744 PRESIDENT ANNOUNCED THE LAUNCH 4345 02:58:16,744 --> 02:58:19,814 OF THE WHITE HOUSE WOMEN'S 4346 02:58:19,814 --> 02:58:24,618 HEALTH INITIATIVE, AND SHE WAS 4347 02:58:24,618 --> 02:58:26,253 SELECTED TO CHAIR. 4348 02:58:26,253 --> 02:58:27,455 THIS IS COMING ALSO OUT OF THE 4349 02:58:27,455 --> 02:58:32,493 OFFICE OF THE FIRST LADY, AND I 4350 02:58:32,493 --> 02:58:33,794 CAN'T IMAGINE A BETTER PERSON TO 4351 02:58:33,794 --> 02:58:36,063 HEAD THIS UP. 4352 02:58:36,063 --> 02:58:37,431 DR. MAZURE HAS A LONGSTANDING 4353 02:58:37,431 --> 02:58:41,936 RECORD OF BUILDING A WOMEN'S 4354 02:58:41,936 --> 02:58:42,703 HEALTH RESEARCH CENTER 4355 02:58:42,703 --> 02:58:44,739 INTERDISCIPLINARY AT YALE AND 4356 02:58:44,739 --> 02:58:47,074 HER BACKGROUND IS IN THE AREA OF 4357 02:58:47,074 --> 02:58:47,408 DEPRESSION. 4358 02:58:47,408 --> 02:58:49,043 SUCH A CRITICAL AREA FOR THE 4359 02:58:49,043 --> 02:58:50,144 HEALTH OF WOMEN. 4360 02:58:50,144 --> 02:58:55,883 PLEASE JOIN ME IN WELCOMING DR. 4361 02:58:55,883 --> 02:58:56,717 CAROLYN MAZURE. 4362 02:58:56,717 --> 02:58:58,786 >> THANK YOU SO MUCH, JANINE, 4363 02:58:58,786 --> 02:59:00,121 FOR THAT INTRODUCTION. 4364 02:59:00,121 --> 02:59:05,292 AND MY THANKS TO THE OFFICE OF 4365 02:59:05,292 --> 02:59:06,026 RESEARCH ON WOMEN'S HEALTH TO 4366 02:59:06,026 --> 02:59:08,896 TALK ABOUT THE FIRST EVER WHITE 4367 02:59:08,896 --> 02:59:09,964 HOUSE INITIATIVE ON WOMEN'S 4368 02:59:09,964 --> 02:59:11,832 HEALTH RESEARCH. 4369 02:59:11,832 --> 02:59:13,267 I THANK DR. BERTAGNOLLI FOR 4370 02:59:13,267 --> 02:59:14,034 MENTIONING IT. 4371 02:59:14,034 --> 02:59:15,870 IT'S REALLY IMPORTANT THAT IT'S 4372 02:59:15,870 --> 02:59:19,940 ON HER MIND AND I OBVIOUSLY 4373 02:59:19,940 --> 02:59:21,342 APPRECIATE HER PARTNERSHIP IN 4374 02:59:21,342 --> 02:59:21,542 THAT. 4375 02:59:21,542 --> 02:59:23,444 SO WHAT I THOUGHT I'D DO TODAY 4376 02:59:23,444 --> 02:59:24,745 IS TRY TO DESCRIBE THE 4377 02:59:24,745 --> 02:59:26,614 INITIATIVE TO YOU. 4378 02:59:26,614 --> 02:59:28,816 IT'S QUITE BROAD, THERE'S A LOT 4379 02:59:28,816 --> 02:59:29,450 TO IT. 4380 02:59:29,450 --> 02:59:30,885 PEOPLE OFTEN ASK QUESTIONS ABOUT 4381 02:59:30,885 --> 02:59:31,852 HOW THIS REALLY WORKS. 4382 02:59:31,852 --> 02:59:35,256 THAT'S GOING TO BE MY ATTEMPT TO 4383 02:59:35,256 --> 02:59:36,791 DO THAT. 4384 02:59:36,791 --> 02:59:38,959 THE INITIATIVE WAS LAUNCHED AS 4385 02:59:38,959 --> 02:59:43,798 DR. CLAYTON INDICATED IN 4386 02:59:43,798 --> 02:59:45,332 NOVEMBER OF 2023, BY PRESIDENT 4387 02:59:45,332 --> 02:59:45,533 BIDEN. 4388 02:59:45,533 --> 02:59:49,136 AND IT IS LED BY THE FIRST LADY, 4389 02:59:49,136 --> 02:59:51,572 DR. JILL BIDEN. 4390 02:59:51,572 --> 02:59:54,175 IN CLOSE COLLABORATION WITH THE 4391 02:59:54,175 --> 02:59:57,912 WHITE HOUSE COUNCIL ON GENDER 4392 02:59:57,912 --> 02:59:58,345 POLICY. 4393 02:59:58,345 --> 03:00:01,182 AND I AM VERY HONORED TO BE THE 4394 03:00:01,182 --> 03:00:04,785 CHAIR OF THAT INITIATIVE IN MY 4395 03:00:04,785 --> 03:00:07,955 LEAVE FROM MEDICAL SCHOOL. 4396 03:00:07,955 --> 03:00:10,624 SO HERE WE ARE, MONICA SHOWED 4397 03:00:10,624 --> 03:00:12,393 YOU THIS, IN WHICH WE'RE PRESENT 4398 03:00:12,393 --> 03:00:15,429 AT THE SIGNING OF THE 4399 03:00:15,429 --> 03:00:16,096 PRESIDENTIAL MEMORANDUM. 4400 03:00:16,096 --> 03:00:20,000 AND WHAT I WANT PEOPLE TO 4401 03:00:20,000 --> 03:00:21,101 UNDERSTAND, THE OFFICE WAS KIND 4402 03:00:21,101 --> 03:00:23,204 ENOUGH TO PUT COPIES OF 4403 03:00:23,204 --> 03:00:24,705 FACTSHEETS AND OTHER MATERIAL, 4404 03:00:24,705 --> 03:00:26,574 THESE ARE PUBLIC DOCUMENTS FOR 4405 03:00:26,574 --> 03:00:28,209 YOU TO ACCESS AND READ IF 4406 03:00:28,209 --> 03:00:29,643 THERE'S ANY LACK OF CLARITY THEN 4407 03:00:29,643 --> 03:00:31,846 YOU CAN WRITE TO US AND ASK 4408 03:00:31,846 --> 03:00:32,279 QUESTIONS. 4409 03:00:32,279 --> 03:00:35,015 AND I'LL GET TO THAT IN A 4410 03:00:35,015 --> 03:00:36,016 MINUTE. 4411 03:00:36,016 --> 03:00:40,187 BUT THE PRESIDENT ESTABLISHED 4412 03:00:40,187 --> 03:00:40,988 THIS INITIATIVE ALSO AS DR. 4413 03:00:40,988 --> 03:00:42,156 BERTAGNOLLI INDICATED, AND THIS 4414 03:00:42,156 --> 03:00:46,961 IS A QUOTE FROM THE PRESIDENTIAL 4415 03:00:46,961 --> 03:00:48,362 MEMORANDUM. 4416 03:00:48,362 --> 03:00:49,597 FUNDAMENTALLY CHANGE HOW WE 4417 03:00:49,597 --> 03:00:53,634 APPROACH AND FUND WOMEN'S HEALTH 4418 03:00:53,634 --> 03:00:54,268 RESEARCH. 4419 03:00:54,268 --> 03:00:57,471 THIS IS BECAUSE ALTHOUGH WE HAVE 4420 03:00:57,471 --> 03:00:58,873 MADE MEANINGFUL PROGRESS IN 4421 03:00:58,873 --> 03:01:00,374 RESEARCH, PARTICULARLY OVER THE 4422 03:01:00,374 --> 03:01:02,943 LAST TWO DECADES ON THE HEALTH 4423 03:01:02,943 --> 03:01:06,547 OF WOMEN, AND A LOT OF THAT FROM 4424 03:01:06,547 --> 03:01:08,082 PEOPLE WHO WORKED WITH THIS 4425 03:01:08,082 --> 03:01:10,184 OFFICE, AND WORKED WITH NIH 4426 03:01:10,184 --> 03:01:14,221 GRANTS AND MANY OF YOU, THERE'S 4427 03:01:14,221 --> 03:01:18,058 STILL AN AWFUL LOT WE NEED TO 4428 03:01:18,058 --> 03:01:18,592 KNOW. 4429 03:01:18,592 --> 03:01:19,693 WE'VE HAD REVOLUTIONARY 4430 03:01:19,693 --> 03:01:20,394 DISCOVERIES IN CERTAIN 4431 03:01:20,394 --> 03:01:21,562 CONDITIONS AFFECTING WOMEN. 4432 03:01:21,562 --> 03:01:24,398 WE'VE INCREASED THE NUMBER OF 4433 03:01:24,398 --> 03:01:25,833 WOMEN PARTICIPATING IN CLINICAL 4434 03:01:25,833 --> 03:01:26,200 TRIALS. 4435 03:01:26,200 --> 03:01:32,606 BUT WE STILL KNOW TOO LITTLE HOW 4436 03:01:32,606 --> 03:01:33,707 TO EFFECTIVELY PREVENT, 4437 03:01:33,707 --> 03:01:36,877 DIAGNOSE, AND TREAT A WIDE RANGE 4438 03:01:36,877 --> 03:01:39,413 OF HEALTH CONDITIONS IN WOMEN 4439 03:01:39,413 --> 03:01:41,782 LEAVING WOMEN AND IMPORTANTLY AS 4440 03:01:41,782 --> 03:01:42,883 WE'RE HEARING TODAY THEIR HEALTH 4441 03:01:42,883 --> 03:01:45,953 CARE PROVIDERS WITHOUT THE TOOLS 4442 03:01:45,953 --> 03:01:48,055 NEEDED TO REALLY DEAL WITH THESE 4443 03:01:48,055 --> 03:01:48,923 IMPORTANT CONDITIONS. 4444 03:01:48,923 --> 03:01:53,294 AND CONDITIONS THAT AFFECT WOMEN 4445 03:01:53,294 --> 03:01:56,163 UNIQUELY, SUCH AS ENDOMETRIOSIS, 4446 03:01:56,163 --> 03:01:58,666 FIBROIDS, PREECLAMPSIA, A WIDE, 4447 03:01:58,666 --> 03:02:04,371 WIDE RANGE, CONDITIONS THAT 4448 03:02:04,371 --> 03:02:06,807 AFFECT WOMEN DISPROPORTIONATELY, 4449 03:02:06,807 --> 03:02:08,676 EXTREMELY LARGE RANGE, 4450 03:02:08,676 --> 03:02:09,843 ALZHEIMER'S DISEASE, MIGRAINE, 4451 03:02:09,843 --> 03:02:12,680 WIDE RANGE OF AUTOIMMUNE 4452 03:02:12,680 --> 03:02:14,682 DISORDERS 80% OF THOSE IN THE 4453 03:02:14,682 --> 03:02:17,184 UNITED STATES ARE WOMEN. 4454 03:02:17,184 --> 03:02:18,052 LUPUS, CELIAC DISEASE, 4455 03:02:18,052 --> 03:02:19,486 RHEUMATOID ARTHRITIS AS WELL AS, 4456 03:02:19,486 --> 03:02:23,324 AND THIS IS REALLY IMPORTANT TO 4457 03:02:23,324 --> 03:02:26,727 US, AS WELL AS WOMEN HAVING THE 4458 03:02:26,727 --> 03:02:31,198 GREATER LIKELIHOOD TO HAVE 4459 03:02:31,198 --> 03:02:31,966 ENDURING CONDITIONS, CHRONIC 4460 03:02:31,966 --> 03:02:33,534 CONDITIONS, AS WELL AS MULTIPLE 4461 03:02:33,534 --> 03:02:37,638 DISORDERS THAT OCCUR AT THE SAME 4462 03:02:37,638 --> 03:02:37,838 TIME. 4463 03:02:37,838 --> 03:02:39,306 ALSO CONDITIONS THAT AFFECT 4464 03:02:39,306 --> 03:02:40,608 WOMEN DIFFERENTLY THAN MEN. 4465 03:02:40,608 --> 03:02:42,810 SUCH AS THOSE FOUND IN HEART 4466 03:02:42,810 --> 03:02:47,081 DISEASE, AND IN MOST BRAIN-BASED 4467 03:02:47,081 --> 03:02:47,514 DISORDERS. 4468 03:02:47,514 --> 03:02:54,989 WHETHER IT'S SMOKING, OR 4469 03:02:54,989 --> 03:02:55,956 EPILEPSY, OR MULTIPLE SCLEROSIS, 4470 03:02:55,956 --> 03:02:58,258 WHERE WE LOOK WE FIND 4471 03:02:58,258 --> 03:02:58,692 DIFFERENCES. 4472 03:02:58,692 --> 03:03:00,894 TO CLOSE RESEARCH GAPS AND 4473 03:03:00,894 --> 03:03:01,996 PIONEER NEXT GENERATION OF 4474 03:03:01,996 --> 03:03:02,529 DISCOVERIES THE PRESIDENT 4475 03:03:02,529 --> 03:03:06,934 DIRECTED EACH OF THE 4476 03:03:06,934 --> 03:03:07,534 INITIATIVES' MEMBERS INCLUDING 4477 03:03:07,534 --> 03:03:08,335 THE DEPARTMENT OF HEALTH AND 4478 03:03:08,335 --> 03:03:11,605 HUMAN SERVICES AND NINE AGENCIES 4479 03:03:11,605 --> 03:03:14,241 WITHIN DHHS WHICH INCLUDES THE 4480 03:03:14,241 --> 03:03:16,076 NIH BUT ALSO CDC, FDA, IT GOES 4481 03:03:16,076 --> 03:03:21,148 ON AND ON, THERE ARE NINE 4482 03:03:21,148 --> 03:03:21,915 AGENCIES. 4483 03:03:21,915 --> 03:03:24,652 WE ALSO INCLUDED A NUMBER OF 4484 03:03:24,652 --> 03:03:26,253 FEDERAL AGENCIES BEYOND DHHS 4485 03:03:26,253 --> 03:03:30,858 SUCH AS DEPARTMENT OF DEFENSE, 4486 03:03:30,858 --> 03:03:32,159 VETERANS AFFAIRS, AND 4487 03:03:32,159 --> 03:03:32,860 PRESIDENTIAL MEMORANDUM REQUIRED 4488 03:03:32,860 --> 03:03:36,263 THAT ALL OF THESE AGENCIES 4489 03:03:36,263 --> 03:03:39,533 WITHIN 45 DAYS OF THE SIGNING OF 4490 03:03:39,533 --> 03:03:42,703 THE MEMORANDUM LOOK INTO THEIR 4491 03:03:42,703 --> 03:03:45,439 OWN PORTFOLIO AND DECIDE HOW 4492 03:03:45,439 --> 03:03:48,375 THEY CAN INCREASE WOMEN'S HEALTH 4493 03:03:48,375 --> 03:03:51,111 RESEARCH, FOR THOSE AGENCIES AND 4494 03:03:51,111 --> 03:03:53,514 DEPARTMENTS FOR WHICH THEY FUND 4495 03:03:53,514 --> 03:03:54,815 EXTERNALLY, THAT WAS REVIEWED 4496 03:03:54,815 --> 03:03:57,151 BUT ALSO FOR THE DEPARTMENTS 4497 03:03:57,151 --> 03:03:58,318 THAT INTERNALLY ARE LOOKING AT 4498 03:03:58,318 --> 03:04:00,421 THE HEALTH OF WOMEN AND DOING 4499 03:04:00,421 --> 03:04:01,922 SOME ASPECT OF RESEARCH WE ASK 4500 03:04:01,922 --> 03:04:04,892 THEM AS WELL TO THINK ABOUT WHAT 4501 03:04:04,892 --> 03:04:08,295 THEY COULD DO TO INCREASE AND 4502 03:04:08,295 --> 03:04:12,533 POTENTIALLY ADVANCE WOMEN'S 4503 03:04:12,533 --> 03:04:13,434 HEALTH RESEARCH. 4504 03:04:13,434 --> 03:04:14,401 SINCE THE INITIATIVE, WE'VE ALSO 4505 03:04:14,401 --> 03:04:15,836 DONE A NUMBER OF OTHER THINGS. 4506 03:04:15,836 --> 03:04:18,338 SO ONE OF THE THINGS THAT I 4507 03:04:18,338 --> 03:04:19,673 THINK IS IMPORTANT TO MENTION AT 4508 03:04:19,673 --> 03:04:22,276 THIS JUNCTURE IS THE FACT THAT 4509 03:04:22,276 --> 03:04:24,712 WE ENGAGE OVER THE MONTHS OF 4510 03:04:24,712 --> 03:04:27,648 NOVEMBER, DECEMBER, JANUARY, AND 4511 03:04:27,648 --> 03:04:29,950 STILL INTO MARCH, A LARGE NUMBER 4512 03:04:29,950 --> 03:04:31,819 OF LISTENING SESSIONS. 4513 03:04:31,819 --> 03:04:32,986 THEY TRULY WERE LISTENING 4514 03:04:32,986 --> 03:04:36,290 SESSIONS OF ALL SORTS OF 4515 03:04:36,290 --> 03:04:36,790 STAKEHOLDERS. 4516 03:04:36,790 --> 03:04:37,491 THAT INCLUDED EVERY DIMENSION 4517 03:04:37,491 --> 03:04:39,560 THAT WE COULD THINK OF FROM 4518 03:04:39,560 --> 03:04:41,528 PATIENTS TO HEALTH CARE 4519 03:04:41,528 --> 03:04:44,298 PROVIDERS TO RESEARCHERS, TO 4520 03:04:44,298 --> 03:04:46,600 EXPERTS IN VARIOUS FIELDS, TO 4521 03:04:46,600 --> 03:04:49,103 ADVOCACY GROUPS, TO PEOPLE WHO 4522 03:04:49,103 --> 03:04:50,404 REPRESENTED SPECIFIC PARTS OF 4523 03:04:50,404 --> 03:04:54,041 THE SECTOR THAT WE'RE INTERESTED 4524 03:04:54,041 --> 03:04:57,544 IN, AND WE HEARD FROM A LARGE 4525 03:04:57,544 --> 03:04:59,513 VARIETY OF PEOPLE, ESPECIALLY 4526 03:04:59,513 --> 03:05:02,349 RESEARCH EXPERTS, ACROSS THE 4527 03:05:02,349 --> 03:05:04,318 NATION IN VARIOUS SPECIALTIES 4528 03:05:04,318 --> 03:05:05,619 ABOUT WHAT'S NEEDED. 4529 03:05:05,619 --> 03:05:09,123 AND SINCE THE INITIATIVE BEGAN, 4530 03:05:09,123 --> 03:05:11,225 IT WAS REALLY DR. BIDEN, DR. 4531 03:05:11,225 --> 03:05:15,262 JILL BIDEN, WHO IS LEADING THE 4532 03:05:15,262 --> 03:05:15,429 WAY. 4533 03:05:15,429 --> 03:05:16,797 AND IT'S USEFUL I THINK FOR US 4534 03:05:16,797 --> 03:05:18,532 TO KNOW IN THIS DAY AND AGE THAT 4535 03:05:18,532 --> 03:05:21,802 THE TRUTH OF THE MATTER IS DR. 4536 03:05:21,802 --> 03:05:23,470 BIDEN IS VERY DEDICATED TO THIS 4537 03:05:23,470 --> 03:05:25,305 AND WANTED TO LEARN MORE ABOUT 4538 03:05:25,305 --> 03:05:25,572 IT. 4539 03:05:25,572 --> 03:05:27,741 SO WE TRAVELED, WE TRAVELED TO 4540 03:05:27,741 --> 03:05:29,042 DIFFERENT LABORATORIES AND 4541 03:05:29,042 --> 03:05:31,445 PLACES AROUND THE COUNTRY, FROM 4542 03:05:31,445 --> 03:05:34,181 CALIFORNIA TO ILLINOIS, TO 4543 03:05:34,181 --> 03:05:36,383 GEORGIA, TO MASSACHUSETTS, 4544 03:05:36,383 --> 03:05:38,452 TOURING RESEARCH LABORATORIES, 4545 03:05:38,452 --> 03:05:40,320 ENABLING THESE RESEARCHERS TO 4546 03:05:40,320 --> 03:05:42,923 TALK WITH HER AND US ABOUT THE 4547 03:05:42,923 --> 03:05:45,459 QUESTIONS THEY ARE TRYING TO 4548 03:05:45,459 --> 03:05:47,861 ANSWER, WHY THEY ARE IMPORTANT, 4549 03:05:47,861 --> 03:05:51,031 AND WHY RESEARCH CAN DO THAT. 4550 03:05:51,031 --> 03:05:54,501 SO THAT SHE HAD A FUNDAMENTAL 4551 03:05:54,501 --> 03:05:55,702 UNDERSTANDING WHEN SHE STANDS UP 4552 03:05:55,702 --> 03:05:58,005 AND MAKES REMARKS ABOUT THE 4553 03:05:58,005 --> 03:06:00,007 IMPORTANCE OF THIS. 4554 03:06:00,007 --> 03:06:03,610 SO, WE HAD LAB TOURS, WE HAD 4555 03:06:03,610 --> 03:06:04,478 LISTENING SESSIONS. 4556 03:06:04,478 --> 03:06:06,780 AND HEARD FIRST HAND ABOUT 4557 03:06:06,780 --> 03:06:08,949 HEALTH CONCERNS WOMEN FACE AND 4558 03:06:08,949 --> 03:06:09,817 CUTTING-EDGE RESEARCH THAT'S 4559 03:06:09,817 --> 03:06:12,886 POSSIBLE WHEN WE INVEST IN 4560 03:06:12,886 --> 03:06:13,554 WOMEN'S HEALTH. 4561 03:06:13,554 --> 03:06:15,422 AND ABOUT WHAT WE MUST DO TO 4562 03:06:15,422 --> 03:06:17,491 SUPPORT THE BREAKTHROUGHS WE 4563 03:06:17,491 --> 03:06:18,592 NEED IN CRITICAL AREAS, FOR 4564 03:06:18,592 --> 03:06:20,327 EXAMPLE IN WOMEN'S HEART HEALTH, 4565 03:06:20,327 --> 03:06:23,530 GREATEST CAUSE OF DEATH FOR 4566 03:06:23,530 --> 03:06:25,299 WOMEN IN OUR NATION. 4567 03:06:25,299 --> 03:06:27,267 THROUGHOUT ALL THESE EXPERIENCES 4568 03:06:27,267 --> 03:06:29,770 AND DISCUSSIONS, WE LISTENED FOR 4569 03:06:29,770 --> 03:06:31,538 OPPORTUNITIES FOR CHANGE THAT 4570 03:06:31,538 --> 03:06:33,807 WOULD CHANGE WOMEN'S HEALTH 4571 03:06:33,807 --> 03:06:36,009 RESEARCH. 4572 03:06:36,009 --> 03:06:36,677 AND AMONG THESE RECURRING THEMES 4573 03:06:36,677 --> 03:06:38,745 I'D LIKE TO SHOW YOU A FEW. 4574 03:06:38,745 --> 03:06:41,181 AND THESE WERE REALLY THE MOST 4575 03:06:41,181 --> 03:06:43,684 PREVALENT, PROMINENT THEMES. 4576 03:06:43,684 --> 03:06:47,621 FIRST, THE IMPORTANCE OF 4577 03:06:47,621 --> 03:06:50,123 ADDRESSING HEALTH DISPARITIES, 4578 03:06:50,123 --> 03:06:51,325 INCLUDING IN CLINICAL TRIAL 4579 03:06:51,325 --> 03:06:53,727 PARTICIPATION, AND ONE OF THE 4580 03:06:53,727 --> 03:06:57,030 THINGS WE LEARNED IN TERMS OF 4581 03:06:57,030 --> 03:06:57,631 RETENTION. 4582 03:06:57,631 --> 03:07:00,434 THAT IS AN ENORMOUS PROBLEM FOR 4583 03:07:00,434 --> 03:07:04,605 US TO FACE. 4584 03:07:04,605 --> 03:07:05,138 SECONDLY, INCREASING 4585 03:07:05,138 --> 03:07:05,539 INTERDISCIPLINARY 4586 03:07:05,539 --> 03:07:06,173 COLLABORATIONS, SO YOU'VE HEARD 4587 03:07:06,173 --> 03:07:07,875 THAT MANY OF US HAVE BEEN 4588 03:07:07,875 --> 03:07:08,609 THINKING ABOUT INTERDISCIPLINARY 4589 03:07:08,609 --> 03:07:10,510 WORK FOR A LONG TIME, 4590 03:07:10,510 --> 03:07:12,512 FORTUNATELY NIH IS THINKING 4591 03:07:12,512 --> 03:07:14,982 ABOUT IT IN A PRIMARY WAY. 4592 03:07:14,982 --> 03:07:16,083 THERE'S A GREAT MOVE IN THAT 4593 03:07:16,083 --> 03:07:16,683 DIRECTION. 4594 03:07:16,683 --> 03:07:21,421 WE HAVE TO MOVE FASTER IN THAT 4595 03:07:21,421 --> 03:07:21,688 DIRECTION. 4596 03:07:21,688 --> 03:07:22,522 SO, INCREASING INTERDISCIPLINARY 4597 03:07:22,522 --> 03:07:23,857 COLLABORATIONS REALLY TO HELP US 4598 03:07:23,857 --> 03:07:24,858 ANSWER THE COMPLEX QUESTIONS 4599 03:07:24,858 --> 03:07:27,494 THAT COME UP IN HEALTH AND 4600 03:07:27,494 --> 03:07:28,795 PARTICULARLY IN WOMEN'S HEALTH, 4601 03:07:28,795 --> 03:07:32,266 A LA CHRONIC DISORDERS, A LA 4602 03:07:32,266 --> 03:07:34,368 COMORBID DISORDERS. 4603 03:07:34,368 --> 03:07:36,470 AND THEN FINALLY TRANSLATING 4604 03:07:36,470 --> 03:07:38,405 CRITICAL RESEARCH FINDINGS INTO 4605 03:07:38,405 --> 03:07:40,707 THE MARKETPLACE IN A MUCH MORE 4606 03:07:40,707 --> 03:07:41,475 TIMELY WAY. 4607 03:07:41,475 --> 03:07:47,814 I HEARD THAT COME UP TOO IN SOME 4608 03:07:47,814 --> 03:07:50,450 OF THE DISCUSSIONS TODAY. 4609 03:07:50,450 --> 03:07:53,620 SO, THIS IS AN EXAMPLE OF HOW WE 4610 03:07:53,620 --> 03:07:55,155 HAVE TAKEN LISTENING AND WE'VE 4611 03:07:55,155 --> 03:07:57,791 TRIED TO APPLY IT. 4612 03:07:57,791 --> 03:08:00,294 WE WORKED WITH ARPA-H AND IN 4613 03:08:00,294 --> 03:08:03,363 MARCH OF 2024 THE FIRST LADY 4614 03:08:03,363 --> 03:08:05,132 TRAVELED TO CAMBRIDGE TO 4615 03:08:05,132 --> 03:08:06,967 ANNOUNCE ARPA-H'S FIRST EVER 4616 03:08:06,967 --> 03:08:07,868 SPRINT FOR WOMEN'S HEALTH. 4617 03:08:07,868 --> 03:08:10,704 FOR THOSE THAT MAY NOT BE 4618 03:08:10,704 --> 03:08:13,874 FAMILIAR WITH ARPA-H, IT'S 4619 03:08:13,874 --> 03:08:16,510 ADVANCED RESEARCH PROJECTS 4620 03:08:16,510 --> 03:08:17,911 AGENCY FOR HEALTH. 4621 03:08:17,911 --> 03:08:19,346 AND THE INITIAL COMMITMENT THAT 4622 03:08:19,346 --> 03:08:22,215 THEY HAVE MADE FOR THIS CURRENT 4623 03:08:22,215 --> 03:08:23,517 YEAR IS $100 MILLION. 4624 03:08:23,517 --> 03:08:26,787 PEOPLE ARE NOW APPLYING FOR THAT 4625 03:08:26,787 --> 03:08:29,756 MONEY, ACTIVELY, AND WE ARE VERY 4626 03:08:29,756 --> 03:08:30,824 EXCITED ABOUT THE POSSIBILITIES 4627 03:08:30,824 --> 03:08:33,327 THAT MIGHT COME FROM THAT 4628 03:08:33,327 --> 03:08:35,529 BECAUSE WHAT THEIR SPECIALTY IS, 4629 03:08:35,529 --> 03:08:37,297 IS REALLY TO IDENTIFY 4630 03:08:37,297 --> 03:08:38,598 INDIVIDUALS, GROUP THEM TOGETHER 4631 03:08:38,598 --> 03:08:41,234 TO SOLVE A PARTICULAR PROBLEM, 4632 03:08:41,234 --> 03:08:44,871 AND THEN TAKE THAT SOLUTION TO 4633 03:08:44,871 --> 03:08:45,539 THE MARKETPLACE. 4634 03:08:45,539 --> 03:08:47,307 WHICH IS SOMETHING THAT'S REALLY 4635 03:08:47,307 --> 03:08:55,615 NOT DONE SUFFICIENTLY IN OUR 4636 03:08:55,615 --> 03:08:56,049 VIEW. 4637 03:08:56,049 --> 03:08:57,684 UNDERRER THE LEADSHIP THE SPRINT 4638 03:08:57,684 --> 03:08:59,853 TOOL WILL ACCELERATE DISCOVERIES 4639 03:08:59,853 --> 03:09:04,691 FROM EARLY STAGE PROOFS OF 4640 03:09:04,691 --> 03:09:10,263 CONCEPT TO PRODUCTS READY TO BE 4641 03:09:10,263 --> 03:09:11,198 COMMERCIALIZED, AS INDICATED 4642 03:09:11,198 --> 03:09:12,766 THEY WOULD PLAN TO SUPPORT, THEY 4643 03:09:12,766 --> 03:09:13,967 ARE AWARE OF CHALLENGES MANY 4644 03:09:13,967 --> 03:09:14,434 WOMEN FACE. 4645 03:09:14,434 --> 03:09:17,604 I WANT TO READ YOU A QUOTE FROM 4646 03:09:17,604 --> 03:09:18,839 THEIR WORK. 4647 03:09:18,839 --> 03:09:20,007 ALTHOUGH TECHNOLOGY IS CAPABLE 4648 03:09:20,007 --> 03:09:21,742 OF DIAGNOSES AND POSSIBLY 4649 03:09:21,742 --> 03:09:23,010 TREATING DISEASES ACROSS ALL 4650 03:09:23,010 --> 03:09:27,114 AGES AND STAGES OF A WOMAN'S 4651 03:09:27,114 --> 03:09:29,216 LIFE, ARE INCREASINGLY POSSIBLE, 4652 03:09:29,216 --> 03:09:31,485 VERY FEW ARE AFFORDABLE. 4653 03:09:31,485 --> 03:09:33,687 AND/OR CURRENTLY AVAILABLE IN 4654 03:09:33,687 --> 03:09:37,624 THE MARKETPLACE, OR ARE EASY TO 4655 03:09:37,624 --> 03:09:37,791 USE. 4656 03:09:37,791 --> 03:09:40,027 SO, AGAIN, OUT OF THE LISTENING 4657 03:09:40,027 --> 03:09:41,661 SESSIONS WE'RE TRYING TO PAY 4658 03:09:41,661 --> 03:09:43,864 ATTENTION TO WHAT PEOPLE NEED TO 4659 03:09:43,864 --> 03:09:46,700 WHAT WOMEN NEED, AND ARPA-H 4660 03:09:46,700 --> 03:09:48,568 WANTS TO CHANGE THAT LANDSCAPE. 4661 03:09:48,568 --> 03:09:52,372 AND THIS IS JUST THE BEGINNING. 4662 03:09:52,372 --> 03:09:54,374 SO THIS IS THE PRESIDENT OF 4663 03:09:54,374 --> 03:09:56,676 COURSE IN THE STATE OF THE UNION 4664 03:09:56,676 --> 03:10:00,680 IN WHICH HE ASKED FOR CONGRESS 4665 03:10:00,680 --> 03:10:03,016 TO MAKE A BOLD TRANSFORMATIVE 4666 03:10:03,016 --> 03:10:06,720 INVESTMENT IN WOMEN'S HEALTH 4667 03:10:06,720 --> 03:10:07,721 RESEARCH OF $12 MILLION. 4668 03:10:07,721 --> 03:10:10,891 YOU MIGHT ASK, WHAT WOULD WE USE 4669 03:10:10,891 --> 03:10:12,426 THAT MONEY FOR? 4670 03:10:12,426 --> 03:10:16,063 AND SO, THERE WERE TWO PRIMARY 4671 03:10:16,063 --> 03:10:19,099 GOALS FOR THAT PARTICULAR ASK. 4672 03:10:19,099 --> 03:10:21,668 FIRST, A CENTRAL FUND FOR 4673 03:10:21,668 --> 03:10:26,740 WOMEN'S HEALTH AT THE NIH TO 4674 03:10:26,740 --> 03:10:27,407 ADVANCE INTERDISCIPLINARY 4675 03:10:27,407 --> 03:10:28,942 SCIENCE. 4676 03:10:28,942 --> 03:10:32,446 AND WHAT WE HAVE IN MIND IS THE 4677 03:10:32,446 --> 03:10:35,916 NEED TO SPUR INTERDISCIPLINARY 4678 03:10:35,916 --> 03:10:37,818 SCIENCE SPECIFICALLY ON WOMEN'S 4679 03:10:37,818 --> 03:10:38,852 HEALTH RESEARCH. 4680 03:10:38,852 --> 03:10:42,189 THIS WOULD SIT WITHIN THE NIH 4681 03:10:42,189 --> 03:10:44,157 BUDGET, AND IT WOULD INVITE 4682 03:10:44,157 --> 03:10:46,693 DIFFERENT AREAS OF SCIENCE TO 4683 03:10:46,693 --> 03:10:49,196 WORK TOGETHER TO ANSWER COMPLEX 4684 03:10:49,196 --> 03:10:50,297 QUESTIONS REQUIRING MULTIPLE 4685 03:10:50,297 --> 03:10:52,132 DISCIPLINES AND LEVELS OF 4686 03:10:52,132 --> 03:10:52,432 EXAMINATION. 4687 03:10:52,432 --> 03:10:54,334 AND THIS INCLUDES AREAS OF 4688 03:10:54,334 --> 03:10:56,436 RESEARCH THAT CUT ACROSS HEALTH 4689 03:10:56,436 --> 03:10:57,737 AREAS THAT DON'T EXPLICITLY FIT 4690 03:10:57,737 --> 03:11:02,109 INTO THE MANDATES OF INSTITUTES 4691 03:11:02,109 --> 03:11:04,744 AND CENTERS. 4692 03:11:04,744 --> 03:11:06,813 IN ADDITION, THIS MONEY WOULD 4693 03:11:06,813 --> 03:11:08,448 CREATE A NEW NATIONWIDE NETWORK 4694 03:11:08,448 --> 03:11:10,550 OF RESEARCH CENTERS OF 4695 03:11:10,550 --> 03:11:12,052 EXCELLENCE AND INNOVATION THAT 4696 03:11:12,052 --> 03:11:14,921 WOULD PIVOT OFF THE EXISTING 4697 03:11:14,921 --> 03:11:18,191 SUCCESS OF THE SCORES. 4698 03:11:18,191 --> 03:11:20,060 AND INCLUDE INNOVATION IN A NEW 4699 03:11:20,060 --> 03:11:24,764 WAY THAT SPURS TRANSLATION OF 4700 03:11:24,764 --> 03:11:25,398 RESEARCH. 4701 03:11:25,398 --> 03:11:27,400 AS WE WORK WITH CONGRESS NOW, 4702 03:11:27,400 --> 03:11:30,770 OVER THE NEXT NUMBER OF MONTHS, 4703 03:11:30,770 --> 03:11:32,405 TO SECURE THESE INVESTMENTS, 4704 03:11:32,405 --> 03:11:35,175 WE'RE TAKING EXECUTIVE ACTION TO 4705 03:11:35,175 --> 03:11:36,143 ADVANCE WOMEN'S HEALTH RESEARCH. 4706 03:11:36,143 --> 03:11:40,113 AND WHAT I'M ABOUT TO SHOW YOU 4707 03:11:40,113 --> 03:11:43,250 ARE PIECES OF THE PUZZLE THAT 4708 03:11:43,250 --> 03:11:44,251 WE'RE PUTTING TOGETHER HOW TO 4709 03:11:44,251 --> 03:11:45,685 MAKE CHANGE AND I'M GOING TO 4710 03:11:45,685 --> 03:11:47,587 GIVE SOME EXAMPLES OF WHAT THE 4711 03:11:47,587 --> 03:11:51,691 AGENCIES ARE GOING TO DO. 4712 03:11:51,691 --> 03:11:54,194 SO, FIRST OF ALL, AS THE 4713 03:11:54,194 --> 03:11:57,164 AGENCIES TAKE ACTION, THE NIH IS 4714 03:11:57,164 --> 03:11:58,465 LAUNCHING A NEW NIH-WIDE EFFORT 4715 03:11:58,465 --> 03:12:00,433 TO CLOSE GAPS IN WOMEN'S HEALTH 4716 03:12:00,433 --> 03:12:01,868 RESEARCH ACROSS THE LIFESPAN AND 4717 03:12:01,868 --> 03:12:04,905 THAT'S GOING TO BE SUPPORTED BY 4718 03:12:04,905 --> 03:12:08,441 $200 MILLION FROM NIH IN THIS 4719 03:12:08,441 --> 03:12:10,810 FISCAL YEAR COMING UP. 4720 03:12:10,810 --> 03:12:12,579 FY 25. 4721 03:12:12,579 --> 03:12:18,818 SO YOU HAVE TIME TO WRITE YOUR 4722 03:12:18,818 --> 03:12:19,119 APPLICATION. 4723 03:12:19,119 --> 03:12:22,756 AND IMPORTANTLY, THE NIH WILL 4724 03:12:22,756 --> 03:12:25,425 ALSO ESTABLISH AN INITIATIVE ON 4725 03:12:25,425 --> 03:12:28,328 BIOMARKER DISCOVERY AND I THINK, 4726 03:12:28,328 --> 03:12:31,164 AGAIN, MONICA -- DR. BERTAGNOLLI 4727 03:12:31,164 --> 03:12:35,001 ALLUDED TO THIS IN SOME WAYS. 4728 03:12:35,001 --> 03:12:37,537 AND WE THINK THIS IS REALLY 4729 03:12:37,537 --> 03:12:38,238 QUITE IMPORTANT. 4730 03:12:38,238 --> 03:12:39,706 WHAT I SKIPPED OVER AND I WANT 4731 03:12:39,706 --> 03:12:45,612 TO GO BACK TO THOUGH IS IN 4732 03:12:45,612 --> 03:12:48,515 ADDITION TO THE FY 25 BUDGET 4733 03:12:48,515 --> 03:12:53,253 REQUEST, THAT WOULD BE THE $12 4734 03:12:53,253 --> 03:12:54,254 BILLION, WE ALSO WOULD DOUBLE 4735 03:12:54,254 --> 03:12:55,889 THE CURRENT BUDGET FOR THE 4736 03:12:55,889 --> 03:12:58,491 OFFICE OF RESEARCH ON WOMEN'S 4737 03:12:58,491 --> 03:12:58,725 HEALTH. 4738 03:12:58,725 --> 03:13:00,627 BECAUSE THIS OFFICE PLAYS SUCH A 4739 03:13:00,627 --> 03:13:02,696 CRITICAL ROLE AND NEEDS TO HAVE 4740 03:13:02,696 --> 03:13:05,098 MORE SUPPORT IN THEIR EFFORTS. 4741 03:13:05,098 --> 03:13:07,601 AND THIS WOULD SUPPORT NEW AND 4742 03:13:07,601 --> 03:13:10,770 EXISTING EFFORTS THAT EMPHASIZE 4743 03:13:10,770 --> 03:13:13,607 WOMEN'S HEALTH RESEARCH. 4744 03:13:13,607 --> 03:13:18,979 SO, BACK TO THE NIH AND WHAT 4745 03:13:18,979 --> 03:13:20,280 ELSE THEY ARE DOING OUT OF 4746 03:13:20,280 --> 03:13:20,947 WONDERFUL RECOMMENDATIONS THEY 4747 03:13:20,947 --> 03:13:24,784 MADE TO US WILL ESTABLISH THIS 4748 03:13:24,784 --> 03:13:25,418 INITIATIVE ON BIOMARKER 4749 03:13:25,418 --> 03:13:27,754 DISCOVERY I BEGAN TO MENTION AND 4750 03:13:27,754 --> 03:13:30,824 THEY ARE GOING TO LAUNCH FIRST 4751 03:13:30,824 --> 03:13:33,226 EVER PATHWAY TO PREVENTION IN 4752 03:13:33,226 --> 03:13:37,797 MENOPAUSE AND TREATMENT OF 4753 03:13:37,797 --> 03:13:39,032 MENOPAUSAL SYMPTOMS AND KICKING 4754 03:13:39,032 --> 03:13:41,001 OFF AN EFFORT TO IDENTIFY NEW 4755 03:13:41,001 --> 03:13:41,801 COMMON DATA ELEMENTS RELATED TO 4756 03:13:41,801 --> 03:13:42,602 WOMEN'S HEALTH. 4757 03:13:42,602 --> 03:13:45,005 I THINK YOU HEARD ABOUT THAT AND 4758 03:13:45,005 --> 03:13:52,812 WE CAN TALK MORE ABOUT THAT AS 4759 03:13:52,812 --> 03:13:53,780 WELL. 4760 03:13:53,780 --> 03:13:58,051 SO, IMPORTANTLY, IF WE GO BEYOND 4761 03:13:58,051 --> 03:14:01,421 THE NIH, WE CAN LOOK AT A FEW 4762 03:14:01,421 --> 03:14:03,323 OTHER OPPORTUNITIES THAT 4763 03:14:03,323 --> 03:14:06,826 AGENCIES ARE TAKING ADVANTAGE 4764 03:14:06,826 --> 03:14:07,027 OF. 4765 03:14:07,027 --> 03:14:09,663 NATIONAL SCIENCE FOUNDATION, FOR 4766 03:14:09,663 --> 03:14:12,999 THE VERY FIRST TIME, IS BROADLY 4767 03:14:12,999 --> 03:14:15,835 CALLING FOR NOVEL AND 4768 03:14:15,835 --> 03:14:16,603 TRANSFORMATIVE RESEARCH FOCUSED 4769 03:14:16,603 --> 03:14:18,338 ENTIRELY ON WOMEN'S HEALTH 4770 03:14:18,338 --> 03:14:18,838 TOPICS. 4771 03:14:18,838 --> 03:14:21,741 THEY PUT OUT WHAT THEY CALL A 4772 03:14:21,741 --> 03:14:23,510 DEAR COLLEAGUE LETTER, SOUNDS SO 4773 03:14:23,510 --> 03:14:26,212 MUCH NICER THAN A REQUEST, RFA, 4774 03:14:26,212 --> 03:14:28,181 NOFO, BUT THAT'S WHAT THEY DO. 4775 03:14:28,181 --> 03:14:30,850 THEY ARE PUTTING ONE OUT 4776 03:14:30,850 --> 03:14:31,618 EXPLICITLY FOR WOMEN'S HEALTH 4777 03:14:31,618 --> 03:14:34,554 RESEARCH FOR THE FIRST TIME 4778 03:14:34,554 --> 03:14:35,722 EVER. 4779 03:14:35,722 --> 03:14:36,256 DEPARTMENT OF DEFENSE AND 4780 03:14:36,256 --> 03:14:37,057 DEPARTMENT OF VETERANS AFFAIRS 4781 03:14:37,057 --> 03:14:41,361 ARE LAUNCHING A NEW WOMEN'S 4782 03:14:41,361 --> 03:14:42,295 HEALTH RESEARCH COLLABORATIVE, 4783 03:14:42,295 --> 03:14:44,264 AND THAT'S DESIGNED TO IMPROVE 4784 03:14:44,264 --> 03:14:46,132 HEALTH OUTCOMES BOTH FOR 4785 03:14:46,132 --> 03:14:52,038 VETERANS AND FOR ACTIVE 4786 03:14:52,038 --> 03:14:52,372 SERVICEWOMEN. 4787 03:14:52,372 --> 03:14:56,276 THE CENTERS FOR MEDICARE AND 4788 03:14:56,276 --> 03:14:57,644 MEDICAID SERVICES, CMS, IS 4789 03:14:57,644 --> 03:15:01,448 TAKING STEPS TO ENSURE NEW 4790 03:15:01,448 --> 03:15:01,848 MEDICAL SERVICES. 4791 03:15:01,848 --> 03:15:05,618 AND THEY ARE GOING TO STRENGTHEN 4792 03:15:05,618 --> 03:15:08,154 THEIR REVIEW PROCESS IN THIS 4793 03:15:08,154 --> 03:15:09,789 ACTION, INCLUDING COVERAGE WITH 4794 03:15:09,789 --> 03:15:11,524 EVIDENCE DEVELOPMENT GUIDANCE TO 4795 03:15:11,524 --> 03:15:13,727 ENSURE THAT THE NEW MEDICAL 4796 03:15:13,727 --> 03:15:15,795 SERVICES AND TECHNOLOGIES THAT 4797 03:15:15,795 --> 03:15:18,531 ARE PUT FORWARD FOR USE IN CARE 4798 03:15:18,531 --> 03:15:22,369 OF WOMEN, THAT THEY WORK WELL 4799 03:15:22,369 --> 03:15:23,036 FOR WOMEN. 4800 03:15:23,036 --> 03:15:24,904 THIS WILL HELP ENSURE THAT 4801 03:15:24,904 --> 03:15:27,307 MEDICARE FUNDS ARE USED FOR 4802 03:15:27,307 --> 03:15:28,074 TREATMENTS WITH SUFFICIENT 4803 03:15:28,074 --> 03:15:30,143 DATABASE, TO SHOW THEY ACTUALLY 4804 03:15:30,143 --> 03:15:31,878 WORK IN WOMEN, WHO MAKE UP MORE 4805 03:15:31,878 --> 03:15:37,350 THAN HALF OF THE MEDICARE 4806 03:15:37,350 --> 03:15:37,817 POPULATION. 4807 03:15:37,817 --> 03:15:41,421 THE CENTERS FOR DISEASE CONTROL, 4808 03:15:41,421 --> 03:15:44,057 CDC, IS ALSO PARTICIPATING IN 4809 03:15:44,057 --> 03:15:44,824 THIS. 4810 03:15:44,824 --> 03:15:47,227 I DID DO IT RIGHT. 4811 03:15:47,227 --> 03:15:49,963 I MOVED IT BACK. 4812 03:15:49,963 --> 03:15:51,598 THE CDC IN COLLABORATION WITH 4813 03:15:51,598 --> 03:15:53,466 CDC FOUNDATION AND AMERICAN 4814 03:15:53,466 --> 03:15:54,801 BOARD OF OBSTETRICS AND 4815 03:15:54,801 --> 03:15:55,869 GYNECOLOGY IS EXPANDING TRAINING 4816 03:15:55,869 --> 03:15:58,071 IN WOMEN'S HEALTH RESEARCH AND 4817 03:15:58,071 --> 03:16:01,441 PUBLIC HEALTH SURVEILLANCE TO 4818 03:16:01,441 --> 03:16:04,644 OBSTETRICIAN GYNECOLOGISTS, 4819 03:16:04,644 --> 03:16:05,712 NURSES, ADVANCED PRACTICE 4820 03:16:05,712 --> 03:16:07,380 NURSES. 4821 03:16:07,380 --> 03:16:10,750 SO, HERE WE ARE NOW. 4822 03:16:10,750 --> 03:16:12,652 AND THIS IS THE SIGNING OF THE 4823 03:16:12,652 --> 03:16:14,254 EXECUTIVE ORDER THAT TOOK PLACE 4824 03:16:14,254 --> 03:16:19,492 ON MARCH 18 OF THIS YEAR. 4825 03:16:19,492 --> 03:16:24,431 AND THERE WAS JUST A TREMENDOUS 4826 03:16:24,431 --> 03:16:27,834 EXCITEMENT THAT DAY, AND I JUST 4827 03:16:27,834 --> 03:16:30,136 THINK IT'S REALLY EXTRAORDINARY 4828 03:16:30,136 --> 03:16:31,538 WHAT WE ALL EXPERIENCED WHO WERE 4829 03:16:31,538 --> 03:16:33,373 THERE THAT DAY AND SAW THE 4830 03:16:33,373 --> 03:16:36,242 OPPORTUNITIES THAT WERE IN FRONT 4831 03:16:36,242 --> 03:16:37,544 OF US. 4832 03:16:37,544 --> 03:16:39,179 AND THE EXECUTIVE ORDER OR HOW 4833 03:16:39,179 --> 03:16:43,917 WE OFTEN REFER TO IT AS THE 4834 03:16:43,917 --> 03:16:45,485 E.O., THE PRESIDENT ADDRESSED 4835 03:16:45,485 --> 03:16:47,854 THE NATION REALLY IN TERMS OF 4836 03:16:47,854 --> 03:16:49,389 THE NEED FOR FURTHER ACTION IN 4837 03:16:49,389 --> 03:16:50,590 REGARD TO WOMEN'S HEALTH 4838 03:16:50,590 --> 03:16:52,759 RESEARCH, AND THAT'S THE BASIS 4839 03:16:52,759 --> 03:16:54,194 OF THE EXECUTIVE ORDER. 4840 03:16:54,194 --> 03:16:55,728 IT DIRECTS THE MOST 4841 03:16:55,728 --> 03:16:58,665 COMPREHENSIVE SET OF EXECUTIVE 4842 03:16:58,665 --> 03:17:01,935 ACTIONS EVER TAKEN TO ADVANCE 4843 03:17:01,935 --> 03:17:03,703 WOMEN'S HEALTH RESEARCH. 4844 03:17:03,703 --> 03:17:06,473 AND IN THIS, THE PRESIDENT 4845 03:17:06,473 --> 03:17:07,474 REITERATES THAT EXISTING, QUOTE, 4846 03:17:07,474 --> 03:17:08,975 RESEARCH GAPS MEAN THAT WE KNOW 4847 03:17:08,975 --> 03:17:11,611 FAR TOO LITTLE ABOUT WOMEN'S 4848 03:17:11,611 --> 03:17:13,713 HEALTH ACROSS WOMEN'S LIFESPANS 4849 03:17:13,713 --> 03:17:16,349 AND THOSE GAPS ARE EVEN MORE 4850 03:17:16,349 --> 03:17:18,518 PROMINENT FOR WOMEN OF COLOR, 4851 03:17:18,518 --> 03:17:21,554 OLDER WOMEN, WOMEN WITH 4852 03:17:21,554 --> 03:17:22,355 DISABILITIES. 4853 03:17:22,355 --> 03:17:25,191 AND WE HAVE TO START PAYING 4854 03:17:25,191 --> 03:17:32,298 DIRECT ATTENTION TO THIS TYPE OF 4855 03:17:32,298 --> 03:17:32,765 IMPORTANT PRONOUNCE. 4856 03:17:32,765 --> 03:17:33,099 . 4857 03:17:33,099 --> 03:17:36,769 THE PRESIDENT IS DIRECTING 4858 03:17:36,769 --> 03:17:42,609 MEMBERS OF THE INITIATIVE, THE 4859 03:17:42,609 --> 03:17:43,810 AGENCIES, INCLUDING THESE 4860 03:17:43,810 --> 03:17:46,212 FEDERAL DEPARTMENTS AND OTHERS 4861 03:17:46,212 --> 03:17:48,481 TO DO SEVERAL THINGS. 4862 03:17:48,481 --> 03:17:50,583 FIRST, TO INTEGRATE WOMEN'S 4863 03:17:50,583 --> 03:17:53,319 HEALTH ACROSS THE FEDERAL 4864 03:17:53,319 --> 03:17:54,287 RESEARCH PORTFOLIO. 4865 03:17:54,287 --> 03:17:56,823 SO, INTEGRATING THE BROAD SCOPE 4866 03:17:56,823 --> 03:17:58,224 OF HEALTH CONDITIONS AFFECTING 4867 03:17:58,224 --> 03:17:59,559 WOMEN ACROSS THE FEDERAL 4868 03:17:59,559 --> 03:18:01,427 RESEARCH PORTFOLIO IS GOING TO 4869 03:18:01,427 --> 03:18:04,497 BE DONE BY STRENGTHENING 4870 03:18:04,497 --> 03:18:05,899 RESEARCH AND DATA STANDARDS THAT 4871 03:18:05,899 --> 03:18:07,534 ARE RELATED TO WOMEN'S HEALTH 4872 03:18:07,534 --> 03:18:13,573 WITH THE GOAL OF ENSURING FUNDED 4873 03:18:13,573 --> 03:18:14,240 RESEARCH CONSIDERS WOMEN'S 4874 03:18:14,240 --> 03:18:17,744 HEALTH IN THE DEVELOPMENT OF 4875 03:18:17,744 --> 03:18:22,749 STUDY DESIGN AND IN DATA 4876 03:18:22,749 --> 03:18:26,052 COLLECTION AND ANALYSIS. 4877 03:18:26,052 --> 03:18:27,253 PRIORITIZING INVESTMENTS IN 4878 03:18:27,253 --> 03:18:28,888 WOMEN'S HEALTH RESEARCH. 4879 03:18:28,888 --> 03:18:32,759 THIS WILL FOCUS ON DRIVING 4880 03:18:32,759 --> 03:18:33,493 INNOVATION, INCLUDING THROUGH 4881 03:18:33,493 --> 03:18:36,229 ENTITIES LIKE ARPA-H, AND THE 4882 03:18:36,229 --> 03:18:40,500 SMALL BUSINESS INNOVATION 4883 03:18:40,500 --> 03:18:42,902 RESEARCH PROGRAM, WHILE 4884 03:18:42,902 --> 03:18:43,403 PROMOTING COLLABORATIVE 4885 03:18:43,403 --> 03:18:44,037 INTERDISCIPLINARY SCIENCE, 4886 03:18:44,037 --> 03:18:45,538 ADDRESSING HEALTH DISPARITIES 4887 03:18:45,538 --> 03:18:46,873 AND INEQUITIES AFFECTING WOMEN 4888 03:18:46,873 --> 03:18:49,842 AND SUPPORTS TRANSLATION OF 4889 03:18:49,842 --> 03:18:54,113 FINDINGS INTO IMPROVED HEALTH 4890 03:18:54,113 --> 03:18:54,380 OUTCOMES. 4891 03:18:54,380 --> 03:18:59,252 ALSO TO GALVANIZE RESEARCH ON 4892 03:18:59,252 --> 03:19:02,555 MID-LIFE HEALTH BY LAUNCHING A 4893 03:19:02,555 --> 03:19:04,857 COMPREHENSIVE RESEARCH AGENDA. 4894 03:19:04,857 --> 03:19:07,393 I THANK DR. BERTAGNOLLI FOR 4895 03:19:07,393 --> 03:19:08,461 MENTIONING MID-LIFE HEALTH, 4896 03:19:08,461 --> 03:19:09,996 WE'RE CONCERNED ABOUT DISORDERS 4897 03:19:09,996 --> 03:19:13,933 AND CONDITIONS THAT OFTEN OCCUR 4898 03:19:13,933 --> 03:19:16,035 IN MID-LIFE, INCLUDING SYMPTOMS 4899 03:19:16,035 --> 03:19:18,104 OF MENOPAUSE BUT INCLUDING AS 4900 03:19:18,104 --> 03:19:19,872 WELL INCREASED RISK AFTER 4901 03:19:19,872 --> 03:19:21,507 MENOPAUSE FOR HEART ATTACK, 4902 03:19:21,507 --> 03:19:24,611 ALZHEIMER'S DISEASE, 4903 03:19:24,611 --> 03:19:26,312 OSTEOPOROSIS AS EXAMPLES. 4904 03:19:26,312 --> 03:19:27,513 AND FINALLY TO ASSESS UNMET 4905 03:19:27,513 --> 03:19:30,283 NEEDS TO SUPPORT WOMEN'S HEALTH 4906 03:19:30,283 --> 03:19:30,683 RESEARCH. 4907 03:19:30,683 --> 03:19:32,719 AND WE DID THAT BY ASSESSING 4908 03:19:32,719 --> 03:19:33,519 GAPS IN FEDERAL FUNDING. 4909 03:19:33,519 --> 03:19:35,221 THIS IS GOING TO BE DONE BY 4910 03:19:35,221 --> 03:19:38,491 OFFICE OF MANAGEMENT AND BUDGET, 4911 03:19:38,491 --> 03:19:40,593 OMB. 4912 03:19:40,593 --> 03:19:41,761 AND GENDER POLICY COUNCIL. 4913 03:19:41,761 --> 03:19:43,196 THEY WILL BE IDENTIFYING CHANGES 4914 03:19:43,196 --> 03:19:44,297 PEOPLE ARE MAKING WITHIN 4915 03:19:44,297 --> 03:19:45,598 AGENCIES WITH REGARD TO WOMEN'S 4916 03:19:45,598 --> 03:19:51,070 HEALTH RESEARCH ON AN ANNUAL 4917 03:19:51,070 --> 03:19:51,471 BASIS. 4918 03:19:51,471 --> 03:19:53,806 ON THAT NOTE, AND I WANT TO TAKE 4919 03:19:53,806 --> 03:19:56,776 A STEP BACK AND TO SPEAK TO HOW 4920 03:19:56,776 --> 03:19:58,411 MEANINGFUL THIS WORK AND THE 4921 03:19:58,411 --> 03:19:59,412 FIRST LADY'S LEADERSHIP IS TO 4922 03:19:59,412 --> 03:20:03,116 THE FIELD OF WOMEN'S HEALTH 4923 03:20:03,116 --> 03:20:03,483 RESEARCH. 4924 03:20:03,483 --> 03:20:05,318 AS A CLINICIAN AND RESEARCHER, 4925 03:20:05,318 --> 03:20:08,388 AND THE FOUNDER AND DIRECTOR OF 4926 03:20:08,388 --> 03:20:10,256 A WOMEN'S HEALTH RESEARCH CENTER 4927 03:20:10,256 --> 03:20:12,325 AT YALE UNIVERSITY SCHOOL OF 4928 03:20:12,325 --> 03:20:16,229 MEDICINE, MY LIFE'S WORK REALLY 4929 03:20:16,229 --> 03:20:19,098 HAS BEEN DEDICATED TO WORKING ON 4930 03:20:19,098 --> 03:20:22,035 THE LARGE ISSUE OF IMPROVING THE 4931 03:20:22,035 --> 03:20:23,369 HEALTH OF WOMEN OVER TIME AND AS 4932 03:20:23,369 --> 03:20:25,972 I SAID EARLIER TO DID THAT IN 4933 03:20:25,972 --> 03:20:28,708 CONDITIONS THAT UNIQUELY AFFECT 4934 03:20:28,708 --> 03:20:31,044 WOMEN MORE PROMINENTLY OR AFFECT 4935 03:20:31,044 --> 03:20:31,878 WOMEN DIFFERENTLY. 4936 03:20:31,878 --> 03:20:34,080 AND IT IS MY CURRENT EXPERIENCE 4937 03:20:34,080 --> 03:20:37,817 THAT NEVER BEFORE HAS THERE BEEN 4938 03:20:37,817 --> 03:20:39,218 SUCH A COMPREHENSIVE EFFORT FROM 4939 03:20:39,218 --> 03:20:41,521 THE FEDERAL GOVERNMENT TO SPUR 4940 03:20:41,521 --> 03:20:45,358 INNOVATION IN WOMEN'S HEALTH, 4941 03:20:45,358 --> 03:20:48,094 RESEARCH, AND RELEVANT FEDERALLY 4942 03:20:48,094 --> 03:20:51,264 FUNDED HEALTH RESEARCH WORKING 4943 03:20:51,264 --> 03:20:54,200 HARDER FOR WOMEN. 4944 03:20:54,200 --> 03:20:56,502 THIS IS A HUGE OPPORTUNITY FOR 4945 03:20:56,502 --> 03:20:57,804 TRANSFORMATIVE CHANGE THAT CAN 4946 03:20:57,804 --> 03:21:01,140 IMPROVE THE HEALTH AND LIVES OF 4947 03:21:01,140 --> 03:21:03,209 WOMEN ACROSS THIS COUNTRY. 4948 03:21:03,209 --> 03:21:04,811 AND TO FULLY REALIZE THIS 4949 03:21:04,811 --> 03:21:07,013 OPPORTUNITY WE NEED TO WORK 4950 03:21:07,013 --> 03:21:08,381 TOGETHER ACROSS SECTORS AND 4951 03:21:08,381 --> 03:21:10,950 INDUSTRIES TO ENSURE ALL OF US, 4952 03:21:10,950 --> 03:21:13,586 GOVERNMENT, RESEARCH CENTERS, 4953 03:21:13,586 --> 03:21:14,721 ADVOCACY ORGANIZATIONS, 4954 03:21:14,721 --> 03:21:15,354 PHILANTHROPY AND PRIVATE SECTOR, 4955 03:21:15,354 --> 03:21:17,657 ARE DOING EVERYTHING WE CAN TO 4956 03:21:17,657 --> 03:21:19,926 CLOSE RESEARCH GAPS IN WOMEN'S 4957 03:21:19,926 --> 03:21:20,159 HEALTH. 4958 03:21:20,159 --> 03:21:22,028 THANKS TO THE FIRST LADY'S 4959 03:21:22,028 --> 03:21:23,896 LEADERSHIP, THE INITIATIVE WILL 4960 03:21:23,896 --> 03:21:25,098 CONTINUE TAKING ACTION TO 4961 03:21:25,098 --> 03:21:25,865 ADVANCE WOMEN'S HEALTH RESEARCH 4962 03:21:25,865 --> 03:21:28,034 SO WOMEN GET THE ANSWERS THEY 4963 03:21:28,034 --> 03:21:31,537 NEED WHEN IT COMES TO THEIR 4964 03:21:31,537 --> 03:21:32,105 HEALTH. 4965 03:21:32,105 --> 03:21:35,842 AND WITH THAT, I THANK YOU ALL 4966 03:21:35,842 --> 03:21:36,809 FOR YOUR TIME AND ATTENTION. 4967 03:21:36,809 --> 03:21:39,312 AND MOST OF ALL FOR YOUR CARING 4968 03:21:39,312 --> 03:21:43,282 ABOUT THE HEALTH OF WOMEN. 4969 03:21:43,282 --> 03:21:48,821 THANK YOU. 4970 03:21:48,821 --> 03:21:52,658 >> THAT THANK YOU FOR OUTLINING 4971 03:21:52,658 --> 03:21:53,559 THAT PATH FROM THE BEGINNING OF 4972 03:21:53,559 --> 03:21:57,363 THE SIGN OF THE PRESIDENTIAL 4973 03:21:57,363 --> 03:22:01,400 MEMO AND THAT 45-DAY SPRINT TO 4974 03:22:01,400 --> 03:22:02,635 COMMITMENT TO THE EXECUTIVE 4975 03:22:02,635 --> 03:22:06,005 AGENCIES THAT WE WOULD MAKE FOR 4976 03:22:06,005 --> 03:22:07,006 RECOMMENDATIONS TO THE ACTUAL 4977 03:22:07,006 --> 03:22:09,742 SIGNING OF THE EXECUTIVE ORDER. 4978 03:22:09,742 --> 03:22:11,878 >> I MIGHT INTERJECT, DR. 4979 03:22:11,878 --> 03:22:15,248 CLAYTON, THAT THE 45 DAYS WAS UP 4980 03:22:15,248 --> 03:22:16,349 ON DECEMBER 28. 4981 03:22:16,349 --> 03:22:18,351 WE DIDN'T MAKE A LOT OF FRIENDS 4982 03:22:18,351 --> 03:22:20,019 WITH THE AGENCIES HAVING THAT AS 4983 03:22:20,019 --> 03:22:21,654 THE DEADLINE, BUT THEY DID IT. 4984 03:22:21,654 --> 03:22:23,523 THEY WORKED WITH US. 4985 03:22:23,523 --> 03:22:26,259 WE WERE VERY PLEASED TO DO SO. 4986 03:22:26,259 --> 03:22:27,360 WE FOUND GREAT INTEREST AND 4987 03:22:27,360 --> 03:22:29,996 GREAT EXCITEMENT ON THE PART OF 4988 03:22:29,996 --> 03:22:32,064 THE AGENCIES. 4989 03:22:32,064 --> 03:22:33,199 AND WE ORGANIZED THAT MATERIAL 4990 03:22:33,199 --> 03:22:37,236 AND BRIEFED THE FIRST LADY ON 4991 03:22:37,236 --> 03:22:38,437 DECEMBER 29. 4992 03:22:38,437 --> 03:22:40,606 >> I KNOW HOW MUCH YOU RECEIVED 4993 03:22:40,606 --> 03:22:41,240 AT LEAST FROM THE DEPARTMENT OF 4994 03:22:41,240 --> 03:22:43,576 HEALTH AND HUMAN SERVICES, I CAN 4995 03:22:43,576 --> 03:22:45,411 NOT IMAGINE FROM ALL THE OTHER 4996 03:22:45,411 --> 03:22:46,512 DEPARTMENTS AND AGENCIES HOW 4997 03:22:46,512 --> 03:22:47,280 MUCH INFORMATION TO SYNTHESIZE 4998 03:22:47,280 --> 03:22:49,482 BUT I THINK THAT SPEAKS TO THE 4999 03:22:49,482 --> 03:22:51,017 COMMITMENT AS YOU SAID OF THE 5000 03:22:51,017 --> 03:22:52,685 FIRST LADY AND THE 5001 03:22:52,685 --> 03:22:55,188 ADMINISTRATION TO MOVING THIS 5002 03:22:55,188 --> 03:22:56,055 FORWARD. 5003 03:22:56,055 --> 03:22:59,559 I DO WONDER HOW RESEARCHERS AND 5004 03:22:59,559 --> 03:23:01,327 THE SCIENTIFIC COMMUNITY HAVE 5005 03:23:01,327 --> 03:23:03,196 REACTED TO THE GOALS OF THIS 5006 03:23:03,196 --> 03:23:04,730 WHITE HOUSE WOMEN'S HEALTH 5007 03:23:04,730 --> 03:23:06,032 RESEARCH INITIATIVE AS YOU'VE 5008 03:23:06,032 --> 03:23:08,901 BEEN TRAVELING THE COUNTRY AND 5009 03:23:08,901 --> 03:23:10,570 SPEAKING TO DIFFERENT GROUPS? 5010 03:23:10,570 --> 03:23:11,971 >> WELL, IT'S HARD TO CAPTURE 5011 03:23:11,971 --> 03:23:14,373 THE RIGHT WORDS TO DESCRIBE THE 5012 03:23:14,373 --> 03:23:15,575 EXCITEMENT ABOUT THIS AND 5013 03:23:15,575 --> 03:23:16,542 ENTHUSIASM FOR THIS. 5014 03:23:16,542 --> 03:23:18,511 BUT I WILL SAY A COUPLE THINGS, 5015 03:23:18,511 --> 03:23:20,146 IN ANSWER TO YOUR QUESTION. 5016 03:23:20,146 --> 03:23:22,048 ONE IS THAT THE GENDER POLICY 5017 03:23:22,048 --> 03:23:24,550 COUNCIL HAS BEEN IN EXISTENCE 5018 03:23:24,550 --> 03:23:25,852 SINCE MARCH OF 2021, AND THEY 5019 03:23:25,852 --> 03:23:27,587 HAVE DONE A VARIETY OF 5020 03:23:27,587 --> 03:23:29,021 INITIATIVES OVER THAT PERIOD OF 5021 03:23:29,021 --> 03:23:29,355 TIME. 5022 03:23:29,355 --> 03:23:31,190 THEY TOLD ME THAT THEY HAVE 5023 03:23:31,190 --> 03:23:33,526 NEVER SEEN ANYTHING QUITE LIKE 5024 03:23:33,526 --> 03:23:34,927 THIS. 5025 03:23:34,927 --> 03:23:38,097 THE OUTPOURING OF INTEREST, 5026 03:23:38,097 --> 03:23:39,832 SUPPORT, OPPORTUNITY, IS JUST 5027 03:23:39,832 --> 03:23:40,299 EXTRAORDINARY. 5028 03:23:40,299 --> 03:23:42,902 AND IN TALKING TO RESEARCHERS IN 5029 03:23:42,902 --> 03:23:44,136 PARTICULAR, AND EVEN TODAY WHEN 5030 03:23:44,136 --> 03:23:46,172 I HAD THE OPPORTUNITY TO TALK TO 5031 03:23:46,172 --> 03:23:49,141 MANY OF YOU, IT'S JUST REALLY 5032 03:23:49,141 --> 03:23:50,443 WONDERFULLY EXCITING FOR ME 5033 03:23:50,443 --> 03:23:52,111 PERSONALLY TO HEAR YOUR 5034 03:23:52,111 --> 03:23:53,312 EXCITEMENT ABOUT THIS, TO HEAR 5035 03:23:53,312 --> 03:23:55,815 THAT THINGS ARE GOING TO SHIFT 5036 03:23:55,815 --> 03:23:57,483 AND CHANGE, AND WE ARE REALLY 5037 03:23:57,483 --> 03:23:59,018 WORKING AS HARD AS WE CAN TO 5038 03:23:59,018 --> 03:24:02,088 SHOW THIS IS GOING TO CHANGE. 5039 03:24:02,088 --> 03:24:07,326 THAT WE'RE LOOKING FOR 5040 03:24:07,326 --> 03:24:08,761 SHORT-TERM MARKERS BUT IT TAKES 5041 03:24:08,761 --> 03:24:10,396 A LONG TIME, BUT IT CAN'T TAKE 5042 03:24:10,396 --> 03:24:12,398 AS LONG AS IT HAS IN THE PAST. 5043 03:24:12,398 --> 03:24:14,901 IT HAS TO MOVE FORWARD AS A MUCH 5044 03:24:14,901 --> 03:24:16,535 MORE RAPID PACE. 5045 03:24:16,535 --> 03:24:18,938 SO, WE WANT YOU TO JOIN WITH US 5046 03:24:18,938 --> 03:24:21,240 IN THAT EFFORT. 5047 03:24:21,240 --> 03:24:23,075 SO RESEARCHERS IN MY EXPERIENCE, 5048 03:24:23,075 --> 03:24:31,617 SIMPLY SAID, ARE OVER THE MOON. 5049 03:24:31,617 --> 03:24:32,618 >> YOU MENTIONED COMMON DATA 5050 03:24:32,618 --> 03:24:33,052 ELEMENTS, CAROLYN. 5051 03:24:33,052 --> 03:24:36,122 I WONDER IF YOU MIGHT SHARE YOUR 5052 03:24:36,122 --> 03:24:37,390 PERSPECTIVE ON POTENTIAL IMPACT 5053 03:24:37,390 --> 03:24:39,625 OF DEVELOPING NEW COMMON DATA 5054 03:24:39,625 --> 03:24:40,927 ELEMENTS THAT ARE SPECIFICALLY 5055 03:24:40,927 --> 03:24:43,229 DESIGNED WITH WOMEN IN MIND, THE 5056 03:24:43,229 --> 03:24:44,664 TOPIC CAME UP EARLIER, DR. 5057 03:24:44,664 --> 03:24:45,631 ANDERSON ASKED A QUESTION ABOUT 5058 03:24:45,631 --> 03:24:45,932 IT. 5059 03:24:45,932 --> 03:24:49,468 OF COURSE YOU HEARD FROM DR. 5060 03:24:49,468 --> 03:24:50,336 BERTAGNOLLI HOW IMPORTANT DATA 5061 03:24:50,336 --> 03:24:52,505 ELEMENTS CAN BE AS WE MOVE 5062 03:24:52,505 --> 03:24:54,307 FORWARD TO BE ABLE TO CONNECT 5063 03:24:54,307 --> 03:24:56,342 THOSE DOTS AND CREATE THAT 5064 03:24:56,342 --> 03:24:58,444 FEDERATED DATA SYSTEM THAT SHE 5065 03:24:58,444 --> 03:24:58,878 REFERENCED. 5066 03:24:58,878 --> 03:25:03,916 WHAT ARE YOUR THOUGHTS ON THE 5067 03:25:03,916 --> 03:25:06,118 POTENTIAL IMPACT OF SUCH? 5068 03:25:06,118 --> 03:25:07,954 >> THEY COULD HAVE A HUGE IMPACT 5069 03:25:07,954 --> 03:25:09,822 ON RESEARCH BECAUSE IF THEY ARE 5070 03:25:09,822 --> 03:25:12,692 DONE WELL, THEY PROVIDE THE 5071 03:25:12,692 --> 03:25:15,094 OPPORTUNITY TO CHARACTERIZE 5072 03:25:15,094 --> 03:25:15,728 VARIOUS STUDIES, VARIOUS 5073 03:25:15,728 --> 03:25:18,698 PARTICIPANTS, OTHER WAYS IN 5074 03:25:18,698 --> 03:25:21,367 WHICH WE WOULD UNDERSTAND ACROSS 5075 03:25:21,367 --> 03:25:23,169 THE FEDERAL GOVERNMENT WHO IS 5076 03:25:23,169 --> 03:25:24,837 FUNDING RESEARCH ON WHAT ASPECTS 5077 03:25:24,837 --> 03:25:26,806 OF WOMEN'S HEALTH. 5078 03:25:26,806 --> 03:25:28,741 AND THIS WOULD PROVIDE FOR 5079 03:25:28,741 --> 03:25:30,643 FURTHER EXAMINATION OF DATA, IT 5080 03:25:30,643 --> 03:25:31,944 COULD PROVIDE FOR META-ANALYSES 5081 03:25:31,944 --> 03:25:32,278 OF DATA. 5082 03:25:32,278 --> 03:25:34,213 I THINK IT WOULD OPEN UP A WHOLE 5083 03:25:34,213 --> 03:25:38,150 NEW AREA IN WHICH WE COULD LOOK 5084 03:25:38,150 --> 03:25:38,918 AT WELL-DONE RESEARCH BUT LOOK 5085 03:25:38,918 --> 03:25:41,887 AT IT IN A WIDER SCOPE. 5086 03:25:41,887 --> 03:25:44,290 SO I THINK IT'S REALLY A VERY 5087 03:25:44,290 --> 03:25:47,026 VALUABLE THING TO DO. 5088 03:25:47,026 --> 03:25:49,528 >> THE ANALYTIC APPROACHES AND 5089 03:25:49,528 --> 03:25:51,397 POSSIBILITIES DO SEEM REALLY 5090 03:25:51,397 --> 03:25:53,733 RICH AND ALMOST INFINITE IF WE 5091 03:25:53,733 --> 03:25:55,901 COULD ACTUALLY BE ABLE TO PUT 5092 03:25:55,901 --> 03:25:57,670 ALL OF THAT DATA TO WORK. 5093 03:25:57,670 --> 03:25:57,970 >> RIGHT. 5094 03:25:57,970 --> 03:26:00,373 >> SO I'M EXCITED ABOUT THAT AS 5095 03:26:00,373 --> 03:26:00,806 WELL. 5096 03:26:00,806 --> 03:26:03,109 ONE QUESTION THAT LOTS OF FOLKS 5097 03:26:03,109 --> 03:26:05,378 HAVE BEEN ASKING ME SO I'M GOING 5098 03:26:05,378 --> 03:26:10,316 TO ASK YOU, WHAT ARE THE NEXT 5099 03:26:10,316 --> 03:26:11,550 STEPS? 5100 03:26:11,550 --> 03:26:13,953 YOU OUTLINED THIS TASK FROM THE 5101 03:26:13,953 --> 03:26:15,154 PRESIDENTIAL MEMO TO AGENCY 5102 03:26:15,154 --> 03:26:16,689 COMMITMENT TO EXECUTIVE ORDER 5103 03:26:16,689 --> 03:26:21,827 AND NOW TO ACTIONS THAT WE'VE 5104 03:26:21,827 --> 03:26:22,828 TALKED ABOUT TAKING, DELINEATING 5105 03:26:22,828 --> 03:26:25,798 SEVERAL NIH ACTIONS, WHAT'S 5106 03:26:25,798 --> 03:26:26,332 NEXT? 5107 03:26:26,332 --> 03:26:27,233 >> A COUPLE THINGS REALLY 5108 03:26:27,233 --> 03:26:29,735 IMPORTANT IS FIRST WE HAVE TO 5109 03:26:29,735 --> 03:26:32,371 REALLY ENSURE THAT THE EXECUTIVE 5110 03:26:32,371 --> 03:26:35,775 ORDER, THE E.O. IS IMPLEMENTED. 5111 03:26:35,775 --> 03:26:38,177 I'VE SHOWN BROAD CATEGORIES BUT 5112 03:26:38,177 --> 03:26:39,278 THE SPECIFICITY UNDER EACH 5113 03:26:39,278 --> 03:26:40,479 CATEGORY IS GREAT. 5114 03:26:40,479 --> 03:26:43,115 AND IT RELATES BACK TO EACH 5115 03:26:43,115 --> 03:26:43,716 AGENCY. 5116 03:26:43,716 --> 03:26:45,317 SO, WE'RE GOING TO BE CONVENING 5117 03:26:45,317 --> 03:26:46,952 A WORKING GROUP THAT'S 5118 03:26:46,952 --> 03:26:50,589 CO-CHAIRED BY DR. JANINE CLAYTON 5119 03:26:50,589 --> 03:26:53,726 AND MYSELF, TO ENSURE THAT 5120 03:26:53,726 --> 03:26:56,262 THERE'S INTERAGENCY ALIGNMENT 5121 03:26:56,262 --> 03:26:57,329 ACROSS THESE INITIATIVES BECAUSE 5122 03:26:57,329 --> 03:26:58,764 WE DON'T WANT EVERYBODY DOING IT 5123 03:26:58,764 --> 03:27:01,100 DIFFERENTLY SO CAN YOU NOT LOOK 5124 03:27:01,100 --> 03:27:02,535 ACROSS ALL THESE AREAS, THESE 5125 03:27:02,535 --> 03:27:04,070 IMPORTANT AREAS. 5126 03:27:04,070 --> 03:27:05,604 PEOPLE HAVE MENTIONED OUTSIDE 5127 03:27:05,604 --> 03:27:08,007 THE NIH, CDC IS DOING IMPORTANT 5128 03:27:08,007 --> 03:27:09,341 WORK, SAMHSA IS DOING IMPORTANT 5129 03:27:09,341 --> 03:27:12,611 WORK, ALL OF THESE AGENCIES NOW 5130 03:27:12,611 --> 03:27:14,480 COULD WORK TOGETHER IN A MORE 5131 03:27:14,480 --> 03:27:15,448 UNIFORM WAY. 5132 03:27:15,448 --> 03:27:17,316 THAT'S ONE THING THAT WE'RE 5133 03:27:17,316 --> 03:27:23,022 DOING IN TERMS OF IMPLEMENTING 5134 03:27:23,022 --> 03:27:25,624 FURTHER WHAT'S GOING ON WITH THE 5135 03:27:25,624 --> 03:27:26,659 INITIATIVE ITSELF. 5136 03:27:26,659 --> 03:27:27,760 THE OTHER THING THAT'S REALLY 5137 03:27:27,760 --> 03:27:29,895 IMPORTANT IS WE'RE GOING TO 5138 03:27:29,895 --> 03:27:31,430 START WORKING DIRECTLY WITH 5139 03:27:31,430 --> 03:27:31,764 CONGRESS. 5140 03:27:31,764 --> 03:27:34,166 SO THAT WOULD MEAN BRIEFINGS TO 5141 03:27:34,166 --> 03:27:36,135 VARIOUS PEOPLE WHO HAVE NOW 5142 03:27:36,135 --> 03:27:37,236 ALREADY APPROACHED US, AND SAID 5143 03:27:37,236 --> 03:27:40,172 THIS IS SOMETHING OF INTEREST TO 5144 03:27:40,172 --> 03:27:40,639 US. 5145 03:27:40,639 --> 03:27:44,143 SO WE'VE BEEN TALKING TO PEOPLE, 5146 03:27:44,143 --> 03:27:47,079 ADVOCACY GROUPS WITHIN OUR HOME 5147 03:27:47,079 --> 03:27:48,747 DISTRICTS, CONCERNED ABOUT 5148 03:27:48,747 --> 03:27:50,249 ENDOMETRIOSIS OR CONCERNED ABOUT 5149 03:27:50,249 --> 03:27:52,418 OTHER DISEASES OR CONDITIONS 5150 03:27:52,418 --> 03:27:53,452 THAT WOMEN SUFFER 5151 03:27:53,452 --> 03:27:54,086 DISPROPORTIONATELY. 5152 03:27:54,086 --> 03:27:56,322 IT'S ALL SORTS OF THINGS THAT 5153 03:27:56,322 --> 03:27:58,591 ARE COMING IN TO US OF 5154 03:27:58,591 --> 03:28:00,326 EXPRESSIONS OF INTEREST ABOUT 5155 03:28:00,326 --> 03:28:00,726 PARTICULAR AREAS. 5156 03:28:00,726 --> 03:28:02,094 AND SO WE WANT TO GO TO CONGRESS 5157 03:28:02,094 --> 03:28:04,296 AND TALK WITH THEM ABOUT THAT SO 5158 03:28:04,296 --> 03:28:07,433 THEY KNOW THAT THEY ARE OUT OF 5159 03:28:07,433 --> 03:28:08,234 THEIR HOME DISTRICTS, PEOPLE 5160 03:28:08,234 --> 03:28:10,402 WANT TO SEE THIS MOVE FORWARD 5161 03:28:10,402 --> 03:28:11,837 AND HELP US THINK ABOUT 5162 03:28:11,837 --> 03:28:13,205 CHAMPIONS FROM BOTH SIDES OF THE 5163 03:28:13,205 --> 03:28:16,542 AISLE WHO THINK THIS IS 5164 03:28:16,542 --> 03:28:21,113 IMPORTANT. 5165 03:28:21,113 --> 03:28:21,714 HISTORICALLY IN THE CONGRESS, 5166 03:28:21,714 --> 03:28:26,719 THERE HAS BEEN THE CAPACITY TO 5167 03:28:26,719 --> 03:28:28,154 MAKE COMMONLY ADVANTAGEOUS 5168 03:28:28,154 --> 03:28:30,556 DECISIONS ON EDUCATION AND 5169 03:28:30,556 --> 03:28:30,823 HEALTH. 5170 03:28:30,823 --> 03:28:32,758 AND WE'RE HOPING THAT THAT STILL 5171 03:28:32,758 --> 03:28:35,294 EXISTS TODAY TO SOME DEGREE, 5172 03:28:35,294 --> 03:28:36,162 PEOPLE CAN GET TOGETHER ON THE 5173 03:28:36,162 --> 03:28:37,963 HEALTH OF THE NATION BECAUSE WE 5174 03:28:37,963 --> 03:28:40,866 DO KNOW AND THERE ARE DATA TO 5175 03:28:40,866 --> 03:28:43,802 INDICATE AS WOMEN'S HEALTH 5176 03:28:43,802 --> 03:28:45,037 IMPROVES, FAMILIES IMPROVE, AND 5177 03:28:45,037 --> 03:28:46,772 THE SOCIETY IMPROVES, AND 5178 03:28:46,772 --> 03:28:47,706 ECONOMICALLY THERE'S 5179 03:28:47,706 --> 03:28:48,007 IMPROVEMENT. 5180 03:28:48,007 --> 03:28:49,608 SO, ALL OF THIS IS VERY TIED 5181 03:28:49,608 --> 03:28:52,244 TOGETHER FOR US AND FOR THE 5182 03:28:52,244 --> 03:28:54,246 PRESIDENT AND FIRST LADY, AND 5183 03:28:54,246 --> 03:28:55,881 CONSIDER THIS A HOLISTIC PICTURE 5184 03:28:55,881 --> 03:29:02,321 WHICH IS PART OF WHY IN ADDITION 5185 03:29:02,321 --> 03:29:04,056 TO THE MONIES THAT WE'RE TALKING 5186 03:29:04,056 --> 03:29:07,359 ABOUT HERE THERE'S A REAL 5187 03:29:07,359 --> 03:29:08,594 EQUIPMENT I THINK TO IMPROVING 5188 03:29:08,594 --> 03:29:10,296 THE HEALTH OF THE NATION IN A 5189 03:29:10,296 --> 03:29:17,536 WAY THAT REALLY DESERVES OUR 5190 03:29:17,536 --> 03:29:18,003 ATTENTION. 5191 03:29:18,003 --> 03:29:21,140 >> WE APPRECIATE YOU BEING HERE 5192 03:29:21,140 --> 03:29:22,908 AND SHARING THIS UNIQUE 5193 03:29:22,908 --> 03:29:23,642 PERSPECTIVE, LOOKING FORWARD TO 5194 03:29:23,642 --> 03:29:25,477 CONTINUING TO WORKING WITH YOU 5195 03:29:25,477 --> 03:29:26,845 ACROSS THE AGENCIES ON THESE 5196 03:29:26,845 --> 03:29:27,446 IMPORTANT ENDEAVORS. 5197 03:29:27,446 --> 03:29:30,883 I LIKE WHAT YOU SAID ABOUT 5198 03:29:30,883 --> 03:29:32,084 ENHANCING COORDINATION AND 5199 03:29:32,084 --> 03:29:34,520 ENSURING THAT'S IN HARMONY SO WE 5200 03:29:34,520 --> 03:29:36,655 CAN ACTUALLY ACCELERATE 5201 03:29:36,655 --> 03:29:38,424 PROGRESS. 5202 03:29:38,424 --> 03:29:39,825 YOU USE THAT WORD, ACCELERATE, 5203 03:29:39,825 --> 03:29:42,061 IN ONE OF YOUR SLIDES. 5204 03:29:42,061 --> 03:29:43,162 WE'VE MADE SUBSTANTIAL 5205 03:29:43,162 --> 03:29:43,796 INVESTMENTS, WE'VE LEARNED SO 5206 03:29:43,796 --> 03:29:45,764 MUCH BUT THERE ARE GAPS IN OUR 5207 03:29:45,764 --> 03:29:47,099 KNOWLEDGE THAT AFFECT OUR 5208 03:29:47,099 --> 03:29:51,604 ABILITY TO DELIVER 5209 03:29:51,604 --> 03:29:52,605 EVIDENCE-BASED CARE TO WOMEN. 5210 03:29:52,605 --> 03:29:53,906 I APPRECIATE THE FOCUS ON 5211 03:29:53,906 --> 03:29:54,773 MID-LIFE HEALTH AS WELL. 5212 03:29:54,773 --> 03:29:56,609 THANK YOU AGAIN. 5213 03:29:56,609 --> 03:29:57,276 YOU MENTIONED, CAROLYN, THAT 5214 03:29:57,276 --> 03:30:00,145 THERE WOULD BE A PLACE WHERE 5215 03:30:00,145 --> 03:30:02,748 SOMEBODY COULD GET INFORMATION. 5216 03:30:02,748 --> 03:30:03,983 YOU MENTIONED FACTSHEETS. 5217 03:30:03,983 --> 03:30:07,019 WHITE HOUSE FACTSHEETS. 5218 03:30:07,019 --> 03:30:07,886 >> YES, THE FACTSHEETS, SO FIRST 5219 03:30:07,886 --> 03:30:12,157 OF ALL IF YOU GO TO THE 5220 03:30:12,157 --> 03:30:13,125 WHITEHOUSE.GOV WEBSITE YOU CAN 5221 03:30:13,125 --> 03:30:17,196 GO IN THERE AND YOU CAN PULL OUT 5222 03:30:17,196 --> 03:30:17,730 THIS INFORMATION. 5223 03:30:17,730 --> 03:30:21,233 THERE'S ALSO ON THE LAST SLIDE I 5224 03:30:21,233 --> 03:30:22,401 GAVE A PARTICULAR E-MAIL 5225 03:30:22,401 --> 03:30:24,069 ADDRESS, AND IF YOU HAVE 5226 03:30:24,069 --> 03:30:25,070 QUESTIONS YOU CAN WRITE TO THAT 5227 03:30:25,070 --> 03:30:28,007 OR IF YOU WANT TO BE ON OUR 5228 03:30:28,007 --> 03:30:29,308 MAILING LIST BECAUSE WHEN THING 5229 03:30:29,308 --> 03:30:31,076 COME OUT WE THINK ARE WORTHY OF 5230 03:30:31,076 --> 03:30:32,478 YOUR ATTENTION IN YOUR BUSY DAY, 5231 03:30:32,478 --> 03:30:37,650 SO YOU'RE NOT GOING TO GET ONE 5232 03:30:37,650 --> 03:30:38,517 EVERY WEEK, YOU'LL GET SOMETHING 5233 03:30:38,517 --> 03:30:42,121 FROM US ABOUT WHAT THE LATEST 5234 03:30:42,121 --> 03:30:42,488 INFORMATION IS. 5235 03:30:42,488 --> 03:30:46,725 AND SO WE'RE VERY -- I THINK 5236 03:30:46,725 --> 03:30:47,493 THIS ADMINISTRATION, THIS 5237 03:30:47,493 --> 03:30:50,329 EFFORT, IS VERY ENGAGED WITH THE 5238 03:30:50,329 --> 03:30:50,562 PUBLIC. 5239 03:30:50,562 --> 03:30:52,631 AND WANTS TO HEAR FROM PEOPLE 5240 03:30:52,631 --> 03:30:54,266 AND WANTS US TO ALL WORK 5241 03:30:54,266 --> 03:30:58,637 TOGETHER TO GET THIS DONE. 5242 03:30:58,637 --> 03:30:59,538 >> THANK YOU. 5243 03:30:59,538 --> 03:31:05,044 PLEASE JOIN ME IN THANKING DR. 5244 03:31:05,044 --> 03:31:05,978 CAROLYN MAZURE. 5245 03:31:05,978 --> 03:31:06,412 >> THANK YOU. 5246 03:31:06,412 --> 03:31:09,148 WE'RE A FEW MINUTES EARLY. 5247 03:31:09,148 --> 03:31:12,017 I WOULD FIRST OF ALL LIKE TO 5248 03:31:12,017 --> 03:31:13,652 INVITE OUR NEXT PANELISTS. 5249 03:31:13,652 --> 03:31:16,522 WE'RE DOING A TRANSITION. 5250 03:31:16,522 --> 03:31:20,092 I WOULD LIKE DR. BRINTON, DR. 5251 03:31:20,092 --> 03:31:21,460 BURNETT-BOWIE AND DR. HODIS TO 5252 03:31:21,460 --> 03:31:32,004 GO TO THE FRONT AS WELL AS ALSO 5253 03:31:34,540 --> 03:31:36,008 DR. CHHANDA DUTTA. 5254 03:31:36,008 --> 03:31:36,975 DON'T WALK AWAY BECAUSE WE'RE 5255 03:31:36,975 --> 03:31:43,415 GOING TO START ON TIME. 5256 03:31:43,415 --> 03:31:48,020 LET ME TALK ABOUT DR. DUTTA 5257 03:31:48,020 --> 03:31:49,755 MODERATING THE NEXT PANEL, 5258 03:31:49,755 --> 03:31:52,224 FOCUSING ON MIDDLE LIFE HEALTH 5259 03:31:52,224 --> 03:31:54,226 OF WOMEN AND MENOPAUSE. 5260 03:31:54,226 --> 03:31:57,162 CURRENTLY THE CHIEF OF THE 5261 03:31:57,162 --> 03:31:58,864 CLINICAL GERONTOLOGY BRANCH, 5262 03:31:58,864 --> 03:32:00,733 DIVISION OF GERIATRICS AND 5263 03:32:00,733 --> 03:32:02,134 CLINICAL GERONTOLOGY OF THE 5264 03:32:02,134 --> 03:32:03,469 NATIONAL INSTITUTES OF AGING. 5265 03:32:03,469 --> 03:32:06,305 DURING HER TENURE AT NIH, SHE 5266 03:32:06,305 --> 03:32:12,444 HAS OVERSEEN RESEARCH ON AGING 5267 03:32:12,444 --> 03:32:19,551 OF THE MUSCULOSKELETAL SYSTEM, 5268 03:32:19,551 --> 03:32:20,352 SARCOPENIA, INCONTINENCE, 5269 03:32:20,352 --> 03:32:21,387 NUTRITION AND METABOLISM TO NAME 5270 03:32:21,387 --> 03:32:23,389 A FEW, SUPPORTING RESEARCH ON 5271 03:32:23,389 --> 03:32:25,557 AGING ACROSS THE LIFESPAN. 5272 03:32:25,557 --> 03:32:26,992 FOR EXAMPLE, AREAS SUCH AS 5273 03:32:26,992 --> 03:32:29,628 INFLUENCE OF EARLY AND MID-LIFE 5274 03:32:29,628 --> 03:32:32,564 CHANGES ON HEALTH ON LATER LIFE 5275 03:32:32,564 --> 03:32:34,900 HEALTH, IMPACT OF THE MENOPAUSAL 5276 03:32:34,900 --> 03:32:37,636 TRANSITION ON LATER LIFE HEALTH, 5277 03:32:37,636 --> 03:32:39,371 STUDIES IN HUMAN LONGEVITY AND 5278 03:32:39,371 --> 03:32:43,075 HEALTHY AGING, NOT ONLY FROM THE 5279 03:32:43,075 --> 03:32:44,710 GENOMIC AND OTHER FACTORS BUT 5280 03:32:44,710 --> 03:32:48,013 ALSO REALLY PUTTING IT INTO THE 5281 03:32:48,013 --> 03:32:49,982 TRANSLATIONAL FOCUS OF CLINICAL 5282 03:32:49,982 --> 03:32:51,517 ISSUES AROUND AGING RESEARCH. 5283 03:32:51,517 --> 03:32:54,453 SO I'M GOING TO TURN IT OVER TO 5284 03:32:54,453 --> 03:32:58,624 YOU, DR. DUTTA, AND THE PANEL. 5285 03:32:58,624 --> 03:33:00,926 >> THANK YOU, DR. CLAYTON AND 5286 03:33:00,926 --> 03:33:03,128 DR. OTA WANG FOR THIS INVITATION 5287 03:33:03,128 --> 03:33:05,764 TO MODERATE THIS NEXT PANEL. 5288 03:33:05,764 --> 03:33:09,134 IT'S MY GREAT PLEASURE TO 5289 03:33:09,134 --> 03:33:11,336 INTRODUCE OUR STELLAR PANEL OF 5290 03:33:11,336 --> 03:33:12,137 SPEAKERS. 5291 03:33:12,137 --> 03:33:14,506 THEY INCLUDE DR. ROBERTA DIAZ 5292 03:33:14,506 --> 03:33:18,377 BRINTON, DR. SHERRI ANN 5293 03:33:18,377 --> 03:33:23,715 BURNETT-BOWIE, DR. HOWARD HODIS. 5294 03:33:23,715 --> 03:33:28,854 DR. BRINTON IS AT UNIVERSITY OF 5295 03:33:28,854 --> 03:33:32,157 ARIZONA, DEVOTED TO DEVELOPING 5296 03:33:32,157 --> 03:33:34,126 THERAPEUTICS FOR AGE-ASSOCIATED 5297 03:33:34,126 --> 03:33:35,527 NEURODEGENERATIVE DISEASES 5298 03:33:35,527 --> 03:33:38,797 INCLUDING ALZHEIMER'S, 5299 03:33:38,797 --> 03:33:39,898 PARKINSON'S, MULTIPLE SCLEROSIS 5300 03:33:39,898 --> 03:33:41,533 AND ALS. 5301 03:33:41,533 --> 03:33:44,937 SHE HAS AUTHORED MORE THAN 250 5302 03:33:44,937 --> 03:33:47,339 SCIENTIFIC PUBLICATIONS, HOLDS 5303 03:33:47,339 --> 03:33:50,642 MULTIPLE PATENTS, FOUNDED TWO 5304 03:33:50,642 --> 03:33:52,711 BIOTECH STARTUPS, MOST RECENTLY 5305 03:33:52,711 --> 03:33:54,680 NEW THERAPEUTICS. 5306 03:33:54,680 --> 03:33:56,482 SHE'S AN INTERNATIONALLY 5307 03:33:56,482 --> 03:33:57,749 RECOGNIZED EXPERT ON A.D., 5308 03:33:57,749 --> 03:34:01,019 DISCOVERIES HAVE LED TO 5309 03:34:01,019 --> 03:34:02,488 INNOVATIVE THERAPEUTICS TO 5310 03:34:02,488 --> 03:34:09,795 PREVENT, DELAY, TREAT A.D., 5311 03:34:09,795 --> 03:34:11,630 CONDUCTED TWO PHASE IIA CLINICAL 5312 03:34:11,630 --> 03:34:18,871 TRIALS, AND IS CURRENTLY 5313 03:34:18,871 --> 03:34:24,643 CONDUCTING THREE PHASE 2B 5314 03:34:24,643 --> 03:34:25,244 INCLUDING ALLOPREGNANOLONE TO 5315 03:34:25,244 --> 03:34:26,078 REGENERATE THE BRAIN AND 5316 03:34:26,078 --> 03:34:28,714 CLINICAL TRIALS TO DETERMINE 5317 03:34:28,714 --> 03:34:33,752 SAFETY AND EFFICACY TO PROMOTE 5318 03:34:33,752 --> 03:34:34,419 BRAIN GLUCOSE METABOLISM, 5319 03:34:34,419 --> 03:34:37,689 COGNITION, ALLEVIATE MENOPAUSAL 5320 03:34:37,689 --> 03:34:37,956 SYMPTOMS. 5321 03:34:37,956 --> 03:34:39,691 DR. BRINTON'S SERVICE INCLUDE 5322 03:34:39,691 --> 03:34:42,528 SERVING ON NIH DIRECTOR'S 5323 03:34:42,528 --> 03:34:43,929 ADVISORY COMMITTEE, NIA 5324 03:34:43,929 --> 03:34:46,899 SCIENTIFIC ADVISORY BOARD, AND 5325 03:34:46,899 --> 03:34:48,433 ALZHEIMER'S DISEASE DRUG 5326 03:34:48,433 --> 03:34:52,371 DISCOVERY FOUNDATION BOARD OF 5327 03:34:52,371 --> 03:34:52,704 GOVERNORS. 5328 03:34:52,704 --> 03:34:54,439 SIGN 5329 03:34:54,439 --> 03:34:57,543 SIGN 5330 03:34:57,543 --> 03:35:02,147 SCIENTIST OF THE YEAR FROM 5331 03:35:02,147 --> 03:35:02,915 ALZHEIMER'S FOUNDATION, ARIZONA 5332 03:35:02,915 --> 03:35:05,183 BIOSCIENCE RESEARCHER OF THE 5333 03:35:05,183 --> 03:35:08,287 YEAR, U.S. PRECEDENTIAL CITIZENS 5334 03:35:08,287 --> 03:35:10,355 MEDAL, HIGHEST CIVILIAN HONOR 5335 03:35:10,355 --> 03:35:15,727 FOR STEM EDUCATION TO ADVANCE 5336 03:35:15,727 --> 03:35:19,464 UNDERREPRESENTED DISCOVERIES. 5337 03:35:19,464 --> 03:35:21,867 SECOND SPEAKER DR. 5338 03:35:21,867 --> 03:35:26,605 BURNETT-BOWIE, ADULT 5339 03:35:26,605 --> 03:35:27,706 ENDOCRINOLOGIST, SPECIALIZING IN 5340 03:35:27,706 --> 03:35:28,774 OSTEOPOROSIS AT MASS GENERAL, 5341 03:35:28,774 --> 03:35:32,010 ASSOCIATE PROFESSOR OF MEDICINE 5342 03:35:32,010 --> 03:35:33,812 AT HARVARD MEDICAL SCHOOL, 5343 03:35:33,812 --> 03:35:35,714 INVESTIGATION FOCUSES ON 5344 03:35:35,714 --> 03:35:38,517 MENOPAUSE AND AGING, 5345 03:35:38,517 --> 03:35:40,786 EPIDEMIOLOGY, TREATMENTS FOR 5346 03:35:40,786 --> 03:35:43,288 OSTEOPOROSIS, PHOSPHATE AND 5347 03:35:43,288 --> 03:35:44,556 VITAMIN D PHYSIOLOGY, PRINCIPAL 5348 03:35:44,556 --> 03:35:46,725 INVESTIGATOR FOR THE STUDY OF 5349 03:35:46,725 --> 03:35:56,401 WOMEN'S HEALTH ACROSS THE 5350 03:35:56,401 --> 03:35:59,504 NATION, 25-YEAR STUDY WHICH HAS 5351 03:35:59,504 --> 03:36:00,606 TRANSFORMED OUR UNDERSTANDING OF 5352 03:36:00,606 --> 03:36:04,009 THE TRANSITION ON A VARIETY OF 5353 03:36:04,009 --> 03:36:04,710 HEALTH OUTCOMES. 5354 03:36:04,710 --> 03:36:07,212 I SHOULD ADD AS THE PROGRAM 5355 03:36:07,212 --> 03:36:09,381 OFFICER FOR THE SWAN STUDY, IT'S 5356 03:36:09,381 --> 03:36:13,785 MY PLEASURE TO HAVE WORKED WITH 5357 03:36:13,785 --> 03:36:16,121 DR. BURNETT-BOWIE. 5358 03:36:16,121 --> 03:36:16,755 IN ADDITION CO-CHAIRED AMERICAN 5359 03:36:16,755 --> 03:36:19,057 SOCIETY FOR BONE AND MINERAL 5360 03:36:19,057 --> 03:36:21,994 RESEARCH TASK FORCE ON CLINICAL 5361 03:36:21,994 --> 03:36:23,428 ALGORITHMS FOR FRACTURE RISK, 5362 03:36:23,428 --> 03:36:25,931 WHICH INVESTIGATED USE OF RACE 5363 03:36:25,931 --> 03:36:28,467 AND ETHNICITY IN THE WIDELY USE 5364 03:36:28,467 --> 03:36:30,769 FRACTURE RISK ASSESSMENT TOOL 5365 03:36:30,769 --> 03:36:32,771 OTHERWISE KNOWN AS FRAX. 5366 03:36:32,771 --> 03:36:34,740 SHE'S NATIONALLY RECOGNIZED FOR 5367 03:36:34,740 --> 03:36:38,677 INNOVATIONS AND CARING FOR 5368 03:36:38,677 --> 03:36:40,646 PATIENTS WITH MINERAL DISORDERS 5369 03:36:40,646 --> 03:36:42,948 DEFINING BIAS IN PATIENT CARE 5370 03:36:42,948 --> 03:36:45,183 AND EDUCATION AND HER TEACHING 5371 03:36:45,183 --> 03:36:48,086 AND MENTORSHIP. 5372 03:36:48,086 --> 03:36:49,755 DR. BURNETT-BOWIE ONGOING GOALS 5373 03:36:49,755 --> 03:36:52,924 INCLUDE CONTINUED DEVELOPMENT OF 5374 03:36:52,924 --> 03:36:55,193 INNOVATIVE APPROACHES FOR 5375 03:36:55,193 --> 03:36:56,728 ADDRESSING DISPARITIES IN 5376 03:36:56,728 --> 03:36:57,929 OSTEOPOROSIS CARE AND IMPROVING 5377 03:36:57,929 --> 03:37:01,667 HEALTH OF WOMEN AT MID-LIFE AND 5378 03:37:01,667 --> 03:37:03,301 OLDER ADULTHOOD. 5379 03:37:03,301 --> 03:37:06,471 OUR THIRD SPEAKER IS DR. HOWARD 5380 03:37:06,471 --> 03:37:07,172 HODIS, OVERARCHING RESEARCH 5381 03:37:07,172 --> 03:37:12,277 INTERESTS HAVE BEEN IN THE FIELD 5382 03:37:12,277 --> 03:37:13,812 OF VASCULAR DISEASE AND 5383 03:37:13,812 --> 03:37:16,314 ATHEROBIOLOGY WITH PURSUITS TO 5384 03:37:16,314 --> 03:37:19,518 UNDERSTAND GENETICS AND BIOLOGY 5385 03:37:19,518 --> 03:37:21,687 AND ETIOLOGY AND PROGRESSION 5386 03:37:21,687 --> 03:37:22,921 INCLUDING PREVENTION AND 5387 03:37:22,921 --> 03:37:23,555 INTERVENTION. 5388 03:37:23,555 --> 03:37:25,991 HIS RESEARCH INTERESTS ALSO 5389 03:37:25,991 --> 03:37:27,192 INCLUDE DEVELOPMENT AND 5390 03:37:27,192 --> 03:37:28,860 APPLICATION OF IMAGING AND 5391 03:37:28,860 --> 03:37:30,696 MEASUREMENT TOOLS FOR THE 5392 03:37:30,696 --> 03:37:34,733 ASSESSMENT, SCREENING, 5393 03:37:34,733 --> 03:37:39,237 PREVENTION AND TREATMENT OF 5394 03:37:39,237 --> 03:37:40,205 ATHEROSCLEROSIS AND 5395 03:37:40,205 --> 03:37:41,973 CARDIOVASCULAR DISEASE, SPANS 5396 03:37:41,973 --> 03:37:43,308 BASIC TO CLINICAL SCIENCE 5397 03:37:43,308 --> 03:37:45,577 INCLUDING LARGE POPULATION 5398 03:37:45,577 --> 03:37:47,345 STUDIES AND INTERVENTION TRIALS. 5399 03:37:47,345 --> 03:37:51,049 WITH 30 YEARS OF CONTINUOUS NIH 5400 03:37:51,049 --> 03:37:53,685 FUNDING, DR. HODIS AS EXTENSIVE 5401 03:37:53,685 --> 03:37:56,321 EXPERIENCE AS PRINCIPAL 5402 03:37:56,321 --> 03:37:58,990 INVESTIGATOR FROM 22 NIH 5403 03:37:58,990 --> 03:38:01,760 PROJECTS INCLUDING EIGHT LARGE 5404 03:38:01,760 --> 03:38:04,529 RANDOMIZED TRIALS INTEGRATING 5405 03:38:04,529 --> 03:38:06,031 TRANSLATIONAL RESEARCH, 5406 03:38:06,031 --> 03:38:07,432 BIOMEDICAL ENGINEERING, 5407 03:38:07,432 --> 03:38:09,501 INTEGRATIVE BIOLOGY, SPANS BASIC 5408 03:38:09,501 --> 03:38:10,302 CLINICAL AND GENETIC 5409 03:38:10,302 --> 03:38:10,836 INVESTIGATION. 5410 03:38:10,836 --> 03:38:14,306 IN ADDITION HE HAS AN EXTENSIVE 5411 03:38:14,306 --> 03:38:18,477 COLLABORATIVE RECORD AS CO-P.I. 5412 03:38:18,477 --> 03:38:22,948 ON OTHER 30 NIH FEDERALLY FUNDED 5413 03:38:22,948 --> 03:38:23,315 PROJECTS. 5414 03:38:23,315 --> 03:38:26,685 AS THE DIRECTOR OF THE UNIT CORE 5415 03:38:26,685 --> 03:38:29,087 IMAGING AND RESEARCH READING 5416 03:38:29,087 --> 03:38:31,056 CENTER, HAS 30 YEARS OF 5417 03:38:31,056 --> 03:38:32,924 EXPERIENCE IN LEADING A STABLE 5418 03:38:32,924 --> 03:38:35,727 TEAM OF HIGHLY TRAINED AND 5419 03:38:35,727 --> 03:38:37,295 EXPERIENCED IMAGING SPECIALISTS 5420 03:38:37,295 --> 03:38:41,566 IN THE COORDINATION AND CONDUCT 5421 03:38:41,566 --> 03:38:43,201 OF 25 HUMAN CLINICAL STUDIES 5422 03:38:43,201 --> 03:38:45,170 PREDOMINANTLY NIH FUNDED AND 5423 03:38:45,170 --> 03:38:49,674 HAVE INCLUDED LARGE NATIONAL 5424 03:38:49,674 --> 03:38:56,114 TRIALS IN EPIDEMIOLOGIC STUDIES, 5425 03:38:56,114 --> 03:38:57,649 PROVIDING ARTERIAL IMAGING 5426 03:38:57,649 --> 03:39:01,353 SERVICES ENCOMPASSING ANATOMICAL 5427 03:39:01,353 --> 03:39:04,322 AND PHYSIOLOGICAL MEASUREMENTS 5428 03:39:04,322 --> 03:39:06,258 OF ATHEROSCLEROSIS PROVIDING A 5429 03:39:06,258 --> 03:39:07,726 FULL ARRAY OF RESEARCH AND 5430 03:39:07,726 --> 03:39:09,027 EXPERIENCE CAPABILITIES. 5431 03:39:09,027 --> 03:39:11,663 DR. HODIS HAS RECEIVED A NUMBER 5432 03:39:11,663 --> 03:39:14,699 OF HONORS AND AWARDS INCLUDING 5433 03:39:14,699 --> 03:39:17,035 NORTH AMERICAN MENOPAUSE SOCIETY 5434 03:39:17,035 --> 03:39:18,436 THOMAS CLARKSON OUTSTANDING 5435 03:39:18,436 --> 03:39:22,374 CLINICAL AND BASIC SCIENCE 5436 03:39:22,374 --> 03:39:24,376 RESEARCH AWARD, PEER-NOMINATED 5437 03:39:24,376 --> 03:39:26,144 AWARD FOR TRANSLATIONAL 5438 03:39:26,144 --> 03:39:27,145 CONTRIBUTIONS. 5439 03:39:27,145 --> 03:39:29,447 ALSO RECEIVED NASA TECHNOLOGY 5440 03:39:29,447 --> 03:39:32,284 AWARD, AND OUTSTANDING TEACHING 5441 03:39:32,284 --> 03:39:32,818 AWARD FROM UNIVERSITY OF 5442 03:39:32,818 --> 03:39:34,019 SOUTHERN CALIFORNIA. 5443 03:39:34,019 --> 03:39:37,222 HE HAS BEEN INDUCTED INTO THE 5444 03:39:37,222 --> 03:39:38,657 PRESTIGIOUS ASSOCIATION OF 5445 03:39:38,657 --> 03:39:40,058 AMERICAN PHYSICIANS AND HOLDS 5446 03:39:40,058 --> 03:39:43,128 MEMBERSHIP IN A VARIETY OF 5447 03:39:43,128 --> 03:39:45,564 SCIENTIFIC ORGANIZATIONS, SUCH 5448 03:39:45,564 --> 03:39:47,098 AS FELLOW OF THE AMERICAN HEART 5449 03:39:47,098 --> 03:39:47,732 ASSOCIATION. 5450 03:39:47,732 --> 03:39:50,502 HE SERVES ON SPECIAL EMPHASIS 5451 03:39:50,502 --> 03:39:52,037 PANELS FOR NIH AND REVIEW 5452 03:39:52,037 --> 03:39:54,539 COMMITTEES AND AS WELL AS OTHER 5453 03:39:54,539 --> 03:39:56,608 FUNDING AGENCIES. 5454 03:39:56,608 --> 03:40:00,812 DR. HODIS HAS DELIVERED MORE 5455 03:40:00,812 --> 03:40:02,981 THAN 325 INVITED PRESENTATIONS 5456 03:40:02,981 --> 03:40:05,851 WORLDWIDE, AUTHORED OR 5457 03:40:05,851 --> 03:40:09,354 CO-AUTHORED MORE THAN 275 5458 03:40:09,354 --> 03:40:10,722 ORIGINAL SCIENTIFIC 5459 03:40:10,722 --> 03:40:11,590 PEER-REVIEWED PUBLICATIONS. 5460 03:40:11,590 --> 03:40:14,693 PLEASE JOIN ME IN WELCOMING 5461 03:40:14,693 --> 03:40:22,133 THESE EXCELLENT SPEAKERS. 5462 03:40:22,133 --> 03:40:24,769 5463 03:40:24,769 --> 03:40:26,671 >> PLEASE HOLD YOUR QUESTIONS 5464 03:40:26,671 --> 03:40:29,074 UNTIL THE MODERATED Q&A SESSION 5465 03:40:29,074 --> 03:40:30,242 FOLLOWING THE THREE 5466 03:40:30,242 --> 03:40:31,076 PRESENTATIONS. 5467 03:40:31,076 --> 03:40:40,018 AND WITH THAT, I WILL INTRODUCE 5468 03:40:40,018 --> 03:40:40,318 DR. BRINTON. 5469 03:40:40,318 --> 03:40:41,319 >> THANK YOU. 5470 03:40:41,319 --> 03:40:43,421 THANK YOU ESPECIALLY TO DR. 5471 03:40:43,421 --> 03:40:47,359 CLAYTON AND OTA WANG FOR THE 5472 03:40:47,359 --> 03:40:49,661 INVITATION TO SHARE OUR 5473 03:40:49,661 --> 03:40:51,529 SCIENTIFIC JOURNEY OVER MANY 5474 03:40:51,529 --> 03:40:54,566 YEARS FUNDED BY THE NIA AND 5475 03:40:54,566 --> 03:40:57,535 WOMEN'S HEALTH, FROM MECHANISTIC 5476 03:40:57,535 --> 03:41:00,038 DISCOVERY TO DETERMINING WHETHER 5477 03:41:00,038 --> 03:41:01,473 OUR BASIC SCIENCE DISCOVERIES 5478 03:41:01,473 --> 03:41:03,208 TRANSLATE TO HUMAN BRAIN THROUGH 5479 03:41:03,208 --> 03:41:04,843 HUMAN BRAIN IMAGING TO 5480 03:41:04,843 --> 03:41:07,312 POPULATION DATA SCIENCE, AND 5481 03:41:07,312 --> 03:41:08,780 ULTIMATELY NOW THE CLINICAL 5482 03:41:08,780 --> 03:41:09,147 TRIALS. 5483 03:41:09,147 --> 03:41:10,782 SO, JUST A QUICK QUESTION. 5484 03:41:10,782 --> 03:41:13,585 IS THERE A POINTER? 5485 03:41:13,585 --> 03:41:19,324 5486 03:41:19,324 --> 03:41:20,659 THE TOP BUTTON? 5487 03:41:20,659 --> 03:41:20,992 GREAT! 5488 03:41:20,992 --> 03:41:24,396 LOVE IT. 5489 03:41:24,396 --> 03:41:26,164 THANK YOU SO MUCH. 5490 03:41:26,164 --> 03:41:28,967 AGAIN, IT'S A GREAT HONOR TO BE 5491 03:41:28,967 --> 03:41:32,270 WITH YOU AT THE 60th ADVISORY 5492 03:41:32,270 --> 03:41:38,343 COMMITTEE ON RESEARCH ON WOMEN'S 5493 03:41:38,343 --> 03:41:38,576 HEALTH. 5494 03:41:38,576 --> 03:41:40,278 SO, ALL RIGHT. 5495 03:41:40,278 --> 03:41:41,546 I'M PRESSING THIS BUTTON, MIDDLE 5496 03:41:41,546 --> 03:41:50,722 BUTTON. 5497 03:41:50,722 --> 03:41:54,759 THESE ARE MY DISCLOSURES, AND 5498 03:41:54,759 --> 03:41:56,928 GOING FORWARD, THERE WE GO. 5499 03:41:56,928 --> 03:42:00,065 SO, I ACTUALLY STARTED THIS 5500 03:42:00,065 --> 03:42:02,067 JOURNEY INTO ALZHEIMER'S DISEASE 5501 03:42:02,067 --> 03:42:06,538 BECAUSE OF ONE WOMAN WHO 5502 03:42:06,538 --> 03:42:08,974 TRANSFORMED MY SCIENTIFIC CREEK, 5503 03:42:08,974 --> 03:42:11,042 ONE WOMAN WITH ALZHEIMER'S. 5504 03:42:11,042 --> 03:42:14,346 IT LED ME TO BEGIN TO ASK THE 5505 03:42:14,346 --> 03:42:16,614 QUESTION, WHY WOMEN ARE AT A 5506 03:42:16,614 --> 03:42:18,583 TWO-FOLD GREATER RISK FOR 5507 03:42:18,583 --> 03:42:19,184 DEVELOPING ALZHEIMER'S DISEASE 5508 03:42:19,184 --> 03:42:20,385 AND TYPICALLY THE THOUGHT WAS 5509 03:42:20,385 --> 03:42:22,120 IT'S BECAUSE WOMEN LIVE ON 5510 03:42:22,120 --> 03:42:25,423 AVERAGE 4.5 YEARS LONGER THAN 5511 03:42:25,423 --> 03:42:25,623 MEN. 5512 03:42:25,623 --> 03:42:27,492 AND WHAT OUR RESEARCH I'LL GIVE 5513 03:42:27,492 --> 03:42:32,998 YOU THE CLIFF NOTES VERSION, OUR 5514 03:42:32,998 --> 03:42:35,967 RESEARCH HAS SHOWN THAT THE 5515 03:42:35,967 --> 03:42:37,702 RATIONALE FOR OUR DISCOVERY 5516 03:42:37,702 --> 03:42:40,672 SCIENCE, THE AVERAGE AGE OF 5517 03:42:40,672 --> 03:42:41,906 DIAGNOSIS FOR ALZHEIMER'S 5518 03:42:41,906 --> 03:42:45,176 DISEASE IS 70 TO 75, WE KNOW 5519 03:42:45,176 --> 03:42:49,214 THERE'S A 20-YEAR PRODROMAL 5520 03:42:49,214 --> 03:42:51,516 PHASE, AND DOING THAT MATH YOU 5521 03:42:51,516 --> 03:42:55,120 RUN INTO THE MENOPAUSAL 5522 03:42:55,120 --> 03:42:56,654 TRANSITION. 5523 03:42:56,654 --> 03:42:58,289 AND IT WAS THAT DISCOVERY, NOT 5524 03:42:58,289 --> 03:43:00,258 THAT DISCOVERY BUT THAT 5525 03:43:00,258 --> 03:43:01,793 RECOGNITION THAT BEGAN THIS 5526 03:43:01,793 --> 03:43:03,228 JOURNEY OF TRYING TO UNDERSTAND 5527 03:43:03,228 --> 03:43:06,297 HOW THE BRAIN IS CHANGING DURING 5528 03:43:06,297 --> 03:43:07,832 THIS MENOPAUSAL TRANSITION AND 5529 03:43:07,832 --> 03:43:09,834 THE OUTCOMES OF THAT RESEARCH 5530 03:43:09,834 --> 03:43:11,903 SHOW IT'S WOMEN AT GREATER RISK 5531 03:43:11,903 --> 03:43:12,637 FOR DEVELOPING ALZHEIMER'S 5532 03:43:12,637 --> 03:43:15,040 DISEASE NOT BECAUSE THEY LIVE 5533 03:43:15,040 --> 03:43:17,008 LONGER, BUT BECAUSE THE DISEASE 5534 03:43:17,008 --> 03:43:17,876 CAN START EARLIER. 5535 03:43:17,876 --> 03:43:20,311 SO LET'S TAKE A LOOK AT THAT 5536 03:43:20,311 --> 03:43:20,545 PROCESS. 5537 03:43:20,545 --> 03:43:25,350 WHEN WE LOOK AT THE MENOPAUSAL 5538 03:43:25,350 --> 03:43:27,352 TRANSITION, MENOPAUSE IS LIKE 5539 03:43:27,352 --> 03:43:29,621 PUBERTY, A TRANSITION STATE. 5540 03:43:29,621 --> 03:43:32,724 WHAT WE FIND IS THAT THERE IS 5541 03:43:32,724 --> 03:43:35,060 THE BEGINNING OF A DECLINING 5542 03:43:35,060 --> 03:43:37,162 BRAIN GLUCOSE METABOLISM IN RED, 5543 03:43:37,162 --> 03:43:44,936 AND A RISE IN VARIABILITY OF 5544 03:43:44,936 --> 03:43:45,804 NEUROLOGICAL FUNCTION THAT 5545 03:43:45,804 --> 03:43:47,405 STABLEs TO ANOTHER STAKE IN 5546 03:43:47,405 --> 03:43:50,208 THE MENOPAUSE. 5547 03:43:50,208 --> 03:43:55,146 ONE OF THOSE MENOPAUSAL 5548 03:43:55,146 --> 03:43:56,147 SYMPTOMS, PRIMARILY HOT FLASHES, 5549 03:43:56,147 --> 03:44:01,586 AND OF THE 80% OF WOMEN 5550 03:44:01,586 --> 03:44:03,388 SYMPTOMATIC, THE PRIMARY SYMPTOM 5551 03:44:03,388 --> 03:44:06,958 IS HOT FLASHES, AND IT CAN 5552 03:44:06,958 --> 03:44:09,027 INCLUDE COGNITIVE DYSFUNCTION, 5553 03:44:09,027 --> 03:44:11,696 PLUS INSOMNIA, PLUS MOOD 5554 03:44:11,696 --> 03:44:13,631 CHANGES, AND FOR SOME WOMEN 5555 03:44:13,631 --> 03:44:20,538 DEPRESSION AND IN SOME INSTANCES 5556 03:44:20,538 --> 03:44:22,540 SUICIDAL IDEATION, AND OBVIOUSLY 5557 03:44:22,540 --> 03:44:24,375 COMBINATION OF THE THREE. 5558 03:44:24,375 --> 03:44:26,778 SO NONE OF THESE SYMPTOMS HAVE 5559 03:44:26,778 --> 03:44:29,848 ANYTHING TO DO, INCLUDING THE 5560 03:44:29,848 --> 03:44:33,184 HOT FLASH, HAVE ANYTHING TO DO 5561 03:44:33,184 --> 03:44:35,720 WITH MENOPAUSE PER SE, BUT WITH 5562 03:44:35,720 --> 03:44:39,657 THE CHANGES THAT ARE OCCURRING 5563 03:44:39,657 --> 03:44:41,426 IN THE BRAIN. 5564 03:44:41,426 --> 03:44:43,061 SO, WHEN WE BEGAN TO ASK WHY 5565 03:44:43,061 --> 03:44:45,597 THAT WAS THE CASE WE HAD TO 5566 03:44:45,597 --> 03:44:46,764 STUDY ESTROGEN. 5567 03:44:46,764 --> 03:44:48,433 I CALL ESTROGEN THE QUEEN OF 5568 03:44:48,433 --> 03:44:48,700 DARWIN. 5569 03:44:48,700 --> 03:44:52,170 SHE HAS LEFT NOTHING TO CHANCE. 5570 03:44:52,170 --> 03:44:54,572 AND PART OF THAT IS REGULATING 5571 03:44:54,572 --> 03:44:56,307 GLUCOSE METABOLISM IN THE BRAIN. 5572 03:44:56,307 --> 03:44:59,410 THE BRAIN IS AN ALMOST 5573 03:44:59,410 --> 03:45:02,413 EXCLUSIVELY GLUCOSE DEPENDENT 5574 03:45:02,413 --> 03:45:07,285 ORGAN AND IS ESTROGEN REGULATES 5575 03:45:07,285 --> 03:45:13,424 20 TO 25% FROM GLUCOSE UPTAKE TO 5576 03:45:13,424 --> 03:45:14,425 GLUCOSE METABOLISM, ULTIMATELY 5577 03:45:14,425 --> 03:45:16,494 ATP GENERATION. 5578 03:45:16,494 --> 03:45:19,898 LOSS OF ESTROGEN IN TRANSITION 5579 03:45:19,898 --> 03:45:22,400 CAN BE ASSOCIATED WITH AN 5580 03:45:22,400 --> 03:45:24,602 ACTIVATION OF A STARVATION 5581 03:45:24,602 --> 03:45:25,270 RESPONSE. 5582 03:45:25,270 --> 03:45:26,237 THAT STARVATION RESPONSE ASKS 5583 03:45:26,237 --> 03:45:29,307 THE BRAIN TO FIND AN ALTERNATIVE 5584 03:45:29,307 --> 03:45:31,910 AUXILIARY FUEL IN ADDITION TO 5585 03:45:31,910 --> 03:45:33,244 GLUCOSE METABOLISM. 5586 03:45:33,244 --> 03:45:35,747 AND WE BEGAN TO ASK, THIS IS 5587 03:45:35,747 --> 03:45:36,848 DECADES OF BASIC SCIENCE 5588 03:45:36,848 --> 03:45:39,050 RESEARCH, AGAIN I WANT TO 5589 03:45:39,050 --> 03:45:40,785 EMPHASIZE THAT OUR RESEARCH HAS 5590 03:45:40,785 --> 03:45:42,921 BEEN SUPPORTED BY THE NATIONAL 5591 03:45:42,921 --> 03:45:46,291 INSTITUTE ON AGING FOR MORE THAN 5592 03:45:46,291 --> 03:45:48,226 A DECADE NOW, THEY WERE LEADERS 5593 03:45:48,226 --> 03:45:51,396 IN THE FIELD OF WOMEN'S HEALTH. 5594 03:45:51,396 --> 03:45:54,232 BRAIN HEALTH. 5595 03:45:54,232 --> 03:45:56,434 AND ESSENTIALLY WHAT WE FIND 5596 03:45:56,434 --> 03:45:59,837 THIS ACTIVATION OF A STARVATION 5597 03:45:59,837 --> 03:46:01,706 RESPONSE ENABLES THE BRAIN TO 5598 03:46:01,706 --> 03:46:06,144 USE KETONE BODIES, GOOD NEWS, 5599 03:46:06,144 --> 03:46:09,214 BAD NEWS. 5600 03:46:09,214 --> 03:46:11,749 THE BAD NEWS IS -- SORRY, I 5601 03:46:11,749 --> 03:46:12,517 SKIPPET OVER. 5602 03:46:12,517 --> 03:46:19,090 I HOPE I SKIPPED OVER A SLIDE. 5603 03:46:19,090 --> 03:46:21,059 I DON'T KNOW WHERE THAT SLIDE 5604 03:46:21,059 --> 03:46:21,459 IS. 5605 03:46:21,459 --> 03:46:25,463 BUT FOR US WE ASKED THE 5606 03:46:25,463 --> 03:46:29,801 QUESTION, WHERE IS THE BRAIN 5607 03:46:29,801 --> 03:46:30,668 ACQUIRING KETONE BODIES? 5608 03:46:30,668 --> 03:46:33,738 AND WHAT WE FOUND IS THAT THE 5609 03:46:33,738 --> 03:46:37,141 BRAIN CAN UTILIZE ITS OWN SOURCE 5610 03:46:37,141 --> 03:46:38,676 OF LIPIDS, THE WHITE MATTER OF 5611 03:46:38,676 --> 03:46:40,178 THE BRAIN. 5612 03:46:40,178 --> 03:46:43,248 AND WHAT WE FIND IS THAT DURING 5613 03:46:43,248 --> 03:46:44,449 THIS MENOPAUSAL TRANSITION, WE 5614 03:46:44,449 --> 03:46:47,252 FIND THAT THERE'S A METABOLIC 5615 03:46:47,252 --> 03:46:48,820 REPROGRAMMING IN MID-LIFE IN THE 5616 03:46:48,820 --> 03:46:51,122 MID-LIFE FEMALE BRAIN WHERE 5617 03:46:51,122 --> 03:46:53,558 THERE'S THE DECLINE OF GLUCOSE 5618 03:46:53,558 --> 03:46:57,929 METABOLISM IN THE BRAIN, AND A 5619 03:46:57,929 --> 03:47:03,534 RISE, EARLY RESPONSE TO UTILIZE 5620 03:47:03,534 --> 03:47:06,037 AMINO ACIDS, SHORT-LIVED, AT THE 5621 03:47:06,037 --> 03:47:07,672 COST EVER SYNAPTIC NEURAL 5622 03:47:07,672 --> 03:47:09,440 CIRCUIT DEVELOPMENT IN THE 5623 03:47:09,440 --> 03:47:10,308 BRAIN, UTILIZATION OF THOSE 5624 03:47:10,308 --> 03:47:11,075 AMINO ACIDS. 5625 03:47:11,075 --> 03:47:14,345 AND THEN WHAT WE FIND IS THAT 5626 03:47:14,345 --> 03:47:15,880 THERE'S A RISE, SIGNATURE, A 5627 03:47:15,880 --> 03:47:23,087 RISE OF FATTY ACID METABOLISM IN 5628 03:47:23,087 --> 03:47:24,222 THE BRAIN. 5629 03:47:24,222 --> 03:47:27,725 THAT'S ASSOCIATED WITH A CHANGE 5630 03:47:27,725 --> 03:47:29,460 IN MITOCHONDRIAL PHENOTYPE FROM 5631 03:47:29,460 --> 03:47:31,763 ESTROGENIC PROFILE OF HIGHLY 5632 03:47:31,763 --> 03:47:33,965 EFFICIENT MITOCHONDRIA THAT IS 5633 03:47:33,965 --> 03:47:39,137 DEPENDENT UTILIZATION OF GLUCOSE 5634 03:47:39,137 --> 03:47:42,740 TO NOW THE METABOLISM OF FATTY 5635 03:47:42,740 --> 03:47:44,909 ACIDS AND BETA OXIDATION, AND 5636 03:47:44,909 --> 03:47:49,047 THAT IS ASSOCIATED WITH 5637 03:47:49,047 --> 03:47:49,914 INEFFICIENT MITOCHONDRIA, AND 5638 03:47:49,914 --> 03:47:53,651 THAT IS PARALLELED BY A RISE IN 5639 03:47:53,651 --> 03:47:54,852 KETONE BODIES. 5640 03:47:54,852 --> 03:47:57,288 NOW ESSENTIALLY ADAPT TO THIS 5641 03:47:57,288 --> 03:47:58,356 REDUCTION IN GLUCOSE METABOLISM. 5642 03:47:58,356 --> 03:48:00,758 SO, WHAT IS THE SOURCE OF THE 5643 03:48:00,758 --> 03:48:03,361 KETONE BODIES TO FUEL A STARVING 5644 03:48:03,361 --> 03:48:03,861 BRAIN? 5645 03:48:03,861 --> 03:48:07,131 THE BRAIN IS THE MOST LIPIDDATED 5646 03:48:07,131 --> 03:48:09,100 JOGGER BEGAN OF THE BODY, 60% OF 5647 03:48:09,100 --> 03:48:10,301 BRAIN WEIGHT IS WHITE MATTER 5648 03:48:10,301 --> 03:48:14,138 OTHER LIPID WEIGHT. 5649 03:48:14,138 --> 03:48:18,409 THIS IS THE SOURCE OF THE KETONE 5650 03:48:18,409 --> 03:48:23,214 BODIES THAT ARE BEING GENERATED 5651 03:48:23,214 --> 03:48:24,449 IN THE BRAIN. 5652 03:48:24,449 --> 03:48:27,051 THIS IS A RATHER SHORT VERSION 5653 03:48:27,051 --> 03:48:29,253 OF MANY DECADES OF RESEARCH 5654 03:48:29,253 --> 03:48:30,988 MECHANISTIC RESEARCH, AND WHAT 5655 03:48:30,988 --> 03:48:34,592 WE FIND IS THAT AS I MENTIONED 5656 03:48:34,592 --> 03:48:37,228 NEURONS SEND OUT STARVATION 5657 03:48:37,228 --> 03:48:38,296 RESPONSE, ASTROCYTES NOW BEGIN 5658 03:48:38,296 --> 03:48:42,266 TO RESPOND TO THAT STARVATION BY 5659 03:48:42,266 --> 03:48:43,901 GENERATING KETONE BODIES THROUGH 5660 03:48:43,901 --> 03:48:45,436 BETA OXIDATION, WHERE ARE THEY 5661 03:48:45,436 --> 03:48:46,771 GETTING THAT FUEL? 5662 03:48:46,771 --> 03:48:48,039 AGAIN, THE WHITE MATTER. 5663 03:48:48,039 --> 03:48:50,675 AND THE WHITE MATTER NOW IS THE 5664 03:48:50,675 --> 03:48:54,312 SOURCE OF THE LIPIDS THAT WILL 5665 03:48:54,312 --> 03:48:57,382 BE ULTIMATELY METABOLIZED INTO 5666 03:48:57,382 --> 03:48:59,250 KETONE BODIES. 5667 03:48:59,250 --> 03:49:00,985 THE CHALLENGING NEWS IS THAT 5668 03:49:00,985 --> 03:49:05,590 THROUGH THE CATABOLISM OF WHITE 5669 03:49:05,590 --> 03:49:07,992 MATTER, MYELIN DEBRIS IS 5670 03:49:07,992 --> 03:49:10,294 GENERATED, BRINGING IN THE 5671 03:49:10,294 --> 03:49:12,697 MICROGLIA OF THE BRAIN, THESE 5672 03:49:12,697 --> 03:49:15,867 MYELIN DEBRIS IS TAKEN UP BY THE 5673 03:49:15,867 --> 03:49:18,002 MICROGLIA, AND THOSE FRAGMENTS 5674 03:49:18,002 --> 03:49:21,873 ARE THEN PRESENTED ON THE PLASMA 5675 03:49:21,873 --> 03:49:25,176 MEMBRANE OF THE MICROGLIA, AND 5676 03:49:25,176 --> 03:49:27,345 WHEN WE LOOK AT THIS RESPONSE 5677 03:49:27,345 --> 03:49:30,314 WHAT WE SEE IS CONSISTENT WITH 5678 03:49:30,314 --> 03:49:31,949 AN AUTOIMMUNE RESPONSE THAT IS 5679 03:49:31,949 --> 03:49:34,585 OCCURRING IN THE BRAIN DURING 5680 03:49:34,585 --> 03:49:36,220 THIS MENOPAUSAL TRANSITION, TO 5681 03:49:36,220 --> 03:49:38,189 THE BRAIN'S OWN WHITE MATTER. 5682 03:49:38,189 --> 03:49:41,359 NOW WHEN WE THINK ABOUT MULTIPLE 5683 03:49:41,359 --> 03:49:44,195 SCLEROSIS AS A RISK FACTOR, 95% 5684 03:49:44,195 --> 03:49:46,731 OF ALL PEOPLE WHO DEVELOP 5685 03:49:46,731 --> 03:49:51,969 MULTIPLE SCLEROSIS PAST 50 ARE 5686 03:49:51,969 --> 03:49:52,303 FEMALE. 5687 03:49:52,303 --> 03:49:55,673 SO, IN THE COURSE OF THIS, OF 5688 03:49:55,673 --> 03:50:00,178 PROGRAM OF RESEARCH, I TALKED 5689 03:50:00,178 --> 03:50:01,746 ABOUT THE CHANGE, REPROGRAMMING, 5690 03:50:01,746 --> 03:50:02,680 METABOLIC REPROGRAMMING THAT 5691 03:50:02,680 --> 03:50:03,881 GOES ON. 5692 03:50:03,881 --> 03:50:05,850 AND THE ACTIVATION OF IMMUNE 5693 03:50:05,850 --> 03:50:06,484 RESPONSE. 5694 03:50:06,484 --> 03:50:13,224 WHAT THAT REALLY LOOKS LIKE IS 5695 03:50:13,224 --> 03:50:13,558 THIS. 5696 03:50:13,558 --> 03:50:15,426 WE SEE FIRST ACTIVATION OF 5697 03:50:15,426 --> 03:50:18,629 INNATE IMMUNE SYSTEM. 5698 03:50:18,629 --> 03:50:20,898 FOLLOWED BY THE DECLINE IN 5699 03:50:20,898 --> 03:50:23,868 GLUCOSE METABOLISM SO THIS 5700 03:50:23,868 --> 03:50:26,070 ACTIVATION OF THE INNATE IMMUNE 5701 03:50:26,070 --> 03:50:29,273 SYSTEM HAPPENS IN THE EARLY 5702 03:50:29,273 --> 03:50:31,943 CHRONOLOGICAL AGING PRIOR TO END 5703 03:50:31,943 --> 03:50:33,544 CHRONOLOGICAL AGING. 5704 03:50:33,544 --> 03:50:37,248 THE DECLINE IN GLUCOSE 5705 03:50:37,248 --> 03:50:40,284 METABOLISM LEADS TO THIS 5706 03:50:40,284 --> 03:50:42,053 COMPENSATORY RESPONSE TO UTILIZE 5707 03:50:42,053 --> 03:50:45,256 BRANCHED AMINO ACIDS THAT ENABLE 5708 03:50:45,256 --> 03:50:47,191 GENERATION OF BOTH CONVERSION OF 5709 03:50:47,191 --> 03:50:49,393 BRANCHED AMINO ACIDS INTO 5710 03:50:49,393 --> 03:50:52,129 GLUCOSE OR KETONE BODIES, 5711 03:50:52,129 --> 03:50:54,065 SHORT-LIVED, WHILE THE SECOND 5712 03:50:54,065 --> 03:50:59,337 SYSTEM COMES ON AND DECLINE IN 5713 03:50:59,337 --> 03:51:02,440 THE MITOCHONDRIAL EFFICIENCY, 5714 03:51:02,440 --> 03:51:06,978 AND THE RISE IN THE FATTY ACID 5715 03:51:06,978 --> 03:51:11,048 BETA OXIDATION, ULTIMATELY THE 5716 03:51:11,048 --> 03:51:12,250 GENERATION OF KETONE BODIES. 5717 03:51:12,250 --> 03:51:12,450 OKAY. 5718 03:51:12,450 --> 03:51:15,853 SO, NOW WHAT WE SEE IS THAT 5719 03:51:15,853 --> 03:51:18,022 THERE ARE ACTUALLY THREE 5720 03:51:18,022 --> 03:51:19,724 PROGRAMS, TWO PROGRAMS, 5721 03:51:19,724 --> 03:51:21,192 METABOLIC REPROGRAMMING AND 5722 03:51:21,192 --> 03:51:22,860 IMMUNE ACTIVATION, THAT ARE 5723 03:51:22,860 --> 03:51:26,130 OCCURRING DURING THIS PROCESS 5724 03:51:26,130 --> 03:51:29,534 WHICH IS QUITE COMPLEX. 5725 03:51:29,534 --> 03:51:31,936 AND FINALLY, WE HAVE ACTIVATION 5726 03:51:31,936 --> 03:51:35,439 OF THE ADAPTIVE IMMUNE SYSTEM. 5727 03:51:35,439 --> 03:51:39,944 EACH OF THESE SYSTEMS ARE 5728 03:51:39,944 --> 03:51:44,949 CONSISTENT WITH A PROFILE IN 5729 03:51:44,949 --> 03:51:46,284 ALZHEIMER'S DISEASE. 5730 03:51:46,284 --> 03:51:49,220 WE ALSO FIND THAT IN FACT THE 5731 03:51:49,220 --> 03:51:55,459 HOT FLASH IS LIKELY DUE TO THE 5732 03:51:55,459 --> 03:51:59,297 ACTIVATION OF THE MICROGLIA, AND 5733 03:51:59,297 --> 03:52:02,166 THE MICROGLIA ACT AS THESE 5734 03:52:02,166 --> 03:52:05,102 NEUTROPHILS IN THE BRAIN, WHERE 5735 03:52:05,102 --> 03:52:07,838 THEY HAVE BURST OF RESPIRATORY 5736 03:52:07,838 --> 03:52:09,907 BURST TO ESSENTIALLY DESTROY A 5737 03:52:09,907 --> 03:52:12,109 FOREIGN BODY, THAT FOREIGN BODY 5738 03:52:12,109 --> 03:52:16,247 THOUGH TENDS TO BE MYELIN 5739 03:52:16,247 --> 03:52:17,582 DEBRIS. 5740 03:52:17,582 --> 03:52:19,550 SO, OUR BASIC SCIENCE RESEARCH 5741 03:52:19,550 --> 03:52:21,085 REALLY HAS INDICATED THAT THE 5742 03:52:21,085 --> 03:52:23,721 HOT FLASH IS REALLY BECAUSE OF 5743 03:52:23,721 --> 03:52:26,457 THE INEFFICIENT MITOCHONDRIA AND 5744 03:52:26,457 --> 03:52:28,526 NOW THERE'S PROTON LEAK WITHIN 5745 03:52:28,526 --> 03:52:31,929 THE BRAIN THAT'S GENERATING HEAT 5746 03:52:31,929 --> 03:52:34,432 WITHIN THE BRAIN. 5747 03:52:34,432 --> 03:52:37,735 AND THAT IS ASSOCIATED WITH 5748 03:52:37,735 --> 03:52:40,671 WHITE MATTER LOSS. 5749 03:52:40,671 --> 03:52:43,741 SO, IS THERE EVIDENCE FOR 5750 03:52:43,741 --> 03:52:45,176 METABOLIC REPROGRAMMING IN THE 5751 03:52:45,176 --> 03:52:46,577 HUMAN BRAIN, THE RESEARCH I 5752 03:52:46,577 --> 03:52:48,245 SHOWED IS OUR BASIC SCIENCE 5753 03:52:48,245 --> 03:52:50,314 DISCOVERY RESEARCH AND THIS IS 5754 03:52:50,314 --> 03:52:53,951 WORK WE CONDUCTED WITH LISA 5755 03:52:53,951 --> 03:52:58,189 MOSSCONI IN THE BRAIN AGING FROM 5756 03:52:58,189 --> 03:52:58,522 NIA. 5757 03:52:58,522 --> 03:53:01,592 WE FIND THAT IN, YES, CONSISTENT 5758 03:53:01,592 --> 03:53:05,529 WITH OUR DISCOVERY DATA, WE FIND 5759 03:53:05,529 --> 03:53:11,202 THAT THERE IS DECLINING GLUCOSE 5760 03:53:11,202 --> 03:53:14,038 METABOLISM IN TEMPORAL CORTEX, 5761 03:53:14,038 --> 03:53:16,474 PRECUNEUS AND FRONT CORTEX, ALL 5762 03:53:16,474 --> 03:53:19,744 INVOLVED IN ALZHEIMER'S DISEASE. 5763 03:53:19,744 --> 03:53:26,317 WHEN WE LOOK AT CHANGES BY MRI 5764 03:53:26,317 --> 03:53:28,586 IN BRAIN STRUCTURE THERE'S 5765 03:53:28,586 --> 03:53:30,021 AGE-ASSOCIATED DIFFERENCES IN 5766 03:53:30,021 --> 03:53:31,889 THE GRAY MATTER VOLUMES RELATIVE 5767 03:53:31,889 --> 03:53:33,858 TO THE AGING MALE BRAIN BUT 5768 03:53:33,858 --> 03:53:35,593 WHERE THE REAL CHANGES OCCUR ARE 5769 03:53:35,593 --> 03:53:39,296 IN THE WHITE MATTER WHICH IS 5770 03:53:39,296 --> 03:53:42,500 CONSISTENT WITH THE METABOLOMIC 5771 03:53:42,500 --> 03:53:46,737 PROFILE OF THE FEMALE INDIVIDUAL 5772 03:53:46,737 --> 03:53:47,905 WITH ALZHEIMER'S DISEASE. 5773 03:53:47,905 --> 03:53:50,474 WE THEN ASK THE QUESTION, IF 5774 03:53:50,474 --> 03:53:52,243 THIS CHANGE IN GLUCOSE 5775 03:53:52,243 --> 03:53:55,279 METABOLISM AND CHANGE IN WHITE 5776 03:53:55,279 --> 03:54:00,317 MATTER VOLUME IS ASSOCIATED WITH 5777 03:54:00,317 --> 03:54:01,652 DEPOSITION OF A CLASSIC 5778 03:54:01,652 --> 03:54:02,520 PATHOLOGY HALLMARK OF 5779 03:54:02,520 --> 03:54:03,821 ALZHEIMER'S DISEASE WE FIND 5780 03:54:03,821 --> 03:54:07,224 INDEED IT IS, THAT THERE'S 5781 03:54:07,224 --> 03:54:09,293 DEPOSITION OF BETA AMYLOID 5782 03:54:09,293 --> 03:54:11,395 PLAQUE IN THE BRAIN, COINCIDENT 5783 03:54:11,395 --> 03:54:14,031 WITH DECLINE IN GLUCOSE 5784 03:54:14,031 --> 03:54:16,867 METABOLISM AND WHITE MATTER 5785 03:54:16,867 --> 03:54:17,435 LOSS. 5786 03:54:17,435 --> 03:54:20,604 IF LOSS OF ESTROGEN INITIATES 5787 03:54:20,604 --> 03:54:22,139 MID-LIFE TRAJECTORY OF 5788 03:54:22,139 --> 03:54:22,907 VULNERABILITY, DOES MENOPAUSAL 5789 03:54:22,907 --> 03:54:24,442 HORMONE THERAPY IMPACT THE RISK 5790 03:54:24,442 --> 03:54:26,077 OF ALZHEIMER'S DISEASE? 5791 03:54:26,077 --> 03:54:28,479 CAN WE REPLACE THAT ESTROGEN 5792 03:54:28,479 --> 03:54:28,846 THERAPEUTICALLY? 5793 03:54:28,846 --> 03:54:34,185 AND THIS IS DATA SCIENCE WORK 5794 03:54:34,185 --> 03:54:38,856 FROM OUR TEAM THAT INVESTIGATED 5795 03:54:38,856 --> 03:54:40,725 THE IMPACT OF MENOPAUSAL HORMONE 5796 03:54:40,725 --> 03:54:44,128 THERAPY ON RISK OF DEVELOPING 5797 03:54:44,128 --> 03:54:44,862 MULTIPLE AGE-ASSOCIATED 5798 03:54:44,862 --> 03:54:46,363 NEURODEGENERATIVE DISEASES, AND 5799 03:54:46,363 --> 03:54:50,568 WE FIND INDEED THERE IS A NEAR 5800 03:54:50,568 --> 03:54:54,605 50% OR GREATER REDUCED RISK IN 5801 03:54:54,605 --> 03:54:55,940 DEVELOPING AGE-ASSOCIATED 5802 03:54:55,940 --> 03:54:57,441 NEURODEGENERATIVE DISEASES WITH 5803 03:54:57,441 --> 03:54:59,343 MENOPAUSAL HORMONE THERAPY, THE 5804 03:54:59,343 --> 03:55:00,411 LONGER WOMEN USE MENOPAUSAL 5805 03:55:00,411 --> 03:55:03,247 HORMONE THERAPY THE GREATER THE 5806 03:55:03,247 --> 03:55:05,116 REDUCTION IN RISK. 5807 03:55:05,116 --> 03:55:09,386 AND THIS WAS DONE IN ABOUT 5808 03:55:09,386 --> 03:55:14,759 380,000 WOMEN IN THE DATASET. 5809 03:55:14,759 --> 03:55:16,794 NOW, THIS BRINGS UP THE 5810 03:55:16,794 --> 03:55:18,796 QUESTION, BECAUSE THERE'S A LOT 5811 03:55:18,796 --> 03:55:20,531 OF CONTROVERSY AROUND MENOPAUSAL 5812 03:55:20,531 --> 03:55:23,934 HORMONE THERAPY. 5813 03:55:23,934 --> 03:55:26,170 SO, IT IS TYPICALLY GIVEN FOR 5814 03:55:26,170 --> 03:55:27,972 MENOPAUSAL SYMPTOMS. 5815 03:55:27,972 --> 03:55:31,809 AT THE AGE WHEN WOMEN EXPERIENCE 5816 03:55:31,809 --> 03:55:32,910 MENOPAUSAL SYMPTOMS. 5817 03:55:32,910 --> 03:55:35,646 HOWEVER, AT THIS POINT, THE 5818 03:55:35,646 --> 03:55:38,916 FIRST RX TREATMENT POINT HERE, 5819 03:55:38,916 --> 03:55:43,187 IS THAT GOING TO BE BENEFICIAL 5820 03:55:43,187 --> 03:55:46,590 OR DELETERIOUS OR OF NO IMPACT 5821 03:55:46,590 --> 03:55:56,066 DURING THE SECOND PART, OR LATE 5822 03:55:56,066 --> 03:55:56,634 ENDOCRINOLOGICAL TRANSITION. 5823 03:55:56,634 --> 03:55:58,803 SYMPTOMS IN PROCESS IN THE BRAIN 5824 03:55:58,803 --> 03:56:01,438 ARE QUITE DIFFERENT BASED ON 5825 03:56:01,438 --> 03:56:04,842 THIS AGING PROFILE, THE EARLY 5826 03:56:04,842 --> 03:56:06,710 ENDO, AND LATE PERIODS OF AGING. 5827 03:56:06,710 --> 03:56:08,679 THIS MAY IN FACT BE ONE OF THE 5828 03:56:08,679 --> 03:56:14,118 REASONS WHY THERE'S SO MUCH 5829 03:56:14,118 --> 03:56:14,885 CONTROVERSY AROUND MENOPAUSAL 5830 03:56:14,885 --> 03:56:17,855 HORMONE THERAPY AND THE 5831 03:56:17,855 --> 03:56:18,389 OUTCOMES. 5832 03:56:18,389 --> 03:56:20,491 WE THEN ASK IF ESTROGEN IS 5833 03:56:20,491 --> 03:56:22,560 BENEFICIAL FOR THE BRAINY DO 80% 5834 03:56:22,560 --> 03:56:25,830 OF WOMEN ELECT NOT TO RECEIVE 5835 03:56:25,830 --> 03:56:27,598 HORMONE THERAPY FOR MENOPAUSAL 5836 03:56:27,598 --> 03:56:27,998 SYMPTOMS? 5837 03:56:27,998 --> 03:56:30,334 THE SIMPLE ANSWER IS FEAR OF 5838 03:56:30,334 --> 03:56:31,969 BREAST CANCER. 5839 03:56:31,969 --> 03:56:34,839 SO IN ORDER TO PROMOTE BRAIN 5840 03:56:34,839 --> 03:56:42,046 HEALTH WE HAVE TO CONSIDER 5841 03:56:42,046 --> 03:56:44,215 BREAST HEALTH. 5842 03:56:44,215 --> 03:56:46,217 WE DEVELOPED A NUTRICEUTICAL 5843 03:56:46,217 --> 03:56:47,184 INTERVENTION, WE LEARNED FROM 5844 03:56:47,184 --> 03:56:51,155 WOMEN THAT THEY ARE GOING TO 5845 03:56:51,155 --> 03:56:53,457 OVER THE COUNTER PRODUCTS TO 5846 03:56:53,457 --> 03:56:55,559 TREAT, TO MANAGE THEIR 5847 03:56:55,559 --> 03:56:57,161 MENOPAUSAL SYMPTOMS, REGARDLESS 5848 03:56:57,161 --> 03:57:01,899 OF WHETHER THAT PRODUCT IS 5849 03:57:01,899 --> 03:57:04,735 EFFECTIVE OR SAFE. 5850 03:57:04,735 --> 03:57:06,704 WE DEVELOPED AN INTERVENTION, 5851 03:57:06,704 --> 03:57:08,572 PHYTO SERUM, THAT TARGETS 5852 03:57:08,572 --> 03:57:12,509 ESTROGEN RECEPTOR BETA IN THE 5853 03:57:12,509 --> 03:57:12,743 BRAIN. 5854 03:57:12,743 --> 03:57:14,044 NOW, ESTROGEN RECEPTOR BETA 5855 03:57:14,044 --> 03:57:16,113 WE'VE DONE DECADES OF RESEARCH 5856 03:57:16,113 --> 03:57:19,717 AND DEMONSTRATED IT IS A VERY 5857 03:57:19,717 --> 03:57:21,785 EFFECTIVE ESTROGEN RECEPTOR IN 5858 03:57:21,785 --> 03:57:25,322 THE BRAIN TO PROMOTE GLUCOSE 5859 03:57:25,322 --> 03:57:26,857 METABOLISM, REDUCE INFLAMMATION, 5860 03:57:26,857 --> 03:57:32,763 SUSTAIN ESTROGEN ACTION IN THE 5861 03:57:32,763 --> 03:57:33,764 BRAIN. 5862 03:57:33,764 --> 03:57:35,099 IT'S IMPORTANT BECAUSE FROM OUR 5863 03:57:35,099 --> 03:57:38,469 COLLEAGUES IN THE CANCER FIELD 5864 03:57:38,469 --> 03:57:40,337 WE LEARNED THAT ESTROGEN 5865 03:57:40,337 --> 03:57:42,873 RECEPTOR BETA IS ACTUALLY 5866 03:57:42,873 --> 03:57:46,143 ASSOCIATED WITH INHIBITION OF 5867 03:57:46,143 --> 03:57:47,244 BREAST CANCER DEVELOPMENT, 5868 03:57:47,244 --> 03:57:52,249 PROLIFERATION OF NORMAL BREAST 5869 03:57:52,249 --> 03:57:55,552 TISSUE, OF BREAST CANCER CELL 5870 03:57:55,552 --> 03:57:56,520 PROLIFERATION AND INHIBITS 5871 03:57:56,520 --> 03:58:02,226 BREAST CANCER CELL MIGRATION AND 5872 03:58:02,226 --> 03:58:02,493 INVASION. 5873 03:58:02,493 --> 03:58:11,135 WE HAVE THROUGH NIA FUNDING 5874 03:58:11,135 --> 03:58:14,071 CONDUCTED A PHASE 1B 2A CLINICAL 5875 03:58:14,071 --> 03:58:19,343 TRIAL OF A FORMULATION OF THREE 5876 03:58:19,343 --> 03:58:20,344 PLANT-BASED MOLECULES THAT 5877 03:58:20,344 --> 03:58:23,948 ACTIVATE, HAVE 80% SELECTIVITY 5878 03:58:23,948 --> 03:58:27,117 FOR ESTROGEN RECEPTOR BETA, AND 5879 03:58:27,117 --> 03:58:32,156 CONDUCTED THOSE ANALYSES AND 5880 03:58:32,156 --> 03:58:34,425 DETERMINED BOTH SAFETY AND 5881 03:58:34,425 --> 03:58:41,031 OPTIMAL DOSING AND SAW AN 5882 03:58:41,031 --> 03:58:42,533 INITIAL RESPONDER SET. 5883 03:58:42,533 --> 03:58:44,969 WE'RE NOW CONDUCTING TWO PHASE 2 5884 03:58:44,969 --> 03:58:46,603 CLINICAL TRIALS, THIS GIVES A 5885 03:58:46,603 --> 03:58:52,009 PROFILE OF THE WORK WE'VE 5886 03:58:52,009 --> 03:58:52,609 COMPLETED. 5887 03:58:52,609 --> 03:58:53,877 WE SHALL NOW CONDUCTING TWO 5888 03:58:53,877 --> 03:58:57,247 PHASE 2 CLINICAL TRIALS, ONE 5889 03:58:57,247 --> 03:58:59,984 TARGETING THE DECLINE IN BRAIN 5890 03:58:59,984 --> 03:59:05,990 GLUCOSE METABOLISM TO DETERMINE 5891 03:59:05,990 --> 03:59:09,927 WHETHER PHYTO SERUM PREVENT, IF 5892 03:59:09,927 --> 03:59:10,894 IT SUSTAINS GLUCOSE METABOLISM 5893 03:59:10,894 --> 03:59:13,430 THAT WOULD PUT THE BRAIN ON A 5894 03:59:13,430 --> 03:59:16,700 PATH TO SUSTAIN ITS WHITE MATTER 5895 03:59:16,700 --> 03:59:17,601 INTEGRITY AND POTENTIALLY 5896 03:59:17,601 --> 03:59:18,936 ULTIMATELY INHIBIT OR PREVENT 5897 03:59:18,936 --> 03:59:21,372 ARIZONA DISEASE. 5898 03:59:21,372 --> 03:59:26,243 AND OUR SECOND CLINICAL TRIAL HF 5899 03:59:26,243 --> 03:59:27,244 RELIEF IS TARGETING MENOPAUSAL 5900 03:59:27,244 --> 03:59:31,615 HOT FLASHES TO SUSTAIN BRAIN AND 5901 03:59:31,615 --> 03:59:33,017 BREAST HEALTH. 5902 03:59:33,017 --> 03:59:35,319 WITH THAT I WILL FINISH WITH KEY 5903 03:59:35,319 --> 03:59:45,863 CONCEPTS THAT THE MENOPAUSE IS 5904 03:59:46,330 --> 03:59:48,132 ACTUALLY A NEUROLOGICAL 5905 03:59:48,132 --> 03:59:49,333 TRANSITION, THIS TRANSITION 5906 03:59:49,333 --> 03:59:54,038 INVOLVES BOTH METABOLIC AND 5907 03:59:54,038 --> 03:59:57,741 IMMUNE SYSTEM REPROGRAMMING, AND 5908 03:59:57,741 --> 03:59:59,843 THAT MENOPAUSAL HORMONE THERAPY 5909 03:59:59,843 --> 04:00:02,012 PROMOTES HEALTHY BRAIN AGING, 5910 04:00:02,012 --> 04:00:06,216 DOES NOT REVERSE DISEASE. 5911 04:00:06,216 --> 04:00:10,120 THAT PROMOTING BRAIN AN BREAST 5912 04:00:10,120 --> 04:00:16,360 HEALTH IS FEASIBLE THROUGH 5913 04:00:16,360 --> 04:00:16,794 FORMULATION. 5914 04:00:16,794 --> 04:00:21,165 GAPS AND OPPORTUNITIES IS 5915 04:00:21,165 --> 04:00:23,467 PRECISION MENOPAUSAL THERAPY, 5916 04:00:23,467 --> 04:00:24,868 WHAT'S THE RIGHT THERAPY, 5917 04:00:24,868 --> 04:00:25,769 INTERVENTION, FOR THE RIGHT 5918 04:00:25,769 --> 04:00:31,642 WOMAN AT THE RIGHT TIME. 5919 04:00:31,642 --> 04:00:32,109 BIOMARKERS, DEVELOPING 5920 04:00:32,109 --> 04:00:33,310 BIOMARKERS OF TRANSITION STAGE 5921 04:00:33,310 --> 04:00:35,279 BEYOND CLINICAL SYMPTOMS BUT CAN 5922 04:00:35,279 --> 04:00:37,781 WE IDENTIFY WOMEN EARLY IN THIS 5923 04:00:37,781 --> 04:00:38,348 PROCESS? 5924 04:00:38,348 --> 04:00:42,286 AND WITH THAT I WILL END AND 5925 04:00:42,286 --> 04:00:45,456 GIVE RECOGNITION TO THE TEAM OF 5926 04:00:45,456 --> 04:00:46,990 SCIENTISTS AND COLLABORATORS AND 5927 04:00:46,990 --> 04:00:48,859 TO THE NATIONAL INSTITUTE ON 5928 04:00:48,859 --> 04:00:53,163 AGING FOR ALL THEIR SUPPORT OVER 5929 04:00:53,163 --> 04:00:56,333 MANY YEARS THAT ENABLING US TO 5930 04:00:56,333 --> 04:00:57,334 TRANSLATE BASIC SCIENCE 5931 04:00:57,334 --> 04:00:59,970 DISCOVERY INTO TRAJECTORIES TO 5932 04:00:59,970 --> 04:01:00,537 BOTH PREVENT AND POTENTIALLY 5933 04:01:00,537 --> 04:01:10,981 TREAT ALZHEIMER'S DISEASE. 5934 04:01:11,982 --> 04:01:14,451 THANK YOU. 5935 04:01:14,451 --> 04:01:17,488 >> NEXT SPEAKER IS DR. 5936 04:01:17,488 --> 04:01:18,155 BURNETT-BOWIE. 5937 04:01:18,155 --> 04:01:19,256 >> THANK YOU. 5938 04:01:19,256 --> 04:01:27,764 IT'S AN HONOR TO REPRESENT THE 5939 04:01:27,764 --> 04:01:28,232 SWAN STUDY. 5940 04:01:28,232 --> 04:01:31,702 THIS IS MY DISCLOSURE. 5941 04:01:31,702 --> 04:01:32,903 I SEE PATIENTS ONCE A WEEK 5942 04:01:32,903 --> 04:01:34,438 TUESDAY AFTERNOONS, THIS IS A 5943 04:01:34,438 --> 04:01:39,042 SLIDE I SHARE WITH THEM, WHICH 5944 04:01:39,042 --> 04:01:42,012 EMPHASIZES THAT WHEN WE CONSIDER 5945 04:01:42,012 --> 04:01:44,982 OSTEOPOROSIS IT'S NOT A DISEASE 5946 04:01:44,982 --> 04:01:45,649 WITHOUT CONSEQUENCE, AND THAT 5947 04:01:45,649 --> 04:01:48,919 WHEN YOU SUSTAIN A HIP FRACTURE, 5948 04:01:48,919 --> 04:01:51,455 THE IMPACT RELATED TO YEARS LOST 5949 04:01:51,455 --> 04:01:54,958 TO ILL HEALTH, DISABILITY, OR 5950 04:01:54,958 --> 04:01:58,762 EARLY DEATH, IS RELATED TO THAT 5951 04:01:58,762 --> 04:02:01,732 OF OVARIAN CANCER, WHEN YOU 5952 04:02:01,732 --> 04:02:03,367 SUSTAIN OSTEOPOROTIC FRACTURE, 5953 04:02:03,367 --> 04:02:07,538 UPPER ARM, WRIST, THIGH OR HIP, 5954 04:02:07,538 --> 04:02:11,375 THE IMPACT OF COLORECTAL CANCER. 5955 04:02:11,375 --> 04:02:13,677 SO WITH REGARD, REMEMBER WHEN I 5956 04:02:13,677 --> 04:02:24,221 FIRST SAW THIS STUDY, IN 2005, 5957 04:02:24,888 --> 04:02:26,456 TWO MILLION FRACTURES AFFECTING 5958 04:02:26,456 --> 04:02:26,890 WOMEN. 5959 04:02:26,890 --> 04:02:29,960 THAT FIRST YEAR, POST HIP 5960 04:02:29,960 --> 04:02:33,363 FRACTURE, THERE'S AN UP TO 24% 5961 04:02:33,363 --> 04:02:34,898 MORTALITY, AND UP TO 33% RISK OF 5962 04:02:34,898 --> 04:02:38,001 NO LONGER BEING ABLE TO LIVE 5963 04:02:38,001 --> 04:02:38,635 INDEPENDENTLY, AND THEREFORE 5964 04:02:38,635 --> 04:02:43,473 REALLY HAVING A CHANGE IN YOUR 5965 04:02:43,473 --> 04:02:43,974 FUNCTIONING. 5966 04:02:43,974 --> 04:02:47,177 IN 2025, TWO YEARS FROM NOW, ONE 5967 04:02:47,177 --> 04:02:49,346 YEAR FROM NOW, THE ANTICIPATION 5968 04:02:49,346 --> 04:02:54,952 IS THERE WILL BE 3 MILLION 5969 04:02:54,952 --> 04:02:56,486 OSTEOPOROTIC FRACTURES, THIS 5970 04:02:56,486 --> 04:03:00,090 SHOWS WHAT YOU DON'T WANT TO -- 5971 04:03:00,090 --> 04:03:03,694 THERE ARE VERY FEW PLATES HERE, 5972 04:03:03,694 --> 04:03:06,396 MORE RODS, MORE HOLES IN THE 5973 04:03:06,396 --> 04:03:08,065 BONE THAT CONTRIBUTE TO 5974 04:03:08,065 --> 04:03:09,166 COMPRESSION FRACTURES. 5975 04:03:09,166 --> 04:03:11,134 WHILE FOR THE LONGEST TIME 5976 04:03:11,134 --> 04:03:13,203 OSTEOPOROSIS HAS BEEN FRAMED AS 5977 04:03:13,203 --> 04:03:15,939 A DISEASE OF OLDER WHITE WOMEN, 5978 04:03:15,939 --> 04:03:17,474 IN FACT ALL RACIAL AND ETHNIC 5979 04:03:17,474 --> 04:03:19,943 GROUPS ARE IMPACTED BY 5980 04:03:19,943 --> 04:03:26,984 FRACTURES, AND IN 2025 THE 5981 04:03:26,984 --> 04:03:28,285 GREATEST RISE INDIVIDUALS WHO 5982 04:03:28,285 --> 04:03:29,186 IDENTIFY AS HISPANIC. 5983 04:03:29,186 --> 04:03:32,456 THESE ARE FINDINGS FROM THE 5984 04:03:32,456 --> 04:03:37,461 STUDY SHOWING THAT ACROSS BLACK, 5985 04:03:37,461 --> 04:03:38,795 HISPANIC, ASIAN, PACIFIC 5986 04:03:38,795 --> 04:03:40,330 ISLANDER, NATIVE AMERICAN 5987 04:03:40,330 --> 04:03:42,432 INDIVIDUALS, RISE IN FRACTURE, 5988 04:03:42,432 --> 04:03:49,172 BETWEEN 2005 IN YELLOW AND 2025 5989 04:03:49,172 --> 04:03:50,841 IN RED. 5990 04:03:50,841 --> 04:03:55,746 THESE ARE SOME IMPORTANT AND 5991 04:03:55,746 --> 04:03:57,080 OFTENTIMES NOT DISCUSSED DATA 5992 04:03:57,080 --> 04:04:00,517 THAT THE IMPACT OF WHO IS 5993 04:04:00,517 --> 04:04:02,753 IMPACTED BY FRACTURES IN WHI 5994 04:04:02,753 --> 04:04:10,560 ACROSS AGAIN A BROAD SWATH OF 5995 04:04:10,560 --> 04:04:12,195 WOMEN, NATIVE AMERICAN, ASIAN, 5996 04:04:12,195 --> 04:04:14,931 BLACK, HISPANIC OR WHITE, THAT 5997 04:04:14,931 --> 04:04:16,233 THE NUMBER OF FRACTURES EXCEEDS 5998 04:04:16,233 --> 04:04:19,503 THE NUMBER OF CASES OF STROKE, 5999 04:04:19,503 --> 04:04:24,341 BREAST CANCER, OR CARDIOVASCULAR 6000 04:04:24,341 --> 04:04:25,208 DISEASE. 6001 04:04:25,208 --> 04:04:28,712 BLACK WOMEN ARE NOTABLY MORE 6002 04:04:28,712 --> 04:04:32,983 LIKELY TO EXPERIENCE MORTALITY, 6003 04:04:32,983 --> 04:04:38,989 DEBILITY OR DESTITUTION, DEFINED 6004 04:04:38,989 --> 04:04:42,159 BY MEDICAID. 6005 04:04:42,159 --> 04:04:43,694 THIS MEDICARE ANALYSIS DONE 6006 04:04:43,694 --> 04:04:45,762 BETWEEN 2010 AND 2016 BY DR. 6007 04:04:45,762 --> 04:04:49,266 WRIGHT AND TEAM LOOKING AT THE 6008 04:04:49,266 --> 04:04:50,233 DIFFERENT FRACTURE TYPES, TEXT 6009 04:04:50,233 --> 04:04:51,702 IS SMALL. 6010 04:04:51,702 --> 04:04:55,172 THIS IS FEMUR, THIS IS HIP, 6011 04:04:55,172 --> 04:04:55,405 HUMERUS. 6012 04:04:55,405 --> 04:04:57,240 YOU SEE IN COMPARISON TO WHITE 6013 04:04:57,240 --> 04:04:59,543 WOMEN, BLACK WOMEN ARE ON THIS 6014 04:04:59,543 --> 04:05:02,479 SIDE OF THE LINE, INCREASED RISK 6015 04:05:02,479 --> 04:05:07,551 OF ALL THESE PROBLEMATIC 6016 04:05:07,551 --> 04:05:07,918 OUTCOMES. 6017 04:05:07,918 --> 04:05:11,822 IF THE GOAL IS TO PREVENT 6018 04:05:11,822 --> 04:05:15,659 OSTEOPOROSIS OR FRACTURE HOW 6019 04:05:15,659 --> 04:05:17,294 DOES TRANSITION IMPACT BONE 6020 04:05:17,294 --> 04:05:20,130 LOSS, ARE THERE RACIAL OR ETHNIC 6021 04:05:20,130 --> 04:05:22,399 DEFERENCES IN BONE LOSS? 6022 04:05:22,399 --> 04:05:24,401 IT'S MY PRIVILEGE TO BE HERE 6023 04:05:24,401 --> 04:05:26,470 BECAUSE THE SWAN STUDY, STUDY OF 6024 04:05:26,470 --> 04:05:28,105 WOMEN'S HEALTH ACROSS ALL 6025 04:05:28,105 --> 04:05:31,408 NATIONS, IT STARTED BECAUSE OF 6026 04:05:31,408 --> 04:05:35,645 THE INCREDIBLE ADVOCACY OF DR. 6027 04:05:35,645 --> 04:05:38,281 VIVIAN PINN, OFFICE OF RESERVE 6028 04:05:38,281 --> 04:05:41,451 ON WOMEN'S HEALTH, AND AMAZING 6029 04:05:41,451 --> 04:05:43,387 LEADSERS LIKE DR. SHERMAN AND 6030 04:05:43,387 --> 04:05:47,023 DR. DUTTA TO SAY IN EARLY 6031 04:05:47,023 --> 04:05:48,892 1990s THERE WAS NO 6032 04:05:48,892 --> 04:05:50,560 LONGITUDINAL DATA RELATED TO 6033 04:05:50,560 --> 04:05:51,962 WHAT HAPPENS WITH MENOPAUSE. 6034 04:05:51,962 --> 04:05:54,798 AND THAT IT'S NEEDED TO BE A 6035 04:05:54,798 --> 04:05:55,699 REPRESENTATIVE SAMPLE OF WOMEN 6036 04:05:55,699 --> 04:05:58,101 BOTH FROM A RACE/ETHNICITY 6037 04:05:58,101 --> 04:06:00,937 PERSPECTIVE, BUT ALSO FROM 6038 04:06:00,937 --> 04:06:02,672 SOCIOECONOMIC PERSPECTIVE, WITH 6039 04:06:02,672 --> 04:06:06,510 THE GOAL IN SWAN LONGITUDINAL 6040 04:06:06,510 --> 04:06:07,911 EPIDEMIOLOGIC STUDY TO 6041 04:06:07,911 --> 04:06:09,246 UNDERSTAND PHYSICAL, BIOLOGICAL, 6042 04:06:09,246 --> 04:06:11,982 PSYCHOLOGICAL AND SOCIAL CHANGES 6043 04:06:11,982 --> 04:06:16,486 DURING THE TRANSITIONAL PERIOD. 6044 04:06:16,486 --> 04:06:19,523 SO, IN 1994, THE PLANNING 6045 04:06:19,523 --> 04:06:21,825 STARTED, AND IN THESE SEVEN 6046 04:06:21,825 --> 04:06:24,494 SITES ACROSS THE EAST COAST, 6047 04:06:24,494 --> 04:06:33,437 MIDWEST, WEST COAST, WE 6048 04:06:33,437 --> 04:06:35,872 ULTIMATELY ENROLLED 3302 WOMEN, 6049 04:06:35,872 --> 04:06:37,174 COMMUNITY BASED SAMPLING, 6050 04:06:37,174 --> 04:06:39,943 INVITED WITH ZIP CODES, RANDOM 6051 04:06:39,943 --> 04:06:42,679 SELECTION, INVITATION TO JOIN 6052 04:06:42,679 --> 04:06:52,289 SWAN AT EACH SITE HALF COHORT 6053 04:06:52,289 --> 04:06:57,027 WHITE, YOU SEE AS OF 20 -- OR 6054 04:06:57,027 --> 04:06:59,429 15, WHICH IS OUR PENULTIMATE 6055 04:06:59,429 --> 04:07:02,666 LAST FULL VISIT WE'VE JUST 6056 04:07:02,666 --> 04:07:07,404 COMPLETED VISIT 17 WITHIN THE 6057 04:07:07,404 --> 04:07:09,406 PANDEMIC, WHICH WAS LEARNING HOW 6058 04:07:09,406 --> 04:07:13,510 TO PIVOT WE'VE HAD 75% RETENTION 6059 04:07:13,510 --> 04:07:17,280 OF THE COHORT UP TO 15, AND SOME 6060 04:07:17,280 --> 04:07:20,116 KEY ASPECTS OF SWAN, SO SWAN IS 6061 04:07:20,116 --> 04:07:25,422 A STUDY WHERE THE GOAL WAS TO 6062 04:07:25,422 --> 04:07:28,091 UNDERSTAND BOTH THE TIMING OF 6063 04:07:28,091 --> 04:07:30,827 THAT FINAL MENSTRUAL PERIOD AND 6064 04:07:30,827 --> 04:07:32,596 THEN AFTER THAT THE ABILITY TO 6065 04:07:32,596 --> 04:07:35,198 LOOK AT THE CHANGES THAT 6066 04:07:35,198 --> 04:07:37,834 HAPPENED IN MID-LIFE AND WITH 6067 04:07:37,834 --> 04:07:39,669 MENOPAUSE TRANSITION AND HOW DID 6068 04:07:39,669 --> 04:07:44,341 THOSE CHANGES THEN INFORM LATER 6069 04:07:44,341 --> 04:07:44,608 LIFE. 6070 04:07:44,608 --> 04:07:50,547 SO, TO BE ELIGIBLE YOU HAVE TO 6071 04:07:50,547 --> 04:07:53,783 SELF-IDENTIFY, BE BETWEEN 42 AND 6072 04:07:53,783 --> 04:07:58,288 52, AT LEAST ONE OVARY, INTACT 6073 04:07:58,288 --> 04:08:00,023 UTERUS, NOT USING ART BECAUSE OF 6074 04:08:00,023 --> 04:08:01,458 THE GOAL TO IDENTIFY FINAL 6075 04:08:01,458 --> 04:08:02,325 MENSTRUAL PERIOD, HAVING A 6076 04:08:02,325 --> 04:08:07,397 PERIOD IN THE LAST THREE MONTHS. 6077 04:08:07,397 --> 04:08:10,767 AND THAT WAS ELIGIBILITY. 6078 04:08:10,767 --> 04:08:14,471 THIS IS JUST ONE OF THE AGAIN 6079 04:08:14,471 --> 04:08:15,205 HUNDREDS OF PUBLICATIONS THAT 6080 04:08:15,205 --> 04:08:17,374 HAVE COME FROM SWAN. 6081 04:08:17,374 --> 04:08:20,644 I'M A PROUD BONE HEAD, SO THE 6082 04:08:20,644 --> 04:08:22,412 IMPACT OF SWAN ON OUR 6083 04:08:22,412 --> 04:08:24,581 UNDERSTANDING OF BONE LOSS HAS 6084 04:08:24,581 --> 04:08:25,916 BEEN CONSIDERABLE. 6085 04:08:25,916 --> 04:08:29,419 WE -- I'LL SHOW A FEW HIGHLIGHTS 6086 04:08:29,419 --> 04:08:31,154 AND SUBSEQUENT SLIDES, BUT THIS 6087 04:08:31,154 --> 04:08:37,160 TIME PERIOD CALLED THE 6088 04:08:37,160 --> 04:08:44,034 TRANSMENOPAUSE, WHICH IS ONE 6089 04:08:44,034 --> 04:08:50,407 YEAR, AND TWO YEARS AFTER FMP, 6090 04:08:50,407 --> 04:08:51,374 CHANGES WITH REGARD TO BONE 6091 04:08:51,374 --> 04:08:55,345 DENSE SHY. 6092 04:08:55,345 --> 04:08:56,146 DENSITY. 6093 04:08:56,146 --> 04:08:59,816 CHANGES WITH ABSORPTION AND 6094 04:08:59,816 --> 04:09:00,383 HORMONES, ESTRADIOL, PRECEDE 6095 04:09:00,383 --> 04:09:02,852 WHAT HAPPENS WITH BONE DENSITY. 6096 04:09:02,852 --> 04:09:07,791 SO WITH REGARD TO THE CHANGE IN 6097 04:09:07,791 --> 04:09:12,295 BONE DENSITY, FROM SWAN, OF OUR 6098 04:09:12,295 --> 04:09:15,599 SEVEN SITES, WE HAVE DATA, BONE 6099 04:09:15,599 --> 04:09:16,800 COHORT FROM FIVE SITES, 6100 04:09:16,800 --> 04:09:18,201 UNFORTUNATELY NOT FROM OUR 6101 04:09:18,201 --> 04:09:20,470 LATINA WOMEN. 6102 04:09:20,470 --> 04:09:24,107 BONE DENSITY WAS ASSESSED USING 6103 04:09:24,107 --> 04:09:26,509 DEXA, ALLOWING US TO ASSESS BODY 6104 04:09:26,509 --> 04:09:29,179 COMPOSITION, I BRING THIS UP NOW 6105 04:09:29,179 --> 04:09:31,247 BECAUSE BODY MASS INDEX IS A KEY 6106 04:09:31,247 --> 04:09:33,650 ASPECT OF THE CHANGE THAT 6107 04:09:33,650 --> 04:09:36,219 HAPPENS IN BONE DENSITY. 6108 04:09:36,219 --> 04:09:40,223 BUT EVEN WITH RACE BEING A 6109 04:09:40,223 --> 04:09:42,525 SOCIAL CONSTRUCT, WE STILL WERE 6110 04:09:42,525 --> 04:09:44,694 OBSERVED VARIATION IN THE CHANGE 6111 04:09:44,694 --> 04:09:47,097 IN BONE DENSITY OVER TIME THAT 6112 04:09:47,097 --> 04:09:49,799 WAS IN ADDITION TO THE 6113 04:09:49,799 --> 04:09:53,103 RECOGNITION THAT IF YOU WERE 6114 04:09:53,103 --> 04:09:55,305 HEAVIER, HIGHER BMI, LESS LOSS. 6115 04:09:55,305 --> 04:10:00,777 I'LL SHOW ONE SLIDE FROM THAT. 6116 04:10:00,777 --> 04:10:05,281 IN THIS STUDY BY GREENDALE AND 6117 04:10:05,281 --> 04:10:08,018 TEAM I'LL FOCUS ON THE 6118 04:10:08,018 --> 04:10:08,818 CUMULATIVE 10-YEAR FINDINGS 6119 04:10:08,818 --> 04:10:10,620 HERE, TO THE VERY RIGHT OF THE 6120 04:10:10,620 --> 04:10:11,054 SCREEN. 6121 04:10:11,054 --> 04:10:19,062 BUT YOU'LL SEE AS YOU LOOK AT 6122 04:10:19,062 --> 04:10:21,264 THE DATA, IT'S ASSOCIATED WITH 6123 04:10:21,264 --> 04:10:22,265 SIGNIFICANT LOSS. 6124 04:10:22,265 --> 04:10:24,467 IF WOMEN WERE TO CONTINUE TO 6125 04:10:24,467 --> 04:10:26,936 LOSE AT THAT RATE WE WOULD BE -- 6126 04:10:26,936 --> 04:10:28,405 YOU KNOW, WE WOULD BE ON THE 6127 04:10:28,405 --> 04:10:28,938 GROUND. 6128 04:10:28,938 --> 04:10:31,141 SO THE GOOD NEWS IS IT SLOWS 6129 04:10:31,141 --> 04:10:34,878 DOWN AFTER THAT THREE TO 6130 04:10:34,878 --> 04:10:35,712 FOUR-YEAR WINDOW. 6131 04:10:35,712 --> 04:10:39,783 AND THE OTHER KEY TAKEAWAY IS 6132 04:10:39,783 --> 04:10:41,451 THAT THE FOUR GROUPS, LOSS 6133 04:10:41,451 --> 04:10:44,387 OCCURS IN ALL FOUR GROUPS, 6134 04:10:44,387 --> 04:10:47,457 THERE'S BY WAY OF EXAMPLE LESS 6135 04:10:47,457 --> 04:10:50,293 LOSS IN THE TRANSMENOPAUSE IN 6136 04:10:50,293 --> 04:10:52,262 BLACK WOMEN. 6137 04:10:52,262 --> 04:10:54,564 WE AT MGH HAVE THE OPPORTUNITY 6138 04:10:54,564 --> 04:10:59,502 TO DO A DEEPER DIVE AND OBTAIN 6139 04:10:59,502 --> 04:11:03,440 EXTREME CT OR HIGH RESOLUTION, 6140 04:11:03,440 --> 04:11:07,310 PERIPHERAL Q.C.T WHICH IMAGES 6141 04:11:07,310 --> 04:11:11,014 FOREARM AND AREA JUST ABOVE YOUR 6142 04:11:11,014 --> 04:11:11,214 ANKLE. 6143 04:11:11,214 --> 04:11:14,484 AND OUR COHORT IS WHITE AND 6144 04:11:14,484 --> 04:11:15,685 BLACK. 6145 04:11:15,685 --> 04:11:21,157 WHAT YOU SEE, IT GIVES A BIOPSY, 6146 04:11:21,157 --> 04:11:25,095 VIRTUALLY BIOPSY OF BONE. 6147 04:11:25,095 --> 04:11:27,397 WHITE PARTICIPANT HAD THINNER 6148 04:11:27,397 --> 04:11:29,766 CORTICES AS COMPARED TO OUR 6149 04:11:29,766 --> 04:11:31,768 BLACK PARTICIPANT, AND THERE 6150 04:11:31,768 --> 04:11:35,472 WERE MORE, THAT'S TRUE ALSO FOR 6151 04:11:35,472 --> 04:11:43,146 BOTH RADIUS AND TIBIA, MORE 6152 04:11:43,146 --> 04:11:44,814 HOLES IN THE TRABECULA IN THE 6153 04:11:44,814 --> 04:11:45,882 WHITE THAN BLACK PARTICIPANT. 6154 04:11:45,882 --> 04:11:47,517 WITH REGARD TO THE RELATIONSHIP 6155 04:11:47,517 --> 04:11:52,122 WITH BMI, THIS WAS A STUDY WHERE 6156 04:11:52,122 --> 04:11:55,391 WE LOOKED LONGITUDINALLY AT OUR 6157 04:11:55,391 --> 04:11:57,727 PARTICIPANTS, WITH REGARD TO 6158 04:11:57,727 --> 04:12:01,097 CHANGES IN THE DIFFERENT EXTREME 6159 04:12:01,097 --> 04:12:02,232 CT MEASURES WITH TIME. 6160 04:12:02,232 --> 04:12:05,502 AND HERE WHAT YOU SEE IS IF YOU 6161 04:12:05,502 --> 04:12:08,104 WERE IN THE LOWEST -- I'M GOING 6162 04:12:08,104 --> 04:12:10,974 TO USE ONE MEASURE, WHICH IS 6163 04:12:10,974 --> 04:12:15,979 THE -- I DON'T KNOW IF TECHNICAL 6164 04:12:15,979 --> 04:12:17,113 SUPPORT CAN ADMIT DR. SIMON, 6165 04:12:17,113 --> 04:12:20,450 HERE YOU SEE THAT IF YOU WERE IN 6166 04:12:20,450 --> 04:12:23,520 THE LOWEST -- IF YOU HAD THE 6167 04:12:23,520 --> 04:12:25,622 GREATEST LOSS OF -- IF YOU WERE 6168 04:12:25,622 --> 04:12:27,423 THE LOWEST WEIGHT TERTILE, 6169 04:12:27,423 --> 04:12:31,327 EXCUSE ME, VERSE U.S. IN THE 6170 04:12:31,327 --> 04:12:32,662 HIGHEST WEIGHT TERTILE, THAT 6171 04:12:32,662 --> 04:12:37,233 THERE WERE DIFFERENCE WHERE IS 6172 04:12:37,233 --> 04:12:39,536 YOU LOST LESS WEIGHT, OR SAID 6173 04:12:39,536 --> 04:12:41,604 DIFFERENTLY IF YOU HAVE A LOWER 6174 04:12:41,604 --> 04:12:45,675 BMI OR WEIGHT YOU HAD GREATER 6175 04:12:45,675 --> 04:12:52,248 BONE DENSITY LOSS, THE EXTREME 6176 04:12:52,248 --> 04:13:02,692 CT, IN THAT EXAMINATION. 6177 04:13:05,962 --> 04:13:08,398 SO, WITH REGARD TO CHANGES IN 6178 04:13:08,398 --> 04:13:10,700 BONE DENSITY, WITH REGARD TO THE 6179 04:13:10,700 --> 04:13:12,502 MENOPAUSE AND MID-LIFE 6180 04:13:12,502 --> 04:13:15,538 TRANSITION, THIS KEY STUDY WAS 6181 04:13:15,538 --> 04:13:19,809 DONE WHICH LOOKED AT 15 YEARS OF 6182 04:13:19,809 --> 04:13:22,645 BODY COMPOSITION DATA, THAT WERE 6183 04:13:22,645 --> 04:13:24,047 COLLECTED. 6184 04:13:24,047 --> 04:13:27,016 AND IN THIS SUBSTUDY, JUST AGAIN 6185 04:13:27,016 --> 04:13:28,751 TO POINT OUT THAT ALL OF -- WE 6186 04:13:28,751 --> 04:13:32,822 HAVE DATA, WE DON'T HAVE DATA ON 6187 04:13:32,822 --> 04:13:36,226 OUR LATINA WOMEN, BUT WOMEN WERE 6188 04:13:36,226 --> 04:13:38,628 CAPTURED FROM BASELINE AGE OF 46 6189 04:13:38,628 --> 04:13:40,496 ON AVERAGE, THEY WERE HAVING 6190 04:13:40,496 --> 04:13:43,099 THEIR FINAL MENSTRUAL PERIOD 6191 04:13:43,099 --> 04:13:44,868 ROUGHLY ABOUT SIX YEARS AFTER 6192 04:13:44,868 --> 04:13:48,371 THAT, AND YOU SEE HERE THAT 6193 04:13:48,371 --> 04:13:51,875 THERE WERE DIFFERENCES IN BMI 6194 04:13:51,875 --> 04:13:53,743 ACROSS OUR GROUPS, WITH OUR 6195 04:13:53,743 --> 04:13:57,780 BLACK WOMEN HAVING THE HIGHEST 6196 04:13:57,780 --> 04:13:59,449 BMI AT BASELINE. 6197 04:13:59,449 --> 04:14:04,254 AND THEN WITH REGARD TO WHAT 6198 04:14:04,254 --> 04:14:05,121 OCCURRED WITH THE TRANSITION, 6199 04:14:05,121 --> 04:14:10,026 I'LL WALK YOU THROUGH AND POINT 6200 04:14:10,026 --> 04:14:11,527 OUT HERE THAT THE SOLID RED 6201 04:14:11,527 --> 04:14:12,896 LINE, I'M GOING TO LOOK AT THIS 6202 04:14:12,896 --> 04:14:14,964 AND NOT TRY TO POINT THERE. 6203 04:14:14,964 --> 04:14:18,368 THE SOLID RED LINE CAPTURES THE 6204 04:14:18,368 --> 04:14:20,870 CHANGE IN BODY WEIGHT THAT 6205 04:14:20,870 --> 04:14:23,172 HAPPENED ACROSS THOSE 15 YEARS. 6206 04:14:23,172 --> 04:14:25,241 THE GRAY LINE CAPTURING THE 6207 04:14:25,241 --> 04:14:26,342 FINAL MENSTRUAL PERIOD. 6208 04:14:26,342 --> 04:14:29,512 AGAIN, I'LL JUST SHOW ON BOTTOM 6209 04:14:29,512 --> 04:14:31,047 THE TRANSMENOPAUSE IS THIS -- 6210 04:14:31,047 --> 04:14:33,449 FOR THIS ANALYSIS FROM TWO YEARS 6211 04:14:33,449 --> 04:14:35,318 BEFORE THE FMP TO TWO YEARS 6212 04:14:35,318 --> 04:14:36,419 AFTER THE FMP. 6213 04:14:36,419 --> 04:14:41,324 AND WHAT YOU SEE IS THAT THERE 6214 04:14:41,324 --> 04:14:44,394 ARE -- THERE'S A RISE ON AVERAGE 6215 04:14:44,394 --> 04:14:47,230 IN BODY WEIGHT AND BMI, CAPTURED 6216 04:14:47,230 --> 04:14:52,502 BY THE DASHED LINES OVER THAT 6217 04:14:52,502 --> 04:14:52,869 TRANSMENOPAUSE. 6218 04:14:52,869 --> 04:14:58,942 BUT YOU SEE STEEP INCREASES IN 6219 04:14:58,942 --> 04:15:01,044 YOUR FAT MASS, LESS STIP BUT 6220 04:15:01,044 --> 04:15:03,246 STILL RISING IN FAT PROPORTION 6221 04:15:03,246 --> 04:15:06,816 OF BODY COMPOSITION, THAT'S FAT, 6222 04:15:06,816 --> 04:15:13,523 AND A DECLINE IN THE LEAN MASS 6223 04:15:13,523 --> 04:15:15,258 BUT RELATIVELY GREATER DECLINE 6224 04:15:15,258 --> 04:15:18,528 IN THE PROPORTION OF LEAN WITH 6225 04:15:18,528 --> 04:15:19,862 THAT TRANSMENOPAUSAL, VERY 6226 04:15:19,862 --> 04:15:21,931 ACTIVE TIME, AND THEN A 6227 04:15:21,931 --> 04:15:24,133 PLATEAUING OF THE CHANGE ONCE 6228 04:15:24,133 --> 04:15:27,303 WOMEN ARE TWO YEARS POST 6229 04:15:27,303 --> 04:15:28,071 MENOPAUSAL. 6230 04:15:28,071 --> 04:15:30,707 HERE AGAIN, THERE WERE RACIAL 6231 04:15:30,707 --> 04:15:33,209 AND ETHNIC DIFFERENCES. 6232 04:15:33,209 --> 04:15:35,411 THE REASON WHY THIS ANALYSIS WAS 6233 04:15:35,411 --> 04:15:36,946 PARTICULARLY IMPORTANT, YOU CAN 6234 04:15:36,946 --> 04:15:39,649 IMAGINE THAT IF YOU WERE SOLELY 6235 04:15:39,649 --> 04:15:40,850 LOOKING AT THE CHANGE IN BODY 6236 04:15:40,850 --> 04:15:42,752 WEIGHT, WHICH IS WHAT WE COULD 6237 04:15:42,752 --> 04:15:44,020 DO CLINICALLY, YOU WOULD NOT 6238 04:15:44,020 --> 04:15:49,192 REALLY BE ABLE TO CAPTURE THE 6239 04:15:49,192 --> 04:15:53,096 CHANGES, NOR DECLINE IN LEAN 6240 04:15:53,096 --> 04:15:55,198 MASS PROPORTION. 6241 04:15:55,198 --> 04:15:58,034 AND THE FACT THAT OUR -- THERE 6242 04:15:58,034 --> 04:16:02,572 WERE DIFFERENCES WITH OUR 6243 04:16:02,572 --> 04:16:03,439 CHINESE WOMEN, SPECIFICALLY 6244 04:16:03,439 --> 04:16:05,508 HAVING LESS RISE IN FAT MASS, 6245 04:16:05,508 --> 04:16:09,345 AND GAIN IN LEAN MASS PROPORTION 6246 04:16:09,345 --> 04:16:15,485 AS OPPOSED TO A DECREASE SEEN IN 6247 04:16:15,485 --> 04:16:16,252 OTHER GROUPS. 6248 04:16:16,252 --> 04:16:20,857 WE STUDIED HOW CHANGES IN BODY 6249 04:16:20,857 --> 04:16:27,663 COMPOSITION, HOW THEY ARE 6250 04:16:27,663 --> 04:16:28,464 ASSOCIATED LONGITUDINALLY IN 6251 04:16:28,464 --> 04:16:29,532 BONE DENSITY AND FRACTURE. 6252 04:16:29,532 --> 04:16:32,502 WHAT WAS OBSERVED WITH LEAN MASS 6253 04:16:32,502 --> 04:16:34,971 DECLINED, THERE WAS ASSOCIATED 6254 04:16:34,971 --> 04:16:38,174 DECLINE IN FEMORAL NECK AND 6255 04:16:38,174 --> 04:16:42,011 LUMBAR SPINE BONE DENSITY, 6256 04:16:42,011 --> 04:16:44,847 SIMILARLY HIGHER FAT MASS, MORE 6257 04:16:44,847 --> 04:16:46,849 BONE DENSITY LOSS. 6258 04:16:46,849 --> 04:16:48,184 AND VERY SIMILAR PATTERNS FOR 6259 04:16:48,184 --> 04:16:51,554 LEAN MASS LOSS AND FAT MASS GAIN 6260 04:16:51,554 --> 04:16:52,989 ASSOCIATED WITH INCIDENT 6261 04:16:52,989 --> 04:17:00,296 FRACTURES AFTER THE MENOPAUSE 6262 04:17:00,296 --> 04:17:00,596 TRANSITION. 6263 04:17:00,596 --> 04:17:02,365 INTERVENTIONS CAN BE DONE. 6264 04:17:02,365 --> 04:17:10,306 THIS STUDY WAS EXCITING BECAUSE 6265 04:17:10,306 --> 04:17:12,708 WE ASSESSED OVER 17 YEARS 6266 04:17:12,708 --> 04:17:17,880 LEISURE TIME PHYSICAL ACTIVITY, 6267 04:17:17,880 --> 04:17:20,616 MOST POPULAR BEING WALKING. 6268 04:17:20,616 --> 04:17:23,086 IF YOU WERE WALKING, 6269 04:17:23,086 --> 04:17:25,388 CALISTHENICS, SWIMMING, YOU HAD 6270 04:17:25,388 --> 04:17:28,357 LESS LOSS IF YOU INCREASED YOUR 6271 04:17:28,357 --> 04:17:32,395 LEISURE TIME PHYSICAL ACTIVITY, 6272 04:17:32,395 --> 04:17:35,331 YOU ACTUALLY SLOWED THE LOSS IN 6273 04:17:35,331 --> 04:17:37,333 BMD OVER 17 YEARS, FOR THOSE AT 6274 04:17:37,333 --> 04:17:39,635 THE HIGHEST LEVEL OF LEISURE 6275 04:17:39,635 --> 04:17:42,271 TIME PHYSICAL ACTIVITY, AND THE 6276 04:17:42,271 --> 04:17:44,574 LOWEST AND HIGHEST LEVEL OF 6277 04:17:44,574 --> 04:17:46,309 LEISURE TIME PHYSICAL ACTIVITY, 6278 04:17:46,309 --> 04:17:47,844 WAS ASSOCIATED WITH HIGHEST 6279 04:17:47,844 --> 04:17:49,445 SPINE AND FEMORAL NECK BONE 6280 04:17:49,445 --> 04:17:50,513 DENSITY. 6281 04:17:50,513 --> 04:17:55,051 THIS IS A SMALL STUDY, NOT DONE 6282 04:17:55,051 --> 04:17:58,554 IN SWAN, BUT IN THESE 6283 04:17:58,554 --> 04:18:01,524 58-YEAR-OLD AND 58-YEAR-OLD PLUS 6284 04:18:01,524 --> 04:18:04,460 WOMEN, PUMPING WEIGHTS, UP TO 6285 04:18:04,460 --> 04:18:06,662 80-KILOS WITH TRAINERS. 6286 04:18:06,662 --> 04:18:08,097 AND WITH THAT, SIGNIFICANT 6287 04:18:08,097 --> 04:18:09,832 IMPROVEMENTS IN BONE DENSITY, SO 6288 04:18:09,832 --> 04:18:11,367 KEEPING IN MIND WHEN PATIENTS 6289 04:18:11,367 --> 04:18:16,105 ASK ME ABOUT WHAT CAN YOU DO 6290 04:18:16,105 --> 04:18:17,306 THAT'S NON-PHARMACOLOGICAL I 6291 04:18:17,306 --> 04:18:20,576 SHARE THIS BUT ALSO STRESS YOU 6292 04:18:20,576 --> 04:18:21,911 REQUIRE RESOURCES AS WELL AS 6293 04:18:21,911 --> 04:18:23,312 TIME AND A TRAINER TO ENSURE 6294 04:18:23,312 --> 04:18:24,080 THAT YOU'RE SAFE. 6295 04:18:24,080 --> 04:18:26,048 I WANT TO CLOSE BY SHARING THAT 6296 04:18:26,048 --> 04:18:30,019 WE DID SEE IN SWAN HIGHER 6297 04:18:30,019 --> 04:18:32,221 VITAMIN D LEVELS ASSOCIATED WITH 6298 04:18:32,221 --> 04:18:35,591 FEWER FRACTURES OVER TIME. 6299 04:18:35,591 --> 04:18:37,693 BUT CAUTIONARY NOTE THAT OURS IS 6300 04:18:37,693 --> 04:18:41,063 A TEN-YEAR ANALYSIS BUT IN THE 6301 04:18:41,063 --> 04:18:42,598 WOMEN'S -- IN THE VITAL STUDY 6302 04:18:42,598 --> 04:18:45,234 THERE WAS NOT AN INCREASE OR NOT 6303 04:18:45,234 --> 04:18:47,737 A DECREASED RISK OF FRACTURE 6304 04:18:47,737 --> 04:18:49,839 WITH VITAMIN D. 6305 04:18:49,839 --> 04:18:52,542 SO, I'M GOING TO FLASH QUICKLY. 6306 04:18:52,542 --> 04:18:56,712 THIS IS WHAT SWAN HAS SHOWN WITH 6307 04:18:56,712 --> 04:18:59,815 REGARD TO WHICH MEDICATIONS DO 6308 04:18:59,815 --> 04:19:03,186 AND DO NOT HAVE ASSOCIATED BONE 6309 04:19:03,186 --> 04:19:07,557 LOSS OR FRACTURE RISK. 6310 04:19:07,557 --> 04:19:08,858 AND I'M THINKING ABOUT WHEN YOU 6311 04:19:08,858 --> 04:19:11,360 TRY TO PUT THIS ALL TOGETHER, 6312 04:19:11,360 --> 04:19:13,763 WHAT DO WE KNOW FROM SWAN AND 6313 04:19:13,763 --> 04:19:16,999 OUR FINDINGS AT THE MID-LIFE AND 6314 04:19:16,999 --> 04:19:19,235 WITH MENOPAUSE TRANSITION, IF 6315 04:19:19,235 --> 04:19:22,205 YOU -- YOUR AGE OF FINAL 6316 04:19:22,205 --> 04:19:26,042 MENSTRUAL PERIOD IS MORE 6317 04:19:26,042 --> 04:19:27,343 IMPORTANT THAN CHRONOLOGIC AGE. 6318 04:19:27,343 --> 04:19:30,213 I SHOWED LEISURE TIME PHYSICAL 6319 04:19:30,213 --> 04:19:30,580 ACTIVITY. 6320 04:19:30,580 --> 04:19:33,950 THERE'S A STRONG ASSOCIATION 6321 04:19:33,950 --> 04:19:34,784 WITH DIABETES, PREDIABETES, 6322 04:19:34,784 --> 04:19:38,187 INSULIN RESISTANCE WITH 6323 04:19:38,187 --> 04:19:40,389 INCREASED RISK OF BONE DENSITY 6324 04:19:40,389 --> 04:19:43,893 LOSS, HIGHER BMI BEING 6325 04:19:43,893 --> 04:19:47,496 ASSOCIATED WITH LESS LOSS, BUT 6326 04:19:47,496 --> 04:19:50,099 IF YOU HAVE HIGHER FAT MASS 6327 04:19:50,099 --> 04:19:51,767 THAT'S ASSOCIATED WITH AN 6328 04:19:51,767 --> 04:19:56,239 INCREASED RISK OF LOSS, IT'S 6329 04:19:56,239 --> 04:19:57,506 POSSIBLE THAT IT IS THE -- WE 6330 04:19:57,506 --> 04:20:02,044 BOTH DID THAT AT THE SAME TIME. 6331 04:20:02,044 --> 04:20:04,013 THAT MAYBE IT IS THE 6332 04:20:04,013 --> 04:20:05,681 PRE-INFLAMMATION ASSOCIATED WITH 6333 04:20:05,681 --> 04:20:07,984 HIGHER FAT MASS THAT MIGHT 6334 04:20:07,984 --> 04:20:08,851 EXPLAIN THESE FINDINGS IN TERMS 6335 04:20:08,851 --> 04:20:10,586 OF WHY PATIENTS WHO HAVE 6336 04:20:10,586 --> 04:20:14,423 DIABETES HAVE MORE BONE DENSITY 6337 04:20:14,423 --> 04:20:15,191 LOSS. 6338 04:20:15,191 --> 04:20:17,260 SO, COMING TO MY LAST SLIDE, 6339 04:20:17,260 --> 04:20:19,662 WHAT IS UNKNOWN, WE DON'T KNOW 6340 04:20:19,662 --> 04:20:21,430 HOW THIS LOSS AT MID-LIFE 6341 04:20:21,430 --> 04:20:22,632 INFORMS BONE LOSS IN LATER 6342 04:20:22,632 --> 04:20:26,102 YEARS, SOMETHING WE'RE HOPING TO 6343 04:20:26,102 --> 04:20:27,770 STUDY WITHIN SWAN AGING. 6344 04:20:27,770 --> 04:20:31,040 CAN WE PREDICT WHO WILL FRACTURE 6345 04:20:31,040 --> 04:20:34,010 OR HAVE ACCELERATED BONE LOSS IN 6346 04:20:34,010 --> 04:20:36,279 LATER LIFE BASED ON EITHER BONE 6347 04:20:36,279 --> 04:20:37,513 DENSITY AT MID-LIFE OR OTHER 6348 04:20:37,513 --> 04:20:41,150 CHANGES IN THE MID-LIFE OR 6349 04:20:41,150 --> 04:20:41,617 MENOPAUSE TRANSITION? 6350 04:20:41,617 --> 04:20:44,186 CLINICALLY IF A WOMAN HAS NOT 6351 04:20:44,186 --> 04:20:48,457 FRACTURED BUT HAS OSTEOPENIA 6352 04:20:48,457 --> 04:20:50,226 RISK WHEN SHOULD PROSCRIPTION 6353 04:20:50,226 --> 04:20:50,993 MEDICATION BE INITIATED? 6354 04:20:50,993 --> 04:20:53,729 IN PARTICULAR FOR WOMEN WHO HAVE 6355 04:20:53,729 --> 04:20:58,567 OR ARE PAST TIMING OF ANY 6356 04:20:58,567 --> 04:21:00,736 POTENTIAL CONSIDERATION OF HRT, 6357 04:21:00,736 --> 04:21:02,805 AND AS WILL BE HIGHLIGHTED IN A 6358 04:21:02,805 --> 04:21:05,007 FINAL SLIDE HRT IS NO LONGER 6359 04:21:05,007 --> 04:21:08,044 LISTED BY THE OFFICE OF WOMEN'S 6360 04:21:08,044 --> 04:21:09,679 HEALTH AS A TREATMENT 6361 04:21:09,679 --> 04:21:11,113 CONSIDERATION FOR PATIENTS WITH 6362 04:21:11,113 --> 04:21:12,181 OSTEOPOROSIS AND WHAT CAN BE 6363 04:21:12,181 --> 04:21:14,617 DONE AT THE MID-LIFE TO REDUCE 6364 04:21:14,617 --> 04:21:16,252 THOSE RACIAL AND ETHNIC 6365 04:21:16,252 --> 04:21:17,653 DISPARITIES THAT I SHOWED. 6366 04:21:17,653 --> 04:21:21,624 I DOWNLOADED THIS AND I LOVE 6367 04:21:21,624 --> 04:21:22,925 THAT THERE'S PATIENT-FACING 6368 04:21:22,925 --> 04:21:24,460 MATERIAL OF SO MANY KINDS. 6369 04:21:24,460 --> 04:21:32,034 AND THIS IS WHAT IS LISTED FOR 6370 04:21:32,034 --> 04:21:32,902 PRESCRIPTION MEDICATIONS FOR 6371 04:21:32,902 --> 04:21:34,770 OSTEOPOROSIS THE NIH WEBSITE. 6372 04:21:34,770 --> 04:21:37,373 I WANT TO THANK -- AND THIS IS A 6373 04:21:37,373 --> 04:21:40,309 FRACTION OF THE NUMBER OF 6374 04:21:40,309 --> 04:21:44,146 INVESTIGATORS WITHIN SWAN, I 6375 04:21:44,146 --> 04:21:50,519 HIGHLIGHT HERE MY COLLEAGUES. 6376 04:21:50,519 --> 04:21:53,456 THESE ARE THE CURRENT AND PAST 6377 04:21:53,456 --> 04:21:55,291 RESEARCH COORDINATORS, WE TALKED 6378 04:21:55,291 --> 04:21:58,160 ABOUT MENTORSHIP, ALL OF THESE 6379 04:21:58,160 --> 04:22:00,496 AMAZING YOUNG WOMEN ARE EITHER 6380 04:22:00,496 --> 04:22:02,264 PHYSICIANS OR ON THEIR WAY, AND 6381 04:22:02,264 --> 04:22:05,968 SO THANK YOU FOR THE FUNDING AND 6382 04:22:05,968 --> 04:22:07,403 OF COURSE INCREDIBLE FUNDING 6383 04:22:07,403 --> 04:22:08,571 THAT SWAN HAS HAD OVER THE 6384 04:22:08,571 --> 04:22:08,771 YEARS. 6385 04:22:08,771 --> 04:22:11,741 THANK YOU FOR YOUR ATTENTION. 6386 04:22:11,741 --> 04:22:17,780 6387 04:22:17,780 --> 04:22:20,616 6388 04:22:20,616 --> 04:22:29,291 >> DR. HODIS, PLEASE. 6389 04:22:29,291 --> 04:22:39,235 6390 04:22:39,235 --> 04:22:41,137 I'D LIKE TO THANK DR. CLAYTON 6391 04:22:41,137 --> 04:22:46,175 AND DR. OTA WANG AND DR. DUTTA 6392 04:22:46,175 --> 04:22:47,143 FOR THE INVITATION. 6393 04:22:47,143 --> 04:22:51,213 IT'S A PRIVILEGE TO BE HERE. 6394 04:22:51,213 --> 04:22:54,049 THIS IS OUR CURRENT FUNDING. 6395 04:22:54,049 --> 04:22:56,218 AND LIKE THE TWO PREVIOUS 6396 04:22:56,218 --> 04:22:57,887 SPEAKERS, I'M GOING TO SHOW WORK 6397 04:22:57,887 --> 04:23:00,289 TODAY THAT COULD HAVE NEVER BEEN 6398 04:23:00,289 --> 04:23:03,926 ACCOMPLISHED WITHOUT THE HELP OF 6399 04:23:03,926 --> 04:23:06,128 NIH AND THE PART OF OUR PROGRAM 6400 04:23:06,128 --> 04:23:10,699 I'M GOING TO DISCUSS TODAY WHICH 6401 04:23:10,699 --> 04:23:14,470 DOVETAILS WITH WOMEN'S HEALTH, 6402 04:23:14,470 --> 04:23:15,337 PREDOMINANTLY FUNDED THROUGH 6403 04:23:15,337 --> 04:23:15,738 NIA. 6404 04:23:15,738 --> 04:23:19,375 AS YOU HEARD TODAY ALREADY, 6405 04:23:19,375 --> 04:23:21,143 CARDIOVASCULAR DISEASE IS 6406 04:23:21,143 --> 04:23:22,878 LEADING CAUSE OF DEATH IN WOMEN, 6407 04:23:22,878 --> 04:23:28,050 CONTINUES TO RISE, CONTINUES TO 6408 04:23:28,050 --> 04:23:29,251 BE A PROBLEM. 6409 04:23:29,251 --> 04:23:31,987 VAST MAJORITY OF WOMEN WHO DIE 6410 04:23:31,987 --> 04:23:33,322 FROM CARDIOVASCULAR DISEASE DO 6411 04:23:33,322 --> 04:23:37,460 SO IN POST MENOPAUSAL PERIOD. 6412 04:23:37,460 --> 04:23:40,095 VERY FEW WOMEN DIE IN 6413 04:23:40,095 --> 04:23:46,101 PRE-MENOPAUSAL PERIOD FROM 6414 04:23:46,101 --> 04:23:46,869 CARDIOVASCULAR DISEASE. 6415 04:23:46,869 --> 04:23:50,372 50 OR SO YEARS AGO, ACROSS THE 6416 04:23:50,372 --> 04:23:52,641 ENTIRE AGE RANGE, POST 6417 04:23:52,641 --> 04:23:54,543 MENOPAUSAL WOMEN ARE TWO TO 6418 04:23:54,543 --> 04:23:56,512 SIX-FOLD GREATER RISK FOR 6419 04:23:56,512 --> 04:24:00,316 CORONARY HEART DISEASE THAN 6420 04:24:00,316 --> 04:24:01,650 PRE-MENOPAUSAL WOMEN. 6421 04:24:01,650 --> 04:24:03,185 WITH THIS, THE QUESTION IS WHO 6422 04:24:03,185 --> 04:24:09,959 ARE THE WOMEN MOST LIKELY TO BE 6423 04:24:09,959 --> 04:24:10,359 PROTECTED? 6424 04:24:10,359 --> 04:24:13,128 WELL, 40 YEARS -- APPROXIMATELY 6425 04:24:13,128 --> 04:24:16,298 40 YEARS AND DOZENS OF 6426 04:24:16,298 --> 04:24:19,602 OBSERVATIONAL STUDIES HAVE 6427 04:24:19,602 --> 04:24:21,570 POINTED OUT THAT WOMEN WHO 6428 04:24:21,570 --> 04:24:23,205 SELECT FOR HORMONE THERAPY HAVE 6429 04:24:23,205 --> 04:24:24,106 REDUCTION IN CORONARY HEART 6430 04:24:24,106 --> 04:24:29,111 DISEASE, THIS IS TRUE FOR 6431 04:24:29,111 --> 04:24:31,514 ALL-CAUSE MORTALITY. 6432 04:24:31,514 --> 04:24:32,948 LARGE RANDOMIZED TRIALS, HAVE 6433 04:24:32,948 --> 04:24:36,118 SHOWED A NULL EFFECT, WOMEN 6434 04:24:36,118 --> 04:24:40,389 RANDOMIZED TO HORMONE THERAPY. 6435 04:24:40,389 --> 04:24:41,156 VERSUS PLACEBO. 6436 04:24:41,156 --> 04:24:43,893 WITH INSTRUCTIONS TO LOOK AT WHY 6437 04:24:43,893 --> 04:24:50,299 THERE IS THIS DIFFERENCE. 6438 04:24:50,299 --> 04:24:51,867 HYPOTHESIS BASED ON 6439 04:24:51,867 --> 04:24:53,602 OBSERVATIONAL STUDIES SHOWN 6440 04:24:53,602 --> 04:24:55,704 HERE, COLLECTIVELY LOOKED AT THE 6441 04:24:55,704 --> 04:25:00,943 AGES OF WOMEN, TIME FOR 6442 04:25:00,943 --> 04:25:02,811 MENOPAUSE, PRE-SELECTED HORMONE 6443 04:25:02,811 --> 04:25:04,680 THERAPY, PREDOMINANTLY HAD 6444 04:25:04,680 --> 04:25:05,314 MENOPAUSAL SYMPTOMS, RANDOMIZED 6445 04:25:05,314 --> 04:25:08,083 TRIALS HAVE BEEN MUCH OLDER 6446 04:25:08,083 --> 04:25:11,153 WOMEN, MUCH FURTHER FROM 6447 04:25:11,153 --> 04:25:16,625 MENOPAUSE, EXCLUDED AS BEST AS 6448 04:25:16,625 --> 04:25:17,459 POSSIBLE, MENOPAUSAL RELATED 6449 04:25:17,459 --> 04:25:21,630 SYMPTOMS AND YOU CAN SEE THESE 6450 04:25:21,630 --> 04:25:29,204 ARE TWO DIFFERENT POPULATIONS OF 6451 04:25:29,204 --> 04:25:29,505 WOMEN. 6452 04:25:29,505 --> 04:25:34,577 EARLY ON THIS IDEA OF TIMING, AS 6453 04:25:34,577 --> 04:25:37,746 YOU HEARD FROM ROBBIE, IT WAS 6454 04:25:37,746 --> 04:25:42,017 HYPOTHESIZED THE EFFECT OF 6455 04:25:42,017 --> 04:25:43,152 MENOPAUSE HORMONE THERAPY ON 6456 04:25:43,152 --> 04:25:45,387 ATHEROSCLEROSIS, WHERE WE WERE 6457 04:25:45,387 --> 04:25:47,489 COMING FROM, AS CLINICAL 6458 04:25:47,489 --> 04:25:49,425 ADVANCES ARE DEPENDENT UPON WHEN 6459 04:25:49,425 --> 04:25:52,528 HORMONE THERAPY IS INITIATED IN 6460 04:25:52,528 --> 04:25:54,263 RELATION TO MENOPAUSE AND/OR 6461 04:25:54,263 --> 04:25:54,530 AGE. 6462 04:25:54,530 --> 04:25:56,231 NOT ABLE TO PARSE IT OUT YET. 6463 04:25:56,231 --> 04:25:57,967 THAT'S ONE OF THOSE THINGS THAT 6464 04:25:57,967 --> 04:26:06,408 NEEDS TO BE DONE, IS IT AGE OR 6465 04:26:06,408 --> 04:26:07,543 MENOPAUSE? 6466 04:26:07,543 --> 04:26:10,679 MANY LINES OF EVIDENCE HAVE 6467 04:26:10,679 --> 04:26:14,416 CONVERGED IN BASICALLY 6468 04:26:14,416 --> 04:26:16,018 SUPPORTING THIS HYPOTHESIS. 6469 04:26:16,018 --> 04:26:21,857 SO PRIOR TO THIS TIMING 6470 04:26:21,857 --> 04:26:25,127 HYPOTHESIS, IF YOU WILL, THE 6471 04:26:25,127 --> 04:26:26,228 ENDOTHELIUM HYPOTHESIS WAS 6472 04:26:26,228 --> 04:26:30,165 FLOATED, WHAT WAS THOUGHT TO BE 6473 04:26:30,165 --> 04:26:34,436 A DUALITY OF ESTROGEN AND 6474 04:26:34,436 --> 04:26:35,270 EFFECTS ON ATHEROSCLEROSIS. 6475 04:26:35,270 --> 04:26:40,009 WE KNEW EARLY ON THERE WAS MANY 6476 04:26:40,009 --> 04:26:47,683 BENEFICIAL EFFECTS OF ESTROGEN 6477 04:26:47,683 --> 04:26:48,617 ON ATHEROSCLEROSIS. 6478 04:26:48,617 --> 04:26:51,954 WITHIN SIX YEARS OF THE LAST 6479 04:26:51,954 --> 04:26:52,721 MENSTRUAL PERIOD, THERE'S 6480 04:26:52,721 --> 04:26:58,460 BEGINNING TO LOSE THE BENEFITS 6481 04:26:58,460 --> 04:26:59,294 FROM ESTROGEN. 6482 04:26:59,294 --> 04:27:03,599 THERE IS EVIDENCE THIS IS DUE TO 6483 04:27:03,599 --> 04:27:05,834 METHYLATION PROMOTER SITE OF THE 6484 04:27:05,834 --> 04:27:08,470 E.R. ALPHA GENE. 6485 04:27:08,470 --> 04:27:11,306 AND THEN LATER WHICH ACCOUNTED 6486 04:27:11,306 --> 04:27:16,045 FOR DUALITY WAS THIS POSSIBLE 6487 04:27:16,045 --> 04:27:16,812 ADVERSE EFFECT ON 6488 04:27:16,812 --> 04:27:19,314 ATHEROSCLEROSIS OR NULL EFFECT. 6489 04:27:19,314 --> 04:27:21,650 ALONG PATHOGENESIS OR AGING OF 6490 04:27:21,650 --> 04:27:24,253 VESSELS, THIS IS WHERE WE THEN 6491 04:27:24,253 --> 04:27:25,354 OVERLAY EFFECTS AND WHERE THE 6492 04:27:25,354 --> 04:27:27,523 DATA AS I'LL SHOW YOU IN A 6493 04:27:27,523 --> 04:27:30,059 MOMENT TEND TO THEN VALIDATE AND 6494 04:27:30,059 --> 04:27:32,661 WHERE THE TIMING HYPOTHESIS IS 6495 04:27:32,661 --> 04:27:37,399 DERIVED BASED ON MECHANISTIC 6496 04:27:37,399 --> 04:27:38,901 UNDERSTANDING OF THAT PROCESS. 6497 04:27:38,901 --> 04:27:43,839 EARLY ON WE CONDUCTED A SISTER 6498 04:27:43,839 --> 04:27:47,443 STUDY, LOOKING AT ESTRADIOL, 6499 04:27:47,443 --> 04:27:53,148 EARLY OR SUBCLINICAL 6500 04:27:53,148 --> 04:27:53,682 ATHEROSCLEROSIS, HEALTHY 6501 04:27:53,682 --> 04:27:54,349 ENDOTHELIUM, COMPLETELY HEALTHY 6502 04:27:54,349 --> 04:27:56,085 WOMEN, NO SYMPTOMS OF HEART 6503 04:27:56,085 --> 04:27:57,519 DISEASE, NO DIABETES, ET CETERA. 6504 04:27:57,519 --> 04:28:00,789 YOU CAN SEE THERE WAS A 6505 04:28:00,789 --> 04:28:01,790 SIGNIFICANT TREATMENT EFFECT, 6506 04:28:01,790 --> 04:28:06,061 VERSUS PLACEBO, IN THESE WOMEN. 6507 04:28:06,061 --> 04:28:08,197 WE LOOKED AT WOMEN WITH DISEASED 6508 04:28:08,197 --> 04:28:14,369 VESSELS, THIS IS A SERIAL TRIAL, 6509 04:28:14,369 --> 04:28:16,505 ESTABLISHED CORONARY DISEASE 6510 04:28:16,505 --> 04:28:18,640 WHEN ENTERING THE STUDY, 6511 04:28:18,640 --> 04:28:21,376 ESTRADIOL ALONE OR PLUS MPA 6512 04:28:21,376 --> 04:28:23,946 RELATIVE TO PLACEBO, NO 6513 04:28:23,946 --> 04:28:24,546 TREATMENT EFFECT. 6514 04:28:24,546 --> 04:28:28,150 THIS IS REALLY THE FIRST 6515 04:28:28,150 --> 04:28:30,753 EVIDENCE WE HAD CONSISTENT WITH 6516 04:28:30,753 --> 04:28:32,354 THE HEALTHY ENDOTHELIUM OR 6517 04:28:32,354 --> 04:28:34,590 TIMING HYPOTHESIS, IF YOU WILL, 6518 04:28:34,590 --> 04:28:36,992 WHICH DEMONSTRATES OR HOW WE 6519 04:28:36,992 --> 04:28:39,094 DEMONSTRATED HERE, IF YOU START 6520 04:28:39,094 --> 04:28:40,729 HORMONE THERAPY EARLY YOU 6521 04:28:40,729 --> 04:28:42,998 PREVENT OR SLOW DOWN THIS 6522 04:28:42,998 --> 04:28:45,534 VASCULAR AGING PROCESS, IF YOU 6523 04:28:45,534 --> 04:28:48,036 START IT LATE YOU CAN NO EFFECT 6524 04:28:48,036 --> 04:28:51,673 OR POTENTIALLY CAUSE PLAQUE 6525 04:28:51,673 --> 04:28:54,109 RUPTURE, WHICH THERE'S SOME 6526 04:28:54,109 --> 04:28:57,613 CLINICAL EVIDENCE FOR. 6527 04:28:57,613 --> 04:29:00,015 THIS IS NICELY DEMONSTRATED IN 6528 04:29:00,015 --> 04:29:01,750 THIS SPECIES OF ANIMAL. 6529 04:29:01,750 --> 04:29:04,286 THIS EFFECT IS SEEN IS MULTIPLE 6530 04:29:04,286 --> 04:29:04,520 SPECIES. 6531 04:29:04,520 --> 04:29:06,155 THIS IS MICE, NON-HUMAN PRIMATE, 6532 04:29:06,155 --> 04:29:10,058 IT'S BEEN SEEN IN RATS, AND 6533 04:29:10,058 --> 04:29:14,663 BASICALLY IF YOU START HORMONE 6534 04:29:14,663 --> 04:29:17,633 THERAPY, ESTRADIOL IN THIS CASE, 6535 04:29:17,633 --> 04:29:18,734 CREATE ATHEROSCLEROSIS VIA 6536 04:29:18,734 --> 04:29:20,702 CHOLESTEROL FEEDING AND OTHER 6537 04:29:20,702 --> 04:29:23,005 PROCESSES, YOU CAN PREVENT NEW 6538 04:29:23,005 --> 04:29:25,774 LESION FORMATION. 6539 04:29:25,774 --> 04:29:30,612 WITH ESTROGEN. 6540 04:29:30,612 --> 04:29:35,484 HOWEVER, IN -- OOPS. 6541 04:29:35,484 --> 04:29:37,452 HOWEVER, IN ANIMALS THAT DID NOT 6542 04:29:37,452 --> 04:29:38,587 RECEIVE -- SORRY, I DON'T KNOW 6543 04:29:38,587 --> 04:29:40,122 WHY IT'S NOT WORKING. 6544 04:29:40,122 --> 04:29:42,791 DID NOT RECEIVE HORMONE THERAPY, 6545 04:29:42,791 --> 04:29:44,493 THEY PROGRESSED WITH NEW 6546 04:29:44,493 --> 04:29:45,694 LESIONS. 6547 04:29:45,694 --> 04:29:47,563 FAR GRAPH YOU CAN SEE WHEN THEY 6548 04:29:47,563 --> 04:29:49,965 DID RECEIVE ESTROGEN OR PLACEBO, 6549 04:29:49,965 --> 04:29:52,034 IT DIDN'T MATTER, ONCE THE 6550 04:29:52,034 --> 04:29:52,835 LESIONS WERE ESTABLISHED THERE 6551 04:29:52,835 --> 04:29:55,337 WAS NO TREATMENT EFFECT. 6552 04:29:55,337 --> 04:29:58,273 SO AGAIN IT APPEARS AT LEAST 6553 04:29:58,273 --> 04:30:01,276 WITH ANIMALS, PRETTY CONSISTENT 6554 04:30:01,276 --> 04:30:04,546 EFFECT THAT YOU CAN PREVENT NEW 6555 04:30:04,546 --> 04:30:05,948 LESION FORMATION BEFORE 6556 04:30:05,948 --> 04:30:07,182 ATHEROSCLEROSIS DEVELOPS BUT YOU 6557 04:30:07,182 --> 04:30:15,157 CAN'T REVERSE IT OR INHIBIT IT 6558 04:30:15,157 --> 04:30:16,558 ONCE IT'S ESTABLISHED. 6559 04:30:16,558 --> 04:30:18,861 MAYBE THE BATTERY IS DYING. 6560 04:30:18,861 --> 04:30:22,431 I'M GOING TO SKIP FORWARD TO 6561 04:30:22,431 --> 04:30:32,908 WHERE WE ARE -- I CAN'T - - 6562 04:30:34,810 --> 04:30:36,612 DOESN'T SEEM TO BE RESPONDING. 6563 04:30:36,612 --> 04:30:39,047 NEXT SLIDE. 6564 04:30:39,047 --> 04:30:41,950 TO STUDY TIMING HYPOTHESIS WE 6565 04:30:41,950 --> 04:30:44,519 COMPLETED THIS STUDY PUBLISHED 6566 04:30:44,519 --> 04:30:46,154 IN NEW ENGLAND JOURNAL, 2015. 6567 04:30:46,154 --> 04:30:52,961 IT STILL REMAINS THE ONLY DIRECT 6568 04:30:52,961 --> 04:31:03,639 TEST OF TIMING HYPOTHESIS, 643 6569 04:31:03,639 --> 04:31:07,743 HEALTHY WOMEN, RANDOMIZED ORAL 6570 04:31:07,743 --> 04:31:09,378 17 BETA VERSUS PLACEBO, 6571 04:31:09,378 --> 04:31:11,246 STRATIFIED BASED ON TIME SINCE 6572 04:31:11,246 --> 04:31:11,947 MENOPAUSE. 6573 04:31:11,947 --> 04:31:15,751 SO WOMEN CLOSE TO MENOPAUSE, 6574 04:31:15,751 --> 04:31:24,826 WITHIN SIX YEARS, AND 10 OR MORE 6575 04:31:24,826 --> 04:31:25,827 YEARS BEYOND MENOPAUSE. 6576 04:31:25,827 --> 04:31:30,198 YOU'LL HAVE TO ADVANCE IT. 6577 04:31:30,198 --> 04:31:33,368 THAT'S GOOD. 6578 04:31:33,368 --> 04:31:36,305 YOU CAN SEE VERY CLEAR 6579 04:31:36,305 --> 04:31:37,306 DISTINCTION BETWEEN WOMEN CLOSE 6580 04:31:37,306 --> 04:31:39,374 TO MENOPAUSE WITHIN 3 1/2 YEARS 6581 04:31:39,374 --> 04:31:42,878 AND EARLY GROUP, AND LATE GROUP 6582 04:31:42,878 --> 04:31:46,048 OF WOMEN ABOUT 14 1/2 YEARS PAST 6583 04:31:46,048 --> 04:31:48,884 MENOPAUSE, AGE IS GREATER IN 6584 04:31:48,884 --> 04:31:53,488 WOMEN MORE THAN TEN YEARS. 6585 04:31:53,488 --> 04:31:54,056 NEXT SLIDE. 6586 04:31:54,056 --> 04:31:56,224 BOTTOM PORTION OF THE GRAPH, 6587 04:31:56,224 --> 04:31:57,526 THESE ARE THE WOMEN RANDOMIZED 6588 04:31:57,526 --> 04:31:59,161 WITHIN SIX YEARS OF MENOPAUSE, 6589 04:31:59,161 --> 04:32:01,029 ABOUT YEAR AND A HALF TO TWO 6590 04:32:01,029 --> 04:32:03,131 YEARS THERE WAS A SIGNIFICANT 6591 04:32:03,131 --> 04:32:05,634 TREATMENT EFFECT IN THIS GROUP 6592 04:32:05,634 --> 04:32:08,637 OF WOMEN, ESTROGEN VERSUS 6593 04:32:08,637 --> 04:32:11,239 PLACEBO, UPPER TWO LINES YOU CAN 6594 04:32:11,239 --> 04:32:12,240 SEE NO TREATMENT EFFECT, THESE 6595 04:32:12,240 --> 04:32:19,448 ARE MORE THAN TEN YEARS FROM 6596 04:32:19,448 --> 04:32:20,215 MENOPAUSE. 6597 04:32:20,215 --> 04:32:21,750 DIRECT EVIDENCE FOR TIMING 6598 04:32:21,750 --> 04:32:25,454 HYPOTHESIS, EARLY TREATMENT OR 6599 04:32:25,454 --> 04:32:26,888 REDUCTION OF ATHEROSCLEROSIS, 6600 04:32:26,888 --> 04:32:29,624 LATE INTERVENTION TEN YEARS OR 6601 04:32:29,624 --> 04:32:32,928 MORE NO EFFECT. 6602 04:32:32,928 --> 04:32:33,562 NEXT SLIDE. 6603 04:32:33,562 --> 04:32:35,664 SO NOW THIS IS ATHEROSCLEROSIS. 6604 04:32:35,664 --> 04:32:38,400 WE KNOW ATHEROSCLEROSIS IS THE 6605 04:32:38,400 --> 04:32:39,334 MAJOR UNDERLYING CAUSE OF 6606 04:32:39,334 --> 04:32:40,035 CARDIOVASCULAR DISEASE. 6607 04:32:40,035 --> 04:32:41,470 THE QUESTION IS HOW DOES THIS 6608 04:32:41,470 --> 04:32:44,639 LOOK IN TERMS OF CORONARY HEART 6609 04:32:44,639 --> 04:32:45,507 DISEASE OUTCOMES? 6610 04:32:45,507 --> 04:32:49,878 THIS WAS THE FIRST META-ANALYSIS 6611 04:32:49,878 --> 04:32:51,413 CONDUCTED, STANFORD. 6612 04:32:51,413 --> 04:32:53,048 BOX INDICATES WOMEN WHO ARE 6613 04:32:53,048 --> 04:32:54,950 CLOSE TO MENOPAUSE, WITHIN SIX 6614 04:32:54,950 --> 04:32:58,453 YEARS OR LESS THAN 60 YEARS OLD. 6615 04:32:58,453 --> 04:33:01,723 YOU CAN SEE A SIGNIFICANT EFFECT 6616 04:33:01,723 --> 04:33:03,725 IN META-ANALYSIS, A FEW DOZEN 6617 04:33:03,725 --> 04:33:05,894 STUDIES, REDUCTION OF HEART 6618 04:33:05,894 --> 04:33:08,096 DISEASE, WOMEN RANDOMIZED TO 6619 04:33:08,096 --> 04:33:11,266 HORMONE THERAPY VERSUS PLACEBO. 6620 04:33:11,266 --> 04:33:13,235 AND THE COMPANION SLIDE, YOU CAN 6621 04:33:13,235 --> 04:33:15,871 SEE THAT THERE'S ALSO A 6622 04:33:15,871 --> 04:33:18,273 SIGNIFICANT REDUCTION IN 6623 04:33:18,273 --> 04:33:19,241 ALL-CAUSE MORTALITY, NULL 6624 04:33:19,241 --> 04:33:21,710 EFFECTS IN WOMEN MORE THAN TEN 6625 04:33:21,710 --> 04:33:24,513 YEARS OR OLDER, MORE THAN TEN 6626 04:33:24,513 --> 04:33:25,614 YEARS SINCE MENOPAUSE, OLDER 6627 04:33:25,614 --> 04:33:28,450 THAN 60 YEARS OF AGE. 6628 04:33:28,450 --> 04:33:30,419 NEXT SLIDE. 6629 04:33:30,419 --> 04:33:32,487 THESE WERE CONFIRMED BY COCHRANE 6630 04:33:32,487 --> 04:33:33,688 META-ANALYSIS, SAME EFFECT. 6631 04:33:33,688 --> 04:33:35,891 SIGNIFICANT REDUCTION IN HEART 6632 04:33:35,891 --> 04:33:42,998 DISEASE, ALL-CAUSE MORTALITY, IN 6633 04:33:42,998 --> 04:33:44,099 WOMEN RANDOMIZED TO HORMONE 6634 04:33:44,099 --> 04:33:46,068 THERAPY, NO EFFECT IN THOSE 6635 04:33:46,068 --> 04:33:50,338 RANDOMIZED GREATER THAN TEN 6636 04:33:50,338 --> 04:33:53,075 YEARS OR GREATER THAN 60 YEARS 6637 04:33:53,075 --> 04:33:53,742 OLD. 6638 04:33:53,742 --> 04:33:54,943 NEXT SLIDE. 6639 04:33:54,943 --> 04:33:57,345 NOW, THE CLOSEST STUDY THAT'S 6640 04:33:57,345 --> 04:33:59,448 BEEN CONDUCTED IS A DANISH 6641 04:33:59,448 --> 04:34:02,084 OSTEOPOROSIS STUDY WHERE THEY 6642 04:34:02,084 --> 04:34:05,353 LOOKED AT CARDIOVASCULAR DISEASE 6643 04:34:05,353 --> 04:34:05,887 OUTCOME. 6644 04:34:05,887 --> 04:34:07,656 THESE WOMEN WERE WITHIN -- THIS 6645 04:34:07,656 --> 04:34:09,858 IS AVERAGE TIME, SEVEN MONTHS 6646 04:34:09,858 --> 04:34:11,059 FROM MENOPAUSE, AVERAGE AGE 50 6647 04:34:11,059 --> 04:34:12,794 YEARS. 6648 04:34:12,794 --> 04:34:14,996 THIS IS THE CLOSEST RANDOMIZED 6649 04:34:14,996 --> 04:34:17,933 TRIAL OF WOMEN THAT WE HAVE TO 6650 04:34:17,933 --> 04:34:20,469 EMULATE OR REALLY TEST THE 6651 04:34:20,469 --> 04:34:22,637 OBSERVATIONAL STUDIES. 6652 04:34:22,637 --> 04:34:26,174 AND YOU CAN SEE UP TO TEN YEARS, 6653 04:34:26,174 --> 04:34:28,343 THE LINE DELINEATES TEN-YEAR 6654 04:34:28,343 --> 04:34:30,745 POINT, WOMEN ON HORMONE THERAPY 6655 04:34:30,745 --> 04:34:31,813 VERSUS CONTROL GROUP. 6656 04:34:31,813 --> 04:34:34,883 AND YOU CAN SEE SIGNIFICANT 6657 04:34:34,883 --> 04:34:36,318 REDUCTION IN THIS KAPLAN-MEIER 6658 04:34:36,318 --> 04:34:39,621 CURVE, IN THE NUMBER OF EVENTS 6659 04:34:39,621 --> 04:34:42,791 VERSUS CONTROL GROUP. 6660 04:34:42,791 --> 04:34:45,427 AND THEN AS THE WOMEN EXITED 6661 04:34:45,427 --> 04:34:47,162 THEY WERE FOLLOWED AND 16 YEARS 6662 04:34:47,162 --> 04:34:52,501 LATER THAT TREATMENT EFFECT WAS 6663 04:34:52,501 --> 04:34:55,570 STILL EVIDENT. 6664 04:34:55,570 --> 04:34:56,705 NEXT SLIDE. 6665 04:34:56,705 --> 04:34:58,006 GO BACK. 6666 04:34:58,006 --> 04:35:00,041 THAT'S IT, YEAH, SORRY. 6667 04:35:00,041 --> 04:35:00,208 YEP. 6668 04:35:00,208 --> 04:35:06,314 SO WHEN YOU TAKE A LOOK AT THESE 6669 04:35:06,314 --> 04:35:16,291 STUDIES WHERE WOMEN WERE -- 6670 04:35:16,291 --> 04:35:17,592 STUDIES ANALYZED, INCLUDING 6671 04:35:17,592 --> 04:35:19,361 COCHRANE AND STANFORD, THE ELITE 6672 04:35:19,361 --> 04:35:22,731 STUDY THAT I SHOWED YOU IN 6673 04:35:22,731 --> 04:35:24,733 IMAGING, ALL REALLY DO COMPORT 6674 04:35:24,733 --> 04:35:27,002 OR ARE CONSISTENT WITH THE 6675 04:35:27,002 --> 04:35:28,537 OBSERVATIONAL STUDIES SHOWING 6676 04:35:28,537 --> 04:35:30,505 REDUCTION IN CORONARY HEART 6677 04:35:30,505 --> 04:35:31,506 DISEASE. 6678 04:35:31,506 --> 04:35:34,776 AGAIN, TRUE FOR ALL-CAUSE 6679 04:35:34,776 --> 04:35:35,277 MORTALITY. 6680 04:35:35,277 --> 04:35:37,412 NEXT SLIDE. 6681 04:35:37,412 --> 04:35:40,248 NEXT SLIDE AGAIN. 6682 04:35:40,248 --> 04:35:42,117 MORE ABOUT MORTALITY, WHI STUDY, 6683 04:35:42,117 --> 04:35:49,257 SUBGROUP OF WOMEN LESS THAN 60 6684 04:35:49,257 --> 04:35:51,193 AND RANDOMIZED, MORTALITY IN THE 6685 04:35:51,193 --> 04:35:52,594 NEXT GROUP, CANCER MORTALITY, 6686 04:35:52,594 --> 04:35:54,262 AND OTHER MORTALITY. 6687 04:35:54,262 --> 04:35:56,998 YOU CAN SEE THAT NOT ONLY IS 6688 04:35:56,998 --> 04:35:59,401 ALL-CAUSE MORTALITY REDUCED BUT 6689 04:35:59,401 --> 04:36:04,539 SO ARE THE SPECIFIED MORTALITIES 6690 04:36:04,539 --> 04:36:04,739 ALSO. 6691 04:36:04,739 --> 04:36:06,508 NEXT SLIDE. 6692 04:36:06,508 --> 04:36:07,809 THIS COMES FROM 18-YEAR 6693 04:36:07,809 --> 04:36:11,112 CUMULATIVE FOLLOW-UP. 6694 04:36:11,112 --> 04:36:12,080 THERE'S EVEN REDUCTION IN 6695 04:36:12,080 --> 04:36:16,785 ALZHEIMER'S DISEASE OR DEMENTIA 6696 04:36:16,785 --> 04:36:17,986 MORTALITY. 6697 04:36:17,986 --> 04:36:19,521 NEXT SLIDE. 6698 04:36:19,521 --> 04:36:20,822 SO, WHAT'S REALLY IMPORTANT 6699 04:36:20,822 --> 04:36:23,925 ABOUT WOMEN AND YOU WANT TO TALK 6700 04:36:23,925 --> 04:36:25,760 ABOUT A SEX DIFFERENTIATOR FROM 6701 04:36:25,760 --> 04:36:26,561 MEN IS DIABETES. 6702 04:36:26,561 --> 04:36:28,830 THIS IS REALLY ONE OF THE ONLY 6703 04:36:28,830 --> 04:36:31,233 RISK FACTORS THAT ERASES THE 6704 04:36:31,233 --> 04:36:33,001 PRE-MENOPAUSAL PROTECTION WOMEN 6705 04:36:33,001 --> 04:36:36,171 HAVE FROM HEART DISEASE. 6706 04:36:36,171 --> 04:36:36,538 THAT'S DIABETES. 6707 04:36:36,538 --> 04:36:38,473 50 YEARS AGO FRAMINGHAM SHOWED 6708 04:36:38,473 --> 04:36:42,210 US THAT WOMEN ARE ALSO AT 6709 04:36:42,210 --> 04:36:43,511 GREATER RISK FOR HEART DISEASE 6710 04:36:43,511 --> 04:36:46,781 THAN ARE MEN WHEN THEY HAVE 6711 04:36:46,781 --> 04:36:51,486 DIABETES, YOU SEE IN THE FAR 6712 04:36:51,486 --> 04:36:55,190 PART OF THE GRAPH A RISK RATIO 6713 04:36:55,190 --> 04:37:00,795 OF ABOUT 5:1 OF DIABETES TO 6714 04:37:00,795 --> 04:37:03,665 NON-DIABETIC DIABETES -- 6715 04:37:03,665 --> 04:37:05,834 DIABETIC WOMEN, AND OVER ON THE 6716 04:37:05,834 --> 04:37:07,602 CLOSER PART OF THE GRAPH, LEFT 6717 04:37:07,602 --> 04:37:10,605 PART, IN MEN THAT'S ABOUT HALF, 6718 04:37:10,605 --> 04:37:12,207 2 1/2-FOLD RISK FOR CORONARY 6719 04:37:12,207 --> 04:37:15,710 HEART DISEASE IN MEN WHO HAVE 6720 04:37:15,710 --> 04:37:17,212 DIABETES VERSUS NO DIABETES. 6721 04:37:17,212 --> 04:37:19,281 NEXT SLIDE. 6722 04:37:19,281 --> 04:37:20,615 THAT'S IMPORTANT BECAUSE WE'VE 6723 04:37:20,615 --> 04:37:23,885 KNOWN FOR QUITE A WHILE, AGAIN 6724 04:37:23,885 --> 04:37:26,621 THIS IS YOUR LEFT LOWER QUADRANT 6725 04:37:26,621 --> 04:37:28,256 THERE'S A CONSISTENT EFFECT OF 6726 04:37:28,256 --> 04:37:31,326 HORMONE THERAPY ON NEW ONSET 6727 04:37:31,326 --> 04:37:34,296 DIABETES, WHETHER YOU LOOK AT 6728 04:37:34,296 --> 04:37:38,133 LARGE META-ANALYSIS OF OVER 100 6729 04:37:38,133 --> 04:37:41,069 RANDOMIZED TRIALS, INDIVIDUAL 6730 04:37:41,069 --> 04:37:47,108 STUDIES, I'M JUST SHOWING WHI 6731 04:37:47,108 --> 04:37:51,479 HRT, CONSISTENT REDUCTION IN NEW 6732 04:37:51,479 --> 04:37:52,347 ONSET, DIFFERENTIATING FROM 6733 04:37:52,347 --> 04:37:54,949 STATIN USE IN WOMEN, INCREASED 6734 04:37:54,949 --> 04:37:55,817 NEW ONSET DIABETES. 6735 04:37:55,817 --> 04:37:59,654 IT'S THESE DATA THAT LED TO THE 6736 04:37:59,654 --> 04:38:02,691 ADDED LABELING OF STATIN THERAPY 6737 04:38:02,691 --> 04:38:06,761 IN APRIL OF 2012, OF THE WARNING 6738 04:38:06,761 --> 04:38:08,496 OF NEW ONSET DIABETES WITH USE 6739 04:38:08,496 --> 04:38:11,266 OF STATINS. 6740 04:38:11,266 --> 04:38:14,336 THAT RISK IS 10 PER 10,000, MORE 6741 04:38:14,336 --> 04:38:17,138 THAN A RARE RISK. 6742 04:38:17,138 --> 04:38:18,039 NEXT SLIDE. 6743 04:38:18,039 --> 04:38:20,809 SO THIS IS WHI DATA ALSO IN 6744 04:38:20,809 --> 04:38:23,278 WOMEN LESS THAN 60 YEARS OF AGE. 6745 04:38:23,278 --> 04:38:25,146 DATA IS GREAT BECAUSE WE CAN 6746 04:38:25,146 --> 04:38:27,315 LOOK AT ABSOLUTE RISK. 6747 04:38:27,315 --> 04:38:30,618 WHAT REALLY STANDS OUT IN ALL 6748 04:38:30,618 --> 04:38:33,121 THE OUTCOMES ANALYZED IN WHI 6749 04:38:33,121 --> 04:38:34,556 PRETTY MUCH DISPLAYED HERE IS 6750 04:38:34,556 --> 04:38:38,259 THAT THE ONE RISK FACTOR, ONE 6751 04:38:38,259 --> 04:38:48,536 RISK OPT OUT WAS THE CE PLUS MPA 6752 04:38:48,536 --> 04:38:50,405 TRIAL, SIGNIFICANT EFFECT ON 6753 04:38:50,405 --> 04:38:53,007 DEEP VAIN THROMBOSIS, ALL OTHERS 6754 04:38:53,007 --> 04:38:54,476 WERE INSIGNIFICANT. 6755 04:38:54,476 --> 04:38:57,412 YOU CAN SEE BY RED CIRCLE AND 6756 04:38:57,412 --> 04:39:02,650 ARROW BELOW THE RARE LEVEL OF 6757 04:39:02,650 --> 04:39:03,318 RISK. 6758 04:39:03,318 --> 04:39:04,386 NEXT SLIDE. 6759 04:39:04,386 --> 04:39:05,086 IN CONCLUSION, CARDIOVASCULAR 6760 04:39:05,086 --> 04:39:09,124 DISEASE IS THE NUMBER ONE CAUSE 6761 04:39:09,124 --> 04:39:11,092 OF DEATH IN WOMEN, POST 6762 04:39:11,092 --> 04:39:12,827 MENOPAUSAL INCREASED WOMEN ARE 6763 04:39:12,827 --> 04:39:13,628 AT INCREASED RISK FOR 6764 04:39:13,628 --> 04:39:14,429 CARDIOVASCULAR DISEASE. 6765 04:39:14,429 --> 04:39:15,997 WHETHER THAT'S DUE TO THE LOSS 6766 04:39:15,997 --> 04:39:18,433 OF ESTROGEN OR NOT IS AN AREA 6767 04:39:18,433 --> 04:39:22,337 THAT IS UNDER ACTIVE 6768 04:39:22,337 --> 04:39:22,670 INVESTIGATION. 6769 04:39:22,670 --> 04:39:26,307 SO MENOPAUSAL HORMONE THERAPY IS 6770 04:39:26,307 --> 04:39:27,609 COST EFFECTIVE, IT'S 6771 04:39:27,609 --> 04:39:29,244 SEX-SPECIFIC THERAPY, APPEARS TO 6772 04:39:29,244 --> 04:39:33,281 REDUCE ALL-CAUSE MORTALITY AND 6773 04:39:33,281 --> 04:39:34,616 SPECIFIC MORTALITIES, REDUCES 6774 04:39:34,616 --> 04:39:38,219 HEART DISEASE, BONE FRACTURE 6775 04:39:38,219 --> 04:39:39,187 REDUCED IN NON-SELECTED 6776 04:39:39,187 --> 04:39:43,458 POPULATION, MOST STUDIES DONE IN 6777 04:39:43,458 --> 04:39:44,426 HIGH-RISK FRACTURE RISK 6778 04:39:44,426 --> 04:39:48,596 PATIENTS, AND REDUCES NEW ONSET 6779 04:39:48,596 --> 04:39:49,097 DIABETES. 6780 04:39:49,097 --> 04:39:51,132 BENEFITS OF MENOPAUSAL HORMONE 6781 04:39:51,132 --> 04:39:52,434 THERAPY CLEARLY OUTWEIGH THE 6782 04:39:52,434 --> 04:39:54,302 RISK WHEN INITIATED AROUND THE 6783 04:39:54,302 --> 04:39:56,704 TIME OF MENOPAUSE. 6784 04:39:56,704 --> 04:39:59,874 NOW, THERE'S MANY, MANY 6785 04:39:59,874 --> 04:40:00,975 UNANSWERED QUESTIONS. 6786 04:40:00,975 --> 04:40:05,113 ONE OF THE ISSUES, I DIDN'T HAVE 6787 04:40:05,113 --> 04:40:14,756 TIME TO GO INTO, THERE'S 6788 04:40:14,756 --> 04:40:15,957 THEORIES IT'S PROGESTERONE 6789 04:40:15,957 --> 04:40:19,360 AGENT, NOT PROVEN BUT THEORIZED. 6790 04:40:19,360 --> 04:40:21,429 THERE'S NEW CLASSES OF DRUGS, 6791 04:40:21,429 --> 04:40:24,599 TSEC IS ONE OF THEM, AND NIA 6792 04:40:24,599 --> 04:40:27,335 FUNDED US TO LOOK AT THIS 6793 04:40:27,335 --> 04:40:29,337 BECAUSE WE CAN DELIVER ESTROGEN 6794 04:40:29,337 --> 04:40:31,172 WITHOUT THE RISK, IF THERE IS 6795 04:40:31,172 --> 04:40:38,112 ANY, OF PROGESTERINAL AGENT TO 6796 04:40:38,112 --> 04:40:48,456 PROTECT THE UTERUS, TO COMPLETE 6797 04:40:48,456 --> 04:40:51,726 IN THE NEXT YEAR OR TWO. 6798 04:40:51,726 --> 04:40:54,262 CONJUGATED ESTROGEN, AS YOU MAY 6799 04:40:54,262 --> 04:40:56,231 KNOW, IN WHI THERE WAS 6800 04:40:56,231 --> 04:40:57,131 STATISTICALLY SIGNIFICANT 6801 04:40:57,131 --> 04:41:01,035 REDUCTION OF BREAST CANCER WITH 6802 04:41:01,035 --> 04:41:01,970 CONJUGATED ESTROGEN, AND 6803 04:41:01,970 --> 04:41:04,873 ESTROGEN-ONLY STUDY, THIS IS A 6804 04:41:04,873 --> 04:41:09,043 GOOD CANDIDATE DRUG, WHAT 6805 04:41:09,043 --> 04:41:12,213 PROTECTS THE UTERUS IS A 6806 04:41:12,213 --> 04:41:13,615 SELECTIVE ESTROGEN RECEPTOR 6807 04:41:13,615 --> 04:41:17,552 MODULATOR, MORE COMMONLY CALLED 6808 04:41:17,552 --> 04:41:24,559 ESTROGEN AGONIST ANTAGONIST. 6809 04:41:24,559 --> 04:41:29,697 CONJUGATED ESTROGENS ARE REALLY 6810 04:41:29,697 --> 04:41:31,366 SERMS. 6811 04:41:31,366 --> 04:41:32,867 THE OTHER IMPORTANT AREA THAT 6812 04:41:32,867 --> 04:41:40,575 WE'RE PURSUING NOW IS TO 6813 04:41:40,575 --> 04:41:43,678 UNDERSTAND VASCULAR RESPONSE IN 6814 04:41:43,678 --> 04:41:50,485 THE BRAIN IN RELATION TO ADRD. 6815 04:41:50,485 --> 04:41:53,655 THIS ARTICLE SUMS THIS UP. 6816 04:41:53,655 --> 04:41:56,057 IT ALSO SPELLS OUT SOME OF THE 6817 04:41:56,057 --> 04:41:58,259 OTHER SEX DIFFERENCES THAT I 6818 04:41:58,259 --> 04:42:01,729 WASN'T REALLY ABLE TO COVER IN 6819 04:42:01,729 --> 04:42:02,730 ONLY 15 MINUTES. 6820 04:42:02,730 --> 04:42:08,636 I GUESS I HAD TEN MINUTES. 6821 04:42:08,636 --> 04:42:09,837 THANKS. 6822 04:42:09,837 --> 04:42:11,472 MY PARTNER SAYS I NEVER TALK. 6823 04:42:11,472 --> 04:42:12,173 I GRUNT. 6824 04:42:12,173 --> 04:42:14,776 I THINK THAT'S A MAN THING. 6825 04:42:14,776 --> 04:42:20,014 THE ONLY TIME I COME ALIVE AND 6826 04:42:20,014 --> 04:42:21,115 AM ANIMATED, TALK, TALK, TALK, 6827 04:42:21,115 --> 04:42:22,750 IS WHEN I TALK ABOUT MENOPAUSE 6828 04:42:22,750 --> 04:42:23,418 AND WOMEN'S HEALTH. 6829 04:42:23,418 --> 04:42:24,085 THANK YOU ALL. 6830 04:42:24,085 --> 04:42:26,588 APPRECIATE IT. 6831 04:42:26,588 --> 04:42:32,594 6832 04:42:32,594 --> 04:42:33,828 6833 04:42:33,828 --> 04:42:38,499 >> THANK YOU FOR THREE EXCELLENT 6834 04:42:38,499 --> 04:42:38,700 TALKS. 6835 04:42:38,700 --> 04:42:42,503 ARE THERE ANY QUESTIONS AROUND 6836 04:42:42,503 --> 04:42:52,914 THE TABLE FOR SPEAKERS? 6837 04:43:01,990 --> 04:43:04,559 AS WE LEARN ABOUT ATTITUDES AND 6838 04:43:04,559 --> 04:43:06,294 EXPERIENCES OF MENOPAUSE ACROSS 6839 04:43:06,294 --> 04:43:09,497 DIFFERENT ETHNIC AND RACIAL 6840 04:43:09,497 --> 04:43:16,371 GROUPS, IMPACT OF MENOPAUSAL 6841 04:43:16,371 --> 04:43:18,673 LATER OUTCOMES, WHAT IS MONEY 6842 04:43:18,673 --> 04:43:22,310 ABOUT HORMONE THERAPY IN, FOR 6843 04:43:22,310 --> 04:43:24,145 EXAMPLE, BLACK WOMEN OR ACROSS 6844 04:43:24,145 --> 04:43:25,780 RACE/ETHNICITY GROUPS WITH 6845 04:43:25,780 --> 04:43:27,215 RESPECT TO TIMING HYPOTHESIS AND 6846 04:43:27,215 --> 04:43:29,183 PREVENTION OF CHRONIC CONDITIONS 6847 04:43:29,183 --> 04:43:30,852 IN LATER LIFE? 6848 04:43:30,852 --> 04:43:37,625 >> THAT'S A GREAT QUESTION. 6849 04:43:37,625 --> 04:43:40,928 AND WE STRUGGLE HARD TO MAKE 6850 04:43:40,928 --> 04:43:44,298 SURE THAT OUR TRIALS WERE WELL 6851 04:43:44,298 --> 04:43:46,801 REPRESENTED, AND WITH THAT SAID, 6852 04:43:46,801 --> 04:43:49,871 THERE'S SMALL CUP GROUPS BUT WE 6853 04:43:49,871 --> 04:43:50,638 DIDN'T REALLY SEE MUCH 6854 04:43:50,638 --> 04:43:52,407 DIFFERENCE IN TERMS OF THE 6855 04:43:52,407 --> 04:43:53,608 CARDIOVASCULAR BUT WE KNOW 6856 04:43:53,608 --> 04:43:54,676 THAT'S PROBABLY NOT TRUE. 6857 04:43:54,676 --> 04:43:57,211 I JUST SAW A GREAT LECTURE 6858 04:43:57,211 --> 04:43:58,079 TALKING ABOUT BONE DIFFERENCES, 6859 04:43:58,079 --> 04:43:59,847 AND WE KNOW THAT EXISTS. 6860 04:43:59,847 --> 04:44:01,582 SO IT'S HARD TO -- BIOLOGY IS 6861 04:44:01,582 --> 04:44:02,050 BIOLOGY. 6862 04:44:02,050 --> 04:44:03,785 IT'S HARD TO BELIEVE WE'D BE 6863 04:44:03,785 --> 04:44:04,986 DIFFERENT IN THE CARDIOVASCULAR 6864 04:44:04,986 --> 04:44:05,420 SYSTEM. 6865 04:44:05,420 --> 04:44:07,955 WE NEED MUCH LARGER STUDIES TO 6866 04:44:07,955 --> 04:44:11,092 UNDERSTAND THAT. 6867 04:44:11,092 --> 04:44:13,528 >> SO A FOLLOW-UP QUESTION FOR 6868 04:44:13,528 --> 04:44:14,295 DR. BRINTON. 6869 04:44:14,295 --> 04:44:16,464 SO, RELATED TO THE DATA 6870 04:44:16,464 --> 04:44:18,166 PRESENTED BY DR. HODIS WHAT ARE 6871 04:44:18,166 --> 04:44:19,967 YOUR THOUGHTS REGARDING THE 6872 04:44:19,967 --> 04:44:21,502 TIMING AND DURATION OF 6873 04:44:21,502 --> 04:44:24,138 MENOPAUSAL HORMONE THERAPY THAT 6874 04:44:24,138 --> 04:44:26,541 MIGHT BE NEEDED TO PROMOTE 6875 04:44:26,541 --> 04:44:29,610 COGNITIVE HEALTH? 6876 04:44:29,610 --> 04:44:32,880 >> I THINK WHAT IS REALLY 6877 04:44:32,880 --> 04:44:35,983 IMPRESSIVE IS THE 6878 04:44:35,983 --> 04:44:37,685 REPRODUCIBILITY ACROSS DIFFERENT 6879 04:44:37,685 --> 04:44:40,788 SYSTEMS, CARDIAC SYSTEM, THE 6880 04:44:40,788 --> 04:44:44,525 BRAIN, THAT INTERVENTION AS YOU 6881 04:44:44,525 --> 04:44:48,329 MIGHT RECALL, THE SYSTEMS OF 6882 04:44:48,329 --> 04:44:49,864 BIOLOGY ARE CHANGING DURING THIS 6883 04:44:49,864 --> 04:44:53,067 COURSE OF THIS TRANSITION STATE. 6884 04:44:53,067 --> 04:44:56,571 AND THAT INTERVENTION AT ONE 6885 04:44:56,571 --> 04:45:00,174 POINT EARLY ON WHEN SYMPTOMS 6886 04:45:00,174 --> 04:45:03,444 FIRST APPEAR CAN CHANGE THE 6887 04:45:03,444 --> 04:45:04,979 TRAJECTORY OF AGING. 6888 04:45:04,979 --> 04:45:06,614 FROM A VULNERABLE AGING PROFILE, 6889 04:45:06,614 --> 04:45:10,351 WHETHER THAT'S FROM A 6890 04:45:10,351 --> 04:45:12,653 NEUROLOGICAL PERSPECTIVE, OR A 6891 04:45:12,653 --> 04:45:16,157 CARDIOVASCULAR PERSPECTIVE, OR 6892 04:45:16,157 --> 04:45:17,658 AN IMMUNE PERSPECTIVE. 6893 04:45:17,658 --> 04:45:20,728 AND KIND OF AN AUTOIMMUNE 6894 04:45:20,728 --> 04:45:24,031 DISEASE PERSPECTIVE. 6895 04:45:24,031 --> 04:45:26,334 I'VE BEEN QUITE IMPRESSED 6896 04:45:26,334 --> 04:45:28,970 STUDYING THE IMMUNE SYSTEM WAS 6897 04:45:28,970 --> 04:45:30,738 SOMETHING THAT I FOUGHT TOOTH 6898 04:45:30,738 --> 04:45:33,741 AND NAIL UNTIL THE BRAIN TOLD ME 6899 04:45:33,741 --> 04:45:40,148 YOU MUST. 6900 04:45:40,148 --> 04:45:41,682 AND SO WE DID. 6901 04:45:41,682 --> 04:45:44,418 THIS IS ANOTHER SHARED COMMON 6902 04:45:44,418 --> 04:45:45,920 DRIVER ACROSS THESE SYSTEMS OF 6903 04:45:45,920 --> 04:45:47,255 BIOLOGY, AND IT WILL BE 6904 04:45:47,255 --> 04:45:48,456 INTERESTING TO KNOW WHETHER THIS 6905 04:45:48,456 --> 04:45:52,160 IS TRUE IN BONE AS WELL, IS 6906 04:45:52,160 --> 04:45:56,898 ACTIVATION OF THE IMMUNE SYSTEM. 6907 04:45:56,898 --> 04:46:02,136 AND WE TYPICALLY GROUP THAT 6908 04:46:02,136 --> 04:46:02,904 AROUND INFLAMMATION, BUT OUR 6909 04:46:02,904 --> 04:46:05,873 RESEARCH AS WELL AS OTHERS HAVE 6910 04:46:05,873 --> 04:46:08,276 DIFFERENTIATED BETWEEN THERE'S 6911 04:46:08,276 --> 04:46:09,911 THIS EARLY ACTIVATION OF A 6912 04:46:09,911 --> 04:46:13,481 WARNING SIGNAL, THE INNATE 6913 04:46:13,481 --> 04:46:15,116 IMMUNE SYSTEM, VERSUS NOW WE'RE 6914 04:46:15,116 --> 04:46:19,720 JUST DEALING WITH HOW DO WE 6915 04:46:19,720 --> 04:46:23,124 CONTROL AN IMMUNE -- A SYSTEM 6916 04:46:23,124 --> 04:46:25,626 RESPONSE WITH THE ADAPTIVE 6917 04:46:25,626 --> 04:46:28,029 IMMUNE SYSTEM ACTIVATION. 6918 04:46:28,029 --> 04:46:29,197 SO, THAT THERE'S THIS PROCESS, 6919 04:46:29,197 --> 04:46:33,734 IN THE CASE OF THE BRAIN, OF 6920 04:46:33,734 --> 04:46:35,803 CATABOLISM OF WHITE MATTER, 6921 04:46:35,803 --> 04:46:37,471 CONSTANT GENERATION OF MYELIN 6922 04:46:37,471 --> 04:46:40,441 DEBRIS, AND THAT THE ADAPTIVE 6923 04:46:40,441 --> 04:46:41,976 IMMUNE SYSTEM IS TAKING CARE OF 6924 04:46:41,976 --> 04:46:42,210 THAT. 6925 04:46:42,210 --> 04:46:44,912 I SUSPECT THAT THAT MAY BE THE 6926 04:46:44,912 --> 04:46:46,781 CASE IN CARDIOVASCULAR DISEASE 6927 04:46:46,781 --> 04:46:47,215 AS WELL. 6928 04:46:47,215 --> 04:46:49,183 AND IT WOULD BE INTERESTING TO 6929 04:46:49,183 --> 04:46:50,651 KNOW WHETHER YOU HAVE ANY 6930 04:46:50,651 --> 04:46:52,486 KNOWLEDGE AROUND WHETHER THAT'S 6931 04:46:52,486 --> 04:46:53,454 TRUE IN BONE. 6932 04:46:53,454 --> 04:46:53,988 >> I DON'T. 6933 04:46:53,988 --> 04:46:56,757 I THINK FOR MOST OF THE 6934 04:46:56,757 --> 04:46:59,260 DISEASES, WHERE THERE MIGHT BE 6935 04:46:59,260 --> 04:46:59,927 IMMUNE ACTIVATION, THE 6936 04:46:59,927 --> 04:47:02,864 MEDICATIONS USED TO MANAGE THAT 6937 04:47:02,864 --> 04:47:05,499 ARE SO HARMFUL TO BONE THAT 6938 04:47:05,499 --> 04:47:06,500 MAKING IT DIFFICULT. 6939 04:47:06,500 --> 04:47:10,438 WITH RESPECT TO THE DURATION 6940 04:47:10,438 --> 04:47:13,674 ISSUE, I THINK THAT -- SO 6941 04:47:13,674 --> 04:47:19,146 ESTROGEN IS NOT -- YOU KNOW, A 6942 04:47:19,146 --> 04:47:20,181 MORTALITY TRUCK. 6943 04:47:20,181 --> 04:47:22,350 IT PROMOTES HEALTHY AGING. 6944 04:47:22,350 --> 04:47:25,720 BUT THERE'S -- WHAT WE FOUND IS 6945 04:47:25,720 --> 04:47:28,022 THREE PROGRAMMING OF AGING, 6946 04:47:28,022 --> 04:47:29,457 EARLY CHRONOLOGICAL AGING, 6947 04:47:29,457 --> 04:47:32,493 ENDOCRINE AGING, THERE'S LATE 6948 04:47:32,493 --> 04:47:34,128 CHRONOLOGICAL AGING. 6949 04:47:34,128 --> 04:47:39,066 AND WHAT OUR WORK HAS SHOWN, AND 6950 04:47:39,066 --> 04:47:41,035 HOWARD'S AND I KNOW SHERRI ANN, 6951 04:47:41,035 --> 04:47:44,005 ESTROGEN THERAPY AT THE TIME OF 6952 04:47:44,005 --> 04:47:45,406 MENOPAUSAL SYMPTOMS CHANGES THE 6953 04:47:45,406 --> 04:47:51,345 TRAJECTORY OF AGING. 6954 04:47:51,345 --> 04:47:54,282 SO, IT'S NOT -- WE ALL CROSS 6955 04:47:54,282 --> 04:47:54,715 OVER. 6956 04:47:54,715 --> 04:47:59,453 WE ALL HAVE A LIFESPAN. 6957 04:47:59,453 --> 04:48:00,988 AND ESTROGEN SUSTAINS IN MANY 6958 04:48:00,988 --> 04:48:03,291 RESPECTS THAT ABILITY TO AGE 6959 04:48:03,291 --> 04:48:03,624 WELL. 6960 04:48:03,624 --> 04:48:07,194 BUT THEN THERE'S THE AGING 6961 04:48:07,194 --> 04:48:08,963 PROGRAMS, RIGHT? 6962 04:48:08,963 --> 04:48:12,900 AND THAT'S A VERY DIFFERENT SET 6963 04:48:12,900 --> 04:48:17,471 OF PROGRAMS THAT CAN BE 6964 04:48:17,471 --> 04:48:20,474 MODIFIABLE THROUGH EXERCISE, AS 6965 04:48:20,474 --> 04:48:21,575 WELL AS DIET. 6966 04:48:21,575 --> 04:48:28,049 SO THERE ARE THREE -- AT LEAST 6967 04:48:28,049 --> 04:48:30,885 THREE AGING PROGRAMS. 6968 04:48:30,885 --> 04:48:32,620 >> THE AGING HYPOTHESIS EXISTS 6969 04:48:32,620 --> 04:48:34,422 FOR BREAST CANCER, EXACT 6970 04:48:34,422 --> 04:48:35,056 OPPOSITE DIRECTION. 6971 04:48:35,056 --> 04:48:38,225 I WONDER IF YOU WANT TO COMMENT 6972 04:48:38,225 --> 04:48:39,427 ABOUT THAT? 6973 04:48:39,427 --> 04:48:41,529 BECAUSE EARLIER ONES AGAIN 6974 04:48:41,529 --> 04:48:43,264 HORMONE THERAPY AFTER MENOPAUSE, 6975 04:48:43,264 --> 04:48:46,000 THE HIGHER THE RELATIVE RISK IS. 6976 04:48:46,000 --> 04:48:48,002 AND THAT IS ONE OF THE REASONS 6977 04:48:48,002 --> 04:48:49,937 IT'S CHALLENGING FOR YOUNGER 6978 04:48:49,937 --> 04:48:54,108 WOMEN TO MAKE THESE DECISIONS 6979 04:48:54,108 --> 04:48:56,310 BECAUSE OF THE COLLECTION OF 6980 04:48:56,310 --> 04:48:57,411 OUTCOMES AFFECTED BY ESTROGEN, 6981 04:48:57,411 --> 04:49:00,114 ONE REASON WOMEN'S HEALTH 6982 04:49:00,114 --> 04:49:01,549 INITIATIVE POPULATION WAS SKEWED 6983 04:49:01,549 --> 04:49:04,285 A LITTLE BIT HIGHER WAS TO MAKE 6984 04:49:04,285 --> 04:49:08,022 SURE THAT ADVERSE EFFECTS ON 6985 04:49:08,022 --> 04:49:09,423 BREAST CANCER WEREN'T -- BEFORE 6986 04:49:09,423 --> 04:49:14,261 WE COULD SEE EXPECTED BENEFITS 6987 04:49:14,261 --> 04:49:15,129 ON CARDIOVASCULAR DISEASE, 6988 04:49:15,129 --> 04:49:16,230 BECAUSE CARDIOVASCULAR DISEASE 6989 04:49:16,230 --> 04:49:18,733 IS VERY RARE AMONG WOMEN IN 6990 04:49:18,733 --> 04:49:19,166 THEIR 50s. 6991 04:49:19,166 --> 04:49:22,870 >> SO WE DID AN ANALYSIS, 6992 04:49:22,870 --> 04:49:26,307 FOCUSING FROM A MORE NEUROLOGIC 6993 04:49:26,307 --> 04:49:28,275 PERSPECTIVE BUT WE ASKED THE 6994 04:49:28,275 --> 04:49:29,343 QUESTION, ARE THERE DIFFERENCES 6995 04:49:29,343 --> 04:49:39,787 IN THE PROGESTINS, FROM A 6996 04:49:41,789 --> 04:49:43,424 NEUROLOGIC PROGRESSION. 6997 04:49:43,424 --> 04:49:47,294 THE OTHER PROGESTINS, IF YOU DO 6998 04:49:47,294 --> 04:49:48,929 CONTINUOUS COMBINED HORMONE 6999 04:49:48,929 --> 04:49:54,201 THERAPY WHERE ESTROGEN PLUS 7000 04:49:54,201 --> 04:49:58,139 PROGESTIN, THAT IS AFFECTED IN 7001 04:49:58,139 --> 04:50:00,007 INHIBITING ESTROGEN ACTION. 7002 04:50:00,007 --> 04:50:02,410 IN MULTIPLE ORGANS, INCLUDING 7003 04:50:02,410 --> 04:50:03,844 THE BRAIN. 7004 04:50:03,844 --> 04:50:07,748 THE NORMAL BIOLOGY HAS ESTROGEN 7005 04:50:07,748 --> 04:50:09,183 RISING, DECLINING, AND THEN 7006 04:50:09,183 --> 04:50:11,919 PROGESTERONE COMING ON. 7007 04:50:11,919 --> 04:50:15,222 WHEN THE HORMONE THERAPY IS 7008 04:50:15,222 --> 04:50:16,057 CONSISTENT WITH THAT NATURAL -- 7009 04:50:16,057 --> 04:50:18,192 WITH THE DESIGN OF THE SYSTEM, 7010 04:50:18,192 --> 04:50:20,361 THEN THERE IS BENEFIT. 7011 04:50:20,361 --> 04:50:22,096 WHEN IT'S CONTINUOUS COMBINED, 7012 04:50:22,096 --> 04:50:22,863 IT'S INHIBITORY. 7013 04:50:22,863 --> 04:50:28,702 NOW, THAT WORKS WELL IN THE 7014 04:50:28,702 --> 04:50:32,740 UTERUS, EXCEPT FOR HYDROXY 7015 04:50:32,740 --> 04:50:37,111 PROGESTERONE ACETATE, IT DRIVES 7016 04:50:37,111 --> 04:50:40,347 PROLIFERATION OF THE CELLS, AND 7017 04:50:40,347 --> 04:50:43,484 IT RELIES ON CELL CYCLE 7018 04:50:43,484 --> 04:50:44,819 CHECKPOINT PROGRAMS. 7019 04:50:44,819 --> 04:50:46,654 SO IT'S DRIVING ALL OF THIS 7020 04:50:46,654 --> 04:50:47,421 PROLIFERATION AND HOPING THAT 7021 04:50:47,421 --> 04:50:50,357 THERE WILL BE A CHECK POINT. 7022 04:50:50,357 --> 04:50:53,994 THAT'S THE SAME CHECKPOINT 7023 04:50:53,994 --> 04:50:55,396 ACTIVATION, THE SAME IN BREAST, 7024 04:50:55,396 --> 04:50:56,397 RIGHT? 7025 04:50:56,397 --> 04:50:58,799 SO I REALLY THINK THE PROGESTIN, 7026 04:50:58,799 --> 04:51:03,404 THE TYPE OF PROGESTIN REALLY 7027 04:51:03,404 --> 04:51:05,473 MATTERS, AND HOWARD, I THINK 7028 04:51:05,473 --> 04:51:06,340 YOU'RE MORE KNOWLEDGEABLE AROUND 7029 04:51:06,340 --> 04:51:06,574 THAT. 7030 04:51:06,574 --> 04:51:10,177 >> I THINK THE TYPE MATTERS, AND 7031 04:51:10,177 --> 04:51:12,480 AS YOU SUGGESTED, SO IS THE 7032 04:51:12,480 --> 04:51:17,084 PATTERN THAT YOU ADMINISTER IT. 7033 04:51:17,084 --> 04:51:18,319 LIKELY SAFER TO FOLLOW BIOLOGY 7034 04:51:18,319 --> 04:51:21,555 BUT, AGAIN, THIS IS A BIG AREA 7035 04:51:21,555 --> 04:51:24,625 THAT WE DON'T KNOW FOR SURE. 7036 04:51:24,625 --> 04:51:28,562 THERE'S NOT ENOUGH DATA, NOT 7037 04:51:28,562 --> 04:51:29,430 ENOUGH STUDIES. 7038 04:51:29,430 --> 04:51:30,631 >> TO DOVETAIL ON YOUR QUESTION, 7039 04:51:30,631 --> 04:51:37,538 WE ASKED THE QUESTION, BECAUSE 7040 04:51:37,538 --> 04:51:39,940 WE FOUND ESTROGEN THERAPY 7041 04:51:39,940 --> 04:51:44,979 REDUCES RISK OF DEVELOPING 7042 04:51:44,979 --> 04:51:47,481 ALZHEIMER'S, ALS, MULTIPLE 7043 04:51:47,481 --> 04:51:48,149 SCLEROSIS AND PARKINSON'S 7044 04:51:48,149 --> 04:51:50,751 WHENNED A ALL -- WHEN 7045 04:51:50,751 --> 04:51:52,620 ADMINISTERED AT THE RIGHT TIME, 7046 04:51:52,620 --> 04:51:54,922 WHETHER THERE'S AN IMPACT ON 7047 04:51:54,922 --> 04:51:56,357 THIS TIMING OF INITIATION, AND 7048 04:51:56,357 --> 04:51:58,626 MOSTLY WHAT WE FIND IS THAT 7049 04:51:58,626 --> 04:51:59,727 THERE ISN'T. 7050 04:51:59,727 --> 04:52:03,130 THERE'S NO BENEFIT, THERE'S NO 7051 04:52:03,130 --> 04:52:03,497 HARM. 7052 04:52:03,497 --> 04:52:07,301 I'M NOT SURE WHY WOMEN ARE 7053 04:52:07,301 --> 04:52:08,936 ADMINISTERED HORMONE THERAPY SO 7054 04:52:08,936 --> 04:52:09,136 LATE. 7055 04:52:09,136 --> 04:52:10,604 I KNOW THAT IN THE CLINICAL 7056 04:52:10,604 --> 04:52:14,808 TRIALS IT WAS SO THAT NO ONE 7057 04:52:14,808 --> 04:52:16,377 WOULD BE UNBLINDED TO THE 7058 04:52:16,377 --> 04:52:17,244 INTERVENTION, RIGHT? 7059 04:52:17,244 --> 04:52:21,282 SO IF A WOMAN HAD HOT FLASHES 7060 04:52:21,282 --> 04:52:24,585 AND SHE'S RANDOMIZED TO AN 7061 04:52:24,585 --> 04:52:25,886 ESTROGEN, THEN EVERYBODY'S 7062 04:52:25,886 --> 04:52:28,155 UNBLINDED INCLUDING PARTICIPANT. 7063 04:52:28,155 --> 04:52:30,791 SO I THINK THERE ARE, YOU KNOW, 7064 04:52:30,791 --> 04:52:34,528 ISSUES AROUND THOSE DESIGNS THAT 7065 04:52:34,528 --> 04:52:39,066 ARE CRITICAL, TO CONSIDERING THE 7066 04:52:39,066 --> 04:52:39,333 DATA. 7067 04:52:39,333 --> 04:52:41,669 I DON'T KNOW, SHERRI ANN -- 7068 04:52:41,669 --> 04:52:43,070 >> YOUNGER WOMEN DON'T HAVE THE 7069 04:52:43,070 --> 04:52:44,605 CLINICAL EVENTS SO YOU CAN'T SEE 7070 04:52:44,605 --> 04:52:49,310 DIFFERENCE IN ANY OF THESE 7071 04:52:49,310 --> 04:52:50,177 FRACTURES, WHATEVER, IN 7072 04:52:50,177 --> 04:52:51,278 50-YEAR-OLDS, WITHOUT DOING TEN 7073 04:52:51,278 --> 04:52:52,479 TIMES AS MANY PEOPLE. 7074 04:52:52,479 --> 04:52:54,582 >> WE ASKED THE QUESTION, WE 7075 04:52:54,582 --> 04:52:56,450 WENT AND ADDRESSED FROM A 7076 04:52:56,450 --> 04:52:59,286 NEUROLOGICAL PERSPECTIVE WHAT IS 7077 04:52:59,286 --> 04:53:02,990 THE IMPACT OF PHARMACOLOGICAL 7078 04:53:02,990 --> 04:53:05,826 BREAST CANCER THERAPIES, 7079 04:53:05,826 --> 04:53:07,695 TAMOXIFEN, RALOXIFENE, AROMATASE 7080 04:53:07,695 --> 04:53:07,995 INHIBITORS. 7081 04:53:07,995 --> 04:53:15,569 WE FOUND THAT THE AROMATASE 7082 04:53:15,569 --> 04:53:17,972 INHIBITIERS AND TAMOXIFEN REDUCE 7083 04:53:17,972 --> 04:53:20,908 RISK OF DEVELOPING 7084 04:53:20,908 --> 04:53:21,842 AGE-ASSOCIATED NEURODEGENERATIVE 7085 04:53:21,842 --> 04:53:23,877 DISEASE, HALF AT FULL ESTROGEN. 7086 04:53:23,877 --> 04:53:25,646 RALOXIFENE DID NOT. 7087 04:53:25,646 --> 04:53:27,514 IT'S NOT BECAUSE RALOXIFENE 7088 04:53:27,514 --> 04:53:29,917 ISN'T EFFECTIVE IN A PETRI DISH, 7089 04:53:29,917 --> 04:53:33,954 A MILD ESTROGEN AGONIST. 7090 04:53:33,954 --> 04:53:35,823 IT DOESN'T CROSS THE BLOOD-BRAIN 7091 04:53:35,823 --> 04:53:36,590 BARRIER AT CLINICAL 7092 04:53:36,590 --> 04:53:37,558 CONCENTRATIONS. 7093 04:53:37,558 --> 04:53:41,495 IF YOU DOUBLE THAT, THEN YOU'LL 7094 04:53:41,495 --> 04:53:45,099 GET RALOXIFENE IN THE BRAIN. 7095 04:53:45,099 --> 04:53:47,501 QUITE SURPRISING TO ME 7096 04:53:47,501 --> 04:53:49,303 PARTICULARLY AROMATASE 7097 04:53:49,303 --> 04:53:52,473 INHIBITORS ARE ACTING AS A WEAK 7098 04:53:52,473 --> 04:53:53,774 ESTROGEN AGONIST IN BRAIN. 7099 04:53:53,774 --> 04:53:55,209 I WOULD HAVE NEVER PREDICTED 7100 04:53:55,209 --> 04:53:57,478 THAT. 7101 04:53:57,478 --> 04:54:02,416 7102 04:54:02,416 --> 04:54:04,818 >> DR. HODIS WAS KIND ENOUGH TO 7103 04:54:04,818 --> 04:54:06,787 MENTION ESTROGEN EFFECT ON 7104 04:54:06,787 --> 04:54:08,856 BREAST CANCER PROTECTIVE, 7105 04:54:08,856 --> 04:54:11,592 DISAPPEAR IN YOUNGER WOMEN, ONLY 7106 04:54:11,592 --> 04:54:13,560 IN OLDER ONES. 7107 04:54:13,560 --> 04:54:16,664 THE TIMING HYPOTHESIS APPLIES TO 7108 04:54:16,664 --> 04:54:18,866 ESTROGEN ALONE AS WELL. 7109 04:54:18,866 --> 04:54:21,235 >> THEY DISAPPEAR THROUGH THE 7110 04:54:21,235 --> 04:54:21,702 INTERVENTION? 7111 04:54:21,702 --> 04:54:25,839 >> IF YOU LOOK BY AGE. 7112 04:54:25,839 --> 04:54:27,474 >> I'M TALKING ABOUT WOMEN 7113 04:54:27,474 --> 04:54:28,809 YOUNGER THAN 60. 7114 04:54:28,809 --> 04:54:30,110 >> YES, THERE'S NO BENEFIT IN 7115 04:54:30,110 --> 04:54:33,314 THE YOUNGER WOMEN. 7116 04:54:33,314 --> 04:54:36,116 >> BUT OVERALL IN THAT STUDY THE 7117 04:54:36,116 --> 04:54:41,221 REDUCTION WAS MUCH MORE 7118 04:54:41,221 --> 04:54:43,590 SIGNIFICANT FOR DCIS AND SO I 7119 04:54:43,590 --> 04:54:46,060 MEAN I DON'T -- BOTTOM LINE IS 7120 04:54:46,060 --> 04:54:48,395 IT REDUCED IT IN THE TRIALS, 7121 04:54:48,395 --> 04:54:50,698 DURING INTERVENTION, AND 7122 04:54:50,698 --> 04:54:54,435 CERTAINLY DIDN'T INCREASE IT. 7123 04:54:54,435 --> 04:54:55,502 >> ABSOLUTELY, THE TIMING 7124 04:54:55,502 --> 04:54:56,236 HYPOTHESIS -- 7125 04:54:56,236 --> 04:54:56,937 >> WHICH IS REALLY INTERESTING 7126 04:54:56,937 --> 04:55:01,108 BECAUSE OF COURSE THAT'S WHERE 7127 04:55:01,108 --> 04:55:11,485 THIS WHOLE KERFUFLE 7128 04:55:12,553 --> 04:55:14,555 MPA MUST BE THE BAD PLAYER, I'M 7129 04:55:14,555 --> 04:55:15,522 NOT CONVINCED OF IT. 7130 04:55:15,522 --> 04:55:16,757 >> I AM. 7131 04:55:16,757 --> 04:55:18,826 >> AS ROBBIE SAYS, ALL THE 7132 04:55:18,826 --> 04:55:20,461 DIFFERENT FORMULATIONS AND I 7133 04:55:20,461 --> 04:55:23,964 THINK WE NEED DEFINITIVE STUDIES 7134 04:55:23,964 --> 04:55:27,368 TO ACTUALLY UNDERSTAND THAT. 7135 04:55:27,368 --> 04:55:29,870 I DON'T THINK THAT TISSUE 7136 04:55:29,870 --> 04:55:31,405 CULTURE STUDIES AND ANIMAL 7137 04:55:31,405 --> 04:55:33,507 STUDIES GIVE US THE ANSWERS. 7138 04:55:33,507 --> 04:55:34,575 WE'VE BEEN BURNED. 7139 04:55:34,575 --> 04:55:36,777 WE'VE BEEN BURNED WAY TOO MANY 7140 04:55:36,777 --> 04:55:37,111 TIMES. 7141 04:55:37,111 --> 04:55:39,813 >> I'LL BE STRICT TIME KEEPER 7142 04:55:39,813 --> 04:55:42,116 HERE AND GIVE DR. CRESWELL THE 7143 04:55:42,116 --> 04:55:43,550 LAST QUESTION AND WE'LL MOVE ON. 7144 04:55:43,550 --> 04:55:45,753 >> THIS HAS BEEN A GREAT PANEL. 7145 04:55:45,753 --> 04:55:47,054 I THINK ACTUALLY THIS 7146 04:55:47,054 --> 04:55:47,688 ILLUSTRATES SOME CHALLENGES 7147 04:55:47,688 --> 04:55:49,890 WE'RE GOING TO HAVE IN THE 7148 04:55:49,890 --> 04:55:50,991 WOMEN'S HEALTH RESEARCH 7149 04:55:50,991 --> 04:55:54,928 INITIATIVE AND ALSO IN ACHIEVING 7150 04:55:54,928 --> 04:55:57,097 THE GOALS DR. BERTAGNOLLI 7151 04:55:57,097 --> 04:55:57,998 OUTLINED. 7152 04:55:57,998 --> 04:56:01,702 I'LL USE OSTEOPOROSIS AS AN 7153 04:56:01,702 --> 04:56:02,703 EXAMPLE. 7154 04:56:02,703 --> 04:56:05,439 THERE WERE GREAT STRIDES IN 7155 04:56:05,439 --> 04:56:15,182 TERMS OF DECREASING FRACTURES 7156 04:56:15,182 --> 04:56:16,216 WITH BISPHOSPHONATE. 7157 04:56:16,216 --> 04:56:18,252 THERE WAS AN ARTICLE IN THE "NEW 7158 04:56:18,252 --> 04:56:20,554 YORK TIMES," AND THIS DRAMATIC 7159 04:56:20,554 --> 04:56:25,325 DECREASE IN USE, AND THEN THE 7160 04:56:25,325 --> 04:56:26,427 RATE OF FRACTURES STARTED 7161 04:56:26,427 --> 04:56:26,727 INCREASING. 7162 04:56:26,727 --> 04:56:29,596 HOW DO WE UNDERSTAND MORE ABOUT 7163 04:56:29,596 --> 04:56:31,598 THESE RARE SIDE EFFECTS WHICH 7164 04:56:31,598 --> 04:56:33,333 PEOPLE, ET CETERA, ARE RARE, 7165 04:56:33,333 --> 04:56:34,601 IT'S BEEN VIRTUALLY IMPOSSIBLE 7166 04:56:34,601 --> 04:56:37,538 TO STUDIES THESE IN A RIGOROUS 7167 04:56:37,538 --> 04:56:40,240 WAY SO THINGS TO SOLVE ON THAT 7168 04:56:40,240 --> 04:56:40,574 FRONT. 7169 04:56:40,574 --> 04:56:43,076 IN THE MEANTIME, VERY SOLID 7170 04:56:43,076 --> 04:56:44,945 EVIDENCE INDICATES THAT WOMEN 7171 04:56:44,945 --> 04:56:47,815 WHO ALREADY HAVE ONE 7172 04:56:47,815 --> 04:56:48,449 OSTEOPOROTIC FRACTURE, EXTREMELY 7173 04:56:48,449 --> 04:56:51,952 INCREASED RISK FOR HAVING A 7174 04:56:51,952 --> 04:56:54,154 SECOND, THIS HAS PROMPTED 7175 04:56:54,154 --> 04:56:55,889 MEDICAL CLINICAL TEAMS TO 7176 04:56:55,889 --> 04:56:56,657 DEVELOP FRACTURE LIAISON 7177 04:56:56,657 --> 04:56:58,192 SERVICES TO IDENTIFY THESE WOMEN 7178 04:56:58,192 --> 04:56:59,593 AT GREAT RISK IN THE HOSPITAL. 7179 04:56:59,593 --> 04:57:01,695 THE PROBLEM IS THOSE SERVICES 7180 04:57:01,695 --> 04:57:02,996 AREN'T REIMBURSED. 7181 04:57:02,996 --> 04:57:04,431 SO THERE'S BEEN THIS 7182 04:57:04,431 --> 04:57:06,934 LONGSTANDING EFFORT TO TRY TO 7183 04:57:06,934 --> 04:57:08,802 GET THAT REIMBURSED SO THIS CARE 7184 04:57:08,802 --> 04:57:10,571 THAT WE KNOW WILL MAKE A 7185 04:57:10,571 --> 04:57:13,173 DIFFERENCE CAN BE DELIVERED TO 7186 04:57:13,173 --> 04:57:13,407 PEOPLE. 7187 04:57:13,407 --> 04:57:14,374 WE HAVE ANOTHER PROBLEM, IF YOU 7188 04:57:14,374 --> 04:57:17,344 WANT TO DEVELOP NEW DRUGS TO 7189 04:57:17,344 --> 04:57:18,979 PREVENT OSTEOPOROSIS, IT TAKES A 7190 04:57:18,979 --> 04:57:20,180 LONG TIME TO OBSERVE OUTCOMES 7191 04:57:20,180 --> 04:57:24,985 LIKE WE WERE JUST DISCUSSING 7192 04:57:24,985 --> 04:57:25,219 HERE. 7193 04:57:25,219 --> 04:57:27,287 ARE THERE GOOD BIOMARKERS OR 7194 04:57:27,287 --> 04:57:28,755 PROXIES FOR FRACTURE? 7195 04:57:28,755 --> 04:57:33,093 THERE'S BEEN A LOT OF ADVOCACY, 7196 04:57:33,093 --> 04:57:36,163 LIKE A DECADE FOR THE FDA TO 7197 04:57:36,163 --> 04:57:38,232 APPROVAL ONE TRIAL TO USE BONE 7198 04:57:38,232 --> 04:57:42,169 MINERAL DENSITY AS A PROXY. 7199 04:57:42,169 --> 04:57:44,805 HERE'S A COMMON PROBLEM, SO 7200 04:57:44,805 --> 04:57:45,172 MULTI-FACTORIAL. 7201 04:57:45,172 --> 04:57:48,075 WE HAVE BIG CHALLENGES TO TRY TO 7202 04:57:48,075 --> 04:57:50,143 REALLY MAKE A DIFFERENCE IN 7203 04:57:50,143 --> 04:57:51,345 DELIVERING IMPROVED HEALTH TO 7204 04:57:51,345 --> 04:57:51,879 PEOPLE. 7205 04:57:51,879 --> 04:57:53,313 SO I THOUGHT THIS WAS A 7206 04:57:53,313 --> 04:57:55,282 FANTASTIC GROUP OF TALKS TO 7207 04:57:55,282 --> 04:57:56,717 ILLUSTRATE THE SCIENCE AS WELL 7208 04:57:56,717 --> 04:57:58,452 AS THESE BIGGER POLICY ISSUES. 7209 04:57:58,452 --> 04:58:02,523 THANK YOU FOR ORGANIZING THIS. 7210 04:58:02,523 --> 04:58:05,926 >> THANK YOU TO OUR SPEAKERS. 7211 04:58:05,926 --> 04:58:10,163 7212 04:58:10,163 --> 04:58:11,331 7213 04:58:11,331 --> 04:58:13,767 >> THANK YOU. 7214 04:58:13,767 --> 04:58:14,234 BRAVO. 7215 04:58:14,234 --> 04:58:16,136 IT WAS A GREAT PRESENTATION. 7216 04:58:16,136 --> 04:58:19,172 I'D LIKE TO INVITE DR. CLAYTON 7217 04:58:19,172 --> 04:58:20,674 TO INTRODUCE OUR NEXT SPEAKER. 7218 04:58:20,674 --> 04:58:24,978 >> LET ME ADD MY THANKS TO THE 7219 04:58:24,978 --> 04:58:27,047 PANELISTS, AND DR. DUTTA FOR AN 7220 04:58:27,047 --> 04:58:31,552 INCREDIBLE PANEL. 7221 04:58:31,552 --> 04:58:33,186 DR. CRISWELL HIGHLIGHTED 7222 04:58:33,186 --> 04:58:34,421 CHALLENGES, DR. ANDERSON ASKED 7223 04:58:34,421 --> 04:58:35,622 MANY QUESTIONS WE DON'T HAVE THE 7224 04:58:35,622 --> 04:58:37,124 ANSWERS TO. 7225 04:58:37,124 --> 04:58:37,558 THANK YOU ALL. 7226 04:58:37,558 --> 04:58:40,494 I'D LIKE TO INTRODUCE OUR NEXT 7227 04:58:40,494 --> 04:58:47,401 SPEAKER, DR. VICTORIA SHANMUGAM, 7228 04:58:47,401 --> 04:58:49,803 ORWH, I MENTIONED HER EARLIER 7229 04:58:49,803 --> 04:58:52,873 TODAY WHEN I INTRODUCED HER 7230 04:58:52,873 --> 04:58:56,376 JOINING ORWH LEADERSHIP, SHE'S A 7231 04:58:56,376 --> 04:58:58,345 PHYSICAL EXAMINATION SCIENTIST, 7232 04:58:58,345 --> 04:59:00,047 RHEUMATOLOGIST, HAS LED THE 7233 04:59:00,047 --> 04:59:01,615 RHEUMATOLOGY FELLOWSHIP AT 7234 04:59:01,615 --> 04:59:03,717 GEORGETOWN UNIVERSITY, ALSO WAS 7235 04:59:03,717 --> 04:59:05,252 FACULTY AT GEORGE WASHINGTON 7236 04:59:05,252 --> 04:59:05,652 UNIVERSITY. 7237 04:59:05,652 --> 04:59:07,988 AND I THINK WE'VE GOT HER SLIDES 7238 04:59:07,988 --> 04:59:11,391 CUED UP HERE IN ONE SECOND. 7239 04:59:11,391 --> 04:59:13,994 THERE WE GO. 7240 04:59:13,994 --> 04:59:20,033 7241 04:59:20,033 --> 04:59:24,171 7242 04:59:24,171 --> 04:59:25,172 >> THANK YOU. 7243 04:59:25,172 --> 04:59:28,642 WE SAVED THE BEST FOR LAST FOR 7244 04:59:28,642 --> 04:59:29,042 YOU. 7245 04:59:29,042 --> 04:59:30,944 SO, THANK YOU, EVERYONE. 7246 04:59:30,944 --> 04:59:32,579 THANKS FOR THE INTRODUCTION, DR. 7247 04:59:32,579 --> 04:59:33,780 CLAYTON. 7248 04:59:33,780 --> 04:59:36,617 I'M HERE TO PRESENT TODAY A 7249 04:59:36,617 --> 04:59:39,152 REQUEST FOR YOU TO VOTE ON A 7250 04:59:39,152 --> 04:59:40,687 POTENTIAL NOTICE OF SPECIAL 7251 04:59:40,687 --> 04:59:43,223 INTEREST, LOOKING TO BUILD 7252 04:59:43,223 --> 04:59:44,758 CONSENSUS FOR AUTOIMMUNE 7253 04:59:44,758 --> 04:59:45,592 DISEASE-RELATED COMMON DATA 7254 04:59:45,592 --> 04:59:45,859 ELEMENTS. 7255 04:59:45,859 --> 04:59:49,262 SO THIS WOULD BE A NEW CONCEPT 7256 04:59:49,262 --> 04:59:51,231 CLEARANCE, THE PURPOSE TO 7257 04:59:51,231 --> 04:59:59,239 HIGHLIGHT OUR INTEREST IN OFFICE 7258 04:59:59,239 --> 05:00:00,974 OF AUTOIMMUNE DISEASE RESEARCH, 7259 05:00:00,974 --> 05:00:02,175 APPLICABLE TO AUTOIMMUNE 7260 05:00:02,175 --> 05:00:04,244 DISEASES, AND TO REALLY USE THIS 7261 05:00:04,244 --> 05:00:07,414 TOOL TO CONVENE MEMBERS OF THE 7262 05:00:07,414 --> 05:00:09,950 SCIENTIFIC, CLINICAL, PATIENT, 7263 05:00:09,950 --> 05:00:12,252 AND ADVOCACY COMMUNITY TO INFORM 7264 05:00:12,252 --> 05:00:13,654 DISCUSSIONS AND IDENTIFY 7265 05:00:13,654 --> 05:00:14,321 APPROPRIATE COMMON DATA ELEMENTS 7266 05:00:14,321 --> 05:00:16,857 TO INCLUDE A MOVE TO 7267 05:00:16,857 --> 05:00:18,458 ENDORSEMENT, THIS WILL OBVIOUSLY 7268 05:00:18,458 --> 05:00:20,861 BE SUBJECT TO AVAILABILITY OF 7269 05:00:20,861 --> 05:00:22,963 FUNDS, AND COLLABORATION WITH 7270 05:00:22,963 --> 05:00:25,932 THE VARIOUS ICOS IN ORDER TO 7271 05:00:25,932 --> 05:00:29,436 MAKE THIS HAPPEN, AND IT'S 7272 05:00:29,436 --> 05:00:31,304 EXPECTED THESE WOULD EACH BE 7273 05:00:31,304 --> 05:00:33,240 AWARDED FOR ONE SINGLE YEAR. 7274 05:00:33,240 --> 05:00:35,342 WHAT WE'RE ASKING AFTER I 7275 05:00:35,342 --> 05:00:39,913 PRESENT IS A VOTE TO APPROVE THE 7276 05:00:39,913 --> 05:00:42,015 CONCEPT FOR BUILD CONSENSUS FOR 7277 05:00:42,015 --> 05:00:43,650 COMMON DISEASE RELATED ELEMENTS. 7278 05:00:43,650 --> 05:00:45,419 TO GIVE THE BACKGROUND, I FEEL 7279 05:00:45,419 --> 05:00:46,586 LIKE THE SPEAKERS THROUGHOUT 7280 05:00:46,586 --> 05:00:48,689 TODAY HAVE LINED ME UP NICELY 7281 05:00:48,689 --> 05:00:51,425 FOR THIS DISCUSSION, AS YOU KNOW 7282 05:00:51,425 --> 05:00:53,727 AUTOIMMUNE DISEASES ARE RATHER 7283 05:00:53,727 --> 05:00:54,094 COMMON. 7284 05:00:54,094 --> 05:00:58,331 APPROXIMATELY 7 TO 8% OF THE 7285 05:00:58,331 --> 05:00:59,800 POPULATION, ABOUT 23.5 MILLION 7286 05:00:59,800 --> 05:01:02,035 AMERICANS ARE AFFECTED BY 7287 05:01:02,035 --> 05:01:03,804 AUTOIMMUNE DISEASES, THAT'S 7288 05:01:03,804 --> 05:01:05,706 PROBABLY AN UNDERESTIMATE. 7289 05:01:05,706 --> 05:01:09,710 IN CONTEXT, AT THE END OF 2021, 7290 05:01:09,710 --> 05:01:11,044 THERE WERE 1.2 MILLION PEOPLE 7291 05:01:11,044 --> 05:01:14,314 LIVING WITH HIV IN THE UNITED 7292 05:01:14,314 --> 05:01:14,548 STATES. 7293 05:01:14,548 --> 05:01:16,917 SO 23.5 MILLION PEOPLE ALL 7294 05:01:16,917 --> 05:01:24,357 LIVING WITH AUTOIMMUNE 7295 05:01:24,357 --> 05:01:24,624 DISEASES. 7296 05:01:24,624 --> 05:01:25,892 80% ARE WOMEN, FOUR TIMES MORE 7297 05:01:25,892 --> 05:01:28,095 WOMEN THAN MEN ARE AFFECTED. 7298 05:01:28,095 --> 05:01:30,063 THE REALITY IS THAT THE EXACT 7299 05:01:30,063 --> 05:01:30,597 PREVALENCE OF AUTOIMMUNE 7300 05:01:30,597 --> 05:01:32,499 DISEASES IN THE U.S. IS UNKNOWN 7301 05:01:32,499 --> 05:01:35,202 BECAUSE WE DON'T HAVE ANY GOOD 7302 05:01:35,202 --> 05:01:36,503 LONGITUDINAL DATA REPOSITORY. 7303 05:01:36,503 --> 05:01:40,140 AND SO THIS IS FOUNDATIONAL 7304 05:01:40,140 --> 05:01:41,875 TOWARDS BUILDING THAT. 7305 05:01:41,875 --> 05:01:44,845 THIS IS THE LIST THAT OUR OFFICE 7306 05:01:44,845 --> 05:01:47,347 WAS GIFTED, AS WE BECAME 7307 05:01:47,347 --> 05:01:49,182 ESTABLISHED, LAST YEAR. 7308 05:01:49,182 --> 05:01:50,450 I APPRECIATE THE TYPE IS RATHER 7309 05:01:50,450 --> 05:01:51,318 SMALL. 7310 05:01:51,318 --> 05:01:53,520 IF YOU USE THE QR CODE IT WILL 7311 05:01:53,520 --> 05:01:54,588 TAKE YOU TO THE WEBSITE WHERE 7312 05:01:54,588 --> 05:01:57,324 THERE'S A LARGE PRINT VERSION. 7313 05:01:57,324 --> 05:01:58,759 THERE ARE 144 AUTOIMMUNE 7314 05:01:58,759 --> 05:02:00,193 DISEASES AND RELATED CONDITIONS 7315 05:02:00,193 --> 05:02:01,394 ON THIS LIST. 7316 05:02:01,394 --> 05:02:03,163 SO THERE IS A LOT OF NEED IN 7317 05:02:03,163 --> 05:02:04,030 THIS AREA. 7318 05:02:04,030 --> 05:02:08,502 JUST BY WAY OF BACKGROUND, NIH 7319 05:02:08,502 --> 05:02:10,604 ENDORSED COMMON DATA ELEMENTS, 7320 05:02:10,604 --> 05:02:11,371 STANDARDIZED PRECISELY DEFINED 7321 05:02:11,371 --> 05:02:14,875 QUESTIONS, PAIRED WITH A SET OF 7322 05:02:14,875 --> 05:02:16,309 RESPONSES USED SYSTEMICALLY 7323 05:02:16,309 --> 05:02:18,245 ACROSS DIFFERENT CLINICAL SITES, 7324 05:02:18,245 --> 05:02:19,146 STUDIES, CLINICAL TRIALS, TO 7325 05:02:19,146 --> 05:02:21,214 ENSURE CONSISTENCY OF DATA 7326 05:02:21,214 --> 05:02:22,649 COLLECTION AND DATA 7327 05:02:22,649 --> 05:02:23,617 HARMONIZATION. 7328 05:02:23,617 --> 05:02:25,252 THEY HAVE REALLY BEEN HARMONIZED 7329 05:02:25,252 --> 05:02:27,554 THROUGH A PROJECT AT THE 7330 05:02:27,554 --> 05:02:28,155 NATIONAL LIBRARY OF MEDICINE, 7331 05:02:28,155 --> 05:02:31,625 THIS CODE WILL TAKE YOU TO THEIR 7332 05:02:31,625 --> 05:02:34,027 WEBSITE TO ENSURE THAT THE NIH 7333 05:02:34,027 --> 05:02:36,963 IS ENDORSING COLLECTIONS OF 7334 05:02:36,963 --> 05:02:38,064 CDEs THAT MEET CRITERIA, AND 7335 05:02:38,064 --> 05:02:41,134 PURPOSE OF THAT IS REALLY TO BE 7336 05:02:41,134 --> 05:02:43,436 FOUNDATIONAL IN THIS FOCUS ON 7337 05:02:43,436 --> 05:02:46,173 DATA SHARING, SO WE CAN ACTUALLY 7338 05:02:46,173 --> 05:02:48,241 START TO BUILD BOTH LONGITUDINAL 7339 05:02:48,241 --> 05:02:51,344 REPOSITORIES FOR AUTOIMMUNE 7340 05:02:51,344 --> 05:02:52,946 DISEASE AND FACILITATE DATA 7341 05:02:52,946 --> 05:02:55,382 MANAGEMENT AND SHARING THAT 7342 05:02:55,382 --> 05:02:57,884 WE'RE TRYING TO ACHIEVE. 7343 05:02:57,884 --> 05:03:02,455 SO JUST AS THE BASELINE, THIS IS 7344 05:03:02,455 --> 05:03:04,024 THE CURRENTLY ENDORSED NIH 7345 05:03:04,024 --> 05:03:06,326 COMMON DATA ELEMENTS FOR 7346 05:03:06,326 --> 05:03:08,495 AUTOIMMUNE DISEASE RESEARCH. 7347 05:03:08,495 --> 05:03:10,597 I SHOWED 144 DISEASES, THIS IS 7348 05:03:10,597 --> 05:03:12,465 WHAT WE HAVE ENDORSED CURRENTLY. 7349 05:03:12,465 --> 05:03:15,402 MULTIPLE SCLEROSIS IS DOING 7350 05:03:15,402 --> 05:03:16,503 BETTER THAN MANY OTHERS, QR CODE 7351 05:03:16,503 --> 05:03:18,872 ON THIS SLIDE WILL TAKE YOU TO 7352 05:03:18,872 --> 05:03:22,709 THE SITE WHERE THEY HAVE HAD A 7353 05:03:22,709 --> 05:03:24,811 CONCERTED EFFORT TO BUILDING 7354 05:03:24,811 --> 05:03:26,346 COMMON DATA ELEMENTS IN MULTIPLE 7355 05:03:26,346 --> 05:03:27,280 SCLEROSIS AND IT'S BEEN AN 7356 05:03:27,280 --> 05:03:30,283 EFFORT GOING ON OVER THE COURSE 7357 05:03:30,283 --> 05:03:32,552 OF TEN YEARS THAT SET THEM UP 7358 05:03:32,552 --> 05:03:43,063 WELL FOR LONGITUDINAL STUDIES IN 7359 05:03:43,063 --> 05:03:44,164 MULTIPLE SCLEROSIS. 7360 05:03:44,164 --> 05:03:45,599 EMBARRASSINGLY THERE ARE VERY 7361 05:03:45,599 --> 05:03:47,467 FEW ENDORSED COMMON DATA 7362 05:03:47,467 --> 05:03:50,971 ELEMENTS FOR SOME MORE COMMON 7363 05:03:50,971 --> 05:04:00,847 AUTOIMMUNE DISEASES, INCLUDING 7364 05:04:00,847 --> 05:04:01,815 LUPUS, SCLERODERMA, VASCULITIS, 7365 05:04:01,815 --> 05:04:02,148 VITILIGO. 7366 05:04:02,148 --> 05:04:04,985 WE HAVE LOTS OF EXISTING 7367 05:04:04,985 --> 05:04:05,752 REGISTRIES FOR AUTOIMMUNE 7368 05:04:05,752 --> 05:04:07,621 DISEASE RESEARCH, YOU CAN'T FIT 7369 05:04:07,621 --> 05:04:11,658 THEM ALL ON A SINGLE SLIDE BUT 7370 05:04:11,658 --> 05:04:15,595 THEY RANGE FROM REGISTRIES 7371 05:04:15,595 --> 05:04:17,697 FOCUSED ON RHEUMATOID ARTHRITIS, 7372 05:04:17,697 --> 05:04:18,899 INFLAMMATORY BOWEL DISEASE, 7373 05:04:18,899 --> 05:04:21,968 REGISTRIES IN THE V.A., 7374 05:04:21,968 --> 05:04:24,938 REGISTRIES FOCUSED ON CLINICAL 7375 05:04:24,938 --> 05:04:26,106 TRIALS, SO PART OF THE WORK WE 7376 05:04:26,106 --> 05:04:30,176 NEED TO DO IS TRYING TO 7377 05:04:30,176 --> 05:04:31,912 HARMONIZE DATA ELEMENTS TO MOVE 7378 05:04:31,912 --> 05:04:37,150 FORWARD IN TERMS OF ADVANCING 7379 05:04:37,150 --> 05:04:38,585 AUTOIMMUNE DISEASE RESEARCH. 7380 05:04:38,585 --> 05:04:41,121 TO GIVE BACKGROUND, I KNOW 7381 05:04:41,121 --> 05:04:42,656 YOU'VE HEARD ABOUT THIS 7382 05:04:42,656 --> 05:04:44,190 PREVIOUSLY, THE OFFICE OF 7383 05:04:44,190 --> 05:04:47,560 AUTOIMMUNE DISEASE RESEARCH WAS 7384 05:04:47,560 --> 05:04:49,663 ESTABLISHED LAST YEAR, ALIGNED 7385 05:04:49,663 --> 05:04:52,165 WITH CONTENT FROM THIS REPORT 7386 05:04:52,165 --> 05:04:55,235 WRITTEN BY NASEM IN 2022, AND 7387 05:04:55,235 --> 05:04:57,637 REALLY FOCUSED ON TRYING TO 7388 05:04:57,637 --> 05:05:00,273 ENHANCE THE NIH APPROACH TO 7389 05:05:00,273 --> 05:05:02,142 RESEARCH ON AUTOIMMUNE DISEASE, 7390 05:05:02,142 --> 05:05:04,110 TASKED WITH SIX THINGS THAT THE 7391 05:05:04,110 --> 05:05:06,046 CONGRESS HAD ASKED US TO DO, AND 7392 05:05:06,046 --> 05:05:08,682 I'M GOING TO HIGHLIGHT THE ONES 7393 05:05:08,682 --> 05:05:10,884 THIS PARTICULAR INITIATIVE WILL 7394 05:05:10,884 --> 05:05:11,751 FOCUS ON, PARTICULARLY 7395 05:05:11,751 --> 05:05:13,386 IDENTIFYING EMERGING AREAS OF 7396 05:05:13,386 --> 05:05:15,255 INNOVATION AND OPPORTUNITIES TO 7397 05:05:15,255 --> 05:05:17,157 SUPPORT RESEARCH, COORDINATING 7398 05:05:17,157 --> 05:05:18,425 AND FOSTERING COLLABORATEDDIVE 7399 05:05:18,425 --> 05:05:20,093 RESEARCH APPROACHES ACROSS THE 7400 05:05:20,093 --> 05:05:23,596 I.C.s, PROVIDING RESOURCES TO 7401 05:05:23,596 --> 05:05:28,101 SUPPORT PLANNING, COLLABORATION, 7402 05:05:28,101 --> 05:05:35,408 INNOVATION, AND THE SIXTH TO 7403 05:05:35,408 --> 05:05:36,176 DEVELOP PUBLICLY ACCESSIBLE 7404 05:05:36,176 --> 05:05:37,744 REPOSITORY, YOU CAN'T DO THAT 7405 05:05:37,744 --> 05:05:41,548 WITHOUT APPROACHING FROM A DATA 7406 05:05:41,548 --> 05:05:42,082 STANDPOINT. 7407 05:05:42,082 --> 05:05:44,417 SO, JUST TO SUMMARIZE AGAIN THIS 7408 05:05:44,417 --> 05:05:47,053 IS A REQUEST FOR THE COMMITTEE 7409 05:05:47,053 --> 05:05:50,223 TO VOTE ON A POTENTIAL NOTICE OF 7410 05:05:50,223 --> 05:05:52,192 SPECIAL INTEREST TO SUPPORT 7411 05:05:52,192 --> 05:05:53,626 BUILDING CONSENSUS FOR 7412 05:05:53,626 --> 05:05:54,527 AUTOIMMUNE DISEASE-RELATED 7413 05:05:54,527 --> 05:05:57,230 COMMON DATA ELEMENTS. 7414 05:05:57,230 --> 05:05:58,732 AGAIN, WE WERE LOOKING FOR 7415 05:05:58,732 --> 05:06:02,569 AWARDS WITH PROJECT PERIOD OF 7416 05:06:02,569 --> 05:06:04,571 ONE YEAR, AND WE ANTICIPATE 7417 05:06:04,571 --> 05:06:06,539 IDENTIFYING AREAS OF FOCUS 7418 05:06:06,539 --> 05:06:08,842 THROUGH OBVIOUSLY LITERATURE 7419 05:06:08,842 --> 05:06:10,043 REVIEW, INTERNAL, EXTERNAL 7420 05:06:10,043 --> 05:06:11,144 ENGAGEMENT, CONDUCTING A 7421 05:06:11,144 --> 05:06:13,980 PORTFOLIO ANALYSIS OF AUTOIMMUNE 7422 05:06:13,980 --> 05:06:15,181 DISEASE RESEARCH ACROSS NIH, 7423 05:06:15,181 --> 05:06:17,817 WE'RE EXPECTING WE WILL BE 7424 05:06:17,817 --> 05:06:20,987 SUPPORTIVE OF COLLABORATIVE 7425 05:06:20,987 --> 05:06:21,888 APPROACHES TO THIS CHALLENGE, 7426 05:06:21,888 --> 05:06:24,257 THERE'S BEEN A LOT OF I.C. 7427 05:06:24,257 --> 05:06:25,959 INTEREST IN SUPPORTING THIS AND 7428 05:06:25,959 --> 05:06:27,994 I'VE LISTED A FEW OF THE 7429 05:06:27,994 --> 05:06:32,432 PRIORITY DISEASE AREAS AS YOU 7430 05:06:32,432 --> 05:06:35,535 CAN SEE WITH 144 YOU CAN TAKE 7431 05:06:35,535 --> 05:06:37,604 YOUR PICK. 7432 05:06:37,604 --> 05:06:38,838 ONE LAST QR CODE IF YOU COULD 7433 05:06:38,838 --> 05:06:41,007 LIKE TO SIGN UP FOR OUR E-MAILS, 7434 05:06:41,007 --> 05:06:42,542 THIS WILL TAKE YOU TO THE E-MAIL 7435 05:06:42,542 --> 05:06:43,243 SIGN-UP. 7436 05:06:43,243 --> 05:06:46,613 WE HAVE A COUPLE SEMINARS THAT 7437 05:06:46,613 --> 05:06:51,851 THE AUDIENCE MIGHT BE INTERESTED 7438 05:06:51,851 --> 05:06:56,122 IN CLUES ONE ON XIST, AND 7439 05:06:56,122 --> 05:06:57,223 INCLUDING A SYMPOSIUM MAY 15. 7440 05:06:57,223 --> 05:06:58,625 THANK YOU FOR LISTENING. 7441 05:06:58,625 --> 05:07:08,701 I'LL BE HAPPY TO TAKE QUESTIONS. 7442 05:07:08,701 --> 05:07:09,702 >> A QUICK QUESTION. 7443 05:07:09,702 --> 05:07:12,872 WE LIKE TO FOCUS ON DISEASES. 7444 05:07:12,872 --> 05:07:15,408 WOULD IT BE WORTHWHILE TO FOCUS 7445 05:07:15,408 --> 05:07:16,810 ON PROCESSES, LONG ENCODING RNA 7446 05:07:16,810 --> 05:07:20,313 BASED ON EVERYTHING WE READ 7447 05:07:20,313 --> 05:07:20,747 RECENTLY? 7448 05:07:20,747 --> 05:07:21,181 >> YES. 7449 05:07:21,181 --> 05:07:22,382 WE'RE INTERESTED IN THAT 7450 05:07:22,382 --> 05:07:23,049 RESEARCH ALSO. 7451 05:07:23,049 --> 05:07:25,018 ONE OF THE AREAS THAT OUR OFFICE 7452 05:07:25,018 --> 05:07:26,986 IS INTERESTED IN LOOKING AT ARE 7453 05:07:26,986 --> 05:07:30,924 THINGS THAT CROSS BETWEEN 7454 05:07:30,924 --> 05:07:33,126 DIFFERENT ICO MISSION AREAS, AND 7455 05:07:33,126 --> 05:07:34,327 PERHAPS DON'T NECESSARILY FALL 7456 05:07:34,327 --> 05:07:36,096 INTO DISEASE AREAS, THAT LIST OF 7457 05:07:36,096 --> 05:07:37,630 DISEASES IS REALLY THE █LIST THT 7458 05:07:37,630 --> 05:07:43,369 WE'RE USING TO DO THIS INITIAL 7459 05:07:43,369 --> 05:07:52,212 PORTFOLIO ANALYSIS, , WHEN WE'RE 7460 05:07:52,212 --> 05:07:53,079 APPROACHING SUPPORTING 7461 05:07:53,079 --> 05:07:53,847 INFRASTRUCTURE FOR AUTOIMMUNE 7462 05:07:53,847 --> 05:07:55,815 DISEASE RESEARCH WE NEED TO 7463 05:07:55,815 --> 05:07:57,650 RECOGNIZE THE SCOPE OF WHAT 7464 05:07:57,650 --> 05:07:59,319 WE'RE BEING ASKED TO DO, AN 7465 05:07:59,319 --> 05:08:00,753 ENORMOUS LIFT. 7466 05:08:00,753 --> 05:08:03,556 >> MIGHT BE NICE TO EXPAND THE 7467 05:08:03,556 --> 05:08:04,991 SCOPE FROM THE PROCESS POINT OF 7468 05:08:04,991 --> 05:08:06,192 VIEW INCLUDING KEY PLAYERS, 7469 05:08:06,192 --> 05:08:09,262 EVERYBODY THINKS ABOUT IMMUNE 7470 05:08:09,262 --> 05:08:10,130 MECHANISMS, LONG ENCODING RNAs 7471 05:08:10,130 --> 05:08:12,332 LIKE EXIST IN OTHERS MAY BE 7472 05:08:12,332 --> 05:08:13,733 EXCITING. 7473 05:08:13,733 --> 05:08:14,000 >> YES. 7474 05:08:14,000 --> 05:08:15,502 WE'RE VERY EXCITED TOO, ALSO 7475 05:08:15,502 --> 05:08:17,904 OBVIOUSLY THE VARIOUS 7476 05:08:17,904 --> 05:08:19,439 ENVIRONMENTAL TRIGGERS, WE 7477 05:08:19,439 --> 05:08:22,809 TALKED ABOUT THE EXACT PLAN, 7478 05:08:22,809 --> 05:08:26,112 INAUGURAL AWARDS FROM OUR 7479 05:08:26,112 --> 05:08:27,413 OFFICE, TRYING TO INTEGRATE SOME 7480 05:08:27,413 --> 05:08:32,018 OF THIS DATA AND HOW DO YOU 7481 05:08:32,018 --> 05:08:34,754 UNDERSTAND INCLUDING AS WE 7482 05:08:34,754 --> 05:08:36,623 DESCRIBED ACROSS THE LIFESPAN, 7483 05:08:36,623 --> 05:08:38,591 TRANSITIONS IN PEOPLE'S BIOLOGIC 7484 05:08:38,591 --> 05:08:40,126 LIVES, WHEN DO THESE EXPOSURES 7485 05:08:40,126 --> 05:08:44,197 MATTER AND HOW DO THEY IMPACT 7486 05:08:44,197 --> 05:08:47,267 THE IMMUNE SYSTEM. 7487 05:08:47,267 --> 05:08:47,567 >> PLEASE. 7488 05:08:47,567 --> 05:08:48,902 >> I WANTED TO KNOW AS FAR AS 7489 05:08:48,902 --> 05:08:51,538 THE LIST OF CONDITIONS THAT ARE 7490 05:08:51,538 --> 05:08:53,606 HIGHLIGHTED, HOW DOES THAT LIST 7491 05:08:53,606 --> 05:08:56,142 REFLECT EITHER DISEASE BURDEN OR 7492 05:08:56,142 --> 05:08:57,143 MAYBE THE CURRENT PORTFOLIO 7493 05:08:57,143 --> 05:08:59,846 BEING FUNDED AND THOSE 7494 05:08:59,846 --> 05:09:01,814 CONDITIONS THAT MIGHT NOT HAVE A 7495 05:09:01,814 --> 05:09:04,651 LOT OF FUNDING CURRENTLY? 7496 05:09:04,651 --> 05:09:07,287 >> YEAH, SO WE OBVIOUSLY HAVE A 7497 05:09:07,287 --> 05:09:08,721 LARGE NUMBER OF DISEASES ON THE 7498 05:09:08,721 --> 05:09:09,255 LIST. 7499 05:09:09,255 --> 05:09:10,823 THE ONES I LISTED ON THE FINAL 7500 05:09:10,823 --> 05:09:12,992 SLIDE ARE JUST EXAMPLES. 7501 05:09:12,992 --> 05:09:16,262 SO, THIS WOULD BE SOMETHING THAT 7502 05:09:16,262 --> 05:09:20,133 WOULD BE AN OPEN COMPETITION FOR 7503 05:09:20,133 --> 05:09:23,503 APPLICATIONS, AND WE WOULD BE 7504 05:09:23,503 --> 05:09:27,340 SUPPORTIVE OF ANYTHING THAT'S 7505 05:09:27,340 --> 05:09:29,375 WELL REVIEWED. 7506 05:09:29,375 --> 05:09:35,748 >> OTHER QUESTIONS? 7507 05:09:35,748 --> 05:09:38,851 ANY QUESTIONS ON THE LINE? 7508 05:09:38,851 --> 05:09:39,052 OKAY. 7509 05:09:39,052 --> 05:09:41,688 AT THIS TIME WE'LL TAKE A VOTE 7510 05:09:41,688 --> 05:09:45,124 TO APPROVE THE NIH OFFICE OF 7511 05:09:45,124 --> 05:09:46,492 AUTOIMMUNE DISEASE RESEARCH 7512 05:09:46,492 --> 05:09:47,360 NOTICE OF SPECIAL INTEREST 7513 05:09:47,360 --> 05:09:48,194 CONCEPT CLEARANCE. 7514 05:09:48,194 --> 05:09:49,329 PLEASE NOTE THAT ONLY FULL 7515 05:09:49,329 --> 05:09:50,797 MEMBERS OF THE ADVISORY 7516 05:09:50,797 --> 05:09:52,265 COMMITTEE MAY VOTE. 7517 05:09:52,265 --> 05:09:54,267 AND IF YOU'RE AN AD HOC MEMBER, 7518 05:09:54,267 --> 05:10:00,173 OTHERWISE NOT A MEMBER OF ACRWH, 7519 05:10:00,173 --> 05:10:00,840 RESIST VOTING. 7520 05:10:00,840 --> 05:10:04,077 IS THERE A MOTION ON THE TABLE 7521 05:10:04,077 --> 05:10:09,816 TO APPROVE THE NOTICE OF SPECIAL 7522 05:10:09,816 --> 05:10:10,450 INTEREST? 7523 05:10:10,450 --> 05:10:10,783 >> SO MOVED. 7524 05:10:10,783 --> 05:10:12,418 >> DO I HAVE A SECOND? 7525 05:10:12,418 --> 05:10:13,853 >> I SECOND. 7526 05:10:13,853 --> 05:10:16,256 >> THANK YOU VERY MUCH. 7527 05:10:16,256 --> 05:10:18,324 SO ALL THOSE IN FAVOR OF 7528 05:10:18,324 --> 05:10:25,331 ACCEPTING THE MOTION PLEASE 7529 05:10:25,331 --> 05:10:27,166 RAISE YOUR HAND. 7530 05:10:27,166 --> 05:10:29,168 ALL THOSE OPPOSED TO THE MOTION 7531 05:10:29,168 --> 05:10:32,772 PLEASE RAISE YOUR HANDS NOW. 7532 05:10:32,772 --> 05:10:34,407 ALL THOSE ABSTAINING FROM THE 7533 05:10:34,407 --> 05:10:37,043 MOTION PLEASE NOW RAISE YOUR 7534 05:10:37,043 --> 05:10:39,612 HAND. 7535 05:10:39,612 --> 05:10:46,252 7536 05:10:46,252 --> 05:10:47,920 >> HAVE THE VOTES BEEN RECORDED? 7537 05:10:47,920 --> 05:10:48,721 >> YES, NINE IN FAVOR. 7538 05:10:48,721 --> 05:10:50,189 >> THANK YOU VERY MUCH. 7539 05:10:50,189 --> 05:10:52,158 THE NOTICE OF SPECIAL INTEREST 7540 05:10:52,158 --> 05:10:53,559 CONCEPT CLEARANCE HAS BEEN 7541 05:10:53,559 --> 05:10:55,128 ACCEPTED WITH NINE VOTES IN 7542 05:10:55,128 --> 05:10:56,996 FAVOR. 7543 05:10:56,996 --> 05:10:59,799 >> THANK YOU VERY MUCH. 7544 05:10:59,799 --> 05:11:02,101 >> THANK YOU, EVERYONE. 7545 05:11:02,101 --> 05:11:07,140 WE HAVE NOW REACHED OUR OPEN 7546 05:11:07,140 --> 05:11:07,807 DISCUSSION SESSION. 7547 05:11:07,807 --> 05:11:09,575 I WANTED TO MAKE SURE WE HAD 7548 05:11:09,575 --> 05:11:10,743 TIME FOR ADVISORY COMMITTEE 7549 05:11:10,743 --> 05:11:12,278 MEMBERS TO ASK ANY QUESTIONS 7550 05:11:12,278 --> 05:11:13,513 THEY MIGHT HAVE. 7551 05:11:13,513 --> 05:11:15,348 OR MAKE ANY COMMENTS THEY MIGHT 7552 05:11:15,348 --> 05:11:17,984 LIKE TO HAVE. 7553 05:11:17,984 --> 05:11:20,086 I'M GOING TO START ONLINE AND 7554 05:11:20,086 --> 05:11:24,257 JUST PUT DR. SHARPES AND DR. 7555 05:11:24,257 --> 05:11:27,760 TEMPLETON ON THE SPOT IF THEY 7556 05:11:27,760 --> 05:11:29,062 HAVE COMMENTS OR QUESTIONS 7557 05:11:29,062 --> 05:11:32,799 DURING THE MEETING OR TOPICS OF 7558 05:11:32,799 --> 05:11:33,499 INTEREST? 7559 05:11:33,499 --> 05:11:33,666 KIM? 7560 05:11:33,666 --> 05:11:35,401 >> THIS HAS BEEN AN AMAZING 7561 05:11:35,401 --> 05:11:35,735 MEETING. 7562 05:11:35,735 --> 05:11:37,270 I DON'T REALLY HAVE ANY 7563 05:11:37,270 --> 05:11:38,805 QUESTIONS ABOUT TODAY BUT I 7564 05:11:38,805 --> 05:11:40,773 WANTED TO THANK YOU AND YOUR 7565 05:11:40,773 --> 05:11:42,642 STAFF FOR THE OPPORTUNITY TO 7566 05:11:42,642 --> 05:11:44,143 SERVE ON THIS ADVISORY COMMITTEE 7567 05:11:44,143 --> 05:11:45,912 AND I APPRECIATE THE OPPORTUNITY 7568 05:11:45,912 --> 05:11:47,313 TO WORK WITH THE OTHER MEMBERS 7569 05:11:47,313 --> 05:11:49,148 OF THE COMMITTEE AND I HOPE OUR 7570 05:11:49,148 --> 05:11:50,383 PATHS CROSS AGAIN IN THE FUTURE. 7571 05:11:50,383 --> 05:11:52,151 THANK YOU VERY MUCH FOR THE 7572 05:11:52,151 --> 05:11:55,088 GREAT FOUR YEARS. 7573 05:11:55,088 --> 05:11:57,323 >> THANK YOU, DR. TEMPLETON. 7574 05:11:57,323 --> 05:11:59,892 DR. SHARPES, ANY COMMENTS? 7575 05:11:59,892 --> 05:12:02,895 >> YES, I WANTED TO SAY, IT'S 7576 05:12:02,895 --> 05:12:05,398 BEEN SAID ALREADY, THE STRATEGIC 7577 05:12:05,398 --> 05:12:07,066 PLAN IS VERY WELL WRITTEN AND 7578 05:12:07,066 --> 05:12:08,801 I'M VERY PROUD TO HAVE 7579 05:12:08,801 --> 05:12:11,003 CONTRIBUTED TO IT, AND ALL OF 7580 05:12:11,003 --> 05:12:11,571 THE PRESENTATIONS WERE 7581 05:12:11,571 --> 05:12:12,271 OUTSTANDING TODAY. 7582 05:12:12,271 --> 05:12:14,807 I HAVE NO QUESTION. 7583 05:12:14,807 --> 05:12:15,608 >> THANK YOU, PHYLLIS. 7584 05:12:15,608 --> 05:12:19,112 LET'S GO TO THE ROOM. 7585 05:12:19,112 --> 05:12:20,446 DR. NOEL, I'LL PUT YOU ON THE 7586 05:12:20,446 --> 05:12:26,018 SPOT IN A MINUTE AFTER I ASK 7587 05:12:26,018 --> 05:12:28,221 ABOUT THE QUESTION WITH THE HAND 7588 05:12:28,221 --> 05:12:29,055 RAISED. 7589 05:12:29,055 --> 05:12:30,289 >> THANK YOU. 7590 05:12:30,289 --> 05:12:33,025 REALLY EXCITING. 7591 05:12:33,025 --> 05:12:34,527 I'M FINISHING MY TERM ON THE 7592 05:12:34,527 --> 05:12:37,163 COUNCIL, THANK YOU VERY MUCH. 7593 05:12:37,163 --> 05:12:38,097 TERRIFIC. 7594 05:12:38,097 --> 05:12:41,667 ONE OF THE WAYS TO JUDGE A GOOD 7595 05:12:41,667 --> 05:12:42,368 INVOLVEMENT, GOOD ENGAGEMENT FOR 7596 05:12:42,368 --> 05:12:44,404 ME NOT HOW MUCH I CONTRIBUTE 7597 05:12:44,404 --> 05:12:45,471 ONLY BUT OF COURSE IT'S 7598 05:12:45,471 --> 05:12:47,340 IMPORTANT, HOW MUCH I LEARN. 7599 05:12:47,340 --> 05:12:50,109 I LEARN AT EVERY MEETING, SO 7600 05:12:50,109 --> 05:12:51,811 THANK YOU VERY, VERY MUCH. 7601 05:12:51,811 --> 05:12:53,946 ONE BRIEF COMMENT. 7602 05:12:53,946 --> 05:12:55,348 REALLY AN EXCITING DAY. 7603 05:12:55,348 --> 05:12:56,215 ALL THE INITIATIVES WE HEARD 7604 05:12:56,215 --> 05:12:57,950 ABOUT IN THE LAST WEEKS AND 7605 05:12:57,950 --> 05:13:01,020 MONTHS IN WOMEN'S HEALTH ARE 7606 05:13:01,020 --> 05:13:02,321 REALLY TERRIFIC, LONG TIME 7607 05:13:02,321 --> 05:13:04,891 WAITING BUT FINALLY COMING TO 7608 05:13:04,891 --> 05:13:05,158 FRUITION. 7609 05:13:05,158 --> 05:13:09,362 I MAY NOT OBSERVE IT ON COUNCIL 7610 05:13:09,362 --> 05:13:10,797 BUT FROM THE OUTSIDE. 7611 05:13:10,797 --> 05:13:12,231 WITH ALL THE EXCITEMENT, I WANT 7612 05:13:12,231 --> 05:13:14,100 TO MAKE SURE WE DON'T FORGET THE 7613 05:13:14,100 --> 05:13:15,835 OTHER THINGS WE'VE BEEN 7614 05:13:15,835 --> 05:13:18,237 DISCUSSING FOR SEVERAL YEARS, 7615 05:13:18,237 --> 05:13:21,974 FRONT AND STERILE ON STRATEGIC 7616 05:13:21,974 --> 05:13:25,912 PLAN -- FRONT AND CENTER ON 7617 05:13:25,912 --> 05:13:26,679 STRATEGIC PLANNING, INFANT 7618 05:13:26,679 --> 05:13:32,685 MATERNAL, MATERNAL HEALTH IN 7619 05:13:32,685 --> 05:13:34,887 PREGNANCY, ALL THE THINGS WITH 7620 05:13:34,887 --> 05:13:37,056 ARPA-H WE DON'T FORGET THOSE 7621 05:13:37,056 --> 05:13:37,523 ISSUES. 7622 05:13:37,523 --> 05:13:43,095 REPRESENTING COMMUNITY, MANY 7623 05:13:43,095 --> 05:13:44,530 PEOPLE ARE ASKING WHAT DO WE 7624 05:13:44,530 --> 05:13:47,934 NEED TO DO TO MAKE SURE KEY 7625 05:13:47,934 --> 05:13:49,335 THINGS WE'VE BEEN DISCUSSING 7626 05:13:49,335 --> 05:13:51,304 SADLY WENT UP DURING THE 7627 05:13:51,304 --> 05:13:53,072 PANDEMIC, THOSE ARE NOT LOST 7628 05:13:53,072 --> 05:13:54,373 WITH THE EXCITEMENT. 7629 05:13:54,373 --> 05:13:55,908 >> THANK YOU SO MUCH FOR YOUR 7630 05:13:55,908 --> 05:13:58,444 COMMENT AND YOUR SERVICE ON THE 7631 05:13:58,444 --> 05:13:58,978 ADVISORY COMMITTEE. 7632 05:13:58,978 --> 05:14:03,015 MA 7633 05:14:03,015 --> 05:14:03,883 MATERNAL HEALTH IS INTEGRAL, 7634 05:14:03,883 --> 05:14:07,854 WHEN YOU CONSIDER LIFE COURSE 7635 05:14:07,854 --> 05:14:10,790 PERSPECTIVE WE NEED TO MAKE SURE 7636 05:14:10,790 --> 05:14:14,060 IT'S PART OF WHAT WE'RE DOING. 7637 05:14:14,060 --> 05:14:15,528 WE CAN'T STOP THERE. 7638 05:14:15,528 --> 05:14:17,697 WE'RE BUILDING A BIGGER PIE. 7639 05:14:17,697 --> 05:14:20,333 WE WILL CARRY THAT WITH YOU AND 7640 05:14:20,333 --> 05:14:21,200 OUR COLLEAGUES AT THE EUNICE 7641 05:14:21,200 --> 05:14:22,869 KENNEDY SHRIVER INSTITUTE OF 7642 05:14:22,869 --> 05:14:23,836 CHILD HEALTH AND HUMAN 7643 05:14:23,836 --> 05:14:25,471 DEVELOPMENT ARE THE LEADERS IN 7644 05:14:25,471 --> 05:14:27,673 MATERNAL HEALTH BASE AND WE 7645 05:14:27,673 --> 05:14:31,844 ENJOY WORKING WITH THEM ON 7646 05:14:31,844 --> 05:14:37,950 IMPROV E. 7647 05:14:37,950 --> 05:14:40,486 THANK YOU FOR YOUR SERVICE. 7648 05:14:40,486 --> 05:14:42,421 >> INTERESTINGLY I HAD A RELATED 7649 05:14:42,421 --> 05:14:42,688 QUESTION. 7650 05:14:42,688 --> 05:14:45,091 I THOUGHT THIS SESSION WAS 7651 05:14:45,091 --> 05:14:47,159 GREAT, REALLY INFORMATIVE. 7652 05:14:47,159 --> 05:14:49,862 I THINK THE REPORTS WERE WELL 7653 05:14:49,862 --> 05:14:51,497 PRESENTED AND EVERYTHING. 7654 05:14:51,497 --> 05:14:53,266 SO, GOOD DAY IN GENERAL. 7655 05:14:53,266 --> 05:14:56,702 I HAD A QUESTION ALSO RELATED TO 7656 05:14:56,702 --> 05:14:58,871 INCREASED MATERNAL MORTALITY 7657 05:14:58,871 --> 05:14:59,438 THAT WE SEE WITHIN 7658 05:14:59,438 --> 05:15:01,607 UNDERREPRESENTED GROUPS. 7659 05:15:01,607 --> 05:15:03,042 NOW THAT THE INFORMATION IS OUT 7660 05:15:03,042 --> 05:15:07,747 THERE, THE NUMBERS ARE THERE TO 7661 05:15:07,747 --> 05:15:09,715 SUPPORT WHAT -- I DON'T WANT IN 7662 05:15:09,715 --> 05:15:11,150 YEARS TO STILL HAVE THE SAME 7663 05:15:11,150 --> 05:15:12,451 CONVERSATION WITH THE SAME 7664 05:15:12,451 --> 05:15:12,885 NUMBERS. 7665 05:15:12,885 --> 05:15:20,326 WHAT IS CURRENTLY BEING 7666 05:15:20,326 --> 05:15:28,534 IMPLEMENTED IN ORDER TO MODIFY 7667 05:15:28,534 --> 05:15:29,869 THE RISK UNDERREPRESENTED 7668 05:15:29,869 --> 05:15:31,837 COMMUNITIES COULD BE DONE WITH 7669 05:15:31,837 --> 05:15:32,605 GUIDELINES, PHYSICIANS ATTENDS 7670 05:15:32,605 --> 05:15:34,340 TO THE PATIENTS, OR SOMETHING 7671 05:15:34,340 --> 05:15:36,776 THAT NEEDS MORE RESEARCH, HOW 7672 05:15:36,776 --> 05:15:39,078 COULD WE GO FROM, FOR EXAMPLE, 7673 05:15:39,078 --> 05:15:41,681 THE SCIENCE TO REALLY THE 7674 05:15:41,681 --> 05:15:46,252 BEDSIDE AND BRING THE SCIENCE TO 7675 05:15:46,252 --> 05:15:46,719 THE PEOPLE? 7676 05:15:46,719 --> 05:15:48,988 >> THANK YOU FOR THOSE COMMENTS 7677 05:15:48,988 --> 05:15:49,989 AND QUESTION. 7678 05:15:49,989 --> 05:15:54,026 I DO THINK THE IMPLEMENTING THE 7679 05:15:54,026 --> 05:15:55,661 PREGNANCY OUTCOMES FOR EVERYONE, 7680 05:15:55,661 --> 05:15:56,796 THE "IMPROVE" INITIATIVE, DOES 7681 05:15:56,796 --> 05:15:59,065 ADDRESS HEALTH DISPARITIES AND 7682 05:15:59,065 --> 05:16:03,102 RACE AND ETHNICITY DATA THAT YOU 7683 05:16:03,102 --> 05:16:05,071 HAVE OUTLINED AND DR. 7684 05:16:05,071 --> 05:16:06,305 BERTAGNOLLI MENTIONED, THESE 7685 05:16:06,305 --> 05:16:06,939 DIFFERENTIAL RATES, BUT LOOKING 7686 05:16:06,939 --> 05:16:09,175 AT A VARIETY OF FACTORS, SOCIAL 7687 05:16:09,175 --> 05:16:10,676 DETERMINANTS OF HEALTH AND OTHER 7688 05:16:10,676 --> 05:16:13,713 STRUCTURAL FACTORS TO BE ABLE TO 7689 05:16:13,713 --> 05:16:15,481 ADDRESS THEM, IT MAY BE HELP 7690 05:16:15,481 --> 05:16:21,153 FOLLOW HAVE AN UPDATE ON IMPROVE 7691 05:16:21,153 --> 05:16:22,321 AT A FUTURE MEETING SO YOU CAN 7692 05:16:22,321 --> 05:16:24,557 SEE THE WORK AT THE CENTERS OF 7693 05:16:24,557 --> 05:16:25,891 EXCELLENCE NOW THAT SEVERAL ARE 7694 05:16:25,891 --> 05:16:29,695 FUNDED AS WELL AS WORK WE'RE 7695 05:16:29,695 --> 05:16:35,868 SUPPORTING WITH NIGM NIGMS AND 7696 05:16:35,868 --> 05:16:38,704 THE IDeA STATES. 7697 05:16:38,704 --> 05:16:41,207 I MENTIONED POSTPARTUM HEALTH 7698 05:16:41,207 --> 05:16:43,609 P2P, WE HAVE A SYSTEMATIC 7699 05:16:43,609 --> 05:16:48,781 EVIDENCE REVIEW, FEDERAL 7700 05:16:48,781 --> 05:16:51,183 PARTNERS AND INDEPENDENT PANEL, 7701 05:16:51,183 --> 05:16:53,152 LOOK THERE FOR POTENTIAL ACTION 7702 05:16:53,152 --> 05:16:54,020 SEVERAL FEDERAL AGENCIES TALKED 7703 05:16:54,020 --> 05:16:56,222 ABOUT TO ADDRESS THESE ISSUES. 7704 05:16:56,222 --> 05:16:58,090 MUCH MORE WORK TO BE DONE. 7705 05:16:58,090 --> 05:16:59,058 I KNOW INDIVIDUALS LIKE YOURSELF 7706 05:16:59,058 --> 05:17:01,594 AND OTHERS WILL KEEP OUR FEET TO 7707 05:17:01,594 --> 05:17:03,029 THE FIRE UNTIL WE CAN REALLY 7708 05:17:03,029 --> 05:17:05,197 MOVE THIS FORWARD ON A NATIONAL 7709 05:17:05,197 --> 05:17:06,432 LEVEL. 7710 05:17:06,432 --> 05:17:09,568 I APPRECIATE THE INPUT. 7711 05:17:09,568 --> 05:17:15,741 ANY OTHER QUESTIONS OR COMMENTS? 7712 05:17:15,741 --> 05:17:16,842 >> THIS GOES BACK TO THE 7713 05:17:16,842 --> 05:17:17,109 BEGINNING. 7714 05:17:17,109 --> 05:17:19,645 THANK YOU SO MUCH FOR YOUR 7715 05:17:19,645 --> 05:17:19,879 REPORT. 7716 05:17:19,879 --> 05:17:24,316 HE TALKED ABOUT ALCOHOLISM AND 7717 05:17:24,316 --> 05:17:26,318 RELATED DISEASES AND IT CAME UP 7718 05:17:26,318 --> 05:17:27,953 LATER DISCUSSING SMOKING AND HOW 7719 05:17:27,953 --> 05:17:30,056 THAT BEING A RISK FACTOR WE 7720 05:17:30,056 --> 05:17:34,627 FOCUSED ON. 7721 05:17:34,627 --> 05:17:37,930 WE HAVE SEEN CONDITIONS THAT 7722 05:17:37,930 --> 05:17:38,798 AFFECT WOMEN, ALCOHOL USE FLOATS 7723 05:17:38,798 --> 05:17:40,299 TO THE TOP. 7724 05:17:40,299 --> 05:17:45,237 ARE THERE PLANS FOR NIH OR ORWH 7725 05:17:45,237 --> 05:17:48,974 TO ELEVATE THAT IN THE RESEARCH 7726 05:17:48,974 --> 05:17:51,610 PLAN AND STUDYING AUTOIMMUNE OR 7727 05:17:51,610 --> 05:17:55,948 OUGHT CONDITIONS? 7728 05:17:55,948 --> 05:17:59,151 >> SO THE NIAAA HAS A FOCUS ON 7729 05:17:59,151 --> 05:18:01,120 SEX DIFFERENCES IN WOMEN, THEY 7730 05:18:01,120 --> 05:18:02,521 HAD WORKSHOPS ON ALCOHOLISM, NOW 7731 05:18:02,521 --> 05:18:05,591 A MODEL CONTINUUM OF CARE 7732 05:18:05,591 --> 05:18:06,258 INITIATIVE, SPECIFICALLY 7733 05:18:06,258 --> 05:18:07,226 ADDRESSING LIFE COURSE AND 7734 05:18:07,226 --> 05:18:12,164 HEALTH OF WOMEN WITH ALCOHOL 7735 05:18:12,164 --> 05:18:12,364 USE. 7736 05:18:12,364 --> 05:18:14,467 IT'S A PLANNING GRANT AT THIS 7737 05:18:14,467 --> 05:18:14,667 POINT. 7738 05:18:14,667 --> 05:18:17,436 I DO EXPECT TO SEE MORE COMING 7739 05:18:17,436 --> 05:18:18,437 OUT OF THAT. 7740 05:18:18,437 --> 05:18:21,474 IN THE MENTAL HEALTH SUBSTANCE 7741 05:18:21,474 --> 05:18:24,410 USE, ALL SUBSTANCES SPACE, NIDA 7742 05:18:24,410 --> 05:18:26,512 ALSO HAS A VERY CLEAR INTEREST 7743 05:18:26,512 --> 05:18:27,847 IN SEX DIFFERENCES. 7744 05:18:27,847 --> 05:18:30,583 AND THROUGH OUR SCORE WE HAVE 7745 05:18:30,583 --> 05:18:32,651 SEVERAL SCOREs IN THAT SPACE. 7746 05:18:32,651 --> 05:18:36,489 SO I WOULD SAY STAY TUNED FOR 7747 05:18:36,489 --> 05:18:38,090 THE MODEL CONTINUUM OF CARE 7748 05:18:38,090 --> 05:18:44,029 INITIATIVE AS THE NEXT NEW THING 7749 05:18:44,029 --> 05:18:46,866 AND NIAAA AND DR. KOOB HAVE BEEN 7750 05:18:46,866 --> 05:18:47,767 ACTIVE ELEVATING THESEI. 7751 05:18:47,767 --> 05:18:50,035 AS WE LAUNCH THE NEXT STRATEGIC 7752 05:18:50,035 --> 05:18:51,604 PLAN FOR WOMEN'S HEALTH RESEARCH 7753 05:18:51,604 --> 05:18:55,307 WE EXPECT TO BE COLLABORATING. 7754 05:18:55,307 --> 05:18:56,609 YOU HEARD FROM DR. BERTAGNOLLI 7755 05:18:56,609 --> 05:18:59,812 SHOW WANTS TO WORK ACROSS SILOS 7756 05:18:59,812 --> 05:19:02,848 AND ELIMINATE SILOS, NIMH, NIDA 7757 05:19:02,848 --> 05:19:05,151 AND NIAAA ARE ALL INTERESTED IN 7758 05:19:05,151 --> 05:19:06,352 THESE ISSUES. 7759 05:19:06,352 --> 05:19:09,522 SO WE'D LIKE TO CONTINUE TO 7760 05:19:09,522 --> 05:19:11,257 STIMULATE ATTENTION TO 7761 05:19:11,257 --> 05:19:12,158 SCIENTIFIC SYNERGIES THAT COULD 7762 05:19:12,158 --> 05:19:13,192 BE ADDRESSED BY LOOKING AT THE 7763 05:19:13,192 --> 05:19:16,028 HEALTH OF WOMEN AS A CENTRAL 7764 05:19:16,028 --> 05:19:17,096 POINT. 7765 05:19:17,096 --> 05:19:20,499 >> SO THIS IS ALSO MY LAST 7766 05:19:20,499 --> 05:19:20,833 MEETING. 7767 05:19:20,833 --> 05:19:22,067 MY ONLY IN-PERSON MEETING. 7768 05:19:22,067 --> 05:19:24,970 I STARTED MY TERM DURING THE 7769 05:19:24,970 --> 05:19:25,371 PANDEMIC. 7770 05:19:25,371 --> 05:19:27,173 AND I DON'T KNOW, I GOT USED 7771 05:19:27,173 --> 05:19:28,808 TO -- I WANT TO GIVE AN OVERVIEW 7772 05:19:28,808 --> 05:19:30,009 OF MY EXPERIENCE ON THIS 7773 05:19:30,009 --> 05:19:32,211 COMMITTEE, I GOT USED TO BEING 7774 05:19:32,211 --> 05:19:34,280 INSPIRED BY DR. CLAYTON. 7775 05:19:34,280 --> 05:19:36,348 THAT BECAME -- I EXPECTED THAT. 7776 05:19:36,348 --> 05:19:37,883 I DON'T KNOW, TODAY REALLY TOOK 7777 05:19:37,883 --> 05:19:39,752 THE CAKE THOUGH. 7778 05:19:39,752 --> 05:19:42,688 I MEAN, EVERY SINGLE TALK WAS 7779 05:19:42,688 --> 05:19:45,224 INSPIRING, TO HEAR A WOMAN AS 7780 05:19:45,224 --> 05:19:46,392 THE NIH DIRECTOR, SOMEONE I'VE 7781 05:19:46,392 --> 05:19:48,160 KNOWN FOR A LONG TIME AND 7782 05:19:48,160 --> 05:19:53,299 RESPECT IN THE FIELD OF 7783 05:19:53,299 --> 05:19:54,934 ONCOLOGY, SPEAK SO COMPELLINGLY 7784 05:19:54,934 --> 05:19:56,602 ABOUT HOW IT'S NOT ENOUGH JUST 7785 05:19:56,602 --> 05:19:58,137 TO MAKE THE DISCOVERIES, WE HAVE 7786 05:19:58,137 --> 05:20:00,506 TO SEE IT TRANSLATE INTO 7787 05:20:00,506 --> 05:20:01,340 IMPROVED HEALTH. 7788 05:20:01,340 --> 05:20:04,276 I'M SO INVIGORATED TO SEE OUR 7789 05:20:04,276 --> 05:20:06,011 POLITICAL SYSTEM, PRIORITIZING 7790 05:20:06,011 --> 05:20:09,415 THE HEALTH OF WOMEN, TO HEAR THE 7791 05:20:09,415 --> 05:20:10,950 AMAZING PANELIST, IT'S VERY RARE 7792 05:20:10,950 --> 05:20:12,751 THAT I RETHINK MY LIFE CHOICES. 7793 05:20:12,751 --> 05:20:18,624 I DON'T WANT TO DO YOUR 7794 05:20:18,624 --> 05:20:19,425 RESEARCH. 7795 05:20:19,425 --> 05:20:21,126 IT'S SO FASCINATING, SO 7796 05:20:21,126 --> 05:20:22,862 INSPIRED, THE TIME WAS OVER TOO 7797 05:20:22,862 --> 05:20:23,195 FAST. 7798 05:20:23,195 --> 05:20:24,763 THANK YOU FOR LETTING ME DO 7799 05:20:24,763 --> 05:20:24,964 THIS. 7800 05:20:24,964 --> 05:20:25,865 >> THANK YOU. 7801 05:20:25,865 --> 05:20:27,299 YOU'VE BEEN A GREAT COMMITTEE 7802 05:20:27,299 --> 05:20:28,968 MEMBER AND I CAN'T BELIEVE THIS 7803 05:20:28,968 --> 05:20:30,636 IS THE FIRST IN-PERSON MEETING. 7804 05:20:30,636 --> 05:20:33,606 FEELS LIKE WE'VE BEEN DOING THIS 7805 05:20:33,606 --> 05:20:36,976 IN PERSON, YOU KNOW, WE 7806 05:20:36,976 --> 05:20:37,977 APPRECIATE THE KIND WORDS. 7807 05:20:37,977 --> 05:20:40,813 AND I AGREE WITH YOU, THE 7808 05:20:40,813 --> 05:20:44,083 SPEAKERS AND TOPIC IS CRITICAL. 7809 05:20:44,083 --> 05:20:47,052 IT'S INSPIRING TO SEE OTHER 7810 05:20:47,052 --> 05:20:48,120 PEOPLE RECOGNIZING HOW IMPORTANT 7811 05:20:48,120 --> 05:20:52,157 IT IS TO THE HEALTH OF THE 7812 05:20:52,157 --> 05:20:52,391 NATION. 7813 05:20:52,391 --> 05:20:54,860 SO FOR THAT I'M GRATEFUL. 7814 05:20:54,860 --> 05:20:55,194 DR. HIGGINS? 7815 05:20:55,194 --> 05:20:59,732 >> I WANT TO BUILD ON THAT 7816 05:20:59,732 --> 05:21:00,699 SINCERELY. 7817 05:21:00,699 --> 05:21:04,003 THIS IS ALMOST THROUGH MY 38th 7818 05:21:04,003 --> 05:21:05,537 YEAR OF NIH RESEARCH, AND 7819 05:21:05,537 --> 05:21:06,305 MEETINGS LIKE THIS. 7820 05:21:06,305 --> 05:21:09,041 I DON'T THINK I'VE EVER BEEN AT 7821 05:21:09,041 --> 05:21:11,110 A ONE-DAY MEETING THAT WAS 7822 05:21:11,110 --> 05:21:14,113 BETTER THAN THIS ONE, THE 7823 05:21:14,113 --> 05:21:16,749 QUALITY WAS JUST AMAZING. 7824 05:21:16,749 --> 05:21:18,918 I JUST FELT LIKE I WAS SO LUCKY 7825 05:21:18,918 --> 05:21:22,821 TO SIT HERE LISTENING TO THE 7826 05:21:22,821 --> 05:21:23,355 PRESENTATIONS, AND WITHOUT 7827 05:21:23,355 --> 05:21:25,124 EXCEPTION, SO GREAT JOB ON THIS. 7828 05:21:25,124 --> 05:21:30,162 AND HOPEFULLY I GET TO COME TO A 7829 05:21:30,162 --> 05:21:31,363 COUPLE MORE IN-PERSON MEETINGS. 7830 05:21:31,363 --> 05:21:32,665 >> THANK YOU. 7831 05:21:32,665 --> 05:21:33,332 DR. ANDERSON? 7832 05:21:33,332 --> 05:21:34,967 >> YEAH, IT'S BEEN A GREAT 7833 05:21:34,967 --> 05:21:35,334 MEETING. 7834 05:21:35,334 --> 05:21:37,069 I WANTED TO PUT A COUPLE OTHER 7835 05:21:37,069 --> 05:21:45,477 TOPICS ON TO MAKE SURE THAT WE 7836 05:21:45,477 --> 05:21:52,351 PAY ATTENTION, HEALTH OF 7837 05:21:52,351 --> 05:21:53,118 ADOLESCENTS, MENARCHE AND 7838 05:21:53,118 --> 05:21:54,720 OTHERS, THESE YOUNG WOMEN ARE 7839 05:21:54,720 --> 05:21:55,754 SUFFERING. 7840 05:21:55,754 --> 05:21:59,358 ON THE OTHER EXTREME, OUR AGING 7841 05:21:59,358 --> 05:22:00,793 WOMEN, AND THINKING ABOUT 7842 05:22:00,793 --> 05:22:02,661 CAREGIVING, ESPECIALLY. 7843 05:22:02,661 --> 05:22:04,196 THE BURDENS OF CAREGIVING AND 7844 05:22:04,196 --> 05:22:06,999 ITS IMPACT ON THEIR HEALTH IS 7845 05:22:06,999 --> 05:22:08,467 REALLY IMPORTANT AND SO I'D LIKE 7846 05:22:08,467 --> 05:22:14,707 TO MAKES SURE THAT'S ADDRESSED. 7847 05:22:14,707 --> 05:22:15,074 >> THANKS. 7848 05:22:15,074 --> 05:22:16,809 MUSCULOSKELETAL ISSUES HAVE BEEN 7849 05:22:16,809 --> 05:22:18,210 MENTIONED AT BOTH ENDS OF THE 7850 05:22:18,210 --> 05:22:23,148 EXTREME AS CRITICALLY IMPORTANT. 7851 05:22:23,148 --> 05:22:24,183 OTHER COMMENTS? 7852 05:22:24,183 --> 05:22:26,952 >> I WON'T BE THE ONLY ONE WHO 7853 05:22:26,952 --> 05:22:29,054 DOESN'T COMMENT, I'LL DITTO WHAT 7854 05:22:29,054 --> 05:22:30,022 EVERYONE SAID. 7855 05:22:30,022 --> 05:22:31,657 IT'S BEEN A MAGNIFICENT DAY. 7856 05:22:31,657 --> 05:22:33,659 THANK YOU. 7857 05:22:33,659 --> 05:22:35,294 ALSO JUST TO REINFORCE LOOKING 7858 05:22:35,294 --> 05:22:37,262 AT CAREGIVERS AND THEIR HEALTH, 7859 05:22:37,262 --> 05:22:38,797 SINCE THE MAJORITY OF CAREGIVERS 7860 05:22:38,797 --> 05:22:39,765 ARE WOMEN, YOU'VE HEARD THAT 7861 05:22:39,765 --> 05:22:40,332 BEFORE. 7862 05:22:40,332 --> 05:22:43,402 IT WOULD BE NICE TO SEE SOME 7863 05:22:43,402 --> 05:22:46,472 ACTION IN THAT MOVING FORWARD. 7864 05:22:46,472 --> 05:22:49,408 >> I THOUGHT YOU WERE GOING TO 7865 05:22:49,408 --> 05:22:51,043 MENTION PHYSICAL ACTIVITY, 7866 05:22:51,043 --> 05:22:52,578 ANOTHER IMPORTANT TOPIC. 7867 05:22:52,578 --> 05:22:52,911 ALEXANDER? 7868 05:22:52,911 --> 05:22:56,515 >> I WANTED TO ASK, YOU DIDN'T 7869 05:22:56,515 --> 05:22:58,817 TOUCH ON IT BUT FOR SEX AS A 7870 05:22:58,817 --> 05:23:02,421 BIOLOGICAL VARIABLE, IN GRANTS, 7871 05:23:02,421 --> 05:23:03,889 RESEARCHERS HAVE TO PUT BOTH, 7872 05:23:03,889 --> 05:23:05,958 BUT WHEN IT'S REPORTED IN 7873 05:23:05,958 --> 05:23:07,426 LITERATURE IF THEY DIDN'T SEE 7874 05:23:07,426 --> 05:23:08,894 MAJOR SEX DIFFERENCE THEY WILL 7875 05:23:08,894 --> 05:23:11,964 PULL THE DATA OF MEN AND WOMEN 7876 05:23:11,964 --> 05:23:12,431 TOGETHER. 7877 05:23:12,431 --> 05:23:13,932 IS IT POSSIBLE TO MENTION 7878 05:23:13,932 --> 05:23:16,769 SOMEWHERE THAT IT HAS TO BE 7879 05:23:16,769 --> 05:23:18,404 DEAGGREGATED DATA FOR MALE AND 7880 05:23:18,404 --> 05:23:20,105 FEMALE ONCE IT GETS TO 7881 05:23:20,105 --> 05:23:20,406 PUBLICATION? 7882 05:23:20,406 --> 05:23:21,807 I THINK AS SCIENTISTS WE MAY BE 7883 05:23:21,807 --> 05:23:23,008 MISSING A LOT. 7884 05:23:23,008 --> 05:23:26,412 I'M TALKING ABOUT BASIC SCIENCE 7885 05:23:26,412 --> 05:23:28,147 HERE, I'M SURE HUMAN DATA IS 7886 05:23:28,147 --> 05:23:29,782 PROBABLY MEN AND WOMEN BUT I 7887 05:23:29,782 --> 05:23:31,750 KNOW WHEN IT COMES TO ANIMAL 7888 05:23:31,750 --> 05:23:33,285 MODELS, SOMETIMES THE DATA COULD 7889 05:23:33,285 --> 05:23:35,054 BE AGGREGATED FOR BOTH SEXES AND 7890 05:23:35,054 --> 05:23:37,222 I THINK WE'RE MISSING SOMETHING 7891 05:23:37,222 --> 05:23:37,990 THERE. 7892 05:23:37,990 --> 05:23:41,860 >> THANK YOU FOR BRINGING UP 7893 05:23:41,860 --> 05:23:42,728 SABV, DR. NOEL. 7894 05:23:42,728 --> 05:23:45,264 WE'LL TALK ABOUT THE GOOD NEWS, 7895 05:23:45,264 --> 05:23:46,932 ON THE CLINICAL SIDE, YOU'RE A 7896 05:23:46,932 --> 05:23:49,868 BASIC SCIENTIST, BUT ON THE 7897 05:23:49,868 --> 05:23:51,970 CLINICAL SIDE WE HAVE SEEN AN 7898 05:23:51,970 --> 05:23:56,542 INCREASE IN REPORTING OF SEX 7899 05:23:56,542 --> 05:23:57,543 DISAGGREGATED RESULTS FOR PHASE 7900 05:23:57,543 --> 05:24:01,814 3 CLINICAL TRIALS GOING FROM 27, 7901 05:24:01,814 --> 05:24:08,921 29% FIVE OR TEN YEARS AGO TO 7902 05:24:08,921 --> 05:24:14,726 43%, SUBSTANTIAL INCREASE, . 7903 05:24:14,726 --> 05:24:17,496 GUIDELINES HAVE BEEN ADOPTED FOR 7904 05:24:17,496 --> 05:24:21,333 MANY JOURNALS, THE ICMJE ADOPTED 7905 05:24:21,333 --> 05:24:22,901 GUIDELINES AS WELL AS 7906 05:24:22,901 --> 05:24:25,370 ENCOURAGING THEM BUT IT IS 7907 05:24:25,370 --> 05:24:26,138 HIGHLY VARIABLE ACROSS 7908 05:24:26,138 --> 05:24:28,640 DISCIPLINES AND FIELDS ON THE 7909 05:24:28,640 --> 05:24:31,743 BASIC SCIENCE AND PRE-CLINICAL 7910 05:24:31,743 --> 05:24:32,811 RESEARCH SIDE. 7911 05:24:32,811 --> 05:24:35,347 THE POLICY WE DO NOT CONTROL 7912 05:24:35,347 --> 05:24:37,216 JOURNAL EDITORS AND THEIR 7913 05:24:37,216 --> 05:24:38,851 EDITORIAL POLICIES. 7914 05:24:38,851 --> 05:24:40,352 HOWEVER, WE ARE WORKING ON WAYS 7915 05:24:40,352 --> 05:24:42,654 TO WORK WITH JOURNAL EDITORS AND 7916 05:24:42,654 --> 05:24:43,255 PUBLISHERS TO CONTINUE TO 7917 05:24:43,255 --> 05:24:44,623 DEMONSTRATE HOW IMPORTANT IT IS 7918 05:24:44,623 --> 05:24:46,492 TO DO SO. 7919 05:24:46,492 --> 05:24:49,995 AS YOU SAID, TO DERIVE 7920 05:24:49,995 --> 05:24:50,996 SCIENTIFIC INSIGHTS AND TO 7921 05:24:50,996 --> 05:24:53,365 MAXIMIZE WHAT YOU LEARN FROM 7922 05:24:53,365 --> 05:24:54,800 EVERY EXPERIMENT IN EVERY STUDY. 7923 05:24:54,800 --> 05:24:57,436 KEEP ASKING US ABOUT THAT. 7924 05:24:57,436 --> 05:24:58,670 WE'RE DOING SOME INTERNAL STEPS 7925 05:24:58,670 --> 05:25:00,539 AND HOPEFULLY I'LL BE ABLE TO 7926 05:25:00,539 --> 05:25:06,011 SHARE MORE WITH YOU AT THE NEXT 7927 05:25:06,011 --> 05:25:06,245 MEETING. 7928 05:25:06,245 --> 05:25:06,445 IRENE? 7929 05:25:06,445 --> 05:25:10,149 >> I DID WANT TO ACTUALLY 7930 05:25:10,149 --> 05:25:12,518 DOVETAIL ON BIT TO COMMEND ORWH. 7931 05:25:12,518 --> 05:25:14,653 YOU BROUGHT UP SABV. 7932 05:25:14,653 --> 05:25:17,289 IT'S AN OLD TOPIC PER SE BUT THE 7933 05:25:17,289 --> 05:25:20,025 FACT THAT YOU HAVE STUCK WITH 7934 05:25:20,025 --> 05:25:22,294 ENGAGING FORMER WINS TO MAKE 7935 05:25:22,294 --> 05:25:24,530 SURE THEY DON'T FALL OFF AS WE 7936 05:25:24,530 --> 05:25:24,930 PROGRESS THROUGH. 7937 05:25:24,930 --> 05:25:26,598 IT'S A LOT BECAUSE YOU KEEP 7938 05:25:26,598 --> 05:25:29,635 ADDING MORE AND MORE WORK TO THE 7939 05:25:29,635 --> 05:25:32,070 PLATE BUT I REALLY COMMEND ORWH 7940 05:25:32,070 --> 05:25:33,372 FOR STICKING WITH TOPICS OVER 7941 05:25:33,372 --> 05:25:34,907 THE YEARS AND HAVING THAT IMPACT 7942 05:25:34,907 --> 05:25:36,341 AND MAKING SURE THAT YOU DON'T 7943 05:25:36,341 --> 05:25:37,876 ALLOW IT TO FALL TO THE WAYSIDE 7944 05:25:37,876 --> 05:25:41,046 AS YOU TAKE ON MORE WORK. 7945 05:25:41,046 --> 05:25:43,982 >> THANK YOU SO MUCH, IRENE. 7946 05:25:43,982 --> 05:25:47,052 LAST COMMENTS BEFORE WE ADJOURN? 7947 05:25:47,052 --> 05:25:50,455 I DO WANT TO THANK ALL OF THE 7948 05:25:50,455 --> 05:25:51,890 AMAZING -- OOPS, WAIT, WAIT, 7949 05:25:51,890 --> 05:25:52,191 WAIT. 7950 05:25:52,191 --> 05:25:54,726 WHO IS ONLINE, IS THAT DR. SIMON 7951 05:25:54,726 --> 05:25:56,161 IN A CAB? 7952 05:25:56,161 --> 05:25:57,996 OKAY, DR. SIMON, I SEE YOU. 7953 05:25:57,996 --> 05:25:58,864 GO RIGHT AHEAD. 7954 05:25:58,864 --> 05:26:00,332 >> I'M NOT IN A CAB NOW. 7955 05:26:00,332 --> 05:26:01,667 I JUST GOT OUT. 7956 05:26:01,667 --> 05:26:02,935 I'M IN THE AIRPORT. 7957 05:26:02,935 --> 05:26:05,370 AGAIN, THANK YOU. 7958 05:26:05,370 --> 05:26:08,073 I ECHO EVERYONE'S POSITIVE 7959 05:26:08,073 --> 05:26:08,840 COMMENTS, AMAZING MEETING. 7960 05:26:08,840 --> 05:26:12,144 I JUST WANT TO KNOW IF MAYBE 7961 05:26:12,144 --> 05:26:15,447 NEXT TIME OR THE FOLLOWING TIME 7962 05:26:15,447 --> 05:26:18,417 AS WE -- AS YOU ALL PUT OUT MORE 7963 05:26:18,417 --> 05:26:20,686 OF THESE SPECIFIC REQUESTS FOR 7964 05:26:20,686 --> 05:26:23,855 PROPOSALS, NOW YOU HAVE THE 7965 05:26:23,855 --> 05:26:28,260 NOSI, THAT'S ACROSS ANY, ARE WE 7966 05:26:28,260 --> 05:26:30,862 -- NIH, ARE WE GOING TO LOOK AT 7967 05:26:30,862 --> 05:26:34,499 DATA, WHO GETS FUNDED, ARE THEY 7968 05:26:34,499 --> 05:26:35,467 EARLY CAREER INVESTIGATORS, KIND 7969 05:26:35,467 --> 05:26:39,304 OF LIKE AN OVERVIEW TO GET A 7970 05:26:39,304 --> 05:26:41,173 SENSE OF WHAT KIND OF RESEARCH 7971 05:26:41,173 --> 05:26:43,475 IS BEING FUNDED UNDER SPECIFIC 7972 05:26:43,475 --> 05:26:46,311 RFAs, ALSO FOR THE NOSI WHAT 7973 05:26:46,311 --> 05:26:49,815 KINDS OF RESEARCH IS BEING 7974 05:26:49,815 --> 05:26:50,048 FUNDED. 7975 05:26:50,048 --> 05:26:53,018 JUST HOPE WE CAN SEE HOW WE'RE 7976 05:26:53,018 --> 05:26:53,252 DOING. 7977 05:26:53,252 --> 05:26:55,621 >> THANK YOU, DR. SIMON. 7978 05:26:55,621 --> 05:26:56,655 ABSOLUTELY UNDERSTAND THAT YOU 7979 05:26:56,655 --> 05:27:00,559 WANT TO BETTER BE ABLE TO 7980 05:27:00,559 --> 05:27:01,426 CHARACTERIZEED INVESTIGATORS AND 7981 05:27:01,426 --> 05:27:03,395 APPLICANTS FOR WOMEN'S HEALTH 7982 05:27:03,395 --> 05:27:06,465 RELEVANT FUNDING OPPORTUNITIES 7983 05:27:06,465 --> 05:27:08,767 ACROSS NIH, AN EXCITING WITH THE 7984 05:27:08,767 --> 05:27:09,635 OPPORTUNITY WITH THE NOSI 7985 05:27:09,635 --> 05:27:10,502 THERE'S MORE DATA. 7986 05:27:10,502 --> 05:27:12,471 AN IMPORTANT THING TO LOOK AT 7987 05:27:12,471 --> 05:27:14,339 ESPECIALLY LOOKING AT EARLY 7988 05:27:14,339 --> 05:27:16,441 DECISION INVESTIGATORS, NEW 7989 05:27:16,441 --> 05:27:17,075 INVESTIGATORS, AND JUST 7990 05:27:17,075 --> 05:27:20,479 CHARACTERIZING DEMOGRAPHICS OF 7991 05:27:20,479 --> 05:27:22,214 THAT INVESTIGATOR POOL. 7992 05:27:22,214 --> 05:27:23,415 >> AND THE TOPICS. 7993 05:27:23,415 --> 05:27:23,949 >> AND TOPICS. 7994 05:27:23,949 --> 05:27:25,617 HAPPY TO LOOK INTO THAT. 7995 05:27:25,617 --> 05:27:28,420 >> THANK YOU. 7996 05:27:28,420 --> 05:27:29,221 >> ANYTHING ELSE? 7997 05:27:29,221 --> 05:27:31,323 >> DR. JONES HAD TO LEAVE EARLY 7998 05:27:31,323 --> 05:27:34,359 TO MAKE SURE SHE'S NOT ONLINE 7999 05:27:34,359 --> 05:27:34,593 THERE. 8000 05:27:34,593 --> 05:27:36,128 WITH THAT, AGAIN, I WANT TO TAKE 8001 05:27:36,128 --> 05:27:38,330 ALL THE SPEAKERS, ALL THE 8002 05:27:38,330 --> 05:27:40,499 PRESENTERS, ALL OF THE ADVISORY 8003 05:27:40,499 --> 05:27:42,267 COMMITTEE MEMBERS FOR YOUR 8004 05:27:42,267 --> 05:27:44,870 INCREDIBLE WORK FOR ORWH AND FOR 8005 05:27:44,870 --> 05:27:46,405 WOMEN'S HEALTH RESEARCH. 8006 05:27:46,405 --> 05:27:51,643 I WANT TO ACKNOWLEDGE DR. OTA 8007 05:27:51,643 --> 05:27:53,478 WANG, EXEC SEC AND INCREDIBLE 8008 05:27:53,478 --> 05:27:55,280 TEAM OF FOLKS BEHIND THE SCENES, 8009 05:27:55,280 --> 05:27:56,381 BEHIND THE CURTAIN, WHO MADE 8010 05:27:56,381 --> 05:27:57,783 SURE YOU WERE HERE, WHO MADE 8011 05:27:57,783 --> 05:28:00,185 SURE THE SLIDES WERE HERE, ALL 8012 05:28:00,185 --> 05:28:02,487 OF OUR FEDERAL EMPLOYEES, 8013 05:28:02,487 --> 05:28:04,256 COMMUNICATIONS TEAM, LOGISTICAL 8014 05:28:04,256 --> 05:28:05,557 SUPPORT TEAM, CONTRACTORS, 8015 05:28:05,557 --> 05:28:10,062 EVERYONE WHO SUPPORTED TODAY. 8016 05:28:10,062 --> 05:28:14,666 THANK YOU VERY MUCH. 8017 05:28:14,666 --> 05:28:16,168 INCLUDING THE COMS TEAM WHO GETS 8018 05:28:16,168 --> 05:28:19,271 THE WORD OUT. 8019 05:28:19,271 --> 05:28:20,038 SAFE TRAVELS HOME. 8020 05:28:20,038 --> 05:28:22,874 WE'LL SEE ON YOU OCTOBER 16 FOR 8021 05:28:22,874 --> 05:28:24,309 THE 61st MEETING, WE'RE NOW 8022 05:28:24,309 --> 05:28:24,710 ADJOURNED. 8023 05:28:24,710 --> 05:28:25,243 THANK YOU VERY MUCH. 8024 05:28:25,243 --> 05:28:27,813 [END OF PROGRAM] 8025 05:28:27,813 --> 05:28:37,856