1 00:00:07,674 --> 00:00:10,343 >> WELCOME TO THE FEBRUARY 6, 2 00:00:10,410 --> 00:00:11,010 2024 MEETING OF THE NATIONAL 3 00:00:11,077 --> 00:00:13,279 LIBRARY OF MEDICINE BOARD OF 4 00:00:13,346 --> 00:00:14,013 REGENTS. 5 00:00:14,080 --> 00:00:15,148 IT'S WONDERFUL TO SEE EVERYONE, 6 00:00:15,215 --> 00:00:18,051 A PLEASURE TO CALL THE MEETING 7 00:00:18,118 --> 00:00:20,019 TO ORDER. 8 00:00:20,086 --> 00:00:21,421 AS A REMINDER, THIS MEETING IS 9 00:00:21,488 --> 00:00:23,623 BEING VIDEOCAST TO THE PUBLIC. 10 00:00:23,690 --> 00:00:24,824 BEFORE WE GET STARTED, I'D LIKE 11 00:00:24,891 --> 00:00:29,329 TO EXTEND A WARM WELCOME TO THE 12 00:00:29,396 --> 00:00:30,563 CHIEF OF MEDICAL OPERATIONS, 13 00:00:30,630 --> 00:00:33,299 OFFICE OF THE AIR FORCE SURGEON 14 00:00:33,366 --> 00:00:34,167 GENERAL, ATTENDING FOR THE 15 00:00:34,234 --> 00:00:40,206 SURGEON GENERAL FOR THE FEBRUARY 16 00:00:40,273 --> 00:00:41,374 MEETING. 17 00:00:41,441 --> 00:00:42,575 CONCERNED THOMAS CANTALANI 18 00:00:42,642 --> 00:00:44,411 RETIRED, WE THANK HIM FOR 19 00:00:44,477 --> 00:00:46,079 PARTICIPATION ON THE BOARD. 20 00:00:46,146 --> 00:00:48,915 SO, MOVING ON TO BUSINESS, IT'S 21 00:00:48,982 --> 00:00:51,751 A PLEASURE TO WELCOME MS. JEAN 22 00:00:51,818 --> 00:01:00,393 GARCIA DAVIS AND MS. EDNA 23 00:01:00,460 --> 00:01:02,162 ISHAYIK TO DELIVER A REPORT FROM 24 00:01:02,228 --> 00:01:02,962 THE SURGEON GENERAL. 25 00:01:03,029 --> 00:01:03,463 >> THANK YOU. 26 00:01:03,530 --> 00:01:05,365 I WANT TO THANK THE ENTIRE BOARD 27 00:01:05,432 --> 00:01:06,566 FOR HAVING US AGAIN. 28 00:01:06,633 --> 00:01:08,501 IT'S AN HONOR AND PLEASURE TO BE 29 00:01:08,568 --> 00:01:09,469 HERE. 30 00:01:09,536 --> 00:01:13,106 THANK YOU SO MUCH TO DR. SHERRY 31 00:01:13,173 --> 00:01:13,773 AND WELCOME, DR. AZAD. 32 00:01:13,840 --> 00:01:17,577 THANK YOU ON BEHALF OF OUR TEAM 33 00:01:17,644 --> 00:01:19,879 AND DR. MURTHY FOR OUR WORK 34 00:01:19,946 --> 00:01:22,615 TOGETHER ON BEHALF OF THE ENTIRE 35 00:01:22,682 --> 00:01:25,018 AGENCY AND HHS AS WELL AS U.S. 36 00:01:25,084 --> 00:01:25,518 GOVERNMENT. 37 00:01:25,585 --> 00:01:30,990 WE'RE PLEASED TO BE HERE WITH 38 00:01:31,057 --> 00:01:32,459 YOU. 39 00:01:32,525 --> 00:01:36,429 DR. MURTHY PASSES GREETINGS AND 40 00:01:36,496 --> 00:01:37,030 GRATITUDE. 41 00:01:37,096 --> 00:01:39,199 I WANT TO WELCOME ALSO MY 42 00:01:39,265 --> 00:01:40,667 COLLEAGUE JOINING US TODAY, WHO 43 00:01:40,733 --> 00:01:43,102 WILL BE SHARING MORE ABOUT THE 44 00:01:43,169 --> 00:01:45,538 WORK ON SOCIAL CONNECTION AND 45 00:01:45,605 --> 00:01:50,310 COMMUNITY, FROM OUR OFFICE. 46 00:01:50,376 --> 00:01:50,977 EDNA ISHAYIK. 47 00:01:51,044 --> 00:01:53,346 THANK YOU FOR BEING HERE. 48 00:01:53,413 --> 00:01:59,018 I WANTED TO SHARE AS WE 49 00:01:59,085 --> 00:02:01,321 DISCUSSED LAST TIME, REMINDER TO 50 00:02:01,387 --> 00:02:02,155 PROTECT, PROMOTE, ADVANCE HEALTH 51 00:02:02,222 --> 00:02:04,090 AND SAFETY OF OUR NATION IS OUR 52 00:02:04,157 --> 00:02:05,959 MISSION, AND OUR ENTIRE HEALTH 53 00:02:06,025 --> 00:02:06,526 AND WELL-BEING. 54 00:02:06,593 --> 00:02:08,394 WE NEED TO HELP THE PUBLIC 55 00:02:08,461 --> 00:02:12,332 UNDERSTAND THE ISSUES AND HOW WE 56 00:02:12,398 --> 00:02:15,068 CAN WORK TOGETHER TO TAKE ACTION 57 00:02:15,134 --> 00:02:16,936 ON THESE IMPORTANT PUBLIC HEALTH 58 00:02:17,003 --> 00:02:17,203 ISSUES. 59 00:02:17,270 --> 00:02:18,638 SHARING OUR MOST RECENT ADVISORY 60 00:02:18,705 --> 00:02:22,342 FROM LAST SUMMER ON THE EPIDEMIC 61 00:02:22,408 --> 00:02:24,043 OF LONELINESS AND SOCIAL 62 00:02:24,110 --> 00:02:27,447 ISOLATION, AND WE'LL BE 63 00:02:27,514 --> 00:02:28,548 PROVIDING AN UPDATE. 64 00:02:28,615 --> 00:02:30,550 FOR TODAY, THIS IS OUR AGENDA, 65 00:02:30,617 --> 00:02:32,785 IF YOU WILL, FOR THE BRIEFING. 66 00:02:32,852 --> 00:02:34,487 I'LL GIVE A BRIEF UPDATE. 67 00:02:34,554 --> 00:02:37,790 I MENTIONED LAST TIME THE 68 00:02:37,857 --> 00:02:39,192 SURGEON GENERAL'S REPORT ON 69 00:02:39,259 --> 00:02:40,627 TOBACCO FORTHCOMING, WE HOPE IT 70 00:02:40,693 --> 00:02:42,695 WOULD BE AT THIS POINT BUT I CAN 71 00:02:42,762 --> 00:02:44,864 SHARE A BRIEF UPDATE AS WELL AS 72 00:02:44,931 --> 00:02:47,166 OUR WORK IN YOUTH MENTAL HEALTH 73 00:02:47,233 --> 00:02:49,068 AND SOCIAL MEDIA, AND MORE 74 00:02:49,135 --> 00:02:51,070 LARGELY AND BROADLY OUR WORK ON 75 00:02:51,137 --> 00:02:58,344 MENTAL HEALTH AND WELL-BEING. 76 00:02:58,411 --> 00:03:00,213 AND THEN WE'LL CLOSE WITH Q&A. 77 00:03:00,280 --> 00:03:01,881 WE WANT TO KEEP YOU ON TIME. 78 00:03:01,948 --> 00:03:04,584 YOU HAVE A BUSY DAY. 79 00:03:04,651 --> 00:03:06,619 AS A BRIEF UPDATE, AS WE 80 00:03:06,686 --> 00:03:08,121 DISCUSSED AT OUR LAST TOUCH 81 00:03:08,187 --> 00:03:10,623 POINT TOGETHER, OUR NEXT SURGEON 82 00:03:10,690 --> 00:03:13,026 GENERAL'S REPORT ON ELIMINATING 83 00:03:13,092 --> 00:03:14,994 TOBACCO-RELATED DISPARITIES WILL 84 00:03:15,061 --> 00:03:16,162 BE LAUNCHING, WE'RE HOPEFUL, IN 85 00:03:16,229 --> 00:03:17,764 THE NEXT FEW MONTHS, WE'LL 86 00:03:17,830 --> 00:03:20,266 CONTINUE TO KEEP YOU POSTED. 87 00:03:20,333 --> 00:03:22,468 IT'S CURRENTLY CONDITION THE HHS 88 00:03:22,535 --> 00:03:23,770 CLEARANCE PROCESS UNDERGOING A 89 00:03:23,836 --> 00:03:25,738 FIRST OF TWO REVIEWS AT THIS 90 00:03:25,805 --> 00:03:26,039 POINT. 91 00:03:26,105 --> 00:03:27,473 AND SO, AGAIN, WE'LL UPDATE YOU 92 00:03:27,540 --> 00:03:31,177 AS WE GET CLOSER TO ROLLOUT. 93 00:03:31,244 --> 00:03:33,146 AND NOTED HERE FOR THOSE WHO 94 00:03:33,212 --> 00:03:34,380 MAYBE WEREN'T WITH US LAST TIME, 95 00:03:34,447 --> 00:03:37,116 DID I SHARE THIS IS AN UPDATE 96 00:03:37,183 --> 00:03:39,085 FROM THE LAST SURGEON GENERAL'S 97 00:03:39,152 --> 00:03:42,689 REPORT ON SMOKING AND HEALTH, IN 98 00:03:42,755 --> 00:03:43,823 2020, SMOKING CESSATION, AND 99 00:03:43,890 --> 00:03:46,192 HOPEFULLY THIS ONE WILL COME OUT 100 00:03:46,259 --> 00:03:47,226 THIS YEAR. 101 00:03:47,293 --> 00:03:49,796 THE PREVIOUS ONE THAT WAS 102 00:03:49,862 --> 00:03:52,465 SPECIFIC TO HEALTH DISPARITIES 103 00:03:52,532 --> 00:03:55,068 FOR TOBACCO WAS IN 1998, AND 104 00:03:55,134 --> 00:03:57,570 THAT WAS -- THAT'S LISTED HERE. 105 00:03:57,637 --> 00:03:59,038 WE'RE EXCITED TO HELP ROLL THIS 106 00:03:59,105 --> 00:04:00,707 OUT, ESPECIALLY AT THIS TIME. 107 00:04:00,773 --> 00:04:03,977 I WANT TO SHARE TOO THAT IT'S 108 00:04:04,043 --> 00:04:05,612 QUITE A HISTORIC TIME. 109 00:04:05,678 --> 00:04:08,514 ON JANUARY 11 OF LAST MONTH WE 110 00:04:08,581 --> 00:04:10,416 DID ACTUALLY CELEBRATE THE FIRST 111 00:04:10,483 --> 00:04:13,519 EVER SURGEON GENERAL'S REPORT ON 112 00:04:13,586 --> 00:04:14,387 SMOKING AND HEALTH FROM 1964, 113 00:04:14,454 --> 00:04:18,458 AND SO WHILE THERE'S BEEN SO 114 00:04:18,524 --> 00:04:19,859 MUCH PROGRESS SINCE 1964, IN THE 115 00:04:19,926 --> 00:04:22,395 YEARS THAT FOLLOWED IN TERMS OF 116 00:04:22,462 --> 00:04:23,496 POLICY, PROGRAM, AND PRACTICE, 117 00:04:23,563 --> 00:04:27,767 WE HAVE FAR MORE TO DO 118 00:04:27,834 --> 00:04:29,502 ESPECIALLY FOR DISPARITIES THAT 119 00:04:29,569 --> 00:04:33,006 STILL CONTINUE TODAY, BUT EVEN 120 00:04:33,072 --> 00:04:33,906 FELT AMONG DISPROPORTIONATELY 121 00:04:33,973 --> 00:04:35,308 IMPACTED GROUPS. 122 00:04:35,375 --> 00:04:36,943 WE'RE EXCITED TO SHARE THE VIDEO 123 00:04:37,010 --> 00:04:38,077 WITH YOU ALSO. 124 00:04:38,144 --> 00:04:42,548 I CAN SHARE IT WITH YOU AFTER 125 00:04:42,615 --> 00:04:46,552 THAT DR. MURTHY SHARED ACROSS 126 00:04:46,619 --> 00:04:52,492 OUR PLATFORMS REGULAR NIGH -- 127 00:04:52,558 --> 00:04:55,695 RECOGNIZING THE ROLE NIH PLAYED, 128 00:04:55,762 --> 00:04:57,030 EXCITING TO LEARN MORE BEING 129 00:04:57,096 --> 00:04:58,698 PART OF THIS PROCESS TODAY. 130 00:04:58,765 --> 00:05:01,167 I ALSO DO WANT TO NOTE TOO ONE 131 00:05:01,234 --> 00:05:03,903 BRIEF UPDATE THAT WE CAN ALSO 132 00:05:03,970 --> 00:05:07,940 SHARE AFTER IS AROUND THE CDC 133 00:05:08,007 --> 00:05:10,009 HAS LAUNCHED ITS LATEST TIPS 134 00:05:10,076 --> 00:05:11,711 CAMPAIGN, THAT'S CONNECTED TO 135 00:05:11,778 --> 00:05:17,016 THIS WORK, AND SPECIFIC TO 136 00:05:17,083 --> 00:05:17,583 TOBACCO-RELATED DISPARITIES 137 00:05:17,650 --> 00:05:19,986 THERE ARE NEW LIVED EXPERIENCES 138 00:05:20,053 --> 00:05:21,988 THAT ARE SHARED FROM REAL 139 00:05:22,055 --> 00:05:23,289 VOICES, REAL PEOPLE, SO I CAN 140 00:05:23,356 --> 00:05:27,293 SHARE THAT WITH YOU AS WELL, 141 00:05:27,360 --> 00:05:30,363 NOTING THE CAMPAIGN WHICH 142 00:05:30,430 --> 00:05:32,465 STARTED IN 2012, THIS ACTUALLY 143 00:05:32,532 --> 00:05:33,566 HASN'T BEEN UPDATED SINCE JUST 144 00:05:33,633 --> 00:05:36,936 BEFORE THE PANDEMIC SO THERE ARE 145 00:05:37,003 --> 00:05:38,705 A FEW NEW VOICES, INCLUDING ONE, 146 00:05:38,771 --> 00:05:41,507 ALL OF THEM ARE COMPELLING IN 147 00:05:41,574 --> 00:05:44,644 TERMS OF IMPACT, NOT ONLY 148 00:05:44,711 --> 00:05:45,845 INDIVIDUAL IMPACT BUT ALSO 149 00:05:45,912 --> 00:05:47,246 FAMILY INTERPERSONAL AND 150 00:05:47,313 --> 00:05:48,481 COMMUNITY IMPACT, AND ANGIE IS 151 00:05:48,548 --> 00:05:50,450 ONE OF THE MORE RECENT ONES. 152 00:05:50,516 --> 00:05:53,319 SINCE THEY KICKED OFF THIS 153 00:05:53,386 --> 00:05:55,421 CAMPAIGN ACTUALLY YESTERDAY, THE 154 00:05:55,488 --> 00:05:59,158 CDC HAS BEEN WORKING WITH ANGIE 155 00:05:59,225 --> 00:06:01,994 ON A ROLLOUT ACROSS THE COUNTRY, 156 00:06:02,061 --> 00:06:03,329 AND ANGIE SHARES HER EXPERIENCE. 157 00:06:03,396 --> 00:06:05,398 I WANT TO NOTE SPECIFICALLY 158 00:06:05,465 --> 00:06:07,867 STARTING TO SMOKE AS A GAY TEEN 159 00:06:07,934 --> 00:06:10,336 WHEN SHE WAS 15, AND SMOKING 160 00:06:10,403 --> 00:06:11,170 MENTHOL CIGARETTES. 161 00:06:11,237 --> 00:06:14,507 I INVITE YOU TO TAKE A LOOK AT 162 00:06:14,574 --> 00:06:17,243 THE VIDEOS AND LISTEN TO HER 163 00:06:17,310 --> 00:06:20,179 EXPERIENCE THERE. 164 00:06:20,246 --> 00:06:22,482 AS I ALSO MENTIONED, I BELIEVE 165 00:06:22,548 --> 00:06:27,153 OUR LAST MEETING TOGETHER, OUR 166 00:06:27,220 --> 00:06:28,721 WORK CONTINUES AROUND ADVANCING 167 00:06:28,788 --> 00:06:30,423 YOUTH MENTAL HEALTH AND 168 00:06:30,490 --> 00:06:32,058 SUPPORTING YOUTH ACROSS THE 169 00:06:32,125 --> 00:06:34,060 COUNTRY WHEREVER THEY ARE, AND A 170 00:06:34,127 --> 00:06:37,330 REMINDER HERE OF THE LAUNCH OF 171 00:06:37,396 --> 00:06:40,767 OUR OTHER ADVISORY LAST SUMMER, 172 00:06:40,833 --> 00:06:41,968 SURGEON GENERAL'S ADVISORY ON 173 00:06:42,034 --> 00:06:42,969 SOCIAL MEDIA AND YOUTH MENTAL 174 00:06:43,035 --> 00:06:43,536 HEALTH. 175 00:06:43,603 --> 00:06:45,004 I WANT TO BRIEFLY UPDATE. 176 00:06:45,071 --> 00:06:46,472 I'M SURE YOU'VE SEEN IN THE 177 00:06:46,539 --> 00:06:48,107 NEWS, FOR THOSE WE DISCUSSED 178 00:06:48,174 --> 00:06:49,942 THIS LAST TIME, WHO ARE TOUCHED 179 00:06:50,009 --> 00:06:52,044 BY THIS AS PARENTS AND 180 00:06:52,111 --> 00:06:54,881 CAREGIVERS TO YOUTH OF ALL AGES, 181 00:06:54,947 --> 00:06:56,048 AND CHILDREN, DR. MURTHY 182 00:06:56,115 --> 00:06:58,084 CONTINUES TO STAY ENGAGED AND 183 00:06:58,151 --> 00:06:59,619 MORE RECENTLY SINCE THE LAUNCH 184 00:06:59,685 --> 00:07:02,555 OF THE INTERAGENCY TASK FORCE ON 185 00:07:02,622 --> 00:07:03,656 KIDS' ONLINE HEALTH AND SAFETY 186 00:07:03,723 --> 00:07:10,129 THAT WAS ESTABLISHED LAST MAY, 187 00:07:10,196 --> 00:07:14,200 THERE WAS A RECENT AMONG FIVE 188 00:07:14,267 --> 00:07:18,538 CEOS, BIG TECH, DISCUSSING KIDS 189 00:07:18,604 --> 00:07:19,839 ONLINE SAFETY ACT, KOSA. 190 00:07:19,906 --> 00:07:22,909 SINCE THAT TIME ONE OF THE 191 00:07:22,975 --> 00:07:24,243 INTERESTING AND NOTABLE IMPACTS 192 00:07:24,310 --> 00:07:26,078 AROUND PUBLIC SUPPORT OF THIS 193 00:07:26,145 --> 00:07:31,384 BILL AND THE MOST RECENT ONE 194 00:07:31,450 --> 00:07:32,285 CAME FROM SNAPCHAT ENDORSEMENT 195 00:07:32,351 --> 00:07:34,020 ON THE 25th OF JANUARY. 196 00:07:34,086 --> 00:07:35,521 WE CONTINUE TO STAY ENGAGED ON 197 00:07:35,588 --> 00:07:38,024 THIS BIPARTISAN BILL AS WELL AS 198 00:07:38,090 --> 00:07:41,127 TO REALLY HELP EDUCATE AND 199 00:07:41,194 --> 00:07:43,095 ENGAGE THE PUBLIC AND KEY 200 00:07:43,162 --> 00:07:44,897 STAKEHOLDERS ON THIS ISSUE. 201 00:07:44,964 --> 00:07:50,102 LASTLY, I'LL NOTE THAT AS WE'VE 202 00:07:50,169 --> 00:07:51,404 MENTIONED, THE FRAMEWORK FROM 203 00:07:51,470 --> 00:07:53,873 DR. MURTHY AND OUR OFFICE IN 204 00:07:53,940 --> 00:07:57,844 2022, AS WELL AS HEALTH WORKER 205 00:07:57,910 --> 00:07:59,946 ADVISORY BURNOUT AND WELL-BEING 206 00:08:00,012 --> 00:08:02,882 FROM EARLIER THAT SUMMER, SO 207 00:08:02,949 --> 00:08:04,784 NEARLY TWO YEARS, THE 208 00:08:04,851 --> 00:08:05,852 ANNIVERSARY OF THOSE, RECOGNIZE 209 00:08:05,918 --> 00:08:09,288 AND THANK FOR THE WORK YOU 210 00:08:09,355 --> 00:08:10,923 CONTINUE TO DO WITHIN YOUR -- 211 00:08:10,990 --> 00:08:13,092 WITHIN THE NATIONAL LIBRARY 212 00:08:13,159 --> 00:08:17,263 ACROSS YOUR HEALTH SYSTEMS AND 213 00:08:17,330 --> 00:08:18,197 ORGANIZATIONS AND INSTITUTIONS 214 00:08:18,264 --> 00:08:19,065 WHERE YOU'RE BASED. 215 00:08:19,131 --> 00:08:19,699 THANK YOU. 216 00:08:19,765 --> 00:08:21,100 WE CONTINUE TO DISSEMINATE THIS 217 00:08:21,167 --> 00:08:22,401 WORK AND STAY ENGAGED. 218 00:08:22,468 --> 00:08:26,005 I WANT TO FLAG MAINLY ON HEALTH 219 00:08:26,072 --> 00:08:27,607 WORKER WELL-BEING THAT THE 220 00:08:27,673 --> 00:08:31,878 NATIONAL ACADEMY OF MEDICINE, 221 00:08:31,944 --> 00:08:33,346 WHERE DR. MURTHY IS CO-CHAIR, 222 00:08:33,412 --> 00:08:35,648 CONTINUES TO PREPARE FOR WHAT IS 223 00:08:35,715 --> 00:08:38,117 BEING CALLED A NATIONAL HEALTH 224 00:08:38,184 --> 00:08:39,518 WORKFORCE WELL-BEING DAY, SO 225 00:08:39,585 --> 00:08:40,853 PLEASE MARK YOUR CALENDARS AND 226 00:08:40,920 --> 00:08:43,322 WE'LL BE SURE TO SHARE MORE 227 00:08:43,389 --> 00:08:46,292 ABOUT THAT AS WE HAVE A TOOL 228 00:08:46,359 --> 00:08:46,959 KIT. 229 00:08:47,026 --> 00:08:52,765 THAT WILL BE ON -- IT WILL KICK 230 00:08:52,832 --> 00:08:55,067 OFF MARCH 11 AND CULMINATE ON 231 00:08:55,134 --> 00:08:56,269 MARCH 18. 232 00:08:56,335 --> 00:08:58,004 I'LL PASS ON TO EDNA. 233 00:08:58,070 --> 00:08:58,371 >> THANK YOU. 234 00:08:58,437 --> 00:08:58,971 CAN YOU HEAR ME? 235 00:08:59,038 --> 00:09:01,941 ALL RIGHT. 236 00:09:02,008 --> 00:09:03,509 I'M AN ASSOCIATE DIRECTOR OF 237 00:09:03,576 --> 00:09:04,477 SCIENCE AND POLICY, OFFICE OF 238 00:09:04,543 --> 00:09:06,345 THE SURGEON GENERAL. 239 00:09:06,412 --> 00:09:08,281 THANKS FOR ALLOWING ME TO SHARE 240 00:09:08,347 --> 00:09:11,817 A LITTLE BIT TODAY ON OUR WORK 241 00:09:11,884 --> 00:09:12,885 ON SOCIAL CONNECTION. 242 00:09:12,952 --> 00:09:15,288 I'LL DO THE BRIEFEST OVERVIEW OF 243 00:09:15,354 --> 00:09:18,457 THE ISSUE IN A FEW WORDS, AND 244 00:09:18,524 --> 00:09:20,793 I'LL SHARE JUST A SAMPLING, A 245 00:09:20,860 --> 00:09:22,962 FEW SAMPLES OF THE WORK OUR 246 00:09:23,029 --> 00:09:25,164 OFFICE HAS BEEN DOING FOLLOWING 247 00:09:25,231 --> 00:09:28,801 THE RELEASE OF THE ADVISORY THAT 248 00:09:28,868 --> 00:09:31,504 JEANE JUST MENTIONED BACK IN 249 00:09:31,570 --> 00:09:33,739 MAY. 250 00:09:33,806 --> 00:09:35,508 AS THE ADVISORY SHARES, SOCIAL 251 00:09:35,574 --> 00:09:37,977 CONNECTION IS WHAT WE KNOW FROM 252 00:09:38,044 --> 00:09:40,713 RESEARCH, IT IS A FUNDAMENTAL 253 00:09:40,780 --> 00:09:42,248 HUMAN NEED. 254 00:09:42,315 --> 00:09:44,317 WE LIKEN IT TO BEING AS 255 00:09:44,383 --> 00:09:46,285 ESSENTIAL TO SURVIVAL AS FOOD 256 00:09:46,352 --> 00:09:46,919 AND WATER. 257 00:09:46,986 --> 00:09:49,989 IT CAN IMPROVE OUR HEALTH, 258 00:09:50,056 --> 00:09:51,857 EXTEND OUR LIFESPANS, AND THE 259 00:09:51,924 --> 00:09:52,959 RELATIONSHIPS AND INTERACTIONS 260 00:09:53,025 --> 00:09:56,796 OF OUR DAILY LIFE CAN ENHANCE 261 00:09:56,862 --> 00:09:58,097 WELL-BEING. 262 00:09:58,164 --> 00:09:59,999 ON THE FLIP SIDE, UNFORTUNATELY 263 00:10:00,066 --> 00:10:03,035 LACKING SOCIAL CONNECTION HAS 264 00:10:03,102 --> 00:10:04,904 VERY SERIOUS HEALTH 265 00:10:04,971 --> 00:10:06,505 CONSEQUENCES, CARDIOVASCULAR 266 00:10:06,572 --> 00:10:10,176 DISEASE, STROKE, DIABETES, 267 00:10:10,242 --> 00:10:11,243 DEPRESSION, COGNITIVE DECLINE, 268 00:10:11,310 --> 00:10:13,980 UNFORTUNATELY JUST A FEW, CAN 269 00:10:14,046 --> 00:10:14,947 SHORTEN LIVES. 270 00:10:15,014 --> 00:10:16,849 A LOT OF THAT RESEARCH IS 271 00:10:16,916 --> 00:10:17,383 CAUSAL. 272 00:10:17,450 --> 00:10:21,454 SO THIS IS TRULY A SERIOUS AREA 273 00:10:21,520 --> 00:10:25,524 OF CONCERN, ESPECIALLY WHEN WE 274 00:10:25,591 --> 00:10:26,292 LOOK AT ESTIMATED PREVALENCE 275 00:10:26,359 --> 00:10:27,593 RATES IN RECENT YEARS INCLUDING 276 00:10:27,660 --> 00:10:30,863 THE PANDEMIC. 277 00:10:30,930 --> 00:10:34,033 IT MAY HAVE BEEN UP TO ONE OUT 278 00:10:34,100 --> 00:10:36,435 OF TWO AMERICAN ADULTS 279 00:10:36,502 --> 00:10:38,104 EXPERIENCING SOME LONELINESS 280 00:10:38,170 --> 00:10:41,040 WITH ISOLATION RATES PEAKING AS 281 00:10:41,107 --> 00:10:41,374 WELL. 282 00:10:41,440 --> 00:10:44,443 SO, BETWEEN THE SEVERITY OF THE 283 00:10:44,510 --> 00:10:47,013 OUTCOMES AND THE POTENTIAL 284 00:10:47,079 --> 00:10:49,348 PREVALENCE RATES, WE FEEL IT'S A 285 00:10:49,415 --> 00:10:52,318 PUBLIC HEALTH -- MAJOR PUBLIC 286 00:10:52,385 --> 00:10:54,720 HEALTH CONCERN. 287 00:10:54,787 --> 00:10:57,556 BUT ADDRESSING SUCH A CONCERN IS 288 00:10:57,623 --> 00:11:00,426 SORT OF A SOCIETY-WIDE PROBLEM 289 00:11:00,493 --> 00:11:01,927 CONSIDERING ALL THE ELEMENTS AND 290 00:11:01,994 --> 00:11:04,697 FACTORS THAT GO INTO AN 291 00:11:04,764 --> 00:11:05,698 INDIVIDUAL'S LEVEL OF 292 00:11:05,765 --> 00:11:07,366 CONNECTEDNESS OR CAN CONTRIBUTE 293 00:11:07,433 --> 00:11:09,869 TO LONELINESS AND ISOLATION. 294 00:11:09,935 --> 00:11:11,470 WE SOMETIMES CALL IT EVERYTHING 295 00:11:11,537 --> 00:11:13,639 EVERYWHERE ALL AT ONCE BECAUSE 296 00:11:13,706 --> 00:11:17,176 IT'S DYNAMIC, IT'S ACROSS THE 297 00:11:17,243 --> 00:11:17,610 LIFESPAN. 298 00:11:17,676 --> 00:11:21,013 IT CHANGES OVER LIFE STAGES, ET 299 00:11:21,080 --> 00:11:23,983 CETERA, AND SOCIAL DEMOGRAPHICS 300 00:11:24,050 --> 00:11:25,584 COME INTO PLAY. 301 00:11:25,651 --> 00:11:27,053 WE HAVE OUR WORK CUT OUT FOR US 302 00:11:27,119 --> 00:11:29,388 AS WE SEEK TO ADDRESS THIS 303 00:11:29,455 --> 00:11:30,856 IMPORTANT ISSUE, BUT WE -- YOU 304 00:11:30,923 --> 00:11:32,391 KNOW, OVERALL, WE BELIEVE THAT 305 00:11:32,458 --> 00:11:36,562 WILL REQUIRE A SORT OF SOCIETAL 306 00:11:36,629 --> 00:11:36,829 APPROACH. 307 00:11:36,896 --> 00:11:39,632 DEFINITELY MORE THAN ANY ONE 308 00:11:39,698 --> 00:11:40,733 OFFICE OR ORGANIZATION CAN 309 00:11:40,800 --> 00:11:41,634 MOBILIZE ON ITS OWN. 310 00:11:41,700 --> 00:11:44,670 SO I'M GOING TO SHARE A FEW OF 311 00:11:44,737 --> 00:11:47,506 THE AREAS WHERE WE ARE SORT OF 312 00:11:47,573 --> 00:11:49,141 PUTTING SOME EMPHASIS. 313 00:11:49,208 --> 00:11:51,243 ONE IS RAISING AWARENESS SIMPLY 314 00:11:51,310 --> 00:11:54,180 ENSURING THAT THE PUBLIC AND 315 00:11:54,246 --> 00:11:56,115 OTHERS ARE AWARE AND SORT OF 316 00:11:56,182 --> 00:11:57,516 THINKING ABOUT THIS ISSUE. 317 00:11:57,583 --> 00:11:58,951 SO THAT'S NUMBER ONE. 318 00:11:59,018 --> 00:12:01,620 WE'RE DOING -- WE'RE EXERTING 319 00:12:01,687 --> 00:12:03,756 SOME EFFORT AROUND NATIONAL 320 00:12:03,823 --> 00:12:04,623 MEASURES AND PREVALENCE 321 00:12:04,690 --> 00:12:06,959 ESTIMATED AS I JUST MENTIONED, 322 00:12:07,026 --> 00:12:08,160 ALSO EXPLORING RESEARCH ON 323 00:12:08,227 --> 00:12:11,230 HEALTHY SOCIAL CONNECTION, WHAT 324 00:12:11,297 --> 00:12:13,499 CONSTITUTES HEALTHY SOCIAL 325 00:12:13,566 --> 00:12:13,799 CONNECTIONS. 326 00:12:13,866 --> 00:12:15,067 I'LL JUST SAY LITERALLY A FEW 327 00:12:15,134 --> 00:12:17,870 WORDS ABOUT EACH ONE. 328 00:12:17,937 --> 00:12:21,941 FIRST, YOU NEED ONE ASPECT OR 329 00:12:22,007 --> 00:12:24,610 ONE INITIATIVE THAT WE EMPLOYED 330 00:12:24,677 --> 00:12:25,678 FOR AWARENESS RAISING WAS 331 00:12:25,744 --> 00:12:27,746 NATIONAL TOUR THAT DR. MURTHY 332 00:12:27,813 --> 00:12:30,483 ENGAGED IN OVER THE PAST COUPLE 333 00:12:30,549 --> 00:12:31,083 MONTHS. 334 00:12:31,150 --> 00:12:33,886 HE STOPPED AT SEVERAL COLLEGES 335 00:12:33,953 --> 00:12:37,156 ACROSS THE COUNTRY, AND THE 336 00:12:37,223 --> 00:12:40,559 ENGAGEMENTS WERE DESIGNED TO BE 337 00:12:40,626 --> 00:12:42,061 FUN, INTERACTIVE EXPERIENCES, 338 00:12:42,128 --> 00:12:43,963 DESIGNED TO SORT OF ENGAGE YOUNG 339 00:12:44,029 --> 00:12:46,932 PEOPLE, ASK THEM TO CONNECT WITH 340 00:12:46,999 --> 00:12:50,102 OTHERS, INVITE THEM TO FIND WAYS 341 00:12:50,169 --> 00:12:54,273 TO INCORPORATE CONNECTION INTO 342 00:12:54,340 --> 00:12:56,008 THEIR DAILY ROUTINES. 343 00:12:56,075 --> 00:12:58,744 AND SORT OF SEE AND SHOW HOW 344 00:12:58,811 --> 00:13:02,648 THAT CAN STRENGTHEN 345 00:13:02,715 --> 00:13:04,517 RELATIONSHIPS AND ULTIMATELY 346 00:13:04,583 --> 00:13:06,952 LEAD TO HEALTHIER, FULLER, MORE 347 00:13:07,019 --> 00:13:07,353 PRODUCTIVE LIVES. 348 00:13:07,419 --> 00:13:08,821 THAT'S ONE ASPECT OF THE 349 00:13:08,888 --> 00:13:11,991 AWARENESS RAISING THAT WE'RE 350 00:13:12,057 --> 00:13:12,458 DOING. 351 00:13:12,525 --> 00:13:13,993 ANOTHER IS ONE ELEMENT THAT WE 352 00:13:14,059 --> 00:13:16,262 HAVE BEEN VERY FOCUSED ON IS 353 00:13:16,328 --> 00:13:18,697 MEASURES AND PREVALENCE 354 00:13:18,764 --> 00:13:19,165 ESTIMATES. 355 00:13:19,231 --> 00:13:21,500 I FEEL LIKE I HAVE A SYMPATHETIC 356 00:13:21,567 --> 00:13:24,503 AUDIENCE SO I WON'T SAY TOO MUCH 357 00:13:24,570 --> 00:13:25,371 WHY WE NEED STANDARDIZED 358 00:13:25,437 --> 00:13:29,441 MEASURES BUT I'LL JUST SAY THAT 359 00:13:29,508 --> 00:13:31,544 RIGHT NOW RESEARCH THAT HAS BEEN 360 00:13:31,610 --> 00:13:33,879 CONDUCTED HAS MOSTLY BEEN 361 00:13:33,946 --> 00:13:36,582 SMALLER CONVENIENT SAMPLES SO WE 362 00:13:36,649 --> 00:13:38,684 TRULY DO NEED STRONG 363 00:13:38,751 --> 00:13:40,219 STANDARDIZED MEASURES. 364 00:13:40,286 --> 00:13:43,355 WE DO HAVE SOME, THANKS TO 365 00:13:43,422 --> 00:13:44,456 AMAZING CHAMPIONS ACROSS THE 366 00:13:44,523 --> 00:13:47,193 GOVERNMENT, SOME FOLKS AT NIH AS 367 00:13:47,259 --> 00:13:50,129 WELL, WE HAVE ALREADY SEEN SOME 368 00:13:50,196 --> 00:13:54,667 MOMENTUM HERE THAT OUR OFFICE IS 369 00:13:54,733 --> 00:13:58,771 HOPING TO CAPITALIZE ON. 370 00:13:58,837 --> 00:14:01,807 THE NIEHS IN 2021 AND 2022 HAD A 371 00:14:01,874 --> 00:14:03,742 QUESTION ABOUT SOCIAL SUPPORT 372 00:14:03,809 --> 00:14:05,911 FOR ADOLESCENTS AND TEENS, AND 373 00:14:05,978 --> 00:14:11,317 THAT DATA IS AVAILABLE ONLINE, 374 00:14:11,383 --> 00:14:13,385 CDC'S BRSSS HAD AN OPTION MODULE 375 00:14:13,452 --> 00:14:14,820 FOR SOCIAL SUPPORT AND LONELY 376 00:14:14,887 --> 00:14:21,060 THAT IS THAT OVER 40 STATES 377 00:14:21,126 --> 00:14:23,562 UTILIZED, WHICH IS A HUGE 378 00:14:23,629 --> 00:14:25,831 VIGOROUS AND ROBUST DATASET, 379 00:14:25,898 --> 00:14:28,033 ONLINE FOR 2022, SOON TO COME 380 00:14:28,100 --> 00:14:30,436 FOR 2023. 381 00:14:30,502 --> 00:14:30,970 EXCITINGLY THANKS TO A 382 00:14:31,036 --> 00:14:33,272 PARTNERSHIP, WE WERE ABLE TO 383 00:14:33,339 --> 00:14:36,008 PLACE MODULES FOR SOCIAL 384 00:14:36,075 --> 00:14:37,009 SUPPORT, LONELINESS, SOCIAL 385 00:14:37,076 --> 00:14:39,078 ISOLATION ON THE HOUSEHOLD PULSE 386 00:14:39,144 --> 00:14:42,214 AND NATIONAL HEALTH PANEL 387 00:14:42,281 --> 00:14:44,683 SURVEYS THROUGH CENSUS, 388 00:14:44,750 --> 00:14:45,351 CONSIDERED EXPERIMENTAL BUT 389 00:14:45,417 --> 00:14:47,620 WE'RE EXCITED TO HAVE SOME DATA 390 00:14:47,686 --> 00:14:51,156 COMING IN THAT WILL BE 391 00:14:51,223 --> 00:14:55,160 NATIONALLY REPRESENTATIVE, AND I 392 00:14:55,227 --> 00:14:56,528 THINK THE DECEMBER 2023 DATA 393 00:14:56,595 --> 00:14:57,997 CYCLE SHOULD BE ONLINE IN THE 394 00:14:58,063 --> 00:14:58,964 NEXT WEEK OR TWO. 395 00:14:59,031 --> 00:15:00,065 MORE TO SAY. 396 00:15:00,132 --> 00:15:02,134 I'LL LEAVE IT AT THAT FOR NOW 397 00:15:02,201 --> 00:15:04,203 AND JUST SHARE BRIEFLY ABOUT THE 398 00:15:04,270 --> 00:15:08,140 LAST AREA I WANTED TO HIGHLIGHT 399 00:15:08,207 --> 00:15:09,575 TODAY, EXPLORING THE EVIDENCE 400 00:15:09,642 --> 00:15:11,644 BASE AROUND HEALTHY SOCIAL 401 00:15:11,710 --> 00:15:12,511 CONNECTION. 402 00:15:12,578 --> 00:15:13,846 SIMPLY A LITERATURE SCAN TO SEE 403 00:15:13,912 --> 00:15:16,582 IF THERE EVEN IS ENOUGH DATA AND 404 00:15:16,649 --> 00:15:18,450 EVIDENCE TO MAKE CLEAR AND 405 00:15:18,517 --> 00:15:21,186 HELPFUL STATEMENTS TO THE PUBLIC 406 00:15:21,253 --> 00:15:22,254 ABOUT WHAT CONSTITUTES HEALTHY 407 00:15:22,321 --> 00:15:24,456 SOCIAL CONNECTION, WHAT DO 408 00:15:24,523 --> 00:15:29,928 PEOPLE NEED, CAN WE SAY THE SAME 409 00:15:29,995 --> 00:15:32,064 WAY WE NEED TO EAT A CERTAIN 410 00:15:32,131 --> 00:15:37,136 NUMBER OF FRUITS AND VEGETABLE, 411 00:15:37,202 --> 00:15:39,271 COULD WE SEE HOW MUCH AND WHAT 412 00:15:39,338 --> 00:15:41,340 KIND OF SOCIAL CONNECTION HUMANS 413 00:15:41,407 --> 00:15:42,541 NEED, JUST QUESTIONS BECAUSE 414 00:15:42,608 --> 00:15:46,245 WE'RE EXPLORING THE LITERATURE 415 00:15:46,312 --> 00:15:49,882 AROUND THIS TO SEE -- TEST THE 416 00:15:49,948 --> 00:15:52,584 WATERS AND SEE WHAT'S THERE, IF 417 00:15:52,651 --> 00:15:55,054 THERE'S SOMETHING HELPFUL WE 418 00:15:55,120 --> 00:15:55,988 COULD AGGREGATE. 419 00:15:56,055 --> 00:15:56,955 SO THAT'S IT. 420 00:15:57,022 --> 00:15:58,724 THOSE ARE THREE OF THE MANY 421 00:15:58,791 --> 00:16:00,726 AREAS WE'RE FOCUSED ON EVEN JUST 422 00:16:00,793 --> 00:16:02,227 WITHIN SOCIAL CONNECTION AND YOU 423 00:16:02,294 --> 00:16:04,330 HEARD FROM JEANE THIS IS ONE OF 424 00:16:04,396 --> 00:16:06,632 OUR PRIORITY AREAS, SO I'LL 425 00:16:06,699 --> 00:16:08,067 LEAVE IT AT THAT AND SEE IF 426 00:16:08,133 --> 00:16:08,634 THERE ARE QUESTIONS. 427 00:16:08,701 --> 00:16:10,669 THANK YOU SO MUCH FOR INVITING 428 00:16:10,736 --> 00:16:11,603 US TO SHARE. 429 00:16:11,670 --> 00:16:14,206 >> ALL RIGHT. 430 00:16:14,273 --> 00:16:14,707 WONDERFUL. 431 00:16:14,773 --> 00:16:16,342 THIS IS JUST AN OUTSTANDING 432 00:16:16,408 --> 00:16:16,575 UPDATE. 433 00:16:16,642 --> 00:16:18,677 THANK YOU BOTH VERY MUCH. 434 00:16:18,744 --> 00:16:20,245 WE HAVE SOME TIME FOR 435 00:16:20,312 --> 00:16:20,546 DISCUSSION. 436 00:16:20,612 --> 00:16:23,182 SO I HAVE A QUESTION THAT I 437 00:16:23,248 --> 00:16:24,016 MIGHT WAIT TO SEE IF THERE ARE 438 00:16:24,083 --> 00:16:26,552 OTHERS ON THE CALL WHO WOULD 439 00:16:26,618 --> 00:16:35,227 LIKE TO FIRST JUMP IN. 440 00:16:35,294 --> 00:16:35,427 OKAY. 441 00:16:35,494 --> 00:16:36,829 DR. OGUNYEMI? 442 00:16:36,895 --> 00:16:38,831 >> I WAS INTRIGUED BY THE IDEA 443 00:16:38,897 --> 00:16:43,268 OF, YOU KNOW, AN ADVISORY ON THE 444 00:16:43,335 --> 00:16:46,438 NUMBER, QUALITY OF SOCIAL 445 00:16:46,505 --> 00:16:48,006 CONNECTIONS SIMILAR TO A LIBRARY 446 00:16:48,073 --> 00:16:48,407 ADVISORY. 447 00:16:48,474 --> 00:16:49,842 HOW DO YOU ENVISION THAT PLAYING 448 00:16:49,908 --> 00:16:50,109 OUT? 449 00:16:50,175 --> 00:16:51,477 I KNOW IT'S IN THE EARLY STAGES 450 00:16:51,543 --> 00:16:53,679 AND YOU'RE STILL THINKING ABOUT 451 00:16:53,746 --> 00:16:53,879 IT. 452 00:16:53,946 --> 00:16:56,415 >> YES, VERY EARLY. 453 00:16:56,482 --> 00:16:57,716 RIGHT NOW WE'RE WONDERING IF 454 00:16:57,783 --> 00:16:59,118 SUCH THINGS COULD EVEN BE 455 00:16:59,184 --> 00:16:59,385 STATED. 456 00:16:59,451 --> 00:17:01,420 IF ANYONE IS INTERESTED WE COULD 457 00:17:01,487 --> 00:17:02,755 PREVIEW WHAT WE HAVE. 458 00:17:02,821 --> 00:17:05,758 WE'RE VERY EARLY ON BUT LOOKS 459 00:17:05,824 --> 00:17:09,328 LIKE THERE'S SOME CLUSTERS, 460 00:17:09,395 --> 00:17:10,562 WHETHER RESEARCH IS RELATIVELY 461 00:17:10,629 --> 00:17:11,296 CLEAR. 462 00:17:11,363 --> 00:17:13,932 BUT THE QUESTION IS THEN COULD 463 00:17:13,999 --> 00:17:17,236 THESE THINGS BE STATED PUBLICLY. 464 00:17:17,302 --> 00:17:18,971 IT FEELS HAZY NOW. 465 00:17:19,037 --> 00:17:20,939 WE'D BE HAPPY TO WORKSHOP WITH 466 00:17:21,006 --> 00:17:21,240 ANY OF YOU. 467 00:17:21,306 --> 00:17:22,574 I THINK ULTIMATELY THE ANSWER IS 468 00:17:22,641 --> 00:17:25,544 I DO THINK MORE RESEARCH IS 469 00:17:25,611 --> 00:17:25,878 NEEDED. 470 00:17:25,944 --> 00:17:28,714 BOTH MORE TO BE COMPILED, WE'RE 471 00:17:28,781 --> 00:17:29,681 ONLY GETTING STARTED, ALSO I 472 00:17:29,748 --> 00:17:35,154 THINK MORE WILL NEED TO BE DONE 473 00:17:35,220 --> 00:17:37,055 FOR SURE. 474 00:17:37,122 --> 00:17:38,490 NOT A SATISFYING ANSWER BUT THAT 475 00:17:38,557 --> 00:17:42,961 GIVES A SENSE OF WHERE WE'RE AT. 476 00:17:43,028 --> 00:17:44,696 >> THANK YOU. 477 00:17:44,763 --> 00:17:45,631 >> COLONEL AZAD? 478 00:17:45,697 --> 00:17:46,765 >> FIRST OF ALL, THANK YOU FOR 479 00:17:46,832 --> 00:17:48,000 HAVING ME. 480 00:17:48,066 --> 00:17:51,403 THAT WAS A GREAT PRESENTATION. 481 00:17:51,470 --> 00:17:52,805 QUICK QUESTION ABOUT 482 00:17:52,871 --> 00:17:54,106 CONNECTIONS. 483 00:17:54,173 --> 00:17:56,074 NOW, DO YOU DISTINGUISH BETWEEN 484 00:17:56,141 --> 00:17:57,142 REAL LIFE CONNECTIONS AND 485 00:17:57,209 --> 00:17:58,710 VIRTUAL CONNECTIONS? 486 00:17:58,777 --> 00:18:01,547 BECAUSE THOSE ARE QUANTITATIVELY 487 00:18:01,613 --> 00:18:09,755 AND QUALITATIVELY DIFFERENT. 488 00:18:09,822 --> 00:18:09,955 OVER. 489 00:18:10,022 --> 00:18:11,890 >> THE RESEARCH IS STILL MURKY, 490 00:18:11,957 --> 00:18:13,325 I'LL PHRASE IT THAT WAY. 491 00:18:13,392 --> 00:18:14,827 WHAT WE FEEL WE COULD SAY RIGHT 492 00:18:14,893 --> 00:18:19,531 NOW IS IT'S IMPORTANT TO HAVE 493 00:18:19,598 --> 00:18:20,532 SOME IN-PERSON CONNECTION, THAT 494 00:18:20,599 --> 00:18:22,067 IF YOU HAVE NO IN-PERSON 495 00:18:22,134 --> 00:18:25,771 CONNECTION THAT WE SEE IN THE 496 00:18:25,838 --> 00:18:27,539 LITERATURE THAT'S NOT GOING TO 497 00:18:27,606 --> 00:18:29,608 BE IDEAL FOR HEALTH. 498 00:18:29,675 --> 00:18:33,745 TAKING INTO CONSIDERATION, YOU 499 00:18:33,812 --> 00:18:34,546 KNOW, DIFFERENCES IN 500 00:18:34,613 --> 00:18:35,147 DEMOGRAPHICS THAT MIGHT, YOU 501 00:18:35,214 --> 00:18:37,916 KNOW, REQUIRE FOLKS TO BE ONLINE 502 00:18:37,983 --> 00:18:40,219 MORE OR LESS, AND SO ALL OF 503 00:18:40,285 --> 00:18:42,054 THOSE SORT OF MORE -- THE FINER 504 00:18:42,120 --> 00:18:45,224 POINTS OF HOW MUCH AND HOW 505 00:18:45,290 --> 00:18:46,058 DIFFERENT IS IT AND, YOU KNOW, 506 00:18:46,125 --> 00:18:47,993 IF YOU TEXT YOUR MOM IS IT THE 507 00:18:48,060 --> 00:18:49,495 SAME AS HEARING HER VOICE, YOU 508 00:18:49,561 --> 00:18:51,897 KNOW, IS IT THE SAME AS GETTING 509 00:18:51,964 --> 00:18:52,831 A HUG? 510 00:18:52,898 --> 00:18:55,167 THOSE FINER POINTS I THINK ARE 511 00:18:55,234 --> 00:18:57,402 STILL MURKY IN THE LITERATURE. 512 00:18:57,469 --> 00:18:59,605 THAT'S ALL WE CAN SAY RIGHT NOW, 513 00:18:59,671 --> 00:19:01,473 AT THIS POINT IN OUR LITERATURE 514 00:19:01,540 --> 00:19:01,673 SCAN. 515 00:19:01,740 --> 00:19:03,408 BUT THERE IS A DISTINCTION, AND 516 00:19:03,475 --> 00:19:04,843 I THINK OTHERS OF YOU MAY KNOW 517 00:19:04,910 --> 00:19:08,680 MORE ABOUT THIS THAN ME. 518 00:19:08,747 --> 00:19:11,049 IT AFFECTS THE BRAIN DIFFERENTLY 519 00:19:11,116 --> 00:19:19,358 DEPENDING ON -- 520 00:19:19,424 --> 00:19:21,627 >> THANK YOU. 521 00:19:21,693 --> 00:19:21,927 >> STEVE? 522 00:19:21,994 --> 00:19:23,095 >> THANK YOU. 523 00:19:23,161 --> 00:19:24,496 JUST LETTING YOU KNOW NLM IS 524 00:19:24,563 --> 00:19:26,465 VERY INTERESTED IN THE DATA THAT 525 00:19:26,532 --> 00:19:27,766 YOU'RE COLLECTING AROUND HEALTHY 526 00:19:27,833 --> 00:19:31,069 SOCIAL CONNECTIONS, BOTH RAW 527 00:19:31,136 --> 00:19:32,704 DATA IN THE REPORT AND MAYBE 528 00:19:32,771 --> 00:19:34,006 OFFLINE WE COULD FOLLOW UP ON 529 00:19:34,072 --> 00:19:35,774 OPPORTUNITIES FOR US TO POINT TO 530 00:19:35,841 --> 00:19:37,943 OR HOST DATA TO MAKE SURE IT'S 531 00:19:38,010 --> 00:19:38,944 AVAILABLE TO RESEARCHERS. 532 00:19:39,011 --> 00:19:42,247 I THINK THIS IS REALLY POWERFUL, 533 00:19:42,314 --> 00:19:43,982 SOUNDS LIKE IT PART OF SOCIAL 534 00:19:44,049 --> 00:19:52,124 DETERMINANTS TO HELP IN THE 535 00:19:52,190 --> 00:19:53,392 PRIORITIES AT NIH. 536 00:19:53,458 --> 00:19:53,959 >> WONDERFUL. 537 00:19:54,026 --> 00:19:57,896 I MIGHT JUMP IN ON A RELATED 538 00:19:57,963 --> 00:19:58,597 QUESTION. 539 00:19:58,664 --> 00:20:01,066 I REALLY APPRECIATE BOTH 540 00:20:01,133 --> 00:20:01,400 PRESENTATIONS. 541 00:20:01,466 --> 00:20:03,602 MY QUESTION IS FOR EDNA. 542 00:20:03,669 --> 00:20:05,771 YOU KNOW, THE IMPORTANCE OF 543 00:20:05,837 --> 00:20:07,072 HEALTHY SOCIAL CONNECTIONS ARE 544 00:20:07,139 --> 00:20:07,439 CLEAR. 545 00:20:07,506 --> 00:20:13,245 AND I WANTED TO TOUCH ON THE -- 546 00:20:13,312 --> 00:20:14,546 I'M GETTING AN ECHO. 547 00:20:14,613 --> 00:20:15,047 OKAY. 548 00:20:15,113 --> 00:20:17,482 I WANTED TO TOUCH ON THE 549 00:20:17,549 --> 00:20:18,450 MEASURES AND PREVALENCE 550 00:20:18,517 --> 00:20:20,452 ESTIMATES, SO STANDARD MEASURES. 551 00:20:20,519 --> 00:20:21,453 WE LOVE STANDARDS, SO I'M 552 00:20:21,520 --> 00:20:23,288 WONDERING IF YOU CAN SHARE WITH 553 00:20:23,355 --> 00:20:28,026 ME A BIT MORE ABOUT HOW A 554 00:20:28,093 --> 00:20:28,994 RESEARCHER OR COMMUNITY MEMBERS 555 00:20:29,061 --> 00:20:30,729 WHO ARE INTERESTED IN THIS TOPIC 556 00:20:30,796 --> 00:20:34,566 CAN LEARN MORE OR BEGIN TO 557 00:20:34,633 --> 00:20:36,868 INCORPORATE STANDARD APPROACHES 558 00:20:36,935 --> 00:20:38,503 TO UNDERSTANDING SOCIAL 559 00:20:38,570 --> 00:20:39,071 CONNECTIONS. 560 00:20:39,137 --> 00:20:41,607 >> I'M AFRAID I'LL ONLY BE 561 00:20:41,673 --> 00:20:42,708 PARTIALLY HELPFUL BECAUSE WE'VE 562 00:20:42,774 --> 00:20:46,178 BEEN REALLY LOOKING AT THIS FROM 563 00:20:46,244 --> 00:20:49,982 THE PERSPECTIVE OF SORT OF 564 00:20:50,048 --> 00:20:50,616 FEDERAL GOVERNMENT SURVEYS, AND 565 00:20:50,682 --> 00:20:52,417 THAT -- YOU KNOW, THE REAL 566 00:20:52,484 --> 00:20:53,919 ESTATE THERE, I DON'T NEED TO 567 00:20:53,986 --> 00:20:55,354 TELL THIS GROUP, IS VERY TIGHT. 568 00:20:55,420 --> 00:20:58,523 SO WE END UP USING AND LOOKING 569 00:20:58,590 --> 00:21:00,959 AT THE BRIEFEST POSSIBLE 570 00:21:01,026 --> 00:21:01,693 MEASURES, WHICH AREN'T 571 00:21:01,760 --> 00:21:03,996 NECESSARILY -- WHICH WORK VERY 572 00:21:04,062 --> 00:21:05,297 WELL FOR PREVALENCE OR, YOU 573 00:21:05,364 --> 00:21:06,531 KNOW, SERVE THAT PURPOSE AND, 574 00:21:06,598 --> 00:21:08,066 YOU KNOW, A LOT OF TESTING IS 575 00:21:08,133 --> 00:21:10,369 STILL NEEDED TO ENSURE THAT 576 00:21:10,435 --> 00:21:12,571 WE'RE GETTING TO EXACTLY THE 577 00:21:12,638 --> 00:21:13,305 RIGHT QUESTIONS. 578 00:21:13,372 --> 00:21:17,909 BUT I THINK FOR RESEARCHERS, AND 579 00:21:17,976 --> 00:21:21,513 MAYBE MORE LOCAL GOVERNMENT, 580 00:21:21,580 --> 00:21:22,981 THERE MIGHT BE MORE -- SPACE IS 581 00:21:23,048 --> 00:21:25,384 TIGHT BUT THERE MAY BE MORE 582 00:21:25,450 --> 00:21:27,019 LEEWAY TO ASK QUESTIONS, ASK 583 00:21:27,085 --> 00:21:27,719 THEM DIFFERENT WAYS. 584 00:21:27,786 --> 00:21:31,056 SO I DON'T HAVE A GREAT ANSWER 585 00:21:31,123 --> 00:21:33,692 SORT OF HOLISTICALLY, BUT FOR 586 00:21:33,759 --> 00:21:39,264 THE FEDERAL GOVERNMENT WE HAVE A 587 00:21:39,331 --> 00:21:41,700 SLATE OF RECOMMENDED ITEMS AND 588 00:21:41,767 --> 00:21:44,469 MODULES THAT GET AT SOCIAL 589 00:21:44,536 --> 00:21:46,171 SUPPORT, LONELINESS, SOCIAL 590 00:21:46,238 --> 00:21:46,438 ISOLATION. 591 00:21:46,505 --> 00:21:48,707 WE KNOW THAT'S JUST A SAMPLING. 592 00:21:48,774 --> 00:21:51,209 THOSE ARE JUST KIND OF PIECES OF 593 00:21:51,276 --> 00:21:53,278 OVERALL SOCIAL CONNECTION. 594 00:21:53,345 --> 00:21:55,614 IT'S SO DYNAMIC AND SO 595 00:21:55,681 --> 00:21:56,448 MULTI-FACETED, BUT THOSE ARE THE 596 00:21:56,515 --> 00:21:58,550 AREAS THAT ARE MOST ASSOCIATED 597 00:21:58,617 --> 00:21:59,551 WITH HEALTH OUTCOMES. 598 00:21:59,618 --> 00:22:04,923 SO WE GO RIGHT TO THOSE AND HAVE 599 00:22:04,990 --> 00:22:06,792 A SET OF RECOMMENDATIONS. 600 00:22:06,858 --> 00:22:07,159 >> THANK YOU. 601 00:22:07,225 --> 00:22:08,593 ARE THOSE AVAILABLE ON THE 602 00:22:08,660 --> 00:22:09,961 SURGEON GENERAL'S WEBSITE? 603 00:22:10,028 --> 00:22:11,163 >> THEY ARE NOT CURRENTLY, BUT I 604 00:22:11,229 --> 00:22:15,767 WILL BE HAPPY TO SHARE THEM. 605 00:22:15,834 --> 00:22:17,636 FEEL FREE TO REACH OUT. 606 00:22:17,703 --> 00:22:18,904 WE HAVEN'T PUBLICIZED THAT AT 607 00:22:18,970 --> 00:22:20,872 THIS STAGE BUT WOULD BE HAPPY TO 608 00:22:20,939 --> 00:22:21,073 SHARE. 609 00:22:21,139 --> 00:22:21,540 >> SURE, WONDERFUL. 610 00:22:21,606 --> 00:22:23,108 THANK YOU SO MUCH. 611 00:22:23,175 --> 00:22:24,176 SUCH EXCITING WORK. 612 00:22:24,242 --> 00:22:31,283 ARE THERE ANY OTHER QUESTIONS? 613 00:22:31,349 --> 00:22:36,221 OH, PHILIP, YES, I SEE YOU. 614 00:22:36,288 --> 00:22:36,488 THANK YOU. 615 00:22:36,555 --> 00:22:37,789 >> FOR SOME REASON I'M CLAPPING 616 00:22:37,856 --> 00:22:40,859 AND RAISING AT THE SAME TIME. 617 00:22:40,926 --> 00:22:44,362 SO, I WAS CURIOUS, THIS IS MORE 618 00:22:44,429 --> 00:22:47,733 FROM A PERSONAL STORY, HOW DO 619 00:22:47,799 --> 00:22:49,501 THESE RECOMMENDATIONS TURN INTO 620 00:22:49,568 --> 00:22:51,269 FUNDING? 621 00:22:51,336 --> 00:22:52,938 BECAUSE I'M REALLY THINKING 622 00:22:53,004 --> 00:22:55,974 ABOUT SOME OF MY ELDERS IN THE 623 00:22:56,041 --> 00:22:59,044 FAMILY WHO ARE JUST KIND OF 624 00:22:59,111 --> 00:23:01,012 SITTING AT HOME, BECAUSE OF THE 625 00:23:01,079 --> 00:23:03,749 LACK OF SENIOR CENTERS, YOU 626 00:23:03,815 --> 00:23:05,317 KNOW, JUST THE ABILITY TO HAVE A 627 00:23:05,383 --> 00:23:07,385 BUS PICK THEM UP AND BRING THEM 628 00:23:07,452 --> 00:23:08,787 TO SENIOR CENTER FOR A FEW HOURS 629 00:23:08,854 --> 00:23:12,090 AND THEN BRING THEM BACK HOME. 630 00:23:12,157 --> 00:23:14,793 SO HOW DOES THIS I GUESS TURN 631 00:23:14,860 --> 00:23:17,629 INTO -- I GUESS THIS WOULD BE UP 632 00:23:17,696 --> 00:23:18,530 TO LEGISLATURES TO HAVE A 633 00:23:18,597 --> 00:23:20,465 STATEWIDE FUNDING AND MAKE ITS 634 00:23:20,532 --> 00:23:22,567 WAY LOCALLY AND MAYBE TO 635 00:23:22,634 --> 00:23:23,869 NON-PROFITS AND THINGS LIKE THAT 636 00:23:23,935 --> 00:23:26,171 BUT IS THERE A MECHANISM IN 637 00:23:26,238 --> 00:23:26,972 WHICH THESE RECOMMENDATIONS TURN 638 00:23:27,038 --> 00:23:32,744 INTO KIND OF AN ACTION ITEM AND 639 00:23:32,811 --> 00:23:33,912 MORE PROGRAMS FOR SOCIALIZATION? 640 00:23:33,979 --> 00:23:35,614 >> YES, I WISH I HAD A QUICK 641 00:23:35,680 --> 00:23:36,915 ANSWER FOR THAT. 642 00:23:36,982 --> 00:23:38,717 AND I THINK IT'S DIFFERENT. 643 00:23:38,784 --> 00:23:40,152 I THINK YOU'RE RIGHT, A LOT OF 644 00:23:40,218 --> 00:23:42,821 THIS IS LOCAL LEVEL. 645 00:23:42,888 --> 00:23:44,890 I'M SURE THE FEDERAL GOVERNMENT 646 00:23:44,956 --> 00:23:49,628 HAS THE ABILITY TO DO SOME OF 647 00:23:49,694 --> 00:23:52,230 THIS, AND HELP TO -- YOU KNOW, 648 00:23:52,297 --> 00:23:55,534 HELP TO ENCOURAGE THIS. 649 00:23:55,600 --> 00:23:58,804 I'LL SAY THAT DOT DOES HAVE SOME 650 00:23:58,870 --> 00:24:00,639 PROGRAMS, I CAN CONNECT YOU IF 651 00:24:00,705 --> 00:24:02,841 YOU'RE CURIOUS, THEY HAVE A FEW 652 00:24:02,908 --> 00:24:05,177 PROGRAMS THAT ARE REALLY GREAT 653 00:24:05,243 --> 00:24:06,545 FOR CONNECTING SENIORS. 654 00:24:06,611 --> 00:24:08,013 NONE OF US IS GOING TO DO THE 655 00:24:08,079 --> 00:24:08,580 WHOLE JOB. 656 00:24:08,647 --> 00:24:11,349 THAT'S WHY WE THINK OF THIS AS I 657 00:24:11,416 --> 00:24:12,284 SAID KIND OF SOCIETY-WIDE 658 00:24:12,350 --> 00:24:13,785 BECAUSE EVERYTHING IS JUST GOING 659 00:24:13,852 --> 00:24:16,755 TO GET AT ONE PIECE OF WHAT IS 660 00:24:16,822 --> 00:24:16,988 NEEDED. 661 00:24:17,055 --> 00:24:18,623 AND MAYBE EVEN JUST ONE PIECE 662 00:24:18,690 --> 00:24:20,292 FOR ONE POPULATION, SO NONE OF 663 00:24:20,358 --> 00:24:21,827 THIS THAT I'M ABOUT TO SAY IS 664 00:24:21,893 --> 00:24:26,631 MEANT TO BE A HOLISTIC ANSWER, 665 00:24:26,698 --> 00:24:28,800 BUT THERE ARE SOME BRIGHT SPOTS 666 00:24:28,867 --> 00:24:31,102 AND SOME ENCOURAGING AREAS WHERE 667 00:24:31,169 --> 00:24:33,772 FUNDING IS BEING USED FOR THIS 668 00:24:33,839 --> 00:24:35,507 SPECIFIC PURPOSE. 669 00:24:35,574 --> 00:24:38,243 DOT HAS SOME ITEMS. 670 00:24:38,310 --> 00:24:41,613 USDA HAS SOME PROGRAMS THAT USE 671 00:24:41,680 --> 00:24:43,048 FUNDING NOT JUST TO PROVIDE 672 00:24:43,114 --> 00:24:46,918 HEALTHY FOOD BUT TO CREATE 673 00:24:46,985 --> 00:24:47,953 CONNECTION AROUND THAT FOOD. 674 00:24:48,019 --> 00:24:50,055 IT MIGHT BE, YOU KNOW, COMMUNITY 675 00:24:50,121 --> 00:24:52,991 GARDENS AND OTHER PROGRAMS, SO 676 00:24:53,058 --> 00:24:54,759 THERE ARE AREAS THAT ARE FOCUSED 677 00:24:54,826 --> 00:24:57,629 ON THIS AND ARE PROVIDING 678 00:24:57,696 --> 00:25:00,799 FUNDING, BUT OVERALL I MEANING 679 00:25:00,866 --> 00:25:02,300 IT'S QUITE LOCAL, AND JUST SORT 680 00:25:02,367 --> 00:25:05,237 OF NEEDS TO BE PRIORITIZED. 681 00:25:05,303 --> 00:25:08,006 I THINK, YOU KNOW, CITIES AND 682 00:25:08,073 --> 00:25:09,107 TOWNS AND STATE GOVERNMENTS NEED 683 00:25:09,174 --> 00:25:11,543 TO SORT OF START BY MAKING THIS 684 00:25:11,610 --> 00:25:13,478 A PRIORITY AND THEN EVEN WITHOUT 685 00:25:13,545 --> 00:25:14,446 ADDITIONAL FUNDING, YOU KNOW, 686 00:25:14,512 --> 00:25:16,248 ONE OF THE ITEMS IN OUR 687 00:25:16,314 --> 00:25:18,850 ADVISORY, THERE'S A LOT THAT BE 688 00:25:18,917 --> 00:25:20,352 DONE WITH EXISTING FUNDING AND 689 00:25:20,418 --> 00:25:22,254 PROGRAMS THAT COULD BE TWEAKED 690 00:25:22,320 --> 00:25:24,456 AND REORIENTED TO ENHANCE THE 691 00:25:24,522 --> 00:25:25,957 SOCIAL CONNECTION THAT CAN YIELD 692 00:25:26,024 --> 00:25:28,159 FROM THOSE THINGS. 693 00:25:28,226 --> 00:25:29,895 SO, YOU KNOW, EXISTING 694 00:25:29,961 --> 00:25:30,295 STRUCTURE. 695 00:25:30,362 --> 00:25:32,731 SO, AGAIN, NOT A SATISFYING 696 00:25:32,797 --> 00:25:34,633 ANSWER BUT HOPEFULLY WE'LL HAVE 697 00:25:34,699 --> 00:25:36,468 A LOT OF EXPERIMENTATION AS THIS 698 00:25:36,534 --> 00:25:37,602 BECOMES MORE OF A PRIORITY WE'LL 699 00:25:37,669 --> 00:25:38,436 SEE MORE OF THAT. 700 00:25:38,503 --> 00:25:40,405 BUT I DO HAVE SOME EXAMPLES IF 701 00:25:40,472 --> 00:25:46,611 YOU WANT TO CONNECT AFTER, I CAN 702 00:25:46,678 --> 00:25:46,811 SHARE. 703 00:25:46,878 --> 00:25:48,179 >> WONDERFUL. 704 00:25:48,246 --> 00:25:49,180 THANK YOU. 705 00:25:49,247 --> 00:25:55,153 ANY OTHER COMMENTS OR QUESTIONS? 706 00:25:55,220 --> 00:25:55,387 OKAY. 707 00:25:55,453 --> 00:25:57,155 WELL, WE'LL GO AHEAD AND MOVE 708 00:25:57,222 --> 00:25:57,455 FORWARD. 709 00:25:57,522 --> 00:25:59,925 I'D LIKE TO THANK YOU FOR YOUR 710 00:25:59,991 --> 00:26:00,859 OUTSTANDING PRESENTATIONS, I'D 711 00:26:00,926 --> 00:26:03,828 ALSO LIKE TO THANK DR. MURTHY 712 00:26:03,895 --> 00:26:05,864 AND THE ENTIRE OFFICE FOR YOUR 713 00:26:05,931 --> 00:26:06,798 INCREDIBLE WORK ON BEHALF OF THE 714 00:26:06,865 --> 00:26:08,533 HEALTH OF OUR NATION. 715 00:26:08,600 --> 00:26:11,469 THANK YOU VERY MUCH. 716 00:26:11,536 --> 00:26:15,307 AND WE WILL NOW BE MOVING INTO 717 00:26:15,373 --> 00:26:17,909 OUR NEXT AGENDA ITEM WHICH IS 718 00:26:17,976 --> 00:26:22,948 APPROVAL OF THE SEPTEMBER 12 AND 719 00:26:23,014 --> 00:26:24,382 13, 2023 MINUTES. 720 00:26:24,449 --> 00:26:28,920 WOULD ANYONE LIKE TO MAKE A 721 00:26:28,987 --> 00:26:29,154 MOTION? 722 00:26:29,220 --> 00:26:30,755 >> MOVE TO ACCEPT THE MINUTES. 723 00:26:30,822 --> 00:26:32,290 >> THANK YOU, JIM HAS MOVED. 724 00:26:32,357 --> 00:26:37,329 IS THERE A SECOND? 725 00:26:37,395 --> 00:26:37,896 >> SECOND. 726 00:26:37,963 --> 00:26:39,064 >> THANK YOU. 727 00:26:39,130 --> 00:26:43,335 I SAW PHILIP'S HAND BUT HEARD 728 00:26:43,401 --> 00:26:43,568 MITCH. 729 00:26:43,635 --> 00:26:46,071 SO, THANK YOU. 730 00:26:46,137 --> 00:26:49,808 SO, THE APPROVAL OF SEPTEMBER 12 731 00:26:49,874 --> 00:26:52,544 AND 13, 2023 MINUTES PASSES. 732 00:26:52,610 --> 00:26:54,145 AND IT'S NOW TIME FOR APPROVAL 733 00:26:54,212 --> 00:26:55,714 OF FUTURE MEETING DATES. 734 00:26:55,780 --> 00:26:57,849 YOU CAN SEE THAT ON THE AGENDA. 735 00:26:57,916 --> 00:27:00,385 IS THERE DISCUSSION ON THIS 736 00:27:00,452 --> 00:27:02,821 ITEM? 737 00:27:02,887 --> 00:27:03,188 OKAY. 738 00:27:03,254 --> 00:27:06,191 SEEING NONE, THE NLM BOARD OF 739 00:27:06,257 --> 00:27:08,093 REGENTS 2026 WINTER MEETING WILL 740 00:27:08,159 --> 00:27:12,030 BE HELD ON FEBRUARY 10, 2026. 741 00:27:12,097 --> 00:27:13,698 NO VOTE IS NEEDED ON THIS. 742 00:27:13,765 --> 00:27:19,637 DO REACH OUT IF YOU HAVE ANY 743 00:27:19,704 --> 00:27:20,605 QUESTIONS ABOUT THAT DATE. 744 00:27:20,672 --> 00:27:23,341 YOU'LL SEE OTHER DATES OF NOTE 745 00:27:23,408 --> 00:27:29,681 CLOG MLA, WHICH IS BEING HELD IN 746 00:27:29,748 --> 00:27:32,317 MAY, AAMC MEETING IN ATLANTA, 747 00:27:32,384 --> 00:27:39,424 AND BOTH AMIA MEETINGS WHICH ARE 748 00:27:39,491 --> 00:27:43,161 BEING HELD, THIS IS THE MAIN 749 00:27:43,228 --> 00:27:47,799 MEETING 2024 IN SAN FRANCISCO, 750 00:27:47,866 --> 00:27:49,067 25 MEETING IN ATLANTA. 751 00:27:49,134 --> 00:27:49,267 OKAY. 752 00:27:49,334 --> 00:27:50,602 THANK YOU VERY MUCH. 753 00:27:50,668 --> 00:27:51,803 SO MOVING RIGHT ALONG ON THE 754 00:27:51,870 --> 00:27:53,705 AGENDA I WOULD NOW LIKE TO 755 00:27:53,772 --> 00:27:56,107 WELCOME DR. STEVE SHERRY TO GIVE 756 00:27:56,174 --> 00:27:59,811 THE REPORT FROM ACTING NATIONAL 757 00:27:59,878 --> 00:28:02,981 LIBRARY OF MEDICINE DIRECTOR. 758 00:28:03,048 --> 00:28:06,818 THANK YOU. 759 00:28:06,885 --> 00:28:07,786 >> HELLO, EVERYONE. 760 00:28:07,852 --> 00:28:08,887 FIRST AND FOREMOST I WANT TO 761 00:28:08,953 --> 00:28:10,555 WELCOME EVERYONE TO THE NLM 762 00:28:10,622 --> 00:28:12,724 BOARD OF REGENTS MEETING. 763 00:28:12,791 --> 00:28:14,526 IT IS A DELIGHT TO SEE YOU 764 00:28:14,592 --> 00:28:14,793 VIRTUALLY. 765 00:28:14,859 --> 00:28:15,794 THIS IS A VIRTUAL MEETING AS 766 00:28:15,860 --> 00:28:17,495 WILL BE THE ONE IN MAY. 767 00:28:17,562 --> 00:28:23,268 WE'LL MET AGAIN IN PERSON IN THE 768 00:28:23,334 --> 00:28:29,407 FALL. 769 00:28:29,474 --> 00:28:33,344 THERE WE GO. 770 00:28:33,411 --> 00:28:35,847 SO I'M PROUD TO SERVE AS ACTING 771 00:28:35,914 --> 00:28:38,483 DIRECTOR OF NLM, EVEN PROUDER OF 772 00:28:38,550 --> 00:28:41,086 THE TEAM AROUND ME WHO GATHERED 773 00:28:41,152 --> 00:28:43,888 HERE TODAY IN THE CONFERENCE 774 00:28:43,955 --> 00:28:45,223 CENTER IN BUILDING 38A. 775 00:28:45,290 --> 00:28:45,857 TOGETHER WE'RE COMMITTED TO THE 776 00:28:45,924 --> 00:28:48,359 FUTURE OF NLM AND CONTINUING ITS 777 00:28:48,426 --> 00:28:49,227 INCREDIBLE WORK. 778 00:28:49,294 --> 00:28:50,562 WHILE I PRESENT TO YOU TODAY, I 779 00:28:50,628 --> 00:28:52,497 KNOW I DON'T LEAD ALONE, IT'S 780 00:28:52,564 --> 00:28:54,165 WITH THIS SMART AND CAPABLE TIME 781 00:28:54,232 --> 00:28:58,136 THAT NLM DOES ITS GREAT WORK 782 00:28:58,203 --> 00:28:59,838 UNCOVERING INNOVATIVE 783 00:28:59,904 --> 00:29:01,005 APPROACHES, CONDUCTING 784 00:29:01,072 --> 00:29:04,442 BREAKTHROUGH RESEARCH, MAKING 785 00:29:04,509 --> 00:29:07,612 RESOURCES AVAILABLE TO EVERYONE. 786 00:29:07,679 --> 00:29:08,813 NLM HAS EXPERIENCED SOME 787 00:29:08,880 --> 00:29:10,115 TRANSITIONS IN RECENT MONTHS, 788 00:29:10,181 --> 00:29:11,783 I'M EXCITED TO INTRODUCE A FEW 789 00:29:11,850 --> 00:29:13,885 NEW LEADERS TO YOU TODAY AS WELL 790 00:29:13,952 --> 00:29:16,821 AS HONOR THOSE WHO LEFT NLM 791 00:29:16,888 --> 00:29:18,990 SINCE WE LAST MET. 792 00:29:19,057 --> 00:29:22,360 FIRST, THIS IS THE FIRST BOARD 793 00:29:22,427 --> 00:29:29,534 OF REGENTS IN MANY MEETINGS 794 00:29:29,601 --> 00:29:30,902 WITHOUT PATTI BRENNAN, WE WISH 795 00:29:30,969 --> 00:29:40,145 HER THE VERY BEST IN HER 796 00:29:40,211 --> 00:29:40,545 RETIREMENT. 797 00:29:40,612 --> 00:29:41,513 ALSO OLIVIER BODENREIDER, WHO 798 00:29:41,579 --> 00:29:43,515 RETIRED AFTER MANY YEARS OF 799 00:29:43,581 --> 00:29:45,283 OUTSTANDING SERVICE TO NLM. 800 00:29:45,350 --> 00:29:46,718 WE REMAIN GRATEFUL FOR ALL THAT 801 00:29:46,784 --> 00:29:48,686 HE DID TO ADVANCE RESEARCH AT 802 00:29:48,753 --> 00:29:55,026 NLM AND DRIVE THE OVERALL 803 00:29:55,093 --> 00:29:55,360 MISSION. 804 00:29:55,426 --> 00:29:58,429 WE HAVE THREE NEW MEMBERS THAT 805 00:29:58,496 --> 00:30:01,799 JOINED OUR LEADERSHIP TEAM. 806 00:30:01,866 --> 00:30:05,403 FIRST IS THE LISTER HILL CENTER 807 00:30:05,470 --> 00:30:06,771 ACTING DIRECTOR, MASTER OF 808 00:30:06,838 --> 00:30:07,272 SCIENCE JOHNS HOPKINS 809 00:30:07,338 --> 00:30:09,207 UNIVERSITY, BRINGS MORE THAN 26 810 00:30:09,274 --> 00:30:10,909 YEARS OF EXPERIENCE AT NLM TO 811 00:30:10,975 --> 00:30:12,644 THE TABLE, INCLUDING HAVING 812 00:30:12,710 --> 00:30:16,514 SERVED AS ACTING CHIEF OF THE 813 00:30:16,581 --> 00:30:19,417 APPLIED CLINICAL INFORMATICS 814 00:30:19,484 --> 00:30:19,651 BRANCH. 815 00:30:19,717 --> 00:30:20,952 WE'RE GRATEFUL TO SEE JIM STEP 816 00:30:21,019 --> 00:30:22,487 UP TO THIS ROLE. 817 00:30:22,554 --> 00:30:25,123 WE'RE LUCKY TO WELCOME BACK TO 818 00:30:25,190 --> 00:30:27,325 NLM DR. DINA PALTOO, WHERE SHE 819 00:30:27,392 --> 00:30:30,028 WAS ASSISTANT DIRECTOR FOR 820 00:30:30,094 --> 00:30:31,362 POLICY DEVELOPMENT. 821 00:30:31,429 --> 00:30:33,932 DR. PALTOO HAS COME ON DETAIL 822 00:30:33,998 --> 00:30:35,099 FROM NHLBI, HEART, LUNG AND 823 00:30:35,166 --> 00:30:36,968 BLOOD INSTITUTE HERE AT NIH, 824 00:30:37,035 --> 00:30:38,703 WHERE SHE WAS IN THE IMMEDIATE 825 00:30:38,770 --> 00:30:40,672 OFFICE OF THE DIRECTOR, ROLE OF 826 00:30:40,738 --> 00:30:43,174 ASSISTANT DIRECTOR OF SCIENTIFIC 827 00:30:43,241 --> 00:30:45,643 STRATEGY AND INNOVATION. 828 00:30:45,710 --> 00:30:50,048 RECEIVED HER BACHELOR'S IN 829 00:30:50,114 --> 00:30:52,717 MICROBIOLOGY, Ph.D. FROM 830 00:30:52,784 --> 00:30:53,818 HOWARD, MASTERS FROM JOHNS 831 00:30:53,885 --> 00:30:55,153 HOPKINS BLOOMBERG SCHOOL OF 832 00:30:55,220 --> 00:30:57,455 PUBLIC HEALTH, LOOK FORWARD TO 833 00:30:57,522 --> 00:31:01,893 HER HEALTH IMPLEMENTING POLICY 834 00:31:01,960 --> 00:31:03,328 FRAMEWORK AND OVERSEEING NLM 835 00:31:03,394 --> 00:31:04,796 RELATIONSHIPS ACROSS NIH WITH 836 00:31:04,862 --> 00:31:06,397 EXTERNAL GROUPS. 837 00:31:06,464 --> 00:31:12,036 SHE WILL WORK ASIDE MIKE HERDA. 838 00:31:12,103 --> 00:31:15,173 LASTLY DR. KIM PRUITT APPOINTED 839 00:31:15,240 --> 00:31:17,475 ACTING DIRECTOR OF NCBI, A LONG 840 00:31:17,542 --> 00:31:19,344 TENURED MEMBER OF NLM WITH 26 841 00:31:19,410 --> 00:31:23,915 YEARS OF SERVICE HERE, KIM 842 00:31:23,982 --> 00:31:26,050 RECEIVED A Ph.D. IN GENETICS 843 00:31:26,117 --> 00:31:31,489 AND DEVELOPMENT FROM CORNELL 844 00:31:31,556 --> 00:31:31,956 UNIVERSITY, COMPLETED 845 00:31:32,023 --> 00:31:33,658 POSTDOCTORAL STUDIES AS PART OF 846 00:31:33,725 --> 00:31:36,861 NCBI AT NLM, MOST RECENTLY CHIEF 847 00:31:36,928 --> 00:31:38,363 OF THE INFORMATION ENGINEERING 848 00:31:38,429 --> 00:31:43,868 BRANCH WITHIN NCBI, PLAYED A 849 00:31:43,935 --> 00:31:44,702 LEADING ROLE. 850 00:31:44,769 --> 00:31:49,207 PLEASE JOIN ME IN WELCOMING ALL 851 00:31:49,274 --> 00:31:51,209 THREE OUTSTANDING LEADERS TO OUR 852 00:31:51,276 --> 00:31:52,277 TEAM. 853 00:31:52,343 --> 00:31:54,879 NEXT IT'S EXCITING TO SHARE 854 00:31:54,946 --> 00:31:55,613 INCREDIBLE EXPERTISE AND 855 00:31:55,680 --> 00:31:56,781 ACCOMPLISHMENTS OF STAFF WITH 856 00:31:56,848 --> 00:31:58,082 YOU HERE TODAY. 857 00:31:58,149 --> 00:31:59,717 THROUGHOUT THE YEAR THE OFFICE 858 00:31:59,784 --> 00:32:01,653 OF COMMUNICATIONS AND PUBLIC 859 00:32:01,719 --> 00:32:03,588 LIAISON IS TASKED WITH SHARING 860 00:32:03,655 --> 00:32:04,222 ACCOMPLISHMENTS WITH THE PUBLIC. 861 00:32:04,289 --> 00:32:07,292 ONE OF THE WAYS THEY DO SO IS 862 00:32:07,358 --> 00:32:08,626 WITH VIDEOS FEATURING NOVEL 863 00:32:08,693 --> 00:32:10,395 SCIENTIFIC ADVANCES THAT NLM 864 00:32:10,461 --> 00:32:11,429 MAKES POSSIBLE. 865 00:32:11,496 --> 00:32:12,797 LET'S WATCH ONE NOW. 866 00:32:12,864 --> 00:32:17,835 THIS FEATURES THE WORK OF THE 867 00:32:17,902 --> 00:32:19,704 TEAM AS THEY UNRAVEL A 868 00:32:19,771 --> 00:32:22,573 LONGSTANDING MYSTERY OF HUMAN 869 00:32:22,640 --> 00:32:22,807 BIOLOGY. 870 00:32:22,874 --> 00:32:32,950 ♪ 871 00:32:48,733 --> 00:32:49,067 >> ONE FUNCTION, HUMAN 872 00:32:49,133 --> 00:32:58,876 PHYSIOLOGY ... 873 00:35:35,333 --> 00:35:37,101 >> THANK YOU. 874 00:35:37,168 --> 00:35:39,537 CONGRATULATIONS TO THE TEAM FOR 875 00:35:39,604 --> 00:35:42,240 THESE INSIGHTFUL FINDINGS AND 876 00:35:42,306 --> 00:35:43,541 MARVELOUS PRODUCTION BY OUR 877 00:35:43,608 --> 00:35:44,175 COMMUNICATIONS OFFICE, 878 00:35:44,242 --> 00:35:49,146 HIGHLIGHTS JUST HOW NLM CAN HELP 879 00:35:49,213 --> 00:35:51,349 FOSTER DIVERSITY AND DISCOVERY 880 00:35:51,415 --> 00:35:53,217 IN EXPLODING GENOMIC 881 00:35:53,284 --> 00:35:54,652 OPPORTUNITIES AROUND MICROBIOME 882 00:35:54,719 --> 00:35:55,953 AND METAGENOMES THAT ARE VERY 883 00:35:56,020 --> 00:35:59,257 MUCH CONNECTED TO HUMAN HEALTH 884 00:35:59,323 --> 00:36:00,491 AND DISEASE. 885 00:36:00,558 --> 00:36:04,462 NOW, I'D LIKE TO PIVOT AND ALSO 886 00:36:04,529 --> 00:36:06,130 REMARK THAT IN RECENT CHANGES 887 00:36:06,197 --> 00:36:08,432 DR. MONICA BERTAGNOLLI WAS 888 00:36:08,499 --> 00:36:12,103 RECENTLY APPOINTED AS 17th 889 00:36:12,169 --> 00:36:13,371 DIRECTOR OF NIH. 890 00:36:13,437 --> 00:36:14,005 OOPS. 891 00:36:14,071 --> 00:36:17,008 THERE WE GO. 892 00:36:17,074 --> 00:36:17,642 THANK YOU. 893 00:36:17,708 --> 00:36:19,911 DR. BERTAGNOLLI HAS A VISION FOR 894 00:36:19,977 --> 00:36:21,345 NIH, IT'S A POWERFUL ONE, AND 895 00:36:21,412 --> 00:36:23,481 PLACES NLM IN THE CENTER OF THE 896 00:36:23,548 --> 00:36:23,714 ACTION. 897 00:36:23,781 --> 00:36:25,716 SHE SAYS THAT OUR WORK IS NOT 898 00:36:25,783 --> 00:36:27,785 FINISHED WHEN WE JUST DELIVER 899 00:36:27,852 --> 00:36:28,619 SCIENTIFIC DISCOVERIES. 900 00:36:28,686 --> 00:36:30,221 OUR WORK AT NIH IS FINISHED WHEN 901 00:36:30,288 --> 00:36:38,563 ALL PEOPLE ARE LIVING LONG AND 902 00:36:38,629 --> 00:36:39,530 HELDY LIVES. 903 00:36:39,597 --> 00:36:41,265 NIH IS THE LABORATORY, CLINIC, 904 00:36:41,332 --> 00:36:41,632 COMMUNITY. 905 00:36:41,699 --> 00:36:44,168 WE HAVE TO RECOGNIZE PATIENTS 906 00:36:44,235 --> 00:36:47,972 ARE PATTERS IN IN -- PARTNERS IN 907 00:36:48,039 --> 00:36:48,806 DISCOVERY AND BENEFITS HAVE TO 908 00:36:48,873 --> 00:36:50,875 FLOW TO THEM. 909 00:36:50,942 --> 00:36:52,410 THE TACKLE THE COMPLEX PROBLEMS, 910 00:36:52,476 --> 00:36:54,946 NIH AIMS TO BRING MORE MEMBERS 911 00:36:55,012 --> 00:36:57,548 OF THE PUBLIC INTO RESEARCH 912 00:36:57,615 --> 00:36:58,616 ENTERPRISE AS PARTNERS IN THE 913 00:36:58,683 --> 00:37:00,518 DISCOVERY PROCESS. 914 00:37:00,585 --> 00:37:01,552 INCOME, AGE, RACE, ETHNICITY, 915 00:37:01,619 --> 00:37:03,020 GEOGRAPHIC LOCATION AND THINGS 916 00:37:03,087 --> 00:37:04,889 LIKE DISABILITY STATUS SHOULD 917 00:37:04,956 --> 00:37:06,290 NOT BE BARRIERS TO PARTICIPATING 918 00:37:06,357 --> 00:37:09,760 IN RESEARCH OR BENEFITING FROM 919 00:37:09,827 --> 00:37:11,162 RESEARCH ADVANCES. 920 00:37:11,228 --> 00:37:14,865 SHE GOES ON TO SAY IN HER VISION 921 00:37:14,932 --> 00:37:16,133 THAT PROGRESS IS ACCELERATED 922 00:37:16,200 --> 00:37:17,969 WHEN ADVANCED SCIENTIFIC METHODS 923 00:37:18,035 --> 00:37:25,042 SUCH AS NEW DATA ANALYTICS 924 00:37:25,109 --> 00:37:29,847 APPLY TO EVERYONE, DATASETS NEED 925 00:37:29,914 --> 00:37:31,582 TO BE INCLUSIVE, AND NEED TO BE 926 00:37:31,649 --> 00:37:34,085 ADAPTED IN RURAL AND URBAN 927 00:37:34,151 --> 00:37:35,186 SETTINGS. 928 00:37:35,252 --> 00:37:36,621 NIH IS COMMITTED TO HARNESSING 929 00:37:36,687 --> 00:37:40,958 POWER OF ARTIFICIAL INTELLIGENCE 930 00:37:41,025 --> 00:37:44,061 AND MACHINE LEARNING ACROSS 931 00:37:44,128 --> 00:37:45,029 COMMUNITIES. 932 00:37:45,096 --> 00:37:46,364 AND SPECIFICALLY, ADVANCED 933 00:37:46,430 --> 00:37:49,033 SCIENTIFIC METHODS, NEW 934 00:37:49,100 --> 00:37:50,101 TECHNOLOGIES ARE UNLOCKING 935 00:37:50,167 --> 00:37:52,303 POSSIBILITIES TO HARNESS DATA IN 936 00:37:52,370 --> 00:37:54,572 WAYS THAT ACHIEVE MORE 937 00:37:54,639 --> 00:37:56,040 DEFINITIVE RESULTS, LIKE THE 938 00:37:56,107 --> 00:37:58,843 VIDEO, WE'RE NOW CONNECTING GUT 939 00:37:58,909 --> 00:38:00,811 METABOLISM TO BILIRUBIN LEVELS 940 00:38:00,878 --> 00:38:03,881 AND IBD AND A LOT OF ADULT ONSET 941 00:38:03,948 --> 00:38:04,382 DISORDERS. 942 00:38:04,448 --> 00:38:05,616 NIH HAS LAUNCHED AND WILL 943 00:38:05,683 --> 00:38:09,520 CONTINUE TO LAUNCH INNOVATIVE 944 00:38:09,587 --> 00:38:11,455 AND AMBITIOUS INITIATIVES TO 945 00:38:11,522 --> 00:38:22,066 PROPEL FUSION OF BIOMEDICINE AND 946 00:38:22,867 --> 00:38:23,901 AL/ML, TO REIMAGINE THE LIBRARY 947 00:38:23,968 --> 00:38:29,407 FOR THE 21ST CENTURY CURES AS A 948 00:38:29,473 --> 00:38:30,174 CORNERSTONE INSTITUTION 949 00:38:30,241 --> 00:38:31,142 LEVERAGING AND ORGANIZING THIS 950 00:38:31,208 --> 00:38:31,809 DATA. 951 00:38:31,876 --> 00:38:34,645 HER VISION IS ASKING NLM TO 952 00:38:34,712 --> 00:38:35,780 DEVELOP STRATEGIES, FOUR HERE, 953 00:38:35,846 --> 00:38:39,150 TO INTEGRATE DATA FROM BASIC AND 954 00:38:39,216 --> 00:38:40,117 SOCIAL SCIENCE RESEARCH, PUBLIC 955 00:38:40,184 --> 00:38:50,728 HEALTH AND CLIP CAL -- CLINICAL 956 00:38:51,095 --> 00:38:52,997 CARE, INCREASE FAST CAPACITY FOR 957 00:38:53,064 --> 00:38:54,298 DATA HOSTING. 958 00:38:54,365 --> 00:38:57,301 THIRD, EMPLOY FEDERATED 959 00:38:57,368 --> 00:38:58,803 ARCHITECTURE TO CONNECT WITH THE 960 00:38:58,869 --> 00:39:01,505 BROADER COMMUNITY SO THERE'S AN 961 00:39:01,572 --> 00:39:04,341 INTEGRATED ECOSYSTEM OF DATA AND 962 00:39:04,408 --> 00:39:08,412 THE NLM BECOMES A CATALOG WHERE 963 00:39:08,479 --> 00:39:11,782 ONE CAN DISCOVER DATA AND BUILD 964 00:39:11,849 --> 00:39:13,150 A RICH TRAINING DATASET TO MAKE 965 00:39:13,217 --> 00:39:14,985 A NEW A.I. MODEL. 966 00:39:15,052 --> 00:39:16,821 FINALLY THE LIBRARY IS 967 00:39:16,887 --> 00:39:18,255 CHALLENGED TO PROVIDE EDUCATION 968 00:39:18,322 --> 00:39:19,056 AND HELP IN WORKFORCE 969 00:39:19,123 --> 00:39:22,393 DEVELOPMENT SO WE HAVE THE NEXT 970 00:39:22,460 --> 00:39:23,961 GENERATION OF SCIENTISTS TRAINED 971 00:39:24,028 --> 00:39:25,463 AND CAN PARTICIPATE IN THIS 972 00:39:25,529 --> 00:39:26,430 KNOWLEDGE ECONOMY. 973 00:39:26,497 --> 00:39:28,199 AGAIN, NOT JUST FROM URBAN 974 00:39:28,265 --> 00:39:29,834 SETTINGS BUT ACROSS ALL OF 975 00:39:29,900 --> 00:39:31,635 AMERICA, ALL TRIBES AND 976 00:39:31,702 --> 00:39:32,603 TERRITORIES, THERE'S AN 977 00:39:32,670 --> 00:39:34,805 OPPORTUNITY HERE TO BRING 978 00:39:34,872 --> 00:39:40,478 EVERYONE INTO THE ARTIFICIAL 979 00:39:40,544 --> 00:39:41,545 INTELLIGENCE WORKFORCE. 980 00:39:41,612 --> 00:39:43,414 SO DR. BERTAGNOLLI'S VISION 981 00:39:43,481 --> 00:39:44,849 DOVETAILS NICELY WITH THE THREE 982 00:39:44,915 --> 00:39:46,350 PILLARS OF THE CURRENT NLM 983 00:39:46,417 --> 00:39:48,018 STRATEGIC PLAN. 984 00:39:48,085 --> 00:39:52,957 AGAIN, THESE ARE TO ACCELERATE 985 00:39:53,023 --> 00:39:54,258 DISCOVERY AND ADVANCE HEALTH, TO 986 00:39:54,325 --> 00:39:55,426 REACH MORE PEOPLE THROUGH MORE 987 00:39:55,493 --> 00:40:00,898 WAYS, TO BUILD A WORKFORCE FOR 988 00:40:00,965 --> 00:40:02,700 DATA-DRIVEN RESEARCH AND HEALTH. 989 00:40:02,767 --> 00:40:04,201 RECENT ACCOMPLISH THES SHOWCASE 990 00:40:04,268 --> 00:40:06,103 NLM'S CAPACITY RIGHT NOW TO 991 00:40:06,170 --> 00:40:08,139 DISCOVER, TO LEAD, TO EMPOWER 992 00:40:08,205 --> 00:40:09,774 THE COMMUNITY. 993 00:40:09,840 --> 00:40:15,045 FOR RESEARCH, FOR EXAMPLE, OUR 994 00:40:15,112 --> 00:40:16,580 INTRAMURAL RESEARCH PROGRAM IRP 995 00:40:16,647 --> 00:40:20,417 SINCE WE LAST MET HAS PUBLISHED 996 00:40:20,484 --> 00:40:23,254 131 PEER REVIEWED PAPERS AND 29 997 00:40:23,320 --> 00:40:25,022 PRE-PRINTS IN 2023. 998 00:40:25,089 --> 00:40:26,791 MULTIPLE PUBLICATIONS LIKE THE 999 00:40:26,857 --> 00:40:32,363 VIDEO WE JUST SAW ARE IN TOP 1000 00:40:32,429 --> 00:40:34,832 TIER JOURNALS INCLUDING NATURE, 1001 00:40:34,899 --> 00:40:36,300 BIOINFORMATICS, NATURE 1002 00:40:36,367 --> 00:40:37,568 COMMUNICATIONS, JOURNAL OF 1003 00:40:37,635 --> 00:40:38,736 AMERICAN MEDICAL INFORMATICS 1004 00:40:38,803 --> 00:40:39,036 ASSOCIATION. 1005 00:40:39,103 --> 00:40:40,938 WE HAVE A TRAINING PROGRAM 1006 00:40:41,005 --> 00:40:44,775 WITHIN OUR IRP THAT HAS HOSTED 1007 00:40:44,842 --> 00:40:48,345 91 TRAINEES IN 2023 INCLUDING 1008 00:40:48,412 --> 00:40:49,780 POSTDOCTORAL FELLOWS, GRADUATE 1009 00:40:49,847 --> 00:40:52,183 STUDENTS, POST BACK, STUDENTS, 1010 00:40:52,249 --> 00:40:55,085 MEDICAL RESIDENTS, INTERNS, DATA 1011 00:40:55,152 --> 00:40:56,453 SCIENCE AND INFORMATICS SCHOLARS 1012 00:40:56,520 --> 00:40:57,655 RECEIVING AWARDS AND THAT SPEAKS 1013 00:40:57,721 --> 00:41:01,625 WELL TO THE CAPACITY AND 1014 00:41:01,692 --> 00:41:06,530 EXCELLENCE FOR TRAINING PROGRAM. 1015 00:41:06,597 --> 00:41:07,965 ON THE EXTRAMURAL SIDE 1016 00:41:08,032 --> 00:41:09,900 ADMINISTRATION TO NIH COMMON 1017 00:41:09,967 --> 00:41:12,069 FUND HIGH RISK, HIGH REWARD 1018 00:41:12,136 --> 00:41:13,370 GRANT APPLICATIONS. 1019 00:41:13,437 --> 00:41:15,005 AGAIN THESE HIGHLIGHT SOME 1020 00:41:15,072 --> 00:41:16,540 NOVELTY THAT WE'RE TRYING TO 1021 00:41:16,607 --> 00:41:17,708 DEVELOP AND FOSTER IN OUR 1022 00:41:17,775 --> 00:41:20,110 EXTRAMURAL PROGRAM. 1023 00:41:20,177 --> 00:41:21,946 FIRST TO KEVIN JOHNSON, THE 1024 00:41:22,012 --> 00:41:24,481 GRANT PROPOSAL AIMS TO ADDRESS 1025 00:41:24,548 --> 00:41:26,550 SIGNIFICANT TIME BURDEN IN 1026 00:41:26,617 --> 00:41:27,518 CLINICAL -- CLINICIAN BURNOUT 1027 00:41:27,585 --> 00:41:31,522 ASSOCIATED WITH CLINICAL AND 1028 00:41:31,589 --> 00:41:33,891 COUNTER DOCUMENTATION BY 1029 00:41:33,958 --> 00:41:35,092 DEVELOPING INNOVATIVE AUTOMATED 1030 00:41:35,159 --> 00:41:36,193 DOCUMENTATION ALGORITHMS THAT 1031 00:41:36,260 --> 00:41:37,995 CREATE CONCISE AND COUNTER 1032 00:41:38,062 --> 00:41:41,532 SUMMARIES IN REAL TIME. 1033 00:41:41,599 --> 00:41:44,768 AND DR. MAHDI IS PIONEERING 1034 00:41:44,835 --> 00:41:46,871 DEVELOPMENT OF DEEP 1035 00:41:46,937 --> 00:41:50,407 LEARNING-BASED ARCHITECTURES 1036 00:41:50,474 --> 00:41:52,142 AND TRAINING MECHANISMS TO 1037 00:41:52,209 --> 00:41:54,011 ADDRESS ADOPTION OF 1038 00:41:54,078 --> 00:41:57,514 RECONSTRUCTION, PARTICULARLY IN 1039 00:41:57,581 --> 00:41:58,415 MUSCULOSKELETAL IMAGING, 1040 00:41:58,482 --> 00:41:59,984 BRACHIAL PLEXUS DIAGNOSTIC 1041 00:42:00,050 --> 00:42:00,684 REALM, EXCITING OPPORTUNITIES 1042 00:42:00,751 --> 00:42:02,553 THAT ARE GOING TO HELP SHAPE 1043 00:42:02,620 --> 00:42:04,622 BEHAVIOR OF CLINICAL PRACTICE 1044 00:42:04,688 --> 00:42:06,590 AND ACCELERATE PRECISION OF 1045 00:42:06,657 --> 00:42:14,231 IMAGING AND TOOLS IN CLINICAL 1046 00:42:14,298 --> 00:42:16,867 CARE. 1047 00:42:16,934 --> 00:42:19,503 IN THE SECOND AIM, WE HAVE 1048 00:42:19,570 --> 00:42:23,440 COMMITMENTS REACHING PEOPLE IN 1049 00:42:23,507 --> 00:42:24,642 MORE WAYS THROUGH DISSEMINATION. 1050 00:42:24,708 --> 00:42:26,944 HERE ARE FOUR EXAMPLES RECENTLY 1051 00:42:27,011 --> 00:42:27,378 RELEASED. 1052 00:42:27,444 --> 00:42:33,851 FIRST IS LISTER HILL CENTER 1053 00:42:33,918 --> 00:42:36,887 MALARIA SCREENER PROJECT, WHICH 1054 00:42:36,954 --> 00:42:39,323 CAN EVALUATE BLOOD SMEARS IN A 1055 00:42:39,390 --> 00:42:41,091 REAL WORD TESTAMENT, GREAT 1056 00:42:41,158 --> 00:42:42,493 POTENTIAL FOR MAKING SCREENING 1057 00:42:42,559 --> 00:42:44,929 MORE EFFICIENT, AS OF DECEMBER 1058 00:42:44,995 --> 00:42:46,897 THAT SOFTWARE HAS BEEN 1059 00:42:46,964 --> 00:42:50,935 DOWNLOADED ALMOST 3,000 TIMES IN 1060 00:42:51,001 --> 00:42:52,770 39 COUNTRIES, ACTUALLY DOING 1061 00:42:52,836 --> 00:42:55,306 BLOOD SMEAR ANALYSIS LOOKING FOR 1062 00:42:55,372 --> 00:42:57,041 PAR SIDE LOADS, LEVEL 1 1063 00:42:57,107 --> 00:43:02,046 PRECISION WITH IMAGING 1064 00:43:02,112 --> 00:43:04,448 ENHANCEMENTS, SECOND, THIS IS AN 1065 00:43:04,515 --> 00:43:07,785 INTERACTIVE MAP THAT SHOWS THE 1066 00:43:07,851 --> 00:43:10,721 DISTRIBUTION OF ANTIMICROBIAL 1067 00:43:10,788 --> 00:43:12,923 RESISTANCE STRESS RESPONSE IN 1068 00:43:12,990 --> 00:43:16,493 VIRULENCE GENES AND ISOLATES 1069 00:43:16,560 --> 00:43:19,930 ACROSS THE WORLD, IN THE CONTEXT 1070 00:43:19,997 --> 00:43:28,238 OF EMERGING ANTIMICROBIAL 1071 00:43:28,305 --> 00:43:28,605 THREATS. 1072 00:43:28,672 --> 00:43:29,773 THE FCS-GX ALGORITHM HAS BEEN 1073 00:43:29,840 --> 00:43:35,179 DEVELOPED AS PART OF NIH CGR, 1074 00:43:35,245 --> 00:43:38,449 NOW IN DEVELOPMENT. 1075 00:43:38,515 --> 00:43:41,385 IN GALAXY FOR FAIR DATA 1076 00:43:41,452 --> 00:43:43,287 ANALYSIS, ANYONE CAN SCREEN 1077 00:43:43,354 --> 00:43:48,292 GENOMES PRIOR TO SUBMISSION TO 1078 00:43:48,359 --> 00:43:49,393 GENERAL BANK, CONTAMINATION 1079 00:43:49,460 --> 00:43:50,894 SCREENING IS THE CORE OF QUALITY 1080 00:43:50,961 --> 00:43:54,298 IN THAT WHEN YOU HAVE A SEQUENCE 1081 00:43:54,365 --> 00:43:55,632 SUBMITTING FOR AN ORGANISM IT'S 1082 00:43:55,699 --> 00:43:58,802 IMPORTANT DATA COMES FROM THAT 1083 00:43:58,869 --> 00:44:00,771 ORGANISM AND NOT CONTAMINATION. 1084 00:44:00,838 --> 00:44:02,706 KUDOS TO THEM, THE FACT THIS IS 1085 00:44:02,773 --> 00:44:07,011 IN GALAXY IS EXCITING, A BROADLY 1086 00:44:07,077 --> 00:44:07,911 USED PLATFORM SHOWING 1087 00:44:07,978 --> 00:44:11,382 INTERCONNECTION TO POPULAR TOOLS 1088 00:44:11,448 --> 00:44:12,950 AND SERVICES. 1089 00:44:13,017 --> 00:44:13,951 ClinVar SUPPORTS SOMATIC 1090 00:44:14,018 --> 00:44:16,186 VARIATION DATA, IN ADDITION TO 1091 00:44:16,253 --> 00:44:18,522 GERMLINE VARIATION DATA FOR 1092 00:44:18,589 --> 00:44:18,856 YEARS. 1093 00:44:18,922 --> 00:44:21,125 THIS WILL BE, FOR EXAMPLE, DATA 1094 00:44:21,191 --> 00:44:22,793 ASSOCIATED WITH CANCER GENOMES, 1095 00:44:22,860 --> 00:44:25,696 A POWERFUL SUPPLEMENT TO 1096 00:44:25,763 --> 00:44:26,797 UNDERSTANDING AND 1097 00:44:26,864 --> 00:44:27,698 CONTEXTUALIZING RISKS OF 1098 00:44:27,765 --> 00:44:34,905 VARIANTS IN SOMATIC CELLS AND 1099 00:44:34,972 --> 00:44:35,572 GERMLINE INHERITANCE. 1100 00:44:35,639 --> 00:44:37,941 THE OTHER THINGS FOR ENGAGEMENT 1101 00:44:38,008 --> 00:44:40,577 DISSEMINATION, TO NOTE THE NLM'S 1102 00:44:40,644 --> 00:44:41,478 OPEN SCIENCE COORDINATION GROUP 1103 00:44:41,545 --> 00:44:42,880 IS DEVELOPING A LIST OF PRIORITY 1104 00:44:42,946 --> 00:44:44,548 ACTIONS THAT ARE GOING TO BUILD 1105 00:44:44,615 --> 00:44:50,120 ON THE SUCCESS OF THE 2023 YEAR 1106 00:44:50,187 --> 00:44:51,121 OF OPEN SCIENCE. 1107 00:44:51,188 --> 00:44:53,290 IT WAS A GREAT YEAR. 1108 00:44:53,357 --> 00:44:55,692 THIS MOMENTUM IS BEING CARRIED 1109 00:44:55,759 --> 00:44:59,063 ON BY PARTICIPATING AND 1110 00:44:59,129 --> 00:44:59,696 PROMOTING WHITE HOUSE OFFICE OF 1111 00:44:59,763 --> 00:45:00,364 SCIENCE AND TECHNOLOGY POLICIES 1112 00:45:00,431 --> 00:45:03,600 YEAR OF OPEN SCIENCE RECOGNITION 1113 00:45:03,667 --> 00:45:03,867 CHALLENGE. 1114 00:45:03,934 --> 00:45:06,003 AND FINALLY THE DATA HEALTH 1115 00:45:06,070 --> 00:45:07,438 STANDARDS TEAM, I'M SORRY, 1116 00:45:07,504 --> 00:45:10,374 HEALTH DATA STANDARDS TEAM 1117 00:45:10,441 --> 00:45:12,910 RELEASED A NEW API ENDPOINT FOR 1118 00:45:12,976 --> 00:45:14,478 NLM RELEASE, PROVIDING UPDATED 1119 00:45:14,545 --> 00:45:25,022 LIST OF RELEASES FOR RxNORM, 1120 00:45:25,289 --> 00:45:26,924 SNOMED-CT AND UMLS. 1121 00:45:26,990 --> 00:45:28,125 I MENTIONED THE ECOSYSTEM THAT 1122 00:45:28,192 --> 00:45:30,761 WE'RE TRYING TO ESTABLISH THAT 1123 00:45:30,828 --> 00:45:32,529 WILL CONNECT AND CATALOG REMOTE 1124 00:45:32,596 --> 00:45:34,164 DATASETS IN ADDITION TO WHAT WE 1125 00:45:34,231 --> 00:45:36,133 HOLD IN OUR COLLECTION. 1126 00:45:36,200 --> 00:45:39,303 FIRST TEST IS BETA RELEASE OF 1127 00:45:39,369 --> 00:45:40,604 THE DATASET CATALOG. 1128 00:45:40,671 --> 00:45:42,806 THIS IS FREELY AVAILABLE CATALOG 1129 00:45:42,873 --> 00:45:45,209 OF BIOMEDICAL DATASETS AVAILABLE 1130 00:45:45,275 --> 00:45:45,909 FROM VARIOUS REPOSITORIES 1131 00:45:45,976 --> 00:45:48,846 DESIGNED TO HELP BIOMEDICAL 1132 00:45:48,912 --> 00:45:50,347 RESEARCHERS, MEDICAL LIBRARIANS, 1133 00:45:50,414 --> 00:45:53,417 NIH GRANTEES AND THE PUBLIC TO 1134 00:45:53,484 --> 00:45:56,487 DISCOVER BIOMEDICAL DATASETS 1135 00:45:56,553 --> 00:45:59,022 USING STANDARDIZED METADATA. 1136 00:45:59,089 --> 00:46:02,559 DATASET CATALOG IS INTERFACE TO 1137 00:46:02,626 --> 00:46:05,395 LEVERAGE DATASET METADATA MODEL, 1138 00:46:05,462 --> 00:46:07,397 DATMM, A METADATA SCHEMA THAT 1139 00:46:07,464 --> 00:46:10,334 PROVIDES BASIC COMMON MODEL FOR 1140 00:46:10,400 --> 00:46:11,602 DESCRIBING BIOMEDICAL DATASETS 1141 00:46:11,668 --> 00:46:15,239 AND REPOSITORIES, THAT WILL BE 1142 00:46:15,305 --> 00:46:22,913 FOUNDATIONAL TO GET RIGHT, TO 1143 00:46:22,980 --> 00:46:24,314 MAKE SURE IT'S COMPLETE AND 1144 00:46:24,381 --> 00:46:27,718 SUFFICIENT THAT YOU CAN, THROUGH 1145 00:46:27,784 --> 00:46:30,587 IT, AUTOMATICALLY BUILD -- 1146 00:46:30,654 --> 00:46:33,824 REQUEST SYSTEMS TO GATHER DATA 1147 00:46:33,891 --> 00:46:34,925 REMOTELY AND ASSEMBLE FOR 1148 00:46:34,992 --> 00:46:36,660 CONSOLIDATED COMPUTING TASKS. 1149 00:46:36,727 --> 00:46:38,662 IT WILL BE -- I THINK A 1150 00:46:38,729 --> 00:46:41,398 SIX-MONTH PILOT IS GOING TO HAVE 1151 00:46:41,465 --> 00:46:43,033 SOME FEEDBACK, I ENCOURAGE USERS 1152 00:46:43,100 --> 00:46:44,768 TO LOOK AND OFFER FEEDBACK ON 1153 00:46:44,835 --> 00:46:47,838 ITS UTILITY OR IDEAS FOR 1154 00:46:47,905 --> 00:46:48,939 IMPROVEMENT. 1155 00:46:49,006 --> 00:46:53,610 LITERATURE GROUP HAS ADDED OVER 1156 00:46:53,677 --> 00:46:55,179 14,000 PRE-PRINTS TO PubMed 1157 00:46:55,245 --> 00:46:58,982 IN PHASE 2 OF THE PRE-PRINT 1158 00:46:59,049 --> 00:47:00,751 PILOT LAST YEAR, ACCELERATING 1159 00:47:00,817 --> 00:47:03,453 ACCESS TO NIH-FUNDED RESEARCH 1160 00:47:03,520 --> 00:47:04,922 THROUGH PROVISIONAL OR 1161 00:47:04,988 --> 00:47:05,989 PRELIMINARY ANALYSIS OF 1162 00:47:06,056 --> 00:47:09,927 PRE-PRINTS OF MANUSCRIPTS. 1163 00:47:09,993 --> 00:47:12,229 THE PubMed AND INDEX SECTION 1164 00:47:12,296 --> 00:47:16,300 MTIX NEXT GENERATION OF 1165 00:47:16,366 --> 00:47:16,900 AUTOMATED MeSH INDEXING, A 1166 00:47:16,967 --> 00:47:18,068 MACHINE LEARNING ALGORITHM AP 1167 00:47:18,135 --> 00:47:19,903 TRIED TO CITATIONS AT THE TIME 1168 00:47:19,970 --> 00:47:21,838 OF LOADING TO PubMed 1169 00:47:21,905 --> 00:47:25,242 DATABASE, THIS DECREASES TIME 1170 00:47:25,309 --> 00:47:27,311 FOR MESH INDEXING, ENABLES NLM 1171 00:47:27,377 --> 00:47:29,279 TO SCALE MeSH INDEXING TO 1172 00:47:29,346 --> 00:47:30,714 VOLUME OF THE PUBLISHED 1173 00:47:30,781 --> 00:47:34,318 BIOMEDICAL LITERATURE KEEPING 1174 00:47:34,384 --> 00:47:35,953 THAT INDEXING CURRENT. 1175 00:47:36,019 --> 00:47:37,721 THE THIRD AIM WHICH IS OUR ARM 1176 00:47:37,788 --> 00:47:41,792 OF THE STRATEGIC PLAN, BUILDING 1177 00:47:41,858 --> 00:47:42,759 THIS WORKFORCE WITH DATA-DRIVEN 1178 00:47:42,826 --> 00:47:43,894 RESEARCH AND HEALTH, A COUPLE 1179 00:47:43,961 --> 00:47:45,629 ITEMS TO NOTE. 1180 00:47:45,696 --> 00:47:48,765 FIRST ON THE INTERNAL WORKFORCE 1181 00:47:48,832 --> 00:47:51,268 OF NIH FELLOWS, I THINK IT'S 1182 00:47:51,335 --> 00:47:52,936 NOTABLE TO MENTION THAT ON 1183 00:47:53,003 --> 00:47:55,138 DECEMBER 7 OF LAST YEAR, 1184 00:47:55,205 --> 00:47:57,307 MAJORITY OF THE VOTING NIH 1185 00:47:57,374 --> 00:47:58,976 FELLOWS UNITED VOTED TO BE 1186 00:47:59,042 --> 00:48:01,745 REPRESENTED BY THE INTERNATIONAL 1187 00:48:01,812 --> 00:48:04,114 UNION OF AUTOMOBILE AEROSPACE 1188 00:48:04,181 --> 00:48:04,982 AND AGRICULTURAL IMPLEMENT 1189 00:48:05,048 --> 00:48:07,084 WORKERS OF AMERICA. 1190 00:48:07,150 --> 00:48:09,052 U.A.W. UNION. 1191 00:48:09,119 --> 00:48:10,821 THE FEDERAL LABOR RELATIONS 1192 00:48:10,887 --> 00:48:12,556 SHORT, FLRA, CERTIFIED THE 1193 00:48:12,623 --> 00:48:14,524 BARGAINING UNIT ON DECEMBER 15, 1194 00:48:14,591 --> 00:48:14,725 2023. 1195 00:48:14,791 --> 00:48:18,462 AND THIS U.A.W. UNIT WILL COVER 1196 00:48:18,528 --> 00:48:19,863 APPROXIMATELY 5,000 FELLOWS 1197 00:48:19,930 --> 00:48:21,765 ACROSS THE NIH, INCLUDING 1198 00:48:21,832 --> 00:48:23,100 FELLOWS HERE AT NLM. 1199 00:48:23,166 --> 00:48:24,534 NIH IS LOOKING FORWARD TO 1200 00:48:24,601 --> 00:48:27,971 PARTNERING WITH THE U.A.W. TO 1201 00:48:28,038 --> 00:48:29,106 NEGOTIATE A HISTORIC COLLECTIVE 1202 00:48:29,172 --> 00:48:30,107 BARGAINING AGREEMENT FOR THE 1203 00:48:30,173 --> 00:48:31,908 PARTIES, TO MY KNOWLEDGE THIS IS 1204 00:48:31,975 --> 00:48:34,678 THE FIRST TIME OUR TRAINEE OR 1205 00:48:34,745 --> 00:48:36,647 FELLOWS HAVE BEEN UNIONIZED AND 1206 00:48:36,713 --> 00:48:38,815 REPRESENTED BY UNION. 1207 00:48:38,882 --> 00:48:39,950 COLLECTIVE BARGAINING WILL BE 1208 00:48:40,017 --> 00:48:40,784 ONGOING THROUGHOUT 2024. 1209 00:48:40,851 --> 00:48:44,288 MORE TO COME AS THIS PROCESS 1210 00:48:44,354 --> 00:48:44,655 EMERGES. 1211 00:48:44,721 --> 00:48:49,593 ANOTHER STEP THAT NLM IS TAKING 1212 00:48:49,660 --> 00:48:51,561 AROUND WORKFORCE DEVELOP. 1213 00:48:51,628 --> 00:48:54,231 IS RECOGNIZING THAT A.I. IS AN 1214 00:48:54,298 --> 00:48:56,199 IMPORTANT NEW FACET IN THE REALM 1215 00:48:56,266 --> 00:48:57,668 OF WORKFORCE DEVELOPMENT. 1216 00:48:57,734 --> 00:49:01,371 NLM IS BUILDING A.I. EXPERTISE 1217 00:49:01,438 --> 00:49:02,773 IN ALL DIVISIONS THROUGH PILOT 1218 00:49:02,839 --> 00:49:03,340 PROGRAMS. 1219 00:49:03,407 --> 00:49:05,175 WE KICKED OFF A GENERATIVE A.I. 1220 00:49:05,242 --> 00:49:07,377 PILOT WITH TEN USE CASES 1221 00:49:07,444 --> 00:49:07,778 RECENTLY. 1222 00:49:07,844 --> 00:49:10,314 AND THIS IS ACROSS NLM, USING 1223 00:49:10,380 --> 00:49:13,216 MICROSOFT OPEN A.I. AND AZURE 1224 00:49:13,283 --> 00:49:16,953 SAFE PLAYGROUND, SO WE HAVE A 1225 00:49:17,020 --> 00:49:19,156 FIRE WALL SPACE TO DO A.I. 1226 00:49:19,222 --> 00:49:21,124 DEVELOPMENT EXPERIMENTSES THAT 1227 00:49:21,191 --> 00:49:24,161 ARE SAFELY GROUND AND ISOLATED 1228 00:49:24,227 --> 00:49:26,263 FROM PUBLIC ACCESS, STAFF ARE 1229 00:49:26,330 --> 00:49:30,901 GAINING NEW KNOWLEDGE, 1230 00:49:30,967 --> 00:49:33,003 COLLABORATING ACROSS NLM AND 1231 00:49:33,070 --> 00:49:34,037 NIH, PRACTICAL USING OF MODELS, 1232 00:49:34,104 --> 00:49:36,973 ALSO COMMUNITY OF PRACTICE BEING 1233 00:49:37,040 --> 00:49:38,709 STOOD UP ACROSS NIH AND DIANNE 1234 00:49:38,775 --> 00:49:41,044 BABSKI IS ONE OF OUR DIVISION 1235 00:49:41,111 --> 00:49:43,413 LEADS HERE, LEADING THAT EFFORT 1236 00:49:43,480 --> 00:49:45,482 ALONG WITH NICK WEBER AT CIT. 1237 00:49:45,549 --> 00:49:47,250 OVER THE PAST FEW MONTHS THEY 1238 00:49:47,317 --> 00:49:48,352 HAVE EXPERIMENTED WITH NEW 1239 00:49:48,418 --> 00:49:51,021 TOOLS, IN THE PROCESS OF 1240 00:49:51,088 --> 00:49:51,722 DEVELOPING PROOF-OF-CONCEPT THAT 1241 00:49:51,788 --> 00:49:58,195 APPLIES TO THEIR USE CASES. 1242 00:49:58,261 --> 00:49:59,596 NEXT STAGE IS MEASURING RESULTS, 1243 00:49:59,663 --> 00:50:01,798 AND USING THE NIST FRAMEWORK FOR 1244 00:50:01,865 --> 00:50:02,666 MITIGATION AND ASSESSMENT. 1245 00:50:02,733 --> 00:50:05,635 THIS IS A BROOD RANGE OF 1246 00:50:05,702 --> 00:50:07,170 ACTIVITIES THAT COVER ALMOST 90 1247 00:50:07,237 --> 00:50:08,872 TO 100% OF THE NLM ACTIVITIES. 1248 00:50:08,939 --> 00:50:11,641 SO I THINK THIS IS REALLY TRYING 1249 00:50:11,708 --> 00:50:19,216 TO EXERCISE A.I. DEVELOPMENT IN 1250 00:50:19,282 --> 00:50:22,052 ALL REALM OF THE PORTFOLIO AND 1251 00:50:22,119 --> 00:50:23,153 PROGRAMS. 1252 00:50:23,220 --> 00:50:27,524 ANOTHER INVESTMENT IS HOST A 1253 00:50:27,591 --> 00:50:28,492 VISIT-A-THON, STORY TELLING WITH 1254 00:50:28,558 --> 00:50:29,059 DATA. 1255 00:50:29,126 --> 00:50:33,063 OVER THREE DAYS IN OCTOBER NLM 1256 00:50:33,130 --> 00:50:40,971 HELD A SECOND AT THE NATCHER 1257 00:50:41,037 --> 00:50:41,571 CENTER. 1258 00:50:41,638 --> 00:50:44,941 MANDATE WAS TO EXPLORE 1259 00:50:45,008 --> 00:50:48,445 HARNESSING OF DATA VISUALIZATION 1260 00:50:48,512 --> 00:50:49,980 TO UNCOVER INSIGHTS ABOUT 1261 00:50:50,046 --> 00:50:50,380 LIBRARY HOLDINGS. 1262 00:50:50,447 --> 00:50:53,049 THE FOUR TEAMS ADDRESS AND 1263 00:50:53,116 --> 00:50:54,818 DEVELOPED VISUALIZATIONS IN FOUR 1264 00:50:54,885 --> 00:50:57,220 DOMAINS, ANALYSIS OF PRE-PRINT 1265 00:50:57,287 --> 00:50:58,288 PILOT RESULTS, EVALUATION OF 1266 00:50:58,355 --> 00:51:00,590 CROWD SOURCE DATA FROM 1267 00:51:00,657 --> 00:51:05,962 DEVELOPING DATABASE INCLUDING 1268 00:51:06,029 --> 00:51:06,730 GENOMIC, GEOGRAPHIC, HISTORICAL 1269 00:51:06,797 --> 00:51:11,768 DATA, THE LEATHERS IN BOOK 1270 00:51:11,835 --> 00:51:12,936 BINDING, EVALUATION OF USAGE 1271 00:51:13,003 --> 00:51:15,472 TRENDS AND ACTIONABILITY OF 1272 00:51:15,539 --> 00:51:17,641 CUSTOMER EXPERIENCE DATA 1273 00:51:17,707 --> 00:51:22,179 GATHERED FROM NLM DIGITAL 1274 00:51:22,245 --> 00:51:22,446 PRODUCTS. 1275 00:51:22,512 --> 00:51:25,982 INSIGHTS REVEALING VALUE TO THE 1276 00:51:26,049 --> 00:51:28,518 COMMUNITY ACCESS, NATURE AND 1277 00:51:28,585 --> 00:51:36,593 INVENTORY AND PRESERVABILITY OF 1278 00:51:36,660 --> 00:51:37,828 BECOME BINDING MATERIALS, 1279 00:51:37,894 --> 00:51:40,931 BENCHMARKS FOR READING ROOM USE 1280 00:51:40,997 --> 00:51:42,599 AND TRENDS IN USER SATISFACTION. 1281 00:51:42,666 --> 00:51:45,101 I'D LIKE TO MAKE A FEW REMARKS 1282 00:51:45,168 --> 00:51:46,736 ABOUT THE BUDGET. 1283 00:51:46,803 --> 00:51:47,938 FIRST, WE REMAIN HOPEFUL THAT 1284 00:51:48,004 --> 00:51:51,241 THE BUDGET WILL NOT BE SUBJECT 1285 00:51:51,308 --> 00:51:52,209 TO DRASTIC CUTS. 1286 00:51:52,275 --> 00:51:54,945 YOU KNOW, EVEN IN A FLAT BUDGET, 1287 00:51:55,011 --> 00:51:56,379 WHAT WE'RE LOOKING AT, THERE 1288 00:51:56,446 --> 00:51:57,781 WILL BE SIGNIFICANT IMPACTS FOR 1289 00:51:57,848 --> 00:51:59,916 NLM WHICH I'D LIKE TO MAKE SURE 1290 00:51:59,983 --> 00:52:02,385 WE ALL RECOGNIZE. 1291 00:52:02,452 --> 00:52:04,387 FIRST, THAT AT FLAT BUDGET, 1292 00:52:04,454 --> 00:52:06,223 THERE'S GOING TO BE FUNDING 1293 00:52:06,289 --> 00:52:07,324 OPPORTUNITIES AND GRANT 1294 00:52:07,390 --> 00:52:09,159 PROPOSALS WE CANNOT FUND, 1295 00:52:09,226 --> 00:52:11,361 INNOVATION OPPORTUNITIES WE 1296 00:52:11,428 --> 00:52:12,929 CANNOT PURSUE, SOME GREAT IDEAS 1297 00:52:12,996 --> 00:52:13,830 AND POTENTIAL FOR DISCOVERIES 1298 00:52:13,897 --> 00:52:16,399 ARE LOST BECAUSE OF LACK OF 1299 00:52:16,466 --> 00:52:17,000 RESOURCES. 1300 00:52:17,067 --> 00:52:18,134 THERE'S A CONCERN THE NIH LEVEL 1301 00:52:18,201 --> 00:52:20,370 THAT WE COULD LOSE A GENERATION 1302 00:52:20,437 --> 00:52:21,771 OF EARLY CAREER INVESTIGATORS 1303 00:52:21,838 --> 00:52:23,807 WHEN PAYLINES FALL TOO LOW, AND 1304 00:52:23,874 --> 00:52:25,709 PEOPLE WILL LEAVE ACADEMIA AND 1305 00:52:25,775 --> 00:52:27,878 GO INTO INDUSTRY. 1306 00:52:27,944 --> 00:52:29,646 AND FINALLY, OUR INTRAMURAL 1307 00:52:29,713 --> 00:52:31,114 RESEARCH PROGRAM IS PARTICULARLY 1308 00:52:31,181 --> 00:52:33,083 SENSITIVE TO BUDGET CUTS, MOST 1309 00:52:33,149 --> 00:52:36,553 OF THE EXPENSES, FIXED PERSONNEL 1310 00:52:36,620 --> 00:52:38,421 COSTS AND IRP INVESTIGATORS HAVE 1311 00:52:38,488 --> 00:52:41,258 RESTRICTED ABILITY TO SEEK 1312 00:52:41,324 --> 00:52:44,227 ADDITIONAL FUNDING TO 1313 00:52:44,294 --> 00:52:45,629 COMPENSATE, SO INTRAMURAL 1314 00:52:45,695 --> 00:52:46,730 PROGRAM IS CONSTRAINED. 1315 00:52:46,796 --> 00:52:52,302 SO JUST AS WE LOOK AT THIS YEAR 1316 00:52:52,369 --> 00:52:53,436 PARTNERSHIPS WITH STAKEHOLDERS 1317 00:52:53,503 --> 00:52:54,504 ARE CRUCIAL, LOOKING FOR WAYS TO 1318 00:52:54,571 --> 00:52:57,407 ADVANCE THE MISSION AND BRING 1319 00:52:57,474 --> 00:52:58,808 RELEVANT PARTIES TOGETHER, 1320 00:52:58,875 --> 00:53:00,110 ACADEMIC AND NON-PROFITS AND 1321 00:53:00,176 --> 00:53:02,078 OTHERS EXTERNAL, ALIGNED WITH 1322 00:53:02,145 --> 00:53:03,513 OUR MISSION. 1323 00:53:03,580 --> 00:53:06,283 SO, AROUND THE APPROPRIATIONS 1324 00:53:06,349 --> 00:53:07,017 ITSELF, JUST TO STATE WHAT I 1325 00:53:07,083 --> 00:53:08,585 THINK IS STILL IN THE NEWS, 1326 00:53:08,652 --> 00:53:11,288 THERE'S NO FINAL BUDGET FOR NIH 1327 00:53:11,354 --> 00:53:14,591 OR NLM YET FOR FISCAL YEAR 24. 1328 00:53:14,658 --> 00:53:16,560 WE'RE CURRENTLY OPERATING UNDER 1329 00:53:16,626 --> 00:53:17,227 THE THIRD CONTINUING RESOLUTION, 1330 00:53:17,294 --> 00:53:19,963 THIS IS GOING TO END ON MARCH 8. 1331 00:53:20,030 --> 00:53:22,032 AT THIS POINT THE FINAL 1332 00:53:22,098 --> 00:53:23,333 APPROPRIATION FOR NLM BUDGET IS 1333 00:53:23,400 --> 00:53:25,101 STILL TO BE DETERMINED. 1334 00:53:25,168 --> 00:53:26,836 BUT WHAT WE'RE EXPECTING WOULD 1335 00:53:26,903 --> 00:53:29,139 BE FLAT FOR 23, MOST INSTITUTES 1336 00:53:29,205 --> 00:53:31,207 AT NIH ARE PREPARING FOR 1337 00:53:31,274 --> 00:53:33,610 LIKELIHOOD OF TIGHT FUNDING IN 1338 00:53:33,677 --> 00:53:36,546 THIS FY 24 BUDGET AS I SAID A 1339 00:53:36,613 --> 00:53:37,681 SECOND AREA. 1340 00:53:37,747 --> 00:53:43,320 JUST A SHOW THE HISTORY OF NLM, 1341 00:53:43,386 --> 00:53:44,888 $498 MILLION IS OUR EXPECTATION. 1342 00:53:44,955 --> 00:53:46,690 AGAIN WE'RE UNDER A C.R. 1343 00:53:46,756 --> 00:53:50,794 WE DON'T KNOW THE FINAL NUMBER 1344 00:53:50,860 --> 00:53:51,227 YET. 1345 00:53:51,294 --> 00:53:54,864 OUR EXPECT IS THE SAME, 498. 1346 00:53:54,931 --> 00:53:56,833 THE PROCESS AND ACTIVITIES FOR 1347 00:53:56,900 --> 00:53:57,667 THE PRESIDENT'S BUDGET 1348 00:53:57,734 --> 00:54:00,103 SUBMISSION FOR 25 IS STILL 1349 00:54:00,170 --> 00:54:00,470 ONGOING. 1350 00:54:00,537 --> 00:54:05,709 AND AT THIS POINT THERE ARE NO 1351 00:54:05,775 --> 00:54:07,143 BUDGET FIGURES AVAILABLE 1352 00:54:07,210 --> 00:54:07,410 PUBLICLY. 1353 00:54:07,477 --> 00:54:09,412 SO GIVEN ALL OF THE BUDGET 1354 00:54:09,479 --> 00:54:10,947 PLANNING AND CONSTRAINTS I JUST 1355 00:54:11,014 --> 00:54:12,682 TALKED ABOUT, I WANT TO REMIND 1356 00:54:12,749 --> 00:54:15,685 THE BOARD AND MEMBERS LISTENING 1357 00:54:15,752 --> 00:54:16,753 THE BUDGET PLANNING FOR THIS 1358 00:54:16,820 --> 00:54:19,055 YEAR BEGAN LAST YEAR WHEN WE 1359 00:54:19,122 --> 00:54:19,990 STARTED TO UNDERSTAND WHAT THIS 1360 00:54:20,056 --> 00:54:25,095 YEAR WAS GOING TO LOOK LIKE. 1361 00:54:25,161 --> 00:54:25,695 OUR TEAM ESTABLISHED GUIDING 1362 00:54:25,762 --> 00:54:27,998 PRINCIPLES MOVING INTO THIS 1363 00:54:28,064 --> 00:54:28,198 YEAR. 1364 00:54:28,264 --> 00:54:31,501 THESE I'M JUST SHARING THEM, TO 1365 00:54:31,568 --> 00:54:32,369 COLLECT, CURATE, PRESERVE 1366 00:54:32,435 --> 00:54:33,069 BIOMEDICAL INFORMATION AND 1367 00:54:33,136 --> 00:54:34,904 CONNECT IT TO THE WORLD. 1368 00:54:34,971 --> 00:54:38,174 WE WANT TO PROVIDE CREDIBLE 1369 00:54:38,241 --> 00:54:39,042 ACCESSIBLE INFORMATION RESOURCES 1370 00:54:39,109 --> 00:54:41,578 AT SCALE TO ADVANCE RESEARCH AND 1371 00:54:41,645 --> 00:54:42,312 HEALTH. 1372 00:54:42,379 --> 00:54:43,246 CONDUCT AND SUPPORT 1373 00:54:43,313 --> 00:54:44,214 TRANSFORMATIVE RESEARCH THAT 1374 00:54:44,280 --> 00:54:49,386 ADVANCES INFORMATION AND LIBRARY 1375 00:54:49,452 --> 00:54:50,787 SCIENCE, ENGINEERING, AND 1376 00:54:50,854 --> 00:54:51,321 TECHNOLOGY. 1377 00:54:51,388 --> 00:54:53,423 FINALLY LEAD EXCELLENCE FOR 1378 00:54:53,490 --> 00:54:54,124 RESILIENCE, RELIABILITY, 1379 00:54:54,190 --> 00:54:56,026 REPRESENTATION FOR ALL 1380 00:54:56,092 --> 00:54:57,794 INFORMATION SCIENCE. 1381 00:54:57,861 --> 00:54:59,996 FROM THESE GUIDING PRINCIPLES WE 1382 00:55:00,063 --> 00:55:00,964 HAVE IDENTIFIED FIVE PRIORITY 1383 00:55:01,031 --> 00:55:04,067 AREAS WE COULD TRY TO PRESERVE 1384 00:55:04,134 --> 00:55:05,802 IN 2024 WITH RESOURCES WE HAVE. 1385 00:55:05,869 --> 00:55:08,304 WE WANT TO DEVELOP INTENTIONAL 1386 00:55:08,371 --> 00:55:09,372 STRATEGIES FOR DEVELOPING OUR 1387 00:55:09,439 --> 00:55:11,341 UNIFIED COLLECTION. 1388 00:55:11,408 --> 00:55:14,678 WE WANT TO ACCESS NLM -- ENSURE 1389 00:55:14,744 --> 00:55:16,613 ACCESS TO OUR COLLECTIONS, NLM'S 1390 00:55:16,680 --> 00:55:17,480 CONNECTIONS, WHILE PROTECTING 1391 00:55:17,547 --> 00:55:18,682 RIGHTS OF USERS AND 1392 00:55:18,748 --> 00:55:19,349 CONTRIBUTORS. 1393 00:55:19,416 --> 00:55:24,154 WE WANT TO SUPPORT EARLY CAREER 1394 00:55:24,220 --> 00:55:24,721 RESEARCHERS. 1395 00:55:24,788 --> 00:55:25,922 SUPPORT HIGH VALUE TECHNICAL 1396 00:55:25,989 --> 00:55:26,923 INFRASTRUCTURE THAT EMBRACES THE 1397 00:55:26,990 --> 00:55:27,557 FUTURE. 1398 00:55:27,624 --> 00:55:29,125 ENSURE THAT OUR DECISIONS ARE 1399 00:55:29,192 --> 00:55:30,193 DRIVEN BY DATA. 1400 00:55:30,260 --> 00:55:31,394 WE CONTINUE TO APPLY THESE 1401 00:55:31,461 --> 00:55:35,398 PRIORITIES AS WE PLAN AND 1402 00:55:35,465 --> 00:55:38,201 EXECUTE OUR 2024 BUDGET. 1403 00:55:38,268 --> 00:55:39,269 WE'VE COVERED CHANGES TO 1404 00:55:39,335 --> 00:55:40,103 LEADERSHIP TEAM. 1405 00:55:40,170 --> 00:55:43,039 IT TAKES MANY MORE KEY STAFF TO 1406 00:55:43,106 --> 00:55:46,509 RUN THE WORLD'S LARGEST 1407 00:55:46,576 --> 00:55:47,343 BIOMEDICAL LIBRARY. 1408 00:55:47,410 --> 00:55:50,213 SINCE THE LAST BOARD MEETING NLM 1409 00:55:50,280 --> 00:55:51,915 SAW A COUPLE RETIREMENTS AND 1410 00:55:51,981 --> 00:55:53,616 DEPARTURES, FIRST DR. TOM MADDEN 1411 00:55:53,683 --> 00:55:54,584 RETIRED LAST WEEK AFTER MORE 1412 00:55:54,651 --> 00:55:59,089 THAN 30 YEARS OF SERVICE TO NLM 1413 00:55:59,155 --> 00:55:59,522 AND NCBI. 1414 00:55:59,589 --> 00:56:02,625 SINCE 1994 TOM HAS OVERSEEN 1415 00:56:02,692 --> 00:56:04,360 DEVELOPMENT OF NCBI BLAST. 1416 00:56:04,427 --> 00:56:06,563 HIS EFFORTS SHAPED BLAST INTO 1417 00:56:06,629 --> 00:56:07,664 THE BUSIEST SEQUENCE SERVICE IN 1418 00:56:07,731 --> 00:56:10,633 THE WORLD, GOLD STANDARD FOR 1419 00:56:10,700 --> 00:56:11,568 STAND-ALONE SEQUENCE SIMILARITY 1420 00:56:11,634 --> 00:56:12,469 SEARCH TOOLS. 1421 00:56:12,535 --> 00:56:15,205 IMPACT HAS BEEN IMMENSE, WE'LL 1422 00:56:15,271 --> 00:56:18,074 MISS HIM. 1423 00:56:18,141 --> 00:56:19,442 JENNIFER MARILL RECENTLY RETIRED 1424 00:56:19,509 --> 00:56:21,745 AFTER SEARCHING AS CHIEF OF 1425 00:56:21,811 --> 00:56:26,583 TECHNICAL SERVICES, WITHIN THE 1426 00:56:26,649 --> 00:56:28,885 DIVISION OF LIBRARY OPERATIONS, 1427 00:56:28,952 --> 00:56:39,496 A GREAT ASSET TO DIANNE BABSKI'S 1428 00:56:42,132 --> 00:56:42,632 GROUP. 1429 00:56:42,699 --> 00:56:43,867 AND WEEP HOPE TO COLLABORATE TO 1430 00:56:43,933 --> 00:56:44,834 THESE TWO DOCTORS IN THE FUTURE. 1431 00:56:44,901 --> 00:56:46,436 WE'VE HAD THE PLEASURE OF 1432 00:56:46,503 --> 00:56:48,037 WELCOMING NEW TALENT TO THE NLM 1433 00:56:48,104 --> 00:56:49,973 TEAM CELEBRATING NEW ROLES FOR 1434 00:56:50,039 --> 00:56:53,910 SOME FAMILIAR FACES. 1435 00:56:53,977 --> 00:56:56,713 FIRST DR. DAVID LANDSMAN, HAS 1436 00:56:56,780 --> 00:57:03,119 BEEN NAMED ACTING BRANCH CHIEF 1437 00:57:03,186 --> 00:57:05,321 FOR COMPUTATIONAL BRANCH CHRB, 1438 00:57:05,388 --> 00:57:07,791 IN ADDITION TO CBB BRANCH CHIEF 1439 00:57:07,857 --> 00:57:12,762 AND SENIOR INVESTIGATOR IN IRP. 1440 00:57:12,829 --> 00:57:17,801 WE'VE WELCOMED DR. LUNA AS EARL 1441 00:57:17,867 --> 00:57:18,802 STADTMAN TENURE-TRACK 1442 00:57:18,868 --> 00:57:20,870 INVESTIGATOR, A DISTINGUISHED 1443 00:57:20,937 --> 00:57:25,909 COMPUTATIONAL BIOLOGIST RENOWNED 1444 00:57:25,975 --> 00:57:27,277 FOR DEVELOPING APPLICATIONS IN 1445 00:57:27,343 --> 00:57:30,680 THE FIELD OF CANCER RESEARCH, A 1446 00:57:30,747 --> 00:57:32,482 Ph.D. IN BIOINFORMATICS, LEADS 1447 00:57:32,549 --> 00:57:37,253 A TEAM IN INNOVATIVE APPROACHES 1448 00:57:37,320 --> 00:57:42,859 TO ASPECTS OF DATA SCIENCE 1449 00:57:42,926 --> 00:57:43,359 RESEARCH. 1450 00:57:43,426 --> 00:57:45,628 WE HAVE MS. ANNA RIPPLE, 1451 00:57:45,695 --> 00:57:48,665 MASTER'S IN LIBRARY SCIENCE, 1452 00:57:48,731 --> 00:57:52,702 ACTING BRANCH CHIEF OF APPLIED 1453 00:57:52,769 --> 00:57:56,840 CLINICAL INFORMATICS BRANCH FOR 1454 00:57:56,906 --> 00:57:59,576 ACIB, AND WILL PROVIDE STRATEGIC 1455 00:57:59,642 --> 00:58:03,413 DIRECTION FOR ACIB ACTIVITIES 1456 00:58:03,479 --> 00:58:05,849 IMPLEMENTING STRATEGIC VISION. 1457 00:58:05,915 --> 00:58:08,885 PREVIOUSLY SERVED AS INFORMATION 1458 00:58:08,952 --> 00:58:13,256 RESEARCH SPECIALIST, ALUMNI OF 1459 00:58:13,323 --> 00:58:15,391 NLM ASSOCIATE FELLOWS PROGRAM. 1460 00:58:15,458 --> 00:58:17,794 ALSO VICTORIA RUCKER, NOW 1461 00:58:17,861 --> 00:58:20,630 SERVING AS DEPUTY EXECUTIVE 1462 00:58:20,697 --> 00:58:22,732 OFFICER, JOINED FROM THE NIH 1463 00:58:22,799 --> 00:58:24,133 OFFICE OF THE DIRECTOR, WAS 1464 00:58:24,200 --> 00:58:26,469 DIRECTOR OF OFFICE FOR WORKFORCE 1465 00:58:26,536 --> 00:58:28,771 MANAGEMENT AND PROGRAMS, CHIEF 1466 00:58:28,838 --> 00:58:29,839 DIVERSITY OFFICER. 1467 00:58:29,906 --> 00:58:31,908 ADDITION IS AN EXCITING ONE, WE 1468 00:58:31,975 --> 00:58:33,576 LOOK FORWARD TO LEADERSHIP AND 1469 00:58:33,643 --> 00:58:34,878 VISION SHE WILL BRING. 1470 00:58:34,944 --> 00:58:36,646 PLEASE JOIN ME IN WELCOMING OUR 1471 00:58:36,713 --> 00:58:38,181 DISTINGUISHED NEW COLLEAGUES AND 1472 00:58:38,248 --> 00:58:41,217 CONGRATULATING OTHERS ON THEIR 1473 00:58:41,284 --> 00:58:41,684 ROLES. 1474 00:58:41,751 --> 00:58:43,519 NOW LET'S SHIFT GEARS TO CREATE 1475 00:58:43,586 --> 00:58:46,923 A CULTURE OF CONTINUOUS 1476 00:58:46,990 --> 00:58:47,924 INNOVATION. 1477 00:58:47,991 --> 00:58:49,025 FOCUS ON CONTINUOUS INNOVATION 1478 00:58:49,092 --> 00:58:50,994 SHOWS COMMITMENT TO PIVOT FROM 1479 00:58:51,060 --> 00:58:52,896 INNOVATION AS ACTIVITY OR ACTION 1480 00:58:52,962 --> 00:58:55,365 TO CONTINUOUS MODEL THAT 1481 00:58:55,431 --> 00:58:56,799 ADVANCES MISSION, TESTS 1482 00:58:56,866 --> 00:58:57,901 STRATEGIES AND GARNERS BUDGET 1483 00:58:57,967 --> 00:58:59,402 AND RESOURCES WHILE WE MOVE TO 1484 00:58:59,469 --> 00:59:00,403 THE FUTURE. 1485 00:59:00,470 --> 00:59:02,605 IN DOING SO WE CAN ENABLE THE 1486 00:59:02,672 --> 00:59:04,474 IMPLEMENTATION OF NEW IDEAS, 1487 00:59:04,540 --> 00:59:06,342 SOLUTIONS, APPROACHES WHERE 1488 00:59:06,409 --> 00:59:08,778 INNOVATION REMAINS AN ELEMENT TO 1489 00:59:08,845 --> 00:59:13,082 OUR STRATEGY AND IDENTITY, THE 1490 00:59:13,149 --> 00:59:15,752 COMMITMENT MEETS A TOP PRIORITY 1491 00:59:15,818 --> 00:59:17,387 FOR NLM LEADERSHIP TEAM. 1492 00:59:17,453 --> 00:59:19,222 WE CONTINUE TO MAKE PROGRESS IN 1493 00:59:19,289 --> 00:59:21,858 ESTABLISHING A FORWARD LOOKING 1494 00:59:21,925 --> 00:59:23,059 MODEL OF INVASION APPLIED ACROSS 1495 00:59:23,126 --> 00:59:24,494 THE NLM. 1496 00:59:24,560 --> 00:59:25,929 THIS PIVOTS FROM INNOVATION AS A 1497 00:59:25,995 --> 00:59:27,664 SEPARATE SET OF ACTIONS TO 1498 00:59:27,730 --> 00:59:29,966 CONTINUOUS MODEL THAT IS 1499 00:59:30,033 --> 00:59:30,833 INTENTIONAL, CONSISTENT, 1500 00:59:30,900 --> 00:59:32,135 EMBEDDED ACROSS ALL LEVELS OF 1501 00:59:32,201 --> 00:59:33,236 THE ORGANIZATION. 1502 00:59:33,303 --> 00:59:35,338 SINCE JUNE 23, WE HAVE SELECTED 1503 00:59:35,405 --> 00:59:36,873 KEY COMPONENTS OF INNOVATION 1504 00:59:36,940 --> 00:59:39,375 REQUIRED TO CREATE OUR CULTURE 1505 00:59:39,442 --> 00:59:42,111 OF CONTINUOUS INNOVATION, ASSESS 1506 00:59:42,178 --> 00:59:44,681 AGAINST EACH COMPONENT, FIND 1507 00:59:44,747 --> 00:59:46,849 FUTURE STATE LEADERSHIP VISION, 1508 00:59:46,916 --> 00:59:47,650 DEVELOP A ROADMAP. 1509 00:59:47,717 --> 00:59:50,386 WITH THE FIRST STEPS OF 1510 00:59:50,453 --> 00:59:51,888 VISIONING COMPLETE IN 2024 WE 1511 00:59:51,955 --> 00:59:53,723 STARTED TO BUILD EACH ASPECT OF 1512 00:59:53,790 --> 00:59:55,124 THE CONTINUOUS INNOVATION MODEL. 1513 00:59:55,191 --> 00:59:56,259 TODAY WE'VE DEFINED A SHARED 1514 00:59:56,326 --> 00:59:59,228 VISION FOR THE FOUR MAJOR 1515 00:59:59,295 --> 01:00:02,465 COMPONENTS THAT INCLUDE 1516 01:00:02,532 --> 01:00:07,170 GOVERNANCE, IDEA LIFE CYCLE, 1517 01:00:07,236 --> 01:00:10,239 DEPLOYMENT AND MEASUREMENT, 1518 01:00:10,306 --> 01:00:12,542 ORGANIZATIONAL READINESS, WITH 1519 01:00:12,608 --> 01:00:13,176 KEY ACTIVITIES CONTINUING INTO 1520 01:00:13,242 --> 01:00:15,244 FISCAL 25. 1521 01:00:15,311 --> 01:00:21,084 THIS MODEL IS INTEGRAL TO 1522 01:00:21,150 --> 01:00:23,152 SUCCESS OF IMPLEMENTING SUCCESS 1523 01:00:23,219 --> 01:00:25,355 OF FOUR MAJOR COMPONENTS I JUST 1524 01:00:25,421 --> 01:00:25,855 REVIEWED. 1525 01:00:25,922 --> 01:00:27,390 GOVERNANCE IS ESSENTIAL AS THE 1526 01:00:27,457 --> 01:00:29,292 NLM LEADERSHIP TEAM WORKS TO SET 1527 01:00:29,359 --> 01:00:31,894 STANDARDS FOR DECISION MAKING 1528 01:00:31,961 --> 01:00:34,931 AND BUDGET ALLOCATION, 1529 01:00:34,998 --> 01:00:36,933 INNOVATION INVESTMENTS. 1530 01:00:37,000 --> 01:00:37,900 NEEDS IDENTIFICATION, IDEA 1531 01:00:37,967 --> 01:00:41,070 GENERATION, BUILD AND TEST AND 1532 01:00:41,137 --> 01:00:45,641 DESIGN AS WE BUILD END-TO-END 1533 01:00:45,708 --> 01:00:45,942 PROCESS. 1534 01:00:46,009 --> 01:00:47,243 THE ORGANIZATIONAL READINESS AND 1535 01:00:47,310 --> 01:00:48,644 DEPLOYMENT MEASUREMENT WILL 1536 01:00:48,711 --> 01:00:50,079 DRIVE CONTINUED REINFORCEMENT OF 1537 01:00:50,146 --> 01:00:52,348 THE MODEL ACROSS ALL LEVELS, 1538 01:00:52,415 --> 01:00:54,317 SENIOR LEADERS AND SUPERVISORS 1539 01:00:54,384 --> 01:00:56,085 AND STAFF. 1540 01:00:56,152 --> 01:00:57,420 DURING THE INITIAL VISIONING OF 1541 01:00:57,487 --> 01:00:58,154 THE CONTINUOUS INNOVATION 1542 01:00:58,221 --> 01:01:00,656 PROJECT WE CAME AWAY WITH FOUR 1543 01:01:00,723 --> 01:01:04,927 WORK STREAMS, EACH INTEGRAL TO 1544 01:01:04,994 --> 01:01:07,563 OUR GOALS, GOVERNANCE, IDEA LIFE 1545 01:01:07,630 --> 01:01:08,798 CYCLE, DEPLOYMENT MEASUREMENT 1546 01:01:08,865 --> 01:01:09,599 AND OPERATIONAL READY INSIDE, 1547 01:01:09,665 --> 01:01:12,702 THESE WILL BE FOUR WORK GROUPS 1548 01:01:12,769 --> 01:01:14,037 THAT WE'RE ESTABLISHING WITHIN 1549 01:01:14,103 --> 01:01:15,671 NLM THIS YEAR, AND THROUGH THE 1550 01:01:15,738 --> 01:01:17,240 REMAINDER OF THE FISCAL YEAR WE 1551 01:01:17,306 --> 01:01:19,175 WILL CONTINUE TO DEVELOP AND 1552 01:01:19,242 --> 01:01:20,910 TEST KEY COMPONENTS WITHIN 1553 01:01:20,977 --> 01:01:21,944 CONTINUOUS INNOVATION MODEL. 1554 01:01:22,011 --> 01:01:24,680 AS WE BUILD OUT WE'LL MAKE 1555 01:01:24,747 --> 01:01:25,715 REFINEMENTS AS NEEDED BASED ON 1556 01:01:25,782 --> 01:01:26,849 RECEIVED FEEDBACK. 1557 01:01:26,916 --> 01:01:27,850 THIS WILL RESULT IN 1558 01:01:27,917 --> 01:01:29,886 PRIORITIZATION OF NEXT STEPS TO 1559 01:01:29,952 --> 01:01:33,923 CONTINUE OUR PURSUITS INTO FY 25 1560 01:01:33,990 --> 01:01:34,590 AND BEYOND. 1561 01:01:34,657 --> 01:01:36,893 IT'S MY PLEASURE TO TURN OVER 1562 01:01:36,959 --> 01:01:41,497 THE MIC TO OUR ASSISTANT 1563 01:01:41,564 --> 01:01:45,435 DIRECTOR FOR POLICY DEVELOPMENT, 1564 01:01:45,501 --> 01:01:47,136 FOR AN UPDATE. 1565 01:01:47,203 --> 01:01:49,372 >> THANK YOU, STEPHEN. 1566 01:01:49,439 --> 01:01:50,206 GOOD MORNING. 1567 01:01:50,273 --> 01:01:52,642 I WANTED TO SHARE SOME BRIEF 1568 01:01:52,708 --> 01:02:03,052 POLICY AND LEGISLATIVE UPDATES. 1569 01:02:03,119 --> 01:02:04,387 FIRST SEVERAL POLICY ACTIVITIES 1570 01:02:04,454 --> 01:02:06,823 OF INTEREST TO NLM. 1571 01:02:06,889 --> 01:02:08,324 LATE LAST YEAR NATIONAL 1572 01:02:08,391 --> 01:02:10,693 ACADEMIES HOSTED A PUBLIC 1573 01:02:10,760 --> 01:02:14,130 WORKSHOP TO INFORM NIH AND 1574 01:02:14,197 --> 01:02:15,531 DEPARTMENT AGENCIES, POLICIES TO 1575 01:02:15,598 --> 01:02:17,867 ENHANCE PUBLIC ACCESS TO RESULTS 1576 01:02:17,934 --> 01:02:19,569 OF FEDERALLY FUNDED RESEARCH. 1577 01:02:19,635 --> 01:02:21,437 THE WORKSHOP DISCUSSIONS WILL BE 1578 01:02:21,504 --> 01:02:23,606 TAKEN INTO CONSIDERATION AS NIH 1579 01:02:23,673 --> 01:02:24,507 DEVELOPS UPDATED POLICY WHICH 1580 01:02:24,574 --> 01:02:25,842 WILL BE RELEASED FOR PUBLIC 1581 01:02:25,908 --> 01:02:27,810 COMMENT, WE'LL LOOK TO THE BOARD 1582 01:02:27,877 --> 01:02:32,014 TO HELP US DISSEMINATE THE DRAFT 1583 01:02:32,081 --> 01:02:33,149 ONCE RELEASED. 1584 01:02:33,216 --> 01:02:34,317 I WANTED TO HIGHLIGHT TWO KEY 1585 01:02:34,383 --> 01:02:36,018 ACTIVITIES BY THE OFFICE OF 1586 01:02:36,085 --> 01:02:38,087 NATIONAL COORDINATOR FOR HEALTH 1587 01:02:38,154 --> 01:02:39,388 INFORMATION TECHNOLOGY. 1588 01:02:39,455 --> 01:02:40,957 FIRST ON DECEMBER 3 THEY 1589 01:02:41,023 --> 01:02:46,195 RELEASED THE FINAL HEALTH DATA 1590 01:02:46,262 --> 01:02:47,830 TECHNOLOGY AND INTEROPERABILITY, 1591 01:02:47,897 --> 01:02:48,331 ALGORITHM TRANSPARENCY, 1592 01:02:48,397 --> 01:02:50,933 INFORMATION RULE. 1593 01:02:51,000 --> 01:02:51,567 WHICH IMPLEMENTS VISIONS OF THE 1594 01:02:51,634 --> 01:02:55,404 21ST CENTURY CURES ACT AND MAKES 1595 01:02:55,471 --> 01:02:57,573 UPDATES TO THE CERTIFICATION. 1596 01:02:57,640 --> 01:03:02,011 LAST MONTH RELEASED DRAFT 1597 01:03:02,078 --> 01:03:03,713 VERSION OF THE VERSION 5 OF U.S. 1598 01:03:03,779 --> 01:03:05,848 CORE DATA FOR PUBLIC COMMENT, 1599 01:03:05,915 --> 01:03:08,985 INCLUDING TWO NEW DATA CLASS, 13 1600 01:03:09,051 --> 01:03:10,953 NEW DATA ELEMENTS. 1601 01:03:11,020 --> 01:03:12,822 COMMENTS DUE BY APRIL 15. 1602 01:03:12,889 --> 01:03:16,859 ONC PLANS TO RELEASE THE FINAL 1603 01:03:16,926 --> 01:03:18,528 VERSION IN JULY. 1604 01:03:18,594 --> 01:03:21,497 WE CONTINUE TO MONITOR POLICY 1605 01:03:21,564 --> 01:03:22,398 ACTIVITY FOCUSED ON ARTIFICIAL 1606 01:03:22,465 --> 01:03:24,367 INTELLIGENCE, YOU MAY HAVE SEEN 1607 01:03:24,433 --> 01:03:27,370 THAT THE WHITE HOUSE RELEASED AN 1608 01:03:27,436 --> 01:03:29,405 EXECUTIVE ORDER FOCUSED ON A.I. 1609 01:03:29,472 --> 01:03:30,873 DEVELOPMENT AND USE. 1610 01:03:30,940 --> 01:03:31,908 SUBSEQUENT TO THAT, EARLY 1611 01:03:31,974 --> 01:03:34,810 NOVEMBER, THE OFFICE OF 1612 01:03:34,877 --> 01:03:36,779 MANAGEMENT AND BUDGET RELEASED 1613 01:03:36,846 --> 01:03:38,948 FOR PUBLIC COMMENT A DRAFT 1614 01:03:39,015 --> 01:03:47,390 POLICY FOR FEDERAL AGENCIES USE 1615 01:03:47,456 --> 01:03:47,657 . 1616 01:03:47,723 --> 01:03:50,459 AMERICAN MEDICAL ASSOCIATION AND 1617 01:03:50,526 --> 01:03:52,094 SUBSEQUENTLY AMERICAN MEDICAL 1618 01:03:52,161 --> 01:03:53,863 INFORMATICS ASSOCIATION RELEASED 1619 01:03:53,930 --> 01:03:55,498 POLICY BRIEF LATE LAST MONTH. 1620 01:03:55,565 --> 01:03:56,999 AS I MENTIONED IN SEPTEMBER 1621 01:03:57,066 --> 01:03:59,535 THERE'S ALSO GREAT INTEREST IN 1622 01:03:59,602 --> 01:04:00,570 A.I. IN CONGRESS, THERE HAVE 1623 01:04:00,636 --> 01:04:03,773 BEEN SIX A.I.-FOCUSED 1624 01:04:03,839 --> 01:04:05,775 CONGRESSIONAL HEARINGS SINCE OUR 1625 01:04:05,841 --> 01:04:08,911 LAST MEETING IN SEPTEMBER ON 1626 01:04:08,978 --> 01:04:09,378 WORKFORCE DEVELOPMENT, 1627 01:04:09,445 --> 01:04:13,416 PROCUREMENT, USE OF A.I. IN 1628 01:04:13,482 --> 01:04:14,083 GOVERNMENT, TRANSPARENCY AND 1629 01:04:14,150 --> 01:04:14,417 GOVERNANCE. 1630 01:04:14,483 --> 01:04:16,519 IN ADDITION SEVEN NEW BILLS HAVE 1631 01:04:16,586 --> 01:04:17,620 BEEN INTRODUCED SINCE WE LAST 1632 01:04:17,687 --> 01:04:20,890 MET FOR A TOTAL OF ABOUT 20 1633 01:04:20,957 --> 01:04:23,659 BILLS FOCUSED ON A.I. INTRODUCED 1634 01:04:23,726 --> 01:04:32,168 IN CONGRESS, FOCUSED ON RELATED 1635 01:04:32,235 --> 01:04:32,401 TOPICS. 1636 01:04:32,468 --> 01:04:33,836 AND THEN AS STEVE MENTIONED 1637 01:04:33,903 --> 01:04:37,006 WE'RE CONTINUING TO MONITOR 1638 01:04:37,073 --> 01:04:38,441 FISCAL YEAR 2024 APPROPRIATION 1639 01:04:38,507 --> 01:04:39,075 PROCESS. 1640 01:04:39,141 --> 01:04:42,011 IN ADDITION TO BEING UNDER 1641 01:04:42,078 --> 01:04:44,547 CONTINUING RESOLUTION THROUGH 1642 01:04:44,614 --> 01:04:46,949 MARCH 8, THE APPROPRIATORS 1643 01:04:47,016 --> 01:04:48,217 ANNOUNCED AGREEMENT ON 1644 01:04:48,284 --> 01:04:50,486 ALLOCATIONS FOR THE 12 1645 01:04:50,553 --> 01:04:51,020 APPROPRIATION COMMITTEES, 1646 01:04:51,087 --> 01:04:52,021 DETAILS NOT YET AVAILABLE. 1647 01:04:52,088 --> 01:04:53,723 WE'LL CONTINUE TO KEEP AN EYE ON 1648 01:04:53,789 --> 01:04:53,923 THAT. 1649 01:04:53,990 --> 01:04:55,558 WITH THAT I'LL TURN IT BACK OVER 1650 01:04:55,625 --> 01:04:57,460 TO STEVE. 1651 01:04:57,526 --> 01:04:57,827 >> THANK YOU. 1652 01:04:57,893 --> 01:04:58,761 WE HAVE APPROXIMATELY 15 MINUTES 1653 01:04:58,828 --> 01:05:02,164 TO OPEN THE FLOOR FOR 1654 01:05:02,231 --> 01:05:10,373 DISCUSSION. 1655 01:05:13,509 --> 01:05:17,747 >> MAYBE I'LL START THE 1656 01:05:17,813 --> 01:05:18,681 QUESTIONS. 1657 01:05:18,748 --> 01:05:21,017 STEVE, SO THE ITEM ABOUT 1658 01:05:21,083 --> 01:05:21,751 CONTINUOUS INNOVATION, I'M 1659 01:05:21,817 --> 01:05:23,419 WONDERING IF YOU CAN SHARE WITH 1660 01:05:23,486 --> 01:05:28,324 US A LITTLE BIT ABOUT HOW THAT'S 1661 01:05:28,391 --> 01:05:29,325 BEING SHARED AND COMMUNICATED 1662 01:05:29,392 --> 01:05:30,960 ACROSS NLM. 1663 01:05:31,027 --> 01:05:33,696 IT'S SUCH A LARGE ORGANIZATION, 1664 01:05:33,763 --> 01:05:36,732 WITH A BROAD MISSION, SO MANY 1665 01:05:36,799 --> 01:05:38,100 GREAT PEOPLE HELPING TO MAKE 1666 01:05:38,167 --> 01:05:42,038 THAT A REALITY. 1667 01:05:42,104 --> 01:05:44,073 I'M WONDERING, HOW THAT'S BEING 1668 01:05:44,140 --> 01:05:47,576 COMMUNICATED AND SUPPORTED IN 1669 01:05:47,643 --> 01:05:48,811 DIFFERENT WAYS. 1670 01:05:48,878 --> 01:05:49,312 >> GREAT QUESTION. 1671 01:05:49,378 --> 01:05:51,080 WE'RE AT THE BEGINNING OF THAT 1672 01:05:51,147 --> 01:05:52,281 PROCESS, I SHOULD SAY. 1673 01:05:52,348 --> 01:05:54,617 WHAT WE'VE DONE SO FAR HAS BEEN 1674 01:05:54,684 --> 01:05:55,685 EXECUTIVE LEADERSHIP AND 1675 01:05:55,751 --> 01:05:57,453 PLANNING. 1676 01:05:57,520 --> 01:05:58,854 WE'VE IDENTIFIED THE WORK 1677 01:05:58,921 --> 01:06:01,424 STREAMS IN FOUR AREAS, AND MY 1678 01:06:01,490 --> 01:06:02,591 UNDERSTANDING IS THAT THOSE WORK 1679 01:06:02,658 --> 01:06:05,361 GROUPS ARE GOING TO START 1680 01:06:05,428 --> 01:06:06,662 BRINGING IN SENIOR LEADERS 1681 01:06:06,729 --> 01:06:09,165 WITHIN EACH DIVISION, AND THAT 1682 01:06:09,231 --> 01:06:10,866 WILL START THIS CONVERSATION. 1683 01:06:10,933 --> 01:06:17,406 AND AS WE WORK DOWN THE ACTUAL 1684 01:06:17,473 --> 01:06:18,541 COMPOSITION AND TASK ASSIGNMENTS 1685 01:06:18,607 --> 01:06:21,077 WITHIN EACH GROUP THEY WILL THEN 1686 01:06:21,143 --> 01:06:24,046 BE READ OUT TO SUPERVISORS AND 1687 01:06:24,113 --> 01:06:28,784 TRAINEES, I THINK THE BASIC 1688 01:06:28,851 --> 01:06:30,886 IDEA, KIND OF LUCY-GOOSY TERMS, 1689 01:06:30,953 --> 01:06:32,288 WE'RE TRYING TO CREATE INCUBATOR 1690 01:06:32,355 --> 01:06:34,457 FOR INNOVATION THAT ALL 1691 01:06:34,523 --> 01:06:35,658 DIVISIONS CAN CONTRIBUTE IDEAS 1692 01:06:35,725 --> 01:06:37,860 TO AND GET SOME COACHING HOW TO 1693 01:06:37,927 --> 01:06:40,563 PITCH THE IDEAS AND BRING THEM 1694 01:06:40,629 --> 01:06:42,765 UP FOR ASSESSMENT AND EVALUATION 1695 01:06:42,832 --> 01:06:45,201 FOR LIKELIHOOD OF SUCCESS, 1696 01:06:45,267 --> 01:06:48,771 IMPACT, AND VALUE TO THE 1697 01:06:48,838 --> 01:06:49,905 ORGANIZATION. 1698 01:06:49,972 --> 01:06:52,007 AND THEN THIS INNOVATION 1699 01:06:52,074 --> 01:06:54,410 INCUBATING SPACE WILL THEN BRING 1700 01:06:54,477 --> 01:06:57,413 FORWARD SUCCESSFUL PROPOSALS TO 1701 01:06:57,480 --> 01:06:58,514 SENIOR LEADERSHIP AND FUND IN 1702 01:06:58,581 --> 01:06:59,382 THE BUDGET. 1703 01:06:59,448 --> 01:07:00,783 THAT'S ALL THE WORK OF THE NEXT 1704 01:07:00,850 --> 01:07:04,520 I THINK SIX MONTHS TO PILOT 1705 01:07:04,587 --> 01:07:06,288 THAT THIS YEAR SO WE HAVE ALL 1706 01:07:06,355 --> 01:07:07,156 PARTS. 1707 01:07:07,223 --> 01:07:10,192 HOW DO WE SOLICIT IDEAS, MENTOR 1708 01:07:10,259 --> 01:07:11,861 AND DEVELOP IDEA PROPOSERS TO 1709 01:07:11,927 --> 01:07:13,896 HAVE STRONG APPLICATIONS, HOW DO 1710 01:07:13,963 --> 01:07:16,332 WE DO THE INCUBATION 1711 01:07:16,399 --> 01:07:18,901 ASSESSMENTS, VET IDEAS, HOW DO 1712 01:07:18,968 --> 01:07:20,102 WE BRING THEM FORWARD IN FINAL 1713 01:07:20,169 --> 01:07:20,770 DECISION MAKING. 1714 01:07:20,836 --> 01:07:22,271 THERE'S WORK AT ALL LEVELS, 1715 01:07:22,338 --> 01:07:24,206 AGAIN THIS IS STILL IN THE 1716 01:07:24,273 --> 01:07:25,174 CONCEPT DEVELOPMENT PHASE, AND 1717 01:07:25,241 --> 01:07:27,410 MORE TO COME I THINK AT OUR NEXT 1718 01:07:27,476 --> 01:07:28,444 BOARD MEETING. 1719 01:07:28,511 --> 01:07:29,378 WE'LL HAVE SOME EXCITING UPDATES 1720 01:07:29,445 --> 01:07:31,680 ON HOW FAR WE'VE GOTTEN IN THE 1721 01:07:31,747 --> 01:07:31,981 PROCESS. 1722 01:07:32,047 --> 01:07:32,314 >> OKAY. 1723 01:07:32,381 --> 01:07:32,715 WONDERFUL. 1724 01:07:32,782 --> 01:07:37,353 THANK YOU SO MUCH. 1725 01:07:37,420 --> 01:07:38,487 THAT'S VERY EXCITING. 1726 01:07:38,554 --> 01:07:39,588 NANCY, GO AHEAD. 1727 01:07:39,655 --> 01:07:40,856 >> THANKS FOR THE UPDATES. 1728 01:07:40,923 --> 01:07:42,324 THAT WAS REALLY INTERESTING AND 1729 01:07:42,391 --> 01:07:42,792 HELPFUL. 1730 01:07:42,858 --> 01:07:48,197 I DO HAVE A QUESTION ALSO ON THE 1731 01:07:48,264 --> 01:07:49,498 CONTINUOUS INNOVATION 1732 01:07:49,565 --> 01:07:50,299 COMPONENTS. 1733 01:07:50,366 --> 01:07:51,600 MAYBE THIS QUESTION IS PREMATURE 1734 01:07:51,667 --> 01:07:55,538 BUT AS YOU'RE WORKING IN THOSE 1735 01:07:55,604 --> 01:07:57,206 FOUR WORK STREAMS, I ASSUME THAT 1736 01:07:57,273 --> 01:08:00,676 ONE OF THE NEXT STEPS IS 1737 01:08:00,743 --> 01:08:01,777 ESTABLISH TIMELINES AND YOUR 1738 01:08:01,844 --> 01:08:02,278 GOALS FOR THOSE. 1739 01:08:02,344 --> 01:08:04,947 BUT DO YOU HAVE AREAS OF FOCUS 1740 01:08:05,014 --> 01:08:07,917 OF OUTCOMES THAT YOU'RE GOING TO 1741 01:08:07,983 --> 01:08:10,019 ENCOURAGE IN INNOVATION SPACE? 1742 01:08:10,085 --> 01:08:11,854 ARE THERE PARTICULARLY WITH 1743 01:08:11,921 --> 01:08:16,358 RESPECT TO ONE OF THE NIH VISION 1744 01:08:16,425 --> 01:08:19,762 PRINCIPLES ABOUT THE RAPIDLY 1745 01:08:19,829 --> 01:08:20,863 ADAPTING DISCOVERIES INTO 1746 01:08:20,930 --> 01:08:21,931 CLINICAL CARE, SO ARE THERE 1747 01:08:21,997 --> 01:08:23,032 PARTICULAR AREAS THAT YOU'RE 1748 01:08:23,098 --> 01:08:25,534 GOING TO TRY TO EMPHASIZE IN 1749 01:08:25,601 --> 01:08:27,436 THOSE INNOVATION WORK STREAMS? 1750 01:08:27,503 --> 01:08:32,341 >> SO, I THINK THE CALL FOR 1751 01:08:32,408 --> 01:08:33,509 INNOVATION CERTAINLY WILL 1752 01:08:33,576 --> 01:08:35,711 PRIORITIZE THE INNOVATION, OR 1753 01:08:35,778 --> 01:08:39,815 THE STRATEGIC PRIORITIES, OF 1754 01:08:39,882 --> 01:08:40,015 NLM. 1755 01:08:40,082 --> 01:08:41,617 WE HAVE SOME SPECIFIC REQUESTS I 1756 01:08:41,684 --> 01:08:43,385 THINK FROM THE NIH DIRECTOR 1757 01:08:43,452 --> 01:08:46,455 ABOUT NEW WORK THAT WE COULD BE 1758 01:08:46,522 --> 01:08:48,424 DOING TO MODEL A NEW ROLE FOR 1759 01:08:48,491 --> 01:08:51,494 NLM, SO AROUND THE DATA 1760 01:08:51,560 --> 01:08:52,895 ECOSYSTEM ESPECIALLY, HOW WE 1761 01:08:52,962 --> 01:08:54,730 WOULD BE DOING REPRESENTATION 1762 01:08:54,797 --> 01:08:56,298 AND CATALOGING REMOTE DATA 1763 01:08:56,365 --> 01:08:57,633 ELEMENTS, WHAT GOVERNANCE LOOKS 1764 01:08:57,700 --> 01:08:58,968 LIKE IN THAT SPACE. 1765 01:08:59,034 --> 01:09:03,072 I THINK THERE COULD BE SOME VERY 1766 01:09:03,138 --> 01:09:08,644 STRONG OPPORTUNITIES TO DO SOME 1767 01:09:08,711 --> 01:09:09,778 PILOT INNOVATION WORK. 1768 01:09:09,845 --> 01:09:13,816 WE'RE TRYING TO EVOLVE THIS BOTH 1769 01:09:13,883 --> 01:09:14,550 AS AN INTERNAL INSTITUTE 1770 01:09:14,617 --> 01:09:17,653 METHODISM TO MAKE SURE THAT OUR 1771 01:09:17,720 --> 01:09:18,954 INNOVATION CAPACITY IS BROADLY 1772 01:09:19,021 --> 01:09:21,023 ACCESSIBLE TO ALL PARTS OF THE 1773 01:09:21,090 --> 01:09:22,858 STAFF, ALL UNITS OF THE LIBRARY, 1774 01:09:22,925 --> 01:09:25,194 NOT JUST IN A FEW OPERATIONAL 1775 01:09:25,261 --> 01:09:25,594 DIVISIONS. 1776 01:09:25,661 --> 01:09:28,898 AND THEY WOULD THEN IN TURN BE I 1777 01:09:28,964 --> 01:09:32,401 THINK APPLYING THIS TO THE 1778 01:09:32,468 --> 01:09:35,471 PRINCIPAL IN CHARGE, IN OUR 1779 01:09:35,538 --> 01:09:36,372 STRATEGIC PLAN WHAT OUR VISION 1780 01:09:36,438 --> 01:09:38,407 IS DIRECTING US TO DO. 1781 01:09:38,474 --> 01:09:40,276 THAT BEING SAID, I THINK THERE'S 1782 01:09:40,342 --> 01:09:41,243 PROBABLY A LIMITED AMOUNT WE CAN 1783 01:09:41,310 --> 01:09:44,113 DO THIS YEAR. 1784 01:09:44,179 --> 01:09:50,553 WE HAVE A MODEST BUDGET FOR 1785 01:09:50,619 --> 01:09:51,687 PILOTING THIS, AND I THINK WE 1786 01:09:51,754 --> 01:09:53,556 CAN'T BE MORE DEFINITIVE UNTIL 1787 01:09:53,622 --> 01:09:54,857 THE BUDGET IS SOLVED AND WE KNOW 1788 01:09:54,924 --> 01:09:56,392 THE FINAL NUMBERS WE'RE WORKING 1789 01:09:56,458 --> 01:09:57,826 WITH. 1790 01:09:57,893 --> 01:10:01,330 THAT'S WHERE WE CAN START DOING 1791 01:10:01,397 --> 01:10:03,098 CALL FOR APPLICATION. 1792 01:10:03,165 --> 01:10:03,399 >> THANKS. 1793 01:10:03,465 --> 01:10:05,000 >> DID THAT HELP? 1794 01:10:05,067 --> 01:10:13,642 >> THANKS VERY MUCH. 1795 01:10:22,651 --> 01:10:33,228 >> ARE THERE OTHER QUESTIONS OR 1796 01:10:34,430 --> 01:10:34,563 COMMENTS? 1797 01:10:34,630 --> 01:10:35,297 YES, COLONEL AZAD. 1798 01:10:35,364 --> 01:10:37,600 >> I WANT TO SAY THANK YOU FOR 1799 01:10:37,666 --> 01:10:40,035 BEING ON THE FOREFRONT OF, YOU 1800 01:10:40,102 --> 01:10:42,338 KNOW, LEADING INNOVATION, AND 1801 01:10:42,404 --> 01:10:43,305 JUST ONE QUICK QUESTION. 1802 01:10:43,372 --> 01:10:49,745 AS FAR AS THE C.R. GOES, HOW 1803 01:10:49,812 --> 01:10:51,080 DOES THAT AFFECT THE NATIONAL 1804 01:10:51,146 --> 01:10:53,849 INSTITUTE OF LIBRARIES, JUST 1805 01:10:53,916 --> 01:10:59,054 KIND OF A QUESTION. 1806 01:10:59,121 --> 01:11:00,689 >> WELL, STRICT ANSWER, IT 1807 01:11:00,756 --> 01:11:01,023 DEPENDS IF. 1808 01:11:01,090 --> 01:11:03,459 C.R. ENDS AND WE GET A BUDGET TO 1809 01:11:03,525 --> 01:11:05,160 FINISH THE YEAR UNDER A BUDGET 1810 01:11:05,227 --> 01:11:07,630 OR DO WE FINISH THE YEAR UNDER A 1811 01:11:07,696 --> 01:11:08,530 C.R. 1812 01:11:08,597 --> 01:11:10,666 IF YOU'RE UNDER C.R. YOU CANNOT 1813 01:11:10,733 --> 01:11:12,868 TAKE UP NEW ACTIVITIES OR 1814 01:11:12,935 --> 01:11:14,036 PROGRAMS, A LIMITING DEVICE. 1815 01:11:14,103 --> 01:11:15,804 WE'RE HOPEFUL WE'LL GET A BUDGET 1816 01:11:15,871 --> 01:11:16,271 PASSED. 1817 01:11:16,338 --> 01:11:17,539 THAT DOES OPEN THE OPPORTUNITY 1818 01:11:17,606 --> 01:11:18,974 FOR US TO DEVELOP NEW PROGRAMS 1819 01:11:19,041 --> 01:11:20,109 AND PRIORITIES. 1820 01:11:20,175 --> 01:11:21,810 THAT'S THE BIG CHANGE. 1821 01:11:21,877 --> 01:11:24,346 RIGHT NOW THE BUDGET LEVEL AND 1822 01:11:24,413 --> 01:11:25,914 THE C.R. BASICALLY THE C.R. 1823 01:11:25,981 --> 01:11:27,650 CARRIES YOU AT LAST YEAR'S 1824 01:11:27,716 --> 01:11:27,983 LEVEL. 1825 01:11:28,050 --> 01:11:29,718 LOOKS LIKE THE BUDGET IS LAST 1826 01:11:29,785 --> 01:11:30,152 YEAR'S LEVEL. 1827 01:11:30,219 --> 01:11:31,020 FINANCIALLY THEY ARE ABOUT THE 1828 01:11:31,086 --> 01:11:32,755 SAME BUT I THINK THE DIFFERENCES 1829 01:11:32,821 --> 01:11:34,523 WILL BE IN THE AUTHORITY AND 1830 01:11:34,590 --> 01:11:36,392 WHAT WE CAN DO IN THE REMAINING 1831 01:11:36,458 --> 01:11:38,027 HALF OF THE YEAR. 1832 01:11:38,093 --> 01:11:39,561 HOPEFULLY IT WILL BE IMPACTFUL 1833 01:11:39,628 --> 01:11:42,398 AND THAT WE'LL GET A BUDGET SOON 1834 01:11:42,464 --> 01:11:47,336 AND CAN EXECUTE SOME OF THIS NEW 1835 01:11:47,403 --> 01:11:54,543 WORK. 1836 01:11:54,610 --> 01:11:55,644 >> OKAY, THANK YOU. 1837 01:11:55,711 --> 01:11:57,713 >> THANK YOU FOR THE UPDATE. 1838 01:11:57,780 --> 01:12:00,382 IT'S ALWAYS WONDERFUL TO HEAR 1839 01:12:00,449 --> 01:12:05,387 NLM IS THIS INCREDIBLE SOURCE OF 1840 01:12:05,454 --> 01:12:06,121 DEPENDABLE EQUITABLE AND 1841 01:12:06,188 --> 01:12:07,856 ACCESSIBLE INFORMATION AND THAT 1842 01:12:07,923 --> 01:12:10,559 IS ALWAYS HELD WITH THIS SPIRIT 1843 01:12:10,626 --> 01:12:11,560 OF INNOVATION, AND REALLY 1844 01:12:11,627 --> 01:12:12,995 PUSHING THE BOUNDS AND BEING A 1845 01:12:13,062 --> 01:12:14,063 LEADER IN THIS SPACE. 1846 01:12:14,129 --> 01:12:17,433 IT'S WONDERFUL TO SEE THAT. 1847 01:12:17,499 --> 01:12:19,535 THANK YOU. 1848 01:12:19,601 --> 01:12:22,638 SO, EVERYONE, YOU'RE SEEING 1849 01:12:22,705 --> 01:12:24,106 WORKING GROUP BREAKOUT WINDOWS 1850 01:12:24,173 --> 01:12:24,840 POP UP. 1851 01:12:24,907 --> 01:12:26,842 PLEASE DON'T JOIN UNTIL AFTER MY 1852 01:12:26,909 --> 01:12:27,176 COMMENTS. 1853 01:12:27,242 --> 01:12:29,912 AND THEN WE'LL GO AHEAD TO OUR 1854 01:12:29,978 --> 01:12:30,312 BREAKOUTS. 1855 01:12:30,379 --> 01:12:31,914 FIRST OF ALL, I WANT TO NOTE A 1856 01:12:31,980 --> 01:12:32,848 COUPLE DISCUSSION POINTS BEFORE 1857 01:12:32,915 --> 01:12:35,918 WE MOVE INTO THESE BREAKOUT 1858 01:12:35,984 --> 01:12:36,452 DISCUSSIONS. 1859 01:12:36,518 --> 01:12:38,921 YOU'LL SEE PUBLIC SERVICES AND 1860 01:12:38,987 --> 01:12:40,322 COLLECTIONS ARE AGAIN COMBINED, 1861 01:12:40,389 --> 01:12:41,023 IN ADDITION TO REGULAR 1862 01:12:41,090 --> 01:12:42,725 DISCUSSION ITEMS THERE WILL BE 1863 01:12:42,791 --> 01:12:45,227 AN OPPORTUNITY TO DISCUSS THE 1864 01:12:45,294 --> 01:12:47,096 STRUCTURE AND CHARGE OF THESE 1865 01:12:47,162 --> 01:12:48,630 WORKING GROUPS. 1866 01:12:48,697 --> 01:12:50,265 AND HOW COLLECTION, WHATEVER 1867 01:12:50,332 --> 01:12:52,968 FORM THESE RESOURCES MAY TAKE, 1868 01:12:53,035 --> 01:12:56,171 AND PUBLIC SERVICES CAN BE 1869 01:12:56,238 --> 01:12:58,140 MEANINGFUL AS POSSIBLE. 1870 01:12:58,207 --> 01:12:59,675 NEXT RESEARCH FRONTIERS WORKING 1871 01:12:59,742 --> 01:13:01,844 GROUP WILL FOLLOW A PATH WITH 1872 01:13:01,910 --> 01:13:02,478 DISCUSSION ITEMS AND OPPORTUNITY 1873 01:13:02,544 --> 01:13:05,247 TO BEGIN DISCUSSION OF THE 1874 01:13:05,314 --> 01:13:09,852 RESEARCH FRONTIERS CHARGE, 1875 01:13:09,918 --> 01:13:14,656 CONSIDERING QUICKLY EVOLVING 1876 01:13:14,723 --> 01:13:15,491 RESEARCH PLANNED LANDSCAPE. 1877 01:13:15,557 --> 01:13:17,893 THIS LEADS US TO THE STRATEGIC 1878 01:13:17,960 --> 01:13:20,596 PLAN PLANNING WORKING GROUP, 1879 01:13:20,662 --> 01:13:23,699 STRATEGY IN ACTION IS A CONSTANT 1880 01:13:23,766 --> 01:13:25,367 FOCUS, WITH MUCH TO DISCUSS. 1881 01:13:25,434 --> 01:13:27,035 SO THANK YOU VERY MUCH FOR OUR 1882 01:13:27,102 --> 01:13:30,239 FIRST SESSION. 1883 01:13:30,305 --> 01:13:33,408 WE'LL MOVE INTO BREAKOUT ROOMS 1884 01:13:33,475 --> 01:13:35,377 >> WELCOME BACK, EVERYONE. 1885 01:13:35,444 --> 01:13:37,346 THANK YOU VERY MUCH FOR A GREAT 1886 01:13:37,412 --> 01:13:38,547 DISCUSSION IN THE WORKING 1887 01:13:38,614 --> 01:13:38,781 GROUPS. 1888 01:13:38,847 --> 01:13:43,352 IT'S NOW TIME FOR US TO HOLD 1889 01:13:43,418 --> 01:13:44,887 WORKING GROUP REPORTS. 1890 01:13:44,953 --> 01:13:49,491 AND SO, I WILL GO AHEAD AND JUST 1891 01:13:49,558 --> 01:13:51,894 WORK IN THE DIRECTION THAT I 1892 01:13:51,960 --> 01:13:54,163 PRESENTED THEM BEFORE WE LEFT 1893 01:13:54,229 --> 01:13:56,932 AND START WITH THE COMBINED 1894 01:13:56,999 --> 01:13:59,101 PUBLIC SERVICES AND COLLECTIONS 1895 01:13:59,168 --> 01:13:59,334 GROUP. 1896 01:13:59,401 --> 01:14:02,471 SO, PAUL, I THINK THAT IS YOU. 1897 01:14:02,538 --> 01:14:03,138 THANK YOU. 1898 01:14:03,205 --> 01:14:03,906 >> ALL RIGHT. 1899 01:14:03,972 --> 01:14:08,310 THANK YOU VERY MUCH, CHRISTY. 1900 01:14:08,377 --> 01:14:12,347 THANK YOU FOR THE NOTES, KRISTI 1901 01:14:12,414 --> 01:14:12,781 AND DIANE. 1902 01:14:12,848 --> 01:14:14,016 I'VE GOT A SUMMARY OF WHAT WE 1903 01:14:14,082 --> 01:14:18,620 TALKED ABOUT IN THE WORKING 1904 01:14:18,687 --> 01:14:21,590 GROUP, WE HAD FIVE AREAS WE 1905 01:14:21,657 --> 01:14:23,559 RECEIVED BRIEFINGS OR HAD 1906 01:14:23,625 --> 01:14:24,860 CONVERSATIONS ABOUT. 1907 01:14:24,927 --> 01:14:27,162 ONE WAS THE USER SERVICES AND 1908 01:14:27,229 --> 01:14:27,729 COLLECTION DIVISION 1909 01:14:27,796 --> 01:14:28,397 REORGANIZATION, WHICH I'LL TALK 1910 01:14:28,463 --> 01:14:29,998 ABOUT IN A MOMENT. 1911 01:14:30,065 --> 01:14:34,603 SECOND WAS AN UPDATE ON THE 1912 01:14:34,670 --> 01:14:35,237 COMPARATIVE GENOMICS RESOURCE 1913 01:14:35,304 --> 01:14:36,471 ACTIVITIES, CGR. 1914 01:14:36,538 --> 01:14:41,944 THE THIRD WAS UPDATE ON CLINICAL 1915 01:14:42,010 --> 01:14:42,945 TRIALS.COM, MY OBSERVATION OF 1916 01:14:43,011 --> 01:14:48,083 THE WORK IN THAT SPACE, AND WE 1917 01:14:48,150 --> 01:14:49,818 HAD A PRESENTATION, DATASET 1918 01:14:49,885 --> 01:14:54,723 CATALOG, AND FINALLY WE TALKED 1919 01:14:54,790 --> 01:14:56,391 ABOUT THE COLLECTION DEVELOPMENT 1920 01:14:56,458 --> 01:14:58,460 GUIDELINES UPDATES THAT HAVE 1921 01:14:58,527 --> 01:14:58,727 OCCURRED. 1922 01:14:58,794 --> 01:15:07,769 I WANT TO GIVE A SHOUT OUT AND 1923 01:15:07,836 --> 01:15:09,104 THANKS. 1924 01:15:09,171 --> 01:15:14,776 WHEN DIANE PRESENTED FOR PETER, 1925 01:15:14,843 --> 01:15:16,612 AND MARGARET McGEE TALKED 1926 01:15:16,678 --> 01:15:18,714 ABOUT COLLECTIONS FEES AS I 1927 01:15:18,780 --> 01:15:20,816 MENTIONED, FIRST ITEM WAS UPDATE 1928 01:15:20,883 --> 01:15:23,652 ON USER SERVICES AND COLLECTION 1929 01:15:23,719 --> 01:15:25,354 DIVISION TRANSITION THAT HAS 1930 01:15:25,420 --> 01:15:25,621 OCCURRED. 1931 01:15:25,687 --> 01:15:28,423 THIS IS PART OF THE 1932 01:15:28,490 --> 01:15:31,994 REORGANIZATION THAT COMES OUT OF 1933 01:15:32,060 --> 01:15:35,597 THE STRATEGIC PLAN FOR NLM, 1934 01:15:35,664 --> 01:15:37,232 2020-2036 FOR THE LIBRARY 1935 01:15:37,299 --> 01:15:44,740 SERVICES, NOW USER SERVICES AND 1936 01:15:44,806 --> 01:15:45,374 COLLECTION DIVISION. 1937 01:15:45,440 --> 01:15:49,444 IT'S A DIVISION WITH A SERIES OF 1938 01:15:49,511 --> 01:15:50,279 BRANCH, A DIFFERENT 1939 01:15:50,345 --> 01:15:52,180 ORGANIZATIONAL STRUCTURE THAN 1940 01:15:52,247 --> 01:15:52,848 BEFORE. 1941 01:15:52,915 --> 01:15:56,985 WITHIN ARE FIVE LONG-RANGE 1942 01:15:57,052 --> 01:15:59,154 GOALS, FIRST IS CREATE 1943 01:15:59,221 --> 01:15:59,922 MODERNIZED STRUCTURE FOCUSED ON 1944 01:15:59,988 --> 01:16:01,456 FUNCTIONS THAT NEED TO OCCUR 1945 01:16:01,523 --> 01:16:02,691 WITHIN THE ORGANIZATION, AND 1946 01:16:02,758 --> 01:16:05,827 THAT HAS BEEN ACCOMPLISHED. 1947 01:16:05,894 --> 01:16:07,362 THE OTHER FOUR LONG-RANGE 1948 01:16:07,429 --> 01:16:10,565 PLANNING GOALS HAD TO DO WITH 1949 01:16:10,632 --> 01:16:15,037 UNIFYING COLLECTIONS, SO AS TO 1950 01:16:15,103 --> 01:16:15,570 BRING TOGETHER DISPARATE 1951 01:16:15,637 --> 01:16:18,073 MATERIALS WITHIN THE COLLECTION 1952 01:16:18,140 --> 01:16:22,711 ITSELF, IN A MORE ACCESSIBLE 1953 01:16:22,778 --> 01:16:23,779 USER-ORIENTED WAY. 1954 01:16:23,845 --> 01:16:25,514 THE THIRD GOAL IS TO SUPPORT AND 1955 01:16:25,580 --> 01:16:28,150 PROMOTE THE USE OF HEALTH DATA 1956 01:16:28,216 --> 01:16:32,020 STANDARDS AND TERMINOLOGIES, AS 1957 01:16:32,087 --> 01:16:34,356 PART OF THAT REORGANIZATION 1958 01:16:34,423 --> 01:16:35,657 DIANE DESCRIBED A NEW BRANCH TO 1959 01:16:35,724 --> 01:16:37,359 FOCUS ON THAT AND TALKED ABOUT 1960 01:16:37,426 --> 01:16:39,594 HIRING THAT'S GOING TO BE 1961 01:16:39,661 --> 01:16:42,965 OCCURRING TO STAFF UP THAT 1962 01:16:43,031 --> 01:16:43,298 ORGANIZATION. 1963 01:16:43,365 --> 01:16:46,501 HAD A GOOD CONVERSATION ABOUT 1964 01:16:46,568 --> 01:16:52,941 THE WORK THAT IS THE FOURTH GOAL 1965 01:16:53,008 --> 01:16:56,912 OF THE REORGANIZATION PROVIDING 1966 01:16:56,979 --> 01:16:59,081 CUSTOMER SERVICE SUPPORT, USER 1967 01:16:59,147 --> 01:17:00,282 EXPERIENCE INTERFACE ACTIVITIES 1968 01:17:00,349 --> 01:17:01,717 WITH DIFFERENT PLATFORMS MADE 1969 01:17:01,783 --> 01:17:04,019 AVAILABLE THROUGH THE DIVISION. 1970 01:17:04,086 --> 01:17:06,855 AND THEN THE FIFTH GOAL IS 1971 01:17:06,922 --> 01:17:08,757 KNOWING AND ENGAGING OUR USERS, 1972 01:17:08,824 --> 01:17:12,361 THINKING MORE CREATIVELY OR 1973 01:17:12,427 --> 01:17:18,500 DIFFERENTLY HOW TO DO THAT GOING 1974 01:17:18,567 --> 01:17:18,734 FORWARD. 1975 01:17:18,800 --> 01:17:21,336 THIS REORGANIZATION SOMES OUT OF 1976 01:17:21,403 --> 01:17:22,437 THE LIBRARY SERVICES 15-YEAR 1977 01:17:22,504 --> 01:17:25,073 STRATEGIC PLAN THAT WAS KICKED 1978 01:17:25,140 --> 01:17:28,877 OFF IN 2020, REALIZED IN 2036, 1979 01:17:28,944 --> 01:17:32,614 AT THE 200th ANNIVERSARY OF 1980 01:17:32,681 --> 01:17:32,814 NLM. 1981 01:17:32,881 --> 01:17:35,784 AFTER THAT SESSION WE HAD A 1982 01:17:35,851 --> 01:17:37,753 PRESENTATION ON ALL THE 1983 01:17:37,819 --> 01:17:40,922 DIFFERENT ACTIVITIES WITHIN THE 1984 01:17:40,989 --> 01:17:43,959 COMPARATIVE GENOMICS RESOURCE 1985 01:17:44,026 --> 01:17:45,727 ACTIVITY AT NLM. 1986 01:17:45,794 --> 01:17:47,162 TERRENCE MURPHY GAVE A GREAT 1987 01:17:47,229 --> 01:17:48,797 OVERVIEW OF DIFFERENT ACTIVITIES 1988 01:17:48,864 --> 01:17:49,998 IN THAT SPACE, PARTICULARLY 1989 01:17:50,065 --> 01:17:54,302 AROUND THE WORK THAT WAS DONE AT 1990 01:17:54,369 --> 01:17:55,971 THE MEETING OF THE CGR WORKING 1991 01:17:56,038 --> 01:17:58,473 GROUP, AND JUST A LITTLE BIT OF 1992 01:17:58,540 --> 01:18:00,142 BACKGROUND, WHAT THE WORKING 1993 01:18:00,208 --> 01:18:02,310 GROUP IS TRYING TO DO OR IS 1994 01:18:02,377 --> 01:18:04,413 WORKING TO DO IS TO BRING 1995 01:18:04,479 --> 01:18:07,682 TOGETHER ALL THE DIFFERENT TOOLS 1996 01:18:07,749 --> 01:18:10,218 AND RESOURCES TO MAKE MORE 1997 01:18:10,285 --> 01:18:13,855 ACCESSIBLE ALL OF THE DIFFERENT 1998 01:18:13,922 --> 01:18:17,959 MODEL ORGANISMS, BUT BEYOND 1999 01:18:18,026 --> 01:18:19,294 MODEL ORGANISMS, EUKARYOTIC 2000 01:18:19,361 --> 01:18:22,230 ORGANISMS INTO A SYSTEM TO 2001 01:18:22,297 --> 01:18:23,498 FACILITATE GREATER ANALYSIS. 2002 01:18:23,565 --> 01:18:25,734 WHAT WAS -- WHAT OCCURRED AT THE 2003 01:18:25,801 --> 01:18:28,470 7th WORKING GROUP MEETING 2004 01:18:28,537 --> 01:18:29,171 WHICH TERRENCE TALKED THROUGH 2005 01:18:29,237 --> 01:18:31,339 WAS KIND OF AN UPDATE ON THE 2006 01:18:31,406 --> 01:18:33,175 DIFFERENT COMMUNICATIONS 2007 01:18:33,241 --> 01:18:34,709 ACTIVITIES ABOUT THE DIFFERENT 2008 01:18:34,776 --> 01:18:36,678 NCBI DATASETS AND DIFFERENT 2009 01:18:36,745 --> 01:18:38,780 ACTIVITIES WITHIN THE CGR KIND 2010 01:18:38,847 --> 01:18:39,915 OF WORKSPACE. 2011 01:18:39,981 --> 01:18:41,283 SOME TALK ABOUT DIFFERENT TYPES 2012 01:18:41,349 --> 01:18:43,552 OF WORKFLOWS AND USE CASES THAT 2013 01:18:43,618 --> 01:18:45,120 ARE GOING ON WITHIN THE 2014 01:18:45,187 --> 01:18:48,623 DIFFERENT COMMUNITIES THAT ARE 2015 01:18:48,690 --> 01:18:49,491 USING -- LEARNING ABOUT AND 2016 01:18:49,558 --> 01:18:51,460 BEGINNING TO USE THE RESOURCE. 2017 01:18:51,526 --> 01:18:56,932 AND THEN TALKED ABOUT WAYS TO 2018 01:18:56,998 --> 01:18:57,999 MAKE -- INCREASE AWARENESS. 2019 01:18:58,066 --> 01:19:03,171 THERE WAS A VERY ROBUST OUTWARD 2020 01:19:03,238 --> 01:19:03,905 FACING COMMUNICATION STRATEGY 2021 01:19:03,972 --> 01:19:07,876 WITH FOUR OR FIVE COMPONENTS TO 2022 01:19:07,943 --> 01:19:09,277 IT, AND GOOD PRESENTATION ON 2023 01:19:09,344 --> 01:19:13,014 TYPES OF OUTREACH AND THEIR 2024 01:19:13,081 --> 01:19:14,216 IMPACT, AND MORE DISCUSSION HOW 2025 01:19:14,282 --> 01:19:17,052 TO MAKE THAT WORK OCCUR GOING 2026 01:19:17,119 --> 01:19:18,720 FORWARD, AND REACHING OUT TO 2027 01:19:18,787 --> 01:19:21,890 DIFFERENT COMMUNITIES TO BRING 2028 01:19:21,957 --> 01:19:32,501 THEM INTO THE LARGER KIND OF CGR 2029 01:19:32,868 --> 01:19:33,001 ACTIVITY. 2030 01:19:33,068 --> 01:19:35,470 IT'S IF THE FOURTH YEAR OF WORK 2031 01:19:35,537 --> 01:19:37,205 WITH CGR. 2032 01:19:37,272 --> 01:19:39,040 THIRD PRESENTATION, NFI GAVE AN 2033 01:19:39,107 --> 01:19:42,244 UPDATE ON THE CLINICAL TRIALS 2034 01:19:42,310 --> 01:19:45,947 MODERNIZATION AND OVERVIEW, KIND 2035 01:19:46,014 --> 01:19:48,383 OF DESCRIBED HOW THEY ARE FLYING 2036 01:19:48,450 --> 01:19:49,951 A PLANE WHILE BUILDING A NEW 2037 01:19:50,018 --> 01:19:50,252 ONE. 2038 01:19:50,318 --> 01:19:53,755 IT WAS A REALLY GREAT ANALOGY TO 2039 01:19:53,822 --> 01:19:57,692 DESCRIBE WHAT'S GOING ON, PART 2040 01:19:57,759 --> 01:20:00,328 OF WHAT WAS DESCRIBED HOW THIS 2041 01:20:00,395 --> 01:20:02,297 IS -- SHE CAN CORRECT ME IF I 2042 01:20:02,364 --> 01:20:07,002 GET THIS NOT QUITE RIGHT BUT 2043 01:20:07,068 --> 01:20:11,139 TRANSITION FROM THE PREVIOUS 2044 01:20:11,206 --> 01:20:17,312 CLINICALTRIALS.COM TO MODERNIZED 2045 01:20:17,379 --> 01:20:18,713 CLINICALTRIALS.COM, BY I BELIEVE 2046 01:20:18,780 --> 01:20:21,116 THE SPRING OF THIS YEAR, AND THE 2047 01:20:21,183 --> 01:20:25,587 NOTION IS TO HAVE ALL 500,000 2048 01:20:25,654 --> 01:20:27,189 CLINICAL TRIALS AVAILABLE IN THE 2049 01:20:27,255 --> 01:20:27,923 MODERNIZED VERSION. 2050 01:20:27,989 --> 01:20:29,658 SHE HAD A GOOD CONVERSATION WITH 2051 01:20:29,724 --> 01:20:32,627 US ABOUT THE DIFFERENT TYPES OF 2052 01:20:32,694 --> 01:20:34,462 ACTIVITIES GOING ON WITH THAT 2053 01:20:34,529 --> 01:20:38,533 TRANSITION, AND THEN THE USER 2054 01:20:38,600 --> 01:20:41,069 ACTIVITY WITH THE NEW VERSION 2055 01:20:41,136 --> 01:20:42,704 VERSUS OLDER LEGACY VERSION. 2056 01:20:42,771 --> 01:20:45,774 THAT WAS A GOOD DEMONSTRATION OF 2057 01:20:45,840 --> 01:20:48,843 HOW THAT TRANSITION IS GOING, 2058 01:20:48,910 --> 01:20:50,378 SEEMINGLY GOING WELL, AND HOW 2059 01:20:50,445 --> 01:20:52,814 THEY ARE GETTING FEEDBACK ON HOW 2060 01:20:52,881 --> 01:20:55,850 THAT TRANSITION IS GOING. 2061 01:20:55,917 --> 01:21:00,121 ALSO HAD A PRESENTATION ON THE 2062 01:21:00,188 --> 01:21:01,656 AFFILIATED PROTOCOLS RESULT 2063 01:21:01,723 --> 01:21:08,763 SYSTEM, PRS, HOW THAT TRANSITION 2064 01:21:08,830 --> 01:21:10,932 IS TAKING PLACE AND TALKED WITH 2065 01:21:10,999 --> 01:21:13,268 TERRENCE ABOUT DIFFERENT 2066 01:21:13,335 --> 01:21:14,469 STRATEGIES AND ACTIVITIES THAT 2067 01:21:14,536 --> 01:21:17,072 THEY ARE PROMOTING, DEVELOPING 2068 01:21:17,138 --> 01:21:23,211 AND PROMOTING, TO GET TECHNICAL 2069 01:21:23,278 --> 01:21:24,846 INFORMATION OUT TO THE DIFFERENT 2070 01:21:24,913 --> 01:21:27,148 CONSUMERS OF THIS, YOU KNOW, THE 2071 01:21:27,215 --> 01:21:28,883 CLINICAL TRIALS PLATFORM AS 2072 01:21:28,950 --> 01:21:32,153 TRANSITION OCCURS IN THE 2073 01:21:32,220 --> 01:21:33,922 PROTOCOLS PLATFORM, AS THAT 2074 01:21:33,989 --> 01:21:37,525 TRANSITION OCCURS, ON SOCIAL 2075 01:21:37,592 --> 01:21:38,960 MEDIA, LISTSERVs, DIFFERENT 2076 01:21:39,027 --> 01:21:41,129 MEETINGS AND WEBERS IN FOR 2077 01:21:41,196 --> 01:21:41,896 DETAILED PRESENTATION, REALLY 2078 01:21:41,963 --> 01:21:45,000 GOOD REVIEW OF ALL THOSE 2079 01:21:45,066 --> 01:21:48,169 DIFFERENT MODERNIZATION 2080 01:21:48,236 --> 01:21:48,570 ACTIVITIES. 2081 01:21:48,637 --> 01:21:53,008 NEXT WE HAD A PRESENTATION ON 2082 01:21:53,074 --> 01:21:55,176 THE DATASET CATALOG, AS DIANE 2083 01:21:55,243 --> 01:21:59,014 DESCRIBED IT, THE PubMed OF 2084 01:21:59,080 --> 01:21:59,481 DATASETS. 2085 01:21:59,547 --> 01:22:02,517 AND SOME OF THIS WE'RE TESTING 2086 01:22:02,584 --> 01:22:05,120 OUT THE APPLICATION, THE BETA 2087 01:22:05,186 --> 01:22:06,321 APPLICATION, AS DIANE WAS 2088 01:22:06,388 --> 01:22:12,460 DESCRIBING IT TOES. 2089 01:22:12,527 --> 01:22:13,528 TO US. 2090 01:22:13,595 --> 01:22:16,064 SHE WENT OVER KIND OF WHAT THIS 2091 01:22:16,131 --> 01:22:20,001 TRANSITION IS AND HOW THEY ARE 2092 01:22:20,068 --> 01:22:21,903 CONNECTING BACK THROUGH HARVEST, 2093 01:22:21,970 --> 01:22:23,271 I BELIEVE TO FOUR OR FIVE 2094 01:22:23,338 --> 01:22:28,310 DIFFERENT OTHER TYPES OF 2095 01:22:28,376 --> 01:22:32,480 REPOSITORIES TO MAKE THESE 2096 01:22:32,547 --> 01:22:34,582 CONNECTIONS, DRYAD, HARVARD'S 2097 01:22:34,649 --> 01:22:37,385 DATA VERSE, IMPORT, SOME OTHER 2098 01:22:37,452 --> 01:22:38,720 PRODUCTS, SO TALK A LITTLE BIT 2099 01:22:38,787 --> 01:22:44,125 ABOUT THAT ACTIVITY AND THEN THE 2100 01:22:44,192 --> 01:22:44,693 MITIGATED MODELING PROTOCOL 2101 01:22:44,759 --> 01:22:51,900 WHICH I THINK STEVE MENTIONED 2102 01:22:51,966 --> 01:22:53,101 EARLIER IN HIS PRESENTATION, 2103 01:22:53,168 --> 01:22:54,636 LAUNCHED ON THE 23RD OF JANUARY, 2104 01:22:54,703 --> 01:22:57,939 A NUMBER OF US HAVE BEEN POKING 2105 01:22:58,006 --> 01:22:58,573 AROUND THROUGH OUR CONNECTIONS 2106 01:22:58,640 --> 01:23:00,008 WITHIN NLM. 2107 01:23:00,075 --> 01:23:01,209 IT'S GOOD TO HEAR MORE ABOUT 2108 01:23:01,276 --> 01:23:03,878 THIS ACTIVITY AND BE ABLE TO 2109 01:23:03,945 --> 01:23:07,549 TAKE IT OUT FOR A RIDE. 2110 01:23:07,615 --> 01:23:09,884 DIANE TALKED ABOUT HOW THERE 2111 01:23:09,951 --> 01:23:11,286 ALREADY MORE OPPORTUNITIES TO 2112 01:23:11,353 --> 01:23:14,556 GATHER FEEDBACK THAT NLM WILL BE 2113 01:23:14,622 --> 01:23:16,891 GATHERING FEEDBACK IN A WEBINAR 2114 01:23:16,958 --> 01:23:18,193 SEMINAR KIND OF OFFICE-HOURS 2115 01:23:18,259 --> 01:23:20,161 ACTIVITY ON THE 11th OF APRIL, 2116 01:23:20,228 --> 01:23:21,696 AND WAS REALLY INTERESTED IN 2117 01:23:21,763 --> 01:23:25,867 HEARING MORE FROM US AS WE 2118 01:23:25,934 --> 01:23:28,703 GATHER MORE EXPERIENCE IN USING 2119 01:23:28,770 --> 01:23:30,538 THE TOOL, PROVIDE SOME FEEDBACK 2120 01:23:30,605 --> 01:23:33,174 WITH BETA VERSION SO THEY CAN 2121 01:23:33,241 --> 01:23:33,842 MOVE WITH THIS PRODUCT 2122 01:23:33,908 --> 01:23:35,477 DEVELOPMENT AS THEY HAVE WITH 2123 01:23:35,543 --> 01:23:38,446 THE OTHER PRODUCTS THAT THEY ARE 2124 01:23:38,513 --> 01:23:39,414 ALSO DEVELOPING. 2125 01:23:39,481 --> 01:23:42,784 THE FINAL AREA THAT WE HAD A 2126 01:23:42,851 --> 01:23:44,886 PRESENTATION ON WAS FROM 2127 01:23:44,953 --> 01:23:47,389 MARGARET McGEE ABOUT 2128 01:23:47,455 --> 01:23:49,924 COLLECTION DEVELOPMENT GUIDELINE 2129 01:23:49,991 --> 01:23:50,592 UPDATE. 2130 01:23:50,658 --> 01:23:52,660 MARGARET TALKED ABOUT THREE 2131 01:23:52,727 --> 01:23:56,464 DIFFERENT AREAS THAT NLM HAS 2132 01:23:56,531 --> 01:23:57,465 TAKEN FROM OUR WORKING GROUP 2133 01:23:57,532 --> 01:24:01,236 BACK TO THE COLLECTION 2134 01:24:01,302 --> 01:24:04,172 DEVELOPMENT GUIDELINES, FOCUSED 2135 01:24:04,239 --> 01:24:05,673 ON THE DATASET, BEING ABLE TO 2136 01:24:05,740 --> 01:24:08,977 MAKE SURE DATASETS ARE PART OF 2137 01:24:09,043 --> 01:24:10,278 THE GUIDELINES, DATASET 2138 01:24:10,345 --> 01:24:13,548 GUIDELINES. 2139 01:24:13,615 --> 01:24:13,848 PRE-PRINTS. 2140 01:24:13,915 --> 01:24:16,518 AND THEN ALSO NLM RETENTION 2141 01:24:16,584 --> 01:24:18,920 POLICY FOR OTHER KINDS OF 2142 01:24:18,987 --> 01:24:19,788 MATERIALS PARTICULARLY FROM 2143 01:24:19,854 --> 01:24:20,688 PUBLIC HEALTH EMERGENCIES AND 2144 01:24:20,755 --> 01:24:24,893 HOW TO BE ABLE TO MANAGE OF 2145 01:24:24,959 --> 01:24:27,662 DISPOSITION OF THOSE OVER THE 2146 01:24:27,729 --> 01:24:28,563 LONGER TERM. 2147 01:24:28,630 --> 01:24:30,532 MARGARET GAVE A GREAT OVERVIEW 2148 01:24:30,598 --> 01:24:33,368 OF THE COLLECTION DEVELOPMENT 2149 01:24:33,435 --> 01:24:34,803 POLICY INTERACTS WITH GUIDELINES 2150 01:24:34,869 --> 01:24:37,539 NLM CARRIES OUT, INTERACTION 2151 01:24:37,605 --> 01:24:38,873 BETWEEN OUR WORKING GROUP AND 2152 01:24:38,940 --> 01:24:40,442 THE BORED OF REGENTS, PROVIDING 2153 01:24:40,508 --> 01:24:42,377 FEEDBACK HOW THAT GETS 2154 01:24:42,444 --> 01:24:42,977 INCORPORATED INTO GUIDELINES, 2155 01:24:43,044 --> 01:24:44,212 WHEN THERE ARE MAJOR CHANGES 2156 01:24:44,279 --> 01:24:46,314 THAT NEED TO BE MADE WITH POLICY 2157 01:24:46,381 --> 01:24:47,682 ITSELF, THINGS THAT HAD TO BE 2158 01:24:47,749 --> 01:24:49,851 DONE LIKE EVERY, YOU KNOW, TEN 2159 01:24:49,918 --> 01:24:52,654 YEARS OR SO, HOW THAT PIECE 2160 01:24:52,720 --> 01:24:53,621 WORKS TOGETHER. 2161 01:24:53,688 --> 01:24:56,090 I SEE DIANE IS POSTING DIFFERENT 2162 01:24:56,157 --> 01:24:58,259 COMMENTS IN THE CHAT COVERING 2163 01:24:58,326 --> 01:25:01,396 DIFFERENT ITEMS I THINK I'VE 2164 01:25:01,463 --> 01:25:02,931 BEEN COVERING. 2165 01:25:02,997 --> 01:25:05,433 I'D LIKE TO NOW SAY, MY 2166 01:25:05,500 --> 01:25:08,136 COLLEAGUES ON THE WORKING GROUP, 2167 01:25:08,203 --> 01:25:11,172 CONGRATULATIONS TO PRESENTERS ON 2168 01:25:11,239 --> 01:25:13,374 OUTSTANDING WORK ON DIFFERENT 2169 01:25:13,441 --> 01:25:14,776 PLAN, THE PROGRESS THAT'S BEEN 2170 01:25:14,843 --> 01:25:16,311 MADE WITH THE PLATFORMS, THEN 2171 01:25:16,377 --> 01:25:18,947 WITH THE POLICY ITSELF. 2172 01:25:19,013 --> 01:25:20,782 AND THEN THANKS TO MY COLLEAGUES 2173 01:25:20,849 --> 01:25:24,953 ON THE WORKING GROUP. 2174 01:25:25,019 --> 01:25:27,021 WE HAD A RICH DISCUSSION, AND 2175 01:25:27,088 --> 01:25:28,556 WOULD HAVE BEEN RICHER AND GONE 2176 01:25:28,623 --> 01:25:30,124 ON FOR TWO MORE HOURS IF WE 2177 01:25:30,191 --> 01:25:32,026 DIDN'T GO TO LUNCH. 2178 01:25:32,093 --> 01:25:34,496 BUT THERE WAS CONVERSATION HOW 2179 01:25:34,562 --> 01:25:37,632 GENERATIVE A.I. CAN BE 2180 01:25:37,699 --> 01:25:38,733 APPLIED -- WHAT ARE NLM'S 2181 01:25:38,800 --> 01:25:40,702 THOUGHTS ABOUT THAT, AND DIANE 2182 01:25:40,768 --> 01:25:42,904 TALKED ABOUT SOME TEN USE CASES 2183 01:25:42,971 --> 01:25:48,610 THAT STEVE PRESENTED EARLIER IN 2184 01:25:48,676 --> 01:25:51,246 HIS NLM OVERVIEW. 2185 01:25:51,312 --> 01:25:55,717 WE HAD SOME IDEAS FOR YUX THINGS 2186 01:25:55,783 --> 01:25:57,785 WITH THE DATASET CATALOG AND HAD 2187 01:25:57,852 --> 01:25:59,654 SOME CONVERSATIONS ABOUT 2188 01:25:59,721 --> 01:26:05,360 LEARNING MORE ABOUT WHAT NLM AND 2189 01:26:05,426 --> 01:26:07,662 NIH ARE DOING WITH SECURE 2190 01:26:07,729 --> 01:26:08,630 GENERATIVE A.I. ENVIRONMENTS, WE 2191 01:26:08,696 --> 01:26:10,598 COULD ALSO FIGURE OUT HOW TO 2192 01:26:10,665 --> 01:26:12,133 MAKE USE CASES WORK ON, THOSE 2193 01:26:12,200 --> 01:26:13,468 WERE THE THREE BIG AREAS. 2194 01:26:13,535 --> 01:26:16,304 LIKE I SAID, WE COULD HAVE 2195 01:26:16,371 --> 01:26:18,172 COVERED ANOTHER TEN IF GIVEN 2196 01:26:18,239 --> 01:26:18,473 TIME. 2197 01:26:18,540 --> 01:26:20,141 SO CONGRATULATIONS AND THANKS 2198 01:26:20,208 --> 01:26:21,809 FOR THE OPPORTUNITY. 2199 01:26:21,876 --> 01:26:23,878 IF ANYONE ELSE WANTS TO CHIME IN 2200 01:26:23,945 --> 01:26:33,821 THAT WOULD BE GREAT TOO. 2201 01:26:33,888 --> 01:26:35,356 >> THANKS, PAUL. 2202 01:26:35,423 --> 01:26:36,591 THAT WAS WONDERFUL, A RICH 2203 01:26:36,658 --> 01:26:36,891 DISCUSSION. 2204 01:26:36,958 --> 01:26:38,293 YOU'RE RIGHT, WE COULD HAVE GONE 2205 01:26:38,359 --> 01:26:38,993 FOR HOURS. 2206 01:26:39,060 --> 01:26:39,761 IT WAS WONDERFUL. 2207 01:26:39,827 --> 01:26:40,728 THANK YOU. 2208 01:26:40,795 --> 01:26:44,566 EYE LIKE TO WELCOME SOMEONE FROM 2209 01:26:44,632 --> 01:26:46,000 THE RESEARCH FRONTIERS BREAKOUT 2210 01:26:46,067 --> 01:26:50,038 GROUP TO GIVE A REPORT-OUT 2211 01:26:50,104 --> 01:26:50,371 PLEASE. 2212 01:26:50,438 --> 01:26:50,638 >> OKAY. 2213 01:26:50,705 --> 01:26:52,106 WELL, WE TOOK A VOTE AND DECIDED 2214 01:26:52,173 --> 01:26:54,309 I WOULD BE THE ONE TO GIVE THE 2215 01:26:54,375 --> 01:26:56,177 REPORT-OUT SINCE I WAS THE ONLY 2216 01:26:56,244 --> 01:26:58,913 REGENT IN THE MEETING. 2217 01:26:58,980 --> 01:27:01,849 OUR REPORT WILL BE 2218 01:27:01,916 --> 01:27:02,951 (INDISCERNIBLE), THE REPORT WE 2219 01:27:03,017 --> 01:27:04,819 HEARD BASED ON NUMBER OF 2220 01:27:04,886 --> 01:27:05,053 MEMBERS. 2221 01:27:05,119 --> 01:27:07,088 WE BASICALLY DISCUSSED ONE 2222 01:27:07,155 --> 01:27:09,057 TOPIC, WE WERE CHARGED, I WAS 2223 01:27:09,123 --> 01:27:11,793 CHARGED, WE WERE CHARGED WITH 2224 01:27:11,859 --> 01:27:14,329 DISCUSSING THE IDEA OF 2225 01:27:14,395 --> 01:27:16,631 REFORMULATING RESEARCH FRONTIERS 2226 01:27:16,698 --> 01:27:19,834 WORKING GROUP TO FOCUS ON RATHER 2227 01:27:19,901 --> 01:27:21,970 THAN ON FRONTIERS 2228 01:27:22,036 --> 01:27:23,538 RECOMMENDATIONS OF, YOU KNOW, 2229 01:27:23,605 --> 01:27:26,374 FUTURE DIRECTIONS WHICH ARE FOR 2230 01:27:26,441 --> 01:27:27,375 THE INTRAMURAL PROGRAM HANDLED 2231 01:27:27,442 --> 01:27:33,147 BY I GUESS THE BOARD OF 2232 01:27:33,214 --> 01:27:34,482 SCIENTIFIC COUNSELORS, AND EPI 2233 01:27:34,549 --> 01:27:34,816 SUBCOMMITTEE. 2234 01:27:34,882 --> 01:27:38,620 WE WERE ASKED TO PROVIDE 2235 01:27:38,686 --> 01:27:39,854 OVERSIGHT FOR NON-INTRAMURAL 2236 01:27:39,921 --> 01:27:41,456 RESEARCH PROGRAM PUBLIC 2237 01:27:41,522 --> 01:27:41,723 PRODUCTS. 2238 01:27:41,789 --> 01:27:45,526 AND THE IDEA WOULD BE THAT WE 2239 01:27:45,593 --> 01:27:47,829 WOULD PROVIDE ADVICE BASICALLY 2240 01:27:47,895 --> 01:27:50,131 ON DIRECTIONS AND NEEDS FOR 2241 01:27:50,198 --> 01:27:51,799 EXISTING PRODUCTS AND POSSIBLY 2242 01:27:51,866 --> 01:27:52,300 NEW PRODUCTS. 2243 01:27:52,367 --> 01:27:56,037 WE HAD A LIST OF EXAMPLES THAT, 2244 01:27:56,104 --> 01:27:58,439 YOU KNOW, PEOPLE WERE ADDING TO 2245 01:27:58,506 --> 01:28:00,908 THAT, I'M SURE WE COULD ADD 2246 01:28:00,975 --> 01:28:03,711 MORE, BUT LET ME READ THE LIST 2247 01:28:03,778 --> 01:28:08,082 PROVIDED BY NEW AND EXISTING 2248 01:28:08,149 --> 01:28:10,151 PUBLIC PRODUCTS, ADVICE ON 2249 01:28:10,218 --> 01:28:11,019 PRODUCTS, TECHNOLOGIES FOR NLM 2250 01:28:11,085 --> 01:28:12,754 TO CONSIDER DEVELOPING OR USING, 2251 01:28:12,820 --> 01:28:18,393 REPRESENTING NEEDS OF NLM 2252 01:28:18,459 --> 01:28:19,360 REGENTS STAKEHOLDERS TO BETTER 2253 01:28:19,427 --> 01:28:21,329 SERVE WITH PRODUCTS OR SERVICE, 2254 01:28:21,396 --> 01:28:23,097 PROVIDE ADVICE ON STANDARDS IN 2255 01:28:23,164 --> 01:28:27,902 SUPPORT OF PRODUCTS, NLM CREATED 2256 01:28:27,969 --> 01:28:29,771 UTILIZATION OF EXISTING 2257 01:28:29,837 --> 01:28:32,273 STANDARDS, KNOW ONTOLOGY, 2258 01:28:32,340 --> 01:28:34,609 SNOMED, ET CETERA, PROVIDE 2259 01:28:34,676 --> 01:28:35,576 ADVICE TO DISCONTINUE PRODUCTS. 2260 01:28:35,643 --> 01:28:37,211 WHAT WOULD BE KEY ELEMENTS TO 2261 01:28:37,278 --> 01:28:39,080 INCLUDE IN THE NEW CHARGE, WE 2262 01:28:39,147 --> 01:28:41,149 WOULD WORK WITH YOU TODAY AFTER 2263 01:28:41,215 --> 01:28:43,117 THE MEETING TO PREPARE NEW 2264 01:28:43,184 --> 01:28:43,785 CHARGE. 2265 01:28:43,851 --> 01:28:47,588 WE DECIDED TO EAT LUNCH INSTEAD 2266 01:28:47,655 --> 01:28:49,557 OF WORDSMITH, SO WE'LL GO BACK 2267 01:28:49,624 --> 01:28:55,496 AND FORTH AND MAKE IT A MORE 2268 01:28:55,563 --> 01:28:58,232 SUCCINCT STATEMENT AND WITH, YOU 2269 01:28:58,299 --> 01:29:00,401 KNOW, CLEAR NON-OVERLAPPING 2270 01:29:00,468 --> 01:29:01,269 EXAMPLES. 2271 01:29:01,335 --> 01:29:04,439 AND BUT THE IDEA BASICALLY TO 2272 01:29:04,505 --> 01:29:07,075 CHANGE THE FOCUS TO -- INSTEAD 2273 01:29:07,141 --> 01:29:10,244 OF FRONTIERS, SORT OF, YOU KNOW, 2274 01:29:10,311 --> 01:29:12,447 LOOKING BACK AT WHAT'S BEEN 2275 01:29:12,513 --> 01:29:14,449 ACCOMPLISHED AND WHAT CAN BE 2276 01:29:14,515 --> 01:29:16,284 PROMOTED FROM WITHIN. 2277 01:29:16,350 --> 01:29:17,952 SO, HAPPY TO TRY TO FIELD 2278 01:29:18,019 --> 01:29:28,396 QUESTIONS ABOUT THAT. 2279 01:29:31,466 --> 01:29:33,868 >> MAYBE I'LL ASK A QUESTION, 2280 01:29:33,935 --> 01:29:34,469 JIM. 2281 01:29:34,535 --> 01:29:36,971 I'M WONDERING WHEN YOU HAD THESE 2282 01:29:37,038 --> 01:29:38,072 CONVERSATIONS, YOU KNOW, 2283 01:29:38,139 --> 01:29:40,274 THINKING ABOUT THE FUTURE OF THE 2284 01:29:40,341 --> 01:29:42,910 GROUP AND THE DIRECTION THAT YOU 2285 01:29:42,977 --> 01:29:48,916 WANT TO TAKE, WERE THERE ANY 2286 01:29:48,983 --> 01:29:50,985 MAJOR LIKE THEMES OR -- OTHER 2287 01:29:51,052 --> 01:29:54,288 THAN WHAT YOU DISCUSSED IN TERMS 2288 01:29:54,355 --> 01:29:57,358 OF LIKE THE INTERESTED PARTIES 2289 01:29:57,425 --> 01:29:58,993 OR GROUPS, OR, YOU KNOW, 2290 01:29:59,060 --> 01:30:02,163 INDIVIDUALS TO KEEP IN MIND WITH 2291 01:30:02,230 --> 01:30:04,565 SOME OF THESE DISCUSSIONS. 2292 01:30:04,632 --> 01:30:06,601 >> WELL, ONLY TO SAY 2293 01:30:06,667 --> 01:30:07,735 CONSTITUENCIES OF INTEREST WOULD 2294 01:30:07,802 --> 01:30:12,607 BE BROAD, SO IT WOULD BE 2295 01:30:12,673 --> 01:30:13,708 CONSUMERS, RESEARCHERS, 2296 01:30:13,775 --> 01:30:14,142 PRACTITIONERS. 2297 01:30:14,208 --> 01:30:17,879 YOU KNOW, I THINK -- BUT WE 2298 01:30:17,945 --> 01:30:19,347 DIDN'T GET INTO SPECIFICS. 2299 01:30:19,413 --> 01:30:20,815 UNLESS SOMEBODY ELSE MIGHT HAVE 2300 01:30:20,882 --> 01:30:27,688 A DIFFERENT RECOLLECTION. 2301 01:30:27,755 --> 01:30:28,122 >> OKAY. 2302 01:30:28,189 --> 01:30:28,656 GREAT. 2303 01:30:28,723 --> 01:30:32,627 ANY OTHER QUESTIONS OR COMMENTS? 2304 01:30:32,693 --> 01:30:33,861 ALL RIGHT, WONDERFUL. 2305 01:30:33,928 --> 01:30:36,030 THANKS VERY MUCH. 2306 01:30:36,097 --> 01:30:37,565 OH, STEVE? 2307 01:30:37,632 --> 01:30:39,967 >> OH, WELL I WAS GOING TO SAY 2308 01:30:40,034 --> 01:30:41,736 THANKS, JIM, FOR THE REPORT-OUT 2309 01:30:41,803 --> 01:30:47,975 AND WORKING ON THIS. 2310 01:30:48,042 --> 01:30:49,410 OUR PRODUCTION SERVICES, ONE OF 2311 01:30:49,477 --> 01:30:50,611 THE CHALLENGES WE HAVE IS 2312 01:30:50,678 --> 01:30:52,680 FIGURING OUT IN THE KIND OF 2313 01:30:52,747 --> 01:30:54,448 CURRENT BUDGET ENVIRONMENT WHAT 2314 01:30:54,515 --> 01:30:56,284 SUSTAINABILITY LOOKS LIKE, HOW 2315 01:30:56,350 --> 01:30:57,819 TO PRIORITIZE, YOU KNOW, 2316 01:30:57,885 --> 01:31:00,121 SERVICES AND VALUE, AND MAKE 2317 01:31:00,188 --> 01:31:01,889 SURE THAT WE ARE STILL 2318 01:31:01,956 --> 01:31:03,491 POSITIONED TO DO TOMORROW'S 2319 01:31:03,558 --> 01:31:04,192 WORK, RIGHT? 2320 01:31:04,258 --> 01:31:06,260 AND SO THERE'S ALWAYS GOING TO 2321 01:31:06,327 --> 01:31:07,695 BE THIS, YOU KNOW, CHALLENGE 2322 01:31:07,762 --> 01:31:09,297 THAT YOU TALKED ABOUT SUNSETTING 2323 01:31:09,363 --> 01:31:11,632 A LITTLE BIT, I THINK THIS IS A 2324 01:31:11,699 --> 01:31:12,600 BIG CHALLENGE FOR NIH. 2325 01:31:12,667 --> 01:31:15,236 AND THIS IS AN AREA WHERE NIH 2326 01:31:15,303 --> 01:31:17,405 HAS ASKED FOR NLM TO OFFER 2327 01:31:17,471 --> 01:31:19,941 LEADERSHIP, HOW DO WE GRACEFULLY 2328 01:31:20,007 --> 01:31:21,242 SUNSET PRODUCTS THAT WERE 2329 01:31:21,309 --> 01:31:23,945 IMPORTANT BUT WE NEED TO, YOU 2330 01:31:24,011 --> 01:31:25,847 KNOW, RECAPTURE RESOURCES TO DO 2331 01:31:25,913 --> 01:31:26,614 TOMORROW'S OPPORTUNITY. 2332 01:31:26,681 --> 01:31:30,384 WHAT DOES THAT LOOK LIKE TO 2333 01:31:30,451 --> 01:31:31,652 DIMINISH THINGS. 2334 01:31:31,719 --> 01:31:33,154 AND SO, YOU KNOW, WE CAN'T BE 2335 01:31:33,221 --> 01:31:34,922 ALL THINGS TO ALL PEOPLE AND 2336 01:31:34,989 --> 01:31:36,557 EVER GROW ON LIMITED RESOURCES, 2337 01:31:36,624 --> 01:31:37,892 SO I LOOK FORWARD TO WORKING 2338 01:31:37,959 --> 01:31:39,093 WITH THIS WORKING GROUP AND 2339 01:31:39,160 --> 01:31:41,062 LEARNING KIND OF WHAT YOUR 2340 01:31:41,128 --> 01:31:42,463 THINKING IS, GUIDANCE WE CAN GET 2341 01:31:42,530 --> 01:31:46,300 IN THAT AREA AS WE TRY TO 2342 01:31:46,367 --> 01:31:47,168 FORMALIZE SOME SUNSETTING 2343 01:31:47,235 --> 01:31:47,835 PRINCIPLES. 2344 01:31:47,902 --> 01:31:52,006 LOOK FORWARD TO THAT, THANKS. 2345 01:31:52,073 --> 01:31:52,373 >> WONDERFUL. 2346 01:31:52,440 --> 01:31:54,175 THANKS VERY MUCH. 2347 01:31:54,242 --> 01:31:55,376 ALL RIGHT. 2348 01:31:55,443 --> 01:31:56,577 I'D LIKE TO INVITE A 2349 01:31:56,644 --> 01:31:58,346 REPRESENTATIVE FROM THE 2350 01:31:58,412 --> 01:31:59,447 STRATEGIC PLANNING BREAKOUT 2351 01:31:59,513 --> 01:32:04,986 GROUP TO GIVE A REPORT PLEASE. 2352 01:32:06,287 --> 01:32:09,523 >> IS THAT ME? 2353 01:32:09,590 --> 01:32:10,591 IS THAT ME? 2354 01:32:10,658 --> 01:32:11,192 >> YES. 2355 01:32:11,259 --> 01:32:14,362 I THINK THAT'S YOU. 2356 01:32:14,428 --> 01:32:14,896 >> OKAY. 2357 01:32:14,962 --> 01:32:16,931 SO SUSAN KIRSCH, FROM VETERANS 2358 01:32:16,998 --> 01:32:17,632 HEALTH ADMINISTRATION, 2359 01:32:17,698 --> 01:32:18,833 APPRECIATE THE OPPORTUNITY TO 2360 01:32:18,900 --> 01:32:21,269 JOIN THIS GROUP. 2361 01:32:21,335 --> 01:32:24,071 I'M PADDLING FAST TO CATCH UP ON 2362 01:32:24,138 --> 01:32:28,509 SOME OF THESE REALLY HONESTLY 2363 01:32:28,576 --> 01:32:29,810 FASCINATING AND APPLICABLE 2364 01:32:29,877 --> 01:32:31,646 EFFORTS THAT ARE MEANINGFUL IN 2365 01:32:31,712 --> 01:32:32,213 THE VETERANS HEALTH 2366 01:32:32,280 --> 01:32:33,981 ADMINISTRATION AS WELL. 2367 01:32:34,048 --> 01:32:35,383 SO, THE FIRST PRESENTATION THAT 2368 01:32:35,449 --> 01:32:39,553 WE HEARD WAS LEADING THE WAY TO 2369 01:32:39,620 --> 01:32:42,189 PUBLIC ACCESS TO PUBLICATION, 2370 01:32:42,256 --> 01:32:43,257 INTERAGENCY SUPPORTS NLM 2371 01:32:43,324 --> 01:32:50,231 STRATEGIC GOALS, ENABLES ACCESS 2372 01:32:50,298 --> 01:32:52,166 TO FEDERALLY FUNDED WORK. 2373 01:32:52,233 --> 01:32:54,669 THE GROUP ON PUBLICATIONS, UNDER 2374 01:32:54,735 --> 01:32:56,537 OSP AND WHITE HOUSE 2375 01:32:56,604 --> 01:32:58,172 SUBCOMMITTEE, AND SUBCOMMITTEE 2376 01:32:58,239 --> 01:32:59,707 OF OPEN SCIENCE, I DON'T KNOW 2377 01:32:59,774 --> 01:33:00,908 ALL THE ACRONYMS BUT I'M 2378 01:33:00,975 --> 01:33:02,777 FAMILIAR WITH SOME, AIMS TO 2379 01:33:02,843 --> 01:33:03,978 DEVELOP STRATEGIES, RESOURCES 2380 01:33:04,045 --> 01:33:06,180 AND TOOLS FOR MAXIMIZING PUBLIC 2381 01:33:06,247 --> 01:33:08,249 ACCESS TO FEDERALLY FUNDED 2382 01:33:08,316 --> 01:33:08,683 PUBLICATIONS. 2383 01:33:08,749 --> 01:33:09,684 I FOUND IT REALLY INTERESTING 2384 01:33:09,750 --> 01:33:11,953 THAT NLM HAS BEEN WORKING IN 2385 01:33:12,019 --> 01:33:14,388 THIS SPACE FOR YEARS, AND THAT 2386 01:33:14,455 --> 01:33:17,992 PMC IS THE SOLE REPOSITORY FOR 2387 01:33:18,059 --> 01:33:20,861 RESULTS OF THE NIH-FUNDED 2388 01:33:20,928 --> 01:33:21,228 RESEARCH. 2389 01:33:21,295 --> 01:33:22,930 AND ALSO, WORKS WITH AND 2390 01:33:22,997 --> 01:33:24,265 COLLABORATES WITH NINE OTHER 2391 01:33:24,332 --> 01:33:26,133 FEDERAL AGENCIES AND OTHER 2392 01:33:26,200 --> 01:33:27,969 FUNDERS, I THINK THE GATES 2393 01:33:28,035 --> 01:33:30,805 FOUNDATION WAS ONE OF THEM, THAT 2394 01:33:30,871 --> 01:33:31,572 LIST. 2395 01:33:31,639 --> 01:33:34,642 AND SO WHERE IS THIS SUBGROUP 2396 01:33:34,709 --> 01:33:35,109 GOING? 2397 01:33:35,176 --> 01:33:37,278 THERE'S AN ACTION PLAN THAT 2398 01:33:37,345 --> 01:33:40,781 FOCUSED ON PRIORITIES DRIVEN BY 2399 01:33:40,848 --> 01:33:44,518 THE 2022 OSTP PUBLIC ACCESS MEMO 2400 01:33:44,585 --> 01:33:45,586 ON ENSURING FREE EQUITABLE 2401 01:33:45,653 --> 01:33:47,254 ACCESS TO FEDERALLY FUNDED 2402 01:33:47,321 --> 01:33:47,521 RESEARCH. 2403 01:33:47,588 --> 01:33:50,524 KATIE HIGHLIGHTED A FEW 2404 01:33:50,591 --> 01:33:51,826 PRIORITIES OF THE PUBLICATION 2405 01:33:51,892 --> 01:33:53,194 WORKING GROUP ACTIONS. 2406 01:33:53,260 --> 01:33:55,997 SO ACTION NUMBER 2 ENABLING 2407 01:33:56,063 --> 01:33:57,531 MACHINE LEARNING IS APPLICABLE 2408 01:33:57,598 --> 01:33:59,400 IN THE CURRENT ENVIRONMENT AND 2409 01:33:59,467 --> 01:34:01,569 PROPOSED ACTION TO DEVELOP AND 2410 01:34:01,635 --> 01:34:03,771 PROMOTE STRATEGIES TO ENABLE 2411 01:34:03,838 --> 01:34:05,406 LARGE SCALE TEXT MINING AND 2412 01:34:05,473 --> 01:34:07,575 ANALYSIS OF FEDERALLY FUNDED 2413 01:34:07,641 --> 01:34:08,142 PUBLICATIONS. 2414 01:34:08,209 --> 01:34:09,777 I DON'T EXACTLY NOW PERSONALLY 2415 01:34:09,844 --> 01:34:12,513 HOW THIS WILL ALL WORK BUT I 2416 01:34:12,580 --> 01:34:14,482 THINK THAT IT WILL BE 2417 01:34:14,548 --> 01:34:16,117 INTERESTING TO UNDERSTAND HOW TO 2418 01:34:16,183 --> 01:34:19,520 USE A.I. AND M.L. TO ACCELERATE 2419 01:34:19,587 --> 01:34:23,357 THIS WORK, AND THEN NLM EXAMPLE 2420 01:34:23,424 --> 01:34:26,060 IS PMC ARTICLE DATASETS. 2421 01:34:26,127 --> 01:34:28,963 PMC OPEN ACCESS SUBSET HAS MORE 2422 01:34:29,030 --> 01:34:30,998 THAN 6 MILLION ACCESS ARTICLES, 2423 01:34:31,065 --> 01:34:32,867 FUNDAMENTALLY LOOKING FROM MY 2424 01:34:32,933 --> 01:34:37,805 OWN NOTES, HOW DO WE MAKE 2425 01:34:37,872 --> 01:34:39,106 PUBLICLY FUNDED RESEARCH MORE 2426 01:34:39,173 --> 01:34:40,207 AVAILABLE, I THINK THAT'S A GOAL 2427 01:34:40,274 --> 01:34:42,710 THAT I WROTE DOWN THAT RESONATED 2428 01:34:42,777 --> 01:34:44,812 WITH ME TO CONTINUE TO EXPAND 2429 01:34:44,879 --> 01:34:46,247 ACCESSIBILITY THERE. 2430 01:34:46,313 --> 01:34:49,417 THAT WAS IMPORTANT. 2431 01:34:49,483 --> 01:34:52,386 AND THEN ANOTHER BIG EFFORT WAS 2432 01:34:52,453 --> 01:34:54,121 EXPLORING ALTERNATIVES TO 2433 01:34:54,188 --> 01:34:55,790 JOURNAL ARTICLES TO SPEED 2434 01:34:55,856 --> 01:34:58,626 ACCESS, DEVELOP AND PROMOTE 2435 01:34:58,692 --> 01:35:01,262 STRATEGIES TO SUPPORT DISCOVERY 2436 01:35:01,328 --> 01:35:02,897 OF AGENCY RESEARCH PRODUCTS, 2437 01:35:02,963 --> 01:35:04,098 PRE-PRINT TECHNICAL REPORTS AND 2438 01:35:04,165 --> 01:35:05,199 OTHER GREAT LITERATURE WHICH IS 2439 01:35:05,266 --> 01:35:08,803 ALWAYS I THINK IN MY MIND 2440 01:35:08,869 --> 01:35:12,840 IMPORTANT TO BE PART OF 2441 01:35:12,907 --> 01:35:15,142 UNDERSTANDING ALL THAT WE DO 2442 01:35:15,209 --> 01:35:17,111 HAVE OUT THERE AND AVAILABLE AND 2443 01:35:17,178 --> 01:35:18,412 THAT WE'RE LEARNING FROM. 2444 01:35:18,479 --> 01:35:20,614 SO BEFORE KATIE JUMPS IN TO SAY 2445 01:35:20,681 --> 01:35:23,150 WHAT I DID MISS, I THINK THAT 2446 01:35:23,217 --> 01:35:25,986 I'LL END BY SAYING THESE EFFORTS 2447 01:35:26,053 --> 01:35:28,289 RESULT IN STRATEGIC ALIGNMENT 2448 01:35:28,355 --> 01:35:29,790 ACROSS FEDERAL AGENCIES AND 2449 01:35:29,857 --> 01:35:31,992 SUPPORT NLM GOALS AND OPENS UP 2450 01:35:32,059 --> 01:35:35,196 SPACE FOR NLM TO LEAD, SO I 2451 01:35:35,262 --> 01:35:40,534 CERTAINLY WAS NOT COMPREHENSIVE 2452 01:35:40,601 --> 01:35:42,303 HERE BUT HOPEFULLY KATIE OR 2453 01:35:42,369 --> 01:35:47,041 OTHERS THINK I HIT -- 2454 01:35:47,108 --> 01:35:48,209 >> YOU DID GREAT. 2455 01:35:48,275 --> 01:35:50,277 >> FAST TALKING TO GET IT ALL 2456 01:35:50,344 --> 01:35:50,478 IN. 2457 01:35:50,544 --> 01:35:53,848 I'LL PAUSE BEFORE I GO TO THE 2458 01:35:53,914 --> 01:35:54,648 NEXT ONE. 2459 01:35:54,715 --> 01:35:55,749 IS THAT OKAY? 2460 01:35:55,816 --> 01:36:01,889 OR YOU WANT ME TO DO BOTH? 2461 01:36:01,956 --> 01:36:03,524 >> I GUESS GO AHEAD AND COVER 2462 01:36:03,591 --> 01:36:05,526 BOTH AND THEN MIRIAM AND I CAN 2463 01:36:05,593 --> 01:36:07,261 TAG TEAM. 2464 01:36:07,328 --> 01:36:09,130 >> OKAY, PERFECT. 2465 01:36:09,196 --> 01:36:11,298 THIS ONE, MY PORTFOLIO IN 2466 01:36:11,365 --> 01:36:13,067 VETERANS HEALTH ADMINISTRATION 2467 01:36:13,134 --> 01:36:14,935 IS EXECUTIVE BRANCH OVERLAPS 2468 01:36:15,002 --> 01:36:16,570 RESEARCH AND DEVELOPMENT, AND IT 2469 01:36:16,637 --> 01:36:19,073 CURRENTLY A.I. IS IN OFFICE OF 2470 01:36:19,140 --> 01:36:20,508 RESEARCH AND DEVELOPMENT, AS 2471 01:36:20,574 --> 01:36:23,110 WELL AS INNOVATION AND HEALTH 2472 01:36:23,177 --> 01:36:25,179 PROFESSIONS TRAINING. 2473 01:36:25,246 --> 01:36:27,181 SO THIS WAS REALLY RESONATING 2474 01:36:27,248 --> 01:36:30,117 WITH ME, AND REALLY LEARNED FROM 2475 01:36:30,184 --> 01:36:31,652 MIRIAM IN THIS ABOUT, YOU KNOW, 2476 01:36:31,719 --> 01:36:33,220 MOVING FORWARD FROM A YEAR OF 2477 01:36:33,287 --> 01:36:35,589 OPEN SCIENCE TO A FUTURE FOR 2478 01:36:35,656 --> 01:36:38,526 OPEN EQUITABLE AND SECURE 2479 01:36:38,592 --> 01:36:40,094 RESEARCH OF OUR 9 MILLION 2480 01:36:40,161 --> 01:36:40,961 VETERAN POPULATION. 2481 01:36:41,028 --> 01:36:45,132 EQUITY IS SOMETHING WE THINK 2482 01:36:45,199 --> 01:36:46,967 ABOUT IN THIS RELATIVELY 2483 01:36:47,034 --> 01:36:47,635 UNDERSERVED POPULATION, SO A LOT 2484 01:36:47,701 --> 01:36:50,371 OF THIS MADE SENSE TO ME. 2485 01:36:50,437 --> 01:36:52,907 2023 WAS DESIGNATED THE YEAR OF 2486 01:36:52,973 --> 01:36:55,576 OPEN SCIENCE, BY THE WHITE HOUSE 2487 01:36:55,643 --> 01:36:57,678 OFFICE OF SCIENCE AND TECHNOLOGY 2488 01:36:57,745 --> 01:36:59,680 POLICY, OSTP. 2489 01:36:59,747 --> 01:37:01,549 17 AGENCIES AND OSTP 2490 01:37:01,615 --> 01:37:04,685 PARTICIPATED IN THE YEAR OF OPEN 2491 01:37:04,752 --> 01:37:06,253 SCIENCE, ACTIVITIES WERE 2492 01:37:06,320 --> 01:37:07,121 COORDINATED THROUGH INTERAGERY 2493 01:37:07,188 --> 01:37:09,089 YEAR OF OPEN SCIENCE SUBGROUP 2494 01:37:09,156 --> 01:37:12,259 WHICH EXPLORED ACTIVITIES AND 2495 01:37:12,326 --> 01:37:13,694 OPPORTUNITIES FOR COLLABORATION, 2496 01:37:13,761 --> 01:37:15,095 AND OFFICIAL GOVERNMENT 2497 01:37:15,162 --> 01:37:16,297 DEFINITION IS -- I THINK WE'RE 2498 01:37:16,363 --> 01:37:18,299 IN AN ENVIRONMENT WE WANT TO 2499 01:37:18,365 --> 01:37:19,700 MAKE SURE WE CLARIFY WHAT THIS 2500 01:37:19,767 --> 01:37:22,002 IS AND ISN'T, FOR THE GENERAL OR 2501 01:37:22,069 --> 01:37:25,072 MORE LAY FOLKS IN THIS AREA. 2502 01:37:25,139 --> 01:37:28,108 I'M STRUGGLING WITH THAT WITH 2503 01:37:28,175 --> 01:37:28,709 A.I. DEFINITIONS, CLINICIANS, 2504 01:37:28,776 --> 01:37:31,278 AND TO SAY THAT FOR OPEN SCIENCE 2505 01:37:31,345 --> 01:37:33,714 IT IS THE PRINCIPAL PRACTICE OF 2506 01:37:33,781 --> 01:37:35,883 MAKING RESEARCH PRODUCTS AND 2507 01:37:35,950 --> 01:37:41,455 PROCESSES AVAILABLE TO ALL WHILE 2508 01:37:41,522 --> 01:37:45,826 RESPECTING DIVERSE CULTURES, 2509 01:37:45,893 --> 01:37:46,827 FOSTERING COLLABORATION, EQUITY, 2510 01:37:46,894 --> 01:37:49,663 A DEFINITION FOR FOCUS AND IT 2511 01:37:49,730 --> 01:37:52,166 WAS VERY STRONG DEFINITION FROM 2512 01:37:52,233 --> 01:37:53,934 THIS PRESENTATION. 2513 01:37:54,001 --> 01:37:56,337 OPEN SCIENCE ALSO CUTS ACROSS 2514 01:37:56,403 --> 01:37:58,539 NLM'S MISSION AND STRATEGIC 2515 01:37:58,606 --> 01:37:59,306 PLAN. 2516 01:37:59,373 --> 01:38:01,809 THE GOALS OF NLM STRATEGIC PLAN 2517 01:38:01,875 --> 01:38:03,344 ARE REFLECTED THROUGHOUT THE 2518 01:38:03,410 --> 01:38:05,079 DEFINITION, MAKING RESEARCH 2519 01:38:05,145 --> 01:38:06,614 PRODUCTS AND PROCESSES SUCH AS 2520 01:38:06,680 --> 01:38:08,816 MAKING RESEARCH PRODUCTS AND 2521 01:38:08,882 --> 01:38:10,551 PROCESSES AVAILABLE, TO ALL, IS 2522 01:38:10,618 --> 01:38:14,255 ROOTED IN WHAT NLM DOES. 2523 01:38:14,321 --> 01:38:16,890 PubMed, PMC, 2524 01:38:16,957 --> 01:38:18,425 clinicaltrials.gov, AND MORE. 2525 01:38:18,492 --> 01:38:21,295 IN TERMS OF RESPECTING DIVERSE 2526 01:38:21,362 --> 01:38:23,564 CULTURES, NLM IS A POWERFUL WAY 2527 01:38:23,631 --> 01:38:24,865 TO CONNECT COMMUNITIES ACROSS 2528 01:38:24,932 --> 01:38:28,068 THE COUNTRY, PROVIDING 2529 01:38:28,135 --> 01:38:31,572 OPPORTUNITIES TO DISSEMINATE 2530 01:38:31,639 --> 01:38:33,307 INFO, FEEDBACK, MAINTAINING 2531 01:38:33,374 --> 01:38:34,942 SECURITY, PRIVACY IS ANOTHER 2532 01:38:35,009 --> 01:38:36,377 EXAMPLE NLM PROVIDES LEADERSHIP 2533 01:38:36,443 --> 01:38:38,012 AND INNOVATION INCLUDING 2534 01:38:38,078 --> 01:38:39,313 CONTROLLED ACCESS TO SENSITIVE 2535 01:38:39,380 --> 01:38:44,785 DATASETS, I DO NOT KNOW THIS 2536 01:38:44,852 --> 01:38:45,352 DATASET, DBGaP. 2537 01:38:45,419 --> 01:38:47,121 SO HOPEFULLY SOME OF YOU DO. 2538 01:38:47,187 --> 01:38:48,956 I WILL BE LEARNING. 2539 01:38:49,023 --> 01:38:53,227 BUT REALLY ALL OF THIS ALIGNS 2540 01:38:53,294 --> 01:38:54,762 AND FOSTERS COLLABORATIONS, 2541 01:38:54,828 --> 01:38:55,429 REPRODUCIBILITY, EQUITY, WHICH 2542 01:38:55,496 --> 01:38:57,331 IS THE PURPOSE AND VALUE ADD OF 2543 01:38:57,398 --> 01:38:58,232 OPEN SCIENCE. 2544 01:38:58,299 --> 01:39:00,668 SO THAT MADE A LOT OF SENSE TO 2545 01:39:00,734 --> 01:39:01,201 ME. 2546 01:39:01,268 --> 01:39:03,604 AND THAT ALIGNMENT WITH NLM 2547 01:39:03,671 --> 01:39:04,171 STRATEGIC PRIORITIES. 2548 01:39:04,238 --> 01:39:08,442 SO, WHAT I ALSO DID LEARN AND 2549 01:39:08,509 --> 01:39:09,977 THOUGHT WAS INTERESTING WAS 2550 01:39:10,044 --> 01:39:12,713 ABOUT THE DESIRE TO HAVE A 2551 01:39:12,780 --> 01:39:15,349 CONFERENCE THAT WILL BRING SOME 2552 01:39:15,416 --> 01:39:18,652 FOLKS TOGETHER, AND LEARN FROM 2553 01:39:18,719 --> 01:39:22,489 DIFFERENT TYPES OF LEADERS, BOTH 2554 01:39:22,556 --> 01:39:23,357 RESEARCHERS AND NON-RESEARCHERS, 2555 01:39:23,424 --> 01:39:25,659 AND IN A WAY TO CONTINUE TO 2556 01:39:25,726 --> 01:39:30,798 DEVELOP A WAY FORWARD FOR 2557 01:39:30,864 --> 01:39:32,333 EQUITABLE OPEN SCIENCE, TO 2558 01:39:32,399 --> 01:39:35,369 EXAMPLES, ONE WAS DEFICIT MODEL, 2559 01:39:35,436 --> 01:39:37,137 IDEA RESEARCHERS AND INFORMATION 2560 01:39:37,204 --> 01:39:38,639 PROFESSIONALS, THOSE WITH 2561 01:39:38,706 --> 01:39:40,841 SPECIAL ACCESS TO KNOWLEDGE AND 2562 01:39:40,908 --> 01:39:41,742 INFORMATION HAVE OPPORTUNITY TO 2563 01:39:41,809 --> 01:39:43,811 BESTOW INFORMATION UPON OTHERS. 2564 01:39:43,877 --> 01:39:45,346 THIS IS MORE UNIDIRECTIONAL. 2565 01:39:45,412 --> 01:39:46,747 WE ONLY MAKE OUTPUTS AVAILABLE 2566 01:39:46,814 --> 01:39:49,049 AT THE END OF THE RESEARCH LIFE 2567 01:39:49,116 --> 01:39:51,251 CYCLE, REALLY THROUGH A MEETING 2568 01:39:51,318 --> 01:39:53,887 AND COLLABORATION WITH THE 2569 01:39:53,954 --> 01:39:55,522 PARTICIPATION MODEL, MAYBE 2570 01:39:55,589 --> 01:39:57,491 THERE'S DIFFERENT OPPORTUNITIES 2571 01:39:57,558 --> 01:39:59,026 WHICH INVOLVE BIDIRECTIONAL 2572 01:39:59,093 --> 01:40:01,862 SHARING OF INFORMATION THROUGH 2573 01:40:01,929 --> 01:40:03,163 OUTRESEARCH CYCLE, CREATING 2574 01:40:03,230 --> 01:40:04,498 ON-RAMPS AND BRIDGES BETWEEN 2575 01:40:04,565 --> 01:40:07,201 WHAT WE DO AND NIH AND 2576 01:40:07,267 --> 01:40:08,302 COMMUNITIES WE'RE TRYING ON 2577 01:40:08,369 --> 01:40:08,569 RESEARCH. 2578 01:40:08,635 --> 01:40:10,070 OR TRYING TO REACH. 2579 01:40:10,137 --> 01:40:11,605 I THOUGHT THAT MADE A LOT OF 2580 01:40:11,672 --> 01:40:12,139 SENSE. 2581 01:40:12,206 --> 01:40:14,441 SOMEONE WHO HASN'T SEEN A LOT OF 2582 01:40:14,508 --> 01:40:15,642 THIS BEFORE. 2583 01:40:15,709 --> 01:40:18,045 AND HOW CAN NLM LEVERAGE ITS 2584 01:40:18,112 --> 01:40:20,447 POSITION TO SUSTAINABLY PROMOTE 2585 01:40:20,514 --> 01:40:23,751 EQUITABLE AND MEANINGFUL ACCESS 2586 01:40:23,817 --> 01:40:26,687 TO NIH-FUNDED RESEARCH FOR 2587 01:40:26,754 --> 01:40:29,223 COMMUNITIES OF END USERS WAS 2588 01:40:29,289 --> 01:40:29,490 DISCUSSED. 2589 01:40:29,556 --> 01:40:31,291 NLM UNIQUELY POSITIONED HERE TO 2590 01:40:31,358 --> 01:40:32,626 ADVANCE EQUITABLE OPEN SCIENCE, 2591 01:40:32,693 --> 01:40:34,161 GIVEN THE VARIOUS COMMUNITIES WE 2592 01:40:34,228 --> 01:40:35,462 ENGAGE WITH AND REACH, WHICH IS 2593 01:40:35,529 --> 01:40:35,929 GREAT. 2594 01:40:35,996 --> 01:40:38,098 YOU CAN THINK OF NLM AS A NODE 2595 01:40:38,165 --> 01:40:40,000 IN THE NETWORK, WE CAN ENVISION 2596 01:40:40,067 --> 01:40:42,336 NLM AT THE CENTER THEN WITH 2597 01:40:42,403 --> 01:40:44,872 INFORMATION FLOWING OUT FROM US 2598 01:40:44,938 --> 01:40:46,940 TO COMMUNITIES PERHAPS EVEN 2599 01:40:47,007 --> 01:40:48,742 VETERAN COMMUNITY AS AN EXAMPLE. 2600 01:40:48,809 --> 01:40:51,111 SO THAT WE'RE REALLY SHARING 2601 01:40:51,178 --> 01:40:56,583 WITH OTHERS AND ITERATING, IN MY 2602 01:40:56,650 --> 01:40:57,551 WORDS, WITH COMMUNITIES 2603 01:40:57,618 --> 01:40:58,986 BIDIRECTIONALLY, I THOUGHT IT 2604 01:40:59,052 --> 01:40:59,453 WAS INTERESTING. 2605 01:40:59,520 --> 01:41:01,488 SO NLM DOESN'T HAVE TO REACH 2606 01:41:01,555 --> 01:41:03,123 EVERY COMMUNITY, NLM HAS TO USE 2607 01:41:03,190 --> 01:41:05,325 A NETWORK WITH I THINK OF IT AS 2608 01:41:05,392 --> 01:41:06,860 HUBS AND SPOKES, WE'VE DONE THAT 2609 01:41:06,927 --> 01:41:09,163 IN THE V.A. A LOT SUCCESSFULLY. 2610 01:41:09,229 --> 01:41:12,032 SO, LAST PART, BEFORE THE 2611 01:41:12,099 --> 01:41:15,202 DISCUSSION, NLM IS DEVELOPING A 2612 01:41:15,269 --> 01:41:17,371 WORKSHOP, A NETWORK APPROACH TO 2613 01:41:17,438 --> 01:41:18,605 ADVANCING EQUITABLE OPEN 2614 01:41:18,672 --> 01:41:21,842 SCIENCE, AS I MENTIONED. 2615 01:41:21,909 --> 01:41:23,277 AND THE WORKSHOP I THINK WAS 2616 01:41:23,343 --> 01:41:24,912 ANNOUNCED TO BE TOWARD THE END 2617 01:41:24,978 --> 01:41:27,414 OF MAY OR EARLY JUNE, FINALIZING 2618 01:41:27,481 --> 01:41:29,316 SOME OF THAT. 2619 01:41:29,383 --> 01:41:32,586 AND UNDERSTANDING HOW NLM'S 2620 01:41:32,653 --> 01:41:35,456 RESOURCES ARE CURRENTLY ACCESSED 2621 01:41:35,522 --> 01:41:36,990 AND USED BY KNOWLEDGE 2622 01:41:37,057 --> 01:41:37,624 TRANSLATORS, IDENTIFYING 2623 01:41:37,691 --> 01:41:38,826 OPPORTUNITIES TO IMPROVE REACH 2624 01:41:38,892 --> 01:41:41,361 AND UTILITY OF NLM RESEARCH AND 2625 01:41:41,428 --> 01:41:42,663 TOOLS FOR KNOWLEDGE TRANSLATION, 2626 01:41:42,729 --> 01:41:45,833 THESE ARE THE AIMS OF THE 2627 01:41:45,899 --> 01:41:46,600 WORKSHOP, DEVELOP IDEAS AND 2628 01:41:46,667 --> 01:41:48,602 SUGGESTIONS FOR NLM TO BETTER 2629 01:41:48,669 --> 01:41:50,804 REACH AND ENGAGE KNOWLEDGE 2630 01:41:50,871 --> 01:41:52,306 TRANSLATORS, PROMOTING EQUITABLE 2631 01:41:52,372 --> 01:41:54,508 ACCESS TO HEALTH AND BIOMEDICAL 2632 01:41:54,575 --> 01:41:55,375 RESEARCH INFORMATION, HOPEFULLY 2633 01:41:55,442 --> 01:41:58,345 THIS WILL BE DONE BY CONVENING 2634 01:41:58,412 --> 01:42:00,214 20 TO 25 EXPERTS, KNOWLEDGE 2635 01:42:00,280 --> 01:42:02,783 TRANSLATORS, FOR A DAY AND A 2636 01:42:02,850 --> 01:42:06,119 HALF, THAT'S I THINK THE ASK. 2637 01:42:06,186 --> 01:42:08,555 AND REALLY LOOKING AT WHO IS THE 2638 01:42:08,622 --> 01:42:09,990 AUDIENCE, WHAT ARE ENGAGEMENT 2639 01:42:10,057 --> 01:42:12,860 GOALS, SO I THINK THERE ARE 2640 01:42:12,926 --> 01:42:14,561 ASPECTS THAT NEED TO BE FLESHED 2641 01:42:14,628 --> 01:42:14,895 OUT. 2642 01:42:14,962 --> 01:42:16,730 BUT THIS WAS THE DIRECTION, WHAT 2643 01:42:16,797 --> 01:42:18,632 CHALLENGES DO THEY HAVE, THESE 2644 01:42:18,699 --> 01:42:20,801 ARE FOR THE GOALS OF THE MEETING 2645 01:42:20,868 --> 01:42:24,404 AND WHAT WOULD WE ASK OF THE 2646 01:42:24,471 --> 01:42:24,872 PARTICIPANTS. 2647 01:42:24,938 --> 01:42:27,040 WHAT CAN NLM DO TO EASE THOSE 2648 01:42:27,107 --> 01:42:27,608 CHALLENGES? 2649 01:42:27,674 --> 01:42:29,476 HOW DO YOU ENGAGE WITH OTHER 2650 01:42:29,543 --> 01:42:30,010 KNOWLEDGE TRANSLATORS TO 2651 01:42:30,077 --> 01:42:32,212 INCREASE THE REACH AND IMPACT OF 2652 01:42:32,279 --> 01:42:33,847 YOUR EFFORTS, AND SO I THINK I 2653 01:42:33,914 --> 01:42:37,150 WILL TAKE A BREATH AND END THERE 2654 01:42:37,217 --> 01:42:38,785 AND HOPEFULLY MIRIAM AND OTHERS 2655 01:42:38,852 --> 01:42:43,724 THINK I'VE DONE JUSTICE TO THAT 2656 01:42:43,790 --> 01:42:44,791 SECTION AS WELL. 2657 01:42:44,858 --> 01:42:45,859 >> SOUNDS GREAT. 2658 01:42:45,926 --> 01:42:46,360 THANK YOU. 2659 01:42:46,426 --> 01:42:47,127 >> THANK YOU. 2660 01:42:47,194 --> 01:42:48,662 LIKE I SAID, I'VE LEARNED A LOT 2661 01:42:48,729 --> 01:42:55,569 BY LISTENING TO THESE TWO 2662 01:42:55,636 --> 01:42:56,136 PRESENTATIONS. 2663 01:42:56,203 --> 01:42:56,637 IT'S GREAT. 2664 01:42:56,703 --> 01:42:58,205 >> WONDERFUL. 2665 01:42:58,272 --> 01:43:01,008 IT'S AN EXCITING TIME IN THIS 2666 01:43:01,074 --> 01:43:02,042 SPACE, IT'S WONDERFUL TO SEE THE 2667 01:43:02,109 --> 01:43:04,311 GREAT WORK AT NLM. 2668 01:43:04,378 --> 01:43:13,186 ARE THERE QUESTIONS FROM THE 2669 01:43:13,253 --> 01:43:16,023 ATTENDEES FOR THIS WORKING 2670 01:43:16,089 --> 01:43:19,293 GROUP? 2671 01:43:19,359 --> 01:43:22,029 PHILIP, DO I SEE YOUR HAND GOING 2672 01:43:22,095 --> 01:43:22,796 UP? 2673 01:43:22,863 --> 01:43:23,063 >> YEAH. 2674 01:43:23,130 --> 01:43:23,430 >> REAL HAND 2675 01:43:23,497 --> 01:43:25,332 >> THE REAL HAND GOES UP FASTER 2676 01:43:25,399 --> 01:43:28,068 THAN THE OTHER HAND. 2677 01:43:28,135 --> 01:43:30,470 REGARDING THE OPEN SCIENCE AND 2678 01:43:30,537 --> 01:43:35,208 OPEN ACCESS TO MATERIALS, HOW 2679 01:43:35,275 --> 01:43:38,011 THAT'S PROLIFERATING, THESE 2680 01:43:38,078 --> 01:43:41,214 DAYS, IS THERE OPPORTUNITIES 2681 01:43:41,281 --> 01:43:46,453 FROM NLM OR EVEN SOME SORT OF 2682 01:43:46,520 --> 01:43:47,020 CROSS-POLLINATION AMONGST 2683 01:43:47,087 --> 01:43:48,522 FEDERAL AGENCIES TO BEGIN 2684 01:43:48,589 --> 01:43:54,995 WORKING ON TRANSLATION OF THAT, 2685 01:43:55,062 --> 01:43:56,830 SO RATHER THAN GOING WITH GOOGLE 2686 01:43:56,897 --> 01:43:58,699 TRANSLATOR OR SOMETHING LIKE 2687 01:43:58,765 --> 01:43:59,766 THAT, BUT ACTUALLY HAVING SOME 2688 01:43:59,833 --> 01:44:04,504 SORT OF MAYBE A MUCH MORE 2689 01:44:04,571 --> 01:44:05,739 IMPROVED SCIENTIFIC CONTEXTUAL 2690 01:44:05,806 --> 01:44:07,708 TRANSLATION THAT -- MAYBE THAT'S 2691 01:44:07,774 --> 01:44:09,776 A FUNDING PROPOSAL, JUST TO MAKE 2692 01:44:09,843 --> 01:44:13,747 SURE THAT ALL OF THE MILLIONS OF 2693 01:44:13,814 --> 01:44:14,815 ENGLISH -- SIMILAR TO MEDLINE 2694 01:44:14,881 --> 01:44:18,885 PLUS, WHERE THIS IS COMING FROM, 2695 01:44:18,952 --> 01:44:20,187 MEDLINE PLUS, SOME ENGLISH 2696 01:44:20,253 --> 01:44:24,558 RESEARCH CAN ALSO BE TRANSLATED 2697 01:44:24,625 --> 01:44:27,060 INTO SPANISH, PORTUGUESE, ET 2698 01:44:27,127 --> 01:44:28,595 CETERA, ET CETERA. 2699 01:44:28,662 --> 01:44:31,798 THAT'S PROBABLY A BROADER GROUP 2700 01:44:31,865 --> 01:44:32,532 QUESTION. 2701 01:44:32,599 --> 01:44:35,068 >> YES, SO WHAT I WAS SAYING 2702 01:44:35,135 --> 01:44:37,337 WE'VE BEEN LOOKING INTO 2703 01:44:37,404 --> 01:44:39,239 TRANSLATION IS COMPLICATED 2704 01:44:39,306 --> 01:44:40,240 BECAUSE THERE'S COPYRIGHT 2705 01:44:40,307 --> 01:44:41,408 ISSUES, YOU KNOW, RESOURCE 2706 01:44:41,475 --> 01:44:44,277 ISSUES, BUT ONE OF THE THINGS WE 2707 01:44:44,344 --> 01:44:50,851 HAVE BEEN DOING IS LOOKING AT 2708 01:44:50,917 --> 01:44:52,586 EXTENDING OUR JOURNAL REVIEW 2709 01:44:52,653 --> 01:44:57,357 PROCESSES TO BE MORE LANGUAGE 2710 01:44:57,424 --> 01:44:59,626 INCLUSIVE, HISTORICALLY PUBMED 2711 01:44:59,693 --> 01:45:02,462 CENTRAL WAS, YOU KNOW -- IT WAS 2712 01:45:02,529 --> 01:45:04,631 KIND OF AN ENGLISH-ONLY JOURNAL 2713 01:45:04,698 --> 01:45:04,898 ARCHIVE. 2714 01:45:04,965 --> 01:45:06,833 MEDLINE HAS ALWAYS BEEN MORE 2715 01:45:06,900 --> 01:45:08,335 INCLUSIVE OF LANGUAGES. 2716 01:45:08,402 --> 01:45:12,172 WE'VE BEEN TRYING TO DO OVER THE 2717 01:45:12,239 --> 01:45:14,041 LAST FEW YEARS IS, A, IDENTIFY 2718 01:45:14,107 --> 01:45:15,709 THOSE TITLES WITHIN MEDLINE THAT 2719 01:45:15,776 --> 01:45:18,011 WE CAN PROVIDE FULL TEXT TO IN 2720 01:45:18,078 --> 01:45:20,814 OTHER LANGUAGES, AND THEN WE'VE 2721 01:45:20,881 --> 01:45:24,117 ALSO BEEN LOOKING AT LEVERAGING 2722 01:45:24,184 --> 01:45:26,620 OUR JOURNAL REVIEW PROGRAM FOR 2723 01:45:26,687 --> 01:45:28,388 PMC TO INCLUDE SPANISH LANGUAGE 2724 01:45:28,455 --> 01:45:28,889 JOURNALS. 2725 01:45:28,955 --> 01:45:29,923 AND WE'VE BEEN DOING THAT FOR 2726 01:45:29,990 --> 01:45:31,224 ABOUT A YEAR NOW. 2727 01:45:31,291 --> 01:45:34,194 AND WE SEE IT AS A WAY, BOTH OF 2728 01:45:34,261 --> 01:45:35,595 REACHING MORE DIVERSE AUDIENCES, 2729 01:45:35,662 --> 01:45:39,533 BUT ENSURING OUR COLLECTION 2730 01:45:39,599 --> 01:45:41,835 REALLY DOES REFLECT THE GLOBAL 2731 01:45:41,902 --> 01:45:42,502 BIOMEDICAL LITERATURE, AND 2732 01:45:42,569 --> 01:45:45,672 THAT'S WHERE WE ARE ON THAT 2733 01:45:45,739 --> 01:45:45,906 LARGELY. 2734 01:45:45,972 --> 01:45:47,641 I THINK THERE ARE ADDITIONAL 2735 01:45:47,708 --> 01:45:49,943 LAYERS OF IT, EVEN WITHIN 2736 01:45:50,010 --> 01:45:52,546 ENGLISH, ABOUT THAT KIND OF 2737 01:45:52,612 --> 01:45:54,414 TRANSLATION OF THE RESEARCH TO 2738 01:45:54,481 --> 01:45:57,184 SOMETHING THAT HEALTH 2739 01:45:57,250 --> 01:45:59,553 PRACTITIONERS CAN USE, PATIENTS, 2740 01:45:59,619 --> 01:46:00,954 THE PUBLIC, THERE ARE LEVELS OF 2741 01:46:01,021 --> 01:46:04,157 THAT, I I THINK WHAT MIRIAM IS 2742 01:46:04,224 --> 01:46:05,859 WORKING ON WITH THE WORKSHOP 2743 01:46:05,926 --> 01:46:06,860 COULD START TO GET AT. 2744 01:46:06,927 --> 01:46:09,763 I'VE HEARD OF A NUMBER OF 2745 01:46:09,830 --> 01:46:11,598 EFFORTS, PLAIN LANGUAGE SUMMARY, 2746 01:46:11,665 --> 01:46:15,435 START HAVING A MOMENT AGAIN AND 2747 01:46:15,502 --> 01:46:17,437 I THINK IT'S AN INTERESTING AREA 2748 01:46:17,504 --> 01:46:22,142 THAT WILL CONTINUE TO EVOLVE. 2749 01:46:22,209 --> 01:46:23,276 SO, IT'S EXCITING. 2750 01:46:23,343 --> 01:46:24,544 >> I CAN IMAGINE THINGS EVEN IF 2751 01:46:24,611 --> 01:46:28,348 IT'S NOT THE FULL ARTICLE, 2752 01:46:28,415 --> 01:46:30,851 POSSIBLY THE CONCLUSION AS THE 2753 01:46:30,917 --> 01:46:31,952 POINT OF CARE RESOURCES LIKE TO 2754 01:46:32,018 --> 01:46:33,286 CALL IT THE CLINICAL PEARLS. 2755 01:46:33,353 --> 01:46:35,455 WHAT ARE THE MAIN FACTORS THAT 2756 01:46:35,522 --> 01:46:38,225 SOME CLINICIANS ABROAD CAN TAKE 2757 01:46:38,291 --> 01:46:39,826 FROM THIS, THINGS LIKE THAT. 2758 01:46:39,893 --> 01:46:40,727 >> YEAH, THAT'S A REALLY 2759 01:46:40,794 --> 01:46:41,461 INTERESTING THOUGHT. 2760 01:46:41,528 --> 01:46:43,130 I FEEL LIKE IF WE CAN GET 2761 01:46:43,196 --> 01:46:45,532 OURSELVES TO MORE OF THOSE PLAIN 2762 01:46:45,599 --> 01:46:46,666 LANGUAGE SUMMARIES THEY BECOME 2763 01:46:46,733 --> 01:46:47,834 MUCH MORE TRANSLATABLE. 2764 01:46:47,901 --> 01:46:52,005 SO IT MIGHT BE A MULTI-STEP 2765 01:46:52,072 --> 01:46:52,339 PROCESS. 2766 01:46:52,405 --> 01:46:53,740 STEVE POLITELY HAS HIS HAND UP 2767 01:46:53,807 --> 01:46:55,275 SO I'LL STOP. 2768 01:46:55,342 --> 01:46:57,344 >> ON THAT POINT, KATIE, THERE'S 2769 01:46:57,410 --> 01:46:59,646 GENERATIVE A.I. PROJECTS RIGHT 2770 01:46:59,713 --> 01:47:02,949 NOW ACROSS NIH WORKING ON PLAIN 2771 01:47:03,016 --> 01:47:04,684 LANGUAGE SUMMARIES AND GRADE 2772 01:47:04,751 --> 01:47:05,852 LEVEL TRANSLATIONS, WRITING IN 2773 01:47:05,919 --> 01:47:07,120 PLAIN LANGUAGE, AND I THINK THAT 2774 01:47:07,187 --> 01:47:09,089 WOULD BE THE INPUT YOU'RE 2775 01:47:09,156 --> 01:47:10,524 TALKING ABOUT. 2776 01:47:10,590 --> 01:47:14,361 AND SO WE MIGHT HAVE SOME 2777 01:47:14,427 --> 01:47:16,096 SCALABLE ALGORITHMIC APPROACHES 2778 01:47:16,163 --> 01:47:18,098 THAT DON'T REQUIRE EVEN EFFORTS 2779 01:47:18,165 --> 01:47:19,399 TO DO THE TRANSLATING. 2780 01:47:19,466 --> 01:47:29,342 THAT'S THE ART IN THIS. 2781 01:47:29,409 --> 01:47:30,343 GREAT QUESTION. 2782 01:47:30,410 --> 01:47:33,113 >> ALL RIGHT. 2783 01:47:33,180 --> 01:47:36,650 ANY OTHER QUESTIONS? 2784 01:47:36,716 --> 01:47:37,184 OKAY. 2785 01:47:37,250 --> 01:47:38,051 WONDERFUL. 2786 01:47:38,118 --> 01:47:40,453 WELL, WHAT WE'RE GOING TO DO, 2787 01:47:40,520 --> 01:47:41,988 WE'RE SLIGHTLY AHEAD OF 2788 01:47:42,055 --> 01:47:42,489 SCHEDULE. 2789 01:47:42,556 --> 01:47:46,459 SO I THINK WE'RE GOING TO MOVE 2790 01:47:46,526 --> 01:47:47,561 FORWARD WITH OUR NEXT 2791 01:47:47,627 --> 01:47:50,964 PRESENTATION, AND THEN HAVE A 2792 01:47:51,031 --> 01:47:53,166 BIT LONGER BREAK AFTERWARDS. 2793 01:47:53,233 --> 01:47:57,971 SO, WITH THAT, I WOULD LIKE TO 2794 01:47:58,038 --> 01:47:59,606 WELCOME DR. TERESA PRZYTYCKA, 2795 01:47:59,673 --> 01:48:02,676 WHO WILL BE PRESENTING ON 2796 01:48:02,742 --> 01:48:04,911 COMPUTATIONAL APPROACHES TO 2797 01:48:04,978 --> 01:48:07,881 STUDYING MUTATIONAL SIGNATURES. 2798 01:48:14,354 --> 01:48:24,931 >> I WILL SHARE MY SCREEN HERE. 2799 01:48:39,045 --> 01:48:41,214 LET ME CONFIRM THAT YOU CAN SEE 2800 01:48:41,281 --> 01:48:44,818 MY SLIDES OKAY. 2801 01:48:44,885 --> 01:48:45,085 >> YEP. 2802 01:48:45,151 --> 01:48:46,453 >> SO, GOOD AFTERNOON, 2803 01:48:46,519 --> 01:48:46,887 EVERYBODY. 2804 01:48:46,953 --> 01:48:50,056 MY NAME IS TERESA PRZYTYCKA. 2805 01:48:50,123 --> 01:48:53,026 AND I'M A SENIOR INVESTIGATOR IN 2806 01:48:53,093 --> 01:48:54,527 COMPUTATIONAL AND BIOLOGY BRANCH 2807 01:48:54,594 --> 01:49:02,002 OF NATIONAL LIBRARY OF MEDICINE. 2808 01:49:02,068 --> 01:49:04,404 LET ME START WITH AN 2809 01:49:04,471 --> 01:49:06,373 INTRODUCTION TO MY GROUP. 2810 01:49:06,439 --> 01:49:12,512 THIS IS A RATHER DIVERSE GROUP 2811 01:49:12,579 --> 01:49:13,813 OF RESEARCHERS, MOSTLY COMPUTER 2812 01:49:13,880 --> 01:49:19,486 SCIENTISTS, SO PEOPLE TRAINED IN 2813 01:49:19,552 --> 01:49:22,122 COMPUTER SCIENCE. 2814 01:49:22,188 --> 01:49:23,556 THE DEVELOPMENT OF COMPUTATIONAL 2815 01:49:23,623 --> 01:49:27,294 METHODS THAT ARE ADVANCING 2816 01:49:27,360 --> 01:49:28,461 UNDERSTANDING OF BIOMOLECULAR 2817 01:49:28,528 --> 01:49:29,229 SYSTEMS. 2818 01:49:29,296 --> 01:49:31,531 TO BE MORE SPECIFIC, WE'RE 2819 01:49:31,598 --> 01:49:37,904 WORKING WITH TOPICS LIKE 2820 01:49:37,971 --> 01:49:39,539 UNDERSTANDING DEREGULATION, 2821 01:49:39,606 --> 01:49:43,710 STARTING NETWORK BIOLOGY, HOW 2822 01:49:43,777 --> 01:49:46,079 BIOLOGIC ENTITIES CONNECT, TUMOR 2823 01:49:46,146 --> 01:49:47,847 EVOLUTION, AND ALSO AS NEEDED WE 2824 01:49:47,914 --> 01:49:58,425 DEVELOP ALGORITHMS FOR THE NEW 2825 01:50:02,996 --> 01:50:04,364 TECHNOLOGIES, A DIVERSE SET OF 2826 01:50:04,431 --> 01:50:04,764 INTEREST. 2827 01:50:04,831 --> 01:50:06,466 AT A GIVEN TIME WE FOCUS ON 2828 01:50:06,533 --> 01:50:08,635 SEVERAL OF THOSE TOPICS. 2829 01:50:08,702 --> 01:50:13,239 AND TODAY WHAT I SELECTED FOR 2830 01:50:13,306 --> 01:50:15,742 THE PRESENTATION AS RELATED TO 2831 01:50:15,809 --> 01:50:18,278 NEWLY EMERGING CONCEPT IN CANCER 2832 01:50:18,345 --> 01:50:20,447 BIOLOGY KNOWN AS MUTATION 2833 01:50:20,513 --> 01:50:20,880 SIGNATURES. 2834 01:50:20,947 --> 01:50:25,251 WHEN I SELECTED THIS TOPIC FOR 2835 01:50:25,318 --> 01:50:27,020 SEVERAL REASONS. 2836 01:50:27,087 --> 01:50:28,788 FIRSTLY, NEW AND EMERGING, 2837 01:50:28,855 --> 01:50:30,657 INTERESTING TO SEE HOW IT 2838 01:50:30,724 --> 01:50:35,462 PROVIDES NEW INSIGHT TO CANCER. 2839 01:50:35,528 --> 01:50:37,998 NEXT, WE'VE BEEN WORKING FOR A 2840 01:50:38,064 --> 01:50:40,700 COUPLE YEARS ALREADY. 2841 01:50:40,767 --> 01:50:46,406 NEXT, IT HELPS ME TO EXEMPLIFY 2842 01:50:46,473 --> 01:50:52,879 HOW VARIOUS TYPE OF DATA CAN BE 2843 01:50:52,946 --> 01:50:53,747 COMBINED INDIVIDUAL DATASETS 2844 01:50:53,813 --> 01:50:56,149 WOULD NOT BE ABLE TO PROVIDE. 2845 01:50:56,216 --> 01:50:58,051 FINALLY VERY INTERESTED IN 2846 01:50:58,118 --> 01:51:01,888 DEVELOPING AND APPLYING OUR 2847 01:51:01,955 --> 01:51:02,956 ALGORITHMIC KNOWLEDGE TO ANALYZE 2848 01:51:03,023 --> 01:51:03,757 THIS DATA. 2849 01:51:03,823 --> 01:51:08,028 SO YOU CAN ALSO SEE HOW NOT ONLY 2850 01:51:08,094 --> 01:51:14,234 DATA BUT DEVELOP NEW METHODS, 2851 01:51:14,300 --> 01:51:17,771 NEW APPROACHES, AND PROVIDE 2852 01:51:17,837 --> 01:51:20,807 VARIOUS INSIGHTS. 2853 01:51:20,874 --> 01:51:26,413 SO, I'LL START MY PRESENTATION 2854 01:51:26,479 --> 01:51:27,213 WITH INTRODUCTIONS. 2855 01:51:27,280 --> 01:51:31,084 I'LL SAY A FEW MORE WORDS WHY 2856 01:51:31,151 --> 01:51:34,721 STUDIES ARE INTERESTED, WHY THIS 2857 01:51:34,788 --> 01:51:38,024 TOPIC IN THE CANCER BIOLOGIST, 2858 01:51:38,091 --> 01:51:39,192 THEN I WILL PRESENT SOME OF 2859 01:51:39,259 --> 01:51:44,030 METHODS WE DEVELOP, NOT GOING TO 2860 01:51:44,097 --> 01:51:45,532 GO INTO TECHNICAL METHODS, JUST 2861 01:51:45,598 --> 01:51:48,501 TRY TO PROVIDE SOME GENERAL 2862 01:51:48,568 --> 01:51:51,271 OVERVIEW, I WILL SAY SOME VISION 2863 01:51:51,337 --> 01:51:57,377 FOR OUR STATUS IN THIS AREA. 2864 01:51:57,444 --> 01:51:57,811 OKAY. 2865 01:51:57,877 --> 01:52:03,149 SO, LET ME STOP MY POINTER HERE. 2866 01:52:04,117 --> 01:52:04,250 OKAY. 2867 01:52:04,317 --> 01:52:08,555 SO, AS YOU I'M SURE ARE AWARE 2868 01:52:08,621 --> 01:52:10,824 OF, THE DNA MOLECULE IN EVERY 2869 01:52:10,890 --> 01:52:14,427 SINGLE CELL OF OUR ORGANISM IS 2870 01:52:14,494 --> 01:52:17,163 EXPOSED TO VARIOUS TYPE OF 2871 01:52:17,230 --> 01:52:17,630 DAMAGE. 2872 01:52:17,697 --> 01:52:20,433 THOSE MAY BE DAMAGE THAT RELATES 2873 01:52:20,500 --> 01:52:21,901 TO EXTERNAL FACTORS LIKE UV 2874 01:52:21,968 --> 01:52:27,440 LIGHT OR, SAY, SMOKING OR SOME 2875 01:52:27,507 --> 01:52:27,774 DRUGS. 2876 01:52:27,841 --> 01:52:31,277 BUT ALSO NORMAL CELL FUNCTIONS 2877 01:52:31,344 --> 01:52:33,913 ARE NOT PERFECT. 2878 01:52:33,980 --> 01:52:37,417 SO THEY DEMONSTRATE JUST APPEARS 2879 01:52:37,484 --> 01:52:40,253 RANDOMLY THROUGH THE NATURAL 2880 01:52:40,320 --> 01:52:40,553 CELL CYCLE. 2881 01:52:40,620 --> 01:52:42,989 PERHAPS NOT SO WELL APPRECIATED 2882 01:52:43,056 --> 01:52:45,291 IS HOW MUCH DAMAGE THERE IS. 2883 01:52:45,358 --> 01:52:47,827 IT'S BEEN ESTIMATED THAT ON 2884 01:52:47,894 --> 01:52:51,431 AVERAGE, THAT CELL CAN ACQUIRE 2885 01:52:51,498 --> 01:52:55,301 AS MANY AS 10 TO THE 5th 2886 01:52:55,368 --> 01:52:56,136 LESION PER DAY. 2887 01:52:56,202 --> 01:53:01,274 THIS IS A NORMAL AMOUNT OF 2888 01:53:01,341 --> 01:53:01,941 DAMAGE. 2889 01:53:02,008 --> 01:53:05,445 HOWEVER REPAIR MECHANISM WILL 2890 01:53:05,512 --> 01:53:11,117 REPAIR THOSE DAMAGE. 2891 01:53:11,184 --> 01:53:16,156 REPAIRED, A SMALL AMOUNT OF THIS 2892 01:53:16,222 --> 01:53:19,325 UNREPAIRED LESIONS BECAME 2893 01:53:19,392 --> 01:53:22,162 MUTATIONS AND THEY 2894 01:53:22,228 --> 01:53:22,529 (INDISCERNIBLE). 2895 01:53:22,595 --> 01:53:24,364 ALSO THOSE MUTATIONS ARE 2896 01:53:24,430 --> 01:53:25,331 HARMLESS IN PATIENTS, DO NOT 2897 01:53:25,398 --> 01:53:29,502 HAVE IMPACT ON CELL FUNCTION. 2898 01:53:29,569 --> 01:53:32,105 WE REFER TO THEM AS 2899 01:53:32,172 --> 01:53:32,539 (INDISCERNIBLE). 2900 01:53:32,605 --> 01:53:34,174 OCCASIONALLY A MUTATION MAY 2901 01:53:34,240 --> 01:53:35,942 PROVIDE ADVANTAGE TO CANCER GROW 2902 01:53:36,009 --> 01:53:40,313 OR JUST CELL GROW, AND BE 2903 01:53:40,380 --> 01:53:44,017 MUTATION THAT DERIVE CANCER 2904 01:53:44,083 --> 01:53:44,384 (INDISCERNIBLE). 2905 01:53:44,450 --> 01:53:48,321 MOST OF THE STUDY WAS IN CANCER, 2906 01:53:48,388 --> 01:53:52,192 AND IN OTHER DISEASES, WAS TO 2907 01:53:52,258 --> 01:53:57,197 LOOK AT WHAT DRIVES THE DISEASE. 2908 01:53:57,263 --> 01:54:01,401 HOWEVER, NOW THOSE MUTATIONS 2909 01:54:01,467 --> 01:54:05,638 THAT WE PREVIOUSLY NEGLECTED MAY 2910 01:54:05,705 --> 01:54:07,140 BE INTERESTING TO STUDY AND LOOK 2911 01:54:07,207 --> 01:54:07,507 AT. 2912 01:54:07,574 --> 01:54:10,877 IT'S BEEN APPRECIATED FOR SOME 2913 01:54:10,944 --> 01:54:13,846 TIME ALREADY THAT VARIOUS 2914 01:54:13,913 --> 01:54:14,681 MUTAGENIC PROCESSES LEAVE 2915 01:54:14,747 --> 01:54:17,116 IMPRINTS ON THE HUMAN GENOME. 2916 01:54:17,183 --> 01:54:20,520 FOR EXAMPLE, UV LIGHT IS KNOWN 2917 01:54:20,587 --> 01:54:21,988 TO MUTATE, TO PROVIDE MUTATION, 2918 01:54:22,055 --> 01:54:25,925 SO IF THIS HERE IS REFERENCE 2919 01:54:25,992 --> 01:54:36,469 GENOME, AND LEE -- BELOW IS 2920 01:54:38,171 --> 01:54:45,678 MUTATED, C TO T, AND ACTUALLY 2921 01:54:45,745 --> 01:54:46,379 PARTICULARLY (INDISCERNIBLE) TO 2922 01:54:46,446 --> 01:54:47,880 THE MUTATIONS. 2923 01:54:47,947 --> 01:54:50,583 WE HAVE OTHER MUTAGENIC 2924 01:54:50,650 --> 01:54:51,117 PROCESSES. 2925 01:54:51,184 --> 01:54:55,421 HERE IS AN ENZYME OUR BODY 2926 01:54:55,488 --> 01:54:57,156 PRODUCES, CAN BE MUTAGENIC, AND 2927 01:54:57,223 --> 01:55:00,660 THIS ALSO CAN MUTATE C TO T, BUT 2928 01:55:00,727 --> 01:55:02,629 MUTATIONS ARE VERY LIKELY, OR 2929 01:55:02,695 --> 01:55:08,001 MORE LIKELY, I SHOULD SAY, WHERE 2930 01:55:08,067 --> 01:55:10,937 THE C FROM NUCLEOTIDE, FOLLOWING 2931 01:55:11,004 --> 01:55:11,938 THIS WAY. 2932 01:55:12,005 --> 01:55:16,609 SO WE APPEAR TO HAVE THOSE 2933 01:55:16,676 --> 01:55:19,012 CHARACTERISTICS MUTATIONS THAT 2934 01:55:19,078 --> 01:55:21,014 CAN BE LINKED BACK TO PROCESSES 2935 01:55:21,080 --> 01:55:22,882 THAT GENERATE THEM. 2936 01:55:22,949 --> 01:55:24,851 AND THIS HAVING ENOUGH DATA 2937 01:55:24,917 --> 01:55:26,719 PROVIDES INTERESTING APPROACH 2938 01:55:26,786 --> 01:55:29,922 THAT WE CAN START MUTAGENIC 2939 01:55:29,989 --> 01:55:35,795 PROCESS THAT WE OBSERVE IN HUMAN 2940 01:55:35,862 --> 01:55:36,229 GENOME. 2941 01:55:36,296 --> 01:55:38,631 I'M IN ORDER TO DISCUSS THOSE 2942 01:55:38,698 --> 01:55:41,701 PATHWAYS WE HAVE TO DEFINE MORE 2943 01:55:41,768 --> 01:55:44,637 FORMALLY WHAT MUTATION 2944 01:55:44,704 --> 01:55:45,738 SIGNATURES ARE. 2945 01:55:45,805 --> 01:55:47,273 I WILL INTRODUCE THE CONCEPT AND 2946 01:55:47,340 --> 01:55:49,876 YOU CAN -- YOU WILL SEE THERE 2947 01:55:49,942 --> 01:55:52,312 MAY BE OTHER WAYS OF FINDING 2948 01:55:52,378 --> 01:55:54,247 FORMALIZING THIS IDEA. 2949 01:55:54,314 --> 01:55:56,349 HERE WE FORMALIZE AS FOLLOWS. 2950 01:55:56,416 --> 01:55:59,085 WE DIVIDE ALL THE MUTATIONS INTO 2951 01:55:59,152 --> 01:56:01,387 SO-CALLED MUTATIONAL CATEGORIES. 2952 01:56:01,454 --> 01:56:03,256 MUTATIONAL CATEGORIES WILL BE 2953 01:56:03,323 --> 01:56:08,361 DEFINED HERE IS A MUTATION, WE 2954 01:56:08,428 --> 01:56:13,099 LOOK AT NUCLEOTIDE, CENTRAL ONE 2955 01:56:13,166 --> 01:56:16,269 IS MUTATED, AND THE FLANKING ONE 2956 01:56:16,336 --> 01:56:18,004 PROVIDES (INDISCERNIBLE). 2957 01:56:18,071 --> 01:56:20,440 WE CAN HAVE 96 MUTATIONAL 2958 01:56:20,506 --> 01:56:24,711 CATEGORIES, SO MANY COMBINATION 2959 01:56:24,777 --> 01:56:29,849 OF THIS, OF THIS CONFIGURATION. 2960 01:56:29,916 --> 01:56:32,585 AND DEFINE MUTATION NOW 2961 01:56:32,652 --> 01:56:34,020 SIGNATURE AS DISTRIBUTION OF 2962 01:56:34,087 --> 01:56:35,321 CATEGORIES. 2963 01:56:35,388 --> 01:56:36,522 WE LIST THE CATEGORIES HERE IN 2964 01:56:36,589 --> 01:56:37,824 SOME ORDER. 2965 01:56:37,890 --> 01:56:40,793 AND THEN FOR EVERY CATEGORY WE 2966 01:56:40,860 --> 01:56:43,963 SEE WHAT IS THE PROBABILITY 2967 01:56:44,030 --> 01:56:46,065 GIVEN MUTAGENIC PROCESS GENERATE 2968 01:56:46,132 --> 01:56:49,869 MUTATION OF THIS CATEGORY. 2969 01:56:49,936 --> 01:56:51,304 SO, WE HAVE MUTATION SIGNATURES, 2970 01:56:51,371 --> 01:56:53,573 NOW OF COURSE WE EVEN DON'T KNOW 2971 01:56:53,639 --> 01:56:55,541 ALL THE MUTATION PROCESSES THAT 2972 01:56:55,608 --> 01:56:57,410 THEY MAY BE AROUND, AND EVEN 2973 01:56:57,477 --> 01:56:59,145 LAST WE REALLY DON'T KNOW IN 2974 01:56:59,212 --> 01:57:03,349 ADVANCE WHAT SIGNATURE MIGHT BE. 2975 01:57:03,416 --> 01:57:04,550 SO HERE COMPUTATIONAL APPROACH, 2976 01:57:04,617 --> 01:57:08,154 I HAVE HERE SOME, YOU KNOW, 2977 01:57:08,221 --> 01:57:12,392 OTHER MORE EXAMPLE, THAT VARIOUS 2978 01:57:12,458 --> 01:57:13,159 THOSE PROCESS REALLY MUTAGENIC 2979 01:57:13,226 --> 01:57:17,563 SIGNATURE AS YOU CAN APPRECIATE 2980 01:57:17,630 --> 01:57:18,898 FROM THIS GRAPHIC REPRESENTATION 2981 01:57:18,965 --> 01:57:20,867 ARE IN THE DIFFERENT BUT THE 2982 01:57:20,933 --> 01:57:24,036 NEXT QUESTION IS HOW WE CAN FIND 2983 01:57:24,103 --> 01:57:26,439 MUTATION SIGNATURE, HOW WE CAN 2984 01:57:26,506 --> 01:57:27,640 IN OUR -- IDENTIFY DIFFERENT 2985 01:57:27,707 --> 01:57:29,609 PATTERNS THAT ARE PRESENT IN THE 2986 01:57:29,675 --> 01:57:29,942 GENOME. 2987 01:57:30,009 --> 01:57:33,212 SO THIS INTERESTINGLY IS DONE, 2988 01:57:33,279 --> 01:57:34,380 COULD BE DONE EXPERIMENTALLY BUT 2989 01:57:34,447 --> 01:57:35,314 REALLY DON'T KNOW WHICH 2990 01:57:35,381 --> 01:57:37,049 EXPERIMENT TO DO. 2991 01:57:37,116 --> 01:57:41,854 THIS IS COMPUTATIONALLY DONE BY 2992 01:57:41,921 --> 01:57:45,258 TRYING TO IDENTIFY THE OPTIMAL 2993 01:57:45,324 --> 01:57:48,795 NUMBER OF THOSE SIGNATURES THAT 2994 01:57:48,861 --> 01:57:50,730 EXPLAIN ALL THE DATA THAT ARE 2995 01:57:50,797 --> 01:57:53,699 AVAILABLE TO US. 2996 01:57:53,766 --> 01:57:55,435 THE TECHNICAL METHOD BEING USED 2997 01:57:55,501 --> 01:58:00,907 AT THIS WAS BEING USED FOR THIS 2998 01:58:00,973 --> 01:58:04,110 WAS -- IS CALLED NON-NEGATIVE 2999 01:58:04,177 --> 01:58:06,379 MATRIX FACTORIZATION, OTHERS 3000 01:58:06,446 --> 01:58:09,115 HAVE BEEN PROPOSED SO WE HAVE 3001 01:58:09,182 --> 01:58:10,416 HAVE MUTATION OF SIGNATURES. 3002 01:58:10,483 --> 01:58:14,954 THERE'S A WHOLE DATABASE OF 3003 01:58:15,021 --> 01:58:17,457 MUTATION OF SIGNATURES, IN OUR 3004 01:58:17,523 --> 01:58:19,358 -- AND FOR MANY MUTATION 3005 01:58:19,425 --> 01:58:20,726 SIGNATURES WE HAVE SOME GOOD 3006 01:58:20,793 --> 01:58:23,930 UNDERSTANDING WHAT THEY MIGHT BE 3007 01:58:23,996 --> 01:58:24,297 DOING. 3008 01:58:24,363 --> 01:58:27,433 SOME OF THEM WE JUST HAVE WHAT 3009 01:58:27,500 --> 01:58:29,502 SORT OF PROCESSES THEY MIGHT BE 3010 01:58:29,569 --> 01:58:33,773 ASSOCIATED WITH BUT FOR SOME WE 3011 01:58:33,840 --> 01:58:35,508 HAVE NEW CLUE. 3012 01:58:35,575 --> 01:58:38,544 WE KNOW THERE ARE PROCESS, HOW 3013 01:58:38,611 --> 01:58:40,980 WE'RE GOING TO GO BACK AND 3014 01:58:41,047 --> 01:58:42,515 UNDERSTAND MUTATIONAL PROCESSES, 3015 01:58:42,582 --> 01:58:47,086 AND HOW WE CAN INFER THE ROLE IN 3016 01:58:47,153 --> 01:58:48,855 CANCER DEVELOPMENT. 3017 01:58:48,921 --> 01:58:51,591 IN ADDITION TO -- ONCE WE DEFINE 3018 01:58:51,657 --> 01:58:53,426 THIS MUTATIONAL SIGNATURE, IF WE 3019 01:58:53,493 --> 01:58:56,596 HAVE NEW CANCER GENOME WE CAN 3020 01:58:56,662 --> 01:58:57,597 ASK THE QUESTION, WHICH 3021 01:58:57,663 --> 01:58:59,665 SIGNATURES ARE PRESENT AND HOW 3022 01:58:59,732 --> 01:59:01,534 MANY MUTATIONS CAN BE ATTRIBUTED 3023 01:59:01,601 --> 01:59:03,736 TO EACH OF THOSE PROCESSES. 3024 01:59:03,803 --> 01:59:06,239 AGAIN, THERE'S A NUMBER OF 3025 01:59:06,305 --> 01:59:07,874 METHODS THAT DEVELOP, OTHER 3026 01:59:07,940 --> 01:59:14,580 CONTRIBUTED ONE OF THOSE 3027 01:59:14,647 --> 01:59:16,782 METHODS, FIRST GROUP ADDRESS 3028 01:59:16,849 --> 01:59:20,152 STATISTICAL ISSUE OF INFERRING 3029 01:59:20,219 --> 01:59:22,555 THIS APPROACH, THIS SIGNATURE, 3030 01:59:22,622 --> 01:59:25,191 SOME APPROACHES BEING BY OTHER 3031 01:59:25,258 --> 01:59:25,925 METHODS TOO. 3032 01:59:25,992 --> 01:59:29,795 SO WHY WE WOULD LIKE TO STUDY 3033 01:59:29,862 --> 01:59:30,897 THE SIGNATURE, GOOD CANCER 3034 01:59:30,963 --> 01:59:32,532 (INDISCERNIBLE) FROM IT. 3035 01:59:32,598 --> 01:59:34,500 AS SCIENTISTS WE'RE INTERESTED 3036 01:59:34,567 --> 01:59:36,903 TO UNDERSTAND CANCER BETTER SO 3037 01:59:36,969 --> 01:59:47,613 SCIENTIFIC INQUIRY IS IMPORTANT 3038 01:59:47,680 --> 01:59:48,414 HERE. 3039 01:59:48,481 --> 01:59:50,816 UNDERSTANDINGMUTATION SIGNATURE 3040 01:59:50,883 --> 01:59:54,987 HELPS, PREVENTION AS WELL AS 3041 01:59:55,054 --> 01:59:55,221 THERAPY. 3042 01:59:55,288 --> 01:59:56,389 DIAGNOSTICS, YOU HAVE SOME 3043 01:59:56,455 --> 01:59:57,723 NUMBER OF CANCER PATIENT 3044 01:59:57,790 --> 01:59:59,926 EMERGING IN SOME AREA. 3045 01:59:59,992 --> 02:00:02,962 THEN WE CAN IDENTIFY WHAT IS THE 3046 02:00:03,029 --> 02:00:03,863 NEW MUTATIONAL SIGNATURE 3047 02:00:03,930 --> 02:00:08,000 PATIENTS CAN SHARE AND TRY TO 3048 02:00:08,067 --> 02:00:12,038 UNDERSTAND WHETHER THERE'S SOME 3049 02:00:12,104 --> 02:00:13,706 BEHAVIOR OF SOME MAYBE EXPOSURE 3050 02:00:13,773 --> 02:00:16,208 OF MAYBE COMMON TO THOSE 3051 02:00:16,275 --> 02:00:21,147 PATIENTS, AND IN THIS WAY HOW TO 3052 02:00:21,213 --> 02:00:26,385 OBSERVE THE POTENTIAL NEW 3053 02:00:26,452 --> 02:00:27,987 (INDISCERNIBLE) AND PREVENT FROM 3054 02:00:28,054 --> 02:00:29,522 ELIMINATED ENVIRONMENT. 3055 02:00:29,589 --> 02:00:30,823 INTERESTINGLY THAT ALSO HAS 3056 02:00:30,890 --> 02:00:32,258 IMPORTANCE OF THERAPY, SOME 3057 02:00:32,325 --> 02:00:38,164 SIGNATURES THAT WE OBSERVE ARE 3058 02:00:38,230 --> 02:00:41,667 RELATED TO DNA TO IMPERFECTION 3059 02:00:41,734 --> 02:00:43,202 IN DNA REPAIR MECHANISM. 3060 02:00:43,269 --> 02:00:45,071 ONE FAMOUS EXAMPLE WHERE ONE OF 3061 02:00:45,137 --> 02:00:47,173 THE SIGNATURES HAS BEEN 3062 02:00:47,239 --> 02:00:49,141 ASSOCIATED WITH PARTICULAR DNA 3063 02:00:49,208 --> 02:00:53,980 DAMAGE, ONCE WE UNDERSTAND THAT 3064 02:00:54,046 --> 02:00:55,514 THE SIGNATURE IS (INDISCERNIBLE) 3065 02:00:55,581 --> 02:00:57,783 DNA DAMAGE, YET CELL SURVIVE, 3066 02:00:57,850 --> 02:01:00,086 SOME WAY THE CELL BYPASSES THIS 3067 02:01:00,152 --> 02:01:02,488 DAMAGE USING A DIFFERENT REPAIR 3068 02:01:02,555 --> 02:01:05,424 MECHANISM, WE UNDERSTAND ENOUGH 3069 02:01:05,491 --> 02:01:07,293 OF BIOLOGY TO SAY, OKAY, WE'LL 3070 02:01:07,360 --> 02:01:10,429 TARGET BY DIRECT THIS WAY OF BY 3071 02:01:10,496 --> 02:01:13,099 HASSING THE DAMAGE IN THE CELL 3072 02:01:13,165 --> 02:01:18,004 AND KILL THE CELL. 3073 02:01:18,070 --> 02:01:22,642 THIS IS FOR BREAST CANCER, WHERE 3074 02:01:22,708 --> 02:01:27,747 THE PATIENTS HAVE THE -- WHEN WE 3075 02:01:27,813 --> 02:01:29,882 OBSERVE MUTATIONAL SIGNATURE, 3076 02:01:29,949 --> 02:01:33,986 WHATEVER RESPONSE TO INHIBITOR, 3077 02:01:34,053 --> 02:01:37,423 SIMILARLY WE SEE THIS SIGNATURE 3078 02:01:37,490 --> 02:01:43,229 IN THOSE PATIENTS RESPONSE TO 3079 02:01:43,295 --> 02:01:43,963 PARP INHIBITOR. 3080 02:01:44,030 --> 02:01:46,265 FOR UNDERSTANDING THEY MAY HAVE 3081 02:01:46,332 --> 02:01:50,870 ALSO TO PREDICT RESPONSE FOR 3082 02:01:50,936 --> 02:01:52,171 IMMUNOTHERAPY. 3083 02:01:52,238 --> 02:01:53,806 OKAY. 3084 02:01:53,873 --> 02:01:56,876 SO WITH THAT, YOU KNOW, AS I 3085 02:01:56,942 --> 02:01:58,444 SHOW YOU THE MUTATION, 3086 02:01:58,511 --> 02:02:00,846 PROBABILITY DISTRIBUTION, ALL BY 3087 02:02:00,913 --> 02:02:03,015 THEMSELVES ARE VERY KNOWN 3088 02:02:03,082 --> 02:02:04,884 INFORMATIVE, SO HOW WE CAN 3089 02:02:04,950 --> 02:02:07,420 CONNECT MUTATION SIGNATURE TO 3090 02:02:07,486 --> 02:02:10,589 MOLECULAR PROCESS TO UNDERSTAND 3091 02:02:10,656 --> 02:02:11,657 BETTER WHAT THEY REPRESENT IN 3092 02:02:11,724 --> 02:02:15,728 TERMS OF CANCER DEVELOPMENT. 3093 02:02:15,795 --> 02:02:18,798 THE WAY WE APPROACH THIS 3094 02:02:18,864 --> 02:02:19,799 QUESTION, BY DATA INTEGRATION, 3095 02:02:19,865 --> 02:02:21,767 TRY TO UNDERSTAND HOW THIS 3096 02:02:21,834 --> 02:02:23,302 MUTATION OF SIGNATURE ARE 3097 02:02:23,369 --> 02:02:25,404 RELATED TO GENE EXPRESSIONS IN 3098 02:02:25,471 --> 02:02:28,240 THE SAME PATIENTS, HOW THEY ARE 3099 02:02:28,307 --> 02:02:31,410 RELATED TO ENVIRONMENT, HOW THEY 3100 02:02:31,477 --> 02:02:34,346 MAY BE RELATED TO THOSE DRIVER 3101 02:02:34,413 --> 02:02:36,015 MUTATIONS I MENTIONED, KNOWN TO 3102 02:02:36,082 --> 02:02:37,116 DRIVE CANCER. 3103 02:02:37,183 --> 02:02:38,851 ALSO WHAT THE INTERACTION IS 3104 02:02:38,918 --> 02:02:41,787 BETWEEN DNA AND DAMAGE AND 3105 02:02:41,854 --> 02:02:42,655 REPAIR. 3106 02:02:42,722 --> 02:02:45,424 I'M NOT GOING TO -- WE HAVE FOUR 3107 02:02:45,491 --> 02:02:50,429 LINES OF THE STUDY, I'M GOING TO 3108 02:02:50,496 --> 02:02:55,367 SAY, YOU KNOW, BRIEFLY DISCUSS 3109 02:02:55,434 --> 02:02:58,671 ON THE FIRST THREE. 3110 02:02:58,738 --> 02:03:00,973 SO, WHY DO WE EXPECT THAT THERE 3111 02:03:01,040 --> 02:03:03,275 WILL BE SOME INTERACTION BETWEEN 3112 02:03:03,342 --> 02:03:05,344 THOSE MUTATIONAL SIGNATURES AND 3113 02:03:05,411 --> 02:03:08,514 GENE EXPRESSION? 3114 02:03:08,581 --> 02:03:09,281 SO GENE EXPRESSION FOR -- I 3115 02:03:09,348 --> 02:03:11,784 DON'T KNOW IF YOU HEARD OR NOT, 3116 02:03:11,851 --> 02:03:13,753 FOCUSED ON MOLECULAR BIOLOGY, IS 3117 02:03:13,819 --> 02:03:16,822 A WAY OF MEASURING THE ACTIVITY 3118 02:03:16,889 --> 02:03:22,595 OF GENES IN THE GIVEN CELL. 3119 02:03:22,661 --> 02:03:29,735 SO, IF WE -- WHEN WE COLLECT 3120 02:03:29,802 --> 02:03:30,836 INFORMATION ABOUT CANCER 3121 02:03:30,903 --> 02:03:31,837 SAMPLES, WE DO COLLECT 3122 02:03:31,904 --> 02:03:34,774 INFORMATION NOT ONLY ABOUT THE 3123 02:03:34,840 --> 02:03:36,509 MUTATION BUT ALSO ABOUT GENE 3124 02:03:36,575 --> 02:03:37,510 EXPRESSION, AND OFTEN FOR THE 3125 02:03:37,576 --> 02:03:38,511 SAME PATIENTS. 3126 02:03:38,577 --> 02:03:40,112 QUITE OFTEN WE HAVE THE TWO 3127 02:03:40,179 --> 02:03:42,848 DATASETS, ON ONE SIDE WE HAVE 3128 02:03:42,915 --> 02:03:45,484 THIS MUTATIONAL DATA FROM WHICH 3129 02:03:45,551 --> 02:03:47,686 WE CAN INFORM DECISION SIGNATURE 3130 02:03:47,753 --> 02:03:50,289 SO FOR EVERY PATIENT WE CAN SEE 3131 02:03:50,356 --> 02:03:51,090 WHICH SIGNATURES ARE PRESENT IN 3132 02:03:51,157 --> 02:03:52,391 THE PATIENT AND WHAT THE 3133 02:03:52,458 --> 02:03:55,327 STRENGTH OF THE SIGNATURE IS. 3134 02:03:55,394 --> 02:03:57,496 AT THE SAME TIME FOR THE SAME 3135 02:03:57,563 --> 02:03:58,964 PATIENTS WE KNOW GENE EXPRESSION 3136 02:03:59,031 --> 02:04:01,267 THAT MEANS FOR EVERY SINGLE 3137 02:04:01,333 --> 02:04:03,669 GENES WE KNOW WHAT IS THE, YOU 3138 02:04:03,736 --> 02:04:06,172 KNOW, WHAT IS THE EXPRESSION OF 3139 02:04:06,238 --> 02:04:09,909 THIS GENE ON A GIVEN PATIENT. 3140 02:04:09,975 --> 02:04:14,079 NOW WE CAN CONSIDER IF THERE'S A 3141 02:04:14,146 --> 02:04:16,148 CORRELATION WITHIN GENE 3142 02:04:16,215 --> 02:04:16,549 EXPRESSION. 3143 02:04:16,615 --> 02:04:18,217 AND THE STRENGTH OF SIGNATURE. 3144 02:04:18,284 --> 02:04:19,652 SO FOR EVERY PAIR GENE AND 3145 02:04:19,718 --> 02:04:21,921 SIGNATURE WE CAN LOOK AT ALL OUR 3146 02:04:21,987 --> 02:04:24,023 SET OF PATIENTS THAT ARE 3147 02:04:24,089 --> 02:04:26,559 AVAILABLE HERE AND SEE IS THERE 3148 02:04:26,625 --> 02:04:27,793 A CORRELATION BETWEEN STRENGTH 3149 02:04:27,860 --> 02:04:32,131 OF SIGNATURE AND GENE 3150 02:04:32,198 --> 02:04:32,531 EXPRESSION. 3151 02:04:32,598 --> 02:04:34,400 TO UNDERSTAND THIS TYPE OF 3152 02:04:34,466 --> 02:04:36,936 ANALYSIS, TO BE NOISY, IN 3153 02:04:37,002 --> 02:04:39,138 SYSTEMS BIOLOGY WE TYPICALLY TRY 3154 02:04:39,205 --> 02:04:40,673 TO PULL TOGETHER THINGS THAT 3155 02:04:40,739 --> 02:04:42,408 CONNECT SIGNAL FOR THAT 3156 02:04:42,474 --> 02:04:45,578 CONNECTED GENE SO THAT WE CAN 3157 02:04:45,644 --> 02:04:47,413 STRENGTH OF THE SIGNALS. 3158 02:04:47,479 --> 02:04:49,281 FOR EVERY GENE SO FAR WE CAN SEE 3159 02:04:49,348 --> 02:04:54,086 WHETHER OR NOT THE GENE IS 3160 02:04:54,153 --> 02:04:54,887 CORRELATED WITH GIVEN SIGNATURE, 3161 02:04:54,954 --> 02:04:56,722 NOW WE HAVE TO PULL SOME SIGNAL 3162 02:04:56,789 --> 02:04:58,257 OUT OF IT. 3163 02:04:58,324 --> 02:05:02,394 SO WHAT YOU DO, WE IDENTIFY 3164 02:05:02,461 --> 02:05:04,697 GROUP OF GENES THAT HAVE SAME 3165 02:05:04,763 --> 02:05:06,031 RELATION WITH SIGNATURE, SO 3166 02:05:06,098 --> 02:05:08,667 GENES IN GROUP C THEY ARE ALL 3167 02:05:08,734 --> 02:05:11,103 HIGHLY EXPRESSED IN THOSE FIRST 3168 02:05:11,170 --> 02:05:11,971 THREE SIGNATURES. 3169 02:05:12,037 --> 02:05:13,906 SO ONCE WE HAVE THIS CLUSTERING, 3170 02:05:13,973 --> 02:05:15,541 WE CAN LOOK AT EACH OF THESE 3171 02:05:15,608 --> 02:05:17,676 GROUP AND SAY WHAT ARE THE GENES 3172 02:05:17,743 --> 02:05:19,812 THAT ARE PRESENT THERE, WHAT ARE 3173 02:05:19,879 --> 02:05:21,914 THE PATHWAYS THAT ARE RELATED, 3174 02:05:21,981 --> 02:05:27,486 WHAT ARE THE PATHWAYS DEPRESSED? 3175 02:05:27,553 --> 02:05:29,855 AS AN EXAMPLE OF THIS TYPE OF 3176 02:05:29,922 --> 02:05:33,826 ANALYSIS WE LOOK AT THE BREAST 3177 02:05:33,893 --> 02:05:36,462 CANCER, AND WE WERE -- SO HERE 3178 02:05:36,528 --> 02:05:39,632 AGAIN YOU'LL HAVE THE -- THE 3179 02:05:39,698 --> 02:05:40,499 RESPONSE MUTATION SIGNATURE, 3180 02:05:40,566 --> 02:05:43,702 OVER HERE I PUT WHAT WE KNOW 3181 02:05:43,769 --> 02:05:44,703 ABOUT THE SIGNATURE. 3182 02:05:44,770 --> 02:05:47,172 AND THE GROUP OF GENES 3183 02:05:47,239 --> 02:05:49,275 CORRELATED WITH THE CORRELATION 3184 02:05:49,341 --> 02:05:50,809 WITH THE SIGNATURE SHOWN. 3185 02:05:50,876 --> 02:05:52,778 SO ONE INTERESTING OBSERVATION 3186 02:05:52,845 --> 02:05:55,180 THAT WAS DONE QUITE EARLY IN THE 3187 02:05:55,247 --> 02:06:01,320 ANALYSIS OF THE SIGNATURES IS 3188 02:06:01,387 --> 02:06:04,156 TWO SIGNATURES HERE, THEY 3189 02:06:04,223 --> 02:06:06,125 ACCUMULATE WITH AGE BUT DO NOT 3190 02:06:06,191 --> 02:06:10,095 CORRELATE WITH EACHER. 3191 02:06:10,162 --> 02:06:13,599 THAT CLOCK, TWO DIFFERENT CLOCKS 3192 02:06:13,666 --> 02:06:14,900 THAT ARE ASSOCIATED WITH EACH OF 3193 02:06:14,967 --> 02:06:16,235 THE SIGNATURES. 3194 02:06:16,302 --> 02:06:19,071 WE'D LIKE TO UNDERSTAND THE 3195 02:06:19,138 --> 02:06:26,412 DIFFERENCE, WHY DOES THIS 3196 02:06:26,478 --> 02:06:27,780 SIGNATURE, THESE TWO ACCUMULATE. 3197 02:06:27,846 --> 02:06:30,983 THIS HELP US TO SEE THAT, 3198 02:06:31,050 --> 02:06:33,185 EVERYTHING IS DIFFERENT, 3199 02:06:33,252 --> 02:06:34,920 DIFFERENT CORRELATION WITH FIRST 3200 02:06:34,987 --> 02:06:36,121 SIGNATURE AND DIFFERENT GENES 3201 02:06:36,188 --> 02:06:38,524 WITH EXPRESSION CORRELATE WITH 3202 02:06:38,590 --> 02:06:39,625 OTHER CLOCK-LIKE SIGNATURE. 3203 02:06:39,692 --> 02:06:41,694 WE DIVE INTO THE TOOLS THAT 3204 02:06:41,760 --> 02:06:43,562 ALLOW US TO SEE WHAT IS THE 3205 02:06:43,629 --> 02:06:45,731 FUNCTION OF THOSE GENES, AND WE 3206 02:06:45,798 --> 02:06:47,766 SEE THE SECOND SIGNATURE HERE 3207 02:06:47,833 --> 02:06:52,104 CORRELATE WITH CELL CYCLE. 3208 02:06:52,171 --> 02:06:55,808 WHILE THE FIRST ONE CORRELATE 3209 02:06:55,874 --> 02:06:57,476 WITH PARTICULAR ACTIVITY OF 3210 02:06:57,543 --> 02:06:58,544 PARTICULAR DNA REPAIR PATHWAY 3211 02:06:58,610 --> 02:07:00,746 KNOWN TO BE ACTIVATED IN 3212 02:07:00,813 --> 02:07:03,349 RESPONSE TO MANY ENVIRONMENT UP 3213 02:07:03,415 --> 02:07:06,752 CLOSE. 3214 02:07:06,819 --> 02:07:09,254 NOW WE UNDERSTAND THAT THE FIRST 3215 02:07:09,321 --> 02:07:11,457 CLOCK IS CELL CYCLE CLOCK, THE 3216 02:07:11,523 --> 02:07:13,092 SECOND CLOCK IS MORE LIKE WALL 3217 02:07:13,158 --> 02:07:16,362 CLOCK, A TIME CLOCK. 3218 02:07:16,428 --> 02:07:19,431 AND BOTH CLOCKS ACTUALLY ARE 3219 02:07:19,498 --> 02:07:21,066 DYSREGULATED BECAUSE IF CANCER 3220 02:07:21,133 --> 02:07:22,401 GOES QUICKLY WE HAVE 3221 02:07:22,468 --> 02:07:24,503 ACCUMULATION OF THE MUTATION DUE 3222 02:07:24,570 --> 02:07:25,804 TO CELL CYCLE. 3223 02:07:25,871 --> 02:07:28,407 IF AN INDIVIDUAL IS EXPOSED TO 3224 02:07:28,474 --> 02:07:33,679 REALLY A VERY HIGH AMOUNT OF 3225 02:07:33,746 --> 02:07:34,646 SOME ENVIRONMENTAL FACTOR WE 3226 02:07:34,713 --> 02:07:36,281 LOSE CORRELATION WITH TIME BUT 3227 02:07:36,348 --> 02:07:38,050 HAVE CORRELATION WITH THIS 3228 02:07:38,117 --> 02:07:38,450 EXPOSURE. 3229 02:07:38,517 --> 02:07:42,988 SO, THIS IS ONE WAY WE CAN LINK 3230 02:07:43,055 --> 02:07:45,958 THE -- WE CAN LEARN FROM -- BY 3231 02:07:46,025 --> 02:07:47,893 DOING JOINT ANALYSIS OF 3232 02:07:47,960 --> 02:07:50,796 MUTATIONAL SIGNATURE AND GENE 3233 02:07:50,863 --> 02:07:52,431 EXPRESSION, SOME INFORMATION 3234 02:07:52,498 --> 02:07:54,400 ABOUT THE SIGNATURES. 3235 02:07:54,466 --> 02:08:00,072 WE CAN ALSO -- HOWEVER THIS BLOT 3236 02:08:00,139 --> 02:08:02,274 HERE, OUR ANALYSIS CANNOT REALLY 3237 02:08:02,341 --> 02:08:02,608 DIFFERENTIATE. 3238 02:08:02,674 --> 02:08:06,745 THERE SEEMS TO BE OTHER 3239 02:08:06,812 --> 02:08:07,746 SIGNATURES SITTING HERE, SEEMS 3240 02:08:07,813 --> 02:08:10,349 TO BE CORRELATED WITH THE SAME 3241 02:08:10,416 --> 02:08:11,884 GENE EXPRESSION PREFERENCE. 3242 02:08:11,950 --> 02:08:13,519 WE CANNOT JUST LEARN SOMETHING 3243 02:08:13,585 --> 02:08:14,186 MORE SPECIFIC ABOUT THEM. 3244 02:08:14,253 --> 02:08:16,922 SO WE HAVE TO DEVELOP A NEW 3245 02:08:16,989 --> 02:08:17,256 METHOD. 3246 02:08:17,322 --> 02:08:21,860 HERE A MEMBER OF MY GROUP CAME 3247 02:08:21,927 --> 02:08:28,300 UP WITH AN IDEA WE'RE GOING TO 3248 02:08:28,367 --> 02:08:30,803 USE (INDISCERNIBLE) AND USE A 3249 02:08:30,869 --> 02:08:34,440 NETWORK THAT A NETWORK WILL 3250 02:08:34,506 --> 02:08:36,408 CONTAIN BOTH SIGNATURES HERE 3251 02:08:36,475 --> 02:08:40,779 SHOWN IN BROWN, AND GREEN, IN 3252 02:08:40,846 --> 02:08:46,385 GREEN, AND WE ARE BASED ON THE 3253 02:08:46,452 --> 02:08:48,787 GENE EXPRESSION FOR GENES AND 3254 02:08:48,854 --> 02:08:51,723 SIGNATURE, SO SIGNATURES, WE'RE 3255 02:08:51,790 --> 02:08:53,725 GOING TO BUILD RELATIONSHIP 3256 02:08:53,792 --> 02:08:55,894 BETWEEN THEM TO SEE WHAT 3257 02:08:55,961 --> 02:08:56,662 INFLUENCE WHAT. 3258 02:08:56,728 --> 02:09:00,165 HE BUILT THIS INFLUENCE GRAPH. 3259 02:09:00,232 --> 02:09:04,436 WITHOUT GOING TOO DEEPLY INTO 3260 02:09:04,503 --> 02:09:07,072 TECHNICAL ASPECT OF THIS 3261 02:09:07,139 --> 02:09:08,474 TRANSFECTION WE'RE ABLE TO DIVE 3262 02:09:08,540 --> 02:09:09,241 AND UNDERSTAND THINGS WE 3263 02:09:09,308 --> 02:09:10,375 COULDN'T SEE BEFORE. 3264 02:09:10,442 --> 02:09:16,248 WE CAN SEE, FOR EXAMPLE, THAT 3265 02:09:16,315 --> 02:09:18,450 THERE'S RELATION BETWEEN APOBEC 3266 02:09:18,517 --> 02:09:22,054 SIGNATURE, THAT FIRST ONE THE 3267 02:09:22,121 --> 02:09:22,788 DOUBLE-STRANDED BREAKS CAUSES 3268 02:09:22,855 --> 02:09:24,356 APPEARANCE OF THE OTHER. 3269 02:09:24,423 --> 02:09:27,092 WE CAN ALSO FIND OUT THAT 3270 02:09:27,159 --> 02:09:28,293 THERE'S A SIGNATURE NUMBER 8 3271 02:09:28,360 --> 02:09:30,362 WHICH WAS NOT UNDERSTOOD BEFORE, 3272 02:09:30,429 --> 02:09:34,533 NOW WE CAN SEE THIS LINKED TO 3273 02:09:34,600 --> 02:09:38,904 DAMAGE IN THE -- OR ACTIVITY OF 3274 02:09:38,971 --> 02:09:42,741 PARTICULAR DNA REPAIR PATHWAY, 3275 02:09:42,808 --> 02:09:44,343 KNOWN AS NERVE PATHWAYS. 3276 02:09:44,409 --> 02:09:45,911 WE HAVE DIFFERENT WAYS, 3277 02:09:45,978 --> 02:09:47,012 DIFFERENT METHODS, TO INFER 3278 02:09:47,079 --> 02:09:51,183 DIFFERENT PROPERTIES OF THE DATA 3279 02:09:51,250 --> 02:09:53,218 AND LEARN NEW ASPECT. 3280 02:09:53,285 --> 02:09:57,422 I WOULD LIKE TO TELL YOU ABOUT 3281 02:09:57,489 --> 02:10:00,425 HOW WE CAN USE THIS MUTATIONAL 3282 02:10:00,492 --> 02:10:02,327 SIGNATURE TO TELL SOMETHING 3283 02:10:02,394 --> 02:10:04,530 ABOUT THE RESPONSE TO 3284 02:10:04,596 --> 02:10:04,963 ENVIRONMENT. 3285 02:10:05,030 --> 02:10:07,699 AND JUST TO SAY A PROJECT THAT 3286 02:10:07,766 --> 02:10:13,505 WE STARTED TO UNDERTAKE AT THE 3287 02:10:13,572 --> 02:10:17,342 BEGINNING OF THE COVID EPIDEMIC 3288 02:10:17,409 --> 02:10:20,312 WERE -- THERE WAS A NUMBER OF 3289 02:10:20,379 --> 02:10:25,250 PAPERS THAT WERE TRYING TO 3290 02:10:25,317 --> 02:10:27,085 SUGGEST WHAT SMOKING DOES TO 3291 02:10:27,152 --> 02:10:27,653 COVID. 3292 02:10:27,719 --> 02:10:31,590 THAT SOME OF THEM SUGGESTED 3293 02:10:31,657 --> 02:10:33,659 SMOKING HAS PREDICTIVE EFFECT, 3294 02:10:33,725 --> 02:10:36,428 SOME SAID THAT JUST THE 3295 02:10:36,495 --> 02:10:42,768 OPPOSITE, THAT SMOKING, YOU 3296 02:10:42,834 --> 02:10:45,204 KNOW, MAKES IT WORSE, AND DOES 3297 02:10:45,270 --> 02:10:46,738 THIS INFERENCE APPEAR TO BE FOR 3298 02:10:46,805 --> 02:10:50,342 US AT LEAST VERY KIND OF 3299 02:10:50,409 --> 02:10:53,979 ASSOCIATED BASE AND MAYBE 3300 02:10:54,046 --> 02:10:56,715 STATISTICALLY NOT JUSTIFIED. 3301 02:10:56,782 --> 02:10:59,218 SO, WE GENERALIZE WE USE 3302 02:10:59,284 --> 02:11:02,054 MUTATION SIGNATURE AND DATA TO 3303 02:11:02,120 --> 02:11:03,689 HELP US UNDERSTAND WHAT SMOKING 3304 02:11:03,755 --> 02:11:08,060 DOES TO CANCER, TO LUNGS, WHAT 3305 02:11:08,126 --> 02:11:09,294 SMOKING DOES TO LUNG. 3306 02:11:09,361 --> 02:11:11,029 AND WHY? 3307 02:11:11,096 --> 02:11:14,633 WELL, BECAUSE THE PARTICULAR 3308 02:11:14,700 --> 02:11:16,535 LUNG CANCER, AT LEAST CARCINOMA 3309 02:11:16,602 --> 02:11:25,711 WE HAVE IN THE DATABASES COLLECT 3310 02:11:25,777 --> 02:11:29,881 BY TGA, MOST GET CANCER DUE TO 3311 02:11:29,948 --> 02:11:31,516 SMOKING. 3312 02:11:31,583 --> 02:11:33,885 NOW, THE DATA COLLECTED FOR 3313 02:11:33,952 --> 02:11:38,123 CANCER STUDY OFTEN CONTAINS NOT 3314 02:11:38,190 --> 02:11:40,259 ONLY THE TUMOR GENE EXPRESSION 3315 02:11:40,325 --> 02:11:42,027 BUT FOR THE KNOWN MUTATION, SO 3316 02:11:42,094 --> 02:11:43,562 WHAT IS DIFFERENT YOU HAVE A 3317 02:11:43,629 --> 02:11:47,699 COHORT OF PEOPLE WHO HAVE BEEN 3318 02:11:47,766 --> 02:11:49,134 EXPOSED TO SMOKING, AND WE HAVE 3319 02:11:49,201 --> 02:11:50,335 AN EXPRESSION FOR THOSE 3320 02:11:50,402 --> 02:11:51,670 INDIVIDUALS IN THE NORMAL 3321 02:11:51,737 --> 02:11:53,272 TISSUE, AT LEAST CONTROL TISSUE, 3322 02:11:53,338 --> 02:11:56,775 AND WE CAN PERHAPS UNDERSTAND 3323 02:11:56,842 --> 02:11:58,410 HOW THE CHANGES IN NORMAL TISSUE 3324 02:11:58,477 --> 02:12:02,481 DEPENDS ON THE AMOUNT OF 3325 02:12:02,547 --> 02:12:02,814 SMOKING. 3326 02:12:02,881 --> 02:12:04,383 USUALLY PEOPLE SAY THIS IS A 3327 02:12:04,449 --> 02:12:07,052 PACK CIGARETTES, OTHER TYPE OF 3328 02:12:07,119 --> 02:12:08,954 CIGARETTES, MOST PEOPLE DO NOT, 3329 02:12:09,021 --> 02:12:11,590 SO WHAT WE HERE CAN DO IS 3330 02:12:11,657 --> 02:12:13,225 LEVERAGE MUTATION SIGNATURE TO 3331 02:12:13,292 --> 02:12:16,428 KNOW HOW MUCH AN INDIVIDUAL HAS 3332 02:12:16,495 --> 02:12:17,829 SMOKING, THIS MUTATIONAL 3333 02:12:17,896 --> 02:12:19,031 SIGNATURE SMOKING SIGNATURE 3334 02:12:19,097 --> 02:12:21,433 CORRELATES QUITE WELL WITH 3335 02:12:21,500 --> 02:12:22,301 EXPOSURE TO SMOKING. 3336 02:12:22,367 --> 02:12:26,038 NOW WE HAVE A SET OF PATIENTS, 3337 02:12:26,104 --> 02:12:27,673 WE LOOK AT THEIR NORMAL SHOW FOR 3338 02:12:27,739 --> 02:12:31,376 EACH OF THOSE PATIENTS, WE 3339 02:12:31,443 --> 02:12:33,145 KNOW -- WE ESTIMATE EXPOSURE TO 3340 02:12:33,211 --> 02:12:33,478 SMOKING. 3341 02:12:33,545 --> 02:12:35,213 SO THOSE PATIENTS WE ALSO KNOW 3342 02:12:35,280 --> 02:12:37,316 BECAUSE THE DATA HAVE BEEN 3343 02:12:37,382 --> 02:12:38,950 ALREADY COLLECTED FOR THE 3344 02:12:39,017 --> 02:12:40,786 PROPOSED CANCER STUDY, WE LOOK 3345 02:12:40,852 --> 02:12:42,321 AT CONTROL TISSUE, WE KNOW GENE 3346 02:12:42,387 --> 02:12:45,824 EXPRESSION FOR EACH OF THE 3347 02:12:45,891 --> 02:12:46,825 PATIENTS, SO METHODS I JUST 3348 02:12:46,892 --> 02:12:51,096 DESCRIBED TO SEE HOW THE GENE 3349 02:12:51,163 --> 02:12:52,731 EXPRESSION IS CHANGING BUT WE 3350 02:12:52,798 --> 02:12:56,535 NEEDED TO TAKE IT ONE STEP 3351 02:12:56,601 --> 02:12:57,336 FURTHER. 3352 02:12:57,402 --> 02:12:58,537 LUNG IS COMPLICATED TISSUE, 3353 02:12:58,603 --> 02:13:01,907 CONTAINS DIFFERENT CELL TYPES. 3354 02:13:01,973 --> 02:13:04,643 AND RECENT ADVANCE OF SINGLE 3355 02:13:04,710 --> 02:13:06,178 CELL TECHNOLOGY ALLOWS US TO 3356 02:13:06,244 --> 02:13:07,713 TAKE THIS GENE EXPRESSION ON THE 3357 02:13:07,779 --> 02:13:11,116 LUNG AND USE THIS IN EXPRESSION 3358 02:13:11,183 --> 02:13:13,085 TO IDENTIFY THE PROPORTION OF 3359 02:13:13,151 --> 02:13:15,854 DIFFERENT TYPE OF CELL IN LUNGS. 3360 02:13:15,921 --> 02:13:20,759 SO, WE ASK THE QUESTION, USING 3361 02:13:20,826 --> 02:13:25,130 THIS -- IN THIS SIS CIBERSORT, 3362 02:13:25,197 --> 02:13:29,735 THAT CAN GIVE GENE EXPRESSION 3363 02:13:29,801 --> 02:13:34,206 DIFFERENT TISSUE TYPES, HOW 3364 02:13:34,272 --> 02:13:38,577 SMOKING MAY CHANGE OR UPSET THIS 3365 02:13:38,643 --> 02:13:40,545 BALANCE, REPROGRAMMING OF LUNG 3366 02:13:40,612 --> 02:13:41,012 TISSUE. 3367 02:13:41,079 --> 02:13:43,215 AND AS WE EXPECTED WE COULD 3368 02:13:43,281 --> 02:13:44,516 REALLY IDENTIFY USING THIS 3369 02:13:44,583 --> 02:13:48,019 APPROACH, WE COULD REALLY SEE 3370 02:13:48,086 --> 02:13:50,989 HOW SMOKING INFLUENCES CELL TYPE 3371 02:13:51,056 --> 02:13:53,892 COMPOSITION, JUST CELLS, MAIN 3372 02:13:53,959 --> 02:13:57,896 CELL TYPES THAT ARE PRESENT IN 3373 02:13:57,963 --> 02:13:59,965 LUNG AND HOW CAN BE TRANSFERRED 3374 02:14:00,031 --> 02:14:04,569 TO EACH OTHER. 3375 02:14:04,636 --> 02:14:08,407 HERE IS JUST OUR, YOU KNOW, 3376 02:14:08,473 --> 02:14:10,041 RELATIONSHIP BETWEEN AMOUNT OF 3377 02:14:10,108 --> 02:14:13,211 SMOKE AND CHANGES IN CELL TYPE 3378 02:14:13,278 --> 02:14:15,614 PROPORTION, WHAT WE SEE STRONGLY 3379 02:14:15,680 --> 02:14:17,149 SMOKING INCREASE PROPORTION OF 3380 02:14:17,215 --> 02:14:20,519 GOBLET CELLS, THOSE ARE CELLS 3381 02:14:20,585 --> 02:14:24,790 THAT PRODUCE MUCUS, THEY SAME 3382 02:14:24,856 --> 02:14:28,193 TIME DECREASED PROPORTION OF 3383 02:14:28,260 --> 02:14:33,865 TYPE 1 CELLS THAT MAKE THE 3384 02:14:33,932 --> 02:14:35,233 RESPONSIBLE GAS EXCHANGE. 3385 02:14:35,300 --> 02:14:37,169 SO YOU HAVE MORE MUCUS, LESS 3386 02:14:37,235 --> 02:14:40,005 ABILITY TO GAS EXCHANGE, THE 3387 02:14:40,071 --> 02:14:41,106 VERY IMPORTANT BALANCE BETWEEN 3388 02:14:41,173 --> 02:14:44,176 THE DIFFERENT CELL TYPES IN 3389 02:14:44,242 --> 02:14:53,251 LUNGS IS ALTERED BY SMOKING. 3390 02:14:53,318 --> 02:14:53,585 OKAY. 3391 02:14:53,652 --> 02:14:55,987 SO, ANOTHER EXAMPLE THAT AGAIN 3392 02:14:56,054 --> 02:15:02,160 HOW WE CAN DIVE INTO AN EXISTING 3393 02:15:02,227 --> 02:15:05,163 DATA AND UNDERSTAND NEW 3394 02:15:05,230 --> 02:15:06,598 BIOLOGICS, THIS RELATIONSHIP IS 3395 02:15:06,665 --> 02:15:09,868 IN MUTATIONAL SIGNATURE. 3396 02:15:09,935 --> 02:15:11,736 REMEMBER MUTATIONAL SIGNATURE TO 3397 02:15:11,803 --> 02:15:14,473 IDENTIFY MUTATIONAL SIGNATURE WE 3398 02:15:14,539 --> 02:15:17,209 USE THOSE PASSENGER MUTATIONS, 3399 02:15:17,275 --> 02:15:21,246 MUTATIONS NOT NECESSARILY 3400 02:15:21,313 --> 02:15:22,781 INFLUENCE CANCER, THE DIFFERENCE 3401 02:15:22,848 --> 02:15:27,619 BETWEEN SIGNALS AND CANCER 3402 02:15:27,686 --> 02:15:30,455 DRIVERS. 3403 02:15:30,522 --> 02:15:31,756 AGAIN, TWO WAYS. 3404 02:15:31,823 --> 02:15:36,361 WE CAN HAVE THAT MUTATIONAL 3405 02:15:36,428 --> 02:15:39,064 PROCESSES, CAN ACTUALLY CAUSE 3406 02:15:39,130 --> 02:15:39,865 SPECIFIC CANCER-DRIVING 3407 02:15:39,931 --> 02:15:41,166 MUTATIONS, THERE'S SOME EXAMPLES 3408 02:15:41,233 --> 02:15:43,802 KNOWN TO BE -- THIS TO BE 3409 02:15:43,869 --> 02:15:44,870 HAPPEN. 3410 02:15:44,936 --> 02:15:48,106 SINCE OTHER POSSIBILITY AS WELL, 3411 02:15:48,173 --> 02:15:52,477 THAT CANCER-DRIVING MUTATIONS, 3412 02:15:52,544 --> 02:15:55,547 MUTATION IN CANCER PATIENTS, MAY 3413 02:15:55,614 --> 02:15:57,616 ACTIVATE SOME MUTATION. 3414 02:15:57,682 --> 02:16:00,352 SO, OUR STUDY FOCUS ON THIS 3415 02:16:00,418 --> 02:16:01,019 SECOND ONE. 3416 02:16:01,086 --> 02:16:04,623 AND AM GOING TO BRIEFLY TELL YOU 3417 02:16:04,689 --> 02:16:09,427 A FEW WORDS ABOUT IT. 3418 02:16:09,494 --> 02:16:12,063 SO, WE -- THE APPROACH HERE THAT 3419 02:16:12,130 --> 02:16:15,567 WE USED IS BASED ON OUR 3420 02:16:15,634 --> 02:16:18,637 EXPERTISE IN SO-CALLED NETWORK 3421 02:16:18,703 --> 02:16:19,170 BIOLOGY. 3422 02:16:19,237 --> 02:16:21,673 SO WHAT IT DOES, THERE'S AN 3423 02:16:21,740 --> 02:16:24,075 EFFORT TO UNDERSTAND HOW VARIOUS 3424 02:16:24,142 --> 02:16:27,178 GENES ARE RELATED TO EACH OTHER. 3425 02:16:27,245 --> 02:16:30,582 USING DIVERSE SET OF DATA, YOU 3426 02:16:30,649 --> 02:16:34,753 KNOW, PEOPLE INFER THOSE WHAT WE 3427 02:16:34,819 --> 02:16:37,822 CALL INTRODUCTION NETWORKS WHICH 3428 02:16:37,889 --> 02:16:39,024 SUMMARIZE BASED HOW VARIOUS 3429 02:16:39,090 --> 02:16:41,426 GENES INTERACT WITH EACH OTHER. 3430 02:16:41,493 --> 02:16:45,697 AND WHY IT'S RELEVANT IS THAT IF 3431 02:16:45,764 --> 02:16:49,901 WE SHOW MUTATION IN THIS GENE 3432 02:16:49,968 --> 02:16:51,369 KRAS ACTIVATES CERTAIN 3433 02:16:51,436 --> 02:16:53,104 SIGNATURES, IF THOSE GENES ARE 3434 02:16:53,171 --> 02:16:56,608 CLOSELY INTERACTING WITH EACH 3435 02:16:56,675 --> 02:16:58,376 OTHER, MUTATION IN BRAF, 3436 02:16:58,443 --> 02:16:59,477 ACTIVATE SAME SIGNATURES. 3437 02:16:59,544 --> 02:17:02,881 SO THIS IS IDEA OF NETWORK 3438 02:17:02,948 --> 02:17:05,483 BIOLOGY, IS TO NOT LOOK AT GENES 3439 02:17:05,550 --> 02:17:08,219 IN ISOLATION BUT LOOK AT THEM AS 3440 02:17:08,286 --> 02:17:13,792 A GROUP OF CONNECTED GENES 3441 02:17:13,858 --> 02:17:14,459 ASSUMING IF PERTURBANCE, 3442 02:17:14,526 --> 02:17:16,094 MUTATION, WAS SEEN IN THIS 3443 02:17:16,161 --> 02:17:21,566 PATHWAY IT'S GOING TO HAVE 3444 02:17:21,633 --> 02:17:22,901 RELATED EFFECTS. 3445 02:17:22,968 --> 02:17:25,837 USING THIS, WE CAN NOW SAY, 3446 02:17:25,904 --> 02:17:28,607 OKAY, WE CAN CONSIDER OTHER 3447 02:17:28,673 --> 02:17:31,776 PATIENTS, SIGNATURE OF INTEREST, 3448 02:17:31,843 --> 02:17:35,146 AND THEN, YOU KNOW, FOLLOW THE 3449 02:17:35,213 --> 02:17:36,214 PATIENT FROM -- ACCORDING TO 3450 02:17:36,281 --> 02:17:39,951 RESPONSE OF THE SIGNATURE OF 3451 02:17:40,018 --> 02:17:40,318 INTEREST. 3452 02:17:40,385 --> 02:17:42,687 WE ALSO KNOW THE DRIVER 3453 02:17:42,754 --> 02:17:45,323 MUTATIONS IN EACH PATIENT AND WE 3454 02:17:45,390 --> 02:17:50,462 ALSO HAVE THIS EXTERNAL 3455 02:17:50,528 --> 02:17:51,296 INFORMATION ABOUT THE 3456 02:17:51,363 --> 02:17:51,796 INTERACTION NETWORK. 3457 02:17:51,863 --> 02:17:56,601 AND NOW WE ASK THE QUESTION, 3458 02:17:56,668 --> 02:17:57,702 WERE MUTATIONS IN SUBNETWORKS, 3459 02:17:57,769 --> 02:18:02,741 WHETHER THEY ARE PARTICULARLY 3460 02:18:02,807 --> 02:18:04,709 LIKELY TO CAUSE THE MUTATION 3461 02:18:04,776 --> 02:18:05,143 SIGNATURE. 3462 02:18:05,210 --> 02:18:09,381 HERE WHAT WE USE ANOTHER 3463 02:18:09,447 --> 02:18:11,349 TECHNIQUE, PREVIOUSLY I 3464 02:18:11,416 --> 02:18:15,086 MENTIONED CIRCULATION, HERE IS 3465 02:18:15,153 --> 02:18:16,621 ANOTHER TECHNIQUE, INTERLINEAR 3466 02:18:16,688 --> 02:18:19,224 PROGRAMMING, WE UTILIZE TO 3467 02:18:19,290 --> 02:18:22,427 IDENTIFY THIS NETWORK. 3468 02:18:22,494 --> 02:18:24,829 WE CALL IT REALLY FOR CASES 3469 02:18:24,896 --> 02:18:28,433 WHERE WE KNOW THAT'S MUTATION OF 3470 02:18:28,500 --> 02:18:30,502 SIGNATURES IS CAUSED BY 3471 02:18:30,568 --> 02:18:31,736 PARTICULAR DRIVER MUTATION LIKE 3472 02:18:31,803 --> 02:18:33,238 THE SAME SIGNATURE THAT I 3473 02:18:33,304 --> 02:18:38,076 MENTIONED AT THE VERY BEGINNING, 3474 02:18:38,143 --> 02:18:38,843 COMBINATION, MUTATION IN BREAST 3475 02:18:38,910 --> 02:18:41,479 CANCER KNOWN TO BE CAUSED BY 3476 02:18:41,546 --> 02:18:43,248 BRCA1, BRCA2, SO WE CORRECTLY 3477 02:18:43,314 --> 02:18:46,718 INFERRED THAT BUT ALSO INFERRED 3478 02:18:46,785 --> 02:18:49,254 POTENTIAL CAUSAL MUTATION FOR 3479 02:18:49,320 --> 02:18:51,322 OTHER SIGNATURE AS WELL, AND WE 3480 02:18:51,389 --> 02:18:54,859 ALSO OBSERVED THAT, BUT SOME OF 3481 02:18:54,926 --> 02:18:57,262 THOSE GENES ARE ALSO PICKED UP 3482 02:18:57,328 --> 02:18:58,997 BY EXPERIMENTAL STUDIES, SO THEY 3483 02:18:59,064 --> 02:19:08,239 ARE GOOD CANDIDATES TO INDEED BE 3484 02:19:08,306 --> 02:19:09,407 DRIVERS OF THOSE MUTAGENIC 3485 02:19:09,474 --> 02:19:09,841 CAUSES. 3486 02:19:09,908 --> 02:19:11,509 LAST I WANT TO MENTION I'M NOT 3487 02:19:11,576 --> 02:19:13,712 GOING TO GO INTO THIS AT ALL. 3488 02:19:13,778 --> 02:19:15,680 WE ALSO LOOKED A INTERACTION 3489 02:19:15,747 --> 02:19:18,516 BETWEEN DNA DAMAGE AND REPAIR 3490 02:19:18,583 --> 02:19:21,352 NAMELY WE SEE THAT REALLY WHAT 3491 02:19:21,419 --> 02:19:24,322 COMES AT THE END AS A MUTATION 3492 02:19:24,389 --> 02:19:26,391 IS PROPOSITION OF TWO PROCESSES, 3493 02:19:26,458 --> 02:19:30,862 ONE IS THAT WE HAVE WHATEVER DNA 3494 02:19:30,929 --> 02:19:33,832 DAMAGE HAPPEN, BUT ALSO WHATEVER 3495 02:19:33,898 --> 02:19:35,900 WE MAY HAVE DEFICIENCY IN DNA 3496 02:19:35,967 --> 02:19:37,569 REPAIR, AND THOSE TWO PROCESSES 3497 02:19:37,635 --> 02:19:40,739 ARE NOT INDEPENDENT AND WE NEED 3498 02:19:40,805 --> 02:19:43,041 MODELS SO WE'VE BEEN LOOKING AT 3499 02:19:43,108 --> 02:19:44,109 THAT AS WELL. 3500 02:19:44,175 --> 02:19:49,481 SO I'LL SKIP THIS ONE. 3501 02:19:49,547 --> 02:19:53,852 AND JUST TO -- I THINK A GOOD 3502 02:19:53,918 --> 02:19:58,156 TIME TO SUMMARIZE. 3503 02:19:58,223 --> 02:19:59,791 I PROPOSE DISCUSS ALGORITHMIC 3504 02:19:59,858 --> 02:20:04,829 METHODS TO STUDY INTERACTIONS OF 3505 02:20:04,896 --> 02:20:05,897 SIGNATURES, VARIOUS PROCESSES OF 3506 02:20:05,964 --> 02:20:09,100 GENE EXPRESSION. 3507 02:20:09,167 --> 02:20:11,970 HERE WE SHOW HOW SIGNATURES CAN 3508 02:20:12,036 --> 02:20:19,844 BE COMBINED AND HELP US 3509 02:20:19,911 --> 02:20:21,579 UNDERSTAND IMPACT OF ENVIRONMENT 3510 02:20:21,646 --> 02:20:25,183 ON SHOW OF INTEREST, HOW THEY 3511 02:20:25,250 --> 02:20:28,153 CAN BE USED TO SEE RELATIONSHIP 3512 02:20:28,219 --> 02:20:30,021 BETWEEN CANCER DRIVER MUTATIONS 3513 02:20:30,088 --> 02:20:32,190 AND IMMERSIONS OF PARTICULAR 3514 02:20:32,257 --> 02:20:33,024 MUTATIONAL PROCESSES. 3515 02:20:33,091 --> 02:20:35,360 THERE IS ALSO INTEREST IN 3516 02:20:35,426 --> 02:20:38,997 UNDERSTANDING HOW THOSE 3517 02:20:39,063 --> 02:20:41,833 MUTATIONAL PROCESSES APPEAR IN 3518 02:20:41,900 --> 02:20:45,670 CANCER EVOLUTION, SOMETHING 3519 02:20:45,737 --> 02:20:49,841 WE'RE INTERESTED, BUT AREAS 3520 02:20:49,908 --> 02:20:51,576 TO -- ALSO WHAT I MENTION IS 3521 02:20:51,643 --> 02:20:55,713 UNDERSTANDING AND DEVELOP MORE 3522 02:20:55,780 --> 02:20:57,715 COMPLICATED MODEL THAT WILL 3523 02:20:57,782 --> 02:21:00,418 CAPTURE INTERACTION BETWEEN DNA 3524 02:21:00,485 --> 02:21:01,419 DAMAGE AND REPAIR. 3525 02:21:01,486 --> 02:21:03,721 IN CONCLUSION I HOPE I CONVINCED 3526 02:21:03,788 --> 02:21:08,393 YOU THAT THE JOINT ANALYSIS OF 3527 02:21:08,459 --> 02:21:13,898 DATA BRINGS US AN IMPORTANT AND 3528 02:21:13,965 --> 02:21:14,732 PERHAPS SURPRISING INFORMATION 3529 02:21:14,799 --> 02:21:15,967 SO SOMETIMES IF YOU THINK ABOUT 3530 02:21:16,034 --> 02:21:19,604 IT, YOU HAVE A QUESTION, YOU MAY 3531 02:21:19,671 --> 02:21:22,540 DIG IN AND FIND THE DATA ALREADY 3532 02:21:22,607 --> 02:21:24,309 COLLECTED, AT LEAST CAN GIVE YOU 3533 02:21:24,375 --> 02:21:25,910 THE FIRST DIG INTO THE QUESTION 3534 02:21:25,977 --> 02:21:27,712 THAT THIS FIRST SET OF 3535 02:21:27,779 --> 02:21:31,115 HYPOTHESIS AS YOU CAN SEE IN OUR 3536 02:21:31,182 --> 02:21:34,485 UTILIZATION OF NORMAL TISSUE IN 3537 02:21:34,552 --> 02:21:39,657 CANCER STUDIES TO UNDERSTAND HOW 3538 02:21:39,724 --> 02:21:41,693 SMOKING CAUSES TISSUE 3539 02:21:41,759 --> 02:21:42,260 REMODELING. 3540 02:21:42,327 --> 02:21:45,296 AND OUR CURRENT WORK WE STUDY 3541 02:21:45,363 --> 02:21:48,266 MUTATIONAL SIGNATURE IN TERMS OF 3542 02:21:48,333 --> 02:21:49,801 DRUG RESPONSE, ESPECIALLY IN 3543 02:21:49,868 --> 02:21:55,373 IMMUNOTHERAPY, AND ALSO LOOKING 3544 02:21:55,440 --> 02:21:57,775 AT BEYOND MODELS THAT I 3545 02:21:57,842 --> 02:22:03,248 PRESENTED, ALSO IN MACHINE 3546 02:22:03,314 --> 02:22:06,584 LEARNING APPROACHES, ESPECIALLY 3547 02:22:06,651 --> 02:22:08,186 IN DRUG RESPONSE, TRYING TO 3548 02:22:08,253 --> 02:22:11,022 UNDERSTAND WHETHER WE CAN TAKE 3549 02:22:11,089 --> 02:22:13,224 THIS DATA, USING MATHEMATICAL 3550 02:22:13,291 --> 02:22:15,093 METHODS TRY TO IDENTIFY WHETHER 3551 02:22:15,159 --> 02:22:16,928 THERE'S SOME PREFERENTIAL ORDER 3552 02:22:16,995 --> 02:22:23,835 OF SIGNATURES AS THEY APPEAR AS 3553 02:22:23,902 --> 02:22:24,702 CANCER DEVELOPS. 3554 02:22:24,769 --> 02:22:29,073 AND I'D LIKE TO AGAIN 3555 02:22:29,140 --> 02:22:30,275 ACKNOWLEDGE MY LAB MEMBERS, NET 3556 02:22:30,341 --> 02:22:36,614 WOK OF GENES AND SIGNATURES, JAN 3557 02:22:36,681 --> 02:22:40,218 WAS INVOLVED IN THIS STUDY OF 3558 02:22:40,285 --> 02:22:45,290 INTERACTION BETWEEN DNA DAMAGE 3559 02:22:45,356 --> 02:22:48,459 AND REPAIR. 3560 02:22:48,526 --> 02:22:51,095 SHE IS LOOKING INTO TUMOR 3561 02:22:51,162 --> 02:22:57,302 EVOLUTION, SINGLE CELL DATA, AND 3562 02:22:57,368 --> 02:23:02,907 ERMIN LOOKING AT WORK ON THIS 3563 02:23:02,974 --> 02:23:05,176 RELATIONSHIP BETWEEN SMOKING AND 3564 02:23:05,243 --> 02:23:07,111 CELL TYPE COMPOSITION, REFINING 3565 02:23:07,178 --> 02:23:12,183 METHOD FOR CELL TYPE 3566 02:23:12,250 --> 02:23:13,384 COMPOSITION. 3567 02:23:13,451 --> 02:23:14,585 AND ZIYNET JOINED RECENTLY, 3568 02:23:14,652 --> 02:23:16,020 INTERESTED IN APPLYING MACHINE 3569 02:23:16,087 --> 02:23:20,625 LEARNING TO SEE HOW WE CAN 3570 02:23:20,692 --> 02:23:22,260 COMBINE MUTATIONAL SIGNATURES, 3571 02:23:22,327 --> 02:23:26,864 CANCER DRIVERS, GENE EXPRESSION, 3572 02:23:26,931 --> 02:23:30,368 AND OTHER DATA TO STUDY DIRECT 3573 02:23:30,435 --> 02:23:32,203 RESPONSE ESPECIALLY IN 3574 02:23:32,270 --> 02:23:32,770 IMMUNOTHERAPY. 3575 02:23:32,837 --> 02:23:35,707 I WOULD LIKE TO ACKNOWLEDGE THE 3576 02:23:35,773 --> 02:23:40,178 GROUP MEMBERS THAT CONTRIBUTED 3577 02:23:40,244 --> 02:23:48,286 TO THIS WORK, OPTIMALIZE RNA 3578 02:23:48,353 --> 02:23:53,257 VACCINES, REBECCA IN START-UP 3579 02:23:53,324 --> 02:23:56,961 COMPANY, ARIELLA, NOW A GRADUATE 3580 02:23:57,028 --> 02:23:58,062 STUDENT, AND DAMIAN AN 3581 02:23:58,129 --> 02:23:59,931 INVESTIGATOR IN WARSAW AND MY 3582 02:23:59,998 --> 02:24:00,264 COLLABORATORS. 3583 02:24:00,331 --> 02:24:03,101 THANK YOU SO MUCH FOR YOUR 3584 02:24:03,167 --> 02:24:03,735 ATTENTION. 3585 02:24:03,801 --> 02:24:04,102 >> OKAY. 3586 02:24:04,168 --> 02:24:06,270 WONDERFUL. 3587 02:24:06,337 --> 02:24:07,405 THANK YOU SO MUCH FOR SHARING 3588 02:24:07,472 --> 02:24:09,674 YOUR WORK WITH US. 3589 02:24:09,741 --> 02:24:12,310 IT'S QUITE AN IMPRESSIVE BODY OF 3590 02:24:12,377 --> 02:24:12,510 WORK. 3591 02:24:12,577 --> 02:24:15,913 I'D LIKE TO WELCOME TWO OF OUR 3592 02:24:15,980 --> 02:24:19,517 BOARD MEMBERS TO FACILITATE THE 3593 02:24:19,584 --> 02:24:23,154 CONVERSATION WITH YOU. 3594 02:24:23,221 --> 02:24:29,961 I'D LIKE TO ASK DR. OGUNYEMI AND 3595 02:24:30,028 --> 02:24:32,563 DR. NANCY SMIDER TO JOIN THE 3596 02:24:32,630 --> 02:24:34,098 CONVERSATION. 3597 02:24:34,165 --> 02:24:34,399 >> THANKS. 3598 02:24:34,465 --> 02:24:37,168 THIS IS NANCY SMIDER. 3599 02:24:37,235 --> 02:24:40,338 THANK YOU FOR YOUR AMAZING 3600 02:24:40,405 --> 02:24:41,105 PRESENTATION. 3601 02:24:41,172 --> 02:24:43,207 I PERSONALLY FIND YOUR WORK 3602 02:24:43,274 --> 02:24:44,709 REALLY INTERESTING AND ENGAGING. 3603 02:24:44,776 --> 02:24:47,245 I ALSO WANTED TO THANK YOU FOR 3604 02:24:47,311 --> 02:24:48,780 PRESENTATION THAT MADE YOUR WORK 3605 02:24:48,846 --> 02:24:51,416 ACCESSIBLE TO THOSE OF US NOT 3606 02:24:51,482 --> 02:24:53,818 DEEP SPECIALISTS IN THIS AREA 3607 02:24:53,885 --> 02:24:54,118 WHATSOEVER. 3608 02:24:54,185 --> 02:24:57,321 I DO HAVE A FEW QUESTIONS FOR 3609 02:24:57,388 --> 02:25:02,026 YOU, BEFORE I ASK MINE I'D LIKE 3610 02:25:02,093 --> 02:25:03,761 TO INVITE LOLA TO INTRODUCE 3611 02:25:03,828 --> 02:25:05,163 HERSELF, MAKE COMMENTS AND ALSO 3612 02:25:05,229 --> 02:25:07,265 TO OPEN IT UP TO ANY QUESTIONS 3613 02:25:07,331 --> 02:25:16,040 FROM THE GROUP FIRST AS WELL. 3614 02:25:16,107 --> 02:25:17,241 >> I FOUND YOUR WORK 3615 02:25:17,308 --> 02:25:17,542 INTERESTING. 3616 02:25:17,608 --> 02:25:18,643 I HAVE QUESTIONS BUT AS NANCY 3617 02:25:18,709 --> 02:25:20,311 SAID WE CAN OPEN TO THE GROUP 3618 02:25:20,378 --> 02:25:21,412 FIRST AND THEN ASK OUR 3619 02:25:21,479 --> 02:25:21,679 QUESTIONS. 3620 02:25:21,746 --> 02:25:27,852 ARE THERE ANY QUESTIONS FROM THE 3621 02:25:27,919 --> 02:25:32,423 GROUP? 3622 02:25:32,490 --> 02:25:34,859 DR. CIMINO. 3623 02:25:34,926 --> 02:25:37,261 >> I'M WONDERING HOW -- YOU 3624 02:25:37,328 --> 02:25:40,098 KNOW, WHAT POPULATIONS WERE THAT 3625 02:25:40,164 --> 02:25:40,965 WERE SAMPLED, WHETHER THERE 3626 02:25:41,032 --> 02:25:43,067 MIGHT HAVE BEEN BIAS IN DATA 3627 02:25:43,134 --> 02:25:44,836 COLLECTION, YOU KNOW, CONCERNED 3628 02:25:44,902 --> 02:25:47,538 ABOUT THAT THESE DAYS? 3629 02:25:47,605 --> 02:25:51,476 >> YES, AND THIS IS EXCELLENT 3630 02:25:51,542 --> 02:25:51,742 QUESTION. 3631 02:25:51,809 --> 02:25:59,817 AND THERE'S DEFINITELY BIAS IN 3632 02:25:59,884 --> 02:26:02,987 THE POPULATION. 3633 02:26:03,054 --> 02:26:05,189 OKAY, WE DON'T ALWAYS KNOW THE 3634 02:26:05,256 --> 02:26:09,494 DISTRIBUTION OF THE POPULATION. 3635 02:26:09,560 --> 02:26:11,762 SOMETIMES WE DO, AND FOR SOME 3636 02:26:11,829 --> 02:26:17,435 STUDY WE DO, WE'RE AWARE THAT 3637 02:26:17,502 --> 02:26:18,002 EUROPEAN POPULATION IS 3638 02:26:18,069 --> 02:26:18,369 OVERREPRESENTED. 3639 02:26:18,436 --> 02:26:19,871 THIS IS REALLY IMPORTANT IN THIS 3640 02:26:19,937 --> 02:26:28,279 TYPE OF STUDIES BECAUSE WE KNOW 3641 02:26:28,346 --> 02:26:30,381 EVEN FROM EUROPEAN POPULATIONS 3642 02:26:30,448 --> 02:26:33,317 HOW NON-UNIFORM CANCER DRIVERS 3643 02:26:33,384 --> 02:26:36,053 ARE, ASHKENAZI JEWISH HAVE MORE 3644 02:26:36,120 --> 02:26:37,622 BRCA MUTATION, SOMETIMES THERE 3645 02:26:37,688 --> 02:26:42,760 ARE MORE DRIVER MUTATIONS THAT 3646 02:26:42,827 --> 02:26:43,261 AFFECT OTHER POPULATION. 3647 02:26:43,327 --> 02:26:48,432 I THINK THIS IS IMPORTANT 3648 02:26:48,499 --> 02:26:48,833 QUESTION. 3649 02:26:48,900 --> 02:26:50,535 AND THE DATA HAVE BEEN 3650 02:26:50,601 --> 02:26:53,804 COLLECTED, YOU KNOW, YEARS AGO, 3651 02:26:53,871 --> 02:26:57,842 AND I THINK NOW WE'RE TRYING TO 3652 02:26:57,909 --> 02:27:04,415 FILL THIS GAP AND BE MORE 3653 02:27:04,482 --> 02:27:05,850 UNBIASED IN THE PATIENT 3654 02:27:05,917 --> 02:27:06,150 POPULATION. 3655 02:27:06,217 --> 02:27:11,222 BUT YES, THIS IS AN ISSUE THAT 3656 02:27:11,289 --> 02:27:12,290 NEEDS TO BE ADDRESSED, LOOKS 3657 02:27:12,356 --> 02:27:21,933 LIKE WE BEGIN TO ADDRESS IT. 3658 02:27:21,999 --> 02:27:27,238 AS A COMMUNITY. 3659 02:27:29,207 --> 02:27:29,473 >> RICHARD? 3660 02:27:29,540 --> 02:27:31,042 >> THANKS, THAT WAS A REALLY 3661 02:27:31,108 --> 02:27:32,777 INTERESTING PRESENTATION. 3662 02:27:32,843 --> 02:27:34,412 I'M WONDERING CAN THESE 3663 02:27:34,478 --> 02:27:36,380 MUTATIONAL SIGNATURES BE USED TO 3664 02:27:36,447 --> 02:27:37,615 SOMEHOW DISTINGUISH BETWEEN 3665 02:27:37,682 --> 02:27:48,226 DRIVER AND PASSENGER MUTATIONS? 3666 02:27:50,728 --> 02:27:55,533 IS THAT POSSIBLE? 3667 02:27:55,600 --> 02:27:55,800 >> HMM. 3668 02:27:55,866 --> 02:27:57,168 IT ANTI-BEEN USED THAT WAY, 3669 02:27:57,235 --> 02:28:01,305 LET'S PUT IT THIS WAY. 3670 02:28:01,372 --> 02:28:04,609 IT'S ASSUMED MUTATIONAL 3671 02:28:04,675 --> 02:28:06,210 SIGNATURE ARE REALLY COMPOSED OF 3672 02:28:06,277 --> 02:28:07,678 (INDISCERNIBLE) MUTATIONS. 3673 02:28:07,745 --> 02:28:12,416 THEY CAN BE USED FOR, TO SEE AND 3674 02:28:12,483 --> 02:28:15,453 THIS IS SUCCESSFULLY DONE IN NOT 3675 02:28:15,519 --> 02:28:19,924 TOO MANY CASES, IS THAT THERE'S 3676 02:28:19,991 --> 02:28:23,127 CERTAIN DRIVER MUTATIONS THAT 3677 02:28:23,194 --> 02:28:29,000 ARE OVERREPRESENTED IN THE 3678 02:28:29,066 --> 02:28:29,300 POPULATIONS. 3679 02:28:29,367 --> 02:28:39,543 FOR EXAMPLE, IT'S SHOWN APOBEC 3680 02:28:39,610 --> 02:28:41,946 HAVE A PARTICULAR MUTATION, THIS 3681 02:28:42,013 --> 02:28:44,915 IS UNDERSTOOD THAT THIS IS 3682 02:28:44,982 --> 02:28:48,386 BECAUSE APOBEC IS AN ENZYME THAT 3683 02:28:48,452 --> 02:28:53,124 IS ACTIVATED DURING IMMUNE 3684 02:28:53,190 --> 02:28:56,093 RESPONSE, ACTUALLY THE CONCEPT 3685 02:28:56,160 --> 02:29:01,832 THAT IT'S RELATED TO IS VIRAL OR 3686 02:29:01,899 --> 02:29:06,637 IN ORIGIN MAY BE TARGETED, YOU 3687 02:29:06,704 --> 02:29:08,939 KNOW, TO MUTATION, TARGETED BY 3688 02:29:09,006 --> 02:29:09,707 APOBEC. 3689 02:29:09,774 --> 02:29:11,575 BUT OTHER THAN STATISTICAL, YOU 3690 02:29:11,642 --> 02:29:14,845 KNOW, REALLY NEED TO HAVE EVEN 3691 02:29:14,912 --> 02:29:17,581 CANCER TUMOR TO SEE WHERE 3692 02:29:17,648 --> 02:29:20,217 MUTATION HAPPEN BECAUSE 3693 02:29:20,284 --> 02:29:22,253 OTHERWISE MUTATION BE DIFFERENT 3694 02:29:22,320 --> 02:29:26,791 IN EVERY INDIVIDUAL CELL TYPE, 3695 02:29:26,857 --> 02:29:32,163 BASED ON FREQUENCY I DON'T THINK 3696 02:29:32,229 --> 02:29:35,266 SO, THAT HELPING TO IDENTIFY. 3697 02:29:38,135 --> 02:29:38,369 >> OKAY. 3698 02:29:38,436 --> 02:29:40,638 I DON'T SEE ANY OTHER HANDS UP 3699 02:29:40,705 --> 02:29:42,973 SO I'LL ASK MY QUESTION. 3700 02:29:43,040 --> 02:29:43,741 THAT'S SOMETHING THAT 3701 02:29:43,808 --> 02:29:45,076 PARTICULARLY WAS OF INTEREST TO 3702 02:29:45,142 --> 02:29:45,609 ME. 3703 02:29:45,676 --> 02:29:47,378 SO I WAS WONDERING IF YOU COULD 3704 02:29:47,445 --> 02:29:48,579 DESCRIBE A LITTLE BIT MORE 3705 02:29:48,646 --> 02:29:50,214 ESPECIALLY FOR THOSE THAT DON'T 3706 02:29:50,281 --> 02:29:52,416 HAVE A BACKGROUND IN THIS, THE 3707 02:29:52,483 --> 02:29:56,787 ROLE THAT YOU SEE MUTATIONAL 3708 02:29:56,854 --> 02:30:01,892 SIGNATURES PLAYING IN ASSESSING 3709 02:30:01,959 --> 02:30:04,662 IMMUNOTHERAPY STRATEGIES. 3710 02:30:04,729 --> 02:30:05,429 >> OKAY. 3711 02:30:05,496 --> 02:30:08,532 SO, NOT TOO MANY METHODS TO 3712 02:30:08,599 --> 02:30:11,469 APPROACH AND TO UNDERSTAND WHICH 3713 02:30:11,535 --> 02:30:15,072 PATIENT WILL RESPOND TO 3714 02:30:15,139 --> 02:30:15,406 IMMUNOTHERAPY. 3715 02:30:15,473 --> 02:30:18,209 ONE, FOR EXAMPLE, ONE KNOWN 3716 02:30:18,275 --> 02:30:23,381 FACTOR IS THAT THE NUMBER OF 3717 02:30:23,447 --> 02:30:25,783 SOMATIC MUTATIONS IS A RESIDENT 3718 02:30:25,850 --> 02:30:27,752 PREDICTOR OF THE RESPONSE, AND 3719 02:30:27,818 --> 02:30:29,820 OF COURSE, YOU KNOW, THE NUMBER 3720 02:30:29,887 --> 02:30:32,690 OF SOMATIC MUTATIONS NOW WE SAY, 3721 02:30:32,757 --> 02:30:34,592 OKAY, DOESN'T MATTER WHETHER THE 3722 02:30:34,658 --> 02:30:38,696 SOMATIC MUTATION, PERHAPS IT 3723 02:30:38,763 --> 02:30:40,231 MATTERS SOMATIC MUTATION, 3724 02:30:40,297 --> 02:30:42,133 SOMATIC SIGNATURE, NOW 3725 02:30:42,199 --> 02:30:44,468 APPRECIATED THERE'S AN 3726 02:30:44,535 --> 02:30:47,071 ASSOCIATION BETWEEN STRENGTH OF 3727 02:30:47,138 --> 02:30:51,742 APOBEC MUTATION OF SIGNATURE AND 3728 02:30:51,809 --> 02:30:53,811 RESPONSE TO THERAPY IN SEVERAL 3729 02:30:53,878 --> 02:30:58,115 CANCER TYPES. 3730 02:30:58,182 --> 02:31:01,519 THERE'S ALSO AN INTERESTING -- 3731 02:31:01,585 --> 02:31:06,524 TO LOOK LIKE IT'S BEEN EXPOSURE 3732 02:31:06,590 --> 02:31:11,095 TO SMOKING SIGNATURES ACTUALLY, 3733 02:31:11,162 --> 02:31:14,632 CORRELATED WITH THE RESPONSE TO 3734 02:31:14,698 --> 02:31:15,065 IMMUNOTHERAPY. 3735 02:31:15,132 --> 02:31:17,701 AND BY AGGREGATING THE DATA, WE 3736 02:31:17,768 --> 02:31:20,738 CAN ALSO SEE THAT, AGAIN, 3737 02:31:20,805 --> 02:31:21,939 LOOKING AT THIS, SOMETHING 3738 02:31:22,006 --> 02:31:24,041 ACTUALLY REVIEWER POINTED TO US 3739 02:31:24,108 --> 02:31:33,117 WHEN LOOKING AT THE RELATIONSHIP 3740 02:31:33,184 --> 02:31:37,721 BETWEEN GENE EXPRESSION AND 3741 02:31:37,788 --> 02:31:40,658 SIGNATURE, SMOKING SIGNATURE, 3742 02:31:40,724 --> 02:31:43,527 DON'T WE SEE RELATIONSHIP 3743 02:31:43,594 --> 02:31:45,062 BETWEEN SMOKING SIGNATURES AND 3744 02:31:45,129 --> 02:31:47,364 EXPRESSION OF THE GENES INVOLVED 3745 02:31:47,431 --> 02:31:48,899 IN IMMUNE RESPONSE. 3746 02:31:48,966 --> 02:31:54,038 WE DID SEE THAT KIND OF EXPLAIN 3747 02:31:54,104 --> 02:32:01,479 WHY SMOKING MAY, YOU KNOW, THE 3748 02:32:01,545 --> 02:32:04,982 SMOKING MIGHT INCREASE 3749 02:32:05,049 --> 02:32:06,717 IMPROVING -- THAT -- THAT 3750 02:32:06,784 --> 02:32:09,353 PATIENTS WHOSE CANCER IS DUE TO 3751 02:32:09,420 --> 02:32:10,688 SMOKING MAY RESPOND TO 3752 02:32:10,754 --> 02:32:11,422 IMMUNOTHERAPY AS OPPOSED TO 3753 02:32:11,489 --> 02:32:13,290 CANCER THAT IS NOT DUE TO 3754 02:32:13,357 --> 02:32:15,493 SMOKING BECAUSE THERE'S A 3755 02:32:15,559 --> 02:32:17,361 RELATIONSHIP BETWEEN SMOKING AND 3756 02:32:17,428 --> 02:32:18,762 INCREASE OF EXPRESSION OF 3757 02:32:18,829 --> 02:32:20,431 PARTICULAR GENES THAT RESPOND TO 3758 02:32:20,498 --> 02:32:22,800 THERAPY, SO THIS IS -- THOSE ARE 3759 02:32:22,867 --> 02:32:25,336 RIGHT NOW WE HAVE LIKE SIMPLE 3760 02:32:25,402 --> 02:32:26,770 EXAMPLES, INDIVIDUAL EXAMPLES. 3761 02:32:26,837 --> 02:32:32,676 WHAT WE HOPE IS TO COLLECT 3762 02:32:32,743 --> 02:32:35,613 ENOUGH DATA, CONNECTED WITH THE 3763 02:32:35,679 --> 02:32:38,249 APPROACHES TO SEE WHETHER WE CAN 3764 02:32:38,315 --> 02:32:39,450 BUILD A PREDICTIVE MODEL. 3765 02:32:39,517 --> 02:32:44,822 WHAT WOULD BE REALLY INTERESTING 3766 02:32:44,889 --> 02:32:47,758 IF WE CAN COLLECT, YOU KNOW, 3767 02:32:47,825 --> 02:32:49,827 USING THE DATA OFTEN USED IN 3768 02:32:49,894 --> 02:32:52,563 CLINICS SO SO CALLED IMPACT DATA 3769 02:32:52,630 --> 02:32:56,066 WHICH WE HAVE A LOT OF PATIENTS 3770 02:32:56,133 --> 02:32:58,202 THAT FOR WHICH THIS DATA IS 3771 02:32:58,269 --> 02:32:59,803 PROVIDED AND SEE WHETHER EVEN IF 3772 02:32:59,870 --> 02:33:01,438 IT'S A SMALL NUMBER OF GENES 3773 02:33:01,505 --> 02:33:06,911 EVEN WE HAVE SMALL NUMBER OF 3774 02:33:06,977 --> 02:33:09,413 MUTATIONS THAT WE CAN USE, 3775 02:33:09,480 --> 02:33:10,281 COLLECT THIS DATA TOGETHER, SO 3776 02:33:10,347 --> 02:33:12,583 THAT WE CAN ALSO GET SOME 3777 02:33:12,650 --> 02:33:13,918 INFORMATION EVEN FROM THE 3778 02:33:13,984 --> 02:33:17,087 SMALLER SAMPLE. 3779 02:33:17,154 --> 02:33:19,723 THIS IS HOW WE SEE HOW WE CAN 3780 02:33:19,790 --> 02:33:24,428 USE THIS TO OUR SIGNAL THERAPY, 3781 02:33:24,495 --> 02:33:28,399 BUT ALSO FOR ALL THE MUTATION 3782 02:33:28,465 --> 02:33:30,034 SIGNATURES OCCUR BECAUSE THERE'S 3783 02:33:30,100 --> 02:33:31,902 DAMAGE IN DNA REPAIR. 3784 02:33:31,969 --> 02:33:35,706 AND WE LIKE THE EXAMPLE OF THE 3785 02:33:35,773 --> 02:33:38,008 BREAST CANCER. 3786 02:33:38,075 --> 02:33:40,978 AND YET THERE'S DAMAGE DNA 3787 02:33:41,045 --> 02:33:43,180 REPAIR, IT'S MULTIPLYING AND WE 3788 02:33:43,247 --> 02:33:43,847 HAVE CANCER. 3789 02:33:43,914 --> 02:33:48,218 SO THE IDEA OF THEM NOW HOW WE 3790 02:33:48,285 --> 02:33:50,955 CAN -- IF WE UNDERSTAND WHAT 3791 02:33:51,021 --> 02:33:53,023 DAMAGE IS RELATED TO MUTATIONAL 3792 02:33:53,090 --> 02:33:55,893 SIGNATURE, WE USE THE CELL 3793 02:33:55,960 --> 02:33:58,062 CONCEPT OF EPISTASIS, TRY TO SEE 3794 02:33:58,128 --> 02:34:00,230 WHICH IS THE DNA REPAIR PATHWAY 3795 02:34:00,297 --> 02:34:04,501 THAT IS ABLE TO BYPASS THE ONES 3796 02:34:04,568 --> 02:34:06,270 DAMAGED, DAMAGE PATHWAYS, THAT'S 3797 02:34:06,337 --> 02:34:08,339 ANOTHER WAY OF HOPING THAT WE 3798 02:34:08,405 --> 02:34:11,842 CAN -- IF WE CAN DO THAT, THEN 3799 02:34:11,909 --> 02:34:17,881 WE HAVE TARGET OF THE CELLS, 3800 02:34:17,948 --> 02:34:26,523 CANCER CELL, AS OPPOSED TO 3801 02:34:26,590 --> 02:34:28,292 ORGANISM, TWO MAIN TO IMPROVE 3802 02:34:28,359 --> 02:34:28,525 THERAPY. 3803 02:34:28,592 --> 02:34:34,398 >> THANK YOU. 3804 02:34:34,465 --> 02:34:38,035 >> I'LL ASK ONE OF MY QUESTIONS. 3805 02:34:38,102 --> 02:34:40,337 IT'S RELATED. 3806 02:34:40,404 --> 02:34:42,172 SO, STEPPING OUTSIDE OF YOUR 3807 02:34:42,239 --> 02:34:44,375 DEEP DAY-TO-DAY WORK YOU DO, 3808 02:34:44,441 --> 02:34:46,143 WHAT WOULD YOUR RECOMMENDATIONS 3809 02:34:46,210 --> 02:34:54,218 BE ON HOW TO INFUSE THE USE OF 3810 02:34:54,284 --> 02:34:54,985 MUTATIONAL SIGNATURES FOR 3811 02:34:55,052 --> 02:34:55,753 DIAGNOSTIC PREVENTION AND 3812 02:34:55,819 --> 02:34:57,254 TREATMENT IN PRACTICE DOMAIN AND 3813 02:34:57,321 --> 02:35:03,494 HOW CAN WE ACCELERATE THAT? 3814 02:35:03,560 --> 02:35:06,030 >> SO I THINK THIS IS BEING DONE 3815 02:35:06,096 --> 02:35:12,703 BY VARIOUS GROUP REALLY, MAKE 3816 02:35:12,770 --> 02:35:15,639 SURE THAT WE DO SEQUENCE A LOT 3817 02:35:15,706 --> 02:35:16,740 OF CANCER GENOMES AND COLLECT A 3818 02:35:16,807 --> 02:35:19,043 LOT OF INFORMATION THAT SHOULD 3819 02:35:19,109 --> 02:35:24,415 INCLUDE EXACTLY THE LOCATION, 3820 02:35:24,481 --> 02:35:26,116 ETHNICITY, DIET, AND USAGE OF 3821 02:35:26,183 --> 02:35:30,554 ANY DRUGS, BECAUSE ALL OF THOSE, 3822 02:35:30,621 --> 02:35:34,291 EACH OF THOSE CAN INVOLVE A 3823 02:35:34,358 --> 02:35:39,630 SPECIFIC PROCESS. 3824 02:35:39,697 --> 02:35:41,065 THE EXAMPLE, MUTATIONAL 3825 02:35:41,131 --> 02:35:44,902 SIGNATURES, BE HELPFUL TO 3826 02:35:44,968 --> 02:35:51,875 IDENTIFY SYSTEM CHANGE IN -- 3827 02:35:51,942 --> 02:35:55,946 LIKE USAGE OF SYSTEM, NOT SO 3828 02:35:56,013 --> 02:36:02,619 MUCH DRIVE BUT ACCESS SOME TEA 3829 02:36:02,686 --> 02:36:04,254 OR HERBS CAUSES PARTICULAR 3830 02:36:04,321 --> 02:36:05,255 MUTAGENIC PROCESS, SO IT'S 3831 02:36:05,322 --> 02:36:07,758 REALLY IMPORTANT TO KNOW 3832 02:36:07,825 --> 02:36:10,160 PEOPLE'S HABITS, PEOPLE'S 3833 02:36:10,227 --> 02:36:10,994 ETHNICITY, PEOPLE'S GEOGRAPHIC 3834 02:36:11,061 --> 02:36:12,896 LOCATION, SO THAT WE CAN 3835 02:36:12,963 --> 02:36:15,866 WHENEVER WE SEE A NEW MUTAGENIC 3836 02:36:15,933 --> 02:36:19,770 PROCESS EMERGING WE CAN LINK IT 3837 02:36:19,837 --> 02:36:22,639 TO POTENTIAL CAUSES. 3838 02:36:22,706 --> 02:36:24,708 AND, YOU KNOW, IF THIS CAUSES 3839 02:36:24,775 --> 02:36:26,210 POPULATION WE NEED TO GIVE 3840 02:36:26,276 --> 02:36:32,349 POPULATION NEED TO BE TESTED FOR 3841 02:36:32,416 --> 02:36:33,684 EMERGENCE OF MUTATION 3842 02:36:33,751 --> 02:36:36,286 SIGNATURES, EMERGENCE OF CANCER, 3843 02:36:36,353 --> 02:36:39,256 IF THIS IS TO DIET, IF WE CAN 3844 02:36:39,323 --> 02:36:41,558 PINPOINT WE CAN ELIMINATE, I 3845 02:36:41,625 --> 02:36:44,828 SHOULD SAY, GIVEN, YOU KNOW, 3846 02:36:44,895 --> 02:36:47,464 MUTAGEN FROM DIET. 3847 02:36:47,531 --> 02:36:50,501 THIS IS LIKE -- I THINK THIS IS 3848 02:36:50,567 --> 02:36:54,805 A VERY IMPORTANT AND POTENTIALLY 3849 02:36:54,872 --> 02:37:01,245 STRONG INFORMATION ABOUT HOW 3850 02:37:01,311 --> 02:37:03,347 MUTAGENIC PROCESS CAN DIFFER IN 3851 02:37:03,413 --> 02:37:09,319 INDIVIDUAL GROUPS AND ON MANY 3852 02:37:09,386 --> 02:37:10,020 DIFFERENT LEVELS. 3853 02:37:10,087 --> 02:37:12,956 >> THANK YOU. 3854 02:37:13,023 --> 02:37:23,333 >> DO WE HAVE OTHER QUESTIONS? 3855 02:37:23,400 --> 02:37:30,140 >> SO BESIDES CANCER DO YOU SEE 3856 02:37:30,207 --> 02:37:32,643 ANY POSSIBLE APPLICATION, EVEN 3857 02:37:32,709 --> 02:37:35,179 IN THE NEAR TERM, ABOUT USING 3858 02:37:35,245 --> 02:37:36,914 THESE METHODS FOR RARE DISEASES 3859 02:37:36,980 --> 02:37:44,488 AND SOME OF THE UNDIAGNOSED 3860 02:37:44,555 --> 02:37:44,788 DISEASES? 3861 02:37:44,855 --> 02:37:47,324 >> SO, ONE IMPORTANT -- SO THIS 3862 02:37:47,391 --> 02:37:51,461 REASON WHY THE PROCESS, 3863 02:37:51,528 --> 02:37:54,431 MUTATIONAL SIGNATURE RESEARCH IS 3864 02:37:54,498 --> 02:37:56,166 EVOLVING MOSTLY AROUND CANCER, 3865 02:37:56,233 --> 02:37:58,936 IF WE DO NOT -- SO IF WE 3866 02:37:59,002 --> 02:38:00,571 DON'T -- IF WE GO OUTSIDE OF 3867 02:38:00,637 --> 02:38:02,873 CANCER TO DIFFERENT TYPE OF 3868 02:38:02,940 --> 02:38:04,842 TISSUE, IT'S VERY DIFFICULT TO 3869 02:38:04,908 --> 02:38:06,643 CALL MUTATIONS. 3870 02:38:06,710 --> 02:38:12,249 SO WE WILL NEED TO MOVE 3871 02:38:12,316 --> 02:38:13,684 SINGLE-CELL RESOLUTION. 3872 02:38:13,750 --> 02:38:17,955 NOW WITH SINGLE CELL TECHNOLOGY, 3873 02:38:18,021 --> 02:38:23,427 WE CAN REALLY SEE WHAT 3874 02:38:23,493 --> 02:38:25,495 MUTATIONAL PROCESSES ARE PRESENT 3875 02:38:25,562 --> 02:38:26,797 IN HEALTHY TISSUE, TISSUE NOT 3876 02:38:26,864 --> 02:38:28,899 HAVING CANCER. 3877 02:38:28,966 --> 02:38:34,137 SO IN CANCER WE WE HAVE THIS 3878 02:38:34,204 --> 02:38:35,472 CANCER CHANGING CELL AND 3879 02:38:35,539 --> 02:38:36,340 WHATEVER TUMOR CELL MUTATION 3880 02:38:36,406 --> 02:38:39,843 THAT TUMOR CELL HAS IS BEING 3881 02:38:39,910 --> 02:38:41,378 AMPLIFIED IN ALL THESE DAUGHTER 3882 02:38:41,445 --> 02:38:45,849 CELLS, WE HAVE AMPLIFICATION OF 3883 02:38:45,916 --> 02:38:47,150 MUTATIONAL SIGNAL. 3884 02:38:47,217 --> 02:38:49,920 RIGHT NOW MOSTLY FOCUSED ON 3885 02:38:49,987 --> 02:38:51,455 CANCER OR GERMLINE MUTATION, CAN 3886 02:38:51,521 --> 02:38:53,523 ALSO APPRECIATE THERE IS SOME 3887 02:38:53,590 --> 02:38:55,926 MUTATIONAL SIGNATURES THAT CAN 3888 02:38:55,993 --> 02:38:57,895 BE INFERRED SOMETHING MUTATION 3889 02:38:57,961 --> 02:39:01,064 IN THE POPULATION THE GERMLINE. 3890 02:39:01,131 --> 02:39:03,166 TO LOOK AT OTHER, TO THE OTHER 3891 02:39:03,233 --> 02:39:07,404 RARE DISEASE, WE WILL HAVE TO GO 3892 02:39:07,471 --> 02:39:08,805 AND START TO INCREASE THE 3893 02:39:08,872 --> 02:39:11,708 SEQUENCING THAT IS BASED ON 3894 02:39:11,775 --> 02:39:13,443 SINGLE CELL WHERE WE CAN CALL 3895 02:39:13,510 --> 02:39:18,248 LOCATION AT SINGLE CELL LEVEL, 3896 02:39:18,315 --> 02:39:19,783 THERE'S NO SYNCHRONIZATION 3897 02:39:19,850 --> 02:39:22,986 BETWEEN MUTATION AT THE CELL 3898 02:39:23,053 --> 02:39:25,422 LEVEL UNLESS THERE'S A CANCER OF 3899 02:39:25,489 --> 02:39:28,125 GERMLINE, I HOPE THIS IS GOING 3900 02:39:28,191 --> 02:39:29,993 TO HAPPEN, AND WE WILL 3901 02:39:30,060 --> 02:39:32,262 UNDERSTAND, YOU KNOW, AT LEAST 3902 02:39:32,329 --> 02:39:38,802 SOME OF THE MOSAIC DISEASES OR, 3903 02:39:38,869 --> 02:39:40,604 YOU KNOW, RELATED TO THE 3904 02:39:40,671 --> 02:39:45,042 MUTATIONS THAT ARE SOMATIC 3905 02:39:45,108 --> 02:39:48,378 MUTATIONS, BUT ARE IN VARIOUS 3906 02:39:48,445 --> 02:39:50,981 (INDISCERNIBLE) NOT GERMLINE 3907 02:39:51,048 --> 02:39:53,717 MUTATION.. 3908 02:39:53,784 --> 02:39:55,585 GERMLINE MUTATION WE CAN STUDY 3909 02:39:55,652 --> 02:39:55,786 NOW. 3910 02:39:55,852 --> 02:39:59,656 >> I HAVE MORE OF A PROCESS 3911 02:39:59,723 --> 02:40:00,090 QUESTION FOR YOU. 3912 02:40:00,157 --> 02:40:03,260 WHAT HAS BEEN THE BIGGEST 3913 02:40:03,327 --> 02:40:04,227 CHALLENGES YOU'VE ENCOUNTERED AS 3914 02:40:04,294 --> 02:40:05,729 YOU'VE PURSUED THIS WORK AND HOW 3915 02:40:05,796 --> 02:40:07,297 MIGHT NLM CONTINUE TO HELP 3916 02:40:07,364 --> 02:40:08,632 REDUCE SOME OF THAT FRICTION FOR 3917 02:40:08,699 --> 02:40:12,235 THE TYPE OF RESEARCH THAT YOU'RE 3918 02:40:12,302 --> 02:40:12,803 ENGAGED IN? 3919 02:40:12,869 --> 02:40:17,708 >> SO, WE ARE MOSTLY 3920 02:40:17,774 --> 02:40:21,812 COMPUTATIONAL BIOLOGY GROUP, OUR 3921 02:40:21,878 --> 02:40:26,550 RESEARCH IS DRIVEN OF COURSE IN 3922 02:40:26,616 --> 02:40:28,652 MOSTLY IMPORTANT QUESTIONS BUT 3923 02:40:28,719 --> 02:40:32,022 ALSO BY AVAILABLE DATA. 3924 02:40:32,089 --> 02:40:36,426 SO, SOME OF IT IS COLLABORATION 3925 02:40:36,493 --> 02:40:39,262 WITH OUR EXPERIMENTAL COLLEAGUES 3926 02:40:39,329 --> 02:40:43,333 THAT HAVE SPECIFIC DATA AND 3927 02:40:43,400 --> 02:40:44,601 WOULD LIKE COLLABORATION TO 3928 02:40:44,668 --> 02:40:46,837 UNDERSTAND, BUT A LOT IS BASED 3929 02:40:46,903 --> 02:40:50,240 ON THE PUBLIC DATA. 3930 02:40:50,307 --> 02:40:54,611 SO, I THINK THAT REALLY IT'S 3931 02:40:54,678 --> 02:40:56,480 IMPORTANT FOR US TO, YOU KNOW, 3932 02:40:56,546 --> 02:40:59,116 HAVING ACCESS TO LARGE SET OF 3933 02:40:59,182 --> 02:41:04,688 UNBIASED DATA, THE DATA IS THAT, 3934 02:41:04,755 --> 02:41:06,556 YOU KNOW, OF QUESTION, DATA 3935 02:41:06,623 --> 02:41:08,859 MIGHT BE BIASED IN DIFFERENT 3936 02:41:08,925 --> 02:41:10,394 WAY, BIAS TO UNDERSTAND THOSE 3937 02:41:10,460 --> 02:41:11,461 BIASES, SO IT'S IMPORTANT TO 3938 02:41:11,528 --> 02:41:14,498 HAVE A LOT OF DATA, HAVE A LOT 3939 02:41:14,564 --> 02:41:19,369 OF DATA FROM THE SAME INDIVIDUAL 3940 02:41:19,436 --> 02:41:20,670 PREFERABLY, IT'S IMPORTANT IN 3941 02:41:20,737 --> 02:41:23,073 STUDY DESIGN TO BE FORWARD 3942 02:41:23,140 --> 02:41:24,841 THINKING AND THINK, YEAH, WE MAY 3943 02:41:24,908 --> 02:41:26,009 BE INTERESTED IN MUTATION BUT IN 3944 02:41:26,076 --> 02:41:27,811 FUTURE WE MAY WANT TO HAVE GENE 3945 02:41:27,878 --> 02:41:30,013 EXPRESSION, MAY WANT TO HAVE 3946 02:41:30,080 --> 02:41:32,949 METHYLATION, MAY WANT TO HAVE SO 3947 02:41:33,016 --> 02:41:33,717 MANY OTHER INFORMATION THAT 3948 02:41:33,784 --> 02:41:35,819 WOULD BE IMPORTANT SO THE MORE 3949 02:41:35,886 --> 02:41:38,889 INFORMATION WE HAVE ABOUT 3950 02:41:38,955 --> 02:41:41,391 INDIVIDUAL PATIENTS, THIS IS THE 3951 02:41:41,458 --> 02:41:43,894 MOST USEFUL FOR US, BECAUSE IT'S 3952 02:41:43,960 --> 02:41:45,462 EASIER TO LINK DIFFERENT TYPE OF 3953 02:41:45,529 --> 02:41:47,097 DATA TOGETHER IF THEY ARE BEING 3954 02:41:47,164 --> 02:41:49,399 COLLECTED FROM THE SAME 3955 02:41:49,466 --> 02:41:50,267 INDIVIDUALS. 3956 02:41:50,333 --> 02:41:53,670 I THINK THIS IS LIKE 3957 02:41:53,737 --> 02:41:56,273 AVAILABILITY OF DATA, QUALITY OF 3958 02:41:56,339 --> 02:41:58,909 DATA, EXTENT OF DATA AS 3959 02:41:58,975 --> 02:42:01,878 DICTATING WHAT WE CAN DO AND 3960 02:42:01,945 --> 02:42:04,147 NOT. 3961 02:42:04,214 --> 02:42:05,482 >> THANK YOU FOR THAT. 3962 02:42:05,549 --> 02:42:08,285 OTHER QUESTIONS? 3963 02:42:18,929 --> 02:42:19,062 OKAY. 3964 02:42:19,129 --> 02:42:21,131 >> I'LL TAKE IT FROM HERE. 3965 02:42:21,198 --> 02:42:22,899 I WANT TO THANK YOU FOR SHARING 3966 02:42:22,966 --> 02:42:24,301 YOUR WORK AND WORK OF YOUR 3967 02:42:24,367 --> 02:42:24,501 GROUP. 3968 02:42:24,568 --> 02:42:28,905 THIS IS A REALLY GREAT 3969 02:42:28,972 --> 02:42:30,173 CONVERSATION, AND IT'S EXCITING 3970 02:42:30,240 --> 02:42:31,675 TO SEE WHAT'S POSSIBLE HERE. 3971 02:42:31,741 --> 02:42:42,285 I WANT TO THANK DOCTORS OGUNYMI 3972 02:42:51,094 --> 02:42:55,398 AND SMIDER. 3973 02:42:55,465 --> 02:42:56,633 >> THANK YOU FOR THE ATTENTION 3974 02:42:56,700 --> 02:43:07,978 AND WONDERFUL QUESTIONS. 3975 02:43:08,044 --> 02:43:10,881 IT'S A PLEASURE TO HAVE DR. 3976 02:43:10,947 --> 02:43:12,182 GEORGE MENSAH, DIRECTOR OF 3977 02:43:12,249 --> 02:43:14,951 CENTER FOR TRANSLATION RESEARCH 3978 02:43:15,018 --> 02:43:19,789 AND IMPLEMENTATION SCIENCE, AT 3979 02:43:19,856 --> 02:43:25,729 THE NATIONAL HEART, LUNG AND 3980 02:43:25,795 --> 02:43:29,499 BLOOD INSTITUTE, PROVIDES 3981 02:43:29,566 --> 02:43:32,302 STRATEGIC OVERSIGHT FOR THE 3982 02:43:32,369 --> 02:43:34,171 PROGRAMS AND MANAGES LATE STAGE 3983 02:43:34,237 --> 02:43:35,138 TRANSLATION RESEARCH AN 3984 02:43:35,205 --> 02:43:36,673 IMPLEMENTATION SCIENCE EFFORTS. 3985 02:43:36,740 --> 02:43:39,543 AS WELL AS ITS DIVERSE RESEARCH 3986 02:43:39,609 --> 02:43:40,744 PORTFOLIO. 3987 02:43:40,810 --> 02:43:44,247 HIS AREAS OF EXPERTISE ARE IN 3988 02:43:44,314 --> 02:43:46,850 CARDIOVASCULAR MEDICINE, PUBLIC 3989 02:43:46,917 --> 02:43:49,286 HEALTH, SCIENCE, COMMUNITY 3990 02:43:49,352 --> 02:43:50,587 ENGAGED RESEARCH, HEALTH 3991 02:43:50,654 --> 02:43:51,922 DISPARITIES RESEARCH, GLOBAL 3992 02:43:51,988 --> 02:43:53,857 HEALTH RESEARCH. 3993 02:43:53,924 --> 02:43:56,693 DR. MENSAH IS A CLINICAL 3994 02:43:56,760 --> 02:44:01,198 SCIENTIST, TRAINED IN INTERNAL 3995 02:44:01,264 --> 02:44:02,632 MEDICINE, SUBSPECIALTY OF 3996 02:44:02,699 --> 02:44:03,133 CARDIOVASCULAR DISEASE, 3997 02:44:03,200 --> 02:44:03,800 PROFESSIONAL EXPERIENCE INCLUDES 3998 02:44:03,867 --> 02:44:06,102 25 YEARS OF PUBLIC SERVICE 3999 02:44:06,169 --> 02:44:08,838 BETWEEN THE V.A., CDC, NIH. 4000 02:44:08,905 --> 02:44:12,008 HE IS HERE TODAY TO PRESENT ON 4001 02:44:12,075 --> 02:44:16,713 THE NIH COMMUNITY ENGAGEMENT 4002 02:44:16,780 --> 02:44:20,450 ALLIANCE, CEAL PROGRAM. 4003 02:44:20,517 --> 02:44:24,888 WELCOME, DISC, ALREADY MENSA. 4004 02:44:24,955 --> 02:44:25,855 >> THANK YOU, KRISTI. 4005 02:44:25,922 --> 02:44:29,226 I'M GOING TO SHARE MY DESKTOP. 4006 02:44:29,292 --> 02:44:30,794 LET ME KNOW IF YOU SEE MY 4007 02:44:30,860 --> 02:44:31,127 SCREEN. 4008 02:44:31,194 --> 02:44:35,365 >> I DO. 4009 02:44:35,432 --> 02:44:36,466 EVERYTHING LOOKS GREAT. 4010 02:44:36,533 --> 02:44:37,801 >> THANKS FOR INVITING ME TO 4011 02:44:37,867 --> 02:44:42,272 SPEAK WITH YOU THIS AFTERNOON. 4012 02:44:42,339 --> 02:44:44,140 I'M VERY GRATEFUL FOR -- IT'S 4013 02:44:44,207 --> 02:44:46,543 TRULY A PRIVILEGE FOR ME AND A 4014 02:44:46,610 --> 02:44:47,410 PERSONAL PLEASURE TO HAVE THE 4015 02:44:47,477 --> 02:44:49,713 OPPORTUNITY TO BE WITH YOU 4016 02:44:49,779 --> 02:44:50,347 TODAY. 4017 02:44:50,413 --> 02:45:00,223 I WANT TO RECOGNIZE MY 4018 02:45:00,290 --> 02:45:01,658 COLLEAGUE, DR. PALTOOL WHO 4019 02:45:01,725 --> 02:45:02,959 ENCOURAGE IMMEDIATE TO ACCEPT 4020 02:45:03,026 --> 02:45:06,229 BUT ACCEPTING WAS EASY. 4021 02:45:06,296 --> 02:45:13,570 I DON'T KNOW OF WHO WOULD TURN 4022 02:45:13,637 --> 02:45:15,305 DOWN THE OPPORTUNITY TO SPEAK 4023 02:45:15,372 --> 02:45:19,709 FOR THE BOARD OF REGENTS FOR 4024 02:45:19,776 --> 02:45:22,679 THE NLM, A NATIONAL TREASURE. 4025 02:45:22,746 --> 02:45:26,283 PERSONALLY I'VE BENEFITED 4026 02:45:26,349 --> 02:45:27,050 TREMENDOUSLY FROM THE NATIONAL 4027 02:45:27,117 --> 02:45:28,785 LIBRARY OF MEDICINE. 4028 02:45:28,852 --> 02:45:31,288 NLM IS A REAL TREASURE THAT'S 4029 02:45:31,354 --> 02:45:36,226 BEEN SERVING SCIENCE AND SOCIETY 4030 02:45:36,293 --> 02:45:37,294 SINCE 1836, AND EVEN BACK WHEN 4031 02:45:37,360 --> 02:45:39,596 IT WAS ONLY A COLLECTION OF 4032 02:45:39,663 --> 02:45:41,598 BOOKS AND JOURNALS TO DELIVER 4033 02:45:41,665 --> 02:45:44,134 REMARKABLE 21ST CENTURY CURES 4034 02:45:44,200 --> 02:45:48,171 LIBRARY OF TODAY, IT'S BEEN A 4035 02:45:48,238 --> 02:45:48,938 TRUE GEM. 4036 02:45:49,005 --> 02:45:53,176 I LIKE THIS IMAGE HERE, IT 4037 02:45:53,243 --> 02:45:54,544 REMINDS ME ALMOST 40 YEARS AGO 4038 02:45:54,611 --> 02:45:58,415 WHEN I WAS A MEDICAL INTERN, 4039 02:45:58,481 --> 02:45:59,282 EVERY WEEK, ESPECIALLY WEEKENDS, 4040 02:45:59,349 --> 02:46:02,018 I WOULD GO TO A SPECIAL ROOM AT 4041 02:46:02,085 --> 02:46:04,754 CORNELL, WHERE WE HAD A WORK 4042 02:46:04,821 --> 02:46:07,157 STATION, YOU WOULD LOAD A CDROM 4043 02:46:07,223 --> 02:46:11,528 AND GET TO ACCESS ALL THE MOST 4044 02:46:11,594 --> 02:46:13,496 RECENTLY PUBLISHED MEDICAL 4045 02:46:13,563 --> 02:46:13,797 LITERATURE. 4046 02:46:13,863 --> 02:46:16,566 THE FIRST THREE SCIENTIFIC 4047 02:46:16,633 --> 02:46:17,867 PAPERS I PUBLISHED COULD NOT 4048 02:46:17,934 --> 02:46:18,868 HAVE BEEN DOWN WITHOUT THE 4049 02:46:18,935 --> 02:46:21,237 SUPPORT OF DATA ACCESS TO 4050 02:46:21,304 --> 02:46:23,039 NATIONAL LIBRARY OF MEDICINE. 4051 02:46:23,106 --> 02:46:25,375 EVEN TODAY, I CAN SAY HONESTLY 4052 02:46:25,442 --> 02:46:27,210 THAT NOT A DAY GOES BY WHEN I 4053 02:46:27,277 --> 02:46:28,945 DON'T GO TO PubMed, AT LEAST 4054 02:46:29,012 --> 02:46:30,480 ONCE OR TWICE A DAY. 4055 02:46:30,547 --> 02:46:32,549 SO THANK YOU. 4056 02:46:32,615 --> 02:46:36,152 IT'S REALLY REMARKABLE THAT THE 4057 02:46:36,219 --> 02:46:38,455 TRUST THAT YOU BUILT WITHIN OUR 4058 02:46:38,521 --> 02:46:42,192 PROFESSION IN TERMS OF WHAT YOU 4059 02:46:42,258 --> 02:46:44,894 SHARE AND PROGRAMS YOU HAVE 4060 02:46:44,961 --> 02:46:45,895 REALLY DESERVE PRAISE. 4061 02:46:45,962 --> 02:46:49,399 SO AS I THOUGHT ABOUT ALL OF 4062 02:46:49,466 --> 02:46:50,934 THIS, IN PUTTING MY PRESENTATION 4063 02:46:51,000 --> 02:46:53,136 TOGETHER, I THOUGHT OF THE 4064 02:46:53,203 --> 02:46:56,306 CENTRAL QUESTION THAT I HOPE WE 4065 02:46:56,373 --> 02:46:57,407 CAN CONTEMPLATE THROUGHOUT THE 4066 02:46:57,474 --> 02:47:00,910 LECTURE AND WOULD LOVE TO HEAR 4067 02:47:00,977 --> 02:47:02,112 YOUR THOUGHTS, YOUR GUIDANCE, 4068 02:47:02,178 --> 02:47:03,313 HOW TO MOVE FORWARD. 4069 02:47:03,380 --> 02:47:05,382 THE QUESTION IS THIS. 4070 02:47:05,448 --> 02:47:09,419 HOW DO WE MAKE SURE THAT AS WE 4071 02:47:09,486 --> 02:47:14,457 DEVELOP THE INNOVATION, THE 4072 02:47:14,524 --> 02:47:15,058 REMARKABLE TECHNOLOGY, THE 4073 02:47:15,125 --> 02:47:17,193 COMPUTATIONAL CAPABILITIES OF 4074 02:47:17,260 --> 02:47:19,929 21ST CENTURY CURES LIBRARY HOW 4075 02:47:19,996 --> 02:47:25,502 DO WE MOVE TO NEEDS OF 4076 02:47:25,568 --> 02:47:27,604 COMMUNITIES TRADITIONALLY 4077 02:47:27,670 --> 02:47:29,672 UNDERSERVED, AND 4078 02:47:29,739 --> 02:47:31,207 DISPROPORTIONATELY IMPACTED BY 4079 02:47:31,274 --> 02:47:33,276 DISEASES AND RISKS THAT WE 4080 02:47:33,343 --> 02:47:34,177 PERFORM RESEARCH ON. 4081 02:47:34,244 --> 02:47:36,312 THAT IS THE CENTRAL QUESTION 4082 02:47:36,379 --> 02:47:37,881 THAT RUNS THROUGH WHAT I WILL 4083 02:47:37,947 --> 02:47:40,216 SHARE WITH YOU THIS AFTERNOON. 4084 02:47:40,283 --> 02:47:42,619 AND I WOULD BEGIN WITH GIVING 4085 02:47:42,685 --> 02:47:45,455 YOU A LITTLE BIT OF HISTORY OF 4086 02:47:45,522 --> 02:47:47,657 NIH COMMUNITY ENGAGEMENT 4087 02:47:47,724 --> 02:47:49,092 ALLIANCE WE CALL CEAL. 4088 02:47:49,159 --> 02:47:54,330 AND SHARE WHERE WE ARE TODAY IN 4089 02:47:54,397 --> 02:47:59,869 TERMS OF PROGRAMMING AND WHAT 4090 02:47:59,936 --> 02:48:00,904 THE FUTURE LOOKS LIKE, AND THIS 4091 02:48:00,970 --> 02:48:03,306 AUDIENCE IS VERY MUCH AWARE OF 4092 02:48:03,373 --> 02:48:10,180 THE CRUCIAL ROLE DATA DIENS AND 4093 02:48:10,246 --> 02:48:12,482 OF -- DATA SCIENCE AND 4094 02:48:12,549 --> 02:48:13,383 INFORMATICS PLAY. 4095 02:48:13,450 --> 02:48:15,018 I WOULD LIKE TO MAKE A STRONG 4096 02:48:15,084 --> 02:48:17,854 CASE FOR ENSURING THE 4097 02:48:17,921 --> 02:48:20,290 CAPABILITIES WE BUILD IN THESE 4098 02:48:20,356 --> 02:48:21,157 AREAS CAN REALLY HELP 4099 02:48:21,224 --> 02:48:23,226 COMMUNITIES TO THRIVE. 4100 02:48:23,293 --> 02:48:26,396 THAT'S WHAT I SEE FROM POTENTIAL 4101 02:48:26,463 --> 02:48:28,631 STRATEGIC ALLIANCE OF CEAL AND 4102 02:48:28,698 --> 02:48:29,899 NATIONAL LIBRARY OF MEDICINE. 4103 02:48:29,966 --> 02:48:33,069 SO, TO BEGIN WITH A LITTLE BIT 4104 02:48:33,136 --> 02:48:37,273 OF HISTORY, IT WAS ON A SATURDAY 4105 02:48:37,340 --> 02:48:39,108 AFTERNOON, JULY 4, 2020, WHEN 4106 02:48:39,175 --> 02:48:41,744 DR. FRANCIS COLLINS, OUR FORMER 4107 02:48:41,811 --> 02:48:44,380 NIH DIRECTOR, CONVENED HIS 4108 02:48:44,447 --> 02:48:46,649 LEADERSHIP GROUP TO EXPLORE 4109 02:48:46,716 --> 02:48:51,588 ADDITIONAL STEPS TO MAKE SURE 4110 02:48:51,654 --> 02:48:53,890 THAT ADVANCES WERE MAKING AND 4111 02:48:53,957 --> 02:48:56,426 RESPONSES TO COVID-19 WERE 4112 02:48:56,493 --> 02:48:57,727 APPROPRIATELY INCLUSIVE AND 4113 02:48:57,794 --> 02:48:58,161 DIVERSE. 4114 02:48:58,228 --> 02:49:00,497 NOW, IT WAS A NATIONAL HOLIDAY. 4115 02:49:00,563 --> 02:49:01,564 IT WAS A SATURDAY. 4116 02:49:01,631 --> 02:49:03,533 AND YET HE CALLED A MEETING 4117 02:49:03,600 --> 02:49:06,402 BECAUSE WE HAD A SERIOUS PROBLEM 4118 02:49:06,469 --> 02:49:07,370 ON OUR HANDS. 4119 02:49:07,437 --> 02:49:13,710 WE HAD DEVELOPED A REMARKABLE 4120 02:49:13,776 --> 02:49:15,378 VACCINE, 90% EFFICACY, AND 4121 02:49:15,445 --> 02:49:17,213 PEOPLE WHO NEEDED VACCINE THE 4122 02:49:17,280 --> 02:49:18,882 MOST WERE VERY UNWILLING TO 4123 02:49:18,948 --> 02:49:21,284 PARTICIPATE IN THE CLINICAL 4124 02:49:21,351 --> 02:49:23,786 TRIAL TO PROVE ITS 4125 02:49:23,853 --> 02:49:24,153 EFFECTIVENESS. 4126 02:49:24,220 --> 02:49:25,355 DR. COLLINS IDENTIFIED TWO OF 4127 02:49:25,421 --> 02:49:28,625 OUR I.C. INSTITUTE AND CENTER 4128 02:49:28,691 --> 02:49:30,627 DIRECTORS, DR. GARY GIBBONS, 4129 02:49:30,693 --> 02:49:31,461 DIRECTOR FOR NATIONAL HEART, 4130 02:49:31,528 --> 02:49:35,865 LUNG AND BLOOD INSTITUTE, AND 4131 02:49:35,932 --> 02:49:36,633 DR. ELISEO STABLE-PEREZ, 4132 02:49:36,699 --> 02:49:38,134 DIRECTOR OF THE NATIONAL 4133 02:49:38,201 --> 02:49:42,105 INSTITUTE OF MENTAL HEALTH AND 4134 02:49:42,171 --> 02:49:43,439 HEALTH DISPARITIES, CO-CHAIRS. 4135 02:49:43,506 --> 02:49:46,075 WITHIN A WEEK OF THAT MEETING WE 4136 02:49:46,142 --> 02:49:48,711 CONVENED THE FIRST COMMUNITY 4137 02:49:48,778 --> 02:49:50,013 ENGAGED ROUNDTABLE SO WE COULD 4138 02:49:50,079 --> 02:49:52,048 LISTEN TO THE COMMUNITIES AND 4139 02:49:52,115 --> 02:49:53,850 HEAR MANY OF THE CHALLENGES THAT 4140 02:49:53,917 --> 02:49:57,253 WE FACE AND WHY MANY OF THEM 4141 02:49:57,320 --> 02:49:58,321 DIDN'T WANT TO PARTICIPATE IN 4142 02:49:58,388 --> 02:50:01,824 THE CLINICAL TRIAL INVOLVING A 4143 02:50:01,891 --> 02:50:04,460 LIFE-SAVING VACCINE. 4144 02:50:04,527 --> 02:50:08,865 HE FOLLOWED UP WITH ANOTHER 4145 02:50:08,932 --> 02:50:09,799 LISTENING SESSION, AND JULY 22 4146 02:50:09,866 --> 02:50:15,104 WENT BACK TO DR. DR. COLLINS 4147 02:50:15,171 --> 02:50:16,139 TO SHARE WHAT WE LEARNED. 4148 02:50:16,205 --> 02:50:17,974 THOSE WERE NOT THE ONLY TWO 4149 02:50:18,041 --> 02:50:19,042 LISTENING SESSIONS WE HAD. 4150 02:50:19,108 --> 02:50:24,380 AS I SHOW YOU IN THIS FIGURE, 4151 02:50:24,447 --> 02:50:25,615 THE RED TRIANGLES SHOW 4152 02:50:25,682 --> 02:50:28,051 INDIVIDUAL TIMES WHEN WE WENT 4153 02:50:28,117 --> 02:50:30,153 BACK AND HELD A FORUM SO WE 4154 02:50:30,219 --> 02:50:32,388 COULD MAKE SURE WE WERE DOING 4155 02:50:32,455 --> 02:50:35,458 WHAT WE HEARD AND CONTINUED TO 4156 02:50:35,525 --> 02:50:38,661 LISTEN TO GUIDE, CRUCIAL 4157 02:50:38,728 --> 02:50:39,729 COMPONENTS OF OUR WORK. 4158 02:50:39,796 --> 02:50:42,465 THIS SLIDE SHARES A SUMMARY OF 4159 02:50:42,532 --> 02:50:46,102 SOME KEY MESSAGES WE HEARD. 4160 02:50:46,169 --> 02:50:48,738 TRUST IS EXTREMELY IMPORTANT AND 4161 02:50:48,805 --> 02:50:50,006 FOUNDATIONAL IN COMMUNITY 4162 02:50:50,073 --> 02:50:50,306 ENGAGEMENT. 4163 02:50:50,373 --> 02:50:51,874 WE ALSO LEARNED THAT COMMUNITY 4164 02:50:51,941 --> 02:50:56,579 ENGAGEMENT IS NOT JUST OUTREACH, 4165 02:50:56,646 --> 02:50:57,680 NOT NIH COMING TO TELL 4166 02:50:57,747 --> 02:50:59,115 COMMUNITIES WHAT THEY NEEDED TO 4167 02:50:59,182 --> 02:51:00,617 DO BUT NIH COMING AND LISTENING 4168 02:51:00,683 --> 02:51:05,321 AND WORKING WITH THE COMMUNITIES 4169 02:51:05,388 --> 02:51:06,889 AND CO-CREATING STRATEGIES THAT 4170 02:51:06,956 --> 02:51:08,725 WOULD PROMOTE THEIR HEALTH. 4171 02:51:08,791 --> 02:51:11,527 WE ALSO HEARD THAT WE NEEDED TO 4172 02:51:11,594 --> 02:51:13,529 MEET COMMUNITIES WHERE THEY ARE, 4173 02:51:13,596 --> 02:51:16,599 ALL COMMUNITIES ARE DIFFERENT 4174 02:51:16,666 --> 02:51:17,700 LEVELS OF ORGANIZATIONAL 4175 02:51:17,767 --> 02:51:19,569 READINESS FOR CHANGE, WITHOUT 4176 02:51:19,636 --> 02:51:22,171 TAKING THAT ACCOUNT WE'RE NOT 4177 02:51:22,238 --> 02:51:24,607 LIKELY TO BE AS HELPFUL AS WE 4178 02:51:24,674 --> 02:51:25,341 COULD BE. 4179 02:51:25,408 --> 02:51:35,184 SOCIAL AND STRUCTURAL DETERMINE 4180 02:51:35,251 --> 02:51:36,386 DETERMINANTS WERE IMPORTANT AND 4181 02:51:36,452 --> 02:51:37,487 WHEN WE'RE DESIGNING A CLINICAL 4182 02:51:37,553 --> 02:51:39,555 TRIAL, WHEN WE HAVE THE RESULTS, 4183 02:51:39,622 --> 02:51:49,332 AND MAKING SURE THAT THEY 4184 02:51:49,399 --> 02:51:50,433 BENEFITED FROM RESEARCH RESULT. 4185 02:51:50,500 --> 02:51:53,269 THE LAST TWO ARE RELEVANT TO 4186 02:51:53,336 --> 02:51:57,473 THIS DISCUSSION BECAUSE THE 4187 02:51:57,540 --> 02:51:59,442 OPPORTUNITY TO SPREAD 4188 02:51:59,509 --> 02:52:00,843 TRUSTWORTHY INFORMATION AND 4189 02:52:00,910 --> 02:52:03,579 OPPORTUNITY FACILITATE ACCESS TO 4190 02:52:03,646 --> 02:52:05,014 HEALTH DATA SO THESE COMMUNITIES 4191 02:52:05,081 --> 02:52:06,149 WOULD THRIVE, THAT'S SOMETHING 4192 02:52:06,215 --> 02:52:08,484 THAT NLM CAN PLAY A CRUCIAL ROLE 4193 02:52:08,551 --> 02:52:08,818 IN. 4194 02:52:08,885 --> 02:52:11,454 SO HERE IS OUR CHARGE. 4195 02:52:11,521 --> 02:52:12,889 WE'RE NIH. 4196 02:52:12,955 --> 02:52:14,123 SO WE CONDUCT RESEARCH, AT THIS 4197 02:52:14,190 --> 02:52:18,761 TIME IT WAS URGENT RESEARCH, NOT 4198 02:52:18,828 --> 02:52:20,897 WAITING FIVE YEARS TO SEE THE 4199 02:52:20,963 --> 02:52:23,933 OUTCOME, ALMOST IMMEDIATELY 4200 02:52:24,000 --> 02:52:25,268 NEEDED TO KNOW WHAT TO DO TO 4201 02:52:25,334 --> 02:52:28,237 PROTECT THE MOST LIVES AND 4202 02:52:28,304 --> 02:52:31,240 WANTED TO PROMOTE AND FACILITATE 4203 02:52:31,307 --> 02:52:32,909 INCLUSION OF DIVERSE RACIAL AND 4204 02:52:32,975 --> 02:52:35,978 ETHNIC POPULATIONS IN OUR 4205 02:52:36,045 --> 02:52:41,884 CLINICAL TRIAL, AND PARTICULARLY 4206 02:52:41,951 --> 02:52:42,752 REFLECTIVE OF POPULATIONS 4207 02:52:42,819 --> 02:52:43,386 DISPROPORTIONATELY AFFECTED BY 4208 02:52:43,453 --> 02:52:43,986 THE PANDEMIC. 4209 02:52:44,053 --> 02:52:47,824 THIS IS OUR MANTRA. 4210 02:52:47,890 --> 02:52:50,226 NO MATTER HOW URGENT, WE WERE 4211 02:52:50,293 --> 02:52:53,629 TOLD WE ALWAYS NEEDED TO MOVE AT 4212 02:52:53,696 --> 02:52:55,131 THE SPEED OF TRUST. 4213 02:52:55,198 --> 02:52:58,067 WE DID A FEW THINGS INITIALLY. 4214 02:52:58,134 --> 02:52:59,836 WE WANTED TO MAKE SURE THAT 4215 02:52:59,902 --> 02:53:01,370 PEOPLE ARE GOING INTO 4216 02:53:01,437 --> 02:53:02,472 COMMUNITIES, RECOGNIZING WE 4217 02:53:02,538 --> 02:53:04,207 COULDN'T BOIL THE OCEAN, WE 4218 02:53:04,273 --> 02:53:07,043 NEEDED TO SELECT THE COMMUNITIES 4219 02:53:07,110 --> 02:53:09,579 THAT HAVE GREATEST RISK, HIGHEST 4220 02:53:09,645 --> 02:53:11,848 RISING CONFIRMED CASES OF COVID, 4221 02:53:11,914 --> 02:53:16,452 WE ALSO WANTED TO MAKE SURE WE 4222 02:53:16,519 --> 02:53:18,654 WERE IN COMMUNITIES THAT WERE 4223 02:53:18,721 --> 02:53:21,591 HOUSED OR NEAR NIH-FUNDED 4224 02:53:21,657 --> 02:53:22,792 CENTERS AND INSTITUTIONS, WHERE 4225 02:53:22,859 --> 02:53:23,559 THERE WERE CLINICAL TRIALS, 4226 02:53:23,626 --> 02:53:25,428 WHERE WE COULD REFER THEM TO, 4227 02:53:25,495 --> 02:53:28,631 AND OTHER NIH ASSETS THAT COULD 4228 02:53:28,698 --> 02:53:30,466 BE LEVERAGED. 4229 02:53:30,533 --> 02:53:35,505 BUT WE REALLY PLACED OUR 4230 02:53:35,571 --> 02:53:36,472 REGIONAL CENTERS PARTICULARLY 4231 02:53:36,539 --> 02:53:37,507 GEOGRAPHIC LOCATIONS SO WE COULD 4232 02:53:37,573 --> 02:53:40,009 COVER MOST OF THE U.S. AND IN 4233 02:53:40,076 --> 02:53:42,545 PARTICULAR COVER THE AREAS THAT 4234 02:53:42,612 --> 02:53:44,046 HAD THE HIGHEST RISK, AND 4235 02:53:44,113 --> 02:53:46,149 CERTAINLY WANTED TO MAKE SURE 4236 02:53:46,215 --> 02:53:49,652 THAT WE ARE ADDRESSING ALL AGES 4237 02:53:49,719 --> 02:53:51,053 ACROSS THE LIFESPAN, BOTH MEN 4238 02:53:51,120 --> 02:53:54,323 AND WOMEN, AS WELL AS RACE, 4239 02:53:54,390 --> 02:53:56,526 ETHNICITY, TAKING RURAL 4240 02:53:56,592 --> 02:53:57,827 LOCATIONS ALSO INTO ACCOUNT. 4241 02:53:57,894 --> 02:54:01,564 THIS IS A NICE SYNOPSIS OF SOME 4242 02:54:01,631 --> 02:54:03,766 OF OUR KEY OBJECTIVES, WHILE 4243 02:54:03,833 --> 02:54:04,867 SPONSORING AND SUPPORTING 4244 02:54:04,934 --> 02:54:08,070 RESEARCH, WE WANTED TO MAKE SURE 4245 02:54:08,137 --> 02:54:10,873 AN EQUALLY IMPORTANT ROLE WAS 4246 02:54:10,940 --> 02:54:12,742 BUILDING AND SUSTAINING TRUST AT 4247 02:54:12,809 --> 02:54:14,043 RELATIONSHIPS FOR THE COMMUNITY. 4248 02:54:14,110 --> 02:54:17,079 AND ENABLING THEM TO BE ABLE TO 4249 02:54:17,146 --> 02:54:19,215 BENEFIT AND SHARE IN THE 4250 02:54:19,282 --> 02:54:21,918 KNOWLEDGE THAT WAS RAPIDLY 4251 02:54:21,984 --> 02:54:23,352 EVOLVING, CERTAINLY BUILDING A 4252 02:54:23,419 --> 02:54:25,655 NETWORK THAT COULD BE SUSTAINED, 4253 02:54:25,721 --> 02:54:26,622 PROMOTING ACCESS TO THE EXPERTS 4254 02:54:26,689 --> 02:54:30,159 WE HAVE AT NIH AND OTHER FEDERAL 4255 02:54:30,226 --> 02:54:31,894 AGENCIES, BUT MOST IMPORTANTLY 4256 02:54:31,961 --> 02:54:34,831 MAKING SURE THAT WE PROMOTED 4257 02:54:34,897 --> 02:54:35,665 TRUSTWORTHY INFORMATION. 4258 02:54:35,731 --> 02:54:39,802 THESE ARE THE CORE PRINCIPLES, 4259 02:54:39,869 --> 02:54:41,270 SELF-EXPLANATORY, BUT REALLY, 4260 02:54:41,337 --> 02:54:43,105 REALLY IMPORTANT THAT WE BE 4261 02:54:43,172 --> 02:54:45,074 NIMBLE AND ABLE TO CHANGE, 4262 02:54:45,141 --> 02:54:48,811 ADAPT, BASED ON THE NEEDS AND 4263 02:54:48,878 --> 02:54:50,346 UNIQUE CHARACTERISTICS OF EVERY 4264 02:54:50,413 --> 02:54:51,514 COMMUNITY WE WORKED IN. 4265 02:54:51,581 --> 02:54:54,183 I HAVE TO GIVE CREDIT AGAIN TO 4266 02:54:54,250 --> 02:54:56,052 THE NATIONAL LIBRARY OF MEDICINE 4267 02:54:56,118 --> 02:54:57,787 BECAUSE IN THAT FIRST YEAR, 4268 02:54:57,854 --> 02:54:58,855 DURING THOSE CHALLENGING YEARS, 4269 02:54:58,921 --> 02:55:00,823 WE HAD A LOT OF HELP FROM A LOT 4270 02:55:00,890 --> 02:55:02,491 OF PLACES. 4271 02:55:02,558 --> 02:55:04,327 THE NLM WAS ONE. 4272 02:55:04,393 --> 02:55:06,429 EVEN ON SOCIAL MEDIA, NLM WAS 4273 02:55:06,495 --> 02:55:07,730 TWEETING ABOUT US. 4274 02:55:07,797 --> 02:55:08,931 WE REALLY APPRECIATED IT. 4275 02:55:08,998 --> 02:55:12,535 ONE WAY OF GETTING THE MESSAGE 4276 02:55:12,602 --> 02:55:12,735 OUT. 4277 02:55:12,802 --> 02:55:16,138 WE HAVE LISTSERVs THAT GO TO 4278 02:55:16,205 --> 02:55:17,006 CLINICIAN-SCIENTISTS, OTHER 4279 02:55:17,073 --> 02:55:18,674 SCIENTISTS, PEOPLE WE FUND, BUT 4280 02:55:18,741 --> 02:55:20,109 IT MAKES A BIG DIFFERENCE IF 4281 02:55:20,176 --> 02:55:21,644 WE'RE GOING TO REACH COMMUNITIES 4282 02:55:21,711 --> 02:55:25,181 WHERE THEY ARE THAT WE USE 4283 02:55:25,248 --> 02:55:26,015 MULTI-CHANNEL APPROACHES AND 4284 02:55:26,082 --> 02:55:29,518 SOCIAL MEDIA WAS ONE. 4285 02:55:29,585 --> 02:55:34,991 SO THESE ARE ALL FROM X, 4286 02:55:35,057 --> 02:55:36,058 FORMERLY KNOWN AS TWITTER. 4287 02:55:36,125 --> 02:55:37,827 WE APPRECIATE THE HELP FROM NLM. 4288 02:55:37,894 --> 02:55:40,563 THE FIRST YEAR MOSTLY DEALT WITH 4289 02:55:40,630 --> 02:55:41,097 COVID. 4290 02:55:41,163 --> 02:55:45,701 DEALT WITH VACCINE HESITANCY AND 4291 02:55:45,768 --> 02:55:46,636 MISINFORMATION ABOUT THE 4292 02:55:46,702 --> 02:55:48,237 RESEARCH THAT LED TO THE 4293 02:55:48,304 --> 02:55:49,872 VACCINE, AND WE THINK WE DID A 4294 02:55:49,939 --> 02:55:52,074 REASONABLE GOOD JOB. 4295 02:55:52,141 --> 02:55:53,576 WE MANAGED TO HIT THE TARGET 4296 02:55:53,643 --> 02:55:57,613 THAT WE HAD SET IN TERMS OF THE 4297 02:55:57,680 --> 02:55:59,181 ENROLLMENT IN CLINICAL TRIALS 4298 02:55:59,248 --> 02:56:00,917 BUT DID SOMETHING MORE. 4299 02:56:00,983 --> 02:56:03,119 ABLE WITH THE SUPPORT FROM ALL 4300 02:56:03,185 --> 02:56:06,188 THE I.C.s, INCLUDING NLM, WERE 4301 02:56:06,255 --> 02:56:10,493 ABLE TO BUILD AN INFRASTRUCTURE 4302 02:56:10,559 --> 02:56:12,428 THAT CAN SERVE AS PLATFORM FOR 4303 02:56:12,495 --> 02:56:13,963 FUTURE WORK WITH THE 4304 02:56:14,030 --> 02:56:15,364 COMMUNITIES. 4305 02:56:15,431 --> 02:56:16,365 AND THAT'S SOME EXAMPLES THAT I 4306 02:56:16,432 --> 02:56:18,334 WILL SHARE WITH YOU. 4307 02:56:18,401 --> 02:56:22,371 ALL THE WORK IN CEAL WAS REALLIY 4308 02:56:22,438 --> 02:56:23,572 TOWARD HEALTH EQUITY. 4309 02:56:23,639 --> 02:56:27,610 THE BACKBONE OF THE COMMUNITY 4310 02:56:27,677 --> 02:56:29,612 ENGAGEMENT ALLIANCE WAS THE 21 4311 02:56:29,679 --> 02:56:31,681 REGIONAL TEAMS THAT WE SUPPORTED 4312 02:56:31,747 --> 02:56:35,851 WITH THE CORE PURPOSE PROMOTING 4313 02:56:35,918 --> 02:56:36,919 COMMUNITY ENGAGED RESEARCH 4314 02:56:36,986 --> 02:56:39,021 THROUGH ACCESS IN DIVERSE 4315 02:56:39,088 --> 02:56:40,756 NETWORKS OF COMMUNITY, ACADEMIC, 4316 02:56:40,823 --> 02:56:42,291 AS WELL AS RESEARCH 4317 02:56:42,358 --> 02:56:42,625 PARTNERSHIPS. 4318 02:56:42,692 --> 02:56:47,763 WE HAD MORE THAN A THOUSAND 4319 02:56:47,830 --> 02:56:49,298 COMMUNITY PARTNERS, ABOUT 580 4320 02:56:49,365 --> 02:56:52,268 SMALL TO MEDIUM SIZED 4321 02:56:52,335 --> 02:56:53,336 COMMUNITY-BASED ORGANIZATION, 4322 02:56:53,402 --> 02:56:54,203 ACADEMIC HEALTH CENTERS, STRONG 4323 02:56:54,270 --> 02:56:57,306 TRACK RECORD OF COMMUNITY 4324 02:56:57,373 --> 02:56:59,575 ENGAGED RESEARCH, PARTICULARLY 4325 02:56:59,642 --> 02:57:00,876 WORKING WITH UNDERSERVED 4326 02:57:00,943 --> 02:57:04,714 COMMUNITIES AND CERTAINLY NOW 4327 02:57:04,780 --> 02:57:06,782 STRONG FOCUS ON INFORMATIONAL 4328 02:57:06,849 --> 02:57:07,550 RESEARCH, COMMUNITY 4329 02:57:07,616 --> 02:57:09,752 INTERVENTIONS WITH SOME BASIS IN 4330 02:57:09,819 --> 02:57:12,154 EVIDENCE RATHER THAN 4331 02:57:12,221 --> 02:57:14,023 OBSERVATIONAL WORK ALONE. 4332 02:57:14,090 --> 02:57:17,193 RECOGNIZING CRUCIAL IMPORTANCE 4333 02:57:17,259 --> 02:57:18,928 OF PRIMARY CARE, WE SUPPORTED 4334 02:57:18,995 --> 02:57:22,331 TWO TEAMS THAT HAD VERY BROAD 4335 02:57:22,398 --> 02:57:27,470 REACH, PARTICULARLY ACROSS 4336 02:57:27,536 --> 02:57:32,274 SOUTHEAST AND WESTERN U.S., 4337 02:57:32,341 --> 02:57:35,978 NETWORK OF COMMUNITY ENGAGED 4338 02:57:36,045 --> 02:57:37,613 RESEARCH, WITH SEVERAL 4339 02:57:37,680 --> 02:57:38,714 ACTIVITIES INCLUDING PATIENT 4340 02:57:38,781 --> 02:57:40,816 REGISTRY THAT'S GOING TO EVOLVE 4341 02:57:40,883 --> 02:57:43,919 AND INCREASE IN DEPTH. 4342 02:57:43,986 --> 02:57:46,956 BUT ALSO CLINICAL TRIALS THAT 4343 02:57:47,023 --> 02:57:48,524 IDENTIFY SOCIAL RISK OF THE 4344 02:57:48,591 --> 02:57:51,160 COMMUNITIES IN WHICH WE SERVE, 4345 02:57:51,227 --> 02:57:53,029 LINKED COMMUNITIES TO 4346 02:57:53,095 --> 02:57:54,764 APPROPRIATE SOCIAL SERVICES BUT 4347 02:57:54,830 --> 02:57:57,066 ALSO MAKE THE COMMUNITY CLINICAL 4348 02:57:57,133 --> 02:57:59,668 LINKAGE FOR THOSE WHO NEED 4349 02:57:59,735 --> 02:58:01,537 CLINICAL CARE. 4350 02:58:01,604 --> 02:58:04,040 WE BUILT A REPEATABLE 4351 02:58:04,106 --> 02:58:04,807 CONSULTATIVE RESOURCE, I'LL 4352 02:58:04,874 --> 02:58:07,443 SHARE WHAT WE'VE BEEN ABLE TO DO 4353 02:58:07,510 --> 02:58:11,280 IN CEAL WITH THIS EFFORT. 4354 02:58:11,347 --> 02:58:15,084 THE WHOLE PURPOSE OF THIS, 4355 02:58:15,151 --> 02:58:20,256 COMMUNITY ENGAGEMENT ALLIANCE 4356 02:58:20,322 --> 02:58:22,058 CONSULTATIVE RISK SOURCE TO 4357 02:58:22,124 --> 02:58:24,627 PROVIDE EXPERTISE FOR CLINICAL 4358 02:58:24,693 --> 02:58:27,029 TRIAL AND RESEARCH TEAMS HAVING 4359 02:58:27,096 --> 02:58:27,897 DIFFICULTY REACHING UNDERSERVED 4360 02:58:27,963 --> 02:58:31,200 COMMUNITIES, SO THE GOAL HERE 4361 02:58:31,267 --> 02:58:33,069 WAS TO OPTIMIZE INCLUSIVE 4362 02:58:33,135 --> 02:58:36,672 PARTICIPATION ACROSS THE ENTIRE 4363 02:58:36,739 --> 02:58:37,206 RESEARCH ECOSYSTEM. 4364 02:58:37,273 --> 02:58:40,176 I WANT TO SHOW ANOTHER EXAMPLE 4365 02:58:40,242 --> 02:58:42,011 OF THE RESEARCH WE SUPPORT IN 4366 02:58:42,078 --> 02:58:42,578 CEAL. 4367 02:58:42,645 --> 02:58:45,314 THIS IS A PILOT STUDY THAT WOULD 4368 02:58:45,381 --> 02:58:47,883 END I BELIEVE IN SEPTEMBER THIS 4369 02:58:47,950 --> 02:58:51,787 YEAR, BUT LOOKING AT HEALTH 4370 02:58:51,854 --> 02:58:52,655 KNOWLEDGE MONITORING, DEVELOPING 4371 02:58:52,721 --> 02:58:53,956 TAILORED RESPONSES THAT WOULD 4372 02:58:54,023 --> 02:58:56,025 TACKLE MUCH OF THE 4373 02:58:56,092 --> 02:58:56,725 MISINFORMATION AND 4374 02:58:56,792 --> 02:58:59,028 DISINFORMATION THAT WE FEAR. 4375 02:58:59,095 --> 02:59:01,330 BUT, AGAIN, THESE ARE ONLY THREE 4376 02:59:01,397 --> 02:59:03,399 EXAMPLES, THERE ARE ABOUT FOUR 4377 02:59:03,466 --> 02:59:05,067 OTHER KEY EXAMPLES AND SEVERAL 4378 02:59:05,134 --> 02:59:11,073 ARE SHOWN HERE IN THE COLORED 4379 02:59:11,140 --> 02:59:11,340 CIRCLES. 4380 02:59:11,407 --> 02:59:16,345 BLUE ARE THE STATES, 21 TEAMS, 4381 02:59:16,412 --> 02:59:17,480 AND INDIVIDUAL CEAL PROGRAMS, 4382 02:59:17,546 --> 02:59:20,182 FOR EXAMPLE, IN YELLOW ARE THE 4383 02:59:20,249 --> 02:59:23,285 SITES WHERE WE SUPPORT COMMUNITY 4384 02:59:23,352 --> 02:59:24,353 IMPLEMENTATION PROGRAM TO 4385 02:59:24,420 --> 02:59:26,922 PROMOTE MATERNAL HEALTH. 4386 02:59:26,989 --> 02:59:30,826 WE ALSO HAVE IN THE CYAN CIRCLE 4387 02:59:30,893 --> 02:59:33,329 ANOTHER COMMUNITY IMPLEMENTATION 4388 02:59:33,395 --> 02:59:34,763 PROGRAM CENTERED AROUND 4389 02:59:34,830 --> 02:59:35,764 PROMOTING IMPROVED PREGNANCY 4390 02:59:35,831 --> 02:59:36,031 OUTCOMES. 4391 02:59:36,098 --> 02:59:37,933 YOU ALL ARE FAMILIAR WITH THE 4392 02:59:38,000 --> 02:59:42,872 HUGE DISPARITIES THAT WE HAVE IN 4393 02:59:42,938 --> 02:59:44,006 MATERNAL MORTALITY AND NEAR 4394 02:59:44,073 --> 02:59:45,841 DEATH AND NEAR MISSES. 4395 02:59:45,908 --> 02:59:48,043 WE HAVE ANOTHER EFFORT IN 4396 02:59:48,110 --> 02:59:49,778 CLIMATE AND HEALTH. 4397 02:59:49,845 --> 02:59:52,615 PARTICULAR EFFORT FOCUSED ON 4398 02:59:52,681 --> 02:59:58,320 AMERICAN INDIAN AND ALASKA 4399 02:59:58,387 --> 02:59:59,855 NATIVE AND HAWAIIAN AND PACIFIC 4400 02:59:59,922 --> 03:00:01,190 ISLAND ENHANCEMENT. 4401 03:00:01,257 --> 03:00:03,025 AGAIN, THESE PROGRAMS IN 4402 03:00:03,092 --> 03:00:04,226 ADDITION TO THE BACKBONE 4403 03:00:04,293 --> 03:00:07,730 REGIONAL TEAMS WE SUPPORT. 4404 03:00:07,796 --> 03:00:10,900 THIS IS A BRIEF OVERVIEW OF SOME 4405 03:00:10,966 --> 03:00:13,736 PRIORITIES AND MAIN SERVICES WE 4406 03:00:13,802 --> 03:00:17,573 PROVIDE BUT IMPORTANTLY WE WANT 4407 03:00:17,640 --> 03:00:18,674 TO LISTEN AND UNDERSTAND 4408 03:00:18,741 --> 03:00:20,843 COMMUNITIES WITH REFERENCE TO 4409 03:00:20,910 --> 03:00:22,945 CHALLENGES, THE OPPORTUNITIES, 4410 03:00:23,012 --> 03:00:25,581 ALSO ADVANCED COMMUNITY ENGAGED 4411 03:00:25,648 --> 03:00:27,316 RESEARCH, WITH PARTICULAR 4412 03:00:27,383 --> 03:00:30,819 EMPHASIS ON CHANGING PUBLIC 4413 03:00:30,886 --> 03:00:31,754 HEALTH BEHAVIORS, FEBRUARY IS 4414 03:00:31,820 --> 03:00:33,222 AMERICAN HEART MONTH. 4415 03:00:33,289 --> 03:00:36,325 WE HAVE MORE THAN 75 YEARS OF 4416 03:00:36,392 --> 03:00:39,695 OUTSTANDING RESEARCH AROUND THE 4417 03:00:39,762 --> 03:00:41,330 RISKS OF HEART DISEASE YET THE 4418 03:00:41,397 --> 03:00:42,765 VAST MAJORITY OF LIFESTYLES AND 4419 03:00:42,831 --> 03:00:44,066 BEHAVIORS AND ACCESS TO CARE 4420 03:00:44,133 --> 03:00:46,502 THAT WOULD LEAD TO IMPROVED 4421 03:00:46,569 --> 03:00:48,470 HEART HEALTH WE'RE STILL LAGGING 4422 03:00:48,537 --> 03:00:49,071 BEHIND. 4423 03:00:49,138 --> 03:00:51,540 SO THE PLATFORM WE BUILT IS 4424 03:00:51,607 --> 03:00:54,910 REALLY ADAPTABLE TO MANY OF THE 4425 03:00:54,977 --> 03:00:58,614 CHALLENGES IN CHRONIC 4426 03:00:58,681 --> 03:01:00,382 CONDITIONS, ESPECIALLY 4427 03:01:00,449 --> 03:01:03,018 ADDRESSING THEM, WORKING 4428 03:01:03,085 --> 03:01:05,321 COLLABORATIVELY WITH THE 4429 03:01:05,387 --> 03:01:06,088 COMMUNITIES. 4430 03:01:06,155 --> 03:01:07,156 I'VE HIGHLIGHTED HELP KNOWLEDGE 4431 03:01:07,223 --> 03:01:09,892 SYSTEM, I WANT TO GET A LITTLE 4432 03:01:09,959 --> 03:01:11,860 BIT MORE INFORMATION ON WHAT 4433 03:01:11,927 --> 03:01:12,962 WE'RE DOING THERE. 4434 03:01:13,028 --> 03:01:15,798 THE PURPOSE OF THE PROGRAM WAS 4435 03:01:15,864 --> 03:01:19,301 TO TEST FEASIBILITY OF AN 4436 03:01:19,368 --> 03:01:20,736 NIH-FUNDED AND EXISTING 4437 03:01:20,803 --> 03:01:21,937 COMMUNITY MONITORING AND 4438 03:01:22,004 --> 03:01:22,504 RESPONSE SYSTEM. 4439 03:01:22,571 --> 03:01:24,907 WHAT ARE THEY MONITORING? 4440 03:01:24,974 --> 03:01:27,743 THEY ARE MONITORING THIS 4441 03:01:27,810 --> 03:01:29,144 INFORMATION AND PROVIDE 4442 03:01:29,211 --> 03:01:31,013 SCIENCE-BASED RESPONSES THAT CAN 4443 03:01:31,080 --> 03:01:32,648 HELP COMMUNITIES KNOW WHAT IS 4444 03:01:32,715 --> 03:01:35,384 TRUE, WHAT IS FALSE, AND 4445 03:01:35,451 --> 03:01:36,919 HOPEFULLY PROMOTE THE ENTIRE 4446 03:01:36,986 --> 03:01:40,222 COMMUNITY IN TERMS OF SCIENCE 4447 03:01:40,289 --> 03:01:46,662 AND EVIDENCE BASED KNOWLEDGE. 4448 03:01:46,729 --> 03:01:48,163 THE PROGRAM BUILDS ON THE I 4449 03:01:48,230 --> 03:01:50,299 HEART ST. LOUIS HEALTH 4450 03:01:50,366 --> 03:01:51,934 MONITORING AND RESPONSE SYSTEM. 4451 03:01:52,001 --> 03:01:53,335 WILL RUN INTO SEPTEMBER. 4452 03:01:53,402 --> 03:01:55,537 WE'RE HOPING WHAT WE LEARN FROM 4453 03:01:55,604 --> 03:01:59,108 THIS PILOT AS TO BEST STRATEGIES 4454 03:01:59,174 --> 03:02:01,110 TO GET SIZE-BASED KNOWLEDGE OUT 4455 03:02:01,176 --> 03:02:02,211 INTO THE COMMUNITIES COULD BE 4456 03:02:02,278 --> 03:02:04,847 SOMETHING THAT WE CAN SCALE UP 4457 03:02:04,913 --> 03:02:06,715 AND SPREAD. 4458 03:02:06,782 --> 03:02:09,118 SO, THESE ARE FOUR MAIN AREAS I 4459 03:02:09,184 --> 03:02:11,287 BRIEFLY WANTED TO HIGHLIGHT. 4460 03:02:11,353 --> 03:02:14,156 THERE WAS SOME MONITORING OF THE 4461 03:02:14,223 --> 03:02:15,257 RESPONSE SYSTEM ITSELF, 4462 03:02:15,324 --> 03:02:16,659 COORDINATING CENTER ALSO 4463 03:02:16,725 --> 03:02:17,893 PROVIDES TRAINING, COORDINATION 4464 03:02:17,960 --> 03:02:19,528 AND OVERSIGHT, AS WELL AS SOME 4465 03:02:19,595 --> 03:02:21,930 OF THE KEY ASPECTS OF DATA IN 4466 03:02:21,997 --> 03:02:24,566 TERMS OF RESEARCH. 4467 03:02:24,633 --> 03:02:26,969 WE HAVE BLUE RIBBON PANEL THAT 4468 03:02:27,036 --> 03:02:29,371 PROVIDES GUIDANCE AS TO THE BEST 4469 03:02:29,438 --> 03:02:31,940 STRATEGIES TO ADOPT, AND WE HAVE 4470 03:02:32,007 --> 03:02:34,576 A PARTNERSHIP WITH ANNENBERG 4471 03:02:34,643 --> 03:02:38,714 PUBLIC POLICY CENTER, UNIVERSITY 4472 03:02:38,781 --> 03:02:40,015 OF PENNSYLVANIA, AND ESPECIALLY 4473 03:02:40,082 --> 03:02:41,450 USING ITS EXTENSIVE KNOWLEDGE 4474 03:02:41,517 --> 03:02:45,020 AND FACT CHECK AND SCIENCE CHECK 4475 03:02:45,087 --> 03:02:45,821 PROJECT. 4476 03:02:45,888 --> 03:02:47,790 SO, THIS IS ONE EXAMPLE OF WHAT 4477 03:02:47,856 --> 03:02:50,025 WE'VE SEEN ON THE DASHBOARD, ON 4478 03:02:50,092 --> 03:02:54,663 THE EYE HEART ST. LOUIS. 4479 03:02:54,730 --> 03:02:57,299 I USED THE EXAMPLES, UPDATED AS 4480 03:02:57,366 --> 03:02:58,300 OF JANUARY 24. 4481 03:02:58,367 --> 03:03:00,035 WHEN YOU GO TO THAT LINK AND 4482 03:03:00,102 --> 03:03:04,506 HERE IS THE LINK, YOU CAN SIGN 4483 03:03:04,573 --> 03:03:06,442 UP FOR ALERTS, THEY WILL A 4484 03:03:06,508 --> 03:03:08,277 SERIES UP TO 10 KEY MESSAGES 4485 03:03:08,344 --> 03:03:11,580 HEARD IN THE COMMUNITY IN 4486 03:03:11,647 --> 03:03:13,749 ST. LOUIS, AND IF YOU CLICK ON 4487 03:03:13,816 --> 03:03:15,951 ANY ONE OF THEM, IT WILL TAKE 4488 03:03:16,018 --> 03:03:20,322 YOU TO WHAT THAT MESSAGE IS, AND 4489 03:03:20,389 --> 03:03:25,227 WHAT THE EVIDENCE SUGGESTS, SO 4490 03:03:25,294 --> 03:03:28,063 FOR THIS MESSAGE AROUND DNA 4491 03:03:28,130 --> 03:03:28,897 FRAGMENTS IN mRNA VACCINES 4492 03:03:28,964 --> 03:03:30,499 CHANGE YOUR DNA AND CAN AFFECT 4493 03:03:30,566 --> 03:03:31,800 YOUR HEALTH AND WHY IT'S 4494 03:03:31,867 --> 03:03:33,202 IMPORTANT DON'T EVER GET IT, 4495 03:03:33,268 --> 03:03:37,039 WELL, IS IT TRUE OR NOT TRUE? 4496 03:03:37,106 --> 03:03:39,341 AND THE PROGRAM SHOWS YOU THE 4497 03:03:39,408 --> 03:03:40,976 LATEST EVIDENCE SUGGESTS THE 4498 03:03:41,043 --> 03:03:42,511 CLAIM IS FALSE. 4499 03:03:42,578 --> 03:03:45,347 YOU CAN CLICK ON THIS TO GET 4500 03:03:45,414 --> 03:03:46,715 ADDITIONAL INFORMATION. 4501 03:03:46,782 --> 03:03:49,852 IT ALSO GIVES YOU AND EQUIPS YOU 4502 03:03:49,918 --> 03:03:51,387 WITH MESSAGES YOU CAN SHARE WITH 4503 03:03:51,453 --> 03:03:54,323 FAMILY AND FRIENDS THAT THE 4504 03:03:54,390 --> 03:03:56,191 CONCERNS ABOUT COVID VACCINE'S 4505 03:03:56,258 --> 03:03:58,394 INTERFERENCE WITH HUMAN DNA IS 4506 03:03:58,460 --> 03:04:00,028 SIMPLY NOT SUPPORTED BY 4507 03:04:00,095 --> 03:04:00,295 RESEARCH. 4508 03:04:00,362 --> 03:04:02,097 AND THAT COVID VACCINE EVEN 4509 03:04:02,164 --> 03:04:09,638 THOUGH IT HAS SMALL QUANTITIES 4510 03:04:09,705 --> 03:04:10,506 OF DNA FRAGMENTS DEFINITELY 4511 03:04:10,572 --> 03:04:12,941 CANNOT ENTER DNA AND PROVIDES 4512 03:04:13,008 --> 03:04:18,313 PLAIN LANGUAGE MESSAGES THAT 4513 03:04:18,380 --> 03:04:20,182 EMPOWERS THE COMMUNITY ECHOING 4514 03:04:20,249 --> 03:04:20,916 THIS MISINFORMATION, ONE 4515 03:04:20,983 --> 03:04:21,150 EXAMPLE. 4516 03:04:21,216 --> 03:04:23,886 THIS IS ONE OF THE FUNDING 4517 03:04:23,952 --> 03:04:25,954 OPPORTUNITIES I SAW ON THE NLM 4518 03:04:26,021 --> 03:04:26,955 WEBSITE. 4519 03:04:27,022 --> 03:04:30,659 I WAS THRILLED AND I SAID TO 4520 03:04:30,726 --> 03:04:32,661 MYSELF, JUST IMAGINE THE IMPACT 4521 03:04:32,728 --> 03:04:36,465 WE COULD HAVE WITH A NETWORK OF 4522 03:04:36,532 --> 03:04:39,735 NLM REGIONS ALL COLLECTIVELY 4523 03:04:39,802 --> 03:04:40,836 WORKING IN PARTNERSHIP WITH 4524 03:04:40,903 --> 03:04:43,038 REGIONAL TEAMS TO USE WHAT WE 4525 03:04:43,105 --> 03:04:45,674 LEARNED FROM THE HEALTH 4526 03:04:45,741 --> 03:04:48,644 KNOWLEDGE MONITORING TO REALLY 4527 03:04:48,710 --> 03:04:49,378 SPREAD TRUSTWORTHY HEALTH 4528 03:04:49,445 --> 03:04:52,581 INFORMATION IN COMMUNITIES 4529 03:04:52,648 --> 03:04:54,349 ACROSS THE COUNTRY, REALLY A 4530 03:04:54,416 --> 03:04:55,517 UNIQUE OPPORTUNITY. 4531 03:04:55,584 --> 03:04:58,153 SO WE'VE BEEN DOING THIS NOW FOR 4532 03:04:58,220 --> 03:05:00,656 THREE YEARS, FOR OUR YEAR 4 4533 03:05:00,722 --> 03:05:05,060 WE'VE DEFINITELY MADE A PIVOT 4534 03:05:05,127 --> 03:05:06,595 FROM ACUTE MANIFESTATIONS OF 4535 03:05:06,662 --> 03:05:12,167 COVID TO REALLY ADDRESS CHRONIC 4536 03:05:12,234 --> 03:05:13,368 CONDITIONS, ESPECIALLY THE 4537 03:05:13,435 --> 03:05:15,671 ABILITY TO DO RIGOROUS AND 4538 03:05:15,737 --> 03:05:16,772 MEANINGFUL COMMUNITY ENGAGED 4539 03:05:16,839 --> 03:05:21,710 RESEARCH THAT WILL PROMOTE 4540 03:05:21,777 --> 03:05:23,645 HEALTH EQUITY, PREVENTION AND 4541 03:05:23,712 --> 03:05:25,747 TREATMENT AS WELL AS CONTROL, 4542 03:05:25,814 --> 03:05:28,817 AND REALLY REDUCE DISPARITIES, 4543 03:05:28,884 --> 03:05:30,752 THROUGH ADDRESSING UPSTREAM 4544 03:05:30,819 --> 03:05:33,422 SOCIAL AND STRUCTURAL 4545 03:05:33,489 --> 03:05:34,490 DETERMINANTS OF HEALTH, 4546 03:05:34,556 --> 03:05:35,491 KNOWLEDGE IS CRUCIAL. 4547 03:05:35,557 --> 03:05:38,126 WE WANT TO PROMOTE AWARENESS IN 4548 03:05:38,193 --> 03:05:43,599 EDUCATION AS WELL AS HELP 4549 03:05:43,665 --> 03:05:46,869 KNOWLEDGE THROUGH EAVED -- 4550 03:05:46,935 --> 03:05:47,769 EVIDENCE-BASED STRATEGIES. 4551 03:05:47,836 --> 03:05:49,071 INVESTIGATORS ARE GOING THROUGH 4552 03:05:49,137 --> 03:05:49,505 APPLICATIONS. 4553 03:05:49,571 --> 03:05:51,907 MY HOPE IS THERE WILL BE STRONG 4554 03:05:51,974 --> 03:05:54,743 PARTNERSHIPS BETWEEN OUR 4555 03:05:54,810 --> 03:05:57,145 LIAISONS AND NLM PROGRAM OFFICER 4556 03:05:57,212 --> 03:06:02,084 LIAISONS SO WE CAN REALLY MAKE 4557 03:06:02,150 --> 03:06:02,351 PROGRESS. 4558 03:06:02,417 --> 03:06:07,222 LET ME TACKLE WHY DATA SCIENCE 4559 03:06:07,289 --> 03:06:07,956 AND BIOINFORMATICS, AN AREA 4560 03:06:08,023 --> 03:06:10,125 WHERE HE LOOK TO THE NATIONAL 4561 03:06:10,192 --> 03:06:11,627 LIBRARY OF MEDICINE FOR MUCH 4562 03:06:11,693 --> 03:06:13,462 SUPPORT AND MUCH HELP. 4563 03:06:13,529 --> 03:06:15,297 WHY IT'S SUCH A CRUCIAL ROLE. 4564 03:06:15,364 --> 03:06:17,199 AGAIN, I DON'T NEED TO EXPLAIN 4565 03:06:17,266 --> 03:06:20,068 THAT TO YOU, ONLY TO MENTION 4566 03:06:20,135 --> 03:06:23,438 THAT WE ARE REALLY COUNTING ON 4567 03:06:23,505 --> 03:06:24,706 EXPERTISE WITHIN THE NLM AND 4568 03:06:24,773 --> 03:06:28,043 PROGRAMS YOU BUILT SO THAT WE 4569 03:06:28,110 --> 03:06:31,013 CAN REALLY INCREASE COMMUNITY 4570 03:06:31,079 --> 03:06:32,548 ACCESS TO TRUSTED SCIENCE-BASED 4571 03:06:32,614 --> 03:06:33,181 HEALTH INFORMATION. 4572 03:06:33,248 --> 03:06:35,417 WE WANT TO MAKE SURE THAT WE CAN 4573 03:06:35,484 --> 03:06:37,653 MAKE A LOCAL LEVEL HEALTH DATA 4574 03:06:37,719 --> 03:06:39,221 MORE ACCESSIBLE TO THE 4575 03:06:39,288 --> 03:06:41,723 COMMUNITIES THEMSELVES, AS WELL 4576 03:06:41,790 --> 03:06:44,059 AS TO RESEARCHERS THAT WE 4577 03:06:44,126 --> 03:06:44,459 SUPPORT. 4578 03:06:44,526 --> 03:06:47,195 IMPORTANTLY, WE WANT TO PROVIDE 4579 03:06:47,262 --> 03:06:50,766 INFORMATIC TOOLS AND TECHNOLOGY 4580 03:06:50,832 --> 03:06:52,334 THAT WOULD FACILITATE LOCAL 4581 03:06:52,401 --> 03:06:54,736 LEVEL COMMUNITY DATA ANALYSIS 4582 03:06:54,803 --> 03:06:57,472 AND THE ABILITY TO VISUALIZE 4583 03:06:57,539 --> 03:06:59,341 THEIR OWN DATA, ESPECIALLY 4584 03:06:59,408 --> 03:07:01,743 VISUALIZE THE TRENDS OF WHAT THE 4585 03:07:01,810 --> 03:07:05,013 DATA ABOUT YOUR COMMUNITIES LOOK 4586 03:07:05,080 --> 03:07:05,881 LIKE. 4587 03:07:05,948 --> 03:07:07,883 AND CERTAINLY EXPERTISE THAT NLM 4588 03:07:07,950 --> 03:07:10,285 HAS IN PROVIDING GUIDANCE AND 4589 03:07:10,352 --> 03:07:13,989 ETHICAL CONSIDERATIONS, ON DATA 4590 03:07:14,056 --> 03:07:15,424 SHARING, AND PRIVACY CONCERNS, 4591 03:07:15,490 --> 03:07:17,059 ALL REALLY IMPORTANT. 4592 03:07:17,125 --> 03:07:19,795 I'M FROM THE EXTRAMURAL RESEARCH 4593 03:07:19,861 --> 03:07:20,262 COMMUNITY. 4594 03:07:20,329 --> 03:07:21,196 AND HOPING THAT IN OUR 4595 03:07:21,263 --> 03:07:23,732 PARTNERSHIP WE CAN GET TOGETHER 4596 03:07:23,799 --> 03:07:24,733 TO REALLY ADVANCE EXTRAMURAL 4597 03:07:24,800 --> 03:07:29,905 RESEARCH WHEN IT COMES TO 4598 03:07:29,972 --> 03:07:31,073 COMMUNITY ENGAGEMENT. 4599 03:07:31,139 --> 03:07:33,342 NOT SURPRISINGLY, THESE ARE ALSO 4600 03:07:33,408 --> 03:07:35,344 IMPORTANT PRIORITIES IN THE NLM 4601 03:07:35,410 --> 03:07:38,814 STRATEGIC PLAN. 4602 03:07:38,880 --> 03:07:39,815 COMMUNITY ENGAGEMENT THROUGH 4603 03:07:39,881 --> 03:07:41,650 NATIONAL NETWORK, SOME WORK YOU 4604 03:07:41,717 --> 03:07:43,518 DO WITH "ALL OF US," THERE'S A 4605 03:07:43,585 --> 03:07:45,621 LOT WE LEARN FROM IT. 4606 03:07:45,687 --> 03:07:47,589 IN FACT, FOUR YEARS AGO, NEARLY 4607 03:07:47,656 --> 03:07:49,891 FOUR YEARS AGO WHEN WE STARTED 4608 03:07:49,958 --> 03:07:51,426 THIS EFFORT WE LOOKED TO THE 4609 03:07:51,493 --> 03:07:52,628 "ALL OF US" PROGRAM AND WHAT 4610 03:07:52,694 --> 03:07:54,930 THEY HAVE DONE IN COMMUNITY 4611 03:07:54,997 --> 03:07:55,230 ENGAGEMENT. 4612 03:07:55,297 --> 03:07:59,401 AND WE THINK A PARTNERSHIP LIKE 4613 03:07:59,468 --> 03:08:00,402 THIS WOULD REALLY ADVANCE 4614 03:08:00,469 --> 03:08:03,138 EFFORTS IN YOUR OWN STRATEGIC 4615 03:08:03,205 --> 03:08:03,739 PLAN WORKFORCE DEVELOPMENT IS 4616 03:08:03,805 --> 03:08:04,973 IMPORTANT TO YOU. 4617 03:08:05,040 --> 03:08:06,842 I CANNOT THINK OF ANYTHING MORE 4618 03:08:06,908 --> 03:08:10,912 IMPORTANT THAN OUR ABILITY AS AN 4619 03:08:10,979 --> 03:08:12,648 AGENCY TO SUPPORT WORKFORCE 4620 03:08:12,714 --> 03:08:13,982 DEVELOPMENT, PARTICULARLY FOR 4621 03:08:14,049 --> 03:08:15,183 COMMUNITY HEALTH WORKERS, SOCIAL 4622 03:08:15,250 --> 03:08:17,152 WORKERS, WHO GET THE WORD OUT, 4623 03:08:17,219 --> 03:08:19,454 WHO SUPPORT THE COMMUNITIES, AND 4624 03:08:19,521 --> 03:08:21,089 WHO PLAY CRUCIAL ROLES IN 4625 03:08:21,156 --> 03:08:22,658 LINKING COMMUNITIES TO THE CARE 4626 03:08:22,724 --> 03:08:24,826 THEY NEED. 4627 03:08:24,893 --> 03:08:28,764 AS WELL AS BENEFIT FROM FINDINGS 4628 03:08:28,830 --> 03:08:29,765 FROM RESEARCH. 4629 03:08:29,831 --> 03:08:33,802 I'LL CONCLUDE WITH A FINAL 4630 03:08:33,869 --> 03:08:37,739 SECTION ON A VISION FOR A 4631 03:08:37,806 --> 03:08:39,508 STRATEGIC ALLIANCE OF CEAL AND 4632 03:08:39,574 --> 03:08:42,110 NATIONAL LIBRARY OF MEDICINE. 4633 03:08:42,177 --> 03:08:44,112 MOST IMPORTANT IS REALLY GROWING 4634 03:08:44,179 --> 03:08:46,214 A TRUST IN SCIENCE, AND 4635 03:08:46,281 --> 03:08:50,786 CONTINUING TO GROW THAT TRUST IN 4636 03:08:50,852 --> 03:08:52,454 RESEARCH, THAT WILL FURTHER 4637 03:08:52,521 --> 03:08:53,755 ENHANCE PARTICIPATION, NOT JUST 4638 03:08:53,822 --> 03:08:56,925 IN THE RESEARCH, BUT ALSO IN THE 4639 03:08:56,992 --> 03:08:59,227 BENEFITS OF THE RESEARCH. 4640 03:08:59,294 --> 03:09:01,096 INCLUSIVE EXCELLENCE, MAKING 4641 03:09:01,163 --> 03:09:03,065 SURE THAT WE PROVIDED 4642 03:09:03,131 --> 03:09:05,100 OPPORTUNITIES TO ALL BOYS AND 4643 03:09:05,167 --> 03:09:07,636 GIRLS, MEN AND WOMEN, FROM ALL 4644 03:09:07,703 --> 03:09:09,404 RACE, ETHNIC GROUPS, TO MAKE 4645 03:09:09,471 --> 03:09:11,473 SURE WE REALLY BUILD THE 4646 03:09:11,540 --> 03:09:14,776 COMMUNITY THAT WE CAN BUILD. 4647 03:09:14,843 --> 03:09:18,380 HEALTH INFORMATION ACCESS AND 4648 03:09:18,447 --> 03:09:19,247 LITERACY ARE CRUCIAL. 4649 03:09:19,314 --> 03:09:22,317 OF COURSE DATA SHARING, DATA 4650 03:09:22,384 --> 03:09:23,618 ANALYSIS, INTERPRETATION, FOR 4651 03:09:23,685 --> 03:09:25,487 COMMUNITY HEALTH RESEARCH, THE 4652 03:09:25,554 --> 03:09:26,254 TOOLS AND TECHNOLOGY 4653 03:09:26,321 --> 03:09:29,091 DEVELOPMENT, AND THAT CAN MAKE 4654 03:09:29,157 --> 03:09:31,626 IT MUCH EASIER, MUCH FASTER, FOR 4655 03:09:31,693 --> 03:09:33,328 COMMUNITIES TO GET FROM DATA TO 4656 03:09:33,395 --> 03:09:35,864 ACTION, THAT'S GOING TO BE KEY. 4657 03:09:35,931 --> 03:09:38,734 MAKING SURE THAT WE SPREAD 4658 03:09:38,800 --> 03:09:39,701 SCIENCE-BASED HEALTH 4659 03:09:39,768 --> 03:09:43,238 COMMUNICATION, THAT WE CONTINUE 4660 03:09:43,305 --> 03:09:44,139 TO PROVE OURSELVES TRUSTWORTHY 4661 03:09:44,206 --> 03:09:47,275 SO THAT THE LONG HISTORY OF 4662 03:09:47,342 --> 03:09:50,879 TRUST YOU HAVE, THAT WE'VE HAD 4663 03:09:50,946 --> 03:09:53,715 AT NIH CAN CONTINUE TO GROW. 4664 03:09:53,782 --> 03:09:54,449 CERTAINLY EVALUATION AND 4665 03:09:54,516 --> 03:09:55,951 ASSESSMENT OF IMPACT SO WE CAN 4666 03:09:56,017 --> 03:09:57,586 DO MORE AND MORE OF WHAT WORKS, 4667 03:09:57,652 --> 03:10:02,057 DO LESS AND LESS OF WHAT HAS 4668 03:10:02,124 --> 03:10:03,358 BEEN INEFFECTIVE. 4669 03:10:03,425 --> 03:10:04,893 THERE'S ONE EXAMPLE OF THE 4670 03:10:04,960 --> 03:10:06,428 PROGRAMS THAT I MENTIONED 4671 03:10:06,495 --> 03:10:06,661 EARLIER. 4672 03:10:06,728 --> 03:10:09,831 THAT MAY EVEN BE TODAY OF VALUE 4673 03:10:09,898 --> 03:10:12,000 TO NLM AND I'M FULLY COMMITTED. 4674 03:10:12,067 --> 03:10:14,870 OUR PROGRAM TEAM IS VERY 4675 03:10:14,936 --> 03:10:15,771 COMMITTED, WORKING WITH THE 4676 03:10:15,837 --> 03:10:16,872 NATIONAL LIBRARY OF MEDICINE, TO 4677 03:10:16,938 --> 03:10:18,940 ADVANCE THIS. 4678 03:10:19,007 --> 03:10:20,242 THIS IS OUR CONSULTATIVE 4679 03:10:20,308 --> 03:10:21,042 RESOURCE. 4680 03:10:21,109 --> 03:10:25,380 WE HAVE SOME TERRIFIC LEADERS, 4681 03:10:25,447 --> 03:10:27,349 TREMENDOUS BACKGROUND, FROM 4682 03:10:27,415 --> 03:10:29,651 MOLECULAR BIOLOGY TO FAMILY 4683 03:10:29,718 --> 03:10:30,519 MEDICINE, LEADING THIS WORK. 4684 03:10:30,585 --> 03:10:33,822 WE TAP INTO THE ENERGY AND POWER 4685 03:10:33,889 --> 03:10:36,324 AND EXPERTISE OF COMMUNITIES TO 4686 03:10:36,391 --> 03:10:37,959 REALLY SHARE WITH RESEARCHERS 4687 03:10:38,026 --> 03:10:38,960 WHAT THE COMMUNITY RESOURCES 4688 03:10:39,027 --> 03:10:40,495 ARE, WHAT THE COMMUNITY 4689 03:10:40,562 --> 03:10:43,765 CHALLENGES ARE, SO THAT WE CAN 4690 03:10:43,832 --> 03:10:46,501 DO BETTER THAN SOME OF THE 4691 03:10:46,568 --> 03:10:49,771 LEVELS OF INCLUSIVENESS THAT OUR 4692 03:10:49,838 --> 03:10:51,006 RESEARCH HAS TODAY. 4693 03:10:51,072 --> 03:10:53,408 LEER EXAMPLES OF SOME NIH-FUNDED 4694 03:10:53,475 --> 03:10:56,812 PROGRAMS THAT HAVE BENEFITED 4695 03:10:56,878 --> 03:10:58,914 FROM THAT CONSULTATION. 4696 03:10:58,980 --> 03:11:02,951 ReCOVer IS ONE, ACTIVE SIX 4697 03:11:03,018 --> 03:11:04,920 MUCH EARLIER ON. 4698 03:11:04,986 --> 03:11:05,921 I'LL CONCLUDE BY HIGHLIGHTING A 4699 03:11:05,987 --> 03:11:08,857 FEW THINGS, ALL OF THIS IS VERY 4700 03:11:08,924 --> 03:11:10,258 WELL KNOWN TO YOU, AN IMPORTANT 4701 03:11:10,325 --> 03:11:12,928 PART OF YOUR OWN MISSION. 4702 03:11:12,994 --> 03:11:15,096 WE KNOW THAT NATIONAL LIBRARY OF 4703 03:11:15,163 --> 03:11:17,599 MEDICINE CONTINUES TO BE A 4704 03:11:17,666 --> 03:11:19,801 TRUSTED AND RESPECTED NATIONAL 4705 03:11:19,868 --> 03:11:20,368 TREASURE. 4706 03:11:20,435 --> 03:11:22,103 YOUR SERVICE TO SCIENCE AND 4707 03:11:22,170 --> 03:11:24,306 SOCIETY FOR MANY, MANY, MANY 4708 03:11:24,372 --> 03:11:26,107 YEARS, VERY WELL RECOGNIZED. 4709 03:11:26,174 --> 03:11:28,777 WHAT WE'RE TRYING TO DO AT CEAL 4710 03:11:28,844 --> 03:11:30,979 IS TO USE WHAT THE NATIONAL 4711 03:11:31,046 --> 03:11:33,815 ACADEMY OF MEDICINE CALLED 4712 03:11:33,882 --> 03:11:35,116 MEANINGFUL COMMUNITY ENGAGEMENT 4713 03:11:35,183 --> 03:11:37,652 IN RESEARCH, SO THAT WE CAN 4714 03:11:37,719 --> 03:11:38,987 IMPROVE HEALTH OUTCOMES AND 4715 03:11:39,054 --> 03:11:41,623 PROMOTE HEALTH EQUITY IN THESE 4716 03:11:41,690 --> 03:11:42,090 COMMUNITIES. 4717 03:11:42,157 --> 03:11:45,227 WE REALLY HAVE A UNIQUE 4718 03:11:45,293 --> 03:11:45,927 OPPORTUNITY TO BRING RESOURCES 4719 03:11:45,994 --> 03:11:55,170 OF THE 21ST CENTURY LIBRARY TO 4720 03:11:55,237 --> 03:11:56,304 UNDERSERVED COMMUNITIES, MANY IN 4721 03:11:56,371 --> 03:11:58,240 RURAL AREAS, WHO DON'T HAVE 4722 03:11:58,306 --> 03:12:00,575 ACCESS TO THE RESOURCES THAT WE 4723 03:12:00,642 --> 03:12:01,643 HAVE HERE IN BETHESDA. 4724 03:12:01,710 --> 03:12:05,947 I ALWAYS THINK OF MY COLLEAGUES 4725 03:12:06,014 --> 03:12:09,417 IN MANY RURAL AREAS, ESPECIALLY 4726 03:12:09,484 --> 03:12:09,885 LOW- AND MIDDLE-INCOME 4727 03:12:09,951 --> 03:12:11,052 COUNTRIES, TRYING TO COMPETE FOR 4728 03:12:11,119 --> 03:12:13,922 THE SAME GRANTS THOSE OF US HERE 4729 03:12:13,989 --> 03:12:16,992 IN THE UNITED STATES COMPETE 4730 03:12:17,058 --> 03:12:17,392 FOR. 4731 03:12:17,459 --> 03:12:19,628 THAT LACK OF ACCESS AND INEQUITY 4732 03:12:19,694 --> 03:12:21,796 AND IMBALANCE IS SOMETHING THAT 4733 03:12:21,863 --> 03:12:23,431 I HOPE WHEN WE THINK OF OUR 4734 03:12:23,498 --> 03:12:24,633 COMMUNITIES WE SERVE IN THE 4735 03:12:24,699 --> 03:12:26,735 U.S., WE CAN DO OUR BEST TO 4736 03:12:26,801 --> 03:12:29,971 REALLY LEVEL THE PLAYING FIELD 4737 03:12:30,038 --> 03:12:33,208 SO THAT THE ACCESS, INNOVATION, 4738 03:12:33,275 --> 03:12:34,709 TECHNOLOGY DEVELOPMENT, CAN 4739 03:12:34,776 --> 03:12:35,377 REALLY SPEED IMPROVEMENTS IN 4740 03:12:35,443 --> 03:12:37,345 HEALTH SO THAT OUR COMMUNITIES 4741 03:12:37,412 --> 03:12:38,546 CAN THRIVE. 4742 03:12:38,613 --> 03:12:39,681 WE REALLY, REALLY, REALLY LOOK 4743 03:12:39,748 --> 03:12:41,283 FORWARD TO WORKING WITH THE 4744 03:12:41,349 --> 03:12:44,019 NATIONAL LIBRARY OF MEDICINE TO 4745 03:12:44,085 --> 03:12:48,490 PROMOTE HEALTH, TO ADVANCE 4746 03:12:48,556 --> 03:12:50,025 DISEASE PREVENTION, TREATMENT, 4747 03:12:50,091 --> 03:12:51,126 AND EVEN CURES. 4748 03:12:51,192 --> 03:12:53,428 SO THAT WE CAN PROMOTE HEALTH 4749 03:12:53,495 --> 03:12:59,134 EQUITY IN THE COMMUNITIES WE 4750 03:12:59,200 --> 03:12:59,768 SERVE. 4751 03:12:59,834 --> 03:13:03,505 OBVIOUSLY-- OOPS, THAT DIDN'T 4752 03:13:03,571 --> 03:13:04,105 SHOW. 4753 03:13:04,172 --> 03:13:06,207 IT'S SUPPOSED TO SHOW IMAGE OF 4754 03:13:06,274 --> 03:13:08,510 THE ISSUE WITH THE AMERICAN 4755 03:13:08,576 --> 03:13:14,349 GENERAL PUBLIC HEALTH, THAT HAS 4756 03:13:14,416 --> 03:13:15,550 27 ARTICLES ALL FOCUSED, I'LL 4757 03:13:15,617 --> 03:13:17,752 SEND A LINK SO CAN YOU HAVE 4758 03:13:17,819 --> 03:13:18,219 ACCESS. 4759 03:13:18,286 --> 03:13:21,289 THEY ARE ALL OPEN ACCESS. 4760 03:13:21,356 --> 03:13:23,558 WE THINK IT ADDS SUBSTANTIVELY 4761 03:13:23,625 --> 03:13:25,327 TO THE LITERATURE. 4762 03:13:25,393 --> 03:13:27,295 I WANT TO RECOGNIZE THE TEAM 4763 03:13:27,362 --> 03:13:30,465 THAT MADE THIS WORK POSSIBLE, 4764 03:13:30,532 --> 03:13:31,666 INCLUDING THE HELP FROM NATIONAL 4765 03:13:31,733 --> 03:13:34,836 LIBRARY OF MEDICINE. 4766 03:13:34,903 --> 03:13:36,705 OUR CO-CHAIRS, IC DIRECTORS, DR. 4767 03:13:36,771 --> 03:13:43,812 GIBBONS AND DR. PEREZ-STABLE, 4768 03:13:43,878 --> 03:13:46,881 FROM NIMHD AND NHLBI, SUBJECT 4769 03:13:46,948 --> 03:13:49,718 MATTER EXPERTS FROM ACROSS THE 4770 03:13:49,784 --> 03:13:52,354 NIH, PARTICULARLY GRATEFUL FOR 4771 03:13:52,420 --> 03:13:54,856 THE NON-NIH EXPERTS WHO SERVE ON 4772 03:13:54,923 --> 03:13:55,724 OUR STEERING COMMITTEE, 4773 03:13:55,790 --> 03:13:58,693 CO-CHAIRS OF OUR WORK GROUPS, 4774 03:13:58,760 --> 03:14:00,795 INTEREST GROUP, THEY PLAYED A 4775 03:14:00,862 --> 03:14:02,664 TREMENDOUS ROLE, ESPECIALLY IN 4776 03:14:02,731 --> 03:14:05,600 THE FIRST YEAR WHEN WE SPENT 4777 03:14:05,667 --> 03:14:07,902 HOURS OF MEETING IN ORDER TO 4778 03:14:07,969 --> 03:14:08,870 SYNTHESIZE WHAT WE HEARD FROM 4779 03:14:08,937 --> 03:14:11,740 COMMUNITIES AND MAKE SURE WE CAN 4780 03:14:11,806 --> 03:14:12,941 SERVE THE COMMUNITIES 4781 03:14:13,008 --> 03:14:13,274 APPROPRIATELY. 4782 03:14:13,341 --> 03:14:16,044 THIS IS A REAL GEM THAT WE HAVE. 4783 03:14:16,111 --> 03:14:17,445 WE HAVE SUBJECT MATTER EXPERTS 4784 03:14:17,512 --> 03:14:18,747 FROM ACROSS THE NIH. 4785 03:14:18,813 --> 03:14:21,916 I REALLY WANT TO HIGHLIGHT AND 4786 03:14:21,983 --> 03:14:24,119 THANK RICHARD PALMER FROM NLM 4787 03:14:24,185 --> 03:14:26,321 FOR SUPPORT OF OUR PROGRAM. 4788 03:14:26,388 --> 03:14:29,691 AND WE ARE FORTUNATE TO HAVE THE 4789 03:14:29,758 --> 03:14:32,327 OFFICE OF NHLBI DIRECTOR. 4790 03:14:32,394 --> 03:14:35,397 WE USE THE OTHER TRANSACTIONS 4791 03:14:35,463 --> 03:14:37,699 AUTHORITY, O.T., WHICH PROVIDES 4792 03:14:37,766 --> 03:14:39,267 TREMENDOUS FLEXIBILITY, MORE SO 4793 03:14:39,334 --> 03:14:41,970 THAN A GRANT OR CONTRACT OR 4794 03:14:42,037 --> 03:14:42,437 COOPERATIVE AGREEMENT. 4795 03:14:42,504 --> 03:14:44,172 AND THAT HAS BEEN THE REAL 4796 03:14:44,239 --> 03:14:45,807 SAVIOR IN THIS WORK. 4797 03:14:45,874 --> 03:14:48,109 THE ABILITY TO PIVOT WHEN 4798 03:14:48,176 --> 03:14:50,612 NECESSARY, THE ABILITY TO CHANGE 4799 03:14:50,678 --> 03:14:52,480 COURSE, ABILITY TO CHANGE 4800 03:14:52,547 --> 03:14:54,783 SPECIFIC AIMS, YOU'RE NOT TIED 4801 03:14:54,849 --> 03:14:57,318 INTO ANYTHING THAT YOU FUND IN 4802 03:14:57,385 --> 03:14:59,921 YEAR ONE BUT BEING ABLE TO WORK 4803 03:14:59,988 --> 03:15:01,589 WITH THE COMMUNITIES AND MAKE 4804 03:15:01,656 --> 03:15:03,124 CHANGE AS WE GO ALONG. 4805 03:15:03,191 --> 03:15:04,626 OFFICE OF DIRECTOR HAS BEEN 4806 03:15:04,692 --> 03:15:07,362 EXTREMELY HELPFUL. 4807 03:15:07,429 --> 03:15:07,896 PROGRAM MANAGEMENT OFFICE, 4808 03:15:07,962 --> 03:15:08,663 EXTREMELY, EXTREMELY SUPPORTIVE. 4809 03:15:08,730 --> 03:15:18,973 AND WE ALSO HAVE THE SUPPORT OF 4810 03:15:19,040 --> 03:15:20,942 THE DELOITTE AND CTAC. 4811 03:15:21,009 --> 03:15:23,344 I HOPE THE MESSAGE CAME ACROSS, 4812 03:15:23,411 --> 03:15:24,979 I WAS THRILLED WHEN I HAD THE 4813 03:15:25,046 --> 03:15:26,614 OPPORTUNITY TO SPEAK WITH YOU. 4814 03:15:26,681 --> 03:15:28,483 I HOPE IT WON'T BE THE LAST ONE. 4815 03:15:28,550 --> 03:15:31,653 THANK YOU VERY MUCH FOR INVITING 4816 03:15:31,719 --> 03:15:31,820 ME. 4817 03:15:31,886 --> 03:15:32,754 >> WONDERFUL. 4818 03:15:32,821 --> 03:15:34,489 THANK YOU SO MUCH, DR. MENSAH. 4819 03:15:34,556 --> 03:15:36,024 IT IS AN ABSOLUTE DELIGHT TO 4820 03:15:36,091 --> 03:15:37,192 HAVE YOU JOIN US TODAY. 4821 03:15:37,258 --> 03:15:39,027 I'M A BIG FAN OF YOUR WORK. 4822 03:15:39,094 --> 03:15:40,995 SO IT'S WONDERFUL TO HEAR MORE 4823 03:15:41,062 --> 03:15:42,831 ABOUT CEAL FROM YOUR PERSPECTIVE 4824 03:15:42,897 --> 03:15:43,932 AND ESPECIALLY THINKING ABOUT IT 4825 03:15:43,998 --> 03:15:45,467 IN THE CONTEXT OF THE WORK OF 4826 03:15:45,533 --> 03:15:48,002 THE NATIONAL LIBRARY OF 4827 03:15:48,069 --> 03:15:48,269 MEDICINE. 4828 03:15:48,336 --> 03:15:51,940 SO WE HAVE THE OPPORTUNITY TO 4829 03:15:52,006 --> 03:15:52,574 HAVE SOME DISCUSSION. 4830 03:15:52,640 --> 03:15:54,476 AND I'D LIKE TO WELCOME 4831 03:15:54,542 --> 03:15:56,978 MS. JENNIE LUCCA AND MR. PHILIP 4832 03:15:57,045 --> 03:15:58,513 WALKER WHO WILL BE FACILITATING 4833 03:15:58,580 --> 03:15:59,581 THAT DISCUSSION. 4834 03:15:59,647 --> 03:16:01,149 AND BEFORE THEY GET STARTED I 4835 03:16:01,216 --> 03:16:04,119 ALSO WANT TO POINT OUT THAT 4836 03:16:04,185 --> 03:16:05,520 DIANE HAS KINDLY PASTED SOME 4837 03:16:05,587 --> 03:16:10,225 LINKS TO THE SPECIAL ISSUE THAT 4838 03:16:10,291 --> 03:16:11,860 YOU MENTIONED, INCLUDED IN YOUR 4839 03:16:11,926 --> 03:16:12,193 PRESENTATION. 4840 03:16:12,260 --> 03:16:16,831 I WILL TURN IT OVER TO JENNIE 4841 03:16:16,898 --> 03:16:17,599 AND PHILIP. 4842 03:16:17,665 --> 03:16:19,567 >> I'M HAPPY TO GO FIRST. 4843 03:16:19,634 --> 03:16:22,537 THANK YOU, DR. MENSAH. 4844 03:16:22,604 --> 03:16:23,738 THAT WAS REALLY FASCINATING. 4845 03:16:23,805 --> 03:16:25,473 I'VE BEEN FAMILIAR WITH THE CEAL 4846 03:16:25,540 --> 03:16:26,341 PROGRAM, BUT IT'S REALLY 4847 03:16:26,407 --> 03:16:27,542 EXCITING TO SEE THE PROGRESS 4848 03:16:27,609 --> 03:16:30,278 THAT YOU'VE MADE IN JUST A FEW 4849 03:16:30,345 --> 03:16:30,478 YEARS. 4850 03:16:30,545 --> 03:16:32,480 SOMETHING THAT I KEEP THINKING 4851 03:16:32,547 --> 03:16:34,349 ABOUT THOUGH IS WITH THE TRUST 4852 03:16:34,415 --> 03:16:37,852 IN SCIENCE, I KNOW THIS IS DR. 4853 03:16:37,919 --> 03:16:41,222 BERTAGNOLLI'S FOCUS AS WELL, DID 4854 03:16:41,289 --> 03:16:45,059 COVID KIND OF HIGHLIGHT THIS 4855 03:16:45,126 --> 03:16:46,060 MISTRUST AND WE DIDN'T 4856 03:16:46,127 --> 03:16:49,464 UNDERSTAND IT EXISTED AS DEEPLY 4857 03:16:49,531 --> 03:16:50,632 AS IT DID? 4858 03:16:50,698 --> 03:16:53,301 OR WAS THERE A SHIFT THAT 4859 03:16:53,368 --> 03:16:53,668 HAPPENED? 4860 03:16:53,735 --> 03:16:55,136 OR DIGITAL SOCIAL MEDIA 4861 03:16:55,203 --> 03:16:55,570 HAPPENED? 4862 03:16:55,637 --> 03:16:57,338 I KNOW THE HEALTH EQUITY PIECE 4863 03:16:57,405 --> 03:16:58,873 AND GOING INTO THE COMMUNITIES 4864 03:16:58,940 --> 03:17:00,508 BUT IT'S JUST WE HEAR ABOUT IT 4865 03:17:00,575 --> 03:17:02,377 MORE THAN WE EVER HAD. 4866 03:17:02,443 --> 03:17:04,379 I'M INTERESTED TO KNOW WHAT WAS 4867 03:17:04,445 --> 03:17:05,780 HAPPENING BEFORE COVID IN TERMS 4868 03:17:05,847 --> 03:17:10,451 OF COMMUNITY OUTREACH AND TRUST 4869 03:17:10,518 --> 03:17:10,785 IN SCIENCE. 4870 03:17:10,852 --> 03:17:11,886 >> JENNIE THANK YOU. 4871 03:17:11,953 --> 03:17:13,555 A VERY IMPORTANT QUESTION. 4872 03:17:13,621 --> 03:17:15,390 THE SIMPLEST ANSWER IS YES. 4873 03:17:15,456 --> 03:17:18,693 IT'S REALLY ALL OF THE ABOVE. 4874 03:17:18,760 --> 03:17:21,629 THE TRUTH IS COVID DIDN'T CREATE 4875 03:17:21,696 --> 03:17:21,963 IT. 4876 03:17:22,030 --> 03:17:23,798 IT JUST LAID BARE WHAT WAS 4877 03:17:23,865 --> 03:17:26,901 AROUND FOR ALL OF US TO SEE. 4878 03:17:26,968 --> 03:17:29,103 IT'S VERY MUCH THE SAME AS 4879 03:17:29,170 --> 03:17:29,604 DISPARITIES. 4880 03:17:29,671 --> 03:17:31,940 YOU KNOW, COVID DIDN'T CREATE 4881 03:17:32,006 --> 03:17:33,374 THE DISPARITIES BUT RIGHT IN THE 4882 03:17:33,441 --> 03:17:37,111 FIRST FEW MONTHS OF COVID, YOU 4883 03:17:37,178 --> 03:17:38,846 RECALL THE DEATH RATE BETWEEN 4884 03:17:38,913 --> 03:17:41,516 AMERICAN INDIAN AND WHITE 4885 03:17:41,583 --> 03:17:42,684 POPULATION WAS ALMOST 45-FOLD. 4886 03:17:42,750 --> 03:17:46,521 WE SAID THIS IS COVID 4887 03:17:46,588 --> 03:17:48,022 DISPARITIES, BUT TRUTHFULLY 4888 03:17:48,089 --> 03:17:48,523 DISPARITIES EXISTED. 4889 03:17:48,590 --> 03:17:52,126 YOU'RE ABSOLUTELY RIGHT. 4890 03:17:52,193 --> 03:17:53,127 MISINFORMATION EXISTED. 4891 03:17:53,194 --> 03:17:57,265 BUT EVERYTHING ALMOST GOT A 4892 03:17:57,332 --> 03:18:00,902 BOOST, COMBINATION OF SOCIAL 4893 03:18:00,969 --> 03:18:04,372 MEDIA, COMBINATION OF MAYBE 4894 03:18:04,439 --> 03:18:08,009 SUBOPTIMAL REVIEW OF WHAT GOES 4895 03:18:08,076 --> 03:18:09,644 ON AND WHAT'S ALLOWED TO SHOW 4896 03:18:09,711 --> 03:18:10,845 BUT IN ESSENCE A LOT OF THINGS 4897 03:18:10,912 --> 03:18:14,015 WERE MAGNIFIED IN THE COVID ERA. 4898 03:18:14,082 --> 03:18:15,450 WE STILL HAVE MISINFORMATION 4899 03:18:15,516 --> 03:18:20,054 AROUND HIGH BLOOD PRESSURE. 4900 03:18:20,121 --> 03:18:21,022 FOR EVEN 20 YEARS AGO. 4901 03:18:21,089 --> 03:18:23,992 I RECALL WHEN I WAS TREATING 4902 03:18:24,058 --> 03:18:27,161 PATIENTS, THOUGH MANY PATIENTS 4903 03:18:27,228 --> 03:18:30,765 WHO WOULD NOT PAY FIVE DOLLARS 4904 03:18:30,832 --> 03:18:32,600 FOR HYDROCHLOROTHIAZIDE, PROVEN 4905 03:18:32,667 --> 03:18:35,903 IN NIH-FUNDED RESEARCH IN DOUBLE 4906 03:18:35,970 --> 03:18:36,771 BLIND PLACEBO-CONTROLLED TRIALS 4907 03:18:36,838 --> 03:18:39,507 THE LOWER BLOOD PRESSURE REDUCED 4908 03:18:39,574 --> 03:18:41,309 STROKE, REDUCED HEART FAILURE, 4909 03:18:41,376 --> 03:18:43,444 YET THEY PAID $30 FOR GARLIC 4910 03:18:43,511 --> 03:18:45,213 PILLS BECAUSE THEY DON'T WANT TO 4911 03:18:45,280 --> 03:18:46,414 TAKE MEDICINE AND THEY DON'T 4912 03:18:46,481 --> 03:18:47,949 TRUST HOW THE MEDICINES HAVE 4913 03:18:48,016 --> 03:18:48,716 BEEN DEVELOPED. 4914 03:18:48,783 --> 03:18:51,219 SO YOU'RE RIGHT, IT'S A VERY 4915 03:18:51,286 --> 03:18:53,755 IMPORTANT ISSUE, IT'S NOT NEW. 4916 03:18:53,821 --> 03:18:56,724 BUT THE COMBINATION OF SOCIAL 4917 03:18:56,791 --> 03:18:58,860 MEDIA, INSTANT ACCESS TO THE 4918 03:18:58,926 --> 03:18:59,961 NATION AND THE SPREAD. 4919 03:19:00,028 --> 03:19:01,829 THAT'S WHY WE HAVE TO APPROACH 4920 03:19:01,896 --> 03:19:03,931 WITH AS MUCH VIGOR AS IT IS IN 4921 03:19:03,998 --> 03:19:04,332 OUR COMMUNITY. 4922 03:19:04,399 --> 03:19:07,302 >> THANK YOU. 4923 03:19:07,368 --> 03:19:09,270 >> YES, THANK YOU, DR. MENSAH. 4924 03:19:09,337 --> 03:19:10,138 I'VE HAD THE PLEASURE OF SITTING 4925 03:19:10,204 --> 03:19:14,309 IN ON A FEW OF THE MEETINGS LED 4926 03:19:14,375 --> 03:19:19,447 BY PAUL JUAREZ HERE AT OUR 4927 03:19:19,514 --> 03:19:21,215 NEIGHBORING INSTITUTION AT 4928 03:19:21,282 --> 03:19:22,417 MEHARRY MEDICAL COLLEGE, VERY 4929 03:19:22,483 --> 03:19:24,152 FAMILIAR, INSPIRED BY THE WORK 4930 03:19:24,218 --> 03:19:25,386 OF CEAL. 4931 03:19:25,453 --> 03:19:26,554 I REALLY APPRECIATE THE 4932 03:19:26,621 --> 03:19:28,589 DISCUSSIONS WE HAD AND MATERIALS 4933 03:19:28,656 --> 03:19:30,725 THAT REALLY FOCUSED ON MAKING 4934 03:19:30,792 --> 03:19:33,361 SURE THAT THEY WERE INCLUSIVE, 4935 03:19:33,428 --> 03:19:35,330 DIVERSE BY AGE AND ALSO 4936 03:19:35,396 --> 03:19:37,465 ETHNICITY AND ANCESTRY. 4937 03:19:37,532 --> 03:19:39,167 I WAS WONDERING, I HAVE TONS OF 4938 03:19:39,233 --> 03:19:42,136 QUESTIONS THAT WE DON'T HAVE 4939 03:19:42,203 --> 03:19:45,073 ENOUGH TIME FOR, BUT I DID FOCUS 4940 03:19:45,139 --> 03:19:46,174 REALLY LOOKING AT THE NLM 4941 03:19:46,240 --> 03:19:48,576 STRATEGIC PLAN, SOME THINGS YOU 4942 03:19:48,643 --> 03:19:49,677 MENTIONED HERE, IS THERE 4943 03:19:49,744 --> 03:19:52,080 OPPORTUNITY FOR CEAL TO BE USED 4944 03:19:52,146 --> 03:19:54,615 AS THAT KIND OF WORKFORCE 4945 03:19:54,682 --> 03:19:55,917 DEVELOPMENT, WITH THE SHORTAGES 4946 03:19:55,983 --> 03:19:58,319 OF PUBLIC HEALTH WORKFORCE THAT 4947 03:19:58,386 --> 03:20:00,088 WE'VE BEEN HEARING ABOUT, OVER 4948 03:20:00,154 --> 03:20:02,256 THE LAST FEW YEARS, BUT ARE 4949 03:20:02,323 --> 03:20:03,691 THERE OPPORTUNITIES THAT YOU ALL 4950 03:20:03,758 --> 03:20:06,027 SEE AT HIGHER LEVEL THAT CAN 4951 03:20:06,094 --> 03:20:08,496 START TO LOOK AT PROGRAMMING FOR 4952 03:20:08,563 --> 03:20:11,332 TRYING TO GET EVEN AS LOW AS 4953 03:20:11,399 --> 03:20:12,867 HIGH SCHOOLS TO START 4954 03:20:12,934 --> 03:20:13,868 UNDERSTANDING ABOUT COMMUNITY 4955 03:20:13,935 --> 03:20:17,572 RESEARCH AND PUBLIC HEALTH 4956 03:20:17,638 --> 03:20:19,874 RESEARCH, EVEN BIOMEDICAL 4957 03:20:19,941 --> 03:20:20,742 RESEARCH? 4958 03:20:20,808 --> 03:20:22,844 >> ABSOLUTELY IMPORTANT. 4959 03:20:22,910 --> 03:20:23,277 THANKS. 4960 03:20:23,344 --> 03:20:25,913 I'M NOT SURE, I SEE PHILIP 4961 03:20:25,980 --> 03:20:26,681 WALKER, PLEASE FORGIVE ME, I 4962 03:20:26,748 --> 03:20:29,083 DON'T KNOW WHAT TITLE YOU USE, I 4963 03:20:29,150 --> 03:20:32,353 REALLY APPRECIATE YOUR ASKING 4964 03:20:32,420 --> 03:20:33,554 THAT QUESTION. 4965 03:20:33,621 --> 03:20:35,423 IT'S REALLY IMPORTANT, EVEN 4966 03:20:35,490 --> 03:20:37,625 THOUGH WE ARE WELL NOPE FOR 4967 03:20:37,692 --> 03:20:38,493 CONDUCTING RESEARCH, THERE'S 4968 03:20:38,559 --> 03:20:40,895 ANOTHER IMPORTANT ASPECT OF OUR 4969 03:20:40,962 --> 03:20:42,196 WORK WHICH IS WORKFORCE 4970 03:20:42,263 --> 03:20:43,631 DEVELOPMENT, TRAINING AND CAREER 4971 03:20:43,698 --> 03:20:43,931 DEVELOPMENT. 4972 03:20:43,998 --> 03:20:46,968 AND NOT JUST TRAINING AND CAREER 4973 03:20:47,034 --> 03:20:50,238 DEVELOPMENT, LATE STAGES OF 4974 03:20:50,304 --> 03:20:51,305 RESEARCH, STRONG INTEREST IN 4975 03:20:51,372 --> 03:20:52,073 EARLY-STAGE INVESTIGATORS, ALL 4976 03:20:52,140 --> 03:20:56,677 THE WAY DOWN TO HIGH SCHOOL AND 4977 03:20:56,744 --> 03:20:57,245 BEYOND. 4978 03:20:57,311 --> 03:20:58,646 SOME PEOPLE BELIEVING WE SHOULD 4979 03:20:58,713 --> 03:20:59,313 START SOONER. 4980 03:20:59,380 --> 03:21:03,785 THE RESPONSE TO YOUR QUESTION IS 4981 03:21:03,851 --> 03:21:05,653 YES, BY TAKING THE FRAMEWORK AND 4982 03:21:05,720 --> 03:21:09,590 SAYING EVEN THOUGH WE'RE IN THE 4983 03:21:09,657 --> 03:21:10,458 COMMUNITIES, WHAT CAN THE 4984 03:21:10,525 --> 03:21:12,560 COMMUNITIES DO IN RESEARCH, WE 4985 03:21:12,627 --> 03:21:14,729 CAN PLAY A CRUCIAL ROLE IN 4986 03:21:14,796 --> 03:21:15,696 COMMUNITY CAPACITY BUILDING 4987 03:21:15,763 --> 03:21:19,233 WHETHER THROUGH COMMUNITY HEALTH 4988 03:21:19,300 --> 03:21:23,471 WORKERS, COMMUNITY NURSES, 4989 03:21:23,538 --> 03:21:24,338 SOCIAL SCIENCE, SOCIAL WORKERS, 4990 03:21:24,405 --> 03:21:26,441 ALL COMES UNDER OUR MISSION OF 4991 03:21:26,507 --> 03:21:28,075 RESEARCH TRAINING AND CAREER 4992 03:21:28,142 --> 03:21:29,277 DEVELOPMENT, AND I THINK THE 4993 03:21:29,343 --> 03:21:31,779 CEAL PLATFORM IS NOT THE ONLY 4994 03:21:31,846 --> 03:21:35,416 ONE BUT AT LEAST IN RECENT TIMES 4995 03:21:35,483 --> 03:21:36,818 WE BELIEVE IT'S ONE OF THE FEW 4996 03:21:36,884 --> 03:21:38,886 THAT PAYS ATTENTION TO WHAT THE 4997 03:21:38,953 --> 03:21:46,427 COMMUNITY MMUNITY WANTS, WHAT 4998 03:21:46,494 --> 03:21:47,762 THE COMMUNITY NEEDS, AS OPPOSED 4999 03:21:47,829 --> 03:21:49,397 TO WE'RE DOING OUR WORK, COMING 5000 03:21:49,464 --> 03:21:51,199 INTO THE COMMUNITY, FIVE 5001 03:21:51,265 --> 03:21:52,800 PRIORITIES, WE'D LIKE YOU TO 5002 03:21:52,867 --> 03:21:53,568 JOIN OUR RESEARCH. 5003 03:21:53,634 --> 03:21:55,436 WE'RE TURNING THINGS AROUND. 5004 03:21:55,503 --> 03:21:56,838 THANK YOU FOR MENTIONING IT. 5005 03:21:56,904 --> 03:21:58,139 IT'S REALLY IMPORTANT. 5006 03:21:58,206 --> 03:22:00,775 NLM WORKING WITH US, WORKING 5007 03:22:00,842 --> 03:22:03,411 WITH ALL OF US, WITH COMPASS, 5008 03:22:03,478 --> 03:22:06,781 ALL OF THESE PROGRAMS HAVE THE 5009 03:22:06,848 --> 03:22:08,316 UNIQUE OPPORTUNITY TO REALLY 5010 03:22:08,382 --> 03:22:12,920 MAKE A DIFFERENCE AND GO BEYOND 5011 03:22:12,987 --> 03:22:17,191 WHAT WE HAVEN'T TRADITIONALLY 5012 03:22:17,258 --> 03:22:19,160 BEEN DOING. 5013 03:22:19,227 --> 03:22:20,027 DR. AZAR? 5014 03:22:20,094 --> 03:22:21,896 >> DR. MENSAH, FANTASTIC TALK. 5015 03:22:21,963 --> 03:22:23,531 I REALLY APPRECIATE IT. 5016 03:22:23,598 --> 03:22:26,267 I GUESS THE QUESTION I HAVE IS 5017 03:22:26,334 --> 03:22:31,506 WHAT DO YOU DO ABOUT ALGORITHMIC 5018 03:22:31,572 --> 03:22:33,574 DISINFORMATION, WHERE, YOU KNOW, 5019 03:22:33,641 --> 03:22:35,710 SOME MEDIA COMPANIES ARE 5020 03:22:35,776 --> 03:22:37,512 AMPLIFYING SALACIOUS THINGS THAT 5021 03:22:37,578 --> 03:22:40,381 ARE I MEAN PROVEN TO BE FALSE, 5022 03:22:40,448 --> 03:22:43,985 BUT THAT'S WHERE, YOU KNOW, THE 5023 03:22:44,051 --> 03:22:45,987 DISCOURSE GOES, NOT NECESSARILY 5024 03:22:46,053 --> 03:22:48,723 TOWARDS PEER REVIEWED NIH 5025 03:22:48,789 --> 03:22:50,124 STUDIES, RIGHT? 5026 03:22:50,191 --> 03:22:52,226 SO JUST A QUESTION. 5027 03:22:52,293 --> 03:22:52,660 OVER. 5028 03:22:52,727 --> 03:22:53,861 >> A VERY IMPORTANT QUESTION. 5029 03:22:53,928 --> 03:22:57,598 IN FACT, THAT WAS THE REASON WHY 5030 03:22:57,665 --> 03:23:01,235 WE SUPPORTED A PILOT TO SEE IF 5031 03:23:01,302 --> 03:23:05,139 I-HEARD ST. LOUIS COULD BE 5032 03:23:05,206 --> 03:23:07,008 SCALED AND SPREAD. 5033 03:23:07,074 --> 03:23:08,976 YOU KNOW WE'RE NOT A REGULATORY 5034 03:23:09,043 --> 03:23:12,046 AGENCY SO WE HAVE VERY LITTLE 5035 03:23:12,113 --> 03:23:13,147 INFLUENCE ON REGULATIONS, THAT 5036 03:23:13,214 --> 03:23:14,782 CAN HAVE AN IMPACT. 5037 03:23:14,849 --> 03:23:17,718 WE VERY OFTEN DO NOT DEVELOP 5038 03:23:17,785 --> 03:23:19,487 POLICY, WE CAN INFORM POLICY AND 5039 03:23:19,554 --> 03:23:22,623 PROVIDE EVIDENCE THAT WOULD LEAD 5040 03:23:22,690 --> 03:23:26,127 TO INFORMING POLICY, AND WE'RE 5041 03:23:26,193 --> 03:23:29,430 HOPING RESEARCH WILL DO HOW YOU 5042 03:23:29,497 --> 03:23:30,064 SPREAD SCIENCE-BASED INFORMATION 5043 03:23:30,131 --> 03:23:34,235 AND GET PICKED UP AND GROW LIKE 5044 03:23:34,302 --> 03:23:34,535 WILDFIRE. 5045 03:23:34,602 --> 03:23:36,637 JUST IMAGINE IN EVERY COMMUNITY 5046 03:23:36,704 --> 03:23:38,806 WE HAVE WHEN EVER THERE'S 5047 03:23:38,873 --> 03:23:40,341 MISINFORMATION THEY HAVE ACCESS 5048 03:23:40,408 --> 03:23:42,209 TO TRUSTED INFORMATION. 5049 03:23:42,276 --> 03:23:43,844 I HAVE FAMILY MEMBERS WHO WILL 5050 03:23:43,911 --> 03:23:46,514 NOT CALL ME, GO ON THE WEB 5051 03:23:46,581 --> 03:23:48,349 FIRST, AND THEN SEVERAL WEEKS 5052 03:23:48,416 --> 03:23:49,483 LATER, WELL, YOU KNOW, I DIDN'T 5053 03:23:49,550 --> 03:23:50,217 WANT TO BROTHER YOU. 5054 03:23:50,284 --> 03:23:52,653 THIS IS WHY THE WEB WAS SAYING 5055 03:23:52,720 --> 03:23:56,791 WE REALLY NEED TO CHANGE THAT. 5056 03:23:56,857 --> 03:23:59,260 AND FOR ME, I'M EXCITED ABOUT 5057 03:23:59,327 --> 03:24:00,528 THE NATIONAL LIBRARY OF 5058 03:24:00,595 --> 03:24:02,263 MEDICINE, YOU DEAL WITH TRUST. 5059 03:24:02,330 --> 03:24:06,434 THERE'S SO MUCH TRUST THERE THAT 5060 03:24:06,500 --> 03:24:07,868 WHAT YOU DO, VERY STRONG 5061 03:24:07,935 --> 03:24:09,370 OPPORTUNITY TO BE SCALED. 5062 03:24:09,437 --> 03:24:13,441 THAT'S WHY WE'RE HOPING WE HAVE 5063 03:24:13,507 --> 03:24:15,910 OPPORTUNITY TO WORK TOGETHER. 5064 03:24:15,977 --> 03:24:20,047 >> THANK YOU. 5065 03:24:20,114 --> 03:24:21,649 >> HI, MARY. 5066 03:24:21,716 --> 03:24:22,516 GO AHEAD. 5067 03:24:22,583 --> 03:24:23,417 >> HI. 5068 03:24:23,484 --> 03:24:24,919 WELL, FIRST OF ALL, DR. MENSAH, 5069 03:24:24,986 --> 03:24:27,221 THANK YOU FOR A TERRIFIC 5070 03:24:27,288 --> 03:24:29,991 PRESENTATION. 5071 03:24:30,057 --> 03:24:33,461 THIS IS REALLY EXCITING. 5072 03:24:33,527 --> 03:24:36,330 A REALLY EXCITING EFFORT. 5073 03:24:36,397 --> 03:24:39,834 MY QUESTION IS, HAVE YOU NOTICED 5074 03:24:39,900 --> 03:24:42,570 A CHANGE IN BEHAVIOR, WITH THE 5075 03:24:42,637 --> 03:24:44,672 PILOTS, WITH GETTING MORE 5076 03:24:44,739 --> 03:24:45,272 SCIENCE-BASED INFORMATION OUT 5077 03:24:45,339 --> 03:24:48,376 THERE, HAVE YOU BEEN ABLE TO 5078 03:24:48,442 --> 03:24:49,243 MEASURE A CHANGE? 5079 03:24:49,310 --> 03:24:50,878 AND FOR EXAMPLE, WITH COVID, 5080 03:24:50,945 --> 03:24:55,483 ONCE YOU STARTED TO PUSH OUT, 5081 03:24:55,549 --> 03:24:57,018 CORRECT INFORMATION, AND 5082 03:24:57,084 --> 03:24:58,953 CHALLENGE FALSE INFORMATION 5083 03:24:59,020 --> 03:25:02,189 THAT'S OUT THERE, DID YOU SEE AN 5084 03:25:02,256 --> 03:25:06,427 UPTAKE IN THE VACCINE AND WERE 5085 03:25:06,494 --> 03:25:09,964 SOME OTHER AREAS THAT YOU'RE 5086 03:25:10,031 --> 03:25:11,365 MOVING INTO, I WOULD ASSUME HAVE 5087 03:25:11,432 --> 03:25:13,768 YOU SOME PLAN TO MEASURE 5088 03:25:13,834 --> 03:25:16,504 OUTCOMES OF GETTING MORE 5089 03:25:16,570 --> 03:25:17,505 INFORMATION OUT THERE. 5090 03:25:17,571 --> 03:25:21,208 >> THANK YOU VERY MUCH. 5091 03:25:21,275 --> 03:25:21,976 EXTREMELY IMPORTANT QUESTION. 5092 03:25:22,043 --> 03:25:28,215 IN THE EARLY DAYS OF THE 5093 03:25:28,282 --> 03:25:29,316 PANDEMIC HOW FOCUS WAS ON 5094 03:25:29,383 --> 03:25:33,954 GETTING PEOPLE TO SIGN UP. 5095 03:25:34,021 --> 03:25:35,823 WE DIDN'T HAVE A RIGOROUS WAY TO 5096 03:25:35,890 --> 03:25:37,224 MEASURE IMPACT OTHER THAN LOOK 5097 03:25:37,291 --> 03:25:39,560 AT NATIONAL SURVEY. 5098 03:25:39,627 --> 03:25:40,094 THERE'S GOOD NEWS. 5099 03:25:40,161 --> 03:25:50,638 IF YOU LOOK AT MISSISSIPPI, 5100 03:25:59,814 --> 03:26:01,782 AROUND JULY OF 2021, TO MAKE A 5101 03:26:01,849 --> 03:26:06,087 LONG STORY SHORT WE WERE 5102 03:26:06,153 --> 03:26:09,523 THRILLED BY THE END OF 2021 OR 5103 03:26:09,590 --> 03:26:11,525 BEGINNING OF 2022, VACCINE 5104 03:26:11,592 --> 03:26:12,893 HESITANCY RATE IN BLACKS AND 5105 03:26:12,960 --> 03:26:15,329 WHITES WERE ABOUT THE SAME. 5106 03:26:15,396 --> 03:26:18,299 IN FACT, WILLINGNESS TO ACCEPT 5107 03:26:18,365 --> 03:26:19,600 WAS HIGHER IN AFRICAN AMERICANS 5108 03:26:19,667 --> 03:26:20,935 THAN IN WHITES. 5109 03:26:21,001 --> 03:26:23,871 OF COURSE, WE'RE WANTED IT TO BE 5110 03:26:23,938 --> 03:26:26,273 HIGH IN EVERYONE BUT IN ONE 5111 03:26:26,340 --> 03:26:30,444 COMMUNITY THAT HAD SUCH 5112 03:26:30,511 --> 03:26:34,582 DISTRUST, THE FACT THE VACCINE 5113 03:26:34,648 --> 03:26:36,250 WAS DEVELOPED SO QUICKLY, HOW 5114 03:26:36,317 --> 03:26:38,753 CAN YOU TRUST THAT, DID YOU CUT 5115 03:26:38,819 --> 03:26:39,487 CORNERS? 5116 03:26:39,553 --> 03:26:40,421 THERE'S VERY GOOD EVIDENCE IT 5117 03:26:40,488 --> 03:26:42,056 DID MAKE A DIFFERENCE. 5118 03:26:42,123 --> 03:26:44,658 WE HAVE SIMILAR DATA FROM 5119 03:26:44,725 --> 03:26:47,962 LOUISIANA, WHERE, AGAIN, THE GAP 5120 03:26:48,028 --> 03:26:49,797 BETWEEN ACCEPTANCE RATE IN 5121 03:26:49,864 --> 03:26:50,898 AFRICAN AMERICANS AND WHITE 5122 03:26:50,965 --> 03:26:51,265 CLOSED. 5123 03:26:51,332 --> 03:26:54,835 UNFORTUNATELY WE DON'T HAVE VERY 5124 03:26:54,902 --> 03:26:58,773 OBJECTIVE DATA YET IN AMERICAN 5125 03:26:58,839 --> 03:26:59,874 INDIAN AND ALASKA NATIVE, BUT 5126 03:26:59,940 --> 03:27:09,083 SOME DATA SUGGESTS IT CAN MAKE 5127 03:27:09,150 --> 03:27:10,050 A DIFFERENCE. 5128 03:27:10,117 --> 03:27:11,819 WE COMPLETE THE PILOT IN 5129 03:27:11,886 --> 03:27:12,520 SEPTEMBER AND HAVE OBJECTIVE 5130 03:27:12,586 --> 03:27:20,461 DATA WE CAN SHARE WITH YOU. 5131 03:27:20,528 --> 03:27:21,562 >> THANK YOU. 5132 03:27:21,629 --> 03:27:22,997 AGAIN, IT'S BEEN WONDERFUL TO 5133 03:27:23,063 --> 03:27:25,633 WELCOME YOU TO PRESENT TODAY. 5134 03:27:25,699 --> 03:27:29,436 AND I THINK THIS IS AN AREA 5135 03:27:29,503 --> 03:27:39,747 WHERE THERE WILL BE DISCUSSIO 5136 03:27:39,814 --> 03:27:45,319 AND OPPORTUNITY FOR 5137 03:27:45,386 --> 03:27:45,786 COLLABORATION. 5138 03:27:45,853 --> 03:27:53,127 >> NEXT ON THE LIST IS 5139 03:27:53,194 --> 03:27:57,631 APPOINTMENT OF THE NOMINATING 5140 03:27:57,698 --> 03:28:02,203 COMMITTEE, DELIGHTED TO SHARE 5141 03:28:02,269 --> 03:28:03,204 THAT LAUREN MATTHEW, MARY 5142 03:28:03,270 --> 03:28:04,405 MAZANEK AND PAUL WESTER AGREED 5143 03:28:04,471 --> 03:28:08,242 TO SERVE ON THE NOMINATING 5144 03:28:08,309 --> 03:28:09,109 COMMITTEE, WORKING WITH AN 5145 03:28:09,176 --> 03:28:10,878 UPDATE IN THE FUTURE MEETINGS. 5146 03:28:10,945 --> 03:28:12,947 SO THANK YOU ALL VERY MUCH FOR 5147 03:28:13,013 --> 03:28:14,515 THAT. 5148 03:28:14,582 --> 03:28:17,017 WE APPRECIATE YOUR SERVICE. 5149 03:28:17,084 --> 03:28:19,620 AND WITH THAT, WE CAN CONCLUDE 5150 03:28:19,687 --> 03:28:21,488 THE OPEN PORTION OF THE BOARD OF 5151 03:28:21,555 --> 03:28:23,657 REGENTS MEETING. 5152 03:28:23,724 --> 03:28:25,659 WE WILL BE GOING INTO CLOSED 5153 03:28:25,726 --> 03:28:26,961 SESSION NOW, BUT I'D LIKE TO 5154 03:28:27,027 --> 03:28:28,596 THANK EVERYONE WHO WAS ABLE TO 5155 03:28:28,662 --> 03:28:31,966 JOIN US TODAY AND WE LOOK 5156 03:28:32,032 --> 03:28:32,967 FORWARD TO ONGOING CONVERSATIONS 5157 03:28:33,033 --> 03:28:35,870 ABOUT ALL OF THESE IMPORTANT 5158 03:28:35,936 --> 03:28:36,337 TOPICS COVERED. 5159 03:28:36,403 THANK YOU.