1 00:00:06,442 --> 00:00:09,211 >> WALTER: GOOD MORNING, I'M THE 2 00:00:09,211 --> 00:00:10,579 DIRECTOR AND I WANT TO WELCOME 3 00:00:10,579 --> 00:00:12,381 PEOPLE TO THE OPEN SESSION OF 4 00:00:12,381 --> 00:00:15,884 OUR 226TH MEETING. THIS IS LIVE 5 00:00:15,884 --> 00:00:17,419 VIDEO CAST. AND WE HAVE A 6 00:00:17,419 --> 00:00:20,322 PACKED AGENDA, A NUMBER OF ITEMS 7 00:00:20,322 --> 00:00:22,157 TO GET TO AND AS YOU ALL MAY 8 00:00:22,157 --> 00:00:32,401 KNOW WE'RE SO 9 00:00:35,070 --> 00:00:37,840 >> WALTER: GOOD MORNING, I'M THE 10 00:00:37,840 --> 00:00:39,208 DIRECTOR AND I WANT TO WELCOME 11 00:00:39,208 --> 00:00:41,009 PEOPLE TO THE OPEN SESSION OF 12 00:00:41,009 --> 00:00:44,513 OUR 226TH MEETING. THIS IS LIVE 13 00:00:44,513 --> 00:00:46,048 VIDEO CAST. AND WE HAVE A 14 00:00:46,048 --> 00:00:48,951 PACKED AGENDA, A NUMBER OF ITEMS 15 00:00:48,951 --> 00:00:50,786 TO GET TO AND AS YOU ALL MAY 16 00:00:50,786 --> 00:00:54,690 KNOW WE'RE SO LUCKY TO HAVE THE 17 00:00:54,690 --> 00:00:58,026 NIH DIRECTOR TALKING TO US AT 18 00:00:58,026 --> 00:01:02,264 AROUND 10:30. SO I WANT TO 19 00:01:02,264 --> 00:01:05,901 JUST, AND IN THE BEGINNING, TALK 20 00:01:05,901 --> 00:01:08,637 ABOUT SOME OF THE NEW AD HOC 21 00:01:08,637 --> 00:01:09,938 MEMBERS THAT WE HAVE ON THE 22 00:01:09,938 --> 00:01:12,207 COUNCIL AWAITING APPROVAL FOR 23 00:01:12,207 --> 00:01:14,409 OUR SLATES FROM HHS. WE 24 00:01:14,409 --> 00:01:17,079 ACTUALLY HAVE THREE YEARS OF 25 00:01:17,079 --> 00:01:20,082 SLATES THAT DID NOT GET APPROVED 26 00:01:20,082 --> 00:01:21,183 BY THE LAST ADMINISTRATION SO A 27 00:01:21,183 --> 00:01:24,453 NUMBER OF PEOPLE ARE IN THIS 28 00:01:24,453 --> 00:01:34,763 POSITION BUT WE APPRECIATE ALL 29 00:01:34,763 --> 00:01:41,136 THEIR INPUT. FIRST IS GERALDINE 30 00:01:41,136 --> 00:01:42,771 SUNSHINE. I CAN'T SEE EVERYBODY 31 00:01:42,771 --> 00:01:48,177 BUT MISS SUN SHINE IS PRESIDENT 32 00:01:48,177 --> 00:01:51,680 OF THE ASSOCIATION AND WORKS FOR 33 00:01:51,680 --> 00:01:54,483 MASS GENERAL. SHE HOUSES A 34 00:01:54,483 --> 00:01:57,319 JOINT MISSION TO FIND A CURE FOR 35 00:01:57,319 --> 00:02:01,490 LOW BAY GO SYNDROME WHILE 36 00:02:01,490 --> 00:02:02,257 PROVIDING COMPREHENSIVE SUPPORT 37 00:02:02,257 --> 00:02:03,392 FOR THEIR PATIENTS AND FAMILIES 38 00:02:03,392 --> 00:02:05,427 AND ALSO THE PRESIDENT AND THE 39 00:02:05,427 --> 00:02:08,063 CEO OF THE ACADEMY IN THE 40 00:02:08,063 --> 00:02:09,565 PHILIPPINES AN EDUCATIONAL 41 00:02:09,565 --> 00:02:10,766 PLATFORM THAT PROVIDES LEARNING 42 00:02:10,766 --> 00:02:13,635 EXPERIENCES FOR GRADES K-12 43 00:02:13,635 --> 00:02:16,705 HIGHER EDUCATION AND LIFELONG 44 00:02:16,705 --> 00:02:22,778 LEARNERS. NEXT IS DR. LINDA 45 00:02:22,778 --> 00:02:25,180 DEBAR. DR. DEBAR HAS BEEN A 46 00:02:25,180 --> 00:02:28,450 LONG-TERM GRANTEE AND DOES 47 00:02:28,450 --> 00:02:31,620 TREMENDOUS WORK IN THE HEAL 48 00:02:31,620 --> 00:02:33,989 INITIATIVE. SHE WORKS IN THE 49 00:02:33,989 --> 00:02:34,590 NORTHWEST CENTER FOR HEALTH 50 00:02:34,590 --> 00:02:36,525 RESEARCH AND AN AFFILIATE 51 00:02:36,525 --> 00:02:38,560 PROFESSOR IN THE DEPARTMENT OF 52 00:02:38,560 --> 00:02:39,361 PSYCHIATRY AND BEHAVIORAL 53 00:02:39,361 --> 00:02:41,630 SCIENCE AT THE UNIVERSITY OF 54 00:02:41,630 --> 00:02:44,833 WASHINGTON MEDICAL SCHOOL. THE 55 00:02:44,833 --> 00:02:45,767 CLINICAL PSYCHOLOGIST, 56 00:02:45,767 --> 00:02:47,236 BEHAVIORAL HEALTH RESEARCHER WHO 57 00:02:47,236 --> 00:02:50,172 WORK TO ADDRESS HEALTH ISSUES 58 00:02:50,172 --> 00:02:51,974 AND HAS PHYSICAL AND 59 00:02:51,974 --> 00:02:53,242 PSYCHOLOGICAL CORES AND SYMPTOMS 60 00:02:53,242 --> 00:02:54,776 AND CONCENTRATED IN HELPING 61 00:02:54,776 --> 00:02:56,745 THROUGH HER RESEARCH, PEOPLE 62 00:02:56,745 --> 00:02:58,714 WITH CHRONIC PAIN AND OPIOID 63 00:02:58,714 --> 00:03:02,417 USE. PARTICULARLY THOSE WITH 64 00:03:02,417 --> 00:03:05,420 CO-OCCURRING CONDITIONS. AND SO 65 00:03:05,420 --> 00:03:08,624 HAPPY TO HAVE LYNN ON. AND NOW 66 00:03:08,624 --> 00:03:12,127 I'M GOING TO TURN THE MEETING 67 00:03:12,127 --> 00:03:14,763 OVER TO DR. ANN POE DUR RI WHO 68 00:03:14,763 --> 00:03:17,599 IS OUR DEPUTY DIRECTOR. 69 00:03:17,599 --> 00:03:23,238 I THINK WANTED TO GIVE ANN AND 70 00:03:23,238 --> 00:03:26,675 ANDY MEREDITH A CHANCE TO TALK 71 00:03:26,675 --> 00:03:29,111 ABOUT THEIR VISION FOR NINDS AS 72 00:03:29,111 --> 00:03:30,112 COMING IN FROM THE OUTSIDE AND 73 00:03:30,112 --> 00:03:34,616 SO ANN, THE DEPUTY DIRECTOR? 74 00:03:34,616 --> 00:03:36,685 >> ANN: MORNING, THANK YOU, 75 00:03:36,685 --> 00:03:39,721 WALTER AND THANK YOU TO AMY 76 00:03:39,721 --> 00:03:41,123 ADAMS AND OUR WONDERFUL NINDS 77 00:03:41,123 --> 00:03:43,959 LEADERSHIP TEAM FOR WELCOMING ME 78 00:03:43,959 --> 00:03:46,762 IN OCTOBER OF 2024. AS YOU HEAR 79 00:03:46,762 --> 00:03:48,130 IT'S BEEN A YEAR OF A LOT OF 80 00:03:48,130 --> 00:03:50,666 CHANGE AND SINCE FOR MYSELF AND 81 00:03:50,666 --> 00:03:52,234 DR. MEREDITH EVERYTHING'S BEEN 82 00:03:52,234 --> 00:03:54,403 NEW, IT'S BEEN A LOT OF CHANGE 83 00:03:54,403 --> 00:03:55,938 BUT IT'S BEEN WONDERFUL TO BE 84 00:03:55,938 --> 00:03:57,940 EMBRACED BY THIS INCREDIBLE 85 00:03:57,940 --> 00:03:58,974 TEAM. I WANT TO THANK ALL OF 86 00:03:58,974 --> 00:04:00,375 YOU FOR BEING HERE AND SERVING 87 00:04:00,375 --> 00:04:01,343 SCIENCE HERE TOGETHER WITH US. 88 00:04:01,343 --> 00:04:03,679 I KNOW MANY OF YOU FROM MY 89 00:04:03,679 --> 00:04:05,814 TRAINING ACTUALLY. I'M FROM 90 00:04:05,814 --> 00:04:06,448 COLLABORATION SECTIONS BUT NOT 91 00:04:06,448 --> 00:04:08,550 ALL OF YOU SO I THOUGHT I WOULD 92 00:04:08,550 --> 00:04:10,419 GIVE YOU A QUICK SNAPSHOT OF 93 00:04:10,419 --> 00:04:12,087 WHAT I WAS DOING BEFORE MY OWN 94 00:04:12,087 --> 00:04:13,322 RESEARCH AND CLINICAL WORK 95 00:04:13,322 --> 00:04:15,223 FOCUSED ON THE GENETICS OF 96 00:04:15,223 --> 00:04:17,225 EPILEPSY FROM A HUMAN GENETICS 97 00:04:17,225 --> 00:04:19,828 PERSPECTIVE AND ALSO ANIMAL 98 00:04:19,828 --> 00:04:21,530 MODELING AND ZEBRAFISH PRIMARILY 99 00:04:21,530 --> 00:04:23,665 AND THAT HAS EXTENDED INTO AREA 100 00:04:23,665 --> 00:04:26,501 OF TRANSLATION AND ALSO INTO 101 00:04:26,501 --> 00:04:28,103 AREAS OF ACCESS TO RESEARCH FOR 102 00:04:28,103 --> 00:04:30,973 MANY POPULATIONS. THIS WAS IN 103 00:04:30,973 --> 00:04:32,841 CONCERT WITH A LOT OF 104 00:04:32,841 --> 00:04:34,710 INTERACTIONS I'VE HAD OVER THE 105 00:04:34,710 --> 00:04:36,511 YEARS WITH THE NINDS BOTH FROM 106 00:04:36,511 --> 00:04:38,647 STUDY SECTIONS AND SO ON BUT 107 00:04:38,647 --> 00:04:40,716 ALSO REALLY MEANINGFUL 108 00:04:40,716 --> 00:04:42,250 PARTNERSHIPS BETWEEN THE NINDS 109 00:04:42,250 --> 00:04:43,151 AND PROFESSIONAL SOCIETIES AND A 110 00:04:43,151 --> 00:04:45,153 LOT OF TRAINING GRANT 111 00:04:45,153 --> 00:04:46,655 OPPORTUNITIES WHERE ONCE A 112 00:04:46,655 --> 00:04:48,256 RECIPIENT I HAVE NOW HAD THE 113 00:04:48,256 --> 00:04:50,726 OPPORTUNITY TO ENGAGE MORE IN 114 00:04:50,726 --> 00:04:51,626 THOSE ACTIVITIES SOI I HAVE BEE 115 00:04:51,626 --> 00:04:52,861 HERE JUST FOR A FEW MONTHS AND 116 00:04:52,861 --> 00:04:54,363 I'VE BEEN ABLE TO REALLY HAVE 117 00:04:54,363 --> 00:04:55,797 THE PRIVILEGE TO WORK WITH THE 118 00:04:55,797 --> 00:04:58,734 NINDS TEAM IN A LOT OF AREAS 119 00:04:58,734 --> 00:05:01,503 RELATED TO CHILD HEALTH AND 120 00:05:01,503 --> 00:05:02,771 GENETICS, THE UNDIAGNOSED 121 00:05:02,771 --> 00:05:04,272 DISEASE PROGRAM, SEVERAL OTHER 122 00:05:04,272 --> 00:05:08,944 NETWORKS BUT ALSO TO BROADEN MY 123 00:05:08,944 --> 00:05:11,113 LENS OUT BACK TO THE ADULT 124 00:05:11,113 --> 00:05:13,415 DISORDERS I STUDIED ONCE UPON A 125 00:05:13,415 --> 00:05:14,783 TEAM AND RELEARN AND TAKE 126 00:05:14,783 --> 00:05:16,118 ADVANTAGE OF THE PROGRESS THAT'S 127 00:05:16,118 --> 00:05:17,886 BEEN GOING ON IN THE FIELD AND 128 00:05:17,886 --> 00:05:19,888 THROUGH MANY, MANY DIFFERENT 129 00:05:19,888 --> 00:05:20,756 COLLABORATIVE INITIATIVES ACROSS 130 00:05:20,756 --> 00:05:23,025 THE NIH AND ALSO ACROSS THE 131 00:05:23,025 --> 00:05:24,626 COUNTRY IN THE RESEARCH SPHERE 132 00:05:24,626 --> 00:05:26,695 SO THAT HAS BEEN INCREDIBLE BUT 133 00:05:26,695 --> 00:05:28,063 REALLY THE MOST INCREDIBLE PART 134 00:05:28,063 --> 00:05:30,032 IS BEING HERE WITH YOU TO REALLY 135 00:05:30,032 --> 00:05:31,500 DO THE WORK THAT WE'RE ALL HERE 136 00:05:31,500 --> 00:05:32,701 TO DO WHICH IS TO MAKE RESEARCH 137 00:05:32,701 --> 00:05:35,437 HAPPEN ACROSS THE COUNTRY SO I'M 138 00:05:35,437 --> 00:05:37,072 MOST GRATEFUL TO EVERYBODY TO BE 139 00:05:37,072 --> 00:05:38,774 HERE TOGETHER. AND I ALSO WANT 140 00:05:38,774 --> 00:05:41,043 TO ACKNOWLEDGE THAT WE ARE IN 141 00:05:41,043 --> 00:05:43,311 UNCERTAIN TIMES, WE KEEP HEARING 142 00:05:43,311 --> 00:05:46,548 ABOUT HOW A LOT OF CHANGES ARE 143 00:05:46,548 --> 00:05:47,149 UNPRECEDENTED AND PEOPLE ARE 144 00:05:47,149 --> 00:05:49,151 TRYING TO FIGURE OUT HOW TO KEEP 145 00:05:49,151 --> 00:05:53,055 THE MISSION IN FOCUS AND WE NEED 146 00:05:53,055 --> 00:05:55,557 TO DO THAT MORE THAN EVER AND WE 147 00:05:55,557 --> 00:05:56,625 NEED EACH OTHER MORE THAN EVER 148 00:05:56,625 --> 00:05:58,760 AND TO SUPPORT OUR MISSION WHICH 149 00:05:58,760 --> 00:06:00,228 IS TO DO GOOD SCIENCE AND 150 00:06:00,228 --> 00:06:01,897 CULTIVATE A WORKFORCE TO KEEP AT 151 00:06:01,897 --> 00:06:03,532 IT LONG AFTER WE'RE ALL DONE 152 00:06:03,532 --> 00:06:04,466 DOING WHAT WE'RE DOING. SO 153 00:06:04,466 --> 00:06:06,134 WE'VE AGAIN, THERE'S A LOT OF 154 00:06:06,134 --> 00:06:08,770 NEGATIVES UNPRECEDENTED, UNHEARD 155 00:06:08,770 --> 00:06:10,172 OF, UNCERTAIN AND THAT SOUNDS 156 00:06:10,172 --> 00:06:11,473 VERY NEGATIVE AND FEELS NEGATIVE 157 00:06:11,473 --> 00:06:13,608 BUT I REALLY, NOT TO TRY TO 158 00:06:13,608 --> 00:06:15,544 GLOSS THINGS OVER BUT WANT TO 159 00:06:15,544 --> 00:06:17,412 FOCUS NOW ON WHAT WE ARE HERE TO 160 00:06:17,412 --> 00:06:18,814 DO TOGETHER AND THERE'S SOME 161 00:06:18,814 --> 00:06:19,781 VERY POSITIVE THINGS THAT WE 162 00:06:19,781 --> 00:06:21,783 KEEP REMIND OURSELVES ABOUT. 163 00:06:21,783 --> 00:06:22,818 NOW THE FIRST IS THAT WE NEED TO 164 00:06:22,818 --> 00:06:24,686 STAY FOCUSED PARTICULARLY AS 165 00:06:24,686 --> 00:06:27,355 WE'RE TALKING TO OUR YOUNG 166 00:06:27,355 --> 00:06:28,757 RESEARCH COMMUNITY. ON THE NEED 167 00:06:28,757 --> 00:06:30,792 FOR THE RESEARCH THAT WE'RE 168 00:06:30,792 --> 00:06:32,561 PROMOTING AND THAT WE'RE DOING. 169 00:06:32,561 --> 00:06:34,362 THE CHILDREN AND ADULTS WITH 170 00:06:34,362 --> 00:06:36,598 NEUROLOGICAL DISORDERS ARE NOT 171 00:06:36,598 --> 00:06:37,666 GOING AWAY JUST BECAUSE THINGS 172 00:06:37,666 --> 00:06:39,134 ARE CHANGE AND THE TIMES ARE 173 00:06:39,134 --> 00:06:41,336 CHANGING. THEY'RE EVERYDAY IN 174 00:06:41,336 --> 00:06:42,771 CLINIC. AND THE DOCTORS WHO SEE 175 00:06:42,771 --> 00:06:44,272 THEM, THE NURSES WHO SEE THEM, 176 00:06:44,272 --> 00:06:46,374 THE GENETIC COUNSELOR WHO IS SEE 177 00:06:46,374 --> 00:06:49,344 THEM ARE VERY MUCH AWARE OF THE 178 00:06:49,344 --> 00:06:50,712 NEED FOR RESEARCH IF THE STATUS 179 00:06:50,712 --> 00:06:53,882 QUO WAS PERFECT WE WON'T NEED 180 00:06:53,882 --> 00:06:54,449 TRANSLATIONAL RESEARCH BUT 181 00:06:54,449 --> 00:06:56,218 THERE'S A LOT OF UNMET NEED AND 182 00:06:56,218 --> 00:06:57,586 PROMISE FROM THE WORK THAT'S 183 00:06:57,586 --> 00:06:59,754 GOING ON SO WE NEED TO STAY 184 00:06:59,754 --> 00:07:01,523 FOCUSED ON THE VERY REALLY 185 00:07:01,523 --> 00:07:02,190 APPLICABILITY AND THE URGENT 186 00:07:02,190 --> 00:07:03,558 NEED FOR OUR WORK TO CONTINUE. 187 00:07:03,558 --> 00:07:06,761 I THINK WE ALSO HAVE TO CONTINUE 188 00:07:06,761 --> 00:07:07,796 TO CULTIVATE THE SCIENCE AND 189 00:07:07,796 --> 00:07:09,898 RECOGNIZE IT'S A COMBINATION OF 190 00:07:09,898 --> 00:07:11,199 OUR BASIC FUNDAMENTAL 191 00:07:11,199 --> 00:07:12,567 NEUROSCIENCE, OUR CLINICAL 192 00:07:12,567 --> 00:07:13,668 RESEARCH AND THE TRANSLATIONAL 193 00:07:13,668 --> 00:07:17,205 WORK THAT GOES ON BETWEEN THEM 194 00:07:17,205 --> 00:07:18,607 THAT REALLY BRINGS ALL OF THESE 195 00:07:18,607 --> 00:07:19,808 PARTS TOGETHER THAT ACKNOWLEDGES 196 00:07:19,808 --> 00:07:22,777 THE VALUE OF ALL OF THESE 197 00:07:22,777 --> 00:07:25,580 THINGS. SOME OF THE FUNDAMENTAL 198 00:07:25,580 --> 00:07:30,051 WORK MAY HAVE THE APPLICABILITY 199 00:07:30,051 --> 00:07:32,120 IN 10-20 YEARS AND TO MERGE 200 00:07:32,120 --> 00:07:33,989 THOSE AND THINK ABOUT THOSE IN 201 00:07:33,989 --> 00:07:35,624 ONE ROOM AND UNDER ONE ROOF 202 00:07:35,624 --> 00:07:36,992 TOGETHER BRINGS PEOPLE TOGETHER, 203 00:07:36,992 --> 00:07:38,126 BRINGS RESEARCHERS TOGETHER AND 204 00:07:38,126 --> 00:07:39,427 ALLOWS THAT TRANSLATION TO 205 00:07:39,427 --> 00:07:41,363 HAPPEN FASTER. I THINK WE ALSO 206 00:07:41,363 --> 00:07:43,798 REALLY NEED TO PRESERVE A 207 00:07:43,798 --> 00:07:44,933 CULTURE OF MENTORSHIP. THAT 208 00:07:44,933 --> 00:07:46,067 COMES THROUGH AND YOU'LL HEAR 209 00:07:46,067 --> 00:07:47,435 ABOUT THAT THROUGH THE TRAINING 210 00:07:47,435 --> 00:07:48,670 MECHANISMS, THROUGH THE AWARDS 211 00:07:48,670 --> 00:07:50,238 THAT GO THROUGH TWO OF THE 212 00:07:50,238 --> 00:07:51,473 PEOPLE THAT ARE NOT ONLY WELL 213 00:07:51,473 --> 00:07:53,742 RECOGNIZED RESEARCHERS INCLUDING 214 00:07:53,742 --> 00:07:54,809 THOSE IN OUR GROUP AMONG US 215 00:07:54,809 --> 00:07:56,645 TODAY BUT THOSE WHO HAVE PUT 216 00:07:56,645 --> 00:08:02,050 MENTORSHIP AT THE FRONT OF THEIR 217 00:08:02,050 --> 00:08:03,385 CAREERS. I AM HEARING QUITE A 218 00:08:03,385 --> 00:08:04,986 LOT OF ANXIETY AND UNCERTAINTY 219 00:08:04,986 --> 00:08:06,454 FROM TRAINEES AND FROM PEOPLE 220 00:08:06,454 --> 00:08:07,656 WHO THOUGHT THEY WERE ON ONE 221 00:08:07,656 --> 00:08:11,126 PATH AND MAYBE HAVE TO RETACKLE 222 00:08:11,126 --> 00:08:13,061 A LITTLE BIT AND NOT SURE HOW 223 00:08:13,061 --> 00:08:14,262 THE INSTITUTIONS CAN BUFFER THEM 224 00:08:14,262 --> 00:08:16,298 AT THIS MOMENT. IT'S NOT EASY, 225 00:08:16,298 --> 00:08:18,767 IT'S NEVER BEEN EASY, THE PEOPLE 226 00:08:18,767 --> 00:08:20,936 HERE AS OUR ESTABLISHED 227 00:08:20,936 --> 00:08:22,337 COMMUNITY KNOW THAT IT WASN'T AN 228 00:08:22,337 --> 00:08:25,207 EASY PATH BUT A PATH WE FOSTERED 229 00:08:25,207 --> 00:08:28,243 TOGETHER AND WE NEED TO KEEP 230 00:08:28,243 --> 00:08:30,111 DOING THAT TO ENSURE OUR YOUNGER 231 00:08:30,111 --> 00:08:32,147 FOLKS CANNOT ONLY DO THE SCIENCE 232 00:08:32,147 --> 00:08:33,682 THEY WANT TO DO BUT HELP MAKE 233 00:08:33,682 --> 00:08:34,950 ADVANCES TOWARDS ENDING AND 234 00:08:34,950 --> 00:08:36,685 CURING NEUROLOGICAL DISORDERS. 235 00:08:36,685 --> 00:08:38,620 THIS IS NOT JUST SOMETHING WE 236 00:08:38,620 --> 00:08:39,354 TALK ABOUT BUT SOMETHING WE'RE 237 00:08:39,354 --> 00:08:40,855 REALLY SEEING HAPPEN. THE 238 00:08:40,855 --> 00:08:41,489 AMAZING PROGRESS THAT'S BEEN 239 00:08:41,489 --> 00:08:43,458 MADE IN A LOT OF DIFFERENT 240 00:08:43,458 --> 00:08:44,659 SPHERES. THAT HAS TO KEEP 241 00:08:44,659 --> 00:08:45,760 HAPPENING AND WE HAVE TO MAKE 242 00:08:45,760 --> 00:08:50,031 SURE WE KEEP A LIFELINE OUT BOTH 243 00:08:50,031 --> 00:08:50,665 IN TERMS OF ACTUAL FUNDING AND 244 00:08:50,665 --> 00:08:52,367 IN TERMS OF CAREER DEVELOPMENT 245 00:08:52,367 --> 00:08:54,369 AND ENCOURAGEMENT. MANY OF YOU 246 00:08:54,369 --> 00:08:56,304 IN THE ROOM ARE DEPARTMENT 247 00:08:56,304 --> 00:08:57,906 CHAIRS AND INSTITUTE DIRECTORS 248 00:08:57,906 --> 00:08:58,773 AND IT'S GOING TO BE THAT 249 00:08:58,773 --> 00:09:00,742 PARTNERSHIP WITH YOU THAT'S 250 00:09:00,742 --> 00:09:01,509 GOING TO BE MORE IMPORTANT THAN 251 00:09:01,509 --> 00:09:03,245 EVER IN THESE COMING MONTHS AND 252 00:09:03,245 --> 00:09:04,546 YEARS. THE FINAL THING I THINK 253 00:09:04,546 --> 00:09:05,313 WE CAN DO TOGETHER IN A POSITIVE 254 00:09:05,313 --> 00:09:08,116 WAY IS TO COMMUNICATE, WE'RE 255 00:09:08,116 --> 00:09:08,650 COMMUNICATING HERE TODAY 256 00:09:08,650 --> 00:09:09,684 TOGETHER BUT WHEN WE'RE 257 00:09:09,684 --> 00:09:10,785 COMMUNICATING TO OUR RESEARCH 258 00:09:10,785 --> 00:09:13,188 COMMUNITY AND OUR TRAINEES AND 259 00:09:13,188 --> 00:09:14,489 WE HAVE TO KEEP THAT DIALOGUE 260 00:09:14,489 --> 00:09:16,758 GOING. SOME OF IT IS GOING TO 261 00:09:16,758 --> 00:09:22,764 BE BETWEEN NINDS BUT IT HAS TO 262 00:09:22,764 --> 00:09:24,332 KEEP HAPPENING AND IT'S NEVER 263 00:09:24,332 --> 00:09:26,034 BEEN A MORE IMPORTANT TIME TO 264 00:09:26,034 --> 00:09:27,235 COMMUNICATE WITH EACH OTHER BUT 265 00:09:27,235 --> 00:09:29,337 AS WALTER OFTEN SAYS AND I THINK 266 00:09:29,337 --> 00:09:30,805 WE HAVE TO REMIND OURSELF OF 267 00:09:30,805 --> 00:09:31,940 THIS TOO WE HAVE TO COMMUNICATE 268 00:09:31,940 --> 00:09:33,375 WITH THE COMMUNITY. WE'RE HERE 269 00:09:33,375 --> 00:09:36,444 TO PROMOTE NEUROSCIENCE TO 270 00:09:36,444 --> 00:09:38,413 ADVANCE MEDICINE AND SCIENCE TO 271 00:09:38,413 --> 00:09:40,115 PROMOTE THE END AND 272 00:09:40,115 --> 00:09:42,417 UNDERSTANDING AND THEN END OF 273 00:09:42,417 --> 00:09:43,918 SOME NEUROLOGICAL DISORDERS SO 274 00:09:43,918 --> 00:09:46,755 MAYBE IN 50 YEARS PEOPLE WILL 275 00:09:46,755 --> 00:09:48,123 NOT BE TALKING ABOUT THE SAME 276 00:09:48,123 --> 00:09:48,857 PROBLEMS BUT NEW PROBLEMS WILL 277 00:09:48,857 --> 00:09:49,924 BE ADDRESSED BUT TO UNDERSTAND 278 00:09:49,924 --> 00:09:52,027 THE IMPACT ON THE AMERICAN 279 00:09:52,027 --> 00:09:53,962 PEOPLE WE REALLY HAVE TO GET OUT 280 00:09:53,962 --> 00:09:56,164 THERE AND TALK TO OUR PATIENTS, 281 00:09:56,164 --> 00:09:59,968 OUR COLLEAGUES, OUR NEIGHBORS, 282 00:09:59,968 --> 00:10:01,036 OUR LOCAL HIGH SCHOOL STUDENTS 283 00:10:01,036 --> 00:10:03,238 AND MIDDLE SCHOOL STUDENTS. WHO 284 00:10:03,238 --> 00:10:04,472 IT'S NOT HARD TO GET EXCITED 285 00:10:04,472 --> 00:10:06,074 ABOUT THE BRAIN. WE NEED TO GET 286 00:10:06,074 --> 00:10:07,709 OUT THERE WHEN WE'RE ON THE BUS 287 00:10:07,709 --> 00:10:10,011 OR THE METRO OR WHEREVER WE 288 00:10:10,011 --> 00:10:11,980 MIGHT BE COMMUTING AND MAKE SURE 289 00:10:11,980 --> 00:10:13,748 PEOPLE KNOW WHAT WE DO IN 290 00:10:13,748 --> 00:10:14,749 SCIENCE. PEOPLE ARE REALLY 291 00:10:14,749 --> 00:10:16,284 EXCITED TO HEAR ABOUT GENETICS 292 00:10:16,284 --> 00:10:17,752 AND THE BRAIN AND THE BRAIN 293 00:10:17,752 --> 00:10:18,787 INITIATIVE AND I READ ABOUT THAT 294 00:10:18,787 --> 00:10:20,755 IN THE NEWSPAPER AND WE GOT TO 295 00:10:20,755 --> 00:10:22,090 KEEP THAT EXCITEMENT ALIVE. THE 296 00:10:22,090 --> 00:10:24,326 WORK IS NEEDED. YOUR WORK IS 297 00:10:24,326 --> 00:10:27,462 NEEDED. AND I WILL JUST END BY 298 00:10:27,462 --> 00:10:29,297 THANKING YOU AGAIN FOR BEING 299 00:10:29,297 --> 00:10:30,765 HERE AND HOPE WE CAN STICK THIS 300 00:10:30,765 --> 00:10:33,368 OUT, THIS PERIOD OUT TOGETHER 301 00:10:33,368 --> 00:10:35,603 AND THE COUNTRY NEEDS US AND OUR 302 00:10:35,603 --> 00:10:36,438 RESEARCHERS NEED US AND 303 00:10:36,438 --> 00:10:38,740 CERTAINLY OUR PATIENTS NEED US. 304 00:10:38,740 --> 00:10:42,777 THANKS, TURN THINGS OVER TO 305 00:10:42,777 --> 00:10:43,445 ANDY. 306 00:10:43,445 --> 00:10:44,713 >> ANDREA: THANKS, ANN, I 307 00:10:44,713 --> 00:10:46,748 COULDN'T HAVE SAID IT BETTER 308 00:10:46,748 --> 00:10:52,220 MYSELF. I JOINED JUST DR. ANN 309 00:10:52,220 --> 00:10:53,888 JUST LAST NOVEMBER. THIS IS MY 310 00:10:53,888 --> 00:10:56,024 FIRST TIME IN THE DRIVER'S SEAT. 311 00:10:56,024 --> 00:10:57,826 WALTER ASKED TO SPEAK ABOUT OUR 312 00:10:57,826 --> 00:11:01,062 BACKGROUND. LIKE ANN I CAME TO 313 00:11:01,062 --> 00:11:05,600 THINK BIGGER AFTER STUDYING ION 314 00:11:05,600 --> 00:11:06,768 CHANNELOPATHY EXCITABILITY. IN 315 00:11:06,768 --> 00:11:09,371 MANY RESPECTS MY SHORT TIME HERE 316 00:11:09,371 --> 00:11:12,207 HAS BEEN CHARACTERIZED BY BIG 317 00:11:12,207 --> 00:11:14,275 CHANGES IN EXTRAMURAL POLICY AND 318 00:11:14,275 --> 00:11:15,543 PROCESS AND WALTER'S GOING TO 319 00:11:15,543 --> 00:11:17,145 DISCUSS SOME OF THOSE SPECIFICS 320 00:11:17,145 --> 00:11:18,646 LATER IN HIS DIRECTOR'S REPORT. 321 00:11:18,646 --> 00:11:20,448 BUT I'LL SAY THAT I FEEL 322 00:11:20,448 --> 00:11:21,383 CHALLENGED TO APPROACH OUR 323 00:11:21,383 --> 00:11:26,354 MISSION BEYOND HOW WE'VE 324 00:11:26,354 --> 00:11:27,389 TRADITIONALLY DONE IT. THINKING 325 00:11:27,389 --> 00:11:29,824 ABOUT NEW PATHS, NEW 326 00:11:29,824 --> 00:11:31,126 POSSIBILITIES FOR HOW WE CAN 327 00:11:31,126 --> 00:11:32,794 ACCOMPLISH THE EXTRAMURAL SIDE 328 00:11:32,794 --> 00:11:33,928 OF THAT MISSION SO LET ME KICK 329 00:11:33,928 --> 00:11:35,864 OFF THE OPEN SESSION WITH A 330 00:11:35,864 --> 00:11:37,665 SHORT DEA DIRECTOR'S REPORT. 331 00:11:37,665 --> 00:11:39,567 AND I WANT TO START WITH AN 332 00:11:39,567 --> 00:11:41,136 OVERVIEW OF THE WIDE RANGE OF 333 00:11:41,136 --> 00:11:44,506 SPECIAL PROGRAMS THAT WE FUND AT 334 00:11:44,506 --> 00:11:45,540 NINDS AND I WANT TO DRAW YOUR 335 00:11:45,540 --> 00:11:47,409 ATTENTION TO THE FACT THAT 336 00:11:47,409 --> 00:11:49,277 TWO-THIRDS OF THESE USE 337 00:11:49,277 --> 00:11:51,846 SPECIALIZED FUNDING OPPORTUNITY 338 00:11:51,846 --> 00:11:52,447 ANNOUNCEMENTS. RATHER THAN 339 00:11:52,447 --> 00:11:56,885 GENERAL PARENT ANNOUNCEMENTS. 340 00:11:56,885 --> 00:12:00,054 SLIDE IS UP. OUR FUNDING 341 00:12:00,054 --> 00:12:01,055 OPPORTUNITIES ARE DESIGNED WITH 342 00:12:01,055 --> 00:12:02,757 SPECIFIC ENTRY REVIEW CRITERIA 343 00:12:02,757 --> 00:12:03,792 THAT ARE TAILORED TO OUR 344 00:12:03,792 --> 00:12:05,827 SCIENTIFIC AND REGULATORY 345 00:12:05,827 --> 00:12:08,329 OUTCOMES. AND WE HAVE 54 NINDS 346 00:12:08,329 --> 00:12:10,198 ISSUED FUNDING OPPORTUNITIES 347 00:12:10,198 --> 00:12:12,000 ACTIVE RIGHT NOW. WHICH COVER 348 00:12:12,000 --> 00:12:13,535 GAPS IN THOSE PARENT 349 00:12:13,535 --> 00:12:14,769 ANNOUNCEMENTS. SO WE HAVE 350 00:12:14,769 --> 00:12:18,106 PROGRAMS LIKE THE BLUEPRINT FOR 351 00:12:18,106 --> 00:12:20,809 NEUROSCIENCE, THEY HAVE DISTINCT 352 00:12:20,809 --> 00:12:22,444 NINDS ISSUED OPPORTUNITIES, FOR 353 00:12:22,444 --> 00:12:24,546 EXAMPLE, NEUROTHERAPEUTICS, THE 354 00:12:24,546 --> 00:12:26,314 MED TECH PROGRAM AND OUR 355 00:12:26,314 --> 00:12:29,918 TRAINING PROGRAMS. MANY OF OUR 356 00:12:29,918 --> 00:12:31,619 TRANSLATIONAL AND CLINICAL 357 00:12:31,619 --> 00:12:32,654 RESEARCH PROGRAMS REQUIRE 358 00:12:32,654 --> 00:12:33,655 SPECIALIZED FUNDING 359 00:12:33,655 --> 00:12:34,923 ANNOUNCEMENTS. CAN YOU CLICK ON 360 00:12:34,923 --> 00:12:36,991 THAT SLIDE? I THINK THERE'S 361 00:12:36,991 --> 00:12:41,229 SOME STUFF MISSING FROM THE TOP. 362 00:12:41,229 --> 00:12:43,998 THANK YOU. CLICK AGAIN. THERE 363 00:12:43,998 --> 00:12:45,934 WE GO. MANY OF OUR 364 00:12:45,934 --> 00:12:48,436 TRANSLATIONAL AND CLINICAL 365 00:12:48,436 --> 00:12:49,904 RESEARCH PROGRAMS REQUIRE THESE 366 00:12:49,904 --> 00:12:51,439 SPECIALIZED FUNDING 367 00:12:51,439 --> 00:12:52,173 ANNOUNCEMENTS BECAUSE THEY 368 00:12:52,173 --> 00:12:54,075 INVOLVE LARGE MULTICENTER 369 00:12:54,075 --> 00:12:56,744 STUDIES WITH COMPLEX 370 00:12:56,744 --> 00:12:57,345 INFRASTRUCTURE INCLUDING THE 371 00:12:57,345 --> 00:12:58,713 ABILITY TO INTEGRATE A NEW 372 00:12:58,713 --> 00:13:02,050 COMPONENT WITH EXISTING TRIALS. 373 00:13:02,050 --> 00:13:05,620 SUCH AS THE UG 3 UH 3 STROKE NET 374 00:13:05,620 --> 00:13:08,723 CLINICAL TRIALS AND BIOMARKER 375 00:13:08,723 --> 00:13:09,991 STUDIES WE ALSO USE MILESTONE 376 00:13:09,991 --> 00:13:11,893 DRIVEN FUNDING MECHANISMS AND 377 00:13:11,893 --> 00:13:13,228 OUR SPECIALIZED OPPORTUNITIES 378 00:13:13,228 --> 00:13:14,762 THAT ALLOW US TO ADVANCE THE 379 00:13:14,762 --> 00:13:16,698 RESEARCH BY A SEQUENTIAL STEPS 380 00:13:16,698 --> 00:13:19,701 IN DEPENDENT AIMS THIS MITIGATES 381 00:13:19,701 --> 00:13:21,469 OUR RISK ESPECIALLY FOR HIGH 382 00:13:21,469 --> 00:13:24,172 RISK EARLY STAGE PROJECTS. WE 383 00:13:24,172 --> 00:13:26,274 USE THESE SPECIALIZED FUNDING 384 00:13:26,274 --> 00:13:27,475 OPPORTUNITIES TO ACHIEVE THE 385 00:13:27,475 --> 00:13:29,444 UNIQUE REQUIREMENTS WITHIN OUR 386 00:13:29,444 --> 00:13:30,745 CONGRESSIONALLY MANDATED 387 00:13:30,745 --> 00:13:32,714 PROGRAMS INCLUDING THE BRAIN 388 00:13:32,714 --> 00:13:33,414 INITIATIVE WHICH YOU'LL HEAR 389 00:13:33,414 --> 00:13:36,184 ABOUT FROM JOHN LATER IN THE 390 00:13:36,184 --> 00:13:38,586 AGENDA. THE HEAL INITIATIVE 391 00:13:38,586 --> 00:13:42,490 WHICH IS CO-LED BY THE NINDS. 392 00:13:42,490 --> 00:13:44,759 AND OUR TARGETED APPROPRIATIONS 393 00:13:44,759 --> 00:13:46,761 FOR PAIN RESEARCH WHICH REQUIRE 394 00:13:46,761 --> 00:13:49,731 THOSE SPECIALIZED FUNDING 395 00:13:49,731 --> 00:13:50,598 OPPORTUNITIES TO TARGET SPECIFIC 396 00:13:50,598 --> 00:13:52,133 PRIORITY AREAS SUCH AS THE 397 00:13:52,133 --> 00:13:55,069 DEVELOPMENT OF NON OPIOID PAIN 398 00:13:55,069 --> 00:13:55,770 THERAPE 399 00:13:55,770 --> 00:13:56,104 THERAPEUTICS. 400 00:13:56,104 --> 00:13:57,839 THERE'S THE ALS EXPANDED ACCESS 401 00:13:57,839 --> 00:13:59,541 PROGRAM WHICH PROVIDES 402 00:13:59,541 --> 00:14:01,042 INVESTIGATIONAL TREATMENT TO 403 00:14:01,042 --> 00:14:02,477 PATIENTS THAT ARE NOT ELIGIBLE 404 00:14:02,477 --> 00:14:04,345 FOR CLINICAL TRIALS WITH 405 00:14:04,345 --> 00:14:06,748 ACCELERATED REVIEW TIMEFRAMES. 406 00:14:06,748 --> 00:14:08,249 THE ALZHEIMER'S DISEASE AND 407 00:14:08,249 --> 00:14:10,585 ALZHEIMER'S RELATED DEMENTIAS 408 00:14:10,585 --> 00:14:13,454 PROGRAM WHICH ARE CO-LED BY NIA 409 00:14:13,454 --> 00:14:15,557 AND US HAVE 35 ALZHEIMER'S 410 00:14:15,557 --> 00:14:21,162 DISEASE RESEARCH CENTERS THAT 411 00:14:21,162 --> 00:14:22,063 SPAN BASIC TRANSLATIONAL 412 00:14:22,063 --> 00:14:23,598 RESEARCH AND THE COORDINATION IS 413 00:14:23,598 --> 00:14:25,667 ACHIEVED THROUGH RESPECTIVE 414 00:14:25,667 --> 00:14:26,134 SPECIALIZED FUNDING 415 00:14:26,134 --> 00:14:28,503 OPPORTUNITIES AT EACH INSTITUTE. 416 00:14:28,503 --> 00:14:30,405 AND THEN WE HAVE MANY 417 00:14:30,405 --> 00:14:31,272 PARTNERSHIPS THAT INVOLVE 418 00:14:31,272 --> 00:14:33,174 DIVERSE FUNDING MECHANISMS, 419 00:14:33,174 --> 00:14:35,944 GRANTS, COOPERATIVE AGREEMENTS, 420 00:14:35,944 --> 00:14:36,844 CONTRACTS, THAT CAN'T FIT UNDER 421 00:14:36,844 --> 00:14:38,546 SINGLE PARENT ANNOUNCEMENTS. 422 00:14:38,546 --> 00:14:42,050 AND USE OUR SPECIALIZED FUNDING 423 00:14:42,050 --> 00:14:45,019 OPPORTUNITIES. FOR EXAMPLE, THE 424 00:14:45,019 --> 00:14:45,520 ACCELERATING MEDICINES 425 00:14:45,520 --> 00:14:46,621 PARTNERSHIP WHICH BRINGS 426 00:14:46,621 --> 00:14:49,824 TOGETHER NIH, FDA, PHARMA 427 00:14:49,824 --> 00:14:52,126 INDUSTRY AND FOUNDATIONS TO 428 00:14:52,126 --> 00:14:53,027 SPEED THE IDENTIFICATION OF NEW 429 00:14:53,027 --> 00:14:56,197 DISEASE TARGETS AND TREATMENTS 430 00:14:56,197 --> 00:14:58,733 IN PARKINSON'S AND ALS. AND THE 431 00:14:58,733 --> 00:15:00,902 LAST POINT I'LL MAKE IS THAT 432 00:15:00,902 --> 00:15:02,637 SPECIALIZED FUNDING OPPORTUNITY 433 00:15:02,637 --> 00:15:04,005 ANNOUNCEMENTS CONTRIBUTE TO OUR 434 00:15:04,005 --> 00:15:05,840 OUTCOMES TRACKING. THIS HELPS 435 00:15:05,840 --> 00:15:08,142 US ASSESS THE IMPACT OF OUR 436 00:15:08,142 --> 00:15:10,745 FUNDING DECISIONS OVER TIME. 437 00:15:10,745 --> 00:15:12,780 AND TO REPORT BACK TO CONGRESS. 438 00:15:12,780 --> 00:15:14,449 I FOCUS ON THESE POINTS BECAUSE 439 00:15:14,449 --> 00:15:16,351 WE'RE IMPLEMENTING A NEW 440 00:15:16,351 --> 00:15:18,653 APPROVAL PROCESS FOR NIH FUNDING 441 00:15:18,653 --> 00:15:20,154 OPPORTUNITIES AT BOTH THE NIH 442 00:15:20,154 --> 00:15:22,390 DIRECTOR AND THE HHS LEVELS. SO 443 00:15:22,390 --> 00:15:23,992 IT'S GOING TO BE A SLOWER 444 00:15:23,992 --> 00:15:26,227 PROCESS THAN WHAT MANY ARE USED 445 00:15:26,227 --> 00:15:28,296 TO. AND YOU'LL SEE THAT WE HAVE 446 00:15:28,296 --> 00:15:29,897 ONLY ONE CONCEPT FOR COUNCIL 447 00:15:29,897 --> 00:15:31,966 APPROVAL LATER IN THIS MEETING. 448 00:15:31,966 --> 00:15:34,102 THERE'S ALSO AN NIH-WIDE EFFORT 449 00:15:34,102 --> 00:15:36,304 TO SIMPLIFY AND STREAMLINE 450 00:15:36,304 --> 00:15:39,040 FUNDING OPPORTUNITIES ACROSS THE 451 00:15:39,040 --> 00:15:41,175 BOARD. WHICH CHALLENGE US TO 452 00:15:41,175 --> 00:15:42,977 REIMAGINE HOW WE CRAFT OUR 453 00:15:42,977 --> 00:15:44,979 PROGRAMS AND PRODUCE THE 454 00:15:44,979 --> 00:15:46,948 INTENDED OUTCOMES. SO I THINK 455 00:15:46,948 --> 00:15:49,517 IT'S IMPORTANT TO NOTE AS WE 456 00:15:49,517 --> 00:15:50,118 OPERATIONALIZE THESE CHANGES 457 00:15:50,118 --> 00:15:53,454 THAT WE LOOK FORWARD TO THE 458 00:15:53,454 --> 00:15:54,455 FEEDBACK AND EXPERTISE OFFERED 459 00:15:54,455 --> 00:15:56,024 BY THESE COUNCIL MEETINGS AND 460 00:15:56,024 --> 00:15:56,991 THIS COUNCIL INTERACTION IS 461 00:15:56,991 --> 00:15:59,560 CRITICAL TO HOW WE THINK ABOUT 462 00:15:59,560 --> 00:16:01,763 OUR PRIORITIES. AND REFLECT HOW 463 00:16:01,763 --> 00:16:05,199 WE UPHOLD FAIRNESS AND RIGOR IN 464 00:16:05,199 --> 00:16:07,402 OUR EXTRAMURAL PROGRAMS. SO 465 00:16:07,402 --> 00:16:08,269 NORMALLY WE WOULD RECOGNIZE NEW 466 00:16:08,269 --> 00:16:10,772 STAFF IN THIS REPORT. WHICH WE 467 00:16:10,772 --> 00:16:13,007 ACTUALLY DON'T HAVE AT THIS 468 00:16:13,007 --> 00:16:14,242 TIME. HOWEVER, I'D LIKE TO TAKE 469 00:16:14,242 --> 00:16:15,476 A MOMENT TO ACKNOWLEDGE THE 470 00:16:15,476 --> 00:16:18,780 STAFF WHO HAVE RECENTLY DEPARTED 471 00:16:18,780 --> 00:16:26,754 FROM NINDS CAN I HAVE THAT SLOO 472 00:16:26,754 --> 00:16:31,859 SLIDE? WE HAVE A SLIDE OF THE 473 00:16:31,859 --> 00:16:33,728 MANY PEOPLE THAT HAVE LEFT NI 474 00:16:33,728 --> 00:16:41,769 NINDS. THANKNNDS. 475 00:16:41,769 --> 00:16:45,473 THANK YOU. NINDS. THANK YOU. M 476 00:16:45,473 --> 00:16:55,817 NINDS. THANK YOU. 477 00:17:15,436 --> 00:17:17,472 RECOGNIZE RECENT RETIREES 478 00:17:17,472 --> 00:17:19,674 INCLUDING DAVE OWENS WHO USED TO 479 00:17:19,674 --> 00:17:21,409 SIT IN THIS SEAT AMONG MANY 480 00:17:21,409 --> 00:17:23,511 OTHERS. AND THE MOVE OF OUR 481 00:17:23,511 --> 00:17:25,780 SCIENTIFIC REVIEW STAFF TO CSR 482 00:17:25,780 --> 00:17:27,582 AT THE END OF THIS SLIDE WE 483 00:17:27,582 --> 00:17:29,016 EXTEND OUR APPRECIATION TO ALL 484 00:17:29,016 --> 00:17:31,185 OF THESE PEOPLE FOR THEIR MANY 485 00:17:31,185 --> 00:17:33,621 CONTRIBUTIONS TO NINDS AND OUR 486 00:17:33,621 --> 00:17:38,326 MISSION. THANK YOU. OKAY, 487 00:17:38,326 --> 00:17:39,994 BEFORE WE GET STARTED, I HAVE A 488 00:17:39,994 --> 00:17:43,731 FEW HOUSEKEEPING ITEMS JUST A 489 00:17:43,731 --> 00:17:47,068 REMINDER THAT DAN, FRANCIS, AMY, 490 00:17:47,068 --> 00:17:49,170 KATE, ROY, LYNN, HECTOR AND 491 00:17:49,170 --> 00:17:51,439 GERALDINE, YOU ARE ATTENDING 492 00:17:51,439 --> 00:17:53,908 THIS MEETING AS SUBJECT MATTER 493 00:17:53,908 --> 00:17:54,542 EXPERTS WHICH MEAN YOU CAN 494 00:17:54,542 --> 00:17:56,144 PARTICIPATE FULLY IN ALL THE 495 00:17:56,144 --> 00:17:58,546 DISCUSSIONS BUT CAN'T FORMALLY 496 00:17:58,546 --> 00:18:00,148 VOTE. THANK YOU FOR YOUR 497 00:18:00,148 --> 00:18:00,815 PATIENCE AS WE CONTINUE TO 498 00:18:00,815 --> 00:18:02,984 NAVIGATE THE HHS APPROVAL 499 00:18:02,984 --> 00:18:09,090 PROCESS. THIS SESSION IS VIDEO 500 00:18:09,090 --> 00:18:10,458 CAST AND WILL BE ARCHIVED SO 501 00:18:10,458 --> 00:18:12,593 KEEP THAT IN MIND DURING TODAY'S 502 00:18:12,593 --> 00:18:15,596 MEETING. THERE ARE NINDS STAFF 503 00:18:15,596 --> 00:18:17,064 WHO ARE ATTENDING IN-PERSON TO 504 00:18:17,064 --> 00:18:18,800 THOSE OF YOU AROUND THE TABLE 505 00:18:18,800 --> 00:18:20,334 AND IN THE ROOM MRAIZ PLEASE 506 00:18:20,334 --> 00:18:23,538 MAKE SURE YOU'RE LOGGED ONTO 507 00:18:23,538 --> 00:18:24,872 TEAMS BUT KEEP YOUR COMPUTERS 508 00:18:24,872 --> 00:18:26,774 AND MICROPHONES MUTED FOR THIS 509 00:18:26,774 --> 00:18:27,708 MEETING ANYTHING REQUIRING A 510 00:18:27,708 --> 00:18:29,110 VOTE WILL BE MANAGED THE 511 00:18:29,110 --> 00:18:29,944 OLD-FASHIONED WAY I WILL CALL 512 00:18:29,944 --> 00:18:30,978 FOR A MOTION AND THE MOTION WILL 513 00:18:30,978 --> 00:18:33,648 BE MADE AND SECONDED. THEN, 514 00:18:33,648 --> 00:18:36,450 SINCE WE HAVE ATTENDEES ON TEAMS 515 00:18:36,450 --> 00:18:38,753 I WILL TAKE A VOTE VIA ROLL CALL 516 00:18:38,753 --> 00:18:40,121 TO ENSURE THAT WE HAVE EACH OF 517 00:18:40,121 --> 00:18:44,225 YOUR VOTES RECORDED. ARE THERE 518 00:18:44,225 --> 00:18:52,733 ANY QUESTIONS? OKAY. ON THE 519 00:18:52,733 --> 00:18:55,636 AGENDA WHICH YOU CAN FIND IN THE 520 00:18:55,636 --> 00:18:58,539 ECB UNDER THE NINDS GENERAL TAB 521 00:18:58,539 --> 00:19:01,509 COUNCIL MEETING DATES THROUGH 522 00:19:01,509 --> 00:19:03,644 2027 ARE LISTED AND NOTE THAT 523 00:19:03,644 --> 00:19:05,246 EACH SYNDROME WILL BE ON 524 00:19:05,246 --> 00:19:07,882 WEDNESDAY AND THURSDAY. HOLD 525 00:19:07,882 --> 00:19:09,650 THESE DATES ON YOUR CALENDARS 526 00:19:09,650 --> 00:19:12,553 LET US KNOW IF YOU ANTICIPATE 527 00:19:12,553 --> 00:19:15,122 ANY CONFLICTS. WE'RE HOLDING AN 528 00:19:15,122 --> 00:19:16,524 EXTRA COUNCIL IN AUGUST FOR TWO 529 00:19:16,524 --> 00:19:17,158 REASONS, THERE'S SOME 530 00:19:17,158 --> 00:19:18,459 APPLICATIONS THAT ARE COMING IN 531 00:19:18,459 --> 00:19:20,761 THAT HAD REVIEWS THAT COULDN'T 532 00:19:20,761 --> 00:19:22,330 BE SCHEDULED IN TIME FOR THE 533 00:19:22,330 --> 00:19:24,498 SPRING COUNCIL DUE TO THE DELAYS 534 00:19:24,498 --> 00:19:27,401 WE HAD IN POSTING IN THE FEDERAL 535 00:19:27,401 --> 00:19:29,237 REGISTER AND ADDITIONAL 536 00:19:29,237 --> 00:19:30,404 APPLICATIONS WERE SPECIFICALLY 537 00:19:30,404 --> 00:19:31,906 TARGETED FOR THIS AUGUST COUNCIL 538 00:19:31,906 --> 00:19:33,608 SO THAT WE CAN PROCESS THE 539 00:19:33,608 --> 00:19:38,746 AWARDS USING FISCAL YEAR 2025 540 00:19:38,746 --> 00:19:40,581 FUNDS. EACH ROUND I REPORT TO 541 00:19:40,581 --> 00:19:43,985 YOU ABOUT THE EXPEDITED REVIEW 542 00:19:43,985 --> 00:19:45,653 PROCESS. WHICH THREE 543 00:19:45,653 --> 00:19:46,888 COUNCILMEMBERS ARE DELEGATED TO 544 00:19:46,888 --> 00:19:48,456 APPROVE A SUBSET OF APPLICATIONS 545 00:19:48,456 --> 00:19:52,593 BEFORE THE COUNCIL MEETS. JEN, 546 00:19:52,593 --> 00:19:54,996 JANE AND GYM AGREED TO HANDLE 547 00:19:54,996 --> 00:19:57,832 THIS THIS YEAR. 548 00:19:57,832 --> 00:20:03,638 THANK YOU FOR THAT. SORRY HANK. 549 00:20:03,638 --> 00:20:05,940 >> YEAH, THANK YOU. I THANK YOU 550 00:20:05,940 --> 00:20:08,576 BOTH FOR THE OVERVIEW HERE. AS 551 00:20:08,576 --> 00:20:10,778 WE PREPARE FOR THE DOCTOR TO 552 00:20:10,778 --> 00:20:11,946 ARRIVE I WOULD JUST LIKE TO KNOW 553 00:20:11,946 --> 00:20:15,549 OF THE MANY I DEPARTURES YOU HAD 554 00:20:15,549 --> 00:20:17,218 WHAT FRACTION OF THE NINDS 555 00:20:17,218 --> 00:20:19,220 WORKFORCE IS NO LONGER THERE? 556 00:20:19,220 --> 00:20:21,989 ARE YOU DOWN BY 20%? 25%? WHAT 557 00:20:21,989 --> 00:20:25,059 IS THE FRACTION THAT HAS 558 00:20:25,059 --> 00:20:26,093 DISAPPEARED? IF YOU WILL? 559 00:20:26,093 --> 00:20:28,429 >> ANDREA: WHEN I CALCULATED IT, 560 00:20:28,429 --> 00:20:30,765 IT'S ABOUT 20%. AMY'S NODDING 561 00:20:30,765 --> 00:20:32,700 AND I THINK THAT'S ROUGHLY TRUE 562 00:20:32,700 --> 00:20:36,704 ACROSS NIH, RIGHT? 563 00:20:36,704 --> 00:20:39,607 >> CAN I ASK YOU ARE THERE 564 00:20:39,607 --> 00:20:40,474 PARTICULAR BRANCHES THAT HAVE 565 00:20:40,474 --> 00:20:42,376 BEEN PARTICULARLY AFFECTED BY 566 00:20:42,376 --> 00:20:42,610 THIS? 567 00:20:42,610 --> 00:20:45,313 >> ANDREA: YES ON THAT SLIDE WE 568 00:20:45,313 --> 00:20:46,714 TRIED TO SEPARATE PEOPLE OUT BY 569 00:20:46,714 --> 00:20:50,251 DIVISIONS, AMY, DO YOU WANT TO 570 00:20:50,251 --> 00:21:00,561 SPEAK TO THAT? 571 00:21:02,396 --> 00:21:03,230 >> AMY: DIFFERENT REDUCTIONS 572 00:21:03,230 --> 00:21:06,600 HAVE HURT DIFFERENT GROUPS. AS 573 00:21:06,600 --> 00:21:08,402 WE LOOK AT THIS THE DIVISION OF 574 00:21:08,402 --> 00:21:08,970 NEUROSCIENCE HAVE BEEN 575 00:21:08,970 --> 00:21:12,139 PARTICULARLY HIT BUT ALL OF THE 576 00:21:12,139 --> 00:21:13,541 DIVISIONS HAVE SUFFERED QUITE 577 00:21:13,541 --> 00:21:16,544 QUIET A BLOW. WE THINK THAT THE 578 00:21:16,544 --> 00:21:18,346 DIVISION OF INTRAMURAL RESEARCH 579 00:21:18,346 --> 00:21:21,315 SUSTAINED A SIGNIFICANT HIT. WE 580 00:21:21,315 --> 00:21:24,318 THINK THAT THOSE PEOPLE WILL BE 581 00:21:24,318 --> 00:21:25,286 REINSTATED SO THEY WERE NOT 582 00:21:25,286 --> 00:21:27,388 INCLUDED ON THE SLIDE BUT THEY 583 00:21:27,388 --> 00:21:30,658 HAVE BEEN UNDER EXTRAORDINARY 584 00:21:30,658 --> 00:21:33,027 UNCERTAINTY FOR MONTHS AND SO 585 00:21:33,027 --> 00:21:34,595 WE'LL JUST CONTINUE TO HOPE THAT 586 00:21:34,595 --> 00:21:37,999 THAT SITUATION GETS RESOLVED BUT 587 00:21:37,999 --> 00:21:39,033 THANK YOU FOR YOUR QUESTION. 588 00:21:39,033 --> 00:21:49,577 >> AND THANK YOU, APPRECIATE IT. 589 00:21:49,777 --> 00:21:50,678 >> ANDREA: THANK YOU, I AM GOING 590 00:21:50,678 --> 00:21:53,381 TO BACK UP AND TALK ABOUT THE 591 00:21:53,381 --> 00:21:55,816 REVIEW PROCESS NOW. WE HAD JANE 592 00:21:55,816 --> 00:21:58,419 AND JIM AGREEING TO HANDLE THAT 593 00:21:58,419 --> 00:22:02,089 THIS YEAR AND THIS EXPEDITED 594 00:22:02,089 --> 00:22:03,391 APPROVAL ALLOWS OUR GRANTS 595 00:22:03,391 --> 00:22:04,458 MANAGEMENT BRANCH TO ISSUE THE 596 00:22:04,458 --> 00:22:05,659 AWARDS AHEAD OF SCHEDULE SO THAT 597 00:22:05,659 --> 00:22:08,963 THE RESEARCH CAN GET STARTED THE 598 00:22:08,963 --> 00:22:10,765 EXPEDITED PROCESS TYPICALLY 599 00:22:10,765 --> 00:22:13,367 FOCUSES ON RO 1S AND OTHER 600 00:22:13,367 --> 00:22:14,402 APPLICATIONS WITH SCORES WITHIN 601 00:22:14,402 --> 00:22:15,302 THE PAY LINES THAT HAVE NO 602 00:22:15,302 --> 00:22:17,071 ISSUES THAT NEED TO BE RESOLVED 603 00:22:17,071 --> 00:22:18,272 BEFORE BEING AWARDED AND OUR 604 00:22:18,272 --> 00:22:20,207 ABILITY TO GET THESE AWARDS OUT 605 00:22:20,207 --> 00:22:22,810 QUICKLY IS DUE TO THE EFFORTS OF 606 00:22:22,810 --> 00:22:25,279 OUR DEDICATED NINDS STAFF AND 607 00:22:25,279 --> 00:22:26,614 PROGRAM STAFF ACROSS THREE 608 00:22:26,614 --> 00:22:30,751 DIVISIONS AND OUR GRANTS 609 00:22:30,751 --> 00:22:33,020 MANAGEMENT BRANCH LED BY SHELLY 610 00:22:33,020 --> 00:22:35,423 WILL BURN, ALL THESE PEOPLE 611 00:22:35,423 --> 00:22:37,458 ENSURE THESE MEET THE CRITERIA 612 00:22:37,458 --> 00:22:39,593 FOR EXPEDITING. THIS ROUND WE 613 00:22:39,593 --> 00:22:42,430 HAD 89 APPLICATIONS THAT WERE 614 00:22:42,430 --> 00:22:44,532 EXPEDITED AND IN THE PROCESS OF 615 00:22:44,532 --> 00:22:46,067 BEING ISSUED. THE TRIENNIAL 616 00:22:46,067 --> 00:22:48,636 REPORT, WE SHARED THIS IN THE 617 00:22:48,636 --> 00:22:50,438 ECB AND I JUST WANT TO ASK IF 618 00:22:50,438 --> 00:22:53,474 THERE ARE ANY QUESTIONS OR 619 00:22:53,474 --> 00:23:01,515 CONCERNS ABOUT THAT REPORT? 620 00:23:01,515 --> 00:23:05,186 >> I'LL BE TALKING ABOUT IT A 621 00:23:05,186 --> 00:23:06,053 LITTLE BIT LATER. I'LL BE 622 00:23:06,053 --> 00:23:08,022 MENTIONING SOME DATA ABOUT THAT 623 00:23:08,022 --> 00:23:15,729 A LITTLE BIT LATER AS WELL. 624 00:23:15,729 --> 00:23:17,364 >> ANDREA: IF THERE ARE NO 625 00:23:17,364 --> 00:23:18,766 CONCERNS, I NEED A MOTION TO 626 00:23:18,766 --> 00:23:22,636 APPROVE. 627 00:23:22,636 --> 00:23:24,772 >> SO MOVED. 628 00:23:24,772 --> 00:23:26,407 >> SECOND. 629 00:23:26,407 --> 00:23:27,041 >> ANDREA: THANK YOU. YOU GUYS 630 00:23:27,041 --> 00:23:29,076 PROBABLY CAN'T SEE THIS BUT 631 00:23:29,076 --> 00:23:30,778 THERE'S A BIG PILLAR BLOCK MY 632 00:23:30,778 --> 00:23:33,414 VIEW OF THE SCREEN IN THE 633 00:23:33,414 --> 00:23:34,748 IMMEDIATE DIRECTION. NOW I WILL 634 00:23:34,748 --> 00:23:41,789 CALL FOR A VOTE. AMY? CAN YOU 635 00:23:41,789 --> 00:23:43,991 VERBALLY STATE YOUR, DO WE WANT 636 00:23:43,991 --> 00:23:46,560 THEM TO VERBALLY DO IT? YES, 637 00:23:46,560 --> 00:23:47,561 VERBALLY, PLEASE. 638 00:23:47,561 --> 00:23:51,732 >> YES, IF I CAN LEARN TO TURN 639 00:23:51,732 --> 00:23:55,970 THE MICROPHONE OFF, YES, 640 00:23:55,970 --> 00:24:02,376 APPROV 641 00:24:02,376 --> 00:24:02,610 APPROVE. 642 00:24:02,610 --> 00:24:12,853 >> (YESES). 643 00:24:17,091 --> 00:24:19,927 >> ANDREA: NEXT UP IS DR. JOHN 644 00:24:19,927 --> 00:24:21,762 NGAI AND I WILL TURN IT OTHER TO 645 00:24:21,762 --> 00:24:21,962 HIM. 646 00:24:21,962 --> 00:24:24,231 >> JOHN: I THINK WE'RE RUNNING A 647 00:24:24,231 --> 00:24:25,466 LITTLE BEHIND. I WILL BE BRIEF. 648 00:24:25,466 --> 00:24:28,369 WALTER ASKED FOR A BRIEF UPDATE 649 00:24:28,369 --> 00:24:31,906 ON THE MICRONS PROJECT WHICH WAS 650 00:24:31,906 --> 00:24:35,075 PUBLISHED LAST MONTH. LET ME 651 00:24:35,075 --> 00:24:41,682 SEE THERE, YEAH, SO JUST A VERY 652 00:24:41,682 --> 00:24:42,750 QUICK UPDATE AND HOPEFULLY 653 00:24:42,750 --> 00:24:43,851 THERE'LL BE A LITTLE BIT OF TIME 654 00:24:43,851 --> 00:24:45,486 TO TAKE QUESTIONS. SO LAST 655 00:24:45,486 --> 00:24:48,355 MONTH A GROUP OF PAPERS WERE 656 00:24:48,355 --> 00:24:49,924 PUBLISHED FROM THE MICRONS 657 00:24:49,924 --> 00:24:50,758 PROJECT, THE MACHINE 658 00:24:50,758 --> 00:24:52,226 INTELLIGENCE FROM CORTICAL 659 00:24:52,226 --> 00:24:53,894 NETWORKS PROJECT AND THIS WAS 660 00:24:53,894 --> 00:24:56,397 ESTABLISHING FUNCTIONAL 661 00:24:56,397 --> 00:24:57,464 CONNECTIVITY OF THE MOUSE VISUAL 662 00:24:57,464 --> 00:24:59,833 CORTEX THIS WAS A LARGE 663 00:24:59,833 --> 00:25:00,768 CONSORTIUM PROJECT ORGANIZED 664 00:25:00,768 --> 00:25:02,536 INITIALLY BY THE INTELLIGENCE 665 00:25:02,536 --> 00:25:08,709 AGENCY IRPA. IT COMPRISED OVER 666 00:25:08,709 --> 00:25:10,778 150 RESEARCHERS. AGAIN, 667 00:25:10,778 --> 00:25:14,748 INITIALLY STARTED BY ARPA AND 668 00:25:14,748 --> 00:25:17,885 THEN BY OTHERS. IT WAS LED BY 669 00:25:17,885 --> 00:25:21,789 THREE INSTITUTIONS, IN SEATTLE, 670 00:25:21,789 --> 00:25:23,123 PRINCETON, NEW JERSEY AND IN 671 00:25:23,123 --> 00:25:24,725 HOUSTON FROM THE COLLEGE OF 672 00:25:24,725 --> 00:25:28,028 MEDICINE. THEY PERFORMED AN EM 673 00:25:28,028 --> 00:25:30,464 RECONSTRUCTION OF ONE CUBIC 674 00:25:30,464 --> 00:25:31,432 MILLIMETER OF MOUSE CORTEX THIS 675 00:25:31,432 --> 00:25:34,468 TOOK THE ANALYSIS OF OVER ABOUT 676 00:25:34,468 --> 00:25:38,505 28,000 SECTIONS, THE RAW DATA 677 00:25:38,505 --> 00:25:40,841 ITSELF COMPRISED ABOUT TWO PED 678 00:25:40,841 --> 00:25:44,311 DA BITES OF DATA AND THROUGH 679 00:25:44,311 --> 00:25:45,879 THIS EFFORT THEY WERE ABLE TO 680 00:25:45,879 --> 00:25:50,084 LOOK AT CELLS AND OVER 500 681 00:25:50,084 --> 00:25:50,985 MILLION SYNAPSES THIS IS GETTING 682 00:25:50,985 --> 00:25:53,354 AT THE WIRING DIAGRAM OF THE 683 00:25:53,354 --> 00:25:55,489 BRAIN AND THE ULTIMATE GOAL IS 684 00:25:55,489 --> 00:25:57,491 TO UNDERSTANDING HOW THIS WIRE 685 00:25:57,491 --> 00:25:58,892 DIAGRAM SERVES ACTUAL 686 00:25:58,892 --> 00:26:00,928 COMPUTATIONS. SO THIS WASN'T 687 00:26:00,928 --> 00:26:03,397 JUST A STATIC MAP OF CORTEX. 688 00:26:03,397 --> 00:26:06,667 THIS IS THE MOST COMPREHENSIVE 689 00:26:06,667 --> 00:26:07,601 CHARACTERIZATION OF THE MILLION 690 00:26:07,601 --> 00:26:10,804 BRAIN CELL VOLUME SO FAR BUT 691 00:26:10,804 --> 00:26:13,274 WHAT WHAT THEY DID BEFORE THEY 692 00:26:13,274 --> 00:26:17,378 TOOK THIS PROCESSING. 693 00:26:17,378 --> 00:26:19,179 THEY SHOWED THE MOUSE VIDEO 694 00:26:19,179 --> 00:26:21,181 CLIPS OF VARIOUS SCENES 695 00:26:21,181 --> 00:26:22,950 INCLUDING NATURALISTIC SCENES IN 696 00:26:22,950 --> 00:26:26,453 A MOUSE THAT EXPRESSED A CALCIUM 697 00:26:26,453 --> 00:26:28,522 INDICATOR SO THEY HAD ACTIVITY. 698 00:26:28,522 --> 00:26:30,424 THEY WERE ABLE TO MONITOR 699 00:26:30,424 --> 00:26:32,059 ACTIVITY FROM 76,000 NEURONS AND 700 00:26:32,059 --> 00:26:34,762 OVERLAY THAT ONTO THE 701 00:26:34,762 --> 00:26:36,297 FUNCTIONAL, ONTO THE ANATOMICAL 702 00:26:36,297 --> 00:26:37,631 MAP. AND THIS ALLOWS THEM TO DO 703 00:26:37,631 --> 00:26:40,034 A NUMBER OF THINGS INCLUDING 704 00:26:40,034 --> 00:26:41,869 BUILDING A DIGITAL TWIN OF THIS 705 00:26:41,869 --> 00:26:44,471 CUBIC MILLIMETER AND THEY 706 00:26:44,471 --> 00:26:45,272 ESTABLISHED A FOUNDATION MODEL 707 00:26:45,272 --> 00:26:48,142 OF NEURAL ACTIVITY THAT CAN 708 00:26:48,142 --> 00:26:49,910 PREDICT RESPONSES TO NOVEL 709 00:26:49,910 --> 00:26:51,045 STIMULUS TYPES SO THIS IS REALLY 710 00:26:51,045 --> 00:26:53,047 THE HOLY GRAIL OF NEUROSCIENCE 711 00:26:53,047 --> 00:26:54,682 WHICH IS TO CONNECT STRUCTURE 712 00:26:54,682 --> 00:26:56,684 AND FUNCTION OF THESE CIRCUITS. 713 00:26:56,684 --> 00:26:58,752 AND THIS REALLY SETS THE STAGE 714 00:26:58,752 --> 00:27:00,454 FOR BUILDING THE BRAIN CONNECTS 715 00:27:00,454 --> 00:27:03,424 PROJECT. THIS IS ONE OF OUR 716 00:27:03,424 --> 00:27:05,426 THREE TRANSFORMATIVE PROJECTS TO 717 00:27:05,426 --> 00:27:07,494 GROUND THIS WITH A WIRING 718 00:27:07,494 --> 00:27:08,896 DIAGRAM THAT SYNAPSE SOLUTION AN 719 00:27:08,896 --> 00:27:10,731 ENTIRE MOUSE BRAIN AT THE 720 00:27:10,731 --> 00:27:12,433 PROJECTION OF A RESOLUTION FOR 721 00:27:12,433 --> 00:27:14,034 AN ENTIRE HUMAN. NOW THIS 722 00:27:14,034 --> 00:27:16,837 BUILDS ON PREVIOUS WORK THAT'S 723 00:27:16,837 --> 00:27:21,775 BEEN PUBLISHED, SPOUPPORTED BY E 724 00:27:21,775 --> 00:27:23,644 BRAIN INITIATIVE. THAT PROVIDES 725 00:27:23,644 --> 00:27:26,747 A COMPLETE CELL ANALYSIS OF THE 726 00:27:26,747 --> 00:27:29,717 MOUSE BRAIN AS WELL AS OF THE 727 00:27:29,717 --> 00:27:31,952 NONHUMAN PRY MAT BRAINS AND THE 728 00:27:31,952 --> 00:27:34,121 GROUP JUST RECENTLY MADE PUBLIC 729 00:27:34,121 --> 00:27:35,789 THIS WILL BE CALLED THE BRAIN 730 00:27:35,789 --> 00:27:36,590 KNOWLEDGE PLATFORM WHICH HAS 731 00:27:36,590 --> 00:27:39,893 DATA CELL TYPE DATA, MOLECULAR 732 00:27:39,893 --> 00:27:42,763 DATA FROM OVER 12 SPECIES TO ALL 733 00:27:42,763 --> 00:27:44,331 OPEN ACCESS. 734 00:27:44,331 --> 00:27:46,400 IT'S REALLY THE START IN OUR 735 00:27:46,400 --> 00:27:47,801 EFFORT TO PROVIDE LARGE-SCALE 736 00:27:47,801 --> 00:27:49,870 RESOURCES TO THE COMMUNITY TO 737 00:27:49,870 --> 00:27:52,506 EMPOWER AND ACCELERATE RESEARCH 738 00:27:52,506 --> 00:27:55,309 FOR ALL. NOW AGAIN, THESE TWO 739 00:27:55,309 --> 00:27:57,511 PROJECTS, THE BRAIN INITIATIVE 740 00:27:57,511 --> 00:28:00,914 CELL CENSUS PROJECT WHICH IS 741 00:28:00,914 --> 00:28:02,249 FOCUSING ON BIG BRAINS TOGETHER 742 00:28:02,249 --> 00:28:05,419 WITH THE CONNECTS PROGRAM SO THE 743 00:28:05,419 --> 00:28:07,688 WIRING PROGRAM PLUS THIS GIVES 744 00:28:07,688 --> 00:28:10,491 US THE GROUND TRUTH FOR HOW 745 00:28:10,491 --> 00:28:12,025 CIRCUITS MIGHT COMPUTE AND THE 746 00:28:12,025 --> 00:28:14,762 THIRD PROJECT WHICH I DON'T HAVE 747 00:28:14,762 --> 00:28:17,331 TIME TO MENTION TODAY IS THE 748 00:28:17,331 --> 00:28:19,933 PRECISION PERTAIN CELL ACCESS 749 00:28:19,933 --> 00:28:22,603 AND THIS IS TO HAVE TOOLS AT 750 00:28:22,603 --> 00:28:23,904 SCALE FOR THE SPECIFIC CELL 751 00:28:23,904 --> 00:28:27,641 TYPES THAT ARE IDENTIFIED 752 00:28:27,641 --> 00:28:31,078 MOLECULARLY FROM THE BICAN 753 00:28:31,078 --> 00:28:33,847 PROJECT AS WELL AS CIRCUITS TO 754 00:28:33,847 --> 00:28:35,849 ALLOW US PRECISION ACCESS. 755 00:28:35,849 --> 00:28:37,351 TO BETTER UNDERSTAND NEURAL 756 00:28:37,351 --> 00:28:38,218 CIRCUITS AND HEALTH AND DISEASE 757 00:28:38,218 --> 00:28:42,923 AND TOGETHER THESE WILL LAY THE 758 00:28:42,923 --> 00:28:44,158 FOUNDATION FOR FUTURE THERAPIES 759 00:28:44,158 --> 00:28:45,225 SO IF YOU WANT TO SEE WHAT WE'VE 760 00:28:45,225 --> 00:28:48,162 BEEN DOING FOR THE LAST TEN 761 00:28:48,162 --> 00:28:50,597 YEARS OR SO, WE'RE CELEBRATING 762 00:28:50,597 --> 00:28:52,699 THE 10TH ANNIVERSARY, YOU CAN 763 00:28:52,699 --> 00:28:54,101 PICK UP THIS AND I WILL STOP 764 00:28:54,101 --> 00:28:56,503 HERE AND IF THERE'S TIME FOR 765 00:28:56,503 --> 00:28:58,739 QUESTIONS, I AM HAPPY TO, KEEP 766 00:28:58,739 --> 00:29:01,775 YOUR EYES PEELED ON THE 767 00:29:01,775 --> 00:29:03,811 LITERATURE NEXT WEEK. I AM 768 00:29:03,811 --> 00:29:05,012 HAPPY TO TAKE QUESTIONS. 769 00:29:05,012 --> 00:29:06,580 >> WALTER: THANKS A LOT, JOHN, I 770 00:29:06,580 --> 00:29:09,883 THINK, YOU KNOW, THIS IS THE 771 00:29:09,883 --> 00:29:10,751 MOST AMAZING PROJECT THAT WE'VE 772 00:29:10,751 --> 00:29:14,755 EVER SEEN IN NEUROSCIENCE. SO 773 00:29:14,755 --> 00:29:17,491 THANKS FOR LEADING IT. IT JUST 774 00:29:17,491 --> 00:29:25,165 KEEPS COMING. THE GOODIES KEEP 775 00:29:25,165 --> 00:29:26,767 COMING. THANKS VERY MUCH. 776 00:29:26,767 --> 00:29:30,404 DR. WHAT TA CHARIA IS ON. CAN 777 00:29:30,404 --> 00:29:31,505 YOU HEAR US? 778 00:29:31,505 --> 00:29:33,307 >> JAYANTA: I CAN HEAR YOU, CAN 779 00:29:33,307 --> 00:29:34,274 YOU HEAR ME? 780 00:29:34,274 --> 00:29:36,477 >> WALTER: WE'RE REAL PLEASED TO 781 00:29:36,477 --> 00:29:40,681 HAVE DR. JAYANTA WHAT TA CHARIA 782 00:29:40,681 --> 00:29:44,518 HERE. THE 18TH DIRECTOR OF THE 783 00:29:44,518 --> 00:29:45,118 NATIONAL INSTITUTES OF HEALTH 784 00:29:45,118 --> 00:29:49,289 CONFIRMED BY THE SENATE IN MARCH 785 00:29:49,556 --> 00:29:51,925 2025. HE'S A PH.D., LONG-TERM 786 00:29:51,925 --> 00:29:52,993 PROFESSOR KNOWN FOR HIS WORKING 787 00:29:52,993 --> 00:29:54,795 ON AGING, CHRONIC DISEASE AND 788 00:29:54,795 --> 00:30:00,334 HEALTH POLL SIX -- POLICY. 789 00:30:00,334 --> 00:30:02,202 HE PLANS TO BRING A STRONG FOCUS 790 00:30:02,202 --> 00:30:04,905 ON ADDRESSING AMERICA'S CHRONIC 791 00:30:04,905 --> 00:30:06,740 DISEASE CRISIS. HE'S SUBMITTED 792 00:30:06,740 --> 00:30:09,610 TO FOSTERING OPEN SCIENTIFIC 793 00:30:09,610 --> 00:30:10,477 DIALOGUE AND ADVANCING RESEARCH 794 00:30:10,477 --> 00:30:13,146 THAT DELIVERS REAL WORLD IMPACT 795 00:30:13,146 --> 00:30:16,350 AS I MENTIONED, HE'S IN A 796 00:30:16,350 --> 00:30:17,784 LEADERSHIP POSITION THAT IS 797 00:30:17,784 --> 00:30:18,952 REALLY GOING TO HELP DETERMINE 798 00:30:18,952 --> 00:30:21,288 WHAT WE AS AN INSTITUTE CAN DO 799 00:30:21,288 --> 00:30:23,490 FOR THE PEOPLE WITH NEUROLOGICAL 800 00:30:23,490 --> 00:30:25,592 DISORDERS AND FOR THE FOLKS 801 00:30:25,592 --> 00:30:27,361 WORKING HARD TO UNDERSTAND THE 802 00:30:27,361 --> 00:30:29,563 BRAIN WHICH IS THE ORGAN AS JOHN 803 00:30:29,563 --> 00:30:32,833 JUST TOLD YOU THAT MAKES US 804 00:30:32,833 --> 00:30:33,901 HUMAN, MAKES US THE INDIVIDUALS 805 00:30:33,901 --> 00:30:35,135 WE ARE AND NOT JUST THE SPECIES 806 00:30:35,135 --> 00:30:37,204 WE ARE. SO JAY, IT'S A PLEASURE 807 00:30:37,204 --> 00:30:39,907 TO HAVE YOU AND WE LOOK FORWARD 808 00:30:39,907 --> 00:30:43,243 TO YOUR ADDRESS 809 00:30:43,243 --> 00:30:47,114 >> KAT 810 00:30:47,114 --> 00:30:48,448 >> JAYANTA: THANK YOU, WALTER, I 811 00:30:48,448 --> 00:30:49,917 HAVE A SLIDE DECK I WANT TO 812 00:30:49,917 --> 00:30:51,919 SHARE I WILL SEE IF CAN I GET 813 00:30:51,919 --> 00:30:53,754 THAT WORKING. THERE IT IS, 814 00:30:53,754 --> 00:30:54,655 FANTASTIC. 815 00:30:54,655 --> 00:30:57,891 AS WALTER SAID, I'M THE NEW NIH 816 00:30:57,891 --> 00:31:00,494 DIRECTOR AND I, ALTHOUGH I DON'T 817 00:31:00,494 --> 00:31:01,695 HAVE A BACKGROUND IN 818 00:31:01,695 --> 00:31:02,763 NEUROLOGICAL DISORDERS IT'S 819 00:31:02,763 --> 00:31:04,398 SOMETHING I'VE BEEN VERY, VERY 820 00:31:04,398 --> 00:31:06,600 INTERESTED IN JUST FOLLOWING MY 821 00:31:06,600 --> 00:31:09,903 ENTIRE CAREER AND IT'S ONE OF 822 00:31:09,903 --> 00:31:12,306 THESE AMAZING THINGS THAT I'M 823 00:31:12,306 --> 00:31:14,441 GOING TO BE ABLE TO LEARN FROM 824 00:31:14,441 --> 00:31:16,577 YOU ALL. I JUST SAW A LITTLE 825 00:31:16,577 --> 00:31:17,644 BIT ABOUT THE BRAIN INITIATIVE 826 00:31:17,644 --> 00:31:19,846 AND I'VE BEEN FOLLOWING THAT FOR 827 00:31:19,846 --> 00:31:21,548 A FEW YEARS AS WELL AND LIKE 828 00:31:21,548 --> 00:31:22,716 WALTER I SHARE THE EXCITEMENT 829 00:31:22,716 --> 00:31:24,718 THAT THERE IS ABOUT THE ADVANCES 830 00:31:24,718 --> 00:31:26,386 IN KNOWLEDGE THAT WE'VE HAD. I 831 00:31:26,386 --> 00:31:27,821 WANT TO MAKE SURE THAT WE 832 00:31:27,821 --> 00:31:33,594 CONTINUE THAT. NEXT SLIDE, 833 00:31:33,594 --> 00:31:35,329 PLEASE SO I WANTED TO JUST START 834 00:31:35,329 --> 00:31:36,863 BY GIVING A FEW LEADERSHIP 835 00:31:36,863 --> 00:31:41,368 UPDATES. I WILL TALK ABOUT MY 836 00:31:41,368 --> 00:31:42,169 VISION. AND THEN SOME PROBLEMS 837 00:31:42,169 --> 00:31:45,372 I THINK WE NEED TO GET 838 00:31:45,372 --> 00:31:47,774 ADDRESSED. SO THE NIH OBVIOUSLY 839 00:31:47,774 --> 00:31:49,576 HAS BEEN THROUGH A TREMENDOUSLY 840 00:31:49,576 --> 00:31:51,645 TURBULENT TIME OVER THE LAST FEW 841 00:31:51,645 --> 00:31:54,681 MONTHS. AND WE'VE TRANSITIONED 842 00:31:54,681 --> 00:31:57,884 WITH NEW LEADERSHIP. SO MATT 843 00:31:57,884 --> 00:32:00,320 MEMO LEE WILL BE THE PRINCIPAL 844 00:32:00,320 --> 00:32:02,656 DEPUTY DIRECTOR. SCENE THAT 845 00:32:02,656 --> 00:32:05,559 KRAN STON IS REPLACING THE CHIEF 846 00:32:05,559 --> 00:32:09,363 OF STAFF. ERIC SH NAB L. THE 847 00:32:09,363 --> 00:32:13,734 CHIEF OPERATING OFFICER AND 848 00:32:13,734 --> 00:32:14,735 JAMES MCELROY. WE HAVE 849 00:32:14,735 --> 00:32:16,036 LEADERSHIP TRANSITIONS THAT ARE 850 00:32:16,036 --> 00:32:18,772 GOING TO, I'M GOING TO WORK ON 851 00:32:18,772 --> 00:32:19,940 VERY HEAVILY. 852 00:32:19,940 --> 00:32:20,841 BUT IN THE MEANTIME WE HAVE SOME 853 00:32:20,841 --> 00:32:22,209 FANTASTIC PEOPLE WHO STEPPED UP 854 00:32:22,209 --> 00:32:32,853 AS ACTING DIRECTOR AT NINR, NIMH 855 00:32:36,657 --> 00:32:37,024 DVR 856 00:32:37,024 --> 00:32:39,292 D BUT IT'S A CHANCE TO MOVE THE 857 00:32:39,292 --> 00:32:41,161 NIH WITH MORE POLITICAL SUPPORT 858 00:32:41,161 --> 00:32:43,130 ACROSS THE POLITICAL SPECTRUM. 859 00:32:43,130 --> 00:32:44,431 FOCUSED ON THE HEALTH NEEDS OF 860 00:32:44,431 --> 00:32:48,068 THE AMERICAN PEOPLE. NEXT 861 00:32:48,068 --> 00:32:50,103 SLIDE, PLEASE. BEFORE I GET TO 862 00:32:50,103 --> 00:32:52,739 MY VISION I WANTED TO PREFACE IT 863 00:32:52,739 --> 00:32:55,909 WITH THE SENSE OF THE PROBLEMS I 864 00:32:55,909 --> 00:32:59,279 SEE AS THE NIH FACES AND SCIENCE 865 00:32:59,279 --> 00:33:01,848 MORE GENERALLY. DURING THE 866 00:33:01,848 --> 00:33:05,318 PANDEMIC, A LOT OF AMERICANS 867 00:33:05,318 --> 00:33:15,729 LOST THEIR TRUST IN THE 868 00:33:16,096 --> 00:33:17,164 SCIENTISTS TO DO WHAT'S BEST 869 00:33:17,164 --> 00:33:18,765 INTEREST OF THE AMERICAN PEOPLE. 870 00:33:18,765 --> 00:33:21,968 THIS IS FROM A STUDY IN 2024. 871 00:33:21,968 --> 00:33:27,874 BEFORE THE PANDEMIC MAYBE 12-13% 872 00:33:27,874 --> 00:33:29,876 OF AMERICANS THOUGHT... HAD LOW 873 00:33:29,876 --> 00:33:31,978 CONFIDENCE FOR SCIENTISTS TO DO 874 00:33:31,978 --> 00:33:33,814 WHAT'S BEST FOR THE PUBLIC NOW 875 00:33:33,814 --> 00:33:35,882 WE'RE TALKING IN THE ORDER OF 876 00:33:35,882 --> 00:33:37,818 23%. ONE IN FOUR AMERICANS HAVE 877 00:33:37,818 --> 00:33:39,486 NO TRUST WHATSOEVER THAT 878 00:33:39,486 --> 00:33:40,654 SCIENTISTS DO WHAT IS BEST FOR 879 00:33:40,654 --> 00:33:43,056 THE AMERICAN PEOPLE. THIS IS 880 00:33:43,056 --> 00:33:45,225 IMPORTANT BECAUSE, THE AMERICAN 881 00:33:45,225 --> 00:33:48,395 PEOPLE THAT PAY FOR OUR SCIENCE, 882 00:33:48,395 --> 00:33:50,731 THAT ARE THE... THAT POTENTIALLY 883 00:33:50,731 --> 00:33:52,065 USE THE SCIENTIFIC RESULTS WE 884 00:33:52,065 --> 00:33:54,568 HAVE. IF WE DON'T ADDRESS THIS 885 00:33:54,568 --> 00:33:57,370 PROBLEM BY ADDRESSING THE THINGS 886 00:33:57,370 --> 00:33:59,372 THAT LED TO THIS LACK OF TRUST, 887 00:33:59,372 --> 00:34:00,974 WE'RE GOING TO CONTINUE TO HAVE 888 00:34:00,974 --> 00:34:02,743 THESE TURBULENT TIMES IN THE 889 00:34:02,743 --> 00:34:07,180 FUTURE. NEXT SLIDE, PLEASE. SO 890 00:34:07,180 --> 00:34:09,082 LET ME TALK A LITTLE BIT ABOUT 891 00:34:09,082 --> 00:34:14,087 MY VISION FOR THE NIH. AND I 892 00:34:14,087 --> 00:34:15,922 HAVE BASICALLY FIVE IDEAS FOR 893 00:34:15,922 --> 00:34:17,491 REFORMS THAT WILL HELP RESTORE 894 00:34:17,491 --> 00:34:22,095 THIS PUBLIC TRUST. NEXT SLIDE, 895 00:34:22,095 --> 00:34:25,298 PLEASE. FIRST, WE HAVE TO FOCUS 896 00:34:25,298 --> 00:34:29,136 ON THE THINGS THAT MOST IMPACT 897 00:34:29,136 --> 00:34:32,239 THE AMERICAN PEOPLE. AT NINDS I 898 00:34:32,239 --> 00:34:33,406 DON'T THINK YOU HAVE ANY TROUBLE 899 00:34:33,406 --> 00:34:36,076 WITH THAT. YOU ALL ARE FOCUSED 900 00:34:36,076 --> 00:34:39,479 ON EXACTLY PROBLEMS THAT SO MANY 901 00:34:39,479 --> 00:34:41,782 AMERICAN FOLKS, AMERICAN PEOPLE 902 00:34:41,782 --> 00:34:43,350 HAVE. THE CHRONIC DISEASE 903 00:34:43,350 --> 00:34:45,919 PROBLEM IS TO STRANGER TO THE 904 00:34:45,919 --> 00:34:49,256 NINDS AND IT'S EXACTLY THE KIND 905 00:34:49,256 --> 00:34:51,691 OF RESEARCH WE OUGHT TO DO SO 906 00:34:51,691 --> 00:34:55,428 THAT WE CAN ADDRESS THESE HEALTH 907 00:34:55,428 --> 00:34:57,497 NEEDS FROM STROKE TO 908 00:34:57,497 --> 00:34:59,733 NEUROLOGICAL DISORDERS TO 909 00:34:59,733 --> 00:35:01,902 ALZHEIMER'S DISEASE. IF WE 910 00:35:01,902 --> 00:35:04,104 FOCUS ON THOSE ITEMS THAT MOST 911 00:35:04,104 --> 00:35:06,373 IMPACT THE HEALTH AND WELL-BEING 912 00:35:06,373 --> 00:35:08,742 OF AMERICANS, AMERICANS WILL 913 00:35:08,742 --> 00:35:09,776 START TO TRUST US ONCE AGAIN. 914 00:35:09,776 --> 00:35:14,447 IF YOU LOOK AT THE STATISTICS 915 00:35:14,447 --> 00:35:16,183 THAT, ON LONGEVITY FOR INSTANCE, 916 00:35:16,183 --> 00:35:17,717 THERE WAS NO INCREASE IN 917 00:35:17,717 --> 00:35:18,752 LONGEVITY IN THE UNITED STATES 918 00:35:18,752 --> 00:35:22,455 BETWEEN 2012-2019 AND OF COURSE 919 00:35:22,455 --> 00:35:24,825 DURING THE PANDEMIC THERE WAS A 920 00:35:24,825 --> 00:35:27,928 COLLAPSE IN LIFE EXPECTANCY, SO 921 00:35:27,928 --> 00:35:34,835 MUCH OF THE FOCUS CAME ONCO 922 00:35:34,835 --> 00:35:37,737 COVID THAT AMERICANS LOST THEIR 923 00:35:37,737 --> 00:35:39,506 CONFIDENCE THAT WE WERE FOCUSING 924 00:35:39,506 --> 00:35:41,341 ON OTHER ASPECTS OF THEIR HEALTH 925 00:35:41,341 --> 00:35:42,776 THAT CONTINUED DURING COVID AND 926 00:35:42,776 --> 00:35:44,411 IN FACT GOT WORSE. 927 00:35:44,411 --> 00:35:45,245 OF COURSE THAT'S NOT ALL BAD 928 00:35:45,245 --> 00:35:46,880 NEWS WE ACTUALLY DID FOCUS ON 929 00:35:46,880 --> 00:35:49,416 LOTS OF ITEMS THAT IMPROVED 930 00:35:49,416 --> 00:35:50,450 AMERICAN HEALTH BUT WE HAVEN'T 931 00:35:50,450 --> 00:35:52,152 TRANSLATED THAT INTO THE 932 00:35:52,152 --> 00:35:53,153 POPULATION AT LARGE. SO WE HAVE 933 00:35:53,153 --> 00:35:59,893 A LOT OF WORK TO DO, NEXT SLIDE, 934 00:35:59,893 --> 00:36:00,827 PLEASE. EVERY 40 SECONDS 935 00:36:00,827 --> 00:36:03,196 SOMEONE HAS A STROKE. IN THE 936 00:36:03,196 --> 00:36:04,197 UNITED STATES. 50 MILLION 937 00:36:04,197 --> 00:36:07,968 AMERICAN ADULTS LIVE IN CHRONIC 938 00:36:07,968 --> 00:36:09,669 PAIN. MORE THAN 7 MILLION 939 00:36:09,669 --> 00:36:10,337 AMERICANS HAVE ALZHEIMER'S 940 00:36:10,337 --> 00:36:11,671 DISEASE OF COURSE THAT IMPACTS 941 00:36:11,671 --> 00:36:13,840 NOT JUST THE PATIENTS BUT THEIR 942 00:36:13,840 --> 00:36:16,042 FAMILIES AND THEIR CAREGIVERS. 943 00:36:16,042 --> 00:36:17,911 ALMOST A MILLION PEOPLE IN THE 944 00:36:17,911 --> 00:36:21,181 U.S. LIVE WITH PARKINSON'S 945 00:36:21,181 --> 00:36:23,683 DISEASE AND IN 2030 IT'S TO BE 946 00:36:23,683 --> 00:36:26,086 RAISED BY 1.2 MILLION. YOU ALL 947 00:36:26,086 --> 00:36:27,787 KNOW THE PROBLEMS THAT NEED TO 948 00:36:27,787 --> 00:36:29,456 BE ADDRESSED. THESE STATISTICS 949 00:36:29,456 --> 00:36:33,360 ARE JUST NUMBERS. BUT THEY 950 00:36:33,360 --> 00:36:34,160 REPRESENT SUFFERING ON A MASS 951 00:36:34,160 --> 00:36:36,129 SCALE AND THEY'RE NOT GOING TO 952 00:36:36,129 --> 00:36:38,298 GET, IF THE DEMOGRAPHIC 953 00:36:38,298 --> 00:36:39,733 ESTIMATES ARE RIGHT THEY'RE NOT 954 00:36:39,733 --> 00:36:42,202 GOING TO GO AWAY IN THE COMES 955 00:36:42,202 --> 00:36:43,270 YEARS THEY'RE JUST GOING TO GROW 956 00:36:43,270 --> 00:36:46,206 AS THE POPULATION GETS OLDER. 957 00:36:46,206 --> 00:36:48,241 NEXT SLIDE, PLEASE. THE 958 00:36:48,241 --> 00:36:49,442 ECONOMIC IMPACT OF THESE 959 00:36:49,442 --> 00:36:52,045 PROBLEMS IS ABSOLUTELY ENORMOUS 960 00:36:52,045 --> 00:36:53,647 AS WELL THE HEALTH AND LONG-TERM 961 00:36:53,647 --> 00:36:55,715 CARE COSTS FOR ALZHEIMER'S 962 00:36:55,715 --> 00:36:57,117 DISEASE PATIENTS AND PATIENTS 963 00:36:57,117 --> 00:36:59,786 WITH OTHER DEMENTIAS WILL REACH 964 00:36:59,786 --> 00:37:02,656 384 BILLION DOLLARS THIS YEAR. 965 00:37:02,656 --> 00:37:05,725 THE VALUE OF CARE PROVIDED BY 966 00:37:05,725 --> 00:37:07,160 UNPAID CAREGIVERS WITH, FOR 967 00:37:07,160 --> 00:37:09,195 PEOPLE WITH DEMENTIA IS ON THE 968 00:37:09,195 --> 00:37:13,533 ORDER OF 400 BILLION DOLLARS IN 969 00:37:13,533 --> 00:37:15,368 2024. COMBINED THE INDIRECT AND 970 00:37:15,368 --> 00:37:16,503 DIRECT COST OF PARKINSON'S 971 00:37:16,503 --> 00:37:18,672 DISEASE ARE ESTIMATED TO BE ON 972 00:37:18,672 --> 00:37:20,073 THE ORDER OF 50 BILLION DOLLARS 973 00:37:20,073 --> 00:37:24,978 IN 2020. AND STROKE, ANOTHER 56 974 00:37:24,978 --> 00:37:26,413 BILLION DOLLARS THESE ARE 975 00:37:26,413 --> 00:37:30,617 PROBLEMS THAT NOT ONLY IMPACT 976 00:37:30,617 --> 00:37:32,886 THE LIVES OF THE PATIENTS, THE 977 00:37:32,886 --> 00:37:33,720 LIVES OF THE CAREGIVERS AND 978 00:37:33,720 --> 00:37:38,224 THEIR FAMILIES BUT ALSO IMPACT 979 00:37:38,224 --> 00:37:44,564 THE BOTTOM LINE OF THE UNITED 980 00:37:44,564 --> 00:37:45,865 STATES. A HUGE CHUNK OF 981 00:37:45,865 --> 00:37:48,535 MEDICARE EXPENDITURES GOES TO 982 00:37:48,535 --> 00:37:50,770 EXACTLY THIS KIND OF CAREGIVING. 983 00:37:50,770 --> 00:37:54,774 TO THIS KIND OF CARE. ADVANCES 984 00:37:54,774 --> 00:37:56,376 IN OUR KNOWLEDGE AND OUR ABILITY 985 00:37:56,376 --> 00:37:59,179 TO PREVENT AND TREAT ALZHEIMER'S 986 00:37:59,179 --> 00:38:00,180 FOR INSTANCE WOULD BE 987 00:38:00,180 --> 00:38:02,983 TRANSFORMATIVE ON MEDICARE 988 00:38:02,983 --> 00:38:06,252 BUDGETS. THESE ARE FUNDAMENTAL 989 00:38:06,252 --> 00:38:08,855 ISSUES THAT IF WE CAN MAKE 990 00:38:08,855 --> 00:38:09,990 PROGRESS ON THEM WOULD BENEFIT 991 00:38:09,990 --> 00:38:13,093 EVERY AMERICAN. NEXT SLIDE, 992 00:38:13,093 --> 00:38:19,933 PLEASE. SO THE FIRST PART OF MY 993 00:38:19,933 --> 00:38:22,302 VISION IS TO FOCUS ON THOSE 994 00:38:22,302 --> 00:38:24,004 ITEMS THAT PRIMARILY IMPACT 995 00:38:24,004 --> 00:38:26,272 AMERICAN HEALTH AS I SAID NINDS 996 00:38:26,272 --> 00:38:27,207 IS ALREADY DOING AN EXCELLENT 997 00:38:27,207 --> 00:38:29,042 JOB AT THIS. THE SECOND PART OF 998 00:38:29,042 --> 00:38:32,178 MY VISION IS TO ENSURE RELIABLE 999 00:38:32,178 --> 00:38:35,815 RESULTS. THE NIH SUPPORTED 1000 00:38:35,815 --> 00:38:38,785 SCIENCE SHOULD BE REPRODUCIBLE, 1001 00:38:38,785 --> 00:38:39,452 GENERALIZABLE, UNFORTUNATELY, 1002 00:38:39,452 --> 00:38:41,788 THIS HAS BEEN A MAJOR PROBLEM 1003 00:38:41,788 --> 00:38:45,125 NOT JUST FOR NINDS BUT FOR 1004 00:38:45,125 --> 00:38:46,326 BASICALLY ALMOST ALL THE 1005 00:38:46,326 --> 00:38:49,863 BIOMEDICAL SCIENCES. NEXT 1006 00:38:49,863 --> 00:38:54,768 SLIDE, PLEASE. IN 2005, MY 1007 00:38:54,768 --> 00:38:57,771 COLLEAGUE JOHNNY AT STANFORD 1008 00:38:57,771 --> 00:38:58,571 UNIVERSITY PUBLISHED A PAPER 1009 00:38:58,571 --> 00:39:01,141 WITH THE TITLE WHILE MOST 1010 00:39:01,141 --> 00:39:02,776 PUBLISHED RESEARCH FINDINGS ARE 1011 00:39:02,776 --> 00:39:06,780 FALSE. THE BASIC IDEA IS THAT 1012 00:39:06,780 --> 00:39:10,316 THE SCIENTIFIC STANDARDS WE USE 1013 00:39:10,316 --> 00:39:13,086 ON P-VALUES AND OTHER SORT OF 1014 00:39:13,086 --> 00:39:16,322 STANDARDS AND THE INCENTIVES 1015 00:39:16,322 --> 00:39:18,858 THAT SCIENTISTS HAVE TO PUBLISH 1016 00:39:18,858 --> 00:39:21,327 IN JOURNALS DO NOT GUARANTEE 1017 00:39:21,327 --> 00:39:22,562 EVEN A PEER-REVIEWED JOURNAL 1018 00:39:22,562 --> 00:39:24,330 THAT THE SCIENCE PUBLISHED THERE 1019 00:39:24,330 --> 00:39:26,800 IS TRUE. WHEN I WAS A MEDICAL 1020 00:39:26,800 --> 00:39:29,903 STUDENT ONE OF MY FAVORITE 1021 00:39:29,903 --> 00:39:31,304 PROFESSORS WOULD OFTEN SAY THAT 1022 00:39:31,304 --> 00:39:32,906 WELL, HALF OF WHAT YOU'RE 1023 00:39:32,906 --> 00:39:36,443 LEARNING IN MEDICAL SCHOOL IS 1024 00:39:36,443 --> 00:39:41,581 FALSE AND I WOULD JUST WONDER AT 1025 00:39:41,581 --> 00:39:43,516 THIS BECAUSE YOU'RE LEARNING THE 1026 00:39:43,516 --> 00:39:46,052 KEYS TO HEALTH AND I SAID WHICH 1027 00:39:46,052 --> 00:39:48,421 HALF AND HE WOULD FOLLOW UP 1028 00:39:48,421 --> 00:39:50,123 WITH "I DON'T KNOW". SCIENCE 1029 00:39:50,123 --> 00:39:51,558 THE DIFFICULT. AND IT'S NORMAL 1030 00:39:51,558 --> 00:39:53,860 FOR SCIENTIFIC PROCESSES TO 1031 00:39:53,860 --> 00:39:56,496 END -- SCIENCE TO END UP WITH 1032 00:39:56,496 --> 00:39:58,798 RESULTS THAT TURN OUT IN 1033 00:39:58,798 --> 00:40:02,535 RETROSPECT TO BE FALSE. THE KEY 1034 00:40:02,535 --> 00:40:03,536 TO SCIENTIFIC ADVANCE THEN ISN'T 1035 00:40:03,536 --> 00:40:06,039 JUST PUBLICATION AND RESULTS BUT 1036 00:40:06,039 --> 00:40:09,109 ALSO REPLICATION OF THESE 1037 00:40:09,109 --> 00:40:09,943 RESULTS WHERE SYSTEMATIC 1038 00:40:09,943 --> 00:40:13,246 REPLICATION OF, WITH HIGH 1039 00:40:13,246 --> 00:40:15,415 QUALITY SCIENCE IS SEEN AS THE 1040 00:40:15,415 --> 00:40:17,750 ARBITER FOR WHAT'S TRUE OR FALSE 1041 00:40:17,750 --> 00:40:20,420 IN SCIENCE RATHER THAN 1042 00:40:20,420 --> 00:40:22,322 INFLUENCE, RATHER THAN 1043 00:40:22,322 --> 00:40:24,324 AUTHORITY, IT'S REPLICATION 1044 00:40:24,324 --> 00:40:25,859 THAT'S THE KEY IDEA IN FIELD 1045 00:40:25,859 --> 00:40:27,994 AFTER FIELD AFTER FIELD WE'VE 1046 00:40:27,994 --> 00:40:31,931 SEEN PSYCHOLOGY, WE'VE SEEN A 1047 00:40:31,931 --> 00:40:35,735 CRISIS IN REPLICATION THAT 1048 00:40:35,735 --> 00:40:37,103 UNDERMINES THE CONFIDENCE THAT 1049 00:40:37,103 --> 00:40:40,306 THE PEOPLE HAVE IN SCIENCE. 1050 00:40:40,306 --> 00:40:44,410 NEXT SLIDE, PLEASE. I THINK TO 1051 00:40:44,410 --> 00:40:47,113 ME, WHEN I LOOK AT SOME OF THE 1052 00:40:47,113 --> 00:40:50,783 SCANDALS THAT HAVE HAPPENED IN 1053 00:40:50,783 --> 00:40:53,353 NEUROSCIENCE, IN MANY, MANY 1054 00:40:53,353 --> 00:40:57,690 OTHER FIELDS, WHAT YOU SEE IS 1055 00:40:57,690 --> 00:41:04,264 LEADERS IN THE FIELD MY MIRED IN 1056 00:41:04,264 --> 00:41:06,766 SCANDALS INVOLVING FALSIFICATION 1057 00:41:06,766 --> 00:41:07,267 RESULTS. 1058 00:41:07,267 --> 00:41:09,702 LARGE NUMBERS OF SCIENTIFIC 1059 00:41:09,702 --> 00:41:10,770 RESULTS THAT IN RETROSPECT TURN 1060 00:41:10,770 --> 00:41:14,774 OUT TO BE FALSE WHEN REPLICATED. 1061 00:41:14,774 --> 00:41:16,309 THOSE SCANDALS I VIEW THEM, IF 1062 00:41:16,309 --> 00:41:17,477 YOU THINK ABOUT THEM AS 1063 00:41:17,477 --> 00:41:18,778 INDIVIDUAL MORAL FAILURES I 1064 00:41:18,778 --> 00:41:20,146 THINK YOU'RE GOING TO MAKE A 1065 00:41:20,146 --> 00:41:22,615 MISTAKE. THE WAY TO VIEW THEM 1066 00:41:22,615 --> 00:41:24,717 IS THAT THEY'RE A SYSTEMATIC 1067 00:41:24,717 --> 00:41:28,588 RESULT OF THE INCENTIVES THAT 1068 00:41:28,588 --> 00:41:29,622 SCIENTISTS HAVE IN FIELD AFTER 1069 00:41:29,622 --> 00:41:31,457 FIELD. THE KEY INVENTIVE I WANT 1070 00:41:31,457 --> 00:41:34,260 TO FOCUS ON IS THIS IDEA OF 1071 00:41:34,260 --> 00:41:36,362 PUBLISH OR PERISH. 1072 00:41:36,362 --> 00:41:37,964 SCIENTISTS ADVANCE THEIR CAREERS 1073 00:41:37,964 --> 00:41:40,133 BY PUBLISHING PAPERS, OFTEN 1074 00:41:40,133 --> 00:41:41,668 PAPERS WITH, YOU KNOW, THIS 1075 00:41:41,668 --> 00:41:44,370 CONCEPT OF MINIMAL PUBLISHABLE 1076 00:41:44,370 --> 00:41:46,306 UNIT. YOU HAVE THESE SCIENTIFIC 1077 00:41:46,306 --> 00:41:49,809 RESULTS THAT ARE BOTH 1078 00:41:49,809 --> 00:41:52,312 SIMULTANEOUSLY ONLY INCREMENTAL 1079 00:41:52,312 --> 00:41:53,079 ADVANCES BUT THAT DON'T 1080 00:41:53,079 --> 00:41:54,614 NECESSARILY ATTRACT THE 1081 00:41:54,614 --> 00:41:56,349 ATTENTION OF OTHER SCIENTISTS 1082 00:41:56,349 --> 00:41:57,550 AND YET ADVANCE SCIENTIFIC 1083 00:41:57,550 --> 00:42:00,220 CAREERS BECAUSE YOU GET TO GET 1084 00:42:00,220 --> 00:42:02,722 THEM PUBLISHED IN PEER-REVIEWED 1085 00:42:02,722 --> 00:42:04,991 JOURNALS. THE PROBLEM WITH THIS 1086 00:42:04,991 --> 00:42:08,795 INCENTIVE IS THAT IT FOCUSES ON 1087 00:42:08,795 --> 00:42:10,330 ADVANCING SCIENTIFIC CAREERS 1088 00:42:10,330 --> 00:42:12,298 RATHER THAN ESTABLISHING WHAT'S 1089 00:42:12,298 --> 00:42:14,267 TRUE IN SCIENCE. I HAVE SPOKEN 1090 00:42:14,267 --> 00:42:16,302 WITH MANY DRUG DEVELOPERS WHO 1091 00:42:16,302 --> 00:42:17,770 TELL ME THAT THEY CAN'T TRUST 1092 00:42:17,770 --> 00:42:19,973 THE PUBLISHED BIOMEDICAL 1093 00:42:19,973 --> 00:42:21,341 LITERATURE AND THAT BEFORE THEY 1094 00:42:21,341 --> 00:42:22,175 MAKE MILLIONS AND MILLIONS OF 1095 00:42:22,175 --> 00:42:24,811 DOLLARS IN INVESTMENTS IN 1096 00:42:24,811 --> 00:42:27,313 LARGE-SCALE CLINICAL STUDIES 1097 00:42:27,313 --> 00:42:30,416 THEY WILL COMMISSION THEIR OWN 1098 00:42:30,416 --> 00:42:31,484 PRIVATE REPLICATION EFFORT IN 1099 00:42:31,484 --> 00:42:34,420 ORDER TO CHECK WHETHER THE 1100 00:42:34,420 --> 00:42:36,089 SCIENTIFIC RESULTS ON WHICH 1101 00:42:36,089 --> 00:42:37,991 THEY'RE BASING THEIR FINDINGS 1102 00:42:37,991 --> 00:42:40,426 ARE TRUE. THIS IS A MAJOR 1103 00:42:40,426 --> 00:42:44,030 PROBLEM NOT JUST IN NEUROSCIENCE 1104 00:42:44,030 --> 00:42:46,399 BUT IN BASICALLY EVERY AREA OF 1105 00:42:46,399 --> 00:42:48,334 BIOMEDICAL SCIENCES. NEXT 1106 00:42:48,334 --> 00:42:52,372 SLIDE, PLEASE. SO WHAT IS THE 1107 00:42:52,372 --> 00:42:53,873 SOLUTION? THE SOLUTION IS THAT 1108 00:42:53,873 --> 00:42:56,342 WE HAVE TO CHANGE THE CULTURE OF 1109 00:42:56,342 --> 00:43:00,146 SCIENCE. SO THAT REPLICATION IS 1110 00:43:00,146 --> 00:43:01,481 REWARDED. THE WAY THAT I INTEND 1111 00:43:01,481 --> 00:43:02,782 TO DO THIS WITHIN THE CONTEXT OF 1112 00:43:02,782 --> 00:43:06,386 THE NIH IS WITH A THREEFOLD 1113 00:43:06,386 --> 00:43:09,088 STRATEGY. FIRST, WE HAVE TO 1114 00:43:09,088 --> 00:43:11,691 FUND REPLICATION. WE AT THE NIH 1115 00:43:11,691 --> 00:43:16,062 PRIDE OURSELVES APPROPRIATELY ON 1116 00:43:16,062 --> 00:43:17,630 BREAKTHROUGHS, ON ADVANCES, YOU 1117 00:43:17,630 --> 00:43:19,132 KNOW, I'VE ALREADY JUST SITTING 1118 00:43:19,132 --> 00:43:20,133 IN ON THE LAST FEW MINUTES OF 1119 00:43:20,133 --> 00:43:23,836 THIS COUNCIL I'VE BEEN SO 1120 00:43:23,836 --> 00:43:25,872 IMPRESSED BY SOME OF THE AMAZING 1121 00:43:25,872 --> 00:43:27,240 SCIENCE THAT HAS BEEN DONE TO 1122 00:43:27,240 --> 00:43:33,046 ADVANCE OUR KNOWLEDGE IN 1123 00:43:33,046 --> 00:43:35,481 NEUROSCIENCE. BUT WE DON'T TEND 1124 00:43:35,481 --> 00:43:38,251 TO REWARD SCIENTISTS WHO DO 1125 00:43:38,251 --> 00:43:40,119 REPLICATION WORK. YOU CAN'T GET 1126 00:43:40,119 --> 00:43:43,423 FUNDING FOR IT. YOU, SO, WHAT I 1127 00:43:43,423 --> 00:43:46,426 WANT TO DO IS I WANT THE NIH, 1128 00:43:46,426 --> 00:43:50,563 EVERY PART OF THE NIH TO SUPPORT 1129 00:43:50,563 --> 00:43:52,031 REPLICATION WORK. I WANT THE 1130 00:43:52,031 --> 00:43:53,800 SCIENTIFIC COMMUNITY TO TELL US 1131 00:43:53,800 --> 00:43:57,370 WHAT ARE THE KEY RESULTS THAT 1132 00:43:57,370 --> 00:43:58,771 NEED REPLICATION IN EVERY SINGLE 1133 00:43:58,771 --> 00:44:00,640 FIELD THE RATE LIMITING STEPS IF 1134 00:44:00,640 --> 00:44:02,875 WE NEED TO KNOW IS TRUE, THESE 1135 00:44:02,875 --> 00:44:04,110 IDEAS ARE THOUSAND THAT WE CAN 1136 00:44:04,110 --> 00:44:08,715 HAVE ADVANCES, FURTHER ADVANCES, 1137 00:44:08,715 --> 00:44:09,716 WE SHOULD REWARD SCIENTIFIC 1138 00:44:09,716 --> 00:44:10,817 REPLICATION WITH THE KIND OF 1139 00:44:10,817 --> 00:44:14,387 SUPPORT THAT WE GIVE TO 1140 00:44:14,387 --> 00:44:16,689 INNOVATIVE SCIENCE. OF COURSE, 1141 00:44:16,689 --> 00:44:18,658 REPLICATION ITSELF IS INNOVATIVE 1142 00:44:18,658 --> 00:44:20,259 BECAUSE AN IDEA THAT ISN'T 1143 00:44:20,259 --> 00:44:24,530 REPLICATED CAN'T BE SEEN AS 1144 00:44:24,530 --> 00:44:25,565 TRUE. INDEPENDENT RESEARCH 1145 00:44:25,565 --> 00:44:27,767 TEAMS NEED TO HAVE THE RESOURCES 1146 00:44:27,767 --> 00:44:28,434 AND THE CAPACITY TO CHECK 1147 00:44:28,434 --> 00:44:30,603 WHETHER THE RESULTS ARE TRUE, 1148 00:44:30,603 --> 00:44:35,742 THE KEY RESULTS IN FIELDS ARE 1149 00:44:35,742 --> 00:44:36,909 REPLICABLE. SECOND THERE NEEDS 1150 00:44:36,909 --> 00:44:38,778 TO BE A SPACE IN THE SCIENTIFIC 1151 00:44:38,778 --> 00:44:39,879 LITERATURE WHERE SCIENTIST WHO 1152 00:44:39,879 --> 00:44:42,148 IS DO REPLICATION WORK CAN 1153 00:44:42,148 --> 00:44:45,218 PUBLISH THEIR WORK. OF COURSE 1154 00:44:45,218 --> 00:44:49,122 THE SCIENTIFIC JOURNALS PUBLISH 1155 00:44:49,122 --> 00:44:49,756 META-ANALYSIS, THAT'S GOOD, BUT 1156 00:44:49,756 --> 00:44:52,859 A LOT OF REPLICATION WORK SITS 1157 00:44:52,859 --> 00:44:54,961 IN PRIVATE DRAWERS OF SCIENTISTS 1158 00:44:54,961 --> 00:44:58,197 BECAUSE THEY CAN'T GET THAT WORK 1159 00:44:58,197 --> 00:45:01,067 PUBLISHED. IT'S OFTEN SEEN AS 1160 00:45:01,067 --> 00:45:01,701 DERIVATIVE WHERE IN FACT IT'S 1161 00:45:01,701 --> 00:45:03,536 CENTRAL TO THE ENDEAVOR. I'D 1162 00:45:03,536 --> 00:45:10,042 LIKE TO HAVE THE NIH HAVE A 1163 00:45:10,042 --> 00:45:17,417 PLACE WHERE SCIENTIST WHO IS DO 1164 00:45:17,417 --> 00:45:19,752 REPLICATION WORK WHERE THEY CAN 1165 00:45:19,752 --> 00:45:20,787 PUBLISH THESE RESULTS. 1166 00:45:20,787 --> 00:45:22,555 AND IT'S EASY SEARCHABLE BY THE 1167 00:45:22,555 --> 00:45:23,956 COMMUNITY SO THEY CAN UNDERSTAND 1168 00:45:23,956 --> 00:45:28,161 WHAT RESULTS ARE RELIABLE, WHICH 1169 00:45:28,161 --> 00:45:30,196 RESULTS NEED TO HAVE INDEPENDENT 1170 00:45:30,196 --> 00:45:31,130 REPLICATION. THIRD AND PROBABLY 1171 00:45:31,130 --> 00:45:31,831 THIS IS THE MOST IMPORTANT PART 1172 00:45:31,831 --> 00:45:37,270 OF THIS AGENDA FOR REWARDING 1173 00:45:37,270 --> 00:45:38,237 REPLICATION RIGHT NOW SCIENTISTS 1174 00:45:38,237 --> 00:45:41,374 VIEW THE ACT OF BEING APPROACHED 1175 00:45:41,374 --> 00:45:44,076 FOR REPLICATION, OF THEIR IDEAS 1176 00:45:44,076 --> 00:45:46,446 BEING SUGGEST TO REPLICATION AS 1177 00:45:46,446 --> 00:45:48,481 A THREAT WHERE IN FACT IT'S A 1178 00:45:48,481 --> 00:45:52,452 GREAT HONOR IF YOUR IDEAS ARE 1179 00:45:52,452 --> 00:45:54,787 SOMETHING OTHER SCIENTISTS WANT 1180 00:45:54,787 --> 00:45:55,421 TO CHECK THAT MEANS YOUR IDEAS 1181 00:45:55,421 --> 00:45:56,889 ARE REALLY IMPORTANT. 1182 00:45:56,889 --> 00:45:57,523 SCIENTISTS SHOULD BE REWARDED 1183 00:45:57,523 --> 00:45:59,792 JUST FOR THAT HAPPENING. 1184 00:45:59,792 --> 00:46:01,727 SCIENTISTS WHO ENGAGE IN SOCIAL 1185 00:46:01,727 --> 00:46:04,630 ACTIVITIES LIKE SHARING DATA, 1186 00:46:04,630 --> 00:46:06,632 THEY'RE NOT PART OF THE 1187 00:46:06,632 --> 00:46:09,202 SCIENTIFIC REWARD SYSTEM. WE 1188 00:46:09,202 --> 00:46:10,470 REWARD SCIENTISTS BASED ON HOW 1189 00:46:10,470 --> 00:46:12,205 MANY PUBLICATIONS THEY HAVE AND 1190 00:46:12,205 --> 00:46:13,739 HOW INFLUENTIAL THEIR 1191 00:46:13,739 --> 00:46:14,774 PUBLICATIONS ARE. THAT'S WHAT 1192 00:46:14,774 --> 00:46:16,476 CITATION COUNTS ARE AND OF 1193 00:46:16,476 --> 00:46:18,744 COURSE JOURNAL COUNTS. BUT 1194 00:46:18,744 --> 00:46:22,482 THAT'S TOO NARROW A BASIS FOR 1195 00:46:22,482 --> 00:46:25,585 DECIDE WHETHER SCIENTISTS ARE 1196 00:46:25,585 --> 00:46:26,118 PRODUCTIVE. 1197 00:46:26,118 --> 00:46:28,254 WE NEED TO MEASURE AND REWARD 1198 00:46:28,254 --> 00:46:31,724 THOSE WHO PROVIDE DATA OPENLY. 1199 00:46:31,724 --> 00:46:34,527 WHO ACT IN PROSOCIAL WAYS. IF 1200 00:46:34,527 --> 00:46:37,897 YOU DO THIS, YOU CAN HAVE A 1201 00:46:37,897 --> 00:46:38,798 CULTURAL CHANGE IN SCIENCE. SO 1202 00:46:38,798 --> 00:46:40,600 THAT REPLICATION IS REWARDED AND 1203 00:46:40,600 --> 00:46:42,468 THE INCENTIVES TO COMMIT 1204 00:46:42,468 --> 00:46:44,770 SCIENTIFIC FRAUD GO AWAY. IF 1205 00:46:44,770 --> 00:46:46,405 YOU PUBLISH A SCIENTIFIC PAPER 1206 00:46:46,405 --> 00:46:50,576 IN A TOP JOURNAL WITH FRAUDULENT 1207 00:46:50,576 --> 00:46:53,479 RESULTS YOU DON'T BE REWARDED 1208 00:46:53,479 --> 00:46:55,781 BECAUSE THAT RESULT WON'T BE 1209 00:46:55,781 --> 00:46:57,049 REPLICATED IF WE REWARD 1210 00:46:57,049 --> 00:46:59,151 REPLICATION WE ADDRESS THE LACK 1211 00:46:59,151 --> 00:47:01,020 OF TRUST THAT THE PUBLIC WILL 1212 00:47:01,020 --> 00:47:03,189 HAVE EVEN SCIENTISTS HAVE IN 1213 00:47:03,189 --> 00:47:06,759 THESE PUBLIC SCIENTIFIC RESULTS. 1214 00:47:06,759 --> 00:47:12,498 NEXT SLIDE, PLEASE. THE THIRD 1215 00:47:12,498 --> 00:47:15,902 ITEM WE NEED IS TO MAKE BIG 1216 00:47:15,902 --> 00:47:16,502 ADVANCES. THIS IS SOMETHING 1217 00:47:16,502 --> 00:47:17,537 WE'VE ALREADY BEEN DOING AND 1218 00:47:17,537 --> 00:47:19,305 IT'S ALWAYS POSSIBLE TO DO 1219 00:47:19,305 --> 00:47:20,673 BETTER. IN RESEARCH PAPER THAT 1220 00:47:20,673 --> 00:47:22,074 I PUBLISHED JUST BEFORE THE 1221 00:47:22,074 --> 00:47:24,510 PANDEMIC ANALYZING THE NIH 1222 00:47:24,510 --> 00:47:25,645 PORTFOLIO, WHAT I FOUND WAS THAT 1223 00:47:25,645 --> 00:47:29,382 IN THE 1980S, THE NIH WAS 1224 00:47:29,382 --> 00:47:31,751 FUNDING SCIENTISTS TO PUBLISH 1225 00:47:31,751 --> 00:47:33,019 PAPERS THAT WERE VERY, VERY 1226 00:47:33,019 --> 00:47:34,587 CLOSE TO THE SCIENTIFIC 1227 00:47:34,587 --> 00:47:35,454 FRONTIER, OFTEN IDEAS THAT WERE 1228 00:47:35,454 --> 00:47:39,625 ONE OR TWO YEARS OLD THE NIH 1229 00:47:39,625 --> 00:47:40,560 FUNDED SCIENTISTS FOR PUBLISHING 1230 00:47:40,560 --> 00:47:45,464 IN THE 2000 TEENS IT ACTUALLY 1231 00:47:45,464 --> 00:47:47,300 REGRESDZ. THE NIH FUNDED 1232 00:47:47,300 --> 00:47:48,968 SCIENTISTS WERE PUBLISHING 1233 00:47:48,968 --> 00:47:50,536 PAPERS THAT WERE RELYING ON 1234 00:47:50,536 --> 00:47:52,605 IDEAS THAT WERE 7-8 YEARS OLD 1235 00:47:52,605 --> 00:47:58,578 THE SCIENTIFIC LITERATURE HAS 1236 00:47:58,578 --> 00:48:01,914 BECOME MUCH MORE FOCUSED ON 1237 00:48:01,914 --> 00:48:02,782 INCREMENTAL ADVANCES AT LEAST IN 1238 00:48:02,782 --> 00:48:05,084 THE NIH PORTFOLIO. I WANT TO 1239 00:48:05,084 --> 00:48:06,586 CONTRAST THIS FOR INSTANCE WITH 1240 00:48:06,586 --> 00:48:09,555 SILICON VALLEY WHERE, YOU KNOW, 1241 00:48:09,555 --> 00:48:12,792 IF YOU HAVE A PORTFOLIO OF 1242 00:48:12,792 --> 00:48:14,760 INVESTMENTS AND, YOU KNOW, 40 OF 1243 00:48:14,760 --> 00:48:17,296 THOSE INVESTMENTS TURN OUT TO BE 1244 00:48:17,296 --> 00:48:18,798 DUDS BUT, YOU KNOW, FIVE OF THEM 1245 00:48:18,798 --> 00:48:21,400 TURN OUT TO BE, YOU KNOW, 1246 00:48:21,400 --> 00:48:24,070 GOOGLE, ACTUALLY, EVEN JUST ONE 1247 00:48:24,070 --> 00:48:25,204 TURNS OUT TO BE GOING IT WILL 1248 00:48:25,204 --> 00:48:28,541 PORTFOLIO AS A WHOLE IS A 1249 00:48:28,541 --> 00:48:30,209 SUCCESS. FAILURE IS PUNISHED 1250 00:48:30,209 --> 00:48:32,111 TOO HARSHLY IN SCIENCE IF YOU 1251 00:48:32,111 --> 00:48:33,646 DON'T HAVE A SCIENTIFIC RESULT 1252 00:48:33,646 --> 00:48:35,581 EARLY YOU CAN'T ADVANCE TO YOUR 1253 00:48:35,581 --> 00:48:39,719 NEXT POSTDOC, YOU CAN'T ADVANCE 1254 00:48:39,719 --> 00:48:40,620 TO, EVEN IF YOU'RE VERY BRIGHT 1255 00:48:40,620 --> 00:48:43,522 AND YOU HAVE LOTS AND LOTS OF 1256 00:48:43,522 --> 00:48:46,993 GREAT IDEAS, ONE FAILURE CAN 1257 00:48:46,993 --> 00:48:49,128 LEAD TO ESSENTIALLY HAVING TO 1258 00:48:49,128 --> 00:48:53,065 LEAVE THE SORT OF TENURE TRACK. 1259 00:48:53,065 --> 00:48:55,368 THIS KIND OF PUNISHMENT OF 1260 00:48:55,368 --> 00:48:56,636 FAILURE DISCOURAGES THE TAKING 1261 00:48:56,636 --> 00:48:57,970 THE KINDS OF RISKS THAT MAKE, 1262 00:48:57,970 --> 00:49:00,439 THAT LEAD TO BIG ADVANCES IN 1263 00:49:00,439 --> 00:49:02,008 SCIENCE. AND IT'S AGAIN A 1264 00:49:02,008 --> 00:49:03,509 CULTURE SHIFT, IT'S GOING TO 1265 00:49:03,509 --> 00:49:05,945 TAKE A LOT OF THINKING ABOUT HOW 1266 00:49:05,945 --> 00:49:08,247 TO MAKE THIS HAPPEN, OF COURSE, 1267 00:49:08,247 --> 00:49:10,583 ARPA H IS A STEP IN THAT 1268 00:49:10,583 --> 00:49:13,586 DIRECTION. TO CREATE PORTFOLIOS 1269 00:49:13,586 --> 00:49:17,923 WHERE THERE ARE THESE LIKE BIG 1270 00:49:17,923 --> 00:49:18,824 ADVANCES THAT WILL HOPEFULLY 1271 00:49:18,824 --> 00:49:20,459 COME OUT OF THOSE KINDS OF 1272 00:49:20,459 --> 00:49:22,495 IDEAS. ONE CONCRETE WAY TO 1273 00:49:22,495 --> 00:49:25,064 THINK ABOUT THIS IS THAT IF 1274 00:49:25,064 --> 00:49:26,298 EVERY SINGLE ASPECT AND PROJECT 1275 00:49:26,298 --> 00:49:28,167 IN YOUR, IN THE SCIENTIFIC 1276 00:49:28,167 --> 00:49:30,603 PORTFOLIO, THE NIH IS SEEN AS A 1277 00:49:30,603 --> 00:49:32,571 SUCCESS THEN WE HAVEN'T TAKEN 1278 00:49:32,571 --> 00:49:33,773 BIG ENOUGH RISKS IT NEEDS TO BE 1279 00:49:33,773 --> 00:49:35,307 THE CASE THAT THERE ARE 1280 00:49:35,307 --> 00:49:37,276 SCIENTIFIC PROJECTS THAT WE 1281 00:49:37,276 --> 00:49:38,310 UNDERTAKE THAT WE DON'T KNOW IF 1282 00:49:38,310 --> 00:49:40,413 THEY'RE GOING TO SUCCEED. IT'S 1283 00:49:40,413 --> 00:49:41,981 THE ONLY REAL WAY THAT SCIENCE 1284 00:49:41,981 --> 00:49:43,482 WILL ADVANCE AND SO THAT 1285 00:49:43,482 --> 00:49:44,383 PORTFOLIO AS A WHOLE SHOULD 1286 00:49:44,383 --> 00:49:46,619 SUCCEED IN MAKING ADVANCES EVEN 1287 00:49:46,619 --> 00:49:48,754 IF SOME PARTS OF THE PORTFOLIO 1288 00:49:48,754 --> 00:49:50,756 ARE NOT WORKING THE WAY WE 1289 00:49:50,756 --> 00:49:56,662 THOUGHT. NEXT SLIDE, PLEASE. 1290 00:49:56,662 --> 00:49:58,164 FOURTH, WE HAVE TO MAINTAIN 1291 00:49:58,164 --> 00:49:59,699 SAFETY AND TRANSPARENCY. 1292 00:49:59,699 --> 00:50:01,834 RESEARCH SHOULD BE AT THE 1293 00:50:01,834 --> 00:50:04,136 HIGHEST ETHICAL STANDARDS AND NO 1294 00:50:04,136 --> 00:50:05,638 ENDANGER POPULATIONS. THIS IS 1295 00:50:05,638 --> 00:50:08,607 NOT AN NINDS THING BUT I THINK 1296 00:50:08,607 --> 00:50:10,609 ALL OF SCIENCE NOW SUFFERS FROM 1297 00:50:10,609 --> 00:50:15,614 THE PANDEMIC. THE, IT'S QUITE 1298 00:50:15,614 --> 00:50:17,883 POSSIBLE THAT THE SCIENTIFIC 1299 00:50:17,883 --> 00:50:19,719 WORK ITSELF THAT LED TO THE 1300 00:50:19,719 --> 00:50:20,853 PANDEMIC. CERTAINLY MUCH OF THE 1301 00:50:20,853 --> 00:50:25,391 WORLD POPULATION NOW BELIEVES 1302 00:50:25,391 --> 00:50:26,425 THIS AND WHETHER YOU BELIEVE IT 1303 00:50:26,425 --> 00:50:30,696 OR NOT, WHAT IS TRUE IS THAT 1304 00:50:30,696 --> 00:50:32,531 SCIENTISTS HAVE TAKEN RISKS THAT 1305 00:50:32,531 --> 00:50:35,735 DO ENDANGER HUMAN POPULATIONS. 1306 00:50:35,735 --> 00:50:42,341 CUTTING CORNERS ON ETHICAL, ON 1307 00:50:42,341 --> 00:50:45,244 ETHICAL STANDARDS, PROTECTING 1308 00:50:45,244 --> 00:50:46,746 INFORMED CONSENT, FAILING TO 1309 00:50:46,746 --> 00:50:48,748 PROTECT INFORMED CONSENT HAVE 1310 00:50:48,748 --> 00:50:50,783 LED TO THE PLACE WE'RE AT SO I 1311 00:50:50,783 --> 00:50:54,086 WANT TO MAKE SURE THAT THE NIH 1312 00:50:54,086 --> 00:50:56,055 MAINTAINS SAFETY IN OUR WORK. I 1313 00:50:56,055 --> 00:50:57,590 THINK THE NINDS IS ALREADY QUITE 1314 00:50:57,590 --> 00:50:59,525 GOOD AT THIS BUT THIS IS PART OF 1315 00:50:59,525 --> 00:51:01,727 THE SET OF THINGS I WANT THE NIH 1316 00:51:01,727 --> 00:51:04,296 TO FOCUS ON IN EVERY PART OF 1317 00:51:04,296 --> 00:51:06,532 THIS PORTFOLIO. NEXT SLIDE, 1318 00:51:06,532 --> 00:51:09,835 PLEASE. I THINK THE LAST ONE IN 1319 00:51:09,835 --> 00:51:12,171 MY VISION. FINALLY I WANT TO 1320 00:51:12,171 --> 00:51:13,439 ENCOURAGE ACADEMIC FREEDOM. A 1321 00:51:13,439 --> 00:51:16,075 LOT OF WHAT I THINK IS THE 1322 00:51:16,075 --> 00:51:17,109 PROBLEM IN SCIENCE HAS BEEN THAT 1323 00:51:17,109 --> 00:51:20,312 WE HAVE NOT ALLOWED SCIENTIFIC 1324 00:51:20,312 --> 00:51:21,480 DISSENT TO HAPPEN. CERTAINLY 1325 00:51:21,480 --> 00:51:23,282 DURING THE PANDEMIC I FACED THIS 1326 00:51:23,282 --> 00:51:24,450 MYSELF BUT I DON'T THINK I WAS 1327 00:51:24,450 --> 00:51:28,621 THE ONLY ONE. THE IDEA THAT 1328 00:51:28,621 --> 00:51:29,655 SCIENTISTS SHOULD ALWAYS SPEAK 1329 00:51:29,655 --> 00:51:32,158 WITH ONE VOICE IS A TREMENDOUS 1330 00:51:32,158 --> 00:51:34,627 MISTAKE. OUR SCIENTIFIC 1331 00:51:34,627 --> 00:51:35,928 STRENGTH COMES FROM THE 1332 00:51:35,928 --> 00:51:37,196 POSSIBILITY THAT WE ACCEPT THAT 1333 00:51:37,196 --> 00:51:40,633 WE MIGHT BE WRONG AND IT'S BY 1334 00:51:40,633 --> 00:51:43,269 ALLOWING PEOPLE TO SPEAK THAT 1335 00:51:43,269 --> 00:51:44,670 WE, TO SPEAK THEIR MINDS, TO 1336 00:51:44,670 --> 00:51:46,005 TEST THEIR IDEAS OUT, THAT WE 1337 00:51:46,005 --> 00:51:48,440 MAKE ADVANCES IN SCIENCE. SO 1338 00:51:48,440 --> 00:51:50,776 THIS IS, THAT'S THE LAST OF MY 1339 00:51:50,776 --> 00:51:52,645 FIVE POINTS FROM MY VISION OF 1340 00:51:52,645 --> 00:51:56,482 THE NIH. NEXT SLIDE, PLEASE. 1341 00:51:56,482 --> 00:51:59,151 IN THE LAST, THE FIRST ONE 1342 00:51:59,151 --> 00:52:00,820 HUNDRED DAYS I TOOK OFFICE ABOUT 1343 00:52:00,820 --> 00:52:02,655 A MONTH AND A HALF AGO, AT THE 1344 00:52:02,655 --> 00:52:04,657 BEGINNING OF APRIL IN A VERY 1345 00:52:04,657 --> 00:52:05,691 TREMENDOUSLY TURBULENT TIME AT 1346 00:52:05,691 --> 00:52:07,359 THE NIH'S HISTORY WHERE THERE 1347 00:52:07,359 --> 00:52:14,767 WAS A MAJOR REDUCTION IN FORCE 1348 00:52:14,767 --> 00:52:18,270 AND IT'S BEEN A TURBULENT ONE 1349 00:52:18,270 --> 00:52:19,839 HUNDRED DAYS SINCE THE CHANGE OF 1350 00:52:19,839 --> 00:52:21,173 THE ADMINISTRATION. I WANT TO 1351 00:52:21,173 --> 00:52:22,641 HIGHLIGHT SOME OF THE SUCCESSES 1352 00:52:22,641 --> 00:52:24,210 THAT I THINK HAVE BEEN 1353 00:52:24,210 --> 00:52:27,813 UNDERPLAYED. NEXT SLIDE, 1354 00:52:27,813 --> 00:52:29,615 PLEASE. IN, SINCE I ARRIVED, 1355 00:52:29,615 --> 00:52:31,884 WE'VE DONE A FEW THINGS I THINK 1356 00:52:31,884 --> 00:52:34,720 ARE GOING TO BE REALLY 1357 00:52:34,720 --> 00:52:36,989 IMPORTANT. FIRST, SECRETARY 1358 00:52:36,989 --> 00:52:38,424 KENNEDY ASKED ME TO LAUNCH A 1359 00:52:38,424 --> 00:52:41,794 STUDY ON THE ETIOLOGY OF AUTISM. 1360 00:52:41,794 --> 00:52:45,030 THE NIH ALREADY HAS A FANTASTIC 1361 00:52:45,030 --> 00:52:49,134 PORTFOLIO OF AUTISM RESEARCH BUT 1362 00:52:49,134 --> 00:52:54,406 IT DOES NOT HAVE THE KIND OF 1363 00:52:54,406 --> 00:52:55,307 COMMIT... INVESTMENTS IN 1364 00:52:55,307 --> 00:52:57,376 UNDERSTANDING THE ETIOLOGY OF 1365 00:52:57,376 --> 00:52:59,712 AUTISM THAT WE KNOW HAVE. WITH 1366 00:52:59,712 --> 00:53:01,680 THIS INITIATIVE WE'RE GOING TO 1367 00:53:01,680 --> 00:53:05,651 HAVE A... CREATE A REAL WORLD 1368 00:53:05,651 --> 00:53:08,754 DATA PLATFORM INVITE RESEARCHERS 1369 00:53:08,754 --> 00:53:10,122 ACROSS THE COUNTRY TO COMPETE 1370 00:53:10,122 --> 00:53:11,290 WITH THEIR IDEAS TO UNDERSTAND 1371 00:53:11,290 --> 00:53:16,128 THE ETIOLOGY OF AUTISM AND ITS 1372 00:53:16,128 --> 00:53:17,596 CO-OCCURRING CONDITIONS. WITH A 1373 00:53:17,596 --> 00:53:20,699 BROAD RANGE OF POSSIBLE 1374 00:53:20,699 --> 00:53:22,101 HYPOTHESES FOR WHAT THE CAUSE 1375 00:53:22,101 --> 00:53:23,535 IS. IF YOU ASK ME AS A 1376 00:53:23,535 --> 00:53:25,404 SCIENTIST DO I KNOW THE CAUSE? 1377 00:53:25,404 --> 00:53:28,741 I DON'T. AND IT'S A PROBLEM 1378 00:53:28,741 --> 00:53:30,776 BECAUSE WITHOUT UNDERSTANDING 1379 00:53:30,776 --> 00:53:32,478 BETTER ETIOLOGY WE CAN'T ADDRESS 1380 00:53:32,478 --> 00:53:36,615 THE PROBLEMS OF SO MANY KIDS. A 1381 00:53:36,615 --> 00:53:38,817 RECENT CDC STUDY ESTIMATE THAT 1382 00:53:38,817 --> 00:53:44,623 HAD ONE IN THIRTY K-ONE KIDS HA 1383 00:53:44,623 --> 00:53:46,392 AUTISM IN THIS COUNTRY AND WE 1384 00:53:46,392 --> 00:53:49,662 DON'T HAVE ANSWERS WITH THESE 1385 00:53:49,662 --> 00:53:54,934 KIDS WITH A RANGE OF A SORT OF 1386 00:53:54,934 --> 00:54:00,105 SYMPTOMS FROM LIKE VERY HIGH 1387 00:54:00,105 --> 00:54:02,708 FUNCTIONING KIDS WHO ARE WELL 1388 00:54:02,708 --> 00:54:04,810 INTEGRATED IN SOCIETY TO 1389 00:54:04,810 --> 00:54:08,047 SEVERELY DISABLED CHILDREN. 1390 00:54:08,047 --> 00:54:10,182 UNDERSTANDING THE ETIOLOGY OF 1391 00:54:10,182 --> 00:54:13,619 THESE DIFFERENT MANIFESTATIONS 1392 00:54:13,619 --> 00:54:14,586 INCLUDING THE BIOMEDICALLY 1393 00:54:14,586 --> 00:54:15,988 CAUSED CO-OCCURRING CONDITIONS I 1394 00:54:15,988 --> 00:54:17,456 THINK IS GOING TO BE VERY 1395 00:54:17,456 --> 00:54:20,559 IMPORTANT. SECOND, WE HAVE 1396 00:54:20,559 --> 00:54:22,294 ADOPTED A NEW POLICY THAT 1397 00:54:22,294 --> 00:54:24,263 ENCOURAGES HUMAN BASED RESEARCH 1398 00:54:24,263 --> 00:54:27,266 TECHNOLOGIES OVER ANIMAL MODELS 1399 00:54:27,266 --> 00:54:29,001 THAT DO NOT REPRESENT 1400 00:54:29,001 --> 00:54:29,768 NECESSARILY KNOWLEDGE THAT CAN 1401 00:54:29,768 --> 00:54:32,137 BE TRANSLATED INTO HUMANS. FROM 1402 00:54:32,137 --> 00:54:35,708 WHAT I UNDERSTAND, IT'S REALLY, 1403 00:54:35,708 --> 00:54:38,410 IT'S POSSIBLE TO CAUSE MICE TO 1404 00:54:38,410 --> 00:54:39,445 HAVE ALZHEIMER'S DISEASE AND 1405 00:54:39,445 --> 00:54:41,113 IT'S ALSO POSSIBLE TO CURE 1406 00:54:41,113 --> 00:54:43,515 ALZHEIMER'S DISEASE IN MICE. 1407 00:54:43,515 --> 00:54:49,188 BUT HOW WELL DO THOSE, THE 1408 00:54:49,188 --> 00:54:50,656 KNOWLEDGE IN HUMANS IS SORT OF 1409 00:54:50,656 --> 00:54:52,391 LESS CLEAR TO ME. BY 1410 00:54:52,391 --> 00:54:54,593 PRIORITIZING HUMAN BASED 1411 00:54:54,593 --> 00:54:57,262 RESEARCH TECHNOLOGIES INCLUDING 1412 00:54:57,262 --> 00:55:00,532 ORGANOIDS, INCLUDING AI 1413 00:55:00,532 --> 00:55:02,768 TECHNOLOGIES, WE CAN FOCUS OUR 1414 00:55:02,768 --> 00:55:04,837 SCIENCE ON THINGS THAT MAKE THE 1415 00:55:04,837 --> 00:55:06,372 JUMP INTO HUMANS AND ADVANCE THE 1416 00:55:06,372 --> 00:55:10,175 HEALTH FOR HUMANS MORE EASILY I 1417 00:55:10,175 --> 00:55:11,877 THINK. THIRD, WE ACCELERATED A 1418 00:55:11,877 --> 00:55:14,613 NEW PUBLIC ACCESS POLICY SO THAT 1419 00:55:14,613 --> 00:55:16,982 THE ADVANCES THAT THE NIH MAKES 1420 00:55:16,982 --> 00:55:21,587 WILL BE MORE EASILY LICENSABLE 1421 00:55:21,587 --> 00:55:25,724 BY COMPANIES AROUND AND... 1422 00:55:25,724 --> 00:55:28,227 AROUND THE WORLD. FOURTH, I 1423 00:55:28,227 --> 00:55:29,928 GUESS THAT WAS SECOND. THAT WAS 1424 00:55:29,928 --> 00:55:31,730 THIRD, NOW FOURTH, I PUT IN A 1425 00:55:31,730 --> 00:55:34,767 POLICY THAT PROMOTES ACADEMIC 1426 00:55:34,767 --> 00:55:36,635 FREEDOM AT THE NIH WHAT I 1427 00:55:36,635 --> 00:55:39,104 LEARNED WHEN I FIRST ARRIVED IS 1428 00:55:39,104 --> 00:55:40,672 THERE WAS ACTUAL OVERSIGHT OVER 1429 00:55:40,672 --> 00:55:42,775 THE PUBLICATION OF RESULTS BY 1430 00:55:42,775 --> 00:55:44,977 SUPERVISORS, SCIENTISTS HAD TO 1431 00:55:44,977 --> 00:55:47,946 DO GET SUPERVISORS TO CLEAR 1432 00:55:47,946 --> 00:55:50,416 SCIENTIFIC PAPERS. I WOULD LIKE 1433 00:55:50,416 --> 00:55:52,751 THE NIH RESEARCHERS, INTRAMURAL 1434 00:55:52,751 --> 00:55:54,553 RESEARCHERS TO ENJOY THE SAME 1435 00:55:54,553 --> 00:55:57,689 ACADEMIC FREEDOM I ENJOYED AT 1436 00:55:57,689 --> 00:55:59,358 STANFORD UNIVERSITY UNTIL 2020. 1437 00:55:59,358 --> 00:56:01,326 SCIENTISTS SHOULD BE ABLE TO 1438 00:56:01,326 --> 00:56:02,761 PUBLISH THEIR RESULTS AS LONG AS 1439 00:56:02,761 --> 00:56:04,496 THE RESULTS ARE SUBJECT TO 1440 00:56:04,496 --> 00:56:07,800 REPLICATION THAT'S HOW WE GET 1441 00:56:07,800 --> 00:56:11,103 SCIENTIFIC TRUTH. THE, WE 1442 00:56:11,103 --> 00:56:12,171 LAUNCHED A NEW PROGRAM TO LOOK 1443 00:56:12,171 --> 00:56:14,773 FOR THE NEXT GENERATION OF FLU 1444 00:56:14,773 --> 00:56:17,776 VACCINES AND POSSIBLY A 1445 00:56:17,776 --> 00:56:19,945 UNIVERSAL FLU VACCINE CALLING IT 1446 00:56:19,945 --> 00:56:21,313 GENERATION GOLD STANDARD. 1447 00:56:21,313 --> 00:56:22,948 FIFTH, WE HAVE A NEW PROGRAM TO 1448 00:56:22,948 --> 00:56:24,450 IMPROVE THE SAFETY AND SECURITY 1449 00:56:24,450 --> 00:56:28,387 OF BIOLOGICAL RESEARCH, THE KIND 1450 00:56:28,387 --> 00:56:30,722 OF GAIN OF FUNCTION WORK, A 1451 00:56:30,722 --> 00:56:33,092 SMALL FRACTION OF THE BIOLOGY WE 1452 00:56:33,092 --> 00:56:36,295 DO BUT POTENTIALLY QUITE 1453 00:56:36,295 --> 00:56:37,596 DANGEROUS HAS THE POTENTIAL TO 1454 00:56:37,596 --> 00:56:40,799 CAUSE A PANDEMIC WILL BE MUCH 1455 00:56:40,799 --> 00:56:43,502 MORE RIGOROUSLY REGULATED. WE 1456 00:56:43,502 --> 00:56:47,639 IMPROVE THE FOREIGN SUBAWARDS, 1457 00:56:47,639 --> 00:56:49,041 THIS HAS BEEN THE SUBJECT OF A 1458 00:56:49,041 --> 00:56:51,810 LOT OF MISUNDERSTANDING. IT WAS 1459 00:56:51,810 --> 00:56:55,013 IMPOSSIBLE FOR THE NIH TO TRACK 1460 00:56:55,013 --> 00:56:58,350 FULLY THE SPENDING ON SUBAWARDS. 1461 00:56:58,350 --> 00:56:59,485 WE WERE UNABLE FOR INSTANCE TO 1462 00:56:59,485 --> 00:57:02,754 GAIN ACCESS TO THE LAB NOTEBOOKS 1463 00:57:02,754 --> 00:57:04,389 OF THE WUHAN LABORATORY FUNDED 1464 00:57:04,389 --> 00:57:06,758 BY THE NIH. WE NOW PUT IN A 1465 00:57:06,758 --> 00:57:09,895 SYSTEM THAT ALLOWS RESEARCHERS 1466 00:57:09,895 --> 00:57:13,165 TO COLLABORATE WITH FOREIGN 1467 00:57:13,165 --> 00:57:20,305 INSTITUTIONS BUT GIVES THE NIH 1468 00:57:20,305 --> 00:57:21,707 MORE OVERSIGHT IN THE RESEARCH 1469 00:57:21,707 --> 00:57:23,275 THAT TAKES PLACE IN THOSE. IT 1470 00:57:23,275 --> 00:57:24,676 WILL ALLOW FOREIGN 1471 00:57:24,676 --> 00:57:25,744 COLLABORATIONS TO HAPPEN WITHIN 1472 00:57:25,744 --> 00:57:28,514 THE NIH BUT IN A MORE SURE WAY. 1473 00:57:28,514 --> 00:57:33,085 AND FINALLY WE'RE UNDERTAKING A 1474 00:57:33,085 --> 00:57:40,893 ROOT CAUSES PROGRAM. THIS IS 1475 00:57:40,893 --> 00:57:43,662 THE WORK OF THE ENTIRETY OF THE 1476 00:57:43,662 --> 00:57:45,063 NIH THAT HAS ALLOWED THIS TO BE 1477 00:57:45,063 --> 00:57:47,499 POSSIBLE. NEXT SLIDE, PLEASE. 1478 00:57:47,499 --> 00:57:50,769 I THINK LAST ONE. 75 YEARS OF 1479 00:57:50,769 --> 00:57:55,374 NEUROSCI 1480 00:57:55,374 --> 00:57:56,041 NEUROSCIENCE, THE NIH HAS PLAYED 1481 00:57:56,041 --> 00:57:57,843 AN IMPORTANT ROLE IN THAT. I'M 1482 00:57:57,843 --> 00:58:00,379 PROUD OF THE NINDS AND ALL THE 1483 00:58:00,379 --> 00:58:00,913 WORK DONE TO ADVANCE OUR 1484 00:58:00,913 --> 00:58:02,114 KNOWLEDGE OF NEUROSCIENCE AND I 1485 00:58:02,114 --> 00:58:06,752 THINK IN COMING YEARS WE'LL 1486 00:58:06,752 --> 00:58:09,988 START TO SEE IT PAY FRUIT IN 1487 00:58:09,988 --> 00:58:12,424 ADVANCING THE HEALTH OF THE 1488 00:58:12,424 --> 00:58:15,327 FOLKS ON ALZHEIMER'S DISEASE, ON 1489 00:58:15,327 --> 00:58:17,095 PARKINSON'S DISEASE, ON STROKES, 1490 00:58:17,095 --> 00:58:22,935 ON A WHOLE HOST OF NEUROLOGICAL 1491 00:58:22,935 --> 00:58:23,235 C 1492 00:58:23,235 --> 00:58:24,203 CONDITIONS, THE KNOWLEDGE THAT 1493 00:58:24,203 --> 00:58:25,304 WE GAINED WILL WORK TO IMPROVE 1494 00:58:25,304 --> 00:58:26,471 THE HEALTH OF THE AMERICAN 1495 00:58:26,471 --> 00:58:28,307 PEOPLE. NEXT SLIDE, I THINK THE 1496 00:58:28,307 --> 00:58:30,142 LAST ONE. LAST ONE. I WANTED 1497 00:58:30,142 --> 00:58:33,111 TO LEAVE PLENTY OF TIME FOR 1498 00:58:33,111 --> 00:58:34,279 QUESTIONS. I HOPE I HAVE. 1499 00:58:34,279 --> 00:58:35,347 >> WALTER: THAT WAS GREAT, JAY. 1500 00:58:35,347 --> 00:58:39,251 AND, YEAH, A LOT OF THE TOPICS 1501 00:58:39,251 --> 00:58:42,754 CERTAI 1502 00:58:42,754 --> 00:58:44,156 CERTAINLY WE COULD SIT DOWN WITH 1503 00:58:44,156 --> 00:58:46,491 COVER FEE AND GO OVER IN DETAIL. 1504 00:58:46,491 --> 00:58:48,961 WE'VE CERTAINLY BEEN STRUGGLING 1505 00:58:48,961 --> 00:58:50,662 IN TRYING TO HELP IN MANY OF 1506 00:58:50,662 --> 00:58:53,031 THOSE SPACES. BUT I WANTED TO 1507 00:58:53,031 --> 00:58:55,234 GIVE TIME FOR SOME OF THE 1508 00:58:55,234 --> 00:58:58,303 COUNCILMEMBERS TO ASK SOME 1509 00:58:58,303 --> 00:59:00,872 QUESTIONS. I SEE HANK PAULSON 1510 00:59:00,872 --> 00:59:02,774 FROM UNIVERSITY OF MICHIGAN HAD 1511 00:59:02,774 --> 00:59:06,612 HIS HAND UP. HANK WORKS IN 1512 00:59:06,612 --> 00:59:07,212 NEURODEGENERATIVE DISEASES, 1513 00:59:07,212 --> 00:59:08,680 PARTICULARLY TRYING TO GET AT 1514 00:59:08,680 --> 00:59:13,585 THE CLUES THAT COME FROM GENETIC 1515 00:59:13,585 --> 00:59:16,021 CAUSES AND SO HANK. 1516 00:59:16,021 --> 00:59:20,192 >> HANK: THANK YOU, WALTER, 1517 00:59:20,192 --> 00:59:22,761 DR. BAT TA CHARIA. WE HELP WE 1518 00:59:22,761 --> 00:59:25,430 CAN ERADICATE CHRONIC DISEASES. 1519 00:59:25,430 --> 00:59:27,566 AND AS YOU MENTIONED SO MANY 1520 00:59:27,566 --> 00:59:29,701 CHRONIC DISEASES ARE IN THE 1521 00:59:29,701 --> 00:59:31,203 PURVIEW OF NINDS SO WE'LL KEEP 1522 00:59:31,203 --> 00:59:32,437 WORKING ON THAT. I HAVE SO MANY 1523 00:59:32,437 --> 00:59:33,505 QUESTIONS BUT I WILL KEEP IT 1524 00:59:33,505 --> 00:59:35,807 JUST TO A FEW. THE FIRST ONE I 1525 00:59:35,807 --> 00:59:37,142 GOT TWO QUESTIONS I WILL GIVE 1526 00:59:37,142 --> 00:59:39,945 YOU THE FIRST ONE IS 1527 00:59:39,945 --> 00:59:41,613 PRIORITIZING HUMAN BASED, YOU 1528 00:59:41,613 --> 00:59:43,615 KNOW, APPROACHES I THINK THAT IS 1529 00:59:43,615 --> 00:59:45,784 REALLY POWERFUL. ORGANOIDS CAN 1530 00:59:45,784 --> 00:59:46,618 BE REALLY IMPORTANT. I JUST 1531 00:59:46,618 --> 00:59:48,687 WANT TO KNOW HOW THAT IS DONE 1532 00:59:48,687 --> 00:59:49,755 BECAUSE IF YOU THINK ABOUT IT 1533 00:59:49,755 --> 00:59:52,991 LIKE THE ROUNDWORM, THE NEEM 1534 00:59:52,991 --> 00:59:56,995 TOAD LED TO THE DISCOVERY. AND 1535 00:59:56,995 --> 01:00:00,966 OTHERS ABOUT THE PATHWAYS OF 1536 01:00:00,966 --> 01:00:01,633 NEUROPRESENTATIVE DISEASE AND IN 1537 01:00:01,633 --> 01:00:03,869 MICE I KNOW THE AMYLOID IS ONLY 1538 01:00:03,869 --> 01:00:05,904 A SMALL PART OF THE ALZHEIMER'S 1539 01:00:05,904 --> 01:00:06,305 PICTURE. 1540 01:00:06,305 --> 01:00:08,340 BUT IT WAS IN MICE THAT WE SHOW 1541 01:00:08,340 --> 01:00:08,940 THAT HAD ACTUALLY YOU COULD 1542 01:00:08,940 --> 01:00:10,776 VACCINATE AND STOP THE DISEASE 1543 01:00:10,776 --> 01:00:12,277 IN MICE AND NOW WE HAVE GAME 1544 01:00:12,277 --> 01:00:13,945 CHANGING THERAPIES IN HUMANS. 1545 01:00:13,945 --> 01:00:17,015 SO THERE ARE WAYS IN WHICH THESE 1546 01:00:17,015 --> 01:00:19,051 NONHUMAN SYSTEMS ARE STILL VERY 1547 01:00:19,051 --> 01:00:20,352 VALUABLE SO I AM CURIOUS WHEN 1548 01:00:20,352 --> 01:00:22,487 YOU SAY PRIORITIZE, THAT'S 1549 01:00:22,487 --> 01:00:24,956 GREAT, BUT WILL THAT MEAN THAT 1550 01:00:24,956 --> 01:00:27,492 WE WILL ELIMINATE OR MARKEDLY 1551 01:00:27,492 --> 01:00:28,894 REDUCE OR HAVE, YOU KNOW, 1552 01:00:28,894 --> 01:00:29,895 REQUEST FOR APPLICATIONS THAT 1553 01:00:29,895 --> 01:00:32,531 ARE ONLY FOCUSED ON HUMAN BASED 1554 01:00:32,531 --> 01:00:34,266 APPROACHES AND, ET CETERA, WHAT, 1555 01:00:34,266 --> 01:00:38,770 JUST FLESH THAT OUT A LITTLE BIT 1556 01:00:38,770 --> 01:00:39,805 FOR ME 1557 01:00:39,805 --> 01:00:42,374 >> JAYANTA: THIS IS SUBTLE AND 1558 01:00:42,374 --> 01:00:44,409 DIFFERENT IN EVERY FIELD I THINK 1559 01:00:44,409 --> 01:00:46,845 ROUTINELY FOCUSING ON ANIMAL 1560 01:00:46,845 --> 01:00:49,881 MODELS THAT DO NOT TRANSLATE. 1561 01:00:49,881 --> 01:00:52,651 THE WAY YOU ADDRESS THAT IS TO 1562 01:00:52,651 --> 01:00:54,753 ASK RESEARCHERS TO JUSTIFY USE 1563 01:00:54,753 --> 01:00:57,189 OF THOSE ANIMAL MODELS. I'M NOT 1564 01:00:57,189 --> 01:00:58,156 SAYING ERADICATE THEM. I AGREE 1565 01:00:58,156 --> 01:01:00,292 WITH YOU. THE HISTORY OF 1566 01:01:00,292 --> 01:01:02,027 SCIENCE INVOLVES LOTS OF 1567 01:01:02,027 --> 01:01:02,761 UNDERSTANDING THAT WE GAINED 1568 01:01:02,761 --> 01:01:05,831 FROM ANIMAL MODELS BUT AT THE 1569 01:01:05,831 --> 01:01:06,765 SAME TIME, JUST DOING DOING 1570 01:01:06,765 --> 01:01:10,702 THOSE ANIMAL MODELS WHEN THEY 1571 01:01:10,702 --> 01:01:12,170 HAVEN'T RESULTED IN ADVANCES IN 1572 01:01:12,170 --> 01:01:15,107 HUMAN HEALTH, DOESN'T MAKE 1573 01:01:15,107 --> 01:01:15,640 SENSE. 1574 01:01:15,640 --> 01:01:18,043 SO IT'S A CULTURAL SHIFT THAT I 1575 01:01:18,043 --> 01:01:20,011 THINK WE'RE TRYING TO INDUCE IN 1576 01:01:20,011 --> 01:01:21,947 SCIENCE WHERE WE ASK SCIENTIST 1577 01:01:21,947 --> 01:01:24,015 TO SAY, DO THESE ANIMAL MODELS 1578 01:01:24,015 --> 01:01:26,151 ACTUALLY RESULT IN ADVANCES IN 1579 01:01:26,151 --> 01:01:27,386 KNOWLEDGE THAT ADVANCE HUMAN 1580 01:01:27,386 --> 01:01:29,221 HEALTH? SOMETIMES, IF YOU'RE 1581 01:01:29,221 --> 01:01:31,690 TALKING ABOUT BASIC SCIENCE, YOU 1582 01:01:31,690 --> 01:01:34,760 KNOW, YOU MAY HAVE ANIMAL MODELS 1583 01:01:34,760 --> 01:01:37,729 WHERE YOU NEED NEMATODES, ALL OF 1584 01:01:37,729 --> 01:01:40,198 THOSE ARE REALLY GREAT EXAMPLES 1585 01:01:40,198 --> 01:01:42,768 OF WHERE ANIMAL MODELS HAVE 1586 01:01:42,768 --> 01:01:44,136 ADVAN 1587 01:01:44,136 --> 01:01:47,305 ADVANCED BIOLAOGICAL IDEAS BUT 1588 01:01:47,305 --> 01:01:49,841 LOT OF TYPES THEY DON'T 1589 01:01:49,841 --> 01:01:51,510 TRANSLATE AND WE'RE ASKING 1590 01:01:51,510 --> 01:01:53,145 SCIENTIST TO THINK CRITICALLY 1591 01:01:53,145 --> 01:01:54,346 ABOUT THE ANIMAL MODELS. 1592 01:01:54,346 --> 01:01:55,747 THERE ARE THESE NEWER 1593 01:01:55,747 --> 01:01:59,251 TECHNOLOGIES THAT ARE COMING UP. 1594 01:01:59,251 --> 01:02:00,719 NOTHING'S PERFECT. BUT AS THEY 1595 01:02:00,719 --> 01:02:03,021 ARE REALLY GOOD IN MANY, MANY 1596 01:02:03,021 --> 01:02:04,289 CASES. WHAT WE'RE TRYING TO DO 1597 01:02:04,289 --> 01:02:06,992 WITH THIS IS INDUCE A CULTURAL 1598 01:02:06,992 --> 01:02:09,361 SHIFT IN SCIENCE TOWARD HUMAN 1599 01:02:09,361 --> 01:02:12,464 BASED OUTCOMES RATHER THAN JUST, 1600 01:02:12,464 --> 01:02:14,299 YOU KNOW, IF YOU'RE USE -- JUST 1601 01:02:14,299 --> 01:02:15,934 BECAUSE YOU'RE USED TO AN ANIMAL 1602 01:02:15,934 --> 01:02:18,637 HOD DELL DOESN'T MEAN YOU SHOULD 1603 01:02:18,637 --> 01:02:18,904 CONTINUE. 1604 01:02:18,904 --> 01:02:19,638 QUESTION IS WHAT, SCIENCE CAN 1605 01:02:19,638 --> 01:02:28,180 YOU DO THAT WILL TRANSLATE OVER? 1606 01:02:28,180 --> 01:02:29,748 >> HANK: I DO HAVE OTHER 1607 01:02:29,748 --> 01:02:31,416 QUESTIONS BUT I THINK I WILL 1608 01:02:31,416 --> 01:02:32,284 HOLD OFF AND LET OTHER PEOPLE 1609 01:02:32,284 --> 01:02:33,518 ASK QUESTIONS FIRST. 1610 01:02:33,518 --> 01:02:37,289 >> HI, I'M A NEUROLOGIST, STROKE 1611 01:02:37,289 --> 01:02:39,624 NEUROLOGIST HERE IN TEXAS. AND 1612 01:02:39,624 --> 01:02:41,159 WHEN WE TALK ABOUT CHRONIC 1613 01:02:41,159 --> 01:02:43,595 DISEASES OBVIOUSLY STROKE IS A 1614 01:02:43,595 --> 01:02:44,830 MAJOR BURDEN, ALZHEIMER'S IS A 1615 01:02:44,830 --> 01:02:47,799 MAJOR BURDEN AND A LOT OF THIS 1616 01:02:47,799 --> 01:02:50,769 BURDEN CAN BE REDUCED BY 1617 01:02:50,769 --> 01:02:53,071 PREVENTION EFFORTS WHICH I KNOW 1618 01:02:53,071 --> 01:02:54,773 IS ONE OF YOUR MAJOR FOCUSES. 1619 01:02:54,773 --> 01:02:57,909 HOW DO YOU SEE, UP -- THEY 1620 01:02:57,909 --> 01:03:01,213 ESTIMATED UP TO 40% OF 1621 01:03:01,213 --> 01:03:03,148 ALZHEIMER'S CAN BE PREVENTED BY 1622 01:03:03,148 --> 01:03:06,284 REDUCING DIABETES, HYPERTENSION, 1623 01:03:06,284 --> 01:03:08,386 OTHER THINGS THAT DRIVE 1624 01:03:08,386 --> 01:03:09,221 NEURODEGENERATIVE DISEASES BUT 1625 01:03:09,221 --> 01:03:12,023 HOW DO YOU SEE THESE PREVENTION 1626 01:03:12,023 --> 01:03:14,125 EFFORTS ACTUALLY BEING 1627 01:03:14,125 --> 01:03:15,827 ACTIONABLE? WE KNOW WHAT WE'RE 1628 01:03:15,827 --> 01:03:17,128 SUPPOSED TO DO. WE KNOW WHAT WE 1629 01:03:17,128 --> 01:03:19,531 SHOULD BE TREATING. AND YET 1630 01:03:19,531 --> 01:03:22,767 THERE'S, AGAIN, A VERY LARGE GAP 1631 01:03:22,767 --> 01:03:26,771 BETWEEN IMPLEMENTING THAT IN OUR 1632 01:03:26,771 --> 01:03:28,507 POPULATIONS. AND SPECIFICALLY 1633 01:03:28,507 --> 01:03:29,508 POPULATIONS DISPARITY 1634 01:03:29,508 --> 01:03:32,310 POPULATIONS. SO DO YOU HAVE ANY 1635 01:03:32,310 --> 01:03:33,845 IDEAS ABOUT HOW WE CAN MAKE THAT 1636 01:03:33,845 --> 01:03:36,181 GAP? BECAUSE FOR ME, WHO DOES 1637 01:03:36,181 --> 01:03:36,815 TRANSLATIONAL RESEARCH AS WELL 1638 01:03:36,815 --> 01:03:39,117 AS CLINICAL RESEARCH, THAT IS AS 1639 01:03:39,117 --> 01:03:42,754 BIG, IF NOT BIGGER PROBLEM THAN 1640 01:03:42,754 --> 01:03:47,526 TRANSLATING FROM ANIMAL MODELS 1641 01:03:47,526 --> 01:03:49,160 >> JAYANTA: I ALSO WORK IN THIS 1642 01:03:49,160 --> 01:03:50,529 AREA. I FEEL YOUR PAIN. I 1643 01:03:50,529 --> 01:03:52,197 THINK PART OF IT IS THE WAY WE 1644 01:03:52,197 --> 01:03:54,799 THINK ABOUT THIS. IF WE HAVE 1645 01:03:54,799 --> 01:03:56,067 OUR VIEW IS OKAY, WE HAVE THE 1646 01:03:56,067 --> 01:03:58,136 TRUTH AND WE JUST HAVE TO LIKE 1647 01:03:58,136 --> 01:03:58,803 CONVINCE EVERYBODY THAT WE HAVE 1648 01:03:58,803 --> 01:04:02,541 THIS AMAZING TRUTH AND THEN JUST 1649 01:04:02,541 --> 01:04:04,543 LISTEN TO US. IT'S NOT GOING TO 1650 01:04:04,543 --> 01:04:06,745 WORK AND WE ALSO CAN'T COME AT 1651 01:04:06,745 --> 01:04:09,381 IT AS IF WE ARE SITTING ABOVE 1652 01:04:09,381 --> 01:04:11,850 AND SAYING YOU MUST DO THIS OR, 1653 01:04:11,850 --> 01:04:14,252 I MEAN, IT'S, WE HAVE TO BE 1654 01:04:14,252 --> 01:04:16,655 PARTNERS IN THE COMMUNITIES THAT 1655 01:04:16,655 --> 01:04:18,423 ARE AFFECTED BY THESE. PART OF 1656 01:04:18,423 --> 01:04:20,825 THE PROBLEM ALSO LOUISE IS I 1657 01:04:20,825 --> 01:04:22,527 THINK WE THINK WE KNOW THE 1658 01:04:22,527 --> 01:04:24,195 ANSWER WHEN SOMETIMES WE DON'T. 1659 01:04:24,195 --> 01:04:26,765 I WAS LOOKING AT ACTUALLY, I 1660 01:04:26,765 --> 01:04:29,000 JUST GAVE A TALK AT THIS 1661 01:04:29,000 --> 01:04:29,601 NUTRITION MEETING AND I WAS 1662 01:04:29,601 --> 01:04:33,271 LOOKING BACK AT THE HISTORY OF 1663 01:04:33,271 --> 01:04:38,376 RECOMMENDATIONS ABOUT EGGS. 1664 01:04:38,376 --> 01:04:40,812 AND -- EXACTLY. I THINK IF WE 1665 01:04:40,812 --> 01:04:41,913 ARE MORE HUMBLE ABOUT OUR 1666 01:04:41,913 --> 01:04:45,784 SCIENCE WE SAY, OKAY, LET'S WAIT 1667 01:04:45,784 --> 01:04:48,653 UNTIL WE HAVE LOTS OF TEAMS 1668 01:04:48,653 --> 01:04:50,322 REPLICATED IT. WE PARTICIPATE 1669 01:04:50,322 --> 01:04:52,524 AS PARTNERS WITH FOLKS IN THE 1670 01:04:52,524 --> 01:04:54,759 COMMUNITY RATHER THAN AS SITTING 1671 01:04:54,759 --> 01:04:58,229 ABOVE. WE'LL HAVE MUCH BETTER 1672 01:04:58,229 --> 01:04:59,464 LUCK TRANSLATING WHAT WE DO 1673 01:04:59,464 --> 01:05:01,466 ACTUALLY KNOW RELIABLY INTO 1674 01:05:01,466 --> 01:05:02,767 PRACTICE. AND I AGREE WITH YOU. 1675 01:05:02,767 --> 01:05:06,771 I THINK A LOT OF THE BURDEN OF 1676 01:05:06,771 --> 01:05:11,109 DISEASE IN ALZHEIMER'S IS 1677 01:05:11,109 --> 01:05:12,611 ADDRESSABLE. BUT I THINK WE 1678 01:05:12,611 --> 01:05:15,413 JUST DON'T DO IT, WE DON'T KNOW 1679 01:05:15,413 --> 01:05:16,681 HOW TO DO IT RIGHT. 1680 01:05:16,681 --> 01:05:18,016 >> DO YOU HAVE IDEAS ABOUT HOW 1681 01:05:18,016 --> 01:05:22,354 TO DO THAT IMPLEMENTATION 1682 01:05:22,354 --> 01:05:24,556 >> MEAN -- I MEAN WE KNOW THAT 1683 01:05:24,556 --> 01:05:27,192 HAVING A BLOOD PRESSURE OF 1684 01:05:27,192 --> 01:05:29,427 200/100 IS NOT GOOD FOR YOUR 1685 01:05:29,427 --> 01:05:29,661 BRAIN. 1686 01:05:29,661 --> 01:05:31,396 WE CAN DO THESE COMMUNITY THINGS 1687 01:05:31,396 --> 01:05:32,864 BUT WE'RE SEEING A RESTRICTION 1688 01:05:32,864 --> 01:05:34,899 OF THE FUNDING WE HAD FOR THE 1689 01:05:34,899 --> 01:05:37,869 COMMUNITIES THAT WE ABSOLUTELY 1690 01:05:37,869 --> 01:05:39,170 NEED TO REACH 1691 01:05:39,170 --> 01:05:41,506 >> JAYANTA: LET ME ADDRESS THIS 1692 01:05:41,506 --> 01:05:43,441 SQUARELY. YOU'RE NOT SAYING THE 1693 01:05:43,441 --> 01:05:45,510 KEYWORD. THE KEYWORD IS DEI. 1694 01:05:45,510 --> 01:05:46,778 THAT'S WHAT YOU NEED. 1695 01:05:46,778 --> 01:05:50,782 >> DISPARITY, UNDERREPRESENTED 1696 01:05:50,782 --> 01:05:52,584 >> JAYANTA: I BELIEVE AND I AM 1697 01:05:52,584 --> 01:05:54,052 COMMITTED ENTIRELY TO MAKE SURE 1698 01:05:54,052 --> 01:05:57,255 THE NIH ADDRESSES THE HEALTH 1699 01:05:57,255 --> 01:05:59,224 NEEDS OF THE MINORITIES IN THIS 1700 01:05:59,224 --> 01:06:01,292 COUNTRY. THERE'S NO WAY TO MAKE 1701 01:06:01,292 --> 01:06:02,761 AMERICA HEALTHY AGAIN UNLESS YOU 1702 01:06:02,761 --> 01:06:04,295 DO THAT AND I AM FULLY COMMIT 1703 01:06:04,295 --> 01:06:06,731 THAT HAD THE NIH WILL CONTINUE 1704 01:06:06,731 --> 01:06:07,032 TO DO THAT. 1705 01:06:07,032 --> 01:06:09,968 THAT SAID I THINK A LOT OF THE 1706 01:06:09,968 --> 01:06:11,970 PORTFOLIO GOT MARBLED WITH 1707 01:06:11,970 --> 01:06:14,773 FRANKLY UNSCIENTIFIC IDEAS. 1708 01:06:14,773 --> 01:06:17,475 IDEAS THAT ARE NOT IN PRINCIPLE 1709 01:06:17,475 --> 01:06:20,278 BUT FALSIFIABLE AS A WAY TO... 1710 01:06:20,278 --> 01:06:22,347 AND I THINK ALSO, IN ADDITION TO 1711 01:06:22,347 --> 01:06:24,649 BEING SCIENTIFICALLY HARD TO 1712 01:06:24,649 --> 01:06:32,090 DEFEND, IT ALSO WAS POLITICALLY 1713 01:06:32,090 --> 01:06:34,559 ALIGNED. IT WAS A POLITICAL 1714 01:06:34,559 --> 01:06:36,895 ETIOLOGY RATHER THAN A 1715 01:06:36,895 --> 01:06:37,796 SCIENTIFIC HYPOTHESIS. HOW BEST 1716 01:06:37,796 --> 01:06:41,299 TO REACH POPULATIONS OF PEOPLE 1717 01:06:41,299 --> 01:06:43,101 WITH IMPORTANT SCIENTIFIC 1718 01:06:43,101 --> 01:06:44,235 MESSAGES? THAT'S A POTENTIALLY 1719 01:06:44,235 --> 01:06:45,837 A SCIENTIFIC QUESTION I THINK. 1720 01:06:45,837 --> 01:06:48,540 BUT THAT, BUT LIKE SYSTEMIC 1721 01:06:48,540 --> 01:06:50,775 RACISM AS A REASON WHY 1722 01:06:50,775 --> 01:06:52,844 MINORITIES HAVE LOW, BAD HEALTH, 1723 01:06:52,844 --> 01:06:54,446 THAT'S NOT A SCIENTIFIC QUESTION 1724 01:06:54,446 --> 01:06:55,714 ACTUALLY. RIGHT? BECAUSE I 1725 01:06:55,714 --> 01:06:58,216 DON'T EACH KNOW IN PRINCIPLE HOW 1726 01:06:58,216 --> 01:06:59,884 YOU WOULD FALSIFY THAT. WHAT 1727 01:06:59,884 --> 01:07:02,754 DATA POINTS WOULD YOU DO? IT 1728 01:07:02,754 --> 01:07:05,490 DOESN'T MATCH THE CRITERIA OF 1729 01:07:05,490 --> 01:07:06,491 FALSIFICATION, FALSIFIABILITY 1730 01:07:06,491 --> 01:07:08,326 THAT'S THE CLASSIC DEMARCATION 1731 01:07:08,326 --> 01:07:10,395 PROBLEM FOR SCIENCE AND 1732 01:07:10,395 --> 01:07:10,762 NONSCIENCE. 1733 01:07:10,762 --> 01:07:13,331 I THINK IF WE FOCUS ON THE 1734 01:07:13,331 --> 01:07:17,268 CONCRETE THINGS. THAT SAY, 1735 01:07:17,268 --> 01:07:23,475 OKAY, WELL, IF YOU HAVE A HEALTH 1736 01:07:23,475 --> 01:07:25,877 FAIRS IN CHURCHES, THIS MAKES IT 1737 01:07:25,877 --> 01:07:29,180 EASIER TO DO, TO HAVE PUBLIC 1738 01:07:29,180 --> 01:07:32,150 HEALTH CAMPAIGNS ON MEASURING 1739 01:07:32,150 --> 01:07:34,753 HYPERTENSION IN MINORITY 1740 01:07:34,753 --> 01:07:35,353 POPULATIONS. THAT'S A 1741 01:07:35,353 --> 01:07:37,522 SCIENTIFIC QUESTION. YOU DO 1742 01:07:37,522 --> 01:07:38,757 THAT VERSUS SOME OTHER WAY OF 1743 01:07:38,757 --> 01:07:40,091 OUTREACH. THAT'S A SCIENTIFIC 1744 01:07:40,091 --> 01:07:41,526 QUESTION. RIGHT? THOSE ARE 1745 01:07:41,526 --> 01:07:42,627 THINGS YOU CAN CONCRETELY DO. 1746 01:07:42,627 --> 01:07:44,529 THOSE ARE THINGS WE OUGHT TO BE 1747 01:07:44,529 --> 01:07:46,765 ABLE TO ASK AND I'M NOT EVER 1748 01:07:46,765 --> 01:07:48,900 GOING TO OPPOSE ASKING THEM IN 1749 01:07:48,900 --> 01:07:53,271 MY LEADERSHIP. BY WILL -- BUT 1750 01:07:53,271 --> 01:07:56,674 I WILL OPPOSE ASKING THINGS THAT 1751 01:07:56,674 --> 01:08:00,745 ARE ETIOLOGICAL AT THEIR HEART 1752 01:08:00,745 --> 01:08:01,980 AND UNSCIENTIFIC. 1753 01:08:01,980 --> 01:08:04,649 I THINK A LOT OF THE PORTFOLIO 1754 01:08:04,649 --> 01:08:06,951 IN MANY AREAS LED UP TO THAT AND 1755 01:08:06,951 --> 01:08:10,755 LED US TO BE VULNERABLE TO 1756 01:08:10,755 --> 01:08:11,589 POLITI 1757 01:08:11,589 --> 01:08:14,159 POLITICAL CRITICISM. THIS 1758 01:08:14,159 --> 01:08:16,528 SHOULD NOT BE POLITICAL. AT ONE 1759 01:08:16,528 --> 01:08:18,763 TIME THIS WAS THE EASIEST JOB. 1760 01:08:18,763 --> 01:08:21,399 YOU BRAG ABOUT THE BRAIN, AND 1761 01:08:21,399 --> 01:08:23,535 YOU GO ABOUT THE HUMAN GENOME 1762 01:08:23,535 --> 01:08:25,103 PROJECT, YOU BRAG ABOUT ALL 1763 01:08:25,103 --> 01:08:26,504 THESE THINGS AND EVERYONE'S LIKE 1764 01:08:26,504 --> 01:08:27,872 WOW, THIS IS COOL. ALL THAT 1765 01:08:27,872 --> 01:08:29,574 STUFF IS REALLY COOL, WE JUST 1766 01:08:29,574 --> 01:08:31,976 NEED TO GET BACK TO THAT AND THE 1767 01:08:31,976 --> 01:08:33,144 AWAY FROM THE POLITICIZATION 1768 01:08:33,144 --> 01:08:34,345 ESPECIALLY THAT HAPPENED DURING 1769 01:08:34,345 --> 01:08:36,848 THE PANDEMIC. 1770 01:08:36,848 --> 01:08:37,415 >> THANK YOU. 1771 01:08:37,415 --> 01:08:41,519 >> WALTER: SO HERE AT THE N 1772 01:08:41,519 --> 01:08:43,221 ISHNIH 1773 01:08:43,221 --> 01:08:44,455 WE'RE INTERESTED IN FINDING 1774 01:08:44,455 --> 01:08:48,026 CURES FOR DISEASES THAT ARE REAL 1775 01:08:48,026 --> 01:08:51,095 BAD AND WE HAVE SOMEONE WHO HAS 1776 01:08:51,095 --> 01:08:54,766 WORKED MORE OF HIS LIFE IN ALS 1777 01:08:54,766 --> 01:08:57,502 AND ANOTHER DOCTOR WHO WORKED ON 1778 01:08:57,502 --> 01:08:59,137 ALS AND NOW UNFORTUNATELY HAS 1779 01:08:59,137 --> 01:09:01,840 ALS SO THE TRAGEDY OF THESE 1780 01:09:01,840 --> 01:09:02,974 DISEASES, THESE GUYS KNOW BUT 1781 01:09:02,974 --> 01:09:05,410 EVERYBODY KNOWS ABOUT IT BUT BOB 1782 01:09:05,410 --> 01:09:05,910 GO AHEAD. 1783 01:09:05,910 --> 01:09:07,812 >> BOB: THANK YOU FOR YOUR 1784 01:09:07,812 --> 01:09:09,280 COMMENTS. WE DEEPLY APPRECIATE 1785 01:09:09,280 --> 01:09:12,550 THEM. YOU ALLAYED MANY 1786 01:09:12,550 --> 01:09:13,952 CONCERNS, IT'S REFRESHING TO 1787 01:09:13,952 --> 01:09:16,154 TAKE A HARD LOOK AT SO MANY 1788 01:09:16,154 --> 01:09:18,790 ASPECTS OF AN INSTITUTION LIKE 1789 01:09:18,790 --> 01:09:20,091 THIS I PARTICULARLY APPLAUD THE 1790 01:09:20,091 --> 01:09:21,459 EFFORTS TO UNDERSTAND THE ROOT 1791 01:09:21,459 --> 01:09:24,562 CAUSES OF DIET RELATED CHRONIC 1792 01:09:24,562 --> 01:09:25,864 DISEASES SUCH AS FOREVER 1793 01:09:25,864 --> 01:09:28,132 CHEMICALS. THAT'S SPECTACULAR I 1794 01:09:28,132 --> 01:09:30,168 HOPE WE MAKE PROGRESS IN THAT 1795 01:09:30,168 --> 01:09:32,270 AREA. I WANT TO ASK YOU ABOUT 1796 01:09:32,270 --> 01:09:33,738 TWO FUNDING DOMAINS. YOU 1797 01:09:33,738 --> 01:09:35,473 MENTIONED ANIMAL RESEARCH. ONE 1798 01:09:35,473 --> 01:09:38,743 OF THE THINGS THAT HAS 1799 01:09:38,743 --> 01:09:39,878 BEDEVILLED IS THE REQUIREMENT TO 1800 01:09:39,878 --> 01:09:43,548 USE NONHUMAN PRIMATES. MONKEYS. 1801 01:09:43,548 --> 01:09:45,083 I WONDER HOW YOUR VIEW WILL BE 1802 01:09:45,083 --> 01:09:47,585 IN TERMS OF FUNDING SUCH 1803 01:09:47,585 --> 01:09:49,921 STUDIES. BECAUSE THEY ARE 1804 01:09:49,921 --> 01:09:51,189 ETHICALLY CHALLENGING FOR ONE 1805 01:09:51,189 --> 01:09:53,324 THEY'RE INCREDIBLY EXPENSIVE AND 1806 01:09:53,324 --> 01:09:56,861 AT A TEMPORAL LEVEL THEY SLOW 1807 01:09:56,861 --> 01:09:58,796 DOWN THE WAY WE MOVE FROM ANIMAL 1808 01:09:58,796 --> 01:10:00,698 TO HUMAN STUDIES AND NUMBER TWO 1809 01:10:00,698 --> 01:10:02,333 WHICH IS SORT OF PREDICTABLE. 1810 01:10:02,333 --> 01:10:04,369 WHAT IS YOUR VIEW OF HOW WE 1811 01:10:04,369 --> 01:10:05,570 SHOULD PROCEED WITH VACCINE 1812 01:10:05,570 --> 01:10:07,939 RELATED RESEARCH BECAUSE I KNOW 1813 01:10:07,939 --> 01:10:10,842 THAT'S ANOTHER BIG ISSUE HERE. 1814 01:10:10,842 --> 01:10:11,542 THANK YOU 1815 01:10:11,542 --> 01:10:14,746 >> JAYANTA: YEAH, THANK YOU, 1816 01:10:14,746 --> 01:10:19,117 BOB, FOR THAT, ON ONE, THE FDA I 1817 01:10:19,117 --> 01:10:24,289 THINK IS, ALSO MOVED AWAY FROM 1818 01:10:24,289 --> 01:10:25,990 ROUTINELY REQUIRING ANIMAL 1819 01:10:25,990 --> 01:10:27,558 STUDIES FOR ADVANCES. 1820 01:10:27,558 --> 01:10:29,160 SPECIFICALLY ABOUT THE ROUTINE 1821 01:10:29,160 --> 01:10:30,461 REQUIREMENT FOR IF I'M 1822 01:10:30,461 --> 01:10:34,365 UNDERSTANDING CORRECTLY FOR 1823 01:10:34,365 --> 01:10:40,538 NONHUMAN PRIMATES. IT DOESN' 1824 01:10:40,538 --> 01:10:41,306 TRANSLATE INTO KNOWLEDGE THAT 1825 01:10:41,306 --> 01:10:42,674 WILL BE DONE IN HUMANS. I THINK 1826 01:10:42,674 --> 01:10:45,743 THAT THAT, WHAT WE'RE TRYING TO 1827 01:10:45,743 --> 01:10:49,547 DO IS ASK SCIENTISTS TO THINK. 1828 01:10:49,547 --> 01:10:50,615 IS THIS NECESSARY? IF WE WANT 1829 01:10:50,615 --> 01:10:52,183 TO UNDERSTAND HOW TO IMPROVE 1830 01:10:52,183 --> 01:10:54,452 HUMAN HEALTH IN AND THE ANSWER 1831 01:10:54,452 --> 01:10:55,954 IS NOT ALWAYS YES JUST BECAUSE 1832 01:10:55,954 --> 01:10:57,555 WE ALWAYS DO IT DOESN'T MEAN WE 1833 01:10:57,555 --> 01:10:58,756 SHOULD ALWAYS DO IT AND THERE 1834 01:10:58,756 --> 01:11:00,692 ARE ALTERNATIVES NOW AVAILABLE 1835 01:11:00,692 --> 01:11:02,193 THAT WEREN'T AVAILABLE BEFORE 1836 01:11:02,193 --> 01:11:05,530 AND WE SHOULD AVAIL OURSELVES OF 1837 01:11:05,530 --> 01:11:07,532 THEM. ON THE SECOND QUESTION 1838 01:11:07,532 --> 01:11:09,834 ABOUT VACCINES THE NIH IS 1839 01:11:09,834 --> 01:11:11,135 COMMITTED TO DEVELOPMENT OF 1840 01:11:11,135 --> 01:11:12,804 VACCINES. THERE'S NO CHANGE IN 1841 01:11:12,804 --> 01:11:15,440 THAT. I THINK KEY THING FOR ME 1842 01:11:15,440 --> 01:11:17,542 IS THAT WHEN WE, LET'S JUST SAY, 1843 01:11:17,542 --> 01:11:21,512 LET'S GO BACK TO AUTISM, RIGHT? 1844 01:11:21,512 --> 01:11:22,547 AUTISM SPECIFICALLY I PERSONALLY 1845 01:11:22,547 --> 01:11:25,917 HAVE LOOKED AT THE NIH, THE 1846 01:11:25,917 --> 01:11:29,120 LITERATURE ON MMR AND AUTISM AND 1847 01:11:29,120 --> 01:11:30,588 I DON'T BELIEVE THERE'S A LINK. 1848 01:11:30,588 --> 01:11:31,756 I DON'T BELIEVE THE LITERATURE 1849 01:11:31,756 --> 01:11:33,491 SUPPORTS THIS LINK. THERE'S 1850 01:11:33,491 --> 01:11:34,826 LOTS OF GOOD EVIDENCE THERE 1851 01:11:34,826 --> 01:11:36,728 PROBABLY ISN'T. THAT SAID, 1852 01:11:36,728 --> 01:11:38,496 EVERY SINGLE VACCINE THAT WE 1853 01:11:38,496 --> 01:11:40,398 STUDIED HASN'T BEEN STUDIED TO 1854 01:11:40,398 --> 01:11:43,067 THE SAME EXTENT AS THE MMR 1855 01:11:43,067 --> 01:11:44,802 VACCINE AND IF WE ASK A QUESTION 1856 01:11:44,802 --> 01:11:46,270 LIKE WHAT IS THE ETIOLOGY OF 1857 01:11:46,270 --> 01:11:48,840 AUTISM AND WE IN ADVANCE 1858 01:11:48,840 --> 01:11:53,044 PREJUDGE IT AND SAY WE ARE NOT 1859 01:11:53,044 --> 01:11:53,711 ALLOWED TO HAVE THIS HYPOTHESIS 1860 01:11:53,711 --> 01:11:55,913 AS PART OF IT BUT OTHERS ARE 1861 01:11:55,913 --> 01:12:00,118 ALLOWED THE PUBLIC WON'T BELIEVE 1862 01:12:00,118 --> 01:12:03,154 US AND IT'S BAD SCIENCE. WE'RE 1863 01:12:03,154 --> 01:12:06,024 NOT IN THE BUSINESS OF PUBLIC 1864 01:12:06,024 --> 01:12:06,758 RELATIONS BUT DOING SCIENCE AND 1865 01:12:06,758 --> 01:12:08,459 ASKING QUESTIONS ABOUT SCIENCE. 1866 01:12:08,459 --> 01:12:10,261 AND THAT MEANS WE SHOULD BE 1867 01:12:10,261 --> 01:12:12,530 ALLOWED TO ASK QUESTIONS THAT 1868 01:12:12,530 --> 01:12:16,401 THE PR PEOPLE DON'T WANT US TO 1869 01:12:16,401 --> 01:12:18,536 ASK. I THINK VACCINES ARE 1870 01:12:18,536 --> 01:12:20,038 TREMENDOUSLY IMPORTANT 1871 01:12:20,038 --> 01:12:21,539 TECHNOLOGY, PROBABLY THE MOST 1872 01:12:21,539 --> 01:12:22,673 IMPORTANT INNOVATION IN BIO 1873 01:12:22,673 --> 01:12:24,275 MEDICINE FOR PREVENTION OF 1874 01:12:24,275 --> 01:12:24,542 DISEASES. 1875 01:12:24,542 --> 01:12:27,178 I REMAIN COMMITTED TO THEM BUT 1876 01:12:27,178 --> 01:12:29,580 NOT EVERY VACCINE HAS THE SAME 1877 01:12:29,580 --> 01:12:33,718 SAFETY PROFILES AS THE SAFEST 1878 01:12:33,718 --> 01:12:37,188 VACCINES, THE, AS THE 1879 01:12:37,188 --> 01:12:37,889 EPIDEMIOLOGY OF DISEASE CHANGES 1880 01:12:37,889 --> 01:12:40,458 THE BENEFIT PROFILES OF SOME 1881 01:12:40,458 --> 01:12:44,529 VACCINES MAY CHANGE. WE DON'T 1882 01:12:44,529 --> 01:12:45,930 ROUTINELY VACCINATE THE U.S. FOR 1883 01:12:45,930 --> 01:12:47,298 YELLOW FEVER BECAUSE IT'S NOT 1884 01:12:47,298 --> 01:12:48,900 ENDEMIC HERE. IT REALLY MATTERS 1885 01:12:48,900 --> 01:12:52,003 SO THINKING THROUGH THE 1886 01:12:52,003 --> 01:12:52,603 EPIDEMIOLOGY, THINKING 1887 01:12:52,603 --> 01:12:53,671 SCIENTIFICALLY RATHER THAN AS A 1888 01:12:53,671 --> 01:12:55,673 P R KIND OF THING IS THE WAY 1889 01:12:55,673 --> 01:12:57,008 FORWARD FOR VACCINES. 1890 01:12:57,008 --> 01:12:58,743 SOME OF THE BIG CONCERNS THE 1891 01:12:58,743 --> 01:12:59,777 PARENTS HAVE MAY TURN OUT TO BE 1892 01:12:59,777 --> 01:13:01,579 TRUE AND OUR JOB IS TO ANSWER 1893 01:13:01,579 --> 01:13:04,882 THOSE QUESTIONS NOT TO PREJUDGE 1894 01:13:04,882 --> 01:13:05,083 TELL. 1895 01:13:05,083 --> 01:13:06,751 >> THANK YOU, THANK YOU. 1896 01:13:06,751 --> 01:13:10,154 >> WALTER: YOU PROMISED TO GO TO 1897 01:13:10,154 --> 01:13:14,258 11:15. IT'S 11:16. DO YOU WANT 1898 01:13:14,258 --> 01:13:18,296 TO TAKE MORE? 1899 01:13:18,296 --> 01:13:25,103 >> I'M HAPPY TO KEEP GOING. 1900 01:13:25,103 --> 01:13:28,406 >> WALTER: JIM WU, STROKE 1901 01:13:28,406 --> 01:13:29,607 INVESTIGATOR AND PHYSICIAN. 1902 01:13:29,607 --> 01:13:32,276 >> JIM: THANKS, WALTER AND 1903 01:13:32,276 --> 01:13:33,678 DR. WHAT TA CHARIA, THANK YOU 1904 01:13:33,678 --> 01:13:35,680 FOR ADDRESSING THE COUNCIL I 1905 01:13:35,680 --> 01:13:38,483 FEEL ASSURE THAT HAD YOU WERE A 1906 01:13:38,483 --> 01:13:41,152 FORMER NIH FUNDED INVESTIGATOR 1907 01:13:41,152 --> 01:13:42,320 AND YOU ARE IN THE POSITION TO 1908 01:13:42,320 --> 01:13:46,591 SHAPE THE DIRECTION OF THE NIH. 1909 01:13:46,591 --> 01:13:48,626 MY QUESTION IS THE TIME YOU 1910 01:13:48,626 --> 01:13:50,761 ENTERED, THE MOST CHAOTIC PERIOD 1911 01:13:50,761 --> 01:13:52,196 IN NIH HISTORY AND I THINK WE 1912 01:13:52,196 --> 01:13:54,298 ALL AGREE WITH THAT THE STUDIES 1913 01:13:54,298 --> 01:13:58,169 THAT I THINK ARE MOST AT RISK SO 1914 01:13:58,169 --> 01:13:59,704 THIS SMALL CHAOS MIGHT HAVE 1915 01:13:59,704 --> 01:14:01,973 LONG-TERM CONSEQUENCES THAT I 1916 01:14:01,973 --> 01:14:03,674 WORRY ABOUT AND THE STUDIES THAT 1917 01:14:03,674 --> 01:14:05,543 ARE MOST AT RISK ARE CLINICAL 1918 01:14:05,543 --> 01:14:08,079 TRIALS THAT ARE ONGOING. AND 1919 01:14:08,079 --> 01:14:12,416 MAY BE DISRUPTED, AND SOME OF 1920 01:14:12,416 --> 01:14:14,752 THE LONGER TERM CLINICAL TRIALS 1921 01:14:14,752 --> 01:14:17,155 MAY BE INVALIDATED BECAUSE THE 1922 01:14:17,155 --> 01:14:18,122 RANDOMIZATION MIGHT BE DISRU 1923 01:14:18,122 --> 01:14:21,459 DISRUPTED. AND I CAN GIVE YOU A 1924 01:14:21,459 --> 01:14:25,029 CONCRETE EXAMPLE. ONE OF THE 1925 01:14:25,029 --> 01:14:29,700 STUDIES BEING DONE HERE AT WASH 1926 01:14:29,700 --> 01:14:32,303 U IS THE DIANNE TRIAL. BY THE 1927 01:14:32,303 --> 01:14:33,738 NATURE OF PREVENTION THE 1928 01:14:33,738 --> 01:14:34,772 TREATMENT REQUIRES LONG PERIODS 1929 01:14:34,772 --> 01:14:36,040 OF TIME, PROBABLY NOT JUST FIVE 1930 01:14:36,040 --> 01:14:40,878 YEARS BUT TEN YEARS. AND SO THE 1931 01:14:40,878 --> 01:14:42,280 CONTINUOUS FUNDING OF TRIALS 1932 01:14:42,280 --> 01:14:43,614 LIKE THIS IS INCREDIBLY 1933 01:14:43,614 --> 01:14:45,816 IMPORTANT OTHERWISE THE HUGE 1934 01:14:45,816 --> 01:14:48,019 INVESTMENT THAT HAS GONE INTO IT 1935 01:14:48,019 --> 01:14:50,288 MAY BE GONE TO WASTE. AND SO MY 1936 01:14:50,288 --> 01:14:53,691 QUESTION TO YOU IS, ARE THERE 1937 01:14:53,691 --> 01:14:56,160 MECHANISMS IN PLACE THAT MIGHT 1938 01:14:56,160 --> 01:14:57,595 HELP STUDIES THAT ARE AT RISK 1939 01:14:57,595 --> 01:14:59,630 THAT MIGHT BE DISRUPTED BY ALL 1940 01:14:59,630 --> 01:15:00,731 THE CHAOS THAT YOU EXPERIENCED 1941 01:15:00,731 --> 01:15:04,035 WHEN YOU FIRST ENTERED THE 1942 01:15:04,035 --> 01:15:07,738 OFFICE? 1943 01:15:07,738 --> 01:15:08,940 >> JAYANTA: THERE WAS A SENATOR 1944 01:15:08,940 --> 01:15:10,575 THAT ASKED ME ABOUT THIS 1945 01:15:10,575 --> 01:15:13,377 SPECIFICALLY. YOU ARE 1946 01:15:13,377 --> 01:15:14,745 WELL-REPRESENTED IN THIS AND I 1947 01:15:14,745 --> 01:15:16,314 HAVE LOOKED AT THE TRIAL. I 1948 01:15:16,314 --> 01:15:18,416 THINK THE TRIAL IS AN AMAZINGLY 1949 01:15:18,416 --> 01:15:20,051 IMPORTANT TRIAL. THERE ARE 1950 01:15:20,051 --> 01:15:21,719 ASPECTS OF THE TRIAL, FOR 1951 01:15:21,719 --> 01:15:22,587 INSTANCE, THERE WAS AN 1952 01:15:22,587 --> 01:15:23,688 OBSERVATIONAL STUDY LINKED WITH 1953 01:15:23,688 --> 01:15:24,422 THE TRIAL THAT DIDN'T SCORE 1954 01:15:24,422 --> 01:15:26,757 WELL. I'M NOT GOING TO PUT, I'M 1955 01:15:26,757 --> 01:15:29,660 NOT GOING TO, LIKE, 1956 01:15:29,660 --> 01:15:31,495 SCIENTIFICALLY, THE REVIEW 1957 01:15:31,495 --> 01:15:33,030 PROCESS IS NOT SOMETHING I'M 1958 01:15:33,030 --> 01:15:34,599 GOING TO PUT MY THUMB ON THE 1959 01:15:34,599 --> 01:15:36,167 SCALE OF THAT. AS FAR AS I CAN 1960 01:15:36,167 --> 01:15:37,668 TELL THERE'S STILL CONTINUED 1961 01:15:37,668 --> 01:15:39,537 SUPPORT FOR THE DIANNE TRIAL IN 1962 01:15:39,537 --> 01:15:41,272 PARTICULAR AND FOR CLINICAL 1963 01:15:41,272 --> 01:15:44,609 TRIALS GENERALLY. I SPOKE WITH 1964 01:15:44,609 --> 01:15:46,410 MATT WHO WAS THE ACTING DIRECTOR 1965 01:15:46,410 --> 01:15:50,448 BEFORE I ARRIVED. WHAT HE HAD 1966 01:15:50,448 --> 01:15:54,752 DONE IS THROUGH THE TODAY I 1967 01:15:54,752 --> 01:15:59,156 DON'T SAY A-- CHAOS AND THE 1968 01:15:59,156 --> 01:16:01,058 TRIALS AND HE WORKED TO NOT 1969 01:16:01,058 --> 01:16:03,127 DISRUPT THE PATIENT CARE THAT 1970 01:16:03,127 --> 01:16:03,394 HAPPENED. 1971 01:16:03,394 --> 01:16:04,662 THAT WAS HIS PRIORITY AND THAT'S 1972 01:16:04,662 --> 01:16:08,899 MY PRIORITY AS WELL THAT THE 1973 01:16:08,899 --> 01:16:14,772 CHAOS DOES NOT HARM PATIENTS. 1974 01:16:14,772 --> 01:16:18,442 THE NIH REMAINS COMMITTED TO 1975 01:16:18,442 --> 01:16:22,747 DOING THESE TRIALS. I SAW, 1976 01:16:22,747 --> 01:16:25,449 THERE WAS A PUSH, A REQUIREMENT 1977 01:16:25,449 --> 01:16:26,384 FROM THE ADMINISTRATION THAT WE 1978 01:16:26,384 --> 01:16:28,986 CUT 30% OF OUR CONTRACTS. AND 1979 01:16:28,986 --> 01:16:31,689 ONE OF THE CONTRACTS THAT WAS 1980 01:16:31,689 --> 01:16:34,125 PROPOSED TO BE CUT WAS THE 1981 01:16:34,125 --> 01:16:37,228 WOMAN'S HEALTH INITIATIVE, A 1982 01:16:37,228 --> 01:16:37,862 TREMENDOUSLY IMPORTANT CLINICAL 1983 01:16:37,862 --> 01:16:39,130 TRIAL THAT'S STILL ONGOING. AND 1984 01:16:39,130 --> 01:16:42,767 I MADE SURE THAT THAT GOT 1985 01:16:42,767 --> 01:16:45,836 REVERSED. IT'S A REALLY 1986 01:16:45,836 --> 01:16:47,171 IMPORTANT PRIORITY MIND THAT 1987 01:16:47,171 --> 01:16:49,206 THESE CLINICAL TRIALS ESPECIALLY 1988 01:16:49,206 --> 01:16:50,308 THESE LARGE-SCALE CLINICAL 1989 01:16:50,308 --> 01:16:50,975 TRIALS CONTINUE BECAUSE THAT'S 1990 01:16:50,975 --> 01:16:52,543 WHERE WE LEARN A LOT ABOUT WHAT 1991 01:16:52,543 --> 01:16:56,247 WORKS IN HUMAN POPULATIONS OVER 1992 01:16:56,247 --> 01:16:58,749 LONG-TERM. AND SO I... THAT'S 1993 01:16:58,749 --> 01:17:00,985 SOMETHING I'M PERSONALLY 1994 01:17:00,985 --> 01:17:01,952 COMMITTED TO. IF THERE'S 1995 01:17:01,952 --> 01:17:03,854 EXAMPLE WHERE IS THESE ARE 1996 01:17:03,854 --> 01:17:04,488 THREATENED. THESE BRING IT TO 1997 01:17:04,488 --> 01:17:07,091 MY ATTENTION. I WILL LOOK INTO 1998 01:17:07,091 --> 01:17:09,093 IT. DIANNE I THINK HAS BEEN 1999 01:17:09,093 --> 01:17:10,761 PROTECTED. IT'S NOT BEEN CUT. 2000 01:17:10,761 --> 01:17:11,729 THERE ARE PARTS OF IT THAT 2001 01:17:11,729 --> 01:17:13,798 DIDN'T SCORE WELL, I AM NOT 2002 01:17:13,798 --> 01:17:14,932 GOING TO DO ANYTHING ABOUT IT 2003 01:17:14,932 --> 01:17:16,767 BECAUSE IT'S THE SCIENTIFIC 2004 01:17:16,767 --> 01:17:18,002 COMMUNITIES THAT DECIDE THAT BUT 2005 01:17:18,002 --> 01:17:20,037 THAT'S THE NORMAL SCIENTIFIC 2006 01:17:20,037 --> 01:17:25,976 PROCESS NOT A POLITICAL ONE. 2007 01:17:25,976 --> 01:17:28,879 >> THANK YOU VERY MUCH 2008 01:17:28,879 --> 01:17:30,581 >> NEXT IS AMY BRYNNE A LOT OF 2009 01:17:30,581 --> 01:17:35,019 OUR WORK, JAY S IS TRYING TO GET 2010 01:17:35,019 --> 01:17:39,190 AT THESE RARE NEUROLOGICAL 2011 01:17:39,190 --> 01:17:40,224 DISEASES THAT STOP KIDS FROM 2012 01:17:40,224 --> 01:17:42,993 DEVELOPING AND THINGS LIKE 2013 01:17:42,993 --> 01:17:46,764 EPILEPSY WHICH IS QUITE DESE 2014 01:17:46,764 --> 01:17:47,465 SCORE, AMY? 2015 01:17:47,465 --> 01:17:50,167 >> AMY: NOT ONLY AM I A FORMER 2016 01:17:50,167 --> 01:17:53,971 CE,OF AN ADVOCACY ORGANIZATION 2017 01:17:53,971 --> 01:17:56,640 BUT I'M ONE OF THE FEW PUBLIC 2018 01:17:56,640 --> 01:17:57,274 FACING MEMBERS REPRESENTING THE 2019 01:17:57,274 --> 01:17:58,743 CARER COMMUNITY. 2020 01:17:58,743 --> 01:18:00,478 I FOUND YOUR OPENING SLIDE ABOUT 2021 01:18:00,478 --> 01:18:02,747 THE DATA REGARDING THE PUBLIC'S 2022 01:18:02,747 --> 01:18:04,949 TRUST IN SCIENCE JUST ABSOLUTELY 2023 01:18:04,949 --> 01:18:06,050 DISTRESSING BUT FROM A 2024 01:18:06,050 --> 01:18:06,917 LEADERSHIP PERSPECTIVE IT 2025 01:18:06,917 --> 01:18:08,786 APPEARS VERY CLEAR THAT IS YOUR 2026 01:18:08,786 --> 01:18:10,755 NORTH STAR. IN SETTING STRATEGY 2027 01:18:10,755 --> 01:18:12,957 AND I APPRECIATE THAT. SO MY 2028 01:18:12,957 --> 01:18:15,192 QUESTION TO YOU IS, IF YOUR MAIN 2029 01:18:15,192 --> 01:18:17,728 GOAL IS TO IMPROVE THE PUBLIC'S 2030 01:18:17,728 --> 01:18:19,964 TRUST IN SCIENCES, HOW ARE YOU 2031 01:18:19,964 --> 01:18:21,632 GOING TO GO ABOUT MORE ENGAGE 2032 01:18:21,632 --> 01:18:23,734 WITH THE PATIENT AND CAREGIVER 2033 01:18:23,734 --> 01:18:25,970 ADVOCACY COMMUNITY TO HELP YOU 2034 01:18:25,970 --> 01:18:26,270 IN THAT? 2035 01:18:26,270 --> 01:18:28,072 >> JAYANTA: LET ME GIVE YOU AN 2036 01:18:28,072 --> 01:18:31,709 EXAMPLE FROM THE AUTISM PROJECT. 2037 01:18:31,709 --> 01:18:36,814 RIGHT? SO THE AUTISM PROJECT, 2038 01:18:36,814 --> 01:18:38,582 THE ANNOUNCEMENT ABOUT IT GOT 2039 01:18:38,582 --> 01:18:41,118 LEAKED EARLIER THAN I WOULD HAVE 2040 01:18:41,118 --> 01:18:41,952 HOPED. THERE'S CONNECTIONS WITH 2041 01:18:41,952 --> 01:18:44,922 THE AUTISM COMMUNITY. THE 2042 01:18:44,922 --> 01:18:47,691 PARENTS THAT CARE FOR KIDS, THE 2043 01:18:47,691 --> 01:18:49,160 GROUPS THAT REPRESENT THEM AS 2044 01:18:49,160 --> 01:18:50,795 PART OF, OF THAT ANNOUNCEMENTS, 2045 01:18:50,795 --> 01:18:53,731 AND PART OF THAT. AND THAT'S 2046 01:18:53,731 --> 01:18:54,765 EXACTLY WHAT I INTEND TO DO. 2047 01:18:54,765 --> 01:18:56,300 I'M DOING OUTREACH TO THESE 2048 01:18:56,300 --> 01:18:58,769 COMMUNITIES, GOING TO GO MEET 2049 01:18:58,769 --> 01:19:00,604 WITH FOLKS, I DON'T BELIEVE THAT 2050 01:19:00,604 --> 01:19:02,540 WE CAN SUCCEED AS AN 2051 01:19:02,540 --> 01:19:04,875 ORGANIZATION IN OUR MISSION OF 2052 01:19:04,875 --> 01:19:06,444 ADVANCING THE HEALTH AND 2053 01:19:06,444 --> 01:19:07,278 LONGEVITY OF AMERICAN PEOPLE 2054 01:19:07,278 --> 01:19:11,382 UNLESS WE SERVE AS PARTNERS OF 2055 01:19:11,382 --> 01:19:13,417 THE PEOPLE. WE'RE NOT JUST 2056 01:19:13,417 --> 01:19:15,453 POINTY HEADED SCIENTISTS FROM 2057 01:19:15,453 --> 01:19:18,756 ABOVE POINTING OUT COOL THINGS. 2058 01:19:18,756 --> 01:19:20,658 WE HAVE TO WORK TOGETHER WITH 2059 01:19:20,658 --> 01:19:21,859 PATIENT COMMUNITIES SO WE 2060 01:19:21,859 --> 01:19:22,493 UNDERSTAND WHAT QUESTIONINGS 2061 01:19:22,493 --> 01:19:24,795 THEY HAVE AND WE ADDRESS THOSE 2062 01:19:24,795 --> 01:19:26,564 QUESTIONS. THAT'S ONLY THE WAY 2063 01:19:26,564 --> 01:19:28,365 FORWARD. I HAVE SEEN THIS IN MY 2064 01:19:28,365 --> 01:19:32,837 OWN WORK BEFORE I GOT HERE. AND 2065 01:19:32,837 --> 01:19:34,271 I AM ABSOLUTELY COMMITTED TO 2066 01:19:34,271 --> 01:19:36,474 THAT. WE WILL DO THAT WITH 2067 01:19:36,474 --> 01:19:37,942 AUTISM, WITH ALZHEIMER'S WITH 2068 01:19:37,942 --> 01:19:39,343 EVERY SINGLE ASPECT OF OUR 2069 01:19:39,343 --> 01:19:41,612 PORTFOLIO. THE PATIENT 2070 01:19:41,612 --> 01:19:42,279 COMMUNITIES HAVE A PLAY A PRETTY 2071 01:19:42,279 --> 01:19:43,714 FUNDAMENTAL ROLE I MENTIONED 2072 01:19:43,714 --> 01:19:45,716 ABOUT GAIN OF FUNCTION ABOUT THE 2073 01:19:45,716 --> 01:19:46,951 PROBLEMS OF GAIN OF FUNCTION YOU 2074 01:19:46,951 --> 01:19:48,719 KNOW IN MY VIEW PROBABLY THE 2075 01:19:48,719 --> 01:19:50,754 BIGGEST PROBLEM THERE IS THAT 2076 01:19:50,754 --> 01:19:52,189 SCIENTISTS DECIDED WHAT RISKS 2077 01:19:52,189 --> 01:19:53,324 THEY WERE WILLING TO TAKE ON 2078 01:19:53,324 --> 01:19:55,025 BEHALF OF THE ENTIRE HUMAN 2079 01:19:55,025 --> 01:19:58,229 POPULATION WITH EXPERIMENTS. 2080 01:19:58,229 --> 01:20:02,166 THE MISTAKE WAS FAILURE OF 2081 01:20:02,166 --> 01:20:02,800 STAKEHOLDER ENGAGEMENT THERE. 2082 01:20:02,800 --> 01:20:06,604 WE'RE GOING TO FIX THAT. ACROSS 2083 01:20:06,604 --> 01:20:08,639 THE ENTIRE PORTFOLIO. 2084 01:20:08,639 --> 01:20:11,242 >> I APPRECIATE THAT. ALLOW THE 2085 01:20:11,242 --> 01:20:14,478 PATIENT AND COMMUNITY TO BE YOUR 2086 01:20:14,478 --> 01:20:15,846 AMBASSADORS TOO 2087 01:20:15,846 --> 01:20:16,714 >> JAYANTA: ABSOLUTELY, I'M NOT 2088 01:20:16,714 --> 01:20:19,383 GOING TO SUCCEED WITHOUT THAT. 2089 01:20:19,383 --> 01:20:21,418 WE WON'T WHAT WE'RE SUPPOSED TO 2090 01:20:21,418 --> 01:20:25,155 DO. APPRECIATE YOUR EXCELLENTS, 2091 01:20:25,155 --> 01:20:26,757 AMY 2092 01:20:26,757 --> 01:20:28,125 >> KATIE: THANKS. 2093 01:20:28,125 --> 01:20:29,693 >> WALTER: YOU'RE HANGING IN 2094 01:20:29,693 --> 01:20:33,163 WITH US, JAY? SO LYNN DEBAR IS 2095 01:20:33,163 --> 01:20:43,707 A RESEARCHER IN KAIZER, PAIN IS 2096 01:20:45,142 --> 01:20:46,544 THE LEADING CAUSE OF DISABILITY 2097 01:20:46,544 --> 01:20:48,812 IN THE UNITED STATES. LYNN? 2098 01:20:48,812 --> 01:20:50,281 >> LYNN: YEAH, THANK YOU SO MUCH 2099 01:20:50,281 --> 01:20:52,182 FOR YOUR THOUGHTFUL AND 2100 01:20:52,182 --> 01:20:53,250 COMPREHENSIVE OVERVIEW THAT WAS 2101 01:20:53,250 --> 01:20:54,752 REALLY HELPFUL AND AS SOMEBODY 2102 01:20:54,752 --> 01:20:56,554 WHO DOES A LOT OF VERY APPLIED 2103 01:20:56,554 --> 01:20:58,822 WORK, PRAGMATIC TRIALS, THINGS 2104 01:20:58,822 --> 01:21:01,525 WITH COST-EFFECTIVENESS IN REAL 2105 01:21:01,525 --> 01:21:03,093 WORLD POPULATIONS, I WAS STRUCK 2106 01:21:03,093 --> 01:21:05,930 BY YOUR STARTING WITH YOUR 2107 01:21:05,930 --> 01:21:08,933 VISION BY REALLY A FOCUS ON 2108 01:21:08,933 --> 01:21:10,768 IMPROVING POPULATION HEALTH AND 2109 01:21:10,768 --> 01:21:14,738 ALSO I KNOW YOU'RE A HEALTH 2110 01:21:14,738 --> 01:21:16,373 ECONOMIST AND WAS INTERESTED IN 2111 01:21:16,373 --> 01:21:17,641 SOME FURTHER THOUGHTS BOTH IN 2112 01:21:17,641 --> 01:21:20,010 MATERIALS OF WHAT ARE SOME OF 2113 01:21:20,010 --> 01:21:22,446 THE CONCRETE WAYS IN WHICH YOU 2114 01:21:22,446 --> 01:21:25,382 SEE TRYING TO PROMOTE POPULATION 2115 01:21:25,382 --> 01:21:27,718 HEALTH RESEARCH WITHIN NIH 2116 01:21:27,718 --> 01:21:29,119 EXTRAMURAL RESEARCH BUT ALSO IN 2117 01:21:29,119 --> 01:21:34,458 TERMS OF SOME OF THE NUANCES 2118 01:21:34,458 --> 01:21:35,859 WITH HEALTH ECONOMICS WHERE YOU 2119 01:21:35,859 --> 01:21:37,861 MIGHT GET A COST OFFSET OVERALL 2120 01:21:37,861 --> 01:21:39,763 BUT IT'S NOT INFLUENCING THE 2121 01:21:39,763 --> 01:21:40,531 FOLKS IN THE SYSTEM WHO ARE 2122 01:21:40,531 --> 01:21:44,368 REALLY PULLING THE LEVERS SO 2123 01:21:44,368 --> 01:21:46,236 WOULD APPRECIATE A MORE DRILL 2124 01:21:46,236 --> 01:21:48,906 DOWN IN HOW YOU MIGHT HELP TO 2125 01:21:48,906 --> 01:21:53,444 SHAPE SOME OF THAT WORK. THANK 2126 01:21:53,444 --> 01:21:53,611 YOU 2127 01:21:53,611 --> 01:21:57,047 >> JAYANTA: I THINK IN 2010 THE 2128 01:21:57,047 --> 01:21:58,616 NIH ISSUED A STATEMENT SAYING 2129 01:21:58,616 --> 01:21:59,750 THAT HEALTH ECONOMICS WAS GOING 2130 01:21:59,750 --> 01:22:02,753 TO BE DEPRIORITIZED. I REMEMBER 2131 01:22:02,753 --> 01:22:04,188 THIS DISTINCTLY BECAUSE OF MY 2132 01:22:04,188 --> 01:22:06,757 FIELD AND I THINK THAT WAS A 2133 01:22:06,757 --> 01:22:08,459 MISTAKE. IT'S NOT JUST HEALTH 2134 01:22:08,459 --> 01:22:10,461 ECONOMICS. BUT LIKE POPULATION 2135 01:22:10,461 --> 01:22:13,063 HEALTH I THINK THAT HAS TO BE 2136 01:22:13,063 --> 01:22:14,598 DEPRIORITIZED AND I WON'T BE 2137 01:22:14,598 --> 01:22:15,599 UNDER MY WATCH. IT'S GOING TO 2138 01:22:15,599 --> 01:22:18,769 BE AN IMPORTANT PART OF THE NIH 2139 01:22:18,769 --> 01:22:20,604 PORTFOLIO. WE HAVE TO DO WORK 2140 01:22:20,604 --> 01:22:22,973 THAT IS ON HUMAN HEALTH THAT IS 2141 01:22:22,973 --> 01:22:26,076 OF COURSE THE SORT OF HALLMARK 2142 01:22:26,076 --> 01:22:26,744 BASIC SCIENCE WORK THAT WE 2143 01:22:26,744 --> 01:22:28,479 ABSOLUTELY HAVE TO HAVE A 2144 01:22:28,479 --> 01:22:29,713 COMMITMENT TO THAT BUT EQUALLY 2145 01:22:29,713 --> 01:22:33,517 WE HAVE TO HAVE A COMMITMENT TO 2146 01:22:33,517 --> 01:22:34,752 POPULATION HEALTH SCIENCES. AND 2147 01:22:34,752 --> 01:22:39,556 A LOT OF MY WORK IS OUTSIDE, YOU 2148 01:22:39,556 --> 01:22:41,825 KNOW, OUTSIDE THE, WAS FOCUSED 2149 01:22:41,825 --> 01:22:46,764 ON EXACTLY THOSE ITEMS. WHAT 2150 01:22:46,764 --> 01:22:49,500 THAT PORTFOLIO WILL LOOK LIKE, 2151 01:22:49,500 --> 01:22:52,336 IT'S HARD TO SAY EXACTLY, BUT 2152 01:22:52,336 --> 01:22:53,971 THE KEY THING IS IT WILL ADDRESS 2153 01:22:53,971 --> 01:22:56,040 THE KEY QUESTIONS THAT THE 2154 01:22:56,040 --> 01:22:59,009 COMMUNITIES HAVE THAT WE'RE 2155 01:22:59,009 --> 01:23:00,878 TRYING TO HELP. WE'LL BE 2156 01:23:00,878 --> 01:23:03,947 PARTNERS WITH THOSE COMMUNITIES. 2157 01:23:03,947 --> 01:23:07,518 RATHER THAN JUST DICTATING FROM 2158 01:23:07,518 --> 01:23:11,121 ABOVE AND WE WILL, WE'LL MAKE 2159 01:23:11,121 --> 01:23:13,991 SURE THAT WE ARE SCRUPULOUSLY 2160 01:23:13,991 --> 01:23:15,693 APOLITICAL, THAT WE'RE FOCUSED 2161 01:23:15,693 --> 01:23:17,494 ON HEALTH NEEDS RATHER THAN ON 2162 01:23:17,494 --> 01:23:18,762 TRYING TO ACHIEVE SOME OTHER 2163 01:23:18,762 --> 01:23:20,164 SOCIAL JUSTICE AIMS. I THINK 2164 01:23:20,164 --> 01:23:22,700 JUST IMPROVING THE HEALTH OF 2165 01:23:22,700 --> 01:23:24,134 POPULATIONS IS ENOUGH. THAT'S 2166 01:23:24,134 --> 01:23:25,703 MORE THAN ENOUGH. IF WE CAN 2167 01:23:25,703 --> 01:23:27,538 ACCOMPLISH THAT, WE'VE DONE WHAT 2168 01:23:27,538 --> 01:23:31,575 WE'RE SUPPOSED TO DO AS THE NIH. 2169 01:23:31,575 --> 01:23:34,478 >> LYNN: THANKS SO MUCH. 2170 01:23:34,478 --> 01:23:36,080 >> WALTER: NEXT IS KATE 2171 01:23:36,080 --> 01:23:38,549 NICHOLSON, BE CAREFUL, KATE'S A 2172 01:23:38,549 --> 01:23:40,384 LAWYER. BE CAREFUL. KATE IS 2173 01:23:40,384 --> 01:23:42,352 THE FOUNDER AND EXECUTIVE 2174 01:23:42,352 --> 01:23:44,788 DIRECTOR OF THE NATIONAL PAIN 2175 01:23:44,788 --> 01:23:45,956 ADVOCACY CENTER AND SHE'S BEEN 2176 01:23:45,956 --> 01:23:50,427 REALLY HELPFUL TO US IN THE HEAL 2177 01:23:50,427 --> 01:23:54,765 INITIATIVE AS WE TRY TO ADVANCE 2178 01:23:54,765 --> 01:24:00,404 THE OPIOID TREATMENT OF PAIN. 2179 01:24:00,404 --> 01:24:09,012 KATE? YOU'RE STILL ON MUTE. 2180 01:24:09,012 --> 01:24:10,781 STILL MUTED. THE BUTTON'S NOT 2181 01:24:10,781 --> 01:24:15,686 WORKING? OKAY. 2182 01:24:15,686 --> 01:24:16,954 >> KATE IF YOU WANT TO E-MAIL 2183 01:24:16,954 --> 01:24:18,388 YOUR QUESTION, WE'LL GO TO THE 2184 01:24:18,388 --> 01:24:20,758 NEXT ONE AND I WILL ASK, OR 2185 01:24:20,758 --> 01:24:22,659 WALTER WILL ASK IT ON YOUR 2186 01:24:22,659 --> 01:24:22,893 BEHALF. 2187 01:24:22,893 --> 01:24:26,730 >> OR YOU CAN PUT IT IN THE CHAT 2188 01:24:26,730 --> 01:24:27,564 >> JAYANTA: I HAVE TIME FOR 2189 01:24:27,564 --> 01:24:29,867 MAYBE TWO MORE QUESTIONS, JUST 2190 01:24:29,867 --> 01:24:32,736 FYI. I CAN GO TO 11:30. 2191 01:24:32,736 --> 01:24:40,444 >> WON'T WE GO TO AMY MCGUIRE'S 2192 01:24:40,444 --> 01:24:44,515 NEXT A BIOETHICIST. WE, IN THE, 2193 01:24:44,515 --> 01:24:45,816 YOU MENTIONED ABOUT SAFE THE I 2194 01:24:45,816 --> 01:24:47,217 WE HAVE A DISCUSSION LATER BUT 2195 01:24:47,217 --> 01:24:49,720 THE BRAIN INITIATIVE IS BROUGHT 2196 01:24:49,720 --> 01:24:53,624 UP SOME NEUROETHICAL PRINCIPLES 2197 01:24:53,624 --> 01:24:56,260 AND ISSUES THAT REALLY ARE QUITE 2198 01:24:56,260 --> 01:24:58,295 STRIKING, NEED TO BE DEALT WITH 2199 01:24:58,295 --> 01:25:02,332 AND AYEMY'S BEEN VERY HELPFUL IN 2200 01:25:02,332 --> 01:25:09,206 THAT SPACE, AYEMY? 2201 01:25:09,206 --> 01:25:10,007 >> JAYA -- 2202 01:25:10,007 --> 01:25:10,674 >> AMY: THANK YOU SO MUCH I WAS 2203 01:25:10,674 --> 01:25:12,176 CURIOUS IF THERE WERE CONCRETE 2204 01:25:12,176 --> 01:25:13,343 WAYS IN WHICH YOU WERE HOPING 2205 01:25:13,343 --> 01:25:16,313 THAT THE NIH COULD PROMOTE THOSE 2206 01:25:16,313 --> 01:25:17,881 PRINCIPLES AND WHETHER YOU HAD 2207 01:25:17,881 --> 01:25:20,951 THOUGHTS ABOUT WHETHER FUNDING 2208 01:25:20,951 --> 01:25:22,419 FOR BIOETHICS RESEARCH MIGHT 2209 01:25:22,419 --> 01:25:23,887 CHANGE UNDER SORT OF THE 2210 01:25:23,887 --> 01:25:26,757 RESTRUCTURING AT THE NIH I MEAN 2211 01:25:26,757 --> 01:25:28,659 IT'S BEEN LARGELY INSTITUTE 2212 01:25:28,659 --> 01:25:29,760 DEPENDENT AS YOU KNOW IN TERMS 2213 01:25:29,760 --> 01:25:31,762 OF WHAT GETS FUNDED AND WHAT 2214 01:25:31,762 --> 01:25:34,731 ISSUES THE ETHICS COMPONENT OF 2215 01:25:34,731 --> 01:25:38,135 IT GETS REAL DEDICATED RESOURCES 2216 01:25:38,135 --> 01:25:40,170 TO ENGAGE WITH AND IT'S LARGELY 2217 01:25:40,170 --> 01:25:42,739 BEEN FOCUSED IN GENOMICS AND THE 2218 01:25:42,739 --> 01:25:44,675 BRAIN INITIATIVE AND A COUPLE 2219 01:25:44,675 --> 01:25:45,909 OTHER INSTITUTES AND I WONDER IF 2220 01:25:45,909 --> 01:25:47,878 THERE'S A THOUGHT ABOUT HOW THAT 2221 01:25:47,878 --> 01:25:50,747 MIGHT LOOK GOING FORWARD? 2222 01:25:50,747 --> 01:25:53,083 >> JAYANTA: SO ON ETHICS, I 2223 01:25:53,083 --> 01:25:54,184 MEAN, IT NEEDS TO BE PART OF ALL 2224 01:25:54,184 --> 01:25:58,222 OUR PORTFOLIO. I MEAN I THINK 2225 01:25:58,222 --> 01:25:59,890 PART OF IT IS THE -- 2226 01:25:59,890 --> 01:26:00,824 REPRODUCIBILITY. I THINK OF IT 2227 01:26:00,824 --> 01:26:05,696 AS AN ETHICAL THING. LIKE IF 2228 01:26:05,696 --> 01:26:06,330 YOU HAVE, THE INCENTIVES WE HAVE 2229 01:26:06,330 --> 01:26:08,699 NOW ARE ALL BROKEN, AMY, WE 2230 01:26:08,699 --> 01:26:10,734 BASICALLY DON'T ENCOURAGE 2231 01:26:10,734 --> 01:26:11,768 PEOPLE, WE BASICALLY ENCOURAGE 2232 01:26:11,768 --> 01:26:14,605 PEOPLE TO CUT CORNERS. BECAUSE 2233 01:26:14,605 --> 01:26:17,741 WE REWARD THEM FOR PUBLICATION 2234 01:26:17,741 --> 01:26:19,376 RATHER THAN FOR DEVELOPING, YOU 2235 01:26:19,376 --> 01:26:21,411 KNOW, TRUE IDEAS, PROSOCIAL 2236 01:26:21,411 --> 01:26:22,746 BEHAVIOR. IF WE CHANGE THAT A 2237 01:26:22,746 --> 01:26:25,716 LOT OF THE ETHICAL PROBLEMS THAT 2238 01:26:25,716 --> 01:26:27,951 HAVE, LIKE, UNDERMINE PUBLIC 2239 01:26:27,951 --> 01:26:28,619 CONFIDENCE SCIENCE WILL START TO 2240 01:26:28,619 --> 01:26:31,421 GO AWAY. OH, I GOT -- I'M 2241 01:26:31,421 --> 01:26:34,758 GETTING PULLED OUT. JUST A 2242 01:26:34,758 --> 01:26:37,461 SECOND. BUT I WANT TO ANSWER 2243 01:26:37,461 --> 01:26:38,896 YOUR QUESTION. THE QUESTION 2244 01:26:38,896 --> 01:26:41,865 ABOUT BIOETHICS, ABSOLUTELY, WE 2245 01:26:41,865 --> 01:26:43,767 ABSOLUTELY NEED TO HAVE 2246 01:26:43,767 --> 01:26:47,237 BIOETHICS BE SUPPORTED AT THE 2247 01:26:47,237 --> 01:26:49,306 NIH. THIS IS NOT A POLICY 2248 01:26:49,306 --> 01:26:50,707 QUESTION. A POLICY THING. I 2249 01:26:50,707 --> 01:26:53,043 WILL TELL YOU MY OWN PERSONAL 2250 01:26:53,043 --> 01:26:54,378 VIEW ON BIOETHICS. I THINK 2251 01:26:54,378 --> 01:26:57,314 THERE'S BEEN A LOT OF BIOETHICS 2252 01:26:57,314 --> 01:26:59,750 THAT HAS ALMOST A PATERNALISTIC 2253 01:26:59,750 --> 01:27:02,419 BEND TO IT THAT I THINK IS PART 2254 01:27:02,419 --> 01:27:05,055 OF YOU KNOW, IT'S NOT ALWAYS 2255 01:27:05,055 --> 01:27:06,757 WRONG. PARENTS SHOULD BE 2256 01:27:06,757 --> 01:27:08,358 PATERNALISTIC TOWARDS THEIR 2257 01:27:08,358 --> 01:27:13,964 KIDS. THAT'S NORMAL. BUT LIKE 2258 01:27:13,964 --> 01:27:18,802 THE BENT OF BIOETHICS, WHERE 2259 01:27:18,802 --> 01:27:22,539 PATERNALISM IS SORT OF... AS 2260 01:27:22,539 --> 01:27:26,576 BUILT INDICT IS A D -- INTO IT 2261 01:27:26,576 --> 01:27:29,146 IS A PROBLEM. 2262 01:27:29,146 --> 01:27:30,514 I THINK EVERYTHING THAT WE DO IF 2263 01:27:30,514 --> 01:27:32,349 IT'S GOING TO TRANSLATE OVER HAS 2264 01:27:32,349 --> 01:27:34,284 TO HAPPEN AT THE COMPONENT AND 2265 01:27:34,284 --> 01:27:35,185 UNDERSTANDING HOW THAT COMPONENT 2266 01:27:35,185 --> 01:27:36,586 WORKS IS GOING TO BE REAL 2267 01:27:36,586 --> 01:27:38,088 IMPORTANT. SO WE WILL SEE. I 2268 01:27:38,088 --> 01:27:39,256 HAVEN'T THOUGHT THROUGH EXACTLY 2269 01:27:39,256 --> 01:27:40,958 WHAT THE POLICY'S GOING TO LOOK 2270 01:27:40,958 --> 01:27:42,592 LIKE. WE WILL SEE IN COMING 2271 01:27:42,592 --> 01:27:44,194 DAYS BUT I APPRECIATE THE 2272 01:27:44,194 --> 01:27:46,763 QUESTION. I AM COMMITTED TO 2273 01:27:46,763 --> 01:27:48,098 MAKING SURE BIOETHICS REMAINS 2274 01:27:48,098 --> 01:27:53,971 PART OF THE NIH PORTFOLIO. 2275 01:27:53,971 --> 01:27:57,474 >> WALTER: AND THE BRAIN IS 2276 01:27:57,474 --> 01:27:58,742 INTEGRATED INTO THE SCIENCE. 2277 01:27:58,742 --> 01:28:00,077 JAY, I WANT TO THANK YOU SO MUCH 2278 01:28:00,077 --> 01:28:02,512 FOR COMING ON AND I THINK 2279 01:28:02,512 --> 01:28:04,081 EVERYONE REALLY APPRECIATES THE 2280 01:28:04,081 --> 01:28:05,282 CANDOR AND THE THOUGHTFULNESS 2281 01:28:05,282 --> 01:28:06,550 AND THE ABILITY TO TAKE THOSE 2282 01:28:06,550 --> 01:28:10,020 QUESTIONS. SO THANKS, HAVE A 2283 01:28:10,020 --> 01:28:11,888 GREAT DAY AND... 2284 01:28:11,888 --> 01:28:12,889 >> JAYANTA: THANKS, EVERYBODY, I 2285 01:28:12,889 --> 01:28:16,093 HAVE TO GO TO THE NEXT MEETING, 2286 01:28:16,093 --> 01:28:18,028 BYE NOW. 2287 01:28:18,028 --> 01:28:18,628 >> WALTER: SORRY ABOUT THAT 2288 01:28:18,628 --> 01:28:29,139 >> JAYANTA: TAKE CARE. BYE. 2289 01:28:30,107 --> 01:28:32,476 >> WALTER DO YOU THINK THERE'S 2290 01:28:32,476 --> 01:28:33,276 AN OPPORTUNITY FOR SOME OF THE 2291 01:28:33,276 --> 01:28:34,745 PEOPLE WHO DIDN'T GET A CHANCE 2292 01:28:34,745 --> 01:28:38,448 TO ASK QUESTION TO HAVE THEIR 2293 01:28:38,448 --> 01:28:44,221 QUESTIONS SENT TO DR. WHAT TA 2294 01:28:44,221 --> 01:28:45,555 CHARIA PERHAPS? 2295 01:28:45,555 --> 01:28:46,456 >> WALTER: IF YOU WANT TO SEND 2296 01:28:46,456 --> 01:28:48,859 THEM TO ME AND I WILL BUNCH THEM 2297 01:28:48,859 --> 01:28:50,894 OVER AND I WILL GET THE ANSWERS 2298 01:28:50,894 --> 01:28:51,828 BACK. 2299 01:28:51,828 --> 01:28:53,296 HE SEEMS INTERESTED IN GETTING 2300 01:28:53,296 --> 01:28:56,833 PEOPLE'S QUESTIONS ANSWERED. 2301 01:28:56,833 --> 01:28:59,936 THAT SOUND OKAY, FRANCES? 2302 01:28:59,936 --> 01:29:01,538 >> FRANCES: THAT SOUNDS 2303 01:29:01,538 --> 01:29:03,206 FANTASTIC AND IT WOULD BE GREAT 2304 01:29:03,206 --> 01:29:05,008 TO SEND THEM TO YOU TO MAKE SURE 2305 01:29:05,008 --> 01:29:08,445 WE CAN ADD TO THEM. THANK YOU. 2306 01:29:08,445 --> 01:29:11,648 >> WALTER: OKAY. ALL RIGHTY SO 2307 01:29:11,648 --> 01:29:14,751 NOW I GUESS THE NEXT THING IS MY 2308 01:29:14,751 --> 01:29:25,295 DIRECTOR'S MESSAGE. OKAY. ALL 2309 01:29:30,901 --> 01:29:35,205 RIGHT, SO AS YOU KNOW, AT NINDS 2310 01:29:35,205 --> 01:29:37,674 WE REALLY TAKEN PRIDE IN BEING 2311 01:29:37,674 --> 01:29:40,844 REALLY TOTALLY TRANSPARENT WITH 2312 01:29:40,844 --> 01:29:43,947 OUR COUNCIL. AND SO AS JAY 2313 01:29:43,947 --> 01:29:48,418 SAID, THERE'S BEEN A LOT OF 2314 01:29:48,418 --> 01:29:53,056 TURBULENCE AND SOME OF THE DOORS 2315 01:29:53,056 --> 01:29:53,924 HAVE COME OFF THE AIRPLANE AND 2316 01:29:53,924 --> 01:29:57,060 SOME OF THE PEOPLE HAVE LEFT THE 2317 01:29:57,060 --> 01:30:00,063 AIRPLANE THROUGH THOSE DOORS 2318 01:30:00,063 --> 01:30:02,799 UNFORTUNATELY. SO THIS IS 2319 01:30:02,799 --> 01:30:05,202 UNLIKE ANYTHING WE'VE PRESENTED 2320 01:30:05,202 --> 01:30:06,069 BEFORE BUT WE'RE GOING TO REALLY 2321 01:30:06,069 --> 01:30:07,737 JUST STICK TO THE FACTS, LET YOU 2322 01:30:07,737 --> 01:30:12,609 KNOW WHAT THE SITUATION IS. AND 2323 01:30:12,609 --> 01:30:14,377 THEN BE CANDID ABOUT SOME OF THE 2324 01:30:14,377 --> 01:30:18,582 UNCERTAINTIES THAT WE'RE LOOKING 2325 01:30:18,582 --> 01:30:24,087 AT. SO START OFF AND END ON A 2326 01:30:24,087 --> 01:30:26,156 HAPPY NOTE. SO NINDS IS AS YOU 2327 01:30:26,156 --> 01:30:29,860 NOW IS TURNING 75 THIS YEAR. 2328 01:30:29,860 --> 01:30:33,730 AND THE ANSWER TO, FOR PEOPLE 2329 01:30:33,730 --> 01:30:35,999 WHO HAVE BEEN INVOLVED IN 2330 01:30:35,999 --> 01:30:37,667 NEUROSCIENCE AND NEUROLOGY FOR 2331 01:30:37,667 --> 01:30:42,405 THE LAST 50-60 YEARS, REALLY 2332 01:30:42,405 --> 01:30:44,875 UNDERSTAND THINKING BACK HOW FAR 2333 01:30:44,875 --> 01:30:46,776 WE'VE COME BUT ALSO HOW FAR WE 2334 01:30:46,776 --> 01:30:50,113 HAVE YET TO GET TO THE GOALS 2335 01:30:50,113 --> 01:30:51,515 OF... THAT WE'RE FOCUSED ON 2336 01:30:51,515 --> 01:30:53,049 WHICH IS ADVANCING OUR 2337 01:30:53,049 --> 01:30:54,017 UNDERSTANDING OF THE BRAIN AND 2338 01:30:54,017 --> 01:30:56,186 THE NERVOUS SYSTEM. AND THEN 2339 01:30:56,186 --> 01:30:58,488 USING THAT KNOWLEDGE TO REDUCE 2340 01:30:58,488 --> 01:31:00,090 THE SUFFERING DUE TO 2341 01:31:00,090 --> 01:31:01,358 NEUROLOGICAL DISORDERS. SO WE 2342 01:31:01,358 --> 01:31:06,196 HAD A LOT OF PLANS FOR THE 75TH 2343 01:31:06,196 --> 01:31:08,865 ANNIVERSARY IN TERMS OF 2344 01:31:08,865 --> 01:31:09,866 CELEBRATION OF PAST EVENTS AND 2345 01:31:09,866 --> 01:31:12,702 THEN LOOKING FORWARD TO THE, YOU 2346 01:31:12,702 --> 01:31:15,238 KNOW, THE PROMISE OF THE FUTURE. 2347 01:31:15,238 --> 01:31:17,574 THOSE WHO ALL GOT CUT SHORT IN 2348 01:31:17,574 --> 01:31:19,476 TERMS OF THE NIH INVOLVEMENT 2349 01:31:19,476 --> 01:31:22,445 BECAUSE OF THE BAN ON TRAVELING, 2350 01:31:22,445 --> 01:31:26,783 THE LOSS OF STAFF AND SUCH, BUT 2351 01:31:26,783 --> 01:31:28,618 REALLY HAPPY THAT WE WERE 2352 01:31:28,618 --> 01:31:30,754 WORKING WITH DIFFERENT 2353 01:31:30,754 --> 01:31:31,588 PROFESSIONAL ORGANIZATIONS AND 2354 01:31:31,588 --> 01:31:34,257 SCIENCE ORGANIZATIONS TO HOLD 2355 01:31:34,257 --> 01:31:35,492 THESE EVENTS AND THEY WERE ABLE 2356 01:31:35,492 --> 01:31:38,762 TO HOLD THEM WITHOUT THE NIH 2357 01:31:38,762 --> 01:31:40,063 FOLKS AND THEY HAVE BEEN I 2358 01:31:40,063 --> 01:31:41,631 THINK, YOU KNOW, I THINK THEY 2359 01:31:41,631 --> 01:31:43,500 REACHED THE GOAL THAT WE HAD IN 2360 01:31:43,500 --> 01:31:46,770 STORE FOR THEM SO THE AMERICAN 2361 01:31:46,770 --> 01:31:48,071 STROKE ASSOCIATION THANKS TO 2362 01:31:48,071 --> 01:31:50,774 THEM THEY HELD A SESSION, THE 2363 01:31:50,774 --> 01:31:52,242 AMERICAN ACADEMY OF NEUROLOGY 2364 01:31:52,242 --> 01:31:56,846 HELD A SESSION ON THE ADVANCES 2365 01:31:56,846 --> 01:31:58,782 COMING OUT OF NINDS RESEARCH. I 2366 01:31:58,782 --> 01:32:00,550 WAS ABLE TO SPEAK AT THE 2367 01:32:00,550 --> 01:32:02,519 AMERICAN ASSOCIATION OF 2368 01:32:02,519 --> 01:32:03,386 NEUROLOGICAL SURGEONS. THE 2369 01:32:03,386 --> 01:32:04,921 TRAVEL BAN IS OVER SO WE'RE 2370 01:32:04,921 --> 01:32:06,723 LOOKING FORWARD TO THE EVENT 2371 01:32:06,723 --> 01:32:08,992 THAT THE AMERICAN NEUROLOGICAL 2372 01:32:08,992 --> 01:32:10,760 ASSOCIATION AND THE SOCIETY FOR 2373 01:32:10,760 --> 01:32:15,398 NEUROSCIENCE COMING UP IN THE 2374 01:32:15,398 --> 01:32:17,567 FALL AND IN THE AMERICAN 2375 01:32:17,567 --> 01:32:20,537 EPILEPSY SOCIETY IN THE LATE 2376 01:32:20,537 --> 01:32:24,608 FALL. THE LEADERSHIP CHANGES I 2377 01:32:24,608 --> 01:32:27,043 THINK THAT JAY TALKED ABOUT 2378 01:32:27,043 --> 01:32:28,878 THOSE. I WILL SKIP THROUGH 2379 01:32:28,878 --> 01:32:32,449 THERE. THE LEADERSHIP CHANGES. 2380 01:32:32,449 --> 01:32:36,920 HE ALSO MENTIONED. COUPLE 2381 01:32:36,920 --> 01:32:38,788 OTHERS, JOHN WHO IS DIRECTOR OF 2382 01:32:38,788 --> 01:32:40,290 THE NATIONAL INSTITUTE OF 2383 01:32:40,290 --> 01:32:42,759 MEDICAL SERVICES IS NOW THE 2384 01:32:42,759 --> 01:32:44,327 ACTING DEPUTY DIRECTOR FOR THE 2385 01:32:44,327 --> 01:32:46,763 OFFICE OF EXTRAMURAL RESEARCH. 2386 01:32:46,763 --> 01:32:50,467 AND THE OFFICE OF EXTRAMURAL 2387 01:32:50,467 --> 01:32:51,935 RESEARCH IS THE KIND OF THE CORE 2388 01:32:51,935 --> 01:32:54,738 PART OF NIH THAT ESTABLISHES 2389 01:32:54,738 --> 01:32:57,140 POLICIES AND IMPLEMENTS POLICIES 2390 01:32:57,140 --> 01:33:00,944 THAT COME DOWN FROM HHS WITH 2391 01:33:00,944 --> 01:33:03,847 REGARD TO RESEARCH AND WHAT WE, 2392 01:33:03,847 --> 01:33:08,451 YOU KNOW, HOW WE DO OUR GRANT 2393 01:33:08,451 --> 01:33:09,252 MECHANISMS AND WE'LL TALK ABOUT 2394 01:33:09,252 --> 01:33:13,023 NOTICE OF FUNDING AWARDS AND 2395 01:33:13,023 --> 01:33:17,727 THINGS LIKE THAT. THE CALL CAME 2396 01:33:17,727 --> 01:33:21,765 FROM NIHS AND RUNS THE PROGRAM 2397 01:33:21,765 --> 01:33:26,102 COORDINATION OFFICE IN DOCTOR 2398 01:33:26,102 --> 01:33:26,703 THE OFFICE OF THE DIRECTOR. 2399 01:33:26,703 --> 01:33:28,371 RESPONSIBLE FOR THINGS LIKE THE 2400 01:33:28,371 --> 01:33:30,774 COMMON FUND AND ALSO TAKING A 2401 01:33:30,774 --> 01:33:34,377 STRONG ROLE IN THE AUTISM 2402 01:33:34,377 --> 01:33:38,381 PROJECT THAT DR. BHATTACHARYA 2403 01:33:38,381 --> 01:33:41,318 MENTIONED. SCENE THAT KRAN STON 2404 01:33:41,318 --> 01:33:43,787 CAME OVER AS THE NIH CHIEF OF 2405 01:33:43,787 --> 01:33:45,789 STAFF AND WAS PREVIOUSLY ON THE 2406 01:33:45,789 --> 01:33:51,961 STAFF OF FOLKS IN THE SENATE. 2407 01:33:51,961 --> 01:33:56,032 IN TERMS OF ICD LEADERSHIP, 2408 01:33:56,032 --> 01:33:58,034 UNFORTUNATELY, A NUMBER OF 2409 01:33:58,034 --> 01:34:00,503 INSTITUTE DIRECTORS WERE LET GO. 2410 01:34:00,503 --> 01:34:02,439 AND SO THERE ARE ACTING 2411 01:34:02,439 --> 01:34:05,508 DIRECTORS THERE WHO STEPPED UP, 2412 01:34:05,508 --> 01:34:07,110 COURTNEY AC LAND WHO USED TO BE 2413 01:34:07,110 --> 01:34:13,016 HERE IS ACTING AT THE NURSING 2414 01:34:13,016 --> 01:34:15,885 INSTITUTE. ALISON CERNICH WAS 2415 01:34:15,885 --> 01:34:18,021 THE DEPUTY AND NOW AT THE 2416 01:34:18,021 --> 01:34:18,788 NATIONAL INSTITUTE ON CHILD 2417 01:34:18,788 --> 01:34:20,790 HEALTH AND HUMAN DEVELOPMENT. 2418 01:34:20,790 --> 01:34:24,060 MONICA WEB HOOPER, ANDREA BECK 2419 01:34:24,060 --> 01:34:26,996 L-MITCH NEVER IS, SO, AS YOU 2420 01:34:26,996 --> 01:34:30,333 REMEMBER JOSH GORDON MOVED BACK 2421 01:34:30,333 --> 01:34:33,703 TO COLUMBIA. SHELLY WAS THE 2422 01:34:33,703 --> 01:34:36,473 ACTING DIRECTOR. SHE RETIRED 2423 01:34:36,473 --> 01:34:38,775 AND ANDREA BECK L MITCH NEVER IS 2424 01:34:38,775 --> 01:34:42,779 NOW THE ACTING DIRECTOR AT NIH. 2425 01:34:42,779 --> 01:34:45,749 ANDREA IS FANTASTIC AND HAS BEEN 2426 01:34:45,749 --> 01:34:47,350 THE DEPUTY DIRECTOR FOR THE 2427 01:34:47,350 --> 01:34:49,452 BRAIN INITIATIVE AND SO SHE'S 2428 01:34:49,452 --> 01:34:54,057 NOW TAKEN, SHE'S GOT NOW TWO 2429 01:34:54,057 --> 01:34:58,762 FULL-TIME JOBS, CAROLYN HUTTER 2430 01:34:58,762 --> 01:35:06,403 IS NOW THE ACTING DIRECTOR AT 2431 01:35:06,403 --> 01:35:06,936 THE NATIONAL HUMAN GENOME 2432 01:35:06,936 --> 01:35:08,671 INSTITUTE AND JEFF CAME TO BE 2433 01:35:08,671 --> 01:35:16,513 THE ACTING DIRECTOR OF NIAI DD 2434 01:35:16,513 --> 01:35:20,350 WE HAD A NUMBER OF PEOPLE WHO I 2435 01:35:20,350 --> 01:35:22,886 THINK TOOK ADVANTAGE OF THE 2436 01:35:22,886 --> 01:35:25,922 ABILITY TO RETIRE FROM FEDERAL 2437 01:35:25,922 --> 01:35:27,257 SERVICE. THAT WAS OFFERED BY 2438 01:35:27,257 --> 01:35:31,895 THE EXECUTIVE BRANCH. I THINK A 2439 01:35:31,895 --> 01:35:34,364 NUMBER OF THEM WAS IN THEIR 2440 01:35:34,364 --> 01:35:35,632 PLANS. SOME OF THEM WERE GOING 2441 01:35:35,632 --> 01:35:40,203 TO RETIRE IN ANY EVENT. ROD WHO 2442 01:35:40,203 --> 01:35:42,439 LED THE DEMENTIA PROGRAM HAS 2443 01:35:42,439 --> 01:35:45,341 LEFT AND RETIRED. LYNN JAKEMAN 2444 01:35:45,341 --> 01:35:48,411 WHO WAS THE DIRECTOR OF DIVISION 2445 01:35:48,411 --> 01:35:51,781 OF NEUROSCIENCE IS RETIRED. 2446 01:35:51,781 --> 01:35:53,883 MICHELE JONES-LONDON WHO WAS 2447 01:35:53,883 --> 01:35:55,685 JUST A FORCE OF NATURE AND 2448 01:35:55,685 --> 01:35:58,321 IMPROVING THE DIVERSITY OF OUR 2449 01:35:58,321 --> 01:35:58,621 WORKFORCE. 2450 01:35:58,621 --> 01:36:00,790 AND BASICALLY IMPROVING OUR 2451 01:36:00,790 --> 01:36:02,759 WORKFORCE AND INSTITUTE IN 2452 01:36:02,759 --> 01:36:06,463 GENERAL IS RETIRED. STEVE KORN 2453 01:36:06,463 --> 01:36:07,797 A LONG TIME DIRECTOR OF OUR 2454 01:36:07,797 --> 01:36:11,301 TRAINING OFFICE IS RETIRED. 2455 01:36:11,301 --> 01:36:13,670 ERNIE LYONS, WE'LL GET TO WHAT 2456 01:36:13,670 --> 01:36:16,506 HAPPENS WITH REVIEW BRANCH IN A 2457 01:36:16,506 --> 01:36:19,242 SECOND. DAVE OWENS WHO WAS THE 2458 01:36:19,242 --> 01:36:22,779 DEPUTY DIRECTOR FOR DIVISION OF 2459 01:36:22,779 --> 01:36:23,513 EXTRAMURAL ACTIVITIES AND ACTING 2460 01:36:23,513 --> 01:36:26,049 DIRECTOR RETIRED. LINDA PORTER 2461 01:36:26,049 --> 01:36:30,787 WHO WAS THE FORCE BEHIND ALL OUR 2462 01:36:30,787 --> 01:36:34,390 PAIN INITIATIVES HERE AT NINDS 2463 01:36:34,390 --> 01:36:39,195 FOR YEARS PAIN CONSORTIUM, THE 2464 01:36:39,195 --> 01:36:42,632 INTERAGENCY PAIN COORDINATING 2465 01:36:42,632 --> 01:36:45,168 COMMITTEE AND THE HEAL 2466 01:36:45,168 --> 01:36:46,769 INITIATIVE RETIRED AND MARY ANN 2467 01:36:46,769 --> 01:36:49,038 SEW FRANCO WHO MANY OF YOU HAVE 2468 01:36:49,038 --> 01:36:52,208 NOT MET BUT WAS A FORCE AS THE 2469 01:36:52,208 --> 01:36:55,445 EXECUTIVE OFFICER. SO WE DID 2470 01:36:55,445 --> 01:37:05,989 LOSE REALLY HIGHLY CONTRIBU 2471 01:37:41,357 --> 01:37:43,960 CONTRIBUTING... PAT WHO WAS THE 2472 01:37:43,960 --> 01:37:46,095 DEPUTY TO LYNN JAKEMAN IS KNOT 2473 01:37:46,095 --> 01:37:50,166 NOW THE ACTING DIRECTOR OF THE 2474 01:37:50,166 --> 01:37:55,138 DIVISION OF NEUROSCIENCE AND 2475 01:37:55,138 --> 01:37:55,838 TISCH WHO WE WANT OUT TO 2476 01:37:55,838 --> 01:37:59,442 INDUSTRY AND CAME BACK IS KNOW 2477 01:37:59,442 --> 01:38:05,014 THE DIRECTOR OF OUR TRAINING. 2478 01:38:05,014 --> 01:38:06,416 WE HAVE GREAT PEOPLE WHO 2479 01:38:06,416 --> 01:38:08,785 ACCEPTED IN. TROUBLE IS THEY'RE 2480 01:38:08,785 --> 01:38:10,386 DOING MORE THAN ONE PERSON'S JOB 2481 01:38:10,386 --> 01:38:11,988 AND THAT IS ACTUALLY TRUE ACROSS 2482 01:38:11,988 --> 01:38:18,795 THE INSTITUTE IN GENERAL. SO 2483 01:38:18,795 --> 01:38:22,098 THE CHALLENGE IS, YOU KNOW, 2484 01:38:22,098 --> 01:38:24,067 PRETTY CLEAR AS WAS MENTIONED 2485 01:38:24,067 --> 01:38:26,469 REDUCTION, WE'VE LOST ABOUT 143 2486 01:38:26,469 --> 01:38:30,807 STAFF FOLKS. THIS HAS BEEN 2487 01:38:30,807 --> 01:38:33,810 ALMOST ENTIRELY, NOT TOTALLY BUT 2488 01:38:33,810 --> 01:38:35,845 ALMOST ENTIRELY IN THE 2489 01:38:35,845 --> 01:38:40,183 EXTRAMURAL WORLD WHERE, AND THE 2490 01:38:40,183 --> 01:38:41,584 OFFICE OF THE DIRECTOR WHERE WE 2491 01:38:41,584 --> 01:38:45,888 WORK ON THE GETTING GRANTS OUT 2492 01:38:45,888 --> 01:38:49,726 TO ADVANCING OUR SCIENCE. 90% 2493 01:38:49,726 --> 01:38:53,930 OF OUR FUNDS GO OUT THROUGH THE 2494 01:38:53,930 --> 01:38:57,200 DIVISION OF EXTRAMURAL RESEARCH 2495 01:38:57,200 --> 01:39:01,104 AND THE OFFICE OF DIRECTOR IS 2496 01:39:01,104 --> 01:39:03,039 RESPONSIBLE FOR MANAGING HOW WE 2497 01:39:03,039 --> 01:39:06,809 DO THAT AND SO WE LOST ABOUT 143 2498 01:39:06,809 --> 01:39:09,712 OUT OF, I WAS GOING TO SAY ABOUT 2499 01:39:09,712 --> 01:39:12,315 150 PEOPLE, MAYBE, WOULD THAT BE 2500 01:39:12,315 --> 01:39:16,786 FAIR? 143 OUT OF 150 PEOPLE 2501 01:39:16,786 --> 01:39:17,654 WHAT THAT MEANS IS WE REALLY 2502 01:39:17,654 --> 01:39:19,756 HAVE TO FOCUS DOWN ON OUR CORE 2503 01:39:19,756 --> 01:39:21,658 ACTIVITIES AND WE ARE NOT GOING 2504 01:39:21,658 --> 01:39:22,525 TO BE ABLE TO DO A LOT OF THE 2505 01:39:22,525 --> 01:39:25,161 OTHER THINGS THAT WE THINK ARE 2506 01:39:25,161 --> 01:39:27,830 REALLY IMPORTANT BUT JUST HAVE 2507 01:39:27,830 --> 01:39:34,303 TO BE POSTPONED UNTIL WE GET TO 2508 01:39:34,303 --> 01:39:36,606 A BETTER STATE. NOW MOST, WHAT, 2509 01:39:36,606 --> 01:39:38,775 THE WAY IN WHICH THE REDUCTION 2510 01:39:38,775 --> 01:39:42,779 IN FORCE WORKS IN THE GOVERNMENT 2511 01:39:42,779 --> 01:39:45,181 IT'S KIND OF INSIDE BASEBALL BUT 2512 01:39:45,181 --> 01:39:47,884 PEOPLE WHO ARE IN THE GOVERNMENT 2513 01:39:47,884 --> 01:39:50,453 ARE, HAVE CIVIL SERVICE 2514 01:39:50,453 --> 01:39:53,756 PROTECTION SO FOR THEM TO BE LET 2515 01:39:53,756 --> 01:39:56,826 GO IT HAS TO BE SOMETHING 2516 01:39:56,826 --> 01:39:58,227 EGREGIOUS THAT HAS HAPPENED OR 2517 01:39:58,227 --> 01:39:59,262 THEY HAVE TO BE REALLY FAILING 2518 01:39:59,262 --> 01:40:01,364 IN THEIR WORK. THE EXCEPTION TO 2519 01:40:01,364 --> 01:40:02,765 THAT ARE PEOPLE WHO HAVE BEEN 2520 01:40:02,765 --> 01:40:05,101 HIRED WITHIN THE FIRST YEAR SO 2521 01:40:05,101 --> 01:40:08,871 THEY ARE ON WHAT'S CALLED 2522 01:40:08,871 --> 01:40:11,140 PROBATION FOR THE FIRST YEAR AND 2523 01:40:11,140 --> 01:40:14,243 WE HIRED A LARGE NUMBER OF 2524 01:40:14,243 --> 01:40:15,912 PEOPLE IN THE LAST YEAR AND ALL 2525 01:40:15,912 --> 01:40:19,148 THOSE PEOPLE WERE LET GO PRETTY 2526 01:40:19,148 --> 01:40:22,785 MUCH. AND THEY WERE DOING 2527 01:40:22,785 --> 01:40:23,453 TREMENDOUS WORK FOR INSTANCE THE 2528 01:40:23,453 --> 01:40:27,590 WORKING AS PROGRAM ANALYSTS ON 2529 01:40:27,590 --> 01:40:30,493 THE DIFFERENT SCIENCE PROJECTS. 2530 01:40:30,493 --> 01:40:32,028 IN THE OFFICE OF DIRECTOR. 2531 01:40:32,028 --> 01:40:33,062 THESE ARE THE PEOPLE THAT WERE 2532 01:40:33,062 --> 01:40:36,799 THE FUTURE OF NINDS AND VERY 2533 01:40:36,799 --> 01:40:40,169 TALENTED FOLKS THAT WE LOST 2534 01:40:40,169 --> 01:40:40,937 THERE. THEN THERE WAS WHAT'S 2535 01:40:40,937 --> 01:40:44,507 CALLED THE REDUCTION IN FORCE SO 2536 01:40:44,507 --> 01:40:46,075 WHEN THE GOVERNMENT, ALTHOUGH 2537 01:40:46,075 --> 01:40:47,877 YOU CAN'T THROW AROUND AND FIRE 2538 01:40:47,877 --> 01:40:49,412 INDIVIDUAL PEOPLE IF YOU WANT TO 2539 01:40:49,412 --> 01:40:51,114 REDUCE YOUR NUMBERS, BUT WHAT 2540 01:40:51,114 --> 01:40:52,982 YOU CAN DO IS YOU CAN GO IN AND 2541 01:40:52,982 --> 01:40:55,017 CLOSE AN ENTIRE OFFICE. SO THAT 2542 01:40:55,017 --> 01:40:57,920 IS WHAT HAPPENED AND THEY WENT 2543 01:40:57,920 --> 01:41:00,623 IN TO OFFICES ACROSS NIH ON THE 2544 01:41:00,623 --> 01:41:02,291 EXTRAMURAL AND OFFICE OF 2545 01:41:02,291 --> 01:41:05,828 DIRECTOR SIDE SO WE HAD A 2546 01:41:05,828 --> 01:41:08,297 LEGISLATIVE OFFICE AND POLICY 2547 01:41:08,297 --> 01:41:10,333 OFFICE AND ALL THOSE PEOPLE WERE 2548 01:41:10,333 --> 01:41:13,136 LET GO. OFFICE OF PAIN POLICY 2549 01:41:13,136 --> 01:41:18,141 AND PLANNING WHICH WAS LINDA 2550 01:41:18,141 --> 01:41:19,942 PORTER WAS RUNNING. WHAT, YOU 2551 01:41:19,942 --> 01:41:22,211 KNOW, IT STARTED AS A POLICY 2552 01:41:22,211 --> 01:41:22,979 OFFICE BUT WHAT HAPPENED WITH 2553 01:41:22,979 --> 01:41:27,617 THE HEAL INITIATIVE WAS A LOT OF 2554 01:41:27,617 --> 01:41:28,718 THE HEAL INITIATIVE ACTIVITIES 2555 01:41:28,718 --> 01:41:30,686 INCLUDING OVER SIGHT OF GRANTS 2556 01:41:30,686 --> 01:41:32,421 AND TRAINING WERE IN THE OFFICE 2557 01:41:32,421 --> 01:41:34,791 OF PAIN POLICY AND THE OFFICE OF 2558 01:41:34,791 --> 01:41:39,195 DIRECTOR AND ALL OF THOSE PEOPLE 2559 01:41:39,195 --> 01:41:40,329 WERE LET GO. THE MANAGEMENT 2560 01:41:40,329 --> 01:41:43,866 TEAM FOR THINGS THAT, YOU KNOW, 2561 01:41:43,866 --> 01:41:46,135 YOU, IF YOU'RE IN AN 2562 01:41:46,135 --> 01:41:46,669 ORGANIZATION ARE REALLY 2563 01:41:46,669 --> 01:41:49,972 ESSENTIAL TO HAPPEN ON A 2564 01:41:49,972 --> 01:41:52,942 DAY-TO-DAY BASIS. THOSE FOLKS 2565 01:41:52,942 --> 01:41:54,644 ARE NOW GONE. BIG PROBLEM NOW 2566 01:41:54,644 --> 01:41:57,446 IS IN, WHAT'S CALLED 2567 01:41:57,446 --> 01:41:58,781 ACQUISITIONS WHICH IS THE PEOPLE 2568 01:41:58,781 --> 01:42:01,150 WHO DO THE CONTRACTS IN THE 2569 01:42:01,150 --> 01:42:02,785 GOVERNMENT. IT'S A HIGHLY 2570 01:42:02,785 --> 01:42:06,255 SKILLED AREA. YOU HAVE TO HAVE 2571 01:42:06,255 --> 01:42:08,357 A SPECIAL WARRANT TO BE ABLE TO 2572 01:42:08,357 --> 01:42:10,660 DO THAT. IT TAKES ABOUT THREE 2573 01:42:10,660 --> 01:42:12,929 YEARS TO BE A COAG FOR CONTRACTS 2574 01:42:12,929 --> 01:42:14,230 AND THOSE PEOPLE ARE GONE. SO 2575 01:42:14,230 --> 01:42:16,065 WE HAVE A NUMBER OF CONTRACTS 2576 01:42:16,065 --> 01:42:18,100 WE'RE NOT SURE HOW WE'RE GOING 2577 01:42:18,100 --> 01:42:20,803 TO EXECUTE THEM AND NEW 2578 01:42:20,803 --> 01:42:22,271 CONTRACTS ARE GOING TO BE 2579 01:42:22,271 --> 01:42:25,875 EXTREMELY DIFFICULT. WE HAVE AN 2580 01:42:25,875 --> 01:42:27,977 ETHICS GROUP WHO THE PEOPLE HERE 2581 01:42:27,977 --> 01:42:30,279 ON THE COUNCIL HAVE MET BECAUSE 2582 01:42:30,279 --> 01:42:34,050 EVERYONE IN THE GOVERNMENT 2583 01:42:34,050 --> 01:42:34,784 INCLUDING SPECIAL GOVERNMENT 2584 01:42:34,784 --> 01:42:36,919 EMPLOYEES HAVE TO GO THROUGH 2585 01:42:36,919 --> 01:42:38,788 THIS ETHICS REVIEW. THE ETHICS 2586 01:42:38,788 --> 01:42:40,223 PEOPLE ARE ALL GONE NOW. SO A 2587 01:42:40,223 --> 01:42:42,191 LOT OF THE THINGS THAT WE USED 2588 01:42:42,191 --> 01:42:43,926 TO DO THAT WERE KIND OF LIKE A 2589 01:42:43,926 --> 01:42:47,563 MACHINES WITHIN THE INSTITUTE 2590 01:42:47,563 --> 01:42:51,234 HAVE NOW BEEN DISENTANGLED AND 2591 01:42:51,234 --> 01:42:54,437 MOVED. THE IDEA OVER HERE IS 2592 01:42:54,437 --> 01:42:59,809 THAT SOME OF THESE FUNCTIONS 2593 01:42:59,809 --> 01:43:00,743 WERE INEFFICIENT BECAUSE THEY 2594 01:43:00,743 --> 01:43:02,078 WERE ALL DOING THE SAME THING. 2595 01:43:02,078 --> 01:43:03,880 THE PROBLEM IS THAT DOESN'T 2596 01:43:03,880 --> 01:43:06,148 HAPPEN YET AND IT'S NOT ENTIRELY 2597 01:43:06,148 --> 01:43:07,783 CLEAR HOW CENTRALIZATION IS 2598 01:43:07,783 --> 01:43:08,918 GOING TO BE MORE EFFICIENT. BUT 2599 01:43:08,918 --> 01:43:11,787 THAT'S WHAT WE'RE WAITING ON 2600 01:43:11,787 --> 01:43:14,757 NOW. IS CENTRALIZATION OF THESE 2601 01:43:14,757 --> 01:43:17,760 TYPE OF ACTIVITIES. INTRAMURAL, 2602 01:43:17,760 --> 01:43:19,362 YOU MAY HAVE READ IN THE PAPER 2603 01:43:19,362 --> 01:43:24,233 THAT WE HAD TEN OF OUR SENIOR 2604 01:43:24,233 --> 01:43:26,202 SCIENTISTS WHO WERE FIRED UNDER 2605 01:43:26,202 --> 01:43:28,905 THE REDUCTION FORCE AND THE 2606 01:43:28,905 --> 01:43:30,406 REASON IS BECAUSE AS OPPOSED TO 2607 01:43:30,406 --> 01:43:35,077 MANY OTHER INSTITUTES, OUR 2608 01:43:35,077 --> 01:43:38,514 INVESTIGATORS WHO RUN 2609 01:43:38,514 --> 01:43:40,483 LABORATORIES ARE NOT PART ANY 2610 01:43:40,483 --> 01:43:41,584 HIERARCHY SO THEY'RE NOT PART OF 2611 01:43:41,584 --> 01:43:45,021 A LAB OR A LAB CHIEF. THEY'RE 2612 01:43:45,021 --> 01:43:46,155 INDEPENDENT AND SO THEY REPORTED 2613 01:43:46,155 --> 01:43:48,357 TO THE SCIENTIFIC DIRECTOR SO 2614 01:43:48,357 --> 01:43:50,359 THEY WERE TAGGED AS BEING 2615 01:43:50,359 --> 01:43:53,529 MEMBERS OF THE OFFICE OF THE 2616 01:43:53,529 --> 01:43:57,600 SCIENTIFIC DIRECTOR AND THE 2617 01:43:57,600 --> 01:43:59,435 WHOLE OFFICE WAS FIRED NOT 2618 01:43:59,435 --> 01:44:01,270 REALIZING THEY THOUGHT THE IDEA 2619 01:44:01,270 --> 01:44:03,706 WAS THAT THESE PEOPLE WERE 2620 01:44:03,706 --> 01:44:05,474 ADMINISTRATIVE PEOPLE AND NOT 2621 01:44:05,474 --> 01:44:06,776 THE SCIENTISTS NOW WE HAVE 2622 01:44:06,776 --> 01:44:09,612 GOTTEN ASSURANCES FROM DR. BAT 2623 01:44:09,612 --> 01:44:12,081 TA CHAR YA AND ANY OTHER PERSON 2624 01:44:12,081 --> 01:44:13,816 WE'VE BEEN ABLE TO TALK TO THAT 2625 01:44:13,816 --> 01:44:17,420 THESE FOLKS THE SENIOR 2626 01:44:17,420 --> 01:44:18,087 INVESTIGATORS WILL BE, THEY HAVE 2627 01:44:18,087 --> 01:44:19,155 BEEN RETURNED TO THEIR WORK. 2628 01:44:19,155 --> 01:44:21,557 SO THEY ARE AT WORK. AND WE 2629 01:44:21,557 --> 01:44:23,259 HAVE RECEIVED ALL ASSURANCES 2630 01:44:23,259 --> 01:44:26,762 THAT THEY'RE GOING TO BE 2631 01:44:26,762 --> 01:44:27,697 REINSTATED. AND OF COURSE IT'S 2632 01:44:27,697 --> 01:44:30,766 NOT JUST THE TEN INVESTIGATORS 2633 01:44:30,766 --> 01:44:34,203 BUT IN TOTAL IT'S 115 PEOPLE IN 2634 01:44:34,203 --> 01:44:37,073 THE LABORATORIES THAT WOULD BE 2635 01:44:37,073 --> 01:44:38,841 AFFECTED. SO THAT SHOULD HAPPEN 2636 01:44:38,841 --> 01:44:41,544 BY JUNE 2ND. AND I THINK WE'VE 2637 01:44:41,544 --> 01:44:44,847 GOTTEN SOME REALLY GOOD STRONG 2638 01:44:44,847 --> 01:44:47,583 ASSURANCES AT WILL. SO THE 2639 01:44:47,583 --> 01:44:48,951 CHALLENGE IS THAT LISTED HERE WE 2640 01:44:48,951 --> 01:44:53,022 HAD A PAUSE IN ABILITY TO, YOU 2641 01:44:53,022 --> 01:44:54,824 KNOW, MAKE PURCHASES WHICH 2642 01:44:54,824 --> 01:44:56,058 REALLY HURT THE INTRAMURAL 2643 01:44:56,058 --> 01:44:58,761 PEOPLE AS WELL AS THE EXTRAMURAL 2644 01:44:58,761 --> 01:44:59,996 BUT CERTAINLY INTRAMURAL THEY 2645 01:44:59,996 --> 01:45:02,832 WEREN'T ABLE TO ORDER SUPPLIES 2646 01:45:02,832 --> 01:45:04,834 TO DO THEIR EXPERIMENTS. THEIR 2647 01:45:04,834 --> 01:45:06,369 EXPERIMENTS WERE SUPPOSEDLY ON 2648 01:45:06,369 --> 01:45:08,104 HOLD YOU CAN ONLY DO EXPERIMENTS 2649 01:45:08,104 --> 01:45:09,905 THAT WERE STARTED OR SCIENCE 2650 01:45:09,905 --> 01:45:11,807 THAT WAS STARTED BEFORE THE NEW 2651 01:45:11,807 --> 01:45:13,309 ADMINISTRATION. THAT'S ALL GONE 2652 01:45:13,309 --> 01:45:15,811 NOW. THAT'S FINE TO GO. TRAVEL 2653 01:45:15,811 --> 01:45:20,483 WAS ON HOLD NOW TRAVEL IS OPEN 2654 01:45:20,483 --> 01:45:22,051 AGAIN. COMMUNICATIONS ARE NOW 2655 01:45:22,051 --> 01:45:24,820 OPEN AGAIN EXCEPT WE DON'T HAVE 2656 01:45:24,820 --> 01:45:26,689 THE COMMUNICATIONS GROUP THAT WE 2657 01:45:26,689 --> 01:45:28,791 HAD SO OUR ABILITY TO DO THINGS 2658 01:45:28,791 --> 01:45:31,227 SAY ON THE WEBSITE, OUR ABILITY 2659 01:45:31,227 --> 01:45:33,029 TO DO MEETINGS IS REALLY ALMOST 2660 01:45:33,029 --> 01:45:35,865 IMPOSSIBLE FOR US TO DO MEETINGS 2661 01:45:35,865 --> 01:45:38,768 NOW. YOU WOULD HAVE TO HAVE OUR 2662 01:45:38,768 --> 01:45:42,138 PROGRAM DIRECTORS BASICALLY SET 2663 01:45:42,138 --> 01:45:44,040 UP HOTELS AND AIRPLANE FLIGHTS 2664 01:45:44,040 --> 01:45:45,975 FOR PEOPLE AND REGISTER. SO A 2665 01:45:45,975 --> 01:45:49,211 LOT OF THINGS WE CAN'T DO. AS 2666 01:45:49,211 --> 01:45:50,946 YOU KNOW THE COUNCILS WERE 2667 01:45:50,946 --> 01:45:54,083 PAUSED THIS IS OUR FIRST OPEN 2668 01:45:54,083 --> 01:45:58,020 SESSION OF THE YEAR. BIG 2669 01:45:58,020 --> 01:45:59,522 PROBLEM FOR US IS THAT IT'S 2670 01:45:59,522 --> 01:46:02,525 THOUGHT THAT THE REVIEWS OF 2671 01:46:02,525 --> 01:46:04,593 GRANTS THAT WERE BEING DONE IN 2672 01:46:04,593 --> 01:46:08,130 THE INSTITUTE WERE BIASED: AND 2673 01:46:08,130 --> 01:46:10,066 SO THE ADMINISTRATION IS 2674 01:46:10,066 --> 01:46:13,135 PREVENTING ANYMORE REVIEW IN THE 2675 01:46:13,135 --> 01:46:14,003 INSTITUTE'S STUDY SECTIONS AND 2676 01:46:14,003 --> 01:46:17,006 EVERYTHING IS GOING TO BE 2677 01:46:17,006 --> 01:46:23,846 REVIEWED AT THE CSR WHICH IS THE 2678 01:46:23,846 --> 01:46:26,015 CENTRALIZED REVIEW GROUP 2679 01:46:26,015 --> 01:46:26,782 INSTITUTE. BASICALLY A CENTER 2680 01:46:26,782 --> 01:46:29,218 FOR SCIENTIFIC REVIEW. THAT'S 2681 01:46:29,218 --> 01:46:31,520 SEPARATE FROM ANY OF THE 2682 01:46:31,520 --> 01:46:33,055 INSTITUTES AND I THINK IT'LL 2683 01:46:33,055 --> 01:46:36,992 TAKE A LITTLE BIT OF TIME FOR 2684 01:46:36,992 --> 01:46:38,794 CSR TO BE ABLE TO WORK WITH THE 2685 01:46:38,794 --> 01:46:43,065 TYPE OF PROJECTS THAT ARE KIND 2686 01:46:43,065 --> 01:46:46,102 OF MORE I THINK AS ANDY SAID, 2687 01:46:46,102 --> 01:46:48,704 MORE SPECIALIZED IN A PARTICULAR 2688 01:46:48,704 --> 01:46:50,306 AREA WHERE THERE ARE THINGS 2689 01:46:50,306 --> 01:46:52,241 WE'RE REALLY WANTED TO GET OUT 2690 01:46:52,241 --> 01:46:54,777 OF THE REVIEW AND THE CALL FOR 2691 01:46:54,777 --> 01:46:57,680 APPLICATIONS. WE'LL TALK A 2692 01:46:57,680 --> 01:46:58,747 LITTLE BIT ABOUT THAT AND IT'S 2693 01:46:58,747 --> 01:47:02,284 RELATED TO WHAT ANDY MENTIONED 2694 01:47:02,284 --> 01:47:03,252 WHICH IS THAT THE ADMINISTRATION 2695 01:47:03,252 --> 01:47:06,088 IS LOOKING FOR US TO REDUCE THE 2696 01:47:06,088 --> 01:47:10,292 NUMBER OF RFAS NOW CALLED NOTICE 2697 01:47:10,292 --> 01:47:12,661 OF FUNDING ANNOUNCEMENTS BY 50% 2698 01:47:12,661 --> 01:47:14,563 AND THEY REALLY WANT US TO USE 2699 01:47:14,563 --> 01:47:18,400 THE PARENT AWARDS MORE THAN 2700 01:47:18,400 --> 01:47:20,469 THE... RELYING ON RFAS. I THINK 2701 01:47:20,469 --> 01:47:22,271 WE CAN WORK ON WAYS TO DO THAT. 2702 01:47:22,271 --> 01:47:26,375 BUT IT'S GOING TO REQUIRE 2703 01:47:26,375 --> 01:47:30,079 COMMUNICATION BY US OUT TO THE 2704 01:47:30,079 --> 01:47:32,848 GRANTEES TO GIVE THEM AN 2705 01:47:32,848 --> 01:47:35,484 INDICATION OF, YOU KNOW, IN THIS 2706 01:47:35,484 --> 01:47:36,986 COUNTS COMING UP IN SEPTEMBER 2707 01:47:36,986 --> 01:47:38,187 COUNCIL WE'RE GOING TO BE 2708 01:47:38,187 --> 01:47:39,588 FUNDING GRANTS IN THIS AREA SO 2709 01:47:39,588 --> 01:47:41,390 IF YOU HAVE GOOD IDEAS IN THIS 2710 01:47:41,390 --> 01:47:43,893 AREA PLEASE SUBMIT GRANTS BY, 2711 01:47:43,893 --> 01:47:48,764 YOU KNOW, FEBRUARY OF THE... 2712 01:47:48,764 --> 01:47:51,066 FEBRUARY BEFORE THE COUNCIL. TO 2713 01:47:51,066 --> 01:47:52,234 GIVE PEOPLE AN IDEA OF WHAT 2714 01:47:52,234 --> 01:47:53,636 WE'RE LOOKING FOR IN TERMS OF 2715 01:47:53,636 --> 01:47:58,140 THE SCIENCE, WHEN TO APPLY, AND 2716 01:47:58,140 --> 01:47:59,542 WHEN... SO THAT ALL THOSE KIND 2717 01:47:59,542 --> 01:48:01,443 OF GRANTS CAN BE COMPARED AND WE 2718 01:48:01,443 --> 01:48:02,912 CAN PICK THE BEST ONES GOING 2719 01:48:02,912 --> 01:48:08,984 FORWARD. WE'RE GOING TO HAVE TO 2720 01:48:08,984 --> 01:48:10,753 MOVE MORE TOWARDS THESE 2721 01:48:10,753 --> 01:48:11,921 ANNOUNCEMENTS. AS ANDY 2722 01:48:11,921 --> 01:48:13,489 MENTIONED NOT ONLY DO THEY WANT 2723 01:48:13,489 --> 01:48:15,724 TO CUT THESE BUT THEY'RE GOING 2724 01:48:15,724 --> 01:48:17,393 TO REQUIRE HHS APPROVAL AND 2725 01:48:17,393 --> 01:48:18,794 THEY'RE GOING TO REQUIRE 2726 01:48:18,794 --> 01:48:19,962 APPROVAL EVEN BEFORE WE PRESENT 2727 01:48:19,962 --> 01:48:21,096 THEM TO THE COUNCIL SO THAT 2728 01:48:21,096 --> 01:48:23,365 MEANS THINGS ARE REALLY GOING TO 2729 01:48:23,365 --> 01:48:24,466 SLOW DOWN SO WE'RE NOT GOING TO 2730 01:48:24,466 --> 01:48:27,169 BE ABLE TO RELY ON THEM AS MUCH 2731 01:48:27,169 --> 01:48:30,139 AND THIS IS PARTICULARLY A 2732 01:48:30,139 --> 01:48:32,808 PROBLEM AS I'LL SHOW YOU WHEN IT 2733 01:48:32,808 --> 01:48:34,310 COMES TO THE PARTICULAR PROJECTS 2734 01:48:34,310 --> 01:48:37,479 THAT WE HAVE THAT ARE 2735 01:48:37,479 --> 01:48:39,148 CONGRESSIONALLY MANDATED LIKE 2736 01:48:39,148 --> 01:48:42,618 HEAL, THE ALS PROJECT, THE BRAIN 2737 01:48:42,618 --> 01:48:44,753 INITIATIVE. AS JAY MENTIONED 2738 01:48:44,753 --> 01:48:48,123 THERE'S A HALT ON FOREIGN 2739 01:48:48,123 --> 01:48:50,759 SUBAWARDS. AND HE'S RIGHT THAT 2740 01:48:50,759 --> 01:48:53,395 NIH NEVER HAD A MECHANISM WHERE 2741 01:48:53,395 --> 01:48:54,763 THEY COULD REPORT TO CONGRESS 2742 01:48:54,763 --> 01:48:55,397 ABOUT HOW MUCH MONEY WAS GOING 2743 01:48:55,397 --> 01:48:59,268 TO FOREIGN COUNTRIES. I THOUGHT 2744 01:48:59,268 --> 01:49:00,603 THAT THIS WAS A PROBLEM AT SOME 2745 01:49:00,603 --> 01:49:02,338 POINT AND IT CERTAINLY TURNED 2746 01:49:02,338 --> 01:49:04,974 OUT TO BE THAT AND THAT'S 2747 01:49:04,974 --> 01:49:06,775 BECAUSE MOST OF THE MONEY GOING 2748 01:49:06,775 --> 01:49:10,012 OUT IS TO INDIVIDUAL GRANTS. 2749 01:49:10,012 --> 01:49:11,614 AND THERE'S NO MECHANISM TO 2750 01:49:11,614 --> 01:49:12,881 CAPTURE THAT BUT NOW THOSE ARE 2751 01:49:12,881 --> 01:49:14,450 STOPPED AND THEY'RE LOOKING 2752 01:49:14,450 --> 01:49:16,852 FORWARD TO A NEW PROCESS BY 2753 01:49:16,852 --> 01:49:19,121 WHICH FOREIGN GROUPS THAT ARE 2754 01:49:19,121 --> 01:49:22,758 PART OF OUR RESEARCH KIND OF 2755 01:49:22,758 --> 01:49:26,762 SEND IN THEIR OWN APPLICATION. 2756 01:49:26,762 --> 01:49:29,465 TO GET FUNDS SENT DIRECTLY 2757 01:49:29,465 --> 01:49:30,599 OVERSEAS SO THAT IS WHAT WE 2758 01:49:30,599 --> 01:49:32,668 HEARD IS THE PLAN GOING FORWARD. 2759 01:49:32,668 --> 01:49:34,436 NOW OF COURSE SOME OF THE PLACES 2760 01:49:34,436 --> 01:49:35,504 OVERSEAS PARTICULARLY IN THE 2761 01:49:35,504 --> 01:49:36,705 UNDERDEVELOPED COUNTRIES ARE 2762 01:49:36,705 --> 01:49:38,807 GOING TO HAVE A HARD TIME 2763 01:49:38,807 --> 01:49:42,011 SUBMITTING A GRANT TO NIH SO IT 2764 01:49:42,011 --> 01:49:45,614 COULD BE A PROBLEM. NOW AS YOU 2765 01:49:45,614 --> 01:49:46,515 PROBABLY HEARD, THERE ARE A 2766 01:49:46,515 --> 01:49:51,754 NUMBER OF TYPES OF GRANTS THAT 2767 01:49:51,754 --> 01:49:53,656 WERE TAKEN THAT ARE WHAT IS 2768 01:49:53,656 --> 01:49:55,924 CALLED TERMINATED OR THEY WERE 2769 01:49:55,924 --> 01:49:57,960 TAKEN OUT OF REVIEW BECAUSE THEY 2770 01:49:57,960 --> 01:49:59,862 DID NOT COMPLY WITH THE 2771 01:49:59,862 --> 01:50:03,032 EXECUTIVE ORDERS THAT CAME UNDER 2772 01:50:03,032 --> 01:50:06,168 THE NEW ADMINISTRATION. AND SO 2773 01:50:06,168 --> 01:50:07,770 I THINK, YOU KNOW, THERE'S SOME 2774 01:50:07,770 --> 01:50:09,872 REALLY GOOD SCIENCE THAT IS NOT 2775 01:50:09,872 --> 01:50:11,507 GOING TO BE ABLE TO BE DONE, 2776 01:50:11,507 --> 01:50:12,941 THERE'S UNFORTUNATELY A LOT OF 2777 01:50:12,941 --> 01:50:14,677 CAREER DEVELOPMENT GRANTS THAT 2778 01:50:14,677 --> 01:50:18,347 ARE NOT GOING TO BE -- THAT WERE 2779 01:50:18,347 --> 01:50:20,482 NOT AWARDED. AND SO THAT, YOU 2780 01:50:20,482 --> 01:50:21,750 KNOW, REALLY PUTS US BACK, THE 2781 01:50:21,750 --> 01:50:23,819 OTHER THING WHICH I WILL MENTION 2782 01:50:23,819 --> 01:50:26,689 IS THAT THERE'S ALSO A LARGE 2783 01:50:26,689 --> 01:50:29,958 CHUNK OF MONEY NOW THAT WE HAD 2784 01:50:29,958 --> 01:50:34,663 PLANNED TO AWARD THAT IS NOT 2785 01:50:34,663 --> 01:50:35,831 GOING TO BE POSSIBLE TO AWARD IN 2786 01:50:35,831 --> 01:50:37,399 THE WAY THAT WE PLANNED. WE 2787 01:50:37,399 --> 01:50:38,767 WILL TALK ABOUT THAT IN A SE 2788 01:50:38,767 --> 01:50:43,939 SECOND. SO LOOKING TO THE 2789 01:50:43,939 --> 01:50:47,910 BUDGET, THAT'S WHERE THE REAL 2790 01:50:47,910 --> 01:50:50,779 UNCERTAINTIES COME. SO I'M 2791 01:50:50,779 --> 01:50:53,816 SHOWING HERE THE BUDGET FROM 2792 01:50:53,816 --> 01:50:56,318 21-25 AS YOU KNOW WE'RE IN AN 2793 01:50:56,318 --> 01:50:57,686 ACTED CONTINUED RESOLUTION, WE 2794 01:50:57,686 --> 01:50:58,754 KNEW HAVE THE SAME AMOUNT OF 2795 01:50:58,754 --> 01:51:00,789 MONEY THAT WE HAD LAST YEAR. 2796 01:51:00,789 --> 01:51:03,826 WITH THE EXCEPTION OF CHANGES TO 2797 01:51:03,826 --> 01:51:09,765 THE CURES FUNDING. THE... BUT 2798 01:51:09,765 --> 01:51:13,469 LOOKING FORWARD IS NOT A LOT OF 2799 01:51:13,469 --> 01:51:15,270 CLAR 2800 01:51:15,270 --> 01:51:16,905 CLARITY. THE ONLY THING WE HAVE 2801 01:51:16,905 --> 01:51:18,440 TO WORK WITH IS THE TOP DOWN 2802 01:51:18,440 --> 01:51:20,576 LINE ITEM FROM THE PRESIDENT'S 2803 01:51:20,576 --> 01:51:22,778 PLAN WHICH IS A CALLING FOR A 2804 01:51:22,778 --> 01:51:28,650 40% DECREASE IN THE NIH BUDGET. 2805 01:51:28,650 --> 01:51:31,286 NOW THAT IS A LITTLE BIT 2806 01:51:31,286 --> 01:51:32,654 UNCERTAIN ABOUT WHAT THAT MEANS 2807 01:51:32,654 --> 01:51:38,360 FOR THE INDIVIDUAL INSTITUTES. 2808 01:51:38,360 --> 01:51:40,696 WE DON'T HAVE ANY INFORMATION 2809 01:51:40,696 --> 01:51:42,765 ALTHOUGH THINGS DID LEAK OUT IN 2810 01:51:42,765 --> 01:51:44,867 THE PRESS ABOUT POTENTIAL 2811 01:51:44,867 --> 01:51:48,237 INSTITUTES MOVING OUT OF NIH. 2812 01:51:48,237 --> 01:51:54,042 SOME CONSTITUTES CLOSING, SOME 2813 01:51:54,042 --> 01:51:56,412 INSTITUTES COMBINING, WHAT IT 2814 01:51:56,412 --> 01:51:58,814 MEANS FOR US IS NOT CLEAR, AS 2815 01:51:58,814 --> 01:52:01,884 YOU KNOW, ABOUT 70% OF OUR MONEY 2816 01:52:01,884 --> 01:52:05,087 IS TAKEN UP IN WHAT WE CALL 2817 01:52:05,087 --> 01:52:06,555 NON-COMPETING WHICH IS, YOU 2818 01:52:06,555 --> 01:52:09,558 KNOW, THOSE ARE OUR GRANTS THAT 2819 01:52:09,558 --> 01:52:12,961 GO ON FOR FIVE YEARS AND SO MOST 2820 01:52:12,961 --> 01:52:17,499 OF OUR MONEY IS OUT THERE AND 2821 01:52:17,499 --> 01:52:19,601 COMMITMENTS TO GRANTS SO A 40% 2822 01:52:19,601 --> 01:52:22,938 DECREASE WOULD MAKE IT HARD TO 2823 01:52:22,938 --> 01:52:26,108 ACTUALLY MEET OUR COMMITMENTS 2824 01:52:26,108 --> 01:52:30,012 LET ALONE FUND ANY NEW GRANTS. 2825 01:52:30,012 --> 01:52:31,713 SO HOPING THAT AS THE HOUSE AND 2826 01:52:31,713 --> 01:52:35,717 THE SENATE WORK ON A COMPROMISED 2827 01:52:35,717 --> 01:52:38,487 BUDGET THAT WE GET SOMETHING, 2828 01:52:38,487 --> 01:52:39,488 YOU KNOW, IS GOING TO HELP US 2829 01:52:39,488 --> 01:52:42,758 MOVE FORWARD BUT THIS IS, YOU 2830 01:52:42,758 --> 01:52:46,462 KNOW, THERE'S 40% DECREASE IS 2831 01:52:46,462 --> 01:52:49,932 CERTAINLY A WORRISOME FEATURE 2832 01:52:49,932 --> 01:52:54,937 RIGHT NOW. OKAY. WHAT WE'RE 2833 01:52:54,937 --> 01:52:58,774 GOING TO, AS I MENTIONED BEFORE, 2834 01:52:58,774 --> 01:53:03,946 THERE'S A SIGNIFICANT SUM OF 2835 01:53:03,946 --> 01:53:05,414 FUNDS THAT WERE NOT AWARDED AS 2836 01:53:05,414 --> 01:53:09,418 WE HAD PREVIOUSLY PLANNED. NOW 2837 01:53:09,418 --> 01:53:12,821 SOME OF THOSE PROJECTS ARE THE 2838 01:53:12,821 --> 01:53:13,822 MONEY'S ON HOLD. SOME OF THEM 2839 01:53:13,822 --> 01:53:15,757 ARE COMPLETELY TERMINATED. SOME 2840 01:53:15,757 --> 01:53:17,392 OF THEM ARE ON HOLD. IT'S 2841 01:53:17,392 --> 01:53:19,094 POSSIBLE THAT SOME OF THOSE 2842 01:53:19,094 --> 01:53:20,362 PROJECTS THAT ARE ON HOLD, YOU 2843 01:53:20,362 --> 01:53:23,499 KNOW, IF THEY GO, IF THERE'S A 2844 01:53:23,499 --> 01:53:24,466 COURT DECISION THEN WE MAY PAY 2845 01:53:24,466 --> 01:53:28,203 THOSE PROJECTS. SO IT'S NOT 2846 01:53:28,203 --> 01:53:30,472 NECESSARILY CLEAR TO US HOW MUCH 2847 01:53:30,472 --> 01:53:33,075 OF THAT FUNDING WILL NOT THEN 2848 01:53:33,075 --> 01:53:34,376 COME BACK ONTO OUR BUDGET SHEETS 2849 01:53:34,376 --> 01:53:37,613 IN THE FUTURE. SO WE HAVE TO BE 2850 01:53:37,613 --> 01:53:41,049 A LITTLE BIT CAREFUL, OR VERY 2851 01:53:41,049 --> 01:53:42,651 CAREFUL, AND SO THE PLAN IS TO 2852 01:53:42,651 --> 01:53:44,953 INSTEAD OF AWARDING MORE GRANTS 2853 01:53:44,953 --> 01:53:46,522 WITH THOSE FUNDS, IS TO USE 2854 01:53:46,522 --> 01:53:48,390 THOSE FUNDS TO MAKE MULTIYEAR 2855 01:53:48,390 --> 01:53:52,060 FUND AWARDS. SO THAT AND THAT 2856 01:53:52,060 --> 01:53:54,930 WOULD ALLOW US TO MOVE THE MONEY 2857 01:53:54,930 --> 01:53:58,100 OUT TO DO SCIENCE AND TAKE THE 2858 01:53:58,100 --> 01:54:01,937 PRESSURE OFF THE, SAME AND 2859 01:54:01,937 --> 01:54:06,508 SIMILAR CIRCUMSTANCE -- SAY 2860 01:54:06,508 --> 01:54:06,775 2026-27. 2861 01:54:06,775 --> 01:54:08,877 FOR MULTIYEAR FUNDING WE USUALLY 2862 01:54:08,877 --> 01:54:12,214 FUND GRANTS EVERY YEAR. SO IN 2863 01:54:12,214 --> 01:54:19,621 THIS SITUATION, A GRANT GETS 2864 01:54:19,621 --> 01:54:23,325 400,000 THE FIRST YEAR AND EVERY 2865 01:54:23,325 --> 01:54:25,627 SUBSEQUENT YEAR. THIS IS ALWAYS 2866 01:54:25,627 --> 01:54:26,762 CONTINGENT ON FUNDS BEING 2867 01:54:26,762 --> 01:54:27,896 AVAILABLE FROM THE GOVERNMENT 2868 01:54:27,896 --> 01:54:28,564 BUT THAT'S GENERALLY WHAT WE'VE 2869 01:54:28,564 --> 01:54:30,799 BEEN ABLE TO DO WITH OUR OUT 2870 01:54:30,799 --> 01:54:32,334 YEAR COMMITMENTS AND SO 2871 01:54:32,334 --> 01:54:35,404 THEREFORE ABOUT 75% OF OUR FUNDS 2872 01:54:35,404 --> 01:54:39,775 ARE RESERVED FOR NON-COMPETING 2873 01:54:39,775 --> 01:54:42,144 AWARDS, THE CONTINUATIONS. IN 2874 01:54:42,144 --> 01:54:42,811 MULTIYEAR FUNDING WHAT WE COULD 2875 01:54:42,811 --> 01:54:45,314 DO IS FUND NOT JUST THE FIRST 2876 01:54:45,314 --> 01:54:48,050 YEAR BUT THE SECOND AND THIRD 2877 01:54:48,050 --> 01:54:50,752 YEAR OF THE GRANT. WITH THE 2878 01:54:50,752 --> 01:54:52,654 MONEY THAT WE HAVE NOW IN '25 2879 01:54:52,654 --> 01:54:54,890 AND THAT WOULD MEAN THAT THOSE 2880 01:54:54,890 --> 01:54:57,392 GRANTS DON'T NEED ANY ADDITIONAL 2881 01:54:57,392 --> 01:55:00,362 FUNDING IN '26 OR '27. WE ALSO 2882 01:55:00,362 --> 01:55:02,097 HAVE THE ABILITY THIS YEAR FOR 2883 01:55:02,097 --> 01:55:03,665 THE FIRST TIME TO MULTIYEAR FUND 2884 01:55:03,665 --> 01:55:06,768 THE LAST TWO YEARS OF AN AWARD. 2885 01:55:06,768 --> 01:55:08,437 WHICH WOULD THEN GET THAT GRANT 2886 01:55:08,437 --> 01:55:11,807 OFF OUR BOOKS FOR REQUIRING ANY 2887 01:55:11,807 --> 01:55:14,142 MONEY IN THE FUTURE. SO I THINK 2888 01:55:14,142 --> 01:55:15,877 WE'RE GOING TO MOVE HEAVILY INTO 2889 01:55:15,877 --> 01:55:19,448 THIS SPACE AND THAT WOULD ALLOW 2890 01:55:19,448 --> 01:55:21,116 US A -- PUT US IN A BETTER 2891 01:55:21,116 --> 01:55:26,755 POSITION IN 2026. SHOULD THE 2892 01:55:26,755 --> 01:55:31,293 BUDGET REALLY LOOK 2893 01:55:31,293 --> 01:55:32,661 JUST TO SAY, THIS SLIDE, WE 2894 01:55:32,661 --> 01:55:39,801 TALKED ABOUT THE BASE BUDGET FOR 2895 01:55:39,801 --> 01:55:42,704 NINDS IN THE PAST SLIDE BUT I 2896 01:55:42,704 --> 01:55:45,540 WANTED TO MENTION WE ARE THE 2897 01:55:45,540 --> 01:55:50,612 LEAD, CO-READ WITH NIMH FOR THE 2898 01:55:50,612 --> 01:55:51,613 HEAL INITIATIVE WITH THE BRAIN 2899 01:55:51,613 --> 01:55:52,848 AND CURES ACT MONEY, THERE'S AN 2900 01:55:52,848 --> 01:55:58,086 INCREASE IN THE CURES ACT MONEY 2901 01:55:58,086 --> 01:55:59,254 IN 2026, THE HEAL INITIATIVE WE 2902 01:55:59,254 --> 01:56:06,695 MANAGE ALL THE FUNDS FOR THE 2903 01:56:06,695 --> 01:56:10,165 WORK DEVELOPED NON-ADDICTIVE 2904 01:56:10,165 --> 01:56:13,502 PAIN THERAPEUTICS, ADRD, WE GET 2905 01:56:13,502 --> 01:56:13,969 $85 MILLION THERE FOR 2906 01:56:13,969 --> 01:56:14,536 ALZHEIMER'S DISEASE, RELATED 2907 01:56:14,536 --> 01:56:16,438 DEMENTIA WORK. 2908 01:56:16,438 --> 01:56:20,409 AND WE HAVE $2 MILLION FROM 2909 01:56:20,409 --> 01:56:26,048 UNDIAGNOSED DISEASE NETWORK, IN 2910 01:56:26,048 --> 01:56:27,649 2025, QUESTION MARKS FOR 2026, 2911 01:56:27,649 --> 01:56:30,385 WE'VE NOT HEARD ANYTHING ABOUT 2912 01:56:30,385 --> 01:56:33,855 HOW THESE FUNDS MIGHT OR MAY NOT 2913 01:56:33,855 --> 01:56:36,358 APPEAR IN 2026 FOR THESE 2914 01:56:36,358 --> 01:56:40,195 SPECIALIZED PROGRAMS, PUTS US IN 2915 01:56:40,195 --> 01:56:42,197 ANOTHER BIND. 2916 01:56:42,197 --> 01:56:42,964 IN ADDITION WE MANAGE $75 2917 01:56:42,964 --> 01:56:45,500 MILLION FOR THE ACT FOR ALS, 2918 01:56:45,500 --> 01:56:50,405 WHICH IS A BILL THAT WAS SIGNED 2919 01:56:50,405 --> 01:56:56,278 TO SET UP EXPANDED ACCESS 2920 01:56:56,278 --> 01:56:58,480 TRIALS, AND PUBLIC/PRIVATE 2921 01:56:58,480 --> 01:56:59,181 PARTNERSHIP CALLED THE 2922 01:56:59,181 --> 01:57:03,151 ACCELERATED MEDICINE PARTNERSHIP 2923 01:57:03,151 --> 01:57:08,590 FOR ALS, TO DEVELOP A LARGE 2924 01:57:08,590 --> 01:57:11,493 DATABASE TO EXPLORE FOR 2925 01:57:11,493 --> 01:57:15,964 BIOMARKERS AND TARGETS FOR ALS 2926 01:57:15,964 --> 01:57:16,298 THERAPEUTICS. 2927 01:57:16,298 --> 01:57:17,265 AND, AGAIN, THAT QUESTION MARK 2928 01:57:17,265 --> 01:57:19,468 IS ALSO UP THERE, WHETHER THOSE 2929 01:57:19,468 --> 01:57:21,870 FUNDS WILL COME IN 2026 OR NOT. 2930 01:57:21,870 --> 01:57:23,572 WE HAVE -- THE MAIN ISSUE WE 2931 01:57:23,572 --> 01:57:25,507 HAVE A LOT OF UNCERTAINTIES. 2932 01:57:25,507 --> 01:57:26,775 WE HAVE TO WAIT AND SEE WHAT 2933 01:57:26,775 --> 01:57:28,143 HAPPENS, AND WE'RE TRYING TO 2934 01:57:28,143 --> 01:57:29,644 PROTECT THE BUDGET AS BEST WE 2935 01:57:29,644 --> 01:57:35,984 CAN WITH THE TOOLS THAT ARE 2936 01:57:35,984 --> 01:57:36,885 AVAILABLE. 2937 01:57:36,885 --> 01:57:37,085 OKAY. 2938 01:57:37,085 --> 01:57:39,488 YOU'VE SEEN THIS BEFORE, SO WHEN 2939 01:57:39,488 --> 01:57:42,758 WE TALK ABOUT THE BUDGET, 2940 01:57:42,758 --> 01:57:46,061 IMPORTANT TO KNOW IS THAT 2941 01:57:46,061 --> 01:57:47,829 BESIDES THE AMOUNT WE GET FROM 2942 01:57:47,829 --> 01:57:50,165 CONGRESS, WE ALSO HAVE TO PAY 2943 01:57:50,165 --> 01:57:51,867 ATTENTION TO THE COST OF DOING 2944 01:57:51,867 --> 01:57:52,100 SCIENCE. 2945 01:57:52,100 --> 01:57:53,769 OF COURSE, THAT HAS BEEN 2946 01:57:53,769 --> 01:57:56,138 INCREASING PARTICULARLY OVER THE 2947 01:57:56,138 --> 01:57:56,905 LAST COUPLE YEARS. 2948 01:57:56,905 --> 01:58:01,042 BUT HERE ON THE ORANGE BELOW YOU 2949 01:58:01,042 --> 01:58:02,344 CAN SEE THE INCREASED COST OF A 2950 01:58:02,344 --> 01:58:04,546 GRANT, IF YOU LOOK AT REAL 2951 01:58:04,546 --> 01:58:07,048 DOLLARS LOOKING FROM 2024 ON, 2952 01:58:07,048 --> 01:58:08,717 REALLY HASN'T CHANGED AT ALL. 2953 01:58:08,717 --> 01:58:11,820 SO IN FACT THE INCREASED COST OF 2954 01:58:11,820 --> 01:58:14,122 SCIENCE IS REALLY TIED TO 2955 01:58:14,122 --> 01:58:17,626 INFLATION, AND IF WE LOOK AT 2956 01:58:17,626 --> 01:58:23,865 WHAT A -- HOW MUCH IT COSTS TO 2957 01:58:23,865 --> 01:58:26,902 MOVE A PAYLINE FROM 8th TO 2958 01:58:26,902 --> 01:58:28,303 9th PERCENTILE BECAUSE OF 2959 01:58:28,303 --> 01:58:29,738 INCREASED COST OF GRANTS THAT 2960 01:58:29,738 --> 01:58:31,706 NUMBER IS MOVED FROM, YOU KNOW, 2961 01:58:31,706 --> 01:58:32,841 PROBABLY ABOUT $10 MILLION BACK 2962 01:58:32,841 --> 01:58:36,645 HERE WHEN I CAME TO NOW $24 2963 01:58:36,645 --> 01:58:36,878 MILLION. 2964 01:58:36,878 --> 01:58:38,814 SO THINGS ARE DEFINITELY MORE 2965 01:58:38,814 --> 01:58:43,151 EXPENSIVE IN DOLLARS, BUT IF YOU 2966 01:58:43,151 --> 01:58:44,619 ADJUSTED TO BIOMEDICAL INFLATION 2967 01:58:44,619 --> 01:58:45,954 IS NOT REALLY THAT MUCH 2968 01:58:45,954 --> 01:58:49,357 DIFFERENT, SO IT'S REALLY 2969 01:58:49,357 --> 01:58:51,860 HEAVILY DRIVEN BY INFLATION. 2970 01:58:51,860 --> 01:58:56,097 WE MENTIONED A LITTLE BIT ABOUT 2971 01:58:56,097 --> 01:58:58,333 THE CENTRALIZATION OF REVIEW, SO 2972 01:58:58,333 --> 01:58:59,668 REMEMBER THE WAY OUR PROCESS 2973 01:58:59,668 --> 01:59:03,738 WORKS IS A VERY AMERICAN 2974 01:59:03,738 --> 01:59:04,806 PROCESS. 2975 01:59:04,806 --> 01:59:05,941 INVESTIGATOR CAN SUBMIT AN 2976 01:59:05,941 --> 01:59:11,513 APPLICATION FOR MANY OF THE 2977 01:59:11,513 --> 01:59:14,749 GRANTS, CENTER FOR SCIENTIFIC 2978 01:59:14,749 --> 01:59:15,851 REVIEW ASSIGNS THE APPLICATION 2979 01:59:15,851 --> 01:59:17,652 TO AN INSTITUTE. 2980 01:59:17,652 --> 01:59:19,754 IT GOES TO REVIEW. 2981 01:59:19,754 --> 01:59:25,126 MOST OF THE R01 GRANTS, R21s, 2982 01:59:25,126 --> 01:59:28,897 THE Fs, SBIRs GO TO THE 2983 01:59:28,897 --> 01:59:30,866 CENTER FOR SCIENTIFIC REVIEW, 2984 01:59:30,866 --> 01:59:31,967 ABOUT 78% OF APPLICATIONS GO 2985 01:59:31,967 --> 01:59:33,835 THERE FOR REVIEW. 2986 01:59:33,835 --> 01:59:38,506 WE REVIEW IN HOUSE THE TRAINING 2987 01:59:38,506 --> 01:59:39,875 GRANTS, CLINICAL SCIENCE GRANTS, 2988 01:59:39,875 --> 01:59:41,743 PROGRAM PROJECT GRANTS. 2989 01:59:41,743 --> 01:59:43,678 MOST OF OUR THERAPY DEVELOPMENT 2990 01:59:43,678 --> 01:59:45,480 PROGRAMS WHICH ARE REALLY 2991 01:59:45,480 --> 01:59:48,450 SOMEWHAT UNIQUE TO NIH ARE 2992 01:59:48,450 --> 01:59:49,618 REVIEWED IN-HOUSE AS WELL AS OUR 2993 01:59:49,618 --> 01:59:52,053 CLINICAL TRIALS, A NUMBER OF OUR 2994 01:59:52,053 --> 01:59:52,454 CONTRACTS. 2995 01:59:52,454 --> 01:59:55,190 SO, NOW ALL THIS IS GOING TO 2996 01:59:55,190 --> 01:59:56,057 HAVE TO GO INTO CSR. 2997 01:59:56,057 --> 01:59:58,960 AND THEN IT'S GOING TO COME OUT 2998 01:59:58,960 --> 02:00:01,296 TO THE PROGRAM DIRECTORS TO 2999 02:00:01,296 --> 02:00:02,597 START LOOKING AT THESE GRANTS 3000 02:00:02,597 --> 02:00:05,300 WITH MAYBE NOT THE SAME LEVEL OF 3001 02:00:05,300 --> 02:00:06,601 REVIEW THAT WE HAD BEFORE, AND 3002 02:00:06,601 --> 02:00:08,436 WE'RE GOING TO HAVE TO MAKE 3003 02:00:08,436 --> 02:00:09,671 DECISIONS TO BRING TO COUNCIL 3004 02:00:09,671 --> 02:00:12,240 AND I THINK SO THIS COULD ALSO 3005 02:00:12,240 --> 02:00:14,609 INCREASE THE NEED FOR COUNCIL TO 3006 02:00:14,609 --> 02:00:17,646 TAKE CAREFUL LOOKS AT MANY OF 3007 02:00:17,646 --> 02:00:18,413 THESE -- PARTICULARLY THE LARGE 3008 02:00:18,413 --> 02:00:21,917 SPECIAL PROJECTS THAT COME OUT 3009 02:00:21,917 --> 02:00:23,418 OF THE CSR REVIEW, PARTICULARLY 3010 02:00:23,418 --> 02:00:27,188 IN BEGINNING YEARS, UNTIL WE GET 3011 02:00:27,188 --> 02:00:28,156 TO A NORMALIZED STATE. 3012 02:00:28,156 --> 02:00:31,259 IF YOU LOOK AT THE NUMBER OF 3013 02:00:31,259 --> 02:00:32,527 GRANTS, THIS IS THE DOLLARS. 3014 02:00:32,527 --> 02:00:36,731 IF YOU LOOK AT THE NUMBERS THAT 3015 02:00:36,731 --> 02:00:39,134 ARE REVIEWED IN HOUSE, THE 3016 02:00:39,134 --> 02:00:44,372 PERCENT IS ABOUT 33, 34% FOR US. 3017 02:00:44,372 --> 02:00:47,309 AND BUT IF YOU LOOK AT "HEAL" 3018 02:00:47,309 --> 02:00:48,643 AND BRAIN INITIATIVE, IT'S IN 3019 02:00:48,643 --> 02:00:49,611 THE 80 TO 90% RANGE. 3020 02:00:49,611 --> 02:00:58,353 SO THIS IS WHERE WE HAVE OUR 3021 02:00:58,353 --> 02:01:01,089 BIGGEST PROBLEMS GOING FORWARD. 3022 02:01:01,089 --> 02:01:01,423 OKAY. 3023 02:01:01,423 --> 02:01:03,892 SO, I WANT TO JUST KIND OF 3024 02:01:03,892 --> 02:01:05,827 EMPHASIZE AGAIN THE PRIORITIES 3025 02:01:05,827 --> 02:01:07,462 AS WE ENTER THIS DIFFICULT 3026 02:01:07,462 --> 02:01:07,662 SPACE. 3027 02:01:07,662 --> 02:01:09,831 ONE IS WE'D LIKE TO PROTECT THE 3028 02:01:09,831 --> 02:01:14,836 PAYLINE TO KEEP THE RESEARCH 3029 02:01:14,836 --> 02:01:15,971 ECOSYSTEM, YOU KNOW, AT LEAST 3030 02:01:15,971 --> 02:01:18,740 OUT OF THE INTENSIVE CARE UNIT, 3031 02:01:18,740 --> 02:01:20,675 IF WE CAN. 3032 02:01:20,675 --> 02:01:23,478 I THINK 8 PERCENTILE IS CLOSE TO 3033 02:01:23,478 --> 02:01:25,880 GOING IN THE INTENSIVE CARE UNIT 3034 02:01:25,880 --> 02:01:27,949 FOR THE RESEARCH ECOSYSTEM THAT 3035 02:01:27,949 --> 02:01:29,484 WE'RE TRYING TO MAINTAIN. 3036 02:01:29,484 --> 02:01:31,886 SO WE DO THAT, WE TRY TO FUND AS 3037 02:01:31,886 --> 02:01:34,289 MANY INVESTIGATORS AS POSSIBLE, 3038 02:01:34,289 --> 02:01:35,824 EVEN IF THAT MEANS REDUCING THE 3039 02:01:35,824 --> 02:01:39,294 SIZE OF EACH AWARD. 3040 02:01:39,294 --> 02:01:40,762 WE'D LIKE TO REALLY NOT MORTGAGE 3041 02:01:40,762 --> 02:01:45,500 THE FUTURE OF OUR SCIENCE BY 3042 02:01:45,500 --> 02:01:49,571 LOSING EARLY STAGE TRAINEES AND 3043 02:01:49,571 --> 02:01:50,438 EARLY-STAGE INVESTIGATORS, THOSE 3044 02:01:50,438 --> 02:01:52,807 WOULD BE OUR HIGHEST PRIORITY TO 3045 02:01:52,807 --> 02:01:56,411 KEEP GOING. 3046 02:01:56,411 --> 02:01:58,113 AND THEN WE ALSO HAVE AS A 3047 02:01:58,113 --> 02:02:01,883 LEADER HERE THE ONLY INSTITUTE 3048 02:02:01,883 --> 02:02:02,751 THAT'S 100% NEUROSCIENCE REALLY 3049 02:02:02,751 --> 02:02:05,920 WANT TO DO EVERYTHING WE CAN TO 3050 02:02:05,920 --> 02:02:12,127 MOVE NIH NEUROSCIENCE AS WELL BY 3051 02:02:12,127 --> 02:02:13,361 THESE TRANS-NIH ACTIVITIES. 3052 02:02:13,361 --> 02:02:17,365 AND, YOU KNOW, AS MENTIONED 3053 02:02:17,365 --> 02:02:18,299 DURING THE DISCUSSIONS, AND JAY 3054 02:02:18,299 --> 02:02:20,135 ALSO, WE HAVE TO TRY TO 3055 02:02:20,135 --> 02:02:21,302 ELIMINATE THE HEALTH DISPARITIES 3056 02:02:21,302 --> 02:02:25,573 AND INEQUITIES IN THE NEUROLOGIC 3057 02:02:25,573 --> 02:02:26,875 EDITIONS BY USING THINGS WE KNOW 3058 02:02:26,875 --> 02:02:30,745 WORK TO MAKE SURE THAT PEOPLE 3059 02:02:30,745 --> 02:02:32,280 CAN GET ACCESS TO THEM AND 3060 02:02:32,280 --> 02:02:36,684 DRIVES THE BURDEN OF DISEASE 3061 02:02:36,684 --> 02:02:37,085 DOWN. 3062 02:02:37,085 --> 02:02:37,285 OKAY. 3063 02:02:37,285 --> 02:02:39,921 IF YOU LOOK AT THE NUMBER OF 3064 02:02:39,921 --> 02:02:41,022 INVESTIGATORS, SO WE ACTUALLY 3065 02:02:41,022 --> 02:02:42,457 DID WHAT WE WANTED TO DO, WHICH 3066 02:02:42,457 --> 02:02:45,093 IS INCREASE THE NUMBER OF 3067 02:02:45,093 --> 02:02:45,894 INVESTIGATORS OVER THOSE YEARS 3068 02:02:45,894 --> 02:02:48,830 AS OUR BUDGET WAS INCREASING YOU 3069 02:02:48,830 --> 02:02:59,274 CAN SEE WE WENT FROM ABOUT 3070 02:03:00,375 --> 02:03:02,477 ALMOST 2050 TO 2500 OUT OF THE 3071 02:03:02,477 --> 02:03:04,813 BASE BUDGET. 3072 02:03:04,813 --> 02:03:07,715 WHEN YOU ADD "HEAL," BRAIN, 3073 02:03:07,715 --> 02:03:10,752 ADRD, WE ALMOST DOUBLED THE 3074 02:03:10,752 --> 02:03:12,654 NUMBER OF INVESTIGATORS COMING 3075 02:03:12,654 --> 02:03:13,955 INTO R01-EQUIVALENT GRANTS. 3076 02:03:13,955 --> 02:03:16,558 SO WE WERE ABLE TO CERTAINLY 3077 02:03:16,558 --> 02:03:19,794 ACHIEVE THAT GOAL AND THAT'S WHY 3078 02:03:19,794 --> 02:03:22,330 I THINK OUR FIELD IS SO FULL OF 3079 02:03:22,330 --> 02:03:25,834 REALLY GREAT IDEAS TO MOVE 3080 02:03:25,834 --> 02:03:26,067 FORWARD. 3081 02:03:26,067 --> 02:03:29,137 NOW, AS WE GO FORWARD, WE DON'T 3082 02:03:29,137 --> 02:03:30,772 HAVE THE OPPORTUNITY YET TO 3083 02:03:30,772 --> 02:03:32,774 REALLY DO WITH OUR WEBSITE WHAT 3084 02:03:32,774 --> 02:03:37,979 WE NEED TO DO TO COMMUNICATE TO 3085 02:03:37,979 --> 02:03:38,746 THE OUTSIDE COMMUNITY BUT WE'RE 3086 02:03:38,746 --> 02:03:41,616 GOING TO TRY AS BEST WE CAN VERY 3087 02:03:41,616 --> 02:03:42,784 SHORTLY. 3088 02:03:42,784 --> 02:03:46,788 AS I MENTIONED, WITH THE 3089 02:03:46,788 --> 02:03:48,556 NOFOs, NUMBER OF NOFOs 3090 02:03:48,556 --> 02:03:50,158 DROPPING, WE'RE GOING TO BE 3091 02:03:50,158 --> 02:03:52,527 INDICATING ON THE WEBSITE THE 3092 02:03:52,527 --> 02:03:54,662 AREAS OF INTEREST THAT WE'RE 3093 02:03:54,662 --> 02:03:57,132 LOOKING FOR GRANTS, PARTICULARLY 3094 02:03:57,132 --> 02:03:58,466 IN THESE CONGRESSIONALLY 3095 02:03:58,466 --> 02:04:00,668 MANDATED AREAS LIKE BRAIN OR 3096 02:04:00,668 --> 02:04:02,470 HEAL OR ADRD. 3097 02:04:02,470 --> 02:04:05,173 PEOPLE, PLEASE START PAYING MORE 3098 02:04:05,173 --> 02:04:07,542 ATTENTION TO THE NINDS FUNDING 3099 02:04:07,542 --> 02:04:10,745 SITE, FUNDING SECTION. 3100 02:04:10,745 --> 02:04:11,813 FOR MANY NOTICE OF FUNDING 3101 02:04:11,813 --> 02:04:14,649 OPPORTUNITIES THEY ARE NOW GONE, 3102 02:04:14,649 --> 02:04:17,785 SO THEY WERE TAKEN DOWN BY THE 3103 02:04:17,785 --> 02:04:18,987 OFFICE OF EXTRAMURAL RESEARCH, 3104 02:04:18,987 --> 02:04:21,322 AND SO IF YOU HAVE A GRANT AND 3105 02:04:21,322 --> 02:04:23,625 YOU WERE HOPING TO GET INTO A 3106 02:04:23,625 --> 02:04:25,693 NOFO THAT'S NOT THERE, YOU HAVE 3107 02:04:25,693 --> 02:04:27,529 TO REALLY TRY TO LOOK AND SEE 3108 02:04:27,529 --> 02:04:35,236 WHICH IS THE BEST PARENT AWARD 3109 02:04:35,236 --> 02:04:38,039 THAT FITS YOUR SCIENCE SO 3110 02:04:38,039 --> 02:04:39,240 ENCOURAGING PEOPLE PARTICULARLY 3111 02:04:39,240 --> 02:04:42,644 WHO HAD DIVERSITY R01s OR ANY 3112 02:04:42,644 --> 02:04:44,646 OF THE DIVERSITY PROGRAMS TO 3113 02:04:44,646 --> 02:04:47,882 COME UNDER OF IN UNDER PARENT 3114 02:04:47,882 --> 02:04:50,051 AWARD REGULAR TRAINING OR R01 OR 3115 02:04:50,051 --> 02:04:50,351 R21. 3116 02:04:50,351 --> 02:04:52,320 THERE IS SOMETHING IMPORTANT TO 3117 02:04:52,320 --> 02:04:53,655 KNOW ABOUT, THE UPDATED PUBLIC 3118 02:04:53,655 --> 02:04:55,023 ACCESS POLICY OF THE NEW 3119 02:04:55,023 --> 02:04:55,690 ADMINISTRATION. 3120 02:04:55,690 --> 02:05:01,429 THIS WAS GOING TO GO IN EFFECT 3121 02:05:01,429 --> 02:05:04,933 LATER, BUT NOW IT'S NOW. 3122 02:05:04,933 --> 02:05:07,435 BY JULY 1, 2025, ALL THE 3123 02:05:07,435 --> 02:05:12,640 NIH-FUNDED RESEARCH MUST BE 3124 02:05:12,640 --> 02:05:14,776 SUBMITTED TO THE NATIONAL 3125 02:05:14,776 --> 02:05:16,044 LIBRARY OF MEDICINE PUBMED 3126 02:05:16,044 --> 02:05:17,812 CENTRAL, NO PERIOD OF EMBARGO IS 3127 02:05:17,812 --> 02:05:18,046 ALLOWED. 3128 02:05:18,046 --> 02:05:21,382 SO THIS WAS SOMETHING THAT NIH 3129 02:05:21,382 --> 02:05:22,584 WAS PLANNING TO DO. 3130 02:05:22,584 --> 02:05:24,953 THEY WERE INITIALLY THINKING OF 3131 02:05:24,953 --> 02:05:28,223 12-MONTH EMBARGO, BUT NOW THE 3132 02:05:28,223 --> 02:05:30,491 EMBARGO'S GONE SO ALL THESE 3133 02:05:30,491 --> 02:05:36,030 RESEARCH FROM NIH FUNDED HAS TO 3134 02:05:36,030 --> 02:05:41,369 GO INTO OPEN ACCESS. 3135 02:05:41,369 --> 02:05:41,836 OKAY. 3136 02:05:41,836 --> 02:05:47,508 YOU'RE GOING TO BE HEARING ABOUT 3137 02:05:47,508 --> 02:05:48,142 THE "HEAL" RESEARCH 3138 02:05:48,142 --> 02:05:49,344 RECOMMENDATIONS IN THE PAIN 3139 02:05:49,344 --> 02:05:50,278 SPACE COMING UP. 3140 02:05:50,278 --> 02:05:52,013 THERE IS I WANTED TO POINT YOU 3141 02:05:52,013 --> 02:05:53,781 TO THE ANNUAL REPORTS FROM THE 3142 02:05:53,781 --> 02:05:55,984 HEAL INITIATIVE IS NOW UP ON THE 3143 02:05:55,984 --> 02:05:56,251 WEBSITE. 3144 02:05:56,251 --> 02:05:59,787 AND THIS HAS THE COMPONENTS 3145 02:05:59,787 --> 02:06:01,322 RELATED TO REDUCING OPIOID 3146 02:06:01,322 --> 02:06:05,260 OVERDOSE DEATH AS WELL AS 3147 02:06:05,260 --> 02:06:06,461 IMPROVING PAIN CARE. 3148 02:06:06,461 --> 02:06:10,331 AS I MENTIONED, YEAH, THE HEAL 3149 02:06:10,331 --> 02:06:11,232 PAIN RECOMMENDATIONS COMING OUT 3150 02:06:11,232 --> 02:06:17,705 OF THE WORK GROUP CO-CHAIRED BY 3151 02:06:17,705 --> 02:06:22,210 ROB JARREAU AND KATHLEEN 3152 02:06:22,210 --> 02:06:29,384 INCLUDING -- SLUKA COMING FROM 3153 02:06:29,384 --> 02:06:29,584 THEM. 3154 02:06:29,584 --> 02:06:30,718 JACKIE WARD, THE FEDERAL 3155 02:06:30,718 --> 02:06:31,386 OFFICIAL RUNNING THIS GROUP WAS 3156 02:06:31,386 --> 02:06:37,625 LOST IN THE LAST COUPLE MONTHS. 3157 02:06:37,625 --> 02:06:38,726 THE TRIANNUAL REPORT, ANDY 3158 02:06:38,726 --> 02:06:40,428 MENTIONED THIS IS A REPORT 3159 02:06:40,428 --> 02:06:42,196 REQUIRED FOR THE COUNCIL TO 3160 02:06:42,196 --> 02:06:43,831 APPROVE EVERY YEAR, IT'S ABOUT 3161 02:06:43,831 --> 02:06:47,068 INCLUSION OF WOMEN AND 3162 02:06:47,068 --> 02:06:48,303 MINORITIES, PARTICIPANTS IN 3163 02:06:48,303 --> 02:06:50,338 CLINICAL RESEARCH, THE REPORT IS 3164 02:06:50,338 --> 02:06:53,041 IN THE ECB, THIS SLIDE JUST 3165 02:06:53,041 --> 02:06:56,044 INDICATES WHAT IS THE CHARGE TO 3166 02:06:56,044 --> 02:06:58,246 THE COUNCIL, AND CERTIFYING THIS 3167 02:06:58,246 --> 02:07:01,683 REPORT, AND JUST TO GIVE YOU A 3168 02:07:01,683 --> 02:07:02,483 GLIMPSE OF THE TAKEHOME DATA 3169 02:07:02,483 --> 02:07:06,487 THAT AT LEAST AS I PULLED IT OUT 3170 02:07:06,487 --> 02:07:09,190 IF ONE LOOKS AT SEX DIFFERENCES, 3171 02:07:09,190 --> 02:07:14,595 AS YOU CAN SEE OVER TIME, 3172 02:07:14,595 --> 02:07:15,296 MALE/FEMALE REPRESENTATION IN 3173 02:07:15,296 --> 02:07:18,333 OUR CLINICAL RESEARCH IS 3174 02:07:18,333 --> 02:07:23,638 PROBABLY CLOSE TO 50/50. 3175 02:07:23,638 --> 02:07:25,773 IN TERMS OF RACE, YOU CAN SEE 3176 02:07:25,773 --> 02:07:30,445 HERE IN TERMS OF THE AFRICAN 3177 02:07:30,445 --> 02:07:31,012 AMERICAN POPULATION IT IS 3178 02:07:31,012 --> 02:07:32,780 PROBABLY NOT -- A LITTLE BIT 3179 02:07:32,780 --> 02:07:36,651 BELOW WHERE IT SHOULD BE BUT 3180 02:07:36,651 --> 02:07:37,618 PRETTY CLOSE. 3181 02:07:37,618 --> 02:07:42,423 AND YOU CAN SEE THE ASIAN 3182 02:07:42,423 --> 02:07:43,725 POPULATION, AMERICAN INDIAN, 3183 02:07:43,725 --> 02:07:46,461 ALASKA NATIVE ALWAYS VERY LOW, 3184 02:07:46,461 --> 02:07:48,463 AND WHITES ABOUT 60%. 3185 02:07:48,463 --> 02:07:57,638 IF YOU LOOK AT ETHNICITY, I 3186 02:07:57,638 --> 02:07:58,339 THINK THAT THE HISPANIC 3187 02:07:58,339 --> 02:08:00,441 REPRESENTATION AGAIN KIND OF 3188 02:08:00,441 --> 02:08:02,009 GOVERNANCES UP AND DOWN 3189 02:08:02,009 --> 02:08:04,011 DEPENDING ON PROJECTS OPENING 3190 02:08:04,011 --> 02:08:05,380 AND CLOSING, AND THAT'S PROBABLY 3191 02:08:05,380 --> 02:08:07,582 A LITTLE BELOW WHERE WE SHOULD 3192 02:08:07,582 --> 02:08:10,785 BE, AND BUT I THINK ALL OUR 3193 02:08:10,785 --> 02:08:13,254 CLINICAL RESEARCH GROUPS ARE 3194 02:08:13,254 --> 02:08:14,689 TRYING TO GET POPULATION TO 3195 02:08:14,689 --> 02:08:22,663 STUDIES TO REPRESENT THE 3196 02:08:22,663 --> 02:08:23,364 AMERICAN POPULATION. 3197 02:08:23,364 --> 02:08:30,171 NEXT TO TALK ABOUT THE BROADER 3198 02:08:30,171 --> 02:08:30,938 NEUROSCIENCE RESEARCH ECOSYSTEM 3199 02:08:30,938 --> 02:08:33,107 AS I MENTIONED WE HAVE MORE 3200 02:08:33,107 --> 02:08:35,710 PEOPLE COMING INTO NEUROSCIENCE, 3201 02:08:35,710 --> 02:08:37,578 INTO NINDS, AND THIS HAS LED TO 3202 02:08:37,578 --> 02:08:41,048 A WHOLE HOST OF WHAT I WOULD 3203 02:08:41,048 --> 02:08:44,285 CALL INNOVATIVE SCIENCE, DR. 3204 02:08:44,285 --> 02:08:45,019 BHATTACHARYA MENTIONED, YOU 3205 02:08:45,019 --> 02:08:48,856 KNOW, THE NEED FOR THESE KIND OF 3206 02:08:48,856 --> 02:08:50,525 REALLY NEW IDEAS AND NEW LEVELS 3207 02:08:50,525 --> 02:08:53,461 THAT WE GET TO IN OUR SCIENCE. 3208 02:08:53,461 --> 02:08:55,997 THIS IS JUST A COMPILATION OF 3209 02:08:55,997 --> 02:08:57,865 PHOTOS FROM THE -- I HAD, YOU 3210 02:08:57,865 --> 02:08:59,534 KNOW, OUR STAFF PUT TOGETHER A 3211 02:08:59,534 --> 02:09:02,270 TOP TEN LIST, AS WE DO EVERY 3212 02:09:02,270 --> 02:09:04,405 YEAR, DOESN'T REALLY DO JUSTICE 3213 02:09:04,405 --> 02:09:06,941 TO ALL THE RESEARCH BUT EACH OF 3214 02:09:06,941 --> 02:09:09,444 THESE PROJECTS AND PLEASE GO TO 3215 02:09:09,444 --> 02:09:11,546 THE DIRECTOR'S PAGE IF YOU WANT 3216 02:09:11,546 --> 02:09:12,814 TO READ ABOUT THEM, I THINK 3217 02:09:12,814 --> 02:09:15,216 REALLY GET YOU TO ANOTHER LEVEL 3218 02:09:15,216 --> 02:09:18,152 OF UNDERSTANDING IN THESE 3219 02:09:18,152 --> 02:09:19,420 DIFFERENT FIELDS OF 3220 02:09:19,420 --> 02:09:20,087 NEUROSCIENCE. 3221 02:09:20,087 --> 02:09:21,622 SO, OUR INVESTIGATORS ARE DOING 3222 02:09:21,622 --> 02:09:24,091 GREAT WORK OUT THERE, AND IT'S 3223 02:09:24,091 --> 02:09:27,094 REALLY UP TO US TO USE THE 3224 02:09:27,094 --> 02:09:29,130 TAXPAYERS' FUNDS APPROPRIATED TO 3225 02:09:29,130 --> 02:09:32,567 US TO KEEP THAT GOING AND 3226 02:09:32,567 --> 02:09:34,735 ADVANCE IT EVEN FURTHER. 3227 02:09:34,735 --> 02:09:37,271 IN ADDITION TO THE SCIENCE THAT 3228 02:09:37,271 --> 02:09:38,473 YOU READ ABOUT, THERE'S ALSO A 3229 02:09:38,473 --> 02:09:41,442 LOT OF THINGS GOING ON THAT 3230 02:09:41,442 --> 02:09:42,043 PEOPLE DON'T KNOW THAT MUCH 3231 02:09:42,043 --> 02:09:44,078 ABOUT WHICH IS OUR TRANSLATIONAL 3232 02:09:44,078 --> 02:09:44,512 PROGRAM. 3233 02:09:44,512 --> 02:09:46,714 YOU KNOW, YEARS AGO WE PUT 3234 02:09:46,714 --> 02:09:48,783 TOGETHER A REALLY SOPHISTICATED 3235 02:09:48,783 --> 02:09:52,487 GROUP OF PEOPLE LED BY AMIR 3236 02:09:52,487 --> 02:09:55,556 TAVIZ COMING FROM CITY TO HELP 3237 02:09:55,556 --> 02:09:58,526 US MOVE DISCOVERIES AND EVENTS 3238 02:09:58,526 --> 02:10:01,362 TO ACTUAL TREATMENTS FOR PEOPLE, 3239 02:10:01,362 --> 02:10:02,230 FOR PATIENTS WITH NEUROLOGIC 3240 02:10:02,230 --> 02:10:04,098 DISORDERS, WHICH IS AS DR. 3241 02:10:04,098 --> 02:10:06,467 BHATTACHARYA SAID, THAT'S REALLY 3242 02:10:06,467 --> 02:10:08,703 WHAT THE POPULUS WANTS. 3243 02:10:08,703 --> 02:10:09,537 SO SMALL BUSINESS PROGRAMS, 3244 02:10:09,537 --> 02:10:12,406 WE'VE HAD A NUMBER OF PROJECTS. 3245 02:10:12,406 --> 02:10:14,742 THESE ARE ACTUALLY PROJECTS THAT 3246 02:10:14,742 --> 02:10:15,977 KEEP GETTING BETTER AND BETTER 3247 02:10:15,977 --> 02:10:16,978 EACH YEAR FROM THE SMALL 3248 02:10:16,978 --> 02:10:19,480 BUSINESS PROGRAM, ALSO FROM THE 3249 02:10:19,480 --> 02:10:22,750 NON-SBIR GRANTS, A NUMBER OF 3250 02:10:22,750 --> 02:10:25,820 PROJECTS THAT WE HAVE FUNDING, 3251 02:10:25,820 --> 02:10:28,489 DEEP BRAIN STIMULATION, YOU 3252 02:10:28,489 --> 02:10:35,630 KNOW, DEVELOPMENT OF NEW DRUGS, 3253 02:10:35,630 --> 02:10:36,597 TREATMENT FOR ALS, RARE 3254 02:10:36,597 --> 02:10:39,567 DISORDERS OF RARE FORMS OF ALS, 3255 02:10:39,567 --> 02:10:42,703 THESE ARE ALL THINGS THAT ARE 3256 02:10:42,703 --> 02:10:45,973 REALLY RIGHT AT THE CUSP OF 3257 02:10:45,973 --> 02:10:50,511 HELPING PEOPLE WITH REALLY TOUGH 3258 02:10:50,511 --> 02:10:50,978 PROBLEMS. 3259 02:10:50,978 --> 02:10:55,783 WE ALSO HAVE DONE SOME THINGS IN 3260 02:10:55,783 --> 02:10:56,751 THE REPRODUCIBILITY SPACE. 3261 02:10:56,751 --> 02:10:59,720 FOR YEARS RAN THE EPILEPSY 3262 02:10:59,720 --> 02:11:02,356 SCREENING PROGRAM NOW AT THE 3263 02:11:02,356 --> 02:11:04,292 UNIVERSITY OF UTAH RIGOROUSLY 3264 02:11:04,292 --> 02:11:06,594 LOOKING AT MULTIPLE DIFFERENT 3265 02:11:06,594 --> 02:11:07,228 EPILEPSY MODELS. 3266 02:11:07,228 --> 02:11:09,697 IT'S FREE TO BRING IN YOUR DRUG 3267 02:11:09,697 --> 02:11:12,066 TO SEE IF IT CAN PREVENT 3268 02:11:12,066 --> 02:11:13,234 EPILEPSY IN THESE MODELS. 3269 02:11:13,234 --> 02:11:14,635 AND YOU CAN GUARANTEE THAT THE 3270 02:11:14,635 --> 02:11:18,172 DATA COMING OUT OF THIS MODEL IS 3271 02:11:18,172 --> 02:11:19,574 REPRODUCIBLE AND RIGOROUS. 3272 02:11:19,574 --> 02:11:21,108 SO, ONE EXAMPLE IS SOMETHING IN 3273 02:11:21,108 --> 02:11:23,678 THIS SPACE WE'RE DOING FOR MANY 3274 02:11:23,678 --> 02:11:25,413 YEARS, THE SPAN NETWORK AND 3275 02:11:25,413 --> 02:11:28,649 STROKE IS ANOTHER EXAMPLE, AND 3276 02:11:28,649 --> 02:11:30,451 THEN THE PAIN PROGRAM WE HAVE IN 3277 02:11:30,451 --> 02:11:33,554 ANIMAL MODELS WITH PAIN IS 3278 02:11:33,554 --> 02:11:36,924 ANOTHER EXAMPLE OF THESE KIND OF 3279 02:11:36,924 --> 02:11:37,792 EFFORTS AND REPRODUCIBILITY OR 3280 02:11:37,792 --> 02:11:41,062 EFFORTS TO MAKE SURE THAT 3281 02:11:41,062 --> 02:11:41,629 EVERYTHING IS REPRODUCIBLE. 3282 02:11:41,629 --> 02:11:46,233 THE NUMBER OF OUR SCIENTISTS IN 3283 02:11:46,233 --> 02:11:52,273 THE INTRAMURAL PROGRAM HAVE DONE 3284 02:11:52,273 --> 02:12:02,116 OUTSTANDING WORK, RECOGNIZED, 3285 02:12:02,116 --> 02:12:07,855 INCLUDING AVI NAAT, JEFF 3286 02:12:07,855 --> 02:12:11,292 DIAMOND, ANTONINA AND LING-GANG 3287 02:12:11,292 --> 02:12:12,760 WU. 3288 02:12:12,760 --> 02:12:15,196 SOME EARLY-STAGE INVESTIGATORS, 3289 02:12:15,196 --> 02:12:20,568 SONIA SCHULTZ AND SADANYA 3290 02:12:20,568 --> 02:12:21,202 JACKSON NAMED PRESIDENTIAL 3291 02:12:21,202 --> 02:12:24,271 AWARDEES IN THE RECENT PAST, 3292 02:12:24,271 --> 02:12:26,307 GOOD EARLY STAGE FOLKS, NOT THAT 3293 02:12:26,307 --> 02:12:27,508 EARLY ANYMORE, BUT EARLIER THAT 3294 02:12:27,508 --> 02:12:30,378 WERE SOME OF THE OTHERS. 3295 02:12:30,378 --> 02:12:33,214 EARLIER THAN ME. 3296 02:12:33,214 --> 02:12:38,085 SO, I WANT TO END BY SAYING THAT 3297 02:12:38,085 --> 02:12:39,654 WE CAN'T DO WHAT WE HAVE DONE IN 3298 02:12:39,654 --> 02:12:41,555 THE PAST, AND ONE OF THE THINGS 3299 02:12:41,555 --> 02:12:45,326 WE TOOK REAL PRIDE IN IS 3300 02:12:45,326 --> 02:12:48,295 NON-PROFIT FORUM, BRINGING IN 3301 02:12:48,295 --> 02:12:49,063 THE DISEASE ORGANIZATIONS, FROM 3302 02:12:49,063 --> 02:12:51,699 70 TO 100, TO ALL MEET TOGETHER. 3303 02:12:51,699 --> 02:12:53,634 THEY PUT TOGETHER AN AGENDA FOR 3304 02:12:53,634 --> 02:12:55,102 THEM, WITH THEM, AND THEY 3305 02:12:55,102 --> 02:12:59,240 BENEFIT FROM IT. 3306 02:12:59,240 --> 02:13:00,007 WE BENEFIT FROM JOINING WITH 3307 02:13:00,007 --> 02:13:00,241 THEM. 3308 02:13:00,241 --> 02:13:02,076 COULDN'T DO IT THIS YEAR BUT, 3309 02:13:02,076 --> 02:13:04,445 BOY, WAS SO HAPPY THE AMERICAN 3310 02:13:04,445 --> 02:13:08,115 BRAIN COALITION, KATIE SALE AND 3311 02:13:08,115 --> 02:13:09,984 JEN FRENCH ALSO STEPPED UP TO 3312 02:13:09,984 --> 02:13:12,053 TAKE A LEADERSHIP IN ORGANIZING 3313 02:13:12,053 --> 02:13:13,487 THIS SO IT WILL GO ON AND IT'S 3314 02:13:13,487 --> 02:13:14,722 GOING TO BE EVEN BETTER THAN 3315 02:13:14,722 --> 02:13:16,624 EVER, AS I SAY EVERY YEAR. 3316 02:13:16,624 --> 02:13:20,194 AND IT'S GOING TO BE JUNE 25, AT 3317 02:13:20,194 --> 02:13:21,696 10:00 A.M., TO 4:00 P.M. 3318 02:13:21,696 --> 02:13:23,731 GOING TO BE RIGHT HERE IN THE 3319 02:13:23,731 --> 02:13:25,499 NEUROSCIENCE CENTER, IN THE 3320 02:13:25,499 --> 02:13:25,800 LARGER ROOM. 3321 02:13:25,800 --> 02:13:27,568 SO PLEASE COME TO THIS. 3322 02:13:27,568 --> 02:13:28,936 IT'S ALWAYS A GREAT MEETING, AND 3323 02:13:28,936 --> 02:13:39,413 IT WILL BE AGAIN THIS YEAR. 3324 02:13:42,083 --> 02:13:43,751 75 YEARS OF RESEARCH, 3325 02:13:43,751 --> 02:13:44,785 EXPLORATION, AND PROGRESS. 3326 02:13:44,785 --> 02:13:49,490 FOR THREE-QUARTERS OF A CENTURY 3327 02:13:49,490 --> 02:13:50,124 THE NIH'S NATIONAL INSTITUTE OF 3328 02:13:50,124 --> 02:13:50,691 NEUROLOGICAL DISORDERS AND 3329 02:13:50,691 --> 02:13:54,595 STROKE, NINDS, HAS BEEN AT THE 3330 02:13:54,595 --> 02:13:55,796 FOREFRONT OF NEUROSCIENCE 3331 02:13:55,796 --> 02:13:57,965 IMPROVING LIVES OF MILLIONS. 3332 02:13:57,965 --> 02:14:00,267 FROM PIONEERING NEUROLOGY 3333 02:14:00,267 --> 02:14:01,736 RESEARCH TO CRITICAL 3334 02:14:01,736 --> 02:14:02,803 BREAKTHROUGHS, NINDS HAS 3335 02:14:02,803 --> 02:14:05,005 RESHAPED HOW WE UNDERSTAND AND 3336 02:14:05,005 --> 02:14:07,074 TREAT NEUROLOGICAL DISORDERS. 3337 02:14:07,074 --> 02:14:08,542 FUELING ADVANCES THAT ONCE 3338 02:14:08,542 --> 02:14:10,377 SEEMED IMPOSSIBLE. 3339 02:14:10,377 --> 02:14:13,114 FROM LAB TO CLINIC, NINDS TURNS 3340 02:14:13,114 --> 02:14:14,615 RESEARCH INTO REAL WORLD 3341 02:14:14,615 --> 02:14:17,184 SOLUTIONS HELPING THOSE AFFECTED 3342 02:14:17,184 --> 02:14:17,752 BY NEUROLOGICAL DISORDERS. 3343 02:14:17,752 --> 02:14:20,554 DRIVEN BY A VISION TO UNLOCK THE 3344 02:14:20,554 --> 02:14:22,223 MYSTERIES OF THE BRAIN, NINDS 3345 02:14:22,223 --> 02:14:25,693 KNOWS THAT DISCOVERY IS BUILT ON 3346 02:14:25,693 --> 02:14:26,026 COLLABORATION. 3347 02:14:26,026 --> 02:14:27,661 THAT'S WHY WE WORK SIDE BY SIDE 3348 02:14:27,661 --> 02:14:30,431 WITH PEOPLE WHO HAVE LIVED 3349 02:14:30,431 --> 02:14:32,266 EXPERIENCE, THEIR INPUT GUIDES 3350 02:14:32,266 --> 02:14:33,434 RESEARCH PRIORITIES ENSURING 3351 02:14:33,434 --> 02:14:37,138 THAT WE'RE FOCUSED ON WHAT 3352 02:14:37,138 --> 02:14:37,772 MATTERS MOST. 3353 02:14:37,772 --> 02:14:40,508 NINDS ALSO SUPPORTS A THRIVING 3354 02:14:40,508 --> 02:14:42,009 COMMUNITY OF SCIENTISTS 3355 02:14:42,009 --> 02:14:43,577 INVESTING IN PEOPLE PUSHING 3356 02:14:43,577 --> 02:14:45,713 BOUNDARIES OF SCIENCE EVERY DAY, 3357 02:14:45,713 --> 02:14:46,747 THROUGH EVERY DISCOVERY AND 3358 02:14:46,747 --> 02:14:48,883 CLINICAL TRIAL NINDS HAS BECOME 3359 02:14:48,883 --> 02:14:51,352 A BEACON OF HOPE FOR PEOPLE 3360 02:14:51,352 --> 02:14:53,120 LIVING WITH NEUROLOGICAL 3361 02:14:53,120 --> 02:14:53,687 DISORDERS, BY ADVANCING 3362 02:14:53,687 --> 02:14:55,489 NEUROSCIENCE RESEARCH WE'RE 3363 02:14:55,489 --> 02:14:56,757 BUILDING A HEALTHIER, HAPPIER 3364 02:14:56,757 --> 02:14:57,958 FUTURE FOR ALL. 3365 02:14:57,958 --> 02:15:06,567 JOIN US IN SHAPING THE 3366 02:15:06,567 --> 02:15:07,168 THANKS VERY MUCH. 3367 02:15:07,168 --> 02:15:08,769 THAT'S OUR STORY. 3368 02:15:08,769 --> 02:15:18,779 WE'RE STICKING TO IT. 3369 02:15:18,779 --> 02:15:20,214 WE REALLY APPRECIATE IT. 3370 02:15:20,214 --> 02:15:22,650 I THINK WE'RE MOVING TO 3371 02:15:22,650 --> 02:15:30,491 QUESTIONS. 3372 02:15:30,491 --> 02:15:32,793 >> I HAVE A COMMENT, NOT A 3373 02:15:32,793 --> 02:15:33,060 QUESTION. 3374 02:15:33,060 --> 02:15:34,295 WALTER, I WANTED TO SAY THAT I'M 3375 02:15:34,295 --> 02:15:36,463 SURE I SPEAK FOR EVERYONE THAT 3376 02:15:36,463 --> 02:15:37,998 WE REALLY APPRECIATE THOSE OF 3377 02:15:37,998 --> 02:15:40,701 YOU AT NIH CONTINUING TO MOVE 3378 02:15:40,701 --> 02:15:41,735 FORWARD IN WAYS THAT INSPIRE US 3379 02:15:41,735 --> 02:15:43,370 TO CONTINUE TO DO WHAT WE DO AND 3380 02:15:43,370 --> 02:15:48,375 I JUST WANT TO SAY THANK YOU. 3381 02:15:48,375 --> 02:15:49,143 >> GREATLY APPRECIATED, HANK. 3382 02:15:49,143 --> 02:15:50,878 WE APPRECIATE THAT. 3383 02:15:50,878 --> 02:15:51,345 THANKS. 3384 02:15:51,345 --> 02:15:52,046 >> SECOND THAT. 3385 02:15:52,046 --> 02:15:55,049 YEAH, YOU GUYS KEEP US GOING 3386 02:15:55,049 --> 02:15:57,117 BECAUSE SOMETIMES, YOU KNOW, 3387 02:15:57,117 --> 02:15:58,519 IT'S EASY TO SAY, YOU KNOW, BUT 3388 02:15:58,519 --> 02:16:00,688 THANK YOU FOR ALL OF THE WORK 3389 02:16:00,688 --> 02:16:02,656 THAT YOU GUYS DO. 3390 02:16:02,656 --> 02:16:04,859 IT REALLY IS INSPIRING. 3391 02:16:04,859 --> 02:16:05,860 >> AMAZING, LOUISE, THE FIRST 3392 02:16:05,860 --> 02:16:08,796 NICE THING YOU EVER TOLD ME. 3393 02:16:08,796 --> 02:16:10,097 [LAUGHTER] 3394 02:16:10,097 --> 02:16:10,464 >> EVER SAID. 3395 02:16:10,464 --> 02:16:11,765 I STARTED DRINKING EARLY TODAY. 3396 02:16:11,765 --> 02:16:13,200 NO, BECAUSE SERIOUSLY OUT HERE 3397 02:16:13,200 --> 02:16:14,935 IN THE WORLD TRYING TO KEEP 3398 02:16:14,935 --> 02:16:16,670 THESE YOUNG PEOPLE FROM JUST 3399 02:16:16,670 --> 02:16:18,539 FREAKING OUT WITH ALL THE CHAOS, 3400 02:16:18,539 --> 02:16:19,840 YOU KNOW, JUST TRYING TO REALLY 3401 02:16:19,840 --> 02:16:26,647 KIND OF BE OPTIMISTIC, UPBEAT, 3402 02:16:26,647 --> 02:16:28,415 YOU'VE CHOSEN A GREAT CAREER 3403 02:16:28,415 --> 02:16:32,186 PATH, IT'S GREAT TO GET THAT 3404 02:16:32,186 --> 02:16:33,187 REINFORCED FROM YOU GUYS, 3405 02:16:33,187 --> 02:16:34,622 REINVIGORATES ME TO PUBLIC 3406 02:16:34,622 --> 02:16:41,562 HARDER TO TRY AND BE OPTIMISTIC 3407 02:16:41,562 --> 02:16:42,696 >> JIN MU? 3408 02:16:42,696 --> 02:16:46,066 >> I WANT TO THIRD THAT, WALTER. 3409 02:16:46,066 --> 02:16:47,868 I'M REALLY GLAD THAT YOU'RE AT 3410 02:16:47,868 --> 02:16:50,738 THE HELM DURING THIS REALLY 3411 02:16:50,738 --> 02:16:52,973 CHAOTIC TIME. 3412 02:16:52,973 --> 02:16:54,041 YOUR LEADERSHIP IS REALLY 3413 02:16:54,041 --> 02:16:54,508 APPRECIATED. 3414 02:16:54,508 --> 02:16:57,811 BUT I HAVE A QUESTION, IN 3415 02:16:57,811 --> 02:17:00,581 ADDITION TO THAT COMMENT. 3416 02:17:00,581 --> 02:17:02,216 I'M WONDERING IF YOU CAN TELL US 3417 02:17:02,216 --> 02:17:05,686 WHAT YOU THINK THE CONSEQUENCES 3418 02:17:05,686 --> 02:17:08,489 WILL BE OF MOVING REVIEW TO CSR. 3419 02:17:08,489 --> 02:17:11,492 I CAN UNDERSTAND THERE MIGHT BE 3420 02:17:11,492 --> 02:17:13,894 CERTAIN RFAs THAT REQUIRE 3421 02:17:13,894 --> 02:17:14,561 CERTAIN EXPERTISE FOR REVIEW, 3422 02:17:14,561 --> 02:17:17,965 BUT WHAT DO YOU THINK THE 3423 02:17:17,965 --> 02:17:20,301 CONSEQUENCES WILL BE FOR GRANTS 3424 02:17:20,301 --> 02:17:24,438 THAT ARE MIGRATING TO THE CSR? 3425 02:17:24,438 --> 02:17:26,774 >> WELL, YOU KNOW, YOGI BERRA 3426 02:17:26,774 --> 02:17:29,777 SAID IT'S HARD TO MAKE 3427 02:17:29,777 --> 02:17:30,544 PREDICTIONS, ESPECIALLY ABOUT 3428 02:17:30,544 --> 02:17:31,478 THE FUTURE. 3429 02:17:31,478 --> 02:17:34,081 BUT I THINK IT'S -- YOU KNOW, 3430 02:17:34,081 --> 02:17:36,050 JUST TO BE HONEST WHAT WE DIDN'T 3431 02:17:36,050 --> 02:17:41,622 SAY IS THAT IN THIS 3432 02:17:41,622 --> 02:17:43,223 CENTRALIZATION WHAT CSR DID IS 3433 02:17:43,223 --> 02:17:45,626 THEY TOOK ALL THE SROs FROM 3434 02:17:45,626 --> 02:17:46,727 THE INSTITUTES INTO CSR. 3435 02:17:46,727 --> 02:17:49,630 SO THEY ARE ALL MOVING SO THE 3436 02:17:49,630 --> 02:17:51,899 PEOPLE FROM OUR INSTITUTE HAVE A 3437 02:17:51,899 --> 02:17:53,734 LOT OF EXPERTISE IN THIS SPACE 3438 02:17:53,734 --> 02:17:57,538 WILL BE MOVING TO CSR, SO THERE 3439 02:17:57,538 --> 02:17:59,606 IS THE OPPORTUNITY IF THERE'S 3440 02:17:59,606 --> 02:18:02,042 TIME AND PLANNING ENOUGH FOR CSR 3441 02:18:02,042 --> 02:18:05,879 TO SET UP THE REVIEWS THAT 3442 02:18:05,879 --> 02:18:08,248 MIRROR WHAT WE HAD HERE WITH THE 3443 02:18:08,248 --> 02:18:10,551 PEOPLE WHO DID THEM HERE, AND I 3444 02:18:10,551 --> 02:18:12,353 THINK ALSO, YOU KNOW, OVER TIME 3445 02:18:12,353 --> 02:18:15,923 I THINK WE FIND OUT WHAT THE 3446 02:18:15,923 --> 02:18:20,160 BUGS ARE AND THEN WE WORK WITH 3447 02:18:20,160 --> 02:18:22,029 CSR TO IMPROVE THE REVIEWS. 3448 02:18:22,029 --> 02:18:26,734 SO I THINK, YOU KNOW, WE 3449 02:18:26,734 --> 02:18:27,968 DEFINITELY ARE NOT STARTING FROM 3450 02:18:27,968 --> 02:18:30,471 GROUND ZERO BECAUSE WE HAVE 3451 02:18:30,471 --> 02:18:32,740 THESE SROs WITH EXPERIENCE 3452 02:18:32,740 --> 02:18:34,408 MOVING IN, AND I THINK WE'LL 3453 02:18:34,408 --> 02:18:35,042 MAKE PROGRESS OVER TIME. 3454 02:18:35,042 --> 02:18:39,380 I THINK IN THE SHORT TERM, YOU 3455 02:18:39,380 --> 02:18:43,584 KNOW, UNFORTUNATELY FOR SOME OF 3456 02:18:43,584 --> 02:18:46,453 THESE BIGGER PROJECTS WE HERE AT 3457 02:18:46,453 --> 02:18:48,322 NINDS AND YOU AS COUNCIL MAY 3458 02:18:48,322 --> 02:18:52,292 NEED TO DIG IN DEEPER TO GIVE 3459 02:18:52,292 --> 02:18:54,461 GOOD RECOMMENDATIONS ON WHAT TO 3460 02:18:54,461 --> 02:18:54,661 FUND. 3461 02:18:54,661 --> 02:18:58,198 WE MAY NOT BE ABLE TO GO AND 3462 02:18:58,198 --> 02:19:00,334 SCORE ORDER AS MUCH AS WE IN THE 3463 02:19:00,334 --> 02:19:04,738 PAST FOR THESE KIND OF BIGGER 3464 02:19:04,738 --> 02:19:11,245 PROJECTS, PARTICULARLY THINGS 3465 02:19:11,245 --> 02:19:13,213 LIKE CLINICAL TRIALS, ANYTHING 3466 02:19:13,213 --> 02:19:16,483 THAT HAS PHASES, PARTICULARLY 3467 02:19:16,483 --> 02:19:17,918 TRADITIONAL THERAPY GRANTS, 3468 02:19:17,918 --> 02:19:18,385 BRAIN INITIATIVE, HEAL 3469 02:19:18,385 --> 02:19:20,254 INITIATIVE, IT WILL TAKE A 3470 02:19:20,254 --> 02:19:21,622 LITTLE MORE WORK ONCE REVIEW IS 3471 02:19:21,622 --> 02:19:25,192 DONE TO BE ABLE TO MAKE THE 3472 02:19:25,192 --> 02:19:25,559 RIGHT DECISIONS. 3473 02:19:25,559 --> 02:19:28,328 >> WALTER, CAN I ADD A COMMENT? 3474 02:19:28,328 --> 02:19:28,896 ANN HERE. 3475 02:19:28,896 --> 02:19:29,930 I WANTED TO ADD, YOU KNOW, IN 3476 02:19:29,930 --> 02:19:32,800 TERMS OF THE CONVERSATIONS WE'VE 3477 02:19:32,800 --> 02:19:36,603 BEEN HAVING WITH THE CENTER FOR 3478 02:19:36,603 --> 02:19:37,738 SCIENTIFIC REVIEW WE'VE RAISED 3479 02:19:37,738 --> 02:19:38,539 SOME CONCERNS THAT PEOPLE HAVE 3480 02:19:38,539 --> 02:19:39,940 HOW ARE WE GOING TO MAKE THE 3481 02:19:39,940 --> 02:19:41,675 RIGHT EXPERTS ARE ON THE REVIEW 3482 02:19:41,675 --> 02:19:43,210 PANEL, IF IT'S TRAINING GRANTS, 3483 02:19:43,210 --> 02:19:44,678 PUT INTO A GENERAL STUDY SECTION 3484 02:19:44,678 --> 02:19:48,682 HOW DO WE MAKE SURE THERE'S 3485 02:19:48,682 --> 02:19:51,351 NEUROLOGISTS AND NEUROSURGEONS 3486 02:19:51,351 --> 02:19:52,553 AND INTENSISTS WHO UNDERSTAND 3487 02:19:52,553 --> 02:19:54,755 THE CAREER PATH. 3488 02:19:54,755 --> 02:19:56,857 I WAS ASKED THE COMMUNITY TO 3489 02:19:56,857 --> 02:19:58,725 KEEP SIGNING UP FOR REVIEW WHEN 3490 02:19:58,725 --> 02:20:00,694 ASKED, THEY HAVE A ROSTER OF WHO 3491 02:20:00,694 --> 02:20:03,330 HAS BEEN ON OUR STUDY SECTIONS, 3492 02:20:03,330 --> 02:20:05,032 AND ARE LISTENING WHEN WE GIVE 3493 02:20:05,032 --> 02:20:05,299 FEEDBACK. 3494 02:20:05,299 --> 02:20:06,300 BACKUP THEY ARE ALSO ASKING FOR 3495 02:20:06,300 --> 02:20:08,268 FEEDBACK SO THIS IS NOT A TIME 3496 02:20:08,268 --> 02:20:10,003 TO BE QUIET. 3497 02:20:10,003 --> 02:20:11,538 BUT WE ABSOLUTELY NEED YOU TO 3498 02:20:11,538 --> 02:20:14,575 STEP UP OUR COLLEAGUES, WHO HAVE 3499 02:20:14,575 --> 02:20:19,480 BEEN SUCH WONDERFUL AND CAREFUL 3500 02:20:19,480 --> 02:20:20,180 REVIEWERS BECAUSE IT'S MORE 3501 02:20:20,180 --> 02:20:21,915 IMPORTANT IN THE COMING YEARS. 3502 02:20:21,915 --> 02:20:23,617 >> I FORGOT TO MENTION IN MY 3503 02:20:23,617 --> 02:20:26,854 TALK, WHICH I WANTED TO, IN 3504 02:20:26,854 --> 02:20:33,794 TERMS OF REVIEW, FOR SOME REASON 3505 02:20:33,794 --> 02:20:36,396 THE NEED FOR FOREIGN 3506 02:20:36,396 --> 02:20:38,265 JUSTIFICATION IN A GRANT HAS 3507 02:20:38,265 --> 02:20:42,736 GONE UP A COUPLE NOTCHES. 3508 02:20:42,736 --> 02:20:47,141 SO A NUMBER OF GRANTS HAVE BEEN 3509 02:20:47,141 --> 02:20:50,277 WITHDRAWN BECAUSE DID NOT HAVE A 3510 02:20:50,277 --> 02:20:52,246 FOREIGN JUSTIFICATION PIECE IN 3511 02:20:52,246 --> 02:20:55,916 THE GRANT, THE FOGARTY WHICH 3512 02:20:55,916 --> 02:20:56,783 ONLY DOES INTERNATIONAL GRANTS 3513 02:20:56,783 --> 02:20:57,818 HAD 35% OF THE GRANTS WITHDRAWN 3514 02:20:57,818 --> 02:21:01,522 BECAUSE THEY DIDN'T HAVE A 3515 02:21:01,522 --> 02:21:02,122 FOREIGN JUSTIFICATION. 3516 02:21:02,122 --> 02:21:03,323 THESE ARE PEOPLE WHO BASICALLY A 3517 02:21:03,323 --> 02:21:04,424 FOREIGN GRANT, I GUESS THEY 3518 02:21:04,424 --> 02:21:06,360 DIDN'T THINK THEY NEEDED TO PUT 3519 02:21:06,360 --> 02:21:07,461 THAT IN. 3520 02:21:07,461 --> 02:21:09,396 THE WHOLE THING WAS A FOREIGN 3521 02:21:09,396 --> 02:21:10,731 JUSTIFICATION. 3522 02:21:10,731 --> 02:21:12,566 BUT EVEN ON OUR END, PEOPLE WHO 3523 02:21:12,566 --> 02:21:15,102 HAD A COLLABORATOR IN ANOTHER 3524 02:21:15,102 --> 02:21:19,273 COUNTRY WASN'T EVEN GETTING ANY 3525 02:21:19,273 --> 02:21:20,374 FUNDING, WERE WITHDRAWN BECAUSE 3526 02:21:20,374 --> 02:21:22,442 THEY DIDN'T MENTION THAT IN THE 3527 02:21:22,442 --> 02:21:26,380 FOREIGN JUSTIFICATION. 3528 02:21:26,380 --> 02:21:29,983 SO ANYBODY YOU SEE, ANY KIND -- 3529 02:21:29,983 --> 02:21:32,686 ANYTHING FOREIGN PIECE OF WORK 3530 02:21:32,686 --> 02:21:36,323 OR COLLABORATOR OR WE HAD ONE 3531 02:21:36,323 --> 02:21:36,924 WHERE A COMPANY INDICATED 3532 02:21:36,924 --> 02:21:38,759 INTEREST IN THE RESEARCH AND THE 3533 02:21:38,759 --> 02:21:40,394 COMPANY WAS IN ANOTHER COUNTRY, 3534 02:21:40,394 --> 02:21:42,129 ALL THOSE KINDS OF THINGS NOW 3535 02:21:42,129 --> 02:21:45,332 YOU NEED A FOREIGN JUSTIFICATION 3536 02:21:45,332 --> 02:21:47,000 FOR IT, FOR WITHDRAWING THE 3537 02:21:47,000 --> 02:21:48,302 GRANTS. 3538 02:21:48,302 --> 02:21:58,779 PLEASE SPREAD THAT MESSAGE. 3539 02:22:02,816 --> 02:22:02,983 FRANCES? 3540 02:22:02,983 --> 02:22:05,085 >> YEAH, AGAIN, HEARTFELT THANKS 3541 02:22:05,085 --> 02:22:08,755 FROM THE ACADEMIC COMMUNITY FOR 3542 02:22:08,755 --> 02:22:12,092 EVERYTHING THAT YOU ARE 3543 02:22:12,092 --> 02:22:13,193 PRESERVING FOR US AND INNOVATING 3544 02:22:13,193 --> 02:22:15,262 THROUGH THESE CHALLENGING TIMES. 3545 02:22:15,262 --> 02:22:20,067 TO THAT POINT, I'M WONDERING 3546 02:22:20,067 --> 02:22:22,402 LISTENING TO DR. BHATTACHARYA'S 3547 02:22:22,402 --> 02:22:23,170 PRESENTATION, HE MENTIONED 3548 02:22:23,170 --> 02:22:27,274 SEVERAL TIMES HE FELT THE NINDS 3549 02:22:27,274 --> 02:22:30,177 WAS WORKING IN A SPACE WITH 3550 02:22:30,177 --> 02:22:32,980 EMPHASIS ON CHRONIC DISEASE THAT 3551 02:22:32,980 --> 02:22:35,749 HAS BEEN PRIORITIZED BY HIM AND 3552 02:22:35,749 --> 02:22:36,617 THE ADMINISTRATION. 3553 02:22:36,617 --> 02:22:40,187 I'M WONDERING TO WHAT EXTENT WE 3554 02:22:40,187 --> 02:22:45,459 CAN REALLY CREATE A VERY EASY TO 3555 02:22:45,459 --> 02:22:47,561 UNDERSTAND NARRATIVE ABOUT HOW 3556 02:22:47,561 --> 02:22:48,595 THE RESEARCH BEING DONE ON THE 3557 02:22:48,595 --> 02:22:50,497 BRAIN AND GIVEN THAT 3558 02:22:50,497 --> 02:22:53,000 NEUROLOGICAL AND PSYCHIATRIC 3559 02:22:53,000 --> 02:22:54,735 DISEASES ARE PROBABLY AN 3560 02:22:54,735 --> 02:22:57,404 AGGREGATE, THE HIGHEST SINGLE 3561 02:22:57,404 --> 02:22:58,405 CAUSE OF DISABILITY ADJUSTED 3562 02:22:58,405 --> 02:22:59,973 LIFE YEARS, FRANKLY ALMOST LIKE 3563 02:22:59,973 --> 02:23:02,476 100% CHANCE IN A LIFESPAN YOU'LL 3564 02:23:02,476 --> 02:23:06,680 HAVE SOME KIND OF 3565 02:23:06,680 --> 02:23:07,214 NEUROPSYCHIATRIC DISORDER, 3566 02:23:07,214 --> 02:23:08,782 WHETHER WE SHOULD BE WORKING 3567 02:23:08,782 --> 02:23:12,152 HARD TO MAKE IT RELATABLE, 3568 02:23:12,152 --> 02:23:14,488 UNDERSTANDABLE, THAT THIS FITS 3569 02:23:14,488 --> 02:23:16,657 WITH THE MAKE AMERICA HEALTHY 3570 02:23:16,657 --> 02:23:17,758 AGAIN KIND OF MANDATE AND WHERE 3571 02:23:17,758 --> 02:23:20,627 WE ARE IN THAT SPACE BECAUSE I 3572 02:23:20,627 --> 02:23:23,163 THINK WE ARE ACROSS THE LIFESPAN 3573 02:23:23,163 --> 02:23:25,332 FROM EARLY LIFE WE HEAR ABOUT 3574 02:23:25,332 --> 02:23:26,733 THE INTEREST IN AUTISM, TO 3575 02:23:26,733 --> 02:23:28,935 DEMENTIA, AND EVERYTHING IN 3576 02:23:28,935 --> 02:23:31,138 BETWEEN, WE'RE REALLY RIGHT 3577 02:23:31,138 --> 02:23:31,338 THERE. 3578 02:23:31,338 --> 02:23:35,475 AND THE BRAIN IS FRANKLY THE 3579 02:23:35,475 --> 02:23:36,877 MOST COMPLEX ORGAN SYSTEM IN THE 3580 02:23:36,877 --> 02:23:42,582 BODY AND IS SORT OF THE ONE IN 3581 02:23:42,582 --> 02:23:43,684 WHICH OUR SOCIETY IS INCREASING 3582 02:23:43,684 --> 02:23:46,753 DEPENDING ON, THE LAST FRONTIER 3583 02:23:46,753 --> 02:23:47,754 FOR THE MID-21ST CENTURY 3584 02:23:47,754 --> 02:23:52,793 SCIENCE, HOW WE CAN GET THAT 3585 02:23:52,793 --> 02:23:56,296 NARRATIVE ACROSS IN A RELATABLE 3586 02:23:56,296 --> 02:24:01,535 AND TRUSTWORTHY WAY TO THED A -- 3587 02:24:01,535 --> 02:24:05,605 TO THE ADVOCATES WE NEED TO 3588 02:24:05,605 --> 02:24:06,807 COMMUNICATE WITH. 3589 02:24:06,807 --> 02:24:09,943 >> WELL, SO I CAN'T ADVOCATE, 3590 02:24:09,943 --> 02:24:18,251 BUT I THINK YOU MADE TREMENDOUS 3591 02:24:18,251 --> 02:24:18,485 POINTS. 3592 02:24:18,485 --> 02:24:22,155 AND I THINK THAT THE ISSUE IS, 3593 02:24:22,155 --> 02:24:25,525 YOU KNOW, HOW DO WE MORE 3594 02:24:25,525 --> 02:24:28,161 EFFECTIVELY GIVE THOSE -- GET 3595 02:24:28,161 --> 02:24:29,096 THAT MESSAGE ACROSS -- 3596 02:24:29,096 --> 02:24:31,131 >> I DIDN'T MEAN ADVOCATE IN THE 3597 02:24:31,131 --> 02:24:32,899 TYPICAL, YOU KNOW, LEGAL FORM OF 3598 02:24:32,899 --> 02:24:33,967 ADVOCACY. 3599 02:24:33,967 --> 02:24:36,236 I MEANT IN CREATING AND 3600 02:24:36,236 --> 02:24:37,904 EXPLAINING WHAT WE DO. 3601 02:24:37,904 --> 02:24:38,305 >> YEAH. 3602 02:24:38,305 --> 02:24:43,477 YEAH, NO, BUT I WAS GOING TO SAY 3603 02:24:43,477 --> 02:24:44,778 THAT YOU COULD TAKE SOME 3604 02:24:44,778 --> 02:24:47,347 EXCEPTION TO THE DATA THAT JAY 3605 02:24:47,347 --> 02:24:52,185 PRESENTED BUT I THINK THE TRUTH 3606 02:24:52,185 --> 02:24:53,387 IS THE -- THERE IS THIS 3607 02:24:53,387 --> 02:24:54,554 IMPRESSION THE AMERICAN PEOPLE 3608 02:24:54,554 --> 02:24:57,624 DON'T UNDERSTAND THE VALUE OF 3609 02:24:57,624 --> 02:25:00,927 THE RESEARCH WE DO. 3610 02:25:00,927 --> 02:25:04,431 AND SO THAT WOULD BE THE END OF 3611 02:25:04,431 --> 02:25:06,266 NIH BECAUSE, YOU KNOW, THE 3612 02:25:06,266 --> 02:25:07,801 TAXPAYERS' INVESTMENT IS WHAT 3613 02:25:07,801 --> 02:25:09,069 WE'RE WORKING OFF OF. 3614 02:25:09,069 --> 02:25:14,541 SO HOW TO GET THAT MESSAGE OUT, 3615 02:25:14,541 --> 02:25:18,044 I THINK DR. BHATTACHARYA -- I 3616 02:25:18,044 --> 02:25:19,913 THINK HE BUY INTO THE BRAIN 3617 02:25:19,913 --> 02:25:20,514 DISORDER ISSUES. 3618 02:25:20,514 --> 02:25:22,115 HE'S GOT HIS OWN ISSUES BUT, YOU 3619 02:25:22,115 --> 02:25:24,117 KNOW, I THINK THAT THE PEOPLE 3620 02:25:24,117 --> 02:25:26,119 CAN MAKE THE DIFFERENCE, REALLY 3621 02:25:26,119 --> 02:25:30,757 THE PATIENT GROUPS OUT THERE, 3622 02:25:30,757 --> 02:25:33,093 AND RECALL THAT EVERYTHING IS 3623 02:25:33,093 --> 02:25:34,961 REALLY DETERMINED BY THE BUDGET. 3624 02:25:34,961 --> 02:25:36,029 EVERYTHING THAT'S BEEN GOING ON 3625 02:25:36,029 --> 02:25:40,267 HERE HAS BEEN MORE KIND OF LIKE 3626 02:25:40,267 --> 02:25:41,835 THE INNER WORKINGS AND THE 3627 02:25:41,835 --> 02:25:44,304 MACHINE, BUT IT'S THE BUDGET 3628 02:25:44,304 --> 02:25:45,338 THAT REALLY MATTERS. 3629 02:25:45,338 --> 02:25:47,874 AND THAT'S WHERE THE MESSAGE HAS 3630 02:25:47,874 --> 02:25:51,511 TO COME FROM TRUSTED SOURCES TO 3631 02:25:51,511 --> 02:25:53,346 THE CONGRESS. 3632 02:25:53,346 --> 02:25:54,381 AND THAT'S SOMETHING, AS I SAID, 3633 02:25:54,381 --> 02:25:57,117 WE CAN'T DO THAT. 3634 02:25:57,117 --> 02:25:59,786 WE CAN'T DO THAT AND -- BUT 3635 02:25:59,786 --> 02:26:01,488 THAT'S WHAT EVERYTHING RELIES 3636 02:26:01,488 --> 02:26:02,522 ON. 3637 02:26:02,522 --> 02:26:06,960 SO I CERTAINLY APPRECIATE ALL 3638 02:26:06,960 --> 02:26:09,830 THAT ANA HAS DONE, BRAIN ATTACK 3639 02:26:09,830 --> 02:26:11,665 COALITION, DIFFERENT SOCIETIES, 3640 02:26:11,665 --> 02:26:13,300 SOCIETIES FOR NEUROSCIENCE BUT 3641 02:26:13,300 --> 02:26:18,472 WE'RE PROBABLY LOSING THE BATTLE 3642 02:26:18,472 --> 02:26:21,508 RIGHT NOW. 3643 02:26:21,508 --> 02:26:25,712 >> IN TERMS OF OUR PROPOSAL 3644 02:26:25,712 --> 02:26:30,317 AWARD, PROPOSAL -- OUR RESEARCH 3645 02:26:30,317 --> 02:26:31,985 PROGRAMS MAYBE EMPHASIZING 3646 02:26:31,985 --> 02:26:34,221 RELATIONSHIP TO THE PRIORITIES 3647 02:26:34,221 --> 02:26:37,157 THAT THE ADMINISTRATION HAS 3648 02:26:37,157 --> 02:26:38,158 ALREADY CHOSEN, I'M FEELING 3649 02:26:38,158 --> 02:26:41,061 THERE'S SO MUCH THAT'S SO 3650 02:26:41,061 --> 02:26:44,531 NATURALLY TRANSFERABLE TO THOSE 3651 02:26:44,531 --> 02:26:45,832 KIND OF MANDATES THAT, YOU KNOW, 3652 02:26:45,832 --> 02:26:49,436 WE SHOULD WORK ON AS A COMMUNITY 3653 02:26:49,436 --> 02:26:51,037 REPRESENTING NINDS AND THINKING 3654 02:26:51,037 --> 02:26:53,440 ABOUT THE ACTUAL TYPES OF 3655 02:26:53,440 --> 02:26:55,976 GRANTS, THE AWARD MECHANISMS IN 3656 02:26:55,976 --> 02:26:58,778 FACT THAT COULD POTENTIALLY BE 3657 02:26:58,778 --> 02:27:01,848 NEW OPPORTUNITIES FOR US TO GROW 3658 02:27:01,848 --> 02:27:04,885 RATHER THAN SHRINK IN SOME 3659 02:27:04,885 --> 02:27:05,752 AREAS. 3660 02:27:05,752 --> 02:27:07,821 >> I TOTALLY AGREE, YEAH. 3661 02:27:07,821 --> 02:27:08,455 >> I'M NEXT. 3662 02:27:08,455 --> 02:27:10,323 I HAVE A QUESTION ABOUT THE 3663 02:27:10,323 --> 02:27:14,861 BUDGET BUT FIRST IN RELATION TO 3664 02:27:14,861 --> 02:27:17,697 WHAT FRANCES WAS SAYING GETTING 3665 02:27:17,697 --> 02:27:19,366 THE WORD OUT FALLS UPON ALL OF 3666 02:27:19,366 --> 02:27:20,333 US, SCIENTISTS AND COMMUNITIES 3667 02:27:20,333 --> 02:27:21,468 WE'RE PART OF. 3668 02:27:21,468 --> 02:27:22,769 THAT MEANS RESEARCH COMMUNITIES 3669 02:27:22,769 --> 02:27:24,104 AND PATIENT GROUPS THAT WE WORK 3670 02:27:24,104 --> 02:27:24,771 WITH. 3671 02:27:24,771 --> 02:27:27,040 LAST WEEK I WAS WITH ALL THE 3672 02:27:27,040 --> 02:27:29,075 ADRC DIRECTORS AND WE SAID WE'VE 3673 02:27:29,075 --> 02:27:30,744 NOT DONE A GOOD JOB SHOWING WHY 3674 02:27:30,744 --> 02:27:33,580 WHAT WE DO MAKES A DIFFERENCE. 3675 02:27:33,580 --> 02:27:34,848 ALSO BRINGING IN OUR RESEARCH 3676 02:27:34,848 --> 02:27:35,916 PARTICIPANTS TO MAKE THAT POINT 3677 02:27:35,916 --> 02:27:37,050 AS WELL. 3678 02:27:37,050 --> 02:27:38,351 SO, YES, WE HAVE TO DO THAT. 3679 02:27:38,351 --> 02:27:40,887 THE QUESTION ABOUT THE BUDGET, 3680 02:27:40,887 --> 02:27:41,788 YOU MENTIONED, WALTER, SOME 3681 02:27:41,788 --> 02:27:43,123 DOORS ARE OFF THE PLANE. 3682 02:27:43,123 --> 02:27:46,359 IF THERE'S A 40% REDUCTION IN 3683 02:27:46,359 --> 02:27:47,861 NIH BUDGET, A WING IS OFF THE 3684 02:27:47,861 --> 02:27:49,195 PLANE, FOR SURE. 3685 02:27:49,195 --> 02:27:51,398 SO IT'S HARD TO EVEN THINK ABOUT 3686 02:27:51,398 --> 02:27:51,731 THAT. 3687 02:27:51,731 --> 02:27:54,601 AND SO ONE OF MY QUESTIONS FOR 3688 02:27:54,601 --> 02:27:55,969 YOU IS I REALLY APPRECIATE YOUR 3689 02:27:55,969 --> 02:27:57,704 PLANS TO BE CAUTIOUS ABOUT NOT 3690 02:27:57,704 --> 02:27:59,773 OVERSPENDING RIGHT NOW BUT ALSO 3691 02:27:59,773 --> 02:28:01,741 HAVING WAYS TO TAKE BLOCKS OF 3692 02:28:01,741 --> 02:28:03,977 12, YOU KNOW, THREE YEARS OF 3693 02:28:03,977 --> 02:28:05,979 FUNDING SO YOU CAN ACTUALLY 3694 02:28:05,979 --> 02:28:06,780 COMMIT SOME MONIES NOW. 3695 02:28:06,780 --> 02:28:08,515 IF WE GET TO THE POINT BECAUSE 3696 02:28:08,515 --> 02:28:11,084 OF THE SLOW ROLLING OF AWARDS 3697 02:28:11,084 --> 02:28:13,186 THAT WE HAVEN'T SPENT OUT OUR 3698 02:28:13,186 --> 02:28:15,155 BUDGET IN THIS YEAR, WILL THAT 3699 02:28:15,155 --> 02:28:17,090 BE USED AS JUSTIFICATION BY 3700 02:28:17,090 --> 02:28:18,258 POLITICIANS THAT WE DIDN'T NEED 3701 02:28:18,258 --> 02:28:19,526 THE MONEY BECAUSE WE DIDN'T 3702 02:28:19,526 --> 02:28:20,360 SPEND IT? 3703 02:28:20,360 --> 02:28:22,562 SO IS THAT SOMETHING THAT YOU 3704 02:28:22,562 --> 02:28:25,565 THINK OF IN HOW YOU MIGHT ADJUST 3705 02:28:25,565 --> 02:28:26,566 YOUR PAY PLANS ACCORDINGLY TO 3706 02:28:26,566 --> 02:28:32,606 ENSURE THAT WE SPEND WHAT WE 3707 02:28:32,606 --> 02:28:33,440 CAN? 3708 02:28:33,440 --> 02:28:37,510 >> SO IF CHRISTINE LAMB IS HERE, 3709 02:28:37,510 --> 02:28:38,712 TELL US. 3710 02:28:38,712 --> 02:28:40,880 SO EVERY YEAR, WE RETURN 3711 02:28:40,880 --> 02:28:44,417 SOMEWHERE BETWEEN A DOLLAR AND A 3712 02:28:44,417 --> 02:28:44,918 DOLLAR-FIFTY. 3713 02:28:44,918 --> 02:28:45,352 AND WE -- 3714 02:28:45,352 --> 02:28:47,587 >> WELL, THAT'S GOOD. 3715 02:28:47,587 --> 02:28:49,556 >> NOT TO GO OVER THAT. 3716 02:28:49,556 --> 02:28:51,658 YEAH, KNOW, BUT I THINK TO THE 3717 02:28:51,658 --> 02:28:53,693 POINT THAT'S WHERE THE 3718 02:28:53,693 --> 02:28:55,629 MULTI-YEAR FUNDING WILL BE USED, 3719 02:28:55,629 --> 02:29:00,000 SO THAT WE DON'T SEND -- WE USE 3720 02:29:00,000 --> 02:29:08,208 ALL THE MONEY APPROPRIATED BUT 3721 02:29:08,208 --> 02:29:09,976 THEN PROTECTED NEXT YEAR. 3722 02:29:09,976 --> 02:29:10,310 EXACTLY RIGHT. 3723 02:29:10,310 --> 02:29:11,277 DOES CHRISTINE REMEMBER HOW MUCH 3724 02:29:11,277 --> 02:29:13,380 WE RETURNED LAST YEAR? 3725 02:29:13,380 --> 02:29:14,414 OH, SHE'S NOT HERE, OKAY. 3726 02:29:14,414 --> 02:29:18,418 WE'LL LET YOU KNOW, BUT IT'S 3727 02:29:18,418 --> 02:29:18,685 TINY. 3728 02:29:18,685 --> 02:29:23,223 WE HAVE A GREAT BUDGET OFFICE. 3729 02:29:23,223 --> 02:29:29,829 >> SHE'S ON. 3730 02:29:29,829 --> 02:29:30,430 >> HI. 3731 02:29:30,430 --> 02:29:31,798 YEAH, WE WILL WORK DILIGENTLY 3732 02:29:31,798 --> 02:29:32,799 WITH PROGRAM AND GRANTS 3733 02:29:32,799 --> 02:29:34,734 MANAGEMENT TO SPEND EVERY DOLLAR 3734 02:29:34,734 --> 02:29:38,905 WE'RE ABLE TO BEFORE THE YEAR 3735 02:29:38,905 --> 02:29:39,472 LAPSE. 3736 02:29:39,472 --> 02:29:40,640 THAT'S OUR MISSION, MORE SO THIS 3737 02:29:40,640 --> 02:29:41,541 YEAR THAN EVER BEFORE. 3738 02:29:41,541 --> 02:29:43,043 >> THANK YOU. 3739 02:29:43,043 --> 02:29:45,078 WE APPRECIATE THAT. 3740 02:29:45,078 --> 02:29:45,345 >> BOB? 3741 02:29:45,345 --> 02:29:46,379 >> YEAH, I'LL BE BRIEF. 3742 02:29:46,379 --> 02:29:47,714 A COMMENT AND QUESTION. 3743 02:29:47,714 --> 02:29:50,483 I TOO WANT TO FIFTH OR SIXTH OR 3744 02:29:50,483 --> 02:29:52,986 WHATEVER ORDER PLUG YOU FOR WHAT 3745 02:29:52,986 --> 02:29:54,220 YOU'VE DONE, A PHENOMENAL 3746 02:29:54,220 --> 02:29:55,522 LEADER, WALTER. 3747 02:29:55,522 --> 02:29:56,623 DEEPLY GRATEFUL. 3748 02:29:56,623 --> 02:29:57,624 IT'S INTRIGUING, I LOOKED AT 3749 02:29:57,624 --> 02:30:00,193 SOME NUMBERS WITH EMILY AS WE 3750 02:30:00,193 --> 02:30:01,928 GOT CLOSER TO THE 75th 3751 02:30:01,928 --> 02:30:04,798 CELEBRATION, THAT SINCE ITS 3752 02:30:04,798 --> 02:30:07,701 INCEPTION IN 19 50 NINDS HAS 3753 02:30:07,701 --> 02:30:10,770 SPENT $55 BILLION TOWARD 3754 02:30:10,770 --> 02:30:14,007 IMPROVING AMERICAN HEALTH AND 3755 02:30:14,007 --> 02:30:15,975 NEUROLOGIC DISORDERS, THE IMPACT 3756 02:30:15,975 --> 02:30:21,748 IS IMMENSE, RAISING THE ALREADY 3757 02:30:21,748 --> 02:30:23,783 BROUGHT ABOUT UP ENORMOUS IMPACT 3758 02:30:23,783 --> 02:30:25,151 READILY VIEWABLE AND ACCESSIBLE 3759 02:30:25,151 --> 02:30:26,453 TO NOT ONLY THE PUBLIC BUT 3760 02:30:26,453 --> 02:30:28,388 PEOPLE WHO MAKE DECISIONS IN 3761 02:30:28,388 --> 02:30:28,655 CONGRESS. 3762 02:30:28,655 --> 02:30:30,390 SOMEHOW WE'VE DROPPED THE BALL 3763 02:30:30,390 --> 02:30:33,293 IN THE WAY WE CAN PROMOTE WHAT 3764 02:30:33,293 --> 02:30:34,494 GREAT ACCOMPLISHMENTS THERE HAVE 3765 02:30:34,494 --> 02:30:37,197 BEEN IN THE NINDS. 3766 02:30:37,197 --> 02:30:38,631 CAN YOU TELL US, MUCH MORE 3767 02:30:38,631 --> 02:30:42,202 GRANULAR, BUT WHAT ARE THE STEPS 3768 02:30:42,202 --> 02:30:44,104 WHEREBY THE DEFICIT OR 40% 3769 02:30:44,104 --> 02:30:45,105 REDUCTION WILL FINALLY BE 3770 02:30:45,105 --> 02:30:46,072 ADDRESSED? 3771 02:30:46,072 --> 02:30:47,941 EVERY DAY IN OUR DISCUSSIONS IN 3772 02:30:47,941 --> 02:30:49,709 THE LABORATORIES AT HOME, THIS 3773 02:30:49,709 --> 02:30:51,277 QUESTION COMES UP, WHAT ARE THE 3774 02:30:51,277 --> 02:30:53,079 NEXT STEPS, WHAT CAN WE DO IF 3775 02:30:53,079 --> 02:30:55,615 ANYTHING, AT THIS STAGE, TO 3776 02:30:55,615 --> 02:30:56,216 INFLUENCE THE FINAL DECISION 3777 02:30:56,216 --> 02:31:02,622 MAKING ON THE DEGREE OF THE 3778 02:31:02,622 --> 02:31:04,824 REDUCTION? 3779 02:31:04,824 --> 02:31:09,763 >> I COULD JUST TALK TO THE 3780 02:31:09,763 --> 02:31:09,996 PROCESS. 3781 02:31:09,996 --> 02:31:11,064 YOU KNOW -- THERE'S A HOUSE 3782 02:31:11,064 --> 02:31:13,133 BUDGET AND THERE'S A PRESIDENT'S 3783 02:31:13,133 --> 02:31:14,634 BUDGET, AND THEN THERE'S A 3784 02:31:14,634 --> 02:31:18,705 SENATE, AND THEN THERE'S A 3785 02:31:18,705 --> 02:31:19,005 COMPROMISE. 3786 02:31:19,005 --> 02:31:21,341 AND SO THIS YEAR THE HOUSE 3787 02:31:21,341 --> 02:31:23,977 BUDGET AND PRESIDENT'S BUDGET 3788 02:31:23,977 --> 02:31:28,848 LOOK PRETTY IDENTICAL WITH A 40% 3789 02:31:28,848 --> 02:31:29,015 CUT. 3790 02:31:29,015 --> 02:31:31,985 AND ALSO RECALL THE HOUSE BUDGET 3791 02:31:31,985 --> 02:31:36,389 FROM LAST YEAR WHICH WAS NOT 3792 02:31:36,389 --> 02:31:38,625 ENACTED, ALSO CALLED FOR 3793 02:31:38,625 --> 02:31:42,762 CONSOLIDATION OF MULTIPLE 3794 02:31:42,762 --> 02:31:43,229 INSTITUTES. 3795 02:31:43,229 --> 02:31:46,566 AND SO I THINK WHAT HAPPENS NEXT 3796 02:31:46,566 --> 02:31:48,101 IS THE SENATE HAS TO SIT DOWN 3797 02:31:48,101 --> 02:31:51,271 WITH THE HOUSE AND IRON OUT A 3798 02:31:51,271 --> 02:31:51,571 COMPROMISE. 3799 02:31:51,571 --> 02:31:54,340 IN THE PAST THE HOUSE BUDGET WAS 3800 02:31:54,340 --> 02:31:56,342 ALWAYS LOWER, SENATE BUDGET WAS 3801 02:31:56,342 --> 02:31:59,312 HIGHER, WE GOT SOMEWHERE IN THE 3802 02:31:59,312 --> 02:31:59,546 MIDDLE. 3803 02:31:59,546 --> 02:32:04,317 SO, THAT'S WHAT WE CAN SAY ABOUT 3804 02:32:04,317 --> 02:32:07,220 THE PRECEDENT THAT'S THERE NOW. 3805 02:32:07,220 --> 02:32:09,956 RIGHT NOW, YEAH, THE PEOPLE CAN 3806 02:32:09,956 --> 02:32:11,858 HAVE THE MOST INFLUENCE NOW 3807 02:32:11,858 --> 02:32:15,195 WOULD PROBABLY BE THE SENATE. 3808 02:32:15,195 --> 02:32:25,471 >> THANK YOU. 3809 02:32:26,606 --> 02:32:29,209 >> I HAVE A QUICK POINT. 3810 02:32:29,209 --> 02:32:31,678 IT CUTS INTO WHAT EVERYBODY ELSE 3811 02:32:31,678 --> 02:32:32,612 IS SAYING, ESPECIALLY FRANCES. 3812 02:32:32,612 --> 02:32:35,782 WHEN HE SHOWED THE POLL OF HOW 3813 02:32:35,782 --> 02:32:37,317 PEOPLE FEEL AND THEIR CONFIDENCE 3814 02:32:37,317 --> 02:32:41,120 IN SCIENCE AND THE CRISIS OF 3815 02:32:41,120 --> 02:32:42,155 REPRODUCIBILITY, THE LAST TIME 3816 02:32:42,155 --> 02:32:45,692 THAT WAS DONE WAS IN OCTOBER OF 3817 02:32:45,692 --> 02:32:45,892 2024. 3818 02:32:45,892 --> 02:32:47,126 SO IT MAY MAKE SENSE TO THINK 3819 02:32:47,126 --> 02:32:49,562 ABOUT WHAT WE THINK THE PUBLIC'S 3820 02:32:49,562 --> 02:32:52,966 OPINION WILL BE, THE NEXT TIME 3821 02:32:52,966 --> 02:32:56,135 IT'S POLLED, IS IT GOING TO GET 3822 02:32:56,135 --> 02:32:58,571 SIGNIFICANTLY WORSE, PEOPLE WILL 3823 02:32:58,571 --> 02:33:00,506 REALIZE SCIENCE HAS VALUE, WILL 3824 02:33:00,506 --> 02:33:03,209 IT GET BETTER? 3825 02:33:03,209 --> 02:33:06,512 AGAIN, THIS IS TAXPAYER DOLLARS, 3826 02:33:06,512 --> 02:33:08,181 WE HAVE TO ADDRESS WHAT 3827 02:33:08,181 --> 02:33:09,249 TAXPAYERS THINK OF OUR VALUE. 3828 02:33:09,249 --> 02:33:10,416 I DON'T KNOW IF THERE'S 3829 02:33:10,416 --> 02:33:12,185 SOMETHING GOING BACK TO FRANCES' 3830 02:33:12,185 --> 02:33:16,456 POINT OF SOME SORT OF, YOU KNOW, 3831 02:33:16,456 --> 02:33:17,257 KIND OF CONCERTED EFFORT TO -- 3832 02:33:17,257 --> 02:33:18,625 PEOPLE ARE GOING TO BELIEVE WHAT 3833 02:33:18,625 --> 02:33:21,861 THEY ARE GOING TO BELIEVE BUT TO 3834 02:33:21,861 --> 02:33:22,495 BASICALLY SHOW THAT THESE 3835 02:33:22,495 --> 02:33:26,766 SCANDALS OF THINGS ARE ACTUALLY 3836 02:33:26,766 --> 02:33:29,702 QUITE RARE AND HOW CAN WE, YOU 3837 02:33:29,702 --> 02:33:31,571 KNOW, AS A SCIENTIFIC SOCIETY 3838 02:33:31,571 --> 02:33:33,373 AND GROUP KIND OF GET AHEAD OF 3839 02:33:33,373 --> 02:33:39,512 THIS, IF ALL OF A SUDDEN NOW IN 3840 02:33:39,512 --> 02:33:40,880 JUNE OF 2025 OR LATER DATA SHOWS 3841 02:33:40,880 --> 02:33:43,016 THE PUBLIC HAS LOST EVEN MORE 3842 02:33:43,016 --> 02:33:43,483 SUPPORT OF SCIENCE? 3843 02:33:43,483 --> 02:33:49,322 I DON'T KNOW IF I'M MAKING ANY 3844 02:33:49,322 --> 02:33:51,624 SENSE, SORRY. 3845 02:33:51,624 --> 02:33:53,559 >> YEAH, SO I'D JUST SAY THAT, 3846 02:33:53,559 --> 02:33:54,761 YOU KNOW, I'VE BEEN WORRIED 3847 02:33:54,761 --> 02:34:00,066 ABOUT THIS FOR A WHILE. 3848 02:34:00,066 --> 02:34:02,535 IN THE PREVIOUS -- WHEN TABAK 3849 02:34:02,535 --> 02:34:06,506 WAS THE ACTING, WHAT I WAS 3850 02:34:06,506 --> 02:34:07,640 PROPOSING THAT NIH DO IS TO 3851 02:34:07,640 --> 02:34:12,145 DEVELOP WITH A GROUP OF PEOPLE 3852 02:34:12,145 --> 02:34:15,715 THE UNIVERSITIES WE FUND, 3853 02:34:15,715 --> 02:34:17,283 DISEASE ORGANIZATIONS, TO 3854 02:34:17,283 --> 02:34:18,351 ORGANIZE THE MESSAGING BECAUSE 3855 02:34:18,351 --> 02:34:20,753 RIGHT NOW THE MESSAGING AROUND 3856 02:34:20,753 --> 02:34:25,391 SCIENCE IS VERY KIND OF HIT OR 3857 02:34:25,391 --> 02:34:28,895 MISS, HERE OR THERE, AND IT 3858 02:34:28,895 --> 02:34:30,997 DOESN'T NECESSARILY SPEAK TO THE 3859 02:34:30,997 --> 02:34:34,000 PEOPLE WHO DON'T ALREADY BUY 3860 02:34:34,000 --> 02:34:34,534 INTO IT. 3861 02:34:34,534 --> 02:34:36,069 SO I THINK -- I ALWAYS THOUGHT 3862 02:34:36,069 --> 02:34:38,304 THAT -- AND IF THE GOVERNMENT 3863 02:34:38,304 --> 02:34:39,639 DOES THE MESSAGING, THAT'S GOING 3864 02:34:39,639 --> 02:34:41,808 TO NOT GO THAT FAR. 3865 02:34:41,808 --> 02:34:45,478 BUT I THINK THAT FOR INSTANCE WE 3866 02:34:45,478 --> 02:34:47,480 FUND PEOPLE IN EVERY, YOU KNOW, 3867 02:34:47,480 --> 02:34:49,082 UNIVERSITY IN THE COUNTRY, AND 3868 02:34:49,082 --> 02:34:50,450 THOSE ARE THE UNIVERSITIES AT 3869 02:34:50,450 --> 02:34:53,152 THE LOCAL LEVEL THAT ARE MORE 3870 02:34:53,152 --> 02:34:54,754 LIKELY TO BE TRUSTED THAN THE 3871 02:34:54,754 --> 02:34:55,421 GOVERNMENT IN D.C. 3872 02:34:55,421 --> 02:34:58,458 SO I THINK WE COULD DO A LOT 3873 02:34:58,458 --> 02:35:03,062 BETTER AS A COMMUNITY IF WE 3874 02:35:03,062 --> 02:35:05,832 ORGANIZE OURSELVES AS THE 3875 02:35:05,832 --> 02:35:07,967 TENTACLES TO A -- TENTACLES ARE 3876 02:35:07,967 --> 02:35:11,504 ALL OUT INTO THE COMMUNITIES 3877 02:35:11,504 --> 02:35:13,973 THAT MATTER, AND WITH SOMEHOW 3878 02:35:13,973 --> 02:35:17,243 COORDINATED MESSAGING GOING OUT. 3879 02:35:17,243 --> 02:35:17,910 THE UNIVERSITIES COULD STILL, 3880 02:35:17,910 --> 02:35:20,747 YOU KNOW, PAT THEMSELVES ON THE 3881 02:35:20,747 --> 02:35:22,482 BACK FOR WHAT THEIR 3882 02:35:22,482 --> 02:35:23,783 INVESTIGATORS HAVE DONE, BUT 3883 02:35:23,783 --> 02:35:25,985 STORY WOULD SHOW US ALL THE TIME 3884 02:35:25,985 --> 02:35:27,120 THAT -- AND YOU SEE IT, YOU 3885 02:35:27,120 --> 02:35:31,457 KNOW, ALL THE TIME IN THE PAPER 3886 02:35:31,457 --> 02:35:32,392 BIG WRITE-UP, NEVER MENTIONING 3887 02:35:32,392 --> 02:35:36,229 THAT NIH FUNDED IT. 3888 02:35:36,229 --> 02:35:38,164 SO WE HAVEN'T -- NO ONE'S 3889 02:35:38,164 --> 02:35:39,365 ACTUALLY TAKEN THIS BULL BY THE 3890 02:35:39,365 --> 02:35:41,834 HORNS BUT THERE'S A LOT THAT 3891 02:35:41,834 --> 02:35:44,470 COULD BE DONE, BUT IT REQUIRES 3892 02:35:44,470 --> 02:35:44,937 SOME ORGANIZATION. 3893 02:35:44,937 --> 02:35:45,972 >> I THINK THAT'S, YEAH, THE 3894 02:35:45,972 --> 02:35:48,241 ORGANIZATION IS WHAT WE NEED, 3895 02:35:48,241 --> 02:35:50,476 WHO WE'RE TARGETING. 3896 02:35:50,476 --> 02:35:52,979 YOU KNOW, SO SOME AMAZING STUDY 3897 02:35:52,979 --> 02:35:54,580 IN NEURON OR WHATEVER, THAT'S 3898 02:35:54,580 --> 02:35:58,684 NOT GOING TO IMPRESS THE 3899 02:35:58,684 --> 02:35:58,951 COMMUNITY. 3900 02:35:58,951 --> 02:36:02,755 OVER THE PAST 150 YEARS OUR 3901 02:36:02,755 --> 02:36:05,291 LIFESPAN HAS GONE FROM AVERAGE 3902 02:36:05,291 --> 02:36:07,460 AGE OF 37 TO 81. 3903 02:36:07,460 --> 02:36:10,763 GIVEN THOSE SORT OF -- THAT KIND 3904 02:36:10,763 --> 02:36:13,466 OF INFORMATION MAYBE MORE KIND 3905 02:36:13,466 --> 02:36:14,767 OF REACHING THE PEOPLE THAT MAY 3906 02:36:14,767 --> 02:36:17,737 BE THE ONES THAT THINK SCIENCE 3907 02:36:17,737 --> 02:36:18,805 ISN'T DOING ANYTHING. 3908 02:36:18,805 --> 02:36:20,740 I THINK IT WOULD REQUIRE SOME 3909 02:36:20,740 --> 02:36:22,775 ORGANIZATION, AND I THINK IT 3910 02:36:22,775 --> 02:36:23,709 WOULD REQUIRE UNIVERSITIES, BUT 3911 02:36:23,709 --> 02:36:24,744 I THINK IT WOULD ALSO REQUIRE 3912 02:36:24,744 --> 02:36:27,380 LIKE MAYBE SOME OF OUR JUNIOR 3913 02:36:27,380 --> 02:36:28,948 FOLKS OR STUDENTS OR SOME PEOPLE 3914 02:36:28,948 --> 02:36:30,750 IN THE COMMUNITY REALLY KIND OF 3915 02:36:30,750 --> 02:36:31,851 HAMMERING THIS MESSAGE HOME. 3916 02:36:31,851 --> 02:36:36,189 I'M NOT SURE HOW TO DO IT. 3917 02:36:36,189 --> 02:36:38,825 >> YEAH, THAT'S RIGHT. 3918 02:36:38,825 --> 02:36:41,394 YEAH, SO THE OTHER -- WHAT YOU 3919 02:36:41,394 --> 02:36:43,830 HINTED AT THERE'S A WHOLE NEW 3920 02:36:43,830 --> 02:36:44,397 WAY PEOPLE ARE COMMUNICATING 3921 02:36:44,397 --> 02:36:46,165 NOW, AROUND I DON'T KNOW ABOUT 3922 02:36:46,165 --> 02:36:51,070 YOU GUYS, BUT WE'RE NOT IN THAT 3923 02:36:51,070 --> 02:36:52,705 SPACE. 3924 02:36:52,705 --> 02:36:57,610 AND SO THAT'S A LOST PIECE OF 3925 02:36:57,610 --> 02:36:59,178 AMMUNITION. 3926 02:36:59,178 --> 02:37:00,947 >> I GUESS IT'S JUST SOMETHING 3927 02:37:00,947 --> 02:37:02,448 TO THINK ABOUT, LIKE ABOUT HOW 3928 02:37:02,448 --> 02:37:04,817 TO STRUCTURE THAT OR HOW DO WE 3929 02:37:04,817 --> 02:37:05,351 EACH INDIVIDUALLY TRY AND 3930 02:37:05,351 --> 02:37:08,054 CONTRIBUTE AS MUCH AS WE CAN TO 3931 02:37:08,054 --> 02:37:09,989 KIND OF SHOWING, YES, THIS IS 3932 02:37:09,989 --> 02:37:11,457 WHAT SCIENCE HAS DONE, AND THIS 3933 02:37:11,457 --> 02:37:13,459 IS WHAT THIS STUDY HAS DONE AND 3934 02:37:13,459 --> 02:37:15,895 THIS IS WHAT THIS DRUG HAS DONE 3935 02:37:15,895 --> 02:37:17,663 AND THIS IS WHAT, YOU KNOW, CAR 3936 02:37:17,663 --> 02:37:19,765 T THERAPY HAS DONE. 3937 02:37:19,765 --> 02:37:21,234 YOU KNOW, PATIENT GROUPS ARE 3938 02:37:21,234 --> 02:37:22,768 PROBABLY THE BEST WAY TO HAVE 3939 02:37:22,768 --> 02:37:24,837 THE PATIENTS THAT ARE AFFECTED 3940 02:37:24,837 --> 02:37:29,041 BY THESE DISEASES AND HAVE 3941 02:37:29,041 --> 02:37:30,743 GOTTEN TREATMENTS OR WHATEVER, 3942 02:37:30,743 --> 02:37:33,713 MAYBE, BUT I THINK IT WOULD 3943 02:37:33,713 --> 02:37:36,048 REQUIRE SOME SERIOUS 3944 02:37:36,048 --> 02:37:36,382 ORGANIZATION. 3945 02:37:36,382 --> 02:37:42,989 ANYWAY ... 3946 02:37:42,989 --> 02:37:43,823 >> ALL RIGHT. 3947 02:37:43,823 --> 02:37:46,692 I THINK WE TAKE A BREAK NOW. 3948 02:37:46,692 --> 02:37:50,696 WHAT TIME DO WE COME BACK? 3949 02:37:50,696 --> 02:37:53,633 COME BACK AT 1:30 EASTERN 3950 02:37:53,633 --> 02:37:54,267 STANDARD TIME. 3951 02:37:54,267 --> 02:37:56,202 AND, YEAH, WE HAVE SOME REALLY 3952 02:37:56,202 --> 02:38:06,646 GREAT THINGS TO TALK TERMS 3953 02:38:27,200 --> 02:38:31,470 OF GENETICS, AND THE DARK MATTER 3954 02:38:31,470 --> 02:38:36,008 IS WHAT ARE THE OTHER DRIVERS 3955 02:38:36,008 --> 02:38:38,177 AND THAT CERTAINLY HAS BEEN 3956 02:38:38,177 --> 02:38:43,115 DIFFICULT TO GET AT. 3957 02:38:43,115 --> 02:38:47,753 WE'VE REALLY ENJOYED THE HELP OF 3958 02:38:47,753 --> 02:38:51,090 THE NIEHS, DR. RICK WOYCHIK, THE 3959 02:38:51,090 --> 02:38:52,225 DIRECTOR OF NIEHS IS GOING TO 3960 02:38:52,225 --> 02:38:53,893 JOIN US. 3961 02:38:53,893 --> 02:38:55,962 A COUPLE YEARS AGO DAVID JETTE 3962 02:38:55,962 --> 02:38:58,064 AND SHARDELL SPRIGGS HAD THE 3963 02:38:58,064 --> 02:39:00,900 IDEA OF SPINNING OFF AN OFFICE 3964 02:39:00,900 --> 02:39:02,635 OF EXPOSOME RESEARCH, TO KIND OF 3965 02:39:02,635 --> 02:39:04,837 GET INTO THIS SPACE THAT WE 3966 02:39:04,837 --> 02:39:07,106 THINK IS SO IMPORTANT. 3967 02:39:07,106 --> 02:39:11,978 AND SO WE'RE GOING TO HEAR FROM 3968 02:39:11,978 --> 02:39:13,646 THEM TODAY ABOUT HOW THEY THINK 3969 02:39:13,646 --> 02:39:16,349 ABOUT MOVING OFF THEIR STRATEGIC 3970 02:39:16,349 --> 02:39:20,152 PLAN AND COMMENTARY AND SOME 3971 02:39:20,152 --> 02:39:20,953 INPUT FROM DR. WOYCHIK. 3972 02:39:20,953 --> 02:39:26,425 LET ME HAND IT OVER TO DAVID, IS 3973 02:39:26,425 --> 02:39:32,531 THAT RIGHT? 3974 02:39:32,531 --> 02:39:35,134 WHO IS GOING TO GO FIRST? 3975 02:39:35,134 --> 02:39:35,334 RICK. 3976 02:39:35,334 --> 02:39:37,370 >> I THOUGHT, WALTER, I WAS 3977 02:39:37,370 --> 02:39:37,737 GOING FIRST. 3978 02:39:37,737 --> 02:39:39,372 >> YES, YOU ARE GOING FIRST. 3979 02:39:39,372 --> 02:39:40,406 YOU ARE CORRECT. 3980 02:39:40,406 --> 02:39:41,007 >> OKAY. 3981 02:39:41,007 --> 02:39:41,274 VERY GOOD. 3982 02:39:41,274 --> 02:39:43,142 EVERYONE CAN HEAR ME OKAY? 3983 02:39:43,142 --> 02:39:44,176 >> I STAND CORRECTED. 3984 02:39:44,176 --> 02:39:45,845 RICK, VERY GOOD. 3985 02:39:45,845 --> 02:39:47,980 >> TERRIFIC. 3986 02:39:47,980 --> 02:39:49,315 WELL, DELIGHTED TO BE HERE, TO 3987 02:39:49,315 --> 02:39:50,750 WALTER AND DAVID AND OTHERS, 3988 02:39:50,750 --> 02:39:53,019 THANK YOU FOR THE INVITATION. 3989 02:39:53,019 --> 02:39:54,720 I UNDERSTAND SOMEBODY HAS MY 3990 02:39:54,720 --> 02:39:56,289 SLIDES, AND CAN YOU SHARE MY 3991 02:39:56,289 --> 02:39:56,622 SLIDES. 3992 02:39:56,622 --> 02:39:57,823 THERE WE ARE. 3993 02:39:57,823 --> 02:39:58,524 GREAT. 3994 02:39:58,524 --> 02:39:59,125 OKAY. 3995 02:39:59,125 --> 02:40:01,594 I'M GOING TO TAKE A FEW MINUTES 3996 02:40:01,594 --> 02:40:02,395 TO OPEN THE DISCUSSION AND TURN 3997 02:40:02,395 --> 02:40:09,335 IT OVER TO DAVID AND HIS 3998 02:40:09,335 --> 02:40:11,704 COLLEAGUES TO TALK ABOUT THE 3999 02:40:11,704 --> 02:40:12,838 EXPOSOME. 4000 02:40:12,838 --> 02:40:14,707 I'M CURRENTLY IN WASHINGTON AT 4001 02:40:14,707 --> 02:40:16,075 THE EXPOSOME MOONSHOT AGAIN WITH 4002 02:40:16,075 --> 02:40:18,244 DAVID AND OTHERS. 4003 02:40:18,244 --> 02:40:22,148 THE IDEA IS HOW TO -- TO REALLY 4004 02:40:22,148 --> 02:40:24,283 GET THE BIOMEDICAL RESEARCH 4005 02:40:24,283 --> 02:40:25,685 COMMUNITY EMBRACING THE CONCEPT 4006 02:40:25,685 --> 02:40:27,987 OF THE EXPOSOME. 4007 02:40:27,987 --> 02:40:29,322 LET ME TAKE YOU THROUGH AND 4008 02:40:29,322 --> 02:40:34,226 PROVIDE INTRODUCTORY REMARKS. 4009 02:40:34,226 --> 02:40:36,228 NEXT SLIDE PLEASE. 4010 02:40:36,228 --> 02:40:36,429 OKAY. 4011 02:40:36,429 --> 02:40:37,430 NEXT SLIDE. 4012 02:40:37,430 --> 02:40:39,198 HERE WE ARE. 4013 02:40:39,198 --> 02:40:41,400 AND SO, WELL, WALTER JUST GAVE 4014 02:40:41,400 --> 02:40:43,736 YOU AN INTRODUCTION HERE. 4015 02:40:43,736 --> 02:40:49,342 I'M A GENETICIST BY TRAINING, 4016 02:40:49,342 --> 02:40:51,410 RECENTLY I HAVE MY FOOT IN 4017 02:40:51,410 --> 02:40:52,478 GENETICS AND ENVIRONMENTAL 4018 02:40:52,478 --> 02:40:54,280 HEALTH SCIENCES CAMPS. 4019 02:40:54,280 --> 02:40:56,982 I DON'T THINK THERE'S ANY 4020 02:40:56,982 --> 02:40:57,683 QUESTION BETWEEN PUBLICATIONS 4021 02:40:57,683 --> 02:40:59,485 AND THE FINISHING OF THE HUMAN 4022 02:40:59,485 --> 02:41:04,223 GENOME PROJECT THAT WE CAN NOW 4023 02:41:04,223 --> 02:41:05,758 DO EXPERIMENTS IN GENETICS, 4024 02:41:05,758 --> 02:41:08,227 HUMAN GENETICS, THAT WE COULDN'T 4025 02:41:08,227 --> 02:41:10,496 EVEN IMAGINE DOING JUST A FEW -- 4026 02:41:10,496 --> 02:41:12,131 A COUPLE DECADES AGO. 4027 02:41:12,131 --> 02:41:14,333 NEXT SLIDE. 4028 02:41:14,333 --> 02:41:16,135 JUST EXAMPLES OF THIS WOULD BE 4029 02:41:16,135 --> 02:41:19,572 IT'S TRANSFORMED OUR ABILITY TO 4030 02:41:19,572 --> 02:41:22,007 FIND THOSE MENDELIAN TRAITS, 4031 02:41:22,007 --> 02:41:23,042 SINGLE GENE ALLELIC VARIANTS 4032 02:41:23,042 --> 02:41:25,211 LURKING IN THE GENOME BACKGROUND 4033 02:41:25,211 --> 02:41:26,512 THAT WE CAN DECIPHER. 4034 02:41:26,512 --> 02:41:28,914 WE'VE BEEN FINDING THOSE WITH 4035 02:41:28,914 --> 02:41:29,782 GREATER FREQUENCY AND EASE, OF 4036 02:41:29,782 --> 02:41:32,885 COURSE THE ABILITY TO GO IN AND 4037 02:41:32,885 --> 02:41:36,956 STUDY COMPLEX TRAITS, DO THE 4038 02:41:36,956 --> 02:41:39,458 GWAS EXPERIMENTS. 4039 02:41:39,458 --> 02:41:40,092 ENABLED BY HAVING ACCESS TO 4040 02:41:40,092 --> 02:41:41,293 WHOLE GENOME SEQUENCES. 4041 02:41:41,293 --> 02:41:41,660 NEXT SLIDE. 4042 02:41:41,660 --> 02:41:43,162 IF YOU LOOK SPECIFICALLY AT THE 4043 02:41:43,162 --> 02:41:46,899 ABILITY TO LOOK AT, SAY, THE 4044 02:41:46,899 --> 02:41:47,400 TRAITS ASSOCIATED WITH 4045 02:41:47,400 --> 02:41:49,068 PARKINSON'S DISEASE AND THERE 4046 02:41:49,068 --> 02:41:50,636 ARE LOTS OF DIFFERENT LOCI 4047 02:41:50,636 --> 02:41:51,604 ACROSS THE GENOME THAT ALL 4048 02:41:51,604 --> 02:41:53,506 CONTRIBUTE TO THIS DISEASE. 4049 02:41:53,506 --> 02:41:54,473 OF COURSE, THESE ARE COMPLEX 4050 02:41:54,473 --> 02:41:55,975 TRAITS, THEY ALL WORK IN SYNERGY 4051 02:41:55,975 --> 02:41:58,611 WITH EACH OTHER. 4052 02:41:58,611 --> 02:41:59,945 THE GENOME PROJECT ABSOLUTELY 4053 02:41:59,945 --> 02:42:00,913 REVOLUTIONIZED OUR ABILITY TO DO 4054 02:42:00,913 --> 02:42:05,151 THESE TYPES OF EXPERIMENTS. 4055 02:42:05,151 --> 02:42:05,785 NEXT SLIDE. 4056 02:42:05,785 --> 02:42:10,489 THE WAY I LOOK AT THIS IS THAT 4057 02:42:10,489 --> 02:42:11,957 THE GENETICS AND GENOMICS TO 4058 02:42:11,957 --> 02:42:13,659 HELP MOVE THE BALL DOWN THE -- 4059 02:42:13,659 --> 02:42:17,630 MOFFITT DOWN TO MAYBE THE 4060 02:42:17,630 --> 02:42:18,364 50-YARD LINE, AND SO WE HAVEN'T 4061 02:42:18,364 --> 02:42:20,032 BROUGHT IT TO THE FINISH LINE 4062 02:42:20,032 --> 02:42:20,199 YET. 4063 02:42:20,199 --> 02:42:21,600 WE'RE NOT SCORING A TOUCHDOWN. 4064 02:42:21,600 --> 02:42:24,003 PART OF THE REASON, WE HAVE THE 4065 02:42:24,003 --> 02:42:25,504 DARK MATTER, AS WALTER WAS 4066 02:42:25,504 --> 02:42:26,872 REFERRING TO THIS, AT THE 4067 02:42:26,872 --> 02:42:29,341 BEGINNING OF THE PRESENTATION 4068 02:42:29,341 --> 02:42:29,542 HERE. 4069 02:42:29,542 --> 02:42:30,843 AND IT'S BECAUSE THERE ARE 4070 02:42:30,843 --> 02:42:35,281 THINGS WE KNOW IN THE 4071 02:42:35,281 --> 02:42:35,581 ENVIRONMENT. 4072 02:42:35,581 --> 02:42:38,384 LEAD, ARSENIC, PFAS, FLAME 4073 02:42:38,384 --> 02:42:38,918 RETARDANTS, ESPECIALLY 4074 02:42:38,918 --> 02:42:42,021 PESTICIDES IN CONNECTION WITH 4075 02:42:42,021 --> 02:42:42,455 PARKINSON'S DISEASE. 4076 02:42:42,455 --> 02:42:46,158 THESE ARE KNOWN AGENTS WITH THE 4077 02:42:46,158 --> 02:42:47,593 ASSOCIATION OF DEVELOPING 4078 02:42:47,593 --> 02:42:48,594 NEUROLOGIC DISORDERS OF THE WE 4079 02:42:48,594 --> 02:42:50,229 CAN'T LOOK JUST AT GENETICS. 4080 02:42:50,229 --> 02:42:52,198 WE HAVE TO LOOK AT THE 4081 02:42:52,198 --> 02:42:53,432 ENVIRONMENTAL FACTORS WHICH I 4082 02:42:53,432 --> 02:42:55,134 SUSPECT IN MOST CASES ARE REALLY 4083 02:42:55,134 --> 02:43:01,440 WORKING IN CONCERT WITH OUR 4084 02:43:01,440 --> 02:43:05,311 GENETIC BACKGROUNDS TO 4085 02:43:05,311 --> 02:43:06,245 ULTIMATELY CAUSE THESE 4086 02:43:06,245 --> 02:43:07,046 NEUROLOGICAL EFFECTS. 4087 02:43:07,046 --> 02:43:07,346 NEXT SLIDE. 4088 02:43:07,346 --> 02:43:13,085 IF YOU JUST LOOK AT AIR 4089 02:43:13,085 --> 02:43:15,387 POLLUTION, THERE'S BEHAVIORAL 4090 02:43:15,387 --> 02:43:16,288 PROBLEMS, DISEASES, AUTISM, 4091 02:43:16,288 --> 02:43:18,457 ASSOCIATION STUDIES DONE JUST 4092 02:43:18,457 --> 02:43:21,060 WITH AIR POLLUTION THAT REALLY 4093 02:43:21,060 --> 02:43:24,330 POINT TO THE IMPORTANCE OF 4094 02:43:24,330 --> 02:43:27,466 LOOKING AT ENVIRONMENTAL 4095 02:43:27,466 --> 02:43:30,436 EXPOSURES, STUDYING ETIOLOGY OF 4096 02:43:30,436 --> 02:43:30,903 NEUROLOGICAL DISEASES. 4097 02:43:30,903 --> 02:43:31,904 NEXT SLIDE. 4098 02:43:31,904 --> 02:43:34,807 INTRODUCING THE TOPIC OF TODAY'S 4099 02:43:34,807 --> 02:43:38,210 DISCUSSION, THE EXPOSOME. 4100 02:43:38,210 --> 02:43:40,813 BACK IN 2005 WHEN THE 4101 02:43:40,813 --> 02:43:45,818 ENVIRONMENTAL HEALTH SCIENCES 4102 02:43:45,818 --> 02:43:47,853 COMMUNITY CHOSE CHRIS WILD 4103 02:43:47,853 --> 02:43:48,187 SPECIFICALLY. 4104 02:43:48,187 --> 02:43:49,054 HIS PROPOSAL IF YOU WANT TO 4105 02:43:49,054 --> 02:43:51,156 UNDERSTAND THE IMPACT OF THE 4106 02:43:51,156 --> 02:43:53,359 ENVIRONMENT WE HAVE TO GET 4107 02:43:53,359 --> 02:43:55,461 AROUND STUDYING ONE EXPOSURE AT 4108 02:43:55,461 --> 02:43:56,028 A TIME. 4109 02:43:56,028 --> 02:44:00,766 MUCH LIKE THE GENOME MUCH WAS -- 4110 02:44:00,766 --> 02:44:01,767 PROJECT WAS GETTING AROUND ONE 4111 02:44:01,767 --> 02:44:05,004 GENE AT A TIME, THE EXPOSOME 4112 02:44:05,004 --> 02:44:06,539 FRAMEWORK IS STUDYING THE 4113 02:44:06,539 --> 02:44:07,439 TOTALITY OF EXPOSURES I'VE THE 4114 02:44:07,439 --> 02:44:08,474 LIFE COURSE. 4115 02:44:08,474 --> 02:44:12,378 THIS MEANS THAT WE NEED A NEW 4116 02:44:12,378 --> 02:44:15,014 RESEARCH FRAMEWORK TO STUDY NOT 4117 02:44:15,014 --> 02:44:16,215 JUST ONE CHEMICAL EXPOSURE IN 4118 02:44:16,215 --> 02:44:20,619 THE BLUE BOX AT THE BOTTOM, NOT 4119 02:44:20,619 --> 02:44:26,392 JUST ONE PESTICIDE OR ONE PCB OR 4120 02:44:26,392 --> 02:44:28,160 PFAS, WE NEED TO DEVELOP A 4121 02:44:28,160 --> 02:44:29,295 STRATEGY LOOKING AT ALL THESE 4122 02:44:29,295 --> 02:44:30,629 DIFFERENT THINGS. 4123 02:44:30,629 --> 02:44:31,564 BUT MOST IMPORTANTLY, IT'S 4124 02:44:31,564 --> 02:44:33,999 SOMETHING I REALLY WANT TO 4125 02:44:33,999 --> 02:44:35,601 EMPHASIZE, THIS WAS A BIG PART 4126 02:44:35,601 --> 02:44:39,772 OF THE DISCUSSION AT THE 4127 02:44:39,772 --> 02:44:40,673 EXPOSOME MOONSHOT MEETINGS THAT 4128 02:44:40,673 --> 02:44:42,341 HAPPENED UP TO THIS POINT OVER 4129 02:44:42,341 --> 02:44:43,576 THE LAST COUPLE DAYS. 4130 02:44:43,576 --> 02:44:45,978 IT CAN'T BE JUST ABOUT THE 4131 02:44:45,978 --> 02:44:47,012 PHYSICAL CHEMICAL EXPOSURES. 4132 02:44:47,012 --> 02:44:49,582 WE HAVE TO BE INTEGRATED THE 4133 02:44:49,582 --> 02:44:52,217 SOCIAL, THE LIFESTYLE, THE 4134 02:44:52,217 --> 02:44:53,719 ECOSYSTEM VARIABLES, THE SOCIAL 4135 02:44:53,719 --> 02:44:56,021 DETERMINANTS OF HEALTH THAT CAN 4136 02:44:56,021 --> 02:44:59,725 BE WORKING IN SYNERGY WITH SOME 4137 02:44:59,725 --> 02:45:00,793 OF THE PHYSICAL CHEMICAL 4138 02:45:00,793 --> 02:45:03,629 EXPOSURES THAT CAN ULTIMATE LID 4139 02:45:03,629 --> 02:45:05,097 TRIGGER NEUROLOGICAL DISEASES. 4140 02:45:05,097 --> 02:45:06,098 FURTHERMORE WHAT WE'RE FINDING 4141 02:45:06,098 --> 02:45:08,300 IS THAT THERE MAY BE CERTAIN 4142 02:45:08,300 --> 02:45:11,003 LIFESTYLE VARIABLES. 4143 02:45:11,003 --> 02:45:12,671 FOR EXAMPLE, OLD-FASHIONED 4144 02:45:12,671 --> 02:45:13,706 PHYSICAL ACTIVITY, GETTING ON 4145 02:45:13,706 --> 02:45:16,208 THE TREADMILL WITH SOME 4146 02:45:16,208 --> 02:45:18,444 REGULARITY, OR GETTING QUALITY 4147 02:45:18,444 --> 02:45:21,547 SLEEP, OR GOOD QUALITY DIETS. 4148 02:45:21,547 --> 02:45:22,181 WE HAVE SOME INVESTIGATORS THAT 4149 02:45:22,181 --> 02:45:25,117 ARE FUNDED AT THE UNIVERSITY OF 4150 02:45:25,117 --> 02:45:27,853 KENTUCKY THAT DEMONSTRATED THAT 4151 02:45:27,853 --> 02:45:28,821 THERE'S POLYPHENOLS IN 4152 02:45:28,821 --> 02:45:29,688 BLACKBERRIES AND BLUEBERRIES 4153 02:45:29,688 --> 02:45:31,323 THAT MITIGATE SOME NEGATIVE 4154 02:45:31,323 --> 02:45:33,626 EFFECTS OF CHEMICAL EXPOSURES AS 4155 02:45:33,626 --> 02:45:35,828 RELATES TO THE DEVELOPMENT OF 4156 02:45:35,828 --> 02:45:36,629 TYPE 2 DIABETES. 4157 02:45:36,629 --> 02:45:39,832 WE NEED TO DEVELOP THIS EXPOSOME 4158 02:45:39,832 --> 02:45:41,133 FRAMEWORK, WHAT DATA DO WE 4159 02:45:41,133 --> 02:45:42,668 COLLECT, WHEN DO WE COLLECT IT? 4160 02:45:42,668 --> 02:45:44,436 HOW DO WE BRING ALL OF THESE 4161 02:45:44,436 --> 02:45:47,006 DIFFERENT THINGS TOGETHER IN A 4162 02:45:47,006 --> 02:45:48,741 MEANINGFUL WAY, AND TO DO THIS 4163 02:45:48,741 --> 02:45:50,309 OVER THE LIFE COURSE BECAUSE IT 4164 02:45:50,309 --> 02:45:52,511 CAN'T JUST BE IMMEDIATE PAST 4165 02:45:52,511 --> 02:45:53,879 EXPOSURE THAT WE STUDY, BECAUSE 4166 02:45:53,879 --> 02:45:55,381 AS WE'RE DISCOVERING THAT MANY 4167 02:45:55,381 --> 02:45:58,183 OF THOSE EXPOSURES THAT HAPPENED 4168 02:45:58,183 --> 02:46:00,519 ACTUALLY DURING PREGNANCY, 4169 02:46:00,519 --> 02:46:02,688 DURING DEVELOPMENT, OR EVEN 4170 02:46:02,688 --> 02:46:04,223 POSSIBLY BEFORE THE HUSBAND AND 4171 02:46:04,223 --> 02:46:05,958 WIFE MEET EACH OTHER, BEFORE 4172 02:46:05,958 --> 02:46:06,625 CONCEPTION. 4173 02:46:06,625 --> 02:46:09,495 THERE CAN BE EXPOSURES THAT CAN 4174 02:46:09,495 --> 02:46:10,562 BE IMPACTING HOW YOUR GENES WORK 4175 02:46:10,562 --> 02:46:13,866 LATER IN LIFE AND MANY OF THOSE 4176 02:46:13,866 --> 02:46:14,767 ARE THROUGH EPIGENETIC METHODS. 4177 02:46:14,767 --> 02:46:16,902 WE'VE GOT TO COME UP WITH THE 4178 02:46:16,902 --> 02:46:23,609 NEW EXPOSOME FRAMEWORK. 4179 02:46:23,609 --> 02:46:24,109 NEXT SLIDE. 4180 02:46:24,109 --> 02:46:26,211 THAT'S WHAT THE MEETING IN 4181 02:46:26,211 --> 02:46:26,979 WASHINGTON, EXPOSOME MOONSHOT, 4182 02:46:26,979 --> 02:46:27,579 IS CURRENTLY DOING. 4183 02:46:27,579 --> 02:46:29,081 STARTING WITH A BOLD VISION LIKE 4184 02:46:29,081 --> 02:46:32,217 THE GENOME PROJECT STARTED WITH 4185 02:46:32,217 --> 02:46:34,453 A BOLD VISION AROUND SEQUENCING 4186 02:46:34,453 --> 02:46:36,255 THE IMPACT OF SEQUENCING THE 4187 02:46:36,255 --> 02:46:37,523 ENTIRE GENOME, HOW THAT COULD 4188 02:46:37,523 --> 02:46:40,759 FOLKSILY TRANSFORM THE WAY WE DO 4189 02:46:40,759 --> 02:46:41,994 GENETICS AND GENOMICS RESEARCH, 4190 02:46:41,994 --> 02:46:42,795 AND IT HAS. 4191 02:46:42,795 --> 02:46:45,230 WE NEED A BOLD VISION AROUND THE 4192 02:46:45,230 --> 02:46:46,932 EXPOSOME, CALLING IT THE HUMAN 4193 02:46:46,932 --> 02:46:48,200 EXPOSOME PROJECT. 4194 02:46:48,200 --> 02:46:49,268 WE NEED TO HAVE A DEFINITION OF 4195 02:46:49,268 --> 02:46:51,170 WHAT IS THE EXPOSOME. 4196 02:46:51,170 --> 02:46:52,337 WE NEED TO THINK ABOUT THE 4197 02:46:52,337 --> 02:46:54,173 TECHNOLOGY THAT WE'RE GOING TO 4198 02:46:54,173 --> 02:46:57,009 NEED TO CAPTURE THE EXPOSOME. 4199 02:46:57,009 --> 02:47:00,646 JUST LIKE WITH THE GENOME 4200 02:47:00,646 --> 02:47:02,181 PROJECT, THE COMMUNITY DIDN'T 4201 02:47:02,181 --> 02:47:03,916 WAIT UNTIL NEXT GEN SEQUENCING 4202 02:47:03,916 --> 02:47:05,084 AND VERY SOPHISTICATED TOOLS 4203 02:47:05,084 --> 02:47:06,318 THAT WE CURRENTLY HAVE 4204 02:47:06,318 --> 02:47:06,919 AVAILABLE, ONCE THOSE WERE 4205 02:47:06,919 --> 02:47:09,321 AVAILABLE THEY STARTED WITH THE 4206 02:47:09,321 --> 02:47:10,255 TECHNOLOGIES THAT WERE AVAILABLE 4207 02:47:10,255 --> 02:47:11,523 AT THE TIME. 4208 02:47:11,523 --> 02:47:12,858 ALL AROUND YOU'RE GETTING BEYOND 4209 02:47:12,858 --> 02:47:14,426 ONE GENE AT A TIME, SO MANY OF 4210 02:47:14,426 --> 02:47:19,765 YOU MAY REMEMBER SOME OF THOSE 4211 02:47:19,765 --> 02:47:21,500 cDNA SPOTS ON MICROSCOPE 4212 02:47:21,500 --> 02:47:22,601 SLIDES, PRIMITIVE COMPARED TO 4213 02:47:22,601 --> 02:47:25,070 TODAY WITH RNAseq. 4214 02:47:25,070 --> 02:47:28,140 BUT NEVERTHELESS A START, THE 4215 02:47:28,140 --> 02:47:29,775 WAY TO START COLLECTING DATA 4216 02:47:29,775 --> 02:47:31,443 BEYOND ONE GENE AT A TIME, WE 4217 02:47:31,443 --> 02:47:32,911 WANT TO DO THE SAME THING NOW 4218 02:47:32,911 --> 02:47:34,513 WITH THE EXPOSOME. 4219 02:47:34,513 --> 02:47:37,816 WE HAVE SOME REMARKABLE 4220 02:47:37,816 --> 02:47:38,317 CAPABILITIES. 4221 02:47:38,317 --> 02:47:48,794 HIGH RESOLUTION MASS SPEC 4222 02:47:49,528 --> 02:47:52,231 TROMETRY, LOOKING AT A SAMPLE OF 4223 02:47:52,231 --> 02:47:52,431 BLOOD. 4224 02:47:52,431 --> 02:47:54,933 THIS REQUIRES UNPRECEDENTED 4225 02:47:54,933 --> 02:47:55,667 DEGREE OF INTERNATIONAL 4226 02:47:55,667 --> 02:47:55,968 COOPERATION. 4227 02:47:55,968 --> 02:48:00,205 HAVING GROWN UP DURING THE 4228 02:48:00,205 --> 02:48:03,575 GENOME PROJECT ERA, I REMEMBER 4229 02:48:03,575 --> 02:48:04,710 THAT IT STARTED OFF, EVERYONE 4230 02:48:04,710 --> 02:48:06,278 WAS COMPETING. 4231 02:48:06,278 --> 02:48:08,213 ONE SEQUENCING CENTER AT ONE 4232 02:48:08,213 --> 02:48:09,348 INSTITUTION COMPETING WITH 4233 02:48:09,348 --> 02:48:10,015 ANOTHER SEQUENCING CENTER. 4234 02:48:10,015 --> 02:48:13,619 THE U.S. WAS COMPETING WITH 4235 02:48:13,619 --> 02:48:14,419 OTHER COUNTRIES. 4236 02:48:14,419 --> 02:48:20,159 AND ACTUALLY IT WAS ONLY ONCE, 4237 02:48:20,159 --> 02:48:21,059 TO FRANCIS COLLINS'S CREDIT, 4238 02:48:21,059 --> 02:48:22,461 ONCE HE BROUGHT THE 4239 02:48:22,461 --> 02:48:24,296 INTERNATIONAL COMMUNITY AND 4240 02:48:24,296 --> 02:48:30,202 STARTED THEM WORKING IN SYNC WE 4241 02:48:30,202 --> 02:48:31,270 STARTED MAKING PROGRESS, THE 4242 02:48:31,270 --> 02:48:32,204 HUMAN GENOME WAS PUBLISHED IN 4243 02:48:32,204 --> 02:48:32,471 2001. 4244 02:48:32,471 --> 02:48:34,139 THESE ARE THE COMPONENTS WE 4245 02:48:34,139 --> 02:48:34,907 NEED. 4246 02:48:34,907 --> 02:48:36,341 THIS IS WHAT'S HAPPENING 4247 02:48:36,341 --> 02:48:38,911 CURRENTLY DOWNTOWN IN D.C. 4248 02:48:38,911 --> 02:48:42,848 AND SO WE ARE HOPEFULLY HAVING 4249 02:48:42,848 --> 02:48:44,216 SOME DETAILS COMING OUT, WHAT 4250 02:48:44,216 --> 02:48:46,685 THE EXPOSOME -- WHAT WOULD A 4251 02:48:46,685 --> 02:48:47,252 HUMAN EXPOSOME PROJECT LOOK 4252 02:48:47,252 --> 02:48:50,022 LIKE, WHAT ARE THE COMPONENTS. 4253 02:48:50,022 --> 02:48:51,190 NEXT SLIDE PLEASE. 4254 02:48:51,190 --> 02:48:53,091 AND SO ONE OF THE MOST IMPORTANT 4255 02:48:53,091 --> 02:48:55,427 THINGS THAT WE NEEDED RIGHT OFF 4256 02:48:55,427 --> 02:48:59,264 THE BAT IS WE NEEDED TO CHARGE 4257 02:48:59,264 --> 02:49:01,333 SOMEONE WITH THE RESPONSIBILITY 4258 02:49:01,333 --> 02:49:02,434 TO BRING THE GLOBAL COMMUNITY 4259 02:49:02,434 --> 02:49:04,636 TOGETHER AND DEVELOP THIS 4260 02:49:04,636 --> 02:49:06,972 FRAMEWORK, AND SO WITH THE 4261 02:49:06,972 --> 02:49:07,673 GENEROUS CONTRIBUTIONS COMING 4262 02:49:07,673 --> 02:49:11,476 FROM SEVERAL I.C.s, INCLUDING 4263 02:49:11,476 --> 02:49:13,545 NINDS, NIEHS TOOK THE LEAD AND 4264 02:49:13,545 --> 02:49:15,681 WE'RE FUNDING WHAT WE'RE CALLING 4265 02:49:15,681 --> 02:49:17,249 THE NEXUS CENTER, THE NETWORK 4266 02:49:17,249 --> 02:49:21,787 FOR EXPOSOMICS IN THE U.S. 4267 02:49:21,787 --> 02:49:25,724 AND THIS IS AN AWARD THAT WAS 4268 02:49:25,724 --> 02:49:26,358 GIVEN TO COLUMBIA, HARVARD, AND 4269 02:49:26,358 --> 02:49:28,193 UNIVERSITY OF SOUTHERN 4270 02:49:28,193 --> 02:49:28,660 CALIFORNIA. 4271 02:49:28,660 --> 02:49:30,762 IT'S REALLY ABOUT BUILDING A 4272 02:49:30,762 --> 02:49:31,964 GLOBAL COMMUNITY OF PRACTICE 4273 02:49:31,964 --> 02:49:35,100 WHERE COOPERATION AND 4274 02:49:35,100 --> 02:49:36,368 COLLABORATION, NOTABLY IN 4275 02:49:36,368 --> 02:49:38,136 COORDINATION WITH THE EUROPEAN 4276 02:49:38,136 --> 02:49:40,205 HUMAN EXPOSOME NETWORK. 4277 02:49:40,205 --> 02:49:43,408 THE FOLKS ACROSS EUROPE ARE 4278 02:49:43,408 --> 02:49:45,210 PRETTY SOPHISTICATED IN WORKING 4279 02:49:45,210 --> 02:49:47,179 ON THE WHOLE EXPOSOME FRAMEWORK. 4280 02:49:47,179 --> 02:49:48,413 WE NEED THIS CONCEPTUAL 4281 02:49:48,413 --> 02:49:48,680 FRAMEWORK. 4282 02:49:48,680 --> 02:49:50,716 WE NEED TO THINK ABOUT THE 4283 02:49:50,716 --> 02:49:51,283 TECHNOLOGIES, METHODS, DATA 4284 02:49:51,283 --> 02:49:53,418 SHARING THAT WILL BE NECESSARY 4285 02:49:53,418 --> 02:49:56,188 TO MAKE THIS HAPPEN, AND REALLY 4286 02:49:56,188 --> 02:49:58,624 CAPITALIZE ON EXISTING EXPOSOME 4287 02:49:58,624 --> 02:49:59,591 RESEARCH INITIATIVES, 4288 02:49:59,591 --> 02:50:04,730 INFRASTRUCTURES, AND RESOURCES. 4289 02:50:04,730 --> 02:50:06,765 NEXT SLIDE PLEASE. 4290 02:50:06,765 --> 02:50:09,201 I'LL END HERE TO HAND OFF TO 4291 02:50:09,201 --> 02:50:09,401 DAVID. 4292 02:50:09,401 --> 02:50:16,208 IT'S WHERE WE WANT TO BE, MOST 4293 02:50:16,208 --> 02:50:18,443 THINGS ARE GENE BY ENVIRONMENT 4294 02:50:18,443 --> 02:50:19,745 EFFECTS, NEITHER GENETICS NOR 4295 02:50:19,745 --> 02:50:24,216 ENVIRONMENT ALONE IS GOING TO 4296 02:50:24,216 --> 02:50:25,517 EXPLAIN THE DISEASE OUTCOMES, OR 4297 02:50:25,517 --> 02:50:27,486 SUSCEPTIBILITY TO DISEASE SO WE 4298 02:50:27,486 --> 02:50:29,554 NEED TO DEVELOP THIS NEW 4299 02:50:29,554 --> 02:50:30,956 FRAMEWORK WHERE WE CAN CATALOG 4300 02:50:30,956 --> 02:50:34,293 THE EXPOSOME AND THEN WE HAVE 4301 02:50:34,293 --> 02:50:35,761 EXPOSOME SCIENTISTS WORKING 4302 02:50:35,761 --> 02:50:37,996 TOGETHER WITH GENOME SCIENTISTS, 4303 02:50:37,996 --> 02:50:39,531 WORKING IN COLLABORATION TO 4304 02:50:39,531 --> 02:50:41,166 ULTIMATELY TEASE OUT SOME OF THE 4305 02:50:41,166 --> 02:50:42,768 GENE BY ENVIRONMENT EFFECTS. 4306 02:50:42,768 --> 02:50:44,202 GENE BY ENVIRONMENT EFFECTS ARE 4307 02:50:44,202 --> 02:50:46,305 NOT EASY BECAUSE THE GENE 4308 02:50:46,305 --> 02:50:48,774 EFFECTS ARE NOT SINGLE GENE 4309 02:50:48,774 --> 02:50:49,207 EFFECTS. 4310 02:50:49,207 --> 02:50:52,244 THEY ARE COMPLEX TRAITS IN MOST 4311 02:50:52,244 --> 02:50:52,444 CASES. 4312 02:50:52,444 --> 02:50:55,047 SO NEXT SLIDE. 4313 02:50:55,047 --> 02:50:58,617 I'M VERY HAPPY TO SAY, NEXT 4314 02:50:58,617 --> 02:50:59,251 SLIDE, THAT -- ACTUALLY WALTER 4315 02:50:59,251 --> 02:51:01,853 KNOWS THIS WELL THAT THE JOSH 4316 02:51:01,853 --> 02:51:03,288 DENNY AND GEOFF GINSBERG AT THE 4317 02:51:03,288 --> 02:51:05,357 "ALL OF US" PROGRAM HAVE COME TO 4318 02:51:05,357 --> 02:51:06,825 REALLY UNDERSTAND AND EMBRACE 4319 02:51:06,825 --> 02:51:11,496 THE NOTION THAT IF WE TRULY WANT 4320 02:51:11,496 --> 02:51:12,764 TO ENABLE PRECISION MEDICINE, WE 4321 02:51:12,764 --> 02:51:14,266 HAVE TO ADD THE ENVIRONMENTAL 4322 02:51:14,266 --> 02:51:17,135 DATA SLICE TO THAT PIE. 4323 02:51:17,135 --> 02:51:20,272 SO, WE'RE STARTING OFF WITH 4324 02:51:20,272 --> 02:51:21,773 QUESTIONNAIRE DATA, AND GIS 4325 02:51:21,773 --> 02:51:23,709 DATA, AND WE ARE WORKING WITH 4326 02:51:23,709 --> 02:51:26,211 THEM NOW IN A PILOT EXPERIMENT, 4327 02:51:26,211 --> 02:51:28,413 TYPE 2 DIABETES, WHERE WE WILL 4328 02:51:28,413 --> 02:51:30,015 BRING A MORE SOPHISTICATED 4329 02:51:30,015 --> 02:51:33,952 EXPOSOMICS DATASET TO BEAR ON 4330 02:51:33,952 --> 02:51:34,186 THAT. 4331 02:51:34,186 --> 02:51:35,320 SO NEXT SLIDE. 4332 02:51:35,320 --> 02:51:37,856 I'LL FINISH UP HERE BY CALLING 4333 02:51:37,856 --> 02:51:39,891 TO ALL OF YOUR ATTENTION A 4334 02:51:39,891 --> 02:51:42,761 RECENT PUBLICATION THAT CAME OUT 4335 02:51:42,761 --> 02:51:47,165 A FEW WEEKS AGO IN SCIENCE 4336 02:51:47,165 --> 02:51:48,734 MAGAZINE FROM THE DANBURY 4337 02:51:48,734 --> 02:51:51,503 CONFERENCE IN NOVEMBER OF 2023, 4338 02:51:51,503 --> 02:51:53,005 THE PARTICIPANTS ARE SHOWN AT 4339 02:51:53,005 --> 02:51:55,507 THE BOTTOM HERE ON THIS SLIDE, 4340 02:51:55,507 --> 02:51:56,775 THE IDEA WAS AT THAT CONFERENCE 4341 02:51:56,775 --> 02:51:59,644 TO COME UP WITH A DEFINITION OF 4342 02:51:59,644 --> 02:52:01,446 WHAT IS THE EXPOSOME. 4343 02:52:01,446 --> 02:52:02,814 SO, I ENCOURAGE YOU TO TAKE A 4344 02:52:02,814 --> 02:52:05,183 LOOK AT THE PAPER. 4345 02:52:05,183 --> 02:52:07,119 THE PAPER ENDS WITH THE 4346 02:52:07,119 --> 02:52:09,254 STATEMENT THAT LIFE EXISTS AT 4347 02:52:09,254 --> 02:52:10,355 THE INTERFACE OF GENETICALLY 4348 02:52:10,355 --> 02:52:12,190 ENCODED PROCESS AND 4349 02:52:12,190 --> 02:52:15,160 ENVIRONMENTALLY DRIVEN 4350 02:52:15,160 --> 02:52:15,427 REALITIES. 4351 02:52:15,427 --> 02:52:16,928 SO TOO SHOULD THE BIOMEDICAL 4352 02:52:16,928 --> 02:52:18,430 ENTERPRISE THAT STUDIES IT. 4353 02:52:18,430 --> 02:52:21,166 SO, THAT'S WHERE WE ARE. 4354 02:52:21,166 --> 02:52:24,569 SO, DAVID, I THINK I'M HANDING 4355 02:52:24,569 --> 02:52:30,475 OFF TO YOU NOW, IS THAT RIGHT? 4356 02:52:30,475 --> 02:52:31,777 >> I THINK SO. 4357 02:52:31,777 --> 02:52:35,781 >> WE CAN HEAR YOU, YES. 4358 02:52:35,781 --> 02:52:44,189 >> SO, YEAH -- YOU MAY SEE SOME 4359 02:52:44,189 --> 02:52:45,657 THINGS THAT LOOK LIKE WHAT HE'S 4360 02:52:45,657 --> 02:52:48,193 DONE BUT THAT'S FINE BECAUSE THE 4361 02:52:48,193 --> 02:52:51,063 MORE THE MERRIER. 4362 02:52:51,063 --> 02:52:54,132 SO, ANYWAY, I JUST FIRST WANT TO 4363 02:52:54,132 --> 02:52:55,700 SAY, YOU KNOW, HELLO TO 4364 02:52:55,700 --> 02:52:57,736 EVERYBODY. 4365 02:52:57,736 --> 02:53:00,505 I ALSO WANT TO THANK DR. WOYCHIK 4366 02:53:00,505 --> 02:53:05,644 FOR TAKING TIME FOR LETTING US 4367 02:53:05,644 --> 02:53:11,616 HEAR ABOUT NIEHS AND THE 4368 02:53:11,616 --> 02:53:13,552 IMPORTANT WORK OF THE PAST 4369 02:53:13,552 --> 02:53:16,054 SEVERAL YEARS, IT HASN'T JUST 4370 02:53:16,054 --> 02:53:16,288 STARTED. 4371 02:53:16,288 --> 02:53:22,594 WE DO LEARN A LOT ABOUT THIS, 4372 02:53:22,594 --> 02:53:26,731 ESPECIALLY THE IMPORTANCE OF 4373 02:53:26,731 --> 02:53:27,199 COLLABORATION. 4374 02:53:27,199 --> 02:53:30,235 IT'S DEFINITELY ESSENTIAL. 4375 02:53:30,235 --> 02:53:32,404 SO ANYWAY, I'M DAVE JETT, 4376 02:53:32,404 --> 02:53:35,207 DIRECTOR OF OFFICE OF NEURAL 4377 02:53:35,207 --> 02:53:39,244 EXPOSOME AND TOXICOLOGY, WITHIN 4378 02:53:39,244 --> 02:53:41,046 THE DTR, SERVES ALL OF NINDS. 4379 02:53:41,046 --> 02:53:43,582 I ALSO WANT TO INTRODUCE OUR 4380 02:53:43,582 --> 02:53:51,656 SENIOR PROGRAM OFFICER, IN OUR 4381 02:53:51,656 --> 02:53:55,260 OFFICE, DR. SHARDELL SPRIGGS, 4382 02:53:55,260 --> 02:53:58,730 THE CHEMICAL THREATS PROGRAM AND 4383 02:53:58,730 --> 02:53:59,898 OTHER THINGS. 4384 02:53:59,898 --> 02:54:04,202 SO TODAY FOR OUR AGENDA REALLY 4385 02:54:04,202 --> 02:54:07,639 IS OVER THE NEXT MAYBE 15 4386 02:54:07,639 --> 02:54:10,942 MINUTES OR SO, AND I WILL GIVE A 4387 02:54:10,942 --> 02:54:14,346 SHORT TALK ABOUT THE NEURAL 4388 02:54:14,346 --> 02:54:16,982 EXPOSOME AND WHY WE'RE WORKING 4389 02:54:16,982 --> 02:54:19,184 WITH IT. 4390 02:54:19,184 --> 02:54:23,255 AND THEN I WILL TURN IT OVER TO 4391 02:54:23,255 --> 02:54:25,857 DR. SPRIGGS WHO WILL LEAD THE 4392 02:54:25,857 --> 02:54:28,493 WORKING GROUP THAT WORKED ON THE 4393 02:54:28,493 --> 02:54:33,331 TOP PRIORITIES THAT COUNCIL 4394 02:54:33,331 --> 02:54:35,834 DEVELOPED LAST YEAR. 4395 02:54:35,834 --> 02:54:43,041 AND WILL GIVE YOU MORE 4396 02:54:43,041 --> 02:54:44,209 INFORMATION ON RECOMMENDATION 4397 02:54:44,209 --> 02:54:48,079 IMPLEMENTATION ACTIVITIES. 4398 02:54:48,079 --> 02:54:49,981 SO, NEXT SLIDE. 4399 02:54:49,981 --> 02:54:53,385 YEAH, SO WHAT'S THE EXPOSOME? 4400 02:54:53,385 --> 02:54:57,522 AND I'LL SAY SO WE KNOW THE 4401 02:54:57,522 --> 02:55:00,192 IMPORTANCE OF GENETICS IN 4402 02:55:00,192 --> 02:55:03,295 DISEASE ETIOLOGY, BUT -- AND I 4403 02:55:03,295 --> 02:55:05,497 WOULD SAY THAT, YOU KNOW, IT'S 4404 02:55:05,497 --> 02:55:06,198 DEFINITELY IMPORTANT. 4405 02:55:06,198 --> 02:55:08,033 NOT LIKE IT'S NOT IMPORTANT OR 4406 02:55:08,033 --> 02:55:10,735 ANYTHING LIKE THAT. 4407 02:55:10,735 --> 02:55:12,337 BUT ACTUALLY MOST DISEASES 4408 02:55:12,337 --> 02:55:15,373 CANNOT BE EXPLAINED BY GENETICS 4409 02:55:15,373 --> 02:55:16,174 ALONE. 4410 02:55:16,174 --> 02:55:20,212 SO THERE MUST BE OTHER FACTORS. 4411 02:55:20,212 --> 02:55:25,850 THESE FACTORS ARE THE EXPOSOME. 4412 02:55:25,850 --> 02:55:31,823 AND IT HAS A DEFINITION OF AS 4413 02:55:31,823 --> 02:55:37,729 THE INTEGRATED COMPILATION OF 4414 02:55:37,729 --> 02:55:41,132 ALL PHYSICAL AND BIOLOGICAL AND 4415 02:55:41,132 --> 02:55:43,835 PSYCHOSOCIAL AND CHEMICAL 4416 02:55:43,835 --> 02:55:46,304 INFLUENCES THAT IMPACT OUR 4417 02:55:46,304 --> 02:55:46,538 BIOLOGY. 4418 02:55:46,538 --> 02:55:49,674 SO, WE BELIEVE THAT STUDYING 4419 02:55:49,674 --> 02:55:52,210 THESE EXPOSOME FACTORS COULD 4420 02:55:52,210 --> 02:55:56,214 HELP UNLOCK THE CAUSES AND 4421 02:55:56,214 --> 02:56:06,658 PREVENT DISEASES AND POOR 4422 02:56:07,025 --> 02:56:07,192 HEALTH. 4423 02:56:07,192 --> 02:56:07,926 OKAY. 4424 02:56:07,926 --> 02:56:10,595 SO, FOR NINDS, WE FOCUS ON THE 4425 02:56:10,595 --> 02:56:12,330 NEURAL EXPOSOME FACTORS THAT 4426 02:56:12,330 --> 02:56:16,635 HAVE AN IMPACT ON OBVIOUSLY 4427 02:56:16,635 --> 02:56:18,570 NEUROLOGICAL DISEASES AND 4428 02:56:18,570 --> 02:56:20,071 DISORDERS. 4429 02:56:20,071 --> 02:56:28,013 AND THE NEURAL EXPOSOME INCLUDES 4430 02:56:28,013 --> 02:56:31,783 EXOGENOUS RISK FACTORS, ALSO 4431 02:56:31,783 --> 02:56:33,318 ENDOGENOUS LIKE MICROBIOME, 4432 02:56:33,318 --> 02:56:34,419 EPIGENETICS IS ABSOLUTELY 4433 02:56:34,419 --> 02:56:35,854 IMPORTANT. 4434 02:56:35,854 --> 02:56:38,323 AND BEHAVIORAL RISK FACTORS LIKE 4435 02:56:38,323 --> 02:56:41,092 SLEEP AND OF COURSE PSYCHOSOCIAL 4436 02:56:41,092 --> 02:56:44,663 KINDS OF THINGS. 4437 02:56:44,663 --> 02:56:47,399 SO, WE BELIEVE THAT, WELL, WE 4438 02:56:47,399 --> 02:56:49,434 BELIEVE THAT THESE HAVE SOME -- 4439 02:56:49,434 --> 02:56:53,338 IF NOT A LARGE EFFECT ON, IT IS 4440 02:56:53,338 --> 02:56:56,074 AN EFFECT ON NEUROLOGICAL 4441 02:56:56,074 --> 02:56:58,910 DISORDERS AND STROKE. 4442 02:56:58,910 --> 02:56:59,344 OKAY. 4443 02:56:59,344 --> 02:57:00,912 SO NEXT SLIDE. 4444 02:57:00,912 --> 02:57:05,817 SO FOR THIS ONE, WE DID THIS 4445 02:57:05,817 --> 02:57:08,219 GENERAL ASSESSMENT OF THE 4446 02:57:08,219 --> 02:57:10,488 LANDSCAPE OF NEURAL EXPOSOME 4447 02:57:10,488 --> 02:57:12,090 RESEARCH FUNDED BY NIH. 4448 02:57:12,090 --> 02:57:18,263 THANKS TO HEALTH PROGRAM 4449 02:57:18,263 --> 02:57:19,230 SPECIALIST DR. CLAUDIA FIGAR 4450 02:57:19,230 --> 02:57:21,733 DEMROE FOR THIS WORK. 4451 02:57:21,733 --> 02:57:26,104 AND LESS THAN 1% OF ALL NIH 4452 02:57:26,104 --> 02:57:31,076 AWARD GRANTS DURING THE PAST 4453 02:57:31,076 --> 02:57:35,347 SEVEN YEARS WERE NEURAL EXPOSOME 4454 02:57:35,347 --> 02:57:35,747 RESEARCH, 1%. 4455 02:57:35,747 --> 02:57:41,720 FOR NINDS, WE FUNDED ONLY 36 4456 02:57:41,720 --> 02:57:43,555 GRANTS OVER THAT PERIOD, AND 4457 02:57:43,555 --> 02:57:46,224 THESE COVERED ONLY A VERY SMALL 4458 02:57:46,224 --> 02:57:48,526 NUMBER OF DISEASES, IF YOU LOOK 4459 02:57:48,526 --> 02:57:53,264 AT THAT, SEE THAT IS JUST A 4460 02:57:53,264 --> 02:57:54,432 SMALL NUMBER. 4461 02:57:54,432 --> 02:57:57,102 SO WE NEED MORE RESEARCH AND 4462 02:57:57,102 --> 02:57:58,903 MORE DIVERSE RESEARCH TO MEET 4463 02:57:58,903 --> 02:58:00,939 OUR MISSION TO REDUCE BURDEN OF 4464 02:58:00,939 --> 02:58:06,378 NEUROLOGICAL DISEASES AND FOR 4465 02:58:06,378 --> 02:58:13,685 ALL PEOPLE NEXT SLIDE. 4466 02:58:13,685 --> 02:58:18,056 SO, YEAH, SO LAST SEPTEMBER OR 4467 02:58:18,056 --> 02:58:18,723 COUNCIL NEUROEXPOSOME WORKING 4468 02:58:18,723 --> 02:58:20,592 GROUP DEVELOPED PRIORITY AREAS 4469 02:58:20,592 --> 02:58:25,196 FOR NEUROEXPOSOME RESEARCH AT 4470 02:58:25,196 --> 02:58:25,697 NINDS. 4471 02:58:25,697 --> 02:58:27,532 SO, DEFINITELY WANT TO THANK 4472 02:58:27,532 --> 02:58:30,268 THEM FOR ALL THEIR HARD WORK AND 4473 02:58:30,268 --> 02:58:32,070 VERY THOROUGH REPORT THAT THEY 4474 02:58:32,070 --> 02:58:34,205 DID, AND THE TOP PRIORITIES THAT 4475 02:58:34,205 --> 02:58:39,544 YOU'LL SEE IN THE NEXT SLIDES. 4476 02:58:39,544 --> 02:58:42,547 I WANT TO ESPECIALLY LIKE TO 4477 02:58:42,547 --> 02:58:44,716 THANK DR. PAM LYONS, THE CHAIR 4478 02:58:44,716 --> 02:58:49,988 OF THE WORKING GROUP, AND THEN 4479 02:58:49,988 --> 02:58:57,762 WE HAD DR. GINA POE AND DR. 4480 02:58:57,762 --> 02:59:08,006 RILEY AS REPRESENTATIVES FOR THE 4481 02:59:08,006 --> 02:59:08,406 COUNCIL. 4482 02:59:08,406 --> 02:59:12,110 SO THESE ARE THE -- OH. 4483 02:59:12,110 --> 02:59:13,344 YEAH, THESE ARE THE SIX 4484 02:59:13,344 --> 02:59:15,447 PRIORITIES THAT THE COUNCIL 4485 02:59:15,447 --> 02:59:18,416 WORKING GROUP DEVELOPED, 4486 02:59:18,416 --> 02:59:19,884 STARTING WITH THESE THREE PARTS, 4487 02:59:19,884 --> 02:59:26,458 THE FIRST THING WE MUST DO IS 4488 02:59:26,458 --> 02:59:31,129 IDENTIFY THE EXPOSOME FACTORS 4489 02:59:31,129 --> 02:59:31,896 THAT ARE RELEVANT TO 4490 02:59:31,896 --> 02:59:33,765 NEUROLOGICAL HEALTH. 4491 02:59:33,765 --> 02:59:42,874 FOR THE SECOND MECHANISTIC 4492 02:59:42,874 --> 02:59:44,209 RESEARCH HOW THEY INFLUENCE AND 4493 02:59:44,209 --> 02:59:46,611 FINALLY DONE WITH THE 4494 02:59:46,611 --> 02:59:48,146 APPROPRIATE HUMAN POPULATIONS. 4495 02:59:48,146 --> 02:59:53,852 THEN THE NEXT ONE IN RED AND 4496 02:59:53,852 --> 02:59:56,688 YELLOW -- RED AND YELLOW? 4497 02:59:56,688 --> 02:59:57,922 YEAH. 4498 02:59:57,922 --> 03:00:00,191 AND THESE ARE THE FOCUS ON THE 4499 03:00:00,191 --> 03:00:03,995 PEOPLE WHO WILL DO THIS 4500 03:00:03,995 --> 03:00:07,031 RESEARCH, AND THE RESOURCES AND 4501 03:00:07,031 --> 03:00:09,634 TOOLS THAT THEY WILL NEED. 4502 03:00:09,634 --> 03:00:14,973 AND THE LAST ONE, BURGUNDY I 4503 03:00:14,973 --> 03:00:18,610 BELIEVE, YEAH, OKAY, IS ON THE 4504 03:00:18,610 --> 03:00:20,612 IMPORTANCE OF COLLABORATION AND 4505 03:00:20,612 --> 03:00:21,012 PARTNERSHIP. 4506 03:00:21,012 --> 03:00:24,849 SO WITH THAT, I THINK WE CAN GO 4507 03:00:24,849 --> 03:00:27,819 AHEAD NOW AND FIND THE GOOD 4508 03:00:27,819 --> 03:00:30,955 STUFF WITH DR. SPRIGGS. 4509 03:00:30,955 --> 03:00:41,099 THANKS. 4510 03:00:44,035 --> 03:00:54,412 >> THANKS, DAVE. 4511 03:00:54,412 --> 03:00:56,281 ALL RIGHT. 4512 03:00:56,281 --> 03:00:57,582 THANK YOU, DR. JETT. 4513 03:00:57,582 --> 03:00:59,250 GOOD AFTERNOON, EVERYONE. 4514 03:00:59,250 --> 03:01:01,753 I'M EXCITED TO BE HERE. 4515 03:01:01,753 --> 03:01:03,321 AND APPRECIATE THE OPPORTUNITY 4516 03:01:03,321 --> 03:01:06,391 TO DISCUSS OUR PROPOSED 4517 03:01:06,391 --> 03:01:07,191 IMPLEMENTATION PLAN. 4518 03:01:07,191 --> 03:01:09,794 SO NINDS FIRST FORMED A WORKING 4519 03:01:09,794 --> 03:01:12,196 GROUP THAT REFLECTED ON THOSE 4520 03:01:12,196 --> 03:01:14,332 SIX PRIORITY AREAS, AND THEN 4521 03:01:14,332 --> 03:01:16,200 DEVELOPED ACTIONABLE STEPS TO 4522 03:01:16,200 --> 03:01:18,803 IMPLEMENT NEURAL EXPOSOME 4523 03:01:18,803 --> 03:01:19,203 RESEARCH PROGRAM. 4524 03:01:19,203 --> 03:01:25,543 TODAY I'M PRESENTING ON BEHALF 4525 03:01:25,543 --> 03:01:26,411 OF THAT WORKING GROUP. 4526 03:01:26,411 --> 03:01:33,484 SARA DODSON AND KAT LEBLANC ARE 4527 03:01:33,484 --> 03:01:35,420 NO LONGER THERE BUT WE THANK THE 4528 03:01:35,420 --> 03:01:36,621 MEMBERS THUS FAR. 4529 03:01:36,621 --> 03:01:38,656 AFTER CAREFULLY STUDYING THE 4530 03:01:38,656 --> 03:01:40,291 REPORT IMPLEMENTATION WORKING 4531 03:01:40,291 --> 03:01:42,994 GROUP IDENTIFIED FIVE AREAS FOR 4532 03:01:42,994 --> 03:01:45,763 US TO FOCUS OUR INITIAL EFFORTS, 4533 03:01:45,763 --> 03:01:46,364 WE'LL FOSTER PARTNERSHIPS WITH 4534 03:01:46,364 --> 03:01:49,467 OTHERS THAT ARE WORKING IN THIS 4535 03:01:49,467 --> 03:01:52,170 SPACE, AND WORK TO AMPLIFY THE 4536 03:01:52,170 --> 03:01:53,304 MESSAGE THAT NINDS IS INTERESTED 4537 03:01:53,304 --> 03:01:56,274 AND COMMITTED TO NEURAL EXPOSOME 4538 03:01:56,274 --> 03:01:56,641 RESEARCH. 4539 03:01:56,641 --> 03:01:59,177 TO NOT REINVENT THE WHEEL, WE'RE 4540 03:01:59,177 --> 03:02:00,878 GOING TO LEVERAGE EXISTING 4541 03:02:00,878 --> 03:02:01,980 RESOURCES AND TOOLS TO JUMP 4542 03:02:01,980 --> 03:02:03,481 START OUR PROGRAM. 4543 03:02:03,481 --> 03:02:06,818 AND I IDENTIFY AREAS WHERE SMALL 4544 03:02:06,818 --> 03:02:08,086 INVESTMENTS CAN HAVE MEANINGFUL 4545 03:02:08,086 --> 03:02:09,120 IMPACT. 4546 03:02:09,120 --> 03:02:13,291 WE'LL TRAIN INVESTIGATORS AND 4547 03:02:13,291 --> 03:02:14,292 CONDUCT EXPOSOME RESEARCH, 4548 03:02:14,292 --> 03:02:15,960 RECRUIT MORE NEURAL SCIENTISTS 4549 03:02:15,960 --> 03:02:18,096 AND BUILD MULTI-DISCIPLINARY 4550 03:02:18,096 --> 03:02:20,098 TEAMS THAT CAN TACKLE WHAT CAN 4551 03:02:20,098 --> 03:02:21,733 BE COMPLICATED RESEARCH GAINS. 4552 03:02:21,733 --> 03:02:23,501 WE WANT TO CONVENE WORKSHOPS AND 4553 03:02:23,501 --> 03:02:25,403 OTHER MEETINGS TO PROVIDE A 4554 03:02:25,403 --> 03:02:26,838 FORUM FOR HAVING FOCUSED 4555 03:02:26,838 --> 03:02:28,039 DISCUSSIONS ON THE STATE OF THE 4556 03:02:28,039 --> 03:02:30,842 SCIENCE AS WELL AS EVOLVING 4557 03:02:30,842 --> 03:02:32,010 RESEARCH GAPS AND CHALLENGES. 4558 03:02:32,010 --> 03:02:34,112 WE'RE GOING TO SUPPORT NEURAL 4559 03:02:34,112 --> 03:02:34,912 EXPOSOME RESEARCH IN THE 4560 03:02:34,912 --> 03:02:36,180 EXTRAMURAL COMMUNITY. 4561 03:02:36,180 --> 03:02:38,249 AND THIS WILL LEAD TO DISCOVERY 4562 03:02:38,249 --> 03:02:39,417 OF NEW THERAPEUTIC APPROACHES 4563 03:02:39,417 --> 03:02:41,886 THAT WILL LOWER THE RISK OF 4564 03:02:41,886 --> 03:02:43,554 NEUROLOGICAL DISORDERS AND 4565 03:02:43,554 --> 03:02:45,523 STROKE FOR EVERYONE. 4566 03:02:45,523 --> 03:02:46,591 NEXT SLIDE PLEASE. 4567 03:02:46,591 --> 03:02:55,767 SO IN OUR FIRST FOCUS AREA OF 4568 03:02:55,767 --> 03:02:58,469 FOSTERING PARTNERSHIPS WE'LL 4569 03:02:58,469 --> 03:03:02,006 BUILD AND STAIN PARTNERSHIPS 4570 03:03:02,006 --> 03:03:03,908 WITH NIH INSTITUTES, RESEARCH, 4571 03:03:03,908 --> 03:03:05,643 ACADEMIA, CLINICAL PRACTICE AS 4572 03:03:05,643 --> 03:03:08,279 WELL AS ADVOCACY GROUPS AND 4573 03:03:08,279 --> 03:03:09,414 PROFESSIONAL SOCIETIES, AND 4574 03:03:09,414 --> 03:03:12,183 REALLY ANYONE INTERESTED IN 4575 03:03:12,183 --> 03:03:13,484 WORKING ADJACENTLY TO NEURAL 4576 03:03:13,484 --> 03:03:16,187 EXPOSOME RESEARCH AS A FIRST 4577 03:03:16,187 --> 03:03:18,122 STEP, WE ESTABLISHED AN NIH 4578 03:03:18,122 --> 03:03:19,791 ENVIRONMENTAL NEUROSCIENCE 4579 03:03:19,791 --> 03:03:22,326 WORKING GROUP, CO-LED BY NIEHS, 4580 03:03:22,326 --> 03:03:25,063 THAT FUNCTIONS ACROSS NIH AS A 4581 03:03:25,063 --> 03:03:28,199 ROUNDTABLE TO DISCUSS INTRA AND 4582 03:03:28,199 --> 03:03:28,966 INTERINSTITUTIONAL INITIATIVES. 4583 03:03:28,966 --> 03:03:30,368 IN FACT, COLLABORATIONS WITHIN 4584 03:03:30,368 --> 03:03:33,504 THIS GROUP LED TO THE NINDS 4585 03:03:33,504 --> 03:03:36,674 CO-FUNDING OF THE NIEHS NEXUS 4586 03:03:36,674 --> 03:03:38,176 CENTER DR. WOYCHIK DISCUSSED. 4587 03:03:38,176 --> 03:03:44,015 TO AM AMPLIFY WE'LL LEVERAGE 4588 03:03:44,015 --> 03:03:47,652 SOCIETY FOR NEUROSCIENCE, TO 4589 03:03:47,652 --> 03:03:48,886 HOLD SYMPOSIA AND DISCUSS 4590 03:03:48,886 --> 03:03:49,987 IMPACTS OF EXPOSOME FACTORS ON 4591 03:03:49,987 --> 03:03:50,521 BRAIN HEALTH. 4592 03:03:50,521 --> 03:03:53,424 WE'LL PUBLISH FINDINGS FROM 4593 03:03:53,424 --> 03:03:54,659 THESE MEETINGS IN PEER-REVIEWED 4594 03:03:54,659 --> 03:03:56,194 JOURNALS TO MAKE SURE WE'RE 4595 03:03:56,194 --> 03:04:01,265 REACHING AS BROAD AN AUDIENCE AS 4596 03:04:01,265 --> 03:04:02,200 POSSIBLE. 4597 03:04:02,200 --> 03:04:03,835 WEBSITE INCLUDES A NEW MISSION 4598 03:04:03,835 --> 03:04:06,003 STATEMENT TO HIGHLIGHT THE 4599 03:04:06,003 --> 03:04:09,874 IMPORTANCE OF RESEARCH IN THIS 4600 03:04:09,874 --> 03:04:10,108 AREA. 4601 03:04:10,108 --> 03:04:11,275 NEXT SLIDE PLEASE. 4602 03:04:11,275 --> 03:04:12,710 WE'RE GOING TO LEVERAGE MANY 4603 03:04:12,710 --> 03:04:14,445 EXISTING RESOURCES AND TOOLS 4604 03:04:14,445 --> 03:04:17,348 THAT HAVE BEEN CULTIVATED BUT 4605 03:04:17,348 --> 03:04:19,784 ARE NOT YET EXTENSIVELY USED TO 4606 03:04:19,784 --> 03:04:23,988 CONDUCT NEURAL EXPOSOME 4607 03:04:23,988 --> 03:04:24,255 RESEARCH. 4608 03:04:24,255 --> 03:04:25,990 RESOURCES LIKE BIOAND DATA 4609 03:04:25,990 --> 03:04:27,859 REPOSITORY STUDIES, HUMAN COHORT 4610 03:04:27,859 --> 03:04:29,060 STUDIES WITH RICH AND 4611 03:04:29,060 --> 03:04:31,562 DECADES-LONG DATASETS PRIMED TO 4612 03:04:31,562 --> 03:04:33,898 BE ADAPTED TO EXPOSOME RESEARCH 4613 03:04:33,898 --> 03:04:34,665 STUDIES. 4614 03:04:34,665 --> 03:04:36,534 WE WILL SUPPORT INTEGRATION OF 4615 03:04:36,534 --> 03:04:38,636 EXPOSOME FACTORS INTO RESEARCH 4616 03:04:38,636 --> 03:04:42,106 PROJECTS, AND DEVELOP COMMON 4617 03:04:42,106 --> 03:04:45,510 DATA ELEMENTS TO FACILITATE DATA 4618 03:04:45,510 --> 03:04:46,010 COLLECTION. 4619 03:04:46,010 --> 03:04:47,578 MODEL SYSTEMS INTERROGATE 4620 03:04:47,578 --> 03:04:50,014 COMPLEX QUESTIONS, INCLUDING NEW 4621 03:04:50,014 --> 03:04:50,948 APPROACH METHODOLOGIES, AND 4622 03:04:50,948 --> 03:04:53,584 HUMAN RELEVANT ANIMAL MODELS AND 4623 03:04:53,584 --> 03:04:56,053 EXPOSURE SYSTEMS THAT APPROACH 4624 03:04:56,053 --> 03:04:59,757 THAT MID TO HIGH THROUGHPUT 4625 03:04:59,757 --> 03:05:01,893 RANGE ARE RAPIDLY EVOLVING. 4626 03:05:01,893 --> 03:05:03,561 NEW METHODS SUCH AS HIGH 4627 03:05:03,561 --> 03:05:05,897 RESOLUTION MASS SPEC NOW 4628 03:05:05,897 --> 03:05:07,932 GENERATING DATA ON AN OMICS 4629 03:05:07,932 --> 03:05:10,568 SCALE, TO THAT END DATA 4630 03:05:10,568 --> 03:05:12,770 TECHNOLOGY SUCH AS ARTIFICIAL 4631 03:05:12,770 --> 03:05:13,938 INTELLIGENCE, MACHINE LEARNING, 4632 03:05:13,938 --> 03:05:14,972 DATA SHARING PLATFORMS AND 4633 03:05:14,972 --> 03:05:16,107 MEASUREMENT SYSTEMS ARE MORE 4634 03:05:16,107 --> 03:05:17,809 IMPORTANT THAN EVER. 4635 03:05:17,809 --> 03:05:19,877 WE MUST LEVERAGE NOT ONLY WHAT 4636 03:05:19,877 --> 03:05:21,646 IS BEING FUNDED AT NIH BUT 4637 03:05:21,646 --> 03:05:26,884 ELSEWHERE AND BRING IT INTO THE 4638 03:05:26,884 --> 03:05:30,721 NEURAL EXPOSOME RESEARCH SPACE. 4639 03:05:30,721 --> 03:05:32,790 SO TRAINING INVESTIGATORS AND 4640 03:05:32,790 --> 03:05:36,794 BUILDING MULTI-DISCIPLINARY TEAM 4641 03:05:36,794 --> 03:05:37,929 ARE IMPORTANT COMPONENTS, TO 4642 03:05:37,929 --> 03:05:40,198 PROVIDE TRAINING AND CONDUCT 4643 03:05:40,198 --> 03:05:41,732 EXPOSOME RESEARCH AND FUND 4644 03:05:41,732 --> 03:05:43,301 TRAINING OPPORTUNITIES AT ALL 4645 03:05:43,301 --> 03:05:44,268 CAREER STAGES. 4646 03:05:44,268 --> 03:05:46,871 HANDLING COMPLEX DATA SUCH AS 4647 03:05:46,871 --> 03:05:47,605 INTEGRATED DISPARATE DATA 4648 03:05:47,605 --> 03:05:49,707 SOURCES TO BRIDGE EXPOSOME 4649 03:05:49,707 --> 03:05:51,309 FACTORS AND MAINTAIN RIGOR ARE 4650 03:05:51,309 --> 03:05:53,845 ALL AREAS THAT COULD BENEFIT 4651 03:05:53,845 --> 03:05:54,979 FROM GUIDELINES. 4652 03:05:54,979 --> 03:05:57,481 FOR NOW, WE CAN PUBLISH BEST 4653 03:05:57,481 --> 03:06:00,184 PRACTICES AND LEAN ON EXISTING 4654 03:06:00,184 --> 03:06:01,586 PROGRAMS THAT PROVIDE TRAINING 4655 03:06:01,586 --> 03:06:04,188 AND TEACH DATA ANALYSIS FOR 4656 03:06:04,188 --> 03:06:04,856 EXPOSOME RESEARCH. 4657 03:06:04,856 --> 03:06:07,258 LIKE THE EXPOSOME BOOT CAMP AT 4658 03:06:07,258 --> 03:06:07,792 COLUMBIA. 4659 03:06:07,792 --> 03:06:09,493 WE CAN ALSO PARTNER WITH 4660 03:06:09,493 --> 03:06:11,229 EXPOSOME INITIATIVES THAT 4661 03:06:11,229 --> 03:06:14,065 PROVIDE FUNDING SUPPORT AT THE 4662 03:06:14,065 --> 03:06:19,604 TRAINING LEVEL LIKE ECHO AND 4663 03:06:19,604 --> 03:06:21,105 CENTERS LIKE THE HERCULES CENTER 4664 03:06:21,105 --> 03:06:22,240 AT EMORY. 4665 03:06:22,240 --> 03:06:24,208 TRAINING GRANTS REPRESENT A 4666 03:06:24,208 --> 03:06:25,676 GREAT OPPORTUNITY TO BRING EARLY 4667 03:06:25,676 --> 03:06:26,944 STAGE INVESTIGATORS INTO THE 4668 03:06:26,944 --> 03:06:27,845 NEURAL EXPOSOME FIELD AND THEY 4669 03:06:27,845 --> 03:06:31,082 ARE LOOKING FOR A PLACE TO MAKE 4670 03:06:31,082 --> 03:06:32,049 THEIR MARK. 4671 03:06:32,049 --> 03:06:39,123 OVER THE RECENT YEARS NINDS 4672 03:06:39,123 --> 03:06:43,160 AWARDED 10% MUCH GRANTS, ON PAR 4673 03:06:43,160 --> 03:06:43,961 WITH NIH. 4674 03:06:43,961 --> 03:06:46,831 WHEN WE START TO THINK ABOUT THE 4675 03:06:46,831 --> 03:06:48,199 NUMBER OF THOSE TRAINEES THAT 4676 03:06:48,199 --> 03:06:50,935 ARE FOCUSED ON THE NEURAL 4677 03:06:50,935 --> 03:06:53,638 EXPOSOME, THAT LEVEL FALLS TO 4678 03:06:53,638 --> 03:06:55,973 WELL BELOW 1%, SO WE RECOGNIZE 4679 03:06:55,973 --> 03:06:57,642 THIS AS A CRITICAL GAP IN 4680 03:06:57,642 --> 03:06:59,410 OPPORTUNITY THAT WE CAN ADDRESS. 4681 03:06:59,410 --> 03:07:01,612 TO THAT END WE'RE IMPLEMENTING 4682 03:07:01,612 --> 03:07:04,215 THE NEURAL EXPOSOME ROAD SHOW 4683 03:07:04,215 --> 03:07:05,816 INITIATIVE, THIS IS AN OUTREACH 4684 03:07:05,816 --> 03:07:07,919 EFFORT WHERE OUR OFFICE IS 4685 03:07:07,919 --> 03:07:09,854 ENGAGING TRAINING PROGRAMS TO 4686 03:07:09,854 --> 03:07:11,289 LEARN MORE ABOUT WHAT'S NEEDED 4687 03:07:11,289 --> 03:07:14,091 AND AVAILABLE IN THIS AREA, AND 4688 03:07:14,091 --> 03:07:15,726 START TO BUILD THOSE 4689 03:07:15,726 --> 03:07:16,327 RELATIONSHIPS. 4690 03:07:16,327 --> 03:07:18,829 WE ALSO NEED TO BUILD 4691 03:07:18,829 --> 03:07:19,463 MULTI-DISCIPLINARY TEAMS. 4692 03:07:19,463 --> 03:07:21,899 SO WE CAN ADD EXPERTISE TO 4693 03:07:21,899 --> 03:07:23,734 EXISTING PROJECTS, AS WELL AS 4694 03:07:23,734 --> 03:07:25,002 ENCOURAGE TEAM SCIENCE 4695 03:07:25,002 --> 03:07:27,305 APPROACHES FOR NEW PROJECTS. 4696 03:07:27,305 --> 03:07:30,241 SO WHETHER IT'S COLLABORATION 4697 03:07:30,241 --> 03:07:33,210 WITH CLINICAL NEUROLOGISTS, 4698 03:07:33,210 --> 03:07:34,278 TOXICOLOGISTS, BIOSTATISTICIANS, 4699 03:07:34,278 --> 03:07:36,280 OR BASIC SCIENTISTS WITH 4700 03:07:36,280 --> 03:07:37,014 SPECIALIZED EXPERTISE WE WANT 4701 03:07:37,014 --> 03:07:39,417 THE RIGHT PEOPLE ON THE TEAM 4702 03:07:39,417 --> 03:07:42,153 BECAUSE AS WE KNOW, DIVERSITY OF 4703 03:07:42,153 --> 03:07:44,055 THOUGHT AND BACKGROUND INCREASES 4704 03:07:44,055 --> 03:07:48,426 OUR CHANCES OF SOLVING DIFFICULT 4705 03:07:48,426 --> 03:07:48,893 PROBLEMS. 4706 03:07:48,893 --> 03:07:50,361 WE WANT TO CONVENE WORKSHOPS AND 4707 03:07:50,361 --> 03:07:52,496 OTHER MEETINGS WITH THE SPECIFIC 4708 03:07:52,496 --> 03:07:53,698 GOALS OF ENGAGING RESEARCH 4709 03:07:53,698 --> 03:07:55,499 COMMUNITY TO DISCUSS THE STATE 4710 03:07:55,499 --> 03:07:57,902 OF SCIENCE, USE THESE AS 4711 03:07:57,902 --> 03:07:59,870 PLATFORMS FOR EDUCATION AND 4712 03:07:59,870 --> 03:08:01,806 OUTREACH, TO INCREASE AWARENESS 4713 03:08:01,806 --> 03:08:04,809 OF THE NEURAL EXPOSOME, SO WE 4714 03:08:04,809 --> 03:08:06,477 HOPE TO BRING TOGETHER POTENTIAL 4715 03:08:06,477 --> 03:08:07,712 COLLABORATORS TO BUILD THAT 4716 03:08:07,712 --> 03:08:09,647 COMMUNITY THAT WE'VE BEEN 4717 03:08:09,647 --> 03:08:09,947 DISCUSSING. 4718 03:08:09,947 --> 03:08:11,749 I'M EXCITED TO ANNOUNCE WE HAVE 4719 03:08:11,749 --> 03:08:15,753 OUR FIRST WORKSHOP PLANNED FOR 4720 03:08:15,753 --> 03:08:16,854 JANUARY 2026, LOOKING AT 4721 03:08:16,854 --> 03:08:19,991 INTERACTION OF MULTIPLE EXPOSOME 4722 03:08:19,991 --> 03:08:21,125 FACTORS AND CUMULATIVE EFFECT 4723 03:08:21,125 --> 03:08:22,927 ACROSS THE LIFE COURSE. 4724 03:08:22,927 --> 03:08:24,228 WE'RE ALSO LOOKING AT FACTORS 4725 03:08:24,228 --> 03:08:26,964 THAT DEGRADE OR BOOST 4726 03:08:26,964 --> 03:08:28,833 NEUROLOGICAL RESILIENCE WITH AN 4727 03:08:28,833 --> 03:08:30,234 EYE ON VULNERABLE LIFE STAGES 4728 03:08:30,234 --> 03:08:32,036 AND CRITICAL WINDOWS OF 4729 03:08:32,036 --> 03:08:32,570 EXPOSURE. 4730 03:08:32,570 --> 03:08:35,706 RIGHT KNOW THIS IS PLANNED AS A 4731 03:08:35,706 --> 03:08:36,574 TWO-DAY IN-PERSON WORKSHOP AT 4732 03:08:36,574 --> 03:08:38,342 THE NEURAL SCIENCE CENTER IN 4733 03:08:38,342 --> 03:08:41,746 BETHESDA, MARYLAND, SO BE ON THE 4734 03:08:41,746 --> 03:08:43,814 LOOKOUT FOR MORE INFORMATION, 4735 03:08:43,814 --> 03:08:44,148 REGISTRATION. 4736 03:08:44,148 --> 03:08:45,783 OUR OFFICE HAS COLLABORATED ON 4737 03:08:45,783 --> 03:08:48,185 OTHER STRATEGIC PLANNING EFFORTS 4738 03:08:48,185 --> 03:08:50,554 TO INTEGRATE SYMPOSIA ON 4739 03:08:50,554 --> 03:08:51,922 EXPOSOME FACTORS SUCH AS 4740 03:08:51,922 --> 03:08:53,657 ALZHEIMER'S DISEASE AND RELATED 4741 03:08:53,657 --> 03:08:56,260 DEMENTIA SUMMIT COMING UP IN A 4742 03:08:56,260 --> 03:08:58,195 FEW WEEKS THIS JUNE. 4743 03:08:58,195 --> 03:09:00,898 WE ALSO RECENTLY LAUNCHED A NEW 4744 03:09:00,898 --> 03:09:03,300 NIH BRAIN AND BODY EXPOSOME 4745 03:09:03,300 --> 03:09:05,369 SEMINAR SERIES THAT HAS BEEN 4746 03:09:05,369 --> 03:09:06,937 WELL RECEIVED, HERE WE'RE 4747 03:09:06,937 --> 03:09:10,074 EXPLORING HOW THE EXPOSOME 4748 03:09:10,074 --> 03:09:10,941 INFLUENCES BIDIRECTIONAL 4749 03:09:10,941 --> 03:09:12,209 COMMUNICATION BETWEEN CENTRAL 4750 03:09:12,209 --> 03:09:14,345 NERVOUS SYSTEM AND OTHER ORGAN 4751 03:09:14,345 --> 03:09:16,547 SYSTEMS IN THE BODY AND HOW THAT 4752 03:09:16,547 --> 03:09:21,585 IMPACTS BRAIN HEALTH AND ZEALS.- 4753 03:09:21,585 --> 03:09:21,819 DISEASE. 4754 03:09:21,819 --> 03:09:23,954 WE'RE PLANNING A WORKSHOP ON 4755 03:09:23,954 --> 03:09:24,789 TOOLS AND METHODOLOGY ASSESSING 4756 03:09:24,789 --> 03:09:27,792 NEEDS FOR COMMUNITIES AS WELL AS 4757 03:09:27,792 --> 03:09:32,096 MODEL BEST PRACTICES FOR NEURAL 4758 03:09:32,096 --> 03:09:37,134 EXPOSOME SCIENCE. 4759 03:09:37,134 --> 03:09:37,902 NEXT SLIDE PLEASE. 4760 03:09:37,902 --> 03:09:41,072 SO LAST BUT NOT LEAST FOCUS 4761 03:09:41,072 --> 03:09:44,108 AREAS WE WANT TO SUPPORT NEURAL 4762 03:09:44,108 --> 03:09:45,209 EXPOSOME RESEARCH. 4763 03:09:45,209 --> 03:09:48,312 SO RESEARCH THAT GETS TO 4764 03:09:48,312 --> 03:09:49,547 IDENTIFYING IMPORTANT EXPOSOME 4765 03:09:49,547 --> 03:09:51,715 FACTORS THAT ALTER BRAIN HEALTH, 4766 03:09:51,715 --> 03:09:53,818 AS WELL AS SHIFTING TO A 4767 03:09:53,818 --> 03:09:55,453 HOLISTIC APPROACH WHERE WE 4768 03:09:55,453 --> 03:09:58,055 EXPAND OUR VIEWS AND ARE NO 4769 03:09:58,055 --> 03:10:00,724 LONGER LOOKING TO SPOTLIGHT ONE 4770 03:10:00,724 --> 03:10:03,561 FACTOR BUT WORKING TO UNDERSTAND 4771 03:10:03,561 --> 03:10:05,429 AND STUDY ASSOCIATIONS BETWEEN 4772 03:10:05,429 --> 03:10:07,298 MULTIPLE EXPOSOME FACTORS AND 4773 03:10:07,298 --> 03:10:08,632 THEIR IMPACT ON NEUROLOGICAL 4774 03:10:08,632 --> 03:10:09,733 DISEASE. 4775 03:10:09,733 --> 03:10:12,203 WE NEED TO UNDERSTAND THE 4776 03:10:12,203 --> 03:10:14,738 UNDERLYING MECHANISMS THROUGH 4777 03:10:14,738 --> 03:10:16,207 WHICH EXPOSOME FACTORS ACT. 4778 03:10:16,207 --> 03:10:19,210 WITH THAT WE CAN IDENTIFY NEW 4779 03:10:19,210 --> 03:10:20,444 DRUGGABLE TARGETS TO MODULATE 4780 03:10:20,444 --> 03:10:21,946 DISEASE OUTCOMES. 4781 03:10:21,946 --> 03:10:24,181 WE NEED TO ENGAGE THE COMMUNITY, 4782 03:10:24,181 --> 03:10:26,550 AND STUDY THESE EXPOSOME FACTORS 4783 03:10:26,550 --> 03:10:27,284 IN REPRESENTATIVE COHORTS AND 4784 03:10:27,284 --> 03:10:30,387 MAKE SURE WE'RE DOING IT ACROSS 4785 03:10:30,387 --> 03:10:32,223 THE LIFE COURSE. 4786 03:10:32,223 --> 03:10:34,992 SO ONLY WITH COHORTS THAT ARE 4787 03:10:34,992 --> 03:10:36,093 REPRESENTATIVE OF THE HUMAN 4788 03:10:36,093 --> 03:10:37,928 POPULATIONS CAN WE UNDERSTAND 4789 03:10:37,928 --> 03:10:41,265 INTERPLAY OF MODIFIABLE EXPOSOME 4790 03:10:41,265 --> 03:10:43,000 FACTORS LIKE STRESS, DIET, 4791 03:10:43,000 --> 03:10:45,836 EXERCISE, WITH THE 4792 03:10:45,836 --> 03:10:47,204 NON-MODIFIABLE FACTORS LIKE AGE, 4793 03:10:47,204 --> 03:10:48,672 SEX, GENETICS, AND START TO 4794 03:10:48,672 --> 03:10:50,174 ANSWER QUESTIONS ABOUT WHY 4795 03:10:50,174 --> 03:10:52,209 DIFFERENT PEOPLE WITH THE SAME 4796 03:10:52,209 --> 03:10:55,880 EXPOSURES HAVE DIFFERENT DISEASE 4797 03:10:55,880 --> 03:10:56,147 OUTCOMES. 4798 03:10:56,147 --> 03:11:00,184 CLICK ONCE FOR ME. 4799 03:11:00,184 --> 03:11:01,352 THANK YOU. 4800 03:11:01,352 --> 03:11:04,188 AND SO LONG-TERM GOALS, REALLY 4801 03:11:04,188 --> 03:11:08,225 WITH ENOUGH DATA TO DEVELOP A 4802 03:11:08,225 --> 03:11:10,060 NEURAL EXPOSOME FRAMEWORK TO 4803 03:11:10,060 --> 03:11:10,661 PREDICT NEUROLOGICAL DISEASE 4804 03:11:10,661 --> 03:11:14,765 RISK BASED ON THE TOTALITY OF AN 4805 03:11:14,765 --> 03:11:15,266 INDIVIDUAL'S EXPOSOME. 4806 03:11:15,266 --> 03:11:19,603 SO WE CAN USE THIS TO PREVENT 4807 03:11:19,603 --> 03:11:21,739 DISEASE, MODIFY DISEASE 4808 03:11:21,739 --> 03:11:24,341 PROGRESSION, AND WHEN NEEDED 4809 03:11:24,341 --> 03:11:25,276 ADMINISTER PERSONALIZED 4810 03:11:25,276 --> 03:11:30,247 PRECISION THERAPEUTIC REGIMES 4811 03:11:30,247 --> 03:11:31,482 FOR IMPROVED OUTCOMES. 4812 03:11:31,482 --> 03:11:31,949 OKAY. 4813 03:11:31,949 --> 03:11:33,784 SO WE WALKED YOU THROUGH THE 4814 03:11:33,784 --> 03:11:36,187 FIVE AREAS OF FOCUS FOR OUR 4815 03:11:36,187 --> 03:11:37,388 RECOMMENDED IMPLEMENTATION 4816 03:11:37,388 --> 03:11:37,721 ACTIVITIES. 4817 03:11:37,721 --> 03:11:39,390 AND THIS SLIDE IS A BIG PICTURE 4818 03:11:39,390 --> 03:11:41,325 OF WHAT WE'RE TRYING TO 4819 03:11:41,325 --> 03:11:43,093 ACCOMPLISH OVER THE NEXT SEVERAL 4820 03:11:43,093 --> 03:11:43,327 YEARS. 4821 03:11:43,327 --> 03:11:47,798 AND WE HOPE YOU HAVE SEEN AN 4822 03:11:47,798 --> 03:11:49,433 OVERARCHING THEME OF 4823 03:11:49,433 --> 03:11:50,234 COLLABORATION, COMMUNICATION, 4824 03:11:50,234 --> 03:11:50,768 AND LEVERAGING. 4825 03:11:50,768 --> 03:11:53,571 SO WE WANT TO BUILD ON WHAT 4826 03:11:53,571 --> 03:11:56,574 OTHERS HAVE DONE, BREAK DOWN 4827 03:11:56,574 --> 03:11:58,576 SILOS AND ADJACENT DISCIPLINES, 4828 03:11:58,576 --> 03:12:00,811 AND ACCELERATE BREAKTHROUGHS IN 4829 03:12:00,811 --> 03:12:01,946 NEURAL EXPOSOME RESEARCH. 4830 03:12:01,946 --> 03:12:05,182 VERY BRIEFLY, WE WANT TO FOCUS 4831 03:12:05,182 --> 03:12:06,917 ON AND BUILD PARTNERSHIPS, 4832 03:12:06,917 --> 03:12:08,719 AMPLIFY AND MAKE SURE EVERYONE 4833 03:12:08,719 --> 03:12:12,189 KNOWS WE'RE INVESTED IN NEURAL 4834 03:12:12,189 --> 03:12:14,959 EXPOSOME RESEARCH, START TO TAP 4835 03:12:14,959 --> 03:12:15,793 INTO EXISTING RESOURCES AND 4836 03:12:15,793 --> 03:12:17,027 TOOLS TO FIGURE OUT WHAT'S 4837 03:12:17,027 --> 03:12:18,629 MISSING AND WHAT WE NEED TO DO 4838 03:12:18,629 --> 03:12:19,029 NEXT. 4839 03:12:19,029 --> 03:12:21,999 WE WANT TO HAVE SOME INTERESTING 4840 03:12:21,999 --> 03:12:23,167 WORKSHOPS, AND YOU'RE ALL 4841 03:12:23,167 --> 03:12:23,667 INVITED TO ATTEND. 4842 03:12:23,667 --> 03:12:28,205 WE WANT TO USE THESE AS 4843 03:12:28,205 --> 03:12:32,209 PLATFORMS FOR DISCUSSING STATE 4844 03:12:32,209 --> 03:12:37,114 OF SCIENCE, EDUCATION, OUTREACH, 4845 03:12:37,114 --> 03:12:40,217 FACILITATE TRAINING, INCREASE 4846 03:12:40,217 --> 03:12:48,525 NUMBER OF INVESTIGATORS AND 4847 03:12:48,525 --> 03:12:50,227 BUILD DISCIPLINARY TEAMS AND 4848 03:12:50,227 --> 03:12:52,162 LASTLY FOCUS ON NEURAL EXPOSOME 4849 03:12:52,162 --> 03:12:53,964 RESEARCH IN THESE AREAS THAT WE 4850 03:12:53,964 --> 03:12:59,603 ELABORATED ON IN THE PREVIOUS 4851 03:12:59,603 --> 03:13:00,771 SLIDE. 4852 03:13:00,771 --> 03:13:01,739 DR. JETT SHOWED YOU WE'RE 4853 03:13:01,739 --> 03:13:03,307 SPENDING VERY LITTLE OF OUR 4854 03:13:03,307 --> 03:13:05,909 MONEY ON WHAT COULD PREVENT THE 4855 03:13:05,909 --> 03:13:09,213 MAJORITY OF DISEASE. 4856 03:13:09,213 --> 03:13:10,047 UNDERSTANDING THE NEURAL 4857 03:13:10,047 --> 03:13:11,515 EXPOSOME IS THE MOST PROMISING 4858 03:13:11,515 --> 03:13:13,050 OPTION TO INCREASE HEALTH SPAN, 4859 03:13:13,050 --> 03:13:14,752 THAT'S A NUMBER OF HEALTHY YEARS 4860 03:13:14,752 --> 03:13:18,489 WE HAVE IN THIS LIFE AND PREVENT 4861 03:13:18,489 --> 03:13:22,626 CHRONIC AND LONG-LASTING 4862 03:13:22,626 --> 03:13:24,461 DISEASES LIKE ALZHEIMER'S, 4863 03:13:24,461 --> 03:13:25,095 DEMENTIA, STROKE, PARKINSON'S, 4864 03:13:25,095 --> 03:13:28,198 AND ALSO TRY TO GET AT SOME ROOT 4865 03:13:28,198 --> 03:13:33,203 CAUSES OF MANY NEUROLOGICAL 4866 03:13:33,203 --> 03:13:34,004 DISORDERS LIKE NEUROINFLAMMATION 4867 03:13:34,004 --> 03:13:35,606 SO IN STUDYING THE EXPOSOME IT 4868 03:13:35,606 --> 03:13:37,841 GETS US THAT MUCH CLOSER TO THE 4869 03:13:37,841 --> 03:13:39,209 MISSION REDUCING BURDEN OF 4870 03:13:39,209 --> 03:13:42,813 NEUROLOGICAL DISEASES FOR ALL 4871 03:13:42,813 --> 03:13:44,048 PEOPLE. 4872 03:13:44,048 --> 03:13:45,349 SO AS YOU CAN IMAGINE, THERE 4873 03:13:45,349 --> 03:13:46,684 WERE MANY CONTRIBUTORS TO THIS 4874 03:13:46,684 --> 03:13:48,786 WORK, AND WE WOULD LIKE TO THANK 4875 03:13:48,786 --> 03:13:50,921 THEM ALL STARTING WITH THE 4876 03:13:50,921 --> 03:13:53,390 WORKINGS OF COUNCIL THAT GAVE US 4877 03:13:53,390 --> 03:13:54,925 THE REPORT AND SIX PRIORITIES, 4878 03:13:54,925 --> 03:13:59,797 OFFICE OF NEURAL EXPOSOME AND 4879 03:13:59,797 --> 03:14:00,531 TOXICOLOGY, NIH ENVIRONMENTAL 4880 03:14:00,531 --> 03:14:02,232 NEUROSCIENCE WORKING GROUP, AS 4881 03:14:02,232 --> 03:14:03,801 WELL AS NEURAL EXPOSOME 4882 03:14:03,801 --> 03:14:05,302 IMPLEMENTATION WORKING GROUP, 4883 03:14:05,302 --> 03:14:07,471 AND OTHERS THAT HAVE PROVIDED 4884 03:14:07,471 --> 03:14:10,107 INVALUABLE FEEDBACK AND INPUT ON 4885 03:14:10,107 --> 03:14:11,575 IMPLEMENTATION PLANS. 4886 03:14:11,575 --> 03:14:13,577 OUR COLLEAGUES SHOWN WITH AN 4887 03:14:13,577 --> 03:14:15,546 ASTERISK ARE NO LONGER AT NIH 4888 03:14:15,546 --> 03:14:17,481 DUE TO COMBINATION OF 4889 03:14:17,481 --> 03:14:18,716 RETIREMENTS AND REDUCTIONS IN 4890 03:14:18,716 --> 03:14:18,916 FORCE. 4891 03:14:18,916 --> 03:14:24,221 BUT WE DO WANT TO RECOGNIZE 4892 03:14:24,221 --> 03:14:25,089 THEIR EFFORTS TOWARD OUR 4893 03:14:25,089 --> 03:14:25,789 IMPLEMENTATION PLAN. 4894 03:14:25,789 --> 03:14:32,896 WITH THAT WE'D LIKE TO GO BACK 4895 03:14:32,896 --> 03:14:34,298 TO THE PREVIOUS SLIDE, AND WE'LL 4896 03:14:34,298 --> 03:14:37,034 TAKE ANY QUESTIONS THAT YOU 4897 03:14:37,034 --> 03:14:43,240 HAVE. 4898 03:14:43,240 --> 03:14:46,944 >> IF I COULD JUST WEIGH IN 4899 03:14:46,944 --> 03:14:49,613 QUICKLY, THAT WAS AN EXCELLENT 4900 03:14:49,613 --> 03:14:50,247 PRESENTATION ILLUSTRATING THE 4901 03:14:50,247 --> 03:14:52,616 COLLABORATIVE EFFORTS ACROSS THE 4902 03:14:52,616 --> 03:14:52,916 NIH. 4903 03:14:52,916 --> 03:14:55,085 AND IT'S -- I SHOULD HAVE MADE 4904 03:14:55,085 --> 03:14:55,986 IT CLEARER IN MY PRESENTATION 4905 03:14:55,986 --> 03:14:56,820 WE'RE NOT DOING IT ALL. 4906 03:14:56,820 --> 03:14:59,823 I THINK THIS IS A GREAT EXAMPLE 4907 03:14:59,823 --> 03:15:02,726 OF HOW NIEHS CAN TAKE THE LEAD 4908 03:15:02,726 --> 03:15:05,629 ON DEFINING ASPECTS OF THE 4909 03:15:05,629 --> 03:15:07,765 EXPOSOME BUT THEN HAVING ALL OF 4910 03:15:07,765 --> 03:15:09,433 YOU AT NINDS REALLY EMBRACING 4911 03:15:09,433 --> 03:15:11,235 SOME OF THESE CONCEPTS AND THEN 4912 03:15:11,235 --> 03:15:13,070 PUTTING IN PRACTICE FOR THE 4913 03:15:13,070 --> 03:15:16,740 BENEFIT OF BETTER UNDERSTANDING 4914 03:15:16,740 --> 03:15:18,609 THE DARK MATTER OF NEUROLOGICAL 4915 03:15:18,609 --> 03:15:19,943 DISEASE, THIS IS GREAT. 4916 03:15:19,943 --> 03:15:21,078 CONGRATULATIONS, THAT'S 4917 03:15:21,078 --> 03:15:21,378 TERRIFIC. 4918 03:15:21,378 --> 03:15:26,984 VERY SUPPORTIVE OF WHAT IT IS 4919 03:15:26,984 --> 03:15:30,120 THAT YOU'RE DESCRIBING HERE. 4920 03:15:30,120 --> 03:15:31,121 >> REALLY APPRECIATE THAT 4921 03:15:31,121 --> 03:15:31,622 ENDORSEMENT AND COMMENT. 4922 03:15:31,622 --> 03:15:36,427 THANK YOU SO MUCH FOR THAT. 4923 03:15:36,427 --> 03:15:38,228 >> QUESTIONS? 4924 03:15:38,228 --> 03:15:45,102 THERE'S A QUESTION ONLINE. 4925 03:15:45,102 --> 03:15:45,569 STEWART, IS THAT YOU? 4926 03:15:45,569 --> 03:15:46,503 >> YEAH. 4927 03:15:46,503 --> 03:15:48,772 I THOUGHT YOU WERE GOING TO TAKE 4928 03:15:48,772 --> 03:15:50,507 ONE THAT WAS IN THE CHAT. 4929 03:15:50,507 --> 03:15:52,209 >> NO, SORRY. 4930 03:15:52,209 --> 03:15:54,845 >> THAT'S OKAY. 4931 03:15:54,845 --> 03:16:00,184 THANK YOU FOR THAT GREAT 4932 03:16:00,184 --> 03:16:02,386 THREE-PERSON PRESENTATION. 4933 03:16:02,386 --> 03:16:05,355 FROM THE DEPARTMENT OF VETERANS 4934 03:16:05,355 --> 03:16:10,394 AFFAIRS, BEING IN THE V.A., WE 4935 03:16:10,394 --> 03:16:12,996 HAVE TOXIC EXPOSURE RISK, BUT MY 4936 03:16:12,996 --> 03:16:18,735 AREA IS TRAUMATIC BRAIN INJURY. 4937 03:16:18,735 --> 03:16:20,971 AND THERE ARE SEVERAL 4938 03:16:20,971 --> 03:16:21,805 NINDS-FUNDED INVESTIGATORS LIKE 4939 03:16:21,805 --> 03:16:24,541 DOUG SMITH, HE HAS WORKED WITH 4940 03:16:24,541 --> 03:16:25,943 INTERNATIONAL COLLABORATORS, AND 4941 03:16:25,943 --> 03:16:28,078 THEY HAVE SHOWN THE BLOOD-BRAIN 4942 03:16:28,078 --> 03:16:30,481 BARRIER IS DISRUPTED FOR MANY 4943 03:16:30,481 --> 03:16:33,517 YEARS AFTER A BRAIN INJURY. 4944 03:16:33,517 --> 03:16:35,486 THAT'S NOT EVEN LIKE A SEVERE 4945 03:16:35,486 --> 03:16:42,326 ONE, COULD BE EVEN MINOR. 4946 03:16:42,326 --> 03:16:44,194 SO CONSIDERING LIKE 4947 03:16:44,194 --> 03:16:46,530 SPORTS-RELATED BRAIN INJURY, 4948 03:16:46,530 --> 03:16:47,931 INTIMATE PARTNER VIOLENCE, AND 4949 03:16:47,931 --> 03:16:51,368 WHAT HAPPENS WITH OUR VETERANS, 4950 03:16:51,368 --> 03:16:56,073 BOTH WITH TBI AND MILITARY 4951 03:16:56,073 --> 03:16:57,007 OCCUPATION BLAST EXPOSURE ARE 4952 03:16:57,007 --> 03:16:57,641 YOU CONSIDERING PHYSICAL 4953 03:16:57,641 --> 03:17:01,678 ACTIVITY TO THE BRAIN TISSUE 4954 03:17:01,678 --> 03:17:11,054 THAT COULD DISRUPT THE 4955 03:17:11,054 --> 03:17:11,688 METABOLISM AND BLOOD-BRAIN 4956 03:17:11,688 --> 03:17:12,789 BARRIER FOR YEARS AS ONE OF THE 4957 03:17:12,789 --> 03:17:14,758 ELEPHANTS IN THE ROOM THAT NEEDS 4958 03:17:14,758 --> 03:17:17,828 TO BE LOOKED AT? 4959 03:17:17,828 --> 03:17:18,028 OVER. 4960 03:17:18,028 --> 03:17:20,097 >> I WOULD SAY YES. 4961 03:17:20,097 --> 03:17:22,533 I MEAN, JUST AS WALTER SAID, 4962 03:17:22,533 --> 03:17:24,067 ANYTHING THAT'S NOT GENETICS, I 4963 03:17:24,067 --> 03:17:25,369 THINK DR. WOYCHIK SAID THE SAME 4964 03:17:25,369 --> 03:17:27,738 THING, WE REALLY HAVE TO 4965 03:17:27,738 --> 03:17:29,072 CONSIDER ALL OF THESE THINGS 4966 03:17:29,072 --> 03:17:31,375 THAT MAYBE HAVE NOT BEEN 4967 03:17:31,375 --> 03:17:33,911 PREVIOUSLY LOOKED AT BEFORE, AND 4968 03:17:33,911 --> 03:17:35,112 I THINK THAT'S DEFINITELY ON THE 4969 03:17:35,112 --> 03:17:36,179 LIST. 4970 03:17:36,179 --> 03:17:38,048 >> I THOUGHT YOU WERE GOING 4971 03:17:38,048 --> 03:17:44,021 TOWARDS OTHER THINGS BESIDES 4972 03:17:44,021 --> 03:17:44,221 THAT. 4973 03:17:44,221 --> 03:17:46,356 THAT COULD ACTUALLY CAUSE -- 4974 03:17:46,356 --> 03:17:49,660 >> WELL, YOU CAN GO UP IN 4975 03:17:49,660 --> 03:17:58,902 DIRECTIONS LIKE INFECTION, VIRAL 4976 03:17:58,902 --> 03:17:59,169 INFECTIONS 4977 03:17:59,169 --> 03:17:59,436 >> RIGHT. 4978 03:17:59,436 --> 03:18:03,073 >> MY COUNTERPART HERE IN THE 4979 03:18:03,073 --> 03:18:05,876 TOXIC EXPOSURE RESEARCH PROGRAM 4980 03:18:05,876 --> 03:18:08,211 DO WE MAKE A CROSS-INTERSECTING 4981 03:18:08,211 --> 03:18:11,148 ANNOUNCEMENT LOOKING AT WHETHER 4982 03:18:11,148 --> 03:18:12,883 THESE TYPES OF BRAIN INJURIES 4983 03:18:12,883 --> 03:18:13,884 INCREASE THE PENETRATION INTO 4984 03:18:13,884 --> 03:18:18,689 THE BRAIN OF VARIOUS TOXINS. 4985 03:18:18,689 --> 03:18:21,058 SO, THAT'S -- THAT WOULD BE 4986 03:18:21,058 --> 03:18:26,229 MAYBE SOMETHING FUTURE BETWEEN 4987 03:18:26,229 --> 03:18:27,698 THE AGENCIES. 4988 03:18:27,698 --> 03:18:28,465 >> YEAH, IT'S HARD TO SAY THAT'S 4989 03:18:28,465 --> 03:18:32,235 NOT PART OF THE EXPOSOME. 4990 03:18:32,235 --> 03:18:33,870 IT'S ALMOST EVERYTHING. 4991 03:18:33,870 --> 03:18:35,138 BUT THAT'S A WHOLE OTHER STORY. 4992 03:18:35,138 --> 03:18:37,941 >> IF I COULD CHIME IN, STUART, 4993 03:18:37,941 --> 03:18:39,843 THAT'S ABSOLUTELY PART OF THE 4994 03:18:39,843 --> 03:18:40,110 EXPOSOME. 4995 03:18:40,110 --> 03:18:41,979 AND THE THING I WANT TO 4996 03:18:41,979 --> 03:18:44,214 EMPHASIZE, YOU ALLUDED TO THIS, 4997 03:18:44,214 --> 03:18:45,849 THERE MAY BE SYNERGISTIC 4998 03:18:45,849 --> 03:18:47,684 EFFECTS, THERE MAY BE CHEMICAL 4999 03:18:47,684 --> 03:18:50,220 EXPOSURES, AND THAT IF YOU NOW 5000 03:18:50,220 --> 03:18:53,156 HAVE THE BRAIN INJURY, THAT MAY 5001 03:18:53,156 --> 03:18:55,592 BE WORKING SYNERGISTICALLY WITH 5002 03:18:55,592 --> 03:18:56,259 CHEMICAL EXPOSURES EXACERBATING 5003 03:18:56,259 --> 03:18:57,728 EFFECT OF CHEMICAL EXPOSURES. 5004 03:18:57,728 --> 03:19:00,497 THAT'S THE CHALLENGE WITH THESE 5005 03:19:00,497 --> 03:19:02,432 EXPOSOME FRAMEWORKS, HOW DO WE 5006 03:19:02,432 --> 03:19:04,301 MEASURE THIS? 5007 03:19:04,301 --> 03:19:07,204 IT MIGHT BE, YOU KNOW, MOVING 5008 03:19:07,204 --> 03:19:08,171 INTO SOME VERY INNOVATIVE 5009 03:19:08,171 --> 03:19:08,438 THINKING. 5010 03:19:08,438 --> 03:19:09,773 I MEAN, WE'RE DOING WHAT WE CAN 5011 03:19:09,773 --> 03:19:11,642 DO NOW, WHICH IS IMPORTANT. 5012 03:19:11,642 --> 03:19:12,776 JUST LIKE THE GENOME PROJECT, WE 5013 03:19:12,776 --> 03:19:17,014 USED SOME OF THE EXISTING 5014 03:19:17,014 --> 03:19:18,982 TECHNOLOGIES TO GET MOVING, HIGH 5015 03:19:18,982 --> 03:19:20,050 RESOLUTION MASS SPEC, MANY 5016 03:19:20,050 --> 03:19:21,385 THINGS WE HEARD ABOUT, BUT THERE 5017 03:19:21,385 --> 03:19:24,688 MAY BE SOME OTHER INNOVATIVE 5018 03:19:24,688 --> 03:19:25,922 THINGS THAT IT'S A BETTER 5019 03:19:25,922 --> 03:19:27,724 APPROACH TO LOOK AT THOSE 5020 03:19:27,724 --> 03:19:29,493 SYNERGISTIC EFFECTS OVER THE 5021 03:19:29,493 --> 03:19:29,793 LIFE COURSE. 5022 03:19:29,793 --> 03:19:32,429 SO, THESE ARE THINGS THAT ARE 5023 03:19:32,429 --> 03:19:34,598 EVOLVING, STICK WITH THIS, BUT 5024 03:19:34,598 --> 03:19:36,233 YOUR COLLEAGUES AT NINDS ARE 5025 03:19:36,233 --> 03:19:39,136 RIGHT ON TOP OF IT. 5026 03:19:39,136 --> 03:19:41,038 AND I KNOW THAT IT'S BEEN A 5027 03:19:41,038 --> 03:19:43,273 PLEASURE WORKING WITH THEM BUT 5028 03:19:43,273 --> 03:19:44,207 YOU'RE ABSOLUTELY CORRECT. 5029 03:19:44,207 --> 03:19:45,976 TRAUMATIC BRAIN INJURY IS 5030 03:19:45,976 --> 03:19:48,245 CRITICALLY IMPORTANT PART OF THE 5031 03:19:48,245 --> 03:19:48,578 EXPOSOME. 5032 03:19:48,578 --> 03:19:50,447 >> IF I COULD CHIME IN ON WHAT 5033 03:19:50,447 --> 03:19:52,983 RICK JUST SAID TOO, TALKING 5034 03:19:52,983 --> 03:19:54,251 ABOUT THE SYNERGISTIC EFFECTS, 5035 03:19:54,251 --> 03:19:55,619 THAT'S WHAT'S REALLY DIFFERENT 5036 03:19:55,619 --> 03:19:56,953 ABOUT WHAT WE'RE TRYING TO DO 5037 03:19:56,953 --> 03:19:57,587 HERE. 5038 03:19:57,587 --> 03:20:00,223 THAT'S WHY WE HAVE TO LOOK AT 5039 03:20:00,223 --> 03:20:01,324 MULTIPLE FACTORS, PEOPLE HAVE 5040 03:20:01,324 --> 03:20:03,560 STUDIED SLEEP, MANY OF THESE IN 5041 03:20:03,560 --> 03:20:06,329 ISOLATION FOR A LONG TIME BUT 5042 03:20:06,329 --> 03:20:11,768 WE'RE NOW GOING TO SEE WHAT 5043 03:20:11,768 --> 03:20:12,903 SYNERGISTICALLY ACTING OUTCOMES, 5044 03:20:12,903 --> 03:20:14,304 LOOKING AT MULTIPLE FACTORS AT 5045 03:20:14,304 --> 03:20:16,540 THE SAME TIME, A REALLY 5046 03:20:16,540 --> 03:20:18,508 IMPORTANT NUANCE YOU ADDED 5047 03:20:18,508 --> 03:20:19,443 ONTOTHAT. 5048 03:20:19,443 --> 03:20:20,811 >> I'M NOT A NEUROSCIENTIST, I 5049 03:20:20,811 --> 03:20:22,179 CAN'T SPEAK TO THIS BUT IT COULD 5050 03:20:22,179 --> 03:20:25,115 BE SLEEP IS ANOTHER VERY 5051 03:20:25,115 --> 03:20:25,716 IMPORTANT VARIABLE TO 5052 03:20:25,716 --> 03:20:28,018 POTENTIALLY MITIGATE SOME OF THE 5053 03:20:28,018 --> 03:20:29,986 NEGATIVE EFFECTS OF THE BRAIN 5054 03:20:29,986 --> 03:20:31,221 INJURIES, SO THESE ARE ALL 5055 03:20:31,221 --> 03:20:32,956 THINGS THAT HAVE TO BE FACTORED 5056 03:20:32,956 --> 03:20:36,793 INTO THE EQUATION, THE 5057 03:20:36,793 --> 03:20:38,328 NON-GENETIC CONTRIBUTORS TO 5058 03:20:38,328 --> 03:20:43,066 NEUROLOGICAL DISEASE. 5059 03:20:43,066 --> 03:20:43,300 5060 03:20:43,300 --> 03:20:44,568 >> GRAY HAS A QUESTION. 5061 03:20:44,568 --> 03:20:45,402 >> THAT WAS A WONDERFUL 5062 03:20:45,402 --> 03:20:45,802 PRESENTATION. 5063 03:20:45,802 --> 03:20:47,637 THANK YOU VERY MUCH FOR THAT. 5064 03:20:47,637 --> 03:20:51,308 AND I REALLY APPLAUD THE 5065 03:20:51,308 --> 03:20:52,476 EFFORTS, PARTICULARLY KNOWING 5066 03:20:52,476 --> 03:20:56,246 THAT WE'RE USING SOMEWHERE ON 5067 03:20:56,246 --> 03:20:59,750 THE ORDER OF 3.6 MILLION TONS OF 5068 03:20:59,750 --> 03:21:01,151 PESTICIDES GLOBALLY EVERY YEAR, 5069 03:21:01,151 --> 03:21:02,753 THIS IS A TREMENDOUS LOAD. 5070 03:21:02,753 --> 03:21:04,755 AND SO EXPLORING THAT SPACE IS 5071 03:21:04,755 --> 03:21:07,858 GOING TO BE TRULY IMPORTANT. 5072 03:21:07,858 --> 03:21:11,561 BUT I WONDER ALSO ABOUT THE 5073 03:21:11,561 --> 03:21:13,396 VASTNESS AND COMPLEXITY OF THE 5074 03:21:13,396 --> 03:21:14,898 PROJECT AS STATED. 5075 03:21:14,898 --> 03:21:17,601 AND AS YOU SAID, IT'S 5076 03:21:17,601 --> 03:21:18,068 ENCOMPASSING VIRTUALLY 5077 03:21:18,068 --> 03:21:18,368 EVERYTHING. 5078 03:21:18,368 --> 03:21:19,569 I'D LIKE TO EVEN GO BEYOND THAT 5079 03:21:19,569 --> 03:21:20,604 TO TALK ABOUT THE SYNERGIES THAT 5080 03:21:20,604 --> 03:21:23,373 YOU WERE JUST TALKING ABOUT, 5081 03:21:23,373 --> 03:21:26,643 WHICH ARE INTERESTING AT THE 5082 03:21:26,643 --> 03:21:28,945 LEVEL OF PERHAPS BRAIN INJURY 5083 03:21:28,945 --> 03:21:30,647 AND TOXINS, BUT IT BECOMES 5084 03:21:30,647 --> 03:21:33,717 VASTLY MORE COMPLEX IF YOU START 5085 03:21:33,717 --> 03:21:36,353 THINKING ABOUT GENE-GENE 5086 03:21:36,353 --> 03:21:36,987 INTERACTIONS AND GENE-SYNTHETIC 5087 03:21:36,987 --> 03:21:38,021 INTERACTIONS WITH THE 5088 03:21:38,021 --> 03:21:41,491 ENVIRONMENT AS WELL, SO THE 5089 03:21:41,491 --> 03:21:43,059 COMPLEXITY COMPOUNDS AND 5090 03:21:43,059 --> 03:21:44,227 COMPOUNDS. 5091 03:21:44,227 --> 03:21:45,428 WHEN WE SEQUENCED THE HUMAN 5092 03:21:45,428 --> 03:21:48,799 GENOME WE KNOW THE TASK AT HAND, 5093 03:21:48,799 --> 03:21:53,236 HAD TO GET THE BASE PAIRS BEHID 5094 03:21:53,236 --> 03:21:54,070 UP. 5095 03:21:54,070 --> 03:21:58,275 COULD -- LINED UP. 5096 03:21:58,275 --> 03:22:00,777 COULD THERE BE A MESSAGE ABOUT 5097 03:22:00,777 --> 03:22:02,279 WHAT THE MAGNITUDE ABOUT THE 5098 03:22:02,279 --> 03:22:05,315 COMPLEXITY, WHERE SYNERGIES ARE 5099 03:22:05,315 --> 03:22:07,851 LIKELY TO RESIDE AND HOW THE 5100 03:22:07,851 --> 03:22:09,186 PLAN TO MOVE FORWARD MIGHT DEAL 5101 03:22:09,186 --> 03:22:11,321 WITH THAT ISSUE WHICH I THINK IS 5102 03:22:11,321 --> 03:22:16,293 THE REALLY REMARKABLE THING THAT 5103 03:22:16,293 --> 03:22:17,761 YOU'RE TRYING TO UNDERTAKE. 5104 03:22:17,761 --> 03:22:18,495 >> YEAH, I DON'T KNOW, RICK, IF 5105 03:22:18,495 --> 03:22:19,729 YOU WANT TO SAY ANYTHING. 5106 03:22:19,729 --> 03:22:24,501 THE THING I THINK ABOUT FIRST IS 5107 03:22:24,501 --> 03:22:26,536 IN 2005, WHEN THIS FIRST CAME 5108 03:22:26,536 --> 03:22:28,004 OUT, EVERYBODY WAS SAYING NO 5109 03:22:28,004 --> 03:22:28,205 WAY. 5110 03:22:28,205 --> 03:22:29,739 THERE'S NO WAY WE CAN DO THIS. 5111 03:22:29,739 --> 03:22:30,740 IT'S NEVER GOING TO HAPPEN. 5112 03:22:30,740 --> 03:22:33,210 NEVER GOING TO HAPPEN. 5113 03:22:33,210 --> 03:22:38,849 BUT THEN I THINK AS TIME GOES 5114 03:22:38,849 --> 03:22:40,083 BY, AND PEOPLE STARTED TO 5115 03:22:40,083 --> 03:22:42,819 UNDERSTAND THAT WE'VE GOT TO DO 5116 03:22:42,819 --> 03:22:43,987 SOMETHING WITH THIS BECAUSE 5117 03:22:43,987 --> 03:22:46,156 WE'VE GOT TO DO THIS, THAT'S ONE 5118 03:22:46,156 --> 03:22:47,657 THING THAT STARTED OFF. 5119 03:22:47,657 --> 03:22:49,826 BUT THEN WE STARTED GETTING NEW 5120 03:22:49,826 --> 03:22:55,265 THINGS COMING IN THAT COULD, YOU 5121 03:22:55,265 --> 03:22:56,800 KNOW, HELP, A.I., MACHINE 5122 03:22:56,800 --> 03:22:58,435 LEARNING, ALL THESE OTHER THINGS 5123 03:22:58,435 --> 03:23:00,437 THAT, OKAY, MAYBE WE CAN DO 5124 03:23:00,437 --> 03:23:02,138 SOMETHING AND START WITH. 5125 03:23:02,138 --> 03:23:04,641 I THINK ANOTHER THING WITH THAT 5126 03:23:04,641 --> 03:23:07,711 IS YOU HAVE TO START SOMEWHERE. 5127 03:23:07,711 --> 03:23:09,379 SOME PEOPLE WILL SAY, YOU CAN 5128 03:23:09,379 --> 03:23:13,783 START BUT YOU WON'T SEE ANYTHING 5129 03:23:13,783 --> 03:23:15,285 UNTIL 15 YEARS FROM NOW OR 5130 03:23:15,285 --> 03:23:15,552 SOMETHING. 5131 03:23:15,552 --> 03:23:19,422 WELL, CAN YOU DO SOME THINGS NOW 5132 03:23:19,422 --> 03:23:20,924 AS A START. 5133 03:23:20,924 --> 03:23:23,059 SO, YEAH, I MEAN I JUST THINK 5134 03:23:23,059 --> 03:23:26,263 THAT YOU'RE RIGHT ABOUT THAT. 5135 03:23:26,263 --> 03:23:27,397 BUT IT'S ALMOST LIKE IMPOSSIBLE 5136 03:23:27,397 --> 03:23:28,965 BUT YOU GOT TO START SOMEWHERE 5137 03:23:28,965 --> 03:23:30,233 TO MAKE IT NOT IMPOSSIBLE. 5138 03:23:30,233 --> 03:23:33,203 THAT'S THE WAY I LOOK AT IT. 5139 03:23:33,203 --> 03:23:34,871 THE WAY I THING WE SHOULD STILL 5140 03:23:34,871 --> 03:23:36,473 BE DOING IT. 5141 03:23:36,473 --> 03:23:37,774 >> ACTUALLY, DAVID, IF YOU 5142 03:23:37,774 --> 03:23:39,876 WOULDN'T MIND, AND GRAY, I COULD 5143 03:23:39,876 --> 03:23:41,177 CHIME IN HERE. 5144 03:23:41,177 --> 03:23:42,579 GRAY, I ASKED THE SAME QUESTION 5145 03:23:42,579 --> 03:23:44,214 RIGHT AT THE BEGINNING WHEN I 5146 03:23:44,214 --> 03:23:45,649 STARTED HEARING ABOUT THE 5147 03:23:45,649 --> 03:23:45,916 EXPOSOME. 5148 03:23:45,916 --> 03:23:49,019 DAVID IS ALLUDED TO THE FACT. 5149 03:23:49,019 --> 03:23:51,788 WHAT THE MOONSHOT THAT'S 5150 03:23:51,788 --> 03:23:53,990 HAPPENING YESTERDAY, TODAY, 5151 03:23:53,990 --> 03:23:56,226 TOMORROW IS ABOUT IS 5152 03:23:56,226 --> 03:23:57,227 OPERATIONALIZING THE EXPOSOME. 5153 03:23:57,227 --> 03:23:59,796 WHAT DO WE NEED TO COLLECT? 5154 03:23:59,796 --> 03:24:01,965 AND THEN BRINGING IN THE 5155 03:24:01,965 --> 03:24:03,400 COLLECTIVE WISDOM OF PEOPLE 5156 03:24:03,400 --> 03:24:04,601 ACROSS THE NIH AND ACROSS THE 5157 03:24:04,601 --> 03:24:06,436 GLOBAL COMMUNITY THAT ARE 5158 03:24:06,436 --> 03:24:07,304 INVOLVED IN THIS. 5159 03:24:07,304 --> 03:24:11,141 IT'S CLEAR WE HAVE CERTAIN TOOLS 5160 03:24:11,141 --> 03:24:13,076 LIKE HIGH RESOLUTION MASS SPEC, 5161 03:24:13,076 --> 03:24:14,277 GIS COORDINATES FOR ESTIMATING 5162 03:24:14,277 --> 03:24:15,145 EXPOSURES BASED ON WHERE YOU 5163 03:24:15,145 --> 03:24:16,646 LIVE, WHERE YOU WORK, WHERE YOU 5164 03:24:16,646 --> 03:24:19,716 LIVED AND WHERE YOU'VE WORKED. 5165 03:24:19,716 --> 03:24:22,419 HOW DO WE KNIT THIS TOGETHER 5166 03:24:22,419 --> 03:24:23,820 INTO A FRAMEWORK TO KNOW WHAT DO 5167 03:24:23,820 --> 03:24:25,455 WE COLLECT AND WHERE DO WE 5168 03:24:25,455 --> 03:24:27,257 COLLECT THIS INFORMATION SO WE 5169 03:24:27,257 --> 03:24:28,491 CAN, YOU KNOW, SYNTHESIZE THIS 5170 03:24:28,491 --> 03:24:30,427 AND BRING IT TOGETHER. 5171 03:24:30,427 --> 03:24:32,696 YOU CAN'T DO EVERYTHING. 5172 03:24:32,696 --> 03:24:35,265 SO THAT'S WHAT THE COMMUNITY IS 5173 03:24:35,265 --> 03:24:38,568 ENGAGED IN RIGHT NOW. 5174 03:24:38,568 --> 03:24:39,736 I THINK THE PRESENTATIONS YOU'VE 5175 03:24:39,736 --> 03:24:43,006 HEARD ARE THINGS WE CAN DO NOW 5176 03:24:43,006 --> 03:24:45,842 THAT I CAN'T IMAGINE THEY WOULD 5177 03:24:45,842 --> 03:24:51,281 NOT BE INTEGRAL TO PARTS OF THE 5178 03:24:51,281 --> 03:24:51,481 FLOW. 5179 03:24:51,481 --> 03:24:51,781 >> I KNOW. 5180 03:24:51,781 --> 03:24:55,018 >> I GUESS IT WAS A GREAT 5181 03:24:55,018 --> 03:24:55,285 QUESTION. 5182 03:24:55,285 --> 03:24:55,552 >> YEAH. 5183 03:24:55,552 --> 03:24:57,754 >> IT WAS A GOOD QUESTION. 5184 03:24:57,754 --> 03:24:59,522 AGAIN, THE WHOLE ISSUE IS STAY 5185 03:24:59,522 --> 03:24:59,723 TUNED. 5186 03:24:59,723 --> 03:25:06,129 AND WE'RE HOPING THAT WE'LL HAVE 5187 03:25:06,129 --> 03:25:07,130 MORE DEFINITION, WHAT DO WE 5188 03:25:07,130 --> 03:25:08,565 COLLECT AND WHAT TIME FRAME AND 5189 03:25:08,565 --> 03:25:11,468 WHAT MAKES THE MOST SENSE TO PUT 5190 03:25:11,468 --> 03:25:14,137 IT TOGETHER AND TO REALLY BRING 5191 03:25:14,137 --> 03:25:16,973 THIS EXPOSOME CONCEPT FORWARD IN 5192 03:25:16,973 --> 03:25:17,841 AN OPERATIONALLY TANGIBLE WAY. 5193 03:25:17,841 --> 03:25:20,543 DOES THAT ANSWER YOUR QUESTION? 5194 03:25:20,543 --> 03:25:22,045 >> IN PART, I GUESS. 5195 03:25:22,045 --> 03:25:23,613 CERTAINLY WITH THE POWERS OF 5196 03:25:23,613 --> 03:25:25,648 A.I. AND THE MANY MODALITIES 5197 03:25:25,648 --> 03:25:27,150 WITH WHICH YOU CAN COLLECT DATA 5198 03:25:27,150 --> 03:25:29,119 ARE HUGE ADVANTAGE RIGHT NOW. 5199 03:25:29,119 --> 03:25:31,421 I WONDER WHETHER THE CONTEXT OF 5200 03:25:31,421 --> 03:25:34,791 NINDS YOU MIGHT BE ABLE TO 5201 03:25:34,791 --> 03:25:37,193 DEFINE A FEW AREAS AND CLASSES 5202 03:25:37,193 --> 03:25:40,730 OF THE EXPOSOME THAT ARE MOST 5203 03:25:40,730 --> 03:25:41,931 LIKELY TO BE RELEVANT TO THE 5204 03:25:41,931 --> 03:25:45,502 TOPICS THAT ARE THE MISSION OF 5205 03:25:45,502 --> 03:25:47,570 NINDS. 5206 03:25:47,570 --> 03:25:48,805 AND WITHIN THAT DEFINED AREA 5207 03:25:48,805 --> 03:25:50,840 EXPLORE WHAT THE TRUE COMPLEXITY 5208 03:25:50,840 --> 03:25:52,242 MIGHT ACTUALLY BE BECAUSE I 5209 03:25:52,242 --> 03:25:54,744 DON'T THINK WE PERHAPS KNOW WHAT 5210 03:25:54,744 --> 03:25:56,579 THE COMPLEXITY IS GOING TO 5211 03:25:56,579 --> 03:25:58,014 EXPOUND TO BECOME. 5212 03:25:58,014 --> 03:26:01,084 BUT IF YOU HAD A FOCUSED 5213 03:26:01,084 --> 03:26:02,752 COMPONENT THAT YOU WERE GOING 5214 03:26:02,752 --> 03:26:05,855 AFTER PERHAPS THAT COMPLEXITY 5215 03:26:05,855 --> 03:26:06,923 COULD BE REVEALED. 5216 03:26:06,923 --> 03:26:07,957 >> I THINK THAT, DAVID, YOU CAN 5217 03:26:07,957 --> 03:26:09,659 SPEAK TO THIS. 5218 03:26:09,659 --> 03:26:12,228 YOU AND YOUR COLLEAGUES AT NINDS 5219 03:26:12,228 --> 03:26:13,797 HAVE PARTICIPATING IN THE 5220 03:26:13,797 --> 03:26:14,798 MOONSHOT, FOR PRECISELY THAT 5221 03:26:14,798 --> 03:26:15,031 REASON. 5222 03:26:15,031 --> 03:26:18,168 WE WANT TO BRING SUBJECT MATTER 5223 03:26:18,168 --> 03:26:18,802 EXPERTS IN DIFFERENT DISEASE 5224 03:26:18,802 --> 03:26:21,204 AREAS FORWARD SO THAT THEY CAN 5225 03:26:21,204 --> 03:26:22,906 BE TEASING OUT SOME OF THE 5226 03:26:22,906 --> 03:26:24,841 VARIABLES AND SOME DETAILS 5227 03:26:24,841 --> 03:26:27,010 AROUND WHAT WOULD YOU COLLECT AS 5228 03:26:27,010 --> 03:26:28,545 RELATES TO NEUROLOGICAL DISEASE. 5229 03:26:28,545 --> 03:26:32,649 SOME OF THE PESTICIDES ARE 5230 03:26:32,649 --> 03:26:34,984 CLEARLY NO BRAINERS. 5231 03:26:34,984 --> 03:26:37,087 YOU KNOW, HOW TO WITHIN THE 5232 03:26:37,087 --> 03:26:41,091 CONTEXT OF PESTICIDES, HOW DO WE 5233 03:26:41,091 --> 03:26:42,292 APPROACH THE EXPOSOME. 5234 03:26:42,292 --> 03:26:44,027 DAVID, DO YOU WANT TO ELABORATE 5235 03:26:44,027 --> 03:26:44,260 ON THIS? 5236 03:26:44,260 --> 03:26:47,197 >> IT BOTHERS ME A LITTLE BIT 5237 03:26:47,197 --> 03:26:50,533 WHEN I THINK ABOUT YOU'RE NOT 5238 03:26:50,533 --> 03:26:52,735 GOING TO GET ANYTHING ANYTIME 5239 03:26:52,735 --> 03:26:54,003 SOON. 5240 03:26:54,003 --> 03:26:56,039 WHEN YOU HAVE PEOPLE THAT ARE 5241 03:26:56,039 --> 03:26:58,441 GETTING SICK, SO I WAS THINKING, 5242 03:26:58,441 --> 03:27:00,543 I THINK THEY SAID THIS, THEY 5243 03:27:00,543 --> 03:27:04,147 SAID THIS TOO I THINK YESTERDAY 5244 03:27:04,147 --> 03:27:08,118 ABOUT JUST DO SOMETHING THAT YOU 5245 03:27:08,118 --> 03:27:09,786 CAN GET A BETTER PLACE FOR 5246 03:27:09,786 --> 03:27:12,088 PEOPLE TO LIVE. 5247 03:27:12,088 --> 03:27:14,657 EVEN IF IT'S NOT EVERYTHING, IF 5248 03:27:14,657 --> 03:27:18,394 YOU CAN GET JUST SOMETHING, THEN 5249 03:27:18,394 --> 03:27:20,230 I THINK -- YOU KNOW, I THINK 5250 03:27:20,230 --> 03:27:21,831 THAT MIGHT BE A GOOD START. 5251 03:27:21,831 --> 03:27:24,200 I DON'T KNOW IF THAT ANSWERS 5252 03:27:24,200 --> 03:27:24,767 YOUR QUESTION. 5253 03:27:24,767 --> 03:27:26,936 >> YEAH, AND I THINK THAT THIS 5254 03:27:26,936 --> 03:27:29,606 IS ALSO PART OF OUR FUTURE 5255 03:27:29,606 --> 03:27:31,508 CONVERSATION, IF WE'RE TALKING 5256 03:27:31,508 --> 03:27:33,676 ABOUT THE TYPES OF -- IF WE DO 5257 03:27:33,676 --> 03:27:35,345 HAVE FUNDING OPPORTUNITIES THAT 5258 03:27:35,345 --> 03:27:38,414 COME OUT, IN THE FUTURE, HOW WE 5259 03:27:38,414 --> 03:27:40,350 WANT TO SHAPE THOSE TO GET THE 5260 03:27:40,350 --> 03:27:41,718 SCIENCE THAT WE WANT TO SEE IN 5261 03:27:41,718 --> 03:27:43,753 THE AREAS WE WANT TO SEE THEM. 5262 03:27:43,753 --> 03:27:45,955 WE WANT TO SEE DIFFERENT THINGS 5263 03:27:45,955 --> 03:27:47,757 ADDRESSED BECAUSE SOME DISEASE 5264 03:27:47,757 --> 03:27:50,727 AREAS ARE A LITTLE BIT FURTHER 5265 03:27:50,727 --> 03:27:52,762 ALONG THAN OTHERS AT STUDYING 5266 03:27:52,762 --> 03:27:54,464 THE EXPOSOME FACTORS, SO THESE 5267 03:27:54,464 --> 03:27:56,132 ARE JUST PARTS OF INITIAL 5268 03:27:56,132 --> 03:27:58,501 CONVERSATIONS THAT WE'RE HAVING 5269 03:27:58,501 --> 03:28:01,504 RIGHT NOW TO DISTINGUISH AREAS 5270 03:28:01,504 --> 03:28:03,072 WOULD BE MORE -- TO SEE WHICH 5271 03:28:03,072 --> 03:28:05,241 AREAS WOULD BE MORE RIPE FOR 5272 03:28:05,241 --> 03:28:05,775 PICKING THAN OTHERS. 5273 03:28:05,775 --> 03:28:08,211 >> YEAH, JUST THE OTHER COMMENT 5274 03:28:08,211 --> 03:28:09,812 I'LL MAKE, I'M OLD NOW HAVE HAVE 5275 03:28:09,812 --> 03:28:13,149 BEEN PART OF THE GENOME, WHERE 5276 03:28:13,149 --> 03:28:13,917 THE MOLECULAR GENETICS COMMUNITY 5277 03:28:13,917 --> 03:28:16,886 PRIOR TO THE GENOME PROJECT, I 5278 03:28:16,886 --> 03:28:18,621 REMEMBER EARLY DISCUSSION ALSO 5279 03:28:18,621 --> 03:28:20,023 WHICH WERE SIMILAR TO SOME OF 5280 03:28:20,023 --> 03:28:21,558 THE COMMENTS YOU'RE MAKING, 5281 03:28:21,558 --> 03:28:25,528 GRAY, ABOUT WHAT ARE WE DOING? 5282 03:28:25,528 --> 03:28:26,996 I MEAN, NUCLEOTIDE SEQUENCE THE 5283 03:28:26,996 --> 03:28:29,399 ENTIRE GENOME? 5284 03:28:29,399 --> 03:28:35,104 THIS IS THE DAYS DOING MAXIMUM 5285 03:28:35,104 --> 03:28:37,907 GILBERT AND THIN GELS, WE HAVE 5286 03:28:37,907 --> 03:28:41,144 TO BE THINKING VERY CREATIVELY 5287 03:28:41,144 --> 03:28:43,646 AND INNOVATIVE WAY, HOW CAN WE 5288 03:28:43,646 --> 03:28:44,714 TACKLE THE PROBLEM? 5289 03:28:44,714 --> 03:28:48,218 IT'S NOT JUST ONE THING IN THE 5290 03:28:48,218 --> 03:28:49,953 ENVIRONMENT THAT'S IMPACTING OUR 5291 03:28:49,953 --> 03:28:50,220 BIOLOGY. 5292 03:28:50,220 --> 03:28:51,621 THERE ARE MULTIPLE DIFFERENT 5293 03:28:51,621 --> 03:28:52,055 THINGS. 5294 03:28:52,055 --> 03:28:54,891 SO ONE THING THAT I'M BRINGING 5295 03:28:54,891 --> 03:29:00,129 TO THE DISCUSSION IS THE ISSUE 5296 03:29:00,129 --> 03:29:01,097 AROUND EPIGENETIC MARKS, YOU 5297 03:29:01,097 --> 03:29:03,766 KNOW, ARE THERE EPIGENETIC MARKS 5298 03:29:03,766 --> 03:29:05,768 IN YOUR GENOME THAT REFLECT 5299 03:29:05,768 --> 03:29:07,303 ENVIRONMENTAL EXPOSURES THAT 5300 03:29:07,303 --> 03:29:09,105 HAPPENED, SAY, DURING PREGNANCY? 5301 03:29:09,105 --> 03:29:12,041 WE STUDY THAT IN MY LAB AND WE 5302 03:29:12,041 --> 03:29:14,444 KNOW THIS. 5303 03:29:14,444 --> 03:29:18,114 TRAITS IN PREGNANCY WITH 5304 03:29:18,114 --> 03:29:18,881 ROTEODONE, TICKLED THE 5305 03:29:18,881 --> 03:29:20,183 MITOCHONDRIA, THERE ARE HUNDREDS 5306 03:29:20,183 --> 03:29:22,685 OF IF NOT THOUSANDS OF DIFFERENT 5307 03:29:22,685 --> 03:29:24,988 EPIGENETIC CHANGES IN THE GENOME 5308 03:29:24,988 --> 03:29:26,522 THAT ARE PERSISTENT THROUGH THE 5309 03:29:26,522 --> 03:29:27,423 LIFE COURSE. 5310 03:29:27,423 --> 03:29:28,858 SO, IT'S ANOTHER WAY OF THINKING 5311 03:29:28,858 --> 03:29:29,959 ABOUT THE EXPOSOME. 5312 03:29:29,959 --> 03:29:31,594 SO THAT'S WHAT WE'RE DOING, 5313 03:29:31,594 --> 03:29:33,663 REALLY TRYING TO BRING THE 5314 03:29:33,663 --> 03:29:35,064 DIFFERENT POINTS OF VIEW 5315 03:29:35,064 --> 03:29:37,066 TOGETHER, AND THEN HAVING AN 5316 03:29:37,066 --> 03:29:37,667 OPERATIONAL DEFINITION COMING 5317 03:29:37,667 --> 03:29:41,237 OUT OF THIS SO THAT WE'RE 5318 03:29:41,237 --> 03:29:43,539 COLLECTING DATA THAT IS SIMILAR, 5319 03:29:43,539 --> 03:29:46,976 AND THAT WE CAN SYNTHESIZE TO 5320 03:29:46,976 --> 03:29:49,012 ULTIMATELY UNDERSTAND THE IMPACT 5321 03:29:49,012 --> 03:29:49,912 OF THE ENVIRONMENT GOING BEYOND 5322 03:29:49,912 --> 03:29:51,180 ONE EXPOSURE AT A TIME. 5323 03:29:51,180 --> 03:29:54,417 YOU ASKED A GREAT QUESTION. 5324 03:29:54,417 --> 03:29:56,386 >> YEAH, AND I'LL JUST CLARIFY 5325 03:29:56,386 --> 03:29:58,521 IT WASN'T A CRITICISM OF THE 5326 03:29:58,521 --> 03:29:59,322 IDEA AT ALL. 5327 03:29:59,322 --> 03:30:03,893 IT WAS -- BECAUSE I APPLAUD THAT 5328 03:30:03,893 --> 03:30:04,627 NOTION, ABSOLUTELY. 5329 03:30:04,627 --> 03:30:07,330 IT'S MORE THINKING ABOUT THE 5330 03:30:07,330 --> 03:30:09,599 MISSION STATEMENT AND THE 5331 03:30:09,599 --> 03:30:10,733 ABILITY TO EXPLICITLY DEAL WITH 5332 03:30:10,733 --> 03:30:13,269 SOMETHING THAT I THINK WE ALL 5333 03:30:13,269 --> 03:30:16,139 THINK ABOUT, WHICH IS THAT 5334 03:30:16,139 --> 03:30:17,106 IMMENSE COMPLEXITY. 5335 03:30:17,106 --> 03:30:18,574 THE MORE YOU CAN DEFINE THAT AS 5336 03:30:18,574 --> 03:30:21,444 THE ISSUE AND HOW IT WILL BE 5337 03:30:21,444 --> 03:30:24,180 ADDRESSED, I THINK THE MORE KIND 5338 03:30:24,180 --> 03:30:27,083 OF BUY-IN THAT WILL HELP TO 5339 03:30:27,083 --> 03:30:28,217 ACHIEVE. 5340 03:30:28,217 --> 03:30:29,185 >> AGAIN, THESE ARE GREAT YES, 5341 03:30:29,185 --> 03:30:30,853 SIR, AND FROM MY POINT OF VIEW 5342 03:30:30,853 --> 03:30:32,655 AT NIEHS WE'VE BEEN TALKING 5343 03:30:32,655 --> 03:30:35,191 ABOUT THIS NOW FOR A NUMBER OF 5344 03:30:35,191 --> 03:30:36,993 YEARS, LIKE 20 YEARS. 5345 03:30:36,993 --> 03:30:39,295 BUT WE NEED TO JUST STOP NOW AND 5346 03:30:39,295 --> 03:30:41,864 START THINKING NOT JUST ABOUT 5347 03:30:41,864 --> 03:30:46,002 DISCUSSING THE CONCEPT BUT START 5348 03:30:46,002 --> 03:30:47,570 OPERATIONALIZING IT AND, AGAIN, 5349 03:30:47,570 --> 03:30:50,039 WITH THE MUCH APPRECIATION FROM 5350 03:30:50,039 --> 03:30:51,307 NINDS, FOR YOUR SUPPORT, YOU 5351 03:30:51,307 --> 03:30:55,511 WERE REAL PARTNERS WITH US IN 5352 03:30:55,511 --> 03:30:59,182 FUNDING THE NEXUS CENTER, AND 5353 03:30:59,182 --> 03:31:00,883 THE PURPOSE, GRAY, TO DO 5354 03:31:00,883 --> 03:31:03,019 PRECISELY WHAT YOU'RE ASKING. 5355 03:31:03,019 --> 03:31:04,987 LET'S GET THE WORLD COMMUNITY 5356 03:31:04,987 --> 03:31:06,689 ENGAGED, DEFINE HOW TO 5357 03:31:06,689 --> 03:31:07,123 OPERATIONALIZE THIS. 5358 03:31:07,123 --> 03:31:08,624 WE HAVE ONE CENTER, NOT MULTIPLE 5359 03:31:08,624 --> 03:31:11,260 COMPETING WITH EACH OTHER BUT 5360 03:31:11,260 --> 03:31:12,762 ONE CENTER ENGAGING GLOBAL 5361 03:31:12,762 --> 03:31:14,330 COMMUNITY TO OPERATIONALIZE THE 5362 03:31:14,330 --> 03:31:17,667 EXPOSOME AND WE'LL HOLD THEM 5363 03:31:17,667 --> 03:31:20,636 ACCOUNTABLE FOR DELIVERING THAT. 5364 03:31:20,636 --> 03:31:29,345 DAVID OR WALTER, DO YOU AGREE 5365 03:31:29,345 --> 03:31:30,213 WITH THAT? 5366 03:31:30,213 --> 03:31:31,514 >> EPIGENETICS IS WHERE WE'RE AT 5367 03:31:31,514 --> 03:31:35,885 RIGHT NOW BUT I'M GLAD YOU SAID 5368 03:31:35,885 --> 03:31:37,253 THAT. 5369 03:31:37,253 --> 03:31:39,956 >> THERE MAY BE OTHER BIOLOGICAL 5370 03:31:39,956 --> 03:31:42,191 RESPONSES, EPIGENETIC IS ONE OF 5371 03:31:42,191 --> 03:31:44,560 THEM, BUT THAT'S AN AREA THAT I 5372 03:31:44,560 --> 03:31:47,029 THINK WE KNOW THAT'S PLAYING A 5373 03:31:47,029 --> 03:31:49,999 ROLE BUT HAVEN'T TAPPED INTO IT 5374 03:31:49,999 --> 03:31:54,036 AND BROUGHT THAT TO A LEVEL OF 5375 03:31:54,036 --> 03:31:57,673 SOPHISTICATION THAT WE NEED TO 5376 03:31:57,673 --> 03:31:59,008 DO MORE WITH THAT. 5377 03:31:59,008 --> 03:32:05,415 THERE ARE PROBABLY OTHER 5378 03:32:05,415 --> 03:32:05,815 QUESTIONS. 5379 03:32:05,815 --> 03:32:06,849 >> VERY GOOD. 5380 03:32:06,849 --> 03:32:12,121 WE'RE LOOKING FORWARD TO WORKING 5381 03:32:12,121 --> 03:32:12,488 WITH YOU, RICK. 5382 03:32:12,488 --> 03:32:14,724 I'D LIKE TO GET FROM 5383 03:32:14,724 --> 03:32:16,692 ASSOCIATIONS TO CAUSATION AND DO 5384 03:32:16,692 --> 03:32:19,429 INTERVENTION TO FIND OUT IF 5385 03:32:19,429 --> 03:32:20,163 WE'RE REALLY ONTO SOMETHING. 5386 03:32:20,163 --> 03:32:23,599 BUT IT'S GOING TO BE A GREAT 5387 03:32:23,599 --> 03:32:24,434 PARTNERSHIP GOING FORWARD. 5388 03:32:24,434 --> 03:32:25,768 THANKS FOR JOINING. 5389 03:32:25,768 --> 03:32:26,736 >> WALTER, IT'S BEEN A GREAT 5390 03:32:26,736 --> 03:32:27,637 PARTNERSHIP UP TO THIS POINT. 5391 03:32:27,637 --> 03:32:32,275 THANK YOU FOR YOUR INTEREST AND 5392 03:32:32,275 --> 03:32:33,109 YOUR WILLINGNESS TO COLLABORATE. 5393 03:32:33,109 --> 03:32:34,977 THAT'S THE WAY THIS IS GOING TO 5394 03:32:34,977 --> 03:32:37,246 WORK, JUST LIKE THE GENOME 5395 03:32:37,246 --> 03:32:38,047 PROJECT. 5396 03:32:38,047 --> 03:32:38,848 I USED THE ANALOGY THAT 30 YEARS 5397 03:32:38,848 --> 03:32:43,352 AGO IF YOU WERE DOING GENETICS 5398 03:32:43,352 --> 03:32:46,823 AND GENOMICS YOU WERE AT NHGRI 5399 03:32:46,823 --> 03:32:49,592 OR FUNDED BY THEM. 5400 03:32:49,592 --> 03:32:51,027 TO DR. COLLINS' AND DR. GREEN'S 5401 03:32:51,027 --> 03:32:52,261 CREDIT IT'S NOW BECOME INTEGRAL 5402 03:32:52,261 --> 03:32:54,096 TO THE WAY WE STUDY ETIOLOGY OF 5403 03:32:54,096 --> 03:32:54,530 DISEASE. 5404 03:32:54,530 --> 03:32:56,699 WE NEED TO DO THE SAME WITH 5405 03:32:56,699 --> 03:32:57,700 EXPOSOMICS. 5406 03:32:57,700 --> 03:33:01,471 WE'LL WORK ON THAT. 5407 03:33:01,471 --> 03:33:04,407 THANKS FOR YOUR INPUT. 5408 03:33:04,407 --> 03:33:05,808 AND YOUR COLLABORATION. 5409 03:33:05,808 --> 03:33:06,342 >> THANKS. 5410 03:33:06,342 --> 03:33:10,947 SO WE NEED TO VOTE ON THIS. 5411 03:33:10,947 --> 03:33:16,986 CAN I HAVE A MOTION TO ACCEPT 5412 03:33:16,986 --> 03:33:19,622 THE IMPLEMENTATION PLAN? 5413 03:33:19,622 --> 03:33:19,922 >> I MOVE. 5414 03:33:19,922 --> 03:33:21,591 >> THANK YOU. 5415 03:33:21,591 --> 03:33:23,025 AND SECOND? 5416 03:33:23,025 --> 03:33:23,793 >> SECOND. 5417 03:33:23,793 --> 03:33:25,661 >> THANKS YOU. 5418 03:33:25,661 --> 03:33:26,362 OKAY. 5419 03:33:26,362 --> 03:33:35,304 VOTING, PLEASE DO IT AUDIBLY, 5420 03:33:35,304 --> 03:33:36,506 STARTING WITH AMY. 5421 03:33:36,506 --> 03:33:40,209 >> OH, SORRY. 5422 03:33:40,209 --> 03:33:40,877 OKAY. 5423 03:33:40,877 --> 03:33:41,043 BOB. 5424 03:33:41,043 --> 03:33:42,712 >> YES, WE HAVEN'T HAD MUCH 5425 03:33:42,712 --> 03:33:44,213 DISCUSSION OF BUDGET THOUGH BUT 5426 03:33:44,213 --> 03:33:46,649 I'M GOING TO VOTE YES ANYWAY. 5427 03:33:46,649 --> 03:33:51,120 >> WE NEED TO BACK IT UP AND 5428 03:33:51,120 --> 03:33:51,988 DISCUSS BUDGET? 5429 03:33:51,988 --> 03:33:56,726 DO WE NEED TO BACK IT UP AND 5430 03:33:56,726 --> 03:33:57,293 DISCUSS BUDGET? 5431 03:33:57,293 --> 03:34:01,731 >> FOR THE REASONS WE TALKED 5432 03:34:01,731 --> 03:34:04,200 ABOUT EARLIER, SO, YEAH, WE 5433 03:34:04,200 --> 03:34:05,535 HAVEN'T REALLY BEEN ABLE TO KIND 5434 03:34:05,535 --> 03:34:07,703 OF PUT ANY KIND OF SET-ASIDE 5435 03:34:07,703 --> 03:34:10,439 MONEY AT THIS POINT IN TIME. 5436 03:34:10,439 --> 03:34:11,007 >> YEAH. 5437 03:34:11,007 --> 03:34:13,910 >> BUT WE'LL COME TO YOU, YEAH, 5438 03:34:13,910 --> 03:34:17,213 WITH INITIATIVES WHEN THEY 5439 03:34:17,213 --> 03:34:18,214 CERTAINLY, YEAH, INITIATIVES -- 5440 03:34:18,214 --> 03:34:21,918 BEFORE WE DO ANYTHING IN THIS 5441 03:34:21,918 --> 03:34:22,318 SPACE. 5442 03:34:22,318 --> 03:34:23,886 >> HARD TO KNOW WHAT WE'RE 5443 03:34:23,886 --> 03:34:25,421 VOTING FOR OTHER THAN SAYING 5444 03:34:25,421 --> 03:34:27,223 YES, THESE ARE ALL GOOD IDEAS. 5445 03:34:27,223 --> 03:34:30,026 IN 5446 03:34:30,026 --> 03:34:31,794 THAT SENSE I CERTAINLY VOTE YES. 5447 03:34:31,794 --> 03:34:39,602 >> THAT'S WHERE WE ARE NOW, BOB. 5448 03:34:39,602 --> 03:34:39,969 YEAH, AGREE. 5449 03:34:39,969 --> 03:34:42,805 >> WE'LL CALL IT CONCEPTUAL 5450 03:34:42,805 --> 03:34:44,206 INTEGRATION AT THIS POINT. 5451 03:34:44,206 --> 03:34:44,407 OKAY. 5452 03:34:44,407 --> 03:34:48,210 BOB, THAT WAS A YES. 5453 03:34:48,210 --> 03:34:50,513 >> YES. 5454 03:34:50,513 --> 03:34:51,247 >> THANKS YOU. 5455 03:34:51,247 --> 03:34:52,248 YISHI? 5456 03:34:52,248 --> 03:34:53,983 >> I AGREE WITH BOB'S COMMENTS, 5457 03:34:53,983 --> 03:34:56,786 AS WELL AS GRAY'S COMMENTS ABOUT 5458 03:34:56,786 --> 03:34:57,353 SETTING GOALS. 5459 03:34:57,353 --> 03:35:06,095 >> THANK YOU. 5460 03:35:06,095 --> 03:35:09,065 SO NOTED. 5461 03:35:09,065 --> 03:35:11,834 JANE? 5462 03:35:11,834 --> 03:35:13,269 LET'S GO TO JIN MU. 5463 03:35:13,269 --> 03:35:13,536 >> YES. 5464 03:35:13,536 --> 03:35:14,770 >> THANK YOU. 5465 03:35:14,770 --> 03:35:15,171 JOHN? 5466 03:35:15,171 --> 03:35:16,672 >> YES. 5467 03:35:16,672 --> 03:35:17,673 >> LOUISE? 5468 03:35:17,673 --> 03:35:18,307 >> APPROVE. 5469 03:35:18,307 --> 03:35:21,911 >> THANK YOU. 5470 03:35:21,911 --> 03:35:22,111 HANK? 5471 03:35:22,111 --> 03:35:23,446 >> APPROVE. 5472 03:35:23,446 --> 03:35:24,647 >> OKAY. 5473 03:35:24,647 --> 03:35:27,917 DO WE KNOW WHERE -- WE HAVE 5474 03:35:27,917 --> 03:35:28,150 QUORUM. 5475 03:35:28,150 --> 03:35:30,920 THANK YOU. 5476 03:35:30,920 --> 03:35:31,954 THANK YOU VERY MUCH. 5477 03:35:31,954 --> 03:35:34,523 NEXT UP JEFF DIAMOND WITH THE 5478 03:35:34,523 --> 03:35:35,024 INTRAMURAL REPORT. 5479 03:35:35,024 --> 03:35:45,334 JEFF, ARE YOU ON? 5480 03:35:52,108 --> 03:35:54,176 YES, YOU ARE. 5481 03:35:54,176 --> 03:35:54,644 >> YES, I AM. 5482 03:35:54,644 --> 03:35:56,212 CAN YOU HEAR ME? 5483 03:35:56,212 --> 03:35:58,147 >> YES. 5484 03:35:58,147 --> 03:35:58,414 >> OKAY. 5485 03:35:58,414 --> 03:36:00,216 ALL RIGHT. 5486 03:36:00,216 --> 03:36:01,250 WELL, THANKS, EVERYONE. 5487 03:36:01,250 --> 03:36:02,685 I KNOW YOU'VE HAD A LONG DAY. 5488 03:36:02,685 --> 03:36:03,886 IT'S NOT OVER YET. 5489 03:36:03,886 --> 03:36:07,456 YOU STILL HAVE TO TALK ABOUT 5490 03:36:07,456 --> 03:36:09,925 PAIN, KIND OF HAVE BEEN TALKING 5491 03:36:09,925 --> 03:36:11,927 ABOUT PAIN MOST OF THE DAY. 5492 03:36:11,927 --> 03:36:16,766 HOPEFULLY THIS WON'T BE PAINFUL. 5493 03:36:16,766 --> 03:36:23,072 I'M HAPPY TO REPORT ON THE 5494 03:36:23,072 --> 03:36:24,206 INTRAMURAL PROGRAM. 5495 03:36:24,206 --> 03:36:27,777 I'D LIKE TO KEEP IT SIMPLE AND 5496 03:36:27,777 --> 03:36:31,814 TO BE HONEST QUITE POSITIVE, 5497 03:36:31,814 --> 03:36:33,149 WITH MAYBE ONE GLANCE AT SOME OF 5498 03:36:33,149 --> 03:36:34,684 THE REALITY WE'RE FACING BUT I'D 5499 03:36:34,684 --> 03:36:36,886 LIKE TO TALK ABOUT SOME COMINGS 5500 03:36:36,886 --> 03:36:40,022 AND GOINGS TO THE INTRAMURAL 5501 03:36:40,022 --> 03:36:43,492 PROGRAM, A COUPLE INTERESTING 5502 03:36:43,492 --> 03:36:44,126 DEVELOPMENTS ACROSS OUR 5503 03:36:44,126 --> 03:36:49,031 COMMUNITY, I LIKE TO TAKE TIME 5504 03:36:49,031 --> 03:36:51,567 TO JUST SIT AND REVEL IN SOME 5505 03:36:51,567 --> 03:36:54,003 SCIENCE THAT WE'RE DOING, AND 5506 03:36:54,003 --> 03:36:56,172 JUST SHOW YOU A SMALL SAMPLE OF 5507 03:36:56,172 --> 03:37:01,677 THE SCIENCE AND THEN JUST FINISH 5508 03:37:01,677 --> 03:37:07,650 WITH AN UPDATE ON A LITTLE BIT 5509 03:37:07,650 --> 03:37:08,984 OF SUMMARY OF THE PRODUCTIVITY 5510 03:37:08,984 --> 03:37:14,457 ACROSS THE PROGRAM. 5511 03:37:14,457 --> 03:37:19,161 SO, HELLO THAT I'M HAPPY ABOUT 5512 03:37:19,161 --> 03:37:21,464 TO LET YOU KNOW THAT WE'VE 5513 03:37:21,464 --> 03:37:23,966 APPOINTED A DEPUTY SCIENTIFIC 5514 03:37:23,966 --> 03:37:26,869 DIRECTOR, AND THAT'S LUCY 5515 03:37:26,869 --> 03:37:28,204 FOREST, A SENIOR INVESTIGATOR IN 5516 03:37:28,204 --> 03:37:32,508 THE INSTITUTE, CHIEF OF THE 5517 03:37:32,508 --> 03:37:35,678 COMPUTATIONAL STRUCTURAL BIOLOGY 5518 03:37:35,678 --> 03:37:35,911 SECTION. 5519 03:37:35,911 --> 03:37:39,949 SHE USES, AS I SAY HERE, SHE 5520 03:37:39,949 --> 03:37:40,483 USES COMPLEX COMPUTATIONAL 5521 03:37:40,483 --> 03:37:42,518 METHODS TO STUDY STRUCTURE OF 5522 03:37:42,518 --> 03:37:47,056 MEMBRANE PROTEINS AND TO SEE HOW 5523 03:37:47,056 --> 03:37:48,157 PARTICULAR MOTIFS REPEAT WITHIN 5524 03:37:48,157 --> 03:37:51,360 PROTEINS AND ARE COMMON ACROSS 5525 03:37:51,360 --> 03:37:51,627 PROTEINS. 5526 03:37:51,627 --> 03:37:53,863 IT'S REALLY BEAUTIFUL WORK, YOU 5527 03:37:53,863 --> 03:37:58,100 CAN SEE FROM THIS LITTLE BIO 5528 03:37:58,100 --> 03:37:59,568 THAT LUCY PING PONGS ACROSS THE 5529 03:37:59,568 --> 03:38:01,670 ATLANTA SEVERAL TIMES. 5530 03:38:01,670 --> 03:38:04,206 HOPE THE PING PONG BALL HAS 5531 03:38:04,206 --> 03:38:05,274 STOPPED BOUNCING. 5532 03:38:05,274 --> 03:38:08,744 SHE'S A TERRIFIC ADDITION TO 5533 03:38:08,744 --> 03:38:11,881 YOUR INTRAMURAL PROGRAM, IN A 5534 03:38:11,881 --> 03:38:13,883 SHORT TIME SHE'S BEEN A 5535 03:38:13,883 --> 03:38:16,152 FANTASTIC ADDITION TO OUR 5536 03:38:16,152 --> 03:38:16,385 OFFICE. 5537 03:38:16,385 --> 03:38:18,387 SO I'M REALLY HAPPY THAT LUCY 5538 03:38:18,387 --> 03:38:25,661 AGREED TO TAKE ON THIS ROLE. 5539 03:38:25,661 --> 03:38:29,665 WE HAVE HAD SOME MOVEMENT IN 5540 03:38:29,665 --> 03:38:32,201 TERMS OF OUR FACULTY, IN THE 5541 03:38:32,201 --> 03:38:36,005 LAST YEAR, WE'VE WELCOMED TWO 5542 03:38:36,005 --> 03:38:40,576 NEW TENURE TRACK INVESTIGATORS, 5543 03:38:40,576 --> 03:38:45,447 CHRIS GRUNSEICA AND AMREEN 5544 03:38:45,447 --> 03:38:48,217 MUGHAL, INTEGRATING WELL IN THE 5545 03:38:48,217 --> 03:38:48,484 COMMUNITY. 5546 03:38:48,484 --> 03:38:52,221 CHRIS WAS HERE AS A CLINICAL 5547 03:38:52,221 --> 03:38:56,225 FELLOW, AND SO HE IS STAFF 5548 03:38:56,225 --> 03:39:00,062 CLINICIAN, WAS QUITE WELL 5549 03:39:00,062 --> 03:39:00,362 INTEGRATED. 5550 03:39:00,362 --> 03:39:03,232 WE'RE ALSO RECRUITING TWO NEW 5551 03:39:03,232 --> 03:39:07,002 P.I.s, BOTH ON THE CLINICAL 5552 03:39:07,002 --> 03:39:09,638 SIDE, AND THEY IN THE 5553 03:39:09,638 --> 03:39:16,612 NEUROIMMUNOLOGY BRANCH AND 5554 03:39:16,612 --> 03:39:17,446 SURGICAL NEUROLOGY BRANCH 5555 03:39:17,446 --> 03:39:19,915 REFLECT THE SUCCESS OF TWO 5556 03:39:19,915 --> 03:39:21,283 CLINICAL INVESTIGATORS THAT HAVE 5557 03:39:21,283 --> 03:39:23,686 BEEN REVIEWED POSITIVELY BY THE 5558 03:39:23,686 --> 03:39:26,789 BOARD OF SCIENTIFIC COUNSELORS 5559 03:39:26,789 --> 03:39:29,859 AND WE'RE LOOKING TO ADVANCE 5560 03:39:29,859 --> 03:39:33,629 THEM TO THE TENURE TRACK. 5561 03:39:33,629 --> 03:39:43,439 WE HAD TWO INVESTIGATORS TENURED 5562 03:39:43,439 --> 03:39:49,445 IN 2024, ARIEL LEVINE AND SONIA 5563 03:39:49,445 --> 03:39:50,145 SCHOL DIS 5564 03:39:50,145 --> 03:39:53,616 AN EASY JOB TO MAKE THE CASE FOR 5565 03:39:53,616 --> 03:39:55,584 THEM WITH THE CENTRAL TENURE 5566 03:39:55,584 --> 03:39:57,086 COMMITTEE. 5567 03:39:57,086 --> 03:40:02,191 TWO CASES COMING UP, DEREK IS ON 5568 03:40:02,191 --> 03:40:04,193 THE SCHEDULE, HE WILL BE 5569 03:40:04,193 --> 03:40:07,630 PRESENTED ON AUGUST 4, AND YI GU 5570 03:40:07,630 --> 03:40:11,467 WILL FOLLOW NOT SO CLOSE BEHIND. 5571 03:40:11,467 --> 03:40:13,869 NOT SO FAR BEHIND, ACTUALLY, 5572 03:40:13,869 --> 03:40:14,503 SORRY. 5573 03:40:14,503 --> 03:40:18,941 SO, WE'VE ALSO HAD SOME 5574 03:40:18,941 --> 03:40:19,408 RETIREMENTS. 5575 03:40:19,408 --> 03:40:22,011 THERE HAVE BEEN A NUMBER OF 5576 03:40:22,011 --> 03:40:24,213 RETIREMENTS IN THE LAST COUPLE 5577 03:40:24,213 --> 03:40:25,147 YEARS. 5578 03:40:25,147 --> 03:40:31,287 THIS YEAR DAVID GOLDSTEIN AND 5579 03:40:31,287 --> 03:40:33,656 DAVID SIBLEY TWO SENIOR 5580 03:40:33,656 --> 03:40:34,857 INVESTIGATORS AND LONGTIME 5581 03:40:34,857 --> 03:40:38,894 CONTRIBUTORS TO THE COMMUNITY 5582 03:40:38,894 --> 03:40:40,930 RETIRED. 5583 03:40:40,930 --> 03:40:42,798 GOLDSTEIN APPROVED AS SCIENTIST 5584 03:40:42,798 --> 03:40:44,400 EMERITUS BY COMMITTEE OF 5585 03:40:44,400 --> 03:40:44,900 SCIENTIFIC AND CLINICAL 5586 03:40:44,900 --> 03:40:47,503 DIRECTORS, AND I WILL BE 5587 03:40:47,503 --> 03:40:50,839 PRESENTING DAVE SIBLEY IN THE 5588 03:40:50,839 --> 03:40:53,742 NEAR FUTURE, AND I EXPECT THAT 5589 03:40:53,742 --> 03:40:56,979 TO BE APPROVED UNANIMOUSLY BY 5590 03:40:56,979 --> 03:40:59,415 THE SCIENTIFIC AND CLINICAL 5591 03:40:59,415 --> 03:41:00,115 DIRECTORS. 5592 03:41:00,115 --> 03:41:02,117 RETIREMENTS, IT'S ALWAYS SAD TO 5593 03:41:02,117 --> 03:41:05,654 SEE PEOPLE GO BUT IT'S KIND OF A 5594 03:41:05,654 --> 03:41:08,824 HAPPY OCCASION, SOMEWHAT MORE 5595 03:41:08,824 --> 03:41:12,194 BITTERSWEET OCCASION IS TO MARK 5596 03:41:12,194 --> 03:41:18,334 THE DEPARTURE OF WEI LU, SENIOR 5597 03:41:18,334 --> 03:41:18,901 INVESTIGATOR, A PRODUCTIVE 5598 03:41:18,901 --> 03:41:21,403 MEMBER, I'LL TALK ABOUT THE WORK 5599 03:41:21,403 --> 03:41:27,843 WITH.EI DID -- WEI DID, DECIDED 5600 03:41:27,843 --> 03:41:30,980 TO MOVE TO AN OPPORTUNITY IN 5601 03:41:30,980 --> 03:41:34,917 SHANGHAI, WE WISH WEI THE BEST, 5602 03:41:34,917 --> 03:41:40,356 WE'RE SO THAT HE WAS COMPELLED 5603 03:41:40,356 --> 03:41:44,760 TO MOVE ON BUT HE WAS A GREAT 5604 03:41:44,760 --> 03:41:46,795 CONTRIBUTOR TO OUR COMMUNITY 5605 03:41:46,795 --> 03:41:48,897 WHEN HE WAS HERE. 5606 03:41:48,897 --> 03:41:51,700 IT WAS A SAD YEAR IN THAT WE 5607 03:41:51,700 --> 03:41:58,674 LOST A NUMBER OF REAL PILLARS OF 5608 03:41:58,674 --> 03:42:00,009 THE NINDS INTRAMURAL PROGRAM, WE 5609 03:42:00,009 --> 03:42:02,511 LOST THESE FOUR INDIVIDUALS THIS 5610 03:42:02,511 --> 03:42:09,418 YEAR, BOB BURKE, PETER FISHMAN, 5611 03:42:09,418 --> 03:42:11,620 TOM REESE, JOHN HALENBECK. 5612 03:42:11,620 --> 03:42:12,821 EACH MADE SIGNIFICANT 5613 03:42:12,821 --> 03:42:16,191 CONTRIBUTIONS, WE JUST LAST WEEK 5614 03:42:16,191 --> 03:42:18,827 HAD A REALLY NICE SYMPOSIUM 5615 03:42:18,827 --> 03:42:21,864 HONORING THE MEMORY OF TOM 5616 03:42:21,864 --> 03:42:27,536 REESE, IT WAS REALLY A NICE 5617 03:42:27,536 --> 03:42:28,203 EVENT. 5618 03:42:28,203 --> 03:42:34,476 ALL OF THESE SCIENTISTS WILL BE 5619 03:42:34,476 --> 03:42:35,310 FONDLY REMEMBERED. 5620 03:42:35,310 --> 03:42:36,745 SO, WE'VE TALKED ABOUT COMINGS 5621 03:42:36,745 --> 03:42:38,047 AND GOINGS. 5622 03:42:38,047 --> 03:42:42,584 WE HAVE A NUMBER OF PEOPLE WHO 5623 03:42:42,584 --> 03:42:44,987 ARE IN LIMBO. 5624 03:42:44,987 --> 03:42:47,389 I THINK YOU'VE HEARD ABOUT ABOUT 5625 03:42:47,389 --> 03:42:48,824 REDUCTION IN FORCE, GIVING RISE 5626 03:42:48,824 --> 03:42:53,095 TO A NEW WORD IN OUR LEXICON, 5627 03:42:53,095 --> 03:42:58,333 RIF, A NOUN, A VERB, AN 5628 03:42:58,333 --> 03:43:00,202 EXPLETIVE. 5629 03:43:00,202 --> 03:43:02,971 IT'S BEEN A VERY DIFFICULT 5630 03:43:02,971 --> 03:43:03,172 THING. 5631 03:43:03,172 --> 03:43:05,207 WE LOWEST A LOT OF PEOPLE ACROSS 5632 03:43:05,207 --> 03:43:07,009 THE INSTITUTE TO THE REDUCTION 5633 03:43:07,009 --> 03:43:07,910 IN FORCE, LOST A LOT OF GOOD 5634 03:43:07,910 --> 03:43:09,445 PEOPLE IN THE DIVISION OF 5635 03:43:09,445 --> 03:43:11,413 EXTRAMURAL RESEARCH, OFFICE OF 5636 03:43:11,413 --> 03:43:14,450 THE DIRECTOR, AND ALSO THE 5637 03:43:14,450 --> 03:43:16,685 DIVISION OF INTRAMURAL RESEARCH. 5638 03:43:16,685 --> 03:43:22,825 BUT AS PART OF THIS THE PROCESS 5639 03:43:22,825 --> 03:43:23,559 ACTUALLY ACCIDENTALLY RIFFED 30 5640 03:43:23,559 --> 03:43:26,628 PEOPLE DUE TO AN ERROR IN 5641 03:43:26,628 --> 03:43:30,666 INTERPRETING SOME KIND OF H.R. 5642 03:43:30,666 --> 03:43:31,500 CODE. 5643 03:43:31,500 --> 03:43:34,636 AND SO THERE WERE 30 PEOPLE WHO 5644 03:43:34,636 --> 03:43:37,339 WERE RIFFED WHO WEREN'T MEANT TO 5645 03:43:37,339 --> 03:43:42,845 BE, AND ALL OF THOSE PEOPLE ARE 5646 03:43:42,845 --> 03:43:43,245 MISSED. 5647 03:43:43,245 --> 03:43:49,985 I'M FOCUSING ON 11 OF THOSE 30 5648 03:43:49,985 --> 03:43:51,720 WHO WERE SENIOR INVESTIGATORS, 5649 03:43:51,720 --> 03:43:53,288 BECAUSE -- NOT BECAUSE THEY ARE 5650 03:43:53,288 --> 03:43:54,523 MORE IMPORTANT ALTHOUGH THEY ARE 5651 03:43:54,523 --> 03:43:58,393 PRETTY IMPORTANT, BUT EACH OF 5652 03:43:58,393 --> 03:44:00,162 THEM DIRECTS MATURE LABS WITH A 5653 03:44:00,162 --> 03:44:03,332 LOT OF EXCELLENT SCIENTISTS SO 5654 03:44:03,332 --> 03:44:04,666 WHILE IT LOOKS LIKE 11 PEOPLE 5655 03:44:04,666 --> 03:44:07,469 HERE ARE SITTING IN LIMBO, THEY 5656 03:44:07,469 --> 03:44:11,106 WERE RIFFED ON APRIL 1, THEY 5657 03:44:11,106 --> 03:44:12,541 HAVE BEEN TOLD THAT THESE RIFs 5658 03:44:12,541 --> 03:44:15,711 WERE MADE IN ERROR AND WILL BE 5659 03:44:15,711 --> 03:44:16,311 RESCINDED. 5660 03:44:16,311 --> 03:44:20,282 THEY HAVE NOT BEEN RESCINDED 5661 03:44:20,282 --> 03:44:21,683 YET. 5662 03:44:21,683 --> 03:44:24,186 AND THEY ARE FACING THE PROSPECT 5663 03:44:24,186 --> 03:44:28,657 OF BEING LET GO ON JUNE 2, A 5664 03:44:28,657 --> 03:44:30,092 NUMBER OF THESE PEOPLE ARE -- 5665 03:44:30,092 --> 03:44:32,494 WELL, THEY ARE ALL VERY ANXIOUS, 5666 03:44:32,494 --> 03:44:33,929 SOME ARE WORRIED ABOUT THEIR 5667 03:44:33,929 --> 03:44:35,764 STATUS WITH REGARD TO RETIREMENT 5668 03:44:35,764 --> 03:44:36,665 AND SO FORTH. 5669 03:44:36,665 --> 03:44:38,367 BUT I WANT TO BRING THIS UP 5670 03:44:38,367 --> 03:44:40,402 BECAUSE THERE ARE 11 PEOPLE, BUT 5671 03:44:40,402 --> 03:44:43,872 WITHIN THEIR LABS THERE'S A MUCH 5672 03:44:43,872 --> 03:44:45,541 LARGER NUMBER OF SCIENTISTS, A 5673 03:44:45,541 --> 03:44:46,508 LOT OF YOUNG TRAINEES AT THE 5674 03:44:46,508 --> 03:44:48,210 BEGINNING OF THEIR CAREERS WHO 5675 03:44:48,210 --> 03:44:51,880 ARE ALSO IN LIMBO. 5676 03:44:51,880 --> 03:44:53,415 AND ARE VERY ANXIOUS ABOUT 5677 03:44:53,415 --> 03:44:57,953 WHAT'S GOING TO HAPPEN. 5678 03:44:57,953 --> 03:45:00,856 WE REMAIN HOPEFUL THAT THIS RIF 5679 03:45:00,856 --> 03:45:01,990 ACTION WILL BE RESCINDED BUT 5680 03:45:01,990 --> 03:45:03,926 KIND OF EVERY DAY THAT PASSES 5681 03:45:03,926 --> 03:45:10,065 THAT GETS CLOSER TO JUNE 2, THE 5682 03:45:10,065 --> 03:45:12,935 ANXIETY LEVEL OF THESE, YOU 5683 03:45:12,935 --> 03:45:15,704 KNOW, 107 PEOPLE IN PARTICULAR 5684 03:45:15,704 --> 03:45:19,775 PLUS THE OTHER 19 PEOPLE, IT 5685 03:45:19,775 --> 03:45:23,645 CONTINUES TO REMAIN HIGH. 5686 03:45:23,645 --> 03:45:23,845 OKAY. 5687 03:45:23,845 --> 03:45:26,548 I WANT TO TALK ABOUT TWO THINGS 5688 03:45:26,548 --> 03:45:30,185 THAT HAVE HAPPENED IN THE 5689 03:45:30,185 --> 03:45:30,686 COMMUNITY. 5690 03:45:30,686 --> 03:45:34,656 LAST YEAR, I RELATED TO YOU THAT 5691 03:45:34,656 --> 03:45:37,159 THE FELLOWS AT NIH WHO HAD 5692 03:45:37,159 --> 03:45:40,262 ORGANIZED INTO AN ORGANIZATION 5693 03:45:40,262 --> 03:45:43,131 CALLED NIH FELLOWS UNITED 5694 03:45:43,131 --> 03:45:47,903 ELECTED TO BE REPRESENTED BY THE 5695 03:45:47,903 --> 03:45:51,406 UNITED AUTO WORKERS UNION, AND 5696 03:45:51,406 --> 03:45:55,344 THERE WAS AN EXTENSIVE 5697 03:45:55,344 --> 03:45:56,211 BARGAINING SESSION THROUGHOUT 5698 03:45:56,211 --> 03:45:59,948 2024, AND IN DECEMBER OF 2024 5699 03:45:59,948 --> 03:46:03,752 NIH AND U.A.W. FINISHED THEIR 5700 03:46:03,752 --> 03:46:04,753 NEGOTIATIONS OF COLLECTIVE 5701 03:46:04,753 --> 03:46:06,655 BARGAINING AGREEMENT RATIFIED BY 5702 03:46:06,655 --> 03:46:09,124 THE UNION AND ALMOST IMMEDIATELY 5703 03:46:09,124 --> 03:46:10,459 SIGNED BY THE DEPARTMENT OF 5704 03:46:10,459 --> 03:46:12,661 HEALTH AND HUMAN SERVICES. 5705 03:46:12,661 --> 03:46:15,797 AND THAT WENT INTO EFFECT IN 5706 03:46:15,797 --> 03:46:18,033 JANUARY, AND THE OFFICE OF 5707 03:46:18,033 --> 03:46:20,035 INTRAMURAL TRAINING AND 5708 03:46:20,035 --> 03:46:23,005 EDUCATION HAS BEEN WORKING TO 5709 03:46:23,005 --> 03:46:27,042 ADAPT THE POLICIES THAT WE HAVE 5710 03:46:27,042 --> 03:46:30,245 FOR FELLOWS ACROSS THE NIH TO 5711 03:46:30,245 --> 03:46:31,446 FULLY SATISFY THE REQUIREMENTS 5712 03:46:31,446 --> 03:46:35,450 OF THE COLLECTIVE BARGAINING 5713 03:46:35,450 --> 03:46:37,019 AGREEMENT, AND I THINK JUST THIS 5714 03:46:37,019 --> 03:46:40,756 MIGHT OF MY PERSONAL IMPRESSION 5715 03:46:40,756 --> 03:46:42,824 OF THE AGREEMENT THAT THE 5716 03:46:42,824 --> 03:46:47,696 AGREEMENT IS VERY VALUABLE IN 5717 03:46:47,696 --> 03:46:49,765 THAT IT PROTECTS FELLOWS FROM 5718 03:46:49,765 --> 03:46:50,632 POTENTIALLY BAD SITUATIONS. 5719 03:46:50,632 --> 03:46:54,703 I THINK THE LARGE MAJORITY OF 5720 03:46:54,703 --> 03:46:58,740 THE SUPERVISORS ACROSS NIH ARE 5721 03:46:58,740 --> 03:47:00,542 GOOD BOSSES BUT OCCASIONALLY YOU 5722 03:47:00,542 --> 03:47:03,145 RUN INTO A SITUATION THAT'S 5723 03:47:03,145 --> 03:47:04,780 PROBLEMATIC AND A FELLOW FEELS 5724 03:47:04,780 --> 03:47:08,650 LIKE THEY HAVE VERY IT'S 5725 03:47:08,650 --> 03:47:10,819 LEVER -- LITTLE LEVERAGE AND THE 5726 03:47:10,819 --> 03:47:12,888 UNION AGREEMENT CAN GO A LONG 5727 03:47:12,888 --> 03:47:20,629 WAY TO GIVING THE FELLOWS SOME 5728 03:47:20,629 --> 03:47:22,864 SUPPORT IN THOSE SITUATIONS. 5729 03:47:22,864 --> 03:47:27,035 ANOTHER REALLY NICE THING THAT'S 5730 03:47:27,035 --> 03:47:27,869 DEVELOPING IN OUR COMMITTEE 5731 03:47:27,869 --> 03:47:31,473 WITHIN NINDS IS THE STAFF 5732 03:47:31,473 --> 03:47:33,575 SCIENTISTS AND CLINICIAN 5733 03:47:33,575 --> 03:47:35,677 ASSOCIATION, AND THIS IS I THINK 5734 03:47:35,677 --> 03:47:37,412 A RECOGNITION WITHIN THAT 5735 03:47:37,412 --> 03:47:39,047 COMMUNITY THAT WE SPEND A LOT OF 5736 03:47:39,047 --> 03:47:42,984 TIME WORRYING ABOUT THE FELLOWS 5737 03:47:42,984 --> 03:47:44,920 AND THE P.I.s, YOU KNOW, 5738 03:47:44,920 --> 03:47:47,022 CONTROL THE LAB BUDGETS AND 5739 03:47:47,022 --> 03:47:47,322 EVERYTHING. 5740 03:47:47,322 --> 03:47:52,961 IN BETWEEN ARE THE STAFF 5741 03:47:52,961 --> 03:47:56,732 SCIENTISTS AND STAFF CLINICIANS, 5742 03:47:56,732 --> 03:47:58,266 RELATIVELY SENIOR, HIGHLY 5743 03:47:58,266 --> 03:47:59,835 ACCOMPLISHED SCIENTISTS AND 5744 03:47:59,835 --> 03:48:03,972 CLINICIANS WHO CONTRIBUTE A 5745 03:48:03,972 --> 03:48:04,973 TREMENDOUS AMOUNT IN VARIOUS 5746 03:48:04,973 --> 03:48:07,008 WAYS, BOTH IN THE LAB, IN THE 5747 03:48:07,008 --> 03:48:09,244 CLINIC, AND IN THE COMMUNITY. 5748 03:48:09,244 --> 03:48:11,646 AND SO THIS ASSOCIATION HAS 5749 03:48:11,646 --> 03:48:13,081 BROUGHT THEM TOGETHER AND THEY 5750 03:48:13,081 --> 03:48:14,483 CAN DISCUSS AND SUPPORT -- THEY 5751 03:48:14,483 --> 03:48:17,552 CAN DISCUSS ISSUES AND SUPPORT 5752 03:48:17,552 --> 03:48:18,420 ONE ANOTHER. 5753 03:48:18,420 --> 03:48:20,555 THEY HAVE MEETINGS FOUR TIMES A 5754 03:48:20,555 --> 03:48:22,257 YEAR WITH ME. 5755 03:48:22,257 --> 03:48:26,395 AND THOSE MEETINGS HAVE BEEN 5756 03:48:26,395 --> 03:48:28,864 GREAT AND PRODUCTIVE. 5757 03:48:28,864 --> 03:48:32,567 THEY CONTRIBUTE TO THE 5758 03:48:32,567 --> 03:48:34,369 INTRAMURAL STAFF RETREAT. 5759 03:48:34,369 --> 03:48:36,972 AND WE'VE DEVELOPED TOGETHER 5760 03:48:36,972 --> 03:48:39,641 WITH THEM SOME WORKSHOPS TO HELP 5761 03:48:39,641 --> 03:48:44,813 THEM, BOTH WORKSHOPS TO HELP 5762 03:48:44,813 --> 03:48:46,515 THEM NEGOTIATE THE ANNUAL AND 5763 03:48:46,515 --> 03:48:47,282 QUADRENNIAL EVALUATIONS THEY 5764 03:48:47,282 --> 03:48:50,452 HAVE TO GO THROUGH AND WE 5765 03:48:50,452 --> 03:48:52,154 RECENTLY HAD A DAY-LONG TRAINING 5766 03:48:52,154 --> 03:48:53,789 WORKSHOP TO HELP THEM DEVELOP 5767 03:48:53,789 --> 03:48:55,991 LEADERSHIP SKILLS. 5768 03:48:55,991 --> 03:48:57,526 IT'S BEEN A NICE I THINK 5769 03:48:57,526 --> 03:49:01,163 ORGANIZATION TO SUPPORT THIS 5770 03:49:01,163 --> 03:49:03,064 PART OF THE PROGRAM. 5771 03:49:03,064 --> 03:49:03,632 OKAY. 5772 03:49:03,632 --> 03:49:09,604 I'D LIKE TO TAKE A FEW MINUTES 5773 03:49:09,604 --> 03:49:13,275 TO TALK ABOUT A FEW OF THE 5774 03:49:13,275 --> 03:49:14,342 PROJECTS THAT HAVE COME OUT OF 5775 03:49:14,342 --> 03:49:17,813 THE INTRAMURAL PROGRAM IN THE 5776 03:49:17,813 --> 03:49:18,547 LAST YEAR. 5777 03:49:18,547 --> 03:49:21,049 AND I REALIZE NOW THAT A COUPLE 5778 03:49:21,049 --> 03:49:24,219 OF THESE FIRST FEW ARE IN THE 5779 03:49:24,219 --> 03:49:28,990 SAME VEIN. 5780 03:49:28,990 --> 03:49:30,225 JOHN SHOWED NICE BEAUTIFUL 5781 03:49:30,225 --> 03:49:32,060 RESULTS SUPPORTED BY THE BRAIN 5782 03:49:32,060 --> 03:49:34,463 INITIATIVE, THE VALUE OF 5783 03:49:34,463 --> 03:49:35,464 RECORDING FROM ESSENTIALLY EVERY 5784 03:49:35,464 --> 03:49:42,337 NEURON IN A REGION OF THE 5785 03:49:42,337 --> 03:49:43,305 CORTEX, THE FIRST THREE PAPERS 5786 03:49:43,305 --> 03:49:46,241 SHOW THE VALUE OF REPORTING FROM 5787 03:49:46,241 --> 03:49:48,743 A NUMBER OF THEM. 5788 03:49:48,743 --> 03:49:58,186 AND THE FIRST PAPER COMES FROM 5789 03:49:58,186 --> 03:50:01,490 KARINNE'S LAB, IN PATIENTS THAT 5790 03:50:01,490 --> 03:50:02,424 HE'S TREATING SURGICALLY THEY 5791 03:50:02,424 --> 03:50:06,161 HAVE THE OPPORTUNITY TO RECORD 5792 03:50:06,161 --> 03:50:09,898 FROM THE CORTEX OF THESE 5793 03:50:09,898 --> 03:50:13,568 PATIENTS, ANTERIOR TEMPORAL LOBE 5794 03:50:13,568 --> 03:50:16,338 AND HAVE THE PATIENTS DO TASKS 5795 03:50:16,338 --> 03:50:17,873 WHILE RECORDING FROM DIFFERENT 5796 03:50:17,873 --> 03:50:24,946 BRAIN REGIONS, AND IN THIS CASE 5797 03:50:24,946 --> 03:50:29,818 THE TASK IS TO LOOK AT A NATURAL 5798 03:50:29,818 --> 03:50:32,187 IMAGE, TO CHARACTERIZE THE 5799 03:50:32,187 --> 03:50:33,655 OBJECT AS ANIMAL, PLACE, PERSON, 5800 03:50:33,655 --> 03:50:40,829 AND THEN RECORDING FROM A NUMBER 5801 03:50:40,829 --> 03:50:42,697 OF INDIVIDUAL NEURONS SO YOU 5802 03:50:42,697 --> 03:50:44,132 MIGHT NOT BE SURPRISED THAT IN 5803 03:50:44,132 --> 03:50:45,800 RESPONSE TO A PARTICULAR OBJECT 5804 03:50:45,800 --> 03:50:47,869 YOU SEE A BURST OF ACTIVITY 5805 03:50:47,869 --> 03:50:49,137 ACROSS A NUMBER OF NEURONS, BUT 5806 03:50:49,137 --> 03:50:51,773 IF YOU ZOOM IN ON THE TIMING OF 5807 03:50:51,773 --> 03:50:55,076 THESE BURSTS YOU SEE THAT THE 5808 03:50:55,076 --> 03:51:00,048 NEURONS FIRE IN A PARTICULAR 5809 03:51:00,048 --> 03:51:00,882 SEQUENCE THAT CHANGES WHETHER 5810 03:51:00,882 --> 03:51:02,817 THEY ARE VIEWING AN ANIMAL, AN 5811 03:51:02,817 --> 03:51:06,555 OBJECT, A PLACE, OR A PERSON. 5812 03:51:06,555 --> 03:51:09,658 AND SO WHAT KAREEM AND LAB HAVE 5813 03:51:09,658 --> 03:51:11,593 SHOWN IS THESE SEQUENCES ADD 5814 03:51:11,593 --> 03:51:12,928 INFORMATION THAT IS DISTINCT 5815 03:51:12,928 --> 03:51:16,364 FROM THE PEAK FIRING RATE OR THE 5816 03:51:16,364 --> 03:51:20,368 AVERAGE DELAY OR THE TIME OF THE 5817 03:51:20,368 --> 03:51:21,903 OVERALL BURST, AND SO THESE 5818 03:51:21,903 --> 03:51:23,638 SEQUENCES HAVE A LOT OF EXTRA 5819 03:51:23,638 --> 03:51:26,975 INFORMATION AND YOU CAN SEE OVER 5820 03:51:26,975 --> 03:51:29,844 HERE THAT IT ALLOWS THEM TO 5821 03:51:29,844 --> 03:51:31,479 DISTINGUISH IMAGES OF QUITE 5822 03:51:31,479 --> 03:51:33,481 DISTINCTLY EVENING WITHIN ONE OF 5823 03:51:33,481 --> 03:51:36,217 THESE LARGER CATEGORIES, FOR 5824 03:51:36,217 --> 03:51:40,555 EXAMPLE, THIS IS ANY OLD PERSON, 5825 03:51:40,555 --> 03:51:42,090 ACTUALLY NOT ANY OL' PERSON, 5826 03:51:42,090 --> 03:51:43,925 IT'S ACTUALLY KAREEM. 5827 03:51:43,925 --> 03:51:46,528 BUT THAT'S DISTINCT AND THEY 5828 03:51:46,528 --> 03:51:47,996 SHOWED PEOPLE ARE ABLE TO 5829 03:51:47,996 --> 03:51:50,031 DISTINGUISH AND PROVIDE 5830 03:51:50,031 --> 03:51:51,199 DIFFERENT SEQUENCES FOR 5831 03:51:51,199 --> 03:51:58,506 DIFFERENT FAMOUS PEOPLE, FOR 5832 03:51:58,506 --> 03:51:59,774 EXAMPLE, THESE FOUR DIFFERENT 5833 03:51:59,774 --> 03:52:01,076 PRESENCE, THE LATEST IN WHAT HAS 5834 03:52:01,076 --> 03:52:04,145 BEEN JUST A WONDERFUL SERIES OF 5835 03:52:04,145 --> 03:52:10,552 REALLY INTERESTING STUDIES 5836 03:52:10,552 --> 03:52:12,220 COMING FROM KAREEM'S LAB. 5837 03:52:12,220 --> 03:52:16,191 MARK WAGNER IS A YOUNG 5838 03:52:16,191 --> 03:52:20,061 INVESTIGATOR. 5839 03:52:20,061 --> 03:52:22,063 HE JUST HAD HIS FIRST BSC REVIEW 5840 03:52:22,063 --> 03:52:26,468 AND IS STUDYING HOW THE 5841 03:52:26,468 --> 03:52:33,975 CEREBELLUM AND TOGETHER WITH THE 5842 03:52:33,975 --> 03:52:36,011 CORTEX COMPUTES DIFFERENT TASKS, 5843 03:52:36,011 --> 03:52:37,312 SKILLED LEARNING, HOW TO ENCODE 5844 03:52:37,312 --> 03:52:40,749 REWARD, AND WHAT HE'S BEEN ABLE 5845 03:52:40,749 --> 03:52:47,989 TO DO IS RECORD USING TWO PHOTON 5846 03:52:47,989 --> 03:52:48,957 MICROSCOPY FROM CEREBELLAR CELLS 5847 03:52:48,957 --> 03:52:50,558 AND CLIMBING FIBERS AT THE SAME 5848 03:52:50,558 --> 03:52:51,226 TIME. 5849 03:52:51,226 --> 03:52:53,261 AND SO -- CLIMBING FIBER 5850 03:52:53,261 --> 03:52:55,964 ACTIVITY AT LEAST, IMAGES OF 5851 03:52:55,964 --> 03:53:00,468 CEREBELLAR GRANULE CELLS AND 5852 03:53:00,468 --> 03:53:02,671 PURKINJE THAT GIVE A GOOD 5853 03:53:02,671 --> 03:53:06,007 READOUT WHEN A CLIMBING FIBER 5854 03:53:06,007 --> 03:53:10,912 FIRES AND LIGHTS UP THE PURKINJE 5855 03:53:10,912 --> 03:53:15,183 CELL DENDRITES IN AN AWAKE 5856 03:53:15,183 --> 03:53:16,317 BEHAVING MOUSE, CAN DO THIS 5857 03:53:16,317 --> 03:53:20,188 SEVERAL DAYS AT DIFFERENT TIMES 5858 03:53:20,188 --> 03:53:21,189 DURING LEARNING, AND IMAGE THE 5859 03:53:21,189 --> 03:53:22,891 ACTIVITY OF THE SAME CELLS AND 5860 03:53:22,891 --> 03:53:25,760 WHAT HE DOES IS HE -- THEY TRAIN 5861 03:53:25,760 --> 03:53:28,596 THE MOUSE SO THAT IT MOVES THIS 5862 03:53:28,596 --> 03:53:30,331 LEVER AND THEN RECEIVES A REWARD 5863 03:53:30,331 --> 03:53:31,232 FOR DOING THAT. 5864 03:53:31,232 --> 03:53:33,034 AND YOU CAN SEE IN THE GREEN 5865 03:53:33,034 --> 03:53:33,968 WHEN THE MOUSE FIRST STARTS 5866 03:53:33,968 --> 03:53:36,571 THIS, AS SOON AS THEY MOVE THE 5867 03:53:36,571 --> 03:53:37,972 LEVER THEY ARE EXPECTING A 5868 03:53:37,972 --> 03:53:40,208 REWARD VERY QUICKLY SO THEY 5869 03:53:40,208 --> 03:53:40,542 START LICKING. 5870 03:53:40,542 --> 03:53:43,178 BUT THE REWARD DOESN'T COME FOR 5871 03:53:43,178 --> 03:53:44,145 AN ENTIRE SECOND AFTERWARDS. 5872 03:53:44,145 --> 03:53:46,414 AND AFTER A WHILE THE MOUSE 5873 03:53:46,414 --> 03:53:49,217 LEARNS THIS AND IS ABLE TO 5874 03:53:49,217 --> 03:53:50,552 MODULATE HIS LICKING OVER AN 5875 03:53:50,552 --> 03:53:52,721 EXTENDED PERIOD OF TIME. 5876 03:53:52,721 --> 03:53:55,056 SO THE MOUSE IS LEARNING TO 5877 03:53:55,056 --> 03:53:56,191 ANTICIPATE THE REWARD THAT'S 5878 03:53:56,191 --> 03:53:59,160 HAPPENING OVER A MUCH LONGER 5879 03:53:59,160 --> 03:54:00,762 DELAY WHICH IS INTERESTING 5880 03:54:00,762 --> 03:54:02,897 BECAUSE THE LEARNING RULES IN 5881 03:54:02,897 --> 03:54:05,900 THE CEREBELLUM OPERATE IN TIME 5882 03:54:05,900 --> 03:54:09,604 BUT USUALLY WITH MUCH SMALLER 5883 03:54:09,604 --> 03:54:13,041 DELAYS BETWEEN THE GRANULAR 5884 03:54:13,041 --> 03:54:15,410 CELLS AND PURKINJE CELLS, 150 5885 03:54:15,410 --> 03:54:17,679 MILLISECONDS IS THE LEARNING 5886 03:54:17,679 --> 03:54:21,082 WINDOW, BUT HERE THEY ARE ABLE 5887 03:54:21,082 --> 03:54:22,917 TO ENCODE REWARD DELAYS OVER A 5888 03:54:22,917 --> 03:54:23,151 SECOND. 5889 03:54:23,151 --> 03:54:25,286 IN FACT, YOU CAN TRAIN A MOUSE 5890 03:54:25,286 --> 03:54:27,789 TO LEARN TO ENCODE OVER A SECOND 5891 03:54:27,789 --> 03:54:30,191 AND YOU CAN RETRAIN THEM AND HE 5892 03:54:30,191 --> 03:54:32,193 LEARNS TO STRETCH TO TWO 5893 03:54:32,193 --> 03:54:32,427 SECONDS. 5894 03:54:32,427 --> 03:54:35,630 THEY LOOKED AT THE RECORDINGS IN 5895 03:54:35,630 --> 03:54:37,398 INDIVIDUAL GRANULE CELLS, HERE 5896 03:54:37,398 --> 03:54:39,100 YOU CAN SEE RECORDINGS FROM 5897 03:54:39,100 --> 03:54:43,972 THOUSANDS OF THEM, AND THESE ARE 5898 03:54:43,972 --> 03:54:47,942 THE -- SORTED BY PEAK ACTIVITY, 5899 03:54:47,942 --> 03:54:49,177 AND THIS IS THE TIME THEY MOVE 5900 03:54:49,177 --> 03:54:51,179 THE LEVER, AND THIS IS THE TIME 5901 03:54:51,179 --> 03:54:52,213 OF THE REWARD. 5902 03:54:52,213 --> 03:54:55,283 CAN YOU SEE FOR A LOT OF GRANULE 5903 03:54:55,283 --> 03:54:56,785 CELLS ACTIVITY SPREADS OUT IN 5904 03:54:56,785 --> 03:54:59,587 TIME OVER HERE. 5905 03:54:59,587 --> 03:55:00,655 THEY ARE ADJUSTING THE 5906 03:55:00,655 --> 03:55:03,291 POPULATION, VARYING THE TIME OF 5907 03:55:03,291 --> 03:55:05,426 THEIR ACTIVITY, IN ORDER TO 5908 03:55:05,426 --> 03:55:08,663 ENCODE A MUCH LONGER DELAY 5909 03:55:08,663 --> 03:55:10,465 BETWEEN THE MOTOR ACTION AND THE 5910 03:55:10,465 --> 03:55:13,768 REWARD. 5911 03:55:13,768 --> 03:55:14,769 AND THEY DID SOME BEAUTIFUL 5912 03:55:14,769 --> 03:55:16,371 CONTROLS FOR THIS. 5913 03:55:16,371 --> 03:55:17,105 SO IT'S REMARKABLE. 5914 03:55:17,105 --> 03:55:19,374 AND THEY ARE ABLE TO RECORD FROM 5915 03:55:19,374 --> 03:55:23,745 THE GRANULE CELLS, AND ALSO THE 5916 03:55:23,745 --> 03:55:26,848 CLIMBING FIBERS ACTIVITY WHICH 5917 03:55:26,848 --> 03:55:30,718 IS TYPICALLY VERY TIGHTLY 5918 03:55:30,718 --> 03:55:35,857 COUPLED HERE TO THE REWARD. 5919 03:55:35,857 --> 03:55:41,329 TIMING IS ALSO IMPORTANT IN 5920 03:55:41,329 --> 03:55:42,730 SPATIAL NAVIGATION, AND ANOTHER 5921 03:55:42,730 --> 03:55:44,465 TENURE TRACK INVESTIGATOR HAS 5922 03:55:44,465 --> 03:55:48,403 BEEN STUDYING THIS IN MICE IN A 5923 03:55:48,403 --> 03:55:49,571 VIRTUAL REALITY ARENA. 5924 03:55:49,571 --> 03:55:52,207 AND THEY CAN GO ALONG AND THERE 5925 03:55:52,207 --> 03:55:56,311 ARE AREAS THEY CAN STOP AND GET 5926 03:55:56,311 --> 03:56:01,082 A REWARD, AND IN THE PAST SHE'S 5927 03:56:01,082 --> 03:56:02,517 SHOWN HOW ANIMALS USE VISUAL 5928 03:56:02,517 --> 03:56:03,651 CUES TO FIND THESE. 5929 03:56:03,651 --> 03:56:06,955 I THINK IN THE FIELD IT'S 5930 03:56:06,955 --> 03:56:10,992 BEEN -- THERE'S SOME WHO THINK 5931 03:56:10,992 --> 03:56:14,062 THAT THE ENTORHINAL CORTEX MAPS 5932 03:56:14,062 --> 03:56:16,264 THIS OUT AGNOSTIC TO THE SENSORY 5933 03:56:16,264 --> 03:56:18,666 INPUT, DOESN'T MATTER WHETHER 5934 03:56:18,666 --> 03:56:21,636 IT'S VISUAL OR AUDITORY OR 5935 03:56:21,636 --> 03:56:21,903 OLFACTORY. 5936 03:56:21,903 --> 03:56:25,340 YI AND HER LAB TOOK A LOOK AT 5937 03:56:25,340 --> 03:56:28,710 THIS AND YOU CAN SEE DOWN HERE 5938 03:56:28,710 --> 03:56:32,180 THAT THE ANIMAL WOULD GO THROUGH 5939 03:56:32,180 --> 03:56:35,283 A LONG -- THROUGH A VIRTUAL 5940 03:56:35,283 --> 03:56:36,150 REALITY ENVIRONMENT, AND THERE 5941 03:56:36,150 --> 03:56:39,254 WOULD BE AREAS WHERE THEY WOULD 5942 03:56:39,254 --> 03:56:41,122 GET AUDITORY CUES OR VISUAL 5943 03:56:41,122 --> 03:56:44,359 CUES, AND THERE WERE AREAS WHERE 5944 03:56:44,359 --> 03:56:46,494 THOSE CUES WOULD BE ASSOCIATED 5945 03:56:46,494 --> 03:56:48,196 WITH REWARDS, AND IF THEY LOOKED 5946 03:56:48,196 --> 03:56:49,797 AT SOME OF THE ANIMALS, SORRY, 5947 03:56:49,797 --> 03:56:53,968 SOME OF THE CELLS, THEY WOULD 5948 03:56:53,968 --> 03:56:57,639 SEE SOME CELLS RESPOND TO 5949 03:56:57,639 --> 03:56:58,973 AUDITORY-ASSOCIATED REWARD ZONES 5950 03:56:58,973 --> 03:57:01,342 AND OTHER CELLS RESPOND ONLY TO 5951 03:57:01,342 --> 03:57:02,677 VISUAL REWARD ZONES. 5952 03:57:02,677 --> 03:57:04,345 THESE AREN'T JUST VISUAL CELLS 5953 03:57:04,345 --> 03:57:06,080 BECAUSE THERE ARE OTHER VISUAL 5954 03:57:06,080 --> 03:57:07,248 STIMULI THEY DON'T RESPOND TO 5955 03:57:07,248 --> 03:57:08,950 BUT IT'S THE AREAS WHERE THEY 5956 03:57:08,950 --> 03:57:11,219 KNOW THERE'S ALSO A REWARD. 5957 03:57:11,219 --> 03:57:15,056 SO, SHE'S SHOWN THERE ARE CELLS 5958 03:57:15,056 --> 03:57:16,758 THAT ARE ACTUALLY ONLY AUDITORY 5959 03:57:16,758 --> 03:57:21,396 OR VISUAL, NOT BOTH, AL ALTHOUH 5960 03:57:21,396 --> 03:57:25,033 THERE IS A POPULATION OF 5961 03:57:25,033 --> 03:57:26,935 MULTI-MODAL CELLS THAT ENCODE 5962 03:57:26,935 --> 03:57:35,743 BOTH AUDITORY AND VISUAL 5963 03:57:35,743 --> 03:57:36,411 STIMULI. 5964 03:57:36,411 --> 03:57:37,679 WE'VE LOST WEI, ENJOYED HAVING 5965 03:57:37,679 --> 03:57:38,346 HIM HERE. 5966 03:57:38,346 --> 03:57:43,785 HE SPENT A LOT OF HIS TIME HERE 5967 03:57:43,785 --> 03:57:47,388 LOOKING AT THE MOLECULAR BASES 5968 03:57:47,388 --> 03:57:48,389 OF SYNAPSE DEVELOPMENT. 5969 03:57:48,389 --> 03:57:51,826 HE SPENT A LOT OF HIS CAREER 5970 03:57:51,826 --> 03:57:57,065 INTERESTED IN EXCITATORY 5971 03:57:57,065 --> 03:57:58,833 SYNAPSIS AND BECAME MORE 5972 03:57:58,833 --> 03:58:00,668 INTERESTED IN INHIBITORY 5973 03:58:00,668 --> 03:58:04,205 SYNAPSIS, HE IDENTIFIED A 5974 03:58:04,205 --> 03:58:07,675 PROTEIN THAT AT THE TIME 5975 03:58:07,675 --> 03:58:12,080 FUNCTION WASN'T REALLY KNOWN, 5976 03:58:12,080 --> 03:58:12,814 TMEM-132B, INTERESTING BECAUSE 5977 03:58:12,814 --> 03:58:15,249 IT WAS REDUCED IN HUMANS WHO 5978 03:58:15,249 --> 03:58:20,755 SUFFERED FROM ALCOHOL USE 5979 03:58:20,755 --> 03:58:21,255 DISORDER. 5980 03:58:21,255 --> 03:58:31,165 AND HE CHARACTERIZED THIS 5981 03:58:31,165 --> 03:58:32,667 PROTEIN, ASSOCIATED WITH GABA 5982 03:58:32,667 --> 03:58:34,202 RECEPTOR, AUXILIARY PROTEIN, 5983 03:58:34,202 --> 03:58:36,237 INTERESTING BECAUSE AS YOU KNOW 5984 03:58:36,237 --> 03:58:40,108 A LOT OF EFFECTS ON THE BRAIN 5985 03:58:40,108 --> 03:58:42,710 DUE TO ALCOHOL INVOLVE GABA-A 5986 03:58:42,710 --> 03:58:46,214 RECEPTORS, AND SO WHAT HE FOUND 5987 03:58:46,214 --> 03:58:50,485 WAS THAT THIS PROTEIN FIRST OF 5988 03:58:50,485 --> 03:58:53,921 ALL ENCOURAGED THE RECRUITMENT 5989 03:58:53,921 --> 03:58:55,289 OF GABA RECEPTORS TO INHIBITORY 5990 03:58:55,289 --> 03:58:59,260 SYNAPSES, IN THE KNOCKOUT A 5991 03:58:59,260 --> 03:59:03,297 REDUCTION IN NUMBER, THE PROTEIN 5992 03:59:03,297 --> 03:59:04,866 ENHANCES GABA RESENTER 5993 03:59:04,866 --> 03:59:08,803 SENSITIVITY TO TO ALCOHOL. 5994 03:59:08,803 --> 03:59:11,572 SO THIS WOULD SUGGEST THAT IT 5995 03:59:11,572 --> 03:59:12,507 MIGHT CONTRIBUTE TO BEHAVIORAL 5996 03:59:12,507 --> 03:59:16,878 RESPONSE TO ALCOHOL, AND IN FACT 5997 03:59:16,878 --> 03:59:18,479 THAT IS THE CASE. 5998 03:59:18,479 --> 03:59:22,650 TURNS OUT THAT WHEN A MOUSE 5999 03:59:22,650 --> 03:59:23,985 LEAVES THE PUB, HE'S MUCH MORE 6000 03:59:23,985 --> 03:59:28,356 LIKELY TO GO OUT AND WANDER INTO 6001 03:59:28,356 --> 03:59:29,424 OPEN SPACES, MICE OFTEN SPEND 6002 03:59:29,424 --> 03:59:36,731 MORE TIME IN ENCLOSED SPACES BUT 6003 03:59:36,731 --> 03:59:39,500 MICE WITH ALCOHOL ARE LESS 6004 03:59:39,500 --> 03:59:40,101 INHIBITED, REDUCED ANXIETY, 6005 03:59:40,101 --> 03:59:42,503 SPEND MORE TIME IN OPEN SPACE, 6006 03:59:42,503 --> 03:59:44,272 THIS TENDENCY IS REDUCED IN MICE 6007 03:59:44,272 --> 03:59:46,274 IN WHICH THIS PROTEIN IS KNOCKED 6008 03:59:46,274 --> 03:59:46,574 OUT. 6009 03:59:46,574 --> 03:59:51,512 TOGETHER WITH THAT IN THE 6010 03:59:51,512 --> 03:59:54,048 KNOCKOUT ALSO APPARENTLY ITS 6011 03:59:54,048 --> 03:59:55,483 SENSITIVITY TO BEING SATED WITH 6012 03:59:55,483 --> 03:59:57,618 ALCOHOL CHANGES SO IT'S MORE 6013 03:59:57,618 --> 04:00:00,788 INCLINED TO DRINK MORE ALCOHOL. 6014 04:00:00,788 --> 04:00:03,357 SO, THIS IS A REALLY INTERESTING 6015 04:00:03,357 --> 04:00:05,960 FINDING, AND I THINK IT'S 6016 04:00:05,960 --> 04:00:09,230 SOMETHING THAT WEI IS GOING TO 6017 04:00:09,230 --> 04:00:11,065 PURSUE, WE WISH HIM LUCK IN 6018 04:00:11,065 --> 04:00:12,200 SHANGHAI, AND I'M SURE WE'LL 6019 04:00:12,200 --> 04:00:21,943 HEAR A LOT MORE FROM HIM IN 6020 04:00:21,943 --> 04:00:22,310 LITERATURE. 6021 04:00:22,310 --> 04:00:24,178 I WANT TO FINISH WITH A PAPER 6022 04:00:24,178 --> 04:00:26,147 DEREK PUBLISHED AT THE END OF 6023 04:00:26,147 --> 04:00:35,823 2024, DEREK IS COMING UP FOR 6024 04:00:35,823 --> 04:00:36,424 TENURE, STUDIED MITOCHONDRIAL 6025 04:00:36,424 --> 04:00:38,960 FUNCTION AND IMPORTANT ROLE OF 6026 04:00:38,960 --> 04:00:46,934 REGULATION AND REPAIR OF 6027 04:00:46,934 --> 04:00:48,536 MITOCHONDRIA, PUBLISHED A PAPER 6028 04:00:48,536 --> 04:00:49,871 IN EMBO, IF YOU HAVE TIME I 6029 04:00:49,871 --> 04:00:52,073 RECOMMEND THAT YOU TAKE A LOOK 6030 04:00:52,073 --> 04:00:52,907 AT THIS. 6031 04:00:52,907 --> 04:00:59,714 GIVE YOURSELF TIME BECAUSE IT'S 6032 04:00:59,714 --> 04:01:01,949 A HUGE PAPER. 6033 04:01:01,949 --> 04:01:04,452 HE LOOKED AT ROLE OF A 6034 04:01:04,452 --> 04:01:08,156 MITOCHONDRIAL PROTEIN AND 6035 04:01:08,156 --> 04:01:11,259 EFFECTS OF DELE1 ON GROWTH -- 6036 04:01:11,259 --> 04:01:18,466 CELL GROWTH AND SURVIVAL IN THE 6037 04:01:18,466 --> 04:01:20,368 FACE OF FOUR DIFFERENT STRESSORS 6038 04:01:20,368 --> 04:01:22,236 ON MITOCHONDRIA, FOUR DIFFERENT 6039 04:01:22,236 --> 04:01:24,205 MOLECULAR MANIPULATIONS SO 6040 04:01:24,205 --> 04:01:27,675 LOOKING AT A NICE DIVERSITY OF 6041 04:01:27,675 --> 04:01:31,279 STRESSORS AND SHOWED THAT THE 6042 04:01:31,279 --> 04:01:33,581 SURVIVAL OF THE ANIMAL IS 6043 04:01:33,581 --> 04:01:36,184 REDUCED SIGNIFICANTLY IN ALL 6044 04:01:36,184 --> 04:01:39,520 CASES WHEN HE KNOCKS OUT DELE1. 6045 04:01:39,520 --> 04:01:42,590 WHAT HE SHOWED IN THE PAPER, AND 6046 04:01:42,590 --> 04:01:44,592 I CAN'T GET TOO DETAILED ABOUT 6047 04:01:44,592 --> 04:01:49,463 THIS, WAY OUT OF MY EXPERTISE, 6048 04:01:49,463 --> 04:01:52,233 BUT BASICALLY IN RESPONSE TO 6049 04:01:52,233 --> 04:01:55,770 THESE STRESSORS DELE 1 CAUSES OR 6050 04:01:55,770 --> 04:01:59,173 CONTRIBUTES TO INTEGRATED STRESS 6051 04:01:59,173 --> 04:02:00,007 RESPONSE WHICH RESULTS IN A 6052 04:02:00,007 --> 04:02:04,111 NUMBER OF GENES TO BE EXPRESSED 6053 04:02:04,111 --> 04:02:08,482 THAT HAVE EFFECTS ON METABOLISM, 6054 04:02:08,482 --> 04:02:13,821 AND OTHER PROCESSES THAT CAN 6055 04:02:13,821 --> 04:02:15,323 PROTECT THE CELL. 6056 04:02:15,323 --> 04:02:17,491 THE UPREGULATION OF THESE IS 6057 04:02:17,491 --> 04:02:23,264 DIMINISHED WHEN HE KNOCKS OUT 6058 04:02:23,264 --> 04:02:27,268 DELE1, SHOWING THIS IS NOT JUST 6059 04:02:27,268 --> 04:02:29,270 TRANSCRIPTOMIC BUT ALSO IS 6060 04:02:29,270 --> 04:02:29,870 IMPACTING PROTEIN EXPRESSION. 6061 04:02:29,870 --> 04:02:33,941 THIS IS A GRAPH OF THE CHANGE IN 6062 04:02:33,941 --> 04:02:38,379 PROTEIN EXPRESSION VERSUS THE 6063 04:02:38,379 --> 04:02:39,747 CHANGE IN TRANSCRIPT EXPRESSION. 6064 04:02:39,747 --> 04:02:43,851 SO, IT'S GOING TO BE FUN 6065 04:02:43,851 --> 04:02:44,785 PRESENTING DEREK'S CASE IN 6066 04:02:44,785 --> 04:02:45,253 AUGUST. 6067 04:02:45,253 --> 04:02:47,688 I THINK HE'S A VERY STRONG 6068 04:02:47,688 --> 04:02:49,890 CANDIDATE FOR TENURE. 6069 04:02:49,890 --> 04:02:52,660 AND I THINK CENTRAL TENURE 6070 04:02:52,660 --> 04:02:56,097 COMMITTEE IS LIKELY TO AGREE. 6071 04:02:56,097 --> 04:02:58,733 SO FINALLY I WANT TO UPDATE YOU 6072 04:02:58,733 --> 04:03:04,205 ON AND TELL YOU THAT THE 6073 04:03:04,205 --> 04:03:08,609 INTRAMURAL PROGRAM REMAINS VERY 6074 04:03:08,609 --> 04:03:10,378 CONSISTENTLY PRODUCTIVE, AND I 6075 04:03:10,378 --> 04:03:14,415 WOULD SAY THAT I THINK THIS IS 6076 04:03:14,415 --> 04:03:17,652 PRETTY REMARKABLE GIVEN THAT THE 6077 04:03:17,652 --> 04:03:19,754 REGION BETWEEN 2018 AND 2024 6078 04:03:19,754 --> 04:03:21,088 ENCOMPASSES COVID, WHICH WAS 6079 04:03:21,088 --> 04:03:23,524 DIFFICULT FOR EVERYONE, AS WELL 6080 04:03:23,524 --> 04:03:26,794 AS A MAJOR FLOOD THAT OCCURRED 6081 04:03:26,794 --> 04:03:28,195 IN ONE OF OUR BUILDINGS, 6082 04:03:28,195 --> 04:03:30,398 DRAMATICALLY INFLUENCING A 6083 04:03:30,398 --> 04:03:34,735 NUMBER OF OUR INVESTIGATORS. 6084 04:03:34,735 --> 04:03:35,803 SO, PEOPLE CONTINUED TO BE 6085 04:03:35,803 --> 04:03:36,203 PRODUCTIVE. 6086 04:03:36,203 --> 04:03:38,539 IF YOU LOOK AT THE WORD CLOUD OF 6087 04:03:38,539 --> 04:03:41,542 THE TITLES OF THOSE PAPERS YOU 6088 04:03:41,542 --> 04:03:43,711 CAN SEE THAT THEY ARE FOCUSED ON 6089 04:03:43,711 --> 04:03:46,814 SOME OF THE THINGS THAT YOU 6090 04:03:46,814 --> 04:03:48,316 WOULD WANT THE INTRAMURAL 6091 04:03:48,316 --> 04:03:52,219 PROGRAM TO BE, TO BE FOCUSED ON. 6092 04:03:52,219 --> 04:03:54,155 THERE'S A LOT OF WORK ON CHRONIC 6093 04:03:54,155 --> 04:03:59,260 DISEASE, ON THE ROOT CAUSE OF 6094 04:03:59,260 --> 04:04:02,163 THESE DISEASES, AND A WHOLE 6095 04:04:02,163 --> 04:04:02,997 RANGE OF INTERESTING TOPICS THAT 6096 04:04:02,997 --> 04:04:07,268 REALLY DO A NICE JOB OF COVERING 6097 04:04:07,268 --> 04:04:09,070 MANY INTERESTING PARTS OF THE 6098 04:04:09,070 --> 04:04:12,873 NEUROSCIENCE FIELD. 6099 04:04:12,873 --> 04:04:16,977 THIS IS JUST SHOWING THAT THIS 6100 04:04:16,977 --> 04:04:24,585 WORK IS BEING PRESENTED TO THE 6101 04:04:24,585 --> 04:04:26,620 WORLD IN WELL-RESPECTED 6102 04:04:26,620 --> 04:04:29,757 JOURNALS, AND THE MOST FUN THING 6103 04:04:29,757 --> 04:04:32,593 ABOUT THIS JOB IS THE 6104 04:04:32,593 --> 04:04:33,894 OPPORTUNITY TO SORT OF GET A 6105 04:04:33,894 --> 04:04:36,297 HANDLE ON THE WORK THAT'S BEING 6106 04:04:36,297 --> 04:04:43,838 DONE ALL ACROSS THE INTRAMURAL 6107 04:04:43,838 --> 04:04:45,439 PROGRAM TO SEE PEOPLE BEING, YOU 6108 04:04:45,439 --> 04:04:48,075 KNOW, EVALUATED DURING THE BOARD 6109 04:04:48,075 --> 04:04:49,310 OF SCIENTIFIC COUNSELORS AND 6110 04:04:49,310 --> 04:04:53,714 WONDERFUL WAY THEY PRESENT THEIR 6111 04:04:53,714 --> 04:04:53,914 WORK. 6112 04:04:53,914 --> 04:04:58,386 SO, I'LL STOP THERE AND IF 6113 04:04:58,386 --> 04:05:01,122 ANYBODY HAS ANY QUESTIONS. 6114 04:05:01,122 --> 04:05:03,491 >> JEFF, THANK YOU SO MUCH FOR 6115 04:05:03,491 --> 04:05:04,191 THAT OVERVIEW. 6116 04:05:04,191 --> 04:05:06,327 AND YOU SAID YOU WOULD TELL US 6117 04:05:06,327 --> 04:05:10,064 ABOUT COOL SCIENCE, COOL INDEED. 6118 04:05:10,064 --> 04:05:11,732 ALWAYS NICE TO SEE HIGH IMPACT 6119 04:05:11,732 --> 04:05:13,267 WORK OUT OF THE INTRAMURAL 6120 04:05:13,267 --> 04:05:14,802 PROGRAM UNDER YOUR LEADERSHIP. 6121 04:05:14,802 --> 04:05:18,539 YOU PROBABLY WEREN'T THERE WHEN 6122 04:05:18,539 --> 04:05:19,607 WE HEARD FROM DR. BHATTACHARYA 6123 04:05:19,607 --> 04:05:19,874 TODAY. 6124 04:05:19,874 --> 04:05:21,275 HE DID NOT TALK ABOUT THE 6125 04:05:21,275 --> 04:05:22,743 INTRAMURAL PROGRAM MUCH. 6126 04:05:22,743 --> 04:05:23,677 WE DIDN'T TALK ABOUT THE ISSUE 6127 04:05:23,677 --> 04:05:28,182 OF THE FACT THAT THERE WAS AN 6128 04:05:28,182 --> 04:05:31,051 ERRONEOUS AND TRAGIC RIFFING OF 6129 04:05:31,051 --> 04:05:33,654 MANY PEOPLE INCLUDING LEADING 6130 04:05:33,654 --> 04:05:34,722 SCIENTISTS. 6131 04:05:34,722 --> 04:05:36,690 THAT SAID, IT'S TRULY MADDENING 6132 04:05:36,690 --> 04:05:38,159 TO THINK THAT THEY MIGHT NOT BE 6133 04:05:38,159 --> 04:05:39,827 RESTORED AND THERE'S A RISK OF 6134 04:05:39,827 --> 04:05:43,130 CATASTROPHE HERE IF THEY ARE NOT 6135 04:05:43,130 --> 04:05:43,397 RESTORED. 6136 04:05:43,397 --> 04:05:43,831 IT'S UNUSUAL TIMES. 6137 04:05:43,831 --> 04:05:45,733 I DON'T KNOW IF IT'S BEYOND OUR 6138 04:05:45,733 --> 04:05:48,202 PURVIEW AS COUNCIL MEMBERS BUT I 6139 04:05:48,202 --> 04:05:51,906 PERSONALLY WOULD ADVOCATE WE AS 6140 04:05:51,906 --> 04:05:53,073 COUNCIL MAKE IT CLEAR ESPECIALLY 6141 04:05:53,073 --> 04:05:54,542 TO WALTER AND PERHAPS IN SOME 6142 04:05:54,542 --> 04:05:57,278 WAY ADDRESS THIS TO DR. 6143 04:05:57,278 --> 04:05:58,946 BHATTACHARYA, THAT WE THINK IT 6144 04:05:58,946 --> 04:06:01,148 IS ESSENTIAL THAT THESE 6145 04:06:01,148 --> 04:06:02,450 INDIVIDUALS BE RESTORED BY THE 6146 04:06:02,450 --> 04:06:06,554 JUNE 2 DEADLINE FOR THE SAKE OF 6147 04:06:06,554 --> 04:06:07,154 CONTINUING GOOD GRADE SCIENCE 6148 04:06:07,154 --> 04:06:10,257 THAT HITS AT BRAIN HEALTH, 6149 04:06:10,257 --> 04:06:12,193 CHRONIC DISEASES, AND ENSURES 6150 04:06:12,193 --> 04:06:13,761 THAT SCIENCE AT NIH AND NINDS 6151 04:06:13,761 --> 04:06:15,496 CONTINUES THE WAY IT SHOULD. 6152 04:06:15,496 --> 04:06:18,666 I'D LOVE TO HEAR WHETHER THAT'S 6153 04:06:18,666 --> 04:06:19,733 WITHIN OUR PURVIEW AS COUNCIL TO 6154 04:06:19,733 --> 04:06:20,201 DO THAT. 6155 04:06:20,201 --> 04:06:27,041 MAYBE NOT YOURS TO ANSWER, MAYBE 6156 04:06:27,041 --> 04:06:27,641 IT'S WALTER'S. 6157 04:06:27,641 --> 04:06:28,509 >> WELL, I'LL JUST LET WALTER 6158 04:06:28,509 --> 04:06:30,044 CHIME IN BUT I WOULD JUST SAY 6159 04:06:30,044 --> 04:06:35,749 ONE OF THE FRUSTRATIONS THAT WE 6160 04:06:35,749 --> 04:06:37,485 FACE AS FEDERAL EMPLOYEES IS, 6161 04:06:37,485 --> 04:06:41,255 YOU KNOW, WE'RE VERY RESTRICTED 6162 04:06:41,255 --> 04:06:44,158 FROM APPEALING DIRECTLY TO THE 6163 04:06:44,158 --> 04:06:47,461 POWERS THAT BE. 6164 04:06:47,461 --> 04:06:50,865 I THINK THAT THE SUPPORT OF 6165 04:06:50,865 --> 04:06:53,901 COUNCIL WOULD BE VERY IMPORTANT. 6166 04:06:53,901 --> 04:06:56,804 YOU MAY HAVE HEARD THAT IN 6167 04:06:56,804 --> 04:06:59,573 ANOTHER INSTITUTE THERE WERE 6168 04:06:59,573 --> 04:07:04,645 SOME YOUNGER SCIENTISTS WHO WERE 6169 04:07:04,645 --> 04:07:06,647 RIF'ed, THE BSC SENT A LETTER 6170 04:07:06,647 --> 04:07:08,148 TO CONGRESS THAT LOOKS LIKE IT 6171 04:07:08,148 --> 04:07:12,186 WAS QUITE EFFECTIVE BECAUSE 6172 04:07:12,186 --> 04:07:15,189 THOSE PEOPLE WERE REINSTATED. 6173 04:07:15,189 --> 04:07:18,792 I FEEL WE'VE GOTTEN A LOT OF 6174 04:07:18,792 --> 04:07:19,693 REASSURANCES THAT THIS 6175 04:07:19,693 --> 04:07:23,163 REINSTATEMENT WOULD OCCUR. 6176 04:07:23,163 --> 04:07:28,202 I REMAIN, TO BE HONEST, VERY 6177 04:07:28,202 --> 04:07:32,940 CONCERNED ABOUT WHAT WILL HAPPEN 6178 04:07:32,940 --> 04:07:36,644 TO THE INTRAMURAL PROGRAM IF ALL 6179 04:07:36,644 --> 04:07:39,380 FEATURES OF THE PROPOSED BUDGET 6180 04:07:39,380 --> 04:07:41,549 GO THROUGH. 6181 04:07:41,549 --> 04:07:46,153 PART OF THAT INVOLVES EXPECTED 6182 04:07:46,153 --> 04:07:49,690 DEPARTURE OF, TO BE HONEST, MOST 6183 04:07:49,690 --> 04:07:50,991 OF OUR SENIOR SCIENTISTS, MOST 6184 04:07:50,991 --> 04:07:53,527 OF OUR CLINICIANS BY VIRTUE OF 6185 04:07:53,527 --> 04:07:59,199 ASKING PEOPLE ABOVE A CERTAIN 6186 04:07:59,199 --> 04:08:00,401 PAY GRADE TO RESIGN. 6187 04:08:00,401 --> 04:08:04,138 I'M VERY WORRIED ABOUT THAT. 6188 04:08:04,138 --> 04:08:06,674 >> THANK YOU FOR EXPRESSING YOUR 6189 04:08:06,674 --> 04:08:07,074 TRANSPARENT VIEWS. 6190 04:08:07,074 --> 04:08:09,376 WALTER, ARE WE IN A POSITION 6191 04:08:09,376 --> 04:08:13,380 WHERE WE COULD ADVOCATE 6192 04:08:13,380 --> 04:08:15,215 EXPLICITLY TO THE NIH DIRECTOR 6193 04:08:15,215 --> 04:08:18,852 THE VITAL IMPORTANCE MAKING SURE 6194 04:08:18,852 --> 04:08:20,821 THIS HAPPENS BY JUNE 2? 6195 04:08:20,821 --> 04:08:24,191 >> YEAH, I THINK THE COUNCIL IS 6196 04:08:24,191 --> 04:08:27,328 APPOINTED BY THE SECRETARY, AND 6197 04:08:27,328 --> 04:08:35,102 NIH DIRECTOR'S IN THAT LINE, SO 6198 04:08:35,102 --> 04:08:37,104 IF THE COUNCIL WANTED TO COMPOSE 6199 04:08:37,104 --> 04:08:39,239 A LETTER I'M SURE THAT WOULD BE 6200 04:08:39,239 --> 04:08:39,440 FINE. 6201 04:08:39,440 --> 04:08:40,808 HE HAS ON MULTIPLE OCCASIONS 6202 04:08:40,808 --> 04:08:44,878 SAID THAT THIS IS GOING TO 6203 04:08:44,878 --> 04:08:46,747 HAPPEN, SO HE'S DEFINITELY ON 6204 04:08:46,747 --> 04:08:47,848 OUR SIDE HERE. 6205 04:08:47,848 --> 04:08:49,550 >> I MEAN, I'D LOVE TO HEAR WHAT 6206 04:08:49,550 --> 04:08:50,284 OTHER COUNCIL MEMBERS HAVE TO 6207 04:08:50,284 --> 04:08:53,387 SAY BUT I THINK YOU NEED TO LET 6208 04:08:53,387 --> 04:08:54,622 HIM KNOW THAT -- WE ALL PROBLEM 6209 04:08:54,622 --> 04:08:59,326 HEAL FEEL THE -- PROBABLY FEEL 6210 04:08:59,326 --> 04:09:02,563 THE WAY WE FEEL BUT I'D LOVE TO 6211 04:09:02,563 --> 04:09:03,297 HEAR WHAT OTHER COUNCIL MEMBERS 6212 04:09:03,297 --> 04:09:04,031 HAVE TO SAY. 6213 04:09:04,031 --> 04:09:07,768 >> I'M TOTALLY WITH YOU ON THIS, 6214 04:09:07,768 --> 04:09:08,135 HANK. 6215 04:09:08,135 --> 04:09:09,536 WALTER, WE WANT TO HELP YOU IN 6216 04:09:09,536 --> 04:09:10,804 ANY WAY WE CAN. 6217 04:09:10,804 --> 04:09:15,676 SO IF THAT'S A LETTER OR 6218 04:09:15,676 --> 04:09:20,314 ANYTHING OTHER THAN THAT, I'M 6219 04:09:20,314 --> 04:09:23,017 OPEN TO SUGGESTIONS. 6220 04:09:23,017 --> 04:09:27,087 >> OR EVEN PASSING A MOTION OF 6221 04:09:27,087 --> 04:09:32,726 SOME SORT TODAY FROM THE BOARD 6222 04:09:32,726 --> 04:09:35,796 OF COUNSELORS SUPPORTING 6223 04:09:35,796 --> 04:09:37,131 REINSTATEMENTS. 6224 04:09:37,131 --> 04:09:38,932 >> THAT'S AN INTERESTING IDEA. 6225 04:09:38,932 --> 04:09:40,334 I WOULD SUPPORT THAT, 6226 04:09:40,334 --> 04:09:40,834 ABSOLUTELY. 6227 04:09:40,834 --> 04:09:43,070 AND WE CAN GET IT INTO LIKE THE 6228 04:09:43,070 --> 04:09:43,303 MINUTES. 6229 04:09:43,303 --> 04:09:46,240 IT SOUNDS LIKE THEY ARE GOING TO 6230 04:09:46,240 --> 04:09:49,009 BE REINSTATED, SO WE HAVE TO BE 6231 04:09:49,009 --> 04:09:50,644 CAUTIOUS ABOUT IF WE NEED A 6232 04:09:50,644 --> 04:09:54,682 LETTER FOR SOMETHING ELSE TOO. 6233 04:09:54,682 --> 04:10:01,822 BUT I DO THINK WE HAVE TO SHOW 6234 04:10:01,822 --> 04:10:02,556 SOLIDARITY HERE. 6235 04:10:02,556 --> 04:10:04,224 >> YEAH, I REALIZE I'M NOT 6236 04:10:04,224 --> 04:10:06,794 ALLOWED TO VOTE BUT I KNOW I'M 6237 04:10:06,794 --> 04:10:09,029 ALLOWED TO EXPRESS FEELINGS. 6238 04:10:09,029 --> 04:10:10,597 ALSO, I'M TERRIBLY CONCERNED 6239 04:10:10,597 --> 04:10:11,065 ABOUT IT. 6240 04:10:11,065 --> 04:10:14,268 AND I THINK I LOVE THAT IDEA OF 6241 04:10:14,268 --> 04:10:17,705 A MOTION BECAUSE I THINK THAT 6242 04:10:17,705 --> 04:10:19,039 WILL SHOW SUPPORT, IF THE 6243 04:10:19,039 --> 04:10:19,640 DIRECTORS ALREADY GOT THIS IN 6244 04:10:19,640 --> 04:10:21,709 MOTION, IT WOULD BE NICE TO SHOW 6245 04:10:21,709 --> 04:10:24,011 THAT WE APPRECIATE THAT AND WE 6246 04:10:24,011 --> 04:10:26,080 FULLY SUPPORT IN A VERY STRONG 6247 04:10:26,080 --> 04:10:27,247 WAY TO MOVE THAT FORWARD. 6248 04:10:27,247 --> 04:10:29,850 >> MAYBE THE WAY WE DO THIS 6249 04:10:29,850 --> 04:10:30,751 BECAUSE I'M HEARING LOTS OF 6250 04:10:30,751 --> 04:10:34,088 SUPPORT AND I DO IT WE'LL HEAR 6251 04:10:34,088 --> 04:10:37,057 ANYTHING OPPOSED THAT IF WE CAN 6252 04:10:37,057 --> 04:10:39,426 GET UNANIMOUS STATEMENT FROM THE 6253 04:10:39,426 --> 04:10:43,097 COUNCIL THAT WE ARE UP COURAGED 6254 04:10:43,097 --> 04:10:44,698 COURAGED -- ENCOURAGED TO HEAR 6255 04:10:44,698 --> 04:10:46,934 THEY WILL BE REINSTATED BY JUNE 6256 04:10:46,934 --> 04:10:48,335 2, IMPERATIVE, MAYBE NOT A 6257 04:10:48,335 --> 04:10:51,371 MOTION BUT IF WALTER COULD GO 6258 04:10:51,371 --> 04:10:53,474 FOR WARD TO THAT STATEMENT BY 6259 04:10:53,474 --> 04:10:56,310 DR. BHATTACHARYA AND MAKE IT 6260 04:10:56,310 --> 04:11:01,081 CLEAR THIS IS CRITICALLY 6261 04:11:01,081 --> 04:11:01,348 IMPORTANT. 6262 04:11:01,348 --> 04:11:02,983 >> I MEAN, I COULD DO THAT OR 6263 04:11:02,983 --> 04:11:07,488 YOU GUYS COULD DO A LETTER, BUT 6264 04:11:07,488 --> 04:11:12,192 WHATEVER YOU FEEL IS GETTING THE 6265 04:11:12,192 --> 04:11:13,060 MESSAGE ACROSS, YEAH. 6266 04:11:13,060 --> 04:11:14,261 >> WHY DON'T WE MAKE A MOTION 6267 04:11:14,261 --> 04:11:17,564 AND THEN HAVE A VOTE ON THIS AND 6268 04:11:17,564 --> 04:11:19,099 WE'LL SEE HOW THIS GOES. 6269 04:11:19,099 --> 04:11:19,800 >> YEAH. 6270 04:11:19,800 --> 04:11:22,302 >> I WILL TRY TO MAKE THIS 6271 04:11:22,302 --> 04:11:23,804 MOTION. 6272 04:11:23,804 --> 04:11:25,372 I MOVE THAT WE AS COUNCIL 6273 04:11:25,372 --> 04:11:28,075 EXPRESS OUR STRONG SUPPORT FOR 6274 04:11:28,075 --> 04:11:33,580 THE RESTORATION OF THE 6275 04:11:33,580 --> 04:11:36,283 SCIENTISTS WHO WERE ERRONEOUSLY 6276 04:11:36,283 --> 04:11:38,819 DISMISSED OR RIF'ed, BECAUSE 6277 04:11:38,819 --> 04:11:40,220 THEIR RESTORATION IS ESSENTIAL 6278 04:11:40,220 --> 04:11:42,222 TO THE VITALITY OF SCIENCE IN 6279 04:11:42,222 --> 04:11:43,490 THE INTRAMURAL BRANCH AND 6280 04:11:43,490 --> 04:11:46,326 ADVANCEMENT OF OUR UNDERSTANDING 6281 04:11:46,326 --> 04:11:48,061 OF BRAIN HEALTH AND ERADICATING 6282 04:11:48,061 --> 04:11:50,230 CHRONIC DISEASE. 6283 04:11:50,230 --> 04:11:55,102 THAT'S THE MOTION. 6284 04:11:55,102 --> 04:11:56,236 >> I SECOND. 6285 04:11:56,236 --> 04:11:57,404 >> SECOND. 6286 04:11:57,404 --> 04:12:00,808 >> ANYONE OPPOSED? 6287 04:12:00,808 --> 04:12:01,909 WE HAVE A UNANIMOUS MOTION. 6288 04:12:01,909 --> 04:12:08,215 AND I DON'T KNOW IF THAT WAS 6289 04:12:08,215 --> 04:12:10,117 RECORDED. 6290 04:12:10,117 --> 04:12:12,219 YOU KNOW THE SENTIMENTS, WALTER, 6291 04:12:12,219 --> 04:12:14,121 SO YOU CAN CARRY THAT FORWARD TO 6292 04:12:14,121 --> 04:12:14,922 DR. BHATTACHARYA. 6293 04:12:14,922 --> 04:12:16,690 >> THANK YOU. 6294 04:12:16,690 --> 04:12:19,626 >> I REALLY APPRECIATE THAT. 6295 04:12:19,626 --> 04:12:21,061 I APPRECIATE THE SENTIMENT AND 6296 04:12:21,061 --> 04:12:22,563 THE MOTION. 6297 04:12:22,563 --> 04:12:26,066 I WILL TELL YOU THAT THE SUPPORT 6298 04:12:26,066 --> 04:12:30,437 OF COUNCIL IS REALLY IMPORTANT. 6299 04:12:30,437 --> 04:12:32,973 AND TO BE FRANK, I DON'T THINK 6300 04:12:32,973 --> 04:12:36,176 THIS IS THE LAST TIME WE'RE 6301 04:12:36,176 --> 04:12:39,580 GOING TO NEED IT. 6302 04:12:39,580 --> 04:12:42,249 WE HAVE SOME EXTREMELY 6303 04:12:42,249 --> 04:12:43,917 CHALLENGING TIMES COMING UP. 6304 04:12:43,917 --> 04:12:47,554 I'M VERY COGNIZANT THOSE 6305 04:12:47,554 --> 04:12:49,423 CHALLENGES ARE NOT RESTRICTED TO 6306 04:12:49,423 --> 04:12:50,791 THE INTRAMURAL PROGRAM. 6307 04:12:50,791 --> 04:12:53,961 THE CHALLENGES FACING THE 6308 04:12:53,961 --> 04:12:54,795 EXTRAMURAL PROGRAM. 6309 04:12:54,795 --> 04:13:01,068 AND THE OFFICE OF DIRECTOR. 6310 04:13:01,068 --> 04:13:03,604 THEY ARE EXISTENTIAL. 6311 04:13:03,604 --> 04:13:05,706 BUT IT MEANS A LOT TO HEAR THE 6312 04:13:05,706 --> 04:13:07,174 SUPPORT FROM THE COUNCIL. 6313 04:13:07,174 --> 04:13:07,674 THANK YOU VERY MUCH. 6314 04:13:07,674 --> 04:13:09,309 >> THE LEAST WE CAN DO. 6315 04:13:09,309 --> 04:13:12,212 THANK YOU. 6316 04:13:12,212 --> 04:13:18,986 >> THANK YOU. 6317 04:13:18,986 --> 04:13:19,119 6318 04:13:19,119 --> 04:13:19,253 6319 04:13:19,253 --> 04:13:25,559 >> ANY OTHER QUESTIONS ABOUT -- 6320 04:13:25,559 --> 04:13:26,260 >> OKAY. 6321 04:13:26,260 --> 04:13:28,729 IF THERE ARE NO OTHER QUESTIONS, 6322 04:13:28,729 --> 04:13:31,398 THANK YOU, JEFF. 6323 04:13:31,398 --> 04:13:34,968 AND THANK YOU, COUNCIL. 6324 04:13:34,968 --> 04:13:35,736 WE APPRECIATE THAT. 6325 04:13:35,736 --> 04:13:39,106 NEXT UP WE HAVE THE "HEAL" PAIN 6326 04:13:39,106 --> 04:13:39,706 STRATEGIC RESEARCH PRIORITIES 6327 04:13:39,706 --> 04:13:40,674 WORKING GROUP. 6328 04:13:40,674 --> 04:13:49,049 AND I'LL TURN IT OVER TO WALTER. 6329 04:13:49,049 --> 04:13:49,349 >> GREAT. 6330 04:13:49,349 --> 04:13:51,351 ROB AND KATHY, ARE YOU LIVE OVER 6331 04:13:51,351 --> 04:13:51,818 THERE SOMEWHERE? 6332 04:13:51,818 --> 04:13:54,655 >> I'M HERE. 6333 04:13:54,655 --> 04:13:54,988 >> AWESOME. 6334 04:13:54,988 --> 04:13:55,522 GREAT. 6335 04:13:55,522 --> 04:13:55,722 OKAY. 6336 04:13:55,722 --> 04:13:57,190 WE'RE GOING TO HEAR A REPORT 6337 04:13:57,190 --> 04:13:59,626 FROM THE HEAL PAIN STRATEGIC 6338 04:13:59,626 --> 04:14:00,594 RESEARCH PRIORITIES WORKING 6339 04:14:00,594 --> 04:14:00,794 GROUP. 6340 04:14:00,794 --> 04:14:08,235 AND IT'S GOING TO BE BY ROB ROB 6341 04:14:08,235 --> 04:14:09,469 GEREAU, AND KATHLEEN SLUKA, 6342 04:14:09,469 --> 04:14:11,805 WORKING TOGETHER A YEAR PUTTING 6343 04:14:11,805 --> 04:14:12,306 TOGETHER RESEARCH 6344 04:14:12,306 --> 04:14:14,174 RECOMMENDATIONS FOR THE PAIN 6345 04:14:14,174 --> 04:14:18,312 SIDE OF THE HEAL INITIATIVE, WE 6346 04:14:18,312 --> 04:14:19,446 CALL IT THE CONGRESS 6347 04:14:19,446 --> 04:14:21,515 APPROPRIATED $285 MILLION A YEAR 6348 04:14:21,515 --> 04:14:27,955 TO NINDS, THESE FUNDS ARE THEN 6349 04:14:27,955 --> 04:14:30,958 PUT INTO RESEARCH THAT IS VOTED 6350 04:14:30,958 --> 04:14:36,196 ON BY 14 I.C. DIRECTORS, PART OF 6351 04:14:36,196 --> 04:14:38,098 THE HEAL-PAIN I.C. DIRECTOR 6352 04:14:38,098 --> 04:14:39,266 GROUP. 6353 04:14:39,266 --> 04:14:42,536 WE HAVE STEERING COMMITTEE 6354 04:14:42,536 --> 04:14:45,172 MEMBERS, WHO ARE FROM THE 6355 04:14:45,172 --> 04:14:48,175 PROGRAM DIRECTORS OF ALL 14 6356 04:14:48,175 --> 04:14:50,711 INSTITUTES, IT'S A REALLY 6357 04:14:50,711 --> 04:14:52,512 TRANS-NIH ACTIVITY BECAUSE PAIN 6358 04:14:52,512 --> 04:14:55,615 IS SOMETHING THAT'S REALLY IN 6359 04:14:55,615 --> 04:14:56,750 THE PORTFOLIO OF THE 14 6360 04:14:56,750 --> 04:15:00,754 DIFFERENT I.C.s, SO IT'S BEEN 6361 04:15:00,754 --> 04:15:03,423 A GREAT PROGRAM. 6362 04:15:03,423 --> 04:15:06,093 IT WAS STARTED BY DR. COLLINS IN 6363 04:15:06,093 --> 04:15:13,734 RESPONSE TO THE OPIOID CRISIS, A 6364 04:15:13,734 --> 04:15:18,405 LARGE COMPONENT RUN BY DRUG 6365 04:15:18,405 --> 04:15:18,972 ABUSE AND NORA VOLKOW, $385 6366 04:15:18,972 --> 04:15:20,207 MILLION A YEAR IN THE HEAL 6367 04:15:20,207 --> 04:15:24,211 INITIATIVE AND WE DO JOINT 6368 04:15:24,211 --> 04:15:26,446 PROGRAMS WITH THEM PARTICULARLY 6369 04:15:26,446 --> 04:15:29,916 REGARDING THE OVERLAP BETWEEN 6370 04:15:29,916 --> 04:15:32,119 PAIN AND OPIOID OVERUSE AND 6371 04:15:32,119 --> 04:15:34,221 INTERESTING PROGRAMS, ONE BEING 6372 04:15:34,221 --> 04:15:39,159 THE N-CREW PROGRAM TO TRY TO 6373 04:15:39,159 --> 04:15:40,327 IMPROVE PAIN MANAGEMENT AND 6374 04:15:40,327 --> 04:15:43,530 REDUCE OPIOID DEATHS IN NATIVE 6375 04:15:43,530 --> 04:15:44,264 AMERICAN POPULATIONS, MANY 6376 04:15:44,264 --> 04:15:46,800 OTHERS AS WELL. 6377 04:15:46,800 --> 04:15:48,869 WE'VE NOT HAD A STRATEGIC 6378 04:15:48,869 --> 04:15:50,037 RESEARCH PRIORITY WORKING GROUP 6379 04:15:50,037 --> 04:15:51,605 LOOKING AT "HEAL," IN THE PAST, 6380 04:15:51,605 --> 04:15:54,274 IT WAS REALLY THE BRAINCHILD OF 6381 04:15:54,274 --> 04:15:56,543 DR. COLLINS TO BEGIN WITH. 6382 04:15:56,543 --> 04:15:58,578 BUT THE GROUP THAT WAS PUT 6383 04:15:58,578 --> 04:16:03,083 TOGETHER ABOUT A YEAR AGO DID A 6384 04:16:03,083 --> 04:16:05,485 FANTASTIC JOB, I'M LOOKING 6385 04:16:05,485 --> 04:16:08,121 FORWARD TO THE REPORT BY ROB AND 6386 04:16:08,121 --> 04:16:08,822 KATHLEEN. 6387 04:16:08,822 --> 04:16:10,857 ROB IS DIRECTOR OF WASHINGTON 6388 04:16:10,857 --> 04:16:12,192 UNIVERSITY PAIN CENTER, AND HE'S 6389 04:16:12,192 --> 04:16:14,294 IN THE DEPARTMENT OF ANESTHESIA. 6390 04:16:14,294 --> 04:16:17,764 HIS WORK FOCUSES ON DETERMINING 6391 04:16:17,764 --> 04:16:19,266 CIRCUITS, CELLULAR AND MOW 6392 04:16:19,266 --> 04:16:21,601 ELECTRIC MAR MECHANISMS IN 6393 04:16:21,601 --> 04:16:22,536 DEVELOPMENT CHRONIC PAIN 6394 04:16:22,536 --> 04:16:25,172 CONDITIONS WITH AN EYE TOWARD 6395 04:16:25,172 --> 04:16:26,206 INFORMING DEVELOPMENT OF NEW 6396 04:16:26,206 --> 04:16:30,777 APPROACHES FOR PREVENTION AND 6397 04:16:30,777 --> 04:16:31,711 MANAGEMENT. 6398 04:16:31,711 --> 04:16:34,414 HE RECEIVED THE NINDS LANDIS 6399 04:16:34,414 --> 04:16:36,216 AWARD FOR OUTSTANDING MENTORSHIP 6400 04:16:36,216 --> 04:16:37,284 IN 2020. 6401 04:16:37,284 --> 04:16:39,586 KATHLEEN IS PROFESSOR OF 6402 04:16:39,586 --> 04:16:40,487 PHYSICAL THERAPY AND REHAB, 6403 04:16:40,487 --> 04:16:42,389 UNIVERSITY OF IOWA, HER WORK 6404 04:16:42,389 --> 04:16:44,624 FOCUSES ON PERIPHERAL AND 6405 04:16:44,624 --> 04:16:47,327 CENTRAL MECHANISMS OF CHRONIC 6406 04:16:47,327 --> 04:16:49,830 MUSCULOSKELETAL PAIN AND 6407 04:16:49,830 --> 04:16:50,430 NON-PHARMACOLOGICAL TREATMENTS 6408 04:16:50,430 --> 04:16:51,164 FOR CHRONIC PAIN, P.I. OF A 6409 04:16:51,164 --> 04:16:52,766 NUMBER OF NIH AND HEAL AWARDS 6410 04:16:52,766 --> 04:16:55,335 AND INCLUDING THE P.I. OF THE 6411 04:16:55,335 --> 04:16:56,536 CLINICAL COORDINATING CENTER FOR 6412 04:16:56,536 --> 04:16:59,239 THE ACUTE TO CHRONIC PAIN 6413 04:16:59,239 --> 04:17:03,844 SIGNATURE PROGRAM AND CO-P.I. ON 6414 04:17:03,844 --> 04:17:04,811 THE IOWA T32 INTERDISCIPLINARY 6415 04:17:04,811 --> 04:17:08,014 TRAINING PROGRAM IN PAIN, ALSO 6416 04:17:08,014 --> 04:17:15,689 RECIPIENT OF THE 2024 "HEAL" 6417 04:17:15,689 --> 04:17:16,223 MENTORSHIP AWARD. 6418 04:17:16,223 --> 04:17:19,192 ROB WILL START, IS THAT RIGHT? 6419 04:17:19,192 --> 04:17:19,559 >> YEAH. 6420 04:17:19,559 --> 04:17:21,928 THANK YOU, WALTER. 6421 04:17:21,928 --> 04:17:22,896 WELCOME TO EVERYBODY. 6422 04:17:22,896 --> 04:17:25,966 HANG IN THERE, IT'S BEEN A LONG 6423 04:17:25,966 --> 04:17:27,067 RUN HERE. 6424 04:17:27,067 --> 04:17:28,301 WE'RE GOING TO SPEAK ABOUT 6425 04:17:28,301 --> 04:17:30,170 SOMETHING MORE POSITIVE IN TERMS 6426 04:17:30,170 --> 04:17:32,539 OF DEVELOPING NEW RESEARCH 6427 04:17:32,539 --> 04:17:33,673 STRATEGIES AROUND PAIN FOR NINDS 6428 04:17:33,673 --> 04:17:35,075 TO CONSIDER IN THE CONTEXT OF 6429 04:17:35,075 --> 04:17:38,211 THE HEAL INITIATIVE. 6430 04:17:38,211 --> 04:17:39,779 PRESENTING ON THE FIRST HALF 6431 04:17:39,779 --> 04:17:44,851 WITH KATHLEEN, I DO ALSO WANT TO 6432 04:17:44,851 --> 04:17:47,120 MENTION OUR INCREDIBLE PARTNER 6433 04:17:47,120 --> 04:17:49,556 IN THIS, JACKIE WARD, WHO WAS 6434 04:17:49,556 --> 04:17:51,191 THE DESIGNATED OFFICIAL TO WORK 6435 04:17:51,191 --> 04:17:54,194 WITH US AS PART OF THIS PROCESS 6436 04:17:54,194 --> 04:17:57,297 WHO WAS UNFORTUNATELY LOST FROM 6437 04:17:57,297 --> 04:17:58,865 NINDS WITH THE SORT OF 6438 04:17:58,865 --> 04:18:00,233 DEVASTATING TO THE PAIN RESEARCH 6439 04:18:00,233 --> 04:18:01,034 COMMUNITY LOSS OF THE ENTIRE 6440 04:18:01,034 --> 04:18:04,871 OFFICE OF PAIN POLICY AND 6441 04:18:04,871 --> 04:18:05,138 PLANNING. 6442 04:18:05,138 --> 04:18:07,307 AND JUST TO MARK THIS MOMENT TO 6443 04:18:07,307 --> 04:18:08,808 THANK THEM FOR THE INCREDIBLE 6444 04:18:08,808 --> 04:18:11,311 WORK THAT GROUP HAS DONE OVER 6445 04:18:11,311 --> 04:18:16,850 THE YEARS, AND WE CERTAINLY MISS 6446 04:18:16,850 --> 04:18:18,185 THEM. 6447 04:18:18,185 --> 04:18:21,755 NEXT SLIDE PLEASE. 6448 04:18:21,755 --> 04:18:23,423 WALTER MENTIONED THE HEAL 6449 04:18:23,423 --> 04:18:25,058 INITIATIVE, LAUNCHED IN 2018, TO 6450 04:18:25,058 --> 04:18:27,027 SET THE TABLE HERE, AFTER 6451 04:18:27,027 --> 04:18:27,994 CONGRESS ADDED THIS $500 MILLION 6452 04:18:27,994 --> 04:18:29,563 TO THE BASE APPROPRIATION FOR 6453 04:18:29,563 --> 04:18:33,700 NIH TO DEVELOP NEW INITIATIVE TO 6454 04:18:33,700 --> 04:18:35,368 RESEARCH OPIOID ADDICTION, 6455 04:18:35,368 --> 04:18:39,339 ALTERNATIVES, PAIN MANAGEMENT, 6456 04:18:39,339 --> 04:18:40,874 ADDICTION TREATMENT. 6457 04:18:40,874 --> 04:18:44,945 THIS WAS LAUNCHED AT BREAK-NECK 6458 04:18:44,945 --> 04:18:45,145 SPEED. 6459 04:18:45,145 --> 04:18:47,847 AND THERE WAS NO TIME AT THE 6460 04:18:47,847 --> 04:18:50,383 BEGINNING TO UNDERGO A FORMAL 6461 04:18:50,383 --> 04:18:53,119 STRATEGIC PLANNING PROCESS. 6462 04:18:53,119 --> 04:18:54,521 FORTUNATELY THERE HAD BEEN 6463 04:18:54,521 --> 04:18:59,492 RECENTLY DEVELOPMENT OF FEDERAL 6464 04:18:59,492 --> 04:19:02,295 PAIN RESEARCH STRATEGY IN 2017, 6465 04:19:02,295 --> 04:19:04,130 AND THEN ADDITIONAL INFORMATION 6466 04:19:04,130 --> 04:19:06,499 GARNERED THROUGH THE SERIES OF 6467 04:19:06,499 --> 04:19:08,001 THIS WAS CALLED CUTTING EDGE 6468 04:19:08,001 --> 04:19:10,737 SCIENCE MEETING TO END THE 6469 04:19:10,737 --> 04:19:12,205 OPIOID CRISIS THAT WERE CONVENED 6470 04:19:12,205 --> 04:19:14,241 TO TALK ABOUT BOTH PAIN AND 6471 04:19:14,241 --> 04:19:16,676 OPIOID ADDICTION AT THAT TIME. 6472 04:19:16,676 --> 04:19:18,378 SO, WHAT WAS DONE AT THAT TIME 6473 04:19:18,378 --> 04:19:23,450 WAS INFORMATION SORT OF FROM 6474 04:19:23,450 --> 04:19:25,118 THOSE PROCESSES WAS MINED TO 6475 04:19:25,118 --> 04:19:26,620 DEVELOP A HEAL RESEARCH STRATEGY 6476 04:19:26,620 --> 04:19:28,421 THAT WAS PUBLISHED IN JAMA, AND 6477 04:19:28,421 --> 04:19:33,593 THAT WAS USED TO DEVELOP THE 6478 04:19:33,593 --> 04:19:34,261 INITIAL SET OF FUNDING 6479 04:19:34,261 --> 04:19:36,062 OPPORTUNITY ANNOUNCEMENTS THAT 6480 04:19:36,062 --> 04:19:37,097 FORMED THE BASIS FOR PAIN 6481 04:19:37,097 --> 04:19:38,832 RESEARCH AND FOR "HEAL." 6482 04:19:38,832 --> 04:19:40,967 SO FROM 2018 TO 2023, THE HEAL 6483 04:19:40,967 --> 04:19:44,704 INITIATIVE WAS HOUSED IN THE 6484 04:19:44,704 --> 04:19:45,905 OFFICE OF THE DIRECTOR. 6485 04:19:45,905 --> 04:19:48,308 AND THEREAFTER AS WALTER 6486 04:19:48,308 --> 04:19:50,877 MENTIONED IT'S BEEN HOSTED 6487 04:19:50,877 --> 04:19:53,513 JOINTLY THROUGH NIDA AND DR. 6488 04:19:53,513 --> 04:19:59,185 COAL -- 6489 04:19:59,185 --> 04:20:03,156 DR. VOLKOW AND NINDS WITH DR. 6490 04:20:03,156 --> 04:20:03,690 KOROSHETZ. 6491 04:20:03,690 --> 04:20:04,658 JEFF MENTIONED THAT. 6492 04:20:04,658 --> 04:20:07,927 SINCE ITS BEGINNING AS YOU CAN 6493 04:20:07,927 --> 04:20:09,696 SEE HERE OVER 2200 RESEARCH 6494 04:20:09,696 --> 04:20:12,098 PROJECTS HAVE BEEN INITIATED, 6495 04:20:12,098 --> 04:20:16,002 ALL 50 STATES, INCLUDING 6496 04:20:16,002 --> 04:20:18,071 TOTALING $3.9 BILLION IN TOTAL 6497 04:20:18,071 --> 04:20:18,371 INVESTMENT. 6498 04:20:18,371 --> 04:20:19,939 AS WALTER SAID A COLLABORATION 6499 04:20:19,939 --> 04:20:30,417 ACROSS ALL 19 ICs, IT'S BEEN 6500 04:20:31,651 --> 04:20:32,652 PRODUCTIVE, OVER 40 FDA 6501 04:20:32,652 --> 04:20:35,288 APPROVALS FOR DRUGS AND DEVICES, 6502 04:20:35,288 --> 04:20:37,924 300 CLINICAL TRIALS UNDERWAY OR 6503 04:20:37,924 --> 04:20:38,391 JUST FINISHING. 6504 04:20:38,391 --> 04:20:43,897 SO, MANY OF THOSE INITIAL 6505 04:20:43,897 --> 04:20:46,032 PROJECTS FROM THAT HEAL 1.0 ARE 6506 04:20:46,032 --> 04:20:48,234 WRAPPING UP NOW, TRANSITION 6507 04:20:48,234 --> 04:20:52,505 POINT, AS I SAY. 6508 04:20:52,505 --> 04:20:58,311 AND RECENTLY THE LAST YEAR THE 6509 04:20:58,311 --> 04:21:00,914 HEAL MULTI-DISCIPLINARY GROUP 6510 04:21:00,914 --> 04:21:03,483 WHICH I'M A MEMBER OF DEVELOPED 6511 04:21:03,483 --> 04:21:06,486 A STRATEGIC PLAN TO GUIDE 6512 04:21:06,486 --> 04:21:08,154 INVESTMENTS AROUND PAIN. 6513 04:21:08,154 --> 04:21:10,857 AND SO THIS WAS SUPPOSED TO BE A 6514 04:21:10,857 --> 04:21:12,726 DELIBERATIVE PROCESS GUIDED BY 6515 04:21:12,726 --> 04:21:14,861 EXTERNAL WORKING GROUP TO 6516 04:21:14,861 --> 04:21:15,462 RECOMMEND STRATEGIC RESEARCH 6517 04:21:15,462 --> 04:21:18,798 PRIORITIES THAT CAN FORM BASIS 6518 04:21:18,798 --> 04:21:20,300 FOR THE NEXT FEW YEARS OF THE 6519 04:21:20,300 --> 04:21:23,536 HEAL INITIATIVE. 6520 04:21:23,536 --> 04:21:23,937 NEXT SLIDE PLEASE. 6521 04:21:23,937 --> 04:21:26,239 SO, AS PART OF THIS WHEN WE 6522 04:21:26,239 --> 04:21:27,707 BEGAN THIS PROCESS ONE OF THE 6523 04:21:27,707 --> 04:21:31,311 THINGS WE ASKED FOR WAS AN 6524 04:21:31,311 --> 04:21:33,713 ANALYSIS OF PAIN RESEARCH AT THE 6525 04:21:33,713 --> 04:21:36,716 NIH AND HOW THINGS HAVE BEEN 6526 04:21:36,716 --> 04:21:37,717 TRENDING OVER TIME SINCE THE 6527 04:21:37,717 --> 04:21:40,286 ADDITION OF THE HEAL INITIATIVE. 6528 04:21:40,286 --> 04:21:42,455 IT'S REALLY IMPORTANT TO NOTE 6529 04:21:42,455 --> 04:21:43,790 THAT FUNDING UNDER HEAL 6530 04:21:43,790 --> 04:21:45,725 INITIATIVE IS NOT MEANT TO 6531 04:21:45,725 --> 04:21:48,094 COMPRISE ALL OF PAIN RESEARCH AT 6532 04:21:48,094 --> 04:21:48,828 THE NIH. 6533 04:21:48,828 --> 04:21:50,597 IT'S VERY SPECIFIC. 6534 04:21:50,597 --> 04:21:52,999 THERE'S THE HEAL PAIN MISSION 6535 04:21:52,999 --> 04:21:54,200 STATEMENT IS HERE. 6536 04:21:54,200 --> 04:21:56,002 IT ENDS TO REDUCE PAIN AND RISK 6537 04:21:56,002 --> 04:21:57,837 OF OPIOID USE DISORDER BY 6538 04:21:57,837 --> 04:21:59,038 DEVELOPING SAFE AND EFFECTIVE 6539 04:21:59,038 --> 04:22:01,207 PAIN TREATMENT AND PREVENTION 6540 04:22:01,207 --> 04:22:02,842 STRATEGIES TO IMPROVE QUALITY OF 6541 04:22:02,842 --> 04:22:11,384 LIFE FOR ALL PEOPLE, A SET 6542 04:22:11,384 --> 04:22:14,487 CIRCUMSCRIBED GOALS, A SMART 6543 04:22:14,487 --> 04:22:16,723 PART OF RESEARCH ACTIVITY AT THE 6544 04:22:16,723 --> 04:22:16,956 NIH. 6545 04:22:16,956 --> 04:22:21,194 YOU CAN SEE ON THE GRAPH THE NIH 6546 04:22:21,194 --> 04:22:21,828 FUNDING FOR PAIN-RELATED 6547 04:22:21,828 --> 04:22:24,230 RESEARCH OVER TIME. 6548 04:22:24,230 --> 04:22:32,138 AND YOU CAN SEE WITH THE TEALISH 6549 04:22:32,138 --> 04:22:34,607 BARS, YOU CAN SEE FUNDING IN 6550 04:22:34,607 --> 04:22:37,043 2018 ARE THAT FIRST COUPLE YEARS 6551 04:22:37,043 --> 04:22:38,445 WAS LUMPED AND SPLIT OVER 2018 6552 04:22:38,445 --> 04:22:38,978 AND 2019. 6553 04:22:38,978 --> 04:22:44,217 BUT YOU CAN SEE THAT THE GENERAL 6554 04:22:44,217 --> 04:22:48,388 NIH IC FUNDING FOR PAIN RESEARCH 6555 04:22:48,388 --> 04:22:51,691 SHOWN IN THE PINKISH BARS 6556 04:22:51,691 --> 04:22:55,261 CONTINUED TO TREND UP, AND THAT 6557 04:22:55,261 --> 04:22:57,530 TREND UPWARD TRACKS NICELY WITH 6558 04:22:57,530 --> 04:22:58,364 THE TOTAL NIH BUDGET. 6559 04:22:58,364 --> 04:23:04,370 SO THAT'S JUST TO SAY THAT THE 6560 04:23:04,370 --> 04:23:06,339 I.C. FUNDING FOR PAIN RESEARCH, 6561 04:23:06,339 --> 04:23:07,407 THEY DIDN'T TAKE THE FOOT OFF 6562 04:23:07,407 --> 04:23:10,109 THE GAS IN TERMS OF FUNDING 6563 04:23:10,109 --> 04:23:11,945 BASIC PAIN RESEARCH. 6564 04:23:11,945 --> 04:23:12,979 THIS WAS ADDITIONAL FUNDING 6565 04:23:12,979 --> 04:23:14,113 FOCUSED ON THIS MISSION AND THAT 6566 04:23:14,113 --> 04:23:17,083 GOAL, THE GOAL OF COURSE WAS TO 6567 04:23:17,083 --> 04:23:19,285 ACCELERATE DEVELOPMENT OF 6568 04:23:19,285 --> 04:23:20,587 TREATMENTS, IT'S VERY EVIDENT 6569 04:23:20,587 --> 04:23:22,889 FROM THE ANALYSIS THIS WAS 6570 04:23:22,889 --> 04:23:23,456 ADDITIONAL FUNDING AND I'LL 6571 04:23:23,456 --> 04:23:24,991 DESCRIBE SOME OF THE WORK THAT'S 6572 04:23:24,991 --> 04:23:27,227 HAPPENED AND YOU CAN SEE IT'S 6573 04:23:27,227 --> 04:23:32,031 REALLY MADE A DIFFERENCE IN THIS 6574 04:23:32,031 --> 04:23:32,265 PROCESS. 6575 04:23:32,265 --> 04:23:36,069 THANK YOU. 6576 04:23:36,069 --> 04:23:40,173 NEXT SLIDE PLEASE. 6577 04:23:40,173 --> 04:23:41,808 YOU CAN READ THROUGH THIS. 6578 04:23:41,808 --> 04:23:43,910 ONE OF THE BIG ACHIEVEMENTS AT 6579 04:23:43,910 --> 04:23:46,079 THE BEGINNING IN THE FIRST PHASE 6580 04:23:46,079 --> 04:23:47,780 WAS ESTABLISHMENT OF AN 6581 04:23:47,780 --> 04:23:48,815 ECOSYSTEM THAT ENABLED 6582 04:23:48,815 --> 04:23:50,783 DEVELOPMENT OF THERAPEUTICS IN 6583 04:23:50,783 --> 04:23:53,253 THE CONTEXT OF ACADEMIC SETTING. 6584 04:23:53,253 --> 04:24:02,228 AND SOME OF THAT THERE HAVE BEEN 6585 04:24:02,228 --> 04:24:04,898 VALIDATION OF NON-OPIOID 6586 04:24:04,898 --> 04:24:06,699 TARGETS, INHIBITORS, MODULATORS, 6587 04:24:06,699 --> 04:24:08,535 AND ACETOMENOPHIN ANALOGS WITH 6588 04:24:08,535 --> 04:24:12,972 LOWER RISK OF HEPATOTOXICITY. 6589 04:24:12,972 --> 04:24:15,408 AN INTERESTING STUDY ON MINK 6590 04:24:15,408 --> 04:24:17,343 INHIBITORS THAT'S IN PHASE 1, 6591 04:24:17,343 --> 04:24:18,745 NEAR COMPLETION OF PHASE 1 FOR 6592 04:24:18,745 --> 04:24:19,879 TREATMENT OF PAIN. 6593 04:24:19,879 --> 04:24:21,981 AND A NUMBER OF STUDIES 6594 04:24:21,981 --> 04:24:24,751 RELATESSED TO DEVELOPMENT OF NEW 6595 04:24:24,751 --> 04:24:28,555 CB-1 RECEPTOR MODULATORS. 6596 04:24:28,555 --> 04:24:30,590 THERE'S BEEN WORK UNDERSTANDING 6597 04:24:30,590 --> 04:24:33,960 PAIN BIOLOGY LIKE HUMAN PAIN 6598 04:24:33,960 --> 04:24:35,361 BIOLOGY, IDENTIFYING BIOMARKERS, 6599 04:24:35,361 --> 04:24:40,199 DEVELOPING OF ATLAS OF SENSORY 6600 04:24:40,199 --> 04:24:41,200 NEURONS ACROSS SPECIES, REALTIME 6601 04:24:41,200 --> 04:24:42,302 SIGNATURE FOR CHRONIC PAIN FROM 6602 04:24:42,302 --> 04:24:45,705 PEOPLE WITH CHRONIC PAIN 6603 04:24:45,705 --> 04:24:46,573 DISORDERS. 6604 04:24:46,573 --> 04:24:52,245 BY STROKE OR AMPUTATION. 6605 04:24:52,245 --> 04:24:54,013 IMAGING BIOMARKERS THAT 6606 04:24:54,013 --> 04:24:55,181 DISTINGUISH BETWEEN AGING, 6607 04:24:55,181 --> 04:24:57,317 ADVANCES IN DEVICES FOR PAIN 6608 04:24:57,317 --> 04:24:59,085 MANAGEMENT, IMPROVED FORMS OF 6609 04:24:59,085 --> 04:25:03,323 SPINAL CORD STIMULATION, FOR 6610 04:25:03,323 --> 04:25:03,990 EXAMPLE, NEW TRANSCUTANEOUS 6611 04:25:03,990 --> 04:25:06,359 STIMULATOR FOR TREATMENT OF 6612 04:25:06,359 --> 04:25:06,559 PAIN. 6613 04:25:06,559 --> 04:25:10,163 AND CLEARANCE, FDA CLEARANCE OF 6614 04:25:10,163 --> 04:25:12,932 DEVICE TO TREAT CHRONIC PAIN. 6615 04:25:12,932 --> 04:25:14,400 THERE ARE MORE THAN 40 CLINICAL 6616 04:25:14,400 --> 04:25:16,970 TRIALS, MANY ARE WRAPPING UP 6617 04:25:16,970 --> 04:25:22,241 THIS YEAR, ONE SHOWED BENEFIT TO 6618 04:25:22,241 --> 04:25:23,776 PEOPLE WITH DIALYSIS-RELATED 6619 04:25:23,776 --> 04:25:25,612 PAIN USING COPING SKILLS THAT 6620 04:25:25,612 --> 04:25:26,980 LESSENED INTERFERENCE OF PAIN IN 6621 04:25:26,980 --> 04:25:28,948 THEIR LIVES. 6622 04:25:28,948 --> 04:25:31,351 THERE'S BEEN A HUGE IMPACT FROM 6623 04:25:31,351 --> 04:25:33,119 HEAL INITIATIVE ON PROVIDING 6624 04:25:33,119 --> 04:25:35,521 TRAINING FOR PAIN RESEARCHERS, 6625 04:25:35,521 --> 04:25:38,324 OVER 80 EARLY CAREER RESEARCHERS 6626 04:25:38,324 --> 04:25:39,292 SUPPORTED, ESTABLISHED INITIALLY 6627 04:25:39,292 --> 04:25:40,994 THE PURPOSE NETWORK WHICH HELPS 6628 04:25:40,994 --> 04:25:42,528 CONNECT FOLKS AND CREATED SOME 6629 04:25:42,528 --> 04:25:45,732 RESOURCES THAT WE'RE GOING TO 6630 04:25:45,732 --> 04:25:46,899 TRY TO CONTINUE IN ITS ABSENCE 6631 04:25:46,899 --> 04:25:49,702 GOING FORWARD. 6632 04:25:49,702 --> 04:25:53,773 NEXT SLIDE PLEASE. 6633 04:25:53,773 --> 04:25:56,209 SO HERE'S THE TIMELINE. 6634 04:25:56,209 --> 04:25:58,645 THIS WAS PROPOSED TO DEVELOP 6635 04:25:58,645 --> 04:26:00,046 THIS NEW SET OF RESEARCH 6636 04:26:00,046 --> 04:26:01,014 PRIORITIES, WE STARTED THIS 6637 04:26:01,014 --> 04:26:03,983 PROCESS A LITTLE OVER A YEAR 6638 04:26:03,983 --> 04:26:04,751 AGO. 6639 04:26:04,751 --> 04:26:07,053 THIS WORKING GROUP FORMED AS A 6640 04:26:07,053 --> 04:26:08,888 WORKING GROUP OF THIS COUNCIL, 6641 04:26:08,888 --> 04:26:12,959 LAUNCHED IN LATE APRIL, EARLY 6642 04:26:12,959 --> 04:26:14,093 MAY OF 2024. 6643 04:26:14,093 --> 04:26:15,828 THE FIRST THING THAT WE DID WAS 6644 04:26:15,828 --> 04:26:19,198 TO MAKE SURE THAT THIS WAS AN 6645 04:26:19,198 --> 04:26:22,035 INCLUSIVE PROCESS, ONE THAT GOT 6646 04:26:22,035 --> 04:26:23,870 BROAD STAKEHOLDER INPUTS, THAT 6647 04:26:23,870 --> 04:26:25,738 BEGAN IN JUNE OF 2024 WITH 6648 04:26:25,738 --> 04:26:27,240 REQUEST FOR INFORMATION TO 6649 04:26:27,240 --> 04:26:29,042 SOLICIT INPUT ON THE FUTURE OF 6650 04:26:29,042 --> 04:26:30,343 THE HEAL INITIATIVE, REQUEST WAS 6651 04:26:30,343 --> 04:26:33,079 WHAT HAS "HEAL" DONE WELL, WHAT 6652 04:26:33,079 --> 04:26:34,847 ARE GAPS, WHAT HAS BEEN MISSED, 6653 04:26:34,847 --> 04:26:36,816 WHAT SHOULD BE PRIORITIZED GOING 6654 04:26:36,816 --> 04:26:37,483 FORWARD. 6655 04:26:37,483 --> 04:26:40,820 THAT INFORMATION WE GOT A LOT OF 6656 04:26:40,820 --> 04:26:44,057 RESPONSES ON, INDIVIDUALS FROM 6657 04:26:44,057 --> 04:26:47,860 PATIENTS, FROM PHYSICIANS, FROM 6658 04:26:47,860 --> 04:26:53,466 PATIENT ADVOCACY GROUPS THAT 6659 04:26:53,466 --> 04:26:55,168 HELPED US COALESCE SEVEN 6660 04:26:55,168 --> 04:26:59,906 RESEARCH AREAS, AREAS FOR 6661 04:26:59,906 --> 04:27:01,941 RESEARCH FOCUS, FROM THAT RFI 6662 04:27:01,941 --> 04:27:03,176 THAT WE CONVENED A WORKING GROUP 6663 04:27:03,176 --> 04:27:05,945 AROUND THOSE SEVEN AREAS. 6664 04:27:05,945 --> 04:27:10,850 IN JULY, WE BEGAN A PROCESS 6665 04:27:10,850 --> 04:27:14,253 WHERE THESE SUBCOMMITTEES BEGAN 6666 04:27:14,253 --> 04:27:15,788 MEETING, DELIBERATING, AND EACH 6667 04:27:15,788 --> 04:27:18,658 OF THEM ALSO HAD PUBLIC 6668 04:27:18,658 --> 04:27:19,826 WORKSHOPS, ADDITIONAL REQUESTS 6669 04:27:19,826 --> 04:27:22,695 FOR INFORMATION AROUND THESE 6670 04:27:22,695 --> 04:27:24,664 SPECIFIC AREAS, TO -- I'LL GO 6671 04:27:24,664 --> 04:27:26,432 THROUGH THOSE SPECIFIC AREAS IN 6672 04:27:26,432 --> 04:27:27,100 A MINUTE. 6673 04:27:27,100 --> 04:27:31,537 BUT TO KIND OF HELP THEM INFORM 6674 04:27:31,537 --> 04:27:35,041 THEIR DELIBERATIONS WHICH THAT 6675 04:27:35,041 --> 04:27:35,808 PROCESS, THOSE PUBLIC WORKSHOPS, 6676 04:27:35,808 --> 04:27:38,845 FOUR OR FIVE-HOUR PUBLIC 6677 04:27:38,845 --> 04:27:42,648 WORKSHOPS, ALL THESE THAT WE 6678 04:27:42,648 --> 04:27:43,850 ATTENDED WITH OUR STAFF, THEN 6679 04:27:43,850 --> 04:27:46,452 THEIR CHARGE WAS BY DECEMBER OR 6680 04:27:46,452 --> 04:27:47,954 JANUARY WE WERE MOVING AT 6681 04:27:47,954 --> 04:27:50,957 BREAK-NECK SPEED BECAUSE THE 6682 04:27:50,957 --> 04:27:52,592 GOAL WAS TO WRAP UP BY JANUARY 6683 04:27:52,592 --> 04:27:54,460 TO GET A RECOMMENDATION TO 6684 04:27:54,460 --> 04:27:55,661 COUNCIL IN FEBRUARY TO HELP 6685 04:27:55,661 --> 04:27:57,163 INFORM MAYBE THE DEVELOPMENT OF 6686 04:27:57,163 --> 04:28:00,733 A STRATEGIC PLAN AND POTENTIAL 6687 04:28:00,733 --> 04:28:02,535 FUNDING OPPORTUNITIES FOR FY 27. 6688 04:28:02,535 --> 04:28:09,242 SO, THAT WRAPPED UP IN JANUARY, 6689 04:28:09,242 --> 04:28:10,243 WORKING GROUPS PROVIDED FINAL 6690 04:28:10,243 --> 04:28:11,477 RECOMMENDATIONS TO THE EXECUTIVE 6691 04:28:11,477 --> 04:28:11,911 COMMITTEE. 6692 04:28:11,911 --> 04:28:13,045 WE'LL GO THROUGH THE PROCESS IN 6693 04:28:13,045 --> 04:28:13,946 A LITTLE BIT. 6694 04:28:13,946 --> 04:28:15,915 AND HERE WE ARE TODAY TO TALK 6695 04:28:15,915 --> 04:28:18,885 ABOUT THIS PROCESS. 6696 04:28:18,885 --> 04:28:22,255 NEXT SLIDE PLEASE. 6697 04:28:22,255 --> 04:28:25,024 SO, THIS SHOWS THE EXECUTIVE 6698 04:28:25,024 --> 04:28:27,260 COMMITTEE AND THE SEVEN 6699 04:28:27,260 --> 04:28:31,531 SUBCOMMITTEE CHAIRS, KATHLEEN 6700 04:28:31,531 --> 04:28:32,799 AND MYSELF VERY SKILLFULLY 6701 04:28:32,799 --> 04:28:34,500 HELPED -- LET ME BACK UP A 6702 04:28:34,500 --> 04:28:34,967 LITTLE BIT. 6703 04:28:34,967 --> 04:28:35,835 ONE SLIDE PLEASE. 6704 04:28:35,835 --> 04:28:37,503 THERE WE GO. 6705 04:28:37,503 --> 04:28:40,072 MICHAEL FALCON, OUR LIVED 6706 04:28:40,072 --> 04:28:42,041 EXPERIENCE ADVISER, HELPFUL IN 6707 04:28:42,041 --> 04:28:43,910 INTEGRATING THE VOICE OF THE 6708 04:28:43,910 --> 04:28:45,044 FOLKS WITH LIVED AND LIVING 6709 04:28:45,044 --> 04:28:46,212 EXPERIENCE OF PAIN THROUGHOUT 6710 04:28:46,212 --> 04:28:48,948 THE WHOLE PROCESS. 6711 04:28:48,948 --> 04:28:50,449 THESE ARE SEVEN AREAS AND 6712 04:28:50,449 --> 04:28:51,617 CO-CHAIRS, FIRST BEING HEALTH 6713 04:28:51,617 --> 04:28:57,790 EQUITY AND PAIN ACROSS THE LIFE 6714 04:28:57,790 --> 04:28:59,258 COURSE, CHAIRED BY TAMARA BAKER, 6715 04:28:59,258 --> 04:29:08,201 A FOCUSED ON THE DEVELOPMENT OF 6716 04:29:08,201 --> 04:29:13,105 NON-ADDICTIVE THERAPEUTICS, JOHN 6717 04:29:13,105 --> 04:29:14,974 PRICE AND PAIN BIOMARKERS, 6718 04:29:14,974 --> 04:29:19,145 OPTIMIZATION OF INTERVENTION TO 6719 04:29:19,145 --> 04:29:24,050 IMPROVE PAIN, IMPLEMENTATION AND 6720 04:29:24,050 --> 04:29:27,153 HEALTH SERVICES HEADED BY LYNN 6721 04:29:27,153 --> 04:29:29,088 DEBAR WITH STEVE GEORGE. 6722 04:29:29,088 --> 04:29:35,528 INTERSECTION OF PAIN AND 6723 04:29:35,528 --> 04:29:39,799 SUBSTANCE USE DISORDER AND 6724 04:29:39,799 --> 04:29:42,602 FINALLY PAIN RESEARCH WORKFORCE 6725 04:29:42,602 --> 04:29:43,069 TRAINING. 6726 04:29:43,069 --> 04:29:45,805 NEXT SLIDE PLEASE. 6727 04:29:45,805 --> 04:29:48,774 THE PROCESS WAS AS FOLLOWS. 6728 04:29:48,774 --> 04:29:51,177 SUBCOMMITTEES MET, DELIBERATED, 6729 04:29:51,177 --> 04:29:53,546 INFORMED BY MEETINGS, WORKSHOPS, 6730 04:29:53,546 --> 04:29:53,713 RFI. 6731 04:29:53,713 --> 04:29:56,215 THE SUBCOMMITTEES DEVELOPED A 6732 04:29:56,215 --> 04:29:58,217 LIST OF RESEARCH PRIORITIES, 6733 04:29:58,217 --> 04:30:00,519 WITHIN THEIR GROUPS, KATHLEEN 6734 04:30:00,519 --> 04:30:02,855 AND I WITH JACKIE WORKED TO -- 6735 04:30:02,855 --> 04:30:05,391 THERE WAS A LOT OF OVERLAP AMONG 6736 04:30:05,391 --> 04:30:08,694 THE COMMITTEES SO WE WORKED TO 6737 04:30:08,694 --> 04:30:11,397 REFINE AND COMBINE SOME OF THOSE 6738 04:30:11,397 --> 04:30:16,102 TO GET DOWN TO A KIND OF MORE 6739 04:30:16,102 --> 04:30:21,774 SPECIFIC AND KIND OF HARMONIZED 6740 04:30:21,774 --> 04:30:23,709 ACROSS THE GROUPS SET OF 6741 04:30:23,709 --> 04:30:24,677 POTENTIAL PRIORITIES, SUBMITTED 6742 04:30:24,677 --> 04:30:26,245 THAT THROUGH THE FULL EXECUTIVE 6743 04:30:26,245 --> 04:30:28,948 COMMITTEE TO A MODIFIED DELPHI 6744 04:30:28,948 --> 04:30:31,450 PROCESS, PRIORITIZED ALL OF 6745 04:30:31,450 --> 04:30:33,219 THOSE ACROSS ALL THE 6746 04:30:33,219 --> 04:30:36,222 SUBCOMMITTEES, BASED ON THEIR 6747 04:30:36,222 --> 04:30:39,091 ABILITY TO ADVANCE THE HEAL-PAIN 6748 04:30:39,091 --> 04:30:41,294 MISSION, HERE ON THE SCREEN. 6749 04:30:41,294 --> 04:30:43,729 WE CAME UP WITH WHAT WE'RE GOING 6750 04:30:43,729 --> 04:30:45,765 TO PRESENT IN TERMS OF RESEARCH 6751 04:30:45,765 --> 04:30:46,565 PRIORITIES. 6752 04:30:46,565 --> 04:30:49,068 IN ADDITION THERE WERE A NUMBER 6753 04:30:49,068 --> 04:30:51,037 OF ITEMS THAT WERE REALLY 6754 04:30:51,037 --> 04:30:51,837 CONSISTENTLY COMING UP ACROSS 6755 04:30:51,837 --> 04:30:53,506 ALL OF THEM. 6756 04:30:53,506 --> 04:30:55,875 SO, IN ADDITION TO SPECIFIC 6757 04:30:55,875 --> 04:30:56,709 RESEARCH PRIORITIES, THE REPORT 6758 04:30:56,709 --> 04:31:00,880 HAS A SET OF CORE PRINCIPLES, 6759 04:31:00,880 --> 04:31:03,649 AND THEN TEN SPECIFIC RESEARCH 6760 04:31:03,649 --> 04:31:05,217 PRIORITIES FOR HEAL PAIN THAT 6761 04:31:05,217 --> 04:31:06,752 WE'RE PRESENTING HERE THAT CAN 6762 04:31:06,752 --> 04:31:10,323 BE USED TO INFORM A STRATEGIC 6763 04:31:10,323 --> 04:31:10,523 PLAN. 6764 04:31:10,523 --> 04:31:16,195 AND I'LL GO AHEAD AND MOVE 6765 04:31:16,195 --> 04:31:16,862 THROUGH THOSE. 6766 04:31:16,862 --> 04:31:17,563 NEXT SLIDE. 6767 04:31:17,563 --> 04:31:19,398 I'M GOING THROUGH THE CORE 6768 04:31:19,398 --> 04:31:20,800 PRINCIPLES AND THE RESEARCH 6769 04:31:20,800 --> 04:31:21,901 PRIORITIES BUT NOT PRESENTED IN 6770 04:31:21,901 --> 04:31:22,768 ANY SPECIFIC ORDER. 6771 04:31:22,768 --> 04:31:24,670 THIS IS NOT A RANK ORDERING OF 6772 04:31:24,670 --> 04:31:28,240 ONE TO TEN BECAUSE THEY ARE ALL 6773 04:31:28,240 --> 04:31:35,614 VERY CLOSELY ALIGNED IN TERMS OF 6774 04:31:35,614 --> 04:31:35,948 CORE. 6775 04:31:35,948 --> 04:31:39,852 THIS IS A GOOD PROCESS TO COME 6776 04:31:39,852 --> 04:31:41,287 TO CONSENSUS. 6777 04:31:41,287 --> 04:31:42,021 CORE PRINCIPLES SHOWN HERE 6778 04:31:42,021 --> 04:31:43,889 ACROSS THE BOARD INVOLVEMENT OF 6779 04:31:43,889 --> 04:31:48,194 PEOPLE WITH LIVED EXPERIENCE OF 6780 04:31:48,194 --> 04:31:50,863 PAIN IN THE HEAL, NIH HEAL 6781 04:31:50,863 --> 04:31:51,831 RESEARCH, INCLUDES TRAINING OF 6782 04:31:51,831 --> 04:31:54,934 INVESTIGATORS IN TERMS OF 6783 04:31:54,934 --> 04:31:55,601 WORKING WITH PEOPLE, INCLUSION 6784 04:31:55,601 --> 04:31:58,771 OF PEOPLE WITH LIVED EXPERIENCE, 6785 04:31:58,771 --> 04:32:03,876 BASIC AND CLINICAL RESEARCH, 6786 04:32:03,876 --> 04:32:06,245 INCLUSION THROUGH DESIGN AND 6787 04:32:06,245 --> 04:32:09,015 DATA ANALYSIS. 6788 04:32:09,015 --> 04:32:12,485 THERE'S A REAL STRONG CONSENSUS 6789 04:32:12,485 --> 04:32:15,554 OF NEED FOR EDUCATION, WE HEARD 6790 04:32:15,554 --> 04:32:18,724 ABOUT THAT MORE EARLIER IN THE 6791 04:32:18,724 --> 04:32:20,960 OPEN SESSION TODAY. 6792 04:32:20,960 --> 04:32:24,697 BUT NEEDING TO FIND WAYS TO 6793 04:32:24,697 --> 04:32:25,331 IMPROVE RESEARCH DISSEMINATION, 6794 04:32:25,331 --> 04:32:29,902 FINDINGS TO THE PUBLIC COMMUNITY 6795 04:32:29,902 --> 04:32:31,771 ENGAGEMENT FOR CLINICAL TRIALS 6796 04:32:31,771 --> 04:32:33,672 AND PUBLIC CAMPAIGN TO HIGHLIGHT 6797 04:32:33,672 --> 04:32:34,707 IMPORTANCE AND IMPACT OF 6798 04:32:34,707 --> 04:32:36,208 RESEARCH ON PAIN, SOME OF THAT 6799 04:32:36,208 --> 04:32:38,811 IS WITHIN THIS SCOPE OF WHAT THE 6800 04:32:38,811 --> 04:32:41,213 NIH CAN DO, SOME IS NOT BUT 6801 04:32:41,213 --> 04:32:49,321 THERE ARE WAYS TO DO THAT WORK. 6802 04:32:49,321 --> 04:32:50,356 THERE ARE METHODOLOGICAL 6803 04:32:50,356 --> 04:32:52,992 PRINCIPLES FOR RESEARCH, 6804 04:32:52,992 --> 04:32:56,195 REPORTING OF SEX, LOG ONE, USE 6805 04:32:56,195 --> 04:32:58,964 OF AGED ANIMALS TO CAPTURE PAIN 6806 04:32:58,964 --> 04:33:01,600 ACROSS THE LIFESPAN, STUDY OF 6807 04:33:01,600 --> 04:33:03,903 CO-OCCURRING CONDITIONS, 6808 04:33:03,903 --> 04:33:08,140 INFLUENCE OF SOCIAL FACTORS, AND 6809 04:33:08,140 --> 04:33:09,241 INTEGRATION OF IMPLEMENTATION 6810 04:33:09,241 --> 04:33:11,811 PRINCIPLES INTO ALL THE CLINICAL 6811 04:33:11,811 --> 04:33:14,980 RESEARCH STUDIES DONE. 6812 04:33:14,980 --> 04:33:15,881 THE USE OF INTERDISCIPLINARY 6813 04:33:15,881 --> 04:33:17,783 TEAMS SHOULD BE USED TO 6814 04:33:17,783 --> 04:33:20,219 CAPITALIZE ON SKILLS AND 6815 04:33:20,219 --> 04:33:21,887 METHODOLOGIES. 6816 04:33:21,887 --> 04:33:24,123 AND THEN A WAY TO ENABLE AND 6817 04:33:24,123 --> 04:33:27,059 PRIORITIZE SECONDARY ANALYSIS OF 6818 04:33:27,059 --> 04:33:28,227 EXISTING DATASETS AND BIOLOGICAL 6819 04:33:28,227 --> 04:33:29,695 SAMPLES, MANY OF THOSE WHICH ARE 6820 04:33:29,695 --> 04:33:33,032 ALREADY STORED IN THE HEAL DATA 6821 04:33:33,032 --> 04:33:34,500 ECOSYSTEM USED TO YIELD INSIGHTS 6822 04:33:34,500 --> 04:33:35,534 INTO THE GENESIS AND MAINTENANCE 6823 04:33:35,534 --> 04:33:36,902 OF CHRONIC PAIN. 6824 04:33:36,902 --> 04:33:38,671 THE CORE PRINCIPLES ARE THINGS 6825 04:33:38,671 --> 04:33:40,873 THAT SHOULD PERMEATE AND NOW 6826 04:33:40,873 --> 04:33:42,508 WE'LL TOUCH ON THE SPECIFIC 6827 04:33:42,508 --> 04:33:47,213 RESEARCH PRIORITIES WITH THE 6828 04:33:47,213 --> 04:33:49,548 NEXT SLIDE PLEASE. 6829 04:33:49,548 --> 04:33:53,486 THE FIRST OF THESE GOING TO THE 6830 04:33:53,486 --> 04:33:55,521 WORK FORCE AND TRAINING 6831 04:33:55,521 --> 04:34:05,898 COMMITTEE STRONG SUPPORT FOR 6832 04:34:05,898 --> 04:34:08,200 COMPREHENSIVE FELLOWSHIP, CAREER 6833 04:34:08,200 --> 04:34:08,801 DEVELOPMENT, RESEARCH SCHOLAR 6834 04:34:08,801 --> 04:34:19,345 AWARDS, NON-U.S. CITIZENS BEING 6835 04:34:20,212 --> 04:34:21,914 ELIGIBLE, FOSTER GROWTH, STRONG 6836 04:34:21,914 --> 04:34:23,215 POTENTIAL TO BRING THEM INTO THE 6837 04:34:23,215 --> 04:34:23,549 FOLD. 6838 04:34:23,549 --> 04:34:25,084 WE'VE SEEN IMPACT OF THAT, 6839 04:34:25,084 --> 04:34:27,686 PEOPLE COMING FROM OTHER FIELDS, 6840 04:34:27,686 --> 04:34:29,989 BRINGING NEW EXPERTISE TO THE 6841 04:34:29,989 --> 04:34:33,025 PAIN FIELD. 6842 04:34:33,025 --> 04:34:34,627 SO, STRONG SUPPORT FOR CAREER 6843 04:34:34,627 --> 04:34:35,828 DEVELOPMENT ACTIVITY. 6844 04:34:35,828 --> 04:34:40,766 THE SECOND ON THE NEXT SLIDE, 6845 04:34:40,766 --> 04:34:41,934 SUPPORT DEVELOPMENT OF 6846 04:34:41,934 --> 04:34:52,411 MECHANISTICALLY VARIED AND 6847 04:34:57,449 --> 04:34:59,585 HIGHLY EFFICACIOUS MODALITIES, 6848 04:34:59,585 --> 04:35:02,021 DEVELOPED IN THE FIRST 6849 04:35:02,021 --> 04:35:03,355 GENERATION FIELD, GOING FROM 6850 04:35:03,355 --> 04:35:07,092 SMALL MOLECULE DESIGN TO 6851 04:35:07,092 --> 04:35:09,195 CLINICAL TRIALS, AND INCLUDING 6852 04:35:09,195 --> 04:35:10,162 PRE-CLINICAL SCREENING PLATFORM 6853 04:35:10,162 --> 04:35:12,565 FOR PAIN THAT RIGOROUS ANIMAL 6854 04:35:12,565 --> 04:35:14,567 RESEARCH EVALUATION PROGRAM THAT 6855 04:35:14,567 --> 04:35:15,000 WAS DEVELOPED. 6856 04:35:15,000 --> 04:35:17,636 WE WANT TO CONTINUE SUPPORTING 6857 04:35:17,636 --> 04:35:19,271 THOSE EXISTING PROGRAMS ON SMALL 6858 04:35:19,271 --> 04:35:21,574 MOLECULES BUT ONE OF THE MAIN 6859 04:35:21,574 --> 04:35:22,641 THINGS WAS TO MAKE SURE THIS IS 6860 04:35:22,641 --> 04:35:27,913 OPENED UP TO NEW THERAPEUTIC 6861 04:35:27,913 --> 04:35:30,816 MODALITIES LIKE MONOCLONAL 6862 04:35:30,816 --> 04:35:34,153 ANTIBODIES, mRNA-BASED 6863 04:35:34,153 --> 04:35:36,789 THERAPIES, TARGET PROTEIN 6864 04:35:36,789 --> 04:35:38,591 DEGRADATION, DIFFERENT WAYS NOT 6865 04:35:38,591 --> 04:35:40,159 CURRENTLY SUPPORTED, STRONG 6866 04:35:40,159 --> 04:35:42,061 SUPPORT FOR ENABLING 6867 04:35:42,061 --> 04:35:43,596 INFRASTRUCTURE AROUND 6868 04:35:43,596 --> 04:35:49,335 THERAPEUTIC DEVELOPMENT. 6869 04:35:49,335 --> 04:35:52,238 THIS IS A GOAL TO INVEST IN 6870 04:35:52,238 --> 04:35:53,639 RESEARCH WITH FOCUS ON HUMAN 6871 04:35:53,639 --> 04:35:54,607 BIOLOGY, WHICH THERE'S SOME OF 6872 04:35:54,607 --> 04:35:57,576 THAT DONE NOW IN HEAL 1.0 BUT 6873 04:35:57,576 --> 04:35:59,245 THE GOAL TO SUPPORT DEVELOPMENT 6874 04:35:59,245 --> 04:36:01,247 OF NOVEL THERAPEUTICS IN A 6875 04:36:01,247 --> 04:36:02,047 COUPLE WAYS. 6876 04:36:02,047 --> 04:36:04,550 FIRST IS TO NOMINATE HIGH 6877 04:36:04,550 --> 04:36:06,685 QUALITY TARGETS FOR DEVELOPMENT 6878 04:36:06,685 --> 04:36:08,954 OF NEW PAIN THERAPEUTICS BASED 6879 04:36:08,954 --> 04:36:10,723 ON HUMAN BIOLOGY. 6880 04:36:10,723 --> 04:36:12,057 AND IMPORTANTLY ANOTHER THING 6881 04:36:12,057 --> 04:36:13,225 THAT WAS EMPHASIZED WAS USING 6882 04:36:13,225 --> 04:36:17,329 WHAT WE LEARNED FROM THAT HUMAN 6883 04:36:17,329 --> 04:36:18,731 BIOLOGY AND DISEASE SPECIFIC TO 6884 04:36:18,731 --> 04:36:23,669 SUPPORT A NEW GENERATION OF MORE 6885 04:36:23,669 --> 04:36:26,038 PREDICTIVE AND SPECIFIC MODELS 6886 04:36:26,038 --> 04:36:28,774 TO FACILITATE THERAPEUTIC 6887 04:36:28,774 --> 04:36:29,608 DEVELOPMENT IN THE LABORATORY. 6888 04:36:29,608 --> 04:36:32,144 SO I'M GOING TO HAND OFF TO MY 6889 04:36:32,144 --> 04:36:34,013 COLLEAGUE KATHLEEN TO PICK UP 6890 04:36:34,013 --> 04:36:41,587 THE REST OF THE RESEARCH 6891 04:36:41,587 --> 04:36:42,454 PRIORITIES. 6892 04:36:42,454 --> 04:36:44,189 >> NEXT SLIDE. 6893 04:36:44,189 --> 04:36:46,525 GREAT. 6894 04:36:46,525 --> 04:36:49,595 SO THE REST OF THESE PRIORITIES, 6895 04:36:49,595 --> 04:36:54,700 AND THERE WERE A LOT MORE BUT WE 6896 04:36:54,700 --> 04:37:00,205 TRIED TO COME UP WITH SOME THAT 6897 04:37:00,205 --> 04:37:03,642 WERE -- SOMEWHAT ENCOMPASSING 6898 04:37:03,642 --> 04:37:05,110 BUT GEARED TOWARDS MOVING 6899 04:37:05,110 --> 04:37:09,682 CURRENT TREATMENT AND DISCOVERY 6900 04:37:09,682 --> 04:37:11,317 OF POTENTIAL NEW TREATMENTS, 6901 04:37:11,317 --> 04:37:11,684 PRIMARILY -- 6902 04:37:11,684 --> 04:37:14,553 >> YOUR CALL MAY BE MONITORED 6903 04:37:14,553 --> 04:37:17,656 FOR QUALITY PURPOSES. 6904 04:37:17,656 --> 04:37:21,560 IF YOU'RE INTERESTED, PRESS ONE. 6905 04:37:21,560 --> 04:37:21,827 [LAUGHTER] 6906 04:37:21,827 --> 04:37:22,628 >> I'M GETTING SOMETHING. 6907 04:37:22,628 --> 04:37:25,798 ALL RIGHT. 6908 04:37:25,798 --> 04:37:27,199 WE'LL CONTINUE. 6909 04:37:27,199 --> 04:37:29,001 ANYWAYS, GEARED TOWARDS 6910 04:37:29,001 --> 04:37:30,703 IMPROVING THAT AND IDENTIFYING 6911 04:37:30,703 --> 04:37:32,905 MANY OF THESE IN HUMAN 6912 04:37:32,905 --> 04:37:36,975 POPULATIONS, AND THERE'S A FEW 6913 04:37:36,975 --> 04:37:40,479 INSTANCES WITH PRE-CLINICAL 6914 04:37:40,479 --> 04:37:41,380 STUDIES FACILITATING TRANSLATION 6915 04:37:41,380 --> 04:37:42,815 BOTH DIRECTIONS BETWEEN HUMANS 6916 04:37:42,815 --> 04:37:43,849 AND THE ANIMALS. 6917 04:37:43,849 --> 04:37:46,952 SO THE NEXT ONE THAT WE REALLY 6918 04:37:46,952 --> 04:37:51,557 ARE LOOKING AT IS TO DEVELOP 6919 04:37:51,557 --> 04:37:52,758 PAIN PREVENTION STRATEGIES THAT 6920 04:37:52,758 --> 04:37:56,161 PREVENT DEVELOPMENT OF CHRONIC 6921 04:37:56,161 --> 04:37:56,528 PAIN ALTOGETHER. 6922 04:37:56,528 --> 04:37:57,996 AND THE THOUGHT IS PEOPLE DON'T 6923 04:37:57,996 --> 04:37:59,298 WAKE UP ONE DAY WITH CHRONIC 6924 04:37:59,298 --> 04:38:02,301 PAIN SO IF WE CAN PREVENT IT 6925 04:38:02,301 --> 04:38:04,603 FROM TRANSITIONING TO CHRONIC 6926 04:38:04,603 --> 04:38:06,939 PAIN, WE WILL REDUCE THE BURDEN 6927 04:38:06,939 --> 04:38:08,273 OF CHRONIC PAIN ALTOGETHER. 6928 04:38:08,273 --> 04:38:11,543 AND SO IN ORDER TO DO THAT WE 6929 04:38:11,543 --> 04:38:14,213 HAVE TO DEVELOP AND TEST 6930 04:38:14,213 --> 04:38:16,682 SCREENING TOOLS AND BIOMARKERS 6931 04:38:16,682 --> 04:38:17,983 THAT CAN PREDICT THAT TRANSITION 6932 04:38:17,983 --> 04:38:21,053 TO CHRONIC PAIN BUT ALSO THAT 6933 04:38:21,053 --> 04:38:22,688 CAN PREDICT RESILIENCE AND 6934 04:38:22,688 --> 04:38:23,222 UNDERSTANDING THOSE COULD 6935 04:38:23,222 --> 04:38:28,026 POTENTIALLY GO BACK TO 6936 04:38:28,026 --> 04:38:31,263 THERAPEUTIC DEVELOPMENT BASED ON 6937 04:38:31,263 --> 04:38:32,865 THOSE BIOMARKERS. 6938 04:38:32,865 --> 04:38:34,733 THIS WOULD ENTAIL NOT ONLY 6939 04:38:34,733 --> 04:38:36,001 PREVENTING THE TRANSITION TO 6940 04:38:36,001 --> 04:38:39,037 CHRONIC PAIN AFTER ACUTE INJURY 6941 04:38:39,037 --> 04:38:44,676 BUT ALSO PREVENTING CHRONIC OR 6942 04:38:44,676 --> 04:38:48,180 ACUTE PAIN FROM OCCURRING FROM 6943 04:38:48,180 --> 04:38:49,515 WORKFORCE PROGRAMS, 6944 04:38:49,515 --> 04:38:52,017 DISEASE-MODIFYING TREATMENTS OR 6945 04:38:52,017 --> 04:38:53,152 LIFESTYLE MODIFICATIONS. 6946 04:38:53,152 --> 04:38:55,053 AND THEN LASTLY A LOT OF THESE, 6947 04:38:55,053 --> 04:38:56,922 THERE'S BEEN A NUMBER OF 6948 04:38:56,922 --> 04:38:58,724 PRE-CLINICAL STUDIES LOOKING AT 6949 04:38:58,724 --> 04:38:59,391 TRANSITION TO CHRONIC PAIN, SO A 6950 04:38:59,391 --> 04:39:01,326 LOT OF THIS COULD BE IF WE 6951 04:39:01,326 --> 04:39:02,661 IDENTIFY THESE MARKERS WE CAN 6952 04:39:02,661 --> 04:39:04,129 TAKE THEM TO ANIMALS AND SEE 6953 04:39:04,129 --> 04:39:06,632 WHAT THEIR ROLE IS OR IDENTIFY 6954 04:39:06,632 --> 04:39:07,933 MARKERS IN ANIMALS AND TAKE THEM 6955 04:39:07,933 --> 04:39:08,901 BACK TO HUMANS. 6956 04:39:08,901 --> 04:39:10,436 SO THIS ONE IS ABOUT PREVENTION 6957 04:39:10,436 --> 04:39:14,740 OF PAIN. 6958 04:39:14,740 --> 04:39:16,909 NEXT ONE. 6959 04:39:16,909 --> 04:39:17,810 RIGHT. 6960 04:39:17,810 --> 04:39:25,951 THE NEXT ONE IS REALLY TO 6961 04:39:25,951 --> 04:39:27,453 DEVELOP BIOMARKERS THAT PREDICT 6962 04:39:27,453 --> 04:39:27,886 TREATMENT RESPONSE. 6963 04:39:27,886 --> 04:39:29,755 SO WE ALL KNOW ONLY HALF OF 6964 04:39:29,755 --> 04:39:31,824 PEOPLE RESPOND TO ANY ONE GIVEN 6965 04:39:31,824 --> 04:39:36,762 TREATMENT, BUT WHAT ARE THE 6966 04:39:36,762 --> 04:39:37,896 FACTORS THAT IDENTIFY THOSE 6967 04:39:37,896 --> 04:39:38,764 PEOPLE AND RESPONDERS AND WHAT 6968 04:39:38,764 --> 04:39:40,332 ARE THE ONES THAT IDENTIFY THEY 6969 04:39:40,332 --> 04:39:41,200 ARE NOT RESPONDERS? 6970 04:39:41,200 --> 04:39:42,601 AND SO IN THE FIRST PLACE IN 6971 04:39:42,601 --> 04:39:46,939 ORDER TO DO THIS WE HAVE TO 6972 04:39:46,939 --> 04:39:48,073 IDENTIFY BIOMARKERS AND VARIOUS 6973 04:39:48,073 --> 04:39:49,708 RESPONSES THAT WILL PREDICT 6974 04:39:49,708 --> 04:39:50,909 THEIR TRANSITION. 6975 04:39:50,909 --> 04:39:52,010 PREDICT THEIR RESPONSE TO 6976 04:39:52,010 --> 04:39:54,613 TREATMENT, WITH THE HOPE THAT 6977 04:39:54,613 --> 04:39:56,548 EVENTUALLY WE CAN BETTER PICK 6978 04:39:56,548 --> 04:39:57,149 TREATMENTS. 6979 04:39:57,149 --> 04:39:58,150 RIGHT NOW MANY INDIVIDUALS WITH 6980 04:39:58,150 --> 04:39:59,751 CHRONIC PAIN, WE HEARD THIS FROM 6981 04:39:59,751 --> 04:40:02,187 OUR PEOPLE WITH LIVED 6982 04:40:02,187 --> 04:40:03,522 EXPERIENCE, WILL GO THROUGH 6983 04:40:03,522 --> 04:40:04,923 YEARS TRYING TO FIND OPTIMAL 6984 04:40:04,923 --> 04:40:06,225 TREATMENT AND WE'D LIKE TO CUT 6985 04:40:06,225 --> 04:40:08,560 THAT DOWN BY GETTING THEM TO THE 6986 04:40:08,560 --> 04:40:10,028 RIGHT TREATMENT SOONER. 6987 04:40:10,028 --> 04:40:12,364 IF WE CAN IDENTIFY THESE, THEY 6988 04:40:12,364 --> 04:40:14,800 COULD SERVE AS SURROGATE 6989 04:40:14,800 --> 04:40:17,469 ENDPOINTS IN CLINICAL TRIALS, 6990 04:40:17,469 --> 04:40:20,205 INCORPORATED, WILL REQUIRE 6991 04:40:20,205 --> 04:40:21,740 RIGOROUS VALIDATION AND WE CAN 6992 04:40:21,740 --> 04:40:24,510 BEGIN TO LOOK AT A NUMBER OF 6993 04:40:24,510 --> 04:40:28,747 PREDICTIVE AND PROGNOSTIC AS 6994 04:40:28,747 --> 04:40:31,583 WELL AS PHARMACODYNAMIC 6995 04:40:31,583 --> 04:40:32,718 BIOMARKERS FOR IMPROVING 6996 04:40:32,718 --> 04:40:37,289 TREATMENT RESPONSE. 6997 04:40:37,289 --> 04:40:37,823 OKAY. 6998 04:40:37,823 --> 04:40:38,490 NEXT. 6999 04:40:38,490 --> 04:40:39,858 THE OTHER THING WE INHERENTLY 7000 04:40:39,858 --> 04:40:41,994 KNOW IS THAT IF WE UNDERSTAND 7001 04:40:41,994 --> 04:40:45,330 THE MECHANISMS AND WE TREAT 7002 04:40:45,330 --> 04:40:46,632 WHAT'S GOING ON, THE UNDERLYING 7003 04:40:46,632 --> 04:40:50,602 CHANGES IN THE NERVOUS SYSTEM OR 7004 04:40:50,602 --> 04:40:53,272 THE BODY, THEN PERHAPS WE CAN 7005 04:40:53,272 --> 04:40:54,640 GET BETTER TREATMENT OUTCOME. 7006 04:40:54,640 --> 04:40:56,241 AND THAT'S, YOU KNOW, THAT'S HOW 7007 04:40:56,241 --> 04:40:58,944 WE DEVELOP OUR NEW THERAPEUTICS, 7008 04:40:58,944 --> 04:41:00,212 WE IDENTIFY MECHANISMS, DEVELOP 7009 04:41:00,212 --> 04:41:02,447 A DRUG FOR IT, AND WE TREAT 7010 04:41:02,447 --> 04:41:03,048 THAT. 7011 04:41:03,048 --> 04:41:06,018 AND SO WE'RE LOOKING TO SEE IN 7012 04:41:06,018 --> 04:41:10,722 THIS ONE IF WE CAN DEVELOP 7013 04:41:10,722 --> 04:41:11,390 INDIVIDUALIZED TAILORED 7014 04:41:11,390 --> 04:41:11,990 MECHANISM-BASED APPROACHES TO 7015 04:41:11,990 --> 04:41:13,125 THE TREATMENT OF CHRONIC PAIN. 7016 04:41:13,125 --> 04:41:15,394 THIS IS REALLY GETTING TOWARDS 7017 04:41:15,394 --> 04:41:17,229 PERSONALIZED MEDICINE WHERE WE 7018 04:41:17,229 --> 04:41:20,265 ULTIMATELY WOULD LIKE TO BE. 7019 04:41:20,265 --> 04:41:23,635 IN ORDER TO DO THAT WE HAVE TO 7020 04:41:23,635 --> 04:41:25,604 DEVELOP PAIN BIOSIGNATURES OR 7021 04:41:25,604 --> 04:41:28,006 COMPOSITE PAIN SIGNATURES THAT 7022 04:41:28,006 --> 04:41:30,075 NOT ONLY INCLUDES BIOLOGICAL 7023 04:41:30,075 --> 04:41:35,314 MARKERS BUT PATIENT-RECORDED 7024 04:41:35,314 --> 04:41:38,684 OUTCOMES TO CAPTURE COMPLEXITY 7025 04:41:38,684 --> 04:41:40,652 AND NATURE OF PAIN, PSYCHOSOCIAL 7026 04:41:40,652 --> 04:41:44,323 PROCESSES AS WELL AS BIOLOGICAL 7027 04:41:44,323 --> 04:41:44,823 PROCESS. 7028 04:41:44,823 --> 04:41:51,163 IN ORDER TO ALSO DO THIS, 7029 04:41:51,163 --> 04:41:52,097 NON-PHARMACOLOGIC OR NON-DRUG 7030 04:41:52,097 --> 04:41:53,165 TREATMENT ALSO ARE KEY 7031 04:41:53,165 --> 04:41:55,601 TREATMENTS IN CHRONIC PAIN AND 7032 04:41:55,601 --> 04:41:56,668 PROVIDE ADDITIONAL HELP AND 7033 04:41:56,668 --> 04:41:59,738 RELIEF FOR PEOPLE WITH CHRONIC 7034 04:41:59,738 --> 04:42:04,109 PAIN, LIKE EXERCISE AND 7035 04:42:04,109 --> 04:42:06,111 ACUPUNCTURE OR OTHER COGNITIVE 7036 04:42:06,111 --> 04:42:07,646 BEHAVIORAL THERAPY BUT WE DON'T 7037 04:42:07,646 --> 04:42:08,714 KNOW MECHANISMS OF A LOT OF 7038 04:42:08,714 --> 04:42:08,981 THESE. 7039 04:42:08,981 --> 04:42:10,882 WE'RE BEGINNING TO GET SOME BUT 7040 04:42:10,882 --> 04:42:12,184 NEED TO UNDERSTAND THOSE THAT 7041 04:42:12,184 --> 04:42:14,386 ARE SO WE CAN BETTER USE THEM 7042 04:42:14,386 --> 04:42:15,921 AND WE NEED TO ACTUALLY TEST 7043 04:42:15,921 --> 04:42:21,226 WHETHER OR NOT USING THE 7044 04:42:21,226 --> 04:42:21,960 PERSONALIZED APPROACH WORKS 7045 04:42:21,960 --> 04:42:23,528 BETTER THAN STANDARD OF CARE WE 7046 04:42:23,528 --> 04:42:24,162 TYPICALLY GIVE A PERSON. 7047 04:42:24,162 --> 04:42:26,632 WE THINK THIS IS THE BEST 7048 04:42:26,632 --> 04:42:29,768 APPROACH, YET THERE ISN'T ANY 7049 04:42:29,768 --> 04:42:35,073 DATA TO SUGGEST THAT. 7050 04:42:35,073 --> 04:42:38,877 THE NEXT AIM, SO THE NEXT 7051 04:42:38,877 --> 04:42:42,848 PRIORITY WE CAME UP WITH WAS TO 7052 04:42:42,848 --> 04:42:46,084 LOOK AT DEVELOPING AND TESTING 7053 04:42:46,084 --> 04:42:50,689 KIND OF AN EVIDENCE-BASED 7054 04:42:50,689 --> 04:42:52,090 GUIDANCE FOR CLINICIANS APPROACH 7055 04:42:52,090 --> 04:42:55,560 TO CHRONIC PAIN WHERE WE 7056 04:42:55,560 --> 04:42:57,362 DETERMINE THE ORDER, THE TIMING, 7057 04:42:57,362 --> 04:42:59,798 WHAT SHOULD INITIAL THERAPY BE, 7058 04:42:59,798 --> 04:43:01,233 WHAT APPROACHES SHOULD BE 7059 04:43:01,233 --> 04:43:03,068 COMBINED, WHAT IS THE SEQUENCE 7060 04:43:03,068 --> 04:43:04,369 OF THOSE APPROACHES, DO THEY ALL 7061 04:43:04,369 --> 04:43:07,706 GO AT THE SAME TIME? 7062 04:43:07,706 --> 04:43:09,741 AND WHAT ARE NON-SPECIFIC 7063 04:43:09,741 --> 04:43:11,710 EFFECTS OF THOSE AND HOW DO WE 7064 04:43:11,710 --> 04:43:13,111 PUT THOSE ALL TOGETHER? 7065 04:43:13,111 --> 04:43:16,014 AND, AGAIN, IN ORDER TO DO THIS 7066 04:43:16,014 --> 04:43:18,583 YOU'LL SEE OFTENTIMES WHILE WE 7067 04:43:18,583 --> 04:43:19,651 HAVE SEPARATE ONES ON BIOMARKERS 7068 04:43:19,651 --> 04:43:21,887 YOU'LL SEE THEM COME UP AGAIN 7069 04:43:21,887 --> 04:43:23,655 AND AGAIN, WE HAVE TO IDENTIFY 7070 04:43:23,655 --> 04:43:25,624 THE PREDICTORS OF THE TREATMENT 7071 04:43:25,624 --> 04:43:27,392 RESPONSE IN ORDER TO HELP DOING 7072 04:43:27,392 --> 04:43:27,893 THIS. 7073 04:43:27,893 --> 04:43:30,729 WE NEED TO EVALUATE COMBINATIONS 7074 04:43:30,729 --> 04:43:31,263 OF THERAPIES. 7075 04:43:31,263 --> 04:43:33,165 NOT SINGLE THERAPIES ALL ON 7076 04:43:33,165 --> 04:43:34,332 THEIR OWN ANYMORE. 7077 04:43:34,332 --> 04:43:38,203 AND THEN THE TIMING OF WHEN TO 7078 04:43:38,203 --> 04:43:39,604 APPLY THESE APPROACHES, THERE'S 7079 04:43:39,604 --> 04:43:41,406 A BEST TIME TO APPLY EXERCISE, 7080 04:43:41,406 --> 04:43:43,475 RIGHT AWAY, OR SHOULD THAT BE 7081 04:43:43,475 --> 04:43:46,011 WAITING SIX TO EIGHT WEEKS LIKE 7082 04:43:46,011 --> 04:43:49,681 OFTENTIMES IT IS NOW? 7083 04:43:49,681 --> 04:43:52,217 WE NEED EVALUATE NOT ONLY 7084 04:43:52,217 --> 04:43:54,853 PHARMACOLOGICAL THERAPIES BUT WE 7085 04:43:54,853 --> 04:43:57,255 NEED TO EVALUATE THOSE IN 7086 04:43:57,255 --> 04:43:58,957 ADDITION AND COMBINED WITH 7087 04:43:58,957 --> 04:44:00,659 NON-DRUG APPROACHES AND 7088 04:44:00,659 --> 04:44:01,960 UNDERSTAND THE NON-SPECIFIC 7089 04:44:01,960 --> 04:44:03,261 EFFECTS OF THEIR INFLUENCE ON 7090 04:44:03,261 --> 04:44:03,562 PAIN. 7091 04:44:03,562 --> 04:44:09,134 AND MAYBE HOW TO MAXIMIZE THOSE 7092 04:44:09,134 --> 04:44:17,175 NON-SPECIFIC EFFECTS ON PAIN. 7093 04:44:17,175 --> 04:44:17,509 NEXT PRIORITY. 7094 04:44:17,509 --> 04:44:19,010 THIS PRIORITY IS ABOUT ONCE 7095 04:44:19,010 --> 04:44:21,079 WE'VE IDENTIFIED ALL THESE 7096 04:44:21,079 --> 04:44:22,514 REALLY GREAT STRATEGIES WE'VE 7097 04:44:22,514 --> 04:44:23,782 DEVELOPED SOME, WE NEED TO 7098 04:44:23,782 --> 04:44:25,183 FIGURE OUT TO YOU TO GET FROM 7099 04:44:25,183 --> 04:44:27,185 THE CLINIC, IF THEY WORK IN A 7100 04:44:27,185 --> 04:44:28,987 REAL WORLD SETTING. 7101 04:44:28,987 --> 04:44:33,859 THIS IS ABOUT IMPLEMENTATION. 7102 04:44:33,859 --> 04:44:37,729 AND LOOKING AT REALLY 7103 04:44:37,729 --> 04:44:39,798 PRIORITIZING CLINICAL TRIALS AND 7104 04:44:39,798 --> 04:44:41,333 COMMUNITY-BASED RESEARCH, AND WE 7105 04:44:41,333 --> 04:44:42,968 RECOGNIZE THAT THIS HAS BEEN A 7106 04:44:42,968 --> 04:44:44,269 BIG PART OF THE LAST HEAL 7107 04:44:44,269 --> 04:44:45,837 INITIATIVE, A NUMBER OF 7108 04:44:45,837 --> 04:44:51,610 PRAGMATIC CLINICAL TRIALS, 7109 04:44:51,610 --> 04:44:53,779 CLINICAL EFFECTIVENESS THAT 7110 04:44:53,779 --> 04:44:55,180 WORKS, THE PRISM NETWORK LOOKING 7111 04:44:55,180 --> 04:44:57,883 AT NON-DRUG THERAPIES IN THE 7112 04:44:57,883 --> 04:45:01,052 REAL WORLD, LIKELY USEFUL TO 7113 04:45:01,052 --> 04:45:02,687 CONTINUE BECAUSE THEY ARE NOW -- 7114 04:45:02,687 --> 04:45:04,990 THESE ARE SOME BIG TRIALS NOW 7115 04:45:04,990 --> 04:45:08,794 COMING UP STARTING TO GET 7116 04:45:08,794 --> 04:45:11,797 RESEARCH DATA OUT FROM THE FIRST 7117 04:45:11,797 --> 04:45:12,864 SETS OF TRIALS. 7118 04:45:12,864 --> 04:45:14,833 BUT WE NEED TO ACTUALLY LOOK AT 7119 04:45:14,833 --> 04:45:18,770 THESE IN THE REAL WORLD. 7120 04:45:18,770 --> 04:45:20,705 WE NEED TO ALIGN THESE, WHAT CAN 7121 04:45:20,705 --> 04:45:23,108 BE DONE IN A REAL CLINICAL 7122 04:45:23,108 --> 04:45:24,843 SETTING, WHAT IS MEANINGFUL TO 7123 04:45:24,843 --> 04:45:26,778 THE STAKEHOLDERS, EITHER THE 7124 04:45:26,778 --> 04:45:29,748 HEALTHCARE SYSTEM PART OR THE 7125 04:45:29,748 --> 04:45:30,782 PAYERS, IN THIS CASE. 7126 04:45:30,782 --> 04:45:38,857 OR IF THE PEOPLE WITH LIVED 7127 04:45:38,857 --> 04:45:39,391 EXPERIENCE, WHETHER OR NOT 7128 04:45:39,391 --> 04:45:40,926 SHARED DECISION MAKING TOOLS ARE 7129 04:45:40,926 --> 04:45:42,894 HELPFUL AND SEE ABOUT 7130 04:45:42,894 --> 04:45:45,430 INTEGRATING THEM INTO THESE 7131 04:45:45,430 --> 04:45:45,730 TRIALS. 7132 04:45:45,730 --> 04:45:47,599 WE NEED TO THINK ABOUT 7133 04:45:47,599 --> 04:45:49,668 INTEGRATED CARE MODELS IN THE 7134 04:45:49,668 --> 04:45:52,270 HEALTH CARE SETTING. 7135 04:45:52,270 --> 04:45:53,338 AND VARIOUS COMMUNITY SETTINGS, 7136 04:45:53,338 --> 04:45:55,040 NOT JUST HEALTH CARE BUT ALSO 7137 04:45:55,040 --> 04:45:56,474 COMMUNITY SETTINGS PARTICULARLY 7138 04:45:56,474 --> 04:45:59,711 IN CERTAIN ENVIRONMENTS THAT MAY 7139 04:45:59,711 --> 04:46:04,115 HAVE LESS ACCESS TO A VARIETY OF 7140 04:46:04,115 --> 04:46:04,549 HEALTHCARE SYSTEMS. 7141 04:46:04,549 --> 04:46:05,984 THEN ONE OF THE OTHER KEY 7142 04:46:05,984 --> 04:46:08,486 FACTORS I THINK CAME OUT WAS 7143 04:46:08,486 --> 04:46:10,956 THAT IN ADDITION TO IMPLEMENTING 7144 04:46:10,956 --> 04:46:13,191 WHAT WE THINK ARE HIGH VALUE OR 7145 04:46:13,191 --> 04:46:15,393 QUITE EFFECTIVE AND EASY TO 7146 04:46:15,393 --> 04:46:16,661 IMPLEMENT INTERVENTIONS, THESE 7147 04:46:16,661 --> 04:46:19,231 NEED TO BE COMBINED WITH 7148 04:46:19,231 --> 04:46:20,699 DEIMPLEMENTING LOW VALUE MAYBE 7149 04:46:20,699 --> 04:46:22,868 HIGH RISK OR HIGH EXPENSE 7150 04:46:22,868 --> 04:46:24,069 INTERVENTIONS THAT ARE STILL 7151 04:46:24,069 --> 04:46:27,672 GOING ON ON A REGULAR BASIS IN 7152 04:46:27,672 --> 04:46:29,241 INDIVIDUALS WITH CHRONIC PAIN. 7153 04:46:29,241 --> 04:46:34,145 AND SO THIS IS REALLY WHERE THE 7154 04:46:34,145 --> 04:46:36,948 NEXT STAGE IS REALLY GETTING 7155 04:46:36,948 --> 04:46:38,483 THEM TO IMPLEMENTATION AND 7156 04:46:38,483 --> 04:46:46,391 EFFECTIVENESS IN THE REAL WORLD 7157 04:46:46,391 --> 04:46:48,226 SO THE NEXT PRIORITY, WE KNOW A 7158 04:46:48,226 --> 04:46:53,198 LOT OF PEOPLE GO ON TO CHRONIC 7159 04:46:53,198 --> 04:46:59,738 PAIN OR HAVE CHRONIC PAIN USE A 7160 04:46:59,738 --> 04:47:01,039 NUMBER OF SUBSTANCES, AND 7161 04:47:01,039 --> 04:47:03,108 SOMETIMES MISUSE SOME OF THOSE 7162 04:47:03,108 --> 04:47:05,110 SUBSTANCES, AND SO THIS PRIORITY 7163 04:47:05,110 --> 04:47:07,045 IS AROUND THE COMBINATION OF 7164 04:47:07,045 --> 04:47:11,049 SUBSTANCE USE AND PAIN TOGETHER, 7165 04:47:11,049 --> 04:47:15,253 AND IT IS TO IDENTIFY WHO -- 7166 04:47:15,253 --> 04:47:16,588 WHICH POPULATIONS THAT ARE 7167 04:47:16,588 --> 04:47:17,589 DISPROPORTIONATELY AND HIGHLY 7168 04:47:17,589 --> 04:47:20,058 IMPACTED BY BOTH OF THESE, BOTH 7169 04:47:20,058 --> 04:47:24,763 PAIN AND SUBSTANCE USE, AND 7170 04:47:24,763 --> 04:47:28,066 UNDERSTAND THE MECHANISMS THAT 7171 04:47:28,066 --> 04:47:30,068 IMPACT THESE POPULATIONS. 7172 04:47:30,068 --> 04:47:35,240 AND TO DEVELOP AND TEST 7173 04:47:35,240 --> 04:47:36,975 INTERVENTIONS TO ADDRESS IMPACT. 7174 04:47:36,975 --> 04:47:39,010 NOT EVERYBODY WHO IS GIVEN AN 7175 04:47:39,010 --> 04:47:40,745 OPIOID FOR INSTANCE WILL DEVELOP 7176 04:47:40,745 --> 04:47:42,881 SUBSTANCE USE DISORDER. 7177 04:47:42,881 --> 04:47:44,082 OBVIOUSLY PROPORTION DO SO 7178 04:47:44,082 --> 04:47:46,217 TRYING TO FIGURE OUT WHICH ONES 7179 04:47:46,217 --> 04:47:54,326 ARE AND WHAT THOSE ARE, 7180 04:47:54,326 --> 04:47:55,727 PARTICULARLY THOSE WITH PAIN. 7181 04:47:55,727 --> 04:47:58,129 THERE'S A NUMBER OF THINGS DOWN 7182 04:47:58,129 --> 04:48:00,198 UNDERNEATH HERE ABOUT WHAT THOSE 7183 04:48:00,198 --> 04:48:01,766 INTERVENTIONS COULD BE, OR 7184 04:48:01,766 --> 04:48:04,202 SHOULD BE, REALLY TESTING 7185 04:48:04,202 --> 04:48:07,772 INTERVENTIONS WITH HIGH 7186 04:48:07,772 --> 04:48:10,842 POTENTIAL FOR IMPACT, LOOKING AT 7187 04:48:10,842 --> 04:48:13,311 UNDERLYING MECHANISMS AND THEIR 7188 04:48:13,311 --> 04:48:15,447 RELATIONSHIP, AND EVEN TAKING 7189 04:48:15,447 --> 04:48:19,918 THESE BACK TO AN IMPLEMENTATION 7190 04:48:19,918 --> 04:48:21,720 AND EVIDENCE-BASED APPROACHES 7191 04:48:21,720 --> 04:48:26,057 THAT ADDRESS THIS COMPLEXITY. 7192 04:48:26,057 --> 04:48:27,959 OKAY. 7193 04:48:27,959 --> 04:48:29,027 SO THE NEXT ONE. 7194 04:48:29,027 --> 04:48:31,997 AND THIS ONE WAS CALLED OUT AS A 7195 04:48:31,997 --> 04:48:32,964 SEPARATE ONE. 7196 04:48:32,964 --> 04:48:35,433 IT DIDN'T ACTUALLY START THERE 7197 04:48:35,433 --> 04:48:38,470 BUT THERE WAS A LOT OF THOUGHTS 7198 04:48:38,470 --> 04:48:44,943 AROUND THE USE OF NON-DRUG OR 7199 04:48:44,943 --> 04:48:45,610 NON-PHARMACOLOGICAL TREATMENTS, 7200 04:48:45,610 --> 04:48:49,647 YET HASN'T BEEN CALLED OUT IN 7201 04:48:49,647 --> 04:48:51,116 SEPARATE CALLS BEFORE, SEPARATE 7202 04:48:51,116 --> 04:48:54,619 RESEARCH, AND IT'S BEEN EMBEDDED 7203 04:48:54,619 --> 04:48:55,286 ALONG WITH PHARMACEUTICAL 7204 04:48:55,286 --> 04:48:56,454 RESEARCH YET THERE'S A LOT WE 7205 04:48:56,454 --> 04:48:58,723 DON'T KNOW ABOUT THESE NON-DRUG 7206 04:48:58,723 --> 04:48:59,758 APPROACHES FOR TREATMENT OF 7207 04:48:59,758 --> 04:49:00,191 PAIN. 7208 04:49:00,191 --> 04:49:02,994 AND SO THIS IS A SEPARATE ENTITY 7209 04:49:02,994 --> 04:49:05,230 TO HIGHLIGHT THE IMPORTANCE OF 7210 04:49:05,230 --> 04:49:07,332 FOCUSING ON NON-DRUG APPROACHES. 7211 04:49:07,332 --> 04:49:08,900 WE KNOW THESE ARE OFTEN FIRST 7212 04:49:08,900 --> 04:49:12,237 LINE TREATMENTS FOR PEOPLE WITH 7213 04:49:12,237 --> 04:49:18,843 CHRONIC PAIN, PHYSICAL THERAPY 7214 04:49:18,843 --> 04:49:19,377 APPROACHES, EXERCISE, 7215 04:49:19,377 --> 04:49:23,348 ACUPUNCTURE OFTEN USED RIGHT 7216 04:49:23,348 --> 04:49:25,150 AWAY IN THE BEGINNING OR SHOULD 7217 04:49:25,150 --> 04:49:30,221 BE USED MORE FREQUENTLY SO THIS 7218 04:49:30,221 --> 04:49:32,857 SUGGESTS WE NEED TO IDENTIFY 7219 04:49:32,857 --> 04:49:33,792 THESE EVIDENCE-BASED APPROACHES 7220 04:49:33,792 --> 04:49:40,365 NOT ONLY FOR PAIN BUT ALSO FOR 7221 04:49:40,365 --> 04:49:40,732 ADDICTION. 7222 04:49:40,732 --> 04:49:42,667 PEOPLE WITH THE PAIN AND 7223 04:49:42,667 --> 04:49:48,173 SUBSTANCE USE, AND TAILOR THESE 7224 04:49:48,173 --> 04:49:50,108 ARE VERY USING HYBRID 7225 04:49:50,108 --> 04:49:51,443 IMPLEMENTATION TRIALS. 7226 04:49:51,443 --> 04:49:59,084 AND THEN, AGAIN, FOCUS ON 7227 04:49:59,084 --> 04:50:00,418 UNDERLYING GETTING MECHANISMS, 7228 04:50:00,418 --> 04:50:01,386 LOOKING FOR RESPONDER ANALYSIS 7229 04:50:01,386 --> 04:50:05,757 WHICH ARE OFTEN NOT DONE IN 7230 04:50:05,757 --> 04:50:07,192 THESE TRIALS, BUT WE NEED TO 7231 04:50:07,192 --> 04:50:08,960 BEGIN TO FIGURE OUT WHAT THE 7232 04:50:08,960 --> 04:50:10,495 PREDICTORS ARE AND BIOMARKERS 7233 04:50:10,495 --> 04:50:12,730 ARE FOR THE RESPONDERS IN THESE 7234 04:50:12,730 --> 04:50:16,034 AS WELL. 7235 04:50:16,034 --> 04:50:18,203 AND THEN OPTIMAL TIMING OF THE 7236 04:50:18,203 --> 04:50:18,536 INTERVENTION. 7237 04:50:18,536 --> 04:50:21,606 AGAIN, SOME OVERLAP WITH SOME 7238 04:50:21,606 --> 04:50:24,175 OTHER PRIORITIES BY CALLING THIS 7239 04:50:24,175 --> 04:50:33,151 OUT AS A SEPARATE ENTITY. 7240 04:50:33,151 --> 04:50:34,419 AND I BELIEVE THAT MIGHT BE OUR 7241 04:50:34,419 --> 04:50:35,186 LAST PRIORITY. 7242 04:50:35,186 --> 04:50:35,954 NEXT SLIDE. 7243 04:50:35,954 --> 04:50:36,187 YES. 7244 04:50:36,187 --> 04:50:39,224 THIS IS A SUMMARY OF THEM IN ONE 7245 04:50:39,224 --> 04:50:41,126 SLIDE, IF YOU WANT, BUT YOU CAN 7246 04:50:41,126 --> 04:50:47,365 SEE THEY ARE WRAPPED AROUND 7247 04:50:47,365 --> 04:50:50,335 TRAINING, DRUG DEVELOPMENT, 7248 04:50:50,335 --> 04:50:52,237 BIOMARKERS, CLINICAL -- 7249 04:50:52,237 --> 04:50:53,538 IMPROVING CLINICAL TREATMENT 7250 04:50:53,538 --> 04:50:54,272 ULTIMATELY IMPROVING CLINICAL 7251 04:50:54,272 --> 04:50:58,276 TREATMENT THROUGH CLINICAL 7252 04:50:58,276 --> 04:51:00,145 TRIALS AND IMPLEMENTATION 7253 04:51:00,145 --> 04:51:00,378 STUDIES. 7254 04:51:00,378 --> 04:51:07,619 NEXT SLIDE. 7255 04:51:07,619 --> 04:51:14,259 THIS WAS A MULTI-TEAM APPROACH, 7256 04:51:14,259 --> 04:51:17,362 FANTASTIC, ALL THESE MEMBERS WHO 7257 04:51:17,362 --> 04:51:20,298 SERVED ACROSS THE SEVEN 7258 04:51:20,298 --> 04:51:22,333 SUBGROUPS WERE VERY ENGAGED, AND 7259 04:51:22,333 --> 04:51:24,135 THIS WOULDN'T HAVE BEEN DONE 7260 04:51:24,135 --> 04:51:24,536 WITHOUT THEM. 7261 04:51:24,536 --> 04:51:27,906 THIS IS JUST A LIST OF EVERYBODY 7262 04:51:27,906 --> 04:51:31,009 WHO PARTICIPATED, SO AS WELL AS 7263 04:51:31,009 --> 04:51:33,545 THAT VERY LONG LIST OF NIH STAFF 7264 04:51:33,545 --> 04:51:37,916 WHO HELPED US ALONG THIS JOURNEY 7265 04:51:37,916 --> 04:51:39,417 AS WE PUT THIS TOGETHER. 7266 04:51:39,417 --> 04:51:42,520 IT WAS A RATHER RAPID TIME 7267 04:51:42,520 --> 04:51:44,322 FRAME, SO AGAIN IT WOULDN'T HAVE 7268 04:51:44,322 --> 04:51:45,890 BEEN DONE WITHOUT A LOT OF 7269 04:51:45,890 --> 04:51:49,594 PEOPLE WORKING TOGETHER IN A 7270 04:51:49,594 --> 04:51:51,396 REALLY THOUGHTFUL MANNER. 7271 04:51:51,396 --> 04:51:57,135 WITH THAT, I THINK THERE ARE NO 7272 04:51:57,135 --> 04:51:57,435 MORE SLIDES. 7273 04:51:57,435 --> 04:51:59,170 YEP, WE'LL JUST THANK YOU. 7274 04:51:59,170 --> 04:52:02,640 THIS WAS OUR WORKING GROUP AT 7275 04:52:02,640 --> 04:52:05,143 WashU AT ROB'S PLACE, THIS IS 7276 04:52:05,143 --> 04:52:06,144 THE EXECUTIVE COMMITTEE. 7277 04:52:06,144 --> 04:52:11,849 THIS WAS AFTER WE HAD FINALIZED 7278 04:52:11,849 --> 04:52:12,750 OUR PRIORITIES. 7279 04:52:12,750 --> 04:52:16,020 WITH THAT WE'RE VERY HAPPY TO 7280 04:52:16,020 --> 04:52:17,455 ANSWER ANY QUESTIONS YOU MIGHT 7281 04:52:17,455 --> 04:52:22,360 HAVE OR TAKE ANY COMMENTS. 7282 04:52:22,360 --> 04:52:26,064 >> THANKS. 7283 04:52:26,064 --> 04:52:34,505 KATE HAS A QUESTION. 7284 04:52:34,505 --> 04:52:36,174 >> CAN YOU HEAR ME NOW? 7285 04:52:36,174 --> 04:52:37,242 >> GOT YOU KNOW. 7286 04:52:37,242 --> 04:52:38,710 >> THERE WAS BACKGROUND NOISE. 7287 04:52:38,710 --> 04:52:42,213 SO FIRST I WANT TO APOLOGIZE, 7288 04:52:42,213 --> 04:52:46,117 THERE WAS AN ISSUE WITH MY LINK, 7289 04:52:46,117 --> 04:52:48,052 THANK YOU FOR PERSISTING. 7290 04:52:48,052 --> 04:52:51,489 I WANTED TO THANK BOTH OF YOU, 7291 04:52:51,489 --> 04:52:52,890 SOMEONE WHO IS TANGENTIALLY 7292 04:52:52,890 --> 04:52:54,892 INVOLVED, I KNOW HOW MUCH WORK 7293 04:52:54,892 --> 04:52:57,762 THIS ENTAILED AND I THINK THE 7294 04:52:57,762 --> 04:53:01,032 PRIORITIES ARE EXCELLENT AND 7295 04:53:01,032 --> 04:53:02,834 REALLY REFLECTIVE OF VERY 7296 04:53:02,834 --> 04:53:03,268 THOUGHTFUL PROCESS. 7297 04:53:03,268 --> 04:53:05,270 MY QUESTION GIVEN THE ENORMOUS 7298 04:53:05,270 --> 04:53:08,206 IMPORTANCE OF "HEAL" AND THE 7299 04:53:08,206 --> 04:53:09,907 PAIN ASPECT OF "HEAL" IS GIVEN 7300 04:53:09,907 --> 04:53:11,909 THIS IS AN INTACT REPORT AND WE 7301 04:53:11,909 --> 04:53:14,312 HAVE A NEW ADMINISTRATION WITH 7302 04:53:14,312 --> 04:53:17,448 NEW PRIORITIES AND SOME 7303 04:53:17,448 --> 04:53:20,285 DISCUSSION THAT WE HAD WITH DR. 7304 04:53:20,285 --> 04:53:21,185 BHATTACHARYA EARLIER, WHETHER 7305 04:53:21,185 --> 04:53:24,188 THERE WILL BE ANY THOUGHT TO HOW 7306 04:53:24,188 --> 04:53:26,257 TO COMMUNICATE SOME ASPECTS OF 7307 04:53:26,257 --> 04:53:26,991 THIS. 7308 04:53:26,991 --> 04:53:28,626 I FEEL LIKE SEVERAL THINGS ALIGN 7309 04:53:28,626 --> 04:53:33,464 WITH SOME PRIORITIES THAT HAVE 7310 04:53:33,464 --> 04:53:39,537 BEEN DISCUSSED TODAY, HUGE 7311 04:53:39,537 --> 04:53:40,305 BIOLOGY, TRANSLATION, 7312 04:53:40,305 --> 04:53:41,439 PREVENTION, THE ELEPHANT IN THE 7313 04:53:41,439 --> 04:53:43,541 ROOM IS ALSO DISCUSSIONS AROUND 7314 04:53:43,541 --> 04:53:47,011 D.E.I. AND HAVING SORT OF EQUITY 7315 04:53:47,011 --> 04:53:48,746 SPECIFICALLY INCLUDED AS A TERM, 7316 04:53:48,746 --> 04:53:50,281 ALTHOUGH I FEEL LIKE ALREADY IN 7317 04:53:50,281 --> 04:53:51,582 DESCRIBING SOME OF THIS THERE'S 7318 04:53:51,582 --> 04:53:54,585 BEEN WAYS OF FRAMING DISPARITIES 7319 04:53:54,585 --> 04:53:56,321 AS GOING FOR IMPACT OR PRECISION 7320 04:53:56,321 --> 04:53:58,022 MEDICINE AND DIFFERENT WAYS OF 7321 04:53:58,022 --> 04:53:59,123 SORT OF PUTTING LANGUAGE AROUND 7322 04:53:59,123 --> 04:54:01,993 THIS THAT MIGHT BE LESS 7323 04:54:01,993 --> 04:54:02,994 ALIENATING TO A NEW 7324 04:54:02,994 --> 04:54:03,361 ADMINISTRATION. 7325 04:54:03,361 --> 04:54:06,397 I GUESS THIS IS A LARGER 7326 04:54:06,397 --> 04:54:12,804 QUESTION BUT I'M CONCERNED THIS 7327 04:54:12,804 --> 04:54:14,839 URGENT WORK GO FORWARD IN A WAY 7328 04:54:14,839 --> 04:54:15,907 THAT'S ACCEPTABLE AND APPEAL 7329 04:54:15,907 --> 04:54:20,178 PERHAPS TO A SHIFT IN 7330 04:54:20,178 --> 04:54:21,112 PRIORITIES. 7331 04:54:21,112 --> 04:54:21,346 THANKS. 7332 04:54:21,346 --> 04:54:22,213 >> YES, THANKS, KATE. 7333 04:54:22,213 --> 04:54:25,817 HAVING LOOKED BACK AT THIS AND 7334 04:54:25,817 --> 04:54:26,884 DISCUSSED THIS WITH OTHERS ON 7335 04:54:26,884 --> 04:54:28,820 THE EXECUTIVE COMMITTEE I FEEL 7336 04:54:28,820 --> 04:54:32,190 PRETTY GOOD ABOUT THIS REPORT 7337 04:54:32,190 --> 04:54:35,593 WITH RESPECT TO THOSE CONCERNS, 7338 04:54:35,593 --> 04:54:36,027 SPECIFICALLY. 7339 04:54:36,027 --> 04:54:39,497 FIRST OF ALL, CHRONIC PAIN IS OF 7340 04:54:39,497 --> 04:54:41,099 COURSE A MAJOR DEBILITATING 7341 04:54:41,099 --> 04:54:43,034 CHRONIC CONDITION. 7342 04:54:43,034 --> 04:54:44,369 AND MANY OF THE THINGS THESE 7343 04:54:44,369 --> 04:54:47,038 PROCESS CAME UP WITH DO ALIGN 7344 04:54:47,038 --> 04:54:48,873 WELL WITH MANY OF THOSE 7345 04:54:48,873 --> 04:54:49,640 PRIORITIES. 7346 04:54:49,640 --> 04:54:52,610 I THINK THE COUNCIL CAN READ 7347 04:54:52,610 --> 04:54:55,880 THIS AND SEE, THIS IS AN 7348 04:54:55,880 --> 04:54:59,550 EXTERNAL REPORT TO NINDS, AND 7349 04:54:59,550 --> 04:55:03,087 THEY WILL, YOU KNOW, PUT THESE 7350 04:55:03,087 --> 04:55:04,021 RECOMMENDATIONS APPROPRIATELY. 7351 04:55:04,021 --> 04:55:05,490 I THINK THE GROUP WAS THOUGHTFUL 7352 04:55:05,490 --> 04:55:07,592 WITH RESPECT TO THOSE CONCERNS 7353 04:55:07,592 --> 04:55:10,294 THAT WE'RE TALKING ABOUT. 7354 04:55:10,294 --> 04:55:13,498 KATHLEEN, DID YOU WANT TO 7355 04:55:13,498 --> 04:55:13,731 ANSWER? 7356 04:55:13,731 --> 04:55:15,032 >> WHAT ROB SAID IS ABSOLUTELY 7357 04:55:15,032 --> 04:55:15,433 RIGHT. 7358 04:55:15,433 --> 04:55:18,102 WE DID WRITE INTO THE REPORT 7359 04:55:18,102 --> 04:55:21,205 RIGHT UP FRONT ACTUALLY THIS WAS 7360 04:55:21,205 --> 04:55:22,607 A CHRONIC DISEASE, PAIN IS 7361 04:55:22,607 --> 04:55:25,309 ASSOCIATED WITH MOST IF NOT MANY 7362 04:55:25,309 --> 04:55:28,179 CHRONIC DISEASES, AND IT IS A 7363 04:55:28,179 --> 04:55:30,681 MAJOR BURDEN TO THE U.S. 7364 04:55:30,681 --> 04:55:34,285 WE ALSO PUT AND HAD LONG 7365 04:55:34,285 --> 04:55:36,187 DISCUSSIONS HOW TO ADDRESS 7366 04:55:36,187 --> 04:55:37,488 DISPARITIES AND HEALTH EQUITY, 7367 04:55:37,488 --> 04:55:41,959 AND WE DIDN'T REMOVE IT. 7368 04:55:41,959 --> 04:55:43,828 WE MAY HAVE WORDSMITHED BUT 7369 04:55:43,828 --> 04:55:45,196 DIDN'T REMOVE IT. 7370 04:55:45,196 --> 04:55:46,664 AND WE KEPT THAT IN THERE 7371 04:55:46,664 --> 04:55:49,200 BECAUSE, AGAIN, IT'S AN EXTERNAL 7372 04:55:49,200 --> 04:55:50,301 REPORT AND WE THOUGHT IT WAS 7373 04:55:50,301 --> 04:55:54,639 VITALLY IMPORTANT TO KEEP IT IN. 7374 04:55:54,639 --> 04:55:59,710 SO, I WOULD BE INTERESTED TO SEE 7375 04:55:59,710 --> 04:56:00,778 THE QUESTIONS YOU ASKED GOING 7376 04:56:00,778 --> 04:56:03,114 BEYOND WHAT WE CAN DO BUT THERE 7377 04:56:03,114 --> 04:56:06,250 SHOULD BE SOME METHOD OF 7378 04:56:06,250 --> 04:56:07,485 DISSEMINATING AND SOME METHOD OF 7379 04:56:07,485 --> 04:56:08,753 HOPEFULLY IMPLEMENTING IT. 7380 04:56:08,753 --> 04:56:10,188 I JUST DON'T KNOW WHAT THAT WILL 7381 04:56:10,188 --> 04:56:11,255 BE AT THIS POINT. 7382 04:56:11,255 --> 04:56:12,957 FIRST WE HAVE TO GET IT HERE 7383 04:56:12,957 --> 04:56:23,468 BEFORE WE CAN MOVE IT TO THE 7384 04:56:32,376 --> 04:56:33,177 NEXT STAGE PROPERLY. 7385 04:56:33,177 --> 04:56:34,745 >> THERE WAS SOMETHING IN THE 7386 04:56:34,745 --> 04:56:34,946 CHAT. 7387 04:56:34,946 --> 04:56:38,249 >> I HAD A QUESTION IF I MAY. 7388 04:56:38,249 --> 04:56:39,217 VERY COMPREHENSIVE APPROACH TO 7389 04:56:39,217 --> 04:56:44,188 ALMOST THE TOTALITY OF HOW WE 7390 04:56:44,188 --> 04:56:44,989 UNDERSTAND CHRONIC DISEASE AND 7391 04:56:44,989 --> 04:56:47,558 ACUTE ASPECTS OF PAIN IN MANY 7392 04:56:47,558 --> 04:56:50,928 DIMENSIONS, THANK YOU FOR SUCH A 7393 04:56:50,928 --> 04:56:52,230 COMPREHENSIVE SORT STRATEGIC 7394 04:56:52,230 --> 04:56:53,798 PLAN. 7395 04:56:53,798 --> 04:56:55,600 MY QUESTION IS THIS. 7396 04:56:55,600 --> 04:56:56,200 YOU'VE BEEN IN EXISTENCE, THE 7397 04:56:56,200 --> 04:57:00,104 HEAL INITIATIVE HAS BEEN IN PLAY 7398 04:57:00,104 --> 04:57:02,874 FOR SEVERAL YEARS, EMPHASIZING 7399 04:57:02,874 --> 04:57:04,275 DOLLARS SPENT, 40 TRIALS, 7400 04:57:04,275 --> 04:57:05,142 SPECTACULAR. 7401 04:57:05,142 --> 04:57:07,645 IS THERE SOMEWHERE A SUMMARY OF 7402 04:57:07,645 --> 04:57:11,048 WHAT'S BEEN LEARNED, APART FROM 7403 04:57:11,048 --> 04:57:11,883 STRATEGIC PLAN? 7404 04:57:11,883 --> 04:57:18,122 I DON'T DON'T KNOW WHAT THAT I. 7405 04:57:18,122 --> 04:57:21,759 [ LOUD TONE ] 7406 04:57:21,759 --> 04:57:23,961 CAN YOU HEAR ME? 7407 04:57:23,961 --> 04:57:26,464 SO, MY QUESTION IS, IS THERE 7408 04:57:26,464 --> 04:57:28,032 SOMEWHERE A SUMMARY OF THE 7409 04:57:28,032 --> 04:57:29,267 ACTUAL CONCRETE THINGS THAT HAVE 7410 04:57:29,267 --> 04:57:31,102 BEEN ACCOMPLISHED IN TERMS OF 7411 04:57:31,102 --> 04:57:32,703 SPECIFICS OUT OF HEAL 7412 04:57:32,703 --> 04:57:33,004 INITIATIVE? 7413 04:57:33,004 --> 04:57:35,973 FOR EXAMPLE, YOU MENTIONED WHICH 7414 04:57:35,973 --> 04:57:36,874 IS SO IMPORTANT NON-ADDICTIVE 7415 04:57:36,874 --> 04:57:37,542 THERAPEUTICS AND THEIR 7416 04:57:37,542 --> 04:57:39,143 DEVELOPMENT, YOU HAVE A 7417 04:57:39,143 --> 04:57:42,313 COMMITTEE WITH 12 PEOPLE, RIGHT? 7418 04:57:42,313 --> 04:57:48,185 SO YOU ALLUDE TO ANTIBODY 7419 04:57:48,185 --> 04:57:49,887 MANAGEMENT, MAYBE NUCLEIC ACIDS, 7420 04:57:49,887 --> 04:57:56,694 SMALL MOLECULES, ION MARKERS. 7421 04:57:56,694 --> 04:57:57,828 YOU HAVE A COMMITTEE, WHAT HAVE 7422 04:57:57,828 --> 04:57:59,530 WE LEARNED? 7423 04:57:59,530 --> 04:58:01,499 AS YOU TALK ABOUT DISSEMINATING 7424 04:58:01,499 --> 04:58:02,500 TO THE GREATER PUBLIC SEEMS 7425 04:58:02,500 --> 04:58:03,801 EQUALLY IMPORTANT IS TELLING THE 7426 04:58:03,801 --> 04:58:04,835 PUBLIC WHAT HAS BEEN LEARNED SO 7427 04:58:04,835 --> 04:58:05,136 FAR. 7428 04:58:05,136 --> 04:58:09,373 SO THERE MUST BE A SUMMARY OF 7429 04:58:09,373 --> 04:58:11,142 THAT SOMEWHERE, IMPORTANT IN 7430 04:58:11,142 --> 04:58:14,111 TERMS OF JUSTIFYING DOLLARS THAT 7431 04:58:14,111 --> 04:58:14,979 ARE BEING APPROPRIATELY ENOUGH 7432 04:58:14,979 --> 04:58:16,180 BEING PUT INTO THIS. 7433 04:58:16,180 --> 04:58:19,350 >> YES, THANK YOU. 7434 04:58:19,350 --> 04:58:21,819 THERE IS. 7435 04:58:21,819 --> 04:58:22,753 THERE IS, YEAH, WALTER JUST PUT 7436 04:58:22,753 --> 04:58:26,157 THIS IN THE CHAT. 7437 04:58:26,157 --> 04:58:28,159 THERE'S AN ANNUAL REPORT FROM 7438 04:58:28,159 --> 04:58:30,394 THE HEAL INITIATIVE ON PROGRESS 7439 04:58:30,394 --> 04:58:30,828 THAT'S BEEN MADE. 7440 04:58:30,828 --> 04:58:34,665 I DON'T THINK THAT'S EASILY 7441 04:58:34,665 --> 04:58:37,068 DIGESTIBLE BY THE PUBLIC. 7442 04:58:37,068 --> 04:58:39,470 AND I THINK THAT SPEAKS TO IN 7443 04:58:39,470 --> 04:58:42,640 FACT ONE OF THE CORE PRINCIPLES 7444 04:58:42,640 --> 04:58:44,008 THIS STUFF, WE'RE ALL 7445 04:58:44,008 --> 04:58:49,246 RECOGNIZING NOW, NEEDS TO BE 7446 04:58:49,246 --> 04:58:51,148 COMMUNICATED MORE CLEARLY, AND 7447 04:58:51,148 --> 04:58:53,084 ANOTHER LINK IN THIS, IN THE 7448 04:58:53,084 --> 04:58:54,885 CHAT THERE, THAT EMPHASIZES SOME 7449 04:58:54,885 --> 04:58:56,187 OF THAT. 7450 04:58:56,187 --> 04:58:58,155 BUT HAVING THESE REPORTS DOESN'T 7451 04:58:58,155 --> 04:59:01,058 DO MUCH UNLESS THAT INFORMATION 7452 04:59:01,058 --> 04:59:01,826 GETS DISTRIBUTED. 7453 04:59:01,826 --> 04:59:06,297 AND THAT IS AN AREA OF MAJOR 7454 04:59:06,297 --> 04:59:07,431 FOCUS DISCUSSIONS WITHIN THE NIH 7455 04:59:07,431 --> 04:59:09,767 AND THERE'S -- THEY DO WHAT THEY 7456 04:59:09,767 --> 04:59:10,134 CAN. 7457 04:59:10,134 --> 04:59:11,469 THEY ARE NICE REPORTS, BUT THOSE 7458 04:59:11,469 --> 04:59:13,404 DON'T ALWAYS GET OUT THERE. 7459 04:59:13,404 --> 04:59:15,940 IT'S REALLY UP TO THE COMMUNITY, 7460 04:59:15,940 --> 04:59:19,543 RESEARCH COMMUNITY, TO BE 7461 04:59:19,543 --> 04:59:20,911 PATIENT ADVOCACY GROUPS TO DO A 7462 04:59:20,911 --> 04:59:23,514 BETTER JOB AND THERE'S A TON OF 7463 04:59:23,514 --> 04:59:30,321 DISCUSSION ABOUT HOW TO MAKE 7464 04:59:30,321 --> 04:59:30,955 THAT HAPPEN. 7465 04:59:30,955 --> 04:59:32,189 [CROSSTALK] 7466 04:59:32,189 --> 04:59:33,891 >> GIVE US A CONCRETE ACCOUNTING 7467 04:59:33,891 --> 04:59:35,426 OF YOUR ACHIEVEMENTS IN ENGLISH, 7468 04:59:35,426 --> 04:59:36,861 THAT'S WHAT I'M SAYING, YEAH. 7469 04:59:36,861 --> 04:59:38,496 THANK YOU. 7470 04:59:38,496 --> 04:59:38,796 >> AGREED. 7471 04:59:38,796 --> 04:59:39,897 >> I AGREE. 7472 04:59:39,897 --> 04:59:41,766 WE NEED TO DISSEMINATE NOT ONLY 7473 04:59:41,766 --> 04:59:49,273 TO THE SCIENTISTS BUT BACK TO 7474 04:59:49,273 --> 04:59:50,241 THE PUBLIC SOMEHOW. 7475 04:59:50,241 --> 04:59:52,043 THERE'S AN EFFORT TO GET SOME 7476 04:59:52,043 --> 04:59:53,010 THINGS OUT, MAYBE NOT SPECIFIC 7477 04:59:53,010 --> 04:59:55,279 TO "HEAL" BUT MAYBE THAT'S 7478 04:59:55,279 --> 04:59:57,148 SOMETHING WE CAN GET TO OTHERS 7479 04:59:57,148 --> 05:00:02,753 TO TRY AND DO FROM ADVOCACY 7480 05:00:02,753 --> 05:00:03,721 GROUPS. 7481 05:00:03,721 --> 05:00:06,691 I DON'T KNOW WHAT THE -- WE NEED 7482 05:00:06,691 --> 05:00:12,129 TO GET IT FARTHER DISSEMINATED. 7483 05:00:12,129 --> 05:00:12,329 LYNN? 7484 05:00:12,329 --> 05:00:16,200 >> U.S. ASSOCIATION FOR STUDY OF 7485 05:00:16,200 --> 05:00:16,967 PAIN. 7486 05:00:16,967 --> 05:00:18,135 >> I'LL SAY A COUPLE THINGS, WE 7487 05:00:18,135 --> 05:00:21,405 TALKED A LOT ABOUT THIS IN OUR 7488 05:00:21,405 --> 05:00:22,406 EXECUTIVE COMMITTEE MEETING IN 7489 05:00:22,406 --> 05:00:24,175 JANUARY ABOUT EDUCATION AND HOW 7490 05:00:24,175 --> 05:00:27,278 TO DO THAT IN A MUCH MORE ROBUST 7491 05:00:27,278 --> 05:00:27,545 WAY. 7492 05:00:27,545 --> 05:00:30,281 I KNOW UP UNTIL RECENTLY AND 7493 05:00:30,281 --> 05:00:32,583 THAT'S BEEN AFFECTED AT WELL 7494 05:00:32,583 --> 05:00:34,452 THERE WAS A COMMUNICATIONS ARM 7495 05:00:34,452 --> 05:00:36,087 OF "HEAL" THAT WAS REALLY PUT 7496 05:00:36,087 --> 05:00:40,091 TOGETHER FOR THIS PURPOSE SO I 7497 05:00:40,091 --> 05:00:41,692 THINK WHATEVER CAN BE UTILIZED 7498 05:00:41,692 --> 05:00:43,661 FROM THAT EVEN IF THAT EFFORT 7499 05:00:43,661 --> 05:00:46,397 IS, YOU KNOW, LESS ROBUST THAN 7500 05:00:46,397 --> 05:00:48,099 IT WAS IS REALLY IMPORTANT. 7501 05:00:48,099 --> 05:00:49,467 AND I THINK THINGS ARE JUST 7502 05:00:49,467 --> 05:00:51,102 STARTING TO ROLL OUT GIVEN THE 7503 05:00:51,102 --> 05:00:54,105 TIMING OF WHEN A LOT OF THESE 7504 05:00:54,105 --> 05:00:55,039 TRIALS STARTED. 7505 05:00:55,039 --> 05:00:58,442 SO IT'S A REALLY IMPORTANT 7506 05:00:58,442 --> 05:01:00,177 COMMENT, ACTIONABLE TIME. 7507 05:01:00,177 --> 05:01:01,879 THE ONLY OTHER COMMENT I WANT TO 7508 05:01:01,879 --> 05:01:04,715 MAKE, I WANT TO THANK ROB AND 7509 05:01:04,715 --> 05:01:06,584 KATHLEEN AND JACKIE WARD WHO IS 7510 05:01:06,584 --> 05:01:08,719 NOT HERE AND WALTER WHO JUST DID 7511 05:01:08,719 --> 05:01:11,055 SUCH A TREMENDOUS JOB OF THIS 7512 05:01:11,055 --> 05:01:12,690 AND I GUESS ONE OF THE THINGS I 7513 05:01:12,690 --> 05:01:20,197 WANT TO SAY I WAS IMPRESSED WITH 7514 05:01:20,197 --> 05:01:22,700 AS A MEMBER OF THE EXECUTIVE 7515 05:01:22,700 --> 05:01:24,068 COMMUNITY EVEN BEFORE BUDGETARY 7516 05:01:24,068 --> 05:01:25,269 RESTRAINTS THERE WAS SO MUCH 7517 05:01:25,269 --> 05:01:27,571 EFFORT TO LOOK AT THE SYNERGIES 7518 05:01:27,571 --> 05:01:29,874 ACROSS THESE DOMAINS OF SCIENCE 7519 05:01:29,874 --> 05:01:33,577 AND REALLY BE VERY JUDICIOUS IN 7520 05:01:33,577 --> 05:01:34,745 THE NUMBER OF RECOMMENDATIONS 7521 05:01:34,745 --> 05:01:37,214 AND WAYS WHICH THESE THINGS 7522 05:01:37,214 --> 05:01:37,815 COULD BE INTERWOVEN. 7523 05:01:37,815 --> 05:01:40,151 SO I THINK IF THERE ARE WAYS 7524 05:01:40,151 --> 05:01:42,586 THAT THESE CAN BE ACTED ON IT 7525 05:01:42,586 --> 05:01:44,955 GIVES ME MORE CONFIDENCE THAT IT 7526 05:01:44,955 --> 05:01:46,957 CAN REALLY MOVE MULTIPLE AREAS 7527 05:01:46,957 --> 05:01:48,692 OF SCIENCE FORWARD. 7528 05:01:48,692 --> 05:01:50,161 SO IT WAS JUST A TREMENDOUS 7529 05:01:50,161 --> 05:01:55,866 HONOR TO BE INVOLVED IN IT AND I 7530 05:01:55,866 --> 05:01:57,101 THINK REALLY GOOD PRODUCT. 7531 05:01:57,101 --> 05:01:59,236 >> HANK HERE. 7532 05:01:59,236 --> 05:02:01,305 THANK YOU FOR THE OVERVIEW. 7533 05:02:01,305 --> 05:02:02,540 ONE COMMENT, ONE THING WHERE YOU 7534 05:02:02,540 --> 05:02:03,841 COULD TAKE MORE ORDINARY 7535 05:02:03,841 --> 05:02:06,377 LANGUAGE TO MAKE THE SAME POINT, 7536 05:02:06,377 --> 05:02:07,745 WHEN HAVE YOU THAT MANY 7537 05:02:07,745 --> 05:02:09,847 RECOMMENDATION POINTS, SOME READ 7538 05:02:09,847 --> 05:02:15,419 IN A WONKY WAY, AS ROB SAID IT'S 7539 05:02:15,419 --> 05:02:16,187 A WONKY DESCRIPTION, ORDINARY 7540 05:02:16,187 --> 05:02:17,521 LANGUAGE THOSE THINGS TO BE 7541 05:02:17,521 --> 05:02:18,989 UNDERSTANDABLE TO THE SCIENTIFIC 7542 05:02:18,989 --> 05:02:20,858 COMMUNITY AND NIH BUT BEYOND. 7543 05:02:20,858 --> 05:02:22,860 I TOOK THIS TIME TO LOOK THROUGH 7544 05:02:22,860 --> 05:02:26,263 THE 2024 REPORT. 7545 05:02:26,263 --> 05:02:27,464 IT READS VERY WELL. 7546 05:02:27,464 --> 05:02:29,099 THE QUESTION IS WHO DOES SEE 7547 05:02:29,099 --> 05:02:30,134 THAT REPORT? 7548 05:02:30,134 --> 05:02:32,503 WHAT ASPECTS OF THE REPORT ARE 7549 05:02:32,503 --> 05:02:37,308 EXTRACTED AND SENT TO THE 7550 05:02:37,308 --> 05:02:37,541 PUBLIC? 7551 05:02:37,541 --> 05:02:38,843 WALTER MENTIONED OPIOIDS, LAST 7552 05:02:38,843 --> 05:02:41,579 NEWS IN THE LAST COUPLE DAYS BUT 7553 05:02:41,579 --> 05:02:44,415 I DON'T SEE BIG NEWS ABOUT 7554 05:02:44,415 --> 05:02:46,550 IMPACTS OF PAIN INITIATIVE WORK. 7555 05:02:46,550 --> 05:02:48,219 IT'S NOT YOUR FAULT, JUST WE 7556 05:02:48,219 --> 05:02:49,520 DON'T HAVE A COMMUNICATIONS TEAM 7557 05:02:49,520 --> 05:02:51,822 TO DO THAT. 7558 05:02:51,822 --> 05:02:54,458 IS THE ANNUAL REPORT SEEN BY THE 7559 05:02:54,458 --> 05:02:58,429 POPULATIONS YOU WANT TO HAVE SEE 7560 05:02:58,429 --> 05:02:59,029 IT? 7561 05:02:59,029 --> 05:03:00,998 >> NO. 7562 05:03:00,998 --> 05:03:06,036 >> NO, IT NEEDS TO BE, YOU'RE 7563 05:03:06,036 --> 05:03:09,173 RIGHT, HANK. 7564 05:03:09,173 --> 05:03:11,675 TOTALLY NEEDS TO BE. 7565 05:03:11,675 --> 05:03:14,144 THROUGHOUT THE COMMITTEE WE 7566 05:03:14,144 --> 05:03:16,180 TALKED ABOUT HOW POOR A JOB 7567 05:03:16,180 --> 05:03:16,480 WE'VE DONE. 7568 05:03:16,480 --> 05:03:18,916 THAT HAS TO COME FROM MULTIPLE 7569 05:03:18,916 --> 05:03:21,085 SOURCES, NIH MAYBE NEEDS TO DO A 7570 05:03:21,085 --> 05:03:22,286 BETTER JOB COMMUNICATING 7571 05:03:22,286 --> 05:03:24,188 REPORTS, AND AS A COMMUNITY WE 7572 05:03:24,188 --> 05:03:26,390 NEED TO PICK IT UP AND PUSH IT 7573 05:03:26,390 --> 05:03:28,659 OUT AS WELL. 7574 05:03:28,659 --> 05:03:29,927 AND WE HAVEN'T. 7575 05:03:29,927 --> 05:03:31,495 WE SPENT THE LAST 20 YEARS 7576 05:03:31,495 --> 05:03:33,030 TRYING TO GET FUNDING TO IMPROVE 7577 05:03:33,030 --> 05:03:34,865 PAIN RESEARCH AND WE FINALLY GOT 7578 05:03:34,865 --> 05:03:36,533 THERE SO NOW WE'RE ON THE NEXT 7579 05:03:36,533 --> 05:03:41,105 PAGE I THINK IS HOW TO GET IT 7580 05:03:41,105 --> 05:03:41,372 OUT THERE. 7581 05:03:41,372 --> 05:03:42,439 A GOOD COMMENT. 7582 05:03:42,439 --> 05:03:44,508 >> THERE'S A LOT OF ENERGY, 7583 05:03:44,508 --> 05:03:48,178 HANK, AROUND MAKING SURE THAT WE 7584 05:03:48,178 --> 05:03:51,715 DON'T JUST PUBLISH A PAPER AND 7585 05:03:51,715 --> 05:03:54,385 SAY, AH, THERE, DONE, MISSION 7586 05:03:54,385 --> 05:03:55,352 ACCOMPLISHED. 7587 05:03:55,352 --> 05:03:56,654 IT'S A PUBLIC CAMPAIGN. 7588 05:03:56,654 --> 05:03:59,723 BEYOND THE PURVIEW OF NIH, 7589 05:03:59,723 --> 05:04:01,125 ACTUALLY, BUT WE NEED TO TAKE 7590 05:04:01,125 --> 05:04:02,793 THAT AS A COMMUNITY AND FIND A 7591 05:04:02,793 --> 05:04:07,564 WAY TO DO THAT. 7592 05:04:07,564 --> 05:04:12,269 BROADLY, NOT JUST FOR PAIN. 7593 05:04:12,269 --> 05:04:12,636 >> YEAH. 7594 05:04:12,636 --> 05:04:14,838 I THINK THIS IS A SYMPTOM OF 7595 05:04:14,838 --> 05:04:16,340 WHAT WE TALKED ABOUT EARLIER, IN 7596 05:04:16,340 --> 05:04:18,876 TERMS OF MESSAGING THE VALUE OF 7597 05:04:18,876 --> 05:04:19,843 THE RESEARCH. 7598 05:04:19,843 --> 05:04:30,387 I WOULD JUST BE HONEST THAT NIH 7599 05:04:30,621 --> 05:04:31,889 IS THE WEAKEST PARTNER AT THIS 7600 05:04:31,889 --> 05:04:33,624 TIME, PROBABLY WEAKER THAN EVER 7601 05:04:33,624 --> 05:04:33,857 BEFORE. 7602 05:04:33,857 --> 05:04:37,361 WE HAVE TO RELY ON TRUSTED 7603 05:04:37,361 --> 05:04:38,095 SPOKESFOLKS. 7604 05:04:38,095 --> 05:04:39,863 IN TERMS OF THE HEAL INITIATIVE 7605 05:04:39,863 --> 05:04:42,967 WE DID THE NEUROBIOLOGY DISEASE 7606 05:04:42,967 --> 05:04:44,201 COURSE, CLIFFORD WOOLF GAVE A 7607 05:04:44,201 --> 05:04:45,402 TALK ON PAIN. 7608 05:04:45,402 --> 05:04:46,403 THINGS HAVE JUST EXPLODED IN 7609 05:04:46,403 --> 05:04:50,207 TERMS OF THE SCIENCE OF PAIN AND 7610 05:04:50,207 --> 05:04:52,543 CLIFFORD CERTAINLY HAD A LOT TO 7611 05:04:52,543 --> 05:04:57,247 DO WITH IT BUT THEN THERE'S 7612 05:04:57,247 --> 05:04:57,881 POTENTIALLY BREAKTHROUGHS, 7613 05:04:57,881 --> 05:04:58,649 COMPANIES WERE NEVER INTERESTED, 7614 05:04:58,649 --> 05:04:59,950 HAVE NOT BEEN INTERESTED IN PAIN 7615 05:04:59,950 --> 05:05:03,287 FOR A LONG TIME BECAUSE OF ALL 7616 05:05:03,287 --> 05:05:07,057 THE FAILURES BUT THERE'S BEEN 7617 05:05:07,057 --> 05:05:09,159 RECENT BREAKTHROUGHS THERE, AND 7618 05:05:09,159 --> 05:05:11,528 IT WAS ALL BASED ON BASIC 7619 05:05:11,528 --> 05:05:16,033 SCIENCE THAT THEY PICKED UP ON 7620 05:05:16,033 --> 05:05:18,702 AND WE HAVE PROJECTS HERE TO GET 7621 05:05:18,702 --> 05:05:22,740 THINGS TO PATIENTS, THOSE ALSO I 7622 05:05:22,740 --> 05:05:24,241 THINK ARE LOOKING PROMISING. 7623 05:05:24,241 --> 05:05:26,243 SO WE HAVE A GOOD STORY. 7624 05:05:26,243 --> 05:05:31,382 WE'RE NOT SELLING BAD GOODS 7625 05:05:31,382 --> 05:05:31,682 HERE, GUYS. 7626 05:05:31,682 --> 05:05:33,450 WE'RE NOT MAKING ANYTHING UP. 7627 05:05:33,450 --> 05:05:36,720 WE HAVE FIGURE OUT HOW TO LET 7628 05:05:36,720 --> 05:05:40,891 PEOPLE UNDERSTAND PARTICULARLY 7629 05:05:40,891 --> 05:05:42,493 PEOPLE HAVE BAD PAIN, IT'S HARD 7630 05:05:42,493 --> 05:05:43,594 TO BE ENTHUSIASTIC WHEN WE DON'T 7631 05:05:43,594 --> 05:05:45,896 HAVE SOMETHING FOR THE PERSON IN 7632 05:05:45,896 --> 05:05:46,930 FRONT OF YOU. 7633 05:05:46,930 --> 05:05:52,102 BUT I THINK WE'RE DEFINITELY 7634 05:05:52,102 --> 05:06:02,413 MAKING PROGRESS. 7635 05:06:03,647 --> 05:06:05,749 >> IF YOU KNOW WHAT THE SOUND 7636 05:06:05,749 --> 05:06:07,851 IS, CUT IT OFF. 7637 05:06:07,851 --> 05:06:08,585 >> YEAH, EXACTLY. 7638 05:06:08,585 --> 05:06:12,990 >> DO WE HAVE ANY ADDITIONAL 7639 05:06:12,990 --> 05:06:16,560 QUESTIONS OR COMMENTS REGARDING 7640 05:06:16,560 --> 05:06:22,566 THIS PRESENTATION? 7641 05:06:22,566 --> 05:06:22,766 OKAY. 7642 05:06:22,766 --> 05:06:27,137 SO, WE NEED TO APPROVE THESE 7643 05:06:27,137 --> 05:06:27,504 RECOMMENDATIONS. 7644 05:06:27,504 --> 05:06:38,015 CAN I GET A MOTION TO APPROVE? 7645 05:06:39,516 --> 05:06:44,188 >> I'LL MAKE THE MOTION IF 7646 05:06:44,188 --> 05:06:45,689 NOBODY ELSE WILL. 7647 05:06:45,689 --> 05:06:47,991 >> I'LL SECOND IT. 7648 05:06:47,991 --> 05:06:49,059 >> WHOEVER IS WASHING THEIR 7649 05:06:49,059 --> 05:06:56,433 HANDS ... OR WAS THAT OUR MOTION 7650 05:06:56,433 --> 05:06:58,936 TO APPROVE? 7651 05:06:58,936 --> 05:07:00,471 DID SOMEONE MOTION? 7652 05:07:00,471 --> 05:07:02,673 >> FROM LOUISE AND THEN I 7653 05:07:02,673 --> 05:07:02,940 SECONDED. 7654 05:07:02,940 --> 05:07:03,440 >> THANK YOU. 7655 05:07:03,440 --> 05:07:07,744 THAT WAS COVERED UP BY THE HAND 7656 05:07:07,744 --> 05:07:10,547 WASHING. 7657 05:07:10,547 --> 05:07:10,747 OKAY. 7658 05:07:10,747 --> 05:07:15,052 SO, AGAIN, AUDIBLE VOTE. 7659 05:07:15,052 --> 05:07:15,219 BOB? 7660 05:07:15,219 --> 05:07:17,121 >> YES. 7661 05:07:17,121 --> 05:07:17,454 >> YISHI? 7662 05:07:17,454 --> 05:07:20,224 >> YES. 7663 05:07:20,224 --> 05:07:20,791 >> JANE? 7664 05:07:20,791 --> 05:07:21,492 >> YES. 7665 05:07:21,492 --> 05:07:23,127 >> JIN MU. 7666 05:07:23,127 --> 05:07:24,461 >> APPROVE. 7667 05:07:24,461 --> 05:07:27,498 >> JOHN? 7668 05:07:27,498 --> 05:07:27,831 >> APPROVE. 7669 05:07:27,831 --> 05:07:30,601 >> LOUISE? 7670 05:07:30,601 --> 05:07:32,136 >> APPROVE. 7671 05:07:32,136 --> 05:07:32,402 >> HANK? 7672 05:07:32,402 --> 05:07:36,073 >> APPROVE. 7673 05:07:36,073 --> 05:07:38,542 >> THANK YOU. 7674 05:07:38,542 --> 05:07:38,742 OKAY. 7675 05:07:38,742 --> 05:07:40,244 NEXT UP, I WANT TO MAKE A 7676 05:07:40,244 --> 05:07:42,179 MENTION WE HAVE TWO MORE ITEMS 7677 05:07:42,179 --> 05:07:44,214 ON THE AGENDA, A CONCEPT 7678 05:07:44,214 --> 05:07:46,183 CLEARANCE AND A PUBLIC COMMENT. 7679 05:07:46,183 --> 05:07:48,218 AND WE'RE A LITTLE BEHIND 7680 05:07:48,218 --> 05:07:48,552 SCHEDULE. 7681 05:07:48,552 --> 05:07:50,854 SO WE WERE THINKING OF JUST 7682 05:07:50,854 --> 05:07:52,689 BREAKING AT THE END OF THE OPEN 7683 05:07:52,689 --> 05:07:56,760 SESSION AND DOING THE CLOSED 7684 05:07:56,760 --> 05:07:58,128 SESSION TOMORROW. 7685 05:07:58,128 --> 05:07:58,529 I'M SEEING NODS. 7686 05:07:58,529 --> 05:08:03,000 IS THAT OKAY WITH YOU, WALTER? 7687 05:08:03,000 --> 05:08:05,536 >> THAT'S FINE WITH ME. 7688 05:08:05,536 --> 05:08:05,802 >> OKAY. 7689 05:08:05,802 --> 05:08:06,703 THAT'S THE EASIEST DIVISION. 7690 05:08:06,703 --> 05:08:09,406 SO LET'S JUMP INTO THIS CONCEPT 7691 05:08:09,406 --> 05:08:09,973 CLEARANCE. 7692 05:08:09,973 --> 05:08:12,676 AS YOU KNOW BEFORE WE LAUNCH A 7693 05:08:12,676 --> 05:08:14,344 NEW INITIATIVE WE'VE ASK COUNCIL 7694 05:08:14,344 --> 05:08:15,913 FOR CONCEPT CLEARANCE AND AS I 7695 05:08:15,913 --> 05:08:18,282 MENTIONED PREVIOUSLY THERE'S A 7696 05:08:18,282 --> 05:08:21,285 NEW APPROVAL PROCESS FOR THIS 7697 05:08:21,285 --> 05:08:23,453 REQUIRING BOTH NIH AND HHS LEVEL 7698 05:08:23,453 --> 05:08:26,456 CLEARANCE BEFORE THEY CAN COME 7699 05:08:26,456 --> 05:08:28,025 TO COUNCIL. 7700 05:08:28,025 --> 05:08:29,359 ACTUALLY FOR THE HHS LEVEL IT'S 7701 05:08:29,359 --> 05:08:31,695 NOT GOING TO BE REQUIRED BEFORE 7702 05:08:31,695 --> 05:08:35,299 THINGS COME TO COUNCIL, THAT WAS 7703 05:08:35,299 --> 05:08:38,802 A NEW MOVE LAST WEEK. 7704 05:08:38,802 --> 05:08:41,371 BUT IN GENERAL WE'RE TRYING TO 7705 05:08:41,371 --> 05:08:44,441 ALIGN THE CONCEPTS THAT WE PUT 7706 05:08:44,441 --> 05:08:46,410 BEFORE YOU WITH NIH PRIORITIES 7707 05:08:46,410 --> 05:08:49,846 BEFORE THEY ARE IN COUNCIL. 7708 05:08:49,846 --> 05:08:51,181 AND BECAUSE OF THIS NEW PROCESS 7709 05:08:51,181 --> 05:08:53,750 WE ONLY HAVE ONE CONCEPT TO 7710 05:08:53,750 --> 05:08:58,555 APPROVE TODAY, WHICH IS U24 BIO 7711 05:08:58,555 --> 05:09:00,224 AND DATA REPOSITORY. 7712 05:09:00,224 --> 05:09:02,426 WE TYPICALLY DON'T DISCUSS THESE 7713 05:09:02,426 --> 05:09:03,527 UNLESS THERE'S SIGNIFICANT 7714 05:09:03,527 --> 05:09:06,230 CHANGES THAT ARE BEING PROPOSED. 7715 05:09:06,230 --> 05:09:07,664 OR IF THERE'S SOMETHING THAT 7716 05:09:07,664 --> 05:09:09,366 ANYONE WANTS TO CALL ATTENTION 7717 05:09:09,366 --> 05:09:12,269 TO, ARE THERE ANY QUESTIONS OR 7718 05:09:12,269 --> 05:09:13,837 CONCERNS ABOUT THE CONCEPT THAT 7719 05:09:13,837 --> 05:09:23,180 YOU SEE IN YOUR ECB? 7720 05:09:23,180 --> 05:09:23,513 OKAY. 7721 05:09:23,513 --> 05:09:25,382 HEARING NONE, THEN WE WILL VOTE 7722 05:09:25,382 --> 05:09:26,316 ON THE CONCEPT. 7723 05:09:26,316 --> 05:09:32,222 CAN I HAVE A MOTION TO APPROVE 7724 05:09:32,222 --> 05:09:36,126 IT? 7725 05:09:36,126 --> 05:09:36,593 >> (INAUDIBLE). 7726 05:09:36,593 --> 05:09:37,961 >> I'LL TAKE THAT. 7727 05:09:37,961 --> 05:09:39,596 >> I SECOND. 7728 05:09:39,596 --> 05:09:40,964 >> SECOND, THANK YOU. 7729 05:09:40,964 --> 05:09:42,699 BOB? 7730 05:09:42,699 --> 05:09:44,334 >> YES. 7731 05:09:44,334 --> 05:09:47,004 >> YISHI? 7732 05:09:47,004 --> 05:09:47,838 >> YES. 7733 05:09:47,838 --> 05:09:48,105 >> JANE? 7734 05:09:48,105 --> 05:09:49,573 >> YES. 7735 05:09:49,573 --> 05:09:51,341 >> JIN MU. 7736 05:09:51,341 --> 05:09:52,576 >> APPROVED. 7737 05:09:52,576 --> 05:09:54,611 >> JOHN? 7738 05:09:54,611 --> 05:09:56,213 >> APPROVE. 7739 05:09:56,213 --> 05:09:56,713 >> LOUISE. 7740 05:09:56,713 --> 05:09:58,415 >> APPROVE. 7741 05:09:58,415 --> 05:09:58,715 >> HANK. 7742 05:09:58,715 --> 05:10:02,286 >> APPROVE. 7743 05:10:02,286 --> 05:10:03,153 >> OKAY. 7744 05:10:03,153 --> 05:10:03,854 THANK YOU. 7745 05:10:03,854 --> 05:10:07,524 BEFORE WE ADJOURN WE HAVE THE 7746 05:10:07,524 --> 05:10:08,425 PUBLIC COMMENT. 7747 05:10:08,425 --> 05:10:10,060 SO THIS IS A SUBMISSION IN THE 7748 05:10:10,060 --> 05:10:13,063 FORM OF A LETTER FROM DR. JARROD 7749 05:10:13,063 --> 05:10:14,998 BAILEY, DIRECTOR OF MEDICAL 7750 05:10:14,998 --> 05:10:17,701 RESEARCH FROM THE PHYSICIANS 7751 05:10:17,701 --> 05:10:20,971 COMMITTEE FOR RESPONSIBLE 7752 05:10:20,971 --> 05:10:21,305 MEDICINE. 7753 05:10:21,305 --> 05:10:24,708 YOU CAN FIND THIS IN THE ECB. 7754 05:10:24,708 --> 05:10:29,446 HE WRITES ON BEE BEHALF OF THE 7755 05:10:29,446 --> 05:10:32,916 COMMITTEE TO COMMENT ON SUPPORT 7756 05:10:32,916 --> 05:10:35,852 FOR HUMAN BASED NON-ANIMAL BASED 7757 05:10:35,852 --> 05:10:36,353 APPROACHES SPECIFICALLY 7758 05:10:36,353 --> 05:10:38,789 COMMENTING ON THOSE LAUNCHED IN 7759 05:10:38,789 --> 05:10:41,992 2024 WITH THE COMPLEMENT ANIMAL 7760 05:10:41,992 --> 05:10:42,726 RESEARCH AND EXPERIMENTATION 7761 05:10:42,726 --> 05:10:45,929 COMMON FUND PROGRAM WHICH 7762 05:10:45,929 --> 05:10:46,596 ACCELERATES DEVELOPMENT, 7763 05:10:46,596 --> 05:10:47,898 STANDARDIZATION, VALIDATION, AND 7764 05:10:47,898 --> 05:10:50,400 USE OF NEW APPROACH 7765 05:10:50,400 --> 05:10:51,068 METHODOLOGIES. 7766 05:10:51,068 --> 05:10:56,206 AND ALSO THE APRIL 29, 2025, NIH 7767 05:10:56,206 --> 05:10:58,141 INITIATIVE TO PRIORITIZE 7768 05:10:58,141 --> 05:10:58,909 HUMAN-BASED RESEARCH 7769 05:10:58,909 --> 05:11:00,277 TECHNOLOGIES WHILE REDUCING 7770 05:11:00,277 --> 05:11:01,978 ANIMAL USE. 7771 05:11:01,978 --> 05:11:03,880 THE LETTER RECOMMENDS THAT NINDS 7772 05:11:03,880 --> 05:11:07,884 BUILD ON THESE NIH EFFORTS BY 7773 05:11:07,884 --> 05:11:09,419 PRIORITIZING DEVELOPMENT AND USE 7774 05:11:09,419 --> 05:11:11,421 OF HUMAN-BASED METHODS FOR 7775 05:11:11,421 --> 05:11:12,923 NEUROLOGICAL RESEARCH AND NUMBER 7776 05:11:12,923 --> 05:11:15,892 TWO, PHASING OUT USE OF 7777 05:11:15,892 --> 05:11:19,162 NON-HUMAN PRIMATES IN 7778 05:11:19,162 --> 05:11:21,298 NEUROLOGICAL RESEARCH. 7779 05:11:21,298 --> 05:11:24,201 DO WE HAVE ANY QUESTIONS OR 7780 05:11:24,201 --> 05:11:26,870 COMMENTS ABOUT THE PUBLIC 7781 05:11:26,870 --> 05:11:34,778 COMMENT? 7782 05:11:34,778 --> 05:11:35,712 OKAY. 7783 05:11:35,712 --> 05:11:39,716 HEARING NONE, THIS CONCLUDES OUR 7784 05:11:39,716 --> 05:11:40,217 OPEN SESSION. 7785 05:11:40,217 --> 05:11:41,852 WE'RE ADJOURNED. 7786 05:11:41,852 --> 05:12:08,845 AND WE WILL RECONVENE TOMORROROR