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>>WELCOME

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EVERYONE TO THE 216TH COUNCIL

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MEETING FOR NINDS. MOST OF OUR

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COUNCIL MEMBERS ARE PRESENT, I

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THINK CLAUDIA HAS A CONFLICT,

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MIGHT POP IN LATER. CLAUDIA

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LUCHINETTI, BOB BROWN WILL JOIN

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US IN A COUPLE OF HOURS TODAY

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LATER. AND EVERYONE ELSE SHOULD

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BE HERE. HOPE EVERYONE IS DOING

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WELL. BOB BROWN IS AN AD HOC

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LAST TIME BUT NOW OFFICIALLY

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APPOINTED AND PROBABLY PEOPLE

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KNOW HE'S THE DIRECTOR OF THE

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PROGRAM NEUROTHERAPEUTICS AT

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UMASS. WE ARE LOOKING FORWARD TO

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THIS NOW COMPLETELY COMPOSED

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COUNCIL GROUP. IT IS COUPLE OF

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HIGHLIGHTS IN TERMS OF PEOPLE

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WHO HAVE BEEN MOVED INTO EVEN

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HIGHER UP LEADERSHIP POSITIONS

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AT NINDS, CHRISTINE LAMB WAS

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PROMOTED TO OFFICE CHIEF BUDGET

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OFFICER, AND JEW DI CHIEF

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INFORMATION OFFICER. THOSE TWO

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PEOPLE ARE INC ABLY IMPORTANT TO

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THE INSTITUTE AND CERTAINLY JUDY

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EVEN MORE SO SINCE COVID. SO

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THANKS TO JUDY AND CHRISTINE FOR

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TAKING THESE OVER. WE HAVE A

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GREAT MEETING LINED UP AND I

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WILL HAND IT TO BOB NOW.

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>> THANKS A LOT, WALTER.

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WELCOME, EVERYBODY. I SEE ANNA

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-- AARON AND -- HAVE NOW JOINED

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US. SO WE HAVE EVERYONE BESIDES

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THE TWO WALTER MENTIONEDED.

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WELCOME TO OPEN SESSION. GREAT

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TO SEE YOU. MAYBE SOME DAY SOON

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IN PERSON, WHO KNOWS. I WILL

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START WITH MY USUAL REMINDER

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THAT THESE EXCITING MEETINGS ARE

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VIDEOCAST LIVE AND ARCHIVED.

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THERE IS ALLAN. GREAT. SO BE ON

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YOUR BEST BEHAVIOR AND TRY TO

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LOOK YOUR BEST, SPRUCE UP U YOU

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CAN DO THAT. /WON'T GO INTO THE

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USUALS EXPLANATION OF ZOOM

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RULES, I THINK EVERYBODY KNOWS

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BY NOW. THE ONLY REMINDER IS

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THAT IF YOU WANT TO SAY

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SOMETHING OR MAKE A MOTION OR

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WHATEVER, EITHER JUST SPEAK UP

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OR RAISE YOUR HAND, YOU CAN

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RAISE YOUR ACTUAL HAND AND WAVE

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IT IN FRONT OF ME FACE, I WILL

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SEE IT. AND THE VOTING AS USUAL

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WILL BE DONE BY THE CHAT, TIM

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WHO IS TAKING OVER AS OUR NEW

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COUNCIL POINT PERSON WILL PUT

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THE MOTION IN THE CHAT.  AND

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THEN YOU CAN ALL VOTE.  SPEAKING

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OF KELLY, KELLY HAS COVID AND

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SHE -- WHICH IS REALLY

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UNFORTUNATE.  THIS WAS LIKE MY

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NIGHTMARE THAT BEFORE COUNCIL

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SOMETHING WOULD HAPPEN TO KELLY.

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THE NIGHTMARE OCCURRED THOUGH

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SHE IS FEELING BETTER BUT YOU

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WON'T SEE HER ON THE VIDEO OR

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HEAR HER. SHE IS WORKING IN THE

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BACKGROUND TO MAKE THINGS

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BETTER. SHE REFUSES TO GO TO BED

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WHICH IS PROBABLY WHERE SHE

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BELONGS. TIM AND BROOK ARE DOING

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GREAT JOB SUBSTITUTING FOR KELLY

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AND DOING THEIR PART. SO UNLESS

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THERE IS ANY QUESTIONS I'M GOING

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TO GO INTO MY USUAL BOILERPLATE

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INTRODUCTION WHICH IS THAT WE

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NEED YOUR APPROVAL OF THE

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MINUTES FROM OUR LAST MEETING

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WHICH WERE IN THE ELECTRONIC

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COUNCIL BOOK FIRST POSTING

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SECTION NINDS GENERAL

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INFORMATION TAB. UNLESS YOU WANT

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TO DISCUSS THE MINUTES I NEED A

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MOTION. SO I SEE A MOTION FROM

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LOUISE AND SECOND FROM TIM.

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EVERYBODY, TIM HAS JUST ENTERED

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THE MOTION INTO THE CHAT SO

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EVERYBODY VOTE. THIS IS A TEST

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OF OUR ABILITY TO MAKE A MOMENT

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AND VOTE ON IT. LOOKS LIKE WE

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PASSED. ALSO UNDER THIS NINDS

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GENERAL INFORMATION TAB ECB

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THERE IS A LISTING OF ALL

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COUNCIL MEETINGS, THROUGH 2024.

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THESE MEETINGS WILL CONTINUE TO

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TAKE PLACE ON WEDNESDAY AND

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THURSDAY THOUGH IF WE GO TO IN

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PERSON AND WALTER WILL TALK

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ABOUT THAT, OBVIOUSLY TIMES

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MIGHT CHANGE, ONE THROUGH FIVE

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OR ONE THROUGH SIX SO HOLD THESE

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DATES IN YOUR CALENDAR AND LET

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TIM OR KELLY OR RICK KNOW IF YOU

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HAVE A PROBLEM WITH ANY OF THEM 

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MOVING RIGHT ALONG, WE HAVE I'M

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REQUIRED TO TELL YOU ABOUT

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EXPEDITED REVIEW PROCESS. THIS

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IS JUST THE PROCESS IN WHICH

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THREE DESIGNATED COUNCIL

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MEMBERS, CLAUDIA TOM AND I

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BELIEVE SAMEER, DESIGNATED THIS

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YEAR. THESE THREE COUNCIL

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MEMBERS APPROVE SUBSET OF

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APPLICATIONS FOR FUNDING BEFORE

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COUNCIL MEETS. THIS ALLOWS

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GRANTS MANAGEMENT BRANCH TO GET

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AWARDS OUT THE DOORS EVEN BEFORE

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COUNCIL OCCURS OR JUST AFTER.

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TYPICALLY FOCUSES ON RO1 AND

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GRANTS WITH SCORES WITHIN PAY

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LINE WITH NO ISSUES THAT REQUIRE

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ANY COUNCIL DISCUSSION. SO

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THANKS TO CLAUDIA, TOM AND

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SAMEER. THERE WERE 150

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APPLICATIONS EXPEDITED AND A LOT

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WERE ALREADY OUT THE DOOR, I SAY

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THIS EVERY SINGLE ROUND BECAUSE

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IT IS IMPORTANT WHICH IS THAT

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THIS IS A TESTAMENT TO HOW GOOD

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OUR GRANTS MANAGEMENT STAFF ARE.

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THESE ARE PEOPLE BEHIND THE

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SCENES WHO ISSUE THE AWARDS. AND

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THE GRANTS MANAGEMENT BRANCH IS

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LED BY SHELLEY WILLBORN WHO

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JOINED RECENTLY AND A TESTAMENT

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TO OUR PROGRAM SATISFY WHO ARE

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ABLE TO ENTER ALL THE

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INFORMATION T AT GRANTS

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MANAGEMENT NEEDS TO ENTER THE

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AWARDS. SO EVERYBODY CONTINUE

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DOING THIS DURING COVID AND IF

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ANYTHING WE GOT MORE EFFICIENT

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IN THIS PROCESS. SO THAT IS

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GREAT. WE USED TO -- I'M TALKING

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QUICKLY BECAUSE WE HAVE A LOT ON

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THE AGENDA. WE USED TO

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INDIVIDUALLY INTRODUCE ALL THE

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NEW STAFF WHO ARE JOINING NINDS.

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CAN SOMEBODY PUT THE LIST OF NEW

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STAFF UP? JOHN IF JASMINE DOES

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THAT OR BROOK. WHILE THEY ARE

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DOING THAT, IN THE INTEREST OF

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STREAMLINING THESE VIRTUAL

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MEETINGS, WE DON'T INTRODUCE

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EVERYBODY BUT ENCOURAGE YOU TO

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LOOK AT THE BIOs OF ALL THESE

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EXTREMELY INTERESTING PEOPLE IN

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THE E C,B. VERY INTERESTING AND

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IMPRESS SHIV BACKGROUNDS.  THE

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ONLY TWO THAT -- WALTER WHEN HE

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SPEAKS IS GOING TO I THINK

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INTRODUCE OUR NEW BUDGET OFFICER

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AND AS WELL AS SOMEONE WHO I SEE

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IS NOT -- THERE SHE IS, JUDY OUR

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NEW CIO CHIEF INFORMATION

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OFFICER, HE WILL BE TALKING

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ABOUT THAT. THE ONLY PERSON THAT

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I WILL TALK ABOUT IN DETAIL IS

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ANNA TAYLOR, YOU CAN SEE HER ON

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THE DIVISION OF EXTRAMURAL

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ACTIVITIES.  SHE IN A HIGH

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LEADERSHIP POSITION NOW AND

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INTERACTING SIGNIFICANTLY WITH

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YOU IN THESE COUNCIL MEETINGS.

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SO THE NEW POSITION ANNA TAYLOR

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SPOKEN A NUMBER OF TIMES COUNCIL

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PROMOTED TO IS CALLED DIRECTOR

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OF RESEARCH OPERATIONS AND

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ANALYSIS. SO ANNA FOR MANY YEARS

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HAS LED VERY IMPORTANT

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INITIATIVES AND ANALYSES FOR

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EXAMPLE SHE SPEARHEADED THAT NIH

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NEUROBIOBANK WHICH IS A VERY

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IMPORTANT INITIATIVE AND SHE LED

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OUR ANALYSIS THAT WAS PREVENTED

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AT COUNCIL MULTIPLE TIMES TRENDS

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AND FUNDING OF BASIC AND APPLIED

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RESEARCH. THIS IS A BIG DEAL AT

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THE TIME AND SOME OF YOU MIGHT

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HAVE HEARD OF IT. IN ANY CASE,

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SHE HAS ALWAYS PLAYED AD REALLY

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IMPORTANT ROLE IN GETTING THE

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DIFFERENT PARTS OF EXTRAMURAL TO

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WORK TOGETHER AS EFFECTIVELY AS

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POSSIBLE. GRANTS MANAGEMENT

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PROGRAM, BUDGET OFFICE, ET

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CETERA.  O IN HER NEW POSITION

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SHE WILL OVERSEE ADMINISTRATIVE

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BRANCH LED BY KELLY BAKER OUR

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GRANTS MANAGEMENT GROUP AND NEW

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BRAND -- OFFICES OR RATHER

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BRANCHES OF ANALYSIS AND

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RESEARCH OPERATIONS WHICH WILL

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BE -- YOU WILL BE HEARING MORE

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ABOUT LATER SO THIS IS A

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CRITICAL POSITION AND BY THE WAY

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ONE OF ITS GOALS IS TO GET

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GRANTS OUT THE DOOR MORE

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EFFICIENTLY AND MORE QUICKLY,

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WHICH IS DEFINITELY IN THE

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INTEREST OF EXTRAMURAL

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SCIENTIFIC COMMUNITY AND ALSO IN

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THE INTEREST OF OUR STAFF MAKING

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THINGS EASIER. SO WELCOME, ANNA,

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TO OUR NEW POSITION. WALTER

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ANNOUNCED CHRISTINE AND JUDY'S

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NEW POSITION, SORRY YOU HAVE I

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WAS READING MY NOTES SO LOOKS

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LIKE WE ARE DONE WITH

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INTRODUCTIONS. BUT AT THIS POINT

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I WILL JUST TURN THINGS OVER TO

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WALTER FOR HIS DIRECTOR'S TAL T.

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>> OKAY. JASMINE, IF YOU
COULD

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-- IF YOU CAN HIT THE BUTTON, WE

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PRE-RECORDED THE MESSAGE. TRY TO

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BE MORE TIME EFFICIENT.

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>> IT IS MY PLEASURE TO
GIVE THE

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NINDS DIRECTORS REPORT FOR THIS

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216TH MEETING OF THE NINDS

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COUNCIL. I WANT TO START BY

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TALKING IN GENERAL

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>> WAS ACTING DIRECTOR OF
THE

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FDA FOR A WHILE WHILE HE WAS

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ALSO HERE AT NIH. THE PRINCIPLE

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DEPUTY DIRECTOR DR. DOUG LOWY,

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NCI ACTING DIRECTOR, POSITION HE

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HAD MULTIPLE TIMES IN THE PAST

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AND GREAT AT IT.  AS PEOPLE MAY

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KNOW THERE IS A SEARCH FOR NEW

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DIRECTOR ONGOING AND I THINK

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THEY HAVE CANDIDATES BUT WE

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DON'T REALLY KNOW, WE MAY BE THE

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LAST TO KNOW WHO THE FINAL

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CHOICE IS. LOOKING FORWARD TO

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WORKING WITH A NEW DIRECTOR

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GOING FORWARD AS WE HAVE WITH

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DR. COLLINS AND NOW DR. TABAK,

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ACTING DIRECTOR. WE WERE ABLE TO

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GET A BUDGET THIS YEAR THANK

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GOODNESS AND WE TALKED IN THE

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PAST THAT GOING WITH CONTINUOUS

256
00:10:40,960 --> 00:10:42,400
CR THROUGHOUT THE YEAR CREATED

257
00:10:42,400 --> 00:10:44,120
PROBLEMS FOR BUDGET BUT DID GET

258
00:10:44,120 --> 00:10:48,000
BUDGET INCREASE, IN MARCH, YOU

259
00:10:48,000 --> 00:10:50,880
CAN SEE HERE THE BASE BUDGET OF

260
00:10:50,880 --> 00:10:56,400
THE INSTITUTE WHEN UP SLIGHTLY,

261
00:10:56,400 --> 00:11:01,200
TO $2,082,000,000, 3.3% CHANGE,

262
00:11:01,200 --> 00:11:04,560
PRETTY MUCH IN LINE WITH THE

263
00:11:04,560 --> 00:11:05,600
OTHER INSTITUTES. HOWEVER WE DID

264
00:11:05,600 --> 00:11:08,600
GET FUNDS FROM THE BRAIN

265
00:11:08,600 --> 00:11:10,680
INITIATIVE. SOME WHICH COMES

266
00:11:10,680 --> 00:11:12,560
FROM THE CURES ACT AND ALSO

267
00:11:12,560 --> 00:11:15,240
MONEY FOR THE HEAL INITIATIVE

268
00:11:15,240 --> 00:11:18,120
WHERE OUR FUNDS ARE USED BY

269
00:11:18,120 --> 00:11:19,440
MULTIPLE INSTITUTES PAIN

270
00:11:19,440 --> 00:11:21,440
RESEARCH AND SO ALL TOTAL THAT

271
00:11:21,440 --> 00:11:24,800
GAVE US INCREASE OF 2.6 BILLION

272
00:11:24,800 --> 00:11:28,560
OVERALL INCREASE TO 3.9 PERSES.

273
00:11:28,560 --> 00:11:33,480
WE ALSO MANAGE 10% OF THE

274
00:11:33,480 --> 00:11:35,680
DEMENTIA BUDGET TO THE AGING

275
00:11:35,680 --> 00:11:38,360
INSTITUTE WHICH IS NOW UPWARDS

276
00:11:38,360 --> 00:11:42,160
OF $274 MILLION A YEAR. SO

277
00:11:42,160 --> 00:11:45,000
REALLY HAPPY ABOUT THESE NEW

278
00:11:45,000 --> 00:11:46,200
RESOURCES, ABLE TO CONTINUE OUR

279
00:11:46,200 --> 00:11:48,440
PAY LINE AT THE 14 PERCENTILE,

280
00:11:48,440 --> 00:11:49,800
AND LOOKING FORWARD IN THE

281
00:11:49,800 --> 00:11:56,200
ENSUING YEARS TO INCREASE THAT.

282
00:11:56,200 --> 00:11:57,920
SO AGAIN HERE THE SAME BUDGET

283
00:11:57,920 --> 00:11:59,400
ITEMS, HERE IS BRAIN, THE CURES

284
00:11:59,400 --> 00:12:01,320
ACT MONEY WHICH IS ALSO FOR

285
00:12:01,320 --> 00:12:04,800
BRAIN, THIS IS THE BASE OF THE

286
00:12:04,800 --> 00:12:05,920
NINDS BUDGETS FOR BRAIN,

287
00:12:05,920 --> 00:12:07,200
ADDITIONAL FUNDS FOR CURES ACT

288
00:12:07,200 --> 00:12:11,360
THAT INSPIRES 2026, THIS IS THE

289
00:12:11,360 --> 00:12:14,840
HEAL MONEY FOR RESEARCH TO

290
00:12:14,840 --> 00:12:16,360
DEVELOP BETTER NON-ADDICTIVE

291
00:12:16,360 --> 00:12:18,240
THERAPIES FOR PAIN AND THAT IS

292
00:12:18,240 --> 00:12:23,840
TOTAL BUDGET. I WILL GO THROUGH

293
00:12:23,840 --> 00:12:25,600
A NUMBER OF EYE TESTIMONIES, THE

294
00:12:25,600 --> 00:12:26,960
COUNCIL COULD BE MADE AWARE OF

295
00:12:26,960 --> 00:12:31,200
-- ITEMS, THE FIRST IS THE

296
00:12:31,200 --> 00:12:32,240
CONGRESS STRENGTH NIH ABILITY TO

297
00:12:32,240 --> 00:12:34,200
ADDRESS HARASSMENT AND NIH

298
00:12:34,200 --> 00:12:38,080
FUNDED ACTIVITIES, WITHIN NIH

299
00:12:38,080 --> 00:12:43,280
AND IN OUR GRANTEE INSTITUTIONS.

300
00:12:43,280 --> 00:12:44,480
THE NEW AUTHORITY ENABLES

301
00:12:44,480 --> 00:12:45,560
MANDATORY REPORTING TO NIH

302
00:12:45,560 --> 00:12:47,760
REMOVALS OF DISCIPLINARY ACTIONS

303
00:12:47,760 --> 00:12:49,440
WHEN 30 DAYS OF OCCURRENCE AT

304
00:12:49,440 --> 00:12:52,560
INSTITUTIONS WE FUND. ENSURES

305
00:12:52,560 --> 00:12:54,400
NIH IS MADE AWARE OF THE REASON

306
00:12:54,400 --> 00:12:55,480
FOR DISCIPLINARY ACTION WHEN

307
00:12:55,480 --> 00:12:58,240
THERE ARE CONCERNS OF

308
00:12:58,240 --> 00:13:02,600
HARASSMENT, RETALIATION,

309
00:13:02,600 --> 00:13:03,480
BULLYING OR HOSTILE WORKING

310
00:13:03,480 --> 00:13:05,240
CONDITIONS SO THIS WILL HELP

311
00:13:05,240 --> 00:13:09,320
ADVANCE OUR GOAL TO MAKE OUR

312
00:13:09,320 --> 00:13:15,920
RESEARCH THE RESEARCH WE FUND

313
00:13:15,920 --> 00:13:17,040
IMPORTANTED ENVIRONMENTS THAT

314
00:13:17,040 --> 00:13:20,760
ARE WELCOMING TO ALL AND

315
00:13:20,760 --> 00:13:22,120
CONDUCIVE TO EVERYBODY MAKING

316
00:13:22,120 --> 00:13:25,280
THE BEST CONTRIBUTION THEY CAN

317
00:13:25,280 --> 00:13:27,800
TO OUR SCIENCE. IN ADDITION,

318
00:13:27,800 --> 00:13:33,280
THERE IS IN THE NEWS AND HAS

319
00:13:33,280 --> 00:13:34,240
BEEN IN THE BUDGET FUNDING FOR A

320
00:13:34,240 --> 00:13:42,400
NEW AGENCY, WHICH IS INSIDE NIH

321
00:13:42,400 --> 00:13:44,240
BUT REPORTS DIRECTLY TO THE

322
00:13:44,240 --> 00:13:45,440
SECRETARY OF HEALTH AS OPPOSED

323
00:13:45,440 --> 00:13:49,280
TO THE NIH DIRECTOR. THIS IS THE

324
00:13:49,280 --> 00:13:51,360
ADVANCE RESEARCH AGENCY PROJECT

325
00:13:51,360 --> 00:13:54,360
FOR HEALTH AND IT IS KIND OF

326
00:13:54,360 --> 00:13:56,760
MODELS OR SUPPOSED TO BE MODELED

327
00:13:56,760 --> 00:14:03,400
ON THE DEFENSE AGENCY. DARPA.

328
00:14:03,400 --> 00:14:05,200
THERE IS IHARP FOR THE

329
00:14:05,200 --> 00:14:07,000
INTELLIGENCE AGENCIES. THE IDEA

330
00:14:07,000 --> 00:14:11,080
IS THESE PROGRAMS SUPPORT

331
00:14:11,080 --> 00:14:13,120
TRANSFORMATIVE HIGH RISK HIGH

332
00:14:13,120 --> 00:14:14,400
REWARD RESEARCH TO SPEED

333
00:14:14,400 --> 00:14:15,480
APPLICATION AND IMPLEMENTATION

334
00:14:15,480 --> 00:14:16,480
OF HEALTH BREAK THROUGHS TO

335
00:14:16,480 --> 00:14:19,320
SERVE ALL PATIENTS TO FOSTER

336
00:14:19,320 --> 00:14:23,520
BREAK THROUGHS ACROSS VARIOUS

337
00:14:23,520 --> 00:14:25,520
LEVELS FOR SOCIETAL AND BROAD

338
00:14:25,520 --> 00:14:30,360
SCOPE AND TO BE ABLE TO BUILD

339
00:14:30,360 --> 00:14:31,040
PLATFORMS THAT WILL BENEFIT A

340
00:14:31,040 --> 00:14:32,600
RANGE OF DISEASES SO I THINK THE

341
00:14:32,600 --> 00:14:34,720
IDEA IS TO BUILD THINGS THAT CAN

342
00:14:34,720 --> 00:14:36,880
FLOAT ALL BOATS IN TERMS OF

343
00:14:36,880 --> 00:14:38,120
MOVING THINGS PARTICULARLY

344
00:14:38,120 --> 00:14:41,200
TOWARDS A TRANSLATIONAL END OF

345
00:14:41,200 --> 00:14:42,880
THINGS. AS YOU MAY RECALL WE

346
00:14:42,880 --> 00:14:45,560
WORK WITH DARPA WHERE THEY

347
00:14:45,560 --> 00:14:47,480
PRODUCE A FANTASTIC PROSTHETIC

348
00:14:47,480 --> 00:14:49,240
ARM FOR PEOPLE WHO HAD

349
00:14:49,240 --> 00:14:53,400
AMPUTATIONS OF THE UPPER LIMB

350
00:14:53,400 --> 00:14:56,360
AND WE WORK HAD GRANTS FOR

351
00:14:56,360 --> 00:14:59,440
PEOPLE TO WORK THOSE PROSTHETIC

352
00:14:59,440 --> 00:15:00,120
ARMS INTO INTERFACE SYSTEMS WITH

353
00:15:00,120 --> 00:15:02,280
THE NERVOUS SYSTEM, REALLY

354
00:15:02,280 --> 00:15:06,800
WONDERFUL PROJECT.  AND THE IDEA

355
00:15:06,800 --> 00:15:08,440
IS TO MOVE IDEAS INTO TANGIBLE

356
00:15:08,440 --> 00:15:11,560
SOLUTIONS FOR PATIENTS SO IT IS

357
00:15:11,560 --> 00:15:15,080
ON THIS BORDER ZONE OF MOVING

358
00:15:15,080 --> 00:15:17,880
THINGS OUT TOWARDS

359
00:15:17,880 --> 00:15:18,760
COMMERCIALIZATION AND TO

360
00:15:18,760 --> 00:15:20,480
OVERCOME MARKET FAILURES THROUGH

361
00:15:20,480 --> 00:15:21,760
CRITICAL SOLUTIONS AND

362
00:15:21,760 --> 00:15:22,880
INCENTIVES.  CERTAINLY IN THE

363
00:15:22,880 --> 00:15:24,200
NEUROSCIENCE SPACE THERE IS A

364
00:15:24,200 --> 00:15:28,200
LARGE NUMBER OF MARKET FAILURES

365
00:15:28,200 --> 00:15:29,800
ACTUALLY LOT OF COMPANIES LEFT

366
00:15:29,800 --> 00:15:35,640
THE NEUROSCIENCE SPACE BECAUSE

367
00:15:35,640 --> 00:15:38,440
IT WAS HIGH RISK. SO WE HOPE

368
00:15:38,440 --> 00:15:39,400
NEUROSCIENCE BENEFITS FROM THE

369
00:15:39,400 --> 00:15:45,240
NEW AGENCY. WE DON'T HAVE A GOOD

370
00:15:45,240 --> 00:15:47,840
IDEA WHERE IT WILL BE. THERE'S

371
00:15:47,840 --> 00:15:49,240
TALK OF HAVING IT IN ANOTHER

372
00:15:49,240 --> 00:15:50,760
PART OF THE COUNTRY TO TRY AND

373
00:15:50,760 --> 00:15:54,680
MAKE IT DIFFERENT FROM WHAT NIH

374
00:15:54,680 --> 00:15:57,200
DOES IN ITS USUAL MECHANISMS. 

375
00:15:57,200 --> 00:15:58,720
NOT SUPPOSED TO BE DUPLICATIVE

376
00:15:58,720 --> 00:16:02,520
OF NIH PROGRAMS AND EFFORTS SO

377
00:16:02,520 --> 00:16:04,480
LOOKING FORWARD TO DIRECTOR

378
00:16:04,480 --> 00:16:06,640
BEING NAME AND HOPEFULLY THINGS

379
00:16:06,640 --> 00:16:11,160
MOVE FORWARD QUICKLY FROM THERE.

380
00:16:11,160 --> 00:16:12,320
TIME IS SHORT SO THIS WAS PUT

381
00:16:12,320 --> 00:16:14,960
OUT IN OSTP IN 2021 IN A PAPER.

382
00:16:14,960 --> 00:16:17,680
CONGRESS PASS AD BILL IN MARCH

383
00:16:17,680 --> 00:16:21,400
OF 2022. THE AGENCY WAS

384
00:16:21,400 --> 00:16:23,960
TRANSFERRED TO NIH AS I

385
00:16:23,960 --> 00:16:25,320
MENTIONED, THE OFFICE OF

386
00:16:25,320 --> 00:16:26,280
DIRECTOR STILL HAS TO BE

387
00:16:26,280 --> 00:16:28,080
APPOINTED. I THINK THAT DR.

388
00:16:28,080 --> 00:16:30,960
COLLINS IS NOW OSTP AND WORKING

389
00:16:30,960 --> 00:16:32,760
ON BOTH TRYING TO FIND THIS

390
00:16:32,760 --> 00:16:37,200
CANDIDATE AND ALSO CANDIDATE FOR

391
00:16:37,200 --> 00:16:41,520
THE NIH DIRECTOR. WE WILL JUMP

392
00:16:41,520 --> 00:16:44,000
NOW TO A SITUATION WITH REGARD

393
00:16:44,000 --> 00:16:45,920
TO THE SYNDROMES THAT ARE

394
00:16:45,920 --> 00:16:47,200
OCCURRING AT PEOPLE AFTER THE

395
00:16:47,200 --> 00:16:48,680
COVID INFECTION. WE CALL THE

396
00:16:48,680 --> 00:16:51,760
POST ACUTE SEQUELAE OF COVID.

397
00:16:51,760 --> 00:16:55,720
SOME OF THESE ARE CONDITIONS WE

398
00:16:55,720 --> 00:16:59,560
KNOW, DIABETES, SOME OF THESE

399
00:16:59,560 --> 00:17:02,880
ARE CONDITIONS THAT REALLY

400
00:17:02,880 --> 00:17:08,120
RESEMBLE MYALGIC ENCEPHMYELITIS

401
00:17:08,120 --> 00:17:11,400
SYNDROME WITH DIFFERENT SYMPTOM

402
00:17:11,400 --> 00:17:14,080
CLUSTERS WITH FATIGUE, AND

403
00:17:14,080 --> 00:17:16,320
NEUROLOGIC PROBLEMS

404
00:17:16,320 --> 00:17:19,000
CONCENTRATION MEMORY, PAIN

405
00:17:19,000 --> 00:17:20,600
CONDITIONS, AUTONOMIC

406
00:17:20,600 --> 00:17:24,480
DYSFUNCTION, SLEEP DISORDERS, IN

407
00:17:24,480 --> 00:17:29,720
THE NEUROSPACE. SO WE HAVE BEEN

408
00:17:29,720 --> 00:17:31,680
INSTRUCTED BY CONGRESS TO REALLY

409
00:17:31,680 --> 00:17:33,360
PUT TOGETHER RESEARCH THAT CAN

410
00:17:33,360 --> 00:17:36,760
UNDERSTAND WHAT IS THE BIOLOGY

411
00:17:36,760 --> 00:17:39,120
UNDERLYING THE POOR RECOVERY IN

412
00:17:39,120 --> 00:17:40,280
PATIENTS OVER TIME TO FIND THE

413
00:17:40,280 --> 00:17:43,120
RISK FACTORS, THE DIFFERENT SUB

414
00:17:43,120 --> 00:17:46,120
PHENOTYPES, TRYING TO UNDERSTAND

415
00:17:46,120 --> 00:17:49,600
THE PATHOGENESIS OF THESE

416
00:17:49,600 --> 00:17:51,120
PHENOTYPES AND WHAT ORGAN

417
00:17:51,120 --> 00:17:52,800
SYSTEMS ARE DYSFUNCTIONAL AND

418
00:17:52,800 --> 00:17:56,160
THEN TO USE THAT KNOWLEDGE TO

419
00:17:56,160 --> 00:17:58,120
IDENTIFY INTERVENTIONS TO REDUCE

420
00:17:58,120 --> 00:17:59,280
SUFFERING WHICH IS AFFECTING

421
00:17:59,280 --> 00:18:02,240
LARGE NUMBERS OF PEOPLE WHO ARE

422
00:18:02,240 --> 00:18:06,240
NO LONGER ACUTELY AFFECT BUT

423
00:18:06,240 --> 00:18:07,080
STILL SUFFERING FROM MANY

424
00:18:07,080 --> 00:18:09,320
SYMPTOMS. SO H IS MAJOR PROJECT

425
00:18:09,320 --> 00:18:11,760
NINDS HAS BEEN WORKING WITH

426
00:18:11,760 --> 00:18:16,680
NHLBI AND NIAID ON. WE HAVE

427
00:18:16,680 --> 00:18:18,440
COHORT STUDY BRINGING IN PEOPLE

428
00:18:18,440 --> 00:18:20,840
TO BE STUDIED, WE ARE LOOKING

429
00:18:20,840 --> 00:18:22,520
FOR TENS OF THOUSANDS OF PEOPLE,

430
00:18:22,520 --> 00:18:25,480
SOME ACUTELY INFECTED, STUDY HOW

431
00:18:25,480 --> 00:18:27,760
YOU RECOVER SOME PEOPLE WHO ARE

432
00:18:27,760 --> 00:18:29,000
AFFECTED IN THE PAST STILL

433
00:18:29,000 --> 00:18:30,600
HAVING TROUBLES, COMPARED TO

434
00:18:30,600 --> 00:18:33,240
PEOPLE WHO WERE INFECTED IN THE

435
00:18:33,240 --> 00:18:35,440
PAST AND NOT HAVING TROUBLE, IT

436
00:18:35,440 --> 00:18:36,680
WAS AN OPPORTUNITY TO TEASE

437
00:18:36,680 --> 00:18:40,280
APART WHAT IS THE BIOLOGY

438
00:18:40,280 --> 00:18:41,080
DIFFERENTIATES THOSE GROUPS OF

439
00:18:41,080 --> 00:18:45,960
PEOPLE. WE ARE NOW UP TO 3,000

440
00:18:45,960 --> 00:18:47,440
PARTICIPANTS MANY THE COHORT

441
00:18:47,440 --> 00:18:49,520
SYSTEM, WE HAVE ELECTRONIC

442
00:18:49,520 --> 00:18:50,840
HEALTH RECORD SYSTEMS THAT SCAN

443
00:18:50,840 --> 00:18:53,880
AND DO RESEARCH ON RECORDS OF

444
00:18:53,880 --> 00:18:56,360
ABOUT 60 MILLION PEOPLE, OF

445
00:18:56,360 --> 00:19:00,120
COURSE THE U.S. AND WE HAVE A

446
00:19:00,120 --> 00:19:04,080
CALL OUT AND ACTUALLY GRANT --

447
00:19:04,080 --> 00:19:06,040
PROPOSAL TO COME IN, FOR STUDIES

448
00:19:06,040 --> 00:19:08,000
TO TRY TO UNDERSTAND THE

449
00:19:08,000 --> 00:19:09,440
PATHOGENESIS WHETHER IT IS

450
00:19:09,440 --> 00:19:10,840
IMMUNE SYSTEM, NEUROLOGICAL

451
00:19:10,840 --> 00:19:14,280
SYSTEM, MENTAL HEALTH DISORDERS,

452
00:19:14,280 --> 00:19:16,080
GI TROUBLE, YOU NAME IT. IN

453
00:19:16,080 --> 00:19:18,400
TERMS OF WHAT IS UNDERLYING

454
00:19:18,400 --> 00:19:21,600
THESE SYMPTOMS OF PEOPLE STILL

455
00:19:21,600 --> 00:19:22,920
SUFFERING FROM MONTHS AFTER

456
00:19:22,920 --> 00:19:26,160
THEIR INFECTION. THERE IS A

457
00:19:26,160 --> 00:19:28,360
REPOSITORY FOR TISSUE, WE HAVE

458
00:19:28,360 --> 00:19:30,960
AN AUTOPSY COMPONENT TO THIS AS

459
00:19:30,960 --> 00:19:33,200
WELL TO LOOK INSIDE AND WITH THE

460
00:19:33,200 --> 00:19:34,560
MICROSCOPE TO TRY TO UNDERSTAND

461
00:19:34,560 --> 00:19:38,800
WHAT IS GOING ON IN PEOPLE WHO

462
00:19:38,800 --> 00:19:40,880
DIED WHO HAVE SYMPTOMS OF POST

463
00:19:40,880 --> 00:19:44,040
ACUTE SEQUELAE OF COVID. COMPARE

464
00:19:44,040 --> 00:19:46,200
THEM TO PEOPLE WHO HAD COVID AND

465
00:19:46,200 --> 00:19:49,000
MADE A GOOD RECOVERY BECAUSE IT

466
00:19:49,000 --> 00:19:52,120
IS AFFECTED SO MANY PEOPLE WE

467
00:19:52,120 --> 00:19:55,640
THINK THIS IS GOING TO BE

468
00:19:55,640 --> 00:19:57,600
FRUITFUL BECAUSE PEOPLE DIE OF

469
00:19:57,600 --> 00:20:00,640
OTHER CAUSES AND WILL BE ABLE TO

470
00:20:00,640 --> 00:20:03,640
TRY TO TEASE APART IF THEY HAD

471
00:20:03,640 --> 00:20:06,200
THESE PERSISTENT SYMPTOMS VERSUS

472
00:20:06,200 --> 00:20:07,640
THOSE WHO DIDN'T WHO HAD

473
00:20:07,640 --> 00:20:08,840
PREVIOUSLY BEEN AFFECTED WITH

474
00:20:08,840 --> 00:20:12,600
COVID. NOW WE ALSO PUT OUT A

475
00:20:12,600 --> 00:20:13,760
CALL FOR CLINICAL TRIALS, I

476
00:20:13,760 --> 00:20:16,000
SUSPECT IN THE BEGINNING THESE

477
00:20:16,000 --> 00:20:20,480
MAY BE TARGETED SYMPTOMS,

478
00:20:20,480 --> 00:20:21,640
IMPROVE THE PAIN CONDITION,

479
00:20:21,640 --> 00:20:25,440
IMPROVE THE AUTONOMIC

480
00:20:25,440 --> 00:20:26,960
DYSFUNCTION, WITH POTENTIAL --

481
00:20:26,960 --> 00:20:29,920
WITH THERAPIES THAT DOCS WITHIN

482
00:20:29,920 --> 00:20:31,360
USING FOR DECADES TREATING

483
00:20:31,360 --> 00:20:33,480
PATIENTS WITH THOSE SIMILAR TYPE

484
00:20:33,480 --> 00:20:35,520
DISORDERS. AND NOW SEE WHICH ONE

485
00:20:35,520 --> 00:20:40,240
WORKS BEST IN THIS POST ACUTE

486
00:20:40,240 --> 00:20:41,240
SEQUELAE COVID SITUATION. OVER

487
00:20:41,240 --> 00:20:44,560
TIME WE HOPE TO BRING IN

488
00:20:44,560 --> 00:20:45,680
MECHANISTICALLY RATIONAL TRIALS

489
00:20:45,680 --> 00:20:48,440
TO TRY TO GET AT THE UNDERLYING

490
00:20:48,440 --> 00:20:52,880
BIOLOGY THAT CAN TURN THIS

491
00:20:52,880 --> 00:20:55,600
PROBLEM AROUND. AND ALL ITS

492
00:20:55,600 --> 00:20:56,560
MANIFESTATIONS. SO EXCITING

493
00:20:56,560 --> 00:20:57,840
PROJECT AND LOTS OF PEOPLE

494
00:20:57,840 --> 00:20:59,520
WORKING ON, I WANT TO SHOUT OUT

495
00:20:59,520 --> 00:21:02,800
TO THE NINDS TEAM THAT IS

496
00:21:02,800 --> 00:21:07,960
WORKING WITH THE NHLBI GROUP.

497
00:21:07,960 --> 00:21:11,560
NLLBI GROUP AMY PATTERSON IS THE

498
00:21:11,560 --> 00:21:15,680
MAJOR LEFT, IT IS A GREAT

499
00:21:15,680 --> 00:21:17,800
COLLABORATION. I WANT TO TALK

500
00:21:17,800 --> 00:21:21,360
ABOUT NOW THE ACT FOR ALS SIGNED

501
00:21:21,360 --> 00:21:23,800
BY THE PRESIDENT IN DECEMBER.

502
00:21:23,800 --> 00:21:27,880
AND THEN IN THE APPROPRIATIONS

503
00:21:27,880 --> 00:21:30,360
NIH RECEIVED 25 MILLION TO THE

504
00:21:30,360 --> 00:21:34,800
OFFICE OF DIRECTOR TO LAUNCH

505
00:21:34,800 --> 00:21:37,720
IMPLEMENTATION FOR ALS, IT HAS A

506
00:21:37,720 --> 00:21:39,200
COUPLE OF COMPONENTS, THE ONE

507
00:21:39,200 --> 00:21:42,560
MENTIONED HERE IS THE BILL CALLS

508
00:21:42,560 --> 00:21:45,640
FOR THE HHS TO SET UP A PROGRAM

509
00:21:45,640 --> 00:21:47,200
THAT WOULD ENABLE PEOPLE WHO

510
00:21:47,200 --> 00:21:50,600
HAVE ALS WHO ARE NOT ELIGIBLE

511
00:21:50,600 --> 00:21:52,000
FOR RECURRENT TRIALS TO GAIN

512
00:21:52,000 --> 00:21:53,400
ACCESS TO INVESTIGATIONAL DRUGS

513
00:21:53,400 --> 00:21:56,840
THAT ARE IN PHASE 3 TRIALS. THAT

514
00:21:56,840 --> 00:21:59,960
OCCURS UNDER WHAT IS CALLED AND

515
00:21:59,960 --> 00:22:03,760
EXPANDED ACCESS APPLICATION TO

516
00:22:03,760 --> 00:22:07,480
THE FDA. SO WE SUSPECT THAT WELL

517
00:22:07,480 --> 00:22:11,520
WE KNOW FOR THE ALS CLINICAL

518
00:22:11,520 --> 00:22:13,080
TRIALS THE FOCUS IS ON PEOPLE

519
00:22:13,080 --> 00:22:16,520
WHO HAVE EARLY STAGE DISEASE. SO

520
00:22:16,520 --> 00:22:18,960
THE LARGEST PERCENTAGE OF PEOPLE

521
00:22:18,960 --> 00:22:22,800
WITH ALS ARE NOT ELIGIBLE

522
00:22:22,800 --> 00:22:24,040
BECAUSE THEY PASS THAT WINDOW SO

523
00:22:24,040 --> 00:22:27,640
THE THOUGHT IS THAT THIS GROUP

524
00:22:27,640 --> 00:22:29,640
WOULD BENEFIT BECAUSE THEY

525
00:22:29,640 --> 00:22:31,560
REALLY FEEL THEY NEED THE RIGHT

526
00:22:31,560 --> 00:22:34,960
TO TRY THESE INVESTIGATIONAL

527
00:22:34,960 --> 00:22:38,120
DRUGS. THAT IN COMBINATION WITH

528
00:22:38,120 --> 00:22:39,360
POTENTIAL TO LEARN SCIENTIFIC

529
00:22:39,360 --> 00:22:40,800
THINGS OF SCIENTIFIC VALUE BY

530
00:22:40,800 --> 00:22:43,840
STUDYING THOSE PATIENTS, IS WHAT

531
00:22:43,840 --> 00:22:49,720
WE HOPE TO ACHIEVE BY EXECUTING

532
00:22:49,720 --> 00:22:52,760
OUR PART OF THIS BILL WHICH IS

533
00:22:52,760 --> 00:22:54,320
TO FUND CLINICAL -- IMPORTANT

534
00:22:54,320 --> 00:22:56,080
CLINICAL RESEARCH UNDER EXPANDED

535
00:22:56,080 --> 00:23:00,280
ACCESS IN PEOPLE WHO HAVE ALS

536
00:23:00,280 --> 00:23:01,280
NOT ELIGIBLE FOR CLINICAL

537
00:23:01,280 --> 00:23:03,520
TRIALS. THE ONE CAVEAT IS THE

538
00:23:03,520 --> 00:23:05,440
BILL LIMITS THE DRUGS THAT WOULD

539
00:23:05,440 --> 00:23:09,720
BE TESTED AND PAID FOR TO DRUGS

540
00:23:09,720 --> 00:23:12,880
THAT ARE IN PHASE 3 CLINICAL

541
00:23:12,880 --> 00:23:16,240
TRIALS THAT ARE FDA APPROVED

542
00:23:16,240 --> 00:23:17,280
TRIALS AND THEY HAVE TO BE

543
00:23:17,280 --> 00:23:19,000
SPONSORED BY A SMALL BUSINESS SO

544
00:23:19,000 --> 00:23:22,760
WE ARE LOOKING FOR APPLICATIONS

545
00:23:22,760 --> 00:23:27,120
NOW AND HOPE TO GET SOME

546
00:23:27,120 --> 00:23:30,520
PROJECTS GOING WITH FY 22 FUNDS.

547
00:23:30,520 --> 00:23:32,360
NEXT I WILL JUMP TO THE NIH DATA

548
00:23:32,360 --> 00:23:35,240
SHARING POLICY, I THIS THINK WE

549
00:23:35,240 --> 00:23:37,200
MENTIONED THIS BEFORE BUT THINGS

550
00:23:37,200 --> 00:23:40,400
ARE MOVING. AS WE HAVE SAID IN

551
00:23:40,400 --> 00:23:43,720
THE PAST THE POLICY GOES INTO

552
00:23:43,720 --> 00:23:46,800
EFFECT IN JANUARY 2023. SO FOR

553
00:23:46,800 --> 00:23:49,200
GRANTS TO DOCUMENT IN AFTER THAT

554
00:23:49,200 --> 00:23:51,760
POINT THEY HAVE TO SUBMIT A DATA

555
00:23:51,760 --> 00:23:53,640
MANAGEMENT SHARING PLAN THAT

556
00:23:53,640 --> 00:23:55,280
OUTLINES HOW SCIENTIFIC DATA ANY

557
00:23:55,280 --> 00:23:56,760
ACCOMPANYING METADATA WILL BE

558
00:23:56,760 --> 00:24:00,120
MANAGED AND SHARED TAKING INTO

559
00:24:00,120 --> 00:24:01,040
ACCOUNT POTENTIAL RESTRICTIONS

560
00:24:01,040 --> 00:24:02,560
OF LIMITATIONS WHETHER THEY ARE

561
00:24:02,560 --> 00:24:11,800
LEGAL OR PRIVACY AND THIS --

562
00:24:11,800 --> 00:24:14,120
THIS IS COVERING NOT JUST DATA

563
00:24:14,120 --> 00:24:16,160
THAT IS PART OF A PUBLICATION

564
00:24:16,160 --> 00:24:19,360
BUT RIGOROUS DATA THAT NIH FUNDS

565
00:24:19,360 --> 00:24:21,440
AND IS NOT PUBLISHED. SO WE WILL

566
00:24:21,440 --> 00:24:24,280
TALK ABOUT THAT IN A SECOND BUT

567
00:24:24,280 --> 00:24:26,160
WHAT IS GOING TO HAPPEN WHEN

568
00:24:26,160 --> 00:24:27,560
THESE COME IN THEY WILL BE

569
00:24:27,560 --> 00:24:30,320
JUDGED WHETHER THEY COMPLY WITH

570
00:24:30,320 --> 00:24:33,760
YOUR PLAN AND YOUR GRANT,

571
00:24:33,760 --> 00:24:39,760
COMPLIES WITH A OPEN SHARING

572
00:24:39,760 --> 00:24:40,880
POLICY AND YOUR PLAN WOULD HAVE

573
00:24:40,880 --> 00:24:45,320
TO BE APPROVED BY OUR PROGRAM

574
00:24:45,320 --> 00:24:48,280
DIRECTORS FOR US TO FUND THE

575
00:24:48,280 --> 00:24:50,280
GRANT. THINGS ARE CHANGING AND

576
00:24:50,280 --> 00:24:51,760
WE WILL HAVE TO SEE HOW THIS

577
00:24:51,760 --> 00:24:54,760
WORKS OUT BUT THE IDEA IS THAT

578
00:24:54,760 --> 00:24:56,520
THERE IS SO MUCH GOOD RIGOROUS

579
00:24:56,520 --> 00:24:58,600
DATA THAT IS JUST NOT AVAILABLE

580
00:24:58,600 --> 00:25:04,360
FOR OTHER PEOPLE TO LOOK AT, TO

581
00:25:04,360 --> 00:25:05,000
INVESTIGATE, POTENTIALLY ANALYZE

582
00:25:05,000 --> 00:25:06,400
IN A WAY THAT WAS DIFFERENT THAN

583
00:25:06,400 --> 00:25:10,920
IN THE PAPER. AND IT IS THIS

584
00:25:10,920 --> 00:25:13,320
DATA IS FUNDED BY THE GOVERNMENT

585
00:25:13,320 --> 00:25:15,760
AND SO THE FACT THAT IT IS NOT

586
00:25:15,760 --> 00:25:17,520
AVAILABLE IS A REAL PROBLEM. HOW

587
00:25:17,520 --> 00:25:20,080
TO MAKE IT USEFUL IS I THINK WE

588
00:25:20,080 --> 00:25:21,800
ARE GOING TO BE WORKING ON IT SO

589
00:25:21,800 --> 00:25:22,960
THE DATA WILL HAVE TO BE

590
00:25:22,960 --> 00:25:24,080
AVAILABLE, NOW THE QUESTION IS

591
00:25:24,080 --> 00:25:26,680
HOW DO WE MAKE IT USEFUL. SO WE

592
00:25:26,680 --> 00:25:29,440
THINK THAT RESEARCHERS NEED TO

593
00:25:29,440 --> 00:25:31,360
COME TOGETHER AS A COMMUNITY,

594
00:25:31,360 --> 00:25:34,000
OPTIMIZE COMMON DATA ELEMENTS,

595
00:25:34,000 --> 00:25:35,640
METADATA, STANDARDS, THAT WOULD

596
00:25:35,640 --> 00:25:37,560
APPLY TO THE TYPE OF DATA THAT

597
00:25:37,560 --> 00:25:39,640
THEY HAVE AS A COMMUNITY THAT

598
00:25:39,640 --> 00:25:41,040
THEY WOULD NECESSARILY BE

599
00:25:41,040 --> 00:25:43,000
SHARING BUT NOW SHARING IN A WAY

600
00:25:43,000 --> 00:25:45,080
WHERE IT IS GOING TO BE USEFUL

601
00:25:45,080 --> 00:25:47,240
TO EACH OTHER SO WE NEED TO

602
00:25:47,240 --> 00:25:48,840
STRENGTHEN THE DATA STANDARDS

603
00:25:48,840 --> 00:25:53,080
AND WE HAVE TO IDENTIFY TO SHARE

604
00:25:53,080 --> 00:25:55,640
HIGH QUALITY UNPUBLISHED DATA.

605
00:25:55,640 --> 00:25:57,240
SO SHY SILVERBURG WORKING

606
00:25:57,240 --> 00:26:01,480
HEAVILY ON PUSHING THE VALUE OF

607
00:26:01,480 --> 00:26:03,320
SHARING RIGOROUS DATA OR NO DATA

608
00:26:03,320 --> 00:26:06,280
SO IT IS DATA THAT YOU DID THE

609
00:26:06,280 --> 00:26:08,360
EXPERIMENTS, GREAT EXPERIMENTS

610
00:26:08,360 --> 00:26:10,280
YOU HAD ACCESS TO DATA, DIDN'T

611
00:26:10,280 --> 00:26:11,600
SUPPORT THE HYPOTHESIS.  YOU ARE

612
00:26:11,600 --> 00:26:13,960
NOT GOING TO PUBLISH IT. THAT IS

613
00:26:13,960 --> 00:26:15,080
REAL SHAME BECAUSE IT IS GOOD

614
00:26:15,080 --> 00:26:17,120
DATA AND OTHERS WILL GO DOWN THE

615
00:26:17,120 --> 00:26:21,800
SAME RABBIT HOLE YOU DID UNLESS

616
00:26:21,800 --> 00:26:23,200
-- OUT THERE PEOPLE KNOW ABOUT

617
00:26:23,200 --> 00:26:25,760
IT SO WORKING HARD TO TRY AND

618
00:26:25,760 --> 00:26:27,760
FIGURE OUT A SYSTEM THAT WOULD

619
00:26:27,760 --> 00:26:29,720
ALLOW THAT TO BE FINDABLE AND

620
00:26:29,720 --> 00:26:33,600
USEFUL DATA AS WELL. SO FAR NIH

621
00:26:33,600 --> 00:26:40,120
HAS BEEN DEVELOPING A REPOSTORY

622
00:26:40,120 --> 00:26:45,600
THERE ARE REPOSITORIES THAT ARE

623
00:26:45,600 --> 00:26:47,560
FUNDED THAT ARE MEETING THE

624
00:26:47,560 --> 00:26:48,680
STANDARDS NIH THINKS ARE

625
00:26:48,680 --> 00:26:51,760
IMPORTANT FOR DATA SHARING. FAIR

626
00:26:51,760 --> 00:26:55,640
PRINCIPLES. THIS IS THE LIST OF

627
00:26:55,640 --> 00:26:59,000
-- THAT ARE FUNDED BY NIH AT

628
00:26:59,000 --> 00:27:01,000
THIS POINT. THERE IS ALSO A LIST

629
00:27:01,000 --> 00:27:02,880
OF DOMAIN SPECIFIC REPOSITORIES

630
00:27:02,880 --> 00:27:04,080
THAT THE INSTITUTES HAVE. WE

631
00:27:04,080 --> 00:27:09,680
HAVE A NUMBER OF OUR OWN SET

632
00:27:09,680 --> 00:27:10,920
UNUSUALLY WITH SOME SPECIAL

633
00:27:10,920 --> 00:27:12,440
FUNDING OR OTHER PURPOSE IN

634
00:27:12,440 --> 00:27:17,560
MIND. SO AMPD, PARTNERSHIP FOR

635
00:27:17,560 --> 00:27:21,400
PARKINSONS IS A A PUBLIC PRIVATE

636
00:27:21,400 --> 00:27:22,240
PARTNERSHIP, DEPARTMENT OF

637
00:27:22,240 --> 00:27:23,960
DEFENSE TRAUMATIC BRAIN INJURY.

638
00:27:23,960 --> 00:27:25,640
BRAIN INITIATIVE OF COURSE

639
00:27:25,640 --> 00:27:27,680
MASSIVE DATA COLLECTION, THAT

640
00:27:27,680 --> 00:27:29,480
SPACE, THESE ARE REALLY NOT

641
00:27:29,480 --> 00:27:31,760
SCALABLE ACROSS THE INSTITUTE

642
00:27:31,760 --> 00:27:34,840
SCIENCE. SO WE NEED OTHER WAYS

643
00:27:34,840 --> 00:27:36,840
IN WHICH NOW THAT THE DATA HAVE

644
00:27:36,840 --> 00:27:39,000
TO BE POSTED THAT GROUPS COME

645
00:27:39,000 --> 00:27:41,520
TOGETHER TO MAKE THAT DATA

646
00:27:41,520 --> 00:27:45,760
USEFUL FOR THEIR COMMUNITY.

647
00:27:45,760 --> 00:27:48,040
THERE ARE RFAs OUT WHERE

648
00:27:48,040 --> 00:27:50,960
PEOPLE COME IN TO GET GRANTS TO

649
00:27:50,960 --> 00:27:55,440
BUILD THOSE -- THAT KIND OF

650
00:27:55,440 --> 00:27:56,960
FRAMEWORK FOR THEIR SCIENCE. ARE

651
00:27:56,960 --> 00:27:59,520
YOU HAPPY TO -- HAPPY TO WORK

652
00:27:59,520 --> 00:28:00,880
WITH ANYBODY INTERESTED IN DOING

653
00:28:00,880 --> 00:28:04,080
THAT. LYNN JAKEMAN AND PAT

654
00:28:04,080 --> 00:28:05,600
BELLGOWAN DIVISION OF

655
00:28:05,600 --> 00:28:06,640
NEUROSCIENCE ON TOP OF THOSE

656
00:28:06,640 --> 00:28:11,480
DEVELOPMENTS. THE NEXT THING TO

657
00:28:11,480 --> 00:28:14,920
JUMP TO WAS A NEW RO1 MECHANISM

658
00:28:14,920 --> 00:28:20,160
THAT WE ARE GOING TO GET OUT, IT

659
00:28:20,160 --> 00:28:24,360
IS AN RO1 FOR NEW AND AT RISK

660
00:28:24,360 --> 00:28:26,600
INVESTIGATORS TO PROMOTE WORK

661
00:28:26,600 --> 00:28:28,200
FORCE DIVERSITY. THESE ARE

662
00:28:28,200 --> 00:28:32,200
PEOPLE WHO FROM

663
00:28:32,200 --> 00:28:34,120
UNDER-REPRESENTED GROUPS IN OUR

664
00:28:34,120 --> 00:28:37,640
SCIENCE WHICH IS FOR US A REAL

665
00:28:37,640 --> 00:28:40,080
PROBLEM. ONLY 6% OF OUR

666
00:28:40,080 --> 00:28:42,240
APPLICANTS ARE UNDER-REPRESENTED

667
00:28:42,240 --> 00:28:44,240
GROUPS AND ONLY 5% OF THE

668
00:28:44,240 --> 00:28:47,520
AWARDEES ARE FROM

669
00:28:47,520 --> 00:28:50,280
UNDER-REPRESENTED GROUPS. SO

670
00:28:50,280 --> 00:28:52,360
THIS PROGRAM WHICH NIDA DRUG

671
00:28:52,360 --> 00:28:53,360
ABUSE INSTITUTE AND MENTAL

672
00:28:53,360 --> 00:28:58,400
HEALTH HAVE ALSO SIGNED ON WILL

673
00:28:58,400 --> 00:29:00,800
BE A SPECIAL RO1, ENCOURAGE MORE

674
00:29:00,800 --> 00:29:02,280
DIVERSE POOL OF PIs TO

675
00:29:02,280 --> 00:29:03,960
CONTRIBUTE. IT WILL BE FOR THOSE

676
00:29:03,960 --> 00:29:07,160
VULNERABLE PIs, FOR THOSE

677
00:29:07,160 --> 00:29:09,400
EARLY STAGE, ALSO NEW

678
00:29:09,400 --> 00:29:11,360
INVESTIGATORS, WHO MAY BE PAST

679
00:29:11,360 --> 00:29:14,560
THE EARLY STAGE TIME WINDOW. SO

680
00:29:14,560 --> 00:29:17,200
LOOKING FORWARD TO SEE HOW THIS

681
00:29:17,200 --> 00:29:18,880
CAN HELP US KIND OF ACHIEVE THIS

682
00:29:18,880 --> 00:29:22,920
GOAL OF GETTING MORE -- BETTER

683
00:29:22,920 --> 00:29:24,120
DIVERSITY INTO OUR WORK FORCE

684
00:29:24,120 --> 00:29:25,440
BECAUSE WE THINK THAT IS WHAT IS

685
00:29:25,440 --> 00:29:27,720
GOING TO HELP ADVANCE SCIENCE IN

686
00:29:27,720 --> 00:29:34,080
A MORE STRONG DIRECTION. 

687
00:29:34,080 --> 00:29:37,200
SIMILARLY, WE HAD A SIMILAR

688
00:29:37,200 --> 00:29:41,440
PROGRAM FOR BASIC SCIENCE WHEN

689
00:29:41,440 --> 00:29:43,240
WE REALIZED APPLICATIONS FOR

690
00:29:43,240 --> 00:29:46,680
BASIC SCIENCE RESEARCH WERE

691
00:29:46,680 --> 00:29:47,880
FALLING AND SO THIS IS WHAT I

692
00:29:47,880 --> 00:29:49,520
MENTIONED ABOUT THE DIVERSITY

693
00:29:49,520 --> 00:29:52,720
RO1 IS SOMEWHAT RELATED. WE WERE

694
00:29:52,720 --> 00:29:55,160
ABLE TO STEM THAT TIDE

695
00:29:55,160 --> 00:29:59,280
DECREASING BASIC SCIENCE

696
00:29:59,280 --> 00:30:00,640
APPLICATIONS, BUT WE FEEL WE

697
00:30:00,640 --> 00:30:04,000
SPEND A GREAT DEAL OF EFFORT IN

698
00:30:04,000 --> 00:30:04,920
MANY DISEASE SPACES AND THOUGHT

699
00:30:04,920 --> 00:30:06,840
IT WAS REALLY IMPORTANT TO TAKE

700
00:30:06,840 --> 00:30:08,800
A LOOK AT HOW WE SUPPORT BASIC

701
00:30:08,800 --> 00:30:10,360
NEUROSCIENCE RESEARCH. THIS IS

702
00:30:10,360 --> 00:30:12,320
RESEARCH THAT IS FUNDAMENTAL, IT

703
00:30:12,320 --> 00:30:15,080
IS NOT DISEASE AGNOSTIC BUT WHAT

704
00:30:15,080 --> 00:30:16,880
WE KNOW IS THAT THIS IS A

705
00:30:16,880 --> 00:30:19,280
FOUNDATION FOR WHAT EVERYTHING

706
00:30:19,280 --> 00:30:20,280
COMES NEXT, WHICH IS DISEASE

707
00:30:20,280 --> 00:30:23,880
FOCUS RESEARCH. SO INCREDIBLY

708
00:30:23,880 --> 00:30:25,080
IMPORTANT FOR OUR INSTITUTE THAT

709
00:30:25,080 --> 00:30:26,480
THIS IS STRONG. WHAT WE ARE

710
00:30:26,480 --> 00:30:29,280
DOING IS WE ARE PUTTING OUT A

711
00:30:29,280 --> 00:30:30,760
REQUEST FOR INFORMATION TO GET

712
00:30:30,760 --> 00:30:32,560
IDEAS ON WHAT IS IT THAT COULD

713
00:30:32,560 --> 00:30:35,280
REALLY HELP OUR BASIC

714
00:30:35,280 --> 00:30:38,520
NEUROSCIENCE RESEARCH. IS IT

715
00:30:38,520 --> 00:30:40,400
RESOURCE, IS IT DATA SYSTEMS? IS

716
00:30:40,400 --> 00:30:43,920
IT NEW TOOLS? WE LEARNED FROM

717
00:30:43,920 --> 00:30:44,840
THE BRAIN INITIATIVE HOW

718
00:30:44,840 --> 00:30:47,520
IMPORTANT TOOLS ARE. THOSE ARE

719
00:30:47,520 --> 00:30:49,840
FOCUSED ON BASICALLY

720
00:30:49,840 --> 00:30:51,040
NEUROCIRCUIT BASIC VERGE. SO

721
00:30:51,040 --> 00:30:53,120
THIS IS MORE -- RESEARCH. THIS

722
00:30:53,120 --> 00:30:54,640
IS MORE WIDE SCOPE THAN THAT.

723
00:30:54,640 --> 00:30:56,880
WHAT WE ALSO ESTABLISHED WORKING

724
00:30:56,880 --> 00:30:58,440
GROUP OF COUNCIL SO WE WILL BE

725
00:30:58,440 --> 00:31:00,120
LOOKING FOR COUNCIL MEMBERS TO

726
00:31:00,120 --> 00:31:04,320
TAKE A ROLE AS IN THIS WORKING

727
00:31:04,320 --> 00:31:05,720
GROUP TO THINK THROUGH THE

728
00:31:05,720 --> 00:31:09,280
FEEDBACK WE GET, WORK WITH US

729
00:31:09,280 --> 00:31:11,080
AND THE COUNCIL DEVELOP --

730
00:31:11,080 --> 00:31:11,840
WORKING GROUP DEVELOPS

731
00:31:11,840 --> 00:31:13,000
RECOMMENDATIONS HOW WE CAN BEST

732
00:31:13,000 --> 00:31:14,600
ADVANCE OUR FUNDAMENTAL

733
00:31:14,600 --> 00:31:16,000
NEUROSCIENCE RESEARCH. AGAIN

734
00:31:16,000 --> 00:31:19,040
LIKE ALL THE WORKING GROUPS WE

735
00:31:19,040 --> 00:31:20,160
BRING BACK THEIR RECOMMENDATIONS

736
00:31:20,160 --> 00:31:22,040
TO THE GREATER COUNCIL FOR

737
00:31:22,040 --> 00:31:24,880
DISCUSSION AND FINALLY

738
00:31:24,880 --> 00:31:25,560
EVENTUALLY APPROVAL BY THIS

739
00:31:25,560 --> 00:31:31,320
BODY. SO REALLY WANT PEOPLE TO

740
00:31:31,320 --> 00:31:33,760
THINK HARD ABOUT THIS ISSUE, IT

741
00:31:33,760 --> 00:31:34,320
IS SO IMPORTANT TO THE

742
00:31:34,320 --> 00:31:39,680
INSTITUTE.  NOW I WILL JUMP TO

743
00:31:39,680 --> 00:31:43,360
THE CLINICAL TRIAL NETWORKS. WE

744
00:31:43,360 --> 00:31:47,960
HAVE TWO THAT WERE -- WILL BE

745
00:31:47,960 --> 00:31:49,320
RECOMPETING, STROKE NET OR

746
00:31:49,320 --> 00:31:52,240
STROKE RESEARCH BOTH PHASE 1,

747
00:31:52,240 --> 00:31:55,000
PHASE 2, PHASE 3, ACUTE STROKE

748
00:31:55,000 --> 00:31:59,320
PREVENTION AND REHAB, THAT IS

749
00:31:59,320 --> 00:32:00,040
WHERE MOST CLINICAL TRIALS IS

750
00:32:00,040 --> 00:32:02,040
AND THE NEURONETWORK WHICH IS

751
00:32:02,040 --> 00:32:05,360
PHASE 2 TRIALS OF NEW THERAPIES,

752
00:32:05,360 --> 00:32:08,120
THAT REALLY COVERS THE WATER

753
00:32:08,120 --> 00:32:12,160
FRONT OF ALL OUR DISORDERS, WITH

754
00:32:12,160 --> 00:32:13,560
EXCEPTION TO STROKE TO GO INTO

755
00:32:13,560 --> 00:32:15,440
STROKE NET. BOTH ARE RUNNING,

756
00:32:15,440 --> 00:32:16,960
BOTH EVALUATED, BY THE WORKING

757
00:32:16,960 --> 00:32:22,520
GROUP OF OUR COUNCIL. AND THE

758
00:32:22,520 --> 00:32:26,640
RECOMMENDATIONS ARE GOING TO BE

759
00:32:26,640 --> 00:32:30,040
INFLUENCING HOW WE SET UP NEW

760
00:32:30,040 --> 00:32:33,440
NETWORKS, PRIORITIES ISSUE CAME

761
00:32:33,440 --> 00:32:35,160
UP LOUD AND CLEAR. THAT THE

762
00:32:35,160 --> 00:32:38,280
COUNCIL IS ASKING US MAKE IT

763
00:32:38,280 --> 00:32:44,480
MORE CLEAR TO THE COMMUNITY OF

764
00:32:44,480 --> 00:32:45,920
GRANTEES, WHAT THE PRIORITIES

765
00:32:45,920 --> 00:32:47,680
FOR RESEARCH ARE. I WILL TURN

766
00:32:47,680 --> 00:32:50,560
THAT AROUND ON THE COMMUNITY AND

767
00:32:50,560 --> 00:32:51,920
SAY WHAT YOU DON'T WANT IS THE

768
00:32:51,920 --> 00:32:54,040
GOVERNMENT TELLING YOU WHAT TO

769
00:32:54,040 --> 00:32:56,520
DO. WHAT WE DO WANT IS PEOPLE

770
00:32:56,520 --> 00:32:58,160
WORKING TOGETHER TO GO TO THE

771
00:32:58,160 --> 00:32:59,400
COMMUNITY, THE SCIENCE

772
00:32:59,400 --> 00:33:01,800
COMMUNITY, GET GOOD IDEAS, AND

773
00:33:01,800 --> 00:33:03,560
AS A GROUP COME UP WITH

774
00:33:03,560 --> 00:33:05,400
PRIORITIES AND NOT REALLY TOP

775
00:33:05,400 --> 00:33:06,480
DOWN BUT THEY ARE COMMUNITY

776
00:33:06,480 --> 00:33:08,480
BASED PRIORITIES AND THAT IS

777
00:33:08,480 --> 00:33:10,560
WHAT WE HAVE DONE IN THE PAST.

778
00:33:10,560 --> 00:33:13,520
THAT IS ALSO WHAT WE NEED TO

779
00:33:13,520 --> 00:33:16,640
KIND OF UP OUR GAME PLAN FOR

780
00:33:16,640 --> 00:33:20,760
THESE NETWORKS AND DO IN THE

781
00:33:20,760 --> 00:33:23,040
FUTURE. NETWORKS WERE SET UP TO

782
00:33:23,040 --> 00:33:24,600
IMPROVE EFFICIENCY, WE THINK

783
00:33:24,600 --> 00:33:26,080
THEY HAVE IMPROVED EFFICIENCY

784
00:33:26,080 --> 00:33:27,600
BUT THERE IS STILL A LONG WAY TO

785
00:33:27,600 --> 00:33:30,880
GO TRYING TO GET THINGS MOVING

786
00:33:30,880 --> 00:33:33,000
MORE QUICKLY. THE PREPARATION

787
00:33:33,000 --> 00:33:36,440
AND THE PROCESSES TO GET THROUGH

788
00:33:36,440 --> 00:33:37,920
THESE APPROVAL FOR CLINICAL

789
00:33:37,920 --> 00:33:40,080
TRIALS IS REALLY QUITE LONG AND

790
00:33:40,080 --> 00:33:42,280
LABORED. THEY ARE VERY EXPENSIVE

791
00:33:42,280 --> 00:33:46,320
SO WE HAVE TO BE JUDICIOUS, ALSO

792
00:33:46,320 --> 00:33:48,240
NETWORKS HAVE BANDWIDTH SO WE

793
00:33:48,240 --> 00:33:51,400
HAVE TO BE CAREFUL ON HOW MUCH

794
00:33:51,400 --> 00:33:54,760
WE GIVE THEM AT A TIME BUT

795
00:33:54,760 --> 00:33:57,000
CLEARLY WE TAKE THE MESSAGE LOUD

796
00:33:57,000 --> 00:33:58,840
AND CLEAR. A LOT WE CAN DO TO

797
00:33:58,840 --> 00:34:00,240
STREAMLINE THIS PROCESS AND WE

798
00:34:00,240 --> 00:34:02,280
WILL BE WORKING ON THAT. WE ALSO

799
00:34:02,280 --> 00:34:04,760
HAVE -- WE GOT -- WE LEARNED A

800
00:34:04,760 --> 00:34:08,920
LOT FROM THE WORKING GROUP

801
00:34:08,920 --> 00:34:12,640
INPUT, THIS WAS TEN YEAR AFTER

802
00:34:12,640 --> 00:34:14,880
TEN YEARS AN ACTUALLY GO DOWN A

803
00:34:14,880 --> 00:34:16,280
LITTLE BIT OF TIME TRYING TO

804
00:34:16,280 --> 00:34:18,080
DEVELOP A FIVE YEAR EVALUATION

805
00:34:18,080 --> 00:34:19,680
PLAN INSTEAD OF WAITING TO TEN,

806
00:34:19,680 --> 00:34:23,680
THAT MAKES A LOT OF SENSE. SO

807
00:34:23,680 --> 00:34:24,880
THANK YOU VERY MUCH TO THE

808
00:34:24,880 --> 00:34:25,880
WORKING GROUP FOR ALL THE WORK

809
00:34:25,880 --> 00:34:29,080
YOU DID ON THIS. YOU WILL SEE

810
00:34:29,080 --> 00:34:32,160
THE VALUE AS A NETWORK

811
00:34:32,160 --> 00:34:34,600
TRANSITIONS INTO NEW PHASE.

812
00:34:34,600 --> 00:34:35,720
AGAIN, THANKS TO SO MANY PEOPLE

813
00:34:35,720 --> 00:34:38,840
WHO WORKED ON THIS WORKING GROUP

814
00:34:38,840 --> 00:34:42,040
FROM COUNCIL, PAST COUNCIL,

815
00:34:42,040 --> 00:34:45,400
PARTICULARLY BARB VICRY AND

816
00:34:45,400 --> 00:34:46,880
RICK, CO-CHAIRS AND ALL THE

817
00:34:46,880 --> 00:34:50,360
FOLKS WHO WORKED FROM NIH AND

818
00:34:50,360 --> 00:34:50,960
NETWORKS REALLY PROUD OF THE

819
00:34:50,960 --> 00:34:54,200
WORK THEY DID. I WANT TO TALK

820
00:34:54,200 --> 00:34:58,040
ABOUT COUPLE OF MEETINGS COMING

821
00:34:58,040 --> 00:35:01,840
UP, THE RECENT MEETINGS WAS A

822
00:35:01,840 --> 00:35:03,440
REALLY INTERESTING BRAIN ATTACK

823
00:35:03,440 --> 00:35:05,120
COALITION SYMPOSIUM EQUITIES AND

824
00:35:05,120 --> 00:35:07,560
ACCESS TO DELIVERY TO SHOW CARE.

825
00:35:07,560 --> 00:35:09,360
-- STROKE CARE. THE BRAIN INTACT

826
00:35:09,360 --> 00:35:12,440
COALITION IS A GROUP MEETING FOR

827
00:35:12,440 --> 00:35:15,480
25 YEARS TRYING TO DEVELOP BEST

828
00:35:15,480 --> 00:35:17,800
PRACTICES FOR PRIMARILY ACUTE

829
00:35:17,800 --> 00:35:21,800
STROKE CARE AND BEGAN WITH THE

830
00:35:21,800 --> 00:35:23,880
ADVENT OF GEARED UP WITH ADVENT

831
00:35:23,880 --> 00:35:27,400
OF TPA COMING ON THE SCENE. THEY

832
00:35:27,400 --> 00:35:30,360
HAVE DONE A LOT OF WORK, MOST

833
00:35:30,360 --> 00:35:32,360
RECENTLY FOCUSED ON THIS ISSUE,

834
00:35:32,360 --> 00:35:34,560
THAT WE HAVE TO FIGURE OUT HOW

835
00:35:34,560 --> 00:35:36,880
TO CHANGE THE SYSTEM WHERE WHAT

836
00:35:36,880 --> 00:35:38,240
HAPPENS TO YOU WHEN YOU HAVE A

837
00:35:38,240 --> 00:35:41,600
STROKE DEPENDS ON WHERE YOU

838
00:35:41,600 --> 00:35:44,360
LIVE. THAT IS REALLY THIS ISSUE

839
00:35:44,360 --> 00:35:46,600
OF TRYING TO ADDRESS INEQUITIES

840
00:35:46,600 --> 00:35:49,800
IN ACCESS. THE ISSUE AS YOU KNOW

841
00:35:49,800 --> 00:35:52,560
IS THAT IN AN ACUTE ISCHEMIC

842
00:35:52,560 --> 00:35:54,280
STROKE, CHANCE OF HELPING

843
00:35:54,280 --> 00:35:57,520
SOMEONE IS REALLY QUITE LARGE,

844
00:35:57,520 --> 00:35:59,080
YOU CAN MAKE DRAMATIC HIGH

845
00:35:59,080 --> 00:36:00,560
EFFECT SIZE DIMENSIONS BUT THEY

846
00:36:00,560 --> 00:36:03,520
HAVE TO BE EXECUTED WITHIN HOURS

847
00:36:03,520 --> 00:36:05,880
AND MINUTES IS EVEN BETTER, BUT

848
00:36:05,880 --> 00:36:07,280
THEY HAVE -- THEY HAVE THIS

849
00:36:07,280 --> 00:36:08,760
REALLY QUICK TIME LINE, IF YOU

850
00:36:08,760 --> 00:36:12,120
ARE NOT IN A PLACE THATTING SOD

851
00:36:12,120 --> 00:36:13,640
YOU MISS OUT ON THE OPPORTUNITY

852
00:36:13,640 --> 00:36:16,960
AND UNFORTUNATELY CAN SUFFER

853
00:36:16,960 --> 00:36:18,080
MASSIVE BRAIN DAMAGE AND NEVER

854
00:36:18,080 --> 00:36:21,440
REALLY RECOVER TO ABLE TO TAKE

855
00:36:21,440 --> 00:36:23,240
CARE OF YOURSELF AGAIN. SO IT IS

856
00:36:23,240 --> 00:36:25,560
REALLY A TERRIBLE INEQUITY, HOW

857
00:36:25,560 --> 00:36:27,560
TO FIX I THINK WORKING WITH

858
00:36:27,560 --> 00:36:28,520
HEALTHCARE SYSTEMS, THERE ARE A

859
00:36:28,520 --> 00:36:30,200
LOT OF THINGS YOU CAN DO, THERE

860
00:36:30,200 --> 00:36:35,000
IS A LOT OF MODELS OUT THERE. WE

861
00:36:35,000 --> 00:36:37,280
HAVE THE ALZHEIMER'S RELATED

862
00:36:37,280 --> 00:36:38,920
DEMENTIA SUMMIT, YOU WILL HEAR

863
00:36:38,920 --> 00:36:40,240
ABOUT THEM IN SEPTEMBER ABOUT

864
00:36:40,240 --> 00:36:41,160
THE RECOMMENDATIONS THAT CAME

865
00:36:41,160 --> 00:36:44,360
OUT OF THAT. FOR THE ALZHEIMER'S

866
00:36:44,360 --> 00:36:45,960
DISEASE RELATED RESEARCH THAT WE

867
00:36:45,960 --> 00:36:48,240
CAN NOW DO AT A LEVEL WE CAN

868
00:36:48,240 --> 00:36:51,000
NEVER HAVE IMAGINED BEFORE WITH

869
00:36:51,000 --> 00:36:54,080
THE FUNDING THAT COMES FROM THE

870
00:36:54,080 --> 00:36:55,440
AGING INSTITUTE MANAGED FOR

871
00:36:55,440 --> 00:36:57,400
THESE PROGRAMS THAT ARE MANAGED

872
00:36:57,400 --> 00:37:01,560
BY NINDS. AND THEN OUR GROUP

873
00:37:01,560 --> 00:37:04,000
INSIDE IS PUT TOGETHER A REALLY

874
00:37:04,000 --> 00:37:06,880
GREAT WEBINAR SERIES FOR PEOPLE

875
00:37:06,880 --> 00:37:09,240
WHO ARE INTERESTED IN

876
00:37:09,240 --> 00:37:13,760
UNDERSTANDING HOW TO NEGOTIATE

877
00:37:13,760 --> 00:37:18,280
THE NIH SYSTEM PARTICULARLY FOR

878
00:37:18,280 --> 00:37:21,000
THOSE PEOPLE FROM DISADVANTAGED

879
00:37:21,000 --> 00:37:28,320
COMMUNITIES.  THEN COMING UP ARE

880
00:37:28,320 --> 00:37:29,520
REALLY IMPORTANT CONFERENCE NEXT

881
00:37:29,520 --> 00:37:32,040
WEEK CALLED CATALYZING

882
00:37:32,040 --> 00:37:35,080
COMMUNITIES OF RESEARCH RIGOR

883
00:37:35,080 --> 00:37:37,760
CHAMPIONS, THIS IS ONE BY SHI

884
00:37:37,760 --> 00:37:40,760
AND DEVIN CRAWFORD, THEY ARE

885
00:37:40,760 --> 00:37:45,760
WORKING HARD TO PROMULGATE

886
00:37:45,760 --> 00:37:47,080
RIGOROUS SCIENCE IN THE DESIGN

887
00:37:47,080 --> 00:37:53,080
AND ANALYSIS OF HOW PEOPLE DO

888
00:37:53,080 --> 00:37:55,120
EXPERIMENTS AS YOU WILL SEE IN

889
00:37:55,120 --> 00:37:57,480
CLOSED SESSION WE WILL BE

890
00:37:57,480 --> 00:37:59,920
LOOKING AT GRANTS TO FUND

891
00:37:59,920 --> 00:38:01,440
CENTERS THAT WOULD DEVELOP

892
00:38:01,440 --> 00:38:03,640
EDUCATION MATERIALS AND IMPROVE

893
00:38:03,640 --> 00:38:07,040
RIGOR CENTERED TO EVALUATE AND

894
00:38:07,040 --> 00:38:09,560
VALIDATE THESE AND WE REALLY

895
00:38:09,560 --> 00:38:12,720
WANT TO CREATE A NEW CULTURE

896
00:38:12,720 --> 00:38:14,920
WHICH PUTS THE QUALITY AND RIGOR

897
00:38:14,920 --> 00:38:18,360
OF THE SCIENCE AT THE TOP OF

898
00:38:18,360 --> 00:38:20,120
GOAL IN TRAINING AND ACTUALLY

899
00:38:20,120 --> 00:38:23,600
THE EXECUTION OF SCIENCE IN THE

900
00:38:23,600 --> 00:38:26,120
LABORATORY. SO LOOKING FORWARD

901
00:38:26,120 --> 00:38:29,000
TO THIS CONFERENCE NEXT WEEK. WE

902
00:38:29,000 --> 00:38:32,000
HAVE OUR NON-PROFIT FORUM COMING

903
00:38:32,000 --> 00:38:37,040
UP IN THE SUMMER WHICH BRINGS IN

904
00:38:37,040 --> 00:38:38,920
GROUPS FROM 70 DIFFERENT

905
00:38:38,920 --> 00:38:41,200
DISEASES ADVOCACY ORGANIZATIONS

906
00:38:41,200 --> 00:38:43,720
THAT REPRESENT PATIENTS OF MANY

907
00:38:43,720 --> 00:38:46,280
DIFFERENT DISORDERS WHERE WE GET

908
00:38:46,280 --> 00:38:49,720
REAL INPUT VALUABLE INPUT FROM

909
00:38:49,720 --> 00:38:52,280
THE GROUND UP FROM THE PATIENTS

910
00:38:52,280 --> 00:38:54,560
THEMSELVES AND THEIR CAREGIVERS 

911
00:38:54,560 --> 00:38:57,200
THE BRAIN INITIATIVE

912
00:38:57,200 --> 00:38:58,120
INVESTIGATION MEETING ALSO

913
00:38:58,120 --> 00:38:59,520
FANTASTIC MEETING WHERE THE NEW

914
00:38:59,520 --> 00:39:00,600
TOOLS AND SCIENCE COMING OUT OF

915
00:39:00,600 --> 00:39:02,440
THE BRAIN INITIATIVE IS

916
00:39:02,440 --> 00:39:04,920
PRESENTED AND DISCUSSED, THAT IS

917
00:39:04,920 --> 00:39:06,440
COMING UP IN JUNE, THAT WILL BE

918
00:39:06,440 --> 00:39:09,880
A HYBRID MEETINGING. THE PAIN

919
00:39:09,880 --> 00:39:11,640
MANAGEMENT THROUGH THE LENS OF

920
00:39:11,640 --> 00:39:12,880
WHOLE PERSON HELP SYMPOSIUM FOR

921
00:39:12,880 --> 00:39:16,120
THE PAIN CONSORTIUM WHICH IS THE

922
00:39:16,120 --> 00:39:18,040
TRANS-NIH GROUP OF INSTITUTES

923
00:39:18,040 --> 00:39:19,520
WORKING IN PAIN. THAT IS OUR

924
00:39:19,520 --> 00:39:22,800
ANNUAL MEETING THERE. SO GOOD

925
00:39:22,800 --> 00:39:25,360
STUFF COMING UP QUESTION SPITE

926
00:39:25,360 --> 00:39:29,960
COVID. SPEAKING OF COVID WE

927
00:39:29,960 --> 00:39:34,240
CERTAINLY WANT TO GIVE A REAL

928
00:39:34,240 --> 00:39:36,200
CHEER TO OUR STAFF WHO WORKED

929
00:39:36,200 --> 00:39:38,320
THROUGH COVID, DIFFICULT TIMES

930
00:39:38,320 --> 00:39:40,280
BUT HAVE DONE A REALLY

931
00:39:40,280 --> 00:39:41,400
RETREMENDOUS JOB. THINKING ABOUT

932
00:39:41,400 --> 00:39:45,080
THE FUTURE WORK A LOT WE HAVE

933
00:39:45,080 --> 00:39:46,480
BEEN THINKING HOW TO WORK AS AN

934
00:39:46,480 --> 00:39:48,280
INSTITUTE BUT WE WANT TO ASK YOU

935
00:39:48,280 --> 00:39:50,600
ABOUT HOW SHOULD WE WORK AS A

936
00:39:50,600 --> 00:39:51,880
COUNCIL. SO WE KNOW SOME THINGS

937
00:39:51,880 --> 00:39:54,880
ABOUT VIRTUAL MEETINGS NOW THE

938
00:39:54,880 --> 00:39:57,360
PROS AND THE CONS AND WE LIKE TO

939
00:39:57,360 --> 00:40:02,280
DO NOW IS TO HEAR FROM PEOPLE

940
00:40:02,280 --> 00:40:04,520
ABOUT WHAT YOU EACH SHOULD DO IN

941
00:40:04,520 --> 00:40:06,080
THE FUTURE TO DO FOR COUNCIL.

942
00:40:06,080 --> 00:40:07,800
WHAT DO YOU LIKE ABOUT THE

943
00:40:07,800 --> 00:40:08,960
VIRTUAL MEETING, WHAT DO YOU

944
00:40:08,960 --> 00:40:10,480
MISS ABOUT THE IN PERSON

945
00:40:10,480 --> 00:40:11,440
MEETING. WHAT DO YOU THINK THE

946
00:40:11,440 --> 00:40:13,240
VALUE IS OF IN PERSON VERSUS

947
00:40:13,240 --> 00:40:14,240
HYBRID MEETINGS? AND WHAT WOULD

948
00:40:14,240 --> 00:40:17,120
YOU LIKE TO SEE IN THE FUTURE? 

949
00:40:17,120 --> 00:40:18,280
JUST JUMPING THE GUN A LITTLE

950
00:40:18,280 --> 00:40:22,480
BIT, I THINK THAT GUESSING BUT

951
00:40:22,480 --> 00:40:23,720
WE WILL SEE BUT WE WANT TO

952
00:40:23,720 --> 00:40:25,960
UNDERSTAND WHAT YOU THINK ABOUT

953
00:40:25,960 --> 00:40:27,760
WHAT IS THE OPTIMAL BALANCE

954
00:40:27,760 --> 00:40:31,880
BETWEEN VIRTUAL HYBRID AND IN

955
00:40:31,880 --> 00:40:33,200
PERSON MEETINGS NOT JUST

956
00:40:33,200 --> 00:40:34,680
INDIVIDUAL MEETING IS IMPORTANT

957
00:40:34,680 --> 00:40:36,600
BUT WHAT ABOUT BALANCE OVER THE

958
00:40:36,600 --> 00:40:38,360
YEARS, SOME MEETINGS IN PERSON

959
00:40:38,360 --> 00:40:41,080
AND SOME ARE VIRTUAL, SOME

960
00:40:41,080 --> 00:40:42,920
HYBRID. SO REALLY OPEN THIS UP

961
00:40:42,920 --> 00:40:44,480
FOR DISCUSSION. AND WITH THAT I

962
00:40:44,480 --> 00:40:46,560
WANT TO THANK YOU AND LET'S TALK

963
00:40:46,560 --> 00:40:47,960
ABOUT WHAT PEOPLE THINK ABOUT

964
00:40:47,960 --> 00:40:50,240
COUNCIL IN THE FUTURE. THANK YOU

965
00:40:50,240 --> 00:40:52,160
VERY MUCH.

966
00:40:52,160 --> 00:40:54,080
>> WE TAKE DOWN THE SLIDE
AND WE

967
00:40:54,080 --> 00:40:55,360
HAVE --

968
00:40:55,360 --> 00:40:59,880
>> HAPPY TO ANSWER ANY

969
00:40:59,880 --> 00:41:00,800
QUESTIONS. AND THEN I THINK WHAT

970
00:41:00,800 --> 00:41:02,440
WE WOULD LIKE TO DO IS CALL ON

971
00:41:02,440 --> 00:41:04,440
PEOPLE GETTING THEIR ADVICE

972
00:41:04,440 --> 00:41:05,880
ABOUT FUTURE COUNCIL MEETINGS

973
00:41:05,880 --> 00:41:06,840
AND HOW THEY WOULD LIKE TO SEE

974
00:41:06,840 --> 00:41:12,800
THEM. 

975
00:41:12,800 --> 00:41:14,160
>> SAMEER WAS FIRST.

976
00:41:14,160 --> 00:41:15,800
>> BEAT YOU BY A FRACTION
OF A

977
00:41:15,800 --> 00:41:18,560
SECOND.

978
00:41:18,560 --> 00:41:21,800
>> I THINK REGARDING
COUNCIL, I

979
00:41:21,800 --> 00:41:24,920
HAVE NOT BEEN IN AND IN PERSON

980
00:41:24,920 --> 00:41:27,080
COUNCIL MEETING. BEEN IN OTHER

981
00:41:27,080 --> 00:41:29,080
MEETINGS THAT HAPPEN IN PERSON

982
00:41:29,080 --> 00:41:33,920
SO I SUPPOSE MY VOTE FOR WHAT

983
00:41:33,920 --> 00:41:35,000
IT'S WORTH IS WHEN WE ARE ABLE

984
00:41:35,000 --> 00:41:37,720
TO DO SO I WOULD LOVE TO DO

985
00:41:37,720 --> 00:41:42,160
THAT. IT IS OBVIOUSLY A LOT MORE

986
00:41:42,160 --> 00:41:44,160
-- LESS COMMUTING IN TERMS OF

987
00:41:44,160 --> 00:41:47,000
TRAVEL TIME AND EXPENSE AND

988
00:41:47,000 --> 00:41:47,920
CARBON FOOTPRINT AND THAT STUFF

989
00:41:47,920 --> 00:41:49,800
BUT THERE IS A REAL VALUE TO

990
00:41:49,800 --> 00:41:51,480
THESE DISCUSSIONS.  IT IS ONE

991
00:41:51,480 --> 00:41:53,560
THING TO LECTURE A ONE WAY

992
00:41:53,560 --> 00:41:54,240
TRANSMISSION OF INFORMATION,

993
00:41:54,240 --> 00:41:55,880
THAT IS EASY ENOUGH TO DO WITH

994
00:41:55,880 --> 00:42:00,400
THIS FORMAT AND IT IS FANTASTIC

995
00:42:00,400 --> 00:42:02,120
BUT A LOT OF WHAT WE DO HERE

996
00:42:02,120 --> 00:42:03,160
REQUIRES BENEFITS FROM

997
00:42:03,160 --> 00:42:05,120
DISCUSSION, THAT'S VERY HARD TO

998
00:42:05,120 --> 00:42:07,720
DO WITH ONE PERSON IN A BOX WITH

999
00:42:07,720 --> 00:42:08,920
A GREEN THING AROUND THEM AT A

1000
00:42:08,920 --> 00:42:09,880
TIME.

1001
00:42:09,880 --> 00:42:12,040
>> THANKS, SAME,R. TIM.

1002
00:42:12,040 --> 00:42:14,000
>> I HAD A QUESTION
RELATED TO

1003
00:42:14,000 --> 00:42:16,640
THE WALTER'S TALK, IN ADDITION

1004
00:42:16,640 --> 00:42:19,360
TO JUST SIMPLY AGREEING WITH

1005
00:42:19,360 --> 00:42:20,520
SAMEER WITH RESPECT TO COUNCIL

1006
00:42:20,520 --> 00:42:22,200
MEETINGS AND VALUE OF IN PERSON

1007
00:42:22,200 --> 00:42:23,680
INTERACTION FOSTERING

1008
00:42:23,680 --> 00:42:25,040
DISCUSSION. MY QUESTION WAS MORE

1009
00:42:25,040 --> 00:42:27,200
I DON'T KNOW IF THIS IS THE

1010
00:42:27,200 --> 00:42:28,400
APPROPRIATE TIME SINCE IT WAS

1011
00:42:28,400 --> 00:42:30,240
WHAT WALTER SPENT HALF HOUR

1012
00:42:30,240 --> 00:42:33,200
TALKING ABOUT, THE DATA SHARING

1013
00:42:33,200 --> 00:42:35,840
INITIATIVE THAT STARTS IN 2023,

1014
00:42:35,840 --> 00:42:38,000
ONE THING THAT IS VALUABLE I CAN

1015
00:42:38,000 --> 00:42:39,520
TELL YOU NOW THE UNCLEAR FROM

1016
00:42:39,520 --> 00:42:42,800
USERS POINT OF VIEW, IS EXACTLY

1017
00:42:42,800 --> 00:42:44,480
WHAT LEVEL APPLIES -- IT IS ONE

1018
00:42:44,480 --> 00:42:46,120
THING I COULD PAY GOOD MONEY FOR

1019
00:42:46,120 --> 00:42:48,280
A CORE FACILITY TO GENERATE A

1020
00:42:48,280 --> 00:42:52,160
PROTEOME SEQUENCING THAT IS

1021
00:42:52,160 --> 00:42:54,000
READY TO SHIFT TO OPEN SOURCE

1022
00:42:54,000 --> 00:42:55,680
DATABASE BUT THAT IS THAT

1023
00:42:55,680 --> 00:42:56,720
CATEGORY. THERE IS A A LOT OF

1024
00:42:56,720 --> 00:42:57,440
OTHER THINGS THAT SUPPORT THE

1025
00:42:57,440 --> 00:42:59,400
WORK WE DO IN MY LAB THAT WILL

1026
00:42:59,400 --> 00:43:01,480
TAKE A HUGE AMOUNT OF ANNOTATION

1027
00:43:01,480 --> 00:43:03,600
TO MAKE IT USEFUL TO PUT INTO A

1028
00:43:03,600 --> 00:43:05,120
DATABASE SO IT WILL BE GREAT IF

1029
00:43:05,120 --> 00:43:07,000
THE PROGRAM OFFICERS COULD

1030
00:43:07,000 --> 00:43:08,440
SOMEHOW BEFORE DEADLINE HITS

1031
00:43:08,440 --> 00:43:10,880
MAKE IT CLEAR THE CATEGORIES AND

1032
00:43:10,880 --> 00:43:13,800
EXPECTATION OF WHAT THEY THINK

1033
00:43:13,800 --> 00:43:15,480
IS -- WHAT SHOULD BE SHARED,

1034
00:43:15,480 --> 00:43:16,920
WHAT THEY THINK IS THE RIGHT WAY

1035
00:43:16,920 --> 00:43:20,120
TO SHARE, WE ARE KIND OF GOING A

1036
00:43:20,120 --> 00:43:21,160
BIT LIKELY FOR STUFF, WHEN RIGOR

1037
00:43:21,160 --> 00:43:23,360
SHOWED UP AS CRITERIA FOR STUDY

1038
00:43:23,360 --> 00:43:24,440
SECTIONS, WE DIDN'T KNOW WHAT

1039
00:43:24,440 --> 00:43:26,480
THE STANDARDS WERE. SO IT

1040
00:43:26,480 --> 00:43:28,800
CHANGED EVERY STUDY SECTION. WE

1041
00:43:28,800 --> 00:43:30,880
HAD LIKE ON THE SITTING ON IT

1042
00:43:30,880 --> 00:43:32,360
JUST YEAH SOUNDS RIGOROUS TO ME.

1043
00:43:32,360 --> 00:43:34,880
BUT WE DIDN'T REALLY KNOW -- SO

1044
00:43:34,880 --> 00:43:36,840
I THINK SINCE THIS IS NEW AND IT

1045
00:43:36,840 --> 00:43:38,880
HAS SORT OF COSTS IMPLIED AS

1046
00:43:38,880 --> 00:43:40,640
NINA POINTED OUT FOR INTRAMURAL,

1047
00:43:40,640 --> 00:43:42,680
YOU DON'T KNOW HOW TO DO IT. BE

1048
00:43:42,680 --> 00:43:44,640
NICE IF THEY COULD WORK UP SOME

1049
00:43:44,640 --> 00:43:46,840
TEMPLATE FOR WHAT HOW WE SHOULD

1050
00:43:46,840 --> 00:43:48,960
THINK ABOUT IT. THANK YOU. 

1051
00:43:48,960 --> 00:43:55,960
>> THANKS, TIM. ALLAN.

1052
00:43:55,960 --> 00:43:57,240
>> MIGHT BE INTERESTED IN
HAVING

1053
00:43:57,240 --> 00:43:59,400
AT LEAST ONE MEETING IN PERSON A

1054
00:43:59,400 --> 00:44:00,880
YEAR, NOT SO MUCH -- DON'T TAKE

1055
00:44:00,880 --> 00:44:04,520
IT PERSONALLY TO SEE PEOPLE IN

1056
00:44:04,520 --> 00:44:05,800
HOLLYWOOD SQUARES BUT TO SEE THE

1057
00:44:05,800 --> 00:44:07,200
PEOPLE SITTING AROUND THE TABLE.

1058
00:44:07,200 --> 00:44:09,400
WE DON'T GET TO INTERACT WITH

1059
00:44:09,400 --> 00:44:10,920
THEM AND A LOT OF INFORMATION

1060
00:44:10,920 --> 00:44:12,400
CAN BE GATHERED NOT ONLY JUST TO

1061
00:44:12,400 --> 00:44:13,880
GET TO KNOW THEM BECAUSE

1062
00:44:13,880 --> 00:44:15,600
SOMETIMES WE DEAL WITH THEM BY

1063
00:44:15,600 --> 00:44:17,080
EMAIL BUT TO ACTUALLY WHEN THERE

1064
00:44:17,080 --> 00:44:18,560
IS A FREE TIME TO TALK ABOUT

1065
00:44:18,560 --> 00:44:19,960
SOME OF THE QUESTIONS THAT ARE

1066
00:44:19,960 --> 00:44:22,200
RELEVANT TO COUNCIL DECISIONS,

1067
00:44:22,200 --> 00:44:23,280
WE JUST DON'T HAVE ANY

1068
00:44:23,280 --> 00:44:24,920
INTERACTION WITH THEM AT ALL

1069
00:44:24,920 --> 00:44:26,080
WHEN IT IS ONLY A VIRTUAL

1070
00:44:26,080 --> 00:44:27,280
MEETING WHERE I SEE PEOPLE ARE

1071
00:44:27,280 --> 00:44:31,040
SITTING AROUND THE TABLE.

1072
00:44:31,040 --> 00:44:33,320
>> BY THE WAY TIM IN TERMS
OF

1073
00:44:33,320 --> 00:44:34,680
YOUR POINT, WE HAVE AN INTERNAL

1074
00:44:34,680 --> 00:44:37,840
WORKING GROUP RUNNING FOR SOME

1075
00:44:37,840 --> 00:44:39,760
TIME LED BY LYNN JAKEMAN

1076
00:44:39,760 --> 00:44:40,960
ADDRESSING ISSUES OF DATA

1077
00:44:40,960 --> 00:44:44,040
SHARING AMONG OTHERS. YOUR POINT

1078
00:44:44,040 --> 00:44:45,960
IS THAT WE HEARD LOUD AND CLEAR.

1079
00:44:45,960 --> 00:44:47,560
LOUISE. 

1080
00:44:47,560 --> 00:44:51,160
>> I AGREE WITH BOTH,
THERE'S

1081
00:44:51,160 --> 00:44:52,680
SOMETHING MISSING WITHOUT FACE

1082
00:44:52,680 --> 00:44:54,960
TO FACE INTERACTIONS BUT I ALSO

1083
00:44:54,960 --> 00:44:57,240
RECOGNIZE DUE TO PEOPLE'S

1084
00:44:57,240 --> 00:44:59,600
SCHEDULES AND THE COST

1085
00:44:59,600 --> 00:45:02,200
ASSOCIATED WITH ALWAYS DOING IT

1086
00:45:02,200 --> 00:45:06,320
IN PERSON, THERE IS PROBABLY

1087
00:45:06,320 --> 00:45:08,960
MAYBE WIGGLE ROOM TO ALTERNATE

1088
00:45:08,960 --> 00:45:11,080
WHERE -- AGAIN, IF THERE IS AN

1089
00:45:11,080 --> 00:45:13,000
IMPORTANT HEME IN COUNCIL YOU

1090
00:45:13,000 --> 00:45:15,240
MISS THIS IN PERSON INTERACTION

1091
00:45:15,240 --> 00:45:16,760
MEETING WITH COLLEAGUES,

1092
00:45:16,760 --> 00:45:18,640
THINKING OF THINGS. I THINK A

1093
00:45:18,640 --> 00:45:20,280
LOT OF THE OFF HOURS DISCUSSIONS

1094
00:45:20,280 --> 00:45:23,280
ARE VERY HELPFUL TOO. BUT IT IS

1095
00:45:23,280 --> 00:45:25,240
COSTLY AND PERHAPS THOSE COSTS

1096
00:45:25,240 --> 00:45:27,200
COULD BE FUNNELED INTO SOMETHING

1097
00:45:27,200 --> 00:45:29,560
MORE USEFUL AS I THINK SOMEONE

1098
00:45:29,560 --> 00:45:31,160
ELSE MENTIONED. BECAUSE IT WOULD

1099
00:45:31,160 --> 00:45:34,200
BE A MAJOR COST SAVINGS IF WE

1100
00:45:34,200 --> 00:45:36,160
DID WANT IT ONE LIVE, ONE

1101
00:45:36,160 --> 00:45:38,440
REMOTE, ONE LIVE ONE REMOTE. 

1102
00:45:38,440 --> 00:45:40,440
>> THERE IS A NUMBER OF

1103
00:45:40,440 --> 00:45:41,480
INSTITUTESES THAT ARE THINKING

1104
00:45:41,480 --> 00:45:42,800
ABOUT HAVING ONE IN PERSON

1105
00:45:42,800 --> 00:45:46,040
MEETING A YEAR. ALTERNATING IS

1106
00:45:46,040 --> 00:45:48,520
ANOTHER POSSIBILITY. COUNCIL

1107
00:45:48,520 --> 00:45:49,320
MEMBERS HAVE TOLD ME THEY MISSED

1108
00:45:49,320 --> 00:45:51,840
COUNCIL DINNER WHICH WAS A FORUM

1109
00:45:51,840 --> 00:45:53,560
WHERE EVERYBODY SHARED

1110
00:45:53,560 --> 00:45:57,680
INFORMATION AND SHARED OTHER

1111
00:45:57,680 --> 00:46:02,320
THINGS AS WELL.

1112
00:46:02,320 --> 00:46:04,720
>> I REALLY MAKE THE CASE
THAT

1113
00:46:04,720 --> 00:46:07,440
THE IN PERSON MEETINGS ARE WORTH

1114
00:46:07,440 --> 00:46:10,440
THE EXPENSE. I THINK IT IS

1115
00:46:10,440 --> 00:46:12,440
BUILDS COMMUNITY AMONG THE

1116
00:46:12,440 --> 00:46:14,840
COUNCIL, HELPS US WORK TOGETHER

1117
00:46:14,840 --> 00:46:16,560
BETTER AS A TEAM WHEN WE CAN BE

1118
00:46:16,560 --> 00:46:19,680
TOGETHER. I THINK ALSO BEING

1119
00:46:19,680 --> 00:46:24,000
ABLE TO SEE THE NINDS STAFF,

1120
00:46:24,000 --> 00:46:26,720
DINNER BOB MENTIONED I THINK IS

1121
00:46:26,720 --> 00:46:28,360
REALLY IMPORTANT. SO HAVING DONE

1122
00:46:28,360 --> 00:46:32,840
BOTH IN PERSON AND REMOTE, I

1123
00:46:32,840 --> 00:46:35,320
REALLY WOULD URGE US TO GO BACK

1124
00:46:35,320 --> 00:46:36,760
TO THE IN PERSON. WE CERTAINLY

1125
00:46:36,760 --> 00:46:39,800
HAD THE TECHNOLOGY TO DO REMOTE

1126
00:46:39,800 --> 00:46:41,240
BEFORE THE PANDEMIC AND IT IS

1127
00:46:41,240 --> 00:46:44,840
OBVIOUSLY DECISION WAS MADE TO

1128
00:46:44,840 --> 00:46:47,000
NOT DO THAT. I WOULD URGE AT

1129
00:46:47,000 --> 00:46:49,680
LEAST TO GO BACK IN PERSON AND

1130
00:46:49,680 --> 00:46:51,920
GIVE IT A TRY.

1131
00:46:51,920 --> 00:46:56,440
>> THANKS A LOT, ED. KEN.

1132
00:46:56,440 --> 00:46:58,640
>> THANKS. SO NOT
SURPRISINGLY

1133
00:46:58,640 --> 00:47:03,040
I'M ECHOING WHAT YOU HEARD

1134
00:47:03,040 --> 00:47:05,920
BEFORE, I THINK THE ADDITIONAL

1135
00:47:05,920 --> 00:47:07,520
PERSPECTIVE THAT I WOULD SHARE

1136
00:47:07,520 --> 00:47:09,800
IS IF THERE IS A SENSE THAT WE

1137
00:47:09,800 --> 00:47:12,160
CAN SAVE ON TRAVEL AND SAVE ON

1138
00:47:12,160 --> 00:47:13,440
EXPENSES AND THINGS LIKE THAT,

1139
00:47:13,440 --> 00:47:19,520
BY HAVING ONE VIRTUAL MEETING, I

1140
00:47:19,520 --> 00:47:21,480
WOULD SUGGEST THAT THINKING

1141
00:47:21,480 --> 00:47:24,360
AROUND WHAT TOPICS GET DISCUSSED

1142
00:47:24,360 --> 00:47:26,960
IN THE FACE TO FACE MEETING IS

1143
00:47:26,960 --> 00:47:29,200
REALLY IMPORTANT. SO IF YOU --

1144
00:47:29,200 --> 00:47:32,120
IF NINDS IS UNDERGOING SOME

1145
00:47:32,120 --> 00:47:33,640
STRATEGIC CHANGES, THERE'S SOME

1146
00:47:33,640 --> 00:47:34,720
IMPORTANT STRATEGIC INITIATIVES

1147
00:47:34,720 --> 00:47:36,400
COMING OUT FROM CONGRESS THAT

1148
00:47:36,400 --> 00:47:38,440
NEED TO BE DISCUSSED OR PUT ON

1149
00:47:38,440 --> 00:47:43,720
THE TABLE, INSTITUTE REVIEWS,

1150
00:47:43,720 --> 00:47:45,120
REALLY WEIGHTY TOPICS WHERE YOU

1151
00:47:45,120 --> 00:47:47,440
WANT TO HEAR FROM EVERY MEMBER

1152
00:47:47,440 --> 00:47:48,760
OF YOUR COUNCIL, THAT IS A FACE

1153
00:47:48,760 --> 00:47:52,440
TO FACE MEETING. BECAUSE WE ARE

1154
00:47:52,440 --> 00:47:53,520
ALL ENGAGED BUT WHEN YOU ARE IN

1155
00:47:53,520 --> 00:47:56,840
A VIRTUAL MEETING FOR THREE

1156
00:47:56,840 --> 00:47:57,960
HOURS, FOUR HOURS, YOUR

1157
00:47:57,960 --> 00:47:59,640
CONCENTRATION IS NOT GOING TO BE

1158
00:47:59,640 --> 00:48:01,400
THERE. IT IS MUCH MORE THERE,

1159
00:48:01,400 --> 00:48:03,640
MUCH MORE ANIMATED YOU ARE MORE

1160
00:48:03,640 --> 00:48:05,200
LIKELY TO GET MORE PEOPLE REALLY

1161
00:48:05,200 --> 00:48:06,520
THINK WHEN YOU ARE FACE TO FACE,

1162
00:48:06,520 --> 00:48:08,000
I THINK WHEN YOU ARE DEALING

1163
00:48:08,000 --> 00:48:10,800
WITH THOSE KINDS OF WEIGHTY

1164
00:48:10,800 --> 00:48:12,480
ISSUES THAT'S WHEN YOU WANT TO

1165
00:48:12,480 --> 00:48:13,160
HAVE FACE TO FACE.

1166
00:48:13,160 --> 00:48:14,840
>> THAT IS REALLY
INTERESTING

1167
00:48:14,840 --> 00:48:15,680
POINT THAT I HADN'T THOUGHT

1168
00:48:15,680 --> 00:48:20,280
ABOUT. TAILORING THE TOPICS TO

1169
00:48:20,280 --> 00:48:22,360
THE TYPE OF MEETING. THERE IS A

1170
00:48:22,360 --> 00:48:23,960
BUNCH OF COMMENTS IN THE CHAT,

1171
00:48:23,960 --> 00:48:26,640
GINA WAS TALKING ABOUT MONEY

1172
00:48:26,640 --> 00:48:29,520
COST SAVING AND ENVIRONMENTAL

1173
00:48:29,520 --> 00:48:30,760
HELPFUL NOT TO HAVE IN PERSON

1174
00:48:30,760 --> 00:48:34,120
MEETINGS. AND CHRIS WAS ALSO

1175
00:48:34,120 --> 00:48:37,360
AGREEING WITH THAT, SAYING I

1176
00:48:37,360 --> 00:48:39,480
WOULD LOVE TO KNOW HOW MUCH

1177
00:48:39,480 --> 00:48:40,600
MONEY SAVED BY VIRTUAL MEETINGS

1178
00:48:40,600 --> 00:48:42,320
AND HOW THAT MONEY WAS USED. THE

1179
00:48:42,320 --> 00:48:43,640
OTHER THING I WANT TO CLARIFY,

1180
00:48:43,640 --> 00:48:46,440
WHEN WE ARE TALKING HYBRID WE

1181
00:48:46,440 --> 00:48:48,680
ARE NOT TALKING ABOUT SOME

1182
00:48:48,680 --> 00:48:50,960
MEETINGS VIRTUAL AND SOME IN

1183
00:48:50,960 --> 00:48:52,960
PERSON. A HYBRID MEETING IS ONE

1184
00:48:52,960 --> 00:48:54,600
WHERE SOME PEOPLE ARE THERE IN

1185
00:48:54,600 --> 00:48:56,960
PERSON AND OTHERS ARE THERE ON

1186
00:48:56,960 --> 00:48:59,760
ZOOM. I ACTUALLY HAVE -- IN YOUR

1187
00:48:59,760 --> 00:49:00,840
COMMENTS, I HAVE A QUESTION FOR

1188
00:49:00,840 --> 00:49:02,200
YOU BECAUSE I'M NOT SURE HOW

1189
00:49:02,200 --> 00:49:06,000
WELL THAT MODEL WORKS. IS YOUR

1190
00:49:06,000 --> 00:49:12,040
HAND OUT -- YOU ARE MUTE MUTED.

1191
00:49:12,040 --> 00:49:13,560
>> COUPLE OF COMMENTS. ONE
I

1192
00:49:13,560 --> 00:49:16,720
TAUGHT A HYBRID CLASS, THIS PAST

1193
00:49:16,720 --> 00:49:20,320
SEMESTER, IT IS REALLY HARD TO

1194
00:49:20,320 --> 00:49:22,720
DO WELL AND I THINK PEOPLE WHO

1195
00:49:22,720 --> 00:49:26,480
ARE ONLINE JUST ARE NOT AS WELL

1196
00:49:26,480 --> 00:49:27,960
INTEGRATED. IT WAS WORSE THAN

1197
00:49:27,960 --> 00:49:29,760
ALL IN PERSON OR ALL ONLINE. I

1198
00:49:29,760 --> 00:49:31,360
THINK ALL ONLINE THE STUDENTS

1199
00:49:31,360 --> 00:49:34,680
FELT LIKE THEY WERE ALL ENGAGED,

1200
00:49:34,680 --> 00:49:36,640
ALL IN PERSON IS NOT ONLY

1201
00:49:36,640 --> 00:49:37,800
DIFFICULT FOR PERSON MODERATING

1202
00:49:37,800 --> 00:49:40,400
IT BUT IT HAS -- FIGURE OUT

1203
00:49:40,400 --> 00:49:42,400
GREAT SUCCESSFUL MODEL FOR THAT.

1204
00:49:42,400 --> 00:49:45,000
THE SECOND IS I THINK THAT'S

1205
00:49:45,000 --> 00:49:46,600
SPECIALLY FOR PARENTS WITH

1206
00:49:46,600 --> 00:49:47,960
CHILDREN LIKE ME FOR YOUNG

1207
00:49:47,960 --> 00:49:49,840
CHILDREN THAT THE VALUE OF

1208
00:49:49,840 --> 00:49:54,480
VIRTUAL AND BURDENS OF VIRTUAL

1209
00:49:54,480 --> 00:49:55,640
ENABLE GREATER PARTICIPATION IN

1210
00:49:55,640 --> 00:49:57,880
WAYS THAT PEOPLE WITH SMALLER OR

1211
00:49:57,880 --> 00:49:59,520
YOUNGER CHILDREN OR OLDER

1212
00:49:59,520 --> 00:50:00,400
CHILDREN, I DON'T KNOW WHAT THAT

1213
00:50:00,400 --> 00:50:03,600
IS LIKE YET, EXPERIENCE IN

1214
00:50:03,600 --> 00:50:06,440
TRAVELING AND I KNOW THAT THAT

1215
00:50:06,440 --> 00:50:08,600
TENDS TO SOMETIMES BE GENDER

1216
00:50:08,600 --> 00:50:09,680
DISTRIBUTION OF ROLES AND

1217
00:50:09,680 --> 00:50:11,800
BURDENS, SO I THINK A LOT OF

1218
00:50:11,800 --> 00:50:14,320
PEOPLE L ARE LOOKING AT THE

1219
00:50:14,320 --> 00:50:16,480
IMPACT OF DIFFERENT CAREGIVER

1220
00:50:16,480 --> 00:50:18,840
ROLES AND HOW VIRTUAL ENABLES

1221
00:50:18,840 --> 00:50:21,960
BETTER PARTICIPATION AND MY

1222
00:50:21,960 --> 00:50:24,440
PLAYING FIELD A BIT IN THAT WAY.

1223
00:50:24,440 --> 00:50:26,800
I THINK THAT WE ALL ARE GOING TO

1224
00:50:26,800 --> 00:50:28,880
FIGURE OUT WHAT ONLINE MEETINGS

1225
00:50:28,880 --> 00:50:31,560
LOOK LIKE, WHAT WE TRIED THE

1226
00:50:31,560 --> 00:50:33,160
PAST TWO YEARS WAS SHORTEN THEM

1227
00:50:33,160 --> 00:50:34,960
BUT LARGELY HAD TO BE SAME

1228
00:50:34,960 --> 00:50:36,000
EXPERIENCE WHAT IT WAS IN PERSON

1229
00:50:36,000 --> 00:50:39,640
AND THAT DOESN'T WORK. I THINK

1230
00:50:39,640 --> 00:50:41,000
IT IS THE WEIGHT OF THE FUTURE

1231
00:50:41,000 --> 00:50:42,640
IS TO EXPECT MORE ONLINE

1232
00:50:42,640 --> 00:50:45,000
MEETINGS BUT FIGURING OUT HOW TO

1233
00:50:45,000 --> 00:50:47,680
DO SO, THAT IT ISN'T PASSIVE

1234
00:50:47,680 --> 00:50:50,480
ENGAGEMENT IN WAYS THAT BREAKS

1235
00:50:50,480 --> 00:50:53,000
MEETINGS IN PERSON ENABLED THAT

1236
00:50:53,000 --> 00:50:54,480
MODEL TO WORK. THAT MODEL

1237
00:50:54,480 --> 00:50:57,320
DOESN'T WORK ONLINE. AS WE ALL

1238
00:50:57,320 --> 00:50:58,360
KNOW. THERE ARE MANY

1239
00:50:58,360 --> 00:51:01,560
DISTRACTIONSES AND DIFFICULTIES

1240
00:51:01,560 --> 00:51:03,000
HAVING WATER COOLER

1241
00:51:03,000 --> 00:51:03,600
CONVERSATIONS AND EVERYTHING

1242
00:51:03,600 --> 00:51:04,920
ELSE BUT I THINK IT MEANS THE

1243
00:51:04,920 --> 00:51:08,480
MORE WE START TO INNOVATE WITH

1244
00:51:08,480 --> 00:51:10,840
SHORTER MEETINGS, SPREAD OVER

1245
00:51:10,840 --> 00:51:12,560
MORE DAYS MORE INTERACTIVE

1246
00:51:12,560 --> 00:51:14,920
MEETINGS MORE BREAK OUT SESSIONS

1247
00:51:14,920 --> 00:51:16,720
MORE DIFFERENT MODELS WE WILL

1248
00:51:16,720 --> 00:51:18,920
GET BETTER AT IT BUT WE HAVE TO

1249
00:51:18,920 --> 00:51:21,040
GET BETTER AT IT FOR IT TO COME

1250
00:51:21,040 --> 00:51:21,840
CLOSE TO APPROXIMATE MATEING

1251
00:51:21,840 --> 00:51:23,560
WHAT THE IN PERSON EXPERIENCE OF

1252
00:51:23,560 --> 00:51:29,280
MEETINGS IS LIKE.

1253
00:51:29,280 --> 00:51:31,080
>> SOMEONE ASKED
MISDEMEANOR THE

1254
00:51:31,080 --> 00:51:32,640
CHAT, SURELY THIS HAS BEEN

1255
00:51:32,640 --> 00:51:34,120
STUDIED. THE ANSWER IS ALREADY

1256
00:51:34,120 --> 00:51:36,360
STUDIED TREMENDOUS EXTENT, WE

1257
00:51:36,360 --> 00:51:40,360
LOOK AT ALL KINDS OF PAPERS ONE

1258
00:51:40,360 --> 00:51:42,560
THAT WALTER SENT RECENTLY SEEMED

1259
00:51:42,560 --> 00:51:43,800
TO SUGGEST, THAT BRAINSTORMING

1260
00:51:43,800 --> 00:51:45,800
IS BETTER IN PERSON. THE OTHER

1261
00:51:45,800 --> 00:51:47,680
HAND THERE'S ALL KINDS OF

1262
00:51:47,680 --> 00:51:51,200
STUDIES THAT SHOW SITTING ALONE

1263
00:51:51,200 --> 00:51:53,160
COMING UP WITH IDEAS SO WHO

1264
00:51:53,160 --> 00:51:55,720
KNOWS HOW TO INTERPRET BUT ANY

1265
00:51:55,720 --> 00:51:57,240
CASE, IN PERSON MEETINGS

1266
00:51:57,240 --> 00:51:58,640
DEFINITELY ARE DIFFERENT AND A

1267
00:51:58,640 --> 00:52:00,800
LOT OF THINGS ARE BETTER. BUT

1268
00:52:00,800 --> 00:52:03,080
THERE IS ADVANTAGES TO -- I

1269
00:52:03,080 --> 00:52:03,760
GUESS THE CONSENSUS THAT SEEMS

1270
00:52:03,760 --> 00:52:05,960
TO BE EMERGING IN THE CHAT IS

1271
00:52:05,960 --> 00:52:08,880
THAT HYBRID MEETINGS ARE LOUSY. 

1272
00:52:08,880 --> 00:52:11,440
THAT THEY DON'T WORK. I SEE

1273
00:52:11,440 --> 00:52:15,120
HEADS NODDING UP AND DOWN. 

1274
00:52:15,120 --> 00:52:16,960
>> WALTER, DO YOU WANT ANY
MORE

1275
00:52:16,960 --> 00:52:18,880
FEEDBACK, DO YOU WANT TO SAY

1276
00:52:18,880 --> 00:52:21,600
ANYTHING ABOUT THIS? ON THAT

1277
00:52:21,600 --> 00:52:23,360
PARTICULAR TOPIC?

1278
00:52:23,360 --> 00:52:25,000
>> I THINK THE POSITION WE
HEARD

1279
00:52:25,000 --> 00:52:29,600
IS LET'S SEE IF WE GET SOME MORE

1280
00:52:29,600 --> 00:52:32,240
IDEAS OUT THERE PEOPLE PUT THEIR

1281
00:52:32,240 --> 00:52:35,280
OWN THOUGHT MS. THE CHAT. SO

1282
00:52:35,280 --> 00:52:36,880
SOUNDS LIKE WE DEFINITELY WANT

1283
00:52:36,880 --> 00:52:41,400
TO HAVE ONE IN PERSON MEETING.

1284
00:52:41,400 --> 00:52:43,920
QUESTION IS DO WE WANT TWO OR WE

1285
00:52:43,920 --> 00:52:47,360
GOOD WITH ONE? IT ALSO SOUNDS

1286
00:52:47,360 --> 00:52:50,960
LIKE WE DON'T WANT HYBRID BUT WE

1287
00:52:50,960 --> 00:52:51,800
SOME PEOPLE WOULD LIKE TO

1288
00:52:51,800 --> 00:52:57,520
ACTUALLY HAVE A VIRTUAL MEETING 

1289
00:52:57,520 --> 00:52:59,600
SO ONE OPTION MIGHT BE TWO IN

1290
00:52:59,600 --> 00:53:01,680
PERSONS AND ONE VIRTUAL OR ONE

1291
00:53:01,680 --> 00:53:04,160
IN PERSON TWO VIRTUALS. SO IF

1292
00:53:04,160 --> 00:53:10,360
YOU CAN PUT IN THE CHAT -- WE

1293
00:53:10,360 --> 00:53:12,280
ARE TALKING ABOUT YOU GUYS WE

1294
00:53:12,280 --> 00:53:13,360
ARE HAPPY TO DO WHATEVER YOU

1295
00:53:13,360 --> 00:53:15,920
THINK IS BEST, TRY SOMETHING

1296
00:53:15,920 --> 00:53:17,440
SOMETHING DIFFERENT LATER BUT

1297
00:53:17,440 --> 00:53:20,920
PUT IN THE CHAT WHAT YOU WOULD

1298
00:53:20,920 --> 00:53:21,840
THINK. SAVE THE CHAT.

1299
00:53:21,840 --> 00:53:23,880
>> VIRTUAL AT WINTERTIME
AND

1300
00:53:23,880 --> 00:53:25,640
NUMBER OF PEOPLE SAID THAT. I

1301
00:53:25,640 --> 00:53:30,360
THINK GINA'S HAND, ACTUAL HAND?

1302
00:53:30,360 --> 00:53:33,400
THAT IS WHAT I SAID. SHOJI IN

1303
00:53:33,400 --> 00:53:35,320
AND NINA, THEN WE NEED TO MOVE

1304
00:53:35,320 --> 00:53:35,480
ON.

1305
00:53:35,480 --> 00:53:38,040
>> HI, EVERYBODY. THANK
YOU,

1306
00:53:38,040 --> 00:53:40,640
ROBERT FOR TELLING US ABOUT THE

1307
00:53:40,640 --> 00:53:42,080
STUDIES THAT HAVE BEEN DONE. I

1308
00:53:42,080 --> 00:53:43,960
WANT TO THANK EVERYBODY FOR

1309
00:53:43,960 --> 00:53:46,520
THEIR GOOD THOUGHTS. NINA, I

1310
00:53:46,520 --> 00:53:48,280
HAVE ALSO TRIED TO TEACH A

1311
00:53:48,280 --> 00:53:50,720
HYBRID CLASS AND IT IS REALLY,

1312
00:53:50,720 --> 00:53:53,240
REALLY DIFFICULT. BUT WHEN YOU

1313
00:53:53,240 --> 00:53:55,560
DO IT WITH OTHER CO-TEACHERS IN

1314
00:53:55,560 --> 00:53:57,880
THE ROOM WHO CAN MONITOR THE

1315
00:53:57,880 --> 00:54:00,680
CHATS AND CALL ON PEOPLE ASKING

1316
00:54:00,680 --> 00:54:02,440
QUESTIONS, IT WORKS ACTUALLY

1317
00:54:02,440 --> 00:54:04,200
PRETTY WELL, ESPECIALLY IF

1318
00:54:04,200 --> 00:54:05,720
SOMEONE IS SICK AND HAS TO STAY

1319
00:54:05,720 --> 00:54:07,200
HOME, IT ALLOWS THEM TO BE PART

1320
00:54:07,200 --> 00:54:11,040
OF THE CLASS STILL AND HEAR IT

1321
00:54:11,040 --> 00:54:13,920
LIVE. I REALLY THINK ACTUALLY

1322
00:54:13,920 --> 00:54:16,360
HYBRID CAN WORK IF DONE

1323
00:54:16,360 --> 00:54:17,760
PROPERLY, IF DONE WITH LOTS OF

1324
00:54:17,760 --> 00:54:22,600
SUPPORT PEOPLE MONITORING THE

1325
00:54:22,600 --> 00:54:23,880
CHATS AND MAYBE WITH PROPER

1326
00:54:23,880 --> 00:54:25,480
KINDS OF MICROPHONES SPREAD

1327
00:54:25,480 --> 00:54:27,720
AROUND THE ROOM FOR THOSE WHO

1328
00:54:27,720 --> 00:54:32,480
WERE THERE IN PERSON SO THAT

1329
00:54:32,480 --> 00:54:35,000
THOSE LISTENING ONLINE CAN TUNE

1330
00:54:35,000 --> 00:54:37,000
IN TO VARIOUS MICROPHONES

1331
00:54:37,000 --> 00:54:38,880
PERHAPS IF THAT WORKS. THERE

1332
00:54:38,880 --> 00:54:41,080
MIGHT BE A THOUGHTFUL WAY TO

1333
00:54:41,080 --> 00:54:43,880
MAKE IT WORK WELL. I ALSO LIKE

1334
00:54:43,880 --> 00:54:45,760
THE IDEA OF MAYBE ONE IN PERSON

1335
00:54:45,760 --> 00:54:47,680
MEETING OR TWO IN PERSON

1336
00:54:47,680 --> 00:54:51,400
MEETINGS, AND THE REST VIRTUAL.

1337
00:54:51,400 --> 00:54:55,440
SO ANYWAY, IT IS A GOOD QUESTION

1338
00:54:55,440 --> 00:54:56,440
AND THERE ARE DEFINITELY PLUSES

1339
00:54:56,440 --> 00:54:58,120
AND MINUSES TO EVERYTHING. FOR

1340
00:54:58,120 --> 00:54:59,720
EXAMPLE, ONE OF THE MINUSES FOR

1341
00:54:59,720 --> 00:55:00,760
VIRTUAL MEETINGS IS THAT SOME

1342
00:55:00,760 --> 00:55:03,080
PEOPLE DON'T HAVE GOOD ACCESS TO

1343
00:55:03,080 --> 00:55:10,400
THE INTERNET AND/OR HAVE A NOISY

1344
00:55:10,400 --> 00:55:12,400
ENVIRONMENT WHICH TO ACCESS THE

1345
00:55:12,400 --> 00:55:14,440
INTERNET. ANYWAY, PLUSES AND

1346
00:55:14,440 --> 00:55:20,920
MINUS ON BOTH SIDES. 

1347
00:55:20,920 --> 00:55:24,320
>> TIM AND BROOK, CAN
SOMEONE

1348
00:55:24,320 --> 00:55:31,520
SAVE THE CHAT FROM THIS MEETING 

1349
00:55:31,520 --> 00:55:36,760
I WANT TOE STAY ON SCHEDULE, I

1350
00:55:36,760 --> 00:55:39,960
HAVE OPEN ACCESS. NEXT, ONCE A

1351
00:55:39,960 --> 00:55:42,160
YEAR WE ARE REQUIRED TO HAVE A

1352
00:55:42,160 --> 00:55:43,800
DISCUSSION OF WHAT IS GOING ON

1353
00:55:43,800 --> 00:55:45,840
IN OUR INTRAMURAL PROGRAM AND

1354
00:55:45,840 --> 00:55:50,760
NINA WHO IS THE -- NINA SCHOR

1355
00:55:50,760 --> 00:55:52,640
THE PRINCIPAL DEPUTY TREK TO OF

1356
00:55:52,640 --> 00:55:54,840
NINDS BUT HEAD OF INTRAMURAL

1357
00:55:54,840 --> 00:55:57,800
NOW, OBVIOUSLY VERY NOW, SHE'S

1358
00:55:57,800 --> 00:55:59,920
GOING TO DO THAT. NOT A GREAT

1359
00:55:59,920 --> 00:56:01,320
INTRODUCTION NINA, BUTLY TURN IT

1360
00:56:01,320 --> 00:56:03,120
TO YOU.

1361
00:56:03,120 --> 00:56:04,840
>> PRETTY FAMILIAR TO THIS
GROUP

1362
00:56:04,840 --> 00:56:06,920
AND AS ALWAYS GRATEFUL TO ALL OF

1363
00:56:06,920 --> 00:56:09,320
YOU NOR TUNING IN AND -- FOR

1364
00:56:09,320 --> 00:56:12,160
TUNING IN, WONDERFUL TO SEE YOU

1365
00:56:12,160 --> 00:56:13,520
EVEN IN ZOOM PLATFORM. I AM

1366
00:56:13,520 --> 00:56:16,160
GOING TO SHARE MY SCREEN AND DO

1367
00:56:16,160 --> 00:56:20,640
A LITTLE BIT OF REALLY VERY

1368
00:56:20,640 --> 00:56:23,400
BRIEF PRESENTATION ON THE

1369
00:56:23,400 --> 00:56:25,760
INTRAMURAL PROGRAM. I'M GOING TO

1370
00:56:25,760 --> 00:56:28,800
FOCUS ON WHAT IS OUR REALLY

1371
00:56:28,800 --> 00:56:31,920
CURRENTLY OUR MAJOR ACTIVITY

1372
00:56:31,920 --> 00:56:37,240
WHICH IS TO PUT IN PLACE NEW

1373
00:56:37,240 --> 00:56:40,560
LEADERSHIP FOR THE INTRAMURAL

1374
00:56:40,560 --> 00:56:43,800
PROGRAM. I'M GOING TO TALK ABOUT

1375
00:56:43,800 --> 00:56:45,680
WHAT I HAVE TERMED THE FOUR STEP

1376
00:56:45,680 --> 00:56:49,000
PROCESS FOR PREPARATION. WE

1377
00:56:49,000 --> 00:56:51,160
BEGAN BY TAKING STOCK OF WHAT IT

1378
00:56:51,160 --> 00:56:52,760
IS THAT WE HAVE AND THEN

1379
00:56:52,760 --> 00:56:54,360
THINKING OF WHAT IT IS THAT WE

1380
00:56:54,360 --> 00:56:57,240
WOULD LIKE TO DO GOING FORWARD

1381
00:56:57,240 --> 00:57:00,880
IN ORDER TO IDENTIFY THE RIGHT

1382
00:57:00,880 --> 00:57:03,600
LEADER FOR THAT. WE THEN

1383
00:57:03,600 --> 00:57:05,280
EMBARKED ON A SURGE, SOME OF YOU

1384
00:57:05,280 --> 00:57:10,320
WERE PART OF THAT. WE SET

1385
00:57:10,320 --> 00:57:12,800
EXPECTATIONS FOR OURSELVES OF

1386
00:57:12,800 --> 00:57:16,200
THE PEOPLE THAT WE INTERVIEWED

1387
00:57:16,200 --> 00:57:18,840
BUT WE ALSO TRIED VERY HARD, I

1388
00:57:18,840 --> 00:57:21,800
TRIED AS I TALKED TO FACULTY AND

1389
00:57:21,800 --> 00:57:25,560
TO TRAINEES, TO SET THEIR

1390
00:57:25,560 --> 00:57:27,160
EXPECTATIONS FOR A NEW PERSON

1391
00:57:27,160 --> 00:57:31,520
COMING ON BOARD AS A LEADER. AND

1392
00:57:31,520 --> 00:57:33,360
FOR THEIR ABILITY TO HAVE INPUT

1393
00:57:33,360 --> 00:57:36,920
INTO THAT PROCESS. REALLY, I SAW

1394
00:57:36,920 --> 00:57:43,640
PART OF MY JOB COMING AFTER

1395
00:57:43,640 --> 00:57:45,320
LORENA HAVING STEPPED DOWN

1396
00:57:45,320 --> 00:57:47,440
RELATIVELY SOON AFTER ASSUMING

1397
00:57:47,440 --> 00:57:49,880
THE POSITION. I SAW MY JOB AS

1398
00:57:49,880 --> 00:57:51,760
NOT JUST LOWERING THE

1399
00:57:51,760 --> 00:57:55,280
TEMPERATURE IN THE ROOM BUT ALSO

1400
00:57:55,280 --> 00:57:58,560
AS ENABLING OPTIMISM TO

1401
00:57:58,560 --> 00:58:04,280
REEMERGE. ONCE WE HAVE A NEW

1402
00:58:04,280 --> 00:58:06,440
DIRECTOR ON SITE, OUR JOB AS A

1403
00:58:06,440 --> 00:58:08,560
FACULTY IS GOING TO BE TO

1404
00:58:08,560 --> 00:58:13,200
FACILITATE THE SUCCESS OF THAT

1405
00:58:13,200 --> 00:58:16,600
INDIVIDUAL. FINALLY AS WE

1406
00:58:16,600 --> 00:58:17,960
INAUGURATE A NEW SCIENTIFIC

1407
00:58:17,960 --> 00:58:20,000
DIRECTOR, I THINK WE HAVE TO

1408
00:58:20,000 --> 00:58:24,160
BEGIN THE PROCESS OF DEVELOPING

1409
00:58:24,160 --> 00:58:27,840
LEADERSHIP ABILITIES IN OUR MORE

1410
00:58:27,840 --> 00:58:30,160
JUNIOR MEMBERS AND PLANNING FOR

1411
00:58:30,160 --> 00:58:34,880
WHAT SUCCESSION LOOKS LIKE.  

1412
00:58:34,880 --> 00:58:39,000
TAKING STOCK IN DREAMING DREAMS 

1413
00:58:39,000 --> 00:58:43,160
WE BEGAN WITH THIS GROUP LARGELY

1414
00:58:43,160 --> 00:58:44,160
KNOWS ALREADY WITH THE STRATEGIC

1415
00:58:44,160 --> 00:58:45,280
PLANNING PROCESS AND CAME UP

1416
00:58:45,280 --> 00:58:49,200
WITH THREE CORNERSTONES OF WHAT

1417
00:58:49,200 --> 00:58:51,800
WE HAD TO BUILD UPON IN THE

1418
00:58:51,800 --> 00:58:54,600
INTRAMURAL PROGRAM AS

1419
00:58:54,600 --> 00:58:56,760
COLLABORATION, COMMUNICATION,

1420
00:58:56,760 --> 00:58:59,320
AND EQUITY. WE DID A SPACE AUDIT

1421
00:58:59,320 --> 00:59:01,200
TO ACTUALLY BE ABLE TO SAY TO

1422
00:59:01,200 --> 00:59:04,520
PEOPLE TAKING A LOOK AT THE

1423
00:59:04,520 --> 00:59:05,200
POSITION THIS IS THE SPACE THAT

1424
00:59:05,200 --> 00:59:08,160
YOU HAVE AVAILABLE NOT ONLY FOR

1425
00:59:08,160 --> 00:59:11,000
YOUR OWN RESEARCH PROGRAM BUT

1426
00:59:11,000 --> 00:59:13,040
ESPECIALLY FOR GROWING THE

1427
00:59:13,040 --> 00:59:14,480
PROGRAM, ESPECIALLY FOR

1428
00:59:14,480 --> 00:59:17,880
RECRUITMENT AND REPLACEMENT OF

1429
00:59:17,880 --> 00:59:22,120
PEOPLE IN THE PROGRAM. WE MADE A

1430
00:59:22,120 --> 00:59:24,960
MAJOR EFFORT AND I HAVE TO

1431
00:59:24,960 --> 00:59:27,000
CREDIT LORENA ROLE WITH

1432
00:59:27,000 --> 00:59:31,080
INITIATING THIS AND GETTING TO

1433
00:59:31,080 --> 00:59:32,080
SALARY EQUITY AND ENSURING THAT

1434
00:59:32,080 --> 00:59:33,360
THAT IS MAINTAINED AS WE BRING

1435
00:59:33,360 --> 00:59:38,400
PEOPLE IN. WE AND EVERYBODY AT

1436
00:59:38,400 --> 00:59:42,000
NIH HAVE BEEN FOCUSED ON WORK

1437
00:59:42,000 --> 00:59:45,360
FORCE DIVERSIFICATION. THEN MY

1438
00:59:45,360 --> 00:59:49,200
JOB AGAIN AS THE OPTIMIST OF THE

1439
00:59:49,200 --> 00:59:51,560
ENTERPRISE WAS TO ENABLE PEOPLE

1440
00:59:51,560 --> 00:59:53,720
TO DREAM BEYOND WHAT WE ARE

1441
00:59:53,720 --> 00:59:55,960
RIGHT NOW. WHAT DO WE WANT TO BE

1442
00:59:55,960 --> 00:59:57,880
THAT WE AREN'T RIGHT NOW. AND

1443
00:59:57,880 --> 01:00:01,520
WHAT DO WE NEED OPERATIONALLY TO

1444
01:00:01,520 --> 01:00:04,000
BEGIN THE PROCESS OF ACQUIRING

1445
01:00:04,000 --> 01:00:08,200
THAT AND ACHIEVING THA THAT. WEE

1446
01:00:08,200 --> 01:00:10,280
FORMED IN THE INTEREST OF

1447
01:00:10,280 --> 01:00:12,760
COLLABORATION AND COMMUNICATION

1448
01:00:12,760 --> 01:00:15,600
MANY GROUPS THAT DID NOT EXIST

1449
01:00:15,600 --> 01:00:18,720
BEFORE AND MANY VENUES INFORMED

1450
01:00:18,720 --> 01:00:22,480
AND ENABLED I THINK IN PART BY

1451
01:00:22,480 --> 01:00:24,760
ZOOM THAT DIDN'T EXIST BEFORE,

1452
01:00:24,760 --> 01:00:27,520
MY FAVORITE IS THE PORTER

1453
01:00:27,520 --> 01:00:29,240
NEUROSCIENCE BOOK CLUB THAT

1454
01:00:29,240 --> 01:00:31,560
PICKS EVERY QUARTER A DIFFERENT,

1455
01:00:31,560 --> 01:00:33,880
PORTER IS THE NAME OF THE

1456
01:00:33,880 --> 01:00:34,960
BUILDING WHICH OUR NEUROSCIENCE

1457
01:00:34,960 --> 01:00:38,360
COMMUNITY IS HOUSED. AND WE

1458
01:00:38,360 --> 01:00:39,920
CHOOSE A BOOK EVERY QUARTER AND

1459
01:00:39,920 --> 01:00:41,600
IT IS OFTEN A SCIENCE FICTION

1460
01:00:41,600 --> 01:00:44,160
BOOK OR A BOOK ABOUT CLIMATE

1461
01:00:44,160 --> 01:00:48,000
CHANGE OR BOOK ABOUT THE PEOPLE

1462
01:00:48,000 --> 01:00:51,680
OF THE HISTORY OF NEUROSCIENCE

1463
01:00:51,680 --> 01:00:53,080
AND EVERYBODY READS THE SAME

1464
01:00:53,080 --> 01:00:57,040
BOOK AND HAS A VERY ROBUST

1465
01:00:57,040 --> 01:00:58,880
DISCUSSION. BUT WE ALSO HAVE

1466
01:00:58,880 --> 01:01:00,200
AFFINITY GROUPS AND SPECIAL

1467
01:01:00,200 --> 01:01:02,600
INTEREST GROUPS THAT DIDN'T

1468
01:01:02,600 --> 01:01:04,520
EXIST BEFORE. A PROGRAM FOR

1469
01:01:04,520 --> 01:01:06,120
CAREER ADVANCEMENT THAT YOU HAVE

1470
01:01:06,120 --> 01:01:10,200
HEARD ABOUT IN THE PAST CALLED

1471
01:01:10,200 --> 01:01:14,200
BEACON FOR OUR NURSES. AND A

1472
01:01:14,200 --> 01:01:17,360
CORE IDEALS PROGRAM THAT REALLY

1473
01:01:17,360 --> 01:01:21,240
FOCUSES ON HOW DO WE ENSURE

1474
01:01:21,240 --> 01:01:24,520
INCREASING CIVILITY COLLEGIALITY

1475
01:01:24,520 --> 01:01:30,800
AMONG THE PEOPLE THAT ARE NEU

1476
01:01:30,800 --> 01:01:33,720
NEUROSCIENCE AT NINDS. WE HAVE

1477
01:01:33,720 --> 01:01:35,560
MUCH TO BE PROUD OF AND TO

1478
01:01:35,560 --> 01:01:37,920
SHOWCASE IN FRONT OF CANDIDATES

1479
01:01:37,920 --> 01:01:41,120
THAT WE RECRUIT FOR THE NEXT

1480
01:01:41,120 --> 01:01:47,560
SCIENTIFIC DIRECTOR. I WANT TO

1481
01:01:47,560 --> 01:01:52,680
LET YOU KNOW OUR OWN ANTONINA

1482
01:01:52,680 --> 01:02:00,240
ROLL MECAK WON THE AWARD OF

1483
01:02:00,240 --> 01:02:01,480
BIOCHEMICAL SOCIETY. SHE WORKS

1484
01:02:01,480 --> 01:02:03,840
ON TUBULIN CODE, THE WAY IN

1485
01:02:03,840 --> 01:02:06,480
WHICH TUBULIN POST SYNTHETIC

1486
01:02:06,480 --> 01:02:07,760
MODIFICATION ACTUALLY SHAPES

1487
01:02:07,760 --> 01:02:14,440
WHAT GOES ON IN THE CELL. WE

1488
01:02:14,440 --> 01:02:17,480
HAVE HAD MANY ON HAIR ELECTIONS

1489
01:02:17,480 --> 01:02:21,120
TO MEMBERSHIPS THIS YEAR BOTH

1490
01:02:21,120 --> 01:02:23,080
AAAS AND AMERICAN SOCIETY FOR

1491
01:02:23,080 --> 01:02:25,200
CLINICAL INVESTIGATION. AMONG

1492
01:02:25,200 --> 01:02:27,520
THE CLINICS FOR THE ASSOCIATION

1493
01:02:27,520 --> 01:02:32,440
OF AMERICAN PHYSICIANS. AND

1494
01:02:32,440 --> 01:02:36,840
DANNY WRIGHTS ELECTION TO HENRY

1495
01:02:36,840 --> 01:02:38,400
CONKEL SOCIETY FOR IMMUNONOLOGY.

1496
01:02:38,400 --> 01:02:41,520
AGAIN, A GREAT DEAL OF PRIDE IN

1497
01:02:41,520 --> 01:02:44,080
WHAT WE BUILT TO DATE. THE

1498
01:02:44,080 --> 01:02:46,040
EXAMPLE OF THAT AND SOMETHING WE

1499
01:02:46,040 --> 01:02:48,560
HOLD UP TO SOME OF OUR YOUNGEST

1500
01:02:48,560 --> 01:02:49,680
MEMBERS IS THE FACT THAT THIS

1501
01:02:49,680 --> 01:02:53,560
YEAR WE HAVE A NEW SCIENTIST

1502
01:02:53,560 --> 01:02:57,280
EMERITUS AND TWO INDIVIDUALS WHO

1503
01:02:57,280 --> 01:03:06,000
GAVE VALEDICTORY PRESENTATIONS,

1504
01:03:06,000 --> 01:03:07,880
JEFF SMITH AND MARK HALLETT. 

1505
01:03:07,880 --> 01:03:10,280
THIS WAS THE BSC PRESENTATION

1506
01:03:10,280 --> 01:03:12,760
THAT REQUIRED NO CRITIQUE BUT

1507
01:03:12,760 --> 01:03:14,200
GAVE PEOPLE RETIRING A CHANCE

1508
01:03:14,200 --> 01:03:18,320
FOR A VICTORY LAP AROUND THE

1509
01:03:18,320 --> 01:03:22,720
STADIUM AND JUST REALLY

1510
01:03:22,720 --> 01:03:26,960
SPECTACULAR TALKS ABOUT NOT JUST

1511
01:03:26,960 --> 01:03:30,360
STUDIES IN SCIENCE BUT CAREERS

1512
01:03:30,360 --> 01:03:32,520
IN SCIENCE AND LIVES DEVOTED TO

1513
01:03:32,520 --> 01:03:36,160
SCIENCE, THAT REALLY STOOD AS AN

1514
01:03:36,160 --> 01:03:37,960
EMBLEM TO THOSE IN OUR GROUP

1515
01:03:37,960 --> 01:03:40,480
THAT ARE JUST STARTING OUT THEIR

1516
01:03:40,480 --> 01:03:44,080
CAREERS.  SO THEN WE EMBARKED

1517
01:03:44,080 --> 01:03:46,480
UPON A SEARCH, AS I SAY, SOME OF

1518
01:03:46,480 --> 01:03:47,240
YOU WERE INVOLVED IN THAT

1519
01:03:47,240 --> 01:03:51,960
PROCESS.  WE HAD AN INCREDIBLE

1520
01:03:51,960 --> 01:03:54,560
COMMITTEE. I AT EVERY STEP OF

1521
01:03:54,560 --> 01:03:57,480
THE PROCESS SAW IT AS MY

1522
01:03:57,480 --> 01:04:03,000
BUSINESS TO KEEP THE MEMBERS OF

1523
01:04:03,000 --> 01:04:06,000
THE NINDS INTRAMURAL RESEARCH

1524
01:04:06,000 --> 01:04:08,040
PROGRAM ENGAGED AND INFORMED TO

1525
01:04:08,040 --> 01:04:10,200
THE DEGREE THAT IT WAS

1526
01:04:10,200 --> 01:04:12,880
APPROPRIATE TO DO SO WITHOUT

1527
01:04:12,880 --> 01:04:14,920
DIVULGING ANYTHING THAT SHOULD

1528
01:04:14,920 --> 01:04:17,800
HAVE BEEN KEPT QUIET AND

1529
01:04:17,800 --> 01:04:19,960
CONFIDENTIAL FROM THE

1530
01:04:19,960 --> 01:04:22,400
CANDIDATES. IT IS A LITTLE BIT

1531
01:04:22,400 --> 01:04:24,400
OF A TIGHT ROPE WALK BUT THOUGHT

1532
01:04:24,400 --> 01:04:26,720
IT CRITICALLY IMPORTANT THAT THE

1533
01:04:26,720 --> 01:04:29,360
MEMBERS OF OUR COMMUNITY FEEL

1534
01:04:29,360 --> 01:04:32,680
ENGAGED AND INVOLVED AND

1535
01:04:32,680 --> 01:04:36,680
INFORMED FROM MINUTE ONE. WE

1536
01:04:36,680 --> 01:04:41,840
REACHED OUT BY EMAIL, BY PHONE,

1537
01:04:41,840 --> 01:04:44,640
BY SKYPE BY C WEEKEND, TO A

1538
01:04:44,640 --> 01:04:46,520
VERY, VERY LARGE POOL OF

1539
01:04:46,520 --> 01:04:48,600
POTENTIAL APPLICANTS AND

1540
01:04:48,600 --> 01:04:51,760
INDIVIDUALS THAT MIGHT INFORM US

1541
01:04:51,760 --> 01:04:55,320
OF POTENTIAL APPLICANTS. YOU CAN

1542
01:04:55,320 --> 01:04:57,520
SEE FROM THE TABLE ON YOUR LEFT,

1543
01:04:57,520 --> 01:04:59,600
IT WAS A RELATIVELY DIVERSE

1544
01:04:59,600 --> 01:05:03,880
GROUP THAT WE REACHED OUT TO.

1545
01:05:03,880 --> 01:05:05,840
AND ALMOST AS DIVERSE A GROUP

1546
01:05:05,840 --> 01:05:10,160
THAT APPLIED FOR THE POSITION. I

1547
01:05:10,160 --> 01:05:11,600
THINK LAST COUNT WE HAD 27

1548
01:05:11,600 --> 01:05:13,840
APPROXIMATE MR. I CAN'T FOR THIS

1549
01:05:13,840 --> 01:05:15,560
ONE POSITION. THEY WERE

1550
01:05:15,560 --> 01:05:19,720
Ph.D.s, M.D.s, MD

1551
01:05:19,720 --> 01:05:22,960
Ph.D.s AND VETERINARIANS. WE

1552
01:05:22,960 --> 01:05:26,320
FELT VERY, VERY GOOD ABOUT THE

1553
01:05:26,320 --> 01:05:29,520
DIVERSITY OF THIS GROUP IN EVERY

1554
01:05:29,520 --> 01:05:31,920
SENSE OF THE WORD. WE REALLY

1555
01:05:31,920 --> 01:05:34,000
CAST A VERY HIGH BAR FOR THE

1556
01:05:34,000 --> 01:05:36,880
QUALITY OF THESE APPLICANTS BUT

1557
01:05:36,880 --> 01:05:39,240
SAID THAT WE SHOULD CAST THE NET

1558
01:05:39,240 --> 01:05:41,560
VERY, VERY WIDELY FOR THE

1559
01:05:41,560 --> 01:05:44,360
SPECIFICS OF THEIR INTEREST IN

1560
01:05:44,360 --> 01:05:46,920
NEUROSCIENCE AND WHERE THEY CAME

1561
01:05:46,920 --> 01:05:50,280
FROM, WHO THEY REPRESENTED AS

1562
01:05:50,280 --> 01:05:58,000
CONSTITUENCIES. WE FELT VERY

1563
01:05:58,000 --> 01:05:59,800
IMPORTANT THAT AMONG NOT ONLY

1564
01:05:59,800 --> 01:06:03,080
THE APPLICANTS BUT AMONG THOSE

1565
01:06:03,080 --> 01:06:04,760
WHO BECAME FINALISTS AFTER A

1566
01:06:04,760 --> 01:06:08,240
FIRST ROUND OF INTERVIEWS, WE

1567
01:06:08,240 --> 01:06:09,960
INCLUDED MEN AND WOMEN. WE

1568
01:06:09,960 --> 01:06:12,800
INCLUDED M.D.s, Ph.D.s AND

1569
01:06:12,800 --> 01:06:16,360
M.D. Ph.D.s. THEIR INTEREST

1570
01:06:16,360 --> 01:06:21,320
RAN THE GAMUT OF NEUROSCIENCE

1571
01:06:21,320 --> 01:06:23,680
AND WHAT HELD THEM TOGETHER AS A

1572
01:06:23,680 --> 01:06:26,040
GROUP OF FINALISTS IS THAT EVERY

1573
01:06:26,040 --> 01:06:28,680
SINGLE ONE OF THEM HAS

1574
01:06:28,680 --> 01:06:31,080
LEADERSHIP EXPERIENCE, HAS HIGH,

1575
01:06:31,080 --> 01:06:33,880
HIGH QUALITY AND HIGH VISIBILITY

1576
01:06:33,880 --> 01:06:35,880
SCIENCE. THEY ARE ALL INTERESTED

1577
01:06:35,880 --> 01:06:38,280
IN TRAINING AND MENTORING AND

1578
01:06:38,280 --> 01:06:41,560
THEY ARE ALL DEDICATED TO

1579
01:06:41,560 --> 01:06:43,760
DIVERSITY EQUITY INCLUSION AND

1580
01:06:43,760 --> 01:06:47,200
ACCESS IN THE WORK FORCE. WE ARE

1581
01:06:47,200 --> 01:06:50,600
NOW IN THE MIDDLE OF HAVING THE

1582
01:06:50,600 --> 01:06:53,640
FINALISTS COME THROUGH IN ACTUAL

1583
01:06:53,640 --> 01:06:55,320
IN PERSON PHYSICAL VISITS. AND

1584
01:06:55,320 --> 01:06:58,360
MEET WITH JUNIOR FACULTY

1585
01:06:58,360 --> 01:07:00,280
TRAINEES, SEEN YOUR FACULTY AND

1586
01:07:00,280 --> 01:07:03,480
LAB AND OFFICE STAFF. REALLY

1587
01:07:03,480 --> 01:07:08,480
GIVING THEM A 360-DEGREE VIEW OF

1588
01:07:08,480 --> 01:07:11,920
WHO WE ARE AND GIVING OUR PEOPLE

1589
01:07:11,920 --> 01:07:13,760
A VIEW FROM EACH OF THEIR

1590
01:07:13,760 --> 01:07:15,760
VANTAGE POINTS OF THESE

1591
01:07:15,760 --> 01:07:17,200
CANDIDATES. AS I SAID, WE ARE IN

1592
01:07:17,200 --> 01:07:23,640
THE MIDDLE OF THE VISITS OF OUR

1593
01:07:23,640 --> 01:07:27,320
FINALISTS. ONCE WALTER WHO IS

1594
01:07:27,320 --> 01:07:28,800
THE DECIDING OFFICIAL DECIDES

1595
01:07:28,800 --> 01:07:31,600
WITH A VERY, VERY BROAD CROSS

1596
01:07:31,600 --> 01:07:36,920
SECTION OF INPUT, WHO IT IS THAT

1597
01:07:36,920 --> 01:07:40,760
IS THE DECISIONEE AND ONCE THAT

1598
01:07:40,760 --> 01:07:42,280
INDIVIDUAL SENSE THE POSITION, I

1599
01:07:42,280 --> 01:07:45,120
THINK THAT IS WHERE WE ALL AS A

1600
01:07:45,120 --> 01:07:48,360
COMMUNITY START FACILITATING

1601
01:07:48,360 --> 01:07:49,720
THAT INDIVIDUAL'S SUCCESS. I

1602
01:07:49,720 --> 01:07:53,560
WANT TO POINT OUT SEVERAL THINGS

1603
01:07:53,560 --> 01:07:56,480
THAT I THIS I EVOLVED LARGELY

1604
01:07:56,480 --> 01:07:58,080
THROUGH LORENA'S ADMINISTRATION

1605
01:07:58,080 --> 01:08:00,920
TO HELP ENSURE THAT PERSON'S

1606
01:08:00,920 --> 01:08:04,160
SUCCESS. THAT INCLUDES THE

1607
01:08:04,160 --> 01:08:06,360
INCREDIBLE OFFICE OF THE

1608
01:08:06,360 --> 01:08:07,880
SCIENTIFIC DIRECTOR STAFF THAT

1609
01:08:07,880 --> 01:08:11,480
WILL PROVIDE CONTINUITY,

1610
01:08:11,480 --> 01:08:13,360
COMPETENCY AND AUTHORITY THAT

1611
01:08:13,360 --> 01:08:15,720
TAKES SOME OF THE BOILERPLATE

1612
01:08:15,720 --> 01:08:19,160
THINGS OFF OF THE PLATE DIRECTLY

1613
01:08:19,160 --> 01:08:21,400
OF THE SCIENTIFIC DIRECTOR. WE

1614
01:08:21,400 --> 01:08:24,560
NOW HAVE A STANDARD OPERATING

1615
01:08:24,560 --> 01:08:26,360
PROCEDURES MANUAL FOR THESE

1616
01:08:26,360 --> 01:08:28,800
BOILERPLATE THINGS THAT WILL

1617
01:08:28,800 --> 01:08:31,800
ORIENT EVERYBODY VERY QUICKLY

1618
01:08:31,800 --> 01:08:33,680
AND STANDARDIZE THINGS. I THINK

1619
01:08:33,680 --> 01:08:38,640
ALL OF US WHO ARE INTRAMURAL

1620
01:08:38,640 --> 01:08:40,320
LEADERS OR WHO HAVE BEEN

1621
01:08:40,320 --> 01:08:42,080
SCIENTIFIC DIRECTORS IN THE PAST

1622
01:08:42,080 --> 01:08:44,800
HAVE A DUTY TO COACH AND ADVISE

1623
01:08:44,800 --> 01:08:48,280
BUT TO STAND BACK ENOUGH THAT

1624
01:08:48,280 --> 01:08:50,880
THE NEW INDIVIDUAL WILL HAVE

1625
01:08:50,880 --> 01:08:52,960
THEIR OWN PERIMETER ON THE

1626
01:08:52,960 --> 01:08:55,520
PROGRAM. I THINK WE ALL HAVE TO

1627
01:08:55,520 --> 01:09:00,320
BE MINDFUL OF THE UNIQUENESS OF

1628
01:09:00,320 --> 01:09:02,480
THE RELATIONSHIP AND POTENTIAL

1629
01:09:02,480 --> 01:09:04,880
FOR INTERACTION BETWEEN BASIC

1630
01:09:04,880 --> 01:09:06,960
AND CLINICAL NEUROSCIENCE ON THE

1631
01:09:06,960 --> 01:09:10,000
NIH CAMPUS. I THINK THAT WILL BE

1632
01:09:10,000 --> 01:09:13,480
BOTH A POINT OF PRIDE AND

1633
01:09:13,480 --> 01:09:14,680
OPPORTUNITY AND SOMETIMES A

1634
01:09:14,680 --> 01:09:16,680
CHALLENGE FOR THE NEW SCIENTIFIC

1635
01:09:16,680 --> 01:09:19,920
DIRECTOR. THESE ARE JUST

1636
01:09:19,920 --> 01:09:22,280
EXAMPLES OF THE PEOPLE IN THE

1637
01:09:22,280 --> 01:09:27,320
OFFICE OF SCIENTIFIC DIRECTORS

1638
01:09:27,320 --> 01:09:31,360
STAFF, RACHEL SCHACHERER REALLY

1639
01:09:31,360 --> 01:09:32,760
LEADS THE GROUP. MANY OF YOU

1640
01:09:32,760 --> 01:09:35,760
HAVE BEEN INTERACTIVE, IF YOU

1641
01:09:35,760 --> 01:09:41,120
HAVE ON THE GROUP WITH LIZA

1642
01:09:41,120 --> 01:09:45,920
LITVINA, SIMON HALEGOUA DEPUTY

1643
01:09:45,920 --> 01:09:48,400
SUPERB PARTNER, I VET PITMAN IS

1644
01:09:48,400 --> 01:09:52,680
INVOLVED IN TRAINING AND CAREER

1645
01:09:52,680 --> 01:09:57,480
DEVELOPMENT, ANGEL DE LA CRUZ

1646
01:09:57,480 --> 01:09:58,920
LANDRAU IS IN OUR SUMMER

1647
01:09:58,920 --> 01:10:00,240
PROGRAMS AND PROGRAMS FOR

1648
01:10:00,240 --> 01:10:02,440
MINORITY INDIVIDUALS AND RITA

1649
01:10:02,440 --> 01:10:05,480
DEVINE, SHE SAYS SHE'S INVOLVED

1650
01:10:05,480 --> 01:10:06,960
IN SPACE AND FA IT ISES AND

1651
01:10:06,960 --> 01:10:09,840
TRAINING, SHE IS THE UTILITY

1652
01:10:09,840 --> 01:10:14,640
OUTFIELDER WHO REALLY HANDLES

1653
01:10:14,640 --> 01:10:16,960
BROAD SWATH OF WHAT GOES IN THE

1654
01:10:16,960 --> 01:10:18,720
INTRAMURAL PROGRAM. WE HAVE

1655
01:10:18,720 --> 01:10:21,640
NAVIGATED, I THINK QUITE

1656
01:10:21,640 --> 01:10:22,640
SUCCESSFULLY HOW WE DO SCIENCE

1657
01:10:22,640 --> 01:10:24,760
AND STAY IN TOUCH WITH ONE

1658
01:10:24,760 --> 01:10:29,640
ANOTHER AND DO EDUCATION AND

1659
01:10:29,640 --> 01:10:33,120
TRAINING IN THE ERA OF COVID. I

1660
01:10:33,120 --> 01:10:35,360
THINK WE WILL BOTH HELP AND I

1661
01:10:35,360 --> 01:10:38,480
THINK MORE THAN ANYTHING ELSE

1662
01:10:38,480 --> 01:10:40,640
INFORM THE -- AND MAKE THINGS

1663
01:10:40,640 --> 01:10:44,800
EASIER FOR THE NEXT SCIENTIFIC

1664
01:10:44,800 --> 01:10:47,240
DIRECTOR. I THINK YOU BEGIN

1665
01:10:47,240 --> 01:10:49,240
SUCCESSION PLANNING THE DAY THE

1666
01:10:49,240 --> 01:10:53,440
NEW PERSON ON THE BLOCK ARRIVES.

1667
01:10:53,440 --> 01:10:56,560
WE HAVE BEGUN SEVERAL PROGRAMS

1668
01:10:56,560 --> 01:10:59,080
INVOLVED IN MENTORING FOR MANY

1669
01:10:59,080 --> 01:11:04,040
OF OUR SCIENTISTS FOR LEADER 

1670
01:11:04,040 --> 01:11:05,240
LEADERSHIP, DESPITE THE FACT

1671
01:11:05,240 --> 01:11:07,880
THAT WE HAVE WHAT HAS BEEN

1672
01:11:07,880 --> 01:11:10,080
CALLED A FLAT ORGANIZATIONAL

1673
01:11:10,080 --> 01:11:12,840
STRUCTURE, WE MUST BEGIN

1674
01:11:12,840 --> 01:11:13,520
CREATING NEW OPPORTUNITIES FOR

1675
01:11:13,520 --> 01:11:17,480
GRADED LEADERSHIP, WE MUST

1676
01:11:17,480 --> 01:11:19,640
ENABLE TRANSITIONS FOR

1677
01:11:19,640 --> 01:11:21,200
INDIVIDUALS THAT ARE INTERESTED

1678
01:11:21,200 --> 01:11:24,760
IN TAKING ON LEADERSHIP

1679
01:11:24,760 --> 01:11:27,240
POSITIONS. I THINK WE HAVE TO

1680
01:11:27,240 --> 01:11:29,040
RECOGNIZE AND ADVANCE THE TALENT

1681
01:11:29,040 --> 01:11:32,400
AND INTEREST OF THOSE PEOPLE,

1682
01:11:32,400 --> 01:11:34,080
AND WE HAVE TO BEGIN DOING THIS

1683
01:11:34,080 --> 01:11:37,120
AS I SAID BEFORE THE END OF THE

1684
01:11:37,120 --> 01:11:41,360
TERM OF THE NEXT SCIENTIFIC

1685
01:11:41,360 --> 01:11:46,640
DIRECTOR. AND I THINK WE AT NIH

1686
01:11:46,640 --> 01:11:49,600
AND CERTAINLY I SAW THIS DURING

1687
01:11:49,600 --> 01:11:52,120
MY MORE THAN 30 YEARS IN THE

1688
01:11:52,120 --> 01:11:54,640
ACADEMIC SECTOR, IT IS A

1689
01:11:54,640 --> 01:11:57,480
HALLMARK OF SCIENTISTS IN SOME

1690
01:11:57,480 --> 01:12:00,040
MEASURE THAT WE TREAT LEADERS AS

1691
01:12:00,040 --> 01:12:01,800
IF THEY ARE -- I'M GOING TO USE

1692
01:12:01,800 --> 01:12:05,360
A TERM I HAVE HEARD USED JUST

1693
01:12:05,360 --> 01:12:08,000
ADMINISTRATORS, I THINK WE HAVE

1694
01:12:08,000 --> 01:12:10,560
TO BUILD RESPECT AND REALLY

1695
01:12:10,560 --> 01:12:13,320
RECOGNIZE THE FACT THAT AN

1696
01:12:13,320 --> 01:12:15,560
ADMINISTRATOR WHO IS NOT JUST

1697
01:12:15,560 --> 01:12:17,560
ADMINISTRATOR BUT IS A LEADER IS

1698
01:12:17,560 --> 01:12:20,160
A RARE COMMODITY AND IT IS NOT

1699
01:12:20,160 --> 01:12:21,680
SOMETHING THAT ANYBODY IS BORN

1700
01:12:21,680 --> 01:12:25,760
KNOWING HOW TO DO. WE HAVE TO

1701
01:12:25,760 --> 01:12:27,480
BREED THESE PEOPLE, WE HAVE TO

1702
01:12:27,480 --> 01:12:31,080
NURTURE THESE PEOPLE AND WE HAVE

1703
01:12:31,080 --> 01:12:32,240
TO TRAIN AND RESPECT THESE

1704
01:12:32,240 --> 01:12:37,120
PEOPLE FOR WHAT THEY BRING TO

1705
01:12:37,120 --> 01:12:40,720
THE SCIENTIFIC ENTERPRISE. SO I

1706
01:12:40,720 --> 01:12:43,520
WANT TO SHOW YOU SOME OF OUR --

1707
01:12:43,520 --> 01:12:51,760
I THINK FUTURE LEADERS, DERRICK

1708
01:12:51,760 --> 01:12:53,800
NURENDA WAS NAME AD LASKER

1709
01:12:53,800 --> 01:12:55,400
SCHOLAR, PHYSICIAN SCHOLAR,

1710
01:12:55,400 --> 01:12:57,600
DECEMBER MONDAY BROWN IS LATEST

1711
01:12:57,600 --> 01:12:59,320
IN SUCCESSION OF DISTINGUISHED

1712
01:12:59,320 --> 01:13:04,320
SCHOLARS NAMED BY NIH AS A WHOLE

1713
01:13:04,320 --> 01:13:09,720
AND QWON WAS AWARDED TENURE THIS

1714
01:13:09,720 --> 01:13:15,920
YEAR DESPITE I WAS A NEONIGHT

1715
01:13:15,920 --> 01:13:17,840
PRESENTING PEOPLE BEFORE TENURE

1716
01:13:17,840 --> 01:13:20,640
AT NIH. I DON'T KNOW WHO WAS

1717
01:13:20,640 --> 01:13:23,600
MORE NERVOUS ABOUT THIS QWON OR

1718
01:13:23,600 --> 01:13:26,840
ME BUT SHE EARNED IT AND AWARDED

1719
01:13:26,840 --> 01:13:30,200
THIS YEAR. VERY EXCITING

1720
01:13:30,200 --> 01:13:34,440
SUCCESSION PLANNING, SIMON IS

1721
01:13:34,440 --> 01:13:37,240
THE CLOSEST WE CURRENTLY HAVE TO

1722
01:13:37,240 --> 01:13:41,480
A DEPUTY SCIENTIFIC DIRECTOR.

1723
01:13:41,480 --> 01:13:42,680
WILL BE RETIRING FROM THAT

1724
01:13:42,680 --> 01:13:46,360
POSITION AND GOING BACK TO HIS

1725
01:13:46,360 --> 01:13:51,520
FACULTY POSITION AT STONY BROOK

1726
01:13:51,520 --> 01:13:53,120
ONE OF OUR STAFF SCIENTISTS WHO

1727
01:13:53,120 --> 01:13:55,880
HAD BEEN DOING PROJECT

1728
01:13:55,880 --> 01:13:58,520
MANAGEMENT FOR OUR PRESENCE BILL

1729
01:13:58,520 --> 01:14:01,480
INVESTIGATOR DAVID SIBLEY. FOR

1730
01:14:01,480 --> 01:14:05,000
MANY, MANY YEARS BEN WORKS AS

1731
01:14:05,000 --> 01:14:07,600
DOES DAVID ON ALLOSTERIC

1732
01:14:07,600 --> 01:14:11,800
REGULATION OF BINDING OF LIGANDS

1733
01:14:11,800 --> 01:14:14,240
TO DOPAMINERGIC FAMILY OF

1734
01:14:14,240 --> 01:14:16,440
RECEPTORS. BEN EXPRESSED AN

1735
01:14:16,440 --> 01:14:19,080
INTEREST IN REALLY SHOWED

1736
01:14:19,080 --> 01:14:21,040
APTITUDE DURING COVID OF MOVING

1737
01:14:21,040 --> 01:14:24,080
FROM PROJECT MANAGEMENT TO

1738
01:14:24,080 --> 01:14:25,520
PROGRAM MANAGEMENT AND SO WE

1739
01:14:25,520 --> 01:14:29,960
HAVE RECRUITED HIM WITH DAVE'S

1740
01:14:29,960 --> 01:14:31,600
BLESSING AND HELP TO THE OFFICE

1741
01:14:31,600 --> 01:14:35,160
OF THE SCIENTIFIC DIRECTOR. HE

1742
01:14:35,160 --> 01:14:37,720
WILL LARGELY TAKE SIMON'S PLACE

1743
01:14:37,720 --> 01:14:43,080
AS SIMON MOVES ON BACK TO STONY

1744
01:14:43,080 --> 01:14:46,120
BROOK. REALLY EXCITED ABOUT

1745
01:14:46,120 --> 01:14:48,960
THAT, REALLY THRILLED TO BE

1746
01:14:48,960 --> 01:14:52,000
WORKING NOW WITH BEN AS HE

1747
01:14:52,000 --> 01:14:53,280
TRANSITIONS. WE HEARD IN THIS

1748
01:14:53,280 --> 01:14:57,360
GROUP ABOUT THE BEACON PROGRAM

1749
01:14:57,360 --> 01:15:01,400
THAT OUR CLINICAL DIRECTOR AVI

1750
01:15:01,400 --> 01:15:05,000
AND OUR FORMER ADMINISTRATIVE

1751
01:15:05,000 --> 01:15:09,160
DEPUTY DIRECTOR MAUREEN GORMLEY

1752
01:15:09,160 --> 01:15:12,280
SPEARHEADED PROGRAM CALLED

1753
01:15:12,280 --> 01:15:14,400
BEACON. THAT PROVIDES CAREER

1754
01:15:14,400 --> 01:15:17,640
DEVELOPMENT AND LEADERSHIP

1755
01:15:17,640 --> 01:15:18,640
OPPORTUNITIES FOR OUR

1756
01:15:18,640 --> 01:15:21,840
NEUROSCIENCE NURSES IN THE

1757
01:15:21,840 --> 01:15:24,080
INTRAMURAL PROGRAM. POTENTIAL

1758
01:15:24,080 --> 01:15:26,640
FOR SUCCESSION PLANNING BUT

1759
01:15:26,640 --> 01:15:28,320
REALLY AN OPPORTUNITY FOR CAREER

1760
01:15:28,320 --> 01:15:31,560
DEVELOPMENT AND ADVANCEMENT FOR

1761
01:15:31,560 --> 01:15:34,320
PEOPLE IN THE CLINICAL PART OF

1762
01:15:34,320 --> 01:15:37,240
OUR INTRAMURAL PROGRAM AND

1763
01:15:37,240 --> 01:15:39,600
FINALLY WE CONDUCTED FOR THE

1764
01:15:39,600 --> 01:15:45,160
LAST COUPLE OF YEARS AN ENTIRELY

1765
01:15:45,160 --> 01:15:49,400
REMOTE SUMMER INTERNSHIP PROGRAM

1766
01:15:49,400 --> 01:15:52,840
AT NINDS. EVEN I WAS AMAZED AT

1767
01:15:52,840 --> 01:15:55,720
HOW EFFECTIVE THIS PROGRAM WAS.

1768
01:15:55,720 --> 01:15:58,360
WE HAD VIRTUAL PRESENTATIONS AND

1769
01:15:58,360 --> 01:16:00,920
POSTERS, WE HAVE CLASSES, WE HAD

1770
01:16:00,920 --> 01:16:03,320
PROJECTS THAT EVOLVED IN WAYS

1771
01:16:03,320 --> 01:16:05,560
THAT I NEVER WOULD HAVE EXPECTED

1772
01:16:05,560 --> 01:16:09,480
COULD BE DONE ON ZOOM. JUST

1773
01:16:09,480 --> 01:16:12,000
INCREDIBLY DIVERSE ENGAGED

1774
01:16:12,000 --> 01:16:15,200
INVOLVED AND SCARY SMART

1775
01:16:15,200 --> 01:16:18,800
COLLECTION OF UNDERGRADUATES AND

1776
01:16:18,800 --> 01:16:20,280
MEDICAL STUDENTS WHO JOINED US

1777
01:16:20,280 --> 01:16:22,360
FOR THE SUMMER AND REALLY

1778
01:16:22,360 --> 01:16:25,840
DEVELOPED AMAZING PROJECTS. SO I

1779
01:16:25,840 --> 01:16:28,600
HOPE THAT WITH THE RECRUITMENT

1780
01:16:28,600 --> 01:16:31,320
ONGOING OF OUR NEXT SCIENTIFIC

1781
01:16:31,320 --> 01:16:34,800
DIRECTOR WE WILL GO AS THEY SAY,

1782
01:16:34,800 --> 01:16:35,920
FROM STRENGTH TO NEW STRENGTH. I

1783
01:16:35,920 --> 01:16:38,240
THANK YOU FOR YOUR ATTENTION AND

1784
01:16:38,240 --> 01:16:38,920
I'M HAPPY TO ANSWER ANY

1785
01:16:38,920 --> 01:16:48,080
QUESTIONS. 

1786
01:16:48,080 --> 01:16:50,280
>> I SEE PEOPLE APPLAUDING
AND

1787
01:16:50,280 --> 01:16:51,160
THERE'S COMPLIMENTARY COMMENTS

1788
01:16:51,160 --> 01:16:52,840
IN THE CHAT.  A HAND WENT UP

1789
01:16:52,840 --> 01:16:56,480
THEN KI DISAPPEARED.  ARE THEREY

1790
01:16:56,480 --> 01:17:01,280
QUESTIONS? ALLAN, YOU ARE MUTED 

1791
01:17:01,280 --> 01:17:03,680
>> I HAVE JUST A GENERAL

1792
01:17:03,680 --> 01:17:05,720
QUESTION. I'M CURIOUS ABOUT TO

1793
01:17:05,720 --> 01:17:08,680
WHAT EXTENT ARE YOU ABLE GET

1794
01:17:08,680 --> 01:17:11,320
INTERACTION FROM A SCIENTIFIC

1795
01:17:11,320 --> 01:17:12,560
AND EVEN OTHERWISE BETWEEN BASIC

1796
01:17:12,560 --> 01:17:13,520
SCIENTIST AND CLINICAL

1797
01:17:13,520 --> 01:17:16,320
SCIENTIST? IT IS A HUGE ISSUE ON

1798
01:17:16,320 --> 01:17:18,920
THE UNIVERSITY SIDE NOW WHERE

1799
01:17:18,920 --> 01:17:20,440
MONEY COMING INTO THE HOSPITAL

1800
01:17:20,440 --> 01:17:23,080
IS SO KEY TO SURVIVAL ALMOST

1801
01:17:23,080 --> 01:17:25,200
MAKING IT MORE COMPLICATED, I

1802
01:17:25,200 --> 01:17:27,400
WONDER IS THERE A SPECIFIC

1803
01:17:27,400 --> 01:17:29,480
EFFORT TO ENCOURAGE THAT OR THIS

1804
01:17:29,480 --> 01:17:31,480
JUST HAPPEN HOPEFULLY?

1805
01:17:31,480 --> 01:17:34,640
>> THERE IS -- THERE IS A

1806
01:17:34,640 --> 01:17:37,880
SPECIFIC EFFORT, I HAVE MADE IT

1807
01:17:37,880 --> 01:17:40,680
MY JOB, IT IS WHAT I DID IN THE

1808
01:17:40,680 --> 01:17:44,640
ACADEMIC SECTOR FOR 30 YEARS. SO

1809
01:17:44,640 --> 01:17:46,760
IT WAS VERY -- TO ME IT FELT

1810
01:17:46,760 --> 01:17:48,760
LIKE AN IMPERATIVE AND PELT LIKE

1811
01:17:48,760 --> 01:17:51,800
A DISAPPOINTMENT TO NOT HAVE

1812
01:17:51,800 --> 01:17:55,280
SEEN THAT AS I ASSUME THIS

1813
01:17:55,280 --> 01:17:59,600
POSITION. IT DOES -- I THINK IT

1814
01:17:59,600 --> 01:18:01,720
TAKES AN EFFORT AND IT IS FUNNY

1815
01:18:01,720 --> 01:18:04,240
THAT WE ARE, ON MANY ACADEMIC

1816
01:18:04,240 --> 01:18:07,600
CAMPUSES THE HOSPITALS ARE

1817
01:18:07,600 --> 01:18:09,480
PHYSICALLY QUITE DISTANT FROM

1818
01:18:09,480 --> 01:18:12,600
THE GRADUATE SCHOOL CAMPUS. SO

1819
01:18:12,600 --> 01:18:13,800
YOU ARE TALKING ABOUT PEOPLE

1820
01:18:13,800 --> 01:18:19,320
GETTING THEIR CARS. FOR US IT IS

1821
01:18:19,320 --> 01:18:21,360
FIVE, TEN MINUTE WALK ON THE

1822
01:18:21,360 --> 01:18:24,760
SAME CAMPUS BUILDING 10 AND

1823
01:18:24,760 --> 01:18:26,560
BUILDING 35 DEPENDING HOW

1824
01:18:26,560 --> 01:18:28,400
QUICKLY YOU WALK, I'M NOT A

1825
01:18:28,400 --> 01:18:29,920
SPRING CHICKEN ANY MORE BUT

1826
01:18:29,920 --> 01:18:31,640
MAYBE IT TAKES ME EIGHT MINUTES

1827
01:18:31,640 --> 01:18:35,400
TO GO FROM BUILDING 35 TO

1828
01:18:35,400 --> 01:18:38,680
BUILDING 10. YET THE DISTANCE

1829
01:18:38,680 --> 01:18:42,600
PHILOSOPHICALLY AND THE DISTANCE

1830
01:18:42,600 --> 01:18:45,680
INTELLECTUALLY IS MUCH BIGGER

1831
01:18:45,680 --> 01:18:47,760
THAN THAT. I DON'T THINK THERE

1832
01:18:47,760 --> 01:18:51,360
IS ANY ANIMOSITY AT AL ALL. I DT

1833
01:18:51,360 --> 01:18:52,600
THINK ANYBODY FEELS NEGATIVELY

1834
01:18:52,600 --> 01:18:54,520
ABOUT THAT. I THINK PEOPLE ARE

1835
01:18:54,520 --> 01:18:59,320
IN THEIR CACOON AND DON'T THINK

1836
01:18:59,320 --> 01:19:02,480
TO DO IT. SO IT TAKES CONVENERS,

1837
01:19:02,480 --> 01:19:05,000
PART OF WHAT IT IS TO BE A

1838
01:19:05,000 --> 01:19:07,600
LEADER IS TO SIT AT 30,000 FEET

1839
01:19:07,600 --> 01:19:10,000
SO YOU SEE THE WHOLE LANDSCAPE

1840
01:19:10,000 --> 01:19:12,600
AND MAKE THE PERSON ON THE LEFT

1841
01:19:12,600 --> 01:19:14,840
KNOW THAT THE PERSON ON THE

1842
01:19:14,840 --> 01:19:18,040
RIGHT IS DOING SOMETHING THAT

1843
01:19:18,040 --> 01:19:19,720
MIGHT BE OF INTEREST TO THEM. IN

1844
01:19:19,720 --> 01:19:24,240
THE YEARS THAT I HAVE BEEN THE

1845
01:19:24,240 --> 01:19:25,640
SCIENTIFIC DIRECTOR ONE OF THE

1846
01:19:25,640 --> 01:19:28,880
-- SOME OF THE SIMPLEST THINGS

1847
01:19:28,880 --> 01:19:30,880
HAVE FOSTERED BIG

1848
01:19:30,880 --> 01:19:34,560
COLLABORATIONS. SIMPLE CHEAP

1849
01:19:34,560 --> 01:19:36,760
COST FREE THINGS LIKE SAYING

1850
01:19:36,760 --> 01:19:40,600
THAT IF WE ARE GOING TO HAVE

1851
01:19:40,600 --> 01:19:42,400
CLINICAL GRAND ROUNDS AND IT IS

1852
01:19:42,400 --> 01:19:45,040
GOING TO BE A RESEARCH INTENSIVE

1853
01:19:45,040 --> 01:19:46,840
OFTEN BASIC SCIENCE ORIENTED

1854
01:19:46,840 --> 01:19:48,360
GRAND ROUNDS IN THE HOSPITAL, WE

1855
01:19:48,360 --> 01:19:51,320
ARE GOING TO NOW DO IT ON ZOOM,

1856
01:19:51,320 --> 01:19:53,920
WHY DON'T WE JUST TELL EVERYBODY

1857
01:19:53,920 --> 01:19:55,040
IN THE INTRAMURAL PROGRAM THAT

1858
01:19:55,040 --> 01:19:56,800
THIS IS GOING TO HAPPEN SO SOME

1859
01:19:56,800 --> 01:20:01,320
OF THE BASIC SCIENTISTS CAN

1860
01:20:01,320 --> 01:20:03,360
LISTEN IN. IT REALLY HAS MADE IT

1861
01:20:03,360 --> 01:20:06,960
EASY TO DO THAT. SO THERE IS NO

1862
01:20:06,960 --> 01:20:07,520
PHYSICAL DISTANCE YOU CAN

1863
01:20:07,520 --> 01:20:07,920
TRAVEL.

1864
01:20:07,920 --> 01:20:10,440
>> ONE SUGGESTION, YEARS
AGO I

1865
01:20:10,440 --> 01:20:13,480
RAN A PROGRAM AT THE AMERICAN --

1866
01:20:13,480 --> 01:20:14,280
SOCIETY CALLED THE PAIN PATIENT

1867
01:20:14,280 --> 01:20:17,120
FOR THE BASIC SCIENTIST. WHERE

1868
01:20:17,120 --> 01:20:20,880
THE CLINICIAN ACTUALLY PRESENTED

1869
01:20:20,880 --> 01:20:22,040
PATIENTS, THIS WAS -- THEY HAD

1870
01:20:22,040 --> 01:20:23,760
FROM A BASIC SCIENTIST, A

1871
01:20:23,760 --> 01:20:26,440
NEUROLOGIST AND A PSYCHIATRIST,

1872
01:20:26,440 --> 01:20:27,600
DISCUSSING AND IT WAS A REAL

1873
01:20:27,600 --> 01:20:31,280
PATIENT THERE. IT WAS INCREDIBLY

1874
01:20:31,280 --> 01:20:32,960
INFORMATIVE. MY BIG PUSH IS TO

1875
01:20:32,960 --> 01:20:34,200
TRY TO EXPLAIN TO PEOPLE IN MY

1876
01:20:34,200 --> 01:20:35,200
LAB THAT A MOUSE IS A NOT A

1877
01:20:35,200 --> 01:20:39,440
HUMAN.  THAT WHAT WE LEARNED

1878
01:20:39,440 --> 01:20:40,880
DOES TRANSLATE, BUT THERE IS A

1879
01:20:40,880 --> 01:20:42,040
DIFFERENT BRAIN ATTACHED.  EVEN

1880
01:20:42,040 --> 01:20:44,160
TO GET THE BASIC SCIENTISTS

1881
01:20:44,160 --> 01:20:46,400
INVITED TO SHADOW PERIODICALLY

1882
01:20:46,400 --> 01:20:48,080
PEOPLE IN MY LAB DO THAT, THEY

1883
01:20:48,080 --> 01:20:50,240
GO TO PAIN CLINIC. AND IT IS AN

1884
01:20:50,240 --> 01:20:51,760
EXPERIENCE THAT INFLUENCES THE

1885
01:20:51,760 --> 01:20:55,560
WAY THEY THINK ABOUT THEIR

1886
01:20:55,560 --> 01:20:56,640
SCIENCE. I WOULD HOPE YOU CAN DO

1887
01:20:56,640 --> 01:20:58,240
THAT AT THE NIH LEVEL ESPECIALLY

1888
01:20:58,240 --> 01:21:00,000
WHEN THE HOSPITAL IS SO CLOSE. 

1889
01:21:00,000 --> 01:21:01,680
>> I COULDN'T AGREE WITH
YOU

1890
01:21:01,680 --> 01:21:04,000
MORE. NOW IT IS A LITTLE BIT

1891
01:21:04,000 --> 01:21:07,600
CHALLENGING BECAUSE OF THE

1892
01:21:07,600 --> 01:21:11,960
REQUIREMENTS WITH COVID IN THE

1893
01:21:11,960 --> 01:21:13,360
PATIENT ENVIRONMENT. WE HAVE

1894
01:21:13,360 --> 01:21:14,560
STARTED SOMETHING THAT I HAD

1895
01:21:14,560 --> 01:21:17,840
DONE WHEN I WAS IN ROCHESTER

1896
01:21:17,840 --> 01:21:19,800
WHERE THE FIRST 10 OR 15 MINUTES

1897
01:21:19,800 --> 01:21:25,400
OF EVERY FACULTY MEETING IS A

1898
01:21:25,400 --> 01:21:26,520
DATA GLITS BY SOMEBODY IN EITHER

1899
01:21:26,520 --> 01:21:29,720
CLINICAL OR BASIC RESEARCH WHERE

1900
01:21:29,720 --> 01:21:33,080
THEY GET UP AND THEY HAVE TO

1901
01:21:33,080 --> 01:21:35,120
PRESENT SOME DATA THAT HASN'T

1902
01:21:35,120 --> 01:21:36,280
YET BEEN PUBLISHED BECAUSE

1903
01:21:36,280 --> 01:21:38,440
EVERYBODY CAN READ THE

1904
01:21:38,440 --> 01:21:42,400
PUBLICATIONS. THEY GET UP THERE

1905
01:21:42,400 --> 01:21:44,480
AND SHOW THREE, FOUR SLIDES

1906
01:21:44,480 --> 01:21:47,320
MAXIMUM, SOME OF THEM JUST ONE

1907
01:21:47,320 --> 01:21:51,200
SLIDE. AND EVERYBODY HAS A VERY

1908
01:21:51,200 --> 01:21:53,520
ENGAGED DISCUSSION. WE HAD

1909
01:21:53,520 --> 01:21:56,640
COLLABORATIONS ALREADY DEVELOPED

1910
01:21:56,640 --> 01:21:59,880
OUT OF THAT. I JUST THINK PART

1911
01:21:59,880 --> 01:22:02,480
OF IT IS JUXTAPOSING PEOPLE WHO

1912
01:22:02,480 --> 01:22:04,760
DON'T ORDINARILY THINK OF COMING

1913
01:22:04,760 --> 01:22:08,520
TOGETHER. THERE IS NOBODY MEAN

1914
01:22:08,520 --> 01:22:09,560
OR PRIVATE OR WHATEVER, IT IS

1915
01:22:09,560 --> 01:22:15,760
JUST PEOPLE THAT NEVER MET.

1916
01:22:15,760 --> 01:22:18,560
>> ECHOING ALLAN, IT SEEMS
YOU

1917
01:22:18,560 --> 01:22:19,400
HAVE THIS GREAT OPPORTUNITY

1918
01:22:19,400 --> 01:22:23,840
BECAUSE I KNOW EXAMPLES THAT ARE

1919
01:22:23,840 --> 01:22:24,760
INCREDIBLY GREAT TEMPLATES

1920
01:22:24,760 --> 01:22:26,880
GETTING BASIC SCIENCE IMPACTFUL

1921
01:22:26,880 --> 01:22:28,240
ON CLINICAL SCIENCE AND VICE

1922
01:22:28,240 --> 01:22:29,240
VERSA WITHIN YOUR INSTITUTE. I

1923
01:22:29,240 --> 01:22:32,480
WAS THINKING OF THE WORK ON CASO

1924
01:22:32,480 --> 01:22:34,160
WITHOUT NAMING NAMES THAT TURNED

1925
01:22:34,160 --> 01:22:36,760
OUT REALLY IMPORTANT. BECAUSE IT

1926
01:22:36,760 --> 01:22:38,000
SHOWED UP IN HUMANS WITH

1927
01:22:38,000 --> 01:22:41,920
MUTATIONS.  COMPLETELY

1928
01:22:41,920 --> 01:22:44,200
UNEXPECTED ROLE FOR THIS,

1929
01:22:44,200 --> 01:22:46,280
CHANNEL IN THAT ASPECT OF THE

1930
01:22:46,280 --> 01:22:48,560
DISEASE, WHAT I WOULD LIKE TO

1931
01:22:48,560 --> 01:22:49,880
MAKE SURE EVERYONE IS AWARE THAT

1932
01:22:49,880 --> 01:22:51,760
THESE CONNECTIONS HAPPEN. THIS

1933
01:22:51,760 --> 01:22:53,920
IS -- SO ACQUAINT ALWAYS PLAN

1934
01:22:53,920 --> 01:22:55,680
FOR IT BUT SOMETIMES BASIC

1935
01:22:55,680 --> 01:22:57,800
SCIENTISTS, THEY THINK OF IT AS

1936
01:22:57,800 --> 01:23:00,200
PEOPLE WHO DO CLINICAL DISEASE

1937
01:23:00,200 --> 01:23:02,080
HUNTING, FOCUS ON DISEASE, THEY

1938
01:23:02,080 --> 01:23:03,320
HAVE A FEW CLUES DOWN THAT PATH

1939
01:23:03,320 --> 01:23:04,640
BUT SOMETIMES IT DOESN'T HAPPEN

1940
01:23:04,640 --> 01:23:06,480
THAT WAY. IT REALLY HAPPENS

1941
01:23:06,480 --> 01:23:07,840
BECAUSE YOU HAD TRUE BASIC

1942
01:23:07,840 --> 01:23:09,200
INTEREST AND MADE AWARE OF THE

1943
01:23:09,200 --> 01:23:11,280
CONNECTIONS THAT ARE POSSIBLE.

1944
01:23:11,280 --> 01:23:13,000
SO I THINK THE GOOD THING TO DO

1945
01:23:13,000 --> 01:23:14,680
IS TO MAKE AS MANY PEOPLE AWARE

1946
01:23:14,680 --> 01:23:18,040
OF IT AS POSSIBLE.

1947
01:23:18,040 --> 01:23:23,160
>> SO YOU REMIND ME TO
MENTION

1948
01:23:23,160 --> 01:23:25,120
THAT LORENA INITIATED SOMETHING

1949
01:23:25,120 --> 01:23:29,200
THAT IS NOW EXTREMELY ROBUST.

1950
01:23:29,200 --> 01:23:34,280
AND THAT IS A SMALL GRANT

1951
01:23:34,280 --> 01:23:35,800
MECHANISM INTERNAL THAT WE

1952
01:23:35,800 --> 01:23:39,440
PROVIDE FROM THE INTRAMURAL

1953
01:23:39,440 --> 01:23:43,680
BUDGET FOR CARES OR TEAMS OF

1954
01:23:43,680 --> 01:23:45,960
PEOPLE WHO WORK ON SOMETHING AT

1955
01:23:45,960 --> 01:23:48,920
THE INTERFACE BETWEEN A CLINICAL

1956
01:23:48,920 --> 01:23:51,160
PROBLEM AND A SCIENTIFIC

1957
01:23:51,160 --> 01:23:54,800
OBSERVATION, THESE COLLABORATIVE

1958
01:23:54,800 --> 01:23:58,080
GROUPS. AN EXAMPLE VERY MUCH

1959
01:23:58,080 --> 01:24:04,200
LIKE PIASO STORY IS THE ATP 1A 3

1960
01:24:04,200 --> 01:24:08,040
STORY WITH ALTERNATING

1961
01:24:08,040 --> 01:24:09,560
HEMIPLAGIA. THERE WAS AN

1962
01:24:09,560 --> 01:24:12,240
INDIVIDUAL PARTICULARLY

1963
01:24:12,240 --> 01:24:13,440
INTERESTED CLINICALLY IN

1964
01:24:13,440 --> 01:24:16,480
ALTERNATING HEMIPLEGIA AND

1965
01:24:16,480 --> 01:24:18,640
RELATED DISORDERS. THERE IS A

1966
01:24:18,640 --> 01:24:20,880
WHOLE SPECTRUM, SOME OF THEM NOT

1967
01:24:20,880 --> 01:24:23,000
EVEN CLEAR AT THIS POINT WHY

1968
01:24:23,000 --> 01:24:24,640
THEY CO-SEGREGATE WITH

1969
01:24:24,640 --> 01:24:27,720
ALTERNATING HEMIPLEGIA. IT TURNS

1970
01:24:27,720 --> 01:24:29,360
OUT THESE PATIENTS HAVE

1971
01:24:29,360 --> 01:24:36,640
MUTATIONS OF THE ATP 1A 3

1972
01:24:36,640 --> 01:24:40,440
CHANNEL. WE HAD A BASIC

1973
01:24:40,440 --> 01:24:41,640
SCIENTIST IN OUR PROGRAM THAT

1974
01:24:41,640 --> 01:24:44,360
WAS ACTUALLY WORKING ON SODIUM

1975
01:24:44,360 --> 01:24:47,040
PUMPS AND ATP 1A 3 CHANNELS AND

1976
01:24:47,040 --> 01:24:49,480
SO FORTH THAT HAD NO IDEA THIS

1977
01:24:49,480 --> 01:24:52,520
DISEASE EXISTED.  TWO OF THEM

1978
01:24:52,520 --> 01:24:57,720
NOW ARE FUELED BY THIS GRANT TO

1979
01:24:57,720 --> 01:25:02,320
WORK TOGETHER. I THINK AS I SAY,

1980
01:25:02,320 --> 01:25:04,200
90% OF IT IS JUST MAKING PEOPLE

1981
01:25:04,200 --> 01:25:07,960
AWARE OF ONE ANOTHER. 

1982
01:25:07,960 --> 01:25:11,480
>> YES, WHICH IS AS DAVID
POINTS

1983
01:25:11,480 --> 01:25:13,600
OUT IN THE CHAT IT IS MUTUALITY

1984
01:25:13,600 --> 01:25:15,480
SO DAN IS TALKING ON THE FLIP

1985
01:25:15,480 --> 01:25:17,840
SIDE BRINGING HOT TOPICS AND

1986
01:25:17,840 --> 01:25:19,000
BASIC RESEARCH TO THE ATTENTION

1987
01:25:19,000 --> 01:25:20,760
OF CLINICIANS.  EDUCATING

1988
01:25:20,760 --> 01:25:22,040
CLINICIANS ABOUT WHAT IS GOING

1989
01:25:22,040 --> 01:25:24,080
ON AT A MECHANISTIC LEVEL FOR

1990
01:25:24,080 --> 01:25:26,520
EXAMPLE EQUALLY IMPORTANT. 

1991
01:25:26,520 --> 01:25:30,960
>> I THINK AVI DOES A
GREAT JOB

1992
01:25:30,960 --> 01:25:32,960
WITH -- DOES A FANTASTIC JOB OF

1993
01:25:32,960 --> 01:25:35,120
THAT WITH CLINICAL GRAND ROUNDS

1994
01:25:35,120 --> 01:25:38,040
BECAUSE CLINICAL GRAND ROUNDS

1995
01:25:38,040 --> 01:25:40,280
ARE A CASE PRESENTATION FOLLOWED

1996
01:25:40,280 --> 01:25:44,120
BY A MECHANISTIC TALK RELATED TO

1997
01:25:44,120 --> 01:25:45,800
THAT PARTICULAR PATIENT.

1998
01:25:45,800 --> 01:25:47,480
>> ARNOLD. 

1999
01:25:47,480 --> 01:25:49,080
>> I WANT TO BRING
ATTENTION TO

2000
01:25:49,080 --> 01:25:52,000
THE FACT THAT THERE HAS BEEN A

2001
01:25:52,000 --> 01:25:55,040
NEUROBIOLOGY DISEASE WORKSHOP AT

2002
01:25:55,040 --> 01:25:55,680
THE SOCIETY FOURNEAU SCIENCE, I

2003
01:25:55,680 --> 01:25:56,400
HAVE BEEN INVOLVED IN FOR A

2004
01:25:56,400 --> 01:25:57,800
DOZEN YEARS SPONSORED BY THE

2005
01:25:57,800 --> 01:25:59,600
NIH. THIS IS OF COURSE WHEN WE

2006
01:25:59,600 --> 01:26:01,080
HAD IN PERSON MEETINGS. AND IT

2007
01:26:01,080 --> 01:26:03,840
WAS TERRIFIC, IT WAS BASICALLY

2008
01:26:03,840 --> 01:26:05,800
BASIC SCIENCE PRESENTATION BUT

2009
01:26:05,800 --> 01:26:06,840
IT REQUIRED A PATIENT TO BE

2010
01:26:06,840 --> 01:26:08,760
BROUGHT IN AT THE BEGINNING. AND

2011
01:26:08,760 --> 01:26:10,600
CONSIST CUSSED IN FRONT OF

2012
01:26:10,600 --> 01:26:13,760
EVERYBODY. AT TIME DISEASE

2013
01:26:13,760 --> 01:26:15,000
ORIENTED, WE ARE AN OPEN EYE

2014
01:26:15,000 --> 01:26:16,880
EXPERIENCE FOR PEOPLE WHO DIDN'T

2015
01:26:16,880 --> 01:26:17,640
HAVE EXPOSURE TO PATIENTS

2016
01:26:17,640 --> 01:26:19,800
BEFORE. IT WAS EXTREMELY POPULAR

2017
01:26:19,800 --> 01:26:22,760
AND I THINK IT WAS VERY

2018
01:26:22,760 --> 01:26:23,640
EFFECTIVE, IT WAS STOPPED A

2019
01:26:23,640 --> 01:26:26,280
NUMBER OF YEARS AGO. IING HOW IT

2020
01:26:26,280 --> 01:26:27,920
WAS GREAT WHEN LAST WHILE IT WAS

2021
01:26:27,920 --> 01:26:30,360
BEING DONE. NOT SURE WHY IT WAS

2022
01:26:30,360 --> 01:26:32,280
STOPPED BUT I WOULD URGE THE NIH

2023
01:26:32,280 --> 01:26:33,960
TO CONSIDER RESTARTING. I HEARD

2024
01:26:33,960 --> 01:26:37,120
SOME RUMORS THAT IT WAS STOPPED

2025
01:26:37,120 --> 01:26:38,200
BECAUSE THEY FELT THE PURPOSE

2026
01:26:38,200 --> 01:26:40,320
HAD BEEN ACCOMPLISHED AND

2027
01:26:40,320 --> 01:26:42,720
SOCIETY FOR NEUROSCIENCE MEETING

2028
01:26:42,720 --> 01:26:43,480
HAD ENOUGH CLINICAL

2029
01:26:43,480 --> 01:26:45,160
PRESENTATIONS THAT THEY DIDN'T

2030
01:26:45,160 --> 01:26:47,440
NEED EXTRA BOOST. IF SO, THEN

2031
01:26:47,440 --> 01:26:50,560
THAT IS EVEN MORE SUCCESS FOR

2032
01:26:50,560 --> 01:26:52,000
THAT PROGRAM.

2033
01:26:52,000 --> 01:26:58,840
>> THAT IS NOT --

2034
01:26:58,840 --> 01:27:01,200
>> SORRY ABOUT THAT, THAT
IS NOT

2035
01:27:01,200 --> 01:27:04,600
EXACTLY TRUE. WE CAN TALK ABOUT

2036
01:27:04,600 --> 01:27:08,840
IT OFFLINE BUT YOU HAVE TO WRITE

2037
01:27:08,840 --> 01:27:11,080
A GRANT AND SOME PEOPLE JUST DID

2038
01:27:11,080 --> 01:27:13,760
NOT PUT ENOUGH EFFORT INTO

2039
01:27:13,760 --> 01:27:15,400
WRITING THE GRANT. NO WE WOULD

2040
01:27:15,400 --> 01:27:17,400
BE HAPPY TO DO THAT AGAIN. I RAN

2041
01:27:17,400 --> 01:27:19,800
A COURSE FOR 20 YEARS WITH BOB

2042
01:27:19,800 --> 01:27:23,200
BROWN WE DID THIS. FOR THE

2043
01:27:23,200 --> 01:27:24,200
GARAGE BAIT STUDENTS SO I THINK

2044
01:27:24,200 --> 01:27:26,240
IT IS VERY POWERFUL.

2045
01:27:26,240 --> 01:27:28,280
>> NINDS WAS COMPLETELY

2046
01:27:28,280 --> 01:27:30,240
INSTRUMENTAL IN THAT

2047
01:27:30,240 --> 01:27:31,200
NEUROBIOLOGY DISEASE AND MANY

2048
01:27:31,200 --> 01:27:33,520
STAFF WOULD GO DAY EARLY TO SFN

2049
01:27:33,520 --> 01:27:37,680
TO LISTEN, IT WAS GREAT.  ANY

2050
01:27:37,680 --> 01:27:39,080
LAST QUESTIONS, TIME MAYBE FOR

2051
01:27:39,080 --> 01:27:40,680
ONE MORE QUESTION TO ANYNA IF

2052
01:27:40,680 --> 01:27:44,160
THERE IS ONE?

2053
01:27:44,160 --> 01:27:54,480
>> THANKS A LOT. 

2054
01:27:56,200 --> 01:27:57,600
>> CAN'T HEAR YOU, BOB. 

2055
01:27:57,600 --> 01:28:00,200
>> I SAID I THINK I'M NEXT
ON

2056
01:28:00,200 --> 01:28:02,640
THE AGENDA, SEE IF I CAN

2057
01:28:02,640 --> 01:28:04,040
ACCOMPLISH THE FEAT OF SHARING

2058
01:28:04,040 --> 01:28:08,280
MY SCREEN I INTEND TO SCREW UP.

2059
01:28:08,280 --> 01:28:10,800
LET'S SEE. CAN YOU SEE THAT?

2060
01:28:10,800 --> 01:28:11,920
>> YES, BOB.

2061
01:28:11,920 --> 01:28:14,880
>> OKAY. PUTTING IT IN THE
SLIDE

2062
01:28:14,880 --> 01:28:16,640
MODE H. IN SLIDE MODE NOW,

2063
01:28:16,640 --> 01:28:20,240
RIGHT?

2064
01:28:20,240 --> 01:28:25,680
>> HOLD ON A SECOND. I'M
GOING

2065
01:28:25,680 --> 01:28:29,560
TO TALK FOR MAYBE TEN MINUTES

2066
01:28:29,560 --> 01:28:32,800
ABOUT PROPOSED UPDATE TO OUR

2067
01:28:32,800 --> 01:28:35,440
NINDS SPECIAL COUNCIL REVIEW,

2068
01:28:35,440 --> 01:28:38,240
AKA SCR PROCESS. THE UPDATE IS

2069
01:28:38,240 --> 01:28:40,480
ACTUALLY AS YOU WILL SEE PRETTY

2070
01:28:40,480 --> 01:28:41,800
MINOR BUT SINCE WE HAVE A WHOLE

2071
01:28:41,800 --> 01:28:43,400
BUNCH OF NEW PEOPLE I WANT TO

2072
01:28:43,400 --> 01:28:46,920
TALK A LITTLE BIT ABOUT SCR AND

2073
01:28:46,920 --> 01:28:55,120
HOW IT CAME ABOUT.  SO

2074
01:28:55,120 --> 01:28:56,360
ORIGINALLY I'M SEEING STRANGE

2075
01:28:56,360 --> 01:28:58,640
THINGS ON MY SCREEN, SOW YOU ARE

2076
01:28:58,640 --> 01:29:01,360
SEEING JUST MY SLIDE.

2077
01:29:01,360 --> 01:29:02,880
>> YES.

2078
01:29:02,880 --> 01:29:06,320
>> GREAT. NIH IMPLEMENTED
SCR

2079
01:29:06,320 --> 01:29:09,640
ABOUT TEN YEARS AGO AND JUST TO

2080
01:29:09,640 --> 01:29:12,160
OVERSIMPLIFY WHAT SCR IS THAT

2081
01:29:12,160 --> 01:29:14,160
EVERY COUNCIL MUST APPROVE NEW

2082
01:29:14,160 --> 01:29:16,080
RESEARCH APPLICATIONS WHEN PIs

2083
01:29:16,080 --> 01:29:18,040
ARE CURRENTLY HAVE NO MORE THAN

2084
01:29:18,040 --> 01:29:20,520
ONE MILLION IN DIRECT COSTS IN

2085
01:29:20,520 --> 01:29:21,840
ANNUAL NIH SUPPORT.  THAT WAS

2086
01:29:21,840 --> 01:29:23,120
THE ORIGINAL POLICY AND NOTE

2087
01:29:23,120 --> 01:29:25,120
THAT WE ARE JUST LOOKING AT NIH

2088
01:29:25,120 --> 01:29:29,360
SUPPORT. NOT HHMI, NOT OTHER

2089
01:29:29,360 --> 01:29:30,560
FOUNDATION SUPPORT AND IT WAS

2090
01:29:30,560 --> 01:29:33,240
ALSO MADE CLEAR THAT INDIVIDUAL

2091
01:29:33,240 --> 01:29:35,800
INSTITUTES CAN MODIFY THE SCR

2092
01:29:35,800 --> 01:29:37,640
PROCESS BUT THAT THEIR RULES

2093
01:29:37,640 --> 01:29:41,200
HAVE TO BE AT LEAST STRINGENT OF

2094
01:29:41,200 --> 01:29:44,040
THOSE AT NIH. SO WHY DID THIS

2095
01:29:44,040 --> 01:29:45,840
COME AGENT? I WILL JUST SHOW YOU

2096
01:29:45,840 --> 01:29:48,640
ONE PIECE OF DATA THAT WE SHOWED

2097
01:29:48,640 --> 01:29:53,600
MANY TIMES BY NIH. THERE IS A --

2098
01:29:53,600 --> 01:29:56,480
WHAT WE CALL PHENOMENON

2099
01:29:56,480 --> 01:29:57,640
HYPERCOMPETITION, HOPEFULLY YOU

2100
01:29:57,640 --> 01:30:01,120
CAN SEE MY CURSOR. THE NUMBER OF

2101
01:30:01,120 --> 01:30:03,800
AWARDS DURING THIS PARTICULAR

2102
01:30:03,800 --> 01:30:05,960
PERIOD, 2003, WAS THE END OF THE

2103
01:30:05,960 --> 01:30:07,800
BUDGET FIVE YEAR BUDGET DOUBLING

2104
01:30:07,800 --> 01:30:09,480
FOR MINI. AFTER THAT THE NUMBER

2105
01:30:09,480 --> 01:30:13,000
OF AWARDS ISSUED BY NIH STAYED

2106
01:30:13,000 --> 01:30:15,480
ALMOST COMPLETELY CONSTANT

2107
01:30:15,480 --> 01:30:17,080
AMAZINGLY ENOUGH BUT NUMBER OF

2108
01:30:17,080 --> 01:30:19,800
APPLICANTS FOR THOSE AWARDS KEPT

2109
01:30:19,800 --> 01:30:21,080
RIDING AND IS CONTINUING TO

2110
01:30:21,080 --> 01:30:26,080
RISE. SO H IS PHENOMENON WE

2111
01:30:26,080 --> 01:30:28,280
LABOR HYPERCOMPETITION. THERE'S

2112
01:30:28,280 --> 01:30:28,880
NUMBER OF REACTIONS TO THE NIH

2113
01:30:28,880 --> 01:30:32,920
POLICY.LY SHOW A COUPLE OF THEM 

2114
01:30:32,920 --> 01:30:34,800
THIS IS HIGH LEVEL PAPER BY

2115
01:30:34,800 --> 01:30:39,240
BRUCE ALBERTS AND MARK SHOWING

2116
01:30:39,240 --> 01:30:40,120
TELEGRAM AND HAROLD VARMUS AND

2117
01:30:40,120 --> 01:30:42,000
THE VOTE IS AGENCIES SHOULD BE

2118
01:30:42,000 --> 01:30:43,400
SENSITIVE TO TOTAL NUMBER OF

2119
01:30:43,400 --> 01:30:44,880
DOLLARS GRANTED TO INDIVIDUAL

2120
01:30:44,880 --> 01:30:46,640
LABS THOUGH DIFFERENT RESEARCH

2121
01:30:46,640 --> 01:30:47,880
ACTIVITIES HAVE DIFFERENT COSTS.

2122
01:30:47,880 --> 01:30:49,040
I WILL TALK ABOUT THAT POINT IN

2123
01:30:49,040 --> 01:30:51,840
A MINUTE. AT SOME POINT RETURNS

2124
01:30:51,840 --> 01:30:54,160
FOR DOLLAR DIMINISHED. WE

2125
01:30:54,160 --> 01:30:56,640
APPLAUD THE DECISION FROM NIH TO

2126
01:30:56,640 --> 01:30:59,680
EXAMINE GRANT PORTFOLIOS DIRECT

2127
01:30:59,680 --> 01:31:01,680
RESEARCH SUPPORT FOR A LAB

2128
01:31:01,680 --> 01:31:03,720
BEYOND 1 MILLION IN DIRECT COSTS

2129
01:31:03,720 --> 01:31:04,920
PER YEAR, ONE OTHER COMMENT THAT

2130
01:31:04,920 --> 01:31:08,120
I'M SHOWING CAME FROM FASEB.

2131
01:31:08,120 --> 01:31:09,360
THEY SAID THAT LIMITING THE

2132
01:31:09,360 --> 01:31:11,680
AMOUNT FUNDING AWARDED TO ANY

2133
01:31:11,680 --> 01:31:13,120
SCIENTIST OR LAB WOULD ENABLE

2134
01:31:13,120 --> 01:31:14,680
MORE PEOPLE, THIS IS THE

2135
01:31:14,680 --> 01:31:15,680
IMPORTANT POINT, ACTIVELY

2136
01:31:15,680 --> 01:31:18,280
ENGAGED IN RESEARCH. NIH

2137
01:31:18,280 --> 01:31:20,360
ANALYSES SHOWED LIMITING PI

2138
01:31:20,360 --> 01:31:23,520
TOTAL RPG, RESEARCH PROJECT

2139
01:31:23,520 --> 01:31:24,720
GRANT, SUPPORT TO 1 MILLION IN

2140
01:31:24,720 --> 01:31:26,840
DIRECT COSTS, WOULD ENABLE THE

2141
01:31:26,840 --> 01:31:29,480
FUNDING OF 2000 ADDITIONAL RPG

2142
01:31:29,480 --> 01:31:32,240
AWARDS AT AN AVERAGE COST OF

2143
01:31:32,240 --> 01:31:33,880
$400,000. NUMBERS TURN OUT ARE A

2144
01:31:33,880 --> 01:31:36,320
LITTLE BIT OFF YEAR BUT NOT --

2145
01:31:36,320 --> 01:31:41,280
APPROXIMATELY CORRECT.  ANOTHER

2146
01:31:41,280 --> 01:31:42,560
CONSIDERATION THAT IS VERY

2147
01:31:42,560 --> 01:31:45,800
IMPORTANT TO WALTER AND REST OF

2148
01:31:45,800 --> 01:31:48,160
US AT NINDS IS THAT INDIVIDUAL

2149
01:31:48,160 --> 01:31:50,400
DEVOTES MINIMAL EFFORT TO

2150
01:31:50,400 --> 01:31:51,760
OVERSEEING A GRANT, I WILL PAUSE

2151
01:31:51,760 --> 01:31:53,560
FOR A SECOND AND TELL YOU THAT

2152
01:31:53,560 --> 01:31:57,280
WE HAVE HAD MANY, MANY

2153
01:31:57,280 --> 01:32:02,160
INVESTIGATORS WHO DEVOTE .8

2154
01:32:02,160 --> 01:32:04,720
CALENDAR MONTHS TO RO1, .6

2155
01:32:04,720 --> 01:32:08,600
CALENDAR MONTHS TO RO1. .8

2156
01:32:08,600 --> 01:32:09,600
CALIBER MONTHS MEANS YOU CAN

2157
01:32:09,600 --> 01:32:13,280
HAVE MORE HAHN 12 RO1s YOU

2158
01:32:13,280 --> 01:32:14,680
OVERSEE. ANY CASE WE BELIEVE

2159
01:32:14,680 --> 01:32:16,600
THAT IF INVESTIGATORS DEVOTING

2160
01:32:16,600 --> 01:32:18,160
MINIMAL AMOUNT TO THE GRANT,

2161
01:32:18,160 --> 01:32:20,200
THAT THE TRAINING AND THE

2162
01:32:20,200 --> 01:32:22,880
MENTORING ENVIRONMENT IN THE LAB

2163
01:32:22,880 --> 01:32:26,200
SUFFERS AND THE THE QUALITY OF

2164
01:32:26,200 --> 01:32:29,080
THE RIGOR DONE IN THE RESEARCH

2165
01:32:29,080 --> 01:32:31,720
LAB ALREADY ALSO SUFFERS SO THIS

2166
01:32:31,720 --> 01:32:32,960
IS ANOTHER ISSUE THAT WE HAVE

2167
01:32:32,960 --> 01:32:36,040
BEEN THINKING ABOUT. SO THE

2168
01:32:36,040 --> 01:32:37,560
NINDS, THE OLD NINDS POLICY

2169
01:32:37,560 --> 01:32:40,280
WHICH WAS APPROVED BY COUNCIL IN

2170
01:32:40,280 --> 01:32:43,120
MANY 2017, AND I WILL SAY THIS

2171
01:32:43,120 --> 01:32:45,520
WAS AFTER MANY LOT OF DISCUSSION

2172
01:32:45,520 --> 01:32:47,280
TWO PREVIOUS COUNCIL MEETINGS.

2173
01:32:47,280 --> 01:32:50,520
APPLIES TO PIs WHOSE NIH

2174
01:32:50,520 --> 01:32:51,960
SUPPORT EXCEEDS 1 MILLION DIRECT

2175
01:32:51,960 --> 01:32:54,360
COSTS, WE INCLUDE THE NEW, THE

2176
01:32:54,360 --> 01:32:55,800
PENDING APPLICATION WHEN

2177
01:32:55,800 --> 01:32:56,960
CALCULATING THAT 1 MILLION IN

2178
01:32:56,960 --> 01:33:00,720
DIRECT COSTS.  WHEN COUNCIL

2179
01:33:00,720 --> 01:33:01,640
DECIDED WAS THAT WE SHOULD

2180
01:33:01,640 --> 01:33:04,040
ESTABLISH A MORE STRINGENT SCR

2181
01:33:04,040 --> 01:33:06,840
PAY LINE WHICH THEY AGREED

2182
01:33:06,840 --> 01:33:08,240
SHOULD BE HALF GENERAL NINDS PAY

2183
01:33:08,240 --> 01:33:11,680
LINE. SO FOR EXAMPLE, NOW

2184
01:33:11,680 --> 01:33:13,800
REGULAR PAY LINE WAS 14

2185
01:33:13,800 --> 01:33:16,520
PERCENTILE, HALF OF THAT IS 7. 

2186
01:33:16,520 --> 01:33:19,320
THIS WAS THE FORMER NINDS SCR

2187
01:33:19,320 --> 01:33:20,560
POLICY THAT WE ARE ABOUT TO

2188
01:33:20,560 --> 01:33:25,240
MODIFY. THE QUESTION, I SHOULD

2189
01:33:25,240 --> 01:33:26,600
MENTION THERE ARE MANY

2190
01:33:26,600 --> 01:33:29,000
EXCEPTIONS TO SCR POLICY, MANY

2191
01:33:29,000 --> 01:33:32,200
OF APPLICATIONS THAT GENERATE

2192
01:33:32,200 --> 01:33:34,960
SCR SCRUTINY DO NOT END UP BEING

2193
01:33:34,960 --> 01:33:36,680
EXEMPTED FROM SCR. I WILL TELL

2194
01:33:36,680 --> 01:33:40,200
YOU WHY. SO FIRST OF ALL WE EXAM

2195
01:33:40,200 --> 01:33:43,720
TRAINING AND CAREER DEVELOPMENT

2196
01:33:43,720 --> 01:33:46,360
APPLICATIONS, F T K, R 13 AND

2197
01:33:46,360 --> 01:33:48,080
RESEARCH RESOURCE APPLICATION. 

2198
01:33:48,080 --> 01:33:49,560
THOSE ARE AUTOMATICALLY EXEMPT

2199
01:33:49,560 --> 01:33:54,360
FROM SCR. THE NEXT TWO

2200
01:33:54,360 --> 01:33:55,920
EXEMPTIONS ARE IMPORTANT ONES.

2201
01:33:55,920 --> 01:33:58,640
WE EXEMPT ANY APPLICATION TO

2202
01:33:58,640 --> 01:34:02,440
INITIATIVE THAT SUPPORTED BY A

2203
01:34:02,440 --> 01:34:03,480
CONGRESSIONALLY DIRECTED FUNDING

2204
01:34:03,480 --> 01:34:05,400
STREAM. I HAVE LISTED SEVERAL OF

2205
01:34:05,400 --> 01:34:08,360
THOSE HERE. BUT THE THINKING IS

2206
01:34:08,360 --> 01:34:12,440
FOR EXAMPLE HEAL IS A NATIONAL

2207
01:34:12,440 --> 01:34:15,040
EMERGENCY AND THAT WE WANT ANY

2208
01:34:15,040 --> 01:34:16,440
INVESTIGATOR TO BE FREE TO APPLY

2209
01:34:16,440 --> 01:34:18,320
TO HEAL. WE DON'T WANT THERE TO

2210
01:34:18,320 --> 01:34:21,920
BE CONSTRAINTS ON THAT. THE

2211
01:34:21,920 --> 01:34:23,320
OTHER THING THAT WE LACK AT

2212
01:34:23,320 --> 01:34:25,280
INDIVIDUALLY, AS POTENTIAL

2213
01:34:25,280 --> 01:34:28,560
EXEMPTION ARE APPLICATIONS OR

2214
01:34:28,560 --> 01:34:29,600
EXISTING GRANTS THAT INVOLVE

2215
01:34:29,600 --> 01:34:31,640
WHAT WE CALL INHERENTLY COSTLY

2216
01:34:31,640 --> 01:34:33,600
RESEARCH. I LISTED DIFFERENT

2217
01:34:33,600 --> 01:34:34,880
TYPES OF SUCH RESEARCH HERE,

2218
01:34:34,880 --> 01:34:36,800
THERE ARE OTHERS FOR EXAMPLE,

2219
01:34:36,800 --> 01:34:40,560
IMAGING STUDIES. INHERENTLY

2220
01:34:40,560 --> 01:34:43,480
COSTLY. SO JUST FOR EXAMPLE, IF

2221
01:34:43,480 --> 01:34:45,840
A PERSON IS THE PI ON CLINICAL

2222
01:34:45,840 --> 01:34:48,520
TRIAL THAT COSTS $3 MILLION A

2223
01:34:48,520 --> 01:34:49,880
YEAR WE DON'T WANT THAT PERSON

2224
01:34:49,880 --> 01:34:52,000
TO BE PROHIBITED FROM GETTING

2225
01:34:52,000 --> 01:34:56,040
ONE RO1 FOR EXAMPLE. Z WE WILL

2226
01:34:56,040 --> 01:34:57,560
SEE AN EXAMPLE OF THIS, IN A

2227
01:34:57,560 --> 01:35:00,440
CLOSED SESSION.  SO SECOND TWO

2228
01:35:00,440 --> 01:35:02,120
BULLETS ARE THE MAIN EXCEPTIONS

2229
01:35:02,120 --> 01:35:04,160
WE TALK ABOUT. WHEN WE ARE

2230
01:35:04,160 --> 01:35:05,880
DECIDING WHO IS NOT SUBJECT TO

2231
01:35:05,880 --> 01:35:11,320
SCR. WHY DO WE -- ARE WE

2232
01:35:11,320 --> 01:35:14,800
CHANGING THIS POLICY, THERE'S

2233
01:35:14,800 --> 01:35:16,760
TWO REASONS. FIRST, THIS CAME AT

2234
01:35:16,760 --> 01:35:19,800
HHS FROM OSTP WHICH IS OFFICE OF

2235
01:35:19,800 --> 01:35:21,600
PRESIDENT SCIENCE ADVISOR.

2236
01:35:21,600 --> 01:35:23,200
TRICKLING DOWN AND IT IS ALSO

2237
01:35:23,200 --> 01:35:25,360
NOW AN INITIATIVE AT NIH, IS

2238
01:35:25,360 --> 01:35:28,320
THAT WE ARE NOW REPLACING NOW

2239
01:35:28,320 --> 01:35:30,480
USING INCREASINGLY TOTAL COSTS

2240
01:35:30,480 --> 01:35:32,280
RATHER THAN DIRECT COSTS, AS A

2241
01:35:32,280 --> 01:35:35,360
FUNDING METRIC.  SO -- THE OTHER

2242
01:35:35,360 --> 01:35:38,360
REASON FOR CHANGING SCR AFTER

2243
01:35:38,360 --> 01:35:40,400
TEN YEARS IS THAT OBVIOUSLY

2244
01:35:40,400 --> 01:35:42,600
THERE'S BEEN INFLATION, IT COSTS

2245
01:35:42,600 --> 01:35:46,640
MORE TO DO RESEARCH. HERE IN A

2246
01:35:46,640 --> 01:35:48,360
NUTSHELL IS NEW NIH WIDE POLICY

2247
01:35:48,360 --> 01:35:51,120
AND THE ONLY THING THAT CHANGES

2248
01:35:51,120 --> 01:35:54,120
IS THE SCR THRESHOLD INSTEAD OF

2249
01:35:54,120 --> 01:35:57,120
BEING 1 MILLION IN DIRECT COSTS

2250
01:35:57,120 --> 01:35:59,160
IS NOW INCREASED TO 2 MILLION

2251
01:35:59,160 --> 01:36:02,240
TOTAL COST. LET ME EXPLAIN FOR A

2252
01:36:02,240 --> 01:36:03,520
MINUTE, 1 MILLION IN DIRECT

2253
01:36:03,520 --> 01:36:06,040
COSTS IS APPROXIMATELY

2254
01:36:06,040 --> 01:36:09,280
1.5 MILLION IN TOTAL COSTS. THE

2255
01:36:09,280 --> 01:36:10,800
AVERAGE NOW JACKHAMMER STARTED

2256
01:36:10,800 --> 01:36:12,360
OUTSIDE MY WINDOW. THE AVERAGE

2257
01:36:12,360 --> 01:36:14,720
INDIRECT COST IS ROUGHLY 50%,

2258
01:36:14,720 --> 01:36:16,480
ACTUALLY A LITTLE BIT LESS. SO 1

2259
01:36:16,480 --> 01:36:19,280
MILLION IN DIRECT COST IS ABOUT

2260
01:36:19,280 --> 01:36:21,120
1.5 MILLION TOTAL. OR

2261
01:36:21,120 --> 01:36:22,880
CONVERSELY, 2 MILLION IN TOTAL

2262
01:36:22,880 --> 01:36:28,120
COSTS IS APPROXIMATELY

2263
01:36:28,120 --> 01:36:29,880
1.3 MILLION DIRECT COST. SO THIS

2264
01:36:29,880 --> 01:36:31,800
IS A SIGNIFICANT INCREASE IN THE

2265
01:36:31,800 --> 01:36:36,840
SCR THRESHOLD. WHAT WE ARE

2266
01:36:36,840 --> 01:36:40,120
PROPOSING IS SIMPLY TO USE THAT

2267
01:36:40,120 --> 01:36:42,200
SAME NIH METRIC INCREASE OUR

2268
01:36:42,200 --> 01:36:43,800
THRESHOLD FROM 1 MILLION DIRECT

2269
01:36:43,800 --> 01:36:47,440
COST TO 2 MILLION TOTAL. AS

2270
01:36:47,440 --> 01:36:48,400
BEFORE CONTINUE TO INCLUDE THE

2271
01:36:48,400 --> 01:36:51,440
NEW OR PENDING APPLICATION. WHEN

2272
01:36:51,440 --> 01:36:52,720
MAKING THAT COMMUTATION.  ALL

2273
01:36:52,720 --> 01:36:54,680
THE OTHER PARAMETERS INCLUDING

2274
01:36:54,680 --> 01:36:56,960
EXCEPTIONS I JUST TALK ABOUT ARE

2275
01:36:56,960 --> 01:37:00,600
REMAINING THE SAME. THIS IS THE

2276
01:37:00,600 --> 01:37:03,640
PROPOSAL. LET ME JUST SHOW YOU A

2277
01:37:03,640 --> 01:37:07,720
FEW FUNDING CONSIDERATIONS HERE 

2278
01:37:07,720 --> 01:37:11,400
OUR PREVIOUS NINDS SCR POLICY

2279
01:37:11,400 --> 01:37:13,320
SAVED US, IN OTHER WORDS BY

2280
01:37:13,320 --> 01:37:15,160
APPLICATIONS THAT DIDN'T GET

2281
01:37:15,160 --> 01:37:17,360
FUNDED, ON THE AVERAGE ROUGHLY

2282
01:37:17,360 --> 01:37:19,840
6.3 MILLION A YEAR. THIS

2283
01:37:19,840 --> 01:37:21,960
COMPUTATION WAS DONE ACROSS THE

2284
01:37:21,960 --> 01:37:24,520
LAST SIX COUNCIL ROUNDS FOR

2285
01:37:24,520 --> 01:37:27,800
NINDS. THE PROPOSE NEW POLICY IF

2286
01:37:27,800 --> 01:37:30,320
YOU LOOK RETRO ACTIVELY WOULD

2287
01:37:30,320 --> 01:37:31,440
SAVE SIGNIFICANTLY LESS

2288
01:37:31,440 --> 01:37:32,640
OBVIOUSLY BECAUSE THE SCR

2289
01:37:32,640 --> 01:37:35,200
THRESHOLD IS NOW HIGHER. 2

2290
01:37:35,200 --> 01:37:36,680
MILLION TOTAL COSTS, WOULD HAVE

2291
01:37:36,680 --> 01:37:39,400
SAVED US ABOUT 3.8 MILLION. SO

2292
01:37:39,400 --> 01:37:42,360
IN A SENSE IT IS COSTING US

2293
01:37:42,360 --> 01:37:44,480
2.5 MILLION PER YEAR. BY THE

2294
01:37:44,480 --> 01:37:48,440
WAY, THESE ARE NOT GIGANTIC SUMS

2295
01:37:48,440 --> 01:37:49,280
OF MONEY, TIM, DO YOU HAVE A

2296
01:37:49,280 --> 01:37:51,760
QUESTION?

2297
01:37:51,760 --> 01:37:53,120
>> PEOPLE IN THE CHAT ARE
SAYING

2298
01:37:53,120 --> 01:37:55,440
THE SAME THING BUT IT WAS

2299
01:37:55,440 --> 01:37:58,200
RELATED TO GOING TO DIRECT TOTAL

2300
01:37:58,200 --> 01:38:01,520
COST, COMMENT ABOUT HOW THE FACT

2301
01:38:01,520 --> 01:38:03,160
THAT WHAT MY INSTITUTION DECIDES

2302
01:38:03,160 --> 01:38:05,480
IS NEGOTIATED INDIRECT COST RATE

2303
01:38:05,480 --> 01:38:08,080
IS UNRELATED TO MY SCIENCE OR

2304
01:38:08,080 --> 01:38:09,280
QUALITY ANYTHING HOW MUCH MONEY

2305
01:38:09,280 --> 01:38:10,760
RAISED BUT WHAT MY INSTITUTION

2306
01:38:10,760 --> 01:38:13,160
CHARGES IS MORE THAN 50%, IT IS

2307
01:38:13,160 --> 01:38:15,240
LOT LESS THAN SOME OTHER PLACE

2308
01:38:15,240 --> 01:38:17,120
THAT CHARGES CLOSE TO 100 SO

2309
01:38:17,120 --> 01:38:20,120
WORRIED ABOUT IT BEING A TOTAL

2310
01:38:20,120 --> 01:38:22,920
COST IS PUNISHING THE INDIVIDUAL

2311
01:38:22,920 --> 01:38:25,400
BASED ON WHO THEY HAPPEN TO WORK

2312
01:38:25,400 --> 01:38:25,680
FOR.

2313
01:38:25,680 --> 01:38:29,160
>> THIS IS ABSOLUTELY
TRUE.

2314
01:38:29,160 --> 01:38:31,720
PERSONALLY I RAISE THIS POINT

2315
01:38:31,720 --> 01:38:33,480
EXTREMELY LOUDLY AT MULTIPLE

2316
01:38:33,480 --> 01:38:34,760
JUNCTURE BEFORE THE POLICY WAS

2317
01:38:34,760 --> 01:38:37,600
ADOPTED. IF YOU INTRODUCE

2318
01:38:37,600 --> 01:38:38,840
INSTITUTION WITH INDIRECT COST

2319
01:38:38,840 --> 01:38:41,920
RATE IS 90%, THERE AREICALLY --

2320
01:38:41,920 --> 01:38:43,880
PLENTY OF HIGH VISIBILITY

2321
01:38:43,880 --> 01:38:46,280
INSTITUTIONS WITH THAT.

2322
01:38:46,280 --> 01:38:47,640
OBVIOUSLY GOING BY TOTAL COST

2323
01:38:47,640 --> 01:38:50,320
YOU ARE AT EXTREME DISADVANTAGE.

2324
01:38:50,320 --> 01:38:52,320
OVER INSTITUTION THAT HAS A 30%

2325
01:38:52,320 --> 01:38:54,680
IN DIRECT -- INDIRECT COST RATE 

2326
01:38:54,680 --> 01:38:56,280
THIS IS TRUE, WE ARE MOVING WITH

2327
01:38:56,280 --> 01:38:58,680
THIS ANYWAY. THIS CAME DOWN FROM

2328
01:38:58,680 --> 01:39:02,040
ABOVE. THIS IS NOT AN NINDS

2329
01:39:02,040 --> 01:39:03,400
DECISION. HOPEFULLY THE FACT

2330
01:39:03,400 --> 01:39:07,600
THAT WE ARE INCREASING DOLLAR

2331
01:39:07,600 --> 01:39:09,320
AMOUNT WILL HELP, THAT IS ONE OF

2332
01:39:09,320 --> 01:39:12,480
THE REASONS THAT NIH CENTRAL

2333
01:39:12,480 --> 01:39:14,080
CHOSE INCREASE THE DOLLAR AMOUNT

2334
01:39:14,080 --> 01:39:17,360
BY 50% IN TERMS OF TOTAL COST,

2335
01:39:17,360 --> 01:39:20,280
BECAUSE EXACTLY THAT POTENTIAL

2336
01:39:20,280 --> 01:39:22,360
FOR BLOW BACK. YOUR POINT IS

2337
01:39:22,360 --> 01:39:24,520
ABSOLUTELY CORRECT. I'M NOT

2338
01:39:24,520 --> 01:39:26,360
GOING TO ARGUE WITH IT. 

2339
01:39:26,360 --> 01:39:27,160
>> OKAY.

2340
01:39:27,160 --> 01:39:29,880
>> I CANNOT SEE THE CHAT
SO ANY

2341
01:39:29,880 --> 01:39:31,560
QUESTIONS FOR ME WILL SAVE UNTIL

2342
01:39:31,560 --> 01:39:33,440
I'M DONE WHICH IS IN ABOUT THREE

2343
01:39:33,440 --> 01:39:37,720
MINUTES.  TO CONTINUE HERE THERE

2344
01:39:37,720 --> 01:39:40,280
IS NOT A ONE ON ONE MAPPING HERE

2345
01:39:40,280 --> 01:39:43,320
BUT FUNDS GENERATED THROUGH SCR,

2346
01:39:43,320 --> 01:39:47,440
THESE EXTRA DOLLARS USED TO

2347
01:39:47,440 --> 01:39:48,680
MAINTAIN WHEN WE CAN INCREASE

2348
01:39:48,680 --> 01:39:50,040
THE PAY LINE, THEY ALSO CAN BE

2349
01:39:50,040 --> 01:39:53,080
USED TO PROMOTE A MORE DIVERSE

2350
01:39:53,080 --> 01:39:54,600
WORK FORCE IN THE PROD SENSE OF

2351
01:39:54,600 --> 01:39:57,320
THE WORD. FOR EXAMPLE MORE EARLY

2352
01:39:57,320 --> 01:39:59,760
STAGE INVESTIGATORS, WE SPENT

2353
01:39:59,760 --> 01:40:01,520
MONEY FUNDING THEM BEYOND THE

2354
01:40:01,520 --> 01:40:04,120
PAY LINE. AND INDIVIDUALS WITH

2355
01:40:04,120 --> 01:40:05,680
DIVERSE SCIENTIFIC PERSPECTIVES

2356
01:40:05,680 --> 01:40:07,600
AND VULNERABLE INVESTIGATORS.

2357
01:40:07,600 --> 01:40:08,840
VULNERABLE INVESTIGATORS IS A

2358
01:40:08,840 --> 01:40:10,400
PERSON IF THEY LOSE THEIR GRANT

2359
01:40:10,400 --> 01:40:12,520
WILL HAVE ESSENTIALLY NO MONEY,

2360
01:40:12,520 --> 01:40:14,840
LIGHTLY OVERSIMPLIFIED. SO THE

2361
01:40:14,840 --> 01:40:18,480
LAST THING I'M GOING TO SHOW YOU

2362
01:40:18,480 --> 01:40:20,840
THESE ARE JUST TWO SCENARIOS,

2363
01:40:20,840 --> 01:40:23,920
THIS WAS OUR OLD NINDS POLICY I

2364
01:40:23,920 --> 01:40:27,400
EXPLAINED TO YOU, 7% SCR PAY

2365
01:40:27,400 --> 01:40:29,280
LINE. THIS IS THE NEW POLICY

2366
01:40:29,280 --> 01:40:31,720
THAT I'M PROPOSING. WE DID, IT

2367
01:40:31,720 --> 01:40:34,960
IS A LITTLE EASIER TO CALCULATE

2368
01:40:34,960 --> 01:40:38,280
AN INVESTIGATORS EXISTING

2369
01:40:38,280 --> 01:40:40,600
SUPPORT THAN IT IS TO CALCULATE

2370
01:40:40,600 --> 01:40:42,880
PENDING GRANT. SOMETIMES STUDY

2371
01:40:42,880 --> 01:40:44,680
SECTION ASKED US TO MODIFY THE

2372
01:40:44,680 --> 01:40:46,680
BUDGET WE DO ADMINISTRATIVE

2373
01:40:46,680 --> 01:40:48,120
CUTS, WE ARE EXPLORING THE

2374
01:40:48,120 --> 01:40:51,960
POSSIBILITY OF DOING THIS NOT

2375
01:40:51,960 --> 01:40:52,960
INCLUDING THE PENNING

2376
01:40:52,960 --> 01:40:55,840
APPLICATION. WE HAD VARIOUS

2377
01:40:55,840 --> 01:40:57,480
SCENARIOS. THE FIRST WAS 2

2378
01:40:57,480 --> 01:40:58,880
MILLION TOTAL COSTS, WHICH IS

2379
01:40:58,880 --> 01:41:01,080
NOT INCLUDING THE PENDING, THIS

2380
01:41:01,080 --> 01:41:02,600
IS THE GENERAL NIH POLICY. THERE

2381
01:41:02,600 --> 01:41:03,800
ARE OTHER INSTITUTES THAT HAVE

2382
01:41:03,800 --> 01:41:07,600
MORE STRINGENT POLICIES. NIGMS

2383
01:41:07,600 --> 01:41:09,200
IS IN THE SAME BALLPARK THAT WE

2384
01:41:09,200 --> 01:41:15,000
ARE IN TERMS OF IN EFFECT CAMPUS

2385
01:41:15,000 --> 01:41:17,400
SAME AS OURS. DOING THIS NOT

2386
01:41:17,400 --> 01:41:18,680
ONLY PENDING DECREASE THE

2387
01:41:18,680 --> 01:41:22,480
SAVINGS THE 2.2 MILLION, IF WE

2388
01:41:22,480 --> 01:41:23,960
DECIDED TO NOT INCLUDE THE

2389
01:41:23,960 --> 01:41:26,320
PENDING BUT TO MAKE UP FOR IT TO

2390
01:41:26,320 --> 01:41:30,880
LOWER THE TOTAL COST, THIS WOULD

2391
01:41:30,880 --> 01:41:32,800
ESSENTIALLY BE ABOUT 1 MILLION

2392
01:41:32,800 --> 01:41:35,320
DIRECT COST. SO MORE LIKE OUR --

2393
01:41:35,320 --> 01:41:37,600
POLICY, DECIDED TO DO THIS, THE

2394
01:41:37,600 --> 01:41:40,120
SAVINGS WOULD OBVIOUSLY GO UP.

2395
01:41:40,120 --> 01:41:41,720
IN FACT ABOVE WHAT WE ARE

2396
01:41:41,720 --> 01:41:44,160
PROPOSING.  AND THEN WE ALSO

2397
01:41:44,160 --> 01:41:46,200
DABBLE WITH THE IDEA OF HAVING A

2398
01:41:46,200 --> 01:41:48,960
MORE -- EVEN MORE STRINGENT PAY

2399
01:41:48,960 --> 01:41:50,320
LINE WITH OTHER INSTITUTES DO

2400
01:41:50,320 --> 01:41:52,400
FOR EXAMPLE, PROGRAM PROJECT

2401
01:41:52,400 --> 01:41:53,720
GRANTS AND OTHER BIG GRANTS. SO

2402
01:41:53,720 --> 01:41:58,080
IF WE FIX THE SCR PAY LINE AT

2403
01:41:58,080 --> 01:42:01,080
5TH PERCENTILE, AND THEN WENT

2404
01:42:01,080 --> 01:42:04,760
WITH THE GENERAL NIH POLICY,

2405
01:42:04,760 --> 01:42:06,440
THIS IS ABOUT -- THESE SAVINGS

2406
01:42:06,440 --> 01:42:08,080
ARE NOT HUGE BUT I WILL TELL YOU

2407
01:42:08,080 --> 01:42:11,120
WHEN WE ARE CALCULATING PAY LINE

2408
01:42:11,120 --> 01:42:12,880
WHICH IS GREAT INTEREST TO MANY

2409
01:42:12,880 --> 01:42:17,920
PEOPLE, EVERY BIT HELPS. OKAY.

2410
01:42:17,920 --> 01:42:19,600
BEFORE I STOP AND ASK THE

2411
01:42:19,600 --> 01:42:21,680
QUESTIONS I REALLY WANT TO THANK

2412
01:42:21,680 --> 01:42:25,080
BRIAN HAUGEN, THE HEAD OF OUR

2413
01:42:25,080 --> 01:42:29,160
ANALYSIS BRANCH AND ALSO ALISA

2414
01:42:29,160 --> 01:42:30,640
SHAVER IN MY OFFICE FOR DOING

2415
01:42:30,640 --> 01:42:32,480
THE CALCULATION US SHOWED YOU

2416
01:42:32,480 --> 01:42:33,400
THESE INVOLVE EVERY SINGLE GRANT

2417
01:42:33,400 --> 01:42:35,880
THAT WAS NOT FUNDED IN COMPUTING

2418
01:42:35,880 --> 01:42:37,320
THE SAVINGS. WHICH WASN'T

2419
01:42:37,320 --> 01:42:42,320
TRIVIAL. YOU CAN ASK ANY

2420
01:42:42,320 --> 01:42:43,720
QUESTIONS YOU WANT AT THIS

2421
01:42:43,720 --> 01:42:45,520
POINT. SOME QUESTIONS WE THINK

2422
01:42:45,520 --> 01:42:48,800
ABOUT HOW TO CREATE INCREASE

2423
01:42:48,800 --> 01:42:49,320
AWARENESS OF SCIENTIFIC

2424
01:42:49,320 --> 01:42:53,080
COMMUNITY. TO SCR BUT PEOPLE

2425
01:42:53,080 --> 01:42:56,040
DON'T KNOW THE NIH POLICY, DON'T

2426
01:42:56,040 --> 01:42:57,960
KNOW OUR POLICY PENDING

2427
01:42:57,960 --> 01:42:59,400
APPLICATION AND WE EVEN THOUGHT

2428
01:42:59,400 --> 01:43:02,480
OF REACHING TO PIs BEFORE THEY

2429
01:43:02,480 --> 01:43:03,920
WRITE GRANT APPLICATIONS THAT

2430
01:43:03,920 --> 01:43:06,600
MIGHT TRIGGER SCR, WHICH IS NOT

2431
01:43:06,600 --> 01:43:08,280
EASY TO DO BUT IT IS UNFORTUNATE

2432
01:43:08,280 --> 01:43:10,480
A PERSON WRITES A GRANT

2433
01:43:10,480 --> 01:43:11,640
APPLICATION TO NINDS AND

2434
01:43:11,640 --> 01:43:14,640
REALIZES THEY HAVE TO GET 7TH

2435
01:43:14,640 --> 01:43:15,920
PERCENTILE TO BE FUNDED. THEN

2436
01:43:15,920 --> 01:43:17,280
THERE IS A QUESTION IS THERE ANY

2437
01:43:17,280 --> 01:43:19,840
TARGETED USE THAT WE COULD HAVE

2438
01:43:19,840 --> 01:43:24,080
OF THE SCR SAVINGS. MORE

2439
01:43:24,080 --> 01:43:25,960
IMPORTANT HAHN THESE TWO BULLETS

2440
01:43:25,960 --> 01:43:28,000
AS ANYTHING ELSE YOU WANT TO ASK

2441
01:43:28,000 --> 01:43:31,320
ABOUT. SO WHY DON'T WE TAKE DOWN

2442
01:43:31,320 --> 01:43:33,000
THE SLIDES, THAT WILL GIVE ME A

2443
01:43:33,000 --> 01:43:34,360
CHANCE TO MORE EASILY LOOK AT

2444
01:43:34,360 --> 01:43:41,240
THE CHAT. SOMEBODY TAKE DOWN THE

2445
01:43:41,240 --> 01:43:43,280
SLIDES? I CAN STOP -- LET'S SEE 

2446
01:43:43,280 --> 01:43:49,040
I CAN STOP SHARING MY SCREEN. I

2447
01:43:49,040 --> 01:43:54,160
WILL STOP THE SHARE.  OKAY. I

2448
01:43:54,160 --> 01:43:59,360
WENT THROUGH THAT QUICKLY. GINA,

2449
01:43:59,360 --> 01:44:01,760
YOU HAVE A QUESTION?

2450
01:44:01,760 --> 01:44:03,240
>> TO ANSWER THE LAST
BULLET

2451
01:44:03,240 --> 01:44:04,600
POINT WHICH IS HOW SHOULD THE

2452
01:44:04,600 --> 01:44:06,720
FUNDS -- THE SAVINGS BE USED.  I

2453
01:44:06,720 --> 01:44:09,720
THINK SINCE THE IDEA IS TO

2454
01:44:09,720 --> 01:44:11,960
DIVERSIFY THE VOICES AND

2455
01:44:11,960 --> 01:44:14,600
INCREASE THE NUMBER OF VOICES IN

2456
01:44:14,600 --> 01:44:15,280
SCIENCE, THAT IS HOW THE FUNDS

2457
01:44:15,280 --> 01:44:18,280
SHOULD BE USED. THAT IS THROUGH

2458
01:44:18,280 --> 01:44:21,640
DECREASING OR INCREASING THE PAY

2459
01:44:21,640 --> 01:44:22,840
LINE OR PROBABLY BETTER WITH

2460
01:44:22,840 --> 01:44:24,320
EARLY STAGE INVESTIGATORS, ET

2461
01:44:24,320 --> 01:44:26,520
CETERA.  THAT YOU SUGGESTED ARE

2462
01:44:26,520 --> 01:44:28,000
BEING DONE ALREADY. I THINK THAT

2463
01:44:28,000 --> 01:44:30,080
IS A GREAT USE FOR IT.

2464
01:44:30,080 --> 01:44:31,520
>> YES, SO ONE THING YOU
SHOULD

2465
01:44:31,520 --> 01:44:33,080
UNDERSTAND, THAT IS A GREAT

2466
01:44:33,080 --> 01:44:36,240
POINT. IS THAT EVERY YEAR WE --

2467
01:44:36,240 --> 01:44:37,520
AS YOU HAVE SEEN IN CLOSED

2468
01:44:37,520 --> 01:44:39,560
SESSION WE SET ASIDE CERTAIN

2469
01:44:39,560 --> 01:44:41,120
DOLLARS TO FUND PEOPLE BEYOND

2470
01:44:41,120 --> 01:44:43,280
THE PAY LINE FOR THINGS LIKE

2471
01:44:43,280 --> 01:44:45,200
HIGH PROGRAM PRIORITY

2472
01:44:45,200 --> 01:44:46,120
APPLICATIONS. ONE OF THE

2473
01:44:46,120 --> 01:44:48,360
CRITERIA FOR THAT IS BRINGING

2474
01:44:48,360 --> 01:44:50,160
DIVERSE SCIENTIFIC PERSPECTIVES

2475
01:44:50,160 --> 01:44:53,000
INTO THE WORKPLACE.  WE GIVE

2476
01:44:53,000 --> 01:44:54,480
BRIDGE AWARDS AND LIKE I SAID WE

2477
01:44:54,480 --> 01:44:57,800
PUT IN ESI. WE COULD MAKE AN

2478
01:44:57,800 --> 01:45:00,720
ATTEMPT TO TARGET ANY OF THE

2479
01:45:00,720 --> 01:45:02,120
SAVINGS TOWARD THOSE USES BUT

2480
01:45:02,120 --> 01:45:06,240
WALTER WILL NEVER ALLOW THOSE TO

2481
01:45:06,240 --> 01:45:08,840
GO BEYOND CERTAIN FLOOR BECAUSE

2482
01:45:08,840 --> 01:45:12,400
HE IS COMMITTED TO THE KINDS OF

2483
01:45:12,400 --> 01:45:15,600
USES I WAS TALKING ABOUT FOR

2484
01:45:15,600 --> 01:45:16,000
HTP.

2485
01:45:16,000 --> 01:45:18,960
>> YOU HAVE THE ECHO THERE

2486
01:45:18,960 --> 01:45:19,440
WALTER.

2487
01:45:19,440 --> 01:45:21,560
>> WE DON'T WANT TO BE
BEHOLDEN

2488
01:45:21,560 --> 01:45:22,640
TO HOW MUCH EXTRA MONEY WE HAVE

2489
01:45:22,640 --> 01:45:24,320
TO DO WHAT WE NEED TO DO. WE ARE

2490
01:45:24,320 --> 01:45:26,560
GOING TO DO WHAT WE NEED TO DO

2491
01:45:26,560 --> 01:45:28,760
NO MATTER WHAT BUT AS BOB SAID

2492
01:45:28,760 --> 01:45:29,400
EVERY LITTLE BIT HELPS.

2493
01:45:29,400 --> 01:45:31,240
>> WE CAN DO WHAT WE NEED
TO DO,

2494
01:45:31,240 --> 01:45:32,720
WE CAN DO MORE THAN WHAT WE NEED

2495
01:45:32,720 --> 01:45:34,200
TO DO WITH THE EXTRA MONEY AS

2496
01:45:34,200 --> 01:45:36,120
WELL. SO THERE ARE A NUMBER OF

2497
01:45:36,120 --> 01:45:37,480
PROGRAM DIRECTORS WHO WOULD LOVE

2498
01:45:37,480 --> 01:45:40,760
TO HAVE THE HTP DOLLARS

2499
01:45:40,760 --> 01:45:41,760
OUTFITTED TO THAT INCREASE SO

2500
01:45:41,760 --> 01:45:43,920
THEY CAN FUND FOR EXAMPLE

2501
01:45:43,920 --> 01:45:45,400
VULNERABLE INVESTIGATORS OR

2502
01:45:45,400 --> 01:45:47,320
INVESTIGATORS WHO ARE DOING

2503
01:45:47,320 --> 01:45:48,600
THINGS THEY THINK IS IMPORTANT.

2504
01:45:48,600 --> 01:45:52,240
DR. RYAN.

2505
01:45:52,240 --> 01:45:53,440
>> HOW MANY GRANTS DOES
THIS

2506
01:45:53,440 --> 01:45:55,640
APPLY TO PER YEAR AT NINDS?

2507
01:45:55,640 --> 01:45:58,800
>> THE ANSWER IS THAT IT
APPLIES

2508
01:45:58,800 --> 01:46:00,680
TO LARGE NUMBER OF APPLICATIONS,

2509
01:46:00,680 --> 01:46:03,400
HOWEVER THE LARGE MAJORITY OF

2510
01:46:03,400 --> 01:46:04,920
THEM ARE EXEMPT BECAUSE THEY ARE

2511
01:46:04,920 --> 01:46:06,320
EITHER APPLICATIONS TO HEAL,

2512
01:46:06,320 --> 01:46:10,560
BRAIN, ADRD, ET CETERA, ET

2513
01:46:10,560 --> 01:46:10,800
CETERA.

2514
01:46:10,800 --> 01:46:12,520
>> THE ONES THAT AREN'T
EXEMPT

2515
01:46:12,520 --> 01:46:13,360
HOW MANY ARE THERE?

2516
01:46:13,360 --> 01:46:17,600
>> I WILL GIVE AN EXAMPLE,
THIS

2517
01:46:17,600 --> 01:46:19,440
-- THIS WAS AN UNUSUAL ROUND,

2518
01:46:19,440 --> 01:46:21,640
THERE WERE FOUR APPLICATIONS,

2519
01:46:21,640 --> 01:46:22,800
YOU WILL SEE TOMORROW, SUBJECT

2520
01:46:22,800 --> 01:46:24,840
TO SCR AND WE ARE PLANNING ON

2521
01:46:24,840 --> 01:46:27,240
FUNDING ALL OF THEM.  PENDING

2522
01:46:27,240 --> 01:46:28,960
COUNCIL APPROVAL. I THINK I'M

2523
01:46:28,960 --> 01:46:30,680
ALLOWED TO SAY THAT IN OPEN

2524
01:46:30,680 --> 01:46:32,920
SESSION. SO BASICALLY THE NUMBER

2525
01:46:32,920 --> 01:46:34,680
OF GRANTS THAT ARE ACTUALLY ON

2526
01:46:34,680 --> 01:46:36,640
THE TABLE THAT COUNCIL LOOKS AT,

2527
01:46:36,640 --> 01:46:38,120
YOU ARE USING YOUR DISCRETION

2528
01:46:38,120 --> 01:46:40,840
AND TALKING ABOUT IT, IS

2529
01:46:40,840 --> 01:46:43,520
SOMETHING LIKE ALISA CAN JUMP IN

2530
01:46:43,520 --> 01:46:46,320
IF I'M WRONG, 10 TO 15.

2531
01:46:46,320 --> 01:46:47,560
>> PER YEAR.

2532
01:46:47,560 --> 01:46:52,920
>> NO, PER COUNCIL ROUND.
TEN

2533
01:46:52,920 --> 01:46:55,160
PER COUNCIL ROUND. MOST OF THEM,

2534
01:46:55,160 --> 01:46:57,280
MANY -- EVERYTHING PERCENTILE 7

2535
01:46:57,280 --> 01:46:58,360
OR BETTER GETS FUND SOD THAT

2536
01:46:58,360 --> 01:46:59,400
TAKES CARE OF SIGNIFICANT NUMBER

2537
01:46:59,400 --> 01:47:01,680
OF THOSE. APPROXIMATELY HALF OF

2538
01:47:01,680 --> 01:47:03,520
THEM, THE OTHER HALF POTENTIALLY

2539
01:47:03,520 --> 01:47:05,720
DON'T GET FUNDED UNLESS THEY ARE

2540
01:47:05,720 --> 01:47:06,880
DOING INHERENT RESEARCH, ET

2541
01:47:06,880 --> 01:47:08,320
CETERA, ET CETERA.  WHAT IS

2542
01:47:08,320 --> 01:47:12,920
BEHIND YOUR QUESTION?

2543
01:47:12,920 --> 01:47:15,720
>> TWO OR THREE PER COUNC
COUNC.

2544
01:47:15,720 --> 01:47:16,760
>> TWO OR THREE WHAT?

2545
01:47:16,760 --> 01:47:18,960
>> ON AVERAGE.

2546
01:47:18,960 --> 01:47:23,600
>> SO WE SAVE ON THE
AVERAGE

2547
01:47:23,600 --> 01:47:25,760
ABOUT 2 AND A HALF IN THE OLD

2548
01:47:25,760 --> 01:47:27,360
POLICY, TWO AND A HALF MILLION

2549
01:47:27,360 --> 01:47:28,600
DOLLARS PER COUNCIL ROUND. SO

2550
01:47:28,600 --> 01:47:29,720
YOU CAN FIGURE OUT HOW MANY

2551
01:47:29,720 --> 01:47:31,680
GRANTS THAT IS.

2552
01:47:31,680 --> 01:47:35,040
>> I GUESS I WOULD JUST
TRY TO

2553
01:47:35,040 --> 01:47:35,920
PUT ON THE SCALE THE SHEER

2554
01:47:35,920 --> 01:47:37,560
NUMBER OF GRANTS PER COUNCIL

2555
01:47:37,560 --> 01:47:38,960
ROUND BEING CONSIDERED FOR

2556
01:47:38,960 --> 01:47:40,360
FUNDING, THE SHEER NUMBER OF

2557
01:47:40,360 --> 01:47:42,040
DOLLARS WERE APPROVING FOR

2558
01:47:42,040 --> 01:47:43,600
COUNCIL ROUND, THIS IS SORT OF

2559
01:47:43,600 --> 01:47:45,640
-- I REALIZE EVERY PENNY COUNTS

2560
01:47:45,640 --> 01:47:47,240
AND CAN BE USED FOR BETTER. BUT

2561
01:47:47,240 --> 01:47:49,160
WE ARE TALKING ROUND OFF ERRORS

2562
01:47:49,160 --> 01:47:51,200
HERE. AREN'T WE?

2563
01:47:51,200 --> 01:47:53,240
>> ROUND OFF ERRORS BUT
NOT TO

2564
01:47:53,240 --> 01:47:55,120
PEOPLE WHO END UP GETTING

2565
01:47:55,120 --> 01:47:55,600
FUNDING.

2566
01:47:55,600 --> 01:47:56,160
>> OF COURSE.

2567
01:47:56,160 --> 01:47:58,320
>> SO THE AMOUNT WE QUOTE

2568
01:47:58,320 --> 01:48:00,680
UNQUOTE SAVE BY SCR FLUCTUATES

2569
01:48:00,680 --> 01:48:03,040
WILDLY. THERE MIGHT BE A ROUND

2570
01:48:03,040 --> 01:48:04,240
WHERE WE SAVE $4 MILLION, THIS

2571
01:48:04,240 --> 01:48:07,960
IS ONE COUNCIL ROUND I'VE SEEN

2572
01:48:07,960 --> 01:48:09,560
SUCH A ROUND. $4 MILLION IS

2573
01:48:09,560 --> 01:48:11,560
ENOUGH TO FUND A LOT OF RO1s

2574
01:48:11,560 --> 01:48:13,480
OF PEOPLE WHO MIGHT NOT

2575
01:48:13,480 --> 01:48:15,160
OTHERWISE GET RO1. IF YOU ARE

2576
01:48:15,160 --> 01:48:16,960
ANOTHER ONE OF THOSE RO 1ES, IT

2577
01:48:16,960 --> 01:48:17,760
IS A BIG DEAL.

2578
01:48:17,760 --> 01:48:19,240
>> NOT ARGUING WITH THAT,
JUST

2579
01:48:19,240 --> 01:48:20,920
PUTTING THE SCALE, A LOT OF

2580
01:48:20,920 --> 01:48:23,040
THINGS TO PAY ATTENTION TO.

2581
01:48:23,040 --> 01:48:26,760
>> THAT IS THE SCALE I
THINK.

2582
01:48:26,760 --> 01:48:28,360
>> YOU KNOW YOU HAVE BEEN
IN THE

2583
01:48:28,360 --> 01:48:30,920
GOVERNMENT TOO LONG WHEN TWO OR

2584
01:48:30,920 --> 01:48:32,960
THREE MILLION DOLLARS IS CHUMP

2585
01:48:32,960 --> 01:48:33,200
CHANGE.

2586
01:48:33,200 --> 01:48:33,800
>> THAT'S RIGHT. THE LAST
TIME

2587
01:48:33,800 --> 01:48:38,040
WALTER SAID TO ME HE SAID ABOUT

2588
01:48:38,040 --> 01:48:41,720
$1 MILLION. $2 MILLION IS

2589
01:48:41,720 --> 01:48:42,080
NOTHING.

2590
01:48:42,080 --> 01:48:45,680
>> AARON.

2591
01:48:45,680 --> 01:48:49,880
>> TO YOUR QUESTION ABOUT
HOW TO

2592
01:48:49,880 --> 01:48:51,560
ADVERTISE THIS ONE IDEA MIGHT BE

2593
01:48:51,560 --> 01:48:55,080
IF THERE'S SOME WAY TO USE THE

2594
01:48:55,080 --> 01:48:58,600
ERA COMMONS TO JUST SORT OF WHEN

2595
01:48:58,600 --> 01:48:59,920
SOMEONE IS APPLYING FOR A

2596
01:48:59,920 --> 01:49:03,160
PROJECT IF IT CALCULATES THEIR

2597
01:49:03,160 --> 01:49:06,800
OWN TOTAL COSTS AND REPORTS BACK

2598
01:49:06,800 --> 01:49:08,160
TO THEM JUST LIKE WHEN WE ARE

2599
01:49:08,160 --> 01:49:09,400
APPLYING FOR GRANTS WE HAVE TO

2600
01:49:09,400 --> 01:49:11,000
CHECK A BOX IF WE ARE USING

2601
01:49:11,000 --> 01:49:12,920
VERTEBRATE ANIMAL OR STEM CELLS,

2602
01:49:12,920 --> 01:49:15,440
IT CAN BE ANOTHER BOX TO SAY

2603
01:49:15,440 --> 01:49:19,480
THIS IS MY TOTAL COSTS. I

2604
01:49:19,480 --> 01:49:20,920
UNDERSTAND THAT THIS WILL BE

2605
01:49:20,920 --> 01:49:21,760
SUBJECT TO SPECIAL COUNCIL

2606
01:49:21,760 --> 01:49:23,360
REVIEW OR SOMETHING LIKE THAT. 

2607
01:49:23,360 --> 01:49:25,480
>> SO SORT OF AUTOMATIC
WITH

2608
01:49:25,480 --> 01:49:26,120
FEATURES THAT ALREADY KNOW.

2609
01:49:26,120 --> 01:49:27,760
>> I THINK THAT IS A
REALLY GOOD

2610
01:49:27,760 --> 01:49:29,440
IDEAIDEA.  WE TALKED ABOUT THATT

2611
01:49:29,440 --> 01:49:30,760
KEEP IN MIND THIS IS AFTER THE

2612
01:49:30,760 --> 01:49:31,840
PERSON IS ALREADY WRITTEN THE

2613
01:49:31,840 --> 01:49:34,520
APPLICATION. 

2614
01:49:34,520 --> 01:49:37,280
>> OR WHEN THEY ARE
APPLYING. SO

2615
01:49:37,280 --> 01:49:39,600
WHEN THEY -- THE PROPOSAL

2616
01:49:39,600 --> 01:49:42,320
CENTRAL OR WHATEVER PUTTING

2617
01:49:42,320 --> 01:49:44,120
TOGETHER THE APPLICATION.

2618
01:49:44,120 --> 01:49:48,640
>> THAT IS A GOOD IDEA. 
DAVID. 

2619
01:49:48,640 --> 01:49:51,120
>> THANKS. MANY OF US I
THINK

2620
01:49:51,120 --> 01:49:52,400
HAVE BEEN THINKING ABOUT HOW ARE

2621
01:49:52,400 --> 01:49:54,080
WE GOING TO FIND DIVERSITY

2622
01:49:54,080 --> 01:49:55,360
EQUITY AN INCLUSION ACTIVITY T

2623
01:49:55,360 --> 01:49:56,640
AND MANY OF US SPENT TIME

2624
01:49:56,640 --> 01:49:58,680
THINKING ABOUT THE TRAINING

2625
01:49:58,680 --> 01:50:02,000
PROGRAMS AND DOMAIN DIVERSITY

2626
01:50:02,000 --> 01:50:03,800
EQUITY INCLUSION. HOPEFULLY HAVE

2627
01:50:03,800 --> 01:50:05,320
PAPER PRETTY SOON BUT THIS WILL

2628
01:50:05,320 --> 01:50:07,360
BE A PERFECT OPPORTUNITY EXACTLY

2629
01:50:07,360 --> 01:50:09,000
WHERE THE MONEY COULD BE, YOU

2630
01:50:09,000 --> 01:50:10,920
COULD FUND IT SEVERAL MORE RO

2631
01:50:10,920 --> 01:50:14,240
1ES BUT YOU CAN FUND MORE

2632
01:50:14,240 --> 01:50:15,960
GRADUATE SCHOOL STIPENDS OR

2633
01:50:15,960 --> 01:50:17,600
POST-DOCTORAL STIPENDS OR JUNIOR

2634
01:50:17,600 --> 01:50:18,960
FACULTY TRANSITION AWARDS, YOU

2635
01:50:18,960 --> 01:50:22,040
CAN MAKE THE ASSISTAL MONEY GO

2636
01:50:22,040 --> 01:50:23,880
FURTHER IN THAT DOMAIN AND PUT

2637
01:50:23,880 --> 01:50:26,480
MONEY WHERE OUR VALUES ARE.

2638
01:50:26,480 --> 01:50:28,600
>> THAT IS A EXCELLENT
IDEA AND

2639
01:50:28,600 --> 01:50:30,000
I WILL MENTION SOMETHING I TOLD

2640
01:50:30,000 --> 01:50:31,480
WALTER YESTERDAY, OUR STAFF OUR

2641
01:50:31,480 --> 01:50:35,320
PROGRAM DIRECTORS SOME OF THEM

2642
01:50:35,320 --> 01:50:38,160
TOLD ME THESE SCR CALCULATIONS

2643
01:50:38,160 --> 01:50:39,600
INVOLVE WORK BY OUR STAFF. THIS

2644
01:50:39,600 --> 01:50:42,160
IS QUITE COMPLICATED, IF IT IS A

2645
01:50:42,160 --> 01:50:43,520
MULTIPLE PI GRANT HOW MUCH IS

2646
01:50:43,520 --> 01:50:44,480
YOURS, HOW MUCH IS THE OTHER

2647
01:50:44,480 --> 01:50:47,640
PERSON, ET CETERA.  BUT SOME

2648
01:50:47,640 --> 01:50:48,760
STAFF IF WE KNEW THE MONEY WAS

2649
01:50:48,760 --> 01:50:49,840
SPECIFICALLY GOING TO BE

2650
01:50:49,840 --> 01:50:52,280
TARGETED TO SOMETHING REALLY

2651
01:50:52,280 --> 01:50:55,360
GREAT WHY FOR EXAMPLE LIKE DAVID

2652
01:50:55,360 --> 01:50:57,880
SAID PERHAPS INCREASE THEIR

2653
01:50:57,880 --> 01:51:01,040
HAPPINESS LEVEL. TOM.

2654
01:51:01,040 --> 01:51:03,680
>> THESE ARE ALL GREAT
IDEAS AND

2655
01:51:03,680 --> 01:51:07,440
I COULD SEE SUPPORTING DAVID AND

2656
01:51:07,440 --> 01:51:10,200
ESI IDEAS.  I HAD TWO, ONE IS

2657
01:51:10,200 --> 01:51:12,160
GOING TO BE DELIBERATELY

2658
01:51:12,160 --> 01:51:13,160
CONTROVERSIAL. I DON'T

2659
01:51:13,160 --> 01:51:14,720
NECESSARILY SUPPORT IT A WHOLE

2660
01:51:14,720 --> 01:51:16,680
LOT BUT I THINK IT IS WORTH

2661
01:51:16,680 --> 01:51:18,400
CONSIDERING. I THINK WE ALL KNOW

2662
01:51:18,400 --> 01:51:22,680
WHEN WE LOOK AT STUDY SECTION

2663
01:51:22,680 --> 01:51:25,240
REVIEW THAT THERE IS A SMEAR

2664
01:51:25,240 --> 01:51:26,840
BETWEEN THIS IS QUANTIFIED IN A

2665
01:51:26,840 --> 01:51:30,040
WELL KNOWN 2016 ELI PAPER, IF

2666
01:51:30,040 --> 01:51:33,480
YOU LOOK AT IMPACT OF RESEARCH

2667
01:51:33,480 --> 01:51:34,880
PROJECT GRANT, STUDY SECTIONS

2668
01:51:34,880 --> 01:51:38,040
ARE REALLY GOOD AT UNDERSTANDING

2669
01:51:38,040 --> 01:51:39,720
BOTTOM 40%. THEY ARE OKAY

2670
01:51:39,720 --> 01:51:41,600
UNDERSTANDING THE TOP 3% IN

2671
01:51:41,600 --> 01:51:43,040
TERMS OF PUBLICATIONS AND THEN

2672
01:51:43,040 --> 01:51:44,200
THE CITATIONS OF THOSE

2673
01:51:44,200 --> 01:51:47,360
PUBLICATIONS. BUT BETWEEN 3 AND

2674
01:51:47,360 --> 01:51:49,560
20% THERE IS NO SIGNIFICANT

2675
01:51:49,560 --> 01:51:53,600
DIFFERENCE AT ALL. THE OUTPUT OF

2676
01:51:53,600 --> 01:51:56,000
THOSE RESEARCH PROGRAMS. SO THE

2677
01:51:56,000 --> 01:51:58,520
STUDY SECTION IS REALLY

2678
01:51:58,520 --> 01:52:00,600
IMPORTANT AT THAT. SEW ONE IDEA

2679
01:52:00,600 --> 01:52:02,560
IS TO FUND AN EXPERIMENT AND

2680
01:52:02,560 --> 01:52:04,520
THAT IS BETWEEN THE THREE AND

2681
01:52:04,520 --> 01:52:07,320
THE 20% SOMETHING ORTHOGONAL IS

2682
01:52:07,320 --> 01:52:09,960
PUT ON. LIKE A DOUBLE -- LIKE A

2683
01:52:09,960 --> 01:52:11,640
DOUBLE PROTEIN SEPARATION.

2684
01:52:11,640 --> 01:52:13,200
SEPARATE THEM IN ANOTHER

2685
01:52:13,200 --> 01:52:15,240
DIMENSION USING SOME OTHER

2686
01:52:15,240 --> 01:52:18,160
CRITERION TO UNDERSTAND WHO YOU

2687
01:52:18,160 --> 01:52:19,920
MIGHT PICK UP AS ADDITIONAL

2688
01:52:19,920 --> 01:52:21,520
GRANT TO FUND. THIS IS NOW USING

2689
01:52:21,520 --> 01:52:24,120
JUST THE LENS OF IMPACT. JUST

2690
01:52:24,120 --> 01:52:26,440
THINKING IMPACT. IF WE JUST ADD

2691
01:52:26,440 --> 01:52:29,880
A LONGER TAIL EVIDENCE SUGGEST

2692
01:52:29,880 --> 01:52:31,000
WE WON'T NECESSARILY PICK UP

2693
01:52:31,000 --> 01:52:33,000
GREATER IMPACT. SO THAT IS ONE

2694
01:52:33,000 --> 01:52:35,040
IDEA. A SECOND IDEA IS WHEN I

2695
01:52:35,040 --> 01:52:37,080
THINK IT WAS NIDA LOOKED AT

2696
01:52:37,080 --> 01:52:38,320
THIS, THEY LOOKED AT THE

2697
01:52:38,320 --> 01:52:40,200
ULTIMATE SUCCESS OF SOME THEIR

2698
01:52:40,200 --> 01:52:43,080
TRAINEES AND FOUND IT WASN'T ESI

2699
01:52:43,080 --> 01:52:45,040
IS IMPORTANT AND GETS PEOPLE

2700
01:52:45,040 --> 01:52:47,280
INTO THE RACE, IT WAS THE

2701
01:52:47,280 --> 01:52:48,880
RENEWAL THAT MATTERS. WONDERING

2702
01:52:48,880 --> 01:52:52,040
THERE IS SOME CREATIVE WAY TO

2703
01:52:52,040 --> 01:52:54,880
HELP WITH THAT. WITH THE

2704
01:52:54,880 --> 01:52:55,720
RENEWAL. I DON'T KNOW HOW TO DO

2705
01:52:55,720 --> 01:52:57,800
IT BUT IT IS JUST AN IDEA.

2706
01:52:57,800 --> 01:52:59,440
>> IT WAS A POINT WHICH --
WHAT

2707
01:52:59,440 --> 01:53:01,640
YOU ARE SAYING IS EXACTLY ON

2708
01:53:01,640 --> 01:53:03,000
TARGET TOM WITH A LOT OF

2709
01:53:03,000 --> 01:53:06,560
DISCUSSIONS GOING ON. AT ONE

2710
01:53:06,560 --> 01:53:07,880
POINT I'M OLD ENOUGH TO REMEMBER

2711
01:53:07,880 --> 01:53:09,760
THIS, THERE WAS AN NIH

2712
01:53:09,760 --> 01:53:12,200
INITIATIVE TARGETED ON FIRST

2713
01:53:12,200 --> 01:53:14,120
TIME RENEWALS. I HAVE MOST

2714
01:53:14,120 --> 01:53:15,720
DIFFICULT POINT IN MY CAREER IS

2715
01:53:15,720 --> 01:53:17,440
RENEWING MY FIRST RO1, AFTER

2716
01:53:17,440 --> 01:53:19,520
THAT THINGS WERE EASIER. IN

2717
01:53:19,520 --> 01:53:20,800
TERMS OF FIRST THING SAID, THAT

2718
01:53:20,800 --> 01:53:23,760
IS A GOOD SUGGESTION, THERE ARE

2719
01:53:23,760 --> 01:53:26,360
THREE OVERSIMPLIFY THREE

2720
01:53:26,360 --> 01:53:27,760
POSSIBLE FUNDING MODELS, PERHAPS

2721
01:53:27,760 --> 01:53:29,160
WE SHOULD TALK ABOUT THIS IN A

2722
01:53:29,160 --> 01:53:31,320
FUTURE OPEN SESSION. THE FIRST

2723
01:53:31,320 --> 01:53:33,200
IS WHAT NINDS DOES WHICH IS

2724
01:53:33,200 --> 01:53:35,560
USUALLY CALLED THE HARD PAY LINE

2725
01:53:35,560 --> 01:53:37,080
MODEL.  WE FUND RIGHT NOW

2726
01:53:37,080 --> 01:53:38,640
EVERYTHING UP TO THE 14TH

2727
01:53:38,640 --> 01:53:40,240
PERCENTILE AND THEN WALTER SETS

2728
01:53:40,240 --> 01:53:42,440
ASIDE A CHUNK OF MONEY TO FUND

2729
01:53:42,440 --> 01:53:44,800
BEYOND THAT. THE OTHER EXTREME

2730
01:53:44,800 --> 01:53:46,840
IS WHAT NIGMS DOES WHERE THEY

2731
01:53:46,840 --> 01:53:47,600
LOOK AT EVERY GRANT

2732
01:53:47,600 --> 01:53:49,720
INDIVIDUALLY. I DON'T QUITE KNOW

2733
01:53:49,720 --> 01:53:51,680
HOW THEY DO THAT BUT THAT IS

2734
01:53:51,680 --> 01:53:52,920
WHAT THEY DO. THE INTERMEDIATE

2735
01:53:52,920 --> 01:53:55,120
MODEL WHAT NIMH DOES IS SIMILAR

2736
01:53:55,120 --> 01:53:57,600
TO WHAT YOU PROPOSED, TOM, WHICH

2737
01:53:57,600 --> 01:54:00,000
IS SAY THEY HAVE ENOUGH MONEY

2738
01:54:00,000 --> 01:54:01,520
FOR PAY LINE 15 PERCENTILE, THEY

2739
01:54:01,520 --> 01:54:05,080
SET A ZONE FROM 10% TO 20%,

2740
01:54:05,080 --> 01:54:06,240
DECIDE THEY ARE GOING TO FUND

2741
01:54:06,240 --> 01:54:08,520
HALF THE APPLICATIONS IN THAT

2742
01:54:08,520 --> 01:54:10,240
ZONZONE. AND THEN DO A DEEP DIVE

2743
01:54:10,240 --> 01:54:12,000
INTO THOSE APPLICATIONS. TRYING

2744
01:54:12,000 --> 01:54:15,160
TO PICK OUT ONES THAT WE MIGHT

2745
01:54:15,160 --> 01:54:18,440
SKIP BELOW 15 OR FUND BEYOND 15.

2746
01:54:18,440 --> 01:54:19,680
THAT IS NOT EXACTLY WHAT YOU

2747
01:54:19,680 --> 01:54:22,800
WERE SAYING. WE ALSO HAD

2748
01:54:22,800 --> 01:54:24,160
DISCUSSIONS JIM NOT ONE PROGRAM

2749
01:54:24,160 --> 01:54:26,840
DIRECTOR Z HAS DONE ANALYSES OF

2750
01:54:26,840 --> 01:54:28,080
STUDY SECTION IMPRECISION AND

2751
01:54:28,080 --> 01:54:29,480
IMPLICATIONS OF THAT. AND SOME

2752
01:54:29,480 --> 01:54:30,960
FUNDING MODELS THAT MIGHT COME

2753
01:54:30,960 --> 01:54:33,320
OUT OF THAT BUT YOU ARE RIGHT,

2754
01:54:33,320 --> 01:54:36,240
OUR MODEL ADDING A TAIL IS NOT

2755
01:54:36,240 --> 01:54:38,920
THE ONLY POSSIBLE MODEL. I SORT

2756
01:54:38,920 --> 01:54:43,640
OF THAT ADDRESSES WHAT YOU ASK. 

2757
01:54:43,640 --> 01:54:43,840
ALLAN.

2758
01:54:43,840 --> 01:54:45,560
>> I WANT TO GO BACK TO
THE

2759
01:54:45,560 --> 01:54:47,560
BRUCE ALBERT'S PAPER YOU

2760
01:54:47,560 --> 01:54:50,200
MENTIONED. ONE OF THE THINGS

2761
01:54:50,200 --> 01:54:54,480
THAT WAS WRITTEN THERE WAS

2762
01:54:54,480 --> 01:54:55,640
CONCERN IS A GIVEN LAB JUST

2763
01:54:55,640 --> 01:54:57,520
CAN'T GENERATE ALL THAT WORK

2764
01:54:57,520 --> 01:55:02,120
WHEN THEY HAVE SO MUCH MONEY.

2765
01:55:02,120 --> 01:55:04,480
THEY CAN APPOINT 6% EFFORT THAT

2766
01:55:04,480 --> 01:55:06,760
IS RIDICULOUS, I CAN AGREE WITH

2767
01:55:06,760 --> 01:55:09,080
THAT. DOESN'T THAT REALLY -- TWO

2768
01:55:09,080 --> 01:55:10,680
THINGS. I KNOW I'M GOING WHERE I

2769
01:55:10,680 --> 01:55:12,760
SHOULDN'T GO BUT THAT COUNTERS

2770
01:55:12,760 --> 01:55:14,000
THE WHOLE ARGUMENT. BASICALLY

2771
01:55:14,000 --> 01:55:17,680
YOU HAVE ALL THIS MONEY, DOESN'T

2772
01:55:17,680 --> 01:55:19,720
MATTER YOU CAN STILL GET UP TO

2773
01:55:19,720 --> 01:55:20,640
$1 MILLION IN NIH FUNDING NUMBER

2774
01:55:20,640 --> 01:55:23,640
ONE.  THE OTHER RELATED THING

2775
01:55:23,640 --> 01:55:27,320
WHICH IS VERY RELEVANT NINDS ARE

2776
01:55:27,320 --> 01:55:30,000
THE R 35s.  R 35s REQUIRES

2777
01:55:30,000 --> 01:55:32,360
THAT YOU HAVE 50% EFFORT IN

2778
01:55:32,360 --> 01:55:34,880
ORDER TO GET THAT R 35. YOU

2779
01:55:34,880 --> 01:55:39,760
DON'T HAVE TO HAVE 50% EFFORT TO

2780
01:55:39,760 --> 01:55:43,440
GET $500,000 GRANT ON AN RO1.

2781
01:55:43,440 --> 01:55:47,000
YOU CAN PUT 25% YOU CAN PUT 15%.

2782
01:55:47,000 --> 01:55:48,880
I DON'T KNOW WHO LOOKS AT THAT.

2783
01:55:48,880 --> 01:55:50,320
SO AS THE ULTIMATE QUESTION IS

2784
01:55:50,320 --> 01:55:52,760
WHAT IS THE PRODUCTIVITY COMING

2785
01:55:52,760 --> 01:55:55,760
OUT OF ALL THIS MONEY? I DON'T

2786
01:55:55,760 --> 01:55:57,320
KNOW IF EVER LOOK

2787
01:55:57,320 --> 01:55:58,600
RETROSPECTIVELY IN A BLIND WAY

2788
01:55:58,600 --> 01:55:59,640
AND SAY THAT PERSON HAD A

2789
01:55:59,640 --> 01:56:02,280
MILLION DOLLARS, THAT PERSON HAD

2790
01:56:02,280 --> 01:56:02,960
$500,000, WHAT WAS THE

2791
01:56:02,960 --> 01:56:04,720
PRODUCTIVITY THAT GENERATED FROM

2792
01:56:04,720 --> 01:56:06,320
THOSE GROUPS? WAS IT REALLY

2793
01:56:06,320 --> 01:56:07,720
TWICE AS MUCH WITH A MILLION

2794
01:56:07,720 --> 01:56:10,640
DOLLARS? OR WAS IT NOT?

2795
01:56:10,640 --> 01:56:11,800
>> WHAT IS THE BASIS FOR
MAKING

2796
01:56:11,800 --> 01:56:12,960
THESE DECISIONS?

2797
01:56:12,960 --> 01:56:14,840
>> SO FIRST ONE THING IN
TERMS

2798
01:56:14,840 --> 01:56:16,760
OF GOING WHERE YOU SHOULDN'T GO,

2799
01:56:16,760 --> 01:56:18,880
I DEFINITELY DON'T WANT TO START

2800
01:56:18,880 --> 01:56:19,280
RELITIGATE.

2801
01:56:19,280 --> 01:56:20,160
>> OKAY. I'M SORRY.

2802
01:56:20,160 --> 01:56:23,080
>> I HAVE PTSD. WE SPENT
SO MUCH

2803
01:56:23,080 --> 01:56:25,040
TIME AND BY WE I'M TAUGHT

2804
01:56:25,040 --> 01:56:28,160
TALKING NIH DIRECTOR ON THEM.

2805
01:56:28,160 --> 01:56:30,040
DISCUSSING THAT. BUT IN TERMS OF

2806
01:56:30,040 --> 01:56:31,800
WHAT YOU JUST SAID THOSE STUDIES

2807
01:56:31,800 --> 01:56:34,480
HAVE ACTUALLY BEEN DONE IN GREAT

2808
01:56:34,480 --> 01:56:35,360
DETAIL THOUGH SOME PEOPLE

2809
01:56:35,360 --> 01:56:37,120
CHALLENGED THEM. SO I DON'T KNOW

2810
01:56:37,120 --> 01:56:39,720
IF YOU RECALL THAT WHEN OER,

2811
01:56:39,720 --> 01:56:42,320
OFFICE OF EXTRAMURAL RESEARCH,

2812
01:56:42,320 --> 01:56:45,160
NIH OD, IN ADDITION TO

2813
01:56:45,160 --> 01:56:47,240
GENERATING A HYPERCOMPETITION

2814
01:56:47,240 --> 01:56:49,040
THOSE CURVES THAT I SHOWED YOU,

2815
01:56:49,040 --> 01:56:52,640
THEY GENERATED A CURVE ABOUT

2816
01:56:52,640 --> 01:56:53,800
PRODUCTIVITY AGAIN THIS WAS

2817
01:56:53,800 --> 01:56:57,040
USING A VERY POOR MEASURE WHICH

2818
01:56:57,040 --> 01:56:58,640
IS -- IF USE NUMBERS OF PAPERS

2819
01:56:58,640 --> 01:57:01,760
OR IMPACT BACK TO SOMETHING LIKE

2820
01:57:01,760 --> 01:57:03,240
THAT, THOUGH IT WAS DONE BY

2821
01:57:03,240 --> 01:57:04,480
ANOTHER GROUP LOOKING CAREFULLY

2822
01:57:04,480 --> 01:57:08,280
BUT BASICALLY THEY SHOW THERE

2823
01:57:08,280 --> 01:57:10,520
WERE CONTINUALLY DIMINISHING

2824
01:57:10,520 --> 01:57:12,520
RETURNS AMONG -- ABOVE A CERTAIN

2825
01:57:12,520 --> 01:57:13,320
AMOUNT OF MONEY, I DON'T

2826
01:57:13,320 --> 01:57:14,800
REMEMBER THE DETAILS ANY MORE,

2827
01:57:14,800 --> 01:57:17,080
BUT THAT WAS ACTUALLY A FAMOUS

2828
01:57:17,080 --> 01:57:20,720
ANALYSIS MIKE SHOWED BACK THEN

2829
01:57:20,720 --> 01:57:22,240
AND THE ANSWER WAS THAT THEY ARE

2830
01:57:22,240 --> 01:57:26,200
ABOVE SOME THRESHOLD 750,000,

2831
01:57:26,200 --> 01:57:28,000
FORGET WHAT IT WAS T RETURN --

2832
01:57:28,000 --> 01:57:30,640
IN TERMS OF THAT IMPERFECT

2833
01:57:30,640 --> 01:57:33,080
METRIC SHARPLY DECREASE

2834
01:57:33,080 --> 01:57:34,000
COLLABORATORY. THAT IS OBVIOUSLY

2835
01:57:34,000 --> 01:57:35,960
NOT TRUE OF EVERY AND COUNTING

2836
01:57:35,960 --> 01:57:39,040
PAPERS IS OBVIOUSLY A POOR WAY

2837
01:57:39,040 --> 01:57:40,400
DOFFING THINGS BUT -- OF DOING

2838
01:57:40,400 --> 01:57:41,720
THINGS BUT THOSE STUDIES HAVE

2839
01:57:41,720 --> 01:57:43,520
BEEN DONE AND USED TO SUGGEST A

2840
01:57:43,520 --> 01:57:46,160
CASE INITIALLY FOR SCR PROCESS.

2841
01:57:46,160 --> 01:57:47,040
WHAT EVERYONE THINKS OF THOSE

2842
01:57:47,040 --> 01:57:47,760
STUDIES. 

2843
01:57:47,760 --> 01:57:49,760
>> WHAT ABOUT THE R 35
ISSUE?

2844
01:57:49,760 --> 01:57:52,320
50%?

2845
01:57:52,320 --> 01:57:53,360
>> WHAT IS THE QUESTION?

2846
01:57:53,360 --> 01:57:55,360
>> THERE IS A MINIMUM. YOU
HAVE

2847
01:57:55,360 --> 01:57:59,120
TO PUT 50% AND MAYBE YOU CAN --

2848
01:57:59,120 --> 01:58:00,880
YOU CAN GET POSSIBLY $300,000 A

2849
01:58:00,880 --> 01:58:04,040
YEAR, MAYBE $500,000 A YEAR AND

2850
01:58:04,040 --> 01:58:07,600
YET YOU CAN PUT AN RO1 IN AT

2851
01:58:07,600 --> 01:58:09,040
$500,000 BECAUSE NOBODY GOES IN

2852
01:58:09,040 --> 01:58:11,160
MODULAR AND PUT IT IN 10% OR

2853
01:58:11,160 --> 01:58:11,600
15%.

2854
01:58:11,600 --> 01:58:15,200
>> HERE IS THE CRITICAL
FEATURE.

2855
01:58:15,200 --> 01:58:16,480
WHICH IS WHAT YOU ARE SAYING IS

2856
01:58:16,480 --> 01:58:18,160
ABSOLUTELY TRUE BUT CRITICAL

2857
01:58:18,160 --> 01:58:19,360
POINT IS INVESTIGATOR CHOOSES

2858
01:58:19,360 --> 01:58:21,640
WHETHER TO HAVE AN RO1 OR AN R

2859
01:58:21,640 --> 01:58:23,320
35. SO MOST PEOPLE WHEN THEY

2860
01:58:23,320 --> 01:58:25,880
SUBMIT AN R 35 APPLICATION

2861
01:58:25,880 --> 01:58:27,120
ALLOWED TO DO THIS SUBMIT FOR

2862
01:58:27,120 --> 01:58:29,280
EXAMPLE AN OVERLAPPING RO1 OR

2863
01:58:29,280 --> 01:58:31,040
MULTIPLE OVERLAPPING RO1s,

2864
01:58:31,040 --> 01:58:32,200
THERE ARE QUITE A FEW

2865
01:58:32,200 --> 01:58:34,600
INVESTIGATORS WHO ARE -- WHO

2866
01:58:34,600 --> 01:58:37,280
PUTTING 50% EFFORT ON FOR

2867
01:58:37,280 --> 01:58:38,880
EXAMPLE 350,000, THAT'S THE

2868
01:58:38,880 --> 01:58:40,480
MINIMUM R 35 AMOUNT, GRANT, THAT

2869
01:58:40,480 --> 01:58:41,840
I DON'T WANT TO DO THAT. THEY

2870
01:58:41,840 --> 01:58:44,080
DON'T WANT TO TIE UP 50% EFFORT

2871
01:58:44,080 --> 01:58:45,120
FOR THAT GRANT. THERE IS A LOT

2872
01:58:45,120 --> 01:58:48,120
OF OTHER INVESTIGATORS, ACTUALLY

2873
01:58:48,120 --> 01:58:49,800
MAJORITY WHO DO WANT TO BE

2874
01:58:49,800 --> 01:58:50,720
GUARANTEED EIGHT YEARS OF

2875
01:58:50,720 --> 01:58:52,720
CONTINUOUS FUNDING AT THE R 35

2876
01:58:52,720 --> 01:58:55,720
LEVEL. SO YES YOU ARE RIGHT, BUT

2877
01:58:55,720 --> 01:58:56,720
INVESTIGATOR GETS TO CHOOSE

2878
01:58:56,720 --> 01:58:58,040
WHETHER IT IS IN THEIR OWN

2879
01:58:58,040 --> 01:58:59,840
INTEREST. MAYBE LAST QUESTION

2880
01:58:59,840 --> 01:59:03,160
FROM GINA.

2881
01:59:03,160 --> 01:59:05,360
>> I -- WHEN WE CONSIDER
ABOUT

2882
01:59:05,360 --> 01:59:07,680
WHETHER TO PUT THIS EXTRA MONEY

2883
01:59:07,680 --> 01:59:10,840
INTO TRAINING OR FUNDING LINES,

2884
01:59:10,840 --> 01:59:13,040
I THINK IT WOULD BE GOOD TO

2885
01:59:13,040 --> 01:59:14,600
ADDRESS ALL THE RESEARCH THAT IS

2886
01:59:14,600 --> 01:59:17,080
ALREADY BEEN DONE IN TERMS OF

2887
01:59:17,080 --> 01:59:19,600
WHAT IS REALLY PREVENTING

2888
01:59:19,600 --> 01:59:21,160
SCIENCE FROM BEING MORE DIVERSE

2889
01:59:21,160 --> 01:59:23,360
THAN IT IS RIGHT NOW. IT IS NOT

2890
01:59:23,360 --> 01:59:25,800
JUST WHAT WE GUESS WHICH IS OH

2891
01:59:25,800 --> 01:59:29,280
WE NEED TO TRAIN MORE PEOPLE IT

2892
01:59:29,280 --> 01:59:31,520
IS NOT THAT, THOUGH TRAINING IS

2893
01:59:31,520 --> 01:59:32,800
GREAT, IT IS BEYOND TRAINING

2894
01:59:32,800 --> 01:59:36,360
LEVEL GETTINGED WITH RO1 HAVING

2895
01:59:36,360 --> 01:59:38,720
AN INSTITUTION THAT ACCEPTS AND

2896
01:59:38,720 --> 01:59:40,920
WELCOMES YOU, THINK A LOT OF THE

2897
01:59:40,920 --> 01:59:43,680
EFFORTS THE NINDS IS ALREADY

2898
01:59:43,680 --> 01:59:47,000
DOING REALLY WELL ESPECIALLY

2899
01:59:47,000 --> 01:59:50,600
WELL EXEMPLARY FASHION, I THINK

2900
01:59:50,600 --> 01:59:52,960
THAT IS THE PLACE WHERE WE

2901
01:59:52,960 --> 01:59:54,560
SHOULD CONTINUE THOSE EFFORTS

2902
01:59:54,560 --> 01:59:56,880
BECAUSE IT IS WORKING.  OR WE

2903
01:59:56,880 --> 01:59:57,640
HOPE IT IS WORKING.

2904
01:59:57,640 --> 02:00:02,400
>> I WOULD BE HAPPY TO
HAND

2905
02:00:02,400 --> 02:00:05,960
THESE OVER TO MY SHE WOULD JONES

2906
02:00:05,960 --> 02:00:09,000
LONDON. SO OKAY, DO YOU WANT TO

2907
02:00:09,000 --> 02:00:10,800
SAY ANY LESS COMMENTS WALTER? WE

2908
02:00:10,800 --> 02:00:12,440
DONE NEED TO VOTE ON THIS BUT I

2909
02:00:12,440 --> 02:00:14,080
WANTED TO TELL YOU WHAT'S GOING

2910
02:00:14,080 --> 02:00:16,880
ON AND FIND OUT IF THERE ARE ANY

2911
02:00:16,880 --> 02:00:20,520
INJECTIONS. -- OBJECTIONS.  

2912
02:00:20,520 --> 02:00:22,240
OKAY. I GUESS THE ANSWER IS NO

2913
02:00:22,240 --> 02:00:29,680
FOR WALTER. OKAY. WHY DON'T WE

2914
02:00:29,680 --> 02:00:32,200
TAKE A BREAK UNTIL 3:15 THEN YOU

2915
02:00:32,200 --> 02:00:33,680
WILL HEAR ABOUT THE HEAL

2916
02:00:33,680 --> 02:00:35,080
INITIATIVE. DISCUSSION AT THE

2917
02:00:35,080 --> 02:00:39,240
END OF THE DAY BY THE WAY WHICH

2918
02:00:39,240 --> 02:00:41,080
STARTS AT 4:45 IS GOING TO BE

2919
02:00:41,080 --> 02:00:43,880
ABOUT OPEN ACCESS PUBLISHING, WE

2920
02:00:43,880 --> 02:00:45,560
WILL GIVE YOU HEADS UP LATER.

2921
02:00:45,560 --> 02:00:47,600
WOULDN'T BE SURPRISED IF THAT

2922
02:00:47,600 --> 02:00:48,520
DISCUSSION GOES OVER SOMEWHAT.

2923
02:00:48,520 --> 02:00:49,600
WHEN I WAS A KID IN NEW YORK

2924
02:00:49,600 --> 02:00:52,040
CITY THE NEW SHOW WOULD SAY WE

2925
02:00:52,040 --> 02:00:54,440
ARE FORMING NETWORK AFFILIATES

2926
02:00:54,440 --> 02:00:57,320
THAT WE MAY GO OVER SO I'M

2927
02:00:57,320 --> 02:01:00,200
INFORMING AFFILIATES THAT

2928
02:01:00,200 --> 02:01:01,320
DISCUSSION COULD GO OVER AND I

2929
02:01:01,320 --> 02:01:03,080
THINK IT WILL BE AN INTERESTING

2930
02:01:03,080 --> 02:01:06,000
ONE. SEE YOU 3:15. 

2931
02:01:06,000 --> 02:01:13,080
OKAY.  SO THE NEXT ONCE A YEAR

2932
02:01:13,080 --> 02:01:15,040
WE GIVE AN UPDATE OF

2933
02:01:15,040 --> 02:01:17,600
APPROXIMATELY ONCE A YEAR ABOUT

2934
02:01:17,600 --> 02:01:18,080
HEAL BRAIN AND ALZHEIMER'S AND

2935
02:01:18,080 --> 02:01:20,720
THIS TIME WE ARE UP TO HEAL SO

2936
02:01:20,720 --> 02:01:24,440
WILL LET LINDA PORTER AND

2937
02:01:24,440 --> 02:01:25,280
MICHAEL OSHINSKY INTRODUCE

2938
02:01:25,280 --> 02:01:26,320
THEMSELVES.  LINDA, ARE YOU

2939
02:01:26,320 --> 02:01:27,360
FIRST?

2940
02:01:27,360 --> 02:01:31,320
>> I AM. YES. THANK YOU.
I'M

2941
02:01:31,320 --> 02:01:35,800
LINDA PORTER, DIRECTOR OF OFFICE

2942
02:01:35,800 --> 02:01:37,080
OF PLANNING AND POLICY, AND ONE

2943
02:01:37,080 --> 02:01:38,320
OF THE CO-CHAIRS FOR THE HEAL

2944
02:01:38,320 --> 02:01:39,840
INITIATIVE.LY START THIS

2945
02:01:39,840 --> 02:01:42,840
AFTERNOON. AND THEN MICHAEL WILL

2946
02:01:42,840 --> 02:01:44,400
PICK UP. SO I WILL COVER THE

2947
02:01:44,400 --> 02:01:45,280
CLINICAL PAIN RESEARCH

2948
02:01:45,280 --> 02:01:47,120
COMPONENTS OF HEAL AND THEN

2949
02:01:47,120 --> 02:01:48,680
MICHAEL WILL GIVE YOU AN UPDATE

2950
02:01:48,680 --> 02:01:51,640
ON THE TRANSLATIONAL AND

2951
02:01:51,640 --> 02:01:52,160
PRE-CLINICAL COMPONENTS. 

2952
02:01:52,160 --> 02:01:53,440
THERE'S A LOT IN BOTH PACKAGES

2953
02:01:53,440 --> 02:01:56,800
SO WE WILL MOVE QUICKLY.  SHARE

2954
02:01:56,800 --> 02:02:07,360
MY SCREEN NOW.  AND ONE SECOND. 

2955
02:02:11,000 --> 02:02:13,880
HOPEFULLY THAT LOOKS LIKE A

2956
02:02:13,880 --> 02:02:17,240
SLIDE SHOW.

2957
02:02:17,240 --> 02:02:19,600
>> YES, IT DOES.

2958
02:02:19,600 --> 02:02:21,400
>> READY TO GO. IT IS NOT

2959
02:02:21,400 --> 02:02:25,160
ADVANCING.  SO JUST TO GIVE A

2960
02:02:25,160 --> 02:02:28,120
LITTLE BACKGROUND ABOUT THE

2961
02:02:28,120 --> 02:02:29,600
PUBLIC HEALTH CRISIS OF CHRONIC

2962
02:02:29,600 --> 02:02:32,560
PAIN IN THE U.S. WE KNOW THAT WE

2963
02:02:32,560 --> 02:02:33,360
HAVE 50 MILLION ADULTS WHO

2964
02:02:33,360 --> 02:02:35,360
REPORT HAVING CHRONIC PAIN OVER

2965
02:02:35,360 --> 02:02:39,800
THE PAST THREE MONTHS, 25

2966
02:02:39,800 --> 02:02:43,920
MILLION WHOM SEVERE PAIN AND 20

2967
02:02:43,920 --> 02:02:45,680
MILLION WITH HIGH IMPACT CHRONIC

2968
02:02:45,680 --> 02:02:48,640
PAIN DEFINED AS MAYBE WITH THREE

2969
02:02:48,640 --> 02:02:49,560
OR FOUR MONTHS THAT INTERFERES

2970
02:02:49,560 --> 02:02:50,880
WITH LIFESTYLE SO CAN KEEP

2971
02:02:50,880 --> 02:02:52,480
PEOPLE FROM GOING TO WORK OR

2972
02:02:52,480 --> 02:02:54,480
SCHOOL, AND ENJOYING THEIR

2973
02:02:54,480 --> 02:02:55,320
ACTIVITIES AND THEIR SOCIAL

2974
02:02:55,320 --> 02:02:58,720
LIVES.  RECENTLY BECAUSE A LOT

2975
02:02:58,720 --> 02:03:01,080
OF PAIN QUESTIONS ARE NOW IN THE

2976
02:03:01,080 --> 02:03:04,160
NATIONAL HEALTH SURVEY, WE ARE

2977
02:03:04,160 --> 02:03:06,320
ACTUALLY GETTING MORE AND MORE

2978
02:03:06,320 --> 02:03:09,400
DATA ON THE PUBLIC IMPACT OF

2979
02:03:09,400 --> 02:03:15,000
PAIN, WE KNOW MORE WOMEN THAN

2980
02:03:15,000 --> 02:03:16,440
MEN HAVE PAIN CHRONIC AND HIGH

2981
02:03:16,440 --> 02:03:18,840
IMPACT CHRONIC PAIN. WE KNOW

2982
02:03:18,840 --> 02:03:20,640
RURAL DWELLERS ARE MORE AFFECTED

2983
02:03:20,640 --> 02:03:23,200
BY BOTH CHRONIC AND HIGH IMPACT

2984
02:03:23,200 --> 02:03:27,280
CHRONIC PAIN THAN ARE -- MOSTLY

2985
02:03:27,280 --> 02:03:29,800
DUE TO ACCESS TO GOOD CARE. THEN

2986
02:03:29,800 --> 02:03:31,320
WE ALSO KNOW THAT PREVALENCE OF

2987
02:03:31,320 --> 02:03:34,080
BOTH CHRONIC AND HIGH IMPACT

2988
02:03:34,080 --> 02:03:37,280
CHRONIC PAIN INCREASES

2989
02:03:37,280 --> 02:03:38,400
SIGNIFICANTLY OVER THE LIFE SPAN

2990
02:03:38,400 --> 02:03:41,640
MOST OF THE DATA IS FROM 18

2991
02:03:41,640 --> 02:03:45,840
YEARS OLD AND ON. WE KNOW THAT A

2992
02:03:45,840 --> 02:03:47,160
NUMBER OF DIFFERENT OTHER

2993
02:03:47,160 --> 02:03:49,240
CHRONIC CONDITIONS ARE

2994
02:03:49,240 --> 02:03:50,440
ASSOCIATED WITH BOTH PAIN AND

2995
02:03:50,440 --> 02:03:52,120
HIGH IMPACT CHRONIC PAIN. THIS

2996
02:03:52,120 --> 02:03:54,520
IS JUST ONE EXAMPLE OF MANY

2997
02:03:54,520 --> 02:03:58,280
WHERE THEY ARE CORRELATED.

2998
02:03:58,280 --> 02:04:01,120
DEMENTIA AND CHRONIC PAIN THE

2999
02:04:01,120 --> 02:04:04,440
ASSOCIATION RESULTS IN POOR

3000
02:04:04,440 --> 02:04:06,760
HEALTHCARE. AND INCREASING

3001
02:04:06,760 --> 02:04:07,920
SIGNIFICANTLY INCREASING MANNER

3002
02:04:07,920 --> 02:04:10,000
WHETHER YOU HAVE ONE, THE OTHER

3003
02:04:10,000 --> 02:04:15,360
ESPECIALLY IF YOU HAVE BOTH. SO

3004
02:04:15,360 --> 02:04:20,080
HEAL IS EXPANDING AND I THINK

3005
02:04:20,080 --> 02:04:23,160
ENHANCED PROGRAM IS EVOLVING

3006
02:04:23,160 --> 02:04:24,720
STILL OVER ITS ALREADY SHORT

3007
02:04:24,720 --> 02:04:26,680
LIFE SPAN, IT IS ALREADY CREATED

3008
02:04:26,680 --> 02:04:29,160
A NUMBER OF DIFFERENT IMPORTANT

3009
02:04:29,160 --> 02:04:30,680
PROGRAMS. INVOLVING SOME REALLY

3010
02:04:30,680 --> 02:04:32,200
CREATIVE WAYS THAT FILLS

3011
02:04:32,200 --> 02:04:34,920
RESEARCH GAP GAPS. TO DATE THEY

3012
02:04:34,920 --> 02:04:36,640
SPENT $2 BILLION ON RESEARCH FOR

3013
02:04:36,640 --> 02:04:41,320
PAIN AND OUD COMPONENTS OF HEAL 

3014
02:04:41,320 --> 02:04:43,480
THAT MAKES UP 6 PROJECTS 26

3015
02:04:43,480 --> 02:04:45,600
LARGER PROGRAMS, SO WE WILL TALK

3016
02:04:45,600 --> 02:04:47,400
HANDFUL OF PROGRAMS TODAY. ALL

3017
02:04:47,400 --> 02:04:49,200
50 STATES ARE SOMEHOW INVOLVED.

3018
02:04:49,200 --> 02:04:52,280
THEY HAVE RELEASED 50, 30 WHICH

3019
02:04:52,280 --> 02:04:54,400
CAME OUT FISCAL YEAR 22, FUNDING

3020
02:04:54,400 --> 02:04:58,320
OPPORTUNITY ANNOUNCEMENTS FOR

3021
02:04:58,320 --> 02:05:01,000
HEAL INITIATIVE ACTIVITIES. IF

3022
02:05:01,000 --> 02:05:03,480
YOU LOOK AT THE SPENDING ON THE

3023
02:05:03,480 --> 02:05:07,040
PAIN SIDE TO DATE I MICHAEL WILL

3024
02:05:07,040 --> 02:05:07,960
TALK 335 MILL WORTH OF

3025
02:05:07,960 --> 02:05:08,800
PRE-CLINICAL AND TRANSLATIONAL

3026
02:05:08,800 --> 02:05:12,400
RESEARCH, WE WILL TALK ABOUT

3027
02:05:12,400 --> 02:05:13,520
$350 MILLION IN CLINICAL

3028
02:05:13,520 --> 02:05:14,520
RESEARCH WHICH IS SPENDING TO

3029
02:05:14,520 --> 02:05:18,040
DATE.  MAIN THEMES ON THAT WE

3030
02:05:18,040 --> 02:05:19,440
WILL BE LOOKING AT TODAY ARE

3031
02:05:19,440 --> 02:05:21,160
THOSE THAT ARE RELATED TO THIS

3032
02:05:21,160 --> 02:05:24,320
IS A FAIRLY NEW ONE, INTEGRATED

3033
02:05:24,320 --> 02:05:26,200
THERAPIES FOR PEOPLE WHO HAVE

3034
02:05:26,200 --> 02:05:27,680
CO-OCCURRING PAIN AND ADDICTION

3035
02:05:27,680 --> 02:05:31,440
WHICH IS MANY OF THE PEOPLE WHO

3036
02:05:31,440 --> 02:05:33,240
HAVE OUD SUFFER FROM CHRONIC

3037
02:05:33,240 --> 02:05:35,960
PAIN, MICHAEL WILL TALK ABOUT

3038
02:05:35,960 --> 02:05:37,920
NEW THERAPEUTICS AND

3039
02:05:37,920 --> 02:05:39,160
UNDERSTANDING PAIN BETTER IN

3040
02:05:39,160 --> 02:05:40,760
CERTAIN PAIN CONDITIONS SO HELP

3041
02:05:40,760 --> 02:05:42,680
TARGET NEW THERAPIES AND I WILL

3042
02:05:42,680 --> 02:05:45,560
TALK ABOUT WHY THE PAIN

3043
02:05:45,560 --> 02:05:50,960
MANAGEMENT PROGRAMS. SO WE LOOK

3044
02:05:50,960 --> 02:05:54,880
AT THE PROGRAM OVERALL I THINK

3045
02:05:54,880 --> 02:05:57,240
YOU HAVE SEEN THIS CHEVRON CHART

3046
02:05:57,240 --> 02:06:01,600
IN A MUCH SMALLER OFFERING A

3047
02:06:01,600 --> 02:06:02,720
COUPLE OF YEARS AGO AND AGAIN

3048
02:06:02,720 --> 02:06:04,760
LAST YEAR, AS THE PROGRAM

3049
02:06:04,760 --> 02:06:06,160
EVOLVES WE ARE ADDING MORE

3050
02:06:06,160 --> 02:06:08,560
COMPONENTS TO IT. AND WE WILL

3051
02:06:08,560 --> 02:06:09,480
TALK ABOUT THESE PROGRAMS, NOT

3052
02:06:09,480 --> 02:06:10,960
GOING TO RUN THROUGH THE LIST

3053
02:06:10,960 --> 02:06:13,720
NOW BUT THE IDEA IS TO SHOW YOU

3054
02:06:13,720 --> 02:06:16,880
RESEARCH RUNS ALL THE WAY FROM

3055
02:06:16,880 --> 02:06:20,160
DISCOVERY THROUGH TO

3056
02:06:20,160 --> 02:06:21,200
IMPLEMENTATION/DISSEMINATION

3057
02:06:21,200 --> 02:06:23,560
RESEARCH. SO IT DOES COVER THE

3058
02:06:23,560 --> 02:06:26,080
CONTINUUM OF DIFFERENT TYPES OF

3059
02:06:26,080 --> 02:06:27,200
RESEARCH, WORKING TOWARDS

3060
02:06:27,200 --> 02:06:28,720
GETTING NEW THERAPIES INTO THE

3061
02:06:28,720 --> 02:06:32,240
CLINIC. HEAL IS ALSO BEGINNING

3062
02:06:32,240 --> 02:06:34,960
TO EMBED, GOT REALLY GOOD START

3063
02:06:34,960 --> 02:06:36,640
NUMBER OF CROSS CUTTING ISSUES

3064
02:06:36,640 --> 02:06:38,720
INTO THEIR PROGRAMS THROUGH

3065
02:06:38,720 --> 02:06:40,360
SUPPLEMENTS OR SEPARATE FOAs

3066
02:06:40,360 --> 02:06:41,640
AND THOSE INCLUDE THINGS LIKE

3067
02:06:41,640 --> 02:06:43,880
REALLY ENHANCING PATIENT

3068
02:06:43,880 --> 02:06:46,280
ENGAGEMENT IN ALL STAGES OF THE

3069
02:06:46,280 --> 02:06:47,720
RESEARCH ENDEAVOR IN AN

3070
02:06:47,720 --> 02:06:50,600
INDIVIDUAL FOA AND INDIVIDUAL

3071
02:06:50,600 --> 02:06:52,520
TRIALS. INDIVIDUAL PROJECTS.

3072
02:06:52,520 --> 02:06:56,440
WORKING REALLY HARD TO ENHANCE

3073
02:06:56,440 --> 02:06:59,520
THE WORK FORCE FOR THE CLINICAL

3074
02:06:59,520 --> 02:07:03,040
AND PRE-CLINICAL PAIN RESEARCH

3075
02:07:03,040 --> 02:07:04,800
THAT INCLUDES THE SIZE OF WORK

3076
02:07:04,800 --> 02:07:06,960
FORCE, THE QUALITY OF WORK FORCE

3077
02:07:06,960 --> 02:07:08,360
AN DIVERSITY OF THE WORK FORCE.

3078
02:07:08,360 --> 02:07:09,720
MICHAEL AND I WILL EACH TALK

3079
02:07:09,720 --> 02:07:11,440
ABOUT THE PROGRAMS THAT FALL

3080
02:07:11,440 --> 02:07:14,640
UNDER THAT CATEGORY. DATA

3081
02:07:14,640 --> 02:07:17,000
HARMONIZATION HAS BEEN A HUGE

3082
02:07:17,000 --> 02:07:19,360
PART OF THE EFFORT FOR THE

3083
02:07:19,360 --> 02:07:21,760
CLINICAL RESEARCH TEAM AND THERE

3084
02:07:21,760 --> 02:07:24,840
IS A DATA PROGRAM THAT IS BEING

3085
02:07:24,840 --> 02:07:27,400
LAUNCHED THROUGH HEAL WHICH YOU

3086
02:07:27,400 --> 02:07:29,440
HAVE HEARD ABOUT HERE AND THERE

3087
02:07:29,440 --> 02:07:30,480
EARLIER. WE HAVE SOME PROGRAMS

3088
02:07:30,480 --> 02:07:32,160
NOW OR A PROGRAM NOW TO LOOK AT

3089
02:07:32,160 --> 02:07:35,520
SECONDARY DATA ANALYSIS AS DATA

3090
02:07:35,520 --> 02:07:37,240
BEGINS TO FLOW FROM THE HEAL

3091
02:07:37,240 --> 02:07:38,920
STUDIES BUT IT WOULD ALSO BE

3092
02:07:38,920 --> 02:07:41,600
ABLE TO LOOK AT OTHER STUDIES

3093
02:07:41,600 --> 02:07:43,240
THAT HAVE BEEN PUBLISHED AND

3094
02:07:43,240 --> 02:07:45,200
PRODUCED SIGNIFICANT DATA OTHER

3095
02:07:45,200 --> 02:07:50,440
THAN HEAL STUDIES.  I HAVE TO

3096
02:07:50,440 --> 02:07:55,120
HIT THE DOWN BUTTON THREE TIMES

3097
02:07:55,120 --> 02:07:59,600
BECAUSE IT IS STILL NOT WORKING 

3098
02:07:59,600 --> 02:08:01,120
TIM DUE HAPPEN TO HAVE MY SLIDE

3099
02:08:01,120 --> 02:08:04,160
-- THERE WE GO. SO THE CLINICAL

3100
02:08:04,160 --> 02:08:05,840
RESEARCH AND PAIN MANAGEMENT

3101
02:08:05,840 --> 02:08:09,440
PROGRAM COVERS RESEARCH NETWORKS

3102
02:08:09,440 --> 02:08:12,320
THAT CAN BRING THERAPEUTICS

3103
02:08:12,320 --> 02:08:14,040
WHETHER THEY BE PHARMACOLOGICAL

3104
02:08:14,040 --> 02:08:16,280
OR NON-PHARMACOLOGICAL THROUGH

3105
02:08:16,280 --> 02:08:19,920
ALMOST ALL STAGES OF CLINICAL

3106
02:08:19,920 --> 02:08:22,880
TRIAL INVESTIGATION. WE HAVE A

3107
02:08:22,880 --> 02:08:24,080
PHASE 2 EPIC NET INVESTIGATION

3108
02:08:24,080 --> 02:08:27,240
NETWORK. WE HAVE THE BACK PAIN

3109
02:08:27,240 --> 02:08:28,920
CONSORTIUM, CALLED BACKPACK

3110
02:08:28,920 --> 02:08:31,160
WHICH INCLUDES NOT ONLY EARLY

3111
02:08:31,160 --> 02:08:35,560
PHASE TRIALS BUT BRINGS THEM ALL

3112
02:08:35,560 --> 02:08:36,720
UP THROUGH STAGE 3 CLINICAL

3113
02:08:36,720 --> 02:08:38,840
TRIALS LARGE EFFECTIVENESS

3114
02:08:38,840 --> 02:08:40,680
TRIALS, RUNNING A LARGE

3115
02:08:40,680 --> 02:08:42,760
HEMODIALYSIS TRIAL FOR PAIN

3116
02:08:42,760 --> 02:08:45,320
ASSOCIATED HEMODIALYSIS WITH

3117
02:08:45,320 --> 02:08:46,520
PEOPLE WITH LATE STAGE KIDNEY

3118
02:08:46,520 --> 02:08:48,280
DISEASE, THAT STUDY IS ONE BIG

3119
02:08:48,280 --> 02:08:49,360
STUDY AT MULTIPLE SITES ACROSS

3120
02:08:49,360 --> 02:08:53,720
THE COUNTRY. IS UP AND RUNNING

3121
02:08:53,720 --> 02:08:54,920
AND I THINK ABOUT HALFWAY

3122
02:08:54,920 --> 02:08:56,280
THROUGH RECRUITMENT SO HOPEFULLY

3123
02:08:56,280 --> 02:08:57,960
THE NEXT FEW YEARS WE WILL HAVE

3124
02:08:57,960 --> 02:09:00,080
GOOD DATA ON THAT. THE

3125
02:09:00,080 --> 02:09:01,400
EFFECTIVENESS RESEARCH NETWORK

3126
02:09:01,400 --> 02:09:05,720
IS RUNNING A NUMBER OF DIFFERENT

3127
02:09:05,720 --> 02:09:07,320
STAGE 3 CLINICAL TRIALS, WE HAVE

3128
02:09:07,320 --> 02:09:10,320
PRAGMATIC STUDIES GOING ON

3129
02:09:10,320 --> 02:09:12,240
THROUGH ANOTHER PROGR PROGRAM. E

3130
02:09:12,240 --> 02:09:13,760
ARE HYBRID EFFECTIVEN 'T

3131
02:09:13,760 --> 02:09:16,200
IMPLEMENTATION STUDIES TO BRING

3132
02:09:16,200 --> 02:09:20,080
EVIDENCE BASED TREATMENT INTO

3133
02:09:20,080 --> 02:09:22,800
HEALTHCARE SYSTEMS M. WE HAVE A

3134
02:09:22,800 --> 02:09:24,000
NEW PROGRAM LAUNCHED LAST YEAR

3135
02:09:24,000 --> 02:09:27,040
INTEGRATED MANAGEMENT CHRONIC

3136
02:09:27,040 --> 02:09:28,240
PAIN AND OCTOBERUD.  THESE ARE

3137
02:09:28,240 --> 02:09:30,680
SPECIALIZED -- OUD.  THESE COVER

3138
02:09:30,680 --> 02:09:32,280
TREATMENT FOR PAIN AND OUD AT

3139
02:09:32,280 --> 02:09:36,880
THE SAME TIME. THEN WE HAVE ONE

3140
02:09:36,880 --> 02:09:38,600
NUMBER OF PROGRAMS TO ENHANCE

3141
02:09:38,600 --> 02:09:42,800
THE CLINICAL PAIN RESEARCH WORK

3142
02:09:42,800 --> 02:09:44,320
FORCE, THE BIOMARKER PROGRAM WE

3143
02:09:44,320 --> 02:09:45,720
TOLD YOU ABOUT EARLIER IS WELL

3144
02:09:45,720 --> 02:09:49,800
UNDERWAY. WE REALIGNED THE

3145
02:09:49,800 --> 02:09:51,800
BIOMARKER PROGRAM. TO FOCUS ON

3146
02:09:51,800 --> 02:09:52,640
BIOMARKERS FOR CLINICAL TRIALS

3147
02:09:52,640 --> 02:09:57,240
AND ALSO A NEW PROGRAM ON

3148
02:09:57,240 --> 02:09:59,160
BIOMARKERS FOR MY TISSUES AND A

3149
02:09:59,160 --> 02:10:00,760
NEW PROGRAM ABOUT TO LAUNCH

3150
02:10:00,760 --> 02:10:04,160
ADVANCING HEALTH EQUITY IN PAIN

3151
02:10:04,160 --> 02:10:07,480
CARE MANAGEMENT. STARTING AT THE

3152
02:10:07,480 --> 02:10:09,040
BEGINNING AS FAR AS THE EARLY

3153
02:10:09,040 --> 02:10:10,840
PART OF THE CLINICAL TRIAL

3154
02:10:10,840 --> 02:10:13,320
NETWORK, THE EARLY PHASE

3155
02:10:13,320 --> 02:10:18,120
PRE-CLINICAL NETWORK IS THE EPIC

3156
02:10:18,120 --> 02:10:20,200
NET AND IT IS IN PLANNING STAGES

3157
02:10:20,200 --> 02:10:23,040
FOR TWO NEW TRIALS ON DIABETIC

3158
02:10:23,040 --> 02:10:24,520
NEUROPATHY BUT HAS FINISHED OUT

3159
02:10:24,520 --> 02:10:26,640
MOST OF THE PLANNING AND IS

3160
02:10:26,640 --> 02:10:29,960
READY TO LAUNCH A STUDY FOR

3161
02:10:29,960 --> 02:10:30,720
NEOOSTEOARTHRITIS, THEY ARE

3162
02:10:30,720 --> 02:10:32,880
ABOUT TO RECRUIT, THEY HAVE BEEN

3163
02:10:32,880 --> 02:10:34,120
DOING FAIR BIT OF SCREENING TO

3164
02:10:34,120 --> 02:10:37,560
GET TO THAT LEVEL. THIS WILL

3165
02:10:37,560 --> 02:10:40,280
LOOK AT EFFECT OF THE EFFICACY

3166
02:10:40,280 --> 02:10:44,600
OF CCR 2 ANTAGONIST BEFORE

3167
02:10:44,600 --> 02:10:47,720
ADULTS WITH OSTEOARTHRITIS KNEE

3168
02:10:47,720 --> 02:10:50,880
PAIN. THIS IS A REALLY IMPORTANT

3169
02:10:50,880 --> 02:10:52,320
STUDY GIVEN HOW MANY PEOPLE

3170
02:10:52,320 --> 02:10:54,480
ESPECIALLY THOSE OVER AGE 40,

3171
02:10:54,480 --> 02:10:56,160
HAVE KNEE PAIN DUE TO

3172
02:10:56,160 --> 02:10:58,640
OSTEOARTHRITIS. THE DIABETIC

3173
02:10:58,640 --> 02:11:00,160
NEUROPATHY TRIALS WILL BE RUN

3174
02:11:00,160 --> 02:11:02,840
UNDER A MASTER PROTOCOL SO DONE

3175
02:11:02,840 --> 02:11:06,280
IN A SIMILAR WAY WITH SOME

3176
02:11:06,280 --> 02:11:09,280
TAILORED COMPONENTS IN THEM THAT

3177
02:11:09,280 --> 02:11:14,800
ARE UNIQUE TO ASSET THAT IS

3178
02:11:14,800 --> 02:11:17,480
UNDERSTUDY, ONE IS TOPICAL AND

3179
02:11:17,480 --> 02:11:19,240
ONE IS AN ORAL INDICATION.  SO

3180
02:11:19,240 --> 02:11:21,200
THESE ARE STILL IN THE PLANNING

3181
02:11:21,200 --> 02:11:22,840
PHASE BUT WE HOPE LATER THIS

3182
02:11:22,840 --> 02:11:28,600
YEAR THAT THEY WILL ALSO LAUNCH.

3183
02:11:28,600 --> 02:11:30,880
BACPAC IS A COMPLEX PROGRAM, AN

3184
02:11:30,880 --> 02:11:34,520
INITIATIVE IN ITSELF. SO IT HAS

3185
02:11:34,520 --> 02:11:37,560
SEVERAL COMPONENTS WHICH

3186
02:11:37,560 --> 02:11:38,840
INCLUDES MECHANISTIC CENTER

3187
02:11:38,840 --> 02:11:40,920
WHERE TRYING TO BETTER

3188
02:11:40,920 --> 02:11:42,680
UNDERSTAND THE ETIOLOGY OF LOW

3189
02:11:42,680 --> 02:11:44,680
BACK PAIN AND THE DIFFERENT

3190
02:11:44,680 --> 02:11:47,800
COMPONENTS THAT CONTRIBUTE TO

3191
02:11:47,800 --> 02:11:49,960
IT. THEY GOT OTHER CENTERS THAT

3192
02:11:49,960 --> 02:11:52,960
ARE WORKING TO DEVELOP DEVICES

3193
02:11:52,960 --> 02:11:57,080
THAT CAN HELP WITH TREATMENT OR

3194
02:11:57,080 --> 02:11:59,720
DIAGNOSIS AND THEY ARE RUNNING

3195
02:11:59,720 --> 02:12:01,400
SOME CLINICAL TRIALS. THIS SLIDE

3196
02:12:01,400 --> 02:12:03,360
GIVES YOU A COUPLE OF EXAMPLES

3197
02:12:03,360 --> 02:12:06,600
OF SOME OF THE WORK COMING OUT

3198
02:12:06,600 --> 02:12:10,440
OF THE DEVICE ACTIVITY AND HOW

3199
02:12:10,440 --> 02:12:12,520
SOME OF THE DEVICES ARE BEING

3200
02:12:12,520 --> 02:12:16,920
APPLIED TO EITHER DIAGNOSTICS OR

3201
02:12:16,920 --> 02:12:19,400
TO BACK PAIN THERAPIES. ONE OF

3202
02:12:19,400 --> 02:12:23,600
THE BIG GOALS OVERALL GOALS FOR

3203
02:12:23,600 --> 02:12:26,120
BACK PACK WAS TO AND IS TO

3204
02:12:26,120 --> 02:12:28,760
DEVELOP A THEORETICAL MODEL FOR

3205
02:12:28,760 --> 02:12:29,520
LOW BACK MAYBE INCLUDE

3206
02:12:29,520 --> 02:12:33,040
MECHANISMS PHENOTYPING

3207
02:12:33,040 --> 02:12:34,240
BIOMECHANICS AND THAT MODEL

3208
02:12:34,240 --> 02:12:39,320
WOULD BE BROUGHT INTO BACKPACK

3209
02:12:39,320 --> 02:12:40,920
STUDIES OVER TIME, IT WOULD BE

3210
02:12:40,920 --> 02:12:45,080
REFINED REDEFINED AS DATA FROM

3211
02:12:45,080 --> 02:12:46,440
BACPAC COMES IN. SO ONE THING I

3212
02:12:46,440 --> 02:12:48,920
WANT TO HIGHLIGHT AS AN

3213
02:12:48,920 --> 02:12:50,560
ACCOMPLISHMENT FOR BACPAC IS

3214
02:12:50,560 --> 02:12:53,240
THAT THE THEORETICAL MODEL FOR

3215
02:12:53,240 --> 02:12:54,760
LOW BACK PAIN DURING THE FIRST

3216
02:12:54,760 --> 02:12:57,720
FEW YEARS OF PLANNING IN THE

3217
02:12:57,720 --> 02:12:59,120
BACPAC PROGRAM HAS BEEN

3218
02:12:59,120 --> 02:13:01,240
DEVELOPED AND IT IS NOW IT WILL

3219
02:13:01,240 --> 02:13:03,760
GO AS USEFUL TOOL INTO THE

3220
02:13:03,760 --> 02:13:05,360
CLINICAL TRIALS AND BE REFINED

3221
02:13:05,360 --> 02:13:11,480
AS THEY MOVE FORWARD. THERE IS

3222
02:13:11,480 --> 02:13:14,280
ALSO FDA BREAK THROUGH APPROVAL

3223
02:13:14,280 --> 02:13:17,400
FOR DEVICE DESIGNATION FOR A

3224
02:13:17,400 --> 02:13:18,840
PLATFORM THAT WAS DEVELOPED

3225
02:13:18,840 --> 02:13:21,480
THROUGH ONE OF THE DEVICE

3226
02:13:21,480 --> 02:13:23,160
TECHNOLOGY PROGRAMS IN BACPAC. 

3227
02:13:23,160 --> 02:13:26,160
THIS IS A DIGITAL HEALTH

3228
02:13:26,160 --> 02:13:30,960
PLATFORM THAT PULSING TO

3229
02:13:30,960 --> 02:13:32,520
INFORMATION ON BIOMECHANICS

3230
02:13:32,520 --> 02:13:33,520
SPINE SIGNATURES PATIENT

3231
02:13:33,520 --> 02:13:36,120
REPORTED OUTCOMES AND ELECTRONIC

3232
02:13:36,120 --> 02:13:37,800
HEALTH RECORD DATA, PULSE THOSE

3233
02:13:37,800 --> 02:13:39,400
ALL TOGETHER AS TO HOW THEY CAN

3234
02:13:39,400 --> 02:13:42,040
BE USED IN RESEARCH OR IN THE

3235
02:13:42,040 --> 02:13:46,240
CLINIC, SO THIS IS GOING TO BE

3236
02:13:46,240 --> 02:13:48,360
HUGE HELP FOR RESEARCH PROGRAMS

3237
02:13:48,360 --> 02:13:51,880
AND BACPAC MOVES FORWARD.  THEN

3238
02:13:51,880 --> 02:13:54,560
WE MOVE INTO THE PAIN MANAGEMENT

3239
02:13:54,560 --> 02:13:57,080
EFFECTIVENESS RESEARCH NETWORK,

3240
02:13:57,080 --> 02:13:58,680
WE CURRENTLY HAVE 8 TRIALS

3241
02:13:58,680 --> 02:14:02,720
UNDERWAY.  THEY ARE ALL PAST

3242
02:14:02,720 --> 02:14:06,280
THEIR PLANNING YEAR AND ALL ITS

3243
02:14:06,280 --> 02:14:07,600
RECRUITSMENT, SOME PHENOMENALLY

3244
02:14:07,600 --> 02:14:09,760
WELL RECRUITING DESPITE SLOW

3245
02:14:09,760 --> 02:14:11,120
DOWNS FROM COVID, THEY HAVE HAD

3246
02:14:11,120 --> 02:14:12,920
TO MAKE BECAUSE OF COVID A

3247
02:14:12,920 --> 02:14:14,800
NUMBER OF CHANGES AND SOME OF

3248
02:14:14,800 --> 02:14:18,320
THE PROGRAMS MOVING THEM TO

3249
02:14:18,320 --> 02:14:19,160
TELEHEALTH OR OTHER DIFFERENT

3250
02:14:19,160 --> 02:14:21,120
TYPES OF VIRTUAL INTERACTIONS

3251
02:14:21,120 --> 02:14:22,560
AND SO I THINK SOME THOSE WILL

3252
02:14:22,560 --> 02:14:24,720
BE HELPFUL IN DETERMINING

3253
02:14:24,720 --> 02:14:29,960
WHETHER INTERVENTIONS THAT ARE

3254
02:14:29,960 --> 02:14:31,560
USEFUL IN FACE TO FACE SITUATION

3255
02:14:31,560 --> 02:14:34,120
IS ALSO USEFUL IN AREAS SUCH AS

3256
02:14:34,120 --> 02:14:36,520
RURAL SETTINGS, IN AREAS POST

3257
02:14:36,520 --> 02:14:38,880
COVID WHERE TELEHEALTH COULD BE

3258
02:14:38,880 --> 02:14:40,120
DELIVERED IN MORE EFFECTIVE

3259
02:14:40,120 --> 02:14:42,600
WAYS. THIS SLIDE GIVES YOU THE

3260
02:14:42,600 --> 02:14:43,640
IDEA THAT THIS DIFFERENT

3261
02:14:43,640 --> 02:14:44,640
INTERVENTIONS THAT ARE BEING

3262
02:14:44,640 --> 02:14:55,000
TESTED, THROUGH THE

3263
02:14:55,360 --> 02:14:59,400
>> ETHICAL
NON-PHARMACOLOGICAL

3264
02:14:59,400 --> 02:15:00,560
FILES GOING ON AND STRAIGHT UP

3265
02:15:00,560 --> 02:15:01,040
DRUG OR STRAIGHT UP

3266
02:15:01,040 --> 02:15:02,440
NON-PHARMACOLOGICAL

3267
02:15:02,440 --> 02:15:03,640
INTERVENTIONS IN ALL OF THE

3268
02:15:03,640 --> 02:15:04,520
DIFFERENT PAIN CONDITIONS THAT

3269
02:15:04,520 --> 02:15:05,360
YOU SEE ON THE RIGHT SIDE OF THE

3270
02:15:05,360 --> 02:15:07,840
TRIAL. ONE THING TO NOTE FROM

3271
02:15:07,840 --> 02:15:08,720
HERE, THESE ARE ALL -- WE WON'T

3272
02:15:08,720 --> 02:15:10,560
HAVE DATA,COMPLETED DATA ON THE

3273
02:15:10,560 --> 02:15:12,240
TRIALS FOR ANOTHER FEW YEARS BUT

3274
02:15:12,240 --> 02:15:15,680
ONE OF THE TRIALS WHICH WAS

3275
02:15:15,680 --> 02:15:17,440
LOOKING AT PRESCRIPTION OF

3276
02:15:17,440 --> 02:15:19,200
OPIOIDS, AND DECISION MAKINGS

3277
02:15:19,200 --> 02:15:21,960
WITH PATIENTS ON THE OPIOID,

3278
02:15:21,960 --> 02:15:24,880
GIVING THEM A STANDARD 20 DOSES

3279
02:15:24,880 --> 02:15:28,160
THAT MOST CAESAREAN PATIENTS GET

3280
02:15:28,160 --> 02:15:29,600
WHEN THEY GO HOME OR WHETHER

3281
02:15:29,600 --> 02:15:31,320
THEY GET A TAILORED DOSE

3282
02:15:31,320 --> 02:15:32,520
DEPENDING ON EDUCATION BETWEEN

3283
02:15:32,520 --> 02:15:34,520
THE PATIENT AND THE PROVIDER, AS

3284
02:15:34,520 --> 02:15:35,920
TO WHAT THE NEEDS ARE AND THE

3285
02:15:35,920 --> 02:15:37,400
DECISIONS OF THE PATIENT.  THEY

3286
02:15:37,400 --> 02:15:40,600
ARE FULLY ENROLLED AND HAVE BEEN

3287
02:15:40,600 --> 02:15:42,880
FOR FEW MONTHS NOW DESPITE COVID

3288
02:15:42,880 --> 02:15:43,920
5,000 PLUS PARTICIPANTS SO WE

3289
02:15:43,920 --> 02:15:45,800
LOOK FORWARD TO SOME INFORMATION

3290
02:15:45,800 --> 02:15:47,680
FROM THAT TRIAL. IN THE NOT SO

3291
02:15:47,680 --> 02:15:51,440
DISTANT FUTURE. WE CAN MOVE INTO

3292
02:15:51,440 --> 02:15:54,600
THE PRAGMATIC TRIALS, THESE ARE

3293
02:15:54,600 --> 02:15:56,000
THE IMPLEMENTATION TRIALS, DONE

3294
02:15:56,000 --> 02:15:56,920
IN HEALTHCARE SYSTEMS, THEY HAVE

3295
02:15:56,920 --> 02:15:59,720
TO BE DONE IN AT LEAST TWO. THEY

3296
02:15:59,720 --> 02:16:03,240
ARE LOOKING ALL AT

3297
02:16:03,240 --> 02:16:04,240
NON-PHARMACOLOGICAL APPROACH TO

3298
02:16:04,240 --> 02:16:07,160
PAIN MANAGEMENT. SO ON THE LEFT

3299
02:16:07,160 --> 02:16:09,320
YOU SEE DIFFERENCE TYPES

3300
02:16:09,320 --> 02:16:11,320
COMBINATIONS OF THERAPIES THAT

3301
02:16:11,320 --> 02:16:13,720
ARE BEING EVALUATED AND ON THE

3302
02:16:13,720 --> 02:16:19,880
RIGHT HAND SIDE YOU SEE PAIN

3303
02:16:19,880 --> 02:16:21,040
CONDITIONS BEING -- INCLUDED AS

3304
02:16:21,040 --> 02:16:22,400
PART OF THE COHORTS IN THESE

3305
02:16:22,400 --> 02:16:25,400
STUDIES.  WE HAVE SIX TRIALS

3306
02:16:25,400 --> 02:16:27,800
GOING ON THREE THOSE LOW BACK

3307
02:16:27,800 --> 02:16:30,800
PAIN SO NUMBERS ADD TO SIX. FOR

3308
02:16:30,800 --> 02:16:35,880
WHAT WE CALL PRISM FOR THIS

3309
02:16:35,880 --> 02:16:36,440
IMPLEMENTATION PROGRAM THEY

3310
02:16:36,440 --> 02:16:38,120
AGAIN WON'T HAVE CLINICAL

3311
02:16:38,120 --> 02:16:40,240
OUTCOMES DATA FOR SOME TIME.

3312
02:16:40,240 --> 02:16:43,760
THEY GOT TOGETHER WITH A

3313
02:16:43,760 --> 02:16:46,760
COLLABORATORY THAT WE HAD AT NIH

3314
02:16:46,760 --> 02:16:48,360
FOR SOME TIME WITH PRAGMATIC

3315
02:16:48,360 --> 02:16:51,720
TRIALS AND PUBLISHED A SURVEY ON

3316
02:16:51,720 --> 02:16:53,360
THE DIFFERENT CHALLENGES OF

3317
02:16:53,360 --> 02:16:55,000
USING ELECTRONIC HEALTHCARE

3318
02:16:55,000 --> 02:16:57,240
RECORD DATA IN LARGE TRIALS.

3319
02:16:57,240 --> 02:16:59,640
THESE STUDIES ARE VERY RELIANT

3320
02:16:59,640 --> 02:17:04,960
ON EHR DATA AND THEY WENT TO

3321
02:17:04,960 --> 02:17:06,200
REALLY CONSENSUS ON

3322
02:17:06,200 --> 02:17:07,280
PRE-REQUISITES HOW THAT DATA

3323
02:17:07,280 --> 02:17:09,280
SHOULD BE ENTERED IN MAKING SURE

3324
02:17:09,280 --> 02:17:12,960
ALL THE PROs ARE IN, DATA IS

3325
02:17:12,960 --> 02:17:15,680
COLLECTED, CONSISTENTLY AND

3326
02:17:15,680 --> 02:17:17,800
NUMBERS OF DATA POINTS TO TO BE

3327
02:17:17,800 --> 02:17:19,600
USED IN THESE TRIALS TO MAKE

3328
02:17:19,600 --> 02:17:23,600
THEM MORE EFFECTIVE. SO THIS IS

3329
02:17:23,600 --> 02:17:25,240
THE NEW PROGRAM THAT I MENTION

3330
02:17:25,240 --> 02:17:26,880
LOOKING AT INTEGRATIVE

3331
02:17:26,880 --> 02:17:29,360
MANAGEMENT FOR BOTH CHRONIC PAIN

3332
02:17:29,360 --> 02:17:33,080
AND OUD. IF YOU LOOK AT THE NEED

3333
02:17:33,080 --> 02:17:35,440
FOR THIS AT THE POPULATION LEVEL

3334
02:17:35,440 --> 02:17:38,000
IT IS HUGE. SO AS I MENTION WE

3335
02:17:38,000 --> 02:17:39,840
HAVE GOT 50 MILLION PEOPLE,

3336
02:17:39,840 --> 02:17:42,120
ADULT MS. THE U.S. EVERY YEAR

3337
02:17:42,120 --> 02:17:44,720
THAT REPORT CHRONIC PAIN OPIOID

3338
02:17:44,720 --> 02:17:47,840
MISUSE OF POPULATION LEVEL IS

3339
02:17:47,840 --> 02:17:49,320
ABOUT 10 MILLION PEOPLE. THOSE

3340
02:17:49,320 --> 02:17:52,760
WITH OUD WHICH IS ABOUT 2

3341
02:17:52,760 --> 02:17:56,680
MILLION PEOPLE, MOST OF THEM 40

3342
02:17:56,680 --> 02:17:59,280
TO 60% WHO HAVE OUD ALSO HAVE

3343
02:17:59,280 --> 02:18:01,200
CHRONIC PAIN. WHEN THEY GO FOR

3344
02:18:01,200 --> 02:18:02,800
TREATMENT IT IS EITHER ONE OR

3345
02:18:02,800 --> 02:18:05,000
THE OTHER TREATMENTS MAYBE CUT

3346
02:18:05,000 --> 02:18:07,760
OFF BY THEIR PROVIDER. OR IS

3347
02:18:07,760 --> 02:18:09,440
FRAGMENTED IN THAT THEY MAY END

3348
02:18:09,440 --> 02:18:12,240
UP IN WITH PAIN CARE AND JUST

3349
02:18:12,240 --> 02:18:14,720
REFERRAL FOR OUD OR VICE VERSA

3350
02:18:14,720 --> 02:18:16,080
OR MAYBE DROP BY THEIR PHYSICIAN

3351
02:18:16,080 --> 02:18:18,400
SO THE NEED FOR INTEGRATED CARE

3352
02:18:18,400 --> 02:18:21,760
IS REALLY HIGH. WE NEED TO KNOW

3353
02:18:21,760 --> 02:18:24,960
WHICH STRATEGIES ARE BEST FOR

3354
02:18:24,960 --> 02:18:27,480
WHICH PEOPLE ONE OF THE OTHER

3355
02:18:27,480 --> 02:18:29,560
PROBLEMS IS THERE ARE LIMITED

3356
02:18:29,560 --> 02:18:31,360
RESOURCES, SPECIALTY CLINICS, ET

3357
02:18:31,360 --> 02:18:33,200
CETERA WHO CAN PROVIDE

3358
02:18:33,200 --> 02:18:36,160
INTEGRATED CARE. SO IN POWER

3359
02:18:36,160 --> 02:18:38,440
WHICH IS INTEGRATED MANAGEMENT

3360
02:18:38,440 --> 02:18:40,040
OF PAIN OUD FOR FULL RECOVERY IN

3361
02:18:40,040 --> 02:18:46,480
A SINGLE PERSON, HAS DEVELOPED

3362
02:18:46,480 --> 02:18:49,920
THROUGH A NUMBER OF TRIALS.  WE

3363
02:18:49,920 --> 02:18:51,040
HAVE NINE TRIALS RUNNING THROUGH

3364
02:18:51,040 --> 02:18:54,840
THE NEW PROGRAMS, LOOKING AT

3365
02:18:54,840 --> 02:18:59,680
DIFFERENT APPROACH AT MULTIPLE

3366
02:18:59,680 --> 02:19:01,960
LEVELS, EITHER INDIVIDUAL

3367
02:19:01,960 --> 02:19:05,800
HEALTHCARE SYSTEM OR PROVIDER,

3368
02:19:05,800 --> 02:19:07,480
TO BETTER TREAT PEOPLE WHO HAVE

3369
02:19:07,480 --> 02:19:12,440
BOTH PAIN AND OUD. THIS INCLUDES

3370
02:19:12,440 --> 02:19:14,360
DEALING WITH STIGMA AND HEALTH

3371
02:19:14,360 --> 02:19:17,360
DISPARITIES MANY THE CLINIC. 

3372
02:19:17,360 --> 02:19:18,800
AGAIN, THIS PROGRAM IS BRAND

3373
02:19:18,800 --> 02:19:22,200
NEW, THEY ARE GETTING THROUGH

3374
02:19:22,200 --> 02:19:26,840
THERE. I'M STUCK AGAIN. THEY ARE

3375
02:19:26,840 --> 02:19:28,360
GETTING TRUE THEIR PLANNING YEAR

3376
02:19:28,360 --> 02:19:29,200
AND WHAT THEY HAVE DONE IN THE

3377
02:19:29,200 --> 02:19:30,640
PLANNING YEAR WHICH IS REQUIRED

3378
02:19:30,640 --> 02:19:35,000
MANY THE FOA IS TO SET UP

3379
02:19:35,000 --> 02:19:38,320
APPROPRIATE DOMAINS FOR INQUIRY

3380
02:19:38,320 --> 02:19:39,720
OF PATIENTS THROUGH PATIENT

3381
02:19:39,720 --> 02:19:42,400
REPORTED OUTCOMES, ON BOTH PAIN

3382
02:19:42,400 --> 02:19:46,320
AND OUD WHICH WILL GIVE US A

3383
02:19:46,320 --> 02:19:51,480
GOOD DATA SET TO BE ABLE TO

3384
02:19:51,480 --> 02:19:53,360
CAPTURE THE FEATURES OF PEOPLE

3385
02:19:53,360 --> 02:19:55,600
WHO HAVE PAIN AND OUD AND

3386
02:19:55,600 --> 02:19:59,960
APPROACH THEM WITH INTEGRATED

3387
02:19:59,960 --> 02:20:02,920
HEALTHCARE PLAN. THEN WE MOVE TO

3388
02:20:02,920 --> 02:20:06,640
THE BIOMARKER PROGRAMS. SO ON

3389
02:20:06,640 --> 02:20:08,320
CHEVRON SLIDE I MENTIONED WE

3390
02:20:08,320 --> 02:20:12,280
HAVE A NEW PROGRAM LOOKING AT

3391
02:20:12,280 --> 02:20:16,240
BIOMARKERS OF MYOFACIAL TISSUES.

3392
02:20:16,240 --> 02:20:17,920
THIS ONE IS A NEW IDEA THAT CAME

3393
02:20:17,920 --> 02:20:20,960
UP A COUPLE OF YEARS BACK WITH

3394
02:20:20,960 --> 02:20:23,320
THE RECOGNITION THAT MYOFACIAL

3395
02:20:23,320 --> 02:20:25,680
PAIN IS PROBABLY ASSOCIATED WITH

3396
02:20:25,680 --> 02:20:27,320
OR UNDERLYING MANY, MANY

3397
02:20:27,320 --> 02:20:29,880
DIFFERENCE TYPES OF CHRONIC

3398
02:20:29,880 --> 02:20:32,120
PAIN, SO MYOFACIAL PAIN COULD BE

3399
02:20:32,120 --> 02:20:34,720
PAIN ASSOCIATED MANY THE MUSCLE

3400
02:20:34,720 --> 02:20:38,520
TISSUE, THE OTHER SOFT TISSUES,

3401
02:20:38,520 --> 02:20:41,560
IT PROBABLY HAS AN INTERACTION

3402
02:20:41,560 --> 02:20:43,400
WITH NEUROIMMUNE SYSTEMS, IF YOU

3403
02:20:43,400 --> 02:20:45,680
THINK OF THE CONDITIONS WHERE IT

3404
02:20:45,680 --> 02:20:49,280
WOULD BE MOST LIKELY A LARGE

3405
02:20:49,280 --> 02:20:51,640
CONTRIBUTOR, MAY INCLUDE BACK

3406
02:20:51,640 --> 02:20:54,160
PAIN, TEMPORAL MANDIBULAR KISS

3407
02:20:54,160 --> 02:20:55,760
ORDERS, NECK PAIN SHOULDER PAIN

3408
02:20:55,760 --> 02:20:58,440
HEADACHE. SO IT SEEMED LIKE AN

3409
02:20:58,440 --> 02:21:02,160
IMPORTANT AREA OF RESEARCH AND

3410
02:21:02,160 --> 02:21:06,520
THESE BIOMARKERS WILL BE

3411
02:21:06,520 --> 02:21:09,400
PREDICTIVE AND PROGNOSTIC

3412
02:21:09,400 --> 02:21:11,840
HELPFUL IN CLINICAL TRIALS, AND

3413
02:21:11,840 --> 02:21:14,040
ARE BEING LOOKING FOR BIOMARKERS

3414
02:21:14,040 --> 02:21:16,280
THAT WOULD BE FOUND THROUGH

3415
02:21:16,280 --> 02:21:19,720
FAIRLY NOT INVASIVE TYPES OF

3416
02:21:19,720 --> 02:21:22,760
IMAGING AND OTHER WAYS TO

3417
02:21:22,760 --> 02:21:24,440
COLLECT BIOMARKERS. WE HAD --

3418
02:21:24,440 --> 02:21:25,280
MOVING THE RIGHT HAND SIDE OF

3419
02:21:25,280 --> 02:21:27,440
THE SLIDE, EARLY BIOMARKERS

3420
02:21:27,440 --> 02:21:31,080
PROGRAM, WHERE WE FUNDED EIGHT

3421
02:21:31,080 --> 02:21:33,040
DIFFERENT PROJECTS TO LOOK AT

3422
02:21:33,040 --> 02:21:34,960
EIGHT DIFFERENT TYPES OF PAIN.

3423
02:21:34,960 --> 02:21:37,920
MOST OF THESE WERE FOR

3424
02:21:37,920 --> 02:21:40,480
PROGNOSTIC BIOMARKERS, ONE FOR

3425
02:21:40,480 --> 02:21:42,320
DIAGNOSTIC AND BECAUSE WE GOT SO

3426
02:21:42,320 --> 02:21:44,400
MANY, WE HAVE SO MANY UNDERWAY,

3427
02:21:44,400 --> 02:21:46,840
AND FOR OTHER REASONS WE HAVE

3428
02:21:46,840 --> 02:21:48,880
REALIGNED THE PROGRAM TO LOOK AT

3429
02:21:48,880 --> 02:21:50,040
BIOMARKERS THAT WILL BE TARGETED

3430
02:21:50,040 --> 02:21:55,160
MORE FOR USE IN EARLY CLINICAL

3431
02:21:55,160 --> 02:21:56,000
TRIALS. THESE WILL BE RESPONSE

3432
02:21:56,000 --> 02:21:58,160
PREDICTION MONITORING

3433
02:21:58,160 --> 02:22:00,200
SIGNATURES, THAT COULD BE

3434
02:22:00,200 --> 02:22:03,680
ALIGNED WITH COMING THROUGH FOR

3435
02:22:03,680 --> 02:22:07,240
EVALUATION IN EPIC NET. ONE OF

3436
02:22:07,240 --> 02:22:09,080
THE REALLY EXCITING

3437
02:22:09,080 --> 02:22:10,800
ACCOMPLISHMENTS I THINK FROM THE

3438
02:22:10,800 --> 02:22:12,360
EARLY BIOMARKER PROGRAM IS THERE

3439
02:22:12,360 --> 02:22:15,360
IS A DIAGNOSTIC BIOMARKER DOING

3440
02:22:15,360 --> 02:22:17,440
WELL IN ITS FIRST PHASE OF

3441
02:22:17,440 --> 02:22:20,280
STUDY, THAT WILL HELP

3442
02:22:20,280 --> 02:22:22,360
DIFFERENTIATE FROM NEUROPATHIC

3443
02:22:22,360 --> 02:22:23,880
CORNEAL PAIN, THEY ARE HARD TO

3444
02:22:23,880 --> 02:22:25,360
DIAGNOSE, ONE FROM THE -- THAT

3445
02:22:25,360 --> 02:22:28,000
NEED TO BE TREATED DIFFERENTLY.

3446
02:22:28,000 --> 02:22:32,040
SO THIS IS CONFOCAL MICROSCOPY,

3447
02:22:32,040 --> 02:22:32,640
RAPID COLLECTION COLLECTION OF

3448
02:22:32,640 --> 02:22:34,440
IMAGING AND DEEP LEARNING SYSTEM

3449
02:22:34,440 --> 02:22:40,640
TO LOOK AT THOSE IMAGES AND BE

3450
02:22:40,640 --> 02:22:43,160
ABLE TO DETECT MICRONEUROMAS IN

3451
02:22:43,160 --> 02:22:45,720
THE CORNEAL AREA AND GIVE A

3452
02:22:45,720 --> 02:22:50,440
POSITIVE DIAGNOSTIC FOR IT BEING

3453
02:22:50,440 --> 02:22:53,400
ACTUALLY NEUROPATHIC CORNEAL

3454
02:22:53,400 --> 02:22:53,960
PAIN.

3455
02:22:53,960 --> 02:22:56,000
>> LINDA, I DON'T KNOW IF
YOU

3456
02:22:56,000 --> 02:22:57,400
ARE NEARING THE END BUT WE ARE

3457
02:22:57,400 --> 02:22:58,800
-- I WANT TO MAKE SURE THERE'S

3458
02:22:58,800 --> 02:23:01,600
TIME FOR QUESTIONS AND I KNOW

3459
02:23:01,600 --> 02:23:03,000
MICHAEL HAS A LOT AS WELL.

3460
02:23:03,000 --> 02:23:04,960
>> I'M GOING TO BE RIGHT
IN MY

3461
02:23:04,960 --> 02:23:06,560
20 MINUTES, BOB. 

3462
02:23:06,560 --> 02:23:12,480
>> ACTUALLY IT'S -- OKAY.
GO.

3463
02:23:12,480 --> 02:23:17,720
>> SO WE HAVE ADVANCING
HEALTH

3464
02:23:17,720 --> 02:23:20,120
EQUITY, THIS PROGRAM LOOKS AT

3465
02:23:20,120 --> 02:23:22,680
WHY WE HAVE DISPARITIES IN

3466
02:23:22,680 --> 02:23:25,600
HEALTHCARE BECAUSE OF INDIVIDUAL

3467
02:23:25,600 --> 02:23:26,800
FACTORS INTERPERSONAL FACTOR,

3468
02:23:26,800 --> 02:23:29,160
HEALTHCARE SYSTEM FACTORS AND WE

3469
02:23:29,160 --> 02:23:34,440
ARE LOOKING TO FUND ABOUT 4 TO 6

3470
02:23:34,440 --> 02:23:36,640
TRIALS LATER THIS YEAR THAT

3471
02:23:36,640 --> 02:23:40,400
COVER A NUMBER OF DIFFERENT

3472
02:23:40,400 --> 02:23:42,280
RACIAL ETHNIC GROUPS

3473
02:23:42,280 --> 02:23:43,520
MARGINALIZED AND HAVE HEALTHCARE

3474
02:23:43,520 --> 02:23:51,960
DISPARITIES.  I'M STUCK AGAIN.

3475
02:23:51,960 --> 02:23:54,120
WE HAVE A NEW PROGRAM THROUGH

3476
02:23:54,120 --> 02:23:56,880
HEAL ON PATIENT ENGAGEMENT WHERE

3477
02:23:56,880 --> 02:23:58,560
WE HAVE AN ADVISORY BOARD OF

3478
02:23:58,560 --> 02:24:00,560
PATIENTS ADVOCATES, FAMILY

3479
02:24:00,560 --> 02:24:04,080
MEMBERS TO HELP US WORK THROUGH

3480
02:24:04,080 --> 02:24:06,200
HOW WE CAN BETTER MAKE OUR

3481
02:24:06,200 --> 02:24:08,920
TRIALS AND OUR PROGRAMS MORE

3482
02:24:08,920 --> 02:24:11,560
MEANINGFUL TO PATIENTS AND OTHER

3483
02:24:11,560 --> 02:24:14,040
STAKEHOLDERS AS FAR AS OUTCOMES

3484
02:24:14,040 --> 02:24:16,640
GO. THEY HAVE BEEN HUGELY

3485
02:24:16,640 --> 02:24:18,880
HELPFUL. CHRIS VEASLEY THANK YOU

3486
02:24:18,880 --> 02:24:20,840
FOR JOINING US ON THIS PANEL AS

3487
02:24:20,840 --> 02:24:23,960
WELL AS ON THE COUNCIL HERE. 

3488
02:24:23,960 --> 02:24:25,600
THIS SLIDE YOU SAW THIS IS JUST

3489
02:24:25,600 --> 02:24:27,920
A QUICK REMINDER OF THE KIND OF

3490
02:24:27,920 --> 02:24:29,960
EFFORTS WE ARE PUTTING INTO DATA

3491
02:24:29,960 --> 02:24:32,480
HARMONIZATION FOR ALL THE

3492
02:24:32,480 --> 02:24:33,560
CLINICAL STUDIES WE HAVE A

3493
02:24:33,560 --> 02:24:37,000
NUMBER OF DOMAINS, WHERE PATH TO

3494
02:24:37,000 --> 02:24:38,800
COLLECT CERTAIN PROs FOR THE

3495
02:24:38,800 --> 02:24:40,240
STUDIES, THEY ARE ALL

3496
02:24:40,240 --> 02:24:41,400
HARMONIZED.  THEY WILL BE GREAT

3497
02:24:41,400 --> 02:24:44,200
FOR LATER EVALUATION OF DATA IN

3498
02:24:44,200 --> 02:24:47,200
A VERY MEANINGFUL WAY. THIS

3499
02:24:47,200 --> 02:24:50,920
SLIDE SUMS UP WHAT WHAT WE HAVE

3500
02:24:50,920 --> 02:24:53,240
ACROSS THE DISCOVERY, THE PHASE

3501
02:24:53,240 --> 02:24:55,320
2 COMPARATIVE EFFECTIVENESS AND

3502
02:24:55,320 --> 02:24:59,680
IMPLEMENTATION TYPE OF RESEARCH

3503
02:24:59,680 --> 02:25:01,200
ACROSS THE DIFFERENT PROGRAMS.

3504
02:25:01,200 --> 02:25:04,840
WE ARE LOOKING AT TWO BRAND NEW

3505
02:25:04,840 --> 02:25:08,360
PROGRAMS IN FY 23, FOUR, TWO ON

3506
02:25:08,360 --> 02:25:09,760
EACH SLIDE, ONE TO LOOK AT

3507
02:25:09,760 --> 02:25:10,960
BETTER PAIN MANAGEMENT AND RURAL

3508
02:25:10,960 --> 02:25:15,440
POPULATIONS.  AND SO ANOTHER IS

3509
02:25:15,440 --> 02:25:17,200
SICKLE CELL DISEASE, WE THINK

3510
02:25:17,200 --> 02:25:19,920
THESE WILL BOTH REALLY BE

3511
02:25:19,920 --> 02:25:21,440
APPLICABLE TO UNDER-REPRESENTED

3512
02:25:21,440 --> 02:25:22,600
POPULATIONS AND THOSE WITH

3513
02:25:22,600 --> 02:25:25,880
HEALTH DISPARITIES.  WE ARE ALSO

3514
02:25:25,880 --> 02:25:28,560
LOOKING AT A PROGRAM FOR

3515
02:25:28,560 --> 02:25:32,160
COORDINATED CARE IN HEALTHCARE

3516
02:25:32,160 --> 02:25:33,320
SYSTEMS WE INTEGRATE PRIMARY

3517
02:25:33,320 --> 02:25:36,680
CARE WITH SPECIALTY CARE SYSTEMS

3518
02:25:36,680 --> 02:25:37,760
AND HEALTHCARE SYSTEMS WHERE

3519
02:25:37,760 --> 02:25:39,160
THIS COORDINATED CARE DOESN'T

3520
02:25:39,160 --> 02:25:41,680
EXIST. IT WILL BE

3521
02:25:41,680 --> 02:25:43,680
MULTI-DISCIPLINARY BASED ON

3522
02:25:43,680 --> 02:25:44,800
BIOPSYCHOSOCIAL MODEL OF PAIN.

3523
02:25:44,800 --> 02:25:47,040
SIMILAR TO THE EMPOWER ACCEPT

3524
02:25:47,040 --> 02:25:49,240
THIS WILL BE PAIN AND INTEGRATED

3525
02:25:49,240 --> 02:25:51,440
THERAPY FOR THOSE AT RISK.  FOR

3526
02:25:51,440 --> 02:25:55,240
OUD.  VERY COMPLICATED PROGRAM.

3527
02:25:55,240 --> 02:25:56,440
THE ONLY OTHER THING I WANT TO

3528
02:25:56,440 --> 02:25:58,880
MENTION IS THAT WE HAVE SOME

3529
02:25:58,880 --> 02:26:00,360
REALLY IMPORTANT PROGRAMS THAT

3530
02:26:00,360 --> 02:26:02,680
ARE PROVING TOWARDS IMPROVING

3531
02:26:02,680 --> 02:26:04,880
THE WORK FORCE WE HAVE A

3532
02:26:04,880 --> 02:26:07,520
MENTORING PROGRAM WE MADE FOUR

3533
02:26:07,520 --> 02:26:10,120
AWARDS TO INVESTIGATORS TO SERVE

3534
02:26:10,120 --> 02:26:11,720
PROTECTED TIME TO SERVE AS

3535
02:26:11,720 --> 02:26:14,600
MENTORS. WE HAVE A TRAINING

3536
02:26:14,600 --> 02:26:15,960
PROGRAM FOR YOUNG SCHOLARS TO

3537
02:26:15,960 --> 02:26:17,440
MOVE INTO CLINICAL PAIN RESEARCH

3538
02:26:17,440 --> 02:26:19,240
AND WE HAVE A NATIONAL K 12

3539
02:26:19,240 --> 02:26:21,600
COMING UP WHICH WE RA REALLY

3540
02:26:21,600 --> 02:26:23,960
EXCITED ABOUT WHERE WE WILL

3541
02:26:23,960 --> 02:26:26,640
BRING IN SCHOLARS, PROVIDE THEM

3542
02:26:26,640 --> 02:26:28,320
WITH SUPPORT FOR RESEARCH BUT

3543
02:26:28,320 --> 02:26:30,280
ALSO HAVE A NETWORKING SYSTEM

3544
02:26:30,280 --> 02:26:32,480
WHERE WE CAN LINK UP

3545
02:26:32,480 --> 02:26:34,320
PRE-CLINICAL TRANSLATIONAL AND

3546
02:26:34,320 --> 02:26:37,720
CLINICAL RESEARCHERS TO HAVE

3547
02:26:37,720 --> 02:26:39,320
THEIR CONVERSATIONS TO APPROVE

3548
02:26:39,320 --> 02:26:42,520
OUTCOMES.  IN THE RESEARCH

3549
02:26:42,520 --> 02:26:44,160
ENDEAVORS AND SO I THINK AT THIS

3550
02:26:44,160 --> 02:26:45,800
POINT I WILL TURN TO MICHAEL, IF

3551
02:26:45,800 --> 02:26:47,720
WE HAVE TIME FOR QUESTIONS AT

3552
02:26:47,720 --> 02:26:50,680
THE END WE CAN DO IT SO MICHAEL,

3553
02:26:50,680 --> 02:26:54,240
GO PICK UP FROM HERE.

3554
02:26:54,240 --> 02:26:55,680
>> ANY QUESTIONS YOU HAVE
YOU

3555
02:26:55,680 --> 02:26:57,600
CAN ASK THEM AT THE END.

3556
02:26:57,600 --> 02:27:05,440
>> THANK YOU, LINDA. SLIDE
HERE

3557
02:27:05,440 --> 02:27:07,800
THEN SHARE, THAT LOOK OKAY FOR

3558
02:27:07,800 --> 02:27:08,080
EVERYBODY?

3559
02:27:08,080 --> 02:27:09,880
>> YES, IT DOES.

3560
02:27:09,880 --> 02:27:12,400
>> I CAN'T SPEAK FOR
EVERYBODY. 

3561
02:27:12,400 --> 02:27:14,040
>> I HAVE A LOT TO SPEAK
ABOUT

3562
02:27:14,040 --> 02:27:15,960
SO I WILL SPEAK QUICKLY. AS

3563
02:27:15,960 --> 02:27:17,080
LINDA MENTIONED WILL SAVE ALL

3564
02:27:17,080 --> 02:27:18,720
THE QUESTIONS FOR THE END SO WE

3565
02:27:18,720 --> 02:27:20,720
CAN GET THROUGH ALL THESE MANY

3566
02:27:20,720 --> 02:27:23,160
PROGRAMS THAT WE ARE PROUD OF

3567
02:27:23,160 --> 02:27:26,720
HERE IN THE ANYONE HEAL

3568
02:27:26,720 --> 02:27:27,600
INITIATIVE, SPECIFICALLY IN THIS

3569
02:27:27,600 --> 02:27:30,800
CASE IN THE PRE-CLINICAL AND

3570
02:27:30,800 --> 02:27:35,240
TRANSLATIONAL WORK GROUP. NINDS

3571
02:27:35,240 --> 02:27:37,680
PARTICIPATION IN HEAL IS MAINLY

3572
02:27:37,680 --> 02:27:40,960
IN THE ENHANCING PAIN MANAGEMENT

3573
02:27:40,960 --> 02:27:42,320
GOAL PORTION OF HEAL. THAT IS

3574
02:27:42,320 --> 02:27:45,720
REALLY BROKEN INTO FOUR PIECES,

3575
02:27:45,720 --> 02:27:47,680
UNDERSTANDING THE BIOLOGICAL

3576
02:27:47,680 --> 02:27:48,640
UNDERPINNINGS OF CHRONIC

3577
02:27:48,640 --> 02:27:51,160
PLANNING AN ACCELERATING THE

3578
02:27:51,160 --> 02:27:51,760
DISCOVERY AND CLINICAL

3579
02:27:51,760 --> 02:27:54,080
DEVELOPMENT OF NON-ADDICTIVE

3580
02:27:54,080 --> 02:27:54,840
PAIN TREATMENT FIRST TWO BULLET

3581
02:27:54,840 --> 02:27:58,080
POINTS IS WHAT WE ARE FOCUSING

3582
02:27:58,080 --> 02:28:00,720
ON IN THE INITIATIVES AND

3583
02:28:00,720 --> 02:28:03,360
PROGRESS IN HOSE INITIATIVES I

3584
02:28:03,360 --> 02:28:05,640
WILL SPEAK ABOUT NOW. THE LAST

3585
02:28:05,640 --> 02:28:08,320
TWO BULLET POINTS, LINDA,

3586
02:28:08,320 --> 02:28:10,440
ADDRESSED IN HER PRESENTATION.

3587
02:28:10,440 --> 02:28:12,040
SO LET'S TALK ABOUT A FEW OF THE

3588
02:28:12,040 --> 02:28:14,400
WINS THAT WE HAVE SEEN SO FAR

3589
02:28:14,400 --> 02:28:16,280
INSIDE THE PROJECTS AND

3590
02:28:16,280 --> 02:28:18,200
INITIATIVES THAT WE HAVE BEEN

3591
02:28:18,200 --> 02:28:20,120
SUPPORTING IN THE HEAL

3592
02:28:20,120 --> 02:28:21,720
PRE-CLINICAL TRANSLATIONAL PAIN

3593
02:28:21,720 --> 02:28:23,800
RESEARCH PORTION.  INITIAL

3594
02:28:23,800 --> 02:28:25,680
AWARDS CAME OUT IN FY 18 BUT

3595
02:28:25,680 --> 02:28:28,000
THAT WAS A SMALL AMOUNT OF MONEY

3596
02:28:28,000 --> 02:28:30,200
SO WE ARE TALKING ABOUT THE

3597
02:28:30,200 --> 02:28:31,280
RESEARCH THAT WAS AND FUNDING

3598
02:28:31,280 --> 02:28:37,560
GONE OUT IN FY 19 THROUGH 21,

3599
02:28:37,560 --> 02:28:39,640
THAT'S $335 MILLION, TWO OF

3600
02:28:39,640 --> 02:28:42,240
THOSE YEARS WERE DURING COVID.  

3601
02:28:42,240 --> 02:28:44,400
BUT WE HAVE ONE NEW DRUG IND FOR

3602
02:28:44,400 --> 02:28:46,400
A FIRST IN CLASS NON-ADDICTIVE

3603
02:28:46,400 --> 02:28:48,720
DRUG TO TREAT PAIN, WE HAVE FIVE

3604
02:28:48,720 --> 02:28:51,400
NEW IDEs FOR DEVICES, TO

3605
02:28:51,400 --> 02:28:52,400
CLINICAL TRIALS AND CLINICAL

3606
02:28:52,400 --> 02:28:56,040
RESEARCH TO STUDY DEVICES FOR

3607
02:28:56,040 --> 02:28:57,640
TREATING PAIN, WE HAVE SEVEN

3608
02:28:57,640 --> 02:28:59,640
PATENTS ON THE SBIR FUNDING,

3609
02:28:59,640 --> 02:29:02,960
THAT IS FOCUSED ON THERAPEUTICS

3610
02:29:02,960 --> 02:29:04,600
AND ANALGESIC DEVELOPMENT. WE

3611
02:29:04,600 --> 02:29:06,360
HAVE TWO PATENTS FOR SMALL

3612
02:29:06,360 --> 02:29:08,080
MOLECULE MODULATORS AN PANDORE

3613
02:29:08,080 --> 02:29:09,360
ACCEPTORS FROM OUR TARGET

3614
02:29:09,360 --> 02:29:10,800
DISCOVERY PROGRAM THAT, IS IN

3615
02:29:10,800 --> 02:29:13,320
OUR RO1 POOL SUPPORTED BY THESE

3616
02:29:13,320 --> 02:29:14,760
PROGRAMS. WE HAVE FIVE SMALL

3617
02:29:14,760 --> 02:29:16,960
BUSINESS THERAPIES THAT PRECEDED

3618
02:29:16,960 --> 02:29:20,280
TO THE CLINICAL STAGE AND ONE

3619
02:29:20,280 --> 02:29:22,120
PHASE 1 TRIAL COMPLETED DURING

3620
02:29:22,120 --> 02:29:23,760
-- IN ONE OF THE THERAPEUTICS

3621
02:29:23,760 --> 02:29:25,640
DEVELOPMENT PROJECTS BUT THAT IS

3622
02:29:25,640 --> 02:29:28,200
A LOT OF WINS IN TWO PLUS YEARS,

3623
02:29:28,200 --> 02:29:31,560
WE ARE VERY PROUD OF THAT. WE

3624
02:29:31,560 --> 02:29:32,760
ALSO SUPPORTED IN COLLABORATION

3625
02:29:32,760 --> 02:29:34,800
WITH THE INTRAMURAL RESEARCHERS

3626
02:29:34,800 --> 02:29:36,960
AT NCATS DEVELOPING NEW

3627
02:29:36,960 --> 02:29:39,040
SCREENING PLATFORMS, TESTING

3628
02:29:39,040 --> 02:29:41,480
PLATFORMS, DISCOVERING

3629
02:29:41,480 --> 02:29:42,640
ANALGESICS FOR PAIN, DEVELOPING

3630
02:29:42,640 --> 02:29:45,320
TISSUE CHIPS USED FOR SIMILAR

3631
02:29:45,320 --> 02:29:46,680
PURPOSES, AND FOR OPTIMIZATION

3632
02:29:46,680 --> 02:29:48,840
RESEARCH ON THESE THERAPEUTICS

3633
02:29:48,840 --> 02:29:51,680
ELEMENT. A LOT OF THE PROGRAMS

3634
02:29:51,680 --> 02:29:54,360
WE HAVE ONGOING INSIDE OF HEAL

3635
02:29:54,360 --> 02:29:55,640
MANY THE PRE-CLINICAL SPACE AND

3636
02:29:55,640 --> 02:29:57,400
THE ONES THAT WE LIKE TO BRING

3637
02:29:57,400 --> 02:29:59,720
TO YOU FOR CONCEPT CLEARANCE ARE

3638
02:29:59,720 --> 02:30:02,440
TEAM BASED, BRINGING INDIVIDUALS

3639
02:30:02,440 --> 02:30:03,920
WITH DIFFERENT TYPES OF

3640
02:30:03,920 --> 02:30:07,160
EXPERTISE THAT SOME OF THAT WAS

3641
02:30:07,160 --> 02:30:08,960
MENTIONED EARLIER IN CASE OF

3642
02:30:08,960 --> 02:30:10,360
DISCUSSIONS HAVING CLINICS

3643
02:30:10,360 --> 02:30:11,800
COLLABORATING WITH BASIC

3644
02:30:11,800 --> 02:30:13,600
SCIENTIST AROUND PARTICULAR

3645
02:30:13,600 --> 02:30:14,840
THERAPEUTIC CONDITION. THAT'S

3646
02:30:14,840 --> 02:30:16,200
WHAT WE ARE SUPPORTIVE OF AND

3647
02:30:16,200 --> 02:30:17,680
INCLUDING IN THE FUNDING

3648
02:30:17,680 --> 02:30:19,840
ANNOUNCEMENTS FOR HEAL. OF

3649
02:30:19,840 --> 02:30:22,520
COURSE THE PAIN WORK FORCE

3650
02:30:22,520 --> 02:30:23,320
ENHANCEMENT IN GETTING MORE

3651
02:30:23,320 --> 02:30:26,040
PEOPLE IN AND EARLIER STAGES

3652
02:30:26,040 --> 02:30:27,720
SPORING THEM SO THEY CAN GET

3653
02:30:27,720 --> 02:30:30,120
THEIR RO1s IN AND THERAPEUTIC

3654
02:30:30,120 --> 02:30:33,120
DEVELOPMENT PROGRAMS STARTED. SO

3655
02:30:33,120 --> 02:30:35,520
THIS IS ANOTHER VARIATION OF

3656
02:30:35,520 --> 02:30:36,480
THAT CHEVRON DIAGRAM, LITTLE

3657
02:30:36,480 --> 02:30:38,240
MORE DETAIL THAN WE HAVE SEEN

3658
02:30:38,240 --> 02:30:39,960
BEFORE, CON ENTRAIT ON UPPER

3659
02:30:39,960 --> 02:30:41,280
LEFT HAND CORNER HERE, THE

3660
02:30:41,280 --> 02:30:43,560
TARGET DISCOVERY VALIDATION

3661
02:30:43,560 --> 02:30:44,760
PROJECT, THESE HAVE BEEN FEEDING

3662
02:30:44,760 --> 02:30:48,200
AND LEADING TO PLANNING STUDY

3663
02:30:48,200 --> 02:30:49,640
FOR INITIAL ANALGESIC

3664
02:30:49,640 --> 02:30:52,360
DEVELOPMENT, WE HAVE SEEN THAT

3665
02:30:52,360 --> 02:30:54,720
HAPPEN. THESE PLANNING STUDIES

3666
02:30:54,720 --> 02:30:57,680
ARE WHO YEAR STUDIES THAT THEN

3667
02:30:57,680 --> 02:31:00,360
PREPARE INDIVIDUALS TO APPLY FOR

3668
02:31:00,360 --> 02:31:02,040
THESE FIVE YEAR PROGRAMS FOR THE

3669
02:31:02,040 --> 02:31:04,920
INITIAL TRANSLATIONAL EFFORTS

3670
02:31:04,920 --> 02:31:06,160
AND NON-ADDICTIVE ANALGESIC

3671
02:31:06,160 --> 02:31:07,920
THERAPEUTIC DEVELOPMENT, THEN WE

3672
02:31:07,920 --> 02:31:10,520
HAVE THE PTDP PROGRAM, THE PAIN

3673
02:31:10,520 --> 02:31:12,280
THERAPEUTIC DEVELOPMENT PROGRAM

3674
02:31:12,280 --> 02:31:15,560
WHICH MIRRORS NIH VERY

3675
02:31:15,560 --> 02:31:19,040
SUCCESSFUL BLUE

3676
02:31:19,040 --> 02:31:20,480
NEURONEUROTHERAPEUTIC PROGRAM,

3677
02:31:20,480 --> 02:31:23,080
OPTIMIZING GETTING READY FOR IND

3678
02:31:23,080 --> 02:31:25,000
SESSION IN PHASE 1 CLINICAL

3679
02:31:25,000 --> 02:31:25,600
TRIALS, IN THIS CASE SUPPORT

3680
02:31:25,600 --> 02:31:27,560
THOSE STUDIES IN PHASE 1

3681
02:31:27,560 --> 02:31:28,600
CLINICAL TRIALS INSIDE THERE.

3682
02:31:28,600 --> 02:31:31,880
THERE ARE DEVICE PROGRAMS WITH

3683
02:31:31,880 --> 02:31:33,680
SEVERAL FUNDING ANNOUNCEMENTS. 

3684
02:31:33,680 --> 02:31:35,080
ONE OF THE STREET HERE BUT HAS

3685
02:31:35,080 --> 02:31:36,880
MANY COMPONENTS, VERY PROUD OF

3686
02:31:36,880 --> 02:31:39,000
THE WORK THAT IS GOING ON IN

3687
02:31:39,000 --> 02:31:40,880
THERE, PRE-CLINICAL DEVELOPMENT

3688
02:31:40,880 --> 02:31:43,240
AND EVEN CLINICAL TRIALS IN

3689
02:31:43,240 --> 02:31:44,920
THESE REALLY PROJECTS THAT ARE

3690
02:31:44,920 --> 02:31:47,080
BASED ON DEVICES THAT HAVE

3691
02:31:47,080 --> 02:31:49,160
TREMENDOUS POTENTIAL TO HAVE LOW

3692
02:31:49,160 --> 02:31:49,800
ADDICTION LIABILITY BUT CHANGE

3693
02:31:49,800 --> 02:31:52,280
THE LIVES OF THESE PATIENTS. WE

3694
02:31:52,280 --> 02:31:56,160
ALSO HAVE THE PRE-CLINICAL

3695
02:31:56,160 --> 02:31:57,360
STREAMING PAIN, I WILL GIVE YOU

3696
02:31:57,360 --> 02:31:59,240
DETAILS WITH SLIDES LATER ON FOR

3697
02:31:59,240 --> 02:32:01,320
THAT AND EPIC NET IS OUR PHASE 2

3698
02:32:01,320 --> 02:32:02,760
CLINICAL TRIALS PROGRAM THAT

3699
02:32:02,760 --> 02:32:05,040
LINDA GAVE YOU DETAILS ON WHAT

3700
02:32:05,040 --> 02:32:06,000
STAGE THEY ARE AT.

3701
02:32:06,000 --> 02:32:07,080
LET'S NOT FORGET WE HAVE THE

3702
02:32:07,080 --> 02:32:09,120
INTRAMURAL RESEARCHERS AT NCATS

3703
02:32:09,120 --> 02:32:13,760
IN COLLABORATION WITH EXTERNAL

3704
02:32:13,760 --> 02:32:15,120
COMMUNITY SUPPORTING THE

3705
02:32:15,120 --> 02:32:17,840
DEVELOPMENT OF TISSUE CHIPS.

3706
02:32:17,840 --> 02:32:21,960
IPSC CELLS, BASED ON NOCICEPTORS

3707
02:32:21,960 --> 02:32:25,760
TO REALLY THESE IPSC CELLS THAT

3708
02:32:25,760 --> 02:32:27,680
MIMIC NOCICEPTORS TO PROVIDE

3709
02:32:27,680 --> 02:32:29,080
PLATFORMS FOR SCREENING TENS OR

3710
02:32:29,080 --> 02:32:30,280
HUNDREDS OF THOUSANDS OF

3711
02:32:30,280 --> 02:32:32,560
POTENTIAL COMPOUNDS FOR TREATING

3712
02:32:32,560 --> 02:32:34,480
PAIN. WE HAVE NEW PROGRAMS

3713
02:32:34,480 --> 02:32:36,240
PRECISION HUMAN PAIN NETWORK AND

3714
02:32:36,240 --> 02:32:37,840
ALSO THE REJOIN PROGRAM, I WILL

3715
02:32:37,840 --> 02:32:43,840
GIVE YOU SOME DETAILS ON. SO LET

3716
02:32:43,840 --> 02:32:46,760
ME SHOW YOU HOW THESE PROGRAMS

3717
02:32:46,760 --> 02:32:49,200
FIT TOGETHER AND HOW THE PAIN

3718
02:32:49,200 --> 02:32:50,120
DISCOVERY AND TARGET PROGRAM

3719
02:32:50,120 --> 02:32:52,320
WHICH IS AN RO1 THERE IS AN OPEN

3720
02:32:52,320 --> 02:32:55,280
ENDED BUT FOCUS ON VALIDATING

3721
02:32:55,280 --> 02:32:56,960
PARTICULAR TARGET TO THEN LEAD

3722
02:32:56,960 --> 02:32:59,280
TO THIS PLANNING STUDY TO BUILD

3723
02:32:59,280 --> 02:33:01,920
A TEAM AROUND DEVELOPING A

3724
02:33:01,920 --> 02:33:02,960
THERAPEUTIC PROGRAM, BRINGING

3725
02:33:02,960 --> 02:33:04,920
THOSE INDIVIDUALS IN, WHO HAVE

3726
02:33:04,920 --> 02:33:07,080
EXPERTISE IN DEVELOPING SMALL

3727
02:33:07,080 --> 02:33:08,640
MOLECULES OR BIOLOGICS AND

3728
02:33:08,640 --> 02:33:11,280
DEVELOPING SCREENING TO ASK THE

3729
02:33:11,280 --> 02:33:13,080
QUESTION WHETHER OR NOT THEY CAN

3730
02:33:13,080 --> 02:33:14,640
HAPPEN, WHETHER OR NOT THEY CAN

3731
02:33:14,640 --> 02:33:17,280
BE EFFECT, BIOLOGICAL EFFECT OF

3732
02:33:17,280 --> 02:33:18,960
PARTICULAR MOLECULE OR ASSET

3733
02:33:18,960 --> 02:33:21,000
THEY DEVELOPING, AROUND

3734
02:33:21,000 --> 02:33:23,000
PARTICULAR RECEPTOR AND THEN

3735
02:33:23,000 --> 02:33:25,520
ALSO INCLUDING EXPERTS IN USING

3736
02:33:25,520 --> 02:33:27,240
ANIMAL MODELS FOR ASKING

3737
02:33:27,240 --> 02:33:29,600
QUESTIONS ABOUT THE EFFICACY OF

3738
02:33:29,600 --> 02:33:32,400
PAIN THERAPEUTICS. BUILDING THAT

3739
02:33:32,400 --> 02:33:35,040
TEAM TOGETHER AND THEN

3740
02:33:35,040 --> 02:33:36,960
INITIATING THERAPEUTICS

3741
02:33:36,960 --> 02:33:38,480
DISCOVERY PROGRAM AROUND A

3742
02:33:38,480 --> 02:33:40,400
PARTICULAR TARGET. THEN WHEN

3743
02:33:40,400 --> 02:33:42,480
THEY FOUND HIT TO LEAD AND THEY

3744
02:33:42,480 --> 02:33:44,280
HAVE A STRONG BIOLOGICAL

3745
02:33:44,280 --> 02:33:47,280
RATIONALE THEY CAN SUBMIT TO THE

3746
02:33:47,280 --> 02:33:50,160
PTTP PROGRAM, PAIN THERAPEUTIC

3747
02:33:50,160 --> 02:33:54,440
DISCOVERY PROGRAM, DEVELOPMENT

3748
02:33:54,440 --> 02:33:55,120
PROGRAM, THAT WILL TAKE THEM

3749
02:33:55,120 --> 02:33:58,920
THROUGH IND AND PHASE 1 CLINICAL

3750
02:33:58,920 --> 02:34:00,160
TRIALS AND GET READY FOR EPIC

3751
02:34:00,160 --> 02:34:02,960
NET. THE PSDP PROGRAM CAN HELP

3752
02:34:02,960 --> 02:34:05,800
AT ANY STAGE HERE AND THE SBIR

3753
02:34:05,800 --> 02:34:07,360
WE SEE A LOT OF WORK IN THAT

3754
02:34:07,360 --> 02:34:09,680
AREA, AND A LOT OF INTEREST IN

3755
02:34:09,680 --> 02:34:13,800
THE SDIRs AND THEY CAN ALSO

3756
02:34:13,800 --> 02:34:15,640
TAKE ADVANTAGE OF EITHER THE

3757
02:34:15,640 --> 02:34:17,440
INITIAL THERAPEUTICS PROGRAM OR

3758
02:34:17,440 --> 02:34:19,160
LATER STAGE AFTER THEY GET THEIR

3759
02:34:19,160 --> 02:34:21,920
HIT TO LEAD. WE SEE INTEGRATING.

3760
02:34:21,920 --> 02:34:24,520
RIGHT NOW INSIDE THERAPEUTIC

3761
02:34:24,520 --> 02:34:26,000
VALIDATION OF THESE POTENTIAL

3762
02:34:26,000 --> 02:34:27,120
THERAPEUTIC TARGETS TO TREAT

3763
02:34:27,120 --> 02:34:29,240
PAIN THESE RO1s TO WORK UP THE

3764
02:34:29,240 --> 02:34:32,920
BIOLOGY BUT WORK UP BIOLOGY IN

3765
02:34:32,920 --> 02:34:37,160
THE CONTEXT OF VALIDATED TARGET,

3766
02:34:37,160 --> 02:34:38,800
I SEE YOU HAVE YOUR HAND UP DID

3767
02:34:38,800 --> 02:34:45,680
YOU WANT THE SAY SOMETHIN SOMETE

3768
02:34:45,680 --> 02:34:50,040
CURRENTLY HAVE WE HAVE 26 RO1s

3769
02:34:50,040 --> 02:34:51,680
FUNDED, TWO AND EIGHT

3770
02:34:51,680 --> 02:34:52,640
ADMINISTRATIVE SUPPLEMENTS THOSE

3771
02:34:52,640 --> 02:34:55,480
ARE PROJECTS BACK IN 2018, THOSE

3772
02:34:55,480 --> 02:34:57,440
WERE EASIEST ON THE STREET AND

3773
02:34:57,440 --> 02:35:00,280
WE ALREADY SEE AT LEAST ONE OF

3774
02:35:00,280 --> 02:35:03,640
THOSE PROGRAMS TAKING ADVANTAGE

3775
02:35:03,640 --> 02:35:05,960
OF LATER DEVELOPMENT FUNDING

3776
02:35:05,960 --> 02:35:07,120
OPPORTUNITIES INSIDE HEAL AND WE

3777
02:35:07,120 --> 02:35:08,840
HAVE SEVERAL PATENTS FROM THESE

3778
02:35:08,840 --> 02:35:11,160
GROUPS, ALREADY SUBMITTED.  WE

3779
02:35:11,160 --> 02:35:13,000
HAVE THE PLANNING GRANT AND THE

3780
02:35:13,000 --> 02:35:14,440
TEAM BASED RESEARCH FOR THAT

3781
02:35:14,440 --> 02:35:15,920
INITIAL THERAPEUTICS DEVELOPMENT

3782
02:35:15,920 --> 02:35:18,440
AND WHAT IS INTERESTING ABOUT

3783
02:35:18,440 --> 02:35:20,920
THIS PROGRAM, IT SUPPORTS

3784
02:35:20,920 --> 02:35:24,040
MULTIPLE PARTS OF THERAPEUTICS

3785
02:35:24,040 --> 02:35:26,480
DEVELOPMENT IN THE SAME

3786
02:35:26,480 --> 02:35:28,480
APPLICATION. SO THE GOAL HERE IS

3787
02:35:28,480 --> 02:35:31,760
THE GROUPS DON'T HAVE TO WRITE A

3788
02:35:31,760 --> 02:35:34,920
GRANT IN ORDER TO DEVELOP ASSAY,

3789
02:35:34,920 --> 02:35:35,520
BRIGHT A SEPARATE GRANT IN ORDER

3790
02:35:35,520 --> 02:35:37,480
FOR THEM TO DEVELOP PARTICULAR

3791
02:35:37,480 --> 02:35:39,200
ANIMAL MODEL THEY NEED IN ORDER

3792
02:35:39,200 --> 02:35:40,240
TO GET THEIR PROGRAM UP AND

3793
02:35:40,240 --> 02:35:44,920
RUNNING. SEPARATE AWARD TO

3794
02:35:44,920 --> 02:35:46,040
DEVELOP PHARMACODYNAMIC

3795
02:35:46,040 --> 02:35:47,520
BIOMARKERS WHICH ARE HELPFUL FOR

3796
02:35:47,520 --> 02:35:49,040
THESE SMALL MOLECULE AND

3797
02:35:49,040 --> 02:35:51,720
BIOLOGICAL DEVELOPMENT PROJECTS.

3798
02:35:51,720 --> 02:35:54,640
WE SPORT THE PKPD EFFICACY

3799
02:35:54,640 --> 02:35:57,960
STUDIES INSIDE ALL THIS ONE

3800
02:35:57,960 --> 02:35:59,960
PROJECT AND WE ARE EXCITED ABOUT

3801
02:35:59,960 --> 02:36:01,200
THAT PROGRAM, WE HOPE THAT WE

3802
02:36:01,200 --> 02:36:04,560
CAN GET MORE APPLICATIONS. I

3803
02:36:04,560 --> 02:36:06,160
WILL GIVE A REPORT HOW MANY

3804
02:36:06,160 --> 02:36:08,600
PROJECTS WE HAVE RUNNING BUT

3805
02:36:08,600 --> 02:36:09,920
RIGHT NOW WE HAVE SEVEN PROJECTS

3806
02:36:09,920 --> 02:36:11,680
SIX ARE PLANNING GRANTS AND ONE

3807
02:36:11,680 --> 02:36:14,920
IS A FUNDED U I, YOU SEE IF YOU

3808
02:36:14,920 --> 02:36:17,400
LOOK IN THE YELLOW HERE, WE HAVE

3809
02:36:17,400 --> 02:36:19,080
MULTIPLE SITES, THESE ARE

3810
02:36:19,080 --> 02:36:21,000
COLLABORATORY PROJECTS, AND WE

3811
02:36:21,000 --> 02:36:22,400
DON'T REQUIRE THEM TO BE AT THE

3812
02:36:22,400 --> 02:36:24,480
SAME INSTITUTION, WE ENCOURAGE

3813
02:36:24,480 --> 02:36:26,840
THEM TO USE THE BEST SCIENTISTS

3814
02:36:26,840 --> 02:36:28,800
IN ORDER TO CONTRIBUTE TO THAT

3815
02:36:28,800 --> 02:36:29,640
COMPONENT OF THE GRANT TO MAKE

3816
02:36:29,640 --> 02:36:31,800
IT THE MOST SUCCESSFUL. WE DON'T

3817
02:36:31,800 --> 02:36:33,680
SEE THAT IN THE APPLICATIONS AND

3818
02:36:33,680 --> 02:36:35,200
SOMETHING THAT REALLY EXCITES

3819
02:36:35,200 --> 02:36:37,360
US.  THAT THIS COLLABORATION

3820
02:36:37,360 --> 02:36:39,760
OVER LONG DISTANCES WITH THESE

3821
02:36:39,760 --> 02:36:42,000
ELECTRONIC PLATFORMS, AND

3822
02:36:42,000 --> 02:36:44,560
SHARING OF DATA, IS REALLY

3823
02:36:44,560 --> 02:36:45,560
POSSIBLE AND THEY ARE TAKING

3824
02:36:45,560 --> 02:36:53,200
ADVANTAGE OF THAT. THAT IS WHAT

3825
02:36:53,200 --> 02:36:56,800
I WILL TALK ABOUT THE PTDP HEAL

3826
02:36:56,800 --> 02:36:58,280
PAIN DEVELOPMENT THERAPEUTICS

3827
02:36:58,280 --> 02:37:00,440
DEVELOPMENT PROGRAM, THIS IS A

3828
02:37:00,440 --> 02:37:01,400
VIRTUAL PHARMA MODEL FOR

3829
02:37:01,400 --> 02:37:03,360
SUPPORTING A PROJECT. NINDS, NIH

3830
02:37:03,360 --> 02:37:07,200
THROUGH THE HEAL INITIATIVE AND

3831
02:37:07,200 --> 02:37:09,760
THIS IS A STRUCTURE WE LEARNED

3832
02:37:09,760 --> 02:37:12,960
FROM THE BLUEPRINT THERAPEUTICS

3833
02:37:12,960 --> 02:37:14,080
PROGRAM, HAS CLINICAL TRIALS

3834
02:37:14,080 --> 02:37:16,320
FROM MEDICINAL CHEMISTRY, PK AND

3835
02:37:16,320 --> 02:37:19,600
TOX STUDIES DATA MANAGEMENT,

3836
02:37:19,600 --> 02:37:22,160
MANUFACTURING AND POPULATION,

3837
02:37:22,160 --> 02:37:23,080
SUPPORT FOR CLINICAL TRIALS. SO

3838
02:37:23,080 --> 02:37:28,200
THE WAY THESE PROJECTS WORK

3839
02:37:28,200 --> 02:37:29,920
AFTER THEY ARE ACCEPTED INTO THE

3840
02:37:29,920 --> 02:37:32,120
PROGRAM THERE IS A CORE

3841
02:37:32,120 --> 02:37:33,720
CONSULTANT GROUP THAT'S

3842
02:37:33,720 --> 02:37:37,600
DEVELOPED TO SUPPORT THESE

3843
02:37:37,600 --> 02:37:39,360
PROJECTS. AND THEY DON'T HAVE TO

3844
02:37:39,360 --> 02:37:41,240
HAVE EXPERTISE FOR DOING

3845
02:37:41,240 --> 02:37:44,200
MEDICINAL CHEMISTRY OR THE

3846
02:37:44,200 --> 02:37:46,000
FORMULATION IN THEIR PARTICULAR

3847
02:37:46,000 --> 02:37:48,440
RESEARCH GROUP BUT THEY WILL

3848
02:37:48,440 --> 02:37:49,920
HAVE -- DEVELOP FOR THEM AND

3849
02:37:49,920 --> 02:37:51,520
ALSO THEY CAN TAKE ADVANTAGE OF

3850
02:37:51,520 --> 02:37:52,560
CLINICAL TRIALS IN ORDER TO GET

3851
02:37:52,560 --> 02:37:54,080
THESE DONE. SO WE HAVE A FEW

3852
02:37:54,080 --> 02:37:56,080
REALLY EXCITING BIG WINS FROM

3853
02:37:56,080 --> 02:37:59,480
THIS PROGRAM SO FAR WE HAVE ONE

3854
02:37:59,480 --> 02:38:00,520
PHASE 1 CLINICAL TRIAL COMPLETE

3855
02:38:00,520 --> 02:38:02,320
AND WE HAVE TWO LICENSING

3856
02:38:02,320 --> 02:38:04,000
AGREEMENTS WITH BIG PHARMA TO

3857
02:38:04,000 --> 02:38:06,280
HELP IN THE DEVELOPMENT OF THESE

3858
02:38:06,280 --> 02:38:07,440
PROJECTS WITH THESE GROUPS AND

3859
02:38:07,440 --> 02:38:09,720
IS CURRENTLY SEVEN PROJECTS

3860
02:38:09,720 --> 02:38:10,480
ONGOING IN THIS PARTICULAR

3861
02:38:10,480 --> 02:38:12,600
PROGRAM. THERE IS A NEW PROGRAM

3862
02:38:12,600 --> 02:38:16,480
THAT WE STARTED. THIS WAS

3863
02:38:16,480 --> 02:38:20,240
APPROVED LAST YEAR, WITH MDWG,

3864
02:38:20,240 --> 02:38:21,480
THE FUNDING ANNOUNCEMENTS WENT

3865
02:38:21,480 --> 02:38:22,880
ON THE STREET AND WE RECEIVED

3866
02:38:22,880 --> 02:38:24,440
APPLICATIONS.  THIS IS CALLED

3867
02:38:24,440 --> 02:38:26,160
REJOIN. THIS IS RESTORING JOINT

3868
02:38:26,160 --> 02:38:26,880
HEALTH AND FUNCTION TO REDUCE

3869
02:38:26,880 --> 02:38:29,360
PAIN. THE GOAL OF THIS PROGRAM

3870
02:38:29,360 --> 02:38:31,400
IS TO REALLY LOOK AT THE

3871
02:38:31,400 --> 02:38:33,600
INNOVATION OF THE DIFFERENT

3872
02:38:33,600 --> 02:38:35,200
TYPES OF ARTICULAR AN

3873
02:38:35,200 --> 02:38:37,520
PERIARTICULAR TISSUES. THAT

3874
02:38:37,520 --> 02:38:39,720
COLLECTIVELY MAKE UP THE JOINT.

3875
02:38:39,720 --> 02:38:42,800
AND ASK HOW THAT INNERVATION PAN

3876
02:38:42,800 --> 02:38:44,320
THOSE PARTICULAR TISSUES

3877
02:38:44,320 --> 02:38:46,040
CONTRIBUTE TO THE VARIOUS TYPES

3878
02:38:46,040 --> 02:38:47,400
OF ACUTE AND CHRONIC PAIN MANY

3879
02:38:47,400 --> 02:38:50,280
THE JOINT. WE ARE TALKING

3880
02:38:50,280 --> 02:38:51,800
CARTILAGE, INTRASYNOVIAL SPACE,

3881
02:38:51,800 --> 02:38:53,920
THE BONE, THE MUSCLE, THE

3882
02:38:53,920 --> 02:38:57,400
TISSUE, FROM THE MUSCLE

3883
02:38:57,400 --> 02:38:58,840
INSERTING ON TO THE BONE, ET

3884
02:38:58,840 --> 02:39:00,280
CETERA, ET CETERA. THEN OF

3885
02:39:00,280 --> 02:39:03,040
COURSE THE FASCIA THERE. SO

3886
02:39:03,040 --> 02:39:05,400
THERE ARE PARTICULAR JOINTS THAT

3887
02:39:05,400 --> 02:39:06,520
WE KNOW CONTRIBUTE TO LOTS OF

3888
02:39:06,520 --> 02:39:09,000
DIFFERENT CHRONIC PAIN

3889
02:39:09,000 --> 02:39:10,120
CONDITIONS LIKE TEMPORAL

3890
02:39:10,120 --> 02:39:11,920
MANDIBULAR JOINT AND THE KNEE,

3891
02:39:11,920 --> 02:39:13,880
THAT IS KIND OF A FOCUS INZOOID

3892
02:39:13,880 --> 02:39:17,240
THE FUNDING ANNOUNCEMENT TO HELP

3893
02:39:17,240 --> 02:39:18,800
US UNDERSTAND THOSE PARTICULAR,

3894
02:39:18,800 --> 02:39:20,680
AGAIN NEURAL INNOVATION IN THERE

3895
02:39:20,680 --> 02:39:23,920
AND HOW THAT CONTRIBUTE TO PAIN

3896
02:39:23,920 --> 02:39:26,200
AND THOSE APPLICATIONS GOING

3897
02:39:26,200 --> 02:39:31,520
THROUGH REVIEW. I'M SORRY. THE

3898
02:39:31,520 --> 02:39:33,040
NEXT PART OF TO DISCUSS IS

3899
02:39:33,040 --> 02:39:35,960
REALLY EXCITING. THE PRECISION

3900
02:39:35,960 --> 02:39:38,400
HUMAN -- EVALUATE CELLS TO GENE

3901
02:39:38,400 --> 02:39:39,640
INFORMATION THAT SPECIFY

3902
02:39:39,640 --> 02:39:41,160
INTRICACIES ORIGINS IN NATURE OF

3903
02:39:41,160 --> 02:39:42,640
HUMAN PAIN, THAT IS A MOUTHFUL

3904
02:39:42,640 --> 02:39:44,240
BUT STILL A PROGRAM THAT VERY

3905
02:39:44,240 --> 02:39:47,240
EXCITED ABOUT. THIS IS TO LOOK

3906
02:39:47,240 --> 02:39:49,400
AT HUMAN TISSUE.  FROM HUMANS

3907
02:39:49,400 --> 02:39:51,720
WITH CHRONIC PAIN. THE SOURCES

3908
02:39:51,720 --> 02:39:53,960
FOR THE TISSUES WILL BE LOCAL

3909
02:39:53,960 --> 02:39:56,160
TRANSPLANT CENTERS, CONSORTIUM

3910
02:39:56,160 --> 02:39:58,120
OF TRANSPLANT CENTERS PROVIDED

3911
02:39:58,120 --> 02:39:59,800
TO DIFFERENT GROUPS, WE HAVE THE

3912
02:39:59,800 --> 02:40:00,840
NATIONAL DISEASE RESEARCH

3913
02:40:00,840 --> 02:40:03,240
INTERCHANGE, THE NDRI NINDS

3914
02:40:03,240 --> 02:40:05,320
SUPPORTS AND NEUROBIOBANK ET

3915
02:40:05,320 --> 02:40:06,760
CETERA. COLLABORATIONS WITH

3916
02:40:06,760 --> 02:40:10,560
LOCAL SURGEONS. TO TAKE THAT

3917
02:40:10,560 --> 02:40:13,080
TISSUE FROM PATIENTS, GET VERY

3918
02:40:13,080 --> 02:40:15,840
GOOD PHENOTYPE OF THOSE TISSUES

3919
02:40:15,840 --> 02:40:19,280
OF THE PAIN DISORDER AND MAYBE

3920
02:40:19,280 --> 02:40:22,560
ADDICTION, INDIVIDUALS HAVE,

3921
02:40:22,560 --> 02:40:24,120
THEN ASK WHAT CHANGES ARE THERE

3922
02:40:24,120 --> 02:40:26,720
IN THE GENES, WHAT PROTEIN

3923
02:40:26,720 --> 02:40:28,440
EXPRESSION, ET CETERA. MAYBE THE

3924
02:40:28,440 --> 02:40:30,880
FUNCTIONAL IMAGING OR EVEN

3925
02:40:30,880 --> 02:40:31,880
ELECTROPHYSIOLOGY ON CELLS WHICH

3926
02:40:31,880 --> 02:40:33,680
WE HAVE SEEN GROUPS DO. SO YOU

3927
02:40:33,680 --> 02:40:34,800
MIGHT HAVE SEEN SOME PAPERS

3928
02:40:34,800 --> 02:40:36,880
COMING OUT IN THIS DOMAIN. BUT

3929
02:40:36,880 --> 02:40:38,560
THE BENEFIT OF THIS PARTICULAR,

3930
02:40:38,560 --> 02:40:40,920
GOING TO EMPHASIZE, NETWORK, IS

3931
02:40:40,920 --> 02:40:43,600
THAT THERE IS A COORDINATION OF

3932
02:40:43,600 --> 02:40:45,320
-- WITH DATA CENTER SO THAT THE

3933
02:40:45,320 --> 02:40:47,200
DATA HAS TO COME IN IN THE SAME

3934
02:40:47,200 --> 02:40:50,200
FORMAT AND MORE IMPORTANTLY, IT

3935
02:40:50,200 --> 02:40:51,520
HAVE TO BE STANDARDIZATION

3936
02:40:51,520 --> 02:40:54,360
WITHOUT PROCESSING THE TISSUES.

3937
02:40:54,360 --> 02:40:55,080
>> MICHAEL.

3938
02:40:55,080 --> 02:40:57,040
>> YOU CAN'T HEAR ME?

3939
02:40:57,040 --> 02:41:01,480
>> EVERYTHING IS OKAY
MICHAEL.

3940
02:41:01,480 --> 02:41:04,840
>> THE BENEFIT OF THIS IS

3941
02:41:04,840 --> 02:41:08,040
COORDINATION OF DATA PROCESSING

3942
02:41:08,040 --> 02:41:09,240
AND DATA STORING AND THE GOAL IS

3943
02:41:09,240 --> 02:41:13,160
TO MAKE ALL THIS DATA AVAILABLE

3944
02:41:13,160 --> 02:41:14,960
SO GOAL OF THIS PROGRAM IS NOT

3945
02:41:14,960 --> 02:41:15,960
PUBLICATION, THE GOAL OF THIS

3946
02:41:15,960 --> 02:41:17,720
PROGRAM IS CREATE A DATA SET

3947
02:41:17,720 --> 02:41:19,440
THAT CAN BE MINED BY THOSE DOING

3948
02:41:19,440 --> 02:41:21,400
THERAPEUTICS DEVELOPMENT STUDIES

3949
02:41:21,400 --> 02:41:23,400
AND OTHER TYPES OF PROJECTS TO

3950
02:41:23,400 --> 02:41:25,880
GET US TO UNDERSTAND HUMAN PAIN.

3951
02:41:25,880 --> 02:41:29,160
ALL HUMAN TISSUE.  NEXT SLIDE. 

3952
02:41:29,160 --> 02:41:32,080
SO THE THIS TRANSLATED

3953
02:41:32,080 --> 02:41:36,080
DISCOVERIES FOR DEVICES IS THE

3954
02:41:36,080 --> 02:41:36,880
MULTI-FACETED DEVICE PROGRAM

3955
02:41:36,880 --> 02:41:39,280
THAT WE HAVE INSIDE OF HEAL TO

3956
02:41:39,280 --> 02:41:40,840
SUPPORT CLINICAL TRIALS AS WELL

3957
02:41:40,840 --> 02:41:43,600
AS BASIC SCIENCE STUDIES TO

3958
02:41:43,600 --> 02:41:44,800
UNDERSTAND MECHANISM OF ACTION

3959
02:41:44,800 --> 02:41:47,200
OF THESE DEVICES IN ORDER TO

3960
02:41:47,200 --> 02:41:48,920
OPTIMIZE THEM FOR PEOPLE WHO ARE

3961
02:41:48,920 --> 02:41:52,200
ALREADY RECEIVING BENEFIT FROM

3962
02:41:52,200 --> 02:41:54,440
THEM ALSO HOW TO GET DEVICES

3963
02:41:54,440 --> 02:41:56,600
OPTIMIZED FOR THOSE WHO AREN'T

3964
02:41:56,600 --> 02:41:57,800
GETTING BENEFITS. WE HAVE EIGHT

3965
02:41:57,800 --> 02:42:00,000
CLINICAL TRIALS GOING AND SIX

3966
02:42:00,000 --> 02:42:02,040
DEVELOPMENTAL PROJECTS, LOOKING

3967
02:42:02,040 --> 02:42:06,120
AT FOCUS ULTRASOUND, SPINAL CORD

3968
02:42:06,120 --> 02:42:08,040
STIMULATION, TRG STIMULATION,

3969
02:42:08,040 --> 02:42:09,840
AND PERIPHERAL NERVE

3970
02:42:09,840 --> 02:42:10,360
STIMULATION, ET CETERA, ET

3971
02:42:10,360 --> 02:42:14,080
CETERA. THERE ARE -- FUNDING

3972
02:42:14,080 --> 02:42:17,320
ANNOUNCEMENT THAT IS STILL ON

3973
02:42:17,320 --> 02:42:20,920
THE STREET IS WE ARE LOOKING

3974
02:42:20,920 --> 02:42:22,360
FORWARD TO FUNDING OUR FIRST SET

3975
02:42:22,360 --> 02:42:24,560
OF PROJECTS THIS SUMMER IS THIS

3976
02:42:24,560 --> 02:42:28,640
RFA NS 22016 AND THERE WILL BE

3977
02:42:28,640 --> 02:42:30,520
NEW RECEIPT DATES HOPEFULLY

3978
02:42:30,520 --> 02:42:35,080
COMING AVAILABLE FOR THAT ONE

3979
02:42:35,080 --> 02:42:35,920
TOO. THIS PROGRAM IS SOMETHING

3980
02:42:35,920 --> 02:42:38,600
YOU WERE REALLY EXCITED WITH IN

3981
02:42:38,600 --> 02:42:40,280
OUR WORK GROUP. THIS IS THE

3982
02:42:40,280 --> 02:42:41,680
DIVERSITY BASED SUPPLEMENT,

3983
02:42:41,680 --> 02:42:43,160
THESE ARE SUPPLEMENTS TO SUPPORT

3984
02:42:43,160 --> 02:42:47,280
THE CAREER DEVELOPMENT AND

3985
02:42:47,280 --> 02:42:49,040
RESEARCH FOR APPLICANTS FROM

3986
02:42:49,040 --> 02:42:50,200
DIVERSE BACKGROUNDS INSIDE THESE

3987
02:42:50,200 --> 02:42:51,440
STUDIES THAT ARE CURRENTLY

3988
02:42:51,440 --> 02:42:53,760
FUNDED IN HEAL. NOT JUST BASIC

3989
02:42:53,760 --> 02:42:57,040
SCIENCE IN PAIN BUT OUD. YOU CAN

3990
02:42:57,040 --> 02:43:00,600
LOOK AT NUMBER OF AWARDS, 19

3991
02:43:00,600 --> 02:43:01,920
DIVERSE CANDIDATES SUPPORTED, IT

3992
02:43:01,920 --> 02:43:05,200
IS STILL OPEN AND ON THE STREET.

3993
02:43:05,200 --> 02:43:06,640
IF YOU KNOW HEAL PROGRAMS TELL

3994
02:43:06,640 --> 02:43:08,800
THEM AND THESE ARE ALL HEAL

3995
02:43:08,800 --> 02:43:11,360
PROGRAMS ON THE LIFT LIST ON

3996
02:43:11,360 --> 02:43:12,920
THIS TABLE THAT CURRENTLY HAVE

3997
02:43:12,920 --> 02:43:14,840
SUPPLEMENTS SUPPORTING THESE

3998
02:43:14,840 --> 02:43:16,600
DIVERSE CANDIDATES IN THEIR

3999
02:43:16,600 --> 02:43:17,840
PROJECTS. GEOGRAPHIC

4000
02:43:17,840 --> 02:43:18,960
DISTRIBUTION IS ON THE RIGHT. 

4001
02:43:18,960 --> 02:43:20,920
THE NEXT RECEIPT DATE IS

4002
02:43:20,920 --> 02:43:23,440
NOVEMBER 15, 2022. YOU CAN SEE

4003
02:43:23,440 --> 02:43:24,760
THERE IS A SMALL AMOUNT OF MONEY

4004
02:43:24,760 --> 02:43:26,320
GOING TO THIS BUT WE ARE

4005
02:43:26,320 --> 02:43:28,240
SUPPORTING A LOT OF DIVERSE

4006
02:43:28,240 --> 02:43:30,400
CANDIDATES WITH THIS EARLY IN

4007
02:43:30,400 --> 02:43:32,320
CAREER, 11 GRADUATE STUDENTS AND

4008
02:43:32,320 --> 02:43:32,920
EIGHT OTHER INVESTIGATORS AT

4009
02:43:32,920 --> 02:43:37,800
OTHER STAGES.  AS I MENTION AT

4010
02:43:37,800 --> 02:43:43,320
THE BEGINNING THE SBI ARE SBIR M

4011
02:43:43,320 --> 02:43:44,760
IS SUCCESSFUL AND INTERESTINGLY

4012
02:43:44,760 --> 02:43:47,720
TO THE APPLICANTS FOR THEM TO

4013
02:43:47,720 --> 02:43:50,360
TAKE ADVANTAGE OF HEAL MONEY TO

4014
02:43:50,360 --> 02:43:54,880
SUPPORT COMPANIES DEVELOPING,

4015
02:43:54,880 --> 02:43:56,320
THERAPEUTIC INTERVENTION FOR

4016
02:43:56,320 --> 02:43:59,000
PAIN CONDITIONS THAT HAVE LITTLE

4017
02:43:59,000 --> 02:44:01,760
ABUSE LIABILITY. WE HAD A TOTAL

4018
02:44:01,760 --> 02:44:03,960
OF 42 AWARDS AT THIS POINT AND

4019
02:44:03,960 --> 02:44:07,720
THAT IS DISTRIBUTED AMONG 19 NIH

4020
02:44:07,720 --> 02:44:10,440
INSTITUTES AND CENTERS. A LOT OF

4021
02:44:10,440 --> 02:44:12,400
REALLY GREAT ACCOMPLISHMENTS, WE

4022
02:44:12,400 --> 02:44:14,040
HAVE FOUR HEAL FUNDED PROJECTS

4023
02:44:14,040 --> 02:44:15,960
IDENTIFIED AND VALIDATED NEW

4024
02:44:15,960 --> 02:44:17,560
TARGETS, WE SUPPORTED VIRTUAL

4025
02:44:17,560 --> 02:44:19,920
REALITY THERAPIES, FIVE HEAL

4026
02:44:19,920 --> 02:44:21,560
PROGRAM SBIR PROGRAMS THAT

4027
02:44:21,560 --> 02:44:24,400
ADVANCE PAIN MANAGEMENT TO

4028
02:44:24,400 --> 02:44:27,200
CLINICAL STAGE AND SEVEN PATENTS

4029
02:44:27,200 --> 02:44:32,160
HERE. THESE ARE BIG WINS AND

4030
02:44:32,160 --> 02:44:35,760
EMILY CAPIRELLO DIRECTOR OF THE

4031
02:44:35,760 --> 02:44:37,840
PROGRAM IS DOING PHENOMENAL JOB

4032
02:44:37,840 --> 02:44:40,040
WITH HER TEAM THE PSPP PROGRAM

4033
02:44:40,040 --> 02:44:42,400
PRE-CLINICAL SCREENING PLATFORM

4034
02:44:42,400 --> 02:44:44,520
FOR PAIN, MISSION IS TO

4035
02:44:44,520 --> 02:44:45,480
ACCELERATE DISCOVERY AND

4036
02:44:45,480 --> 02:44:48,360
DEVELOPMENT OF NON-OPIOID

4037
02:44:48,360 --> 02:44:49,880
ADDICTIVE TREATMENT. THE

4038
02:44:49,880 --> 02:44:52,280
APPLICANTS ARE COMPANIES AND

4039
02:44:52,280 --> 02:44:57,680
ACADEMIC IN THE U.S. AND IF THE

4040
02:44:57,680 --> 02:44:59,720
INTERNATIONAL COMMUNITY THAT

4041
02:44:59,720 --> 02:45:00,480
HAVE ASSETS THAT MAY HAVE

4042
02:45:00,480 --> 02:45:04,680
DEVELOPING OTHER THERAPEUTIC

4043
02:45:04,680 --> 02:45:06,680
CONDITIONS. THEY MAY ASK THE

4044
02:45:06,680 --> 02:45:08,120
QUESTION IT IS WORTH INVESTING

4045
02:45:08,120 --> 02:45:09,760
IN TAKING ADVANTAGE OF THIS

4046
02:45:09,760 --> 02:45:11,400
ASSET FOR THE TREATING OF PAIN

4047
02:45:11,400 --> 02:45:12,720
ACUTE OR CHRONIC PAIN OR

4048
02:45:12,720 --> 02:45:16,240
DIFFERENT PAIN MODALITIES. THE

4049
02:45:16,240 --> 02:45:19,040
PSPP HAS A CONTRACT WITH A

4050
02:45:19,040 --> 02:45:23,360
COMPANIES FOR DOING PRE-CLINICAL

4051
02:45:23,360 --> 02:45:25,080
SCREENING OR TESTING IN ANIMAL

4052
02:45:25,080 --> 02:45:26,960
MODELS THEY HAVE RIGOROUS

4053
02:45:26,960 --> 02:45:30,400
CONDITIONS FOR TESTING THOSE

4054
02:45:30,400 --> 02:45:32,000
MODELS SO MAYBE REPRODUCE THE

4055
02:45:32,000 --> 02:45:33,200
DATA THEY CURRENTLY HAVE OR GET

4056
02:45:33,200 --> 02:45:34,520
DATA IN OTHER PAIN CONDITIONS OR

4057
02:45:34,520 --> 02:45:36,200
PAIN CONDITIONS THEY NEVER

4058
02:45:36,200 --> 02:45:37,720
LOOKED AT. SO THEY -- THIS IS

4059
02:45:37,720 --> 02:45:39,800
DONE IN A PRIVATE WAY AND THE

4060
02:45:39,800 --> 02:45:45,720
DATA IS ALL CONTROLLED IN THE

4061
02:45:45,720 --> 02:45:48,360
COMMUNECATION BETWEEN APPLICANT

4062
02:45:48,360 --> 02:45:51,920
AND THE NIH AND THE INTELLECTUAL

4063
02:45:51,920 --> 02:45:52,840
PROPERTY STAYS WITH THE COMPANY.

4064
02:45:52,840 --> 02:45:56,040
THEY HAVE 30 PLUS ASSETS IN THE

4065
02:45:56,040 --> 02:45:58,400
PROGRAM AND THEY HAVE MORE THAN

4066
02:45:58,400 --> 02:46:00,680
20 ASSETS CURRENTLY STILL UNDER

4067
02:46:00,680 --> 02:46:03,800
EVALUATION. THIS IS DIVERSITY OF

4068
02:46:03,800 --> 02:46:06,120
DIFFERENT TARGET CLASSES YOU SEE

4069
02:46:06,120 --> 02:46:08,720
MT. MIDDLE IN THE GRAPH THERE.

4070
02:46:08,720 --> 02:46:09,920
NINDS IS NOT MOST OF THE

4071
02:46:09,920 --> 02:46:12,160
PROGRAMS I SHOWED YOU PREVIOUSLY

4072
02:46:12,160 --> 02:46:15,560
ALL OF THEM WERE LED BY NINDS

4073
02:46:15,560 --> 02:46:18,160
PEOPLE. IN COLLABORATION WITH

4074
02:46:18,160 --> 02:46:21,160
MANY INDIVIDUALS AT NIH HEAL

4075
02:46:21,160 --> 02:46:23,800
INITIATIVE. BUT NCATS ALSO HAS A

4076
02:46:23,800 --> 02:46:26,640
BIG ROLE THE PLAY HERE IN THE

4077
02:46:26,640 --> 02:46:29,520
PRE-CLINICAL TRANSLATIONAL

4078
02:46:29,520 --> 02:46:31,120
SPACE. JUST IN THE MISSION OF

4079
02:46:31,120 --> 02:46:32,840
NCATS FOR THOSE FAMILIAR WITH

4080
02:46:32,840 --> 02:46:33,960
IT, YOU UNDERSTAND WHAT I MEAN.

4081
02:46:33,960 --> 02:46:36,520
BUT THIS IS A SLIDE OR CHEVRON

4082
02:46:36,520 --> 02:46:38,160
DIAGRAM THAT DESCRIBE IT IS MANY

4083
02:46:38,160 --> 02:46:41,040
PROGRAMS THAT NCATS HAS IN THE

4084
02:46:41,040 --> 02:46:42,200
-- THAT ARE SUPPORTED BY THE

4085
02:46:42,200 --> 02:46:43,760
HEAL INITIATIVE. LOOK DOWN AT

4086
02:46:43,760 --> 02:46:45,120
THE PURPLE HERE, DEVELOPING NEW

4087
02:46:45,120 --> 02:46:47,480
TISSUE MODELS FOR SCREEN FOR

4088
02:46:47,480 --> 02:46:50,960
PAIN OR IPSC CELLS HERE IN THE

4089
02:46:50,960 --> 02:46:53,920
GREEN AND THEN DEVELOPMENT OF

4090
02:46:53,920 --> 02:46:55,040
INVESTIGATIONAL DRUGS FOR

4091
02:46:55,040 --> 02:46:56,640
CLINICAL TESTING ET CETERA. THEY

4092
02:46:56,640 --> 02:46:58,840
HAVE 65 TOTAL PROJECTS. AND THEN

4093
02:46:58,840 --> 02:47:00,920
THEY HAVE CHALLENGE GRANTS AND

4094
02:47:00,920 --> 02:47:02,640
THINGS SUPPORTED, 22 WINNERS FOR

4095
02:47:02,640 --> 02:47:03,600
THOSE AND COLLABORATION BETWEEN

4096
02:47:03,600 --> 02:47:05,680
INTRAMURAL AND EXTRAMURAL, THEY

4097
02:47:05,680 --> 02:47:07,560
HAVE 43 ONGOING CURRENTLY

4098
02:47:07,560 --> 02:47:08,040
SUPPORTED BY THE HEAL

4099
02:47:08,040 --> 02:47:11,280
INITIATIVE. SO THEREFORE 3

4100
02:47:11,280 --> 02:47:13,560
FUNDING ANNOUNCEMENTS THAT ARE

4101
02:47:13,560 --> 02:47:15,320
STILL FOR PROGRAMS THAT ARE RUN

4102
02:47:15,320 --> 02:47:18,120
BY NCATS AT NINDS PARTICIPATES

4103
02:47:18,120 --> 02:47:19,680
IN THAT ARE STILL ON THE STREET.

4104
02:47:19,680 --> 02:47:23,080
THEY ARE EMERGENCY REWARDS FOR K

4105
02:47:23,080 --> 02:47:25,160
18, THAT IS TO HAVE BASIC

4106
02:47:25,160 --> 02:47:27,760
SCIENCE RESEARCHER, SPEND SOME

4107
02:47:27,760 --> 02:47:31,120
TIME IN TRANSLATIONAL LAB EITHER

4108
02:47:31,120 --> 02:47:32,720
ACADEMIA OR INDUSTRY TO LEARN

4109
02:47:32,720 --> 02:47:34,840
TRANSLATIONAL RESEARCH. WE HAVE

4110
02:47:34,840 --> 02:47:37,480
THE DP 2 AWARDS, INNOVATOR

4111
02:47:37,480 --> 02:47:42,240
AWARDS SIMILAR TO THE NIH OD DP

4112
02:47:42,240 --> 02:47:43,880
2 INVEIGH FOR AWARDS, FOCUS OF

4113
02:47:43,880 --> 02:47:45,320
RESEARCH HAS TO BE AROUND

4114
02:47:45,320 --> 02:47:49,480
SCIENCE. THEN WE ALSO HAVE THE

4115
02:47:49,480 --> 02:47:51,720
R21 FOR VALIDATING OR

4116
02:47:51,720 --> 02:47:53,120
IDENTIFYING TARGETS IN THE

4117
02:47:53,120 --> 02:47:54,400
DRUGGABLE GENOME WHICH IS A

4118
02:47:54,400 --> 02:47:56,520
DATABASE OF UNIDENTIFIED GENES

4119
02:47:56,520 --> 02:48:01,880
AND PROTEINS AND WHAT THEY DO

4120
02:48:01,880 --> 02:48:04,200
BUT TO UNDERSTAND FROM RESEARCH

4121
02:48:04,200 --> 02:48:04,800
STANDPOINT WHETHER OR NOT THEY

4122
02:48:04,800 --> 02:48:06,360
CAN BE USED AS TARGETS FOR

4123
02:48:06,360 --> 02:48:12,920
TREATING PAIN.  SO THERE ARE TWO

4124
02:48:12,920 --> 02:48:15,520
PARTICULAR COLLABORATION BETWEEN

4125
02:48:15,520 --> 02:48:17,720
HEAL AND NIH BLUEPRINT

4126
02:48:17,720 --> 02:48:18,560
NEUROTHERAPEUTIC PROGRAM WE

4127
02:48:18,560 --> 02:48:21,480
FUNDED ASPECT OF THESE PROJECTS

4128
02:48:21,480 --> 02:48:25,680
WHICH HAVE HAD BIG WINS.  ONE ON

4129
02:48:25,680 --> 02:48:27,560
THE RIGHT IS COMPLETED PHASE 1A

4130
02:48:27,560 --> 02:48:33,040
CLINICAL TRIAL FOR THEIR EC 502C

4131
02:48:33,040 --> 02:48:37,760
WHICH IS SEH INHIBITOR HYPOXY

4132
02:48:37,760 --> 02:48:40,600
HYDROXYLASE INHIBITOR, WHICH IS

4133
02:48:40,600 --> 02:48:41,880
NOVEL COMPOUND FOR WHICH HAS

4134
02:48:41,880 --> 02:48:44,840
POTENTIAL IN TREATING PAIN AND

4135
02:48:44,840 --> 02:48:48,200
THEN WE HAVE THERAPEUTICS AS

4136
02:48:48,200 --> 02:48:50,040
PARTNER, A LARGE PARTNERSHIP

4137
02:48:50,040 --> 02:48:52,200
WITH SIGNIFICANT PHARMACEUTICAL

4138
02:48:52,200 --> 02:48:57,160
COMPANY TO DEVELOP THEIR NAV 1.7

4139
02:48:57,160 --> 02:48:58,160
INHIBITORS, THEY SITE ONE MOST

4140
02:48:58,160 --> 02:49:01,240
OF THE OTHER NAV, 1.7 INHIBITORS

4141
02:49:01,240 --> 02:49:02,680
LOOKING AT OTHER BINDING SITES

4142
02:49:02,680 --> 02:49:04,040
SO THEY THINK THEY HAVE A

4143
02:49:04,040 --> 02:49:06,280
POTENTIAL HERE TO BE SUCCESSFUL

4144
02:49:06,280 --> 02:49:08,240
FOR THAT. THIS IS PROJECT

4145
02:49:08,240 --> 02:49:12,040
CO-FUNDED BY HEAL AND BPN

4146
02:49:12,040 --> 02:49:14,320
PROGRAM. THIS SUMMARY SLIDE WILL

4147
02:49:14,320 --> 02:49:16,520
GIVE YOU A FEEL FOR THE NUMBER

4148
02:49:16,520 --> 02:49:17,680
ON THE RIGHT PAIN CONDITIONS

4149
02:49:17,680 --> 02:49:19,760
THAT ARE BEING SUPPORTED

4150
02:49:19,760 --> 02:49:21,680
CURRENTLY BY HEAL FUNDED

4151
02:49:21,680 --> 02:49:24,200
PROJECTS. OR THE TARGETS THAT

4152
02:49:24,200 --> 02:49:25,320
THESE PARTICULAR PROJECTS ARE

4153
02:49:25,320 --> 02:49:26,920
LOOKING AT EITHER IN THE CASE OF

4154
02:49:26,920 --> 02:49:28,280
RECEPTORS OR CHANNELS OR

4155
02:49:28,280 --> 02:49:29,520
PARTICULAR CELL TYPES OR PAIN

4156
02:49:29,520 --> 02:49:32,360
PATHWAYS.  THERE ARE 34 AWARDS

4157
02:49:32,360 --> 02:49:35,560
FOR TARGET DISCOVERY AND

4158
02:49:35,560 --> 02:49:36,960
VALIDATION, 14 DEVICE PROGRAMS

4159
02:49:36,960 --> 02:49:39,720
AND 16 THERAPEUTICS PROGRAMS.

4160
02:49:39,720 --> 02:49:41,680
EITHER WITH SMALL MOLECULE AND

4161
02:49:41,680 --> 02:49:44,040
BIOLOGICS CURRENTLY BEING FUNDED

4162
02:49:44,040 --> 02:49:49,040
BY THESE HEAL PROGRAMS. SO

4163
02:49:49,040 --> 02:49:49,880
MISPOINT CHANGE GEAR AND TALK

4164
02:49:49,880 --> 02:49:55,880
THREE CONCEPTS. A AND FOR FY 23

4165
02:49:55,880 --> 02:49:59,080
WE WOULD LIKE TO ADD TO OUR

4166
02:49:59,080 --> 02:50:00,920
PORTFOLIO OF FUNDING

4167
02:50:00,920 --> 02:50:03,720
OPPORTUNITIES INSIDE OF HEAL.

4168
02:50:03,720 --> 02:50:06,760
THE FIRST ONE IS THE CONCEPT OF

4169
02:50:06,760 --> 02:50:08,560
INTEGRATED BASIC AND CLINICAL

4170
02:50:08,560 --> 02:50:10,680
RESEARCH IN PAIN SO THIS IS A --

4171
02:50:10,680 --> 02:50:12,480
WE ARE GOING TO USE PLAN HERE IS

4172
02:50:12,480 --> 02:50:14,640
TO USE AN RO1 AND THERE WILL BE

4173
02:50:14,640 --> 02:50:17,000
A COLLABORATION AS WAS MENTIONED

4174
02:50:17,000 --> 02:50:19,120
EARLIER BETWEEN THIS NEED FOR

4175
02:50:19,120 --> 02:50:20,760
COLLABORATION BETWEEN A

4176
02:50:20,760 --> 02:50:22,920
CLINICIAN AND A BASIC SCIENTIST

4177
02:50:22,920 --> 02:50:25,120
IN ORDER TO UNDERSTAND THE

4178
02:50:25,120 --> 02:50:26,840
UNDERLYING BIOLOGY AND GET

4179
02:50:26,840 --> 02:50:29,200
MECHANISTIC UNDERSTANDING OF THE

4180
02:50:29,200 --> 02:50:30,640
PAINFUL CONDITION. AND THAT IS

4181
02:50:30,640 --> 02:50:32,960
BEST DONE WITH THIS

4182
02:50:32,960 --> 02:50:34,320
COLLABORATION BETWEEN BASIC

4183
02:50:34,320 --> 02:50:36,320
SCIENCE AN CLINICIAN. THE REASON

4184
02:50:36,320 --> 02:50:40,960
FOR THE NEED FOR THIS CONCEPT IS

4185
02:50:40,960 --> 02:50:43,480
BECAUSE APPLICATIONS IN OUR

4186
02:50:43,480 --> 02:50:45,680
EXPERIENCE AS PROGRAM STAFF THAT

4187
02:50:45,680 --> 02:50:47,240
CONTAIN BOTH CLINICAL AND BASIC

4188
02:50:47,240 --> 02:50:48,920
SCIENCE COMPONENT HAVE A

4189
02:50:48,920 --> 02:50:51,120
DIFFICULTY IN REVIEW BECAUSE OF

4190
02:50:51,120 --> 02:50:52,920
THE FOCUS OF THE STUDY SECTION

4191
02:50:52,920 --> 02:50:54,560
IS USUALLY EITHER BASIC SCIENCE

4192
02:50:54,560 --> 02:50:57,800
OR CLINICAL. THESE PARTICULAR

4193
02:50:57,800 --> 02:51:00,600
APPLICATIONS WILL HAVE THE TEAM

4194
02:51:00,600 --> 02:51:01,520
BASED REVIEW UNDERSTANDING THAT

4195
02:51:01,520 --> 02:51:03,560
THAT IS A GOAL OF THE PROGRAM

4196
02:51:03,560 --> 02:51:05,760
AND WE ARE HOPING FOCUS PROGRAM

4197
02:51:05,760 --> 02:51:09,080
LIKE THIS IS MORE SUCCESSFUL

4198
02:51:09,080 --> 02:51:10,000
THAN THE STANDARD STUDY

4199
02:51:10,000 --> 02:51:17,800
SECTIONS.  THIS NEXT CONCEPT IS

4200
02:51:17,800 --> 02:51:21,960
AROUND DEVELOPMENT OF ANIMAL

4201
02:51:21,960 --> 02:51:24,360
MODELS WITH NON-RODENT SPECIES

4202
02:51:24,360 --> 02:51:26,080
FOR THE TREATMENT OF PAIN. SO

4203
02:51:26,080 --> 02:51:27,680
THE GOAL HERE IS TO DEVELOP

4204
02:51:27,680 --> 02:51:30,840
VALIDATE THOSE MODELS AROUND

4205
02:51:30,840 --> 02:51:33,160
PARTICULAR NATIONALLY OCCURRING

4206
02:51:33,160 --> 02:51:34,200
DISEASE NATURALLY OCCURRING

4207
02:51:34,200 --> 02:51:36,160
DISEASE IN THOSE ANIMAL

4208
02:51:36,160 --> 02:51:38,120
POPULATIONS IN ORDER THE USE FOR

4209
02:51:38,120 --> 02:51:40,040
BIOMARKER OR BASIC SCIENCE

4210
02:51:40,040 --> 02:51:43,800
STUDIES IN ORDER TO GET A BETTER

4211
02:51:43,800 --> 02:51:45,720
FUNDAMENTAL UNDERSTANDING OF

4212
02:51:45,720 --> 02:51:46,360
PATHOPHYSIOLOGY OF THAT PAIN

4213
02:51:46,360 --> 02:51:49,360
CONDITION.  THAT IS A SECOND

4214
02:51:49,360 --> 02:51:52,080
CONCEPT. THE THIRD ONE IS TO

4215
02:51:52,080 --> 02:51:55,840
SUPPLEMENT TO ONGOING HEAL

4216
02:51:55,840 --> 02:52:00,760
PROJECTS TO EMBED AN EXPERT IN

4217
02:52:00,760 --> 02:52:03,360
BUSINESS DEVELOPMENT ALONG WITH

4218
02:52:03,360 --> 02:52:05,680
THESE TEAMS TO GET THEM TO TAKE

4219
02:52:05,680 --> 02:52:07,120
THEIR IDEAS FROM THE BASIC

4220
02:52:07,120 --> 02:52:09,680
SCIENCE STAGE OR THE EARLY

4221
02:52:09,680 --> 02:52:10,480
TRANSLATIONAL PHASE TO

4222
02:52:10,480 --> 02:52:11,480
UNDERSTAND WHAT IT MEANS TO

4223
02:52:11,480 --> 02:52:12,840
START A BUSINESS AND REALLY

4224
02:52:12,840 --> 02:52:14,600
DEVELOP A THERAPEUTIC SO THAT IT

4225
02:52:14,600 --> 02:52:17,720
CAN GET INTO THE HANDS OF THE BY

4226
02:52:17,720 --> 02:52:19,600
IN ADDITION AND THEN EVENTUALLY

4227
02:52:19,600 --> 02:52:21,160
THE PATIENTS THEMSELVES SO WE

4228
02:52:21,160 --> 02:52:23,600
UNDERSTAND THAT THIS TRANSITION

4229
02:52:23,600 --> 02:52:25,040
FROM THE SCIENTIFIC ASPECT OF

4230
02:52:25,040 --> 02:52:26,920
THE PROJECT TO BUSINESS ASPECT

4231
02:52:26,920 --> 02:52:29,640
OF THE PROJECT COULD BE HARD.

4232
02:52:29,640 --> 02:52:31,960
AND THEIR EXPERIENCE AT NIH WITH

4233
02:52:31,960 --> 02:52:33,000
SIMILAR PROGRAMS THAT HAVE BEEN

4234
02:52:33,000 --> 02:52:34,120
SUCCESSFUL SO WE WANT TO TAKE

4235
02:52:34,120 --> 02:52:36,240
ADVANTAGE OF THAT IN THE HEAL

4236
02:52:36,240 --> 02:52:38,240
SPACE BECAUSE OF THE IDEA OF --

4237
02:52:38,240 --> 02:52:40,360
AND OVERALL GOAL OF HEAL IS TO

4238
02:52:40,360 --> 02:52:42,760
ENHANCE PAIN MANAGEMENT WE KNOW

4239
02:52:42,760 --> 02:52:43,480
THAT CAN'T HAPPEN WITHOUT

4240
02:52:43,480 --> 02:52:44,920
GETTING NEW TREATMENT AND

4241
02:52:44,920 --> 02:52:46,280
OPPORTUNITIES IN THE HANDS OF

4242
02:52:46,280 --> 02:52:48,000
PHYSICIAN AND PATIENTS TO TREAT

4243
02:52:48,000 --> 02:52:49,880
THEIR PAIN. THIS LAST SLIDE IS

4244
02:52:49,880 --> 02:52:52,520
JUST TO SHOW YOU THE TEAM OF

4245
02:52:52,520 --> 02:52:54,080
PEOPLE ON THE PAIN HEAL PAIN

4246
02:52:54,080 --> 02:52:55,960
PRE-CLINICAL TRANSLATIONAL TEAM

4247
02:52:55,960 --> 02:53:00,880
THAT CONTRIBUTED TO THESE MANY

4248
02:53:00,880 --> 02:53:01,800
DIFFERENT FUNDING OPPORTUNITIES

4249
02:53:01,800 --> 02:53:03,040
AND CONTRACT PROGRAMS ET CETERA,

4250
02:53:03,040 --> 02:53:04,200
REALLY A BIG TEAM AN

4251
02:53:04,200 --> 02:53:04,800
COLLABORATIVE. THANK YOU SO

4252
02:53:04,800 --> 02:53:07,200
MUCH.

4253
02:53:07,200 --> 02:53:08,960
>> VERY IMPRESSIVE, YOU
MANAGED

4254
02:53:08,960 --> 02:53:11,600
TO GIVE AN HOUR LONG TALK IN

4255
02:53:11,600 --> 02:53:12,640
ABOUT 25 MINUTES. SO WE ARE

4256
02:53:12,640 --> 02:53:14,360
GOING TO DO THIS IN REVERSE

4257
02:53:14,360 --> 02:53:16,560
ORDER. MICHAEL PROPOSED THE

4258
02:53:16,560 --> 02:53:17,560
CONCEPTS THREE INITIATIVES

4259
02:53:17,560 --> 02:53:19,360
FORMALLY WE DON'T NEED TO

4260
02:53:19,360 --> 02:53:21,560
ACTUALLY VOTE ON HEAL INITIATIVE

4261
02:53:21,560 --> 02:53:24,120
CONCEPTS TO COUNCIL BUT IF THERE

4262
02:53:24,120 --> 02:53:25,920
ARE ANY SIGNIFICANT COMMENTS YOU

4263
02:53:25,920 --> 02:53:28,360
WANT TO MAKE ABOUT ANY OF THOSE

4264
02:53:28,360 --> 02:53:29,600
OR QUESTIONS ABOUT ANY OF THOSE

4265
02:53:29,600 --> 02:53:31,200
THREE INITIATIVES NOW WOULD BE A

4266
02:53:31,200 --> 02:53:36,120
GOOD TIME TO DO THAT.

4267
02:53:36,120 --> 02:53:37,920
>> WE ACTUALLY BEFORE THE

4268
02:53:37,920 --> 02:53:39,200
MEETING GOT SOME QUESTIONS, I

4269
02:53:39,200 --> 02:53:41,040
GOT SOME QUESTIONS ABOUT THE USE

4270
02:53:41,040 --> 02:53:47,120
OF THE RM 1 MECHANISM WHICH IS A

4271
02:53:47,120 --> 02:53:48,920
NEW COLLABORATIVE MECHANISM THAT

4272
02:53:48,920 --> 02:53:51,360
WE DEVELOPED AND HEAL SEEMS LIKE

4273
02:53:51,360 --> 02:53:53,040
REALLY EXCELLENT PLACE TO PILOT

4274
02:53:53,040 --> 02:53:54,720
THOSE KINDS OF COLLABORATIONS.

4275
02:53:54,720 --> 02:53:56,760
MECHANISM IS ALREADY BEEN USED,

4276
02:53:56,760 --> 02:53:58,800
VERY SIMILAR MECHANISM BY NIGMS

4277
02:53:58,800 --> 02:54:01,160
AND IS ACTUALLY BEEN I WOULD SAY

4278
02:54:01,160 --> 02:54:04,600
MUCH MORE SUCCESSFUL STANDARD

4279
02:54:04,600 --> 02:54:06,280
PROGRAM PROJECT MULTI-PI RO1.

4280
02:54:06,280 --> 02:54:08,000
THAT'S KIND OF A PRELIMINARY

4281
02:54:08,000 --> 02:54:10,560
RESULT. ARE THERE ANYTHING --

4282
02:54:10,560 --> 02:54:13,200
ANYTHING -- ANY OTHER QUESTIONS

4283
02:54:13,200 --> 02:54:14,520
ABOUT THESE INITIATIVE CONCEPTS?

4284
02:54:14,520 --> 02:54:21,040
IF IF NOT, GREAT, NOW I CAN SEE

4285
02:54:21,040 --> 02:54:22,760
EVERYBODY. IF NOT I SEE KEN HAS

4286
02:54:22,760 --> 02:54:25,720
-- IF NOT JUST SOMETHING FOR TWO

4287
02:54:25,720 --> 02:54:30,480
OR THREE GENERAL QUESTIONS. KE .

4288
02:54:30,480 --> 02:54:32,960
>> MICHAEL, LINDA, THIS IS

4289
02:54:32,960 --> 02:54:35,680
TREMENDOUS, I WASN'T SURE IF I'M

4290
02:54:35,680 --> 02:54:40,680
IN A PHARMA COMPANY

4291
02:54:40,680 --> 02:54:43,920
PRESENTATION. YOU GUYS ARE GOING

4292
02:54:43,920 --> 02:54:46,680
TO STOP GETTING PHARMA

4293
02:54:46,680 --> 02:54:48,200
COMPETITION SOON. I LOVE THE

4294
02:54:48,200 --> 02:54:51,080
THREE POLES FOR FISCAL YEAR 23.

4295
02:54:51,080 --> 02:54:53,480
PARTICULARLY THE BUSINESS SIDE.

4296
02:54:53,480 --> 02:54:55,880
I SPENT FOUR AND A HALF YEARS IN

4297
02:54:55,880 --> 02:54:57,240
THE EXTERNAL INNOVATION SPACE

4298
02:54:57,240 --> 02:54:59,920
WHICH IS BRIDGING DUE DILIGENCE

4299
02:54:59,920 --> 02:55:01,440
SPACE WHERE YOU BRINGING THE

4300
02:55:01,440 --> 02:55:02,640
SCIENCE BUT YOU ARE WORKING WITH

4301
02:55:02,640 --> 02:55:07,200
THE BUSINESS DEVELOPMENT PEOPLE,

4302
02:55:07,200 --> 02:55:08,720
AND THE KINDS OF THINGS YOU NEED

4303
02:55:08,720 --> 02:55:10,360
TO THINK ABOUT THERE, THE

4304
02:55:10,360 --> 02:55:11,360
BUSINESS ACUMEN YOU NEED TO

4305
02:55:11,360 --> 02:55:12,640
COMBINE WITH THE SCIENCE IN

4306
02:55:12,640 --> 02:55:17,320
ORDER TO MAKE SOMETHING FLY IS

4307
02:55:17,320 --> 02:55:18,720
COMPLETELY DIFFERENT SKILL SET.

4308
02:55:18,720 --> 02:55:22,000
SO I LOVE IT. THAT SUMS UP

4309
02:55:22,000 --> 02:55:23,760
TREMENDOUS PROGRAM GOING --

4310
02:55:23,760 --> 02:55:25,280
PROGRAMS HERE IN HEAL, BOTH

4311
02:55:25,280 --> 02:55:28,680
LINDA AND MICHAEL. THANK YOU. 

4312
02:55:28,680 --> 02:55:29,120
EXCELLENT.

4313
02:55:29,120 --> 02:55:30,880
>> BY WAY I CAN SHORTEN
THE NEXT

4314
02:55:30,880 --> 02:55:32,400
SECTION A LITTLE BIT SO I THINK

4315
02:55:32,400 --> 02:55:33,760
I CAN MAKE UP A LITTLE BIT OF

4316
02:55:33,760 --> 02:55:36,200
TIME. HEAL IS IMPORTANT. SO IF

4317
02:55:36,200 --> 02:55:38,480
YOU HAVE -- DAVID.

4318
02:55:38,480 --> 02:55:42,240
>> WONDERFUL WORK VERY
EXCITING,

4319
02:55:42,240 --> 02:55:44,160
WHAT SORT OF NON-RODENT MODELS

4320
02:55:44,160 --> 02:55:46,400
ARE BEING CONSIDERED AND HOW

4321
02:55:46,400 --> 02:55:48,560
WILL ONE VET WHICH MODELS ARE

4322
02:55:48,560 --> 02:55:51,160
CHOSEN AMONG THE MANY OPTIONS?

4323
02:55:51,160 --> 02:55:53,280
>> DAVID, THAT IS AN
EXCELLENT

4324
02:55:53,280 --> 02:55:56,400
QUESTION. SO THIS IS A CONCEPT

4325
02:55:56,400 --> 02:55:59,600
FOR CLEARANCE WE BRINGING BEFORE

4326
02:55:59,600 --> 02:56:01,160
COUNCIL. INSIDE FUNDING

4327
02:56:01,160 --> 02:56:05,360
ANNOUNCEMENT WE DON'T ANTICIPATE

4328
02:56:05,360 --> 02:56:10,240
SAYING WE EXPECT MODEL X Y OR Z.

4329
02:56:10,240 --> 02:56:12,600
EXCEPT TO SAY NON-RODENT

4330
02:56:12,600 --> 02:56:17,840
SPECIES. WITH THAT SAID THERE

4331
02:56:17,840 --> 02:56:19,200
ARE CONSIDERATIONS THAT ARE

4332
02:56:19,200 --> 02:56:20,560
GOING TO NATURALLY COME OUT OF

4333
02:56:20,560 --> 02:56:22,400
THE PROJECT IF THERE IS AN

4334
02:56:22,400 --> 02:56:24,280
EMPHASIS ON NATURALLY OCCURRING

4335
02:56:24,280 --> 02:56:29,040
PAIN DISEASE INSIDE THE ANIMALS 

4336
02:56:29,040 --> 02:56:31,000
WE KNOW THERE ARE GROUPS USING

4337
02:56:31,000 --> 02:56:34,280
LARGE ANIMALS SUCH AS SWINE AND

4338
02:56:34,280 --> 02:56:36,640
THERE ARE INDIVIDUALS USING

4339
02:56:36,640 --> 02:56:39,600
COMPANION SPECIES SUCH AS DOGS

4340
02:56:39,600 --> 02:56:41,440
AND CATS IN NATURALLY OCCURRING

4341
02:56:41,440 --> 02:56:43,120
DISORDERS PAIN DISORDERS IN

4342
02:56:43,120 --> 02:56:45,880
THEM. WE IMAGINE THOSE GROUPS

4343
02:56:45,880 --> 02:56:48,320
WILL TAKE ADVANTAGE OF THIS

4344
02:56:48,320 --> 02:56:50,360
POTENTIAL FUNDING OPPORTUNITY.

4345
02:56:50,360 --> 02:56:52,360
>> IT WAS STUDY IN MY

4346
02:56:52,360 --> 02:56:54,200
NEIGHBORHOOD, WE HAD A LOT OF

4347
02:56:54,200 --> 02:56:55,840
OLD DOGS WITH CHRONIC HIP PAIN.

4348
02:56:55,840 --> 02:56:58,200
>> THERE YOU GO. NATURALLY

4349
02:56:58,200 --> 02:57:00,920
OCCURRING.

4350
02:57:00,920 --> 02:57:05,000
>> CHRIS.

4351
02:57:05,000 --> 02:57:07,080
>> SORRY HIT THE WRONG
BUTTON.

4352
02:57:07,080 --> 02:57:09,280
CERTAINLY SUPPORTIVE OF ALL THE

4353
02:57:09,280 --> 02:57:10,880
CONCEPTS THAT HAVE BEEN

4354
02:57:10,880 --> 02:57:15,800
DISCUSSED AT HEAL AND VETTED AND

4355
02:57:15,800 --> 02:57:17,480
MDWG WE ARE SUPPORTIVE OF THESE

4356
02:57:17,480 --> 02:57:19,960
MOVING FORWARD.  I PARTICULARLY

4357
02:57:19,960 --> 02:57:23,160
LIKE THE RO1 PROPOSALS, IN THE

4358
02:57:23,160 --> 02:57:25,640
BACK OF MY MIND SOMETHING SAYS

4359
02:57:25,640 --> 02:57:29,600
TO ME DO WE HAVE ENOUGH MATURE

4360
02:57:29,600 --> 02:57:31,040
PAIN RESEARCH GROUPS THAT HAVE

4361
02:57:31,040 --> 02:57:33,720
THAT EXPERTISE IN HOUSE. THAT

4362
02:57:33,720 --> 02:57:35,640
WILL BE ABLE TO SUBMIT

4363
02:57:35,640 --> 02:57:37,240
COMPETITIVE APPLICATIONS.

4364
02:57:37,240 --> 02:57:38,720
WONDERING IF YOU ARE CONCERNED

4365
02:57:38,720 --> 02:57:40,760
ABOUT THAT AND THEN MY SECOND

4366
02:57:40,760 --> 02:57:41,720
QUESTION WOULD BE IF WE DON'T

4367
02:57:41,720 --> 02:57:44,080
GET THE TYPE OF APPLICATIONS WE

4368
02:57:44,080 --> 02:57:45,680
ARE LOOKING FOR THERE, IS IT

4369
02:57:45,680 --> 02:57:48,560
POSSIBLE THAT HEAL WILL CONSIDER

4370
02:57:48,560 --> 02:57:50,920
ANOTHER FUNDING MECHANISM THAT'S

4371
02:57:50,920 --> 02:57:52,480
MORE COLLABORATIVE WITH NIH

4372
02:57:52,480 --> 02:57:54,720
WHERE YOU ACTUALLY PUT THE TEAMS

4373
02:57:54,720 --> 02:57:56,920
TOGETHER BRING PEOPLE IN FROM

4374
02:57:56,920 --> 02:57:57,680
DIFFERENT UNIVERSITIES WITH

4375
02:57:57,680 --> 02:58:00,400
DIFFERENT EXPERTISE AND PUT

4376
02:58:00,400 --> 02:58:03,640
TEAMS TOGETHER LIKE BROADER

4377
02:58:03,640 --> 02:58:05,360
INITIATIVES WITHIN BRAIN FOR

4378
02:58:05,360 --> 02:58:06,240
EXAMPLE.

4379
02:58:06,240 --> 02:58:09,040
>> CHRIS, THAT IS A
PERCEPTIVE

4380
02:58:09,040 --> 02:58:11,440
QUESTION. YOU REALLY HAVE A VERY

4381
02:58:11,440 --> 02:58:12,640
GOOD UNDERSTAND OF THE PAIN

4382
02:58:12,640 --> 02:58:14,280
FIELD. WE THINK THERE ARE

4383
02:58:14,280 --> 02:58:16,120
POTENTIAL FOR AN INITIAL STAGE

4384
02:58:16,120 --> 02:58:17,760
OF APPLICATIONS AND

4385
02:58:17,760 --> 02:58:19,520
COLLABORATIONS THAT ARE ALREADY

4386
02:58:19,520 --> 02:58:22,320
NASCENT OR ALREADY ONGOING. SO

4387
02:58:22,320 --> 02:58:24,000
WE EXPECT PEOPLE TAKING

4388
02:58:24,000 --> 02:58:25,600
ADVANTAGE OF US, OUR GOAL IS

4389
02:58:25,600 --> 02:58:27,040
MULTIPLE RECEIPT DATES AND HAVE

4390
02:58:27,040 --> 02:58:28,840
THIS BE ONGOING PROGRAM AND

4391
02:58:28,840 --> 02:58:31,280
INSPIRE NEW COLLABORATIONS. IT

4392
02:58:31,280 --> 02:58:33,720
WOULD BE BEST FOR THOSE TO

4393
02:58:33,720 --> 02:58:35,280
ORGANICALLY HAPPEN BUT WE

4394
02:58:35,280 --> 02:58:36,920
UNDERSTAND THAT AS PROGRAM

4395
02:58:36,920 --> 02:58:40,760
DIRECTORS AND PROGRAM STAFF AT

4396
02:58:40,760 --> 02:58:44,520
NIH IT IS HELPFUL FOR US TO

4397
02:58:44,520 --> 02:58:45,680
STAND BEFORE INDIVIDUALS MAYBE

4398
02:58:45,680 --> 02:58:48,520
NOT ZOOM MEETINGS BUT

4399
02:58:48,520 --> 02:58:50,000
CONFERENCES, AND EXPLAIN

4400
02:58:50,000 --> 02:58:52,960
COLLABORATIONS AND HEN TALK TO

4401
02:58:52,960 --> 02:58:57,680
AT THE UASP OR CONFERENCE, ET

4402
02:58:57,680 --> 02:58:59,480
CETERA AND ENCOURAGE THOSE

4403
02:58:59,480 --> 02:59:00,920
CLINICS TO REACH OUT TO BASIC

4404
02:59:00,920 --> 02:59:02,360
SCIENCE COLLEAGUES OR BASIC

4405
02:59:02,360 --> 02:59:04,560
SCIENCE COLLEAGUES TO REACH TOUT

4406
02:59:04,560 --> 02:59:05,760
CLINICIANS, IN ORDER TO BUILD

4407
02:59:05,760 --> 02:59:07,880
THESE COLLABORATIONS. SOME WAY

4408
02:59:07,880 --> 02:59:09,400
NIH HAS TO TEACH THEM HOW TO DO

4409
02:59:09,400 --> 02:59:10,600
IT, SOME THEY ALREADY KNOW HOW

4410
02:59:10,600 --> 02:59:12,000
TO DO IT, THEY NEED A MECHANISM

4411
02:59:12,000 --> 02:59:13,600
TO FUND IT SO I GUESS THAT IS A

4412
02:59:13,600 --> 02:59:19,000
SUMMARY OF MY ANSWER.

4413
02:59:19,000 --> 02:59:21,360
>> ALLAN.

4414
02:59:21,360 --> 02:59:23,240
>> I HAVE WRITTEN TO YOU
ABOUT

4415
02:59:23,240 --> 02:59:27,760
THIS, AND DECIDES WORTH JUST

4416
02:59:27,760 --> 02:59:29,600
MENTIONING, THE CONCEPT TOO I

4417
02:59:29,600 --> 02:59:31,960
CERTAINLY AM IN FAVOR OF IT,

4418
02:59:31,960 --> 02:59:33,400
BRINGING DIFFERENT STRENGTHS AND

4419
02:59:33,400 --> 02:59:35,120
TALENTS AND TECHNOLOGIES

4420
02:59:35,120 --> 02:59:36,800
TOGETHER WITH CLINICAL BASIC

4421
02:59:36,800 --> 02:59:39,000
SCIENCE. BUT THOSE OFTEN DON'T

4422
02:59:39,000 --> 02:59:40,920
EXIST AT ONE CAMPUS. AND

4423
02:59:40,920 --> 02:59:45,480
CERTAINLY NOT IN ONE LAB.  I'M

4424
02:59:45,480 --> 02:59:49,600
NOT SURE TO WHAT EXTENT IS IT

4425
02:59:49,600 --> 02:59:50,960
REASONABLE TO BRING IN THE

4426
02:59:50,960 --> 02:59:53,800
TALENT ACROSS THE COUNTRY FOR

4427
02:59:53,800 --> 02:59:55,120
THAT MATTER IN ANOTHER COUNTRY

4428
02:59:55,120 --> 02:59:58,400
WHERE SOMEONE HAS A PARTICULAR

4429
02:59:58,400 --> 02:59:59,160
STRENGTH WHATEVER IT IS THAT

4430
02:59:59,160 --> 03:00:01,560
WOULD BE EXACTLY APPROPRIATE FOR

4431
03:00:01,560 --> 03:00:03,080
THIS PARTICULAR APPROACH, THAT

4432
03:00:03,080 --> 03:00:06,080
DOESN'T EXIST AT UCSF FOR

4433
03:00:06,080 --> 03:00:06,400
EXAMPLE.

4434
03:00:06,400 --> 03:00:09,640
>> I THINK AGAIN GREAT
QUESTION,

4435
03:00:09,640 --> 03:00:11,040
WE TRIED TO ADDRESS THAT WITH

4436
03:00:11,040 --> 03:00:13,840
SOME OF OUR OTHER PROPOSALS AND

4437
03:00:13,840 --> 03:00:16,120
INITIATIVES INSIDE OF HEAL. FOR

4438
03:00:16,120 --> 03:00:18,800
INSTANCE, THE PLANNING STUDIES,

4439
03:00:18,800 --> 03:00:22,000
AND THE U 19 FOR THAT INITIAL

4440
03:00:22,000 --> 03:00:23,040
THERAPEUTICS DEVELOPMENT WE

4441
03:00:23,040 --> 03:00:24,800
INSIDE THE FUNDING APPLICATION

4442
03:00:24,800 --> 03:00:27,280
AND IN OUR WEBINARS HAVE SAID WE

4443
03:00:27,280 --> 03:00:29,440
DON'T EXPECT THE EXPERTISE TO BE

4444
03:00:29,440 --> 03:00:30,760
AT ONE INSTITUTION. WE EXPECT

4445
03:00:30,760 --> 03:00:33,080
THERE TO BE COLLABORATION ACROSS

4446
03:00:33,080 --> 03:00:34,920
INSTITUTIONS AND EVEN

4447
03:00:34,920 --> 03:00:37,480
INTERNATIONALLY. WE HAVE TWO

4448
03:00:37,480 --> 03:00:38,680
INTERNATIONAL COLLABORATIONS

4449
03:00:38,680 --> 03:00:40,440
CURRENTLY HAPPENING INSIDE THOSE

4450
03:00:40,440 --> 03:00:42,360
PROGRAMS AND AS I SHOWED YOU IN

4451
03:00:42,360 --> 03:00:43,960
THAT LITTLE MAP ON THE RIGHT

4452
03:00:43,960 --> 03:00:45,680
SIDE OF THE SLIDE, WE HAVE SOME

4453
03:00:45,680 --> 03:00:48,520
OF THEM THREE OR MOROSITIES

4454
03:00:48,520 --> 03:00:51,400
INSIDE THAT SAME PROJECT USING

4455
03:00:51,400 --> 03:00:53,640
THE BEST TALENT AT DIFFERENT

4456
03:00:53,640 --> 03:00:54,440
INSTITUTIONS TO SOLVE THE GOALS

4457
03:00:54,440 --> 03:00:55,880
OF THE SAME PROJECT. SO INSIDE

4458
03:00:55,880 --> 03:00:57,720
THE FUNDING ANNOUNCEMENT AND IN

4459
03:00:57,720 --> 03:00:59,040
THOSE WEBINARS TEACHING THE

4460
03:00:59,040 --> 03:01:01,400
APPLICANTS THAT THIS IS A

4461
03:01:01,400 --> 03:01:03,320
POSSIBILITY REALLY CAN BRING THE

4462
03:01:03,320 --> 03:01:06,200
PEOPLE TOGETHER. 

4463
03:01:06,200 --> 03:01:08,440
>> WHY DON'T WE STOP
THERE, IF

4464
03:01:08,440 --> 03:01:10,720
THERE ARE MORE QUESTIONS THOUGH

4465
03:01:10,720 --> 03:01:13,160
WHY DON'T YOU JUST EMAIL EITHER

4466
03:01:13,160 --> 03:01:15,720
MICHAEL OR LINDA DIRECTLY AND

4467
03:01:15,720 --> 03:01:17,360
PERHAPS COPY WALTER SO HE'S IN

4468
03:01:17,360 --> 03:01:19,160
THAT LOOP. YOU CAN COPY ME AS

4469
03:01:19,160 --> 03:01:21,160
WELL AND USUALLY COPY ALL

4470
03:01:21,160 --> 03:01:22,880
COUNCIL RELATED STUFF SO FEEL

4471
03:01:22,880 --> 03:01:24,800
FREE TO ASK THEM ANY OTHER

4472
03:01:24,800 --> 03:01:26,520
QUESTIONS YOU HAVE OR ANY

4473
03:01:26,520 --> 03:01:28,440
CONCERNS YOU HAVE AND I

4474
03:01:28,440 --> 03:01:30,000
APOLOGIZE FOR THE AGENDA BEING

4475
03:01:30,000 --> 03:01:31,640
SO CRAMMED AT MOMENT. I'M GOING

4476
03:01:31,640 --> 03:01:34,800
TO TRY TO MAKE UP TIME BY

4477
03:01:34,800 --> 03:01:38,360
SKIPPING ALL THE NONSENSE I

4478
03:01:38,360 --> 03:01:39,600
STUFF SAID IN INTRODUCTIONS.  WE

4479
03:01:39,600 --> 03:01:42,760
ARE DOING CONCEPT CLEARANCE NOW

4480
03:01:42,760 --> 03:01:45,320
AND ROD, OUR POINT PERSON FOR

4481
03:01:45,320 --> 03:01:47,880
ALZHEIMERS AND ADRD IS GOING TO

4482
03:01:47,880 --> 03:01:52,360
PRESENT SOME CONCEPTS.  HI ROD.

4483
03:01:52,360 --> 03:01:54,840
CORRIVEAU. OKAY. GO FOR U IT

4484
03:01:54,840 --> 03:01:56,440
>> THANK YOU, BOB. GOOD TO
BE

4485
03:01:56,440 --> 03:01:58,640
HERE TO SAY A FEW WORDS ABOUT

4486
03:01:58,640 --> 03:02:00,920
THE ADRD PROGRAM AND THE CONTEXT

4487
03:02:00,920 --> 03:02:05,200
OF CONCEPT CLEARANCE FOR THIS

4488
03:02:05,200 --> 03:02:09,680
COUNCIL ROUND. THE ALLS MYERS

4489
03:02:09,680 --> 03:02:11,800
DISEASE AND ALSO HAMMERER'S

4490
03:02:11,800 --> 03:02:12,480
DISEASE RELATED DEMENTIA AS I

4491
03:02:12,480 --> 03:02:13,920
DON'T HAVE TO TELL THIS AUDIENCE

4492
03:02:13,920 --> 03:02:16,560
OF COURSE IS IRREVERSIBLE

4493
03:02:16,560 --> 03:02:18,200
PROGRESSIVE BRAIN DISEASE THAT

4494
03:02:18,200 --> 03:02:20,240
AFFECT ALMOST 6 MILLION PEOPLE

4495
03:02:20,240 --> 03:02:21,680
IN THE UNITED STATES. SO MAJOR

4496
03:02:21,680 --> 03:02:24,520
PUBLIC HEALTH ISSUE. AFFECTS THE

4497
03:02:24,520 --> 03:02:27,560
HEALTH AND FINANCES OF

4498
03:02:27,560 --> 03:02:29,720
INDIVIDUALS FAMILIES,

4499
03:02:29,720 --> 03:02:31,400
COMMUNITIES AND SOCIETY.

4500
03:02:31,400 --> 03:02:35,240
CONGRESS IS CHOSEN TO ACT ON

4501
03:02:35,240 --> 03:02:37,240
THIS NATIONAL ALZHEIMER'S

4502
03:02:37,240 --> 03:02:40,480
PROJECT ACT LAW OF 2011,

4503
03:02:40,480 --> 03:02:42,360
PROVIDES AN OPPORTUNITY TO

4504
03:02:42,360 --> 03:02:44,920
ADDRESS ALZHEIMER'S DISEASE AND

4505
03:02:44,920 --> 03:02:48,440
RELATED DEMENTIAS WITH GOAL ONE.

4506
03:02:48,440 --> 03:02:52,240
BEING TO TREAT OR PREVENT AD

4507
03:02:52,240 --> 03:02:58,080
ADRD BY 2025. AT THE NIH NIA

4508
03:02:58,080 --> 03:02:59,040
LEADS THE RESPONSE TO THE

4509
03:02:59,040 --> 03:03:01,560
NATIONAL PLAN TO ADDRESS

4510
03:03:01,560 --> 03:03:05,520
ALZHEIMER'S DISEASE. AD ADRD AND

4511
03:03:05,520 --> 03:03:08,920
NINDS LEADS ACROSS THE NIH, LEWY

4512
03:03:08,920 --> 03:03:12,640
BODY DEMENTIA, FRONTOTEMPORAL

4513
03:03:12,640 --> 03:03:13,640
DEMANE SHAH AND ALZHEIMER'S

4514
03:03:13,640 --> 03:03:14,960
DISEASE RELATED SUMMIT. THE

4515
03:03:14,960 --> 03:03:17,760
NINDS AND THE NIA WORKING TO

4516
03:03:17,760 --> 03:03:19,360
CLOSELY ON FUNDING OPPORTUNITIES

4517
03:03:19,360 --> 03:03:21,880
SUPPLEMENT PROGRAMS TO EXPAND

4518
03:03:21,880 --> 03:03:23,400
THE FIELD PAY LINES YOU HAVE

4519
03:03:23,400 --> 03:03:26,200
SHARED PAY LINES, AS WELL AS

4520
03:03:26,200 --> 03:03:27,640
TRIENNIAL SUMMITS IF YOU LOOK AT

4521
03:03:27,640 --> 03:03:32,240
THE BAR ACROSS THE TOP HERE,

4522
03:03:32,240 --> 03:03:33,840
THERE ARE SUMMIT EACH YEAR WITH

4523
03:03:33,840 --> 03:03:36,000
THE NIA LEADING THE ALZHEIMER'S

4524
03:03:36,000 --> 03:03:39,560
DISEASE SUMMITS, CARE SUMMITS,

4525
03:03:39,560 --> 03:03:41,400
THE NINDS LEADING ALZHEIMER'S

4526
03:03:41,400 --> 03:03:42,600
DISEASE RELATED DEMENTIA

4527
03:03:42,600 --> 03:03:44,400
SUMMITS.  THESE PRODUCE RESEARCH

4528
03:03:44,400 --> 03:03:46,080
RECOMMENDATIONS FOR THE ADRD

4529
03:03:46,080 --> 03:03:47,480
SUMMIT, THEY BECOME MILESTONES,

4530
03:03:47,480 --> 03:03:53,800
IT IS A FACA PROCESS, I WANT TO

4531
03:03:53,800 --> 03:03:56,800
THANK GINA CO-AND TOM CARMICHAEL

4532
03:03:56,800 --> 03:03:59,800
FOR BEING PART OF THAT PROCESS

4533
03:03:59,800 --> 03:04:02,000
AND LOOK TOWARD SCIENTIFIC

4534
03:04:02,000 --> 03:04:03,640
ADVANCES TO WORK ON A GOAL ON TO

4535
03:04:03,640 --> 03:04:10,000
TREAT AD ADRD BY 2025. A PREVIEW

4536
03:04:10,000 --> 03:04:13,640
OF THE OCTOBER COUNCIL, WE WILL

4537
03:04:13,640 --> 03:04:16,960
DO A PRESENTATION ON NIH ADRD

4538
03:04:16,960 --> 03:04:19,200
SUMMIT THAT WAS THIS PAST MARCH

4539
03:04:19,200 --> 03:04:21,280
AND WILL WILL BE A FORMAL REPORT

4540
03:04:21,280 --> 03:04:23,960
TO COUNCIL THAT WILL BE

4541
03:04:23,960 --> 03:04:26,520
PRESENTED, THE SCIENTIFIC CHAIR

4542
03:04:26,520 --> 03:04:28,120
WAS DR.NATELY ROAST WE GRATEFUL

4543
03:04:28,120 --> 03:04:31,200
TO HER FOR THAT WORK THAT SHE

4544
03:04:31,200 --> 03:04:33,600
DID. AND THE TOPICS OF THE

4545
03:04:33,600 --> 03:04:36,800
SUMMIT ARE THE TOPICS THAT ARE

4546
03:04:36,800 --> 03:04:37,880
DESIGNATED BY THE NATIONAL PLAN

4547
03:04:37,880 --> 03:04:41,520
HEALTH EQUITY AND ADRD

4548
03:04:41,520 --> 03:04:43,120
FRONTOTEMPORAL DEGENERATION.

4549
03:04:43,120 --> 03:04:44,160
VASCULAR CONTRIBUTION TO

4550
03:04:44,160 --> 03:04:47,520
COGNITIVE IMPAIRMENT DEMENTIA

4551
03:04:47,520 --> 03:04:49,240
VCID, LEWY BODY AND MULTIPLE

4552
03:04:49,240 --> 03:04:53,240
ETIOLOGY DEMENTIAS. UNDER

4553
03:04:53,240 --> 03:04:54,200
MULTIPLE ETIOLOGY WE HAVE SUB

4554
03:04:54,200 --> 03:04:55,880
TOPICS BECAUSE THEY ALL RELATE

4555
03:04:55,880 --> 03:04:59,080
TO AND ARE RISK FACTORS FOR

4556
03:04:59,080 --> 03:05:00,120
DIDEMENTIA. IT WAS THE FIRST

4557
03:05:00,120 --> 03:05:02,040
TIME WE HAD A VIRTUAL SUMMIT

4558
03:05:02,040 --> 03:05:03,480
THIS PAST MARCH OUT OF

4559
03:05:03,480 --> 03:05:08,760
NECESSITY. AND WE HAD MORE THAN

4560
03:05:08,760 --> 03:05:12,160
1500 ATTENDEES, 400 TO 700

4561
03:05:12,160 --> 03:05:14,400
DURING MOST SESSIONS WITH BROAD

4562
03:05:14,400 --> 03:05:17,080
REPRESENTATION AMONG ACADEMIC

4563
03:05:17,080 --> 03:05:18,520
CLINICAL, GOVERNMENT INDUSTRY

4564
03:05:18,520 --> 03:05:21,280
AND NOT FOR PROFIT AND PUBLIC

4565
03:05:21,280 --> 03:05:23,240
STAKEHOLDERS. I WILL BE TELLING

4566
03:05:23,240 --> 03:05:27,720
YOU MORE ABOUT SUMMIT ALONG WITH

4567
03:05:27,720 --> 03:05:30,280
NATALIA IN SEPTEMBER, THERE ARE

4568
03:05:30,280 --> 03:05:32,520
LINKS AVAILABLE FOR DAY ONE FOR

4569
03:05:32,520 --> 03:05:38,360
BOTH DAYS OF THE SUMMIT AND YOU

4570
03:05:38,360 --> 03:05:40,760
CAN WATCH SUMMIT IF YOU DIDN'T

4571
03:05:40,760 --> 03:05:42,600
HAVE THE OPPORTUNITY. IT WAS

4572
03:05:42,600 --> 03:05:45,200
NICE TO SEE ALL THE OPEN MIC

4573
03:05:45,200 --> 03:05:46,760
TIME THAT WE HAD AVAILABLE

4574
03:05:46,760 --> 03:05:50,680
DURING THE TWO DAYS, 210 MINUTES

4575
03:05:50,680 --> 03:05:53,680
USED VERY WELL I WILL ADD, IT IS

4576
03:05:53,680 --> 03:05:55,520
WONDERFUL THAT WE GOT ALL THAT

4577
03:05:55,520 --> 03:05:59,520
INPUT. FUNDING FOR NINDS AD ADRD

4578
03:05:59,520 --> 03:06:00,320
PROGRAMS IS THROUGH OUR

4579
03:06:00,320 --> 03:06:03,240
PARTNERSHIP WITH THE NIA. AND IF

4580
03:06:03,240 --> 03:06:05,640
YOU LOOK AT THE BLUE HERE ON

4581
03:06:05,640 --> 03:06:09,040
THIS PLOT, YOU CAN SEE NINDS

4582
03:06:09,040 --> 03:06:13,000
INVESTMENT IN AD ADR RESEARCH

4583
03:06:13,000 --> 03:06:14,880
REGULAR NINDS BUDGET AND IN

4584
03:06:14,880 --> 03:06:16,520
YELLOW OR GOLD YOU SEE

4585
03:06:16,520 --> 03:06:18,320
ADDITIONAL FUNDS FROM THE NIA

4586
03:06:18,320 --> 03:06:20,640
FROM CONGRESS AND EARMARKED

4587
03:06:20,640 --> 03:06:25,040
FUNDS FOR AD ADRD RESEARCH. THE

4588
03:06:25,040 --> 03:06:27,720
ADDITIONAL FUNDS FROM NIA ARE

4589
03:06:27,720 --> 03:06:29,480
USED BY THE NINDS TO INCREASE

4590
03:06:29,480 --> 03:06:31,040
INVESTIGATOR INITIATED RESEARCH

4591
03:06:31,040 --> 03:06:32,880
AS WELL AS RESEARCH RESPONSIVE

4592
03:06:32,880 --> 03:06:35,000
TO THE ALZHEIMER'S DISEASE AND

4593
03:06:35,000 --> 03:06:37,440
RELATED DEMENTIA INITIATIVES.

4594
03:06:37,440 --> 03:06:41,520
THREE OF WHICH ARE ON THE AGENDA

4595
03:06:41,520 --> 03:06:47,000
FOR CONCEPT CLEARANCE TODAY.  A

4596
03:06:47,000 --> 03:06:48,480
VERY THUMBNAIL SUMMARY OF THE

4597
03:06:48,480 --> 03:06:50,800
PROGRAM IS THAT THE NINDS HAS

4598
03:06:50,800 --> 03:06:52,960
LED FOUR SUMMITS THAT HAVE SET

4599
03:06:52,960 --> 03:06:55,800
NATIONAL RESEARCH PRIORITIES.

4600
03:06:55,800 --> 03:07:00,200
AND THERE HAVE BEEN MORE THAN 60

4601
03:07:00,200 --> 03:07:01,880
NINDS ALZHEIMER'S DISEASE FUND

4602
03:07:01,880 --> 03:07:03,880
INITIATIVES AND THESE SUPPORTED

4603
03:07:03,880 --> 03:07:05,440
MAJOR PROGRAMS AND CONSORTIA AND

4604
03:07:05,440 --> 03:07:07,440
I DON'T HAVE TIME TO GO OVER

4605
03:07:07,440 --> 03:07:10,800
THEM TODAY BUT YOU CAN SEE LOGOS

4606
03:07:10,800 --> 03:07:14,120
FOR MANY AND MANY FAMILIAR TO

4607
03:07:14,120 --> 03:07:18,680
YOU. THE NIH ALZHEIMER'S DISEASE

4608
03:07:18,680 --> 03:07:20,760
RELATED DEMENTIA RESEARCH

4609
03:07:20,760 --> 03:07:22,240
FUNDING IS INCREASE MORE THAN

4610
03:07:22,240 --> 03:07:26,640
FIVE FOLD SINCE 2015. AND THAT

4611
03:07:26,640 --> 03:07:30,520
IS ALLOWED US TO DO SOME SUPPORT

4612
03:07:30,520 --> 03:07:32,120
TREMENDOUS PROGRAMS THAT ARE

4613
03:07:32,120 --> 03:07:35,720
MOVING FIELD FORWARD.  IN TERMS

4614
03:07:35,720 --> 03:07:38,800
OF CONCEPT CLEARANCE, I JUST

4615
03:07:38,800 --> 03:07:40,920
WANTED TO MENTION THAT BEFORE

4616
03:07:40,920 --> 03:07:43,200
THE CONCEPTS COME TO COUNCIL

4617
03:07:43,200 --> 03:07:45,760
THEY GO THROUGH A PRETTY

4618
03:07:45,760 --> 03:07:48,800
RIGOROUS PROCESS. THE SUMMIT

4619
03:07:48,800 --> 03:07:49,960
MILESTONES ARE DELIVERED TO THE

4620
03:07:49,960 --> 03:07:51,280
DEPARTMENT OF HEALTH AND HUMAN

4621
03:07:51,280 --> 03:07:56,160
SERVICES, AND THEY INFORM ALL OF

4622
03:07:56,160 --> 03:07:57,440
US REALLY AT THE NINDS PROGRAM

4623
03:07:57,440 --> 03:08:00,560
STAFF LEADERSHIP AND

4624
03:08:00,560 --> 03:08:04,640
DISCUSSIONS, ABOUT THE CONCEPTS,

4625
03:08:04,640 --> 03:08:05,760
ANNUALLY, THAT STARTED IN SPRING

4626
03:08:05,760 --> 03:08:07,520
OR SUMMER AND CONTINUED THROUGH

4627
03:08:07,520 --> 03:08:09,680
THE FALL, DIRECTOR IS INVOLVED,

4628
03:08:09,680 --> 03:08:14,440
THE NIA IS INVOLVED, AND

4629
03:08:14,440 --> 03:08:16,360
ULTIMATELY THESE CONCEPTS ARE

4630
03:08:16,360 --> 03:08:18,760
DEVELOPED AND DISCUSSED AND HAVE

4631
03:08:18,760 --> 03:08:20,360
BEEN VETTED BY THE NINDS

4632
03:08:20,360 --> 03:08:25,920
DIRECTOR AS WELL AS THE NIA

4633
03:08:25,920 --> 03:08:29,920
DIRECTOR BEFORE THEY COME TO

4634
03:08:29,920 --> 03:08:32,840
COUNCIL HERE. ONCE WE HOPE THE

4635
03:08:32,840 --> 03:08:34,800
CONCEPTS ARE APPROVED, THEY ARE

4636
03:08:34,800 --> 03:08:36,560
FURTHER WORKEDDED UP FOR

4637
03:08:36,560 --> 03:08:37,440
IMPLEMENTATION, TYPICALLY IN THE

4638
03:08:37,440 --> 03:08:40,600
FOLLOWING FISCAL YEAR. SOMETIMES

4639
03:08:40,600 --> 03:08:43,160
WE ARE ABLE TO PLAN, WE HOPE TO

4640
03:08:43,160 --> 03:08:44,640
PLAN MORE UP TO TWO YEARS IN

4641
03:08:44,640 --> 03:08:46,800
ADVANCE AND JUST MAKES A LOT OF

4642
03:08:46,800 --> 03:08:48,480
THINGS WORK VERY SMOOTHLY IF WE

4643
03:08:48,480 --> 03:08:52,080
CAN PLAN THAT FAR IN ADVANCE. 

4644
03:08:52,080 --> 03:08:55,240
THIS IS A LARGE PROGRAM WITH A

4645
03:08:55,240 --> 03:08:59,120
LOT OF EFFORT BY LOT OF PEOPLE,

4646
03:08:59,120 --> 03:09:01,560
AND IT IS HARD TO DO JUSTICE TO

4647
03:09:01,560 --> 03:09:04,240
IT BUT I AM GRATEFUL TO

4648
03:09:04,240 --> 03:09:06,400
EVERYBODY FOR THEIR TREMENDOUS

4649
03:09:06,400 --> 03:09:07,600
EFFORTS CREATIVE EFFORTS IN

4650
03:09:07,600 --> 03:09:11,000
MAKING THIS PROGRAM A SUCCESS.

4651
03:09:11,000 --> 03:09:14,240
WE HAVE THREE CONCEPTS THAT ARE

4652
03:09:14,240 --> 03:09:17,800
FOR CONCEPT CLEARANCE. ONE OF

4653
03:09:17,800 --> 03:09:20,560
THEM, YOU CAN SEE THAT I HAVE

4654
03:09:20,560 --> 03:09:22,520
NAMED THE PROGRAM LEAD WILL

4655
03:09:22,520 --> 03:09:24,600
DAILY IS THE LEAD OF A CONCEPT

4656
03:09:24,600 --> 03:09:27,360
CALLED CELLULAR MOLECULAR

4657
03:09:27,360 --> 03:09:29,720
MECHANISMS OF PRYION LIKE

4658
03:09:29,720 --> 03:09:31,160
SEEDING AGGREGATION AN

4659
03:09:31,160 --> 03:09:34,440
NEUROTOXICITY IN ADRD, REBECCA

4660
03:09:34,440 --> 03:09:36,360
HUMMER IS LEAD FOR AMYLOID FOR

4661
03:09:36,360 --> 03:09:37,960
POPULATIONS WITH VASCULAR RISK

4662
03:09:37,960 --> 03:09:41,040
OF COGNITIVE IMPAIRMENT AND

4663
03:09:41,040 --> 03:09:43,240
DEMENTIA AND (INAUDIBLE) IS THE

4664
03:09:43,240 --> 03:09:44,680
LEAD FOR NEUROPATHOLOGICAL

4665
03:09:44,680 --> 03:09:47,160
ASSESSMENT OF TBI RELATED

4666
03:09:47,160 --> 03:09:47,880
NEURODEGENERATION AND

4667
03:09:47,880 --> 03:09:52,440
NEUROCOGNITIVE DECLINE. WITH

4668
03:09:52,440 --> 03:09:54,840
THAT I WILL PAUSE. I KNOW YOU

4669
03:09:54,840 --> 03:09:56,080
HAVE SEEN THE MATERIALS AND SEE

4670
03:09:56,080 --> 03:09:57,200
IF ANYBODY HAS ANY QUESTIONS

4671
03:09:57,200 --> 03:10:01,920
ABOUT THESE. 

4672
03:10:01,920 --> 03:10:04,520
>> OKAY. ARE THERE ANY
QUESTIONS

4673
03:10:04,520 --> 03:10:09,000
FOR ROD? FOR THEIR RESPECTIVE

4674
03:10:09,000 --> 03:10:16,480
PROGRAM DIRECTORS? DID YOU HAVE

4675
03:10:16,480 --> 03:10:19,080
MORE, THAT IS ALL.

4676
03:10:19,080 --> 03:10:25,920
>> WHAT WE NEED IS A
MOTION TO

4677
03:10:25,920 --> 03:10:28,280
APPROVE OR DISAPPROVE THESE

4678
03:10:28,280 --> 03:10:29,880
THREE INITIATIVE CONCEPTS, THEY

4679
03:10:29,880 --> 03:10:35,680
ARE COMING FROM THE ALZHEIMER

4680
03:10:35,680 --> 03:10:36,760
DIRECTED FUNDS SO WE NEED A

4681
03:10:36,760 --> 03:10:37,320
MOTION TO APPROVE.

4682
03:10:37,320 --> 03:10:39,920
>> MOTION TO APPROVE.

4683
03:10:39,920 --> 03:10:43,160
>> SECOND. OKAY. LET'S USE
THE

4684
03:10:43,160 --> 03:10:44,640
CHAT TO VOTE ON THESE THREE

4685
03:10:44,640 --> 03:10:53,320
TOGETHER. THANKS A LOT ROD,

4686
03:10:53,320 --> 03:10:56,840
APPRECIATE YOUR BREVERY AS WELL 

4687
03:10:56,840 --> 03:10:58,880
IF THERE ARE QUESTIONS OR ROD,

4688
03:10:58,880 --> 03:11:02,120
OUR STAFF IS GETTING SLICK WE

4689
03:11:02,120 --> 03:11:03,520
ARE REALLY ARE SOUNDING LIKE A

4690
03:11:03,520 --> 03:11:05,280
DRUG COMPANY NOWADAYS. IF THERE

4691
03:11:05,280 --> 03:11:06,400
ARE QUESTIONS FOR ROD FEEL FREE

4692
03:11:06,400 --> 03:11:08,840
TO REACH OUT TO HIM AND HE CAN

4693
03:11:08,840 --> 03:11:10,880
RELAY QUESTIONS TO THE RELEVANT

4694
03:11:10,880 --> 03:11:16,040
PROGRAM PEOPLE. THE OTHER

4695
03:11:16,040 --> 03:11:16,600
INITIATIVE TALK ABOUT

4696
03:11:16,600 --> 03:11:18,000
SPECIFICALLY IS REISSUES ON A

4697
03:11:18,000 --> 03:11:20,920
SLIDE THAT WE WON'T TALK ABOUT

4698
03:11:20,920 --> 03:11:24,000
UNLESS YOU HAVE QUESTIONS. IS

4699
03:11:24,000 --> 03:11:26,360
DAN MILLER, DAN DO YOU HAVE YOUR

4700
03:11:26,360 --> 03:11:28,440
SLIDE READY TO PUT UP? WELCOME,

4701
03:11:28,440 --> 03:11:31,880
BOB BROWN.

4702
03:11:31,880 --> 03:11:34,440
>> ARE WE SUPPOSED TO VOTE
ON

4703
03:11:34,440 --> 03:11:35,840
THE HEAL CONCEPT?

4704
03:11:35,840 --> 03:11:37,960
>> THE HEAL CONCEPT WE
WANTED

4705
03:11:37,960 --> 03:11:38,880
YOU YOU ARE FEEDBACK FORMALLY

4706
03:11:38,880 --> 03:11:40,120
SPEAKING WE DON'T NEED TO

4707
03:11:40,120 --> 03:11:44,520
APPROVE CONCEPTS FOR HEAL.

4708
03:11:44,520 --> 03:11:45,560
CREATE NATIONAL EMERGENCY, WE

4709
03:11:45,560 --> 03:11:50,120
HAVE AUTOMATIC APPROVAL BUT

4710
03:11:50,120 --> 03:11:50,880
WALTER WANTS THE SEE EVERYTHING

4711
03:11:50,880 --> 03:11:53,040
YOU ARE PROPOSING TO DO. I

4712
03:11:53,040 --> 03:11:54,200
APOLOGIZE FOR THINGS BEING

4713
03:11:54,200 --> 03:11:56,880
RUSHED TODAY.

4714
03:11:56,880 --> 03:11:58,120
>> THANKS.

4715
03:11:58,120 --> 03:12:01,640
>> SO DAN, KELLY, TONY, HE

4716
03:12:01,640 --> 03:12:03,320
DOESN'T HAVE ACCESS TO SHARE HIS

4717
03:12:03,320 --> 03:12:07,080
SLIDE. T WE WILL HAVE A COPY OF

4718
03:12:07,080 --> 03:12:12,160
YOUR SLIDE. IS ACCESS SOMETHING

4719
03:12:12,160 --> 03:12:16,520
TO GRANT TIM OR BROOK?

4720
03:12:16,520 --> 03:12:18,640
>> YOU HAVE TO CLICK THE
PROMOTE

4721
03:12:18,640 --> 03:12:21,960
BUTTON. DID YOU HEAR THAT, CLICK

4722
03:12:21,960 --> 03:12:23,680
THE PROMOTE BUTTON. WHATEVER

4723
03:12:23,680 --> 03:12:33,920
THAT MEANS. 

4724
03:12:34,640 --> 03:12:42,880
>> THERE WE GO. WE SEE IT.
WE

4725
03:12:42,880 --> 03:12:46,920
DON'T SEE OR HEAR YOU.

4726
03:12:46,920 --> 03:12:49,440
>> THANKS DAN.

4727
03:12:49,440 --> 03:12:51,520
>> IS THIS IN PROPER MODE?

4728
03:12:51,520 --> 03:12:54,880
>> NOT IN PRESENTATION
MODE. IT

4729
03:12:54,880 --> 03:12:58,800
IS THE OTHER SIDE OF THE SCREEN.

4730
03:12:58,800 --> 03:13:01,880
THAT IS RIGHT. GO FOR IT. 

4731
03:13:01,880 --> 03:13:04,080
>> THANKS, EVERYBODY. I'M
DAN

4732
03:13:04,080 --> 03:13:05,680
MILLER, THIS IS A CONCEPT THAT

4733
03:13:05,680 --> 03:13:07,600
I'M BRINGING TO YOU FOR

4734
03:13:07,600 --> 03:13:09,360
ACCORDANCE THAT WAS PUT TOGETHER

4735
03:13:09,360 --> 03:13:13,640
BY A NUMBER OF US AT NINDS.

4736
03:13:13,640 --> 03:13:15,520
FOCUSED ON STRATEGIES TO

4737
03:13:15,520 --> 03:13:16,920
INCREASE DIVERSE NEUROTYPICAL

4738
03:13:16,920 --> 03:13:20,680
BRAIN DONATION.  SO IT IS

4739
03:13:20,680 --> 03:13:22,800
CONCEIVED AS A MULTI-IC

4740
03:13:22,800 --> 03:13:24,160
INITIATIVE THAT REALLY AIMS TO

4741
03:13:24,160 --> 03:13:27,520
ADDRESS TWO OF THE TOP

4742
03:13:27,520 --> 03:13:30,160
CHALLENGES THAT BRAIN BANKS HAVE

4743
03:13:30,160 --> 03:13:32,560
BEEN FACED TO HAVE

4744
03:13:32,560 --> 03:13:34,400
REPRESENTATIVE TUSH SHOE

4745
03:13:34,400 --> 03:13:39,120
ESSENTIALLY IN OUR BANKS THAT

4746
03:13:39,120 --> 03:13:40,840
REPRESENT ALL VARIATION THAT

4747
03:13:40,840 --> 03:13:44,400
EXISTS IN US SOCIETY.

4748
03:13:44,400 --> 03:13:47,040
IMPORTANTLY ACROSS ALL DISEASE

4749
03:13:47,040 --> 03:13:50,680
TYPES. IT IS ONE THING TO HAVE A

4750
03:13:50,680 --> 03:13:51,760
PERCENTAGE OF CERTAIN ANCESTRY

4751
03:13:51,760 --> 03:13:54,760
OR RACE IN YOUR BANK THAT LOOKS

4752
03:13:54,760 --> 03:13:56,640
DECENT OR LOOKS REPRESENTATIVE.

4753
03:13:56,640 --> 03:13:58,840
IT IS ANOTHER THING TO HAVE THAT

4754
03:13:58,840 --> 03:14:02,520
REPRESENTATION ACROSS REALLY

4755
03:14:02,520 --> 03:14:04,040
DISEASE TYPES IN WHICH TISSUE IS

4756
03:14:04,040 --> 03:14:07,160
-- NEEDS TO BE STUDIED. THE

4757
03:14:07,160 --> 03:14:09,320
OTHER MAIN CHALLENGE WE HAVE IS

4758
03:14:09,320 --> 03:14:13,000
ACCESS TO NEUROTYPICAL TISSUE. I

4759
03:14:13,000 --> 03:14:15,360
THINK YOU ARE PROBABLY ALL AWARE

4760
03:14:15,360 --> 03:14:19,240
THAT IT IS CRITICAL TO HAVE

4761
03:14:19,240 --> 03:14:22,400
NORMAL HUMAN BRAIN TISSUE

4762
03:14:22,400 --> 03:14:24,560
AVAILABLE TO UNDERSTAND HOW THE

4763
03:14:24,560 --> 03:14:26,480
BRAIN WORKS. IT IS ALSO EXREAMLY

4764
03:14:26,480 --> 03:14:28,200
IMPORTANT AS ESSENTIALLY CONTROL

4765
03:14:28,200 --> 03:14:29,320
OR COMPARATIVE TISSUE FOR

4766
03:14:29,320 --> 03:14:32,880
DISEASE FOCUS STUDIES.  SO

4767
03:14:32,880 --> 03:14:35,280
EARLIER LAST YEAR WE HELD A

4768
03:14:35,280 --> 03:14:37,800
WORKSHOP CALLED TISSUE QUALITY

4769
03:14:37,800 --> 03:14:41,000
PIPELINE FOR HUMAN BRAIN CENSUS

4770
03:14:41,000 --> 03:14:42,920
WORKSHOP, ESSENTIALLY DEALT WITH

4771
03:14:42,920 --> 03:14:46,000
HUMAN BRAIN TISSUE NEEDS THAT WE

4772
03:14:46,000 --> 03:14:48,080
ARE FACING GIVEN BRAIN

4773
03:14:48,080 --> 03:14:50,080
INITIATIVE RAMP UP IN THE HUMAN

4774
03:14:50,080 --> 03:14:54,200
CELL CENSUS. AND EVEN THOUGH

4775
03:14:54,200 --> 03:14:58,120
REALLY THE WORKSHOP WAS FOCUSED

4776
03:14:58,120 --> 03:14:59,680
ATLASSING AND NEED FOR ATLASSING

4777
03:14:59,680 --> 03:15:00,920
THESE TWO TOPICS BUBBLED TO THE

4778
03:15:00,920 --> 03:15:05,320
TOP. I THINK YOU WILL SEE WHY

4779
03:15:05,320 --> 03:15:08,240
LATER. AND THE TWO TOPICS THAT

4780
03:15:08,240 --> 03:15:09,920
THEY IDENTIFIED AND MADE A

4781
03:15:09,920 --> 03:15:11,560
RECOMMENDATION ON ARE REALLY

4782
03:15:11,560 --> 03:15:14,440
DONOR DIVERSITY HOW WE GET OUR

4783
03:15:14,440 --> 03:15:19,720
HANDS ON DIVERSE TISSUE. HOW CAN

4784
03:15:19,720 --> 03:15:21,080
WE MAKE SURE THAT WE HAVE

4785
03:15:21,080 --> 03:15:22,280
SUFFICIENT NEUROTYPICAL TISSUE

4786
03:15:22,280 --> 03:15:25,640
IN OUR BANKS. THEY MAKE SPECIFIC

4787
03:15:25,640 --> 03:15:27,800
RECOMMENDATIONS, THE FIRST ONE

4788
03:15:27,800 --> 03:15:31,680
FOR DONATION IS SOMEWHAT

4789
03:15:31,680 --> 03:15:32,680
OBVIOUS, BUT VERY IMPORTANT,

4790
03:15:32,680 --> 03:15:36,200
TARGETED OUTREACH, ENGAGEMENT TO

4791
03:15:36,200 --> 03:15:38,400
COMMUNITIES CURRENTLY

4792
03:15:38,400 --> 03:15:39,600
UNDERBANKED. TO INCREASE ACCESS

4793
03:15:39,600 --> 03:15:41,120
AND COLLECTION OF NEUROTYPICAL

4794
03:15:41,120 --> 03:15:46,360
TISSUES THEY SUGGEST THAT WE DO

4795
03:15:46,360 --> 03:15:48,840
THINGS THAT SUPPORT NEW

4796
03:15:48,840 --> 03:15:50,400
COLLABORATION BETWEEN BANKS

4797
03:15:50,400 --> 03:15:51,560
TISSUE BANKS AND LOCATIONS WHERE

4798
03:15:51,560 --> 03:15:53,760
THESE TISSUES ARE COLLECTED SO

4799
03:15:53,760 --> 03:15:58,680
MEDICAL EXAMINERS OFFICE,

4800
03:15:58,680 --> 03:15:59,960
OPOs. I DON'T KNOW HOW

4801
03:15:59,960 --> 03:16:01,320
NECESSARY IT IS BUT I WANT THE

4802
03:16:01,320 --> 03:16:05,280
GIVE YOU A QUICK IDEA OF WHY

4803
03:16:05,280 --> 03:16:07,480
DIVERSITY IS AN ISSUE IN BRAIN

4804
03:16:07,480 --> 03:16:11,400
BANKING AND THERE IS A LOT SAID

4805
03:16:11,400 --> 03:16:12,600
ABOUT UNDERREPRESENTATION

4806
03:16:12,600 --> 03:16:14,040
CLINICAL STUDIES, THERE'S

4807
03:16:14,040 --> 03:16:15,800
ACTUALLY A LOT PUBLISHED OR

4808
03:16:15,800 --> 03:16:19,520
IMPORTANT PAPERS PUBLISHED ON

4809
03:16:19,520 --> 03:16:20,560
THE LACK OF REPRESENTATIVE

4810
03:16:20,560 --> 03:16:21,880
DIVERSITY AND BRAIN BANKING

4811
03:16:21,880 --> 03:16:24,800
ACTUALLY SPECIFICALLY. BUT I

4812
03:16:24,800 --> 03:16:26,400
WILL GIVE YOU SOME NUMBERS THAT

4813
03:16:26,400 --> 03:16:29,160
SHOW WHAT IS GOING ON IN THE NIH

4814
03:16:29,160 --> 03:16:31,920
BIOBANK WHICH IS PROBABLY

4815
03:16:31,920 --> 03:16:34,280
NATION'S LARGEST HUMAN BRAIN

4816
03:16:34,280 --> 03:16:37,400
BANK. SO THESE ARE -- WE COLLECT

4817
03:16:37,400 --> 03:16:39,200
THIS DATA IN TWO WAYS RACE AND

4818
03:16:39,200 --> 03:16:40,640
ETHNICITY SO I'M SHOWING IT IN

4819
03:16:40,640 --> 03:16:45,520
TWO WAYS BUT I THINK THE POINT

4820
03:16:45,520 --> 03:16:50,160
CAN BE MADE, IN THIS WAY. SO IN

4821
03:16:50,160 --> 03:16:52,760
BLUE IS THE DATA WE COLLECT ON

4822
03:16:52,760 --> 03:16:54,000
RACE AND ORANGE IS DATA WE

4823
03:16:54,000 --> 03:16:55,680
COLLECT ON ETHNICITY AND WHAT IT

4824
03:16:55,680 --> 03:16:59,080
SHOWS US IS THAT OUR NUMBERS FOR

4825
03:16:59,080 --> 03:17:01,960
BLACK OR AFRICAN AMERICAN DONORS

4826
03:17:01,960 --> 03:17:04,440
IN BIOBANK IS DECENT.  IT IS

4827
03:17:04,440 --> 03:17:06,680
NUMBER THAT NEUROBIOBANK IS

4828
03:17:06,680 --> 03:17:10,280
PROUD OF AND OVER YEARS AND IS

4829
03:17:10,280 --> 03:17:12,120
HAPPY TO SHOW. I THINK THE DEVIL

4830
03:17:12,120 --> 03:17:13,920
IS IN THE DETAILS AND IF I HAVE

4831
03:17:13,920 --> 03:17:16,720
TIME I WILL GO INTO THAT LATER.

4832
03:17:16,720 --> 03:17:20,320
IF WE LOOK AT ASIAN DONORS OR

4833
03:17:20,320 --> 03:17:22,960
HISPANIC AND LATINO DONORS THE

4834
03:17:22,960 --> 03:17:25,040
NUMBERS ARE QUITE BAD IF NOT

4835
03:17:25,040 --> 03:17:25,800
ABYSMAL, THIS IS REALLY

4836
03:17:25,800 --> 03:17:27,000
SOMETHING THAT I THINK WE NEED

4837
03:17:27,000 --> 03:17:30,400
TO ADDRESS. AND THAT THIS EFFORT

4838
03:17:30,400 --> 03:17:32,120
WANTS TO ADDRESS, LET ME LOOK AT

4839
03:17:32,120 --> 03:17:35,400
TIME HERE.  I WANT TO TALK ABOUT

4840
03:17:35,400 --> 03:17:39,880
THE BLACK AFRICAN AMERICAN

4841
03:17:39,880 --> 03:17:43,680
COMPONENT IN THE NEUROBIOBANK.

4842
03:17:43,680 --> 03:17:47,520
IF YOU TAKE A LOOK AT WHERE

4843
03:17:47,520 --> 03:17:49,400
TISSUE BLACK AFRICAN AMERICAN

4844
03:17:49,400 --> 03:17:52,920
DONORS IS BANKED, I GAVE A BIG

4845
03:17:52,920 --> 03:17:54,800
SORT OF EAGLE EYE OVERVIEW TO

4846
03:17:54,800 --> 03:17:57,040
MAKE MY POINT, YOU WILL FIND

4847
03:17:57,040 --> 03:17:59,720
THAT MORE THAN HALF OF THE

4848
03:17:59,720 --> 03:18:02,520
TISSUE IS BANKED IN THESE THREE

4849
03:18:02,520 --> 03:18:04,760
SITES, HPCC, MARYLAND, AND

4850
03:18:04,760 --> 03:18:06,680
MARYLAND PSYCHIATRIC BANK. THE

4851
03:18:06,680 --> 03:18:09,480
HPCC IS INTRAMURAL NIH BANK AND

4852
03:18:09,480 --> 03:18:10,560
MARYLAND PSYCHIATRIC BANK LIKE

4853
03:18:10,560 --> 03:18:12,720
THE NIMH BANK ARE HEAVILY

4854
03:18:12,720 --> 03:18:14,680
FOCUSED ON PSYCHIATRIC

4855
03:18:14,680 --> 03:18:16,680
DISORDERS. THE MARYLAND BANK IS

4856
03:18:16,680 --> 03:18:18,880
OUR PEDIATRIC BANK SO THEY ARE

4857
03:18:18,880 --> 03:18:22,720
AGENTS OF DONORS ARE VERY YOUNG.

4858
03:18:22,720 --> 03:18:25,520
SO IF YOU LOOK AT THE AGE

4859
03:18:25,520 --> 03:18:27,000
DISTRIBUTION, ESSENTIALLY WHAT

4860
03:18:27,000 --> 03:18:30,360
THIS TELLS US IS THAT HBCC AND

4861
03:18:30,360 --> 03:18:32,880
MARYLAND PSYCHIATRIC HAVE A VERY

4862
03:18:32,880 --> 03:18:34,640
LARGE COMPONENT PROPORTIONALLY

4863
03:18:34,640 --> 03:18:36,400
OF BLACK AFRICAN AMERICAN TISSUE

4864
03:18:36,400 --> 03:18:38,240
BUT IT IS GOING TO BE HEAVILY

4865
03:18:38,240 --> 03:18:39,880
SKEWED TOWARDS PSYCHIATRIC

4866
03:18:39,880 --> 03:18:43,520
DISORDERS. WHAT THE MARYLAND

4867
03:18:43,520 --> 03:18:45,200
COLLECTION ESSENTIALLY TELLS US

4868
03:18:45,200 --> 03:18:46,840
IS THAT THE AFRICAN AMERICAN

4869
03:18:46,840 --> 03:18:48,240
DONORS THAT WE HAVE WILL BE

4870
03:18:48,240 --> 03:18:49,920
ADDITIONALLY SKEWED TOWARDS

4871
03:18:49,920 --> 03:18:52,720
YOUNG DONORS. THAT IS

4872
03:18:52,720 --> 03:18:54,400
ESSENTIALLY WHAT THE DATA SHOWS

4873
03:18:54,400 --> 03:18:55,920
IF YOU LOOK AT THE GRAPH ON THE

4874
03:18:55,920 --> 03:18:57,480
RIGHT THE BLUE BARS ARE THE

4875
03:18:57,480 --> 03:18:59,760
NEUROBIOBANK AND IF YOU IGNORE 0

4876
03:18:59,760 --> 03:19:01,520
TO 10 THAT IS ESSENTIALLY THE

4877
03:19:01,520 --> 03:19:02,400
AGE DISTRIBUTION ONE WOULD

4878
03:19:02,400 --> 03:19:04,160
EXPECT OF A BRAIN BANK, THE

4879
03:19:04,160 --> 03:19:07,920
OLDER THE MORE. WE DO HAVE A LOT

4880
03:19:07,920 --> 03:19:10,480
OF 0 TO 10 BECAUSE MARYLAND IS

4881
03:19:10,480 --> 03:19:14,760
VERY FOCUSED ON PEDIATRIC CASES.

4882
03:19:14,760 --> 03:19:16,680
AND EVEN HPCC AND MARYLAND

4883
03:19:16,680 --> 03:19:19,480
PSYCHIATRIC BANK IS ALSO GOING

4884
03:19:19,480 --> 03:19:21,120
TO BE VERY SKEWED HEAVILY

4885
03:19:21,120 --> 03:19:24,800
TOWARDS YOUNGER CASES.  SO I

4886
03:19:24,800 --> 03:19:26,240
THINK WHAT IT TELLS US IS HOE

4887
03:19:26,240 --> 03:19:28,120
THE BLACK AFRICAN AMERICAN

4888
03:19:28,120 --> 03:19:30,160
NUMBER LOOKS GOOD, AND IS

4889
03:19:30,160 --> 03:19:31,720
ACTUALLY GOOD COMPARED TO OTHER

4890
03:19:31,720 --> 03:19:32,880
BANKS WE STILL HAVE WORK TO DO

4891
03:19:32,880 --> 03:19:35,760
TO MAKE SURE THAT WE HAVE

4892
03:19:35,760 --> 03:19:36,760
REPRESENTATION OF BLACK AND

4893
03:19:36,760 --> 03:19:39,640
AFRICAN AMERICAN AND ALL

4894
03:19:39,640 --> 03:19:40,800
ANCESTRIES RACE ACROSS ALL THE

4895
03:19:40,800 --> 03:19:42,720
DISEASE TYPES THAT ARE IMPORTANT

4896
03:19:42,720 --> 03:19:46,280
TO BE STUDIED. I WANT TO QUICKLY

4897
03:19:46,280 --> 03:19:49,920
ALSO GIVE YOU AN IDEA OF WHY

4898
03:19:49,920 --> 03:19:50,640
NEUROTYPICAL COLLECTION IS

4899
03:19:50,640 --> 03:19:54,640
REALLY COMING TO THE FORE FRONT

4900
03:19:54,640 --> 03:19:56,280
FOR COLLECTION OF NEUROTYPICAL

4901
03:19:56,280 --> 03:19:57,920
TISSUE COMING THE FOREFRONT NOW.

4902
03:19:57,920 --> 03:20:00,560
AND THAT MANY OF YOU ARE AWARE

4903
03:20:00,560 --> 03:20:04,680
COMES FROM SET OF RFAs AND

4904
03:20:04,680 --> 03:20:06,080
GROUP OF INITIATIVES THAT ARE

4905
03:20:06,080 --> 03:20:08,000
COMING OUT OF THE BRAIN

4906
03:20:08,000 --> 03:20:10,200
INITIATIVE CALLED BUY CAN, THE

4907
03:20:10,200 --> 03:20:11,720
BRAIN CELL CENSUS BRAIN

4908
03:20:11,720 --> 03:20:15,000
INITIATIVE CELL ATLAS NETWORK.

4909
03:20:15,000 --> 03:20:18,880
WHERE A LOT OF MONEY IS BEING

4910
03:20:18,880 --> 03:20:22,680
SPENT TO DEVELOP A ATLAS ALL

4911
03:20:22,680 --> 03:20:25,280
CELL TYPES IN THE HUMAN BRAIN.

4912
03:20:25,280 --> 03:20:30,680
NORMAL HUMAN BRAIN. THIS REALLY

4913
03:20:30,680 --> 03:20:35,320
REQUIRES SOME SPECIAL

4914
03:20:35,320 --> 03:20:38,000
CONSIDERATIONS, SO IT IS A CLEAR

4915
03:20:38,000 --> 03:20:40,960
GOAL OF THE CELL CENSUS THAT

4916
03:20:40,960 --> 03:20:42,280
ATLAS REPRESENTS HUMAN DIVERSITY

4917
03:20:42,280 --> 03:20:46,760
AS WE FIND IT NOT CELL TYPES,

4918
03:20:46,760 --> 03:20:51,520
SOME LOOKS LIKE ME OLDS BLACK

4919
03:20:51,520 --> 03:20:53,200
GUY BUT REFLECT IT IS DIVERSITY

4920
03:20:53,200 --> 03:20:55,480
THAT WE HAVE. AND WE WILL NEED

4921
03:20:55,480 --> 03:20:57,400
NORMAL OR NON-DISEASE TISSUE FOR

4922
03:20:57,400 --> 03:21:00,800
THIS, THAT IS PREPARED IN A WAY

4923
03:21:00,800 --> 03:21:02,480
THAT SUITS THESE VERY MODERN

4924
03:21:02,480 --> 03:21:03,640
ASSAYS THAT WILL BE APPLIED. 

4925
03:21:03,640 --> 03:21:04,760
FOR THAT THE BRAIN INITIATIVE

4926
03:21:04,760 --> 03:21:07,520
HAS TEAMED UP WITH THE

4927
03:21:07,520 --> 03:21:09,640
NEUROBIOBANK AND CREATED THE

4928
03:21:09,640 --> 03:21:11,240
HUMAN BRAIN CELL ATLAS

4929
03:21:11,240 --> 03:21:14,160
COLLECTION CALLED HBCAC.  WE ARE

4930
03:21:14,160 --> 03:21:15,720
TASKED WITH OVER THE NEXT FOUR

4931
03:21:15,720 --> 03:21:18,360
TO FIVE YEARS COLLECTING 200 TO

4932
03:21:18,360 --> 03:21:19,160
300F PREPARED

4933
03:21:19,160 --> 03:21:21,200
AND PROCESSED NEUROTYPICAL

4934
03:21:21,200 --> 03:21:23,680
BRAINS FOR THE ATLASSING EFFORT.

4935
03:21:23,680 --> 03:21:25,760
SO THAT INVOLVES THE

4936
03:21:25,760 --> 03:21:27,840
STANDARDIZED COLLECTION PROCESS,

4937
03:21:27,840 --> 03:21:29,720
SPECIALIZED METHODS FOR THE

4938
03:21:29,720 --> 03:21:31,840
ASSAYS THAT WILL BE APPLIED

4939
03:21:31,840 --> 03:21:33,440
IMAGING SAMPLES CAN BE

4940
03:21:33,440 --> 03:21:34,960
REGISTERED BACK ON TO ATLAS. AND

4941
03:21:34,960 --> 03:21:37,360
WE HAVE TO MEET THE INCLUSION

4942
03:21:37,360 --> 03:21:38,520
GOALS WHICH IS BROAD DIVERSITY

4943
03:21:38,520 --> 03:21:41,000
OF NEUROTYPICAL DONORS. SO THE

4944
03:21:41,000 --> 03:21:43,040
EFFORT WE ARE PROPOSING HERE

4945
03:21:43,040 --> 03:21:44,120
ISN'T REALLY -- IT IS MORE LONG

4946
03:21:44,120 --> 03:21:45,280
TERM, IT IS NOT NECESSARILY

4947
03:21:45,280 --> 03:21:48,840
GOING TO HELP US ACHIEVE THOSE

4948
03:21:48,840 --> 03:21:50,920
GOALS THAT WE HAVE, IT WILL HELP

4949
03:21:50,920 --> 03:21:56,120
US BACK FILL, THIS WILL

4950
03:21:56,120 --> 03:22:00,440
ESSENTIALLY SOMEWHAT -- THIS

4951
03:22:00,440 --> 03:22:02,280
WILL PUT A LARGE BURDEN ON

4952
03:22:02,280 --> 03:22:03,440
COLLECTION OF NEUROTYPICAL

4953
03:22:03,440 --> 03:22:05,400
TISSUE THAT WILL NOT THEN BE

4954
03:22:05,400 --> 03:22:09,280
AVAILABLE FOR PEOPLE STUDYING

4955
03:22:09,280 --> 03:22:11,120
ALZHEIMER'S PD SCHIZOPHRENIA, SO

4956
03:22:11,120 --> 03:22:16,400
ON SO WE NEED TO BACK FILL THOSE

4957
03:22:16,400 --> 03:22:18,720
BRAINS AND THAT IS WHAT WE HOPE

4958
03:22:18,720 --> 03:22:20,560
WILL BE HELPING US TO DO. SO I

4959
03:22:20,560 --> 03:22:22,680
WANT TO GIVE A LITTLE DETAIL ON

4960
03:22:22,680 --> 03:22:25,160
EXACTLY HOW WE WERE RECOMMENDED

4961
03:22:25,160 --> 03:22:30,600
TO DO THIS. WE WILL TALK ABOUT

4962
03:22:30,600 --> 03:22:31,520
OUTREACH ENGAGEMENT PART, WE

4963
03:22:31,520 --> 03:22:34,400
WANT TO LEVERAGE ONGOING NIH

4964
03:22:34,400 --> 03:22:37,440
STUDIES, CLINICAL STUDIES THAT

4965
03:22:37,440 --> 03:22:40,480
HAVE ACTIVE ENGAGEMENT PARTNERS

4966
03:22:40,480 --> 03:22:42,480
THAT ARE CURRENTLY TALKING TO

4967
03:22:42,480 --> 03:22:45,080
THOSE UNDERSERVED COMMUNITIES

4968
03:22:45,080 --> 03:22:47,880
THAT ARE NOT BANKING. WE WOULD

4969
03:22:47,880 --> 03:22:51,560
LIKE TO SUPPLEMENT AND ADD FUNDS

4970
03:22:51,560 --> 03:22:52,720
TO THEIR PROGRAMS, WE WOULD LIKE

4971
03:22:52,720 --> 03:22:53,960
THE ADD TRAINING AND MESSAGING

4972
03:22:53,960 --> 03:22:55,280
TO THEIR OUTREACH PROGRAMS SO

4973
03:22:55,280 --> 03:22:58,360
THEY CAN TALK ABOUT OUR TOPIC

4974
03:22:58,360 --> 03:23:01,720
WHICH IS BRAIN DONATION, TO THE

4975
03:23:01,720 --> 03:23:03,200
PEOPLE THAT THEY ARE ENGAGED

4976
03:23:03,200 --> 03:23:06,680
WITH AND OF COURSE WE WOULD WANT

4977
03:23:06,680 --> 03:23:08,560
THOSE AND IT WILL REQUIRE

4978
03:23:08,560 --> 03:23:09,800
CLINICAL STUDIES THAT WE WORK

4979
03:23:09,800 --> 03:23:12,360
WITH TO REALLY HAVE VERY ACTIVE

4980
03:23:12,360 --> 03:23:13,360
OUTREACH ARMS IN THOSE

4981
03:23:13,360 --> 03:23:14,840
COMMUNITIES. LATINO COMMUNITIES

4982
03:23:14,840 --> 03:23:16,080
AND ASIAN COMMUNITIES NATIVE

4983
03:23:16,080 --> 03:23:20,640
AMERICAN COMMUNITIES, AND THERE

4984
03:23:20,640 --> 03:23:22,720
ARE MANY OTHER COMMUNITIES THAT

4985
03:23:22,720 --> 03:23:24,680
ARE I BELIEVE UNDERREPRESENTED

4986
03:23:24,680 --> 03:23:26,120
BUT THE DATA IS TRICKY TO GET.

4987
03:23:26,120 --> 03:23:27,880
SO THEY ARE TASKED WITH NEED TO

4988
03:23:27,880 --> 03:23:29,400
IDENTIFY BARRIERS TO BRAIN

4989
03:23:29,400 --> 03:23:35,200
DONATION AND TO ALSO EDUCATE US

4990
03:23:35,200 --> 03:23:36,600
ABOUT WHY FOLKS DON'T KNOW ABOUT

4991
03:23:36,600 --> 03:23:39,600
BRAIN DONATION AND WHY FOLKS

4992
03:23:39,600 --> 03:23:41,800
DON'T -- WHY CERTAIN COMMUNITIES

4993
03:23:41,800 --> 03:23:45,600
HESITATE TO DONATE BRAIN. WE

4994
03:23:45,600 --> 03:23:47,720
ALSO WANT TO REACH OUT TO THEM

4995
03:23:47,720 --> 03:23:52,680
AND ESSENTIALLY EDUCATE OR HELP

4996
03:23:52,680 --> 03:23:53,800
COMMUNITIES UNDERSTAND WHY IT IS

4997
03:23:53,800 --> 03:23:54,520
SO IMPORTANT TO THEIR

4998
03:23:54,520 --> 03:23:56,320
COMMUNITIES AND TO THE HEALTH OF

4999
03:23:56,320 --> 03:23:57,920
THEIR COMMUNITIES THAT WE HAVE

5000
03:23:57,920 --> 03:23:59,120
REPRESENTATION FROM THEM IN THE

5001
03:23:59,120 --> 03:24:00,720
BRAIN BANKS. THIS SHOULD HAVE TO

5002
03:24:00,720 --> 03:24:03,960
BE COORDINATED CLOSELY WITH THE

5003
03:24:03,960 --> 03:24:05,400
COMMUNICATIONS CONTRACT WHO THEN

5004
03:24:05,400 --> 03:24:09,000
PROVIDE HAIR MNIZED MESSAGING

5005
03:24:09,000 --> 03:24:10,520
TRAINING, ONE THING TO REACH OUT

5006
03:24:10,520 --> 03:24:12,680
TO COMMUNITIES TO SAY HEY IT IS

5007
03:24:12,680 --> 03:24:14,200
IMPORTANT FOR YOU TO ENROLL IN

5008
03:24:14,200 --> 03:24:17,480
THIS STUDY FOR KIDNEY HEALTH, IT

5009
03:24:17,480 --> 03:24:19,520
IS DIFFERENT TO APPROACH THEM ON

5010
03:24:19,520 --> 03:24:22,200
DONATING A LOVED ONES BRAIN

5011
03:24:22,200 --> 03:24:23,440
AFTER THEY PASS. THERE IS

5012
03:24:23,440 --> 03:24:26,760
MESSAGING AND TRAINING THAT IS

5013
03:24:26,760 --> 03:24:28,080
REQUIRED IN THE COMMUNICATIONS

5014
03:24:28,080 --> 03:24:31,120
CONTRACTOR WILL HELP US DO THAT.

5015
03:24:31,120 --> 03:24:34,440
THEY HELP WITH PRE-REGISTERING

5016
03:24:34,440 --> 03:24:35,880
FOLKS THAT REST INTERESTED IN

5017
03:24:35,880 --> 03:24:36,920
DONATION. AND INTERESTED IN

5018
03:24:36,920 --> 03:24:43,720
LEARNING MOREMENT THE OTHER

5019
03:24:43,720 --> 03:24:45,560
PRONG EFFORT IS TO STRENGTHEN

5020
03:24:45,560 --> 03:24:46,840
COLLABORATION WITH BRAIN BANKS

5021
03:24:46,840 --> 03:24:48,200
AND SITES OF TISSUE COLLECTION.

5022
03:24:48,200 --> 03:24:50,240
THIS WAS SPECIFICALLY A

5023
03:24:50,240 --> 03:24:54,040
RECOMMENDATION FROM THE WORKSHOP

5024
03:24:54,040 --> 03:24:56,480
ON HOW WE CAN GAIN MORE ACCESS

5025
03:24:56,480 --> 03:25:00,880
TO NORMAL OR NEUROTYPICAL

5026
03:25:00,880 --> 03:25:02,520
NON-DISEASE BRAIN. SPECIFIC

5027
03:25:02,520 --> 03:25:07,040
RECOMMENDATIONS THEY HAD WAS TO

5028
03:25:07,040 --> 03:25:07,560
PROVIDE PONDS TO SUPPORT

5029
03:25:07,560 --> 03:25:09,120
CLINICAL STAFF EMBEDDED IN

5030
03:25:09,120 --> 03:25:11,480
MEDICAL EXAMINERS OFFICE AND

5031
03:25:11,480 --> 03:25:13,560
FUNERAL HOMES, HOSPITAL

5032
03:25:13,560 --> 03:25:15,640
AUTOPSIES AND SO ON. TASKED

5033
03:25:15,640 --> 03:25:18,800
WOULD BE TO AID IN DONOR

5034
03:25:18,800 --> 03:25:19,800
PRE-SELECTION EARLY ON TO

5035
03:25:19,800 --> 03:25:22,760
LIAISON WITH FAMILIES, INFORMED

5036
03:25:22,760 --> 03:25:24,040
CONCEPT AND PROVIDE INFORMATION

5037
03:25:24,040 --> 03:25:25,760
THEY NEED ON THE DONATION

5038
03:25:25,760 --> 03:25:28,520
PROCESS AND ALSO LIAISON WITH

5039
03:25:28,520 --> 03:25:33,040
THE BANK, TO HAND OFF TISSUE AND

5040
03:25:33,040 --> 03:25:34,920
RETURN TO FOR EXAMPLE MEDICAL

5041
03:25:34,920 --> 03:25:35,920
EXAMINERS OFFICE WHAT IS

5042
03:25:35,920 --> 03:25:37,520
IMPORTANT TO THEM AND THAT IS

5043
03:25:37,520 --> 03:25:40,200
THE NEUROPATHOLOGICAL REPORT. 

5044
03:25:40,200 --> 03:25:41,840
PART OF THE EFFORT WOULD INCLUDE

5045
03:25:41,840 --> 03:25:42,960
COMMUNITY OUTREACH ENGAGEMENT

5046
03:25:42,960 --> 03:25:45,160
BECAUSE THESE WOULD BE VERY

5047
03:25:45,160 --> 03:25:47,880
LOCAL EFFORTS, IF IT IS MEDICAL

5048
03:25:47,880 --> 03:25:49,880
EXAMINERS OFFICE AND ACCOUNTING,

5049
03:25:49,880 --> 03:25:51,880
IT WOULD BE EXTREMELY IMPORTANT

5050
03:25:51,880 --> 03:25:53,080
FOR THOSE THAT SHOW UP IN THAT

5051
03:25:53,080 --> 03:25:55,040
OFFICE HAVE SOME PRIOR KNOWLEDGE

5052
03:25:55,040 --> 03:25:59,040
OF BRAIN DONATION AND WHY IT IS

5053
03:25:59,040 --> 03:26:00,400
IMPORTANT. IF POSSIBLE WE LIKE

5054
03:26:00,400 --> 03:26:02,880
TO MAKE EFFORTS TO TARGET IDEA

5055
03:26:02,880 --> 03:26:06,320
STATES AND MINORITY SERVING

5056
03:26:06,320 --> 03:26:07,400
INSTITUTIONS.

5057
03:26:07,400 --> 03:26:07,880
>> CLOSE TO WRAPPING UP?

5058
03:26:07,880 --> 03:26:09,120
>> I'M DONE. I WAS GOING
TO SAY

5059
03:26:09,120 --> 03:26:11,520
THANK YOU AND TAKE QUESTIONS. 

5060
03:26:11,520 --> 03:26:14,120
>> OKAY. ANY QUESTIONS
ABOUT

5061
03:26:14,120 --> 03:26:15,520
THIS FOR DAN? THANKS A LOT. 

5062
03:26:15,520 --> 03:26:26,000
GREAT JOB. OKAY. WANT TO MAKE

5063
03:26:26,600 --> 03:26:30,840
SURE THERE'S NO QUESTIONS. IN

5064
03:26:30,840 --> 03:26:31,200
THAT CASE --

5065
03:26:31,200 --> 03:26:34,080
>> THERE WAS A POINT ABOUT

5066
03:26:34,080 --> 03:26:35,680
APPROACHING PALLIATIVE TEAMS,

5067
03:26:35,680 --> 03:26:37,640
DID YOU MENTION THAT?

5068
03:26:37,640 --> 03:26:40,040
>> I DID NOT.  COULD YOU

5069
03:26:40,040 --> 03:26:40,360
ELABORATE?

5070
03:26:40,360 --> 03:26:44,120
>> IT WAS IN THE CHAT. IT
WASN'T

5071
03:26:44,120 --> 03:26:44,320
FROM ME.

5072
03:26:44,320 --> 03:26:46,200
>> IT WAS FROM ME, JUST
CURIOUS

5073
03:26:46,200 --> 03:26:48,360
LOOKING AT COLLABORATIVE

5074
03:26:48,360 --> 03:26:49,680
PARTNERS IF YOU THOUGHT ABOUT

5075
03:26:49,680 --> 03:26:52,800
REACHING OUT TO PALLIATIVE CARE

5076
03:26:52,800 --> 03:26:54,400
TEAMS, TYPICALLY ALREADY ENGAGED

5077
03:26:54,400 --> 03:26:57,000
IN SENSITIVE CONVERSATION. MIGHT

5078
03:26:57,000 --> 03:26:59,600
BE A NATURAL PARTNER.

5079
03:26:59,600 --> 03:27:02,360
>> GREAT POINT. THANK YOU.

5080
03:27:02,360 --> 03:27:04,320
>> OKAY. AT THIS POINT IT
WOULD

5081
03:27:04,320 --> 03:27:06,640
BE GREAT TO HAVE A MOTION TO

5082
03:27:06,640 --> 03:27:08,040
APPROVE OR DISAPPROVE THIS

5083
03:27:08,040 --> 03:27:14,600
PARTICULAR IDEA.

5084
03:27:14,600 --> 03:27:18,080
>> SO MOVED.

5085
03:27:18,080 --> 03:27:20,280
>> SECOND. OKAY. YOU CAN
GO TO

5086
03:27:20,280 --> 03:27:25,000
THE CHAT AND THANKS AGAIN, DAN.

5087
03:27:25,000 --> 03:27:27,400
CAN SOMEBODY PUT UP MY SLIDE AND

5088
03:27:27,400 --> 03:27:28,960
MISCELLANEOUS INITIATIVES?

5089
03:27:28,960 --> 03:27:30,280
>> THIS SLIDE WHICH YOU
ARE

5090
03:27:30,280 --> 03:27:32,840
ABOUT TO SEE MOSTLY CONSISTS OF

5091
03:27:32,840 --> 03:27:35,600
REISSUES OF EXISTING INITIATIVES

5092
03:27:35,600 --> 03:27:37,240
THAT WE WERE INCLINED TO TALK

5093
03:27:37,240 --> 03:27:38,760
ABOUT UNLESS YOU HAVE QUESTIONS.

5094
03:27:38,760 --> 03:27:41,840
I SEE THAT OUR SPEAKERS AND

5095
03:27:41,840 --> 03:27:43,320
PARTICIPANTS FOR THE LAST

5096
03:27:43,320 --> 03:27:47,880
SEGMENT OF COUNCIL ARE NOW ON.

5097
03:27:47,880 --> 03:27:53,760
THE INITIATIVE? GREAT. OKAY. IF

5098
03:27:53,760 --> 03:27:56,680
YOU LOOK AT THIS NUMBERS FOUR

5099
03:27:56,680 --> 03:27:57,880
THROUGH 9 ESSENTIALLY REISSUES

5100
03:27:57,880 --> 03:28:02,160
OF EXISTING INITIATIVES. JUST

5101
03:28:02,160 --> 03:28:02,680
SAY IMBIBINGLY THIS FIRST

5102
03:28:02,680 --> 03:28:03,880
COUNTER ACT INITIATIVE, THIS IS

5103
03:28:03,880 --> 03:28:05,840
USING DEDICATED STREAM OF

5104
03:28:05,840 --> 03:28:11,440
COUNTER ACT MONEY IS MORE T POO

5105
03:28:11,440 --> 03:28:13,520
FOCUSED ON EARLY FACE PHASES OF

5106
03:28:13,520 --> 03:28:16,320
CHEMICAL THREATS. IF YOU READ

5107
03:28:16,320 --> 03:28:18,720
THE MISSION THAT SPRIGGS WROTE,

5108
03:28:18,720 --> 03:28:20,240
TO UNDERSTAND THE FUNDAMENTAL

5109
03:28:20,240 --> 03:28:22,280
MECHANISMS OF TOXICITY OF

5110
03:28:22,280 --> 03:28:23,280
CHEMICAL -- IN THE SUPPORT

5111
03:28:23,280 --> 03:28:24,520
RESEARCH DEVELOPMENT OF

5112
03:28:24,520 --> 03:28:27,400
THERAPEUTICS THAT REDUCE

5113
03:28:27,400 --> 03:28:28,240
MORTALITY AND MORBIDITY IN THE

5114
03:28:28,240 --> 03:28:29,680
EVENT OF THE RELEASE OF THESE

5115
03:28:29,680 --> 03:28:31,120
KINDS OF -- SO THIS IS FOCUSING

5116
03:28:31,120 --> 03:28:32,480
PARTICULARLY ON THE EARLY PHASE

5117
03:28:32,480 --> 03:28:34,800
OF THAT PROCESS WHICH IS A

5118
03:28:34,800 --> 03:28:39,160
LITTLE UNDERFOCUSED ON. THE NEXT

5119
03:28:39,160 --> 03:28:40,920
INITIATIVE HALFWAY DOWN IS EARLY

5120
03:28:40,920 --> 03:28:42,360
STAGE ESTABLISHED BIOMEDICAL

5121
03:28:42,360 --> 03:28:44,960
DATA REPOSITORIES OR KNOWLEDGE

5122
03:28:44,960 --> 03:28:47,680
BASES, AND ESSENTIALLY THIS IS

5123
03:28:47,680 --> 03:28:49,880
TWO COMPANION IF I RECALL TWO

5124
03:28:49,880 --> 03:28:52,480
COMPANION FUNDING ANNOUNCEMENTS,

5125
03:28:52,480 --> 03:28:54,880
ONE FOR NEW OR EARLY STAGE

5126
03:28:54,880 --> 03:28:56,960
BIOREPOSITORIES AND OTHER ONE

5127
03:28:56,960 --> 03:28:58,920
FOR EXISTING BIOREPOSITORIES OR

5128
03:28:58,920 --> 03:29:01,000
KNOWLEDGE BASES. THIS CONCEPT

5129
03:29:01,000 --> 03:29:05,280
WAS APPROVED BY TRANS-NIH

5130
03:29:05,280 --> 03:29:06,120
COUNCILS BACK IN JANUARY AND

5131
03:29:06,120 --> 03:29:08,400
WHAT WE WANT TO DO IS SIGN ON TO

5132
03:29:08,400 --> 03:29:11,640
THIS. THE IDEA IS TO MAKE SURE

5133
03:29:11,640 --> 03:29:12,920
THERE ARE HIGH QUALITY DATABASES

5134
03:29:12,920 --> 03:29:16,320
THAT ALLOW THE SHARING OF

5135
03:29:16,320 --> 03:29:19,240
REAGENTS AND KNOWLEDGE WE TALKED

5136
03:29:19,240 --> 03:29:20,720
ABOUT EARLIER. SO THAT IS PRETTY

5137
03:29:20,720 --> 03:29:22,560
MUCH IT FOR THAT ONE. THE THIRD

5138
03:29:22,560 --> 03:29:25,280
ONE IS PART OF THE AMPD PROJECT

5139
03:29:25,280 --> 03:29:26,480
THAT I THINK MOST OF YOU KNOW

5140
03:29:26,480 --> 03:29:29,040
WHAT THAT IS. IT IS ESSENTIALLY

5141
03:29:29,040 --> 03:29:31,560
A COLLABORATION BETWEEN NINDS

5142
03:29:31,560 --> 03:29:33,320
AND INDUSTRY FOCUSED ON

5143
03:29:33,320 --> 03:29:35,080
PARKINSON DISEASE, THE GOAL HERE

5144
03:29:35,080 --> 03:29:38,160
IS TO TAKE EXTRA CELLULAR

5145
03:29:38,160 --> 03:29:39,680
VESICALES, PLEASE JUMP IN IF I

5146
03:29:39,680 --> 03:29:41,880
GET THIS WRONG, AND TO SEQUENCE

5147
03:29:41,880 --> 03:29:44,320
THE RNA FROM THEM IN ORDER TO

5148
03:29:44,320 --> 03:29:47,320
GET COMPREHENSIVE RESOURCE OF

5149
03:29:47,320 --> 03:29:50,240
RNA SEQUENCING DATA FROM PEOPLE

5150
03:29:50,240 --> 03:29:52,720
WITH PARKINSON AND NORMAL

5151
03:29:52,720 --> 03:29:55,240
CONTROLS. ALL THESE PEOPLE WHO

5152
03:29:55,240 --> 03:29:57,200
ARE BEING WHOSE DNA RNA

5153
03:29:57,200 --> 03:29:59,720
SEQUENCED WE CURRENTLY HAVE

5154
03:29:59,720 --> 03:30:01,920
WHOLE GENOMIC TRANSCRIPTOMIC AND

5155
03:30:01,920 --> 03:30:02,920
PROTEOMIC SEQUENCING AVAILABLE

5156
03:30:02,920 --> 03:30:04,520
DATA ON THEM. SO THIS IS

5157
03:30:04,520 --> 03:30:06,240
INTENDED TO COMPLIMENT THAT.

5158
03:30:06,240 --> 03:30:09,840
TAKE IT A STEP FURTHER. THOSE

5159
03:30:09,840 --> 03:30:13,480
ARE THE THREE NEWISH INITIATIVES

5160
03:30:13,480 --> 03:30:16,920
THE REST YOU CAN SEE HERE IS AN

5161
03:30:16,920 --> 03:30:19,200
INITIATIVE ABOUT FOR RO1s FOR

5162
03:30:19,200 --> 03:30:22,400
NEW AT RISK INVESTIGATORS, THIS

5163
03:30:22,400 --> 03:30:24,040
IS WHAT WALTER TALKED ABOUT IN

5164
03:30:24,040 --> 03:30:25,760
DIRECTIVES TALK.  THE REST,

5165
03:30:25,760 --> 03:30:29,400
THESE ARISH ISSUE OF BRAIN AND

5166
03:30:29,400 --> 03:30:31,280
HEAL INITIATIVES THAT YOU SAW IN

5167
03:30:31,280 --> 03:30:32,600
THE PAST. THIS CONTRACT WE ARE

5168
03:30:32,600 --> 03:30:36,240
LOOKING TO RENEW. ANY PRESSING

5169
03:30:36,240 --> 03:30:40,720
QUESTIONS, AARON?

5170
03:30:40,720 --> 03:30:44,680
>> NUMBER 3 I WAS
WONDERING WHAT

5171
03:30:44,680 --> 03:30:47,000
IS THE PLAN FOR CELL OR TISSUE

5172
03:30:47,000 --> 03:30:49,200
TYPE? WHAT WILL BE SEQUENCED?

5173
03:30:49,200 --> 03:30:52,240
WHERE IS THE RNA COMING FROM?

5174
03:30:52,240 --> 03:30:54,360
>> I TOLD YOU IT IS EXTRA

5175
03:30:54,360 --> 03:30:57,200
CELLULAR VESICLES BUT IN TERMS

5176
03:30:57,200 --> 03:31:02,480
OF TISSUE -- I GUESS THIS IS DEB

5177
03:31:02,480 --> 03:31:03,280
BABBCOCK. DO YOU WANT THE TALK

5178
03:31:03,280 --> 03:31:03,640
ABOUT THAT?

5179
03:31:03,640 --> 03:31:07,960
>> I CAN ANSWER THAT
QUESTION. 

5180
03:31:07,960 --> 03:31:10,080
THANK YOU. SO THIS IS BASED ON A

5181
03:31:10,080 --> 03:31:13,120
PILOT PROJECT THAT BRAND WHERE

5182
03:31:13,120 --> 03:31:15,880
WE LOOK AT EXTRA CELLULAR

5183
03:31:15,880 --> 03:31:19,120
VESICLES IN BLOOD AND CSF. THE

5184
03:31:19,120 --> 03:31:21,360
YIELD WAS SO LOW IN CSF THE

5185
03:31:21,360 --> 03:31:24,200
COMMITTEE WANTED TO GO AHEAD AND

5186
03:31:24,200 --> 03:31:27,480
DO IT IN BLOCK. AS BOB MENTIONED

5187
03:31:27,480 --> 03:31:29,160
WE HAVE WHOLE GENOME SEQUENCING

5188
03:31:29,160 --> 03:31:31,560
AND PROTEOMICS AND

5189
03:31:31,560 --> 03:31:32,840
TRANSCRIPTOMICS IN BLOOD.  THIS

5190
03:31:32,840 --> 03:31:35,880
IS A NICE COMPANION TO THE

5191
03:31:35,880 --> 03:31:38,680
EXISTING SEQUENCES BECAUSE EXTRA

5192
03:31:38,680 --> 03:31:40,400
CELLULAR VESICALES ACROSS THE

5193
03:31:40,400 --> 03:31:42,040
BLOOD BRAIN -- CROSS THE BLOOD

5194
03:31:42,040 --> 03:31:45,680
BRAIN BARRIER.

5195
03:31:45,680 --> 03:31:50,760
>> SO IS THE IDEA THAT THE
RNA

5196
03:31:50,760 --> 03:31:52,360
IN THESE VESICALES WILL SOMEHOW

5197
03:31:52,360 --> 03:31:55,440
CONTRIBUTE TO THE DISEASE? I'M

5198
03:31:55,440 --> 03:31:57,400
WONDERING WHAT WAS LEARNED FROM

5199
03:31:57,400 --> 03:31:58,600
THE GENOME SEQUENCING OF BLOOD

5200
03:31:58,600 --> 03:31:59,880
AND THE RNA SEQUENCING OF

5201
03:31:59,880 --> 03:32:03,320
PROTEOMICS AND BLOOD SO FAR.

5202
03:32:03,320 --> 03:32:08,400
>> RIGHT NOW IT IS ALL
BEING

5203
03:32:08,400 --> 03:32:11,760
USED TO IDENTIFY BIOMARKERS.

5204
03:32:11,760 --> 03:32:13,000
THAT WAS THE OVERARCHING GOAL OF

5205
03:32:13,000 --> 03:32:15,360
THE PROJECT. WE HAVE HAD A

5206
03:32:15,360 --> 03:32:20,640
NUMBER OF BIOMARKER PROJECTS

5207
03:32:20,640 --> 03:32:23,880
PUBLISHED AND WE HAVE HAD A

5208
03:32:23,880 --> 03:32:27,880
NUMBER OF GENES AND TRANSCRIPTS

5209
03:32:27,880 --> 03:32:30,880
IDENTIFIED THAT ARE NEW FOR

5210
03:32:30,880 --> 03:32:34,040
PARKINSON'S DISEASE. WHAT WE ARE

5211
03:32:34,040 --> 03:32:36,240
INTERESTED IN IS TRYING TO GET

5212
03:32:36,240 --> 03:32:38,880
SOMETHING THAT IS A LITTLE MORE

5213
03:32:38,880 --> 03:32:40,480
REPRESENTATIVE OF WHAT IS GOING

5214
03:32:40,480 --> 03:32:43,080
ON IN THE BRAIN. WE ARE GOING TO

5215
03:32:43,080 --> 03:32:45,640
BE DOING A PILOT PROJECT ON --

5216
03:32:45,640 --> 03:32:47,880
WE ARE IN FACT CURRENTLY DOING A

5217
03:32:47,880 --> 03:32:49,920
PILOT PROJECT ON SINGLE NUCLEUS

5218
03:32:49,920 --> 03:32:52,800
RNA SEQUENCING AND BRAIN TISSUE

5219
03:32:52,800 --> 03:32:54,080
AND WHOLE GENOME SEQUENCING IN

5220
03:32:54,080 --> 03:32:57,040
BRAIN TISSUE. WE ARE TRYING TO

5221
03:32:57,040 --> 03:33:00,680
SEE IF THERE IS -- IF THE -- IF

5222
03:33:00,680 --> 03:33:05,080
THE EXTRA CELLULAR VESICALES CAN

5223
03:33:05,080 --> 03:33:07,560
BE A BRIDGE INSTEAD OF HAVING TO

5224
03:33:07,560 --> 03:33:09,440
OBVIOUSLY WE DON'T DO BRAIN

5225
03:33:09,440 --> 03:33:13,120
BIOPSIES IN PEOPLE. SO I THINK

5226
03:33:13,120 --> 03:33:15,200
ALL OF THESE SAMPLES ARE

5227
03:33:15,200 --> 03:33:17,680
SEQUENCED LONGITUDINALLY EXCEPT

5228
03:33:17,680 --> 03:33:19,520
WHOLE GENOME SEQUENCING BUT THE

5229
03:33:19,520 --> 03:33:22,320
OTHER ONES SEQUENCED

5230
03:33:22,320 --> 03:33:24,120
LONGITUDINALLY SO OUR HOPE IS TO

5231
03:33:24,120 --> 03:33:27,480
BE ABLE TO GET A CLEAR PICTURE

5232
03:33:27,480 --> 03:33:28,800
OF DISEASE PROGRESSION. . WHAT

5233
03:33:28,800 --> 03:33:30,560
IS CHANGING IN THE TRANSCRIPTS,

5234
03:33:30,560 --> 03:33:34,800
WHAT IS CHANGING IN THE PROTEINS

5235
03:33:34,800 --> 03:33:38,560
AS THE DISEASE WORSENS. 

5236
03:33:38,560 --> 03:33:40,440
>> ARE THERE NEURONAL

5237
03:33:40,440 --> 03:33:42,240
TRANSCRIPTS PRESENT IN THE EXTRA

5238
03:33:42,240 --> 03:33:46,120
CELLULAR VESICLES FROM BLOOD?

5239
03:33:46,120 --> 03:33:47,840
>> WE MIGHT TAKE THIS
UNLESS

5240
03:33:47,840 --> 03:33:51,280
INTRINSIC TO YOUR APPROVING OR

5241
03:33:51,280 --> 03:33:53,720
DISAPPROVING.

5242
03:33:53,720 --> 03:33:56,520
>> DEFINITELY, IT IS
EXTREMELY

5243
03:33:56,520 --> 03:34:02,520
INTERESTING, FEEL FREE TO EMAIL

5244
03:34:02,520 --> 03:34:05,560
THEM WE HAVE PRELIMINARY DATA

5245
03:34:05,560 --> 03:34:09,960
THAT I'M HAPPY TO SHARE ON WHAT

5246
03:34:09,960 --> 03:34:13,160
-- BLOOD IN THE CSF. 

5247
03:34:13,160 --> 03:34:17,680
>> YES. OKAY. IF THERE ARE
NO

5248
03:34:17,680 --> 03:34:18,880
OTHER QUESTIONS, I WILL PAUSE

5249
03:34:18,880 --> 03:34:20,840
FOR A SECOND. I NEED A MOTION

5250
03:34:20,840 --> 03:34:22,720
FOR THIS GROUP OF NINE

5251
03:34:22,720 --> 03:34:26,080
INITIATIVE CONCEPTS.  I SEE A

5252
03:34:26,080 --> 03:34:31,440
MOTION FROM GENE NET AND SECOND

5253
03:34:31,440 --> 03:34:33,120
FROM TIM. EMPTY YOUR VOTES IN

5254
03:34:33,120 --> 03:34:35,600
THE CHAT.  SORRY WE WERE SO

5255
03:34:35,600 --> 03:34:43,240
RUSHED TODAY.  THERE IS AN ECHO.

5256
03:34:43,240 --> 03:34:46,200
THE VERY LAST THING ON THE

5257
03:34:46,200 --> 03:34:47,480
AGENDA IS AN IMPORTANT

5258
03:34:47,480 --> 03:34:49,320
DISCUSSION OF OPEN ACCESS

5259
03:34:49,320 --> 03:34:51,680
PUBLISHING OR PERHAPS THE WHOLE

5260
03:34:51,680 --> 03:34:53,880
MORE GENERAL OPEN ACCESS

5261
03:34:53,880 --> 03:34:55,520
ENVIRONMENT CONCEPT. TIM RYAN

5262
03:34:55,520 --> 03:34:56,760
PROPOSED THAT WE HAVE THIS

5263
03:34:56,760 --> 03:34:58,480
DISCUSSION, SOMETHING LIKE A

5264
03:34:58,480 --> 03:35:01,440
YEAR AGO AND WE DECIDED TO

5265
03:35:01,440 --> 03:35:02,560
POSTPONE IT WHILE WE FIGURED

5266
03:35:02,560 --> 03:35:03,920
WHAT THE LANDSCAPE AROUND OPEN

5267
03:35:03,920 --> 03:35:06,640
ACCESS WAS AT NIH AND HHS. WHICH

5268
03:35:06,640 --> 03:35:08,280
PERHAPS OUR FIRST SPEAKER CAN

5269
03:35:08,280 --> 03:35:10,560
TALK ABOUT. SO IN ANY CASE I

5270
03:35:10,560 --> 03:35:13,760
WILL PASS IT TO AMY ADAMS WHO IS

5271
03:35:13,760 --> 03:35:16,680
THE NINDS DEPUTY DIRECTOR FOR

5272
03:35:16,680 --> 03:35:18,600
SCIENCE MANAGEMENT AND

5273
03:35:18,600 --> 03:35:19,280
OPERATIONS AND SHE WILL

5274
03:35:19,280 --> 03:35:22,360
INTRODUCE THE SPEAKERS. WE WILL

5275
03:35:22,360 --> 03:35:25,640
-- I'M CERTAIN WE WILL PASS THE

5276
03:35:25,640 --> 03:35:27,080
TENTATIVE 5:45 TIME, I IMAGINE

5277
03:35:27,080 --> 03:35:32,400
WE WILL GO TO ABOUT SIX O'CLOCK

5278
03:35:32,400 --> 03:35:34,320
FOR THOSE THAT NEED TO MAKE

5279
03:35:34,320 --> 03:35:34,520
PLANS.

5280
03:35:34,520 --> 03:35:36,200
>> THANK YOU SO MUCH, BOB.
I'M

5281
03:35:36,200 --> 03:35:38,360
GOING TO TAKE A MINUTE OR TWO TO

5282
03:35:38,360 --> 03:35:39,800
FRAME THIS DISCUSSION. AND THEN

5283
03:35:39,800 --> 03:35:41,760
I'M VERY EXCITED TO INTRODUCE

5284
03:35:41,760 --> 03:35:45,360
OUR SPEAKERS. SO AS WE LIKE TO

5285
03:35:45,360 --> 03:35:47,080
SAY THAT SCIENCE ISN'T FINISHED

5286
03:35:47,080 --> 03:35:48,880
UNTIL IT IS COMMUNICATED BUT THE

5287
03:35:48,880 --> 03:35:50,520
QUESTION HOW TO SHARE SCIENTIFIC

5288
03:35:50,520 --> 03:35:52,320
RESULTS SO THEY PROVIDE THE MOST

5289
03:35:52,320 --> 03:35:53,960
BENEFIT AND ADVANCE KNOWLEDGE

5290
03:35:53,960 --> 03:35:55,960
MOST EFFECTIVELY HAS BEEN AN

5291
03:35:55,960 --> 03:35:59,840
ACTIVE AREA OF DEBATE FOR

5292
03:35:59,840 --> 03:36:02,280
DECADES. THERE ARE ARGUMENTS

5293
03:36:02,280 --> 03:36:05,960
THAT OPEN ACCESS WHICH REFERS TO

5294
03:36:05,960 --> 03:36:07,480
POLICY ENSURING RESEARCH

5295
03:36:07,480 --> 03:36:08,880
LITERATURE IS DIGITAL ONLINE

5296
03:36:08,880 --> 03:36:10,720
FREE OF CHARGE AND FREE OF MOST

5297
03:36:10,720 --> 03:36:12,160
COPYRIGHT AND LICENSING

5298
03:36:12,160 --> 03:36:13,480
RESTRICTIONS, IS THE BEST

5299
03:36:13,480 --> 03:36:15,560
APPROACH. MANY OF THOSE

5300
03:36:15,560 --> 03:36:16,800
RESTRICTIONS ACTUALLY ARE

5301
03:36:16,800 --> 03:36:18,480
CRITICAL FOR SUPPORTING

5302
03:36:18,480 --> 03:36:19,560
INFRASTRUCTURE FOR CURRENT

5303
03:36:19,560 --> 03:36:20,560
MODELS OF PUBLISHING AND PEER

5304
03:36:20,560 --> 03:36:24,160
REVIEW.  JUST TO TAKE AN NIH

5305
03:36:24,160 --> 03:36:27,320
LENS TO THIS AS WE ARE ADVISORY

5306
03:36:27,320 --> 03:36:29,120
COUNCIL OF NIH AS MANY OF YOU

5307
03:36:29,120 --> 03:36:31,960
KNOW IN 2008 NIH PUBLIC ACCESS

5308
03:36:31,960 --> 03:36:33,600
POLICY WENT INTO EFFECT AND IN

5309
03:36:33,600 --> 03:36:35,560
2013 THE WHITE HOUSE OFFICE OF

5310
03:36:35,560 --> 03:36:36,360
SCIENCE AND TECHNOLOGY POLICY

5311
03:36:36,360 --> 03:36:40,200
ISSUED A POLICY MEMORANDUM AT

5312
03:36:40,200 --> 03:36:43,720
MOST FEDERAL AGENCIES MAKING

5313
03:36:43,720 --> 03:36:45,320
THEM MAKE SURE THAT PUBLICATIONS

5314
03:36:45,320 --> 03:36:47,120
AND DATA RESULTING FROM FUNDED

5315
03:36:47,120 --> 03:36:50,160
-- FEDERALLY FUNDED RESEARCH WAS

5316
03:36:50,160 --> 03:36:51,680
FREELY AVAILABLE TO THE PUBLIC

5317
03:36:51,680 --> 03:36:53,360
WITHIN ONE YEAR OF PUBLICATION. 

5318
03:36:53,360 --> 03:36:54,920
SINCE THEN THERE'S EXPANSION OF

5319
03:36:54,920 --> 03:36:56,240
ONLINE PUBLISHING CONTINUED

5320
03:36:56,240 --> 03:36:57,920
EXPERIMENTS AND PUBLISHING AND

5321
03:36:57,920 --> 03:37:00,120
PRE-PUBLISHING ALONG WITH RECENT

5322
03:37:00,120 --> 03:37:04,480
POLICY CHANGES BY MAJOR FUNDERS

5323
03:37:04,480 --> 03:37:05,880
AND WE HAD THE EXPERIENCE OVER

5324
03:37:05,880 --> 03:37:06,960
TWO YEARS URGENT IMMEDIATE NEED

5325
03:37:06,960 --> 03:37:10,200
FOR ACCESS TO DATA RELATING TO

5326
03:37:10,200 --> 03:37:12,240
COVID-19. THESE ARE A FEW

5327
03:37:12,240 --> 03:37:13,800
EXAMPLES OF THIS THAT RAISE THE

5328
03:37:13,800 --> 03:37:15,440
QUESTION FOR US WHAT IS THE

5329
03:37:15,440 --> 03:37:19,080
RIGHT ACCESS POLICY FOR NIH AND

5330
03:37:19,080 --> 03:37:20,640
HOW CAN NINDS NEUROSCIENCE

5331
03:37:20,640 --> 03:37:22,400
COMMUNITY ACT TO ENSURE

5332
03:37:22,400 --> 03:37:22,880
SCIENTIFIC RESULTS ARE

5333
03:37:22,880 --> 03:37:25,320
DISSEMINATED.  SO TODAY WE

5334
03:37:25,320 --> 03:37:26,360
BROUGHT TOGETHER A NUMBER OF

5335
03:37:26,360 --> 03:37:28,920
DIFFERENT PERSPECTIVES FROM THE

5336
03:37:28,920 --> 03:37:30,960
NIH FROM THE SCIENTIFIC

5337
03:37:30,960 --> 03:37:32,000
PUBLISHING WORLD AND DIFFERENT

5338
03:37:32,000 --> 03:37:35,880
NON-FEDERAL FUNDING AGENCIES,

5339
03:37:35,880 --> 03:37:38,440
HMHMI AND ASAP TO DISCUSS

5340
03:37:38,440 --> 03:37:39,880
EXPERIENCING WITH THE EVOLVING

5341
03:37:39,880 --> 03:37:42,200
LANDSCAPE AROUND OPEN ACCESS TO

5342
03:37:42,200 --> 03:37:43,600
GATHER IDEAS PERSPECTIVES AN

5343
03:37:43,600 --> 03:37:47,760
FEEDBACK TO SHARE WITH NIH AS IT

5344
03:37:47,760 --> 03:37:49,760
CONSIDERS IF POSSIBLY HOW IT

5345
03:37:49,760 --> 03:37:50,880
MIGHT SHIFT ITS OWN POLICIES. 

5346
03:37:50,880 --> 03:37:54,720
WE ARE NOT SAYING MINI NIH IS

5347
03:37:54,720 --> 03:37:56,080
PLANNING ANY JUST GATHERING

5348
03:37:56,080 --> 03:37:57,040
POINTS TO CONSIDER TO INFORM

5349
03:37:57,040 --> 03:38:01,800
THAT DISCUSSION.  SO LOOK

5350
03:38:01,800 --> 03:38:03,080
FORWARD TOKER THATTING FROM THEM

5351
03:38:03,080 --> 03:38:04,240
AND FROM YOU. WE ARE GOING TO

5352
03:38:04,240 --> 03:38:05,600
TRY TO MAXIMIZE THE TIME FOR

5353
03:38:05,600 --> 03:38:07,480
FULL DISCUSSION SO WE REALLY ASK

5354
03:38:07,480 --> 03:38:09,400
THAT AFTER EACH SPEAKER PLEASE

5355
03:38:09,400 --> 03:38:12,280
FEEL FREE TO ASK ANY CLARIFYING

5356
03:38:12,280 --> 03:38:14,480
QUESTIONS BUT SAVE YOUR

5357
03:38:14,480 --> 03:38:16,840
DISCUSSION QUESTIONS FOR AFTER

5358
03:38:16,840 --> 03:38:21,200
THE LAST SPEAKER:  SO WITH THAT,

5359
03:38:21,200 --> 03:38:23,480
I WILL START BY INTRODUCING OUR

5360
03:38:23,480 --> 03:38:24,760
FIRST SPEAKER WHO I SEE ON OUR

5361
03:38:24,760 --> 03:38:26,520
SCREEN, TERRIFIC. SO IT IS WITH

5362
03:38:26,520 --> 03:38:27,760
TREMENDOUS PLEASURE THAT I

5363
03:38:27,760 --> 03:38:29,360
INTRODUCE JERRY SHEEHAN, DEPUTY

5364
03:38:29,360 --> 03:38:30,360
DIRECTOR FOR THE NATIONAL

5365
03:38:30,360 --> 03:38:33,440
LIBRARY OF MEDICINE HE HAS

5366
03:38:33,440 --> 03:38:36,600
SERVED DEPUTY DIRECTOR OF NLM

5367
03:38:36,600 --> 03:38:38,640
SINCE 2017, BEFORE THAT IN THE

5368
03:38:38,640 --> 03:38:40,960
ROLE OF ASSISTANT DIRECTOR FOR

5369
03:38:40,960 --> 03:38:42,760
POLICY DEVELOPMENT AND NLM, HE

5370
03:38:42,760 --> 03:38:45,640
WAS IN THAT ROLE FROM 2006. 

5371
03:38:45,640 --> 03:38:47,360
DURING THAT PERIOD HE HAS TWICE

5372
03:38:47,360 --> 03:38:49,960
SERVED ON EXTENDED DETAIL WHITE

5373
03:38:49,960 --> 03:38:52,000
HOUSE OFFICE OF SCIENCE AND

5374
03:38:52,000 --> 03:38:53,040
TECHNOLOGY POTSY WHERE HE WORKS

5375
03:38:53,040 --> 03:38:54,600
TO ADVANCE OPEN SCIENCE POLICIES

5376
03:38:54,600 --> 03:38:57,920
ACROSS THE FEDERAL GOVERNMENT. 

5377
03:38:57,920 --> 03:38:59,720
HERE AT NIH HE PLAY AD PIVOTAL

5378
03:38:59,720 --> 03:39:00,520
ROLE IN FORMULATION AND

5379
03:39:00,520 --> 03:39:02,480
IMPLEMENTATION OF NUMEROUS NIH

5380
03:39:02,480 --> 03:39:04,600
LEVEL POLICIES, RELATED TO

5381
03:39:04,600 --> 03:39:05,760
SCIENTIFIC GENOMIC DATA SHARING

5382
03:39:05,760 --> 03:39:07,560
AS WELL AS PUBLIC ACCESS TOLL

5383
03:39:07,560 --> 03:39:10,240
NIH FUNDED PUBLICATIONS.  WE ARE

5384
03:39:10,240 --> 03:39:11,600
LOOKING FORWARD TO HEARING FROM

5385
03:39:11,600 --> 03:39:12,960
YOU JERRY.  PLEASE FEEL FREE.

5386
03:39:12,960 --> 03:39:16,600
>> I WILL SAY ONE QUICK
THING,

5387
03:39:16,600 --> 03:39:18,240
WHEN I PUT DOWN THE LIST OF

5388
03:39:18,240 --> 03:39:20,800
SPEAKERS ON AGENDA, I PUT

5389
03:39:20,800 --> 03:39:22,960
OUTSIDE SPEAKERS BUT OUR COUNCIL

5390
03:39:22,960 --> 03:39:24,600
MEMBER HAS A REAL STAKE IN THIS

5391
03:39:24,600 --> 03:39:27,880
WHOLE ISSUE. YOU WILL HEAR MORE

5392
03:39:27,880 --> 03:39:30,200
ABOUT THAT SOON.  HI JERRY,

5393
03:39:30,200 --> 03:39:32,120
SORRY TO INTERRUPT.

5394
03:39:32,120 --> 03:39:37,080
>> AMY, CAN YOU HEAR ME
OKAY?

5395
03:39:37,080 --> 03:39:38,440
USUALLY A DIFFERENT MICROPHONE

5396
03:39:38,440 --> 03:39:39,600
SET UP TODAY.

5397
03:39:39,600 --> 03:39:40,240
>> LOUD AND CLEAR.

5398
03:39:40,240 --> 03:39:44,000
>> I'M GLAD IT IS WORKING.

5399
03:39:44,000 --> 03:39:45,720
>> THANK YOU FOR INVITING
ME TO

5400
03:39:45,720 --> 03:39:49,680
SPEAK TO YOUR COUNCIL TODAY.  AS

5401
03:39:49,680 --> 03:39:51,480
DEPUTY DIRECTOR PART OF NIH THAT

5402
03:39:51,480 --> 03:39:53,560
HAS THE EXPLICIT MISSION OF

5403
03:39:53,560 --> 03:39:55,960
COLLECTING ORGANIZING AND

5404
03:39:55,960 --> 03:39:58,640
DISSEMINATING INFORMATION NIH

5405
03:39:58,640 --> 03:40:03,920
PUBLIC ACCESS POLICY ARE AREA OF

5406
03:40:03,920 --> 03:40:05,120
GREAT INTEREST AND WE HAVE GREAT

5407
03:40:05,120 --> 03:40:06,560
ENGAGEMENT IN OVER THE LAST TWO

5408
03:40:06,560 --> 03:40:13,560
DECADES.  WE ARE ALSO OPERATING

5409
03:40:13,560 --> 03:40:14,960
ARM OF NIH PUBLIC ACCESS POLICY,

5410
03:40:14,960 --> 03:40:17,000
I WILL SHOW YOU MOVE SOME OF THE

5411
03:40:17,000 --> 03:40:17,960
OTHER FEDERAL AGENCY AND

5412
03:40:17,960 --> 03:40:20,120
NON-FEDERAL PUBLIC ACCESS

5413
03:40:20,120 --> 03:40:22,120
POLICIES BECAUSE WE OPERATE IT

5414
03:40:22,120 --> 03:40:23,480
NATIONAL LIBRARY OF MEDICINE

5415
03:40:23,480 --> 03:40:26,040
PUBMED CENTRAL REPOSITORY OR

5416
03:40:26,040 --> 03:40:27,760
ARCHIVE FULL TEXT JOURNAL

5417
03:40:27,760 --> 03:40:29,440
LITERATURE WHICH GIVES US

5418
03:40:29,440 --> 03:40:30,720
ANOTHER ENTRY POINT INTO THIS

5419
03:40:30,720 --> 03:40:35,880
DISCUSSION AND DEBATE.  I HAVE

5420
03:40:35,880 --> 03:40:36,800
SOME SLIDES THAT MIGHT BE

5421
03:40:36,800 --> 03:40:38,480
EASIEST FOR ME TO SHARE FROM

5422
03:40:38,480 --> 03:40:47,760
HERE IF THAT IS FINE. ARE Y'ALL

5423
03:40:47,760 --> 03:40:51,320
SEEING THAT NOW?

5424
03:40:51,320 --> 03:40:55,880
>> GREAT. LET ME JUST
STATE AS

5425
03:40:55,880 --> 03:40:57,840
MY SAID THERE WAS OSTP MEMO,

5426
03:40:57,840 --> 03:41:00,040
WHITE HOUSE OFFICE OF SCIENCE

5427
03:41:00,040 --> 03:41:02,640
TECHNOLOGY MEMO IN 2013 THAT

5428
03:41:02,640 --> 03:41:04,600
SPREAD PUBLIC ACCESS WHICH IS

5429
03:41:04,600 --> 03:41:07,960
OUR TERMINOLOGY FOR IT HERE AT

5430
03:41:07,960 --> 03:41:08,320
NIH

5431
03:41:08,320 --> 03:41:09,800
>> YOUR SLIDES ARE NOT
SHOWING.

5432
03:41:09,800 --> 03:41:10,720
SOMETHING YOU DID PRESENTATION

5433
03:41:10,720 --> 03:41:20,880
BLUE IT. 

5434
03:41:34,480 --> 03:41:36,320
>> IF IT IS SHOWING FULL
SCREEN.

5435
03:41:36,320 --> 03:41:36,880
HOW IS IS THAT?

5436
03:41:36,880 --> 03:41:39,800
>> WE CAN SEE THAT. NOT IN
SLIDE

5437
03:41:39,800 --> 03:41:40,680
SHOW MODE BUT WE CAN SEE I.

5438
03:41:40,680 --> 03:41:42,840
>> SOON AS IT GOES THE
SLIDE

5439
03:41:42,840 --> 03:41:45,680
SHOW MODE IT WILL BE ON SCREEN

5440
03:41:45,680 --> 03:41:49,680
3. (OVERLAPPING SPEAKERS)

5441
03:41:49,680 --> 03:41:51,960
>> OUR WORK AT NIH ON THIS
ISSUE

5442
03:41:51,960 --> 03:41:53,600
IS FRAMED AROUND PUBLIC ACCESS.

5443
03:41:53,600 --> 03:41:55,200
ENSURING THAT THE PUBLIC HAS

5444
03:41:55,200 --> 03:41:57,960
FREE AND TIMELY ACCESS TO THE

5445
03:41:57,960 --> 03:42:01,200
RESULTSES OF PUBLISHED RESEARCH

5446
03:42:01,200 --> 03:42:02,840
THAT THAT NIH FUNDED.  IT COMES

5447
03:42:02,840 --> 03:42:04,920
FROM A LEGISLATIVE REQUIREMENT

5448
03:42:04,920 --> 03:42:07,640
BACK TO 2008, THE TEXT OF THAT

5449
03:42:07,640 --> 03:42:09,080
REQUIREMENT IS HERE. THAT IS

5450
03:42:09,080 --> 03:42:11,000
WHAT WE HAVE BEEN IMPLEMENTING

5451
03:42:11,000 --> 03:42:13,680
NOW OVER LAST 14 YEARS. T THIS

5452
03:42:13,680 --> 03:42:14,480
APPLIES TO ANY ARTICLES THAT

5453
03:42:14,480 --> 03:42:17,440
WERE ACCEPTED FOR PUBLICATION

5454
03:42:17,440 --> 03:42:20,920
AFTER EARLY APRIL OF 2008. IF

5455
03:42:20,920 --> 03:42:22,800
NIH FUNDS YOU, YOUR ARTICLE OR

5456
03:42:22,800 --> 03:42:25,120
THE FINAL PEER REVIEWED

5457
03:42:25,120 --> 03:42:25,760
MANUSCRIPT REFLECTING ALL THE

5458
03:42:25,760 --> 03:42:28,000
CHANGES FROM PEER REVIEW

5459
03:42:28,000 --> 03:42:29,960
PROCESS, NEEDS TO MAKE INTO

5460
03:42:29,960 --> 03:42:31,680
PUBMED CENTRAL AT NLM WHERE IT

5461
03:42:31,680 --> 03:42:33,280
WILL BE RELEASED NO LATER THAN

5462
03:42:33,280 --> 03:42:34,840
12 MONTHS AFTER THE PUBLICATION

5463
03:42:34,840 --> 03:42:39,840
DATE.  THAT IS WHAT OUR POLICY

5464
03:42:39,840 --> 03:42:44,440
IS BASED ON. JUST TO GIVE A SNAP

5465
03:42:44,440 --> 03:42:46,760
SHOT ABOUT WHERE WE ARE 18 YEARS

5466
03:42:46,760 --> 03:42:48,720
LATER -- 14 YEARS LATER WE HAVE

5467
03:42:48,720 --> 03:42:52,920
IN PUBMED CENTRAL 1.3 MILLION

5468
03:42:52,920 --> 03:42:55,040
NIH SUPPORTED ARTICLES THAT DATE

5469
03:42:55,040 --> 03:42:58,840
FROM THAT 2008 YEAR TO PRESENT. 

5470
03:42:58,840 --> 03:43:02,800
WE ADD MORE THAN 100,000 SUCH

5471
03:43:02,800 --> 03:43:05,480
ARTICLES EVERY YEAR SO MAKING

5472
03:43:05,480 --> 03:43:06,680
MORE THAN 100,000 ARTICLES

5473
03:43:06,680 --> 03:43:07,880
REPORTING ON NIH FUNDED RESEARCH

5474
03:43:07,880 --> 03:43:09,120
EVERY YEAR. DEPENDING HOW YOU

5475
03:43:09,120 --> 03:43:10,720
LOOK AT THINGS IF YOU ARE

5476
03:43:10,720 --> 03:43:13,440
OPTIMIST OR PESSIMIST, A LITTLE

5477
03:43:13,440 --> 03:43:17,360
OVER HALF THOSE ARTICLES USE THE

5478
03:43:17,360 --> 03:43:18,760
MAXIMUM 12 MONTH EMBARGO PERIOD

5479
03:43:18,760 --> 03:43:21,760
THAT IS ALLOWED SO CURRENTLY

5480
03:43:21,760 --> 03:43:23,320
ABOUT 22,000 PLUS ARTICLES THAT

5481
03:43:23,320 --> 03:43:25,320
ARE UNDER EMBARGO. THE OTHER WAY

5482
03:43:25,320 --> 03:43:29,160
OF LOOKING AT IT IS JUST UNDER

5483
03:43:29,160 --> 03:43:31,240
HALF CHOOSE SHORTER EMBARGO

5484
03:43:31,240 --> 03:43:33,040
PERIOD WHICH IS NO EMBARGO,

5485
03:43:33,040 --> 03:43:34,560
OTHER CASES THREE MONTHS OR SIX

5486
03:43:34,560 --> 03:43:35,200
MONTHS, I DON'T THINK WE HAVE

5487
03:43:35,200 --> 03:43:38,920
TOO MANY THAT ARE BETWEEN SIX

5488
03:43:38,920 --> 03:43:42,800
AND 12. THE COMPLIANCE RATE WE

5489
03:43:42,800 --> 03:43:44,840
ASK TO MEASURE AND REPORT ON IS

5490
03:43:44,840 --> 03:43:47,360
90%. THAT MEANS THAT OVER THE

5491
03:43:47,360 --> 03:43:51,880
COURSE -- SINCE 2008 OF ALL

5492
03:43:51,880 --> 03:43:54,480
ARTICLES SUBJECT TO POLICY WE

5493
03:43:54,480 --> 03:43:57,760
THINK WE HAVE 90% OF THEM IN

5494
03:43:57,760 --> 03:44:03,880
PUBMED CENTRAL NOW ACCESSIBLE TO

5495
03:44:03,880 --> 03:44:04,880
PUBLIC. THE ARTICLES ARE

5496
03:44:04,880 --> 03:44:06,360
COMPRISED A FRACTION, THAT IS A

5497
03:44:06,360 --> 03:44:08,120
FIFTH OF ALL THE CONSENT

5498
03:44:08,120 --> 03:44:10,200
WEEVILEDDABLE IN PUBMED CENTRAL.

5499
03:44:10,200 --> 03:44:13,480
BUT THEY ARE HIGHLY USED. SO

5500
03:44:13,480 --> 03:44:16,760
THEY ATTRACT MORE THAN TWICE

5501
03:44:16,760 --> 03:44:18,840
THEIR PROPORTION OF VIEWS AND

5502
03:44:18,840 --> 03:44:21,040
DOWNLOADS ANNUALLY SO THEY COUNT

5503
03:44:21,040 --> 03:44:23,320
FOR 42% OF THOSE.  THEY COME TO

5504
03:44:23,320 --> 03:44:26,320
US IN TWO WAYS. CURRENTLY IN THE

5505
03:44:26,320 --> 03:44:29,160
BLUE IN THE CHART, ABOUT 54% OF

5506
03:44:29,160 --> 03:44:30,400
THE ARTICLES COME AS MANUSCRIPTS

5507
03:44:30,400 --> 03:44:34,920
DIRECTLY FROM THE AUTHORS.  WE

5508
03:44:34,920 --> 03:44:36,280
HAVE BEEN WORKING WITH

5509
03:44:36,280 --> 03:44:38,160
PUBLISHERS FOR MANY YEARS MANY

5510
03:44:38,160 --> 03:44:39,520
WHO WILL SUBMIT ARTICLES ON

5511
03:44:39,520 --> 03:44:42,400
BEHALF OF NIH FUNDED RESEARCHERS

5512
03:44:42,400 --> 03:44:45,760
AND AUTHORS SO WE ARE GETTING

5513
03:44:45,760 --> 03:44:47,960
46% OF THOSE FROM PUBLISHER

5514
03:44:47,960 --> 03:44:50,120
THEMSELVES, WHICH WORKS BETTER

5515
03:44:50,120 --> 03:44:51,120
FOR EVERYONE, WORKS BETTER FOR

5516
03:44:51,120 --> 03:44:52,840
US BECAUSE WE GET THEM IN FORMAT

5517
03:44:52,840 --> 03:44:56,560
TYPICALLY THAT WE WANT. EASIER

5518
03:44:56,560 --> 03:44:58,240
FOR RESEARCHERS AS WELL BECAUSE

5519
03:44:58,240 --> 03:44:59,640
WE DON'T DO ANY CHECKING WE

5520
03:44:59,640 --> 03:45:02,320
CONVERTED THESE INTO A STANDARD

5521
03:45:02,320 --> 03:45:03,720
FORMAT THAT WE HAVEN'T MADE

5522
03:45:03,720 --> 03:45:04,320
ERRORS THAT NEED TO BE

5523
03:45:04,320 --> 03:45:10,760
CORRECTED.  SO WE ARE DOING WELL

5524
03:45:10,760 --> 03:45:13,880
WILL POLICY IMPLEMENTATION.

5525
03:45:13,880 --> 03:45:15,720
1.3 MILLION ARTICLES IN PUBMED

5526
03:45:15,720 --> 03:45:17,160
CENTRAL FROM NIH FUNDING DURING

5527
03:45:17,160 --> 03:45:20,200
THE TIME PERIOD, CLOSE TO 8

5528
03:45:20,200 --> 03:45:21,280
MILLION FULL TEXT ARTICLES IN

5529
03:45:21,280 --> 03:45:27,200
PUBMED CENTRAL NOW. OF A THAT

5530
03:45:27,200 --> 03:45:28,480
1.310 MILLION% ARE SITE NINDS

5531
03:45:28,480 --> 03:45:30,080
FUNDING OR COULD COME FROM

5532
03:45:30,080 --> 03:45:32,680
INTRAMURAL RESEARCH PROGRAM SO I

5533
03:45:32,680 --> 03:45:33,600
THINK NINDS IS WELL REPRESENTED

5534
03:45:33,600 --> 03:45:38,480
IN THAT MIX.  WE ARE MEETING ONE

5535
03:45:38,480 --> 03:45:39,120
OF THE AMBITIONS OF THIS EFFORT

5536
03:45:39,120 --> 03:45:42,400
WHICH WAS TO ENSURE THAT THE

5537
03:45:42,400 --> 03:45:43,880
PUBLIC INCLUDING RESEARCH EARS,

5538
03:45:43,880 --> 03:45:47,560
STUDENTS, CLINICS, FRIENDS AND

5539
03:45:47,560 --> 03:45:48,680
FAMILY PATIENTS AND THEIR

5540
03:45:48,680 --> 03:45:50,080
FAMILIES HAVE ACCESS TO THIS

5541
03:45:50,080 --> 03:45:52,280
CONTENT, WE HAVE 3 MILLION

5542
03:45:52,280 --> 03:45:53,600
UNIQUE USERS OF PUBMED CENTRAL

5543
03:45:53,600 --> 03:45:56,640
EVERY DAY.  THEY DOWNLOAD

5544
03:45:56,640 --> 03:45:58,240
BETWEEN 7 1/2 AND 8 MILLION

5545
03:45:58,240 --> 03:45:59,480
ARTICLES ON TYPICAL DAY. YOU CAN

5546
03:45:59,480 --> 03:46:00,640
SEE IT WAXES AND WANES A LITTLE

5547
03:46:00,640 --> 03:46:04,480
BIT WITH THE SEASONS.  SOME OF

5548
03:46:04,480 --> 03:46:06,040
THAT BEING AROUND ACADEMIC

5549
03:46:06,040 --> 03:46:08,600
CALENDAR AS WELL. IT IS FAIRLY

5550
03:46:08,600 --> 03:46:11,880
STEADY GROWTH IN CONTENT AND

5551
03:46:11,880 --> 03:46:13,640
COMMENSURATE GROWTH IN THE

5552
03:46:13,640 --> 03:46:18,000
AMOUNT OF USAGE IN PMC. AS I

5553
03:46:18,000 --> 03:46:19,240
MENTIONED WE HAVE BEEN USING

5554
03:46:19,240 --> 03:46:23,160
PUBMED SENTRA L TO SUPPORT OTHER

5555
03:46:23,160 --> 03:46:25,800
INSTITUTIONS WITH PUBLIC ACCESS

5556
03:46:25,800 --> 03:46:28,880
POLICIES. AMY MENTIONED THIS

5557
03:46:28,880 --> 03:46:31,040
OSTP MEMO FROM TEN YEARS AGO

5558
03:46:31,040 --> 03:46:32,440
THAT REQUIRES EVERY AGENCY WITH

5559
03:46:32,440 --> 03:46:35,200
MORE THAN $100.000000 IN ADD

5560
03:46:35,200 --> 03:46:38,680
EXPENDITURES TO HAVE A SIMILAR

5561
03:46:38,680 --> 03:46:40,240
POLICY, WE SUPPORT NINE AGENCIES

5562
03:46:40,240 --> 03:46:41,280
INCLUDING THE MAJOR COMPONENTS

5563
03:46:41,280 --> 03:46:44,240
OF THE DEPARTMENT OF HEALTH AND

5564
03:46:44,240 --> 03:46:45,920
HUMAN SERVICES AS WELL AS EAR

5565
03:46:45,920 --> 03:46:47,880
AGENCIES HERE INCLUDING THE EPA

5566
03:46:47,880 --> 03:46:51,880
NIST AND THE VA. WE ALSO HAVE

5567
03:46:51,880 --> 03:46:55,560
DONE SOME SUPPORT FOR OTHER

5568
03:46:55,560 --> 03:46:57,280
PRIVATE FUNDERS, SO WE HAVE

5569
03:46:57,280 --> 03:46:58,480
HOWARD HUGHES AND GATES

5570
03:46:58,480 --> 03:47:00,040
FOUNDATION WITH PUBLIC ACCESS

5571
03:47:00,040 --> 03:47:03,600
POLICIES THAT USE PMC AS

5572
03:47:03,600 --> 03:47:04,680
PLATFORM, HEALTH RESEARCH

5573
03:47:04,680 --> 03:47:07,760
ALLIANCE BRINGS TOGETHER A

5574
03:47:07,760 --> 03:47:09,680
CONSORTIUM OF OTHER HEALTH

5575
03:47:09,680 --> 03:47:10,480
RELATED BIOMEDICAL RESEARCH

5576
03:47:10,480 --> 03:47:11,680
FUNDERS, SMALLER FUNDERS AND WE

5577
03:47:11,680 --> 03:47:13,480
HAVE BEEN WORKING WITH EUROPEAN

5578
03:47:13,480 --> 03:47:15,800
FUNDERS AS WELL. THERE IS A MERE

5579
03:47:15,800 --> 03:47:17,840
SITE OF PUBMED CENTRAL IN

5580
03:47:17,840 --> 03:47:20,920
EUROPE. WE WORKED WITH A FEW NIH

5581
03:47:20,920 --> 03:47:23,360
INITIATIVES THAT HAVE MORE

5582
03:47:23,360 --> 03:47:24,160
AGGRESSIVE PUBLIC ACCESS

5583
03:47:24,160 --> 03:47:29,200
POLICIES CALLING FOR ACCESS TO

5584
03:47:29,200 --> 03:47:30,680
PUBLISHED RESULTS OF RESEARCH

5585
03:47:30,680 --> 03:47:32,720
LIKE CANCER MOON SHOT OR HEAL

5586
03:47:32,720 --> 03:47:33,920
INITIATIVE ENDING ADDICTION AND

5587
03:47:33,920 --> 03:47:35,120
THE ALL OF US PROGRAM WHICH IS

5588
03:47:35,120 --> 03:47:37,040
DIFFERENT AS WELL IN THAT THE

5589
03:47:37,040 --> 03:47:38,880
POLICY IS NOT JUST FUNDED

5590
03:47:38,880 --> 03:47:41,440
RESEARCHERS BUT USER OF THE ALL

5591
03:47:41,440 --> 03:47:42,520
OF US DATA. MOST CURRENTLY ARE

5592
03:47:42,520 --> 03:47:44,800
FUNDED BY NIH. SO WE HAVE WORKED

5593
03:47:44,800 --> 03:47:47,320
OUT SOME WAYS TO SUPPORT THOSE

5594
03:47:47,320 --> 03:47:51,480
VARIATIONS IN POLICIES.  WE HAVE

5595
03:47:51,480 --> 03:47:53,600
ALSO DONE SOME THINGS PEOPLE

5596
03:47:53,600 --> 03:47:54,720
VIEW PUBMED AS PLACE TO COME

5597
03:47:54,720 --> 03:47:56,360
READ THE LITERATURE. THAT IS

5598
03:47:56,360 --> 03:47:58,000
OFTEN WHAT THOSE 3 MILLION

5599
03:47:58,000 --> 03:48:00,080
PEOPLE PER DAY USE. BUT WE ALSO

5600
03:48:00,080 --> 03:48:01,280
KNOW THERE IS A LOT OF INTEREST

5601
03:48:01,280 --> 03:48:03,560
IN USING ARTIFICIAL INTELLIGENCE

5602
03:48:03,560 --> 03:48:05,720
MACHINE LEARNING OTHER TEXT

5603
03:48:05,720 --> 03:48:07,080
MINING ALGORITHMS TO HELP YOU

5604
03:48:07,080 --> 03:48:08,880
SORT THROUGH OR FIND NEW THINGS

5605
03:48:08,880 --> 03:48:13,920
IN THE LITERATURE.  SO WE MADE

5606
03:48:13,920 --> 03:48:15,840
SUB SETS OPEN FOR DOWNLOADING

5607
03:48:15,840 --> 03:48:22,760
FOR COMPUTATIONAL USE.  IN BULK 

5608
03:48:22,760 --> 03:48:25,720
AUDIENCE WITH BROAD CURE RAYTIVE

5609
03:48:25,720 --> 03:48:27,000
LICENSE WITH BROAD RIGHTS GIVEN,

5610
03:48:27,000 --> 03:48:28,680
CAN BE DOWN LOADED ABOUT 4

5611
03:48:28,680 --> 03:48:31,800
MILLION NOW, ANY NIH AUTHOR

5612
03:48:31,800 --> 03:48:33,920
MANUSCRIPTS THAT WE ACCEPT,

5613
03:48:33,920 --> 03:48:37,160
750,000 OF THEM NOW ARE ALSO

5614
03:48:37,160 --> 03:48:39,200
AVAILABLE FOR TEXT MINING

5615
03:48:39,200 --> 03:48:40,600
APPLICATION AS WELL AS

5616
03:48:40,600 --> 03:48:41,680
HISTORICAL COLLECTIONS OF BOOK

5617
03:48:41,680 --> 03:48:44,240
AND BOOK CHAPTERS.  WE HAVE ALSO

5618
03:48:44,240 --> 03:48:46,640
BEEN DOING WORK TO SUPPORT DATA

5619
03:48:46,640 --> 03:48:47,440
DISCOVERY THROUGH PUBMED

5620
03:48:47,440 --> 03:48:49,200
CENTRAL. THERE IS A LOT OF OTHER

5621
03:48:49,200 --> 03:48:51,880
WORK THAT WE CAN TALK ABOUT TO

5622
03:48:51,880 --> 03:48:55,880
SUPPORT DATA MANAGEMENT SHARING

5623
03:48:55,880 --> 03:48:57,240
AND DISCOVERY, WE HAVE 3 MILLION

5624
03:48:57,240 --> 03:48:58,720
USER EVER DAY FINDING THE

5625
03:48:58,720 --> 03:49:00,120
LITERATURE WHICH IS OFTEN A

5626
03:49:00,120 --> 03:49:02,760
STEPPINGSTONE TO FINDING DATA.

5627
03:49:02,760 --> 03:49:04,560
WE HAVE BEEN DOING WORK TO HELP

5628
03:49:04,560 --> 03:49:07,960
MAKE THAT ASSOCIATED DATA MORE

5629
03:49:07,960 --> 03:49:09,560
VISIBLE IN PUBMED, WE CALL IT

5630
03:49:09,560 --> 03:49:13,000
THE DATA BO BO BOX. SO THERE ISA

5631
03:49:13,000 --> 03:49:14,680
CITATION WE COLLECT

5632
03:49:14,680 --> 03:49:16,960
SUPPLEMENTARY MATERIALS WHICH

5633
03:49:16,960 --> 03:49:20,160
INCLUDE DATA FINDING DATA

5634
03:49:20,160 --> 03:49:21,040
AVAILABILITY STATEMENTS IN

5635
03:49:21,040 --> 03:49:22,560
JOURNAL ARTICLES, WE WILL DO

5636
03:49:22,560 --> 03:49:24,080
MORE TO SURFACE THOSE AND

5637
03:49:24,080 --> 03:49:25,040
PROVIDE LINKS TO THOSE AND THERE

5638
03:49:25,040 --> 03:49:28,280
IS A DATA CITATION WITH A LINK

5639
03:49:28,280 --> 03:49:32,920
OUT TO ASSOCIATED DATA. WE HAVE

5640
03:49:32,920 --> 03:49:34,160
SEEN INCREASE IN THIS OVER THE

5641
03:49:34,160 --> 03:49:36,760
YEARS. CURRENTLY ABOUT 40% OF

5642
03:49:36,760 --> 03:49:40,200
THE MATERIAL WE HAVE IN PMC HAS

5643
03:49:40,200 --> 03:49:41,760
SUPPLEMENTAL MATERIAL. MUCH OF

5644
03:49:41,760 --> 03:49:43,440
OF WHICH IS SUPPLEMENTARY DATA,

5645
03:49:43,440 --> 03:49:45,320
UP FROM 27% TEN PLUS YEARS AGO. 

5646
03:49:45,320 --> 03:49:49,920
YOU CAN SEE STILL A FRACTION OF

5647
03:49:49,920 --> 03:49:51,640
THE OVERALL CONTEMPT BUT GREATER

5648
03:49:51,640 --> 03:49:52,560
EFFORTS AROUND DATA MANAGEMENT

5649
03:49:52,560 --> 03:49:54,680
AND SHARING INCLUDING THE FOURTH

5650
03:49:54,680 --> 03:49:56,320
COMING NIH POLICY WE EXPECT TO

5651
03:49:56,320 --> 03:49:57,040
SEE THOSE NUMBERS CONTINUE TO

5652
03:49:57,040 --> 03:50:02,720
GROW.  WE DID SOMETHING

5653
03:50:02,720 --> 03:50:04,720
DIFFERENT MORE AGGRESSIVE AND

5654
03:50:04,720 --> 03:50:05,200
SPECIAL DURING THE COVID

5655
03:50:05,200 --> 03:50:11,240
PANDEMIC. SO WITHIN BEFORE WE

5656
03:50:11,240 --> 03:50:12,600
LEFT TO GO ON MASS TELEWORK FROM

5657
03:50:12,600 --> 03:50:15,320
THE NIH IN MARCH, WE WORKED WITH

5658
03:50:15,320 --> 03:50:18,200
THE WHITE HOUSE OFFICE OF

5659
03:50:18,200 --> 03:50:21,120
SCIENCE AND TECHNOLOGY POLICY

5660
03:50:21,120 --> 03:50:22,760
AND LEADERS FROM OTHER COUNTRIES

5661
03:50:22,760 --> 03:50:24,200
TO CALL ON THE PUBLISHERS OF THE

5662
03:50:24,200 --> 03:50:26,400
WORLD TO MAKE THEIR CONTENT

5663
03:50:26,400 --> 03:50:28,400
AROUND THEM WHICH IS LARGELY

5664
03:50:28,400 --> 03:50:30,360
HISTORICAL CORONA VIRUS

5665
03:50:30,360 --> 03:50:30,960
LITERATURE FREELY AND

5666
03:50:30,960 --> 03:50:32,760
IMMEDIATELY ACCESSIBLE THROUGH

5667
03:50:32,760 --> 03:50:36,240
PLATFORMS LIKE PUBMED CENTRAL

5668
03:50:36,240 --> 03:50:38,560
NOT JUST PDF VERSION TO POST FOR

5669
03:50:38,560 --> 03:50:40,600
READING BUT ALSO MACHINE

5670
03:50:40,600 --> 03:50:43,960
READABLE FORMS. WE THEN ALSO

5671
03:50:43,960 --> 03:50:46,080
WORK IN 50 PUBLISHERS INCLUDING

5672
03:50:46,080 --> 03:50:47,800
MAJOR SOCIETIES AND COMMERCIAL

5673
03:50:47,800 --> 03:50:48,800
PUBLISHERS BEGAN WORKING WITH US

5674
03:50:48,800 --> 03:50:51,000
TO DO THAT. WE LAUNCHED A DATA

5675
03:50:51,000 --> 03:50:52,840
SET IN MARCH THAT HAD ABOUT

5676
03:50:52,840 --> 03:50:55,560
30,000 ARTICLES IN IT. THAT IS

5677
03:50:55,560 --> 03:50:57,280
NOW OVER THE ENSUING 2 PLUS

5678
03:50:57,280 --> 03:51:00,440
YEARS GROWN TO 400,000

5679
03:51:00,440 --> 03:51:02,560
PUBLICATIONS THAT DOWNLOADABLE

5680
03:51:02,560 --> 03:51:05,520
SET WE COLLABORATE WITH OUTSIDE

5681
03:51:05,520 --> 03:51:06,680
PARTNERS WHO BROUGHT IN MORE

5682
03:51:06,680 --> 03:51:10,760
CONTENT AND USE TO GENERATE TO

5683
03:51:10,760 --> 03:51:12,400
GENERATE AI MACHINE LEARNING

5684
03:51:12,400 --> 03:51:13,760
NATURAL LANGUAGE PROCESSING

5685
03:51:13,760 --> 03:51:15,040
CHALLENGES AND COMPETITIONS.

5686
03:51:15,040 --> 03:51:17,360
SOMETHING ABOUT IMPROVING SEARCH

5687
03:51:17,360 --> 03:51:18,440
CAPABILITIES, SOMETHING ABOUT WE

5688
03:51:18,440 --> 03:51:19,680
LEARN NEW THINGS HABIT COVID

5689
03:51:19,680 --> 03:51:28,480
FROM THE LITERATURE. THE MEDIA

5690
03:51:28,480 --> 03:51:31,600
SHY OF CONSEN CONSENT TENT. WE D

5691
03:51:31,600 --> 03:51:35,960
TWO YEARS AGO JUNE OF 2020 A

5692
03:51:35,960 --> 03:51:37,240
PRE-PRINT PILOT. UNTIL WE

5693
03:51:37,240 --> 03:51:38,080
LAUNCHED THIS EVERYTHING IN

5694
03:51:38,080 --> 03:51:40,480
PUBMED CENTRAL CAME FROM A

5695
03:51:40,480 --> 03:51:42,000
JOURNAL WE AT NLM REVIEWED.  IT

5696
03:51:42,000 --> 03:51:44,120
WAS CONTENT THAT HAD BEEN PEERRY

5697
03:51:44,120 --> 03:51:46,320
REVIEWED AN CONCERNS ABOUT FEW

5698
03:51:46,320 --> 03:51:49,000
ARE TRUSTED HIGHLY TRUSTED MLM

5699
03:51:49,000 --> 03:51:50,480
LITERATURE SERVICES OFFERING

5700
03:51:50,480 --> 03:51:53,200
NON-PEER REVIEWED CONTENT AND

5701
03:51:53,200 --> 03:51:54,400
WITH ARRIVAL OF THE COVID MANY

5702
03:51:54,400 --> 03:51:57,160
OF THOSE CONCERNS IN THE MEDIA

5703
03:51:57,160 --> 03:51:59,200
SHY DESIRE FOR MEDIA SHY OF

5704
03:51:59,200 --> 03:52:00,880
CONTENT MADE US LAUNCH PROMPTED

5705
03:52:00,880 --> 03:52:05,080
US TO LAUNCH THIS PILOT EFFORT

5706
03:52:05,080 --> 03:52:05,840
WHICH MAKES AVAILABLE THROUGH

5707
03:52:05,840 --> 03:52:07,760
PUBMED CENTRAL WITH CITATION IN

5708
03:52:07,760 --> 03:52:10,160
PUBMED WHICH YOU ARE FAMILIAR

5709
03:52:10,160 --> 03:52:13,440
WITH TOO, PREPRINTS RESULTING

5710
03:52:13,440 --> 03:52:15,680
FROM NIH FUNDED COVID-19

5711
03:52:15,680 --> 03:52:17,560
RESEARCH. WE HAVE DONE THIS IN

5712
03:52:17,560 --> 03:52:18,520
COLLABORATION WITH SOME OF THE

5713
03:52:18,520 --> 03:52:21,880
MAJOR PRE-PRINT SERVERS, WE TOOK

5714
03:52:21,880 --> 03:52:22,840
GREAT PAINS TO MAKE SURE IF YOU

5715
03:52:22,840 --> 03:52:24,240
COME ACROSS A PRE-PRINT IN

5716
03:52:24,240 --> 03:52:26,760
PUBMED CENTRAL OR CITATION IN

5717
03:52:26,760 --> 03:52:28,360
PUBMED, YOU KNOW IT IS A

5718
03:52:28,360 --> 03:52:31,800
PRE-PRINT. BECAUSE YOU SEE THE

5719
03:52:31,800 --> 03:52:33,160
BANNER, WE HAVE GIVEN SOME

5720
03:52:33,160 --> 03:52:35,720
SMALLER PRINT IN INDICATORS IN

5721
03:52:35,720 --> 03:52:37,240
CITATION INFORMATION, WE HAVE

5722
03:52:37,240 --> 03:52:39,040
ALSO ARE PROVIDING LINKS TO A

5723
03:52:39,040 --> 03:52:40,640
PEER REVIEWED VERSION OF THE

5724
03:52:40,640 --> 03:52:44,440
ARTICLE WHERE IT IS POSSIBLE. T

5725
03:52:44,440 --> 03:52:46,480
OVER THE LAST TWO PLUS YEARS WE

5726
03:52:46,480 --> 03:52:51,040
HAVE COLLECTED ABOUT 3200 NOW

5727
03:52:51,040 --> 03:52:52,920
NIH FUNDED COVID-19 RELATED

5728
03:52:52,920 --> 03:52:55,000
PREPRINTS, WHICH IS LESS THAN

5729
03:52:55,000 --> 03:52:56,880
10% OF ALL THE PRE-PRINTS YOU

5730
03:52:56,880 --> 03:52:58,320
MIGHT FIND AROUND COVID-19 YOU

5731
03:52:58,320 --> 03:53:00,960
CAN SEE WHO WE HAVE BEEN

5732
03:53:00,960 --> 03:53:06,400
COLLABORATING WITH. WHAT WE ARE

5733
03:53:06,400 --> 03:53:08,560
BEGINNING TO SEE IS HOW

5734
03:53:08,560 --> 03:53:11,680
PUBLICATION PATTERNS WORKED

5735
03:53:11,680 --> 03:53:14,600
DURING THE PANDEMIC BUT MAYBE

5736
03:53:14,600 --> 03:53:16,520
MORE BROADLY. EVEN FROM TWO

5737
03:53:16,520 --> 03:53:17,840
YEARS AGO ARE STILL AVAILABLE

5738
03:53:17,840 --> 03:53:19,920
ONLY AS A PRE-PRINT AND HAVE NOT

5739
03:53:19,920 --> 03:53:22,560
BEEN ASSOCIATED YET WITH A PEER

5740
03:53:22,560 --> 03:53:23,520
REVIEW JOURNAL ARTICLE. THAT

5741
03:53:23,520 --> 03:53:27,360
NUMBER IS STILL AS HIGH AS 40%.

5742
03:53:27,360 --> 03:53:28,840
GOING BACK COUPLE OF YEARS. WE

5743
03:53:28,840 --> 03:53:30,640
WILL DO WORK TO UNDERSTAND

5744
03:53:30,640 --> 03:53:33,080
BETTER WHAT HAPPENED WITH THOSE.

5745
03:53:33,080 --> 03:53:34,520
IS THAT BECAUSE THERE WAS

5746
03:53:34,520 --> 03:53:37,200
INTEREST IN RAPIDLY REPORTING

5747
03:53:37,200 --> 03:53:39,240
RESULTS BUT NOT AS MUCH PURSUING

5748
03:53:39,240 --> 03:53:43,160
PUBLICATION, WAS IT THAT THEY

5749
03:53:43,160 --> 03:53:45,320
PURSUED PUBLICATION AND RESULTS

5750
03:53:45,320 --> 03:53:47,720
DIDN'T STAND, THERE A LOT TO

5751
03:53:47,720 --> 03:53:48,880
LEARN ABOUT PRE-PRINT NOW AND

5752
03:53:48,880 --> 03:53:53,680
WHAT IT MEANS. IN THE TITLE OF

5753
03:53:53,680 --> 03:53:54,800
THE SLIDE WE ARE NOT ONLY

5754
03:53:54,800 --> 03:53:57,320
ACCELERATING ACCESS TO RESEARCH

5755
03:53:57,320 --> 03:53:59,680
BY THROUGH PREPRINTS BUT MAYBE

5756
03:53:59,680 --> 03:54:01,320
BROADENING THE ACCESS TO

5757
03:54:01,320 --> 03:54:03,000
RESEARCH THAT HAS NOT YET BEEN

5758
03:54:03,000 --> 03:54:04,960
PUBLISHED. SO MAYBE WE CAN

5759
03:54:04,960 --> 03:54:06,080
UNDERSTAND AND SEE MORE CASE

5760
03:54:06,080 --> 03:54:07,400
REPORTS OR SOMETHING ALONG THOSE

5761
03:54:07,400 --> 03:54:08,440
LINES, THAT IS WHAT WE WANT TO

5762
03:54:08,440 --> 03:54:12,400
UNDERSTAND. OUR NLM CONCERN WAS

5763
03:54:12,400 --> 03:54:13,800
DID WE DIMINISH TRUST IN OUR

5764
03:54:13,800 --> 03:54:15,280
RESOURCES BY DOING THIS. WE HAVE

5765
03:54:15,280 --> 03:54:17,040
TAKE AN NUMBER OF APPROACHES TO

5766
03:54:17,040 --> 03:54:18,560
MEASURING IT, I WILL SHARE

5767
03:54:18,560 --> 03:54:25,520
SURVEY RESULTS HERE. MOST PEOPLE

5768
03:54:25,520 --> 03:54:27,200
DID CHANGE IN OUR RESOURCES AT

5769
03:54:27,200 --> 03:54:28,760
ALL. IF ANYTHING A THIRD OF THE

5770
03:54:28,760 --> 03:54:30,320
PEOPLE THOUGHT IT INCREASE TRUST

5771
03:54:30,320 --> 03:54:32,600
BECAUSE THEY COULD NOW SEE INTO

5772
03:54:32,600 --> 03:54:34,520
THE RESEARCH PROCESS. WHAT

5773
03:54:34,520 --> 03:54:35,960
HAPPENED IN CHANGE DURING PEER

5774
03:54:35,960 --> 03:54:37,400
REVIEW PROCESS. YOU ARE SAYING

5775
03:54:37,400 --> 03:54:39,000
THAT IS A POSITIVE SIGNAL WE ARE

5776
03:54:39,000 --> 03:54:41,160
THINKING AT NLM WHETHER OUR

5777
03:54:41,160 --> 03:54:42,920
APPROPRIATE NEXT STEPS WITH

5778
03:54:42,920 --> 03:54:44,560
PREPRINTS DO WE WANT TO EXPAND

5779
03:54:44,560 --> 03:54:46,200
TO BROADER SET OF NIH FUNDED

5780
03:54:46,200 --> 03:54:47,720
RESEARCH, SEE IF THE PATTERNS

5781
03:54:47,720 --> 03:54:53,520
ARE DIFFERENT. THE KEY IS TO

5782
03:54:53,520 --> 03:54:56,400
MAINTAIN TRUSTABILITY OF NLM

5783
03:54:56,400 --> 03:54:57,560
RESOURCES MAKE USE OF PLATFORMS

5784
03:54:57,560 --> 03:55:00,680
WE HAVE THAT SEEM TO BE HIGHLY

5785
03:55:00,680 --> 03:55:02,960
USED. AND PROVIDE CONNECTIONS TO

5786
03:55:02,960 --> 03:55:04,200
OTHER INFORMATION TO HELP PEOPLE

5787
03:55:04,200 --> 03:55:06,920
MAKE GOOD INFORMED RESEARCH

5788
03:55:06,920 --> 03:55:07,840
PROGRAMS, CLINICAL DECISION

5789
03:55:07,840 --> 03:55:09,680
PERSONAL DECISIONS AND B INFORM

5790
03:55:09,680 --> 03:55:11,360
PUBLIC HEALTH. I WILL STOP

5791
03:55:11,360 --> 03:55:12,840
THERE, I WILL TAKE ANY QUESTIONS

5792
03:55:12,840 --> 03:55:14,840
AND I KNOW WE WANT TO MOVE ON BE

5793
03:55:14,840 --> 03:55:16,560
THE DISCUSSION, LOOK FORWARD TO

5794
03:55:16,560 --> 03:55:22,000
HEARING FROM THE OTHER SPEAKERS 

5795
03:55:22,000 --> 03:55:23,000
>> THANK YOU SO MUCH, JOHN
IF

5796
03:55:23,000 --> 03:55:25,840
THERE IS CLARIFYING QUESTIONS,

5797
03:55:25,840 --> 03:55:27,160
OR WE CAN MOVE TO NEXT SPEAKER

5798
03:55:27,160 --> 03:55:30,480
AND HAVE DISCUSSION QUESTIONS

5799
03:55:30,480 --> 03:55:34,080
LATER.

5800
03:55:34,080 --> 03:55:35,320
>> LET'S MOVE ON.

5801
03:55:35,320 --> 03:55:37,320
>> THAT WAS FABULOUS. AS
WE MOVE

5802
03:55:37,320 --> 03:55:39,680
ON I WOULD LIKE TO ENTER DEUCE

5803
03:55:39,680 --> 03:55:41,120
DR. BODO STERN, CHIEF OF

5804
03:55:41,120 --> 03:55:42,040
STRATEGIC INITIATIVES AT THE

5805
03:55:42,040 --> 03:55:44,880
HOWARD HUGHES MEDICAL INSTITUTE 

5806
03:55:44,880 --> 03:55:47,880
HE BECAME HHMI CHIEF STRATEGIC

5807
03:55:47,880 --> 03:55:49,840
INITIATIVES IN P 2018 AND BEFORE

5808
03:55:49,840 --> 03:55:51,520
THAT HE SERVED Z THE CHIEF

5809
03:55:51,520 --> 03:55:52,280
DEVELOPMENT AND STRATEGY

5810
03:55:52,280 --> 03:55:57,120
OFFICER. BEFORE JOINING HHMI

5811
03:55:57,120 --> 03:55:59,600
HEED AS EIGHT YEARS AS DIRECTOR

5812
03:55:59,600 --> 03:56:01,480
OF RESEARCH AFFAIRS AT HARVARD

5813
03:56:01,480 --> 03:56:03,160
SYSTEMS BIOLOGY AND SENIOR

5814
03:56:03,160 --> 03:56:05,920
SCIENTIFIC EDITOR T A CELL.  --

5815
03:56:05,920 --> 03:56:07,520
AT CELL. HE PLAY AD PIVOTAL ROLE

5816
03:56:07,520 --> 03:56:11,840
DEVELOPING HHMI OPEN ACCESS TO

5817
03:56:11,840 --> 03:56:13,440
PUBLICATIONS POLICY AND I LOOK

5818
03:56:13,440 --> 03:56:14,560
FORWARD TO HEARING FROM HIM NOW.

5819
03:56:14,560 --> 03:56:15,160
THANK YOU SO MUCH.

5820
03:56:15,160 --> 03:56:16,200
>> THANK YOU VERY MUCH FOR
THE

5821
03:56:16,200 --> 03:56:17,960
INVITATION AND FOR THE

5822
03:56:17,960 --> 03:56:20,280
INTRODUCTION. CAN YOU HEAR ME? 

5823
03:56:20,280 --> 03:56:24,000
AND SEE THE SLIDES. SO I WANT TO

5824
03:56:24,000 --> 03:56:26,960
SPEND THE NEXT FEW MINUTES TO

5825
03:56:26,960 --> 03:56:29,120
INTRODUCE YOU TO OUR PUBLISHING

5826
03:56:29,120 --> 03:56:31,560
INITIATIVE, WITH A FOCUS ON OUR

5827
03:56:31,560 --> 03:56:33,640
NEW OPEN ACCESS POLICY, THIS

5828
03:56:33,640 --> 03:56:36,440
POLICY JUST WENT INTO AFFECT

5829
03:56:36,440 --> 03:56:38,240
EARLIER THIS YEAR AND IT

5830
03:56:38,240 --> 03:56:39,440
REQUIRES IMMEDIATE OPEN ACCESS

5831
03:56:39,440 --> 03:56:42,280
SO THERE IS NOT A 12 MONTH

5832
03:56:42,280 --> 03:56:43,800
EMBARGO, WE REQUIRE OUR ARTICLES

5833
03:56:43,800 --> 03:56:46,240
TO BE OPEN ACCESS. I WANT TO

5834
03:56:46,240 --> 03:56:47,680
TELL YOU A LITTLE BIT HOW THIS

5835
03:56:47,680 --> 03:56:50,760
IS GOING BUT ALSO HOW WE WANT TO

5836
03:56:50,760 --> 03:56:54,640
BUILD ON THIS POLICY TO REFORM

5837
03:56:54,640 --> 03:56:59,200
SCIENTIFIC PUBLISHING FURTHER.

5838
03:56:59,200 --> 03:57:04,640
OUR OPEN ACCESS POLICY IS

5839
03:57:04,640 --> 03:57:06,920
ALIGNED WITH PLAN S. WE JOINED

5840
03:57:06,920 --> 03:57:10,600
COALITION S IN 2020 WHEN WE

5841
03:57:10,600 --> 03:57:14,360
ANNOUNCE POLICY H. POLICY GO

5842
03:57:14,360 --> 03:57:17,400
INTO EFFECT, THIS COALITION IS

5843
03:57:17,400 --> 03:57:20,520
SORT OF THE GROUP FORMULATED

5844
03:57:20,520 --> 03:57:22,600
PLAN S AND WE LEARNED

5845
03:57:22,600 --> 03:57:23,440
TREMENDOUSLY FROM THAT OPEN

5846
03:57:23,440 --> 03:57:26,280
ACCESS POLICY AND HAVE ADOPTED

5847
03:57:26,280 --> 03:57:28,760
IT IN TO LARGE EXTENT. A FEW

5848
03:57:28,760 --> 03:57:30,400
WORDS ABOUT THIS COALITION, IT

5849
03:57:30,400 --> 03:57:33,600
IS NOW GROWN TO INCLUDE 26

5850
03:57:33,600 --> 03:57:35,200
ORGANIZATIONS WORLDWIDE, STATED

5851
03:57:35,200 --> 03:57:36,840
IN EUROPE AND INCLUDES MANY

5852
03:57:36,840 --> 03:57:39,040
NATIONAL FUNDERS FROM URINE UK

5853
03:57:39,040 --> 03:57:40,680
BUT ALSO FLOW FROM CANADA AND

5854
03:57:40,680 --> 03:57:43,440
AFRICAN COUNTRIES.  IT INCLUDES

5855
03:57:43,440 --> 03:57:44,080
EUROPEAN COMMISSION SO IT COVERS

5856
03:57:44,080 --> 03:57:48,000
A LOT OF THE EUROPEAN FUNDING,

5857
03:57:48,000 --> 03:57:49,360
RESEARCH FUNDING. BUT ALSO

5858
03:57:49,360 --> 03:57:52,920
INCLUDES A LOT OF CHARITABLE

5859
03:57:52,920 --> 03:57:56,600
ORGANIZATIONS, INCLUDES WELCOME

5860
03:57:56,600 --> 03:58:02,280
GATES AND US I THINK THE MALES

5861
03:58:02,280 --> 03:58:03,840
TALK ABOUT EXPERIENCE OF

5862
03:58:03,840 --> 03:58:04,400
COALITION AND OPEN ACCESS

5863
03:58:04,400 --> 03:58:10,640
POLICY.  COALITION S HAS $40

5864
03:58:10,640 --> 03:58:14,000
BILLION RESEARCH FUNDS AND THAT

5865
03:58:14,000 --> 03:58:15,040
COVERS 150,000 ARTICLES, I DON'T

5866
03:58:15,040 --> 03:58:17,760
KNOW EXACTLY, PROBABLY AROUND 5%

5867
03:58:17,760 --> 03:58:22,400
GLOBAL OUTPUT. BUT MUCH HIGHER

5868
03:58:22,400 --> 03:58:24,720
PERCENTAGE IN PRESTIGIOUS

5869
03:58:24,720 --> 03:58:27,440
JOURNALS. THAT HAPPENS TO BE AS

5870
03:58:27,440 --> 03:58:30,480
WE KNOW NOW HAPPENS TO BE ENOUGH

5871
03:58:30,480 --> 03:58:32,800
TO CONVINCE ENOUGH TO CONVINCE

5872
03:58:32,800 --> 03:58:34,760
MANY PUBLISHERS TO AT LEAST

5873
03:58:34,760 --> 03:58:36,200
COMPLY AND OFFER PUBLISHING

5874
03:58:36,200 --> 03:58:39,080
OPTIONS THAT ARE CONSISTENT WITH

5875
03:58:39,080 --> 03:58:40,800
PLAN S AND WITH CELL OPEN ACCESS

5876
03:58:40,800 --> 03:58:44,640
POLICY.  THE CORE FEATURE OF

5877
03:58:44,640 --> 03:58:48,800
PLAN S AND HMI POLICY IS THAT IT

5878
03:58:48,800 --> 03:58:51,000
REQUIRES ARTICLES TO PUBLISH TO

5879
03:58:51,000 --> 03:58:52,880
BE PUBLISHED WITH OPEN ACCESS --

5880
03:58:52,880 --> 03:58:56,480
WITH AN OPEN LICENSE CALLED CC

5881
03:58:56,480 --> 03:58:59,520
BY. THAT ALLOWS ANYBODY TO READ

5882
03:58:59,520 --> 03:59:01,960
ACCESS THIS ARTICLE BUT ALSO TO

5883
03:59:01,960 --> 03:59:04,440
REUSE THE ARTIC ARTICLE. THIS LE

5884
03:59:04,440 --> 03:59:06,440
CONDITION ON THE LICENSE IS THAT

5885
03:59:06,440 --> 03:59:07,760
THE AUTHORS NEEDS TO BE

5886
03:59:07,760 --> 03:59:10,640
ACKNOWLEDGED.  AND THERE ARE TWO

5887
03:59:10,640 --> 03:59:13,040
WAYS THAT OUR SCIENTISTS CAN

5888
03:59:13,040 --> 03:59:19,480
APPLY OPEN LICENSE.  THE FIRST

5889
03:59:19,480 --> 03:59:21,440
OPTION IS LICENSE APPLIED TO

5890
03:59:21,440 --> 03:59:24,600
JOURNAL RECORD THAT IS REFERRED

5891
03:59:24,600 --> 03:59:26,520
TO AS GOLD OPEN ACCESS, THAT

5892
03:59:26,520 --> 03:59:28,040
COMES WITH OPEN ACCESS

5893
03:59:28,040 --> 03:59:29,280
PUBLICATION FEES AND ALL MEMBERS

5894
03:59:29,280 --> 03:59:31,840
OF THE COALITION S HAVE AGREED

5895
03:59:31,840 --> 03:59:34,600
THAT THEY WOULD ONLY PAY THESE

5896
03:59:34,600 --> 03:59:38,600
FEES IF ASSOCIATED WITH A

5897
03:59:38,600 --> 03:59:40,760
JOURNAL THAT HAS FULLY ADOPTED

5898
03:59:40,760 --> 03:59:43,560
OPEN ACCESS MODEL OR AT LEAST

5899
03:59:43,560 --> 03:59:45,880
HAS COMMITTED TO TRANSITIONING

5900
03:59:45,880 --> 03:59:48,240
TO OPEN ACCESS BUSINESS MODEL.

5901
03:59:48,240 --> 03:59:52,360
THAT MEANS WE ARE NOT PAYING

5902
03:59:52,360 --> 03:59:53,680
OPEN ACCESS FEES IN HYBRID

5903
03:59:53,680 --> 03:59:55,600
JOURNALS THAT ARE SUBSCRIPTION

5904
03:59:55,600 --> 03:59:57,920
JOURNALS THAT CHARGE EXTRA FOR

5905
03:59:57,920 --> 04:00:00,600
OFFERING OPEN ACCESS. THE REASON

5906
04:00:00,600 --> 04:00:02,000
IS HAPPY TO GO INTO DETAILS BUT

5907
04:00:02,000 --> 04:00:12,400
THE REASON IS THAT THIS

5908
04:00:19,760 --> 04:00:21,840
SUBSCRIPTION JOURNALS CAN STILL

5909
04:00:21,840 --> 04:00:23,120
PUT THE JOURNAL VERSION BEHIND

5910
04:00:23,120 --> 04:00:24,320
SUBSCRIPTION PAY WALL, THEY CAN

5911
04:00:24,320 --> 04:00:32,080
STILL MAKE MONEY FROM THATTINGS

5912
04:00:32,080 --> 04:00:36,440
VERSION BUT OFFICE COMPLIES

5913
04:00:36,440 --> 04:00:42,480
UNDER CCBY LICEN LICENSE. WE ARE

5914
04:00:42,480 --> 04:00:45,760
GRATEFUL FORE PUBMED TO HOST OUR

5915
04:00:45,760 --> 04:00:48,040
MANUSCRIPT, WE HAVE HAD A GREAT

5916
04:00:48,040 --> 04:00:50,120
RELATIONSHIP WITH PUBMED

5917
04:00:50,120 --> 04:00:53,680
SUPPORTING THIS TRANSITION AND

5918
04:00:53,680 --> 04:00:58,000
IT IS FUN TO WORK. WITH THEM. 

5919
04:00:58,000 --> 04:01:02,320
MANY COALITION MEMBERS HAVE ALSO

5920
04:01:02,320 --> 04:01:06,200
STRENGTHENED THIS GREEN OPTION

5921
04:01:06,200 --> 04:01:08,200
BY ESTABLISHING RIGHTS

5922
04:01:08,200 --> 04:01:10,120
RETENTION. WE HAVE ASKED OUR

5923
04:01:10,120 --> 04:01:13,120
SCIENTISTS TO SIGN AGREEMENT

5924
04:01:13,120 --> 04:01:15,440
THAT MAKES SURE THAT THEY RETAIN

5925
04:01:15,440 --> 04:01:19,440
THE RIGHTS TO THEIR ARTICLES SO

5926
04:01:19,440 --> 04:01:21,360
THEY CAN ALWAYS SHARE AUTHOR

5927
04:01:21,360 --> 04:01:24,120
MANUSCRIPT UNDER CCBY LICENSE IF

5928
04:01:24,120 --> 04:01:26,000
PUBLISHED IN JOURNAL SO THAT

5929
04:01:26,000 --> 04:01:27,160
RIGHT RETENTION IS REALLY AN

5930
04:01:27,160 --> 04:01:30,040
APPROACH TO ENSURE THAT NOT

5931
04:01:30,040 --> 04:01:32,440
HANDING OVER ALL COPYRIGHT TO

5932
04:01:32,440 --> 04:01:35,920
THE PUBLISHERS SO AT LEAST THEY

5933
04:01:35,920 --> 04:01:37,880
CAN STILL HAVE EXCLUSIVE

5934
04:01:37,880 --> 04:01:41,800
COPYRIGHT ON FINAL VERSION BUT

5935
04:01:41,800 --> 04:01:43,560
AUTHOR MANUSCRIPT IS NO LONGER

5936
04:01:43,560 --> 04:01:45,120
EXCLUSIVE LICENSED TO PUBLISHER.

5937
04:01:45,120 --> 04:01:49,280
A FEW WORDS ON THE IMPACT HHMI

5938
04:01:49,280 --> 04:01:51,320
THIS POLICY HAS BEEN IN THE WORK

5939
04:01:51,320 --> 04:01:54,440
FOR YEARS AND BEFORE WE ANNOUNCE

5940
04:01:54,440 --> 04:01:57,280
IN 2020 WE ASK OUR SCIENTISTS,

5941
04:01:57,280 --> 04:01:59,280
WE DID A BIG SURVEY, TURNS OUT

5942
04:01:59,280 --> 04:02:01,320
MOST OF OUR SCIENTISTS ARE

5943
04:02:01,320 --> 04:02:02,520
SUPPORTIVE OF OPEN ACCESS IN

5944
04:02:02,520 --> 04:02:06,320
PRINCIPLE AND THEY ALSO TOLLS

5945
04:02:06,320 --> 04:02:07,520
THERE ARE PROBLEMS WITH

5946
04:02:07,520 --> 04:02:11,280
SCIENTIFIC PUBLISHING AT THE --

5947
04:02:11,280 --> 04:02:12,480
THEY DEFINITELY THINK PUBLISHING

5948
04:02:12,480 --> 04:02:15,760
ISN'T WORKING AS IT SHOULD. BUT

5949
04:02:15,760 --> 04:02:19,120
THEY WERE ORIGINALLY A SPLIT

5950
04:02:19,120 --> 04:02:20,640
ABOUT PULLING A TRIGGER ON AN

5951
04:02:20,640 --> 04:02:23,960
IMMEDIATE OPEN ACCESS -- MAYBE

5952
04:02:23,960 --> 04:02:25,000
THAT IS AN EXPERIENCE THAT YOU

5953
04:02:25,000 --> 04:02:28,760
HAVE SEEN AS WELL. 50%, LIKE

5954
04:02:28,760 --> 04:02:30,600
POLITICS, 50% SCIENTISTS WERE

5955
04:02:30,600 --> 04:02:32,480
STRONGLY IN FAVOR OF MANDATE AND

5956
04:02:32,480 --> 04:02:37,160
50% WERE STRONGLY AGAINST. THE

5957
04:02:37,160 --> 04:02:38,840
MAIN BARRIER IS PEOPLE WITH

5958
04:02:38,840 --> 04:02:40,240
WORRIED WITH PUBLISHING CERTAIN

5959
04:02:40,240 --> 04:02:41,280
JOURNAL AND TRAINEES NOT GOING

5960
04:02:41,280 --> 04:02:44,080
TO GET THEIR JOBS THAT THEY

5961
04:02:44,080 --> 04:02:46,680
SHOULD GET. SO THAT WAS THE MAIN

5962
04:02:46,680 --> 04:02:48,480
FEAR AND AFTER WE ANNOUNCED

5963
04:02:48,480 --> 04:02:51,400
AFTER THIS POLICY IS NOW INTO

5964
04:02:51,400 --> 04:02:52,640
EFFECT, THIS PARTICULAR IS

5965
04:02:52,640 --> 04:02:54,440
PROBABLY NOT ANY MORE SO MUCH ON

5966
04:02:54,440 --> 04:02:55,400
THE FOREFRONT BECAUSE A LOT OF

5967
04:02:55,400 --> 04:02:59,360
THE PUBLISHERS HAVE ACCEPTED

5968
04:02:59,360 --> 04:03:01,640
PUBLISHING OPTION THAT ARE

5969
04:03:01,640 --> 04:03:03,720
COMPLIANT SO THAT PRESTIGIOUS

5970
04:03:03,720 --> 04:03:05,200
JOURNALS OUTS OF REACH, THAT

5971
04:03:05,200 --> 04:03:06,360
HASN'T MATERIALIZED.  THE

5972
04:03:06,360 --> 04:03:08,840
CHALLENGE WE FACE NOW THAT I GET

5973
04:03:08,840 --> 04:03:10,920
A LOT OF EMAILS FROM SCIENCE

5974
04:03:10,920 --> 04:03:17,960
WHAT I CAN TELL IS THE POLICY IS

5975
04:03:17,960 --> 04:03:19,880
COMPLEX.  IT HAS TWO OPTIONS.

5976
04:03:19,880 --> 04:03:21,560
PUBLISHING LICENSE, GOD FORD BY

5977
04:03:21,560 --> 04:03:25,320
THEY NEED TO LOOK AT THE

5978
04:03:25,320 --> 04:03:26,200
PUBLISHING CONTRACT.  THAT'S

5979
04:03:26,200 --> 04:03:28,200
SOMETHING SCIENTISTS DIDN'T NEED

5980
04:03:28,200 --> 04:03:29,560
TO DO. THEY JUST SIGNED THEIR

5981
04:03:29,560 --> 04:03:30,960
RIGHTS IN THE PAST. SO I GET A

5982
04:03:30,960 --> 04:03:35,000
LOT OF QUESTIONS LIKE CAN YOU

5983
04:03:35,000 --> 04:03:39,320
TELL ME JOURNALS TO PUBLISH IN

5984
04:03:39,320 --> 04:03:41,000
AND IT IS NOT THAT SIMPLE, SO

5985
04:03:41,000 --> 04:03:42,200
THAT IS ONE PROBLEM WE ARE

5986
04:03:42,200 --> 04:03:44,480
FACING BUT I THINK THE BIGGEST

5987
04:03:44,480 --> 04:03:46,440
COMPLAINT I HERE IS ABOUT HIGH

5988
04:03:46,440 --> 04:03:52,040
OPEN ACCESS PUBLISHING PEES. I

5989
04:03:52,040 --> 04:03:53,520
SYMPATHIZE THAT, I DON'T THINK

5990
04:03:53,520 --> 04:03:55,280
PUBLISHING SHOULD COST $11,000

5991
04:03:55,280 --> 04:03:56,680
BUT ITS WILL NOT I WILL SAY ALSO

5992
04:03:56,680 --> 04:03:59,760
NOT A PROBLEM OF OPEN ACCESS, IT

5993
04:03:59,760 --> 04:04:03,400
IS A PROBLEM OF JOURNAL BASED

5994
04:04:03,400 --> 04:04:04,520
PUBLISHING SYSTEM THAT IS

5995
04:04:04,520 --> 04:04:05,960
INCREDIBLY EXPENSIVE SO THAT IS

5996
04:04:05,960 --> 04:04:07,320
SOMETHING I WILL COVER -- I WANT

5997
04:04:07,320 --> 04:04:11,640
TO SAY A FEW WORDS ABOUT HOW WE

5998
04:04:11,640 --> 04:04:16,360
THINK THIS WE NEED TO MOVE AWAY

5999
04:04:16,360 --> 04:04:18,720
FROM THIS CURRENT MODEL. I THINK

6000
04:04:18,720 --> 04:04:20,400
WE WON'T ACHIEVE FULL OPEN

6001
04:04:20,400 --> 04:04:23,080
ACCESS IF WE JUST FOCUS ON OPEN

6002
04:04:23,080 --> 04:04:24,680
ACCESS TO THE PRODUCTS. OPEN

6003
04:04:24,680 --> 04:04:26,360
ACCESS TO ARTICLES. WE HAVE

6004
04:04:26,360 --> 04:04:28,520
REALLY NEED TO CONSIDER THE

6005
04:04:28,520 --> 04:04:30,680
PROCESS OF PUBLISHING AND ALSO

6006
04:04:30,680 --> 04:04:33,840
MAKE THAT PROCESS MORE OPEN. SO

6007
04:04:33,840 --> 04:04:36,040
I'M GOING TO SPEND A FEW MORE

6008
04:04:36,040 --> 04:04:38,200
MINUTES ON THIS FIRST NEXT STEP,

6009
04:04:38,200 --> 04:04:39,600
WE WANT TO MOVE BEYOND OPEN

6010
04:04:39,600 --> 04:04:41,080
ACCESS AND WANT TO PROMOTE WHAT

6011
04:04:41,080 --> 04:04:43,200
WE REFER TO AS A FLIP PUBLISHING

6012
04:04:43,200 --> 04:04:45,040
PROCESS. IT IS A LITTLE BIT LIKE

6013
04:04:45,040 --> 04:04:46,840
JERRY ALREADY STARTED TALKING

6014
04:04:46,840 --> 04:04:48,760
ABOUT PRE-PRINTS. WE THINK THIS

6015
04:04:48,760 --> 04:04:50,400
SHOULD BE THE DEFAULT. PEOPLE

6016
04:04:50,400 --> 04:04:52,240
SHARE THEIR WORK AS A PRE-PRINT

6017
04:04:52,240 --> 04:04:54,360
AND THEN JOURNALS AND REVIEW

6018
04:04:54,360 --> 04:04:56,400
SERVICES, DO PEER REVIEW

6019
04:04:56,400 --> 04:04:58,880
AFTERWARDS. THAT IS -- IT

6020
04:04:58,880 --> 04:05:00,680
HAPPENS ALREADY A LITTLE BIT BUT

6021
04:05:00,680 --> 04:05:04,200
WE THINK THIS NEEDS TO BECOME

6022
04:05:04,200 --> 04:05:07,520
DEFAULT. JUST A LITTLE NOTE ON

6023
04:05:07,520 --> 04:05:09,280
ANOTHER NEXT STEP THAT WE ARE

6024
04:05:09,280 --> 04:05:11,240
EXCITED ABOUT BUT REALLY ONLY IN

6025
04:05:11,240 --> 04:05:13,080
PLANNING PHASES RIGHT NOW, WE DO

6026
04:05:13,080 --> 04:05:15,600
WANT TO CREATE AN HHMI

6027
04:05:15,600 --> 04:05:17,200
REPOSITORY THAT WE HOST ALL OPEN

6028
04:05:17,200 --> 04:05:19,920
ACCESS CONTENT ON. DON'T THINK

6029
04:05:19,920 --> 04:05:22,160
OF THIS AS JUST SORT OF AN

6030
04:05:22,160 --> 04:05:23,600
ARCHIVE FOLLOW-UP, WE WANT THIS

6031
04:05:23,600 --> 04:05:29,600
TO BE A DISCOVERY PLATFOR PLATFE

6032
04:05:29,600 --> 04:05:30,880
WANT IT TO BE A PLACE WE

6033
04:05:30,880 --> 04:05:32,480
EXPERIMENT HOW SCIENCE IS

6034
04:05:32,480 --> 04:05:33,800
DISSEMINATE AND ENHANCE THE WORK

6035
04:05:33,800 --> 04:05:36,960
THAT IS ALREADY PUBLISHED IN

6036
04:05:36,960 --> 04:05:41,400
PRE-PRINT SERVICE ARTICLES.  I

6037
04:05:41,400 --> 04:05:43,440
CAN TALK MORE LATER BUT THIS IS

6038
04:05:43,440 --> 04:05:44,400
ONLY POSSIBLE IF YOU HAVE AN

6039
04:05:44,400 --> 04:05:48,440
IMMEDIATE OPEN ACCESS POLICY

6040
04:05:48,440 --> 04:05:49,880
ONLY THEN DO YOU HAVE RIGHTS TO

6041
04:05:49,880 --> 04:05:51,040
PLAY AROUND WITH CONTENT SO THAT

6042
04:05:51,040 --> 04:05:55,320
IS WHAT WE REALLY INTEND TO DO. 

6043
04:05:55,320 --> 04:05:57,040
SO FLIPPING THE PUBLISHING

6044
04:05:57,040 --> 04:05:58,880
PROCESS, IS SOMETHING WE THINK

6045
04:05:58,880 --> 04:06:01,640
WE REALLY WANT TO ENGAGE THE

6046
04:06:01,640 --> 04:06:04,120
COMMUNITY ON EMBRACING. WHERE

6047
04:06:04,120 --> 04:06:06,360
ARTICLES ARE FIRST PUBLISHED AS

6048
04:06:06,360 --> 04:06:08,960
PREPRINTS AND THEN YOU LAYER ON

6049
04:06:08,960 --> 04:06:10,440
TOP OF THIS LAYER TRANSPARENT

6050
04:06:10,440 --> 04:06:12,360
PEER REVIEW PROCESS. ONE OF THE

6051
04:06:12,360 --> 04:06:15,640
CRITICAL FEATURES THAT

6052
04:06:15,640 --> 04:06:17,560
DIFFERENCES WEAN CURRENT SYSTEM

6053
04:06:17,560 --> 04:06:18,760
AND THIS NEW SYSTEM, IN THE NEW

6054
04:06:18,760 --> 04:06:19,760
SYSTEM WHERE YOU FLIP THE

6055
04:06:19,760 --> 04:06:22,760
PROCESS THERE IS NO LONGER

6056
04:06:22,760 --> 04:06:26,760
REJECTION AS WE KNOW IT TODAY.  

6057
04:06:26,760 --> 04:06:27,480
REJECTION AS IN JOURNAL ACCEPTS

6058
04:06:27,480 --> 04:06:29,080
OR REJECTS ARTICLE FOR

6059
04:06:29,080 --> 04:06:30,360
PUBLICATION. THERE IS NO

6060
04:06:30,360 --> 04:06:31,280
REJECTION BECAUSE THE ARTICLE IS

6061
04:06:31,280 --> 04:06:34,600
ALREADY PUBLISHED. AND SO IN

6062
04:06:34,600 --> 04:06:36,680
THIS SYSTEM RIGOR AND RELEVANCE

6063
04:06:36,680 --> 04:06:38,080
OF PIECE OF WORK IS GOING TO BE

6064
04:06:38,080 --> 04:06:40,320
SIGNAL THROUGH A TRANSPARENT

6065
04:06:40,320 --> 04:06:42,440
POST PUBLICATION REVIEW PROCESS

6066
04:06:42,440 --> 04:06:45,560
AND A CURATION PROCESS, THAT CAN

6067
04:06:45,560 --> 04:06:47,120
INCLUDE ENDORSEMENT BY JOURNALS

6068
04:06:47,120 --> 04:06:49,840
BUT IT IS NOT NOW MORE JOURNALS

6069
04:06:49,840 --> 04:06:53,160
REJECT OR ACCEPT PUBLICATION. I

6070
04:06:53,160 --> 04:06:55,880
WANT TO MOTIVATE THIS CHANGE

6071
04:06:55,880 --> 04:06:57,800
WITH A LITTLENY OF COSTS THAT I

6072
04:06:57,800 --> 04:07:00,000
THINK THIS CURRENT REJECTION

6073
04:07:00,000 --> 04:07:03,400
RESUBMISSION CYCLE IMPOSES ON

6074
04:07:03,400 --> 04:07:05,160
OUR SCIENTIFIC ENTERPRISE. I

6075
04:07:05,160 --> 04:07:06,600
MENTIONED THE HIGH PUBLISHING

6076
04:07:06,600 --> 04:07:09,440
COST. IF YOU -- THE JOURNALS ARE

6077
04:07:09,440 --> 04:07:10,800
BUILDING REPUTATION BY BEING

6078
04:07:10,800 --> 04:07:15,040
SELECTIVE. REJECTION RATE

6079
04:07:15,040 --> 04:07:16,320
INCREASED FOR DECADES. THAT

6080
04:07:16,320 --> 04:07:19,440
INCREASE COST. ESPECIALLY AT THE

6081
04:07:19,440 --> 04:07:22,400
HIGHLY PRESTIGIOUS JOURNALS, IT

6082
04:07:22,400 --> 04:07:25,080
ALSO WAISTS REVIEWER AND AUTHOR

6083
04:07:25,080 --> 04:07:27,440
RESOURCES.  IT IS HARDER TO FIND

6084
04:07:27,440 --> 04:07:28,240
REVIEWERS, IF AN ARTICLE NEEDS

6085
04:07:28,240 --> 04:07:31,800
TO BE REVIEWED TWO OR THREE

6086
04:07:31,800 --> 04:07:34,840
TIMES BY TWO OR THREE JOURNALS,

6087
04:07:34,840 --> 04:07:37,400
IT WASTES A LOT OF REVIEW OF

6088
04:07:37,400 --> 04:07:38,720
RESOURCE AND BECOME MORE

6089
04:07:38,720 --> 04:07:41,520
DIFFICULT TO FIND. ALSO DELAYS

6090
04:07:41,520 --> 04:07:43,960
PUBLICATION. POINT JERRY ALSO

6091
04:07:43,960 --> 04:07:45,600
MADE, PREPRINTS ACCELERATE

6092
04:07:45,600 --> 04:07:47,920
PUBLICATION.  IT TAKES LONGER TO

6093
04:07:47,920 --> 04:07:49,960
-- IT IS BIZARRE, TAKES LONGER

6094
04:07:49,960 --> 04:07:50,600
TODAY TO PUBLISH A JOURNAL

6095
04:07:50,600 --> 04:07:53,480
ARTICLE THAN IT TOOK WHEN

6096
04:07:53,480 --> 04:07:55,120
JOURNAL WAS PRINTED BECAUSE OF

6097
04:07:55,120 --> 04:07:55,920
THIS REJECTION RESUBMISSION

6098
04:07:55,920 --> 04:07:57,360
CYCLE.

6099
04:07:57,360 --> 04:08:03,240
THIS PROCESS CAN BE -- AN AUTHOR

6100
04:08:03,240 --> 04:08:07,480
WHO IS DETERMINED CAN TURN

6101
04:08:07,480 --> 04:08:09,680
AROUND AND RESUBMIT REJECTED

6102
04:08:09,680 --> 04:08:11,880
ARTICLE TO NEW -- BECAUSE

6103
04:08:11,880 --> 04:08:13,080
JOURNALS DON'T SHARE ANY

6104
04:08:13,080 --> 04:08:15,520
INFORMATION ON REJECTED

6105
04:08:15,520 --> 04:08:17,000
ARTICLES.  THE WORST COST WE ARE

6106
04:08:17,000 --> 04:08:20,520
PAYING IS IT DEMORALIZES OUR

6107
04:08:20,520 --> 04:08:24,080
TRAINEES. IF A GRADUATE STUDENT

6108
04:08:24,080 --> 04:08:25,480
SPENDS FIVE YEARS ON THEIR PAPER

6109
04:08:25,480 --> 04:08:27,320
AND THEN IT GETS REJECTED WITH

6110
04:08:27,320 --> 04:08:28,720
COMMENTS LIKE THIS IS NOT

6111
04:08:28,720 --> 04:08:30,960
INTERESTING ENOUGH FOR JOURNAL X

6112
04:08:30,960 --> 04:08:32,760
OR Y, IT REALLY DRIVES I THINK

6113
04:08:32,760 --> 04:08:36,640
PEOPLE AWAY FROM SCIENCE. WE

6114
04:08:36,640 --> 04:08:38,400
REALLY FEEL STRONGLY THIS NEEDS

6115
04:08:38,400 --> 04:08:42,360
TO CHANGE. THIS FLIP PROCESS IS

6116
04:08:42,360 --> 04:08:46,440
NOT -- IT IS NOT A PIPE DREAM,

6117
04:08:46,440 --> 04:08:49,120
IT ALREADY EXISTS, JUST ISN'T --

6118
04:08:49,120 --> 04:08:50,880
IT JUST ISN'T DEFAULT, WE HAVE

6119
04:08:50,880 --> 04:08:51,880
TO -- I FEEL LIKE WE HAVE TO

6120
04:08:51,880 --> 04:08:55,320
PUSH THAT IT BECOMES MORE THE

6121
04:08:55,320 --> 04:08:57,200
DEFAULT. eLIFE IS DOING IT,

6122
04:08:57,200 --> 04:08:59,680
THEY HAVE LAST YEAR SHIFTED TO

6123
04:08:59,680 --> 04:09:01,600
MODEL WHERE THEY ONLY REVIEW

6124
04:09:01,600 --> 04:09:02,880
PREPRINT AND THEY ARE PUBLISHED

6125
04:09:02,880 --> 04:09:04,360
JOURNAL AGNOSTIC PEER ARE VIEW

6126
04:09:04,360 --> 04:09:05,400
REPORTS ON ALL PAPERS THEY

6127
04:09:05,400 --> 04:09:08,160
REVIEW.  THERE ARE JOURNAL

6128
04:09:08,160 --> 04:09:10,360
INDEPENDENT REVIEW SERVICES THAT

6129
04:09:10,360 --> 04:09:12,560
ARE GROWING AND GETTING MORE

6130
04:09:12,560 --> 04:09:14,520
IMPORTANT, I HAVE LISTED A FEW

6131
04:09:14,520 --> 04:09:20,280
HERHERE. GRASSROOTS ORGANIZATIOS

6132
04:09:20,280 --> 04:09:22,840
THAT DO GREAT WORK PROMOTING

6133
04:09:22,840 --> 04:09:24,480
PREPRINT AND PRE-PRINT REVIEW.

6134
04:09:24,480 --> 04:09:25,880
THIS IS HAPPENING AND GROWING. 

6135
04:09:25,880 --> 04:09:32,400
I WANT TO END BY LISTING A FEW

6136
04:09:32,400 --> 04:09:33,800
PARTNERSHIP OPPORTUNITIES, WE

6137
04:09:33,800 --> 04:09:35,160
CERTAINLY -- WE ARE NOT BIG

6138
04:09:35,160 --> 04:09:36,720
FLUFF TO DO THIS. WE REALLY -- I

6139
04:09:36,720 --> 04:09:39,120
MEAN WE REALLY NEED PARTNERS TO

6140
04:09:39,120 --> 04:09:40,960
MOVE -- REFORM SCIENTIFIC

6141
04:09:40,960 --> 04:09:46,160
PUBLISHING. WE WOULD LOVE IF

6142
04:09:46,160 --> 04:09:49,560
COALITION S GROWS, INCLUDES MORE

6143
04:09:49,560 --> 04:09:50,120
FEDERAL FUND IN THE U.S. BUT

6144
04:09:50,120 --> 04:09:51,320
THERE ARE OTHER WAYS TO PROMOTE

6145
04:09:51,320 --> 04:09:53,720
OPEN ACCESS, I'M LISTING ONE

6146
04:09:53,720 --> 04:09:55,440
HERE, RIGHTS RETENTION, TO MAKE

6147
04:09:55,440 --> 04:09:57,880
SURE THAT SCIENTISTS KEEP THE

6148
04:09:57,880 --> 04:09:59,440
RIGHTS TO SHARE AUTHOR

6149
04:09:59,440 --> 04:10:02,280
MANUSCRIPTS.  THAT CAN BE DONE

6150
04:10:02,280 --> 04:10:04,080
WITHOUT EVEN ADDRESSING ALL

6151
04:10:04,080 --> 04:10:07,280
THESE COMPLICATIONS ABOUT

6152
04:10:07,280 --> 04:10:10,360
BUSINESS MODELS. IN TERMS OF

6153
04:10:10,360 --> 04:10:13,000
SUPPORTING PROCESS I THINK THE

6154
04:10:13,000 --> 04:10:14,160
TIME IS RIGHT TO BUILD A

6155
04:10:14,160 --> 04:10:16,800
COALITION OF FUNDERS AND MAYBE

6156
04:10:16,800 --> 04:10:18,560
OF SOCIETY PUBLISHERS TO DEVELOP

6157
04:10:18,560 --> 04:10:20,400
A PROCESS AND A BUSINESS MODEL

6158
04:10:20,400 --> 04:10:23,160
TO ACTUALLY SUPPORT THIS

6159
04:10:23,160 --> 04:10:27,760
PROCESS.  AND FINALLY

6160
04:10:27,760 --> 04:10:29,000
RESPONSIBLE RESEARCH -- IF WE

6161
04:10:29,000 --> 04:10:32,440
ARE NOT ALSO CHANGING HOW WE

6162
04:10:32,440 --> 04:10:34,680
ASSESS RESEARCHERS. REWARDING

6163
04:10:34,680 --> 04:10:37,200
OPEN SCIENCE IS OF COURSE, WE

6164
04:10:37,200 --> 04:10:39,280
WILL TALK ABOUT THAT IN THE

6165
04:10:39,280 --> 04:10:40,400
CONTEXT OF WHAT I TALKED ABOUT

6166
04:10:40,400 --> 04:10:42,920
IN PUBLISHING THE ONE CRITICAL

6167
04:10:42,920 --> 04:10:45,880
STEP I WOULD RECOMMEND IS THAT

6168
04:10:45,880 --> 04:10:49,520
WE RECOGNIZE PRE-PRINTS PLUS

6169
04:10:49,520 --> 04:10:52,080
REVIEWS AS PEER REEVED ARTICLES,

6170
04:10:52,080 --> 04:10:54,240
IMPROVEMENT TO JOURNAL ARTICLE.

6171
04:10:54,240 --> 04:10:56,520
WHEN NIH AND HHMI RECOGNIZED

6172
04:10:56,520 --> 04:10:57,640
PREPRINTS AS SIGNS OF

6173
04:10:57,640 --> 04:10:59,240
PRODUCTIVITY A FEW YEARS AGO.

6174
04:10:59,240 --> 04:11:02,320
PREPRINTS TOOK OFF. IT IS

6175
04:11:02,320 --> 04:11:04,520
IMPORTANT WE ALSO SIGNAL THAT

6176
04:11:04,520 --> 04:11:07,560
THE PEER REVIEW OF PRI PRINTSES

6177
04:11:07,560 --> 04:11:15,480
IS VALUABLE. THIS IS MY

6178
04:11:15,480 --> 04:11:16,640
PRESENTATION. THANK YOU FOR

6179
04:11:16,640 --> 04:11:23,440
LISTENING. HAPPY TO DISCUSS. 

6180
04:11:23,440 --> 04:11:25,280
>> THANK YOU FOR APPEARING
ON

6181
04:11:25,280 --> 04:11:26,480
THE ZOOM. DO YOU HAVE A

6182
04:11:26,480 --> 04:11:27,320
CLARIFYING QUESTION BEFORE WE

6183
04:11:27,320 --> 04:11:27,880
MOVE ON?

6184
04:11:27,880 --> 04:11:29,800
>> I WAS WONDERING HOW YOU
ARE

6185
04:11:29,800 --> 04:11:34,280
GOING TO GET PEOPLE TO REVIEW

6186
04:11:34,280 --> 04:11:38,360
PREPRINTED, RIGHT NOW NO

6187
04:11:38,360 --> 04:11:38,960
PREPRINT GETS COMMENTS AND --

6188
04:11:38,960 --> 04:11:41,840
>> I HAVE TO LOOK UP THE

6189
04:11:41,840 --> 04:11:45,320
INTERNET TO FIND START REVIEWING

6190
04:11:45,320 --> 04:11:45,520
THEM?

6191
04:11:45,520 --> 04:11:53,800
>> BECAUSE WE ARE RELYING
ON

6192
04:11:53,800 --> 04:11:55,200
JOURNALS TO DO THIS -- I THINK

6193
04:11:55,200 --> 04:11:57,800
WHAT WE IMMEDIATE TO DO IS IS

6194
04:11:57,800 --> 04:12:00,880
GET ALSO JOURNALS TO COMMIT AND

6195
04:12:00,880 --> 04:12:02,200
PAY THEM FOR COMMITTING TO A

6196
04:12:02,200 --> 04:12:04,640
MORE TRANSPARENT PROCESS.  IT IS

6197
04:12:04,640 --> 04:12:06,160
NOT JUST THAT SCIENTISTS DO IT

6198
04:12:06,160 --> 04:12:11,480
ON THEIR OWN, BUT ALSO THAT

6199
04:12:11,480 --> 04:12:14,240
JOURNALS START CONDUCTING PEER

6200
04:12:14,240 --> 04:12:18,240
REVIEW THAT IS FIT TO BE SHARED

6201
04:12:18,240 --> 04:12:21,720
IN A ATTACHED PREPRINT. IT NEEDS

6202
04:12:21,720 --> 04:12:24,040
TO CHANGE A LITTLE BIT. IT

6203
04:12:24,040 --> 04:12:26,560
SHOULDN'T BE ABOUT PEER REVIEWS

6204
04:12:26,560 --> 04:12:28,360
THAT JUST INFORM SUMS UP THUMBS

6205
04:12:28,360 --> 04:12:32,680
DOWN DECISION, IT SHOULD BE

6206
04:12:32,680 --> 04:12:33,560
SEPARATED FROM THAT ACCEPT

6207
04:12:33,560 --> 04:12:34,480
REJECT DECISION.  THAT IS PART

6208
04:12:34,480 --> 04:12:36,280
OF THE PROBLEM. JOURNALS SHOULD

6209
04:12:36,280 --> 04:12:38,560
BE ABLE TO DO THAT. eLIFE IS

6210
04:12:38,560 --> 04:12:41,000
GOING TO DO IT BUT I HOPE WE CAN

6211
04:12:41,000 --> 04:12:42,440
ENCOURAGE OTHER JOURNALS TO DO

6212
04:12:42,440 --> 04:12:43,720
THAT AS WELL. WE CAN FIGURE HOW

6213
04:12:43,720 --> 04:12:46,720
TO PAY FOR THAT. AND NOT PAY FOR

6214
04:12:46,720 --> 04:12:48,880
THE PUBLISHING BUT PAY FOR PEER

6215
04:12:48,880 --> 04:12:50,080
REVIEW, THAT IS BASICALLY

6216
04:12:50,080 --> 04:12:52,360
FINANCIALLY WHAT WE HAVE TO

6217
04:12:52,360 --> 04:12:55,080
FIGURE OUT HOW TO DO IT. 

6218
04:12:55,080 --> 04:12:55,960
>> ALLAN, QUICK RESPONSE
BEFORE

6219
04:12:55,960 --> 04:12:56,640
WE MOVE ON?

6220
04:12:56,640 --> 04:12:57,960
>> THE YOU SHALL SHOE U.S.
THE

6221
04:12:57,960 --> 04:12:59,760
ELEPHANT IN THE ROOM. WE ALL

6222
04:12:59,760 --> 04:13:03,200
KNOW WHICH JOURNALS ARE THE MOST

6223
04:13:03,200 --> 04:13:05,200
EXPENSIVPENSIVE. BECAUSE IF WE H

6224
04:13:05,200 --> 04:13:08,520
IN NATURE CELL, THE FACT IS IT

6225
04:13:08,520 --> 04:13:10,960
PROVIDES AN PERIMETER TO THE

6226
04:13:10,960 --> 04:13:13,080
TRAINEES, IN THE PROMOTION

6227
04:13:13,080 --> 04:13:14,600
PROCESS, AND UNTIL YOU SOLVE A

6228
04:13:14,600 --> 04:13:16,720
WAY TO REDUCE THAT COST OR

6229
04:13:16,720 --> 04:13:18,840
ELIMINATE IT GETTING I'M

6230
04:13:18,840 --> 04:13:20,080
REVIEWING EDITOR FOR eLIFE AND

6231
04:13:20,080 --> 04:13:21,960
I KNOW THE PROCESS BUT PEOPLE

6232
04:13:21,960 --> 04:13:23,960
CHOOSE TO SEND NATURE BEFORE

6233
04:13:23,960 --> 04:13:26,400
THEY SEND TO ELI.

6234
04:13:26,400 --> 04:13:29,240
>> AGREE. THAT'S WHY I PUT
MY

6235
04:13:29,240 --> 04:13:30,560
LAST POINT WE CAN'T CHANGE THE

6236
04:13:30,560 --> 04:13:32,040
SYSTEM UNLESS WE IN PARALLEL

6237
04:13:32,040 --> 04:13:34,400
CHANGE HOW WE ASSESS SCIENTISTS.

6238
04:13:34,400 --> 04:13:36,560
I DIDN'T PUT IT IN THERE. BUT I

6239
04:13:36,560 --> 04:13:38,800
AGREE, WE NEED TO DE-EMPHASIZE

6240
04:13:38,800 --> 04:13:41,400
AND MAYBE EVEN REMOVE

6241
04:13:41,400 --> 04:13:42,800
RECOGNITION WHERE SOMETHING IS

6242
04:13:42,800 --> 04:13:46,880
-- HAS BEEN PUBLISHED. SO YES.

6243
04:13:46,880 --> 04:13:47,240
RECOGNIZING --

6244
04:13:47,240 --> 04:13:48,560
>> GOOD LUCK.

6245
04:13:48,560 --> 04:13:56,120
>> I MEAN, YEAH. 

6246
04:13:56,120 --> 04:13:57,920
>> GOOD TOPIC FOR BROADER

6247
04:13:57,920 --> 04:13:59,280
DISCUSSION AFTER OUR OTHER

6248
04:13:59,280 --> 04:14:01,080
SPEAKERS GO SO I'M GOING TO

6249
04:14:01,080 --> 04:14:05,200
INTRODUCE OUR THIRD SPEAKER, DR.

6250
04:14:05,200 --> 04:14:07,160
MARINA PICCIOTTO. SHE WAS LISTED

6251
04:14:07,160 --> 04:14:09,560
ON THE AGENDA AS EDITOR AND

6252
04:14:09,560 --> 04:14:10,800
CHIEF PUBLIC DEFENDER'S OFFICE

6253
04:14:10,800 --> 04:14:11,960
JOURNAL NEURONEUROSCIENCE I WILL

6254
04:14:11,960 --> 04:14:13,880
GET TO IN A MOMENT BUT WE KNOW

6255
04:14:13,880 --> 04:14:17,400
HER AS AMAZING NEUROSCIENTIST

6256
04:14:17,400 --> 04:14:19,480
KNOWN FOR HER WORK IN NICOTINE

6257
04:14:19,480 --> 04:14:20,840
ADDICTION MEMORY AND REWARD

6258
04:14:20,840 --> 04:14:22,520
BEHAVIORS.  SHE HAS NUMEROUS

6259
04:14:22,520 --> 04:14:25,280
TITLES INCLUDING THE CHARLES BG

6260
04:14:25,280 --> 04:14:27,680
MURPHY PROFESSOR PSYCHIATRY AND

6261
04:14:27,680 --> 04:14:29,640
PROFESSOR IN THE CHILD STUDY

6262
04:14:29,640 --> 04:14:30,800
CENTER NEUROSCIENCE PHARMACOLOGY

6263
04:14:30,800 --> 04:14:32,440
DEPARTMENTS AT YALE. SHE IS

6264
04:14:32,440 --> 04:14:33,600
DEPUTY DIRECTOR OF THE CODLY

6265
04:14:33,600 --> 04:14:34,880
INSTITUTE FOR NEUROSCIENCE AT

6266
04:14:34,880 --> 04:14:38,200
YALE AMONG OTHER POSITIONS.  

6267
04:14:38,200 --> 04:14:40,560
WITH RESPECT TO THIS PARTICULAR

6268
04:14:40,560 --> 04:14:41,960
TOPIC, SHE ALSO SERVES IN A

6269
04:14:41,960 --> 04:14:43,440
NUMBER OF IMPORTANT EDITORIAL

6270
04:14:43,440 --> 04:14:47,800
POSITIONS. INCLUDING SINCE 2015

6271
04:14:47,800 --> 04:14:48,680
MR. EDDINS: TORR IN CHIEF FOR

6272
04:14:48,680 --> 04:14:49,840
JOURNAL OF NEUROSCIENCE, IN THAT

6273
04:14:49,840 --> 04:14:51,840
ROLE SHE'S A STRONG SUPPORTER

6274
04:14:51,840 --> 04:14:52,960
FOR GREATER RIGOR AND

6275
04:14:52,960 --> 04:14:54,720
TRANSPARENCY IN PUBLISHING

6276
04:14:54,720 --> 04:14:55,920
OVERSEEING A LOT OF EVOLUTION IN

6277
04:14:55,920 --> 04:14:59,400
THE PUBLISHING FIELD, INCLUDING

6278
04:14:59,400 --> 04:15:01,480
BEING AN EARLY SUPPORTER OF

6279
04:15:01,480 --> 04:15:02,160
PRE-PRINT PUBLISHING AND ALSO

6280
04:15:02,160 --> 04:15:04,320
OVERSAW THE TRANSITION AWAY FROM

6281
04:15:04,320 --> 04:15:05,880
PAPER PUBLISHING BECAUSE I DON'T

6282
04:15:05,880 --> 04:15:06,880
KNOW IF EVERYBODY IS AWARE NOW

6283
04:15:06,880 --> 04:15:08,320
THAT WE ARE ALL ONLINE BUT THE

6284
04:15:08,320 --> 04:15:10,880
JOURNAL OF NEUROSCIENCE MOVED

6285
04:15:10,880 --> 04:15:13,880
INTO ON LINE ONLY PUBLISHING IN

6286
04:15:13,880 --> 04:15:16,560
JANUARY.  SO BE THAT I TURN IT

6287
04:15:16,560 --> 04:15:18,000
OVER TO DR. PICCIOTTO AND I LOOK

6288
04:15:18,000 --> 04:15:28,480
FORWARD TO HEARING COMMENTS.

6289
04:15:33,440 --> 04:15:34,560
>> SHE MAY HAVE JUST --

6290
04:15:34,560 --> 04:15:38,600
>> I FROZE AT EXACTLY THE
RIGHT

6291
04:15:38,600 --> 04:15:44,560
MOMENT. MAGIC. SO I DON'T HAVE

6292
04:15:44,560 --> 04:15:48,160
SLIDES TODAY AND I AM HAPPY TO

6293
04:15:48,160 --> 04:15:49,960
EXPAND ON ANY OF THE POINTS THAT

6294
04:15:49,960 --> 04:15:52,200
I'M GOING TO MAKE BUT I COME

6295
04:15:52,200 --> 04:15:55,000
FROM A VERY DIFFERENT

6296
04:15:55,000 --> 04:15:57,960
PERSPECTIVE THAN MY COLLEAGUE

6297
04:15:57,960 --> 04:16:01,520
FROM HHMI. MY NAME AS YOU HEARD

6298
04:16:01,520 --> 04:16:03,520
IS MARINA PICCIOTTO, EDITOR IN

6299
04:16:03,520 --> 04:16:05,080
CHIEF FOR JOURNAL OF

6300
04:16:05,080 --> 04:16:06,400
NEUROSCIENCE AND IT IS A HYBRID

6301
04:16:06,400 --> 04:16:08,560
JOURNAL, IT PROVIDES FULL OPEN

6302
04:16:08,560 --> 04:16:11,160
ACCESS FOR ALL CONTENT AFTER SIX

6303
04:16:11,160 --> 04:16:12,880
MONTHS, IT IS COMPLETELY

6304
04:16:12,880 --> 04:16:14,760
COMPLIANT WITH PLAN S, AUTHORS

6305
04:16:14,760 --> 04:16:16,520
OWN FULL COPYRIGHT TO THEIR WORK

6306
04:16:16,520 --> 04:16:18,120
WE ENCOURAGE SUBMISSION TO

6307
04:16:18,120 --> 04:16:22,560
BIOARCHIVE AT ANY TIME BEFORE OR

6308
04:16:22,560 --> 04:16:23,920
DURING SUBMISSION AND ALSO HAVE

6309
04:16:23,920 --> 04:16:25,520
DIRECT SUBMISSION OPTION FROM

6310
04:16:25,520 --> 04:16:30,840
BIOARCHIVE. WE HAVE AN OPTION

6311
04:16:30,840 --> 04:16:32,360
FOR THOSE WHO WORK LIKE TO BE

6312
04:16:32,360 --> 04:16:34,080
ACCESSED IMMEDIATELY, THERE IS A

6313
04:16:34,080 --> 04:16:35,920
PUBLICATION COST FOR THAT. AND

6314
04:16:35,920 --> 04:16:38,000
WE HAVE BEEN PUBLISHED FOR THE

6315
04:16:38,000 --> 04:16:40,840
LAST 41 YEARS BY THE SOCIETY FOR

6316
04:16:40,840 --> 04:16:42,920
NEUROSCIENCE WHO IS OUR

6317
04:16:42,920 --> 04:16:44,520
PUBLISHER AND GIVES INCREDIBLE

6318
04:16:44,520 --> 04:16:47,080
EDITORIAL FREEDOM BECAUSE THEY

6319
04:16:47,080 --> 04:16:49,400
REALLY HAVE AN INCREDIBLE

6320
04:16:49,400 --> 04:16:50,680
INVESTMENT IN PEER REVIEW. I

6321
04:16:50,680 --> 04:16:52,520
WANT TO CALL OUT ONE OF YOUR

6322
04:16:52,520 --> 04:16:55,680
MEMBERS WHICH IS JOHN MANSEL WHO

6323
04:16:55,680 --> 04:16:57,520
INTRODUCED SOME OF THE POLICIES

6324
04:16:57,520 --> 04:16:59,000
THAT PLAN S PUSHED FOR MORE THAN

6325
04:16:59,000 --> 04:17:02,120
TEN YEARS AGO BEFORE THE OPEN

6326
04:17:02,120 --> 04:17:03,600
ACCESS MANDATES BECAME QUITE

6327
04:17:03,600 --> 04:17:05,200
BROAD. AUTHORS HAVE OWNED THEIR

6328
04:17:05,200 --> 04:17:08,400
OWN COPYRIGHT TO THEIR OWN

6329
04:17:08,400 --> 04:17:10,200
ARTICLES FINAL PUBLISHED VERSION

6330
04:17:10,200 --> 04:17:12,440
SINCE JOHN'S TENURE AND WE HAVE

6331
04:17:12,440 --> 04:17:14,320
MADE EVERYTHING ALL HISTORICAL

6332
04:17:14,320 --> 04:17:16,160
CONTENT IS FULLY OPEN ACCESS AND

6333
04:17:16,160 --> 04:17:20,000
OF COURSE AFTER SIX MONTHS NEW

6334
04:17:20,000 --> 04:17:22,000
CONTENT IS OPEN ACCESS. OUR

6335
04:17:22,000 --> 04:17:23,160
SISTER JOURNAL IS GOLD OPEN

6336
04:17:23,160 --> 04:17:25,080
ACCESS, IT'S PUBLISHED FOR THE

6337
04:17:25,080 --> 04:17:29,440
LAST SEVEN YEARS.  FOR US OPEN

6338
04:17:29,440 --> 04:17:33,360
ACCESS IS PRIMARY GOAL, IT IS

6339
04:17:33,360 --> 04:17:34,680
INCREDIBLY IMPORTANT GOAL BUT

6340
04:17:34,680 --> 04:17:35,720
HOW WE GET SCIENTIFIC

6341
04:17:35,720 --> 04:17:36,400
INFORMATION TO PUBLIC IS

6342
04:17:36,400 --> 04:17:41,640
COMPLEX. PEER REVIEW ADDS VALUE.

6343
04:17:41,640 --> 04:17:44,680
I WOULD LIKE TO GO FURTHER TO

6344
04:17:44,680 --> 04:17:46,640
SAY BLINDED PEER RERUE IS STILL

6345
04:17:46,640 --> 04:17:48,280
SOMETHING THAT IS AN IMPORTANT

6346
04:17:48,280 --> 04:17:50,880
WAY TO GUARANTEE THAT THOSE WITH

6347
04:17:50,880 --> 04:17:52,400
INCREDIBLE AMOUNTS OF PRIVILEGE

6348
04:17:52,400 --> 04:17:55,320
ARE NOT GIVEN EXTRA CREDIT BY

6349
04:17:55,320 --> 04:17:57,520
PEER REVIEWERS WHO WANT TO TO

6350
04:17:57,520 --> 04:17:58,960
CURRY FAVOR. WE HEAR FROM

6351
04:17:58,960 --> 04:18:00,720
TRAINEES THEY WANT PEOPLE TO

6352
04:18:00,720 --> 04:18:01,720
REREVEAL THEMSELVES SO THEY ARE

6353
04:18:01,720 --> 04:18:03,800
FAIR TO PEOPLE WITHOUT POWER AND

6354
04:18:03,800 --> 04:18:05,600
IN FACT IT IS THE OPPOSITE.  IT

6355
04:18:05,600 --> 04:18:08,600
IS THAT PEOPLE WITHOUT POWER

6356
04:18:08,600 --> 04:18:11,040
FEEL CRUSH AND PEOPLE WITH POWER

6357
04:18:11,040 --> 04:18:13,840
ARE GIVEN EXTRA BENEFIT OF THE

6358
04:18:13,840 --> 04:18:16,560
DOUBDOUBT. CURATION ALSO ADDS VE

6359
04:18:16,560 --> 04:18:22,560
AND DESPITE MY FEELINGS ABOUT

6360
04:18:22,560 --> 04:18:23,880
CNS JOURNALS AS COMPETITORS IN

6361
04:18:23,880 --> 04:18:25,800
WAYS THAT ARE HAVE TAKEN CONTENT

6362
04:18:25,800 --> 04:18:27,440
THAT WE WOULD LOVE TO HAVE

6363
04:18:27,440 --> 04:18:28,640
HOSTED AT THE JOURNAL OF

6364
04:18:28,640 --> 04:18:29,800
NEUROSCIENCE, THERE IS NO

6365
04:18:29,800 --> 04:18:31,280
QUESTION THAT OUR TRAINEES

6366
04:18:31,280 --> 04:18:33,400
CAREERS ARE ENHANCED BY BEING

6367
04:18:33,400 --> 04:18:35,480
PICKED OUT OF THE PILE NOT JUST

6368
04:18:35,480 --> 04:18:37,560
BY THOSE WHO ARE IN THEIR FIELD

6369
04:18:37,560 --> 04:18:38,800
BUT BY THOSE PROFESSIONAL

6370
04:18:38,800 --> 04:18:39,880
EDITORS AND THERE SOMETHING TO

6371
04:18:39,880 --> 04:18:43,520
BE SAID FOR PROFESSIONAL EDIT

6372
04:18:43,520 --> 04:18:45,240
EDITORS. THEY ARE DERIDED FOR

6373
04:18:45,240 --> 04:18:46,520
NOT BEING ACTIVE SCIENTIST BUT

6374
04:18:46,520 --> 04:18:48,000
THEY ARE CHOSEN FOR A NUMBER OF

6375
04:18:48,000 --> 04:18:49,560
SKILLS IN IDENTIFYING

6376
04:18:49,560 --> 04:18:53,880
INTERESTING NEW IDEAS THAT SOME

6377
04:18:53,880 --> 04:18:55,560
OF US COULD ADD AS EDITORS OF

6378
04:18:55,560 --> 04:18:57,920
SOCIETY JOURNALS AS WELL.  BOTH

6379
04:18:57,920 --> 04:18:59,640
OF THESE ARE COSTLY. AND THEY

6380
04:18:59,640 --> 04:19:03,480
TAKE TIME. THE MAIN GOAL OF

6381
04:19:03,480 --> 04:19:04,920
PUBLIC ACCESS SHOULD BE TO

6382
04:19:04,920 --> 04:19:07,440
MAXIMIZE ACCESS WHILE

6383
04:19:07,440 --> 04:19:08,760
SIMULTANEOUSLY ALLOWING TIME AND

6384
04:19:08,760 --> 04:19:09,640
VALUE OF PEER REVIEW TO GO

6385
04:19:09,640 --> 04:19:12,840
FORWARD.  A BIG CHANGE AT THIS

6386
04:19:12,840 --> 04:19:14,840
TIME IS WHO PAYS FOR PUBLIC --

6387
04:19:14,840 --> 04:19:18,160
PEER REVIEW. LIBRARY

6388
04:19:18,160 --> 04:19:19,920
SUBSCRIPTIONS ARE A SUBSTANTIAL

6389
04:19:19,920 --> 04:19:21,840
PROPORTION OF JOURNALS ECONOMIC

6390
04:19:21,840 --> 04:19:23,480
MODEL. IF THE JOURNAL WERE TO

6391
04:19:23,480 --> 04:19:25,360
MOVE TO BE FULLY OPEN ACCESS THE

6392
04:19:25,360 --> 04:19:27,160
COST TO AUTHORS WOULD INCREASE

6393
04:19:27,160 --> 04:19:29,720
BY MORE THAN 3 FOLD. THAT MEANS

6394
04:19:29,720 --> 04:19:32,920
WE ARE SHIFTING A SHARED

6395
04:19:32,920 --> 04:19:35,160
RESPONSIBILITY FOR COSTS OF PEER

6396
04:19:35,160 --> 04:19:39,480
REVIEW TO ONE THAT IS ON THE

6397
04:19:39,480 --> 04:19:43,560
AUTHORS ALONE. ANOTHER MODEL HAS

6398
04:19:43,560 --> 04:19:45,880
BEEN FOR PARTICULARLY FOR

6399
04:19:45,880 --> 04:19:47,360
COMMERCIAL PUBLISHERS TO

6400
04:19:47,360 --> 04:19:48,400
NEGOTIATE TRANSFORMATIVE

6401
04:19:48,400 --> 04:19:49,560
AGREEMENTS WITH GOVERNMENTS AND

6402
04:19:49,560 --> 04:19:51,400
FUNDING AGENCIES TO PAY FOR THE

6403
04:19:51,400 --> 04:19:56,320
COSTS OF PEER REVIEW. ONE

6404
04:19:56,320 --> 04:19:57,800
CONCERN ABOUT A SHIFT IS

6405
04:19:57,800 --> 04:19:59,440
NEGOTIATING WITH LARGE NUMBER OF

6406
04:19:59,440 --> 04:20:01,160
FUNDERS REQUIRES AN ENTIRE

6407
04:20:01,160 --> 04:20:02,200
OFFICE DEDICATED TO THOSE

6408
04:20:02,200 --> 04:20:04,240
NEGOTIATIONS. THEY ARE YEARLY

6409
04:20:04,240 --> 04:20:07,640
BECAUSE THEY DEPENDS ON NUMBER

6410
04:20:07,640 --> 04:20:08,920
OF SUBMISSIONS FROM EACH FUNDING

6411
04:20:08,920 --> 04:20:10,720
BODY. THEREFORE THEY JUST

6412
04:20:10,720 --> 04:20:12,120
NEGOTIATING THOSE AGREEMENTS IS

6413
04:20:12,120 --> 04:20:17,520
VERY COSTLY. I HAVE BEEN TOLD BY

6414
04:20:17,520 --> 04:20:20,200
OUR COUNCIL AND BY THE SFN AS

6415
04:20:20,200 --> 04:20:22,040
OUR PUBLISHER THAT NEGOTIATING

6416
04:20:22,040 --> 04:20:23,520
WITH ALL FUNDERS WOULD BE BEYOND

6417
04:20:23,520 --> 04:20:25,840
THE SFN BUDGET AND THEY LET US

6418
04:20:25,840 --> 04:20:27,240
KNOW THAT THE LIKELIHOOD WOULD

6419
04:20:27,240 --> 04:20:28,640
BE THAT THEY -- IT WOULD BE MORE

6420
04:20:28,640 --> 04:20:30,120
COST EFFECTIVE TO SELL THE

6421
04:20:30,120 --> 04:20:32,880
JOURNAL TO LARGE COMMERCIAL

6422
04:20:32,880 --> 04:20:34,760
PUBLISHER WHO HAS SCALE TO

6423
04:20:34,760 --> 04:20:35,680
NEGOTIATE TRANSFORMATIVE

6424
04:20:35,680 --> 04:20:36,800
AGREEMENTS ON A MUCH BROADER

6425
04:20:36,800 --> 04:20:39,720
SCALE. THAT WOULD BE ENORMOUS

6426
04:20:39,720 --> 04:20:41,200
LOSS TO THE JOURNAL WHICH HAS

6427
04:20:41,200 --> 04:20:44,720
HAD THE LUXURY OF FULL EDITORIAL

6428
04:20:44,720 --> 04:20:47,080
AUTONOMY. . SOME FUNDING AGENCY

6429
04:20:47,080 --> 04:20:50,080
SUCH AS WELLCOME TRUST AND HHMI

6430
04:20:50,080 --> 04:20:51,800
REQUIRE BRAN TEES TO PUBLISH

6431
04:20:51,800 --> 04:20:53,400
IMMEDIATELY IN FULLY OPEN ACCESS

6432
04:20:53,400 --> 04:20:55,040
JOURNALS AND THEY ARE REQUIRING

6433
04:20:55,040 --> 04:20:59,440
PEOPLE TO PUBLISH AND FULLY OPEN

6434
04:20:59,440 --> 04:21:00,720
ACCESS JOURNAL BECAUSE THEY

6435
04:21:00,720 --> 04:21:02,320
WON'T PAY OPEN ACCESS FEES AND

6436
04:21:02,320 --> 04:21:03,520
HYPERJOURNALS SO NOT ABLE TO

6437
04:21:03,520 --> 04:21:04,600
HOST MATERIAL FROM THOSE WHO

6438
04:21:04,600 --> 04:21:06,040
DON'T HAVE ANOTHER WAY TO PAY

6439
04:21:06,040 --> 04:21:07,640
OPEN ACCESS FEES TO THE JOURNAL

6440
04:21:07,640 --> 04:21:11,480
OF NEUROSCIENCE. THIS THEN OF

6441
04:21:11,480 --> 04:21:12,840
COURSE PURPOSES PEER REVIEW COST

6442
04:21:12,840 --> 04:21:15,160
TOTS AUTHORS AWAY FROM MIX OF

6443
04:21:15,160 --> 04:21:16,760
SUPPORTERS AND IN THE END ALL

6444
04:21:16,760 --> 04:21:19,480
JOURNALS DO BECOME FULLY OPEN

6445
04:21:19,480 --> 04:21:24,040
ACCESS AND THERE IS A WAY TO WE

6446
04:21:24,040 --> 04:21:25,840
HAVE TO FIND A WAY TO

6447
04:21:25,840 --> 04:21:27,320
DEMOCRATIZE THE COSTS OF

6448
04:21:27,320 --> 04:21:29,080
PUBLICATION INCLUDING TO

6449
04:21:29,080 --> 04:21:32,480
LIBRARIES AND UNIVERSITIES,

6450
04:21:32,480 --> 04:21:34,120
BECAUSE THAT WOULD FAVOR CHOICE

6451
04:21:34,120 --> 04:21:37,760
FOR AUTHOR WHOSE HAVE A ALSO OF

6452
04:21:37,760 --> 04:21:39,400
GRANT MONEY, AND DISFAVOR AUTHOR

6453
04:21:39,400 --> 04:21:41,120
WHOSE DON'T HAVE DEEP POCKETS OR

6454
04:21:41,120 --> 04:21:42,480
WHO COME FROM COUNTRIES OUTSIDE

6455
04:21:42,480 --> 04:21:45,480
OF THE U.S. AND WESTERN EUROPE

6456
04:21:45,480 --> 04:21:48,440
WHERE PUBLICATION BUDGETS ARE

6457
04:21:48,440 --> 04:21:51,520
LIMITED. ONE OF THE THINGS WE

6458
04:21:51,520 --> 04:21:53,280
ARE DOING RIGHT NOW IS

6459
04:21:53,280 --> 04:21:54,720
NEGOTIATING A PILOT AGREEMENT

6460
04:21:54,720 --> 04:21:56,400
WITH UK FUNDERS THAT WILL ALLOW

6461
04:21:56,400 --> 04:21:58,600
BRITISH AUTHORS TO PUN PUBLISH

6462
04:21:58,600 --> 04:22:00,560
NEUROSCIENCE FULLY OPEN ACCESS

6463
04:22:00,560 --> 04:22:01,200
IMMEDIATELY WITH THE COSTS BOSH

6464
04:22:01,200 --> 04:22:03,080
DIRECTLY BY THE FUNDING AGENT

6465
04:22:03,080 --> 04:22:04,640
RECEIVES. BUT IT IS NOT CLEAR

6466
04:22:04,640 --> 04:22:06,320
THAT OTHER FUNDING BODIES FOR

6467
04:22:06,320 --> 04:22:08,800
EXAMPLE, THE NIH WOULD BE ABLE

6468
04:22:08,800 --> 04:22:11,760
TO WOULD WANT TO ADOPT SIMILAR

6469
04:22:11,760 --> 04:22:14,280
TRANSFORMATIVE AGREEMENTS. SOME

6470
04:22:14,280 --> 04:22:15,840
ASPECT OF PUSH TO REFORM

6471
04:22:15,840 --> 04:22:17,920
SCIENTIFIC PUBLISHING SUCH AS

6472
04:22:17,920 --> 04:22:20,640
THOSE OUTLINED IN PLAN S HAVE

6473
04:22:20,640 --> 04:22:22,440
MADE INCREDIBLY POSITIVE

6474
04:22:22,440 --> 04:22:23,360
DIFFERENCE IN SCIENTIFIC

6475
04:22:23,360 --> 04:22:24,040
PUBLISHING AND I THINK THIS

6476
04:22:24,040 --> 04:22:26,560
COULD BE ASSISTED BY NIH.  

6477
04:22:26,560 --> 04:22:28,320
GRANTING FULL COPYRIGHT TO

6478
04:22:28,320 --> 04:22:30,560
AUTHORS PROVIDING A CREATIVE

6479
04:22:30,560 --> 04:22:35,280
COMMONS LICENSE TO FULLY USE ALL

6480
04:22:35,280 --> 04:22:37,280
MATERIALS PUBLISHED FOR OTHER

6481
04:22:37,280 --> 04:22:38,720
SCIENTIFIC WORK AFTER PEER

6482
04:22:38,720 --> 04:22:42,400
REVIEW WOULD REALLY INCREASE

6483
04:22:42,400 --> 04:22:43,280
SHARING OF SCIENTIFIC

6484
04:22:43,280 --> 04:22:45,640
INFORMATION. A MIX OF EARLY

6485
04:22:45,640 --> 04:22:46,840
POSTING ON PRE-PRINT SERVERS

6486
04:22:46,840 --> 04:22:48,600
FOLLOWED BY FORMAL PEER REVIEW

6487
04:22:48,600 --> 04:22:51,240
AND THEN CURATION BY JOURNALS

6488
04:22:51,240 --> 04:22:53,120
AND FINALLY AVAILABILITY ON

6489
04:22:53,120 --> 04:22:54,760
GOVERNMENT ARCHIVES AFTER

6490
04:22:54,760 --> 04:22:56,000
PUBLICATION IS DEFINITELY

6491
04:22:56,000 --> 04:22:58,560
ALREADY CHANGED PUBLISHING. IT

6492
04:22:58,560 --> 04:23:00,560
IS FACILITATED AN SPEEDED UP

6493
04:23:00,560 --> 04:23:01,960
DISSEMINATION PUBLIC DEFENDER'S

6494
04:23:01,960 --> 04:23:02,840
OFFICE SCIENTIFIC INFORMATION

6495
04:23:02,840 --> 04:23:05,360
AND I THINK THIS COMBINATION HAS

6496
04:23:05,360 --> 04:23:07,120
BECOME A DE FACTO SYNERGISTIC

6497
04:23:07,120 --> 04:23:10,200
SOLUTION OF FINDING THE CORRECT

6498
04:23:10,200 --> 04:23:11,840
BALANCE BETWEEN IMMEDIATE ACCESS

6499
04:23:11,840 --> 04:23:15,360
TO SCIENTISTS OF SCIENTIFIC

6500
04:23:15,360 --> 04:23:17,040
DATA, THE VALUE OF PEER REVIEW

6501
04:23:17,040 --> 04:23:18,920
AND CURATION AND THEN THE

6502
04:23:18,920 --> 04:23:24,320
IMPORTANCE OF PUBLIC ACCESS TO

6503
04:23:24,320 --> 04:23:27,000
THE POOR REVIEWED ORGANISM, IT

6504
04:23:27,000 --> 04:23:28,640
IS NOT ONE ORGANIZATION OR MODEL

6505
04:23:28,640 --> 04:23:29,640
THAT DOES THIS, IT IS THE

6506
04:23:29,640 --> 04:23:32,040
COMBINATION OF MULTIPLE ARCHIVES

6507
04:23:32,040 --> 04:23:34,400
AND MULTIPLE LEVELS OF PEER

6508
04:23:34,400 --> 04:23:39,160
REVIEW. I WOULD REALLY LIKE TO

6509
04:23:39,160 --> 04:23:41,600
ADD THAT BIOARCHIVE HAS BEEN

6510
04:23:41,600 --> 04:23:44,280
ESSENTIAL IN GETTING INFORMATION

6511
04:23:44,280 --> 04:23:45,720
OUT TO OTHER SCIENTISTS AND TO

6512
04:23:45,720 --> 04:23:48,040
THE PUBLIC DURING THE NOT ONLY

6513
04:23:48,040 --> 04:23:50,760
DURING THE PANDEMIC BUT IN MANY

6514
04:23:50,760 --> 04:23:54,960
AREAS OF MEDICAL RESEARCH. AND

6515
04:23:54,960 --> 04:23:56,280
HAVING THAT DATA UNPEER REVIEWED

6516
04:23:56,280 --> 04:24:00,200
OF COURSE LEADS TO SOME PROBLEMS

6517
04:24:00,200 --> 04:24:03,920
IN PUBLIC PERCEPTION OF SCIENCE

6518
04:24:03,920 --> 04:24:05,720
OF THE VALUE OF THE SCIENTIFIC

6519
04:24:05,720 --> 04:24:07,160
DATA, HAVING SUBSEQUENT PEER

6520
04:24:07,160 --> 04:24:09,800
REVIEW CAN REALLY MAKE A BIG

6521
04:24:09,800 --> 04:24:12,080
DIFFERENCE IN HOW NON-SCIENTISTS

6522
04:24:12,080 --> 04:24:15,400
USE THAT INFORMATION.  I CAN

6523
04:24:15,400 --> 04:24:17,320
LIKE TO COMMENT POST PUBLICATION

6524
04:24:17,320 --> 04:24:18,800
PEER REVIEW. SCIENTISTS WON'T

6525
04:24:18,800 --> 04:24:20,320
REVIEW UNLESS INVITE AND

6526
04:24:20,320 --> 04:24:22,200
RECOGNIZED FOR THAT REVIEW. AND

6527
04:24:22,200 --> 04:24:24,080
THAT IS WHAT COSTS MONEY, IT IS

6528
04:24:24,080 --> 04:24:27,080
IN FACT THE INFRASTRUCTURE TO

6529
04:24:27,080 --> 04:24:30,120
INVITE FOLLOW-UP WITH AND HELP

6530
04:24:30,120 --> 04:24:33,320
REVIEWERS GET THEIR CONTENT ON

6531
04:24:33,320 --> 04:24:37,600
TO A PLATFORM THAT COSTS MONEY

6532
04:24:37,600 --> 04:24:39,040
TO JOURNALS.S.  IT IS SOMETHINGE

6533
04:24:39,040 --> 04:24:40,200
DON'T KNOW HAPPENS ON BIOARCHIVE

6534
04:24:40,200 --> 04:24:45,200
OR RARELY, I THINK THAT THE

6535
04:24:45,200 --> 04:24:47,880
EXPERIMENT ON PRE-PUBLICATION

6536
04:24:47,880 --> 04:24:51,280
REVIEW IS INTERESTING. BUT SCALE

6537
04:24:51,280 --> 04:24:55,400
IS MINIMAL. IT IS GOING TO BE

6538
04:24:55,400 --> 04:24:57,240
LESS THAN .1% OF THE SCIENTIFIC

6539
04:24:57,240 --> 04:25:01,080
LITERATURE.  IT IS POSSIBLE

6540
04:25:01,080 --> 04:25:02,240
BECAUSE eLIFE IS SUPPORTED BY

6541
04:25:02,240 --> 04:25:03,640
PEOPLE WITH BIG POCKETS AND THAT

6542
04:25:03,640 --> 04:25:06,120
IS HHMI AND WELLCOME TRUST.

6543
04:25:06,120 --> 04:25:07,000
UNLESS WE HAVE FUNDERS THAT ARE

6544
04:25:07,000 --> 04:25:08,200
WILLING TO SUPPORT THAT, IT

6545
04:25:08,200 --> 04:25:11,040
WON'T HAPPEN ON A LARGER SCALE. 

6546
04:25:11,040 --> 04:25:14,520
IT ALSO COMES FROM A POSITION OF

6547
04:25:14,520 --> 04:25:16,120
INCREDIBLE PRIVILEGE I WOULD

6548
04:25:16,120 --> 04:25:17,720
NOTE. THE MASS OF DATA AND MUCH

6549
04:25:17,720 --> 04:25:20,040
OF THE DATA THAT MANY OF OUR

6550
04:25:20,040 --> 04:25:23,320
TRAINEES USE TO PLAN EXPERIMENTS

6551
04:25:23,320 --> 04:25:27,080
ARE NOT ONLY IN HIGH PROFILE

6552
04:25:27,080 --> 04:25:28,160
JOURNALS NOT ONLY NATURE SCIENCE

6553
04:25:28,160 --> 04:25:29,640
AND CELL, THEY ARE IN

6554
04:25:29,640 --> 04:25:34,640
PSYCHOPHARMACOLOGY. THEY ARE IN

6555
04:25:34,640 --> 04:25:36,640
NEUROPHARMACOLOGY, NEUROSCIENCE,

6556
04:25:36,640 --> 04:25:37,720
JOURNALS WHERE A PIECE OF DATA

6557
04:25:37,720 --> 04:25:39,040
CAN BE EXPLORED FULLY AND

6558
04:25:39,040 --> 04:25:43,480
PRESENTED FULLY.  THAT DOESN'T

6559
04:25:43,480 --> 04:25:44,880
COME INTO THE EQUATION WHEN WE

6560
04:25:44,880 --> 04:25:46,760
TALK ABOUT THE KINDS OF CASCADES

6561
04:25:46,760 --> 04:25:49,920
OF PUBLISHING YOU HEARD FROM

6562
04:25:49,920 --> 04:25:52,600
BODO. I THINK COALITION OF

6563
04:25:52,600 --> 04:25:55,440
SOCIETY PUBLISHERS WITH FUNDERS

6564
04:25:55,440 --> 04:25:57,080
WILL EXTREMELY WELCOME. I KNOW

6565
04:25:57,080 --> 04:25:58,680
THAT WELCOMES SOMETHING THAT

6566
04:25:58,680 --> 04:26:02,120
JOURNAL OF NEUROSCIENCE IN

6567
04:26:02,120 --> 04:26:04,120
SOCIETY FOR NEUROSCIENCE WILL

6568
04:26:04,120 --> 04:26:06,840
EMBRACE. I WANT TO AGAIN PRAISE

6569
04:26:06,840 --> 04:26:08,560
THE ERA COMMONS, IT WAS A

6570
04:26:08,560 --> 04:26:09,960
PIONEER IN ARCHIVING PUBLISHED

6571
04:26:09,960 --> 04:26:13,120
MATERIAL AND IT WAS REALLY ONE

6572
04:26:13,120 --> 04:26:15,320
OF THE FIRST TO DEMOCRATIZE

6573
04:26:15,320 --> 04:26:16,520
ACCESS TO SCIENTIFIC ARTICLES. 

6574
04:26:16,520 --> 04:26:18,440
I WAS IMPRESSED BY THE DATA

6575
04:26:18,440 --> 04:26:19,720
SHOWN ABOUT MILLIONS OF PAPERS

6576
04:26:19,720 --> 04:26:21,720
DOWNLOADED EACH DAY, I

6577
04:26:21,720 --> 04:26:22,720
DOWNLOADED ABOUT FIVE ARTICLES

6578
04:26:22,720 --> 04:26:24,400
TODAY FROM ERA COMMONS I CAN

6579
04:26:24,400 --> 04:26:25,600
TELL YOU IT'S FANTASTIC TO BE

6580
04:26:25,600 --> 04:26:27,720
ABLE TO PUSH A BUTTON IN PUBMED

6581
04:26:27,720 --> 04:26:29,400
AND GET THE CONTENT IMMEDIATELY

6582
04:26:29,400 --> 04:26:33,240
EVEN IF NOT ON THE UNIVERSITY

6583
04:26:33,240 --> 04:26:34,840
VPN. THE FACT IS THOUGH IT IS

6584
04:26:34,840 --> 04:26:36,640
ONLY PULLY PEER REVIEWED

6585
04:26:36,640 --> 04:26:38,640
CONTENT. SO THERE IS STILL A

6586
04:26:38,640 --> 04:26:41,600
DELAY BETWEEN THE TIME EVEN IF

6587
04:26:41,600 --> 04:26:43,800
IMMEDIATELY OPEN ACCESS UNDER

6588
04:26:43,800 --> 04:26:45,600
ERA COMMONS, STILL BETWEEN THE

6589
04:26:45,600 --> 04:26:47,040
TIME A SCIENTIST FINISHING THE

6590
04:26:47,040 --> 04:26:48,280
EXPERIMENT AND TIME IT WOULD BE

6591
04:26:48,280 --> 04:26:51,400
POSTED ON ERA COMMONS. I DON'T

6592
04:26:51,400 --> 04:26:52,600
THINK THAT WE SHOULD NECESSARILY

6593
04:26:52,600 --> 04:26:55,360
HAVE ONLY ONE WAY OF ARCHIVING.

6594
04:26:55,360 --> 04:26:59,160
WE SHOULD ARCHIVE FULLY PEER

6595
04:26:59,160 --> 04:27:01,480
REVIEWED STUDIES SEPARATELY FROM

6596
04:27:01,480 --> 04:27:03,600
NON-PEER REVIEWED STUDIES, THEY

6597
04:27:03,600 --> 04:27:04,480
HAVE DIFFERENT CONTENT AND THEY

6598
04:27:04,480 --> 04:27:07,240
SHOULD BE REGARDED DIFFERENTLY. 

6599
04:27:07,240 --> 04:27:09,560
I DO THINK ALSO THAT OPEN ACCESS

6600
04:27:09,560 --> 04:27:11,360
PUBLISHING POLICIES THAT ARE

6601
04:27:11,360 --> 04:27:13,440
BEING FLOATED DON'T SOLVE SOME

6602
04:27:13,440 --> 04:27:14,760
OF THE MAJOR PROBLEMS IN THE

6603
04:27:14,760 --> 04:27:17,120
SYSTEM INCLUDING THE MASSIVE

6604
04:27:17,120 --> 04:27:18,800
PROFITS AT LARGE COMMERCIAL

6605
04:27:18,800 --> 04:27:20,920
PUBLISHERS AND I DO THINK THAT

6606
04:27:20,920 --> 04:27:22,160
INCREASING CHOICE FOR AUTHORS

6607
04:27:22,160 --> 04:27:26,240
AND SUPPORTING IN INNOVATION FRM

6608
04:27:26,240 --> 04:27:27,920
eLIFE AND FUNDING BODIES SUCH

6609
04:27:27,920 --> 04:27:31,920
AS HHMI MADE A DIFFERENCE IN

6610
04:27:31,920 --> 04:27:33,160
WHAT IS THOUGHT TO BE

6611
04:27:33,160 --> 04:27:34,840
ACCEPTABLE. I THEN COMING

6612
04:27:34,840 --> 04:27:37,760
TOGETHER TO DO EXPERIMENTS IN

6613
04:27:37,760 --> 04:27:39,720
PEER REVIEW, IS SIGNISTTISES,

6614
04:27:39,720 --> 04:27:40,760
CONSIDER THESE EXPERIMENTS IN

6615
04:27:40,760 --> 04:27:41,680
PEER REVIEW NOT SIMPLY CHANGES

6616
04:27:41,680 --> 04:27:46,320
IN POLICY. IT IS AN IMPORTANT

6617
04:27:46,320 --> 04:27:47,800
THING FOR ALL OF US TO SUPPORT.

6618
04:27:47,800 --> 04:27:52,120
AND I WILL STOP THERE.

6619
04:27:52,120 --> 04:27:53,520
>> THANK YOU SO MUCH. THAT
WAS

6620
04:27:53,520 --> 04:27:54,360
REALLY HELP.

6621
04:27:54,360 --> 04:27:56,360
FUL AND GOT THOUGHTS FROM OUR

6622
04:27:56,360 --> 04:27:58,200
GUYS AND GALS SO GRATEFUL FOR

6623
04:27:58,200 --> 04:28:00,960
THAT. THANK YOU. SO UNLESS THERE

6624
04:28:00,960 --> 04:28:02,000
ARE CLARIFYING QUESTIONS, I'M

6625
04:28:02,000 --> 04:28:05,560
GOING TO TURN TO OUR FINAL

6626
04:28:05,560 --> 04:28:07,120
PRESENTER WE ARE GRATEFUL FOR

6627
04:28:07,120 --> 04:28:08,160
THE OPPORTUNITY TO HEAR FROM ONE

6628
04:28:08,160 --> 04:28:10,160
OF OUR COUNCIL MEMBERS ON THIS

6629
04:28:10,160 --> 04:28:13,440
TOPIC DR. EKEMINI RILEY. WHO IS

6630
04:28:13,440 --> 04:28:14,360
MANAGING DIRECTOR ALIGNING

6631
04:28:14,360 --> 04:28:17,880
SCIENCE ACROSS PARKINSONS OR

6632
04:28:17,880 --> 04:28:19,800
ASAP. IT IS A RESEARCH FUNDING

6633
04:28:19,800 --> 04:28:21,080
KNISHTIVE ACCELERATING THE PACE

6634
04:28:21,080 --> 04:28:22,200
OF DISCOVERY AND INFORMING PATH

6635
04:28:22,200 --> 04:28:25,240
TO CURE FOR PARKINSONS. THROUGH

6636
04:28:25,240 --> 04:28:26,400
COLLABORATION RESEARCH ENABLING

6637
04:28:26,400 --> 04:28:27,840
RESOURCES AND DATA SHARING PRIOR

6638
04:28:27,840 --> 04:28:30,320
TO HER ROLE IN ASAP SHE WAS

6639
04:28:30,320 --> 04:28:31,760
DIRECTOR AT THE -- INSTITUTE

6640
04:28:31,760 --> 04:28:33,360
CENTER FOR STRATEGIC

6641
04:28:33,360 --> 04:28:34,520
PHILANTHROPY AND BELOOK FORWARD

6642
04:28:34,520 --> 04:28:37,760
TO HEARING HER COMMENTS ON ASAP

6643
04:28:37,760 --> 04:28:38,800
EXPERIENCE DEVELOPING

6644
04:28:38,800 --> 04:28:40,560
IMPLEMENTING OPEN ACCESS POLICY 

6645
04:28:40,560 --> 04:28:43,040
>> THANKS, AMY. I DON'T
HAVE TO

6646
04:28:43,040 --> 04:28:44,040
GO OVER OUR MISSION BECAUSE YOU

6647
04:28:44,040 --> 04:28:46,800
JUST COVERED IT BUT I WILL SAY

6648
04:28:46,800 --> 04:28:49,960
THAT AS Y'ALL HEARD, OPEN

6649
04:28:49,960 --> 04:28:51,400
SCIENCE IS CORE TO OUR

6650
04:28:51,400 --> 04:28:54,880
INITIATIVE. WE ARE AS BODO

6651
04:28:54,880 --> 04:28:56,400
MENTIONED A COALITION MEMBER AND

6652
04:28:56,400 --> 04:28:57,200
WE IMPLEMENT SOME OF THE

6653
04:28:57,200 --> 04:29:01,040
POLICIES THAT THEY HAVE

6654
04:29:01,040 --> 04:29:02,480
PIONEERED IN PART SO I WILL

6655
04:29:02,480 --> 04:29:04,200
EXPLAIN IN A MOMENT. SO JUST TO

6656
04:29:04,200 --> 04:29:07,480
START OFF, I WILL GO THROUGH OUR

6657
04:29:07,480 --> 04:29:09,360
FIVE POINT OPEN SCIENCE POLICY,

6658
04:29:09,360 --> 04:29:11,440
AND I WILL DESCRIBE WHY WE REFER

6659
04:29:11,440 --> 04:29:13,200
TO IT AS OPEN SCIENCE POLICY IN

6660
04:29:13,200 --> 04:29:14,760
A MOMENT BECAUSE IT IS MORE THAN

6661
04:29:14,760 --> 04:29:16,600
JUST THE ACTUAL PUBLICATION WE

6662
04:29:16,600 --> 04:29:19,680
CARE ABOUT. SO FIRST AND

6663
04:29:19,680 --> 04:29:20,680
FOREMOST WE MANDATE A PRE-PRINT

6664
04:29:20,680 --> 04:29:24,080
FROM ALL OF OUR RESEARCH NETWORK

6665
04:29:24,080 --> 04:29:25,560
MEMBERS SO WE OPERATE WHAT WE

6666
04:29:25,560 --> 04:29:28,840
CALL THE COLLABORATIVE RESEARCH

6667
04:29:28,840 --> 04:29:31,480
NETWORK, WE HAVE 160

6668
04:29:31,480 --> 04:29:33,120
INVESTIGATORS LEADING VARIOUS

6669
04:29:33,120 --> 04:29:36,520
TEAMS, 35 TEAMS IN THAT NETWORK.

6670
04:29:36,520 --> 04:29:37,640
AND SO OUR OPEN SCIENCE POLICY

6671
04:29:37,640 --> 04:29:38,760
IS MEANT TO PROMOTE SHARING

6672
04:29:38,760 --> 04:29:40,560
WITHIN THE NETWORK AND THEN

6673
04:29:40,560 --> 04:29:41,640
MANAGE THAT SHARING TO OUTSIDE

6674
04:29:41,640 --> 04:29:45,920
OF THE NETWORK TO THE PUBLIC. SO

6675
04:29:45,920 --> 04:29:48,800
WITH THAT, WE ALSO REQUIRE OUR

6676
04:29:48,800 --> 04:29:50,480
GRANTEES TO HAVE FREE ONLINE

6677
04:29:50,480 --> 04:29:54,040
ACCESS UPON PUBLICATION WITH A

6678
04:29:54,040 --> 04:29:55,400
CCBY LICENSE FOR UNRESTRICTED

6679
04:29:55,400 --> 04:29:57,480
USE. FROM THERE WE ALSO REQUIRE

6680
04:29:57,480 --> 04:29:59,200
THAT ALL RESEARCH OUTPUTS THAT

6681
04:29:59,200 --> 04:30:00,480
ARE ASSOCIATED WITH THE

6682
04:30:00,480 --> 04:30:02,120
MANUSCRIPT SO THE DATA, THE

6683
04:30:02,120 --> 04:30:03,400
PROTOCOLS, CODE, WHAT HAVE YOU,

6684
04:30:03,400 --> 04:30:07,440
ARE DEPOSITED IN PUBLICLY

6685
04:30:07,440 --> 04:30:08,200
ACCESSIBLE REPOSITORIES AND IN

6686
04:30:08,200 --> 04:30:10,120
THE ePUBLICATION WITH

6687
04:30:10,120 --> 04:30:14,360
PERMANENT IDENTIFIER. THE FOURTH

6688
04:30:14,360 --> 04:30:15,400
IS APPROPRIATE ATTRIBUTIONS TO

6689
04:30:15,400 --> 04:30:17,280
ASAP FUNDED WORK AND THE LAST

6690
04:30:17,280 --> 04:30:19,360
BIG ONE IS USING OUR RESEARCH

6691
04:30:19,360 --> 04:30:21,800
OUTPUT MANAGEMENT SYSTEM, THIS

6692
04:30:21,800 --> 04:30:24,160
TRACKS RESEARCH OUTPUTS THAT ARE

6693
04:30:24,160 --> 04:30:26,560
GENERATED BY OUR GRANTEES ON THE

6694
04:30:26,560 --> 04:30:29,600
PLATFORM AND ALSO HIMSELF INFORM

6695
04:30:29,600 --> 04:30:30,880
WHEN -- HELPS INFORM WHEN

6696
04:30:30,880 --> 04:30:33,160
RESOURCES ARE MADE AVAILABLE AND

6697
04:30:33,160 --> 04:30:34,480
ALSO HELPS GRANTEES BE ABLE TO

6698
04:30:34,480 --> 04:30:36,760
CONNECT WITH EACH OTHER AND FIND

6699
04:30:36,760 --> 04:30:44,080
THOSE MATERIALS. BODO MENTIONED

6700
04:30:44,080 --> 04:30:45,520
HHMI DOESN'T COVER ARTICLE

6701
04:30:45,520 --> 04:30:46,720
PROCESSING FEES THAT IS WHERE WE

6702
04:30:46,720 --> 04:30:48,560
DIFFER. WE DO COVER ARTICLE

6703
04:30:48,560 --> 04:30:52,800
PROCESSING FEES FOR OUR GRANTEES

6704
04:30:52,800 --> 04:30:55,360
ONE DIFFER IN TERMS OF

6705
04:30:55,360 --> 04:30:56,440
IMPLEMENTING THE PLAN STRATEGY

6706
04:30:56,440 --> 04:31:01,560
IS THAT WE CARE THE ARTICLE IS

6707
04:31:01,560 --> 04:31:02,720
ACCESSIBLE UPON PLOYCATION SO WE

6708
04:31:02,720 --> 04:31:09,080
ALLOW OUR GRANTEES TO PUBLISH IN

6709
04:31:09,080 --> 04:31:10,160
HYBRID YOUR HONOROR JOURNALS AND

6710
04:31:10,160 --> 04:31:11,200
GOLD OPEN ACCESS JOURNALS.  IN

6711
04:31:11,200 --> 04:31:12,360
CONSIDERING THE PRINCIPLES FOR

6712
04:31:12,360 --> 04:31:14,680
OUR INITIATIVE TRY TO UNDERSTAND

6713
04:31:14,680 --> 04:31:16,880
WHY BOTH OPEN ACCESS AND OPEN

6714
04:31:16,880 --> 04:31:19,520
SCIENCE ARE CORE TO OUR

6715
04:31:19,520 --> 04:31:21,320
INITIATIVE. ONE SITES IS BASED

6716
04:31:21,320 --> 04:31:23,320
ON COLLABORATION. IN ORDER TO

6717
04:31:23,320 --> 04:31:24,480
BUILD UPON PEOPLE WORK YOU HAVE

6718
04:31:24,480 --> 04:31:26,360
TO FIND IT HAVE TO USE IT. AND

6719
04:31:26,360 --> 04:31:28,480
WE BELIEVE PEOPLE SHOULD FIND BE

6720
04:31:28,480 --> 04:31:30,280
ABLE TO FIND THAT WITHOUT PAY

6721
04:31:30,280 --> 04:31:33,320
WALLS. THE NEXT THING IS THAT WE

6722
04:31:33,320 --> 04:31:34,720
BELIEVE SCIENCE TO FUNCTION

6723
04:31:34,720 --> 04:31:37,440
EFFECTIVELY, IT IS CRUCIAL THAT

6724
04:31:37,440 --> 04:31:39,120
THAT SCIENCE AND DATA UNDERLYING

6725
04:31:39,120 --> 04:31:42,000
ARE MADE OPEN. AND THEN WE ALSO

6726
04:31:42,000 --> 04:31:43,480
FEEL THE ULTIMATE VALUE OF THE

6727
04:31:43,480 --> 04:31:45,760
DATA CAN'T BE PREDICTED.  SO

6728
04:31:45,760 --> 04:31:49,000
THUS BY HAVING IT OPEN YOU ALLOW

6729
04:31:49,000 --> 04:31:50,760
OTHERS TO REANALYZE THE DATA,

6730
04:31:50,760 --> 04:31:52,120
GAIN NEW INSIGHT AND BE ABLE TO

6731
04:31:52,120 --> 04:31:58,800
INNOVATE ON WHAT YOU HAVE FOUND 

6732
04:31:58,800 --> 04:32:00,080
WE LAUNCHED THE INITIATIVE BACK

6733
04:32:00,080 --> 04:32:03,760
IN 2019, GRANTED OUR FIRST

6734
04:32:03,760 --> 04:32:07,280
GRANTS CRN IN 2020. AND SINCE

6735
04:32:07,280 --> 04:32:09,720
THEN WE HAVE SEEN THE LANDSCAPE

6736
04:32:09,720 --> 04:32:12,480
OR OPEN SCIENCE EVOLVING, WE

6737
04:32:12,480 --> 04:32:14,080
LEARN NEXT YEAR NIH IS GOING TO

6738
04:32:14,080 --> 04:32:16,400
REQUIRE ALL THE RESEARCHERS TO

6739
04:32:16,400 --> 04:32:18,160
INCLUDE DATA MANAGEMENT PLAN AND

6740
04:32:18,160 --> 04:32:19,600
THEIR GRANT APPLICATIONS, WE

6741
04:32:19,600 --> 04:32:21,520
HAVE LEARNED THAT NASA WILL HAVE

6742
04:32:21,520 --> 04:32:24,360
THEIR YEAR OF OPEN SCIENCE NEXT

6743
04:32:24,360 --> 04:32:27,200
YEAR. NATIONAL SCIENCE AND

6744
04:32:27,200 --> 04:32:28,440
TECHNOLOGY COUNCIL SERVED ABOUT

6745
04:32:28,440 --> 04:32:29,960
GUIDANCE AND IMPLEMENTING THE

6746
04:32:29,960 --> 04:32:33,120
NATIONAL SECURITY MEMORANDUM.

6747
04:32:33,120 --> 04:32:34,800
WHICH NECESSITATES THE USE OF

6748
04:32:34,800 --> 04:32:36,680
PERSISTENT IDENTIFIERS AND

6749
04:32:36,680 --> 04:32:42,240
PERSON IDs LIKE THE ORCHID. WE

6750
04:32:42,240 --> 04:32:44,160
KNOW NATIONAL ACADEMIES CONVENE

6751
04:32:44,160 --> 04:32:45,880
A ROUND TABLE FOR OPEN SCIENCE,

6752
04:32:45,880 --> 04:32:47,280
THEY RELEASED THEIR TOOL KIT FOR

6753
04:32:47,280 --> 04:32:50,880
POST FOSTERING OPEN SCIENCE

6754
04:32:50,880 --> 04:32:53,960
PRACTICES WHICH WE WERE HAPPY TO

6755
04:32:53,960 --> 04:32:55,400
CONTRIBUTE TO AND GLOBAL FOCUS

6756
04:32:55,400 --> 04:32:56,440
ON OPEN SCIENCE CONTINUES TO

6757
04:32:56,440 --> 04:32:58,840
GROW, WE HAVE SEEN THE UNESCO

6758
04:32:58,840 --> 04:33:00,480
BUILDING AND OPEN EXTENSIVE

6759
04:33:00,480 --> 04:33:01,840
NETWORK OF PARTNERS THAT

6760
04:33:01,840 --> 04:33:03,800
INCLUDES BROAD STAKEHOLDERS WHO

6761
04:33:03,800 --> 04:33:04,560
ARE IMPLEMENTING OPEN SCIENCE

6762
04:33:04,560 --> 04:33:10,360
PRACTICES. I MENTIONED OPEN

6763
04:33:10,360 --> 04:33:11,440
SCIENCE AT THAT TIME TOP AND IT

6764
04:33:11,440 --> 04:33:13,320
WAS MORE INCLUSIVE THAN JUST THE

6765
04:33:13,320 --> 04:33:17,000
ACTUAL PUBLICATION ITSELF.  WHAT

6766
04:33:17,000 --> 04:33:19,360
RESONATES WITH US IS EUROPEAN

6767
04:33:19,360 --> 04:33:20,840
COMMISSION DEFINITION WHEREBY

6768
04:33:20,840 --> 04:33:21,360
OPEN SCIENCE MEANS YOU ARE

6769
04:33:21,360 --> 04:33:24,200
TAKING A NEW APPROACH TO

6770
04:33:24,200 --> 04:33:26,000
SCIENTIFIC PROCESS BASED ON

6771
04:33:26,000 --> 04:33:27,320
COOPERATIVE WORK AND NEW WAYS

6772
04:33:27,320 --> 04:33:29,160
DIFFUSING BY USING DIGITAL

6773
04:33:29,160 --> 04:33:30,640
TECHNOLOGIES AND COLLABORATIVE

6774
04:33:30,640 --> 04:33:32,200
TOOLS WHICH IS A SIMPLE

6775
04:33:32,200 --> 04:33:34,240
DEFINITION FOR US TO RALLY

6776
04:33:34,240 --> 04:33:37,360
AROUND. AND SO AS WE THINK ABOUT

6777
04:33:37,360 --> 04:33:39,360
OPEN SCIENCE AND EXTENDS THE

6778
04:33:39,360 --> 04:33:42,040
PRINCIPLES OF OPENNESS TO THE

6779
04:33:42,040 --> 04:33:43,080
WHOLE RESEARCH LIFE CYCLE

6780
04:33:43,080 --> 04:33:44,800
OPPOSED TO JUST THE ARTICLE

6781
04:33:44,800 --> 04:33:46,640
ITSELF.  THESE ARE THINGS WE SEE

6782
04:33:46,640 --> 04:33:48,040
IN OUR INITIATIVE AS WELL. SO

6783
04:33:48,040 --> 04:33:51,080
THE POINT OF DATA COLLECTION,

6784
04:33:51,080 --> 04:33:53,280
URGE CLARIFY USAGE RIGHTS TO

6785
04:33:53,280 --> 04:33:56,480
THAT DATA. DATA PROCESSING, WE

6786
04:33:56,480 --> 04:33:59,320
DO MANDATE THAT OUR

6787
04:33:59,320 --> 04:34:00,080
INVESTIGATORS UTILIZE OPEN

6788
04:34:00,080 --> 04:34:01,920
SOURCE SOFTWARE INTERFACE AT THE

6789
04:34:01,920 --> 04:34:04,760
VERY LEAST IT IS FINDSABLE. IN

6790
04:34:04,760 --> 04:34:06,760
TERMS OF STORING DATA AND

6791
04:34:06,760 --> 04:34:08,360
RESULTS WE REQUIRE THAT OUR

6792
04:34:08,360 --> 04:34:10,040
GRANTEES USE PERSISTENT

6793
04:34:10,040 --> 04:34:12,000
IDENTIFIERS SO THAT THE LINKS TO

6794
04:34:12,000 --> 04:34:14,360
THAT DATA ARE ALWAYS AROUND.  NO

6795
04:34:14,360 --> 04:34:15,600
MATTER WHAT ELSE MAY CHANGE

6796
04:34:15,600 --> 04:34:18,960
AROUND THE LINKS TO THAT DATA.

6797
04:34:18,960 --> 04:34:20,600
AND ALSO INCLUDE DESCRIPTIVE

6798
04:34:20,600 --> 04:34:21,960
METADATA USING THE STANDARDS FOR

6799
04:34:21,960 --> 04:34:23,960
YOUR FIELD SO THAT IT CAN BE

6800
04:34:23,960 --> 04:34:24,880
CONTEXTUALIZED BY OTHERS WHO

6801
04:34:24,880 --> 04:34:27,200
FIND THE DATA.  NEXT ON THE

6802
04:34:27,200 --> 04:34:27,920
PUBLICATION AND DISTRIBUTION

6803
04:34:27,920 --> 04:34:29,520
ASPECT OF THINGS, AGAIN,

6804
04:34:29,520 --> 04:34:31,360
PUBLISHING THE ARTICLE OPEN

6805
04:34:31,360 --> 04:34:32,720
ACCESS, WE REQUIRE TO BE

6806
04:34:32,720 --> 04:34:34,400
IMMEDIATE, AGAIN WE ALLOW BOTH

6807
04:34:34,400 --> 04:34:37,480
HYBRID AND GOLD STANDARD OPEN

6808
04:34:37,480 --> 04:34:40,360
ACCESS JOURNALS, ENSURING THE

6809
04:34:40,360 --> 04:34:42,360
LINKS BETWEEN PUBLICATION DATA

6810
04:34:42,360 --> 04:34:43,840
CODE AND METHODS ARE SEAMLESSLY

6811
04:34:43,840 --> 04:34:45,880
INCLUDED WITHIN THE PAPER. ONE

6812
04:34:45,880 --> 04:34:48,400
THING I WILL NOTE, WE HAVE

6813
04:34:48,400 --> 04:34:50,280
PARTNERSHIPS WITH PROTOCOLS AT

6814
04:34:50,280 --> 04:34:51,960
IO AND REQUIRE ALL PROTOCOLS USE

6815
04:34:51,960 --> 04:34:55,480
IN THE PAPERS ARE ON AN OPEN

6816
04:34:55,480 --> 04:34:56,920
PLATFORM AND CAN BE REFERRED TO

6817
04:34:56,920 --> 04:34:59,280
AS THROUGH PERSISTENT LINK. WE

6818
04:34:59,280 --> 04:35:01,240
ENCOURAGE THE USE OF PUBLICLY

6819
04:35:01,240 --> 04:35:02,800
AVAILABLE REPOSITORIES AN THOSE

6820
04:35:02,800 --> 04:35:04,040
LINKS BE INCLUDED IN THE PAPER

6821
04:35:04,040 --> 04:35:06,840
AT TIME OF PUBLICATION. AND

6822
04:35:06,840 --> 04:35:08,040
AGAIN PUBLISHING METADATA WITH

6823
04:35:08,040 --> 04:35:11,360
AN OPEN LICENSE. AND THEN AFTER

6824
04:35:11,360 --> 04:35:15,360
DOING ALL THIS WE SEE AND

6825
04:35:15,360 --> 04:35:17,160
BELIEVE VERY HEARTLY THIS

6826
04:35:17,160 --> 04:35:19,920
PROMOTES REUSE OF RESOURCES DATA

6827
04:35:19,920 --> 04:35:22,320
THAT PRESENTED IN ARTICLES,

6828
04:35:22,320 --> 04:35:23,360
ENSURING THAT YOU HAVE CLEAR

6829
04:35:23,360 --> 04:35:25,360
CITATIONS TO BE ABLE TO DO SO

6830
04:35:25,360 --> 04:35:27,280
AND ENSURING THE ACCUMULATION OF

6831
04:35:27,280 --> 04:35:29,320
CREDIT AT ALL ASPECTS OF THIS AS

6832
04:35:29,320 --> 04:35:31,200
WE START WORKING WITH FOLKS WHO

6833
04:35:31,200 --> 04:35:35,040
ARE MORE IN THE DATA SPHERE

6834
04:35:35,040 --> 04:35:36,520
THERE ARE MORE THINGS

6835
04:35:36,520 --> 04:35:37,640
INVESTIGATORS SHOULD BE GETTING

6836
04:35:37,640 --> 04:35:40,400
CREDIT FOR OUTSIDE OF JUST THE

6837
04:35:40,400 --> 04:35:41,680
ACTUAL PUBLICATION OF CELL, THE

6838
04:35:41,680 --> 04:35:45,720
DATA IS REALLY IMPORTANT. SO IN

6839
04:35:45,720 --> 04:35:49,280
TERMS OF HOW WE ARE DOING, BACK

6840
04:35:49,280 --> 04:35:50,560
IN MARCH WE DID THIS ANALYSIS

6841
04:35:50,560 --> 04:35:53,360
AND AT THE TIME WE HAD 37

6842
04:35:53,360 --> 04:35:55,000
PREPRINTS, JUST CHECKED OUR

6843
04:35:55,000 --> 04:35:56,280
CHANNEL BEFORE IT PRESENTED AND

6844
04:35:56,280 --> 04:35:58,400
WE ARE UP TO 46 AT THIS POINT

6845
04:35:58,400 --> 04:36:00,040
WHICH LED TO 26 ORIGINAL

6846
04:36:00,040 --> 04:36:02,440
RESEARCH PUBLICATIONS. WE DO

6847
04:36:02,440 --> 04:36:05,680
HAVE A CHANNEL ON BIOARCHIVE

6848
04:36:05,680 --> 04:36:07,040
WHERE WE COLLATE ALL THE

6849
04:36:07,040 --> 04:36:08,440
PRE-PRINTS THAT COME IN FOR

6850
04:36:08,440 --> 04:36:09,880
INITIATIVE AND WE ARE SEEING

6851
04:36:09,880 --> 04:36:11,920
THAT PREPRINTS ARE POSTED ON

6852
04:36:11,920 --> 04:36:13,280
AVERAGE FIVE AND A HALF MONTHS

6853
04:36:13,280 --> 04:36:15,400
BEFORE FINAL PUBLICATION IS READ

6854
04:36:15,400 --> 04:36:18,240
AVAILABLE. -- MADE AVAILABLE.

6855
04:36:18,240 --> 04:36:19,240
ONE THING WE DO WITH THE

6856
04:36:19,240 --> 04:36:21,640
MANDATORY PRE-PRINT IS WE USE IT

6857
04:36:21,640 --> 04:36:23,360
AS A TRAINING WHEELS.  THERE IS

6858
04:36:23,360 --> 04:36:28,360
A LOT IN THE OPEN SCIENCE SPHERE

6859
04:36:28,360 --> 04:36:30,280
TO HAVE TO FIND, SEAT AND

6860
04:36:30,280 --> 04:36:31,840
IMPLEMENT. SO WE TRY TO LOWER

6861
04:36:31,840 --> 04:36:33,920
THAT BARRIER FOR OUR GRANTEES BY

6862
04:36:33,920 --> 04:36:35,440
PROVIDING A NUMBER OF RESOURCES

6863
04:36:35,440 --> 04:36:37,800
BUT ALSO CHECKING COMPLIANCE

6864
04:36:37,800 --> 04:36:40,080
ALONG THE WAY TO ENSURE ONE,

6865
04:36:40,080 --> 04:36:41,720
THAT THEY ARE COMPLIANT WITH

6866
04:36:41,720 --> 04:36:45,920
POLICIES SET IN PLACE BUT TWO WE

6867
04:36:45,920 --> 04:36:46,840
KNOW MOST VISITORS THOSE WITHIN

6868
04:36:46,840 --> 04:36:48,720
OUR INITIATIVE WANT TO COMPLY

6869
04:36:48,720 --> 04:36:50,960
WITH ALL OF THE RULES. SO WE

6870
04:36:50,960 --> 04:36:53,960
WANT TO MAKE THAT EASY. SO START

6871
04:36:53,960 --> 04:36:54,960
WITH PRE-PRINT AND DO A

6872
04:36:54,960 --> 04:36:56,800
COMPLIANCE CHECK TO UNDERSTAND

6873
04:36:56,800 --> 04:36:58,120
AT ALL THE PLACES YOU SEE HERE

6874
04:36:58,120 --> 04:37:00,520
IN THE CIRCLE, WHAT HAS BEEN

6875
04:37:00,520 --> 04:37:01,480
DONE AND WHAT STILL NEEDS TO BE

6876
04:37:01,480 --> 04:37:03,440
DONE BEFORE THE FINAL PAPER IS

6877
04:37:03,440 --> 04:37:05,160
PUBLISHED. SO WHAT WE HAVE SEEN

6878
04:37:05,160 --> 04:37:08,240
IS WE REVIEW BEFOREHAND, THIS IS

6879
04:37:08,240 --> 04:37:10,000
GROUND ZERO. AND THEN ONCE THE

6880
04:37:10,000 --> 04:37:12,160
ACTUAL PUBLICATION IS DONE WE

6881
04:37:12,160 --> 04:37:13,800
SEE COMPLIANCE ACROSS THE BOARD

6882
04:37:13,800 --> 04:37:15,280
AT DIFFERENT PARTS OF THIS

6883
04:37:15,280 --> 04:37:17,360
PROPELLER. SO I THINK WE HAVE

6884
04:37:17,360 --> 04:37:20,480
SET UP AND TAKEN ABOUT A YEAR TO

6885
04:37:20,480 --> 04:37:22,240
SET UP A SMOOTH COMPLIANCE

6886
04:37:22,240 --> 04:37:24,480
PATHWAY, WE HAVE PARTNERED WITH

6887
04:37:24,480 --> 04:37:26,360
DATA TO BE ABLE TO DO THAT TO

6888
04:37:26,360 --> 04:37:28,280
AUTOMATE M&A THAT PROCESS SO

6889
04:37:28,280 --> 04:37:29,560
EVERYTHING FROM CHECKING THE

6890
04:37:29,560 --> 04:37:32,640
PROTOCOLS, CHECKING CITATIONS,

6891
04:37:32,640 --> 04:37:34,440
DOING WORD SEARCHES TO FIND

6892
04:37:34,440 --> 04:37:35,280
WHERE DIFFERENT RESOURCES ARE

6893
04:37:35,280 --> 04:37:36,400
MENTIONED AND ENSURING THAT

6894
04:37:36,400 --> 04:37:37,640
THERE ARE IDENTIFIERS THAT ARE

6895
04:37:37,640 --> 04:37:41,040
ATTACHED TO THOSE THINGS. THE

6896
04:37:41,040 --> 04:37:43,680
LAST POINT I MENTION WE HAVE

6897
04:37:43,680 --> 04:37:44,880
RESEARCH OUTPUT MANAGEMENT

6898
04:37:44,880 --> 04:37:46,360
SYSTEM THIS IS PART OF THE

6899
04:37:46,360 --> 04:37:47,680
BROADER OPEN SCIENCE LANDSCAPE

6900
04:37:47,680 --> 04:37:49,400
TRYING TO SET UP AND THIS IS A

6901
04:37:49,400 --> 04:37:52,560
PLACE WHERE ALL GRANTEES HAVE

6902
04:37:52,560 --> 04:37:54,720
ALL INFORMATION WITHIN THIS

6903
04:37:54,720 --> 04:37:55,520
PLATFORM EVERYTHING FROM

6904
04:37:55,520 --> 04:37:57,920
PROPOSAL THEY SUBMITTED WHICH IS

6905
04:37:57,920 --> 04:37:59,480
OPEN AND PUBLISHED FOR EVERYONE

6906
04:37:59,480 --> 04:38:01,800
WITHIN NETWORK TO SEE TO EVERY

6907
04:38:01,800 --> 04:38:02,800
PROGRESS REPORT TO RESOURCES

6908
04:38:02,800 --> 04:38:07,120
THAT ARE GENERATED, SO PEOPLE

6909
04:38:07,120 --> 04:38:08,960
WITHIN THE RESEARCH NETWORK HAVE

6910
04:38:08,960 --> 04:38:10,600
EARLY ACCESS TO RESOURCES AND

6911
04:38:10,600 --> 04:38:11,760
BEKNOW WHEN THOSE RESOURCES ARE

6912
04:38:11,760 --> 04:38:13,640
MADE PUBLIC AND PUT INTO PUBLIC

6913
04:38:13,640 --> 04:38:17,920
REPOSITORY. IN TERMS OF THINGS

6914
04:38:17,920 --> 04:38:21,720
LOGGED SO FAR IN OUR OUTPUT

6915
04:38:21,720 --> 04:38:22,560
MANAGEMENT SYSTEM, EVERYTHING

6916
04:38:22,560 --> 04:38:24,280
FROM PROTOCOLS TO ANIMAL MODELS

6917
04:38:24,280 --> 04:38:25,360
BIOINFORMATICS TOOLS AND

6918
04:38:25,360 --> 04:38:28,680
COLLATED IN HERE, WITH THE GOAL

6919
04:38:28,680 --> 04:38:30,480
SOME POINT ALL THESE RESOURCES

6920
04:38:30,480 --> 04:38:32,320
MADE AVAILABLE TO THE BROADER

6921
04:38:32,320 --> 04:38:35,200
NEUROSCIENCE COMMUNITY. AND SO

6922
04:38:35,200 --> 04:38:36,920
AS WE THINK ABOUT OPEN SCIENCE

6923
04:38:36,920 --> 04:38:38,200
HOW WE ARE IMPLEMENTING IT IF IT

6924
04:38:38,200 --> 04:38:39,920
IS WORKING, THERE IS A THREE

6925
04:38:39,920 --> 04:38:41,600
MAIN BUCKETS THAT WE ARE

6926
04:38:41,600 --> 04:38:42,600
THINKING ABOUT ASSESSING OVER

6927
04:38:42,600 --> 04:38:45,600
THE NEXT FIVE TO SEVEN YEARS.

6928
04:38:45,600 --> 04:38:47,280
ONE IS ARE RESOURCES FINDABLE

6929
04:38:47,280 --> 04:38:51,320
AND ACCESSIBLE BY THE BROADER

6930
04:38:51,320 --> 04:38:53,840
PUBLIC NEXT ARE WE ACCELERATING

6931
04:38:53,840 --> 04:38:55,480
DISCOVERY, YOU WILL HEAR THE SUB

6932
04:38:55,480 --> 04:38:57,480
BULLET POINTS ARE METRICS WE ARE

6933
04:38:57,480 --> 04:38:58,520
USING TO GAUGE ANSWERS TO THESE

6934
04:38:58,520 --> 04:39:02,000
QUESTIONS.  AND LAST PIECE, ARE

6935
04:39:02,000 --> 04:39:03,680
WE HELPING TO CHANGE CULTURE OF

6936
04:39:03,680 --> 04:39:06,600
OPEN SCIENCE WHICH AGAIN IS OUR

6937
04:39:06,600 --> 04:39:08,160
GOAL LIEU THIS INITIATIVE. I

6938
04:39:08,160 --> 04:39:09,360
KNOW WE ARE SHORT ON TIME, I'M

6939
04:39:09,360 --> 04:39:10,720
GOING TO STOP THERE AND OPEN UP

6940
04:39:10,720 --> 04:39:15,320
FOR DISCUSSION. 

6941
04:39:15,320 --> 04:39:16,120
>> THANK YOU VERY MUCH,
THAT WAS

6942
04:39:16,120 --> 04:39:17,160
GREAT. I HAVE TO SAY THIS PANEL

6943
04:39:17,160 --> 04:39:18,960
IS EXTRAORDINARY AND I'M

6944
04:39:18,960 --> 04:39:20,520
GRATEFUL FOR EVERYONE TAKING THE

6945
04:39:20,520 --> 04:39:21,880
TIME TO COME PARTICIPATE IN THIS

6946
04:39:21,880 --> 04:39:24,240
DISCUSSION. WE DO HAVE TIME FOR

6947
04:39:24,240 --> 04:39:25,680
A COUPLE OF QUESTIONS AND I

6948
04:39:25,680 --> 04:39:28,520
WOULD REALLY LOVE TO HEAR FROM

6949
04:39:28,520 --> 04:39:30,960
FOLKS. SO LET ME KNOW.

6950
04:39:30,960 --> 04:39:34,080
>> I HAD QUESTION FOR ANY

6951
04:39:34,080 --> 04:39:35,480
EXPERTS. REVIEW OF COMMONS

6952
04:39:35,480 --> 04:39:37,800
LAUNCHED A AS WAY SORT OF

6953
04:39:37,800 --> 04:39:41,480
INDEPENDENTLY GETTING REVIEWED,

6954
04:39:41,480 --> 04:39:42,560
ANYBODY KNOW BUSINESS MODEL FOR

6955
04:39:42,560 --> 04:39:45,400
REVIEW OF COMMONS IS, HOW IS

6956
04:39:45,400 --> 04:39:47,720
THAT PAID FOR, YOU BROUGHT UP

6957
04:39:47,720 --> 04:39:48,840
THE EXCELLENT POINT, REAL COST

6958
04:39:48,840 --> 04:39:50,400
IS MANAGING THE PROCESS OF

6959
04:39:50,400 --> 04:39:51,840
HOUNDING PEOPLE LIKE ME TO GET

6960
04:39:51,840 --> 04:39:53,560
REVIEWS DONE AND INVITING US TO

6961
04:39:53,560 --> 04:39:56,960
DO IT.  AND I HAVE REVIEWED

6962
04:39:56,960 --> 04:40:00,040
COMMENTS BUT I NEVER OCCURRED TO

6963
04:40:00,040 --> 04:40:03,280
ME SOMEONE FOOTING THIS BILL BUT

6964
04:40:03,280 --> 04:40:07,600
I DON'T KNOW WHO IT IS.

6965
04:40:07,600 --> 04:40:08,800
>> I DIDN'T HAVE ANYTHING
TO

6966
04:40:08,800 --> 04:40:10,600
SAY. I WAS JUST SHAKING MY HEAD 

6967
04:40:10,600 --> 04:40:13,120
>> I CAN SAY I MEAN THIS
IS

6968
04:40:13,120 --> 04:40:14,400
EXACTLY WHAT IS MISSING RIGHT

6969
04:40:14,400 --> 04:40:19,160
NOW. AT THE MOMENT ALL THESE

6970
04:40:19,160 --> 04:40:23,320
REVIEW SERVICES ARE SUPPORTED BY

6971
04:40:23,320 --> 04:40:25,120
PHILANTHROPY ORGANIZATIONS. AND

6972
04:40:25,120 --> 04:40:26,920
OF COURSE IF WE WANT TO CHANGE

6973
04:40:26,920 --> 04:40:28,640
THAT, WE WOULD HAVE FIGURE OUT

6974
04:40:28,640 --> 04:40:33,680
HOW WE ARE PAYING FOR -- I AGREE

6975
04:40:33,680 --> 04:40:35,080
WITH WHAT MARINA SAID.  WE ARE

6976
04:40:35,080 --> 04:40:37,360
NOT ADVOCATING THAT IT SHOULD BE

6977
04:40:37,360 --> 04:40:40,200
JUST FREE FALL PEOPLE COMMENT ON

6978
04:40:40,200 --> 04:40:41,520
BIOARCHIVE. THAT CAN BE PART OF

6979
04:40:41,520 --> 04:40:44,040
IT BUT IT NEW EVIDENCE TO BE AN

6980
04:40:44,040 --> 04:40:44,680
ORGANIZED PEER REEVED PROCESS

6981
04:40:44,680 --> 04:40:46,320
WITHIN THE AGENCY AND THAT NEEDS

6982
04:40:46,320 --> 04:40:50,160
TO BE PAID FOR. WE ARE PAYING

6983
04:40:50,160 --> 04:40:51,680
FOR PUBLICATION AT THE END AND

6984
04:40:51,680 --> 04:40:55,120
QUITE A LOT OF IT.  THERE SHOULD

6985
04:40:55,120 --> 04:40:58,200
BE SMART WAYS OF SHIFTING MONEY

6986
04:40:58,200 --> 04:41:01,240
TO -- SO THAT WE CAN FUND

6987
04:41:01,240 --> 04:41:06,040
PRE-PRINT REVIEW.  WHERE CURRENT

6988
04:41:06,040 --> 04:41:07,640
MONEY IS IN MANAGING PEER

6989
04:41:07,640 --> 04:41:10,000
REVIEW, YOU NOT ON THE RECEIVING

6990
04:41:10,000 --> 04:41:11,920
END OF THAT MONEY FOR DOING THE

6991
04:41:11,920 --> 04:41:15,320
PEER REVIEW. THERE ARE REWARDS

6992
04:41:15,320 --> 04:41:17,080
TO YOU OF DOING IT AND THERE

6993
04:41:17,080 --> 04:41:18,560
MAYBE OTHER REWARDS TO THOSE WHO

6994
04:41:18,560 --> 04:41:22,960
ENGAGE IN PEER REVIEW, I THINK

6995
04:41:22,960 --> 04:41:24,720
AS OTHERS HAVE SAID MAKING IT

6996
04:41:24,720 --> 04:41:26,400
MORE SITABLE SO WE AT THE

6997
04:41:26,400 --> 04:41:28,000
LIBRARY WE DON'T NECESSARILY

6998
04:41:28,000 --> 04:41:29,160
DRIVE CHANGES IN THE PROCESS BUT

6999
04:41:29,160 --> 04:41:30,440
WE REFLECT THEM AND WE HAVE ALSO

7000
04:41:30,440 --> 04:41:33,640
BEEN DOING SOME EXPERIMENTATION

7001
04:41:33,640 --> 04:41:37,040
OF ALLOWING FOR OPEN PEER

7002
04:41:37,040 --> 04:41:38,880
REVIEWS TO BE SUBMITTED WITH

7003
04:41:38,880 --> 04:41:39,840
ASSOCIATED JOURNAL ARTICLES SO

7004
04:41:39,840 --> 04:41:41,480
WE CAN LINK THOSE AND THOSE ARE

7005
04:41:41,480 --> 04:41:43,560
ACTUALLY GET THEIR OWN

7006
04:41:43,560 --> 04:41:44,760
IDENTIFIER. AS OTHER JOURNALS

7007
04:41:44,760 --> 04:41:48,520
ARE STARTING TO MOVE IN THAT

7008
04:41:48,520 --> 04:41:50,320
DIRECTION PROVIDE A PLATFORM

7009
04:41:50,320 --> 04:41:50,840
WHERE WE CAN REFLECT THAT

7010
04:41:50,840 --> 04:41:52,720
CHANGE.

7011
04:41:52,720 --> 04:41:54,760
>> THANK YOU. GINA.

7012
04:41:54,760 --> 04:41:58,600
>> I THINK THIS IS PERHAPS
WHERE

7013
04:41:58,600 --> 04:42:01,720
THE NIH CAN BE HELPFUL BECAUSE

7014
04:42:01,720 --> 04:42:05,520
IT DOES COST A LOT TO WRANGLE

7015
04:42:05,520 --> 04:42:07,200
REVIEWERS YET CRITICAL TO THE

7016
04:42:07,200 --> 04:42:11,120
QUALITY OF THE PUBLICATIONS. SO

7017
04:42:11,120 --> 04:42:13,240
IT MIGHT BE THE NIH -- RIGHT NOW

7018
04:42:13,240 --> 04:42:16,280
WHEN YOU WRITE AN RO1 YOU CAN

7019
04:42:16,280 --> 04:42:20,680
PUT $3,000 FOR A FIVE YEAR GRANT

7020
04:42:20,680 --> 04:42:22,600
FOR PUBLICATION, THAT IS NOT

7021
04:42:22,600 --> 04:42:24,520
ENOUGH FOR OPEN ACCESS JOURNALS

7022
04:42:24,520 --> 04:42:28,520
AT ALL.  NOT EVEN CLOSE. IF YOU

7023
04:42:28,520 --> 04:42:31,280
ARE NOT FUNDED BY HHMI OR

7024
04:42:31,280 --> 04:42:32,320
WELCOME OR SOMEBODY LIKE THAT

7025
04:42:32,320 --> 04:42:34,000
THEN YOU HAVE NO HOPE OF BEING

7026
04:42:34,000 --> 04:42:38,000
ABLE TO PAY FOR OPEN ACCESS.  SO

7027
04:42:38,000 --> 04:42:41,200
I THINK THE NIH REALLY COULD

7028
04:42:41,200 --> 04:42:42,200
STEP UP AND DO SOMETHING HERE

7029
04:42:42,200 --> 04:42:46,920
AND BE INVENTIVE AND PERHAPS

7030
04:42:46,920 --> 04:42:49,360
TODAY WE CAN THROW IDEAS ABOUT

7031
04:42:49,360 --> 04:42:50,320
HOW NIH CAN HELP IN THIS

7032
04:42:50,320 --> 04:42:52,160
PROCESS.  I AGREE WITH MARINA

7033
04:42:52,160 --> 04:42:55,680
THAT WE NEED ALL OF THESE

7034
04:42:55,680 --> 04:42:56,920
DIFFERENT JOURNALS, SPECIALTY

7035
04:42:56,920 --> 04:43:01,120
JOURNALS FROM SPECIALTY AREAS TO

7036
04:43:01,120 --> 04:43:03,080
STAY IN BUSINESS OR AT LEAST TO

7037
04:43:03,080 --> 04:43:04,400
STAY OPEN BECAUSE THAT IS A

7038
04:43:04,400 --> 04:43:09,880
PLACE WHERE PEOPLE GO TO FIND

7039
04:43:09,880 --> 04:43:12,680
THESE ARTICLES WHERE TRAINEES

7040
04:43:12,680 --> 04:43:14,680
WILL GO TO PUBLIC THEM. I THINK

7041
04:43:14,680 --> 04:43:18,800
IT WOULD BE AMAZING TO CHANGEUP

7042
04:43:18,800 --> 04:43:20,080
ALL OF ACADEMIA TO A DIFFERENT

7043
04:43:20,080 --> 04:43:21,800
PLATFORM SO YOU CAN GET PROMOTED

7044
04:43:21,800 --> 04:43:26,280
ON BASED ON THE MERE FACT OF

7045
04:43:26,280 --> 04:43:27,320
PUBLICATION NO MATTER WHERE BUT

7046
04:43:27,320 --> 04:43:30,680
RIGHT NOW THAT IS GOING TO BE A

7047
04:43:30,680 --> 04:43:34,160
MAJOR SYSTEMIC OVERHAUL AND WILL

7048
04:43:34,160 --> 04:43:36,720
TAKE BUY IN FROM MILLIONS OF

7049
04:43:36,720 --> 04:43:38,600
PEOPLE ESSENTIALLY RIGHT NOW

7050
04:43:38,600 --> 04:43:40,680
THAT ARE HAVE BENEFITED, TAKE

7051
04:43:40,680 --> 04:43:42,440
BUY IN FROM PEOPLE WHO BENEFIT

7052
04:43:42,440 --> 04:43:44,000
FROM THE CURRENT SYSTEM. THAT

7053
04:43:44,000 --> 04:43:45,680
ARE AT THE TOP OF THEIR GAME

7054
04:43:45,680 --> 04:43:46,560
BECAUSE THEY ARE ABLE TO PLAY

7055
04:43:46,560 --> 04:43:47,640
THAT GAME WITH THE CURRENT

7056
04:43:47,640 --> 04:43:49,360
SYSTEM. SO THEY ARE THE LEAST

7057
04:43:49,360 --> 04:43:51,400
LIKELY TO TRY TO BUY INTO A BIG

7058
04:43:51,400 --> 04:43:55,280
MAJOR CHANGE LIKE THIS. THESE

7059
04:43:55,280 --> 04:43:56,920
ARE A FEW OF THE PROBLEMS THAT I

7060
04:43:56,920 --> 04:43:59,120
HOPE THAT WE CAN ADDRESS TODAY,

7061
04:43:59,120 --> 04:44:04,880
THEY ARE BIG ONES THOUGH.

7062
04:44:04,880 --> 04:44:08,000
>> ANYONE WANT TO RESPOND
TO

7063
04:44:08,000 --> 04:44:09,360
THOSE POINTS? I DO JUST WANT TO

7064
04:44:09,360 --> 04:44:11,640
NOTE FROM MY PERSPECTIVE I WILL

7065
04:44:11,640 --> 04:44:14,200
TURN TO MARINA IN THAT SECOND.

7066
04:44:14,200 --> 04:44:16,160
WE TALK A LOT ABOUT THE

7067
04:44:16,160 --> 04:44:17,400
IMPORTANCE OF EQUITY AND

7068
04:44:17,400 --> 04:44:18,880
INCLUSION IN OUR RESEARCH AND

7069
04:44:18,880 --> 04:44:21,440
OUR WORK FORCE. AND IF WE ARE

7070
04:44:21,440 --> 04:44:30,200
MAKING A POINT OF INCLUDING

7071
04:44:30,200 --> 04:44:32,160
EVERYONE IS INCLUDED IN RESEARCH

7072
04:44:32,160 --> 04:44:32,920
EFFORTS WE HAVE TO MAKE SURE

7073
04:44:32,920 --> 04:44:34,840
PATH TO PUBLICATION AND NOT CREE

7074
04:44:34,840 --> 04:44:35,840
CRATING HAVEs AND HAVE NOTES

7075
04:44:35,840 --> 04:44:37,840
AND HOW TO DO THAT TRICKY.

7076
04:44:37,840 --> 04:44:38,360
MARINA.

7077
04:44:38,360 --> 04:44:40,160
>> NO, I WAS ACTUALLY JUST

7078
04:44:40,160 --> 04:44:42,560
ENDORSING WHAT GINA SAID. I

7079
04:44:42,560 --> 04:44:44,880
AGREE WITH THE IDEA THAT IN FACT

7080
04:44:44,880 --> 04:44:47,200
WE NEED TO MAKE SURE THAT AS WE

7081
04:44:47,200 --> 04:44:48,720
THINK ABOUT THE BIGGEST PROBLEMS

7082
04:44:48,720 --> 04:44:52,040
WE ARE NOT CREATING NEW PROBLEMS

7083
04:44:52,040 --> 04:44:54,760
ACROSS THE SYSTEM.

7084
04:44:54,760 --> 04:44:58,080
>> IF I CAN CHIME IN, I
THINK

7085
04:44:58,080 --> 04:44:59,880
IDEAS ABOUT HOW NIH CAN HELP

7086
04:44:59,880 --> 04:45:01,480
MOVE THE PROCESS ALONG ARE

7087
04:45:01,480 --> 04:45:04,080
ALWAYS WELCOME. I WOULD LIKE TO

7088
04:45:04,080 --> 04:45:06,120
THINK NIH HAD A FAIRLY

7089
04:45:06,120 --> 04:45:07,360
SIGNIFICANT ROLE GETTING US

7090
04:45:07,360 --> 04:45:11,640
WHERE WE ARE TODAY. THAT 2008

7091
04:45:11,640 --> 04:45:16,680
PUBLIC ACCESS POLICY WAS NEW.

7092
04:45:16,680 --> 04:45:23,080
AND AND NOT IMPLEMENTED WITHOUT

7093
04:45:23,080 --> 04:45:23,760
SIMILAR CONCERNS THAT THIS WOULD

7094
04:45:23,760 --> 04:45:25,120
UNDERMINE CURRENT MODEL OF

7095
04:45:25,120 --> 04:45:26,600
PUBLISHING AND DISENFRANCHISE. 

7096
04:45:26,600 --> 04:45:28,120
I THINK WE EVEN HEARD NOBODY

7097
04:45:28,120 --> 04:45:30,440
OTHER THAN SCIENTISTS READ THE

7098
04:45:30,440 --> 04:45:31,640
LITERATURE OR NEED ACCESS TO IT.

7099
04:45:31,640 --> 04:45:33,520
WE HAVE HAD A LOT OF EVIDENCE

7100
04:45:33,520 --> 04:45:35,440
OVER THE LAST 14 YEARS. THAT

7101
04:45:35,440 --> 04:45:36,880
PUBLISHING HAS SURVIVED SOME

7102
04:45:36,880 --> 04:45:38,840
CHANGES AND WE HAVE A LOT OF

7103
04:45:38,840 --> 04:45:41,720
PEOPLE WHO USE -- THAT THE

7104
04:45:41,720 --> 04:45:42,640
LITERATURE WITHIN THE SCIENTIFIC

7105
04:45:42,640 --> 04:45:44,480
COMMUNITY AND BEYOND. THINKING

7106
04:45:44,480 --> 04:45:49,600
THROUGH HOW CAN WE GET TO THE

7107
04:45:49,600 --> 04:45:51,320
OBJECTIVE WE WANT. GREATER

7108
04:45:51,320 --> 04:45:52,560
ACCESSIBILITY TO THINGS IN WAYS

7109
04:45:52,560 --> 04:45:55,560
THAT ARE SUSTAINABLE AND

7110
04:45:55,560 --> 04:45:56,680
SUPPORTABLE. WELCOME YOUR

7111
04:45:56,680 --> 04:45:57,680
THOUGHTS HAVING TO TRY TO MOVE

7112
04:45:57,680 --> 04:45:58,920
THAT ALONG. 

7113
04:45:58,920 --> 04:46:02,040
>> I THINK A NUMBER OF
COUNCIL

7114
04:46:02,040 --> 04:46:03,320
MEMBERS HAVE TO LEAVE AND WE ARE

7115
04:46:03,320 --> 04:46:07,120
IN DANGER OF LOSING OUR QUORUM

7116
04:46:07,120 --> 04:46:08,840
SO LAST QUESTION FROM AARON. I'M

7117
04:46:08,840 --> 04:46:09,720
FRUSTRATED BECAUSE I WOULD LOVE

7118
04:46:09,720 --> 04:46:12,480
TO HAVE ANOTHER HOUR FOR THIS

7119
04:46:12,480 --> 04:46:15,120
DISCUSSION. IT IS A RICH

7120
04:46:15,120 --> 04:46:17,920
DISCUSSION. ALL TALKS WERE

7121
04:46:17,920 --> 04:46:18,880
TERRIFIC. AARON.

7122
04:46:18,880 --> 04:46:21,120
>> MY QUESTION IS FOR DR.
STERN,

7123
04:46:21,120 --> 04:46:22,960
SEEMED LIKE IN THE SECOND POINT

7124
04:46:22,960 --> 04:46:25,400
YOU BROUGHT UP THE NEXT STEPS

7125
04:46:25,400 --> 04:46:29,240
GOING TO PUBLISHING FIRST THEN

7126
04:46:29,240 --> 04:46:31,880
PEER REVIEW SECOND, THAT LOGICAL

7127
04:46:31,880 --> 04:46:33,320
NEXT STEP OF THAT IS TO

7128
04:46:33,320 --> 04:46:38,560
ELIMINATE JOURNALS AND HAVE

7129
04:46:38,560 --> 04:46:40,240
PREPRINTS WITH PEOPLE COMMENTING

7130
04:46:40,240 --> 04:46:43,280
WHICH IS INTERESTING.  BUT THEN

7131
04:46:43,280 --> 04:46:44,320
YOU SAID IN A COMMENT THAT YOU

7132
04:46:44,320 --> 04:46:45,880
CAN'T JUST HAVE ANYONE IN THE

7133
04:46:45,880 --> 04:46:49,160
WORLD COMMENTING ON THESE

7134
04:46:49,160 --> 04:46:50,080
PREPRINTS YOU HAVE TO ORGANIZE

7135
04:46:50,080 --> 04:46:53,240
IN SOME WAY. I WONDER IF THAT IS

7136
04:46:53,240 --> 04:46:54,520
TRUE, MAYBE IF YOU COULD HAVE

7137
04:46:54,520 --> 04:46:56,360
ANYONE COMMENTING BUT PEOPLE

7138
04:46:56,360 --> 04:46:57,640
HAVE THEIR CREDIBILITY ASSESS

7139
04:46:57,640 --> 04:47:00,400
BASED ON HOW WELL THEY COMMENT. 

7140
04:47:00,400 --> 04:47:03,320
>> IF THAT WORKS. I WOULD

7141
04:47:03,320 --> 04:47:06,440
CERTAINLY ADD THAT I AGREE WE

7142
04:47:06,440 --> 04:47:08,200
SHOULD FIND WAYS PEOPLE CAN

7143
04:47:08,200 --> 04:47:11,080
CHIME IN ON ARTICLES. THAT IS

7144
04:47:11,080 --> 04:47:12,600
WHAT THE INTERNET ALLOWS, IT

7145
04:47:12,600 --> 04:47:13,560
CONNECTS EVERYBODY SO PEOPLE

7146
04:47:13,560 --> 04:47:14,800
THAT HAVE SOMETHING TO SAY

7147
04:47:14,800 --> 04:47:17,840
SHOULD BE ABLE TO SA SAY. ALL IM

7148
04:47:17,840 --> 04:47:19,320
SAYING IS DON'T SWITCH FROM

7149
04:47:19,320 --> 04:47:19,920
CURRENT SYSTEM RIGHT TO THAT

7150
04:47:19,920 --> 04:47:24,520
SYSTEM. IF JOURNALS CAN HAVE AN

7151
04:47:24,520 --> 04:47:25,360
IMPORTANT PLACE IMPORTANT ROLE

7152
04:47:25,360 --> 04:47:28,160
TO PLAY AS PEER ARE VIEW,

7153
04:47:28,160 --> 04:47:33,080
ORGANIZERSSS. CURATION SERVICES,

7154
04:47:33,080 --> 04:47:35,200
NOT AS PUBLISHERS BECAUSE IT IS

7155
04:47:35,200 --> 04:47:37,800
LIKE BIOARCHIVE OR PUBMED

7156
04:47:37,800 --> 04:47:40,040
CENTRAL, WE KNOW -- THE

7157
04:47:40,040 --> 04:47:41,400
JOURNALS, I THINK EDITORS WOULD

7158
04:47:41,400 --> 04:47:43,640
AGREE THAT THE MOST IMPORTANT

7159
04:47:43,640 --> 04:47:45,720
ROLE THEY PLAY IN APPRAISING

7160
04:47:45,720 --> 04:47:47,880
REVIEWING CONTENT SO LET'S USE

7161
04:47:47,880 --> 04:47:49,880
THE JOURNALS FOR NOW FOR THAT

7162
04:47:49,880 --> 04:47:53,320
IMPORTANT ROLE THEY PLAY. SO

7163
04:47:53,320 --> 04:47:55,320
THERE DOESN'T RULE OUT

7164
04:47:55,320 --> 04:47:56,840
COMMENTING ON THE SIDE BUT IT

7165
04:47:56,840 --> 04:47:57,720
DOESN'T MEAN NECESSARILY THAT

7166
04:47:57,720 --> 04:48:00,160
JOURNALS HAVE TO DISAPPEAR.  

7167
04:48:00,160 --> 04:48:01,360
THEY CAN PLAY -- THEY JUST

7168
04:48:01,360 --> 04:48:02,720
WOULDN'T BE PUBLISHERSK THEY

7169
04:48:02,720 --> 04:48:05,040
WOULD BE PEER REVIEW SERVICE AND

7170
04:48:05,040 --> 04:48:06,000
CURATION SERVICES.

7171
04:48:06,000 --> 04:48:08,160
>> I AM GOING TO ADJOURN
THIS

7172
04:48:08,160 --> 04:48:12,960
MEETINGING. I WANT TO THANK ALL

7173
04:48:12,960 --> 04:48:14,480
FOUR OF THE TALKS. THEY WERE

7174
04:48:14,480 --> 04:48:15,640
ABSOLUTELY GREAT AND I LEARNED

7175
04:48:15,640 --> 04:48:17,240
MUCH MORE THAN EXPECTED TO

7176
04:48:17,240 --> 04:48:19,760
LEARN. SO THANKS A LOT.  WE WILL

7177
04:48:19,760 --> 04:48:21,080
CONTINUE THIS DISCUSSION IN

7178
04:48:21,080 --> 04:48:31,680
ANOTHER FORUM. WE ARE ADJOURNED