1 00:00:06,776 --> 00:00:07,377 >> WELCOME EVERYBODY TO THE 2 00:00:07,377 --> 00:00:10,180 27th MEETING OF THE BRAIN 3 00:00:10,180 --> 00:00:11,681 MULTI-COUNCIL WORKING GROUP. 4 00:00:11,681 --> 00:00:13,116 I'M A WEISS WISE AND I'M THE 5 00:00:13,116 --> 00:00:15,185 DIRECTOR OF THE DIVISION OF 6 00:00:15,185 --> 00:00:18,989 EXTRAMURAL RESEARCH -- WISE. 7 00:00:18,989 --> 00:00:22,292 AND I'M HERE TODAY SERVING AS A 8 00:00:22,292 --> 00:00:23,293 DESIGNATED FEDERAL OFFICIAL FOR 9 00:00:23,293 --> 00:00:24,761 THE BRAIN MULTI-COUNCIL WORKING 10 00:00:24,761 --> 00:00:25,161 GROUP. 11 00:00:25,161 --> 00:00:27,197 WE HAVE A FEW NEW PEOPLE JOINING 12 00:00:27,197 --> 00:00:30,500 US TODAY SO I WANT TO BRIEFLY 13 00:00:30,500 --> 00:00:32,669 REMIND YOU THAT NCWG IS NOT A 14 00:00:32,669 --> 00:00:34,638 FORMAL ADVISORY GROUP UNDER THE 15 00:00:34,638 --> 00:00:35,505 FEDERAL ADVISORY COMMITTEE 16 00:00:35,505 --> 00:00:35,705 ACTED. 17 00:00:35,705 --> 00:00:38,775 IT IS IN FACT AN ADVISORY GROUP 18 00:00:38,775 --> 00:00:41,378 TO THE 10 ADVISORY COUNCILS OF 19 00:00:41,378 --> 00:00:42,979 THE PARTICIPATING BRAIN 20 00:00:42,979 --> 00:00:45,048 INSTITUTES AND CENTERS. 21 00:00:45,048 --> 00:00:46,783 IT WAS ESTABLISHED EARLY ON 22 00:00:46,783 --> 00:00:48,451 BECAUSE OF THE RECOGNIZED NEED 23 00:00:48,451 --> 00:00:50,687 FOR DIVERSE EXPERTISE IN VARIOUS 24 00:00:50,687 --> 00:00:52,589 DISCIPLINES IN ORDER TO PROPERLY 25 00:00:52,589 --> 00:00:54,658 ASSESS AND OVERSEE THE RESEARCH 26 00:00:54,658 --> 00:00:56,760 THAT IS BEING UNDERTAKEN THROUGH 27 00:00:56,760 --> 00:00:58,194 THE BRAIN INITIATIVE. 28 00:00:58,194 --> 00:01:00,797 SOME OF OUR MEMBERS ARE FROM THE 29 00:01:00,797 --> 00:01:02,565 INSTITUTE AND CENTER ADVISORY 30 00:01:02,565 --> 00:01:04,768 COUNCILS AND WE ALSO HAVE SOME 31 00:01:04,768 --> 00:01:06,670 AT LARGE MEMBERS WHO HAVE BEEN 32 00:01:06,670 --> 00:01:07,537 APPOINTED TO SUPPLEMENT THE 33 00:01:07,537 --> 00:01:09,673 WORKING GROUP'S EXPERTISE. 34 00:01:09,673 --> 00:01:12,976 WE ALSO HAVE SEVERAL EX-OFFICIO 35 00:01:12,976 --> 00:01:15,478 MEMBERS, OTHER PARTNERS OF NIH'S 36 00:01:15,478 --> 00:01:19,883 AND THESE ARE FROM DARPA, THE 37 00:01:19,883 --> 00:01:23,586 FDA, IARPA AND NSF. 38 00:01:23,586 --> 00:01:26,756 WE DEPEND ON THEM FOR THE 39 00:01:26,756 --> 00:01:28,158 ONGOING OVERSIGHT OF THE 40 00:01:28,158 --> 00:01:29,359 PROGRESS OF THE BRAIN 41 00:01:29,359 --> 00:01:30,760 INITIATIVE, FOR FEEDBACK ON 42 00:01:30,760 --> 00:01:32,295 CONCEPT CLEARANCES AND INPUT ON 43 00:01:32,295 --> 00:01:33,863 OUR FUNDING PLANS DURING THE 44 00:01:33,863 --> 00:01:35,198 CLOSED SESSION. 45 00:01:35,198 --> 00:01:37,100 THE OPEN SESSION IS BEING 46 00:01:37,100 --> 00:01:38,335 VIDEOCAST AND RECORDED AND WILL 47 00:01:38,335 --> 00:01:41,771 BE ARCHIVED AND POSTED ON THE 48 00:01:41,771 --> 00:01:43,306 NIH BRAIN WEBSITE. 49 00:01:43,306 --> 00:01:45,075 TODAY WE ARE GOING TO BEGIN WITH 50 00:01:45,075 --> 00:01:47,310 AN UPDATE ON THE NEUROETHICS 51 00:01:47,310 --> 00:01:47,911 WORKING GROUP. 52 00:01:47,911 --> 00:01:49,379 WE'LL HEAR A LITTLE BIT ABOUT 53 00:01:49,379 --> 00:01:51,581 YESTERDAY'S MEETING AND OTHER 54 00:01:51,581 --> 00:01:53,183 ACTIVITIES, IF ANY OF YOU DIDN'T 55 00:01:53,183 --> 00:01:54,684 SEE YESTERDAY'S MEETING, IT WAS 56 00:01:54,684 --> 00:01:57,287 REALLY FASCINATING AND I WAS 57 00:01:57,287 --> 00:01:58,788 RECOMMEND THAT YOU LISTEN TO IT 58 00:01:58,788 --> 00:02:00,590 WHEN IT DOES GET POSTING. 59 00:02:00,590 --> 00:02:02,359 WE'LL HEAR AFTER THAT, FROM OUR 60 00:02:02,359 --> 00:02:05,495 BRAIN INITIATIVE DIRECTOR, 61 00:02:05,495 --> 00:02:07,497 DR. JOHN GNAI WHO WILL DISCUSS 62 00:02:07,497 --> 00:02:08,531 THE CURRENT STATE OF THE 63 00:02:08,531 --> 00:02:09,799 INITIATIVE AND AFTER THAT, WE 64 00:02:09,799 --> 00:02:11,368 ARE FORTUNATE TO HAVE ALYSSA 65 00:02:11,368 --> 00:02:14,604 PICCHINI SCHAFFER WITH US, THE 66 00:02:14,604 --> 00:02:15,505 VICE PRESIDENT AND SENIOR 67 00:02:15,505 --> 00:02:16,172 SCIENTIST AT THE SIMON'S 68 00:02:16,172 --> 00:02:17,774 FOUNDATION AND SHE WILL PROVIDE 69 00:02:17,774 --> 00:02:20,009 AN OVERVIEW OF THEIR CURRENT 70 00:02:20,009 --> 00:02:22,178 NEUROSCIENCE PORTFOLIO. 71 00:02:22,178 --> 00:02:23,847 SIMON'S FOUNDATION IS ONE OF OUR 72 00:02:23,847 --> 00:02:25,515 BRAIN INITIATIVE ALLIANCE 73 00:02:25,515 --> 00:02:27,951 PARTNERS AND IS THE NEW CO-CHAIR 74 00:02:27,951 --> 00:02:29,419 OF THE BRAIN INITIATIVE 75 00:02:29,419 --> 00:02:31,187 ALLIANCE, ALONGSIDE NIH AND WE 76 00:02:31,187 --> 00:02:33,623 WELCOME ALESSA AS OUR NEW 77 00:02:33,623 --> 00:02:35,158 REPRESENTATIVE TO THE 78 00:02:35,158 --> 00:02:36,926 MULTI-COUNCIL WORKING GROUP. 79 00:02:36,926 --> 00:02:39,696 IN ADDITION TO ALYSSA, WE ALSO 80 00:02:39,696 --> 00:02:41,998 WELCOME DR. FERID MURAD FROM 81 00:02:41,998 --> 00:02:43,900 OHIO STATE UNIVERSITY WHO IS 82 00:02:43,900 --> 00:02:46,202 SERVING AS THE NIDCD 83 00:02:46,202 --> 00:02:47,904 REPRESENTATIVE AND HE WILL BE 84 00:02:47,904 --> 00:02:50,673 TAKING OVER FROM DR. DAN SANES 85 00:02:50,673 --> 00:02:53,109 WHO HAS SERVED FOR THE LAST 86 00:02:53,109 --> 00:02:55,845 THREE YEARS. 87 00:02:55,845 --> 00:02:57,614 WE ALSO WELCOME ADAM WILLIS WHO 88 00:02:57,614 --> 00:02:59,883 IS SERVING AS OUR NEW DARPA 89 00:02:59,883 --> 00:03:00,617 EX-OFFICIO MEMBERS. 90 00:03:00,617 --> 00:03:02,986 AND THEY WILL BE OFFICIALLY 91 00:03:02,986 --> 00:03:06,122 ACKNOWLEDGED BY JOHN DURING HIS 92 00:03:06,122 --> 00:03:08,391 PRESENTATION. 93 00:03:08,391 --> 00:03:09,192 FOLLOWING OPEN SESSION WE WILL 94 00:03:09,192 --> 00:03:11,361 HAVE A 30-MINUTE BREAK BEFORE 95 00:03:11,361 --> 00:03:13,997 CLOSED SESSION AND I'LL GO OVER 96 00:03:13,997 --> 00:03:15,331 OUR CLOSED SESSION OPERATING 97 00:03:15,331 --> 00:03:16,199 PROCEDURES AT THAT TIME. 98 00:03:16,199 --> 00:03:18,601 WE EXPECT THAT TO START AROUND 99 00:03:18,601 --> 00:03:19,002 2:30. 100 00:03:19,002 --> 00:03:21,204 THERE IS A DIFFERENT ZOOM LINK 101 00:03:21,204 --> 00:03:22,605 FOR THE CLOSED SESSION AND THAT 102 00:03:22,605 --> 00:03:24,374 IS FOR ONLY MEMBERS OF THE 103 00:03:24,374 --> 00:03:25,642 WORKING GROUP AND GOVERNMENT 104 00:03:25,642 --> 00:03:25,909 EMPLOYEES. 105 00:03:25,909 --> 00:03:27,510 A COUPLE OF HOUSEKEEPING ITEMS. 106 00:03:27,510 --> 00:03:30,113 WHEN NOT SPEAKING, PLEASE MUTE 107 00:03:30,113 --> 00:03:30,914 YOUR LINE. 108 00:03:30,914 --> 00:03:32,315 DURING DISCUSSIONS, PLEASE MAKE 109 00:03:32,315 --> 00:03:34,617 SURE THAT YOUR VIDEO IS ON AND 110 00:03:34,617 --> 00:03:36,820 USE THE RAISE HAND OPTION IF YOU 111 00:03:36,820 --> 00:03:37,821 HAVE QUESTIONS. 112 00:03:37,821 --> 00:03:40,023 WE'LL CALL ON YOU TO UNMUTE 113 00:03:40,023 --> 00:03:40,290 YOURSELF. 114 00:03:40,290 --> 00:03:41,825 BECAUSE THIS IS AN OPEN SESSION, 115 00:03:41,825 --> 00:03:43,793 AND IT'S BEING VIDEOCAST, WE 116 00:03:43,793 --> 00:03:45,428 PREFER YOU NOT USE THE CHAT 117 00:03:45,428 --> 00:03:46,830 FUNCTION FOR DISCUSSIONS SINCE 118 00:03:46,830 --> 00:03:48,898 IT'S NOT VISIBLE THROUGH THE 119 00:03:48,898 --> 00:03:49,165 VIDEOCAST. 120 00:03:49,165 --> 00:03:52,836 AND FINALLY, I WANT TO THANK THE 121 00:03:52,836 --> 00:03:54,504 OUTSTANDING TEAM WHOSE HARD WORK 122 00:03:54,504 --> 00:03:56,105 GOES INTO PREPARING FOR THIS 123 00:03:56,105 --> 00:03:58,608 MEETING AS WELL AS OUR COMPANION 124 00:03:58,608 --> 00:03:59,909 NEUROETHICS MEETING YESTERDAY. 125 00:03:59,909 --> 00:04:05,648 IN PARTICULAR, DR. KRISTIN 126 00:04:05,648 --> 00:04:08,518 DUPREE, DR. NINA SHOE, MICHELLE 127 00:04:08,518 --> 00:04:09,986 PEARSON AND DR. HENDRICKS. 128 00:04:09,986 --> 00:04:12,121 NOT ONLY ARE THEY INCREDIBLY 129 00:04:12,121 --> 00:04:13,823 EFFICIENT AND THOROUGH, BUT THEY 130 00:04:13,823 --> 00:04:15,425 ARE A PLEASURE TO WORK WITH AS 131 00:04:15,425 --> 00:04:17,460 MOST OF YOU ALREADY KNOW AND I'M 132 00:04:17,460 --> 00:04:19,996 VERY GRATEFUL FOR THEIR HELP. 133 00:04:19,996 --> 00:04:21,731 IF ANYONE IS HAVING TECHNICAL 134 00:04:21,731 --> 00:04:24,267 PROBLEMS, PLEASE E-MAIL KRISTIN 135 00:04:24,267 --> 00:04:26,002 OR DEB AND THEY AND THEIR TEAM 136 00:04:26,002 --> 00:04:27,437 WILL HELP SORT THINGS OUT FOR 137 00:04:27,437 --> 00:04:27,904 YOU. 138 00:04:27,904 --> 00:04:33,243 I'M GOING TO TURN IT OVER NOW TO 139 00:04:33,243 --> 00:04:40,750 JOHN FARA NINA WHO WILL SUMMARIE 140 00:04:40,750 --> 00:04:42,118 DISCUSSIONS FROM YESTERDAY. 141 00:04:42,118 --> 00:04:43,753 >> THANK YOU, SUSAN AND IT'S 142 00:04:43,753 --> 00:04:46,022 NICE TO BE HERE WITH EVERYONE. 143 00:04:46,022 --> 00:04:48,124 I'M NITA, A PROFESSOR OF LAW AND 144 00:04:48,124 --> 00:04:50,994 PHILOSOPHY AT DUKE UNIVERSITY 145 00:04:50,994 --> 00:04:53,329 WHERE I HEAD UP THE DUKE 146 00:04:53,329 --> 00:04:53,930 INITIATIVE FOR SCIENCE AND 147 00:04:53,930 --> 00:04:56,833 SOCIETY AND THE CO-CHAIR OF THE 148 00:04:56,833 --> 00:04:58,101 NEUROETHICS WORKING GROUP. 149 00:04:58,101 --> 00:05:00,136 FOR THOSE OF YOU WHO MIGHT BE 150 00:05:00,136 --> 00:05:02,038 NEW TO THE NEUROETHICS WORKING 151 00:05:02,038 --> 00:05:05,341 GROUP OR NEW TODAY, THE BRAIN 152 00:05:05,341 --> 00:05:06,276 NEUROETHICS WORKING GROUP IS A 153 00:05:06,276 --> 00:05:09,045 GROUP OF 10 EXPERTS IN 154 00:05:09,045 --> 00:05:11,814 NEUROETHICS AND NEUROSCIENCE 155 00:05:11,814 --> 00:05:13,917 THAT PROVIDE NEUROETHICS INPUT 156 00:05:13,917 --> 00:05:14,551 TO BRAIN. 157 00:05:14,551 --> 00:05:17,720 IT WAS FORMED IN THE SUMMER OF 158 00:05:17,720 --> 00:05:20,256 2015 AND THE GROUP WHICH IS 159 00:05:20,256 --> 00:05:23,560 CURRENTLY COCHAIRED BY DR. GRADY 160 00:05:23,560 --> 00:05:24,561 AND MYSELF, MEETS TWICE A YEAR 161 00:05:24,561 --> 00:05:25,528 IN JANUARY AND AUGUST. 162 00:05:25,528 --> 00:05:28,865 AND WE HOLD TOPICAL WORKSHOPS 163 00:05:28,865 --> 00:05:29,866 WHEN APPROPRIATE LIKE OUR RECENT 164 00:05:29,866 --> 00:05:32,835 ONE THIS SUMMER FOCUSED ON BRAIN 165 00:05:32,835 --> 00:05:34,571 DATA AND HOW TO THINK SOME OF 166 00:05:34,571 --> 00:05:36,906 THE PRIVACY IMPLICATIONS AS WELL 167 00:05:36,906 --> 00:05:38,541 AS WHAT A POTENTIAL PATHWAY 168 00:05:38,541 --> 00:05:39,542 FORWARD WOULD BE. 169 00:05:39,542 --> 00:05:41,144 THE GROUP IS CHARGED WITH 170 00:05:41,144 --> 00:05:43,846 IDENTIFYING ETHICAL CHALLENGES 171 00:05:43,846 --> 00:05:46,149 IN THE DEVELOPMENT OR 172 00:05:46,149 --> 00:05:48,451 APPLICATION OF BRAIN RESEARCH. 173 00:05:48,451 --> 00:05:50,320 IN ANTICIPATING OR PROVIDING 174 00:05:50,320 --> 00:05:52,755 WAYS FOR BRAIN TO NAVIGATE THOSE 175 00:05:52,755 --> 00:05:54,457 ETHICAL CHALLENGES IN PROVIDING 176 00:05:54,457 --> 00:05:56,626 ETHICS CONSULTATIONS, WHEN 177 00:05:56,626 --> 00:05:56,926 APPROPRIATE. 178 00:05:56,926 --> 00:05:58,761 AND WE HAD PROGRAM OFFICERS 179 00:05:58,761 --> 00:06:00,363 BRING US DIFFERENT ISSUES WE 180 00:06:00,363 --> 00:06:04,233 MIGHT DO CONSULTATIONS ON AND 181 00:06:04,233 --> 00:06:05,735 IDENTIFYING RESEARCH ETHICS 182 00:06:05,735 --> 00:06:06,836 QUESTIONS THAT CAN BE ADDRESSED 183 00:06:06,836 --> 00:06:07,670 THROUGH FUNDING OPPORTUNITIES 184 00:06:07,670 --> 00:06:09,539 AND IN PUBLISHING GUIDANCE ON 185 00:06:09,539 --> 00:06:12,141 KEY ETHICAL CHALLENGES TIED TO 186 00:06:12,141 --> 00:06:13,843 BRAIN RESEARCH. 187 00:06:13,843 --> 00:06:15,778 YESTERDAY'S MEETING I THOUGHT 188 00:06:15,778 --> 00:06:17,680 WAS A TRULY ENRICHING 189 00:06:17,680 --> 00:06:18,014 CONVERSATION. 190 00:06:18,014 --> 00:06:20,450 I DO ENCOURAGE YOU TO LISTEN TO 191 00:06:20,450 --> 00:06:20,750 IT. 192 00:06:20,750 --> 00:06:22,652 AND WE BROKE IT UP INTO TWO 193 00:06:22,652 --> 00:06:24,654 DIFFERENT SESSIONS. 194 00:06:24,654 --> 00:06:26,856 SO, IN THOSE TWO TOPICS, THE 195 00:06:26,856 --> 00:06:29,258 FIRST SESSION WAS FOCUSING ON A 196 00:06:29,258 --> 00:06:32,161 TOPIC WE HAVEN'T REALLY TAKEN ON 197 00:06:32,161 --> 00:06:34,364 UNTIL NOW, WHICH WAS TO LISTEN 198 00:06:34,364 --> 00:06:36,265 TO DIFFERENT PERSPECTIVESES FROM 199 00:06:36,265 --> 00:06:38,901 FOUR CLINICIANS AND ETHICIST 200 00:06:38,901 --> 00:06:41,371 LOOKING TO SEE IF OR DISCUSS 201 00:06:41,371 --> 00:06:43,239 WHETHER THERE WERE UNIQUE, IF 202 00:06:43,239 --> 00:06:46,376 ANY, ETHICAL CONSIDERATIONS TO 203 00:06:46,376 --> 00:06:48,845 CONSIDER AROUND PEDIATRIC 204 00:06:48,845 --> 00:06:49,946 NEUROSTIMULATION STUDIES. 205 00:06:49,946 --> 00:06:53,483 WE ASKED THEM WHETHER THESE 206 00:06:53,483 --> 00:06:54,150 CONSIDERATIONS DIFFERED FROM 207 00:06:54,150 --> 00:06:56,085 GENERAL COMPLEXITIES IN WORKING 208 00:06:56,085 --> 00:06:58,454 WITH PEDIATRIC POPULATIONS THAT 209 00:06:58,454 --> 00:07:00,123 CAN RAISE ISSUES RELATEDDED TO, 210 00:07:00,123 --> 00:07:03,192 FOR EXAMPLE, CONSIDERING THE 211 00:07:03,192 --> 00:07:05,161 RISK BENEFITS APPROACH AND RATIO 212 00:07:05,161 --> 00:07:08,364 FOR CHILDREN VERSES ADULTS, THE 213 00:07:08,364 --> 00:07:10,066 LIMITED MARKET SIZE AND MUCH 214 00:07:10,066 --> 00:07:12,969 HIGHER COST OF PEDIATRIC TRIALS, 215 00:07:12,969 --> 00:07:15,271 CONSENT AND ASCENT FRAMEWORKS, 216 00:07:15,271 --> 00:07:16,873 VULNERABILITY AND SOCIAL 217 00:07:16,873 --> 00:07:18,307 DETERMINANTS OF HEALTH. 218 00:07:18,307 --> 00:07:21,244 ONE OF THE CORE THEMES OF THIS 219 00:07:21,244 --> 00:07:22,478 SESSION WHILE NOT NECESSARILY 220 00:07:22,478 --> 00:07:24,747 UNIQUE TO PEDIATRIC 221 00:07:24,747 --> 00:07:26,082 NEUROSTIMULATION RESEARCH, WAS 222 00:07:26,082 --> 00:07:28,851 THIS IDEA OF PROTECTING CHILDREN 223 00:07:28,851 --> 00:07:29,786 THROUGH RESEARCH RATHER THAN 224 00:07:29,786 --> 00:07:30,586 FROM RESEARCH. 225 00:07:30,586 --> 00:07:32,555 THE IDEA THERE IS THAT A LOT OF 226 00:07:32,555 --> 00:07:34,490 TIMES WHEN PEOPLE THINK ABOUT 227 00:07:34,490 --> 00:07:36,492 ETHICS OR TALK ABOUT ETHICS, 228 00:07:36,492 --> 00:07:38,961 THEY TALK ABOUT IT AS SAFEGUARDS 229 00:07:38,961 --> 00:07:39,796 AGAINST DOING SOMETHING. 230 00:07:39,796 --> 00:07:43,900 HERE THE IDEA IS THAT A KEY WAY 231 00:07:43,900 --> 00:07:46,869 FORWARD IS TO REALLY THINK ABOUT 232 00:07:46,869 --> 00:07:48,971 HOW WE SHOULD BE DESIGNING AND 233 00:07:48,971 --> 00:07:50,573 THINKING ABOUT THE RESEARCH IN 234 00:07:50,573 --> 00:07:52,742 WAYS THAT BOTH ARE MORE 235 00:07:52,742 --> 00:07:54,077 INCLUSIVE OF CHILDREN AND ALSO 236 00:07:54,077 --> 00:07:54,977 CREATE BENEFITS FOR CHILDREN. 237 00:07:54,977 --> 00:07:56,879 SO IT'S PROTECTIVE THROUGH THE 238 00:07:56,879 --> 00:07:59,882 RESEARCH RATHER THAN FROM THE 239 00:07:59,882 --> 00:08:02,318 RESEARCH ITSELF. 240 00:08:02,318 --> 00:08:04,120 SOME OF THE ADDITIONAL TAKEAWAYS 241 00:08:04,120 --> 00:08:05,488 WE HEARD WERE THAT IT'S REALLY 242 00:08:05,488 --> 00:08:08,791 IMPORTANT TO HAVE SOME 243 00:08:08,791 --> 00:08:10,093 THOUGHTFULNESS ABOUT SOME OF THE 244 00:08:10,093 --> 00:08:12,328 KINDS OF KNEE JERK INSTINCTS WE 245 00:08:12,328 --> 00:08:14,297 TEND TO GO FOR IN RESEARCH, LIKE 246 00:08:14,297 --> 00:08:17,166 THE IDEA FOR EXAMPLE, OF DEES 247 00:08:17,166 --> 00:08:18,701 CAERATION FROM ADULTS TO 248 00:08:18,701 --> 00:08:18,968 CHILDREN. 249 00:08:18,968 --> 00:08:20,470 SO THE IDEA OR ASSUMPTION THAT 250 00:08:20,470 --> 00:08:22,605 ADULTS SHOULD BE TESTED BEFORE 251 00:08:22,605 --> 00:08:24,173 OLDER KIDS. 252 00:08:24,173 --> 00:08:27,677 OLDER KIDS TESTED BEFORE YOUNGER 253 00:08:27,677 --> 00:08:28,377 KIDS. 254 00:08:28,377 --> 00:08:29,979 AND THE THOUGHT HERE OR TAKE 255 00:08:29,979 --> 00:08:31,380 AWAY HERE WAS WE REALLY NEED TO 256 00:08:31,380 --> 00:08:32,982 HAVE A JUSTIFICATION FOR DOING 257 00:08:32,982 --> 00:08:33,382 THAT. 258 00:08:33,382 --> 00:08:35,184 IN SOME SITUATIONS THAT MAKES 259 00:08:35,184 --> 00:08:35,384 SENSE. 260 00:08:35,384 --> 00:08:36,986 YOU DON'T KNOW WHAT THE RISKS 261 00:08:36,986 --> 00:08:38,988 ARE UNTIL THE DEESCALATION IS A 262 00:08:38,988 --> 00:08:41,491 IMPORTANT WAY FORWARD, BUT THE 263 00:08:41,491 --> 00:08:43,493 IDEA IS TO RATHER THAN 264 00:08:43,493 --> 00:08:44,594 IMPLEMENTING THAT AS A MATTER OF 265 00:08:44,594 --> 00:08:47,663 COURSE TO REALLY BE MUCH MORE 266 00:08:47,663 --> 00:08:48,998 THOUGHTFUL ABOUT WHEN THAT IS 267 00:08:48,998 --> 00:08:50,299 APPROPRIATE AND IMPLEMENTING IT 268 00:08:50,299 --> 00:08:52,201 ONLY IN THOSE SITUATIONS. 269 00:08:52,201 --> 00:08:54,837 A SECOND WAS THINKING ABOUT 270 00:08:54,837 --> 00:08:56,506 ACCOMMODATIONS FOR THOSE WITH 271 00:08:56,506 --> 00:08:57,507 DIFFICULT SOCIAL CIRCUMSTANCES 272 00:08:57,507 --> 00:09:00,376 TO BE ABLE TO PARTICIPATE IN 273 00:09:00,376 --> 00:09:01,077 PEDIATRIC NEUROSTIMULATION 274 00:09:01,077 --> 00:09:02,311 STUDIESES AND HOW TO IMPLEMENT 275 00:09:02,311 --> 00:09:04,180 IN SETTING UP THE SUPPORT 276 00:09:04,180 --> 00:09:06,716 NETWORKS TO DIVERSE TRIAL 277 00:09:06,716 --> 00:09:07,583 PARTICIPANTS AND ACCESS. 278 00:09:07,583 --> 00:09:09,485 WE HAD ACROSS BOTH PANELS, A LOT 279 00:09:09,485 --> 00:09:11,587 OF CONVERSATIONS AROUND THE IDEA 280 00:09:11,587 --> 00:09:14,290 OF THINKING ABOUT WHAT ARE THE 281 00:09:14,290 --> 00:09:15,224 ANCILLARY OR ADDITIONAL SUPPORTS 282 00:09:15,224 --> 00:09:16,492 WE NEED TO BE THINKING ABOUT 283 00:09:16,492 --> 00:09:18,427 AROUND CLINICAL STUDIES AND 284 00:09:18,427 --> 00:09:18,828 RESEARCH. 285 00:09:18,828 --> 00:09:20,763 AND THE THIRD OF THE COMMUNITY 286 00:09:20,763 --> 00:09:22,799 ENGAGEMENT EARLY AND OFTEN ON 287 00:09:22,799 --> 00:09:24,700 THE DESIGN OF AN INTERVENTION 288 00:09:24,700 --> 00:09:25,134 TRIAL. 289 00:09:25,134 --> 00:09:27,003 YOU HEAR THAT IDEA AND THAT 290 00:09:27,003 --> 00:09:30,106 MANTRA A LOT IN NEUROETHICS OR 291 00:09:30,106 --> 00:09:30,873 BIOETHICAL RESEARCH ABOUT THE 292 00:09:30,873 --> 00:09:32,608 IMPORTANCE OF STAKEHOLDER 293 00:09:32,608 --> 00:09:34,544 ENGAGEMENT AND ABOUT COMMUNITY 294 00:09:34,544 --> 00:09:36,412 ENGAGEMENT BEING A KEY ASPECT OF 295 00:09:36,412 --> 00:09:36,612 IT. 296 00:09:36,612 --> 00:09:38,915 A LOT OF THE ISSUES WE EXPLORED 297 00:09:38,915 --> 00:09:42,118 MAY NOT ULTIMATELY BE UNIQUE TO 298 00:09:42,118 --> 00:09:42,919 PEDIATRIC NEUROSTIMULATION 299 00:09:42,919 --> 00:09:45,021 RESEARCH BUT THE DISCUSSION 300 00:09:45,021 --> 00:09:47,123 RAISED UNRESOLVED ISSUES THAT 301 00:09:47,123 --> 00:09:49,091 MAY WARRANT FURTHER EXPLORATION 302 00:09:49,091 --> 00:09:50,693 AND WE'LL CONTINUE TO HAVE 303 00:09:50,693 --> 00:09:52,195 FOLLOW-UP CONVERSATIONS TO SEE 304 00:09:52,195 --> 00:09:55,331 WHETHER IT MAKE SENSE TO EXPLORE 305 00:09:55,331 --> 00:09:56,933 THIS AROUND PEDIATRIC 306 00:09:56,933 --> 00:09:58,100 NEUROSTIMULATION OR AS A USE 307 00:09:58,100 --> 00:09:59,902 CASE TO HELPS US UNDERSTAND THE 308 00:09:59,902 --> 00:10:03,606 UNRESOLVED ISSUES MORE BROADLY. 309 00:10:03,606 --> 00:10:05,641 OUR SECOND SESSION WAS AN 310 00:10:05,641 --> 00:10:07,844 INVITATION TO LEADING 311 00:10:07,844 --> 00:10:10,012 RESEARCHERS AND ACADEMICS TO 312 00:10:10,012 --> 00:10:12,215 GIVE US A FORWARD-LOOKING SCAN 313 00:10:12,215 --> 00:10:16,118 OF THE HORIZON ON EMERGING 314 00:10:16,118 --> 00:10:18,321 NEUROETHICS RESEARCH 315 00:10:18,321 --> 00:10:18,821 OPPORTUNITIES. 316 00:10:18,821 --> 00:10:20,523 AND THIS WAS INFORMED BY THE 317 00:10:20,523 --> 00:10:23,292 PERSPECTIVE OF BOTH EARLY STAGE 318 00:10:23,292 --> 00:10:24,427 AS WELL AS ESTABLISHED 319 00:10:24,427 --> 00:10:26,229 INVESTIGATORS IN THE FIELD 320 00:10:26,229 --> 00:10:28,431 GIVING US, PEOPLE WHO HAVE SEEN 321 00:10:28,431 --> 00:10:30,433 ALL OF THE ISSUES OVER A COUPLE 322 00:10:30,433 --> 00:10:32,535 OF DECADES, TO THOSE WHO WERE ON 323 00:10:32,535 --> 00:10:34,337 THE CUTTING-EDGE OF NEW TOPICS 324 00:10:34,337 --> 00:10:36,239 THEY ARE BRINGING INTO THE 325 00:10:36,239 --> 00:10:36,639 FIELD. 326 00:10:36,639 --> 00:10:38,608 AMONG THE TOPICS THAT WE 327 00:10:38,608 --> 00:10:40,343 EXPLORED, WE HEARD FIRST FROM 328 00:10:40,343 --> 00:10:42,445 DR. JOE FINNS ABOUT THE 329 00:10:42,445 --> 00:10:45,047 IMPORTANCE AND VALUE OF PERSONAL 330 00:10:45,047 --> 00:10:45,314 IDENTITY. 331 00:10:45,314 --> 00:10:47,250 AND THE EXTENT TO WHICH 332 00:10:47,250 --> 00:10:47,817 INTERVENTIONS, WHEN THROUGH 333 00:10:47,817 --> 00:10:50,152 DRUGS OR DEVICES, CAN SHIFT THAT 334 00:10:50,152 --> 00:10:53,856 SENSE OF IDENTITY OR CAN CREATE 335 00:10:53,856 --> 00:10:54,957 RESTORATION OF SELF 336 00:10:54,957 --> 00:10:56,359 DETERMINATION AND SELF IDENTITY, 337 00:10:56,359 --> 00:10:57,994 WHICH RAISES SOME INTERESTING 338 00:10:57,994 --> 00:10:59,262 ETHICAL QUESTIONS. 339 00:10:59,262 --> 00:11:01,664 AGAIN POTENTIALLY NOT UNIQUE 340 00:11:01,664 --> 00:11:04,967 JUST TO IMPLANTED 341 00:11:04,967 --> 00:11:06,269 NEUROTECHNOLOGY, A DEEP BRAIN 342 00:11:06,269 --> 00:11:06,869 STIMULATION. 343 00:11:06,869 --> 00:11:08,571 IT MAY BE TRUE ACROSS LOTS OF 344 00:11:08,571 --> 00:11:11,540 DIFFERENT CATEGORIES OF LIFE 345 00:11:11,540 --> 00:11:12,241 CHANGING EVENTS. 346 00:11:12,241 --> 00:11:14,277 BUT IT'S AN IMPORTANT AREA FOR 347 00:11:14,277 --> 00:11:15,878 CONTINUED CONVERSATION, 348 00:11:15,878 --> 00:11:18,214 ESPECIALLY AS IT COMES TO AREAS 349 00:11:18,214 --> 00:11:18,748 OF NEUROTECHNOLOGY. 350 00:11:18,748 --> 00:11:22,652 SECOND WE HEARD FROM DR. ALEX 351 00:11:22,652 --> 00:11:24,153 YOUTH AND THIS IS WORTH TUNING 352 00:11:24,153 --> 00:11:27,957 IN JUST TO HEAR HIS LATEST 353 00:11:27,957 --> 00:11:28,357 RESEARCH. 354 00:11:28,357 --> 00:11:29,558 THIS SESSION YESTERDAY I THINK 355 00:11:29,558 --> 00:11:31,360 IT SURPRISED A NUMBER OF US HOW 356 00:11:31,360 --> 00:11:33,729 RAPIDLY THE FIELD IS EVOLVING 357 00:11:33,729 --> 00:11:35,364 AND THE WORK HE IS DOING. 358 00:11:35,364 --> 00:11:38,301 WE LEARNED ABOUT HOW FMRI 359 00:11:38,301 --> 00:11:39,568 DECODING TECHNOLOGY IS SHIFTING. 360 00:11:39,568 --> 00:11:41,671 WHAT WE CAN AND CAN'T 361 00:11:41,671 --> 00:11:43,873 EXTRAPOLATE FROM FMRI DATA ABOUT 362 00:11:43,873 --> 00:11:47,543 WHAT A PERSON IS THINKING OR 363 00:11:47,543 --> 00:11:48,978 MANAGING OR EVEN WHAT'S 364 00:11:48,978 --> 00:11:52,048 HAPPENING DURING RESTING STATES. 365 00:11:52,048 --> 00:11:55,584 AND IT'S REALLY ASTONISHING THE 366 00:11:55,584 --> 00:11:58,254 PACE AT WHICH THE DATA HE WAS 367 00:11:58,254 --> 00:12:00,890 PRESENTING IS BEING FUELED BY 368 00:12:00,890 --> 00:12:01,991 CHANGES IN GENERATIVE AI. 369 00:12:01,991 --> 00:12:04,360 THEY HAD OUT OF HIS LAB AN 370 00:12:04,360 --> 00:12:05,061 IMPORTANT RESEARCH PAPER THAT 371 00:12:05,061 --> 00:12:08,364 CAME OUT IN APRIL THAT INCLUDED 372 00:12:08,364 --> 00:12:10,166 A FIRST-OF-ITS-KIND SET OF 373 00:12:10,166 --> 00:12:12,768 EXPERIMENTS TRYING TO ADDRESS 374 00:12:12,768 --> 00:12:15,871 ETHICAL CONCERNS THAT FMRI 375 00:12:15,871 --> 00:12:17,473 DECODING COULD PRESENT WITH SOME 376 00:12:17,473 --> 00:12:20,276 PERSPECTIVE AT THAT TIME ABOUT 377 00:12:20,276 --> 00:12:21,243 ASSURANCES, ABOUT SAFEGUARDS 378 00:12:21,243 --> 00:12:23,346 THAT EXISTED BY LIMITATIONS IN 379 00:12:23,346 --> 00:12:24,680 THE TECHNOLOGY ITSELF, WHICH 380 00:12:24,680 --> 00:12:25,781 BASED ON THEIR CURRENT RESEARCH 381 00:12:25,781 --> 00:12:27,984 IS NO LONGER A LIMITATION, 382 00:12:27,984 --> 00:12:30,186 SHOWING AGAIN HOW QUICKLY THIS 383 00:12:30,186 --> 00:12:32,521 IS SHIFTING AND CHANGING. 384 00:12:32,521 --> 00:12:34,256 DR. TRYST IN MACINTOSH TOLD US 385 00:12:34,256 --> 00:12:36,258 ABOUT AN ONGOING BRAIN GRANT 386 00:12:36,258 --> 00:12:38,060 EXPLORING THE FACTORS THAT 387 00:12:38,060 --> 00:12:39,929 SHAPES DECISIONS AND INDUSTRY 388 00:12:39,929 --> 00:12:41,664 SECTORS THAT CONDUCT 389 00:12:41,664 --> 00:12:43,666 NEUROTECHNOLOGY, RESEARCH AND 390 00:12:43,666 --> 00:12:44,066 COMMERCIALIZATION. 391 00:12:44,066 --> 00:12:45,968 SO, I WOULD WELCOME ANY 392 00:12:45,968 --> 00:12:46,736 QUESTIONS OR THOUGHTS. 393 00:12:46,736 --> 00:12:48,637 BUT THAT GIVES YOU A GOOD SENSE, 394 00:12:48,637 --> 00:12:50,873 I HOPE, OF THE CONVERSATIONS WE 395 00:12:50,873 --> 00:12:59,815 HAD YESTERDAY. 396 00:12:59,815 --> 00:13:00,583 >> THANK YOU. 397 00:13:00,583 --> 00:13:03,552 ANY QUESTIONS, COMMENTS? 398 00:13:03,552 --> 00:13:05,888 PLEASE USE THE HAND RAISE 399 00:13:05,888 --> 00:13:12,495 FUNCTION IF YOU WOULD LIKE TO -- 400 00:13:12,495 --> 00:13:12,962 JOHN? 401 00:13:12,962 --> 00:13:15,765 >> YES, JUST ECHOING NITA'S 402 00:13:15,765 --> 00:13:16,065 COMMENTS. 403 00:13:16,065 --> 00:13:17,800 THANK YOU IF ARE THAT TERRIFIC 404 00:13:17,800 --> 00:13:18,167 SUMMARY. 405 00:13:18,167 --> 00:13:20,269 IT REALLY WAS A VERY RICH SET OF 406 00:13:20,269 --> 00:13:20,569 DISCUSSIONS. 407 00:13:20,569 --> 00:13:23,773 AND IT REALLY WAS QUITE AMAZING 408 00:13:23,773 --> 00:13:26,175 TO SEE HOW RAPIDLY SOME OF THESE 409 00:13:26,175 --> 00:13:29,178 FIELDS PROGRESSED WHEN AN ALEX, 410 00:13:29,178 --> 00:13:31,080 FOR EXAMPLE, PUBLISHED HIS PAPER 411 00:13:31,080 --> 00:13:36,285 ON USING FMRI TO INFER SA MANTIC 412 00:13:36,285 --> 00:13:38,788 MEANING IN SENTENCES THAT WE 413 00:13:38,788 --> 00:13:40,756 THOUGHT IT WILL BE YEARS BEFORE 414 00:13:40,756 --> 00:13:42,091 THEY CAN HAVE THESE ALGORITHMS 415 00:13:42,091 --> 00:13:45,227 TO DO BETTER ON LESS DATA. 416 00:13:45,227 --> 00:13:47,696 AND GEEZ, IT'S LIKE IT REALLY 417 00:13:47,696 --> 00:13:49,298 NEEDS TO GET AHEAD OF THESE 418 00:13:49,298 --> 00:13:50,299 ISSUES BECAUSE THEY WILL OVER 419 00:13:50,299 --> 00:13:52,401 TAKE US IF WE ARE NOT PAYING 420 00:13:52,401 --> 00:13:52,701 ATTENTION. 421 00:13:52,701 --> 00:13:55,404 >> I DIDN'T EXPECT THE RESULTS 422 00:13:55,404 --> 00:13:57,106 THAT HE WAS PRESENTING IN 423 00:13:57,106 --> 00:13:58,107 PRELIMINARY RESULTS THEY HAD 424 00:13:58,107 --> 00:13:59,175 FROM YESTERDAY. 425 00:13:59,175 --> 00:14:01,077 SO JUST TO TANTALIZE YOU ALL 426 00:14:01,077 --> 00:14:03,412 MORE TO TUNE IN AND LISTEN IN. 427 00:14:03,412 --> 00:14:04,413 >> IT'S QUITE REMARKABLE AND 428 00:14:04,413 --> 00:14:05,448 REALLY EXCITING. 429 00:14:05,448 --> 00:14:08,184 WE DO NEED TO MAKE SURE WE GET 430 00:14:08,184 --> 00:14:14,490 AHEAD OF THIS BEAST. 431 00:14:14,490 --> 00:14:14,790 >> AGREED. 432 00:14:14,790 --> 00:14:18,861 >> THANK YOU, EVERYONE. 433 00:14:18,861 --> 00:14:23,299 >> THANK YOU, NITA. 434 00:14:23,299 --> 00:14:25,401 >> AM I UP NEXT. 435 00:14:25,401 --> 00:14:25,801 >> YOU ARE. 436 00:14:25,801 --> 00:14:27,403 >> I'D LIKE TO ADD TO SUSAN'S 437 00:14:27,403 --> 00:14:29,004 WELCOME TO EVERYBODY HERE. 438 00:14:29,004 --> 00:14:30,306 AND THANK YOU FOR MAKING THE 439 00:14:30,306 --> 00:14:32,208 TIME AND FOR THE WORK YOU DO ON 440 00:14:32,208 --> 00:14:33,342 OUR BEHALF AND THE STAFF WHO 441 00:14:33,342 --> 00:14:34,877 MADE THIS MEETING POSSIBLE, ALL 442 00:14:34,877 --> 00:14:37,913 THE WORK THAT WENT INTO IT. 443 00:14:37,913 --> 00:14:41,984 ESPECIALLY KRISTIN, DEB AND 444 00:14:41,984 --> 00:14:43,519 MICHELLE. 445 00:14:43,519 --> 00:14:44,220 SO LET'S SEE. 446 00:14:44,220 --> 00:14:46,522 I HAVE SOME UPDATES HERE. 447 00:14:46,522 --> 00:14:47,723 I'LL TRY TO BE EFFICIENT. 448 00:14:47,723 --> 00:14:51,894 A LOT TO COVER. 449 00:14:51,894 --> 00:14:53,596 HOW THAT LOOK TO EVERYBODY? 450 00:14:53,596 --> 00:14:55,131 DOES THAT LOOK REASONABLE? 451 00:14:55,131 --> 00:14:55,464 >> YES. 452 00:14:55,464 --> 00:14:57,500 >> LET ME MOVE MY MENU BARS. 453 00:14:57,500 --> 00:14:59,702 THEY ARE ALWAYS IN THE WAY. 454 00:14:59,702 --> 00:15:01,804 GREAT, SO AGAIN WELCOME 455 00:15:01,804 --> 00:15:03,706 EVERYBODY TO THIS FEBRUARY 2024 456 00:15:03,706 --> 00:15:07,009 MEETING OF MULTI-COUNCIL WORKING 457 00:15:07,009 --> 00:15:07,710 GROUP. 458 00:15:07,710 --> 00:15:09,111 AS SUSAN MENTIONED, WE HAVE A 459 00:15:09,111 --> 00:15:12,214 FEW MEMBERS ROTATING OFF. 460 00:15:12,214 --> 00:15:13,516 DAN WAS THE REPRESENTATIVE FROM 461 00:15:13,516 --> 00:15:16,118 THE NIDCD, THANK YOU, DAMAGE, 462 00:15:16,118 --> 00:15:17,419 WHEREVER YOU ARE FOR ALL THE 463 00:15:17,419 --> 00:15:19,722 GREAT IN SITU GAVE TO US. 464 00:15:19,722 --> 00:15:24,026 AMY BERNARD FROM THE FOUNDATION 465 00:15:24,026 --> 00:15:25,728 THAT SERVED AS OUR 466 00:15:25,728 --> 00:15:26,595 REPRESENTATIVE FROM THE BRAIN 467 00:15:26,595 --> 00:15:29,198 INITIATIVE ALLIANCE, WHICH IS 468 00:15:29,198 --> 00:15:31,233 THIS COLLECTION OF GOVERNMENT 469 00:15:31,233 --> 00:15:32,902 FEDERAL AND NON FEDERAL PARTNERS 470 00:15:32,902 --> 00:15:36,105 WHO HAVE BEEN PUSHING THE BRAIN 471 00:15:36,105 --> 00:15:37,106 INITIATIVE. 472 00:15:37,106 --> 00:15:38,274 THE BRAIN INITIATIVE ALLIANCE 473 00:15:38,274 --> 00:15:40,809 HAS TWO CO-CHAIRS, THE FEDERAL 474 00:15:40,809 --> 00:15:42,211 CO-CHAIR AND NON FEDERAL 475 00:15:42,211 --> 00:15:42,478 CO-CHAIR. 476 00:15:42,478 --> 00:15:44,613 I CONTINUE TO BE THE FEDERAL 477 00:15:44,613 --> 00:15:45,814 CO-CHAIR. 478 00:15:45,814 --> 00:15:46,715 AMY WAS GLACIAL ENOUGH TO TAKE 479 00:15:46,715 --> 00:15:48,117 ON THAT ROLE FROM THE 480 00:15:48,117 --> 00:15:52,221 NON-FEDERAL SIDE AND ABLY SERVED 481 00:15:52,221 --> 00:15:53,989 IN THAT ROLE AS WELL AS A 482 00:15:53,989 --> 00:15:55,057 REPRESENTATIVE TO THE MCWG AND 483 00:15:55,057 --> 00:15:57,026 IT WAS A PLEASURE WORKING WITH 484 00:15:57,026 --> 00:15:59,828 HER ON THAT. 485 00:15:59,828 --> 00:16:02,231 AND THEN DR. SARMA, A PROGRAM 486 00:16:02,231 --> 00:16:04,300 OFFICER REPRESENTING DARPA TO 487 00:16:04,300 --> 00:16:05,601 ADVANCE RESEARCH PROJECTS 488 00:16:05,601 --> 00:16:05,834 AGENCY. 489 00:16:05,834 --> 00:16:06,936 THANK YOU FOR YOUR SERVICE 490 00:16:06,936 --> 00:16:09,205 WHEREVER YOU MAY BE. 491 00:16:09,205 --> 00:16:10,973 WE WELCOME DAN MERFELD WHO 492 00:16:10,973 --> 00:16:13,909 REPRESENTS NIDCD AS THE IC REP. 493 00:16:13,909 --> 00:16:17,112 HE IS IN THE DEPARTMENT OF HEAD 494 00:16:17,112 --> 00:16:20,316 AND NECK SURGERY AT OHIO STATE 495 00:16:20,316 --> 00:16:22,751 IN VESTIBULAR SYSTEMS AND 496 00:16:22,751 --> 00:16:24,520 COMPUTATIONAL NEUROSCIENCE. 497 00:16:24,520 --> 00:16:26,422 HE HAS DONE VERY INTERESTING 498 00:16:26,422 --> 00:16:28,123 WORK AND PLEASED TO HAVE HIM 499 00:16:28,123 --> 00:16:30,125 HERE TO REPRESENT THE INTERESTS 500 00:16:30,125 --> 00:16:32,228 OF NIDCD. 501 00:16:32,228 --> 00:16:37,833 AND THEN WE PLACING AMY BERNARD 502 00:16:37,833 --> 00:16:39,201 AS THE CO-CHAIR OF THE BIA 503 00:16:39,201 --> 00:16:42,938 THROUGH ELECTION OF THE GROUP, 504 00:16:42,938 --> 00:16:45,007 IS ALYSSA SCHAFFER. 505 00:16:45,007 --> 00:16:46,342 THE SIMONS FOUNDATION HAS BEEN 506 00:16:46,342 --> 00:16:48,444 SUPPORTING ALL KINDS OF AMAZING 507 00:16:48,444 --> 00:16:49,745 NEUROSCIENCE ACROSS MULTIPLE 508 00:16:49,745 --> 00:16:50,913 DOMAINS, ESPECIALLY IN THE 509 00:16:50,913 --> 00:16:53,015 AUTISM RESEARCH DOMAIN AND STOOD 510 00:16:53,015 --> 00:16:54,650 UP A NUMBER OF REALLY GREAT 511 00:16:54,650 --> 00:16:56,385 PROGRAMS, INCLUDING FOR 512 00:16:56,385 --> 00:16:57,653 EARLY-STAGE INVESTIGATORS AND 513 00:16:57,653 --> 00:17:01,123 ALYSSA COMES TO US AS THEIR 514 00:17:01,123 --> 00:17:02,324 VICE PRESIDENT AND SENIOR 515 00:17:02,324 --> 00:17:03,225 SCIENTIST IN NEUROSCIENCE 516 00:17:03,225 --> 00:17:04,226 COLLABORATIONS AT THE FOUNDATION 517 00:17:04,226 --> 00:17:05,327 AND WE'LL HEAR FROM HER ABOUT 518 00:17:05,327 --> 00:17:07,229 THE WORK THEY ARE DOING AND HOW 519 00:17:07,229 --> 00:17:09,732 THEY ARE HELPING TO PUSH THE 520 00:17:09,732 --> 00:17:11,533 FIELD FORWARD IN CONCERT WITH 521 00:17:11,533 --> 00:17:13,202 WHAT WE ARE DOING HERE AT THE 522 00:17:13,202 --> 00:17:15,037 BRAIN INITIATIVE AT NIH. 523 00:17:15,037 --> 00:17:18,173 THEN I'D LIKE TO WELCOME 524 00:17:18,173 --> 00:17:19,642 LIEUTENANT COLONEL ADAM WILLIS 525 00:17:19,642 --> 00:17:20,242 FROM DARPA. 526 00:17:20,242 --> 00:17:22,244 A PROGRAM MANAGER IN THE 527 00:17:22,244 --> 00:17:25,014 BIOLOGICAL TECHNOLOGIES OFFICE 528 00:17:25,014 --> 00:17:25,914 AT DARPA. 529 00:17:25,914 --> 00:17:27,316 HIS SPECIFIC RESEARCH INTERESTS 530 00:17:27,316 --> 00:17:29,318 ARE IN BRAIN MECHANICS BRAIN 531 00:17:29,318 --> 00:17:31,453 INJURY, HE IS A CRITICAL CARE 532 00:17:31,453 --> 00:17:33,589 PHYSICIAN AND HE IS AN ASSOCIATE 533 00:17:33,589 --> 00:17:36,625 PROFESSOR OF NEUROLOGY AT THE 534 00:17:36,625 --> 00:17:37,926 UNIFORM SERVICES UNIVERSITY AS 535 00:17:37,926 --> 00:17:40,529 WELL AS ADJUNCT ASSISTANT 536 00:17:40,529 --> 00:17:41,630 PROFESSOR AT MICHIGAN STATE. 537 00:17:41,630 --> 00:17:43,232 WE LOOK FORWARD TO ALL THE 538 00:17:43,232 --> 00:17:45,000 PERSPECTIVES YOU CAN GIVE TO US, 539 00:17:45,000 --> 00:17:47,069 BOTH AS A PHYSICIAN AND 540 00:17:47,069 --> 00:17:48,237 INTENSIVIST BUT ALSO 541 00:17:48,237 --> 00:17:50,172 REPRESENTING DARPA, ONE OF OUR 542 00:17:50,172 --> 00:17:51,440 VERY VALUED PARTNERS. 543 00:17:51,440 --> 00:17:53,275 WE HAVE HAD TWO RECENT ADDITIONS 544 00:17:53,275 --> 00:17:56,345 TO THE OFFICE OF BRAIN DIRECTOR, 545 00:17:56,345 --> 00:17:58,647 GINA SAMPSON COMES TO US AFTER 546 00:17:58,647 --> 00:18:02,551 ABOUT 20 PLUS YEARS OF FEDERAL 547 00:18:02,551 --> 00:18:04,386 SERVICE IN THE FORESTRY AND SHE 548 00:18:04,386 --> 00:18:06,055 WILL TAKE ON COMMUNICATION 549 00:18:06,055 --> 00:18:08,557 OUTREACH AND TAKING THE LEAD ON 550 00:18:08,557 --> 00:18:10,259 ORGANIZING OUR ANNUAL BRAIN 551 00:18:10,259 --> 00:18:11,160 INITIATIVE CONFERENCE. 552 00:18:11,160 --> 00:18:13,562 AND I'M SURE YOU WILL AND CAN 553 00:18:13,562 --> 00:18:15,431 LOOK FORWARD TO A TERRIFIC 554 00:18:15,431 --> 00:18:17,633 CONFERENCE COMING UP LATER IN 555 00:18:17,633 --> 00:18:17,833 JUNE. 556 00:18:17,833 --> 00:18:20,135 ALSO I'D LIKE TO WELCOME ALICE 557 00:18:20,135 --> 00:18:22,404 CLAYTON WHO COMES TO US WHO 558 00:18:22,404 --> 00:18:25,341 JOINS US AS A SENIOR ADVISOR IN 559 00:18:25,341 --> 00:18:26,842 THE OFFICE OF THE BRAIN 560 00:18:26,842 --> 00:18:27,109 DIRECTOR. 561 00:18:27,109 --> 00:18:29,078 SHE HAS OVER 14 YEARS OF 562 00:18:29,078 --> 00:18:31,246 EXPERIENCE IN RESEARCH FUNDING 563 00:18:31,246 --> 00:18:31,780 ECOSYSTEM. 564 00:18:31,780 --> 00:18:33,949 SHE SPENT OVER 11 YEARS AT THE 565 00:18:33,949 --> 00:18:35,250 SIMONS FOUNDATION WHERE SHE 566 00:18:35,250 --> 00:18:37,052 STOOD UP SOME REALLY GREAT 567 00:18:37,052 --> 00:18:38,787 PROGRAMS THERE. 568 00:18:38,787 --> 00:18:42,091 FOLLOWED BY ABOUT A YEAR PLUS AT 569 00:18:42,091 --> 00:18:43,359 THE SERGEI BRENT FAMILY 570 00:18:43,359 --> 00:18:45,260 FOUNDATION WHERE SHE SPEARHEADED 571 00:18:45,260 --> 00:18:47,162 THE FRAMEWORK FOR NEW RESEARCH 572 00:18:47,162 --> 00:18:48,731 INITIATIVE IN NEURODEVELOPMENTAL 573 00:18:48,731 --> 00:18:49,732 CONDITIONS. 574 00:18:49,732 --> 00:18:51,667 SHE ACTUALLY COMES BACK TO THE 575 00:18:51,667 --> 00:18:53,369 NIH FAMILY HAVING PREVIOUSLY 576 00:18:53,369 --> 00:18:58,674 BEEN HERE AS A AAA S FELLOW AT 577 00:18:58,674 --> 00:18:58,874 AIMH. 578 00:18:58,874 --> 00:19:00,976 WELCOME TO YOU BOTH AND I'M SURE 579 00:19:00,976 --> 00:19:02,378 YOU WILL SEE MORE FROM THEM IN 580 00:19:02,378 --> 00:19:03,445 THE TIME TO COME. 581 00:19:03,445 --> 00:19:06,348 THE BRAIN INITIATIVE IS 582 00:19:06,348 --> 00:19:08,917 ORGANIZED THROUGH THE WORK OF 583 00:19:08,917 --> 00:19:10,552 NINE PROJECT TEAMS LISTED HERE 584 00:19:10,552 --> 00:19:13,756 COVERING THE DIFFERENT AREAS. 585 00:19:13,756 --> 00:19:14,423 JUST A SMALL ASTERISK NEXT TO A 586 00:19:14,423 --> 00:19:17,659 BIG NAME, DR. J CHURCHILL WHICH 587 00:19:17,659 --> 00:19:19,862 MANY MAY KNOW AS A CO-LEAD IN 588 00:19:19,862 --> 00:19:21,363 TRAINING INCLUSION AND EQUITY 589 00:19:21,363 --> 00:19:21,597 PROGRAM. 590 00:19:21,597 --> 00:19:23,365 HE WILL BE ROTATING OFF TO TAKE 591 00:19:23,365 --> 00:19:24,466 ON OTHER CHALLENGES. 592 00:19:24,466 --> 00:19:25,834 HE WILL STILL BE INVOLVED IN THE 593 00:19:25,834 --> 00:19:27,369 BRAIN INITIATIVE AND IN 594 00:19:27,369 --> 00:19:29,004 TRAINING, BUT STEPPING ASIDE AND 595 00:19:29,004 --> 00:19:33,175 WILL BE ANNOUNCING A NEW PROGRAM 596 00:19:33,175 --> 00:19:34,176 CO-LEAD SHORTLY. 597 00:19:34,176 --> 00:19:36,178 AND IT TAKES NOT JUST A VILLAGE 598 00:19:36,178 --> 00:19:39,581 BUT A CITY OVER 100 PLUS FOLKS 599 00:19:39,581 --> 00:19:41,683 FROM ACROSS THE 10 BRAIN ICs. 600 00:19:41,683 --> 00:19:43,285 WE CANNOT THANK YOU ALL ENOUGH. 601 00:19:43,285 --> 00:19:44,753 I'M SURE BEFORE I GET OFF THIS 602 00:19:44,753 --> 00:19:45,988 CALL, SOMEBODY WILL SAY, YOU 603 00:19:45,988 --> 00:19:48,257 MISSED MY NAME AND FOR THAT, I 604 00:19:48,257 --> 00:19:49,658 APOLOGIZE BUT IT REALLY HAS BEEN 605 00:19:49,658 --> 00:19:51,760 A TREMENDOUS EFFORT FROM MANY, 606 00:19:51,760 --> 00:19:52,661 MANY PEOPLE ACROSS NIH. 607 00:19:52,661 --> 00:19:56,064 SO JUST A QUICK NOTE ABOUT THE 608 00:19:56,064 --> 00:19:56,298 BUDGET. 609 00:19:56,298 --> 00:19:59,067 BRAIN HAS ENJOYED REALLY ROBUST 610 00:19:59,067 --> 00:20:00,769 FUNDING THANKS TO OUR MEMBERS OF 611 00:20:00,769 --> 00:20:02,571 CONGRESS THAT STARTED IN 2014 612 00:20:02,571 --> 00:20:04,973 WITH A 46 MILLION DOLLAR 613 00:20:04,973 --> 00:20:07,309 INVESTMENT TO NIH AND GROWN 614 00:20:07,309 --> 00:20:07,576 STEADILY. 615 00:20:07,576 --> 00:20:08,977 FISCAL YEAR 2023 LAST YEAR, WE 616 00:20:08,977 --> 00:20:12,281 HAD A BUDGET OF 680 MILLION 617 00:20:12,281 --> 00:20:12,781 DOLLARS. 618 00:20:12,781 --> 00:20:15,384 OUR FUNDING COMES IN TWO 619 00:20:15,384 --> 00:20:17,886 SOURCES, THE BASE FUNDING, THE 620 00:20:17,886 --> 00:20:19,788 APPROPRIATIONS MADE TO THE 621 00:20:19,788 --> 00:20:21,890 FUNDING TO OUR 10 PARTICIPATING 622 00:20:21,890 --> 00:20:23,492 BRAIN INSTITUTES AND CENTERS. 623 00:20:23,492 --> 00:20:26,361 AND THEN THE 21ST CENTURY CURES 624 00:20:26,361 --> 00:20:28,764 ACT PROVIDE MONEY ON THAT THAT 625 00:20:28,764 --> 00:20:30,799 HELPED FUEL THIS REMARKABLE 626 00:20:30,799 --> 00:20:33,001 15-FOLD INCREASE IN OUR FUNDING 627 00:20:33,001 --> 00:20:33,235 LEVELS. 628 00:20:33,235 --> 00:20:36,004 AS ALL OF YOU SHOULD BE AWARE, 629 00:20:36,004 --> 00:20:38,373 WE ARE UNDER A CONTINUING 630 00:20:38,373 --> 00:20:39,908 RESOLUTION WHICH HOPEFULLY WILL 631 00:20:39,908 --> 00:20:42,411 BE RESOLVED WITH A PERMANENT 632 00:20:42,411 --> 00:20:45,881 BUDGET COMING MARCH 8 AND WE ARE 633 00:20:45,881 --> 00:20:48,283 JUST WAITING GUARDEDLY 634 00:20:48,283 --> 00:20:49,785 OPTIMISTICALLY ABOUT WHERE OUR 635 00:20:49,785 --> 00:20:52,387 BUDGET WILL LAND FOR FY24. 636 00:20:52,387 --> 00:20:54,389 SO WE WILL LET YOU KNOW AS SOON 637 00:20:54,389 --> 00:20:55,891 AS IT HAPPENS. 638 00:20:55,891 --> 00:20:57,793 SUFFICE IT TO SAY BECAUSE OF THE 639 00:20:57,793 --> 00:20:59,862 REMARKABLE ADVANCES AND 640 00:20:59,862 --> 00:21:02,097 DISCOVERIES MADE BY OUR FUNDED 641 00:21:02,097 --> 00:21:03,499 INVESTIGATORS, WE ARE HOPEFUL 642 00:21:03,499 --> 00:21:05,501 THAT CONGRESS WILL CONTINUE TO 643 00:21:05,501 --> 00:21:07,269 GIVE US ROBUST SUPPORT WE 644 00:21:07,269 --> 00:21:08,303 ENJOYED OVER THE YEARS. 645 00:21:08,303 --> 00:21:10,405 SO A COUPLE OF UPDATES ABOUT 646 00:21:10,405 --> 00:21:12,608 FOLKS IN OUR COMMUNITY. 647 00:21:12,608 --> 00:21:13,976 THERE WAS A RECENT ELECTION OF 648 00:21:13,976 --> 00:21:15,844 NEW MEMBERS SO NATIONAL ACADEMY 649 00:21:15,844 --> 00:21:16,478 OF MEDICINE. 650 00:21:16,478 --> 00:21:20,182 WE ARE VERY PLEASED AND PROUD 651 00:21:20,182 --> 00:21:22,885 THAT FIVE MEMBERS ARE IN VARIOUS 652 00:21:22,885 --> 00:21:24,319 WAYS SHAPES OR FORMS ASSOCIATED 653 00:21:24,319 --> 00:21:28,624 WITH THE BRAIN INITIATIVE. 654 00:21:28,624 --> 00:21:29,525 DR. RASHEED BRASHEAR WAS 655 00:21:29,525 --> 00:21:32,394 RECOGNIZED FOR HIS CONTRIBUTIONS 656 00:21:32,394 --> 00:21:35,597 FOR BIOSENSORS AND DIAGNOSTICS. 657 00:21:35,597 --> 00:21:38,100 DR. MIKE CHANG, DIRECTOR OF THE 658 00:21:38,100 --> 00:21:38,901 NATIONAL EYE INSTITUTE, IS 659 00:21:38,901 --> 00:21:41,103 RECOGNIZED FOR HIS PIONEERING 660 00:21:41,103 --> 00:21:45,974 APPLICATIONS OF INFORMATICS TO 661 00:21:45,974 --> 00:21:48,010 OPTHA MOLOGIY AND ARTIFICIAL 662 00:21:48,010 --> 00:21:48,477 INTELLIGENCE. 663 00:21:48,477 --> 00:21:50,979 DR. PHENGITE BROAD INSTITUTE WAS 664 00:21:50,979 --> 00:21:53,015 RECOGNIZED FOR HIS WORK IN 665 00:21:53,015 --> 00:21:56,184 DEVELOPING GENETIC MODELS FOR 666 00:21:56,184 --> 00:21:59,555 NEURODEVELOPMENTAL DISORDERS. 667 00:21:59,555 --> 00:22:00,088 DR. ZENNING NAME PROBABLY 668 00:22:00,088 --> 00:22:01,790 FAMILIAR TO ALL OF YOU HERE, HAS 669 00:22:01,790 --> 00:22:04,192 BEEN A PIONEER IN LEADING THE 670 00:22:04,192 --> 00:22:05,694 EFFORTS TO THE DEVELOP LARGE 671 00:22:05,694 --> 00:22:07,095 SCALE MAPS OF BRAIN CELL TYPES 672 00:22:07,095 --> 00:22:09,097 AND CONNECTIONS AND SHE IS AT 673 00:22:09,097 --> 00:22:10,499 THE ALLEN INSTITUTE. 674 00:22:10,499 --> 00:22:14,202 AND DR. ZHANG RECOGNIZED FOR 675 00:22:14,202 --> 00:22:17,105 CONTRIBUTIONS TO UNDERSTANDING 676 00:22:17,105 --> 00:22:18,774 EPIGENETICS AND THE MODEL 677 00:22:18,774 --> 00:22:19,207 ENZYMES. 678 00:22:19,207 --> 00:22:20,876 CONGRATULATIONS TO ALL OF YOU. 679 00:22:20,876 --> 00:22:24,713 AND JUST THE OTHER DAY, 680 00:22:24,713 --> 00:22:27,182 DR. BRUCE TROMBERG, DIRECTOR OF 681 00:22:27,182 --> 00:22:29,518 NIBIB, WAS RECOGNIZED BY HIS 682 00:22:29,518 --> 00:22:30,419 INDUCTION INTO THE NATIONAL 683 00:22:30,419 --> 00:22:32,020 ACADEMY OF ENGINEERING. 684 00:22:32,020 --> 00:22:34,323 NOW IN ADDITION TO BEING AN 685 00:22:34,323 --> 00:22:36,692 EXPERT IN PLATONICS, AS MANY CAN 686 00:22:36,692 --> 00:22:38,994 APPRECIATE OVER THE LAST FEW 687 00:22:38,994 --> 00:22:40,395 YEARS, THOSE HOME TESTS THAT WE 688 00:22:40,395 --> 00:22:44,499 USED TO SEE IF WE HAVE BEEN 689 00:22:44,499 --> 00:22:47,069 EXPOSED TO SARS-COV-2 VIRUS, 690 00:22:47,069 --> 00:22:48,770 THESE WERE DEVELOPED AS PART OF 691 00:22:48,770 --> 00:22:52,507 THE RADx PROGRAM AT NIDID AND 692 00:22:52,507 --> 00:22:54,610 WE WOULDN'T BE WHERE WE ARE 693 00:22:54,610 --> 00:22:55,711 TODAY WITHOUT THESE GREAT 694 00:22:55,711 --> 00:22:57,613 EFFORTS AND THIS IS A GREAT 695 00:22:57,613 --> 00:22:58,814 RECOGNITION OF THOSE 696 00:22:58,814 --> 00:22:59,514 CONTRIBUTIONS. 697 00:22:59,514 --> 00:23:03,719 AND THEN FINALLY, DR. EVE MARTYR 698 00:23:03,719 --> 00:23:05,387 WAS AWARDED THE NATIONAL MEDAL 699 00:23:05,387 --> 00:23:09,324 OF SCIENCE, HIGHEST AWARD GIVEN 700 00:23:09,324 --> 00:23:10,025 TO SCIENTISTS IN THE UNITED 701 00:23:10,025 --> 00:23:11,660 STATES OF AMERICA. 702 00:23:11,660 --> 00:23:16,431 EVE HAS BEEN A PIONEER IN 703 00:23:16,431 --> 00:23:20,135 ESTABLISHING MODEL SYSTEMS USING 704 00:23:20,135 --> 00:23:22,337 INVERTEBRATE MODEL SYSTEMS AND 705 00:23:22,337 --> 00:23:25,107 HAS BEEN ABLE TO SHOW WITH THIS, 706 00:23:25,107 --> 00:23:27,643 GENERAL PRINCIPLES ABOUT THE 707 00:23:27,643 --> 00:23:30,812 CONSTRUCTION OF NEUROCIRCUITS, 708 00:23:30,812 --> 00:23:32,414 PLASTICITY OF NEUROCIRCUITS AND 709 00:23:32,414 --> 00:23:34,616 SHOWING US THAT NATURE HAS FOUND 710 00:23:34,616 --> 00:23:36,084 WITHIN A GIVEN CIRCUIT, 711 00:23:36,084 --> 00:23:37,219 DIFFERENT WAYS TO COME UP WITH 712 00:23:37,219 --> 00:23:39,054 THE SOLUTIONS FOR HOW TO TAKE 713 00:23:39,054 --> 00:23:41,123 THESE COMPUTATIONS AND WHAT WAS 714 00:23:41,123 --> 00:23:44,126 REALLY QUITE REMARKABLE IS HOW 715 00:23:44,126 --> 00:23:46,128 BROADLY APPLICABLE THE 716 00:23:46,128 --> 00:23:48,530 PRINCIPLES SHE DISCOVERED TO ALL 717 00:23:48,530 --> 00:23:50,032 NEUROCIRCUITS ACROSS THE ANIMAL 718 00:23:50,032 --> 00:23:50,432 KINGDOM. 719 00:23:50,432 --> 00:23:54,136 AND SO, EVE HAS BEEN A 720 00:23:54,136 --> 00:23:56,238 LONGSTANDING CONTRIBUTOR TO THE 721 00:23:56,238 --> 00:23:56,905 BRAIN INITIATIVE. 722 00:23:56,905 --> 00:23:58,206 SHE WAS A LONGSTANDING MEMBER OF 723 00:23:58,206 --> 00:24:00,208 THIS GROUP, THE MULTI-COUNCIL 724 00:24:00,208 --> 00:24:02,911 WORKING GROUP AND ALSO INVOLVED 725 00:24:02,911 --> 00:24:05,013 IN DRAFTING THE BRAIN 2025 726 00:24:05,013 --> 00:24:06,448 REPORT WHICH HAS BEEN OUR 727 00:24:06,448 --> 00:24:08,216 GUIDING DOCUMENT SINCE THE 728 00:24:08,216 --> 00:24:09,317 INCEPTION OF THE BRAIN 729 00:24:09,317 --> 00:24:09,951 INITIATIVE. 730 00:24:09,951 --> 00:24:11,820 SO CONGRATULATIONS TO EVE. 731 00:24:11,820 --> 00:24:14,322 OKAY, A COUPLE OF EVENTS RECAP 732 00:24:14,322 --> 00:24:17,125 AND COMING EVENTS. 733 00:24:17,125 --> 00:24:21,329 EARLIER THIS YEAR, NEI HOSTED A 734 00:24:21,329 --> 00:24:23,331 WORKSHOP AND VISUAL 735 00:24:23,331 --> 00:24:24,533 NEUROPLASTICITY EXPLORING 736 00:24:24,533 --> 00:24:25,634 CONCEPTS THAT THE RESEARCHERS 737 00:24:25,634 --> 00:24:28,537 CAN USE TO LEARN ABOUT MECHANISM 738 00:24:28,537 --> 00:24:29,938 PLASTICITY IN THE NERVOUS 739 00:24:29,938 --> 00:24:30,806 SYSTEM. 740 00:24:30,806 --> 00:24:33,308 THERE WERE FOUR WORKSHOPS 741 00:24:33,308 --> 00:24:36,344 SESSIONS THAT INVOLVED OR 742 00:24:36,344 --> 00:24:37,512 FEATURED SEVERAL BRAIN FUNDED 743 00:24:37,512 --> 00:24:40,348 INVESTIGATORS AND IT SHOWS A 744 00:24:40,348 --> 00:24:41,216 WONDERFUL INTERSECTION OF WHAT 745 00:24:41,216 --> 00:24:43,518 WE'RE DOING HERE AT BRAIN AND 746 00:24:43,518 --> 00:24:44,920 TRYING TO UNDERSTAND THE CIRCUIT 747 00:24:44,920 --> 00:24:47,823 MECHANISMS AND PLASTICITY 748 00:24:47,823 --> 00:24:49,124 UNDERLYING THESE DIFFERENT 749 00:24:49,124 --> 00:24:49,424 SYSTEMS. 750 00:24:49,424 --> 00:24:51,426 SO IF YOU GO TO THE WEBSITE OR 751 00:24:51,426 --> 00:24:55,030 SCAN THE QR CODE, YOU CAN SEE 752 00:24:55,030 --> 00:24:57,232 THE RECORDED VERSION THERE. 753 00:24:57,232 --> 00:24:59,201 COMING UP, THE ALLEN INSTITUTE 754 00:24:59,201 --> 00:25:01,636 IS HOSTING A MODELING SOFTWARE 755 00:25:01,636 --> 00:25:01,937 WORKSHOP. 756 00:25:01,937 --> 00:25:03,805 THIS IS FUNDED IN PART BY THE 757 00:25:03,805 --> 00:25:05,674 BRAIN INITIATIVE THROUGH OUR 758 00:25:05,674 --> 00:25:06,174 DISSEM NATION PROGRAM. 759 00:25:06,174 --> 00:25:07,409 AND HERE THE PARTICIPANTS WILL 760 00:25:07,409 --> 00:25:09,845 LEARN HOW TO USE OPEN-SOURCE 761 00:25:09,845 --> 00:25:11,947 SOFTWARE AND MODELING TOOLS TO 762 00:25:11,947 --> 00:25:14,850 BUILD, SIMULATION AND DIGITALIZE 763 00:25:14,850 --> 00:25:15,784 MODELS OF BRAIN CIRCUITS. 764 00:25:15,784 --> 00:25:18,220 YOU CAN APPLY, APPLICATION 765 00:25:18,220 --> 00:25:19,821 DEADLINE IS MARCH 15. 766 00:25:19,821 --> 00:25:21,323 IT'S OPEN TO UNDERGRADUATE 767 00:25:21,323 --> 00:25:22,357 STUDENTS AND GRADUATE STUDENTS 768 00:25:22,357 --> 00:25:24,826 AND OTHER SCIENTISTS AS WELL. 769 00:25:24,826 --> 00:25:27,329 AND LAST BUT NOT LEAST, WE ARE 770 00:25:27,329 --> 00:25:30,432 REALLY EXCITED BY THE UPCOMING 771 00:25:30,432 --> 00:25:30,932 BRAIN INITIATIVE ANNUAL 772 00:25:30,932 --> 00:25:32,434 CONFERENCE WHICH WILL BE OUR 773 00:25:32,434 --> 00:25:33,335 TENTH ANNUAL CONFERENCE. 774 00:25:33,335 --> 00:25:34,236 SO PLEASE JOIN US. 775 00:25:34,236 --> 00:25:36,037 IT WILL BE A HYBRID EVENT. 776 00:25:36,037 --> 00:25:38,940 THE IN-PERSON COMPONENT WILL 777 00:25:38,940 --> 00:25:41,243 TAKE PLACE IN NORTH BETHESDA. 778 00:25:41,243 --> 00:25:43,945 THE MAIN CONFERENCE WILL TAKE 779 00:25:43,945 --> 00:25:45,847 PLACE FROM JUNE 17 AND JUNE 18 780 00:25:45,847 --> 00:25:48,049 AND THERE WILL BE AN EARLY 781 00:25:48,049 --> 00:25:50,051 CAREER EVENT THE SUNDAY EVENING 782 00:25:50,051 --> 00:25:50,886 BEFORE. 783 00:25:50,886 --> 00:25:52,053 MARK YOUR CALENDARS, SCAN THE QR 784 00:25:52,053 --> 00:25:54,556 CODE AND GO ON TO OUR WEBSITE. 785 00:25:54,556 --> 00:25:55,123 REGISTER THERE. 786 00:25:55,123 --> 00:25:57,159 IT'S SHAPING UP TO BE A TERRIFIC 787 00:25:57,159 --> 00:25:58,660 CONFERENCE AND THERE WILL BE 788 00:25:58,660 --> 00:25:59,728 MORE INFORMATION COMING AS WE 789 00:25:59,728 --> 00:26:02,464 SORT OUT THE FINAL DETAILS. 790 00:26:02,464 --> 00:26:05,066 OKAY, SO LET ME GIVE YOU SOME 791 00:26:05,066 --> 00:26:06,668 UPDATES ON WHAT WE HAVE BEEN UP 792 00:26:06,668 --> 00:26:08,270 TO OR WHAT OUR FUNDED FOLKS HAVE 793 00:26:08,270 --> 00:26:09,070 BEEN UP TO. 794 00:26:09,070 --> 00:26:13,441 AND I'LL JUST HIGHLIGHT HERE THE 795 00:26:13,441 --> 00:26:15,677 RECENT ADVANCES IN THE RAREST 796 00:26:15,677 --> 00:26:17,646 BRAIN FUNDED CONSORTIA. 797 00:26:17,646 --> 00:26:18,847 NOW I'LL HIGHLIGHT WHAT IS GOING 798 00:26:18,847 --> 00:26:20,715 ON IN THE CELL CENSUS PROJECT AS 799 00:26:20,715 --> 00:26:23,051 WELL AS THE ARMITARIAN PROJECT 800 00:26:23,051 --> 00:26:23,351 HERE. 801 00:26:23,351 --> 00:26:26,254 SO THE BRAIN INITIATIVE CELL 802 00:26:26,254 --> 00:26:27,455 CENSUS PROJECT BASICALLY COVERS 803 00:26:27,455 --> 00:26:29,157 THREE PHASES. 804 00:26:29,157 --> 00:26:33,795 FROM 2014-2017, WAS THE 805 00:26:33,795 --> 00:26:35,463 SO-CALLED BRAIN INITIATIVE CELL 806 00:26:35,463 --> 00:26:36,064 CONSORTIUM. 807 00:26:36,064 --> 00:26:37,732 10 PROJECTS WAS FUNDED AND I WAS 808 00:26:37,732 --> 00:26:39,634 ONE OF THOSE LUCKY PIs IN THAT 809 00:26:39,634 --> 00:26:40,769 FIRST PHASE. 810 00:26:40,769 --> 00:26:44,472 AND OUR REMIT WAS TO DEVELOP, 811 00:26:44,472 --> 00:26:47,909 IDENTIFY AND VALIDATE TOOLS THAT 812 00:26:47,909 --> 00:26:50,645 COULD BE SCALED UP TO CREATE 813 00:26:50,645 --> 00:26:52,247 COMPREHENSIVE ATLASES OF CELL 814 00:26:52,247 --> 00:26:53,982 TYPES IN THE MAMMALIAN BRAIN. 815 00:26:53,982 --> 00:26:56,251 AND THAT QUICKLY SCALED UP TO 816 00:26:56,251 --> 00:26:58,386 THE BRAIN INITIATIVE CELL CENSUS 817 00:26:58,386 --> 00:27:00,255 NETWORK WHERE THE GOAL WAS 818 00:27:00,255 --> 00:27:02,557 ASPIRATIONAL AT THE TIME BUT THE 819 00:27:02,557 --> 00:27:05,093 GOAL WAS TO CHANGE THE WAY THAT 820 00:27:05,093 --> 00:27:06,461 WE CAN CLASSIFY BRAIN CELL TYPES 821 00:27:06,461 --> 00:27:09,564 BASED ON INTEGRATIVE ANALYSIS OF 822 00:27:09,564 --> 00:27:12,467 THE MOLECULAR AND PHYSIOLOGICAL 823 00:27:12,467 --> 00:27:12,767 PROPERTIES. 824 00:27:12,767 --> 00:27:13,835 THE BEDROCK OF THE CELL CENSUS 825 00:27:13,835 --> 00:27:15,170 PROJECT HAS BEEN AND WILL 826 00:27:15,170 --> 00:27:17,372 CONTINUE TO BE ON SINGLE CELL 827 00:27:17,372 --> 00:27:18,773 TRANSCRIPTOMICS BUT IT'S MUCH, 828 00:27:18,773 --> 00:27:20,242 MUCH MORE THAN THAT. 829 00:27:20,242 --> 00:27:21,376 THERE ARE MANY MORE MODALITIES 830 00:27:21,376 --> 00:27:23,645 TO GIVE US INTEGRATED VIEW. 831 00:27:23,645 --> 00:27:26,848 THE BICCN WRAPPED UP IN 2022. 832 00:27:26,848 --> 00:27:29,150 IT RAN FOR FIVE YEARS. 833 00:27:29,150 --> 00:27:30,952 AND THAT HAS GIVEN WAY TO WHAT 834 00:27:30,952 --> 00:27:34,456 IS NOW THE BRAIN INITIATIVE CELL 835 00:27:34,456 --> 00:27:35,557 ATLAS NETWORK. 836 00:27:35,557 --> 00:27:38,260 ONE OF OUR PROJECTS THAT WILL BE 837 00:27:38,260 --> 00:27:39,761 RUNNING FOR THE NEXT FIVE YEARS 838 00:27:39,761 --> 00:27:40,662 THROUGH 2027. 839 00:27:40,662 --> 00:27:42,163 AND THE THEME THROUGH ALL THIS 840 00:27:42,163 --> 00:27:44,866 WAS A MANTRA, AND NOBODY SEEMS 841 00:27:44,866 --> 00:27:45,800 TO TAKE CREDIT FOR COMING UP 842 00:27:45,800 --> 00:27:48,136 WITH IT, BUT IT'S THINK BIG, 843 00:27:48,136 --> 00:27:50,205 START SMALL AND SCALE FAST. 844 00:27:50,205 --> 00:27:51,806 SO, I JUST WANT TO SUMMARIZE 845 00:27:51,806 --> 00:27:53,675 SOME REMARKABLE PUBLICATIONS 846 00:27:53,675 --> 00:27:55,277 THAT CAME OUT OF THIS. 847 00:27:55,277 --> 00:27:59,581 IN OCTOBER 2021, 27 PAPERS WERE 848 00:27:59,581 --> 00:28:01,883 PUBLISHED IN NATURE FAMILY 849 00:28:01,883 --> 00:28:02,150 JOURNALS. 850 00:28:02,150 --> 00:28:05,153 AS A PILOT PROJECT, USING THE 851 00:28:05,153 --> 00:28:08,857 PRIMARY MOTOR CORTEX OF THE -- 852 00:28:08,857 --> 00:28:10,358 ACROSS MAMMALIAN SPECIES TO SEE 853 00:28:10,358 --> 00:28:12,460 IF WE COULD DO IT, AND THEN 854 00:28:12,460 --> 00:28:14,896 FINALLY THIS GAVE RISE TO A 855 00:28:14,896 --> 00:28:16,364 WHOLE MOUSE BRAIN CELL ATLAS 856 00:28:16,364 --> 00:28:18,366 THAT WAS RECENTLY PUBLISHED IN 857 00:28:18,366 --> 00:28:19,734 10 ARTICLES IN THE DECEMBER 858 00:28:19,734 --> 00:28:21,670 ISSUE OF NATURE, 9 OF WHICH WERE 859 00:28:21,670 --> 00:28:31,913 BRAIN FUNDED. 860 00:28:34,749 --> 00:28:36,584 SO I'LL GO THROUGH THESE VERY 861 00:28:36,584 --> 00:28:37,052 QUICKLY. 862 00:28:37,052 --> 00:28:39,087 IN THE SO-CALLED PILOT PROJECT, 863 00:28:39,087 --> 00:28:43,291 THE BICCN PUBLISHED THE CELL 864 00:28:43,291 --> 00:28:45,961 CENSUS ANALYSIS IN THE MOTOR 865 00:28:45,961 --> 00:28:50,298 CORTEX IN MULTIPLE MAMMALIAN 866 00:28:50,298 --> 00:28:51,533 SPECIES WITH SPACIAL 867 00:28:51,533 --> 00:28:52,734 DISTRIBUTION AND PHYSIOLOGY 868 00:28:52,734 --> 00:28:54,569 CONNECTIVITY. 869 00:28:54,569 --> 00:28:56,972 THIS REALLY WAS A -- ORGANIZED 870 00:28:56,972 --> 00:29:00,075 250 RESEARCHERS ACROSS THREE 871 00:29:00,075 --> 00:29:01,209 CONTINENTS FROM OVER 45 872 00:29:01,209 --> 00:29:01,543 INSTITUTIONS. 873 00:29:01,543 --> 00:29:03,378 AND IT REALLY SET THE STAGE FOR 874 00:29:03,378 --> 00:29:05,046 LARGER MORE COMPREHENSIVE AT LAT 875 00:29:05,046 --> 00:29:06,982 FOR THE ENTIRE MOUSE BRAIN AND 876 00:29:06,982 --> 00:29:09,284 ALSO SET THE STAGE FOR STANDING 877 00:29:09,284 --> 00:29:10,986 UP THE EFFORTS TO GET INTO THE 878 00:29:10,986 --> 00:29:12,887 BIG BRAINS AND WE COULD ALREADY 879 00:29:12,887 --> 00:29:14,956 SEE THESE HIERARCHAL 880 00:29:14,956 --> 00:29:15,790 RELATIONSHIPS BETWEEN THE CELL 881 00:29:15,790 --> 00:29:17,192 TYPES AND HOW THEY ARE 882 00:29:17,192 --> 00:29:17,459 ORGANIZED. 883 00:29:17,459 --> 00:29:21,396 IN THIS TINY PIECE OF THE 884 00:29:21,396 --> 00:29:21,629 CORTEX. 885 00:29:21,629 --> 00:29:23,198 SO AGAIN AS I MENTIONED, AT THE 886 00:29:23,198 --> 00:29:26,234 END OF LAST YEAR, THE GROUP 887 00:29:26,234 --> 00:29:28,069 PUBLISHED A COMPREHENSIVE ATLAS 888 00:29:28,069 --> 00:29:30,305 OF THE ENTIRE MOUSE BRAIN. 889 00:29:30,305 --> 00:29:33,308 AND THIS ANALYSIS COVERED OVER 890 00:29:33,308 --> 00:29:35,610 32 MILLION CELLS. 891 00:29:35,610 --> 00:29:36,878 THERE WERE PROFILED USING A 892 00:29:36,878 --> 00:29:38,446 COMBINATION OF HIGH RESOLUTION 893 00:29:38,446 --> 00:29:39,714 SINGLE CELLTECHNIQUE. 894 00:29:39,714 --> 00:29:41,616 I SHOULD MENTION IN 2014 WHEN WE 895 00:29:41,616 --> 00:29:43,084 STARTED THIS EFFORT, IF YOU HAD 896 00:29:43,084 --> 00:29:46,688 A STUDY THAT COVERED 1000 SINGLE 897 00:29:46,688 --> 00:29:47,489 CELLS YOU WERE AHEAD OF THE 898 00:29:47,489 --> 00:29:48,823 PACK. 899 00:29:48,823 --> 00:29:49,591 IT'S JUST ASTOUNDING THE 900 00:29:49,591 --> 00:29:50,492 PROGRESS WE MADE IN TERMS OF 901 00:29:50,492 --> 00:29:52,694 COST AND EFFICIENCY BETWEEN IN 902 00:29:52,694 --> 00:29:55,630 THE LAST 10 YEARS. 903 00:29:55,630 --> 00:29:57,932 THE GROUP IDENTIFIED USING 904 00:29:57,932 --> 00:29:59,601 SINGLE CELL TRANSCRIPTOMICS, 905 00:29:59,601 --> 00:30:01,302 5300 DISTINCT CELL TYPES AND I 906 00:30:01,302 --> 00:30:04,139 USE THE WORD TYPES GUARDEDLY. 907 00:30:04,139 --> 00:30:05,340 JUST DISTINGUISHABLE TYPES OF 908 00:30:05,340 --> 00:30:05,607 CELLS. 909 00:30:05,607 --> 00:30:07,942 AND REVEALED THE ORGANIZATION OF 910 00:30:07,942 --> 00:30:09,277 PRINCIPLES UNDERLYING 911 00:30:09,277 --> 00:30:10,912 DIVERSIFICATION OF BRAIN CELL 912 00:30:10,912 --> 00:30:13,415 TYPES AND PERHAPS SURPRISINGLY 913 00:30:13,415 --> 00:30:15,350 THEY FOUND A HIGHER COMPLEXITY 914 00:30:15,350 --> 00:30:16,718 OF CELL TYPES IN THE OLD PARTS 915 00:30:16,718 --> 00:30:20,555 OF THE BRAIN COMPARED TO SAY THE 916 00:30:20,555 --> 00:30:21,823 NEOCORTEX. 917 00:30:21,823 --> 00:30:24,626 THIS PROBABLY REFLECTS THE 918 00:30:24,626 --> 00:30:25,226 EVOLUTIONARY AGE OF THE 919 00:30:25,226 --> 00:30:27,362 DIFFERENT PARTS OF THE BRAIN. 920 00:30:27,362 --> 00:30:28,696 SO MAJOR TAKEAWAYS BASED ON 921 00:30:28,696 --> 00:30:32,233 SINGLE CELL TRANSCRIPTOMICS, 922 00:30:32,233 --> 00:30:34,636 OVER 5000 DISTINGUISHABLE CELL 923 00:30:34,636 --> 00:30:36,438 TYPES AND THEN DURING THIS TIME 924 00:30:36,438 --> 00:30:41,376 THERE WAS ANOTHER MINIREVOLUTION 925 00:30:41,376 --> 00:30:42,243 IN SPACIAL TRANSCRIPTOMICS 926 00:30:42,243 --> 00:30:44,546 ALLOWING RESEARCHERS TO MAP 927 00:30:44,546 --> 00:30:46,281 THESE ALLEGEDDED CELL TYPES ON 928 00:30:46,281 --> 00:30:48,149 TO SPACE IN THESE BRAINS AND IN 929 00:30:48,149 --> 00:30:50,385 MANY WAYS PROVIDING MORE 930 00:30:50,385 --> 00:30:51,653 INFORMATION ABOUT THOSE CELLS, 931 00:30:51,653 --> 00:30:54,255 AND ALSO VALIDATING THEIR 932 00:30:54,255 --> 00:30:55,657 IDENTITY AS REAL CELL TYPES. 933 00:30:55,657 --> 00:30:56,958 AND THE ALSO THERE WAS A VERY 934 00:30:56,958 --> 00:30:59,260 LARGE EFFORT LOOKING AT THE 935 00:30:59,260 --> 00:31:00,328 EPIGENOMIC PROFILES OF THESE 936 00:31:00,328 --> 00:31:03,531 CELLS AND THIS COMBINED WITH THE 937 00:31:03,531 --> 00:31:05,433 RNA INFORMATION AND OTHER 938 00:31:05,433 --> 00:31:06,734 MEASURES, REALLY GIVES US AN 939 00:31:06,734 --> 00:31:09,971 IDEA ABOUT THE REGULATORY 940 00:31:09,971 --> 00:31:11,406 MECHANISMS THAT SHAPE THESE 941 00:31:11,406 --> 00:31:14,876 DIFFERENT CELLULAR IDENTITIES. 942 00:31:14,876 --> 00:31:17,045 AND THIS PRONOUNCED SUBSEQUENT 943 00:31:17,045 --> 00:31:19,380 FUNCTIONAL STUDIES WE ARE 944 00:31:19,380 --> 00:31:20,381 LOOKING FORWARD TO IN THE 945 00:31:20,381 --> 00:31:20,615 FUTURE. 946 00:31:20,615 --> 00:31:22,150 AND THEN FOLLOWING UP, I'LL 947 00:31:22,150 --> 00:31:26,154 MENTION BRIEFLY, THE DRAFT HUMAN 948 00:31:26,154 --> 00:31:29,057 AND NON-HUMAN PRIMATE BRAIN CELL 949 00:31:29,057 --> 00:31:30,792 ATLASES PUBLISHED IN THE SCIENCE 950 00:31:30,792 --> 00:31:32,794 MAGAZINE FAMILY OF JOURNALS. 951 00:31:32,794 --> 00:31:34,496 IT MAPPED DETAIL AND 952 00:31:34,496 --> 00:31:36,164 COMPLEXITIES OF THESE CELL TYPES 953 00:31:36,164 --> 00:31:37,265 ACROSS SPACE, SPECIES AND TIME. 954 00:31:37,265 --> 00:31:38,766 AND REALLY PAVES THE ROAD 955 00:31:38,766 --> 00:31:40,602 TOWARDS A GREATER UNDERSTANDING 956 00:31:40,602 --> 00:31:42,070 OF THE HUMAN BRAIN AT THE 957 00:31:42,070 --> 00:31:46,141 CELLULAR LEVEL IN MODELS IN 958 00:31:46,141 --> 00:31:46,908 HEALTH AND DISEASE. 959 00:31:46,908 --> 00:31:49,777 SO IT DOES USHER IN A NEW ERA OF 960 00:31:49,777 --> 00:31:50,979 HUMAN BRAIN RESEARCH ACROSS 961 00:31:50,979 --> 00:31:51,412 SPACE. 962 00:31:51,412 --> 00:31:54,682 SO USING SINGLE CELL 963 00:31:54,682 --> 00:31:56,251 TRANSCRIPTOMICS TOGETHER WITH 964 00:31:56,251 --> 00:31:56,818 SPACIOUS TRANSCRIPTOMICS AND 965 00:31:56,818 --> 00:31:58,453 ACROSS SPECIES. 966 00:31:58,453 --> 00:32:02,290 SO THE GROUP LOOKED AT BRAINS 967 00:32:02,290 --> 00:32:03,858 FROM HUMANS AS WELL AS OUR 968 00:32:03,858 --> 00:32:06,361 NEAREST RELATIVES AND OTHER 969 00:32:06,361 --> 00:32:07,095 NON-HUMAN PRIMATES. 970 00:32:07,095 --> 00:32:08,863 WE ARE CLOSEST IN TERMS OF CELL 971 00:32:08,863 --> 00:32:10,265 TYPES WITH THE GREAT APES. 972 00:32:10,265 --> 00:32:11,299 THAT'S NOT TOO SURPRISING. 973 00:32:11,299 --> 00:32:13,568 WHAT IS REALLY INTERESTING IF 974 00:32:13,568 --> 00:32:15,303 YOU NOW LOOK AT THE GENES THAT 975 00:32:15,303 --> 00:32:18,773 SHOW THE HIGHEST 976 00:32:18,773 --> 00:32:20,175 DIFFERENTIALLY -- DIFFERENTIAL 977 00:32:20,175 --> 00:32:21,476 REGULATION, SO THE 978 00:32:21,476 --> 00:32:23,178 DIFFERENTIALLY EXPRESSED GENES, 979 00:32:23,178 --> 00:32:25,914 THESE TEND TO BE LINKED WITH 980 00:32:25,914 --> 00:32:27,815 HUMAN ACCELERATED CHANGES AND 981 00:32:27,815 --> 00:32:30,718 THEY TEND TO ENCODE GENES OF 982 00:32:30,718 --> 00:32:31,486 SYNAPTIC PROTEINS. 983 00:32:31,486 --> 00:32:33,354 SO WE CAN REALLY THINK ABOUT NOT 984 00:32:33,354 --> 00:32:35,590 SO MUCH WHAT IS THE SAME BETWEEN 985 00:32:35,590 --> 00:32:36,791 THESE SPECIES BUT WHAT IS 986 00:32:36,791 --> 00:32:38,993 DIFFERENT AND GET INSIGHTS INTO 987 00:32:38,993 --> 00:32:40,295 WHAT GIVES RICE TO DIFFERENT 988 00:32:40,295 --> 00:32:42,130 PROPERTIES OF BRAINS AGAINST THE 989 00:32:42,130 --> 00:32:43,331 DIFFERENT PRIMATE SPECIES. 990 00:32:43,331 --> 00:32:45,400 AND THEN THE GROUP STARTED AN 991 00:32:45,400 --> 00:32:47,602 ANALYSIS ACROSS THE LIFESPAN OF 992 00:32:47,602 --> 00:32:48,937 BOTH DURING DEVELOPMENT AS WELL 993 00:32:48,937 --> 00:32:50,305 AS IN THE AGING ANIMALS. 994 00:32:50,305 --> 00:32:53,007 THIS AGAIN GIVES US A BEDROCK 995 00:32:53,007 --> 00:32:54,709 INFORMATION THAT COULD BE USED 996 00:32:54,709 --> 00:32:56,844 TO UNDERSTAND DEVELOPMENTAL 997 00:32:56,844 --> 00:32:57,612 DISORDERS AS WELL AS DISORDERS 998 00:32:57,612 --> 00:32:59,914 ASSOCIATED WITH AGING. 999 00:32:59,914 --> 00:33:01,449 SO THIS SETS THE STAGE FOR THE 1000 00:33:01,449 --> 00:33:03,318 BRAIN INITIATIVE CELL AT LAT 1001 00:33:03,318 --> 00:33:04,619 NETWORK WHICH IS UNDERWAY RIGHT 1002 00:33:04,619 --> 00:33:07,322 NOW AND ONE OF OUR 1003 00:33:07,322 --> 00:33:09,424 TRANSFORMATIVE PROJECTS. 1004 00:33:09,424 --> 00:33:10,625 RECENTLY EARLIER THIS YEAR, WE 1005 00:33:10,625 --> 00:33:12,527 HAD A WORKSHOP ON DATA 1006 00:33:12,527 --> 00:33:13,928 INTEGRATION AND ADAPTATION BASED 1007 00:33:13,928 --> 00:33:15,897 ON WHAT IS COMING, WHAT HAS 1008 00:33:15,897 --> 00:33:19,334 ALREADY COME OUT OF THE BICCN. 1009 00:33:19,334 --> 00:33:25,306 AND BASED ON THE FOUNDATION, THE 1010 00:33:25,306 --> 00:33:26,741 WORKSHOP EXPLORED THE 1011 00:33:26,741 --> 00:33:28,142 OPPORTUNITIES AND CHALLENGES TO 1012 00:33:28,142 --> 00:33:29,344 BUILD A KNOWLEDGE BASE 1013 00:33:29,344 --> 00:33:31,412 RESEARCHERS COULD USE AS A 1014 00:33:31,412 --> 00:33:33,014 REFERENCE RESOURCE TO GUIDE A 1015 00:33:33,014 --> 00:33:34,949 WIDE RANGE OF INQUIRIES INTO THE 1016 00:33:34,949 --> 00:33:36,551 FUNCTIONAL PROPERTIES OF 1017 00:33:36,551 --> 00:33:37,051 NEUROCIRCUITRY. 1018 00:33:37,051 --> 00:33:38,419 THIS HAS BEEN RECORDED AND IT'S 1019 00:33:38,419 --> 00:33:39,821 A TERRIFIC MEETING OF THE MINDS 1020 00:33:39,821 --> 00:33:42,023 TO REALLY UNDERSTAND WHAT NEEDS 1021 00:33:42,023 --> 00:33:44,559 TO BE DONE AND HOW WE MIGHT GO 1022 00:33:44,559 --> 00:33:46,227 ABOUT ACHIEVING IT. 1023 00:33:46,227 --> 00:33:47,895 SO JUST WANT TO TOUCH BASE ON 1024 00:33:47,895 --> 00:33:50,365 WHERE WE ARE ON THE ARMATARIUM 1025 00:33:50,365 --> 00:33:52,233 FOR PRECISION BRAIN CELL ACCESS 1026 00:33:52,233 --> 00:33:52,467 PROJECT. 1027 00:33:52,467 --> 00:33:54,335 THE GOAL IS TO DEVELOP TOOLS TO 1028 00:33:54,335 --> 00:33:56,638 ALLOW RESEARCHERS TO ACCESS 1029 00:33:56,638 --> 00:33:59,340 MANIPULATE AND MODEL CLINICALLY 1030 00:33:59,340 --> 00:34:00,508 RELEVANT CELL TYPES ACROSS 1031 00:34:00,508 --> 00:34:01,943 MULTIPLE SPECIES. 1032 00:34:01,943 --> 00:34:04,746 THIS IS THE FROM THE BRAIN 2.0 1033 00:34:04,746 --> 00:34:04,979 REPORT. 1034 00:34:04,979 --> 00:34:08,449 THE PROJECT, THINK OF IT AS 1035 00:34:08,449 --> 00:34:10,418 THREE INTERLOCKED AREAS, 1036 00:34:10,418 --> 00:34:11,919 DEVELOPING NEW ACCESS TOOLS, WE 1037 00:34:11,919 --> 00:34:14,322 FUNDED 6 PRIVATE PROJECTS TO 1038 00:34:14,322 --> 00:34:16,324 DESIGN DELIVERY VECTORS AND GENE 1039 00:34:16,324 --> 00:34:19,227 REGULATORY ELEMENTS TO PRECISELY 1040 00:34:19,227 --> 00:34:20,261 TARGET PAYLOADS INTO DIFFERENT 1041 00:34:20,261 --> 00:34:22,830 CELL TYPES AND THESE PAYLOADS 1042 00:34:22,830 --> 00:34:25,733 CAN EITHER BE OPT GENETIC 1043 00:34:25,733 --> 00:34:27,902 SWITCHES, SENSORS OR GENE 1044 00:34:27,902 --> 00:34:28,236 EDITORS. 1045 00:34:28,236 --> 00:34:30,438 AND THEN IT WILL BE IMPORTANT TO 1046 00:34:30,438 --> 00:34:31,506 DISSEMINATE THESE REGIONS OUT 1047 00:34:31,506 --> 00:34:33,941 INTO THE FIELD. 1048 00:34:33,941 --> 00:34:36,444 I'LL GIVE YOU A BRIEF UPDATE ON 1049 00:34:36,444 --> 00:34:36,644 THAT. 1050 00:34:36,644 --> 00:34:39,547 WE SO FAR FUNDED SIX OF THESE 1051 00:34:39,547 --> 00:34:40,281 PILOT PROJECTS. 1052 00:34:40,281 --> 00:34:43,584 IT TURNED OUT THEY ARE FOLK UGGS 1053 00:34:43,584 --> 00:34:46,054 THEIR EFFORTS ON DEVELOPING 1054 00:34:46,054 --> 00:34:47,655 ADENO-ASSOCIATED VIRUS AS A 1055 00:34:47,655 --> 00:34:50,658 VECTOR AND THE EFFORTS HAVE BEEN 1056 00:34:50,658 --> 00:34:52,560 CONCENTRATING ON USING REALLY 1057 00:34:52,560 --> 00:34:56,364 COOL DIRECTED EVOLUTION IN AI 1058 00:34:56,364 --> 00:34:59,867 APPROACHES IN ENGINEERING TO 1059 00:34:59,867 --> 00:35:02,770 FINE-TUNE THE VIRUS AND THEN TO 1060 00:35:02,770 --> 00:35:05,540 FURTHER SPECIFY CELL TYPE 1061 00:35:05,540 --> 00:35:06,374 SPECIFIC GENE EXPRESSION USING 1062 00:35:06,374 --> 00:35:07,375 DATA AND INFORMATION COMING FROM 1063 00:35:07,375 --> 00:35:09,777 THE CELL CENSUS PROJECT TO 1064 00:35:09,777 --> 00:35:11,679 IDENTIFY AND VALIDATE GENE 1065 00:35:11,679 --> 00:35:15,516 REGULATORY ELEMENTS THAT CAN 1066 00:35:15,516 --> 00:35:16,084 CROAK GENE EXPRESSION IN THE 1067 00:35:16,084 --> 00:35:19,187 CELL TYPES SPECIFIC WAY OF THE 1068 00:35:19,187 --> 00:35:19,654 PAYLOADS. 1069 00:35:19,654 --> 00:35:22,156 AND ALREADY WE HAVE BEEN MAKING 1070 00:35:22,156 --> 00:35:23,057 REMARKABLE PROGRESS AS EVIDENCE 1071 00:35:23,057 --> 00:35:26,394 OF THIS COLLECTION OF 1072 00:35:26,394 --> 00:35:26,728 PUBLICATIONS. 1073 00:35:26,728 --> 00:35:32,300 WE HAVE PENDING UN1 AWARDS 1074 00:35:32,300 --> 00:35:34,369 COMING OUT FOR DEVELOPING 1075 00:35:34,369 --> 00:35:35,770 PAYLOADS AND INTEGRATION WITH 1076 00:35:35,770 --> 00:35:39,674 THESE OTHER EFFORTS AND 1077 00:35:39,674 --> 00:35:41,075 DISSEMINATION PROGRAMS. 1078 00:35:41,075 --> 00:35:42,610 U24 DISSEMINATION PROJECTS THAT 1079 00:35:42,610 --> 00:35:44,712 ARE TARGETED TO AN ALREADY 1080 00:35:44,712 --> 00:35:47,281 SERVING INSTITUTIONS AND IN 1081 00:35:47,281 --> 00:35:51,119 COLLABORATION WITH OUR U01 PILOT 1082 00:35:51,119 --> 00:35:51,386 PROJECTS. 1083 00:35:51,386 --> 00:35:54,188 WE ALREADY HAVE THESE 1084 00:35:54,188 --> 00:35:58,893 COLLABORATIONS BETWEEN 1085 00:35:58,893 --> 00:36:00,495 INSTITUTES AND WE HAVE ANOTHER 1086 00:36:00,495 --> 00:36:02,997 COMING UP VERY SOON. 1087 00:36:02,997 --> 00:36:05,833 VERY IMPORTANT TO GET THESE 1088 00:36:05,833 --> 00:36:06,467 TOOLS IDENTITY TO THE FIELD AND 1089 00:36:06,467 --> 00:36:10,571 THERE ARE A NUMBER OF WAYS OF 1090 00:36:10,571 --> 00:36:11,472 ACHIEVING THIS. 1091 00:36:11,472 --> 00:36:16,277 WE HAVE A GROWING COLLECTION IN 1092 00:36:16,277 --> 00:36:17,345 WILD PRODUCTION FACILITIES AND 1093 00:36:17,345 --> 00:36:18,079 CORE FACILITIES STOOD UP AS 1094 00:36:18,079 --> 00:36:21,582 THESE INSTITUTIONS I JUST 1095 00:36:21,582 --> 00:36:21,849 MENTIONED. 1096 00:36:21,849 --> 00:36:24,419 SO JUST BRIEFLY I WANT TO TO GO 1097 00:36:24,419 --> 00:36:27,722 THROUGH A FEW BRAIN FUNDING 1098 00:36:27,722 --> 00:36:28,055 OPPORTUNITIES. 1099 00:36:28,055 --> 00:36:30,091 THIS THE IS IN BRAIN AS 1100 00:36:30,091 --> 00:36:31,893 PARTICIPATING IN THE COMMON 1101 00:36:31,893 --> 00:36:35,196 SOMATIC CELL GENOME EDITING 1102 00:36:35,196 --> 00:36:35,596 CONSORTIUM. 1103 00:36:35,596 --> 00:36:37,198 THE TARGETED CHALLENGE HERE IS 1104 00:36:37,198 --> 00:36:40,601 TO FIND NEW WAYS OF DEVISING 1105 00:36:40,601 --> 00:36:42,003 PROGRAMMABLE DELIVERY SYSTEMS 1106 00:36:42,003 --> 00:36:45,773 FOR GENE EDITING AS WELL AS TO 1107 00:36:45,773 --> 00:36:47,141 FIND NEW VECTORS FOR CROSSING 1108 00:36:47,141 --> 00:36:48,409 THE BLOOD-BRAIN BARRIER. 1109 00:36:48,409 --> 00:36:49,444 WE HAVE ALREADY GONE THROUGH 1110 00:36:49,444 --> 00:36:51,512 PHASE I AND WE ARE NOW IN PHASE 1111 00:36:51,512 --> 00:36:53,014 II WHICH REQUIRES PRELIMINARY 1112 00:36:53,014 --> 00:36:55,850 DATA AND PROOF-OF-CONCEPT 1113 00:36:55,850 --> 00:36:57,885 INFORMATION AND THIS WILL BE DUE 1114 00:36:57,885 --> 00:37:00,021 BY -- IT IS OPEN NOW BUT 1115 00:37:00,021 --> 00:37:00,988 REGISTRATION MUST BE DONE BY 1116 00:37:00,988 --> 00:37:02,990 NOVEMBER OF THIS YEAR. 1117 00:37:02,990 --> 00:37:05,326 HERE ISUST JUDGE A SHORT LIST OF 1118 00:37:05,326 --> 00:37:09,096 RECENT REISSUES OF BRAIN NOTICES 1119 00:37:09,096 --> 00:37:11,132 OF FUNDING OPPORTUNITIES. 1120 00:37:11,132 --> 00:37:13,201 WE HAVE A REISSUE OF THE BRAIN 1121 00:37:13,201 --> 00:37:15,069 BEHAVIOR QUANTIFICATION 1122 00:37:15,069 --> 00:37:16,904 SYNCHRONIZATION PROGRAM, THE R34 1123 00:37:16,904 --> 00:37:18,206 PLANNING GRANTS. 1124 00:37:18,206 --> 00:37:22,376 TWO REISSUES FOR THE MARMOSET 1125 00:37:22,376 --> 00:37:24,045 COLMEANS IT FOR NEUROSCIENCE 1126 00:37:24,045 --> 00:37:24,545 RESEARCH. 1127 00:37:24,545 --> 00:37:26,514 THE R021S FOR EARLY STAGE 1128 00:37:26,514 --> 00:37:28,316 RESEARCH FOR RECORDING AND 1129 00:37:28,316 --> 00:37:29,183 MODULATION IN THE NERVOUS SYSTEM 1130 00:37:29,183 --> 00:37:31,352 AS WELL AS A REISSUE OF OUR D 1131 00:37:31,352 --> 00:37:35,022 SPAN F99K00 STAGE GRADUATE 1132 00:37:35,022 --> 00:37:37,892 STUDENT AND POSTDOC AWARDS THAT 1133 00:37:37,892 --> 00:37:41,696 WE ARE PARTICIPATING IN AND 1134 00:37:41,696 --> 00:37:44,232 COLLABORATION WITH OUR SISTER 1135 00:37:44,232 --> 00:37:45,066 PROGRAM, THE BLUEPRINT PROGRAM. 1136 00:37:45,066 --> 00:37:46,400 HERE IS A LIST I THINK YOU ALL 1137 00:37:46,400 --> 00:37:47,301 HAVE SEEN BEFORE. 1138 00:37:47,301 --> 00:37:48,336 I'LL GO THROUGH IT AGAIN. 1139 00:37:48,336 --> 00:37:49,737 THESE ARE TRAINING OPPORTUNITIES 1140 00:37:49,737 --> 00:37:51,806 SUPPORTED BY THE BRAIN 1141 00:37:51,806 --> 00:37:52,106 INITIATIVE. 1142 00:37:52,106 --> 00:37:54,008 THE FIRST SET UNDER THE RED BAR 1143 00:37:54,008 --> 00:37:55,910 ARE THE GENERAL TRAINING. 1144 00:37:55,910 --> 00:37:59,447 WE HAVE F32 PROGRAM. 1145 00:37:59,447 --> 00:38:01,215 K08 CLINICIAN SCIENCE CAREER 1146 00:38:01,215 --> 00:38:02,617 DEVELOPMENT AWARDS AS WELL AS 1147 00:38:02,617 --> 00:38:04,352 OUR R25 SHORT COURSES. 1148 00:38:04,352 --> 00:38:06,521 AND THEN BELOW THE BLUE BAR ARE 1149 00:38:06,521 --> 00:38:09,323 OUR DIVERSITY FOCUSED AWARDS. 1150 00:38:09,323 --> 00:38:12,960 WE HAVE THE -- WE NOW 1151 00:38:12,960 --> 00:38:14,161 PARTICIPATE IN THE BLUEPRINT 1152 00:38:14,161 --> 00:38:15,763 BRAIN PROGRAM, THE INSTITUTIONAL 1153 00:38:15,763 --> 00:38:16,731 R25 PROGRAM. 1154 00:38:16,731 --> 00:38:18,199 WE ARE VERY EXCITED TO BE 1155 00:38:18,199 --> 00:38:20,768 INVOLVED IN THE PIPELINE AT THE 1156 00:38:20,768 --> 00:38:21,736 UNDERGRADUATE RESEARCH LEVEL. 1157 00:38:21,736 --> 00:38:25,907 WE HAVE THE F99K00 AWARDS AND 1158 00:38:25,907 --> 00:38:29,210 OUR DIVERSITY FOCUS K99R00 1159 00:38:29,210 --> 00:38:31,512 AWARDS AND ON A ROLLING BASIS WE 1160 00:38:31,512 --> 00:38:34,482 ACCEPT APPLICATIONS FOR 1161 00:38:34,482 --> 00:38:35,082 ADMINISTRATIVE SUPPLEMENTS TO 1162 00:38:35,082 --> 00:38:37,084 BRING IN FOLKS FROM DIVERSE 1163 00:38:37,084 --> 00:38:37,385 BACKGROUNDS. 1164 00:38:37,385 --> 00:38:39,754 SO AGAIN, YOU CAN GET MORE 1165 00:38:39,754 --> 00:38:40,922 INFORMATION ABOUT THIS EITHER BY 1166 00:38:40,922 --> 00:38:42,223 SCANNING THE QR CODE OR JUST 1167 00:38:42,223 --> 00:38:45,059 GOING TO OUR WEBSITE AND LOOKING 1168 00:38:45,059 --> 00:38:46,928 UP FOR TRAINING OPPORTUNITIES. 1169 00:38:46,928 --> 00:38:47,728 AND THERE ARE ADDITIONAL 1170 00:38:47,728 --> 00:38:48,863 OPPORTUNITIES THROUGH VARIOUS 1171 00:38:48,863 --> 00:38:52,033 NOTICES AND PROGRAMS AROUND NIH. 1172 00:38:52,033 --> 00:38:52,833 THE SCIENCE EDUCATION 1173 00:38:52,833 --> 00:38:55,036 PARTNERSHIP AWARD, THE RESEARCH 1174 00:38:55,036 --> 00:38:57,939 OF ACTIVITIES RELATED TO 1175 00:38:57,939 --> 00:39:00,107 DIVERSITY AWARDS, AS WELL AS 1176 00:39:00,107 --> 00:39:00,775 VARIOUS RESEARCH SUPPLEMENTS 1177 00:39:00,775 --> 00:39:02,743 THAT ARE DESIGNED TO BRING MORE 1178 00:39:02,743 --> 00:39:05,479 FOLKS INTO OR BACK INTO THE 1179 00:39:05,479 --> 00:39:08,449 RESEARCH WORKFORCE. 1180 00:39:08,449 --> 00:39:10,851 OKAY, SO LET ME JUST TAKE THE 1181 00:39:10,851 --> 00:39:13,454 NEXT FEW MINUTES TO COVER SOME 1182 00:39:13,454 --> 00:39:14,655 RECENT COOL PAPERS WE HAVE SEEN 1183 00:39:14,655 --> 00:39:16,257 IN THE LITERATURE THAT HAVE BEEN 1184 00:39:16,257 --> 00:39:18,059 SUPPORTED BY THE BRAIN 1185 00:39:18,059 --> 00:39:18,359 INITIATIVE. 1186 00:39:18,359 --> 00:39:19,760 NOW THERE HAS BEEN AN EXPLOSION 1187 00:39:19,760 --> 00:39:21,729 OF STUDIES IN THE LAST COUPLE OF 1188 00:39:21,729 --> 00:39:23,464 YEARS DEMONSTRATING NEW 1189 00:39:23,464 --> 00:39:24,565 APPLICATIONS OF DEEP BRAIN 1190 00:39:24,565 --> 00:39:25,433 STIMULATION WHICH HAS BEEN 1191 00:39:25,433 --> 00:39:28,636 AROUND FOR DECADES TO TREED 1192 00:39:28,636 --> 00:39:29,470 DISORDERS AND NOW BEING APPLIED 1193 00:39:29,470 --> 00:39:32,473 TO TREAT A WIDE RANGE OF 1194 00:39:32,473 --> 00:39:34,141 NEUROPSYCHIATRIC CONDITIONS 1195 00:39:34,141 --> 00:39:37,311 INCLUDING TREATMENT RESISTANT 1196 00:39:37,311 --> 00:39:40,815 DEPRESSION, OBSESSIVE COMPULSIVE 1197 00:39:40,815 --> 00:39:41,515 BEHAVIORS, BINGE EATING DISCOVER 1198 00:39:41,515 --> 00:39:43,718 AND RECOVERING MOTOR FUNCTION 1199 00:39:43,718 --> 00:39:44,619 FOLLOWING STROKE AND OTHERS ON 1200 00:39:44,619 --> 00:39:45,753 THE HORIZON. 1201 00:39:45,753 --> 00:39:47,588 MAJOR DRIVER BEHIND THESE RECENT 1202 00:39:47,588 --> 00:39:48,689 EVENTS HAS BEEN THE 1203 00:39:48,689 --> 00:39:51,158 IDENTIFICATION OF BRAIN ACTIVITY 1204 00:39:51,158 --> 00:39:52,259 BIOMARKERS THAT CAN BE USED TO 1205 00:39:52,259 --> 00:39:54,261 INFORM THE DESIGN OF 1206 00:39:54,261 --> 00:39:55,363 PERSONALIZED THERAPIES. 1207 00:39:55,363 --> 00:39:57,765 SO I'M SUMMARIZING A STUDY FROM 1208 00:39:57,765 --> 00:39:59,800 AN INTERDISCIPLINARY TEAM OF 1209 00:39:59,800 --> 00:40:02,069 NEUROSCIENTISTS AND ENGINEERS 1210 00:40:02,069 --> 00:40:04,772 AND CLINICIANS THAT MAKES A 1211 00:40:04,772 --> 00:40:07,808 SIGNIFICANT ADVANCE IN DBS 1212 00:40:07,808 --> 00:40:09,210 THERAPY IN PATIENTS WITH SEVERE 1213 00:40:09,210 --> 00:40:10,478 TREATMENT RESISTANT DEPRESSION. 1214 00:40:10,478 --> 00:40:12,580 THE TEAM APPROACH IS TO IDENTIFY 1215 00:40:12,580 --> 00:40:14,315 OBJECTIVE DATA DRIVEN BIOMARKERS 1216 00:40:14,315 --> 00:40:16,651 BASED ON LONG TERM MONITORING 1217 00:40:16,651 --> 00:40:19,487 BILE NOVEL IMPLANTED DBS AND 1218 00:40:19,487 --> 00:40:21,522 OVERALL THE STUDY SHOWS THE 1219 00:40:21,522 --> 00:40:22,490 POTENTIAL TO TRANSFORM 1220 00:40:22,490 --> 00:40:24,692 CLINICALLY GUIDED RECOVERY FOR A 1221 00:40:24,692 --> 00:40:26,127 VARIETY OF PSYCHIATRIC 1222 00:40:26,127 --> 00:40:26,594 CONDITIONS. 1223 00:40:26,594 --> 00:40:28,929 SO HERE THEY USE BIDIRECTIONAL 1224 00:40:28,929 --> 00:40:29,830 RECORDING AND STIMULATIONS 1225 00:40:29,830 --> 00:40:32,266 THROUGH THE DBS DEVICES. 1226 00:40:32,266 --> 00:40:35,302 IN THE SUB COLOSSAL CINGULATE IN 1227 00:40:35,302 --> 00:40:37,605 10 PATIENTS WITH TREATMENT 1228 00:40:37,605 --> 00:40:39,907 RESISTANT DEPRESSION. 1229 00:40:39,907 --> 00:40:42,209 EXPLAINABLE AI MODEL BASED ON 1230 00:40:42,209 --> 00:40:46,447 FIELD DATA REVEALED A SPECTRAL 1231 00:40:46,447 --> 00:40:47,014 DISSEMINATION, FOR CLINICAL 1232 00:40:47,014 --> 00:40:48,315 STATE. 1233 00:40:48,315 --> 00:40:50,518 SO WHETHER THE PATIENT OR 1234 00:40:50,518 --> 00:40:52,053 PARTICIPANT IS SICK OR STABLE 1235 00:40:52,053 --> 00:40:53,487 AND ALSO LOOKING AT THE 1236 00:40:53,487 --> 00:40:56,490 TRANSITION BETWEEN THESE TWO 1237 00:40:56,490 --> 00:40:56,724 STATES. 1238 00:40:56,724 --> 00:41:00,194 AND HERE YOU CAN SEE WHAT IT 1239 00:41:00,194 --> 00:41:01,395 TRACKS LIKE OVER TIME. 1240 00:41:01,395 --> 00:41:03,330 THIS IS A 24-WEEK STUDY. 1241 00:41:03,330 --> 00:41:07,101 ON THE TOP IS AN ASSESSMENT OF 1242 00:41:07,101 --> 00:41:08,502 THE PATIENT STATE USING 1243 00:41:08,502 --> 00:41:11,005 BEHAVIORAL MEASURES AND ON THE 1244 00:41:11,005 --> 00:41:15,342 BOTTOM IS THE DATA FROM THE 1245 00:41:15,342 --> 00:41:15,843 SPECTRAL DISCRIMINATIVE 1246 00:41:15,843 --> 00:41:16,310 COMPONENT. 1247 00:41:16,310 --> 00:41:18,612 SO YOU CAN SEE THEY MIRROR EACH 1248 00:41:18,612 --> 00:41:21,048 OTHER QUITE NICELY AND THESE 1249 00:41:21,048 --> 00:41:23,617 PATIENTS OVERTIME THROUGH THIS 1250 00:41:23,617 --> 00:41:26,020 DBS STIMULATION BY-AND-LARGE 1251 00:41:26,020 --> 00:41:27,121 MOVE FROM THE SICK STATE TO THE 1252 00:41:27,121 --> 00:41:27,955 STABLE STATE. 1253 00:41:27,955 --> 00:41:31,425 AND 9 OUT OF 10 PARTICIPANTS 1254 00:41:31,425 --> 00:41:33,027 RESPONDED WITH SEVEN GOING INTO 1255 00:41:33,027 --> 00:41:35,730 WHAT THEY WOULD CLASSIFY AS FULL 1256 00:41:35,730 --> 00:41:35,996 REMISSION. 1257 00:41:35,996 --> 00:41:40,468 NOW INTERESTINGLY, THIS IS -- IN 1258 00:41:40,468 --> 00:41:41,335 ONE PER DAYS PARTICIPANT THEY 1259 00:41:41,335 --> 00:41:42,837 COULD DETECT A RELAPSE FIVE 1260 00:41:42,837 --> 00:41:46,640 WEEKS BEFORE CLINICAL 1261 00:41:46,640 --> 00:41:46,974 MANIFESTATION. 1262 00:41:46,974 --> 00:41:51,812 THIS IS USING THE CSS TO MONITOR 1263 00:41:51,812 --> 00:41:52,646 THE STATE. 1264 00:41:52,646 --> 00:41:55,416 THIS DOTTED LINE HERE IS THE 1265 00:41:55,416 --> 00:41:56,350 THRESHOLD BETWEEN SICK AND 1266 00:41:56,350 --> 00:41:59,720 RESPONDING AND YOU CAN SEE HERE 1267 00:41:59,720 --> 00:42:02,456 THAT IN THE RED IS THE TRACKING 1268 00:42:02,456 --> 00:42:03,858 WITH THIS SPECTRAL 1269 00:42:03,858 --> 00:42:05,192 DISCRIMINATION COMPONENT AND YOU 1270 00:42:05,192 --> 00:42:07,194 CAN SEE ACROSS THE THRESHOLD AT 1271 00:42:07,194 --> 00:42:09,063 WEEK 12 WHEREAS BY THE 1272 00:42:09,063 --> 00:42:11,065 BEHAVIORAL MESSAGE THE PATIENT 1273 00:42:11,065 --> 00:42:12,399 DOESN'T CROSS THRESHOLD UNTIL 5 1274 00:42:12,399 --> 00:42:12,967 WEEKS LATER. 1275 00:42:12,967 --> 00:42:15,369 YOU CAN THINK ABOUT THIS AS A 1276 00:42:15,369 --> 00:42:18,239 WAY TO MONITOR THE PATIENT'S 1277 00:42:18,239 --> 00:42:20,141 RESPONSE STOT DBS THERAPY AND TO 1278 00:42:20,141 --> 00:42:21,742 BE ABLE TO ADJUST STIMULATION 1279 00:42:21,742 --> 00:42:24,178 BEFORE THE SYMPTOMS OCCUR. 1280 00:42:24,178 --> 00:42:26,781 AND GIVEN THESE MOOD STATES ARE 1281 00:42:26,781 --> 00:42:28,382 LONG TERM, THE POWERFUL THING 1282 00:42:28,382 --> 00:42:32,653 ABOUT THIS ANALYSIS IS IT IS 1283 00:42:32,653 --> 00:42:34,789 ROBUST TO MOMENT TO MOMENT 1284 00:42:34,789 --> 00:42:35,422 CHANGES WHETHER YOU'RE A LITTLE 1285 00:42:35,422 --> 00:42:37,191 BIT ANGRY, A LITTLE BIT HAPPY, 1286 00:42:37,191 --> 00:42:39,260 BUT TO THE OVERALL MOOD STATE OF 1287 00:42:39,260 --> 00:42:39,794 THE PATIENT. 1288 00:42:39,794 --> 00:42:43,197 NOW WHAT IS REALLY COOL AS WELL, 1289 00:42:43,197 --> 00:42:44,365 THEY DROPPED A CLASSIFIER BASED 1290 00:42:44,365 --> 00:42:46,467 ON FACIAL EXPRESSIONS THAT 1291 00:42:46,467 --> 00:42:48,569 CORRELATE WITH SDC AND SICK AND 1292 00:42:48,569 --> 00:42:49,570 STABLE TRANSITION TIME. 1293 00:42:49,570 --> 00:42:52,206 ONE CAN THINK ABOUT USING THESE 1294 00:42:52,206 --> 00:42:54,475 OBJECTIVE BIOMARKERS AND THE 1295 00:42:54,475 --> 00:42:56,477 MANAGEMENT OF PERSONALIZED DBS. 1296 00:42:56,477 --> 00:42:57,778 A BEAUTIFUL DEMONSTRATION OF 1297 00:42:57,778 --> 00:42:59,079 WHERE THE FIELD HAS COME AND 1298 00:42:59,079 --> 00:43:01,582 WHERE IT CAN GO IN THE FUTURE 1299 00:43:01,582 --> 00:43:03,784 GIVEN ALL THE INTEREST AND 1300 00:43:03,784 --> 00:43:04,985 RECENT SUCCESSES IN THIS FIELD 1301 00:43:04,985 --> 00:43:07,188 OF STUDY. 1302 00:43:07,188 --> 00:43:08,889 SO, JUST WANT TO HIGHLIGHT FOR 1303 00:43:08,889 --> 00:43:14,762 YOU A STUDY THAT WAS LED -- IT 1304 00:43:14,762 --> 00:43:17,198 WAS LED BY DR. LEE. 1305 00:43:17,198 --> 00:43:20,301 IT'S AN INTERNATIONAL 1306 00:43:20,301 --> 00:43:22,703 COLLABORATION WHERE THEY 1307 00:43:22,703 --> 00:43:24,471 DEVELOPED IMPROVED DOPAMINE 1308 00:43:24,471 --> 00:43:26,807 SENSORS BASED ON THESE SO-CALLED 1309 00:43:26,807 --> 00:43:31,478 GRAB SENSORS WHICH INVOLVE G 1310 00:43:31,478 --> 00:43:34,315 PROTEIN COUPLED RECEPTORS FOR 1311 00:43:34,315 --> 00:43:36,417 VARIOUS NEUROPEPTIDES COUPLED 1312 00:43:36,417 --> 00:43:40,788 WITH GFP THAT ALLOWS THE 1313 00:43:40,788 --> 00:43:42,590 DETECTION OF THE 1314 00:43:42,590 --> 00:43:43,257 NEUROTRANSMITTER OR NEUROPEPTIDE 1315 00:43:43,257 --> 00:43:44,191 OF INTEREST. 1316 00:43:44,191 --> 00:43:46,594 SO HERE THEY DEVELOPED IMPROVED 1317 00:43:46,594 --> 00:43:48,095 DOPAMINE SENSORS VERY 1318 00:43:48,095 --> 00:43:50,197 SIGNIFICANTLY IN BOTH THE RED 1319 00:43:50,197 --> 00:43:52,099 AND GREEN, WHICH GENERATES A LOT 1320 00:43:52,099 --> 00:43:54,802 OF FLEXIBILITY AND THIS ALLOWS 1321 00:43:54,802 --> 00:43:56,604 THEM TO PERFORM DUAL COLOR 1322 00:43:56,604 --> 00:43:56,904 IMAGING. 1323 00:43:56,904 --> 00:43:58,706 SO FOR EXAMPLE ONE CAN MONITOR 1324 00:43:58,706 --> 00:44:01,408 BOTH DOPAMINE RELEASE AS WELL AS 1325 00:44:01,408 --> 00:44:02,409 ACETYLCHOLINE RELEASE 1326 00:44:02,409 --> 00:44:04,511 SIMULTANEOUSLY IN A GIVEN BRAIN 1327 00:44:04,511 --> 00:44:04,812 REGION. 1328 00:44:04,812 --> 00:44:08,215 AND THESE GRAB SENSORS FOR 1329 00:44:08,215 --> 00:44:10,217 DOPAMINE ARE ALSO QUITE 1330 00:44:10,217 --> 00:44:12,186 SENSITIVE AND ALSO GIVE SOLVE 1331 00:44:12,186 --> 00:44:12,553 RESOLUTION. 1332 00:44:12,553 --> 00:44:14,321 SO VERY, VERY POWERFUL TOOLS 1333 00:44:14,321 --> 00:44:15,923 COMING FROM THE LEE LAB WITH 1334 00:44:15,923 --> 00:44:17,124 MANY COLLABORATORS 1335 00:44:17,124 --> 00:44:18,225 ACROSS-THE-BOARD, NOT JUST FOR 1336 00:44:18,225 --> 00:44:19,627 DOPAMINE BUT FOR MANY DIFFERENT 1337 00:44:19,627 --> 00:44:21,562 CONCEPT OF NEUROTRANSMITTERS AS 1338 00:44:21,562 --> 00:44:24,431 WELL AS NEUROPEPTIDES. 1339 00:44:24,431 --> 00:44:26,400 FINALLY I WANT TO HIGHLIGHT A 1340 00:44:26,400 --> 00:44:29,303 STUDY FROM ROB'S LAB AT NYU 1341 00:44:29,303 --> 00:44:32,706 FUNDED BY ONE OF OUR LARGE U19 1342 00:44:32,706 --> 00:44:33,007 PROJECTS. 1343 00:44:33,007 --> 00:44:38,479 AND HERE THE IDEA IS THAT WHILE 1344 00:44:38,479 --> 00:44:39,713 OAKSYITOSE IN DRIVES PATERNAL 1345 00:44:39,713 --> 00:44:42,383 CARE BEHAVIORS, SO WHEN A HUMOR 1346 00:44:42,383 --> 00:44:44,919 A MOUSE HEARS THEIR BABIES 1347 00:44:44,919 --> 00:44:47,855 CRYING, IT ELICITS CERTAIN 1348 00:44:47,855 --> 00:44:49,323 MATERNAL BEHAVIORS. 1349 00:44:49,323 --> 00:44:52,726 AND ALTHOUGH HUMAN OXYTOCIN HAS 1350 00:44:52,726 --> 00:44:53,727 BEEN KNOWN TO BE INVOLVED IN 1351 00:44:53,727 --> 00:44:55,229 THIS PROCESS AND RESPONSE, IN 1352 00:44:55,229 --> 00:44:57,231 THIS CASE OF THE MOUSE OF THE 1353 00:44:57,231 --> 00:44:59,633 CRYING SOUNDS OF THE MOUSE PUP, 1354 00:44:59,633 --> 00:45:04,271 THE CIRCUIT MECHANISMS OF THESE 1355 00:45:04,271 --> 00:45:04,872 LONG LASTING AND ROBUST 1356 00:45:04,872 --> 00:45:06,140 BEHAVIORS ARE STILL LARGELY 1357 00:45:06,140 --> 00:45:06,373 UNKNOWN. 1358 00:45:06,373 --> 00:45:10,844 SO HERE BY USING A TOUR DE FORCE 1359 00:45:10,844 --> 00:45:13,213 APPLICATION OF CHEMO GENETIC, 1360 00:45:13,213 --> 00:45:17,985 OPT GENETIC AND CIRCUITRY 1361 00:45:17,985 --> 00:45:19,887 BEHAVIORAL MEASURES, THEY TAGGED 1362 00:45:19,887 --> 00:45:22,356 THE OXYTOW SIN NEURONS IN THE 1363 00:45:22,356 --> 00:45:24,158 NUCLEUS AND SHOWED MINUTES LONG 1364 00:45:24,158 --> 00:45:25,693 RESPONSES OF CELLS USING CELL 1365 00:45:25,693 --> 00:45:27,761 ATTACHED AND PHOTO METRIC 1366 00:45:27,761 --> 00:45:31,031 REQUIREMENTS SHOWING THE 1367 00:45:31,031 --> 00:45:31,365 ATTACHED DATA. 1368 00:45:31,365 --> 00:45:34,435 AND THESE ARE LONG LASTING 1369 00:45:34,435 --> 00:45:34,668 CHANGES. 1370 00:45:34,668 --> 00:45:36,670 AND THEY ASKED THE QUESTION 1371 00:45:36,670 --> 00:45:39,440 ABOUT WHAT IS DRIVING THESE 1372 00:45:39,440 --> 00:45:41,942 RESPONSES, THESE AUDITORY 1373 00:45:41,942 --> 00:45:42,209 RESPONSES? 1374 00:45:42,209 --> 00:45:43,444 AND PURE TONES WOULDN'T DO IT 1375 00:45:43,444 --> 00:45:45,846 BUT THE RECORDED PUP CRIES 1376 00:45:45,846 --> 00:45:46,647 WOULD. 1377 00:45:46,647 --> 00:45:47,948 AND USING THIS THEY FOUND THAT 1378 00:45:47,948 --> 00:45:51,652 THERE IS A SPECIALIZED AUDITORY 1379 00:45:51,652 --> 00:45:54,955 PROJECTION FROM THE POSTERIOR 1380 00:45:54,955 --> 00:45:57,057 NUCLEUS OF THE THALAMUS THAT 1381 00:45:57,057 --> 00:46:00,461 GIVES A LONG LASTING OT NEURON 1382 00:46:00,461 --> 00:46:02,763 EXCITABILITY IN THE PARAVENTULAR 1383 00:46:02,763 --> 00:46:05,366 NUCLEUS AND THIS IS A VERY 1384 00:46:05,366 --> 00:46:07,067 INTERESTING DISINHIBITION THAT 1385 00:46:07,067 --> 00:46:09,169 GIVES RISE TO THE INCREASED 1386 00:46:09,169 --> 00:46:11,805 EXCITABILITY OF OXYTOCIN 1387 00:46:11,805 --> 00:46:12,072 NEURONS. 1388 00:46:12,072 --> 00:46:13,607 AND THE EFFECTIVENESS OF PUP 1389 00:46:13,607 --> 00:46:17,077 CALL APPROACH AND ISOLATED PUP 1390 00:46:17,077 --> 00:46:19,480 WAS IMPAIRED WHEN THE ACTIVATION 1391 00:46:19,480 --> 00:46:22,182 WAS CONDITIONALLY SUPPRESSED 1392 00:46:22,182 --> 00:46:32,559 USING CHEMO GENETIC APPROACHES. 1393 00:46:32,559 --> 00:46:34,795 SO, WITH THAT KIND OF RAPID TOUR 1394 00:46:34,795 --> 00:46:36,697 THROUGH WHAT IS GOING ON IN 1395 00:46:36,697 --> 00:46:37,798 BRAIN, JUST ENCOURAGE YOU TO 1396 00:46:37,798 --> 00:46:39,600 STAY UP-TO-DATE WITH WAWHAT WE 1397 00:46:39,600 --> 00:46:41,468 ARE DOING THROUGH THESE VARIOUS 1398 00:46:41,468 --> 00:46:41,769 CHANNELS. 1399 00:46:41,769 --> 00:46:44,071 WE HAVE A BRAIN BLOG. 1400 00:46:44,071 --> 00:46:46,707 I PROMISE YOU WON'T BE SPAMED 1401 00:46:46,707 --> 00:46:47,341 WITH TOO MANY, MAILS AND THE 1402 00:46:47,341 --> 00:46:48,609 REST OF THE INFORMATION IS TO 1403 00:46:48,609 --> 00:46:50,411 CONNECT WITH ONE OF OUR PROGRAM 1404 00:46:50,411 --> 00:46:51,912 OFFICERS AND ONE OF YOUR PROGRAM 1405 00:46:51,912 --> 00:46:54,381 OFFICERS TO FILL YOU IN ON THE 1406 00:46:54,381 --> 00:46:55,082 LATEST COMINGS AND GOINGS AND 1407 00:46:55,082 --> 00:46:57,584 HOW YOUR PROJECTS MIGHT BEST FIT 1408 00:46:57,584 --> 00:46:59,887 IN WITH WHAT WE'RE SUPPORTING, 1409 00:46:59,887 --> 00:47:00,587 THE BRAIN INITIATIVE. 1410 00:47:00,587 --> 00:47:03,390 AND YOU CAN FIND US HERE. 1411 00:47:03,390 --> 00:47:04,792 AND I WILL STOP HERE AND TAKE 1412 00:47:04,792 --> 00:47:15,035 ANY QUESTIONS. 1413 00:47:17,204 --> 00:47:18,705 >> THANK YOU FOR THE SUMMARY, 1414 00:47:18,705 --> 00:47:18,906 JOHN. 1415 00:47:18,906 --> 00:47:21,041 I WAS WONDERING, I JUST DON'T 1416 00:47:21,041 --> 00:47:21,542 REMEMBER WELL. 1417 00:47:21,542 --> 00:47:24,645 IN LOOKING AT THE BUDGET, THE 1418 00:47:24,645 --> 00:47:26,947 BUDGET SLIDE YOU PUT UP. 1419 00:47:26,947 --> 00:47:28,615 FOR FISCAL YEAR 2023, IT LOOKED 1420 00:47:28,615 --> 00:47:30,717 LIKE THE BASELINE IC 1421 00:47:30,717 --> 00:47:32,086 CONTRIBUTIONS WERE DRAMATICALLY 1422 00:47:32,086 --> 00:47:34,922 REDUCED OVER THE PREVIOUS YEARS. 1423 00:47:34,922 --> 00:47:36,323 AND I DON'T REMEMBER THAT BEING 1424 00:47:36,323 --> 00:47:37,391 ANTICIPATED BUT I COULD BE WRONG 1425 00:47:37,391 --> 00:47:38,225 ON THAT. 1426 00:47:38,225 --> 00:47:41,628 IS THAT SORT OF WHAT IS EXPECTED 1427 00:47:41,628 --> 00:47:42,596 IN THE 21ST CENTURY CURIOUS 1428 00:47:42,596 --> 00:47:45,933 WOULD MAKE UP THE DIFFERENCE? 1429 00:47:45,933 --> 00:47:48,035 >> GREAT QUESTION. 1430 00:47:48,035 --> 00:47:49,903 SO, WE HAVE A CERTAIN LEVEL OF 1431 00:47:49,903 --> 00:47:53,941 BASE FUNDING TO THE 10ICs AND 1432 00:47:53,941 --> 00:47:56,210 THE CURES FUNDS, THEY VARY FROM 1433 00:47:56,210 --> 00:47:58,412 YEAR TO YEAR BECAUSE THEY WERE 1434 00:47:58,412 --> 00:48:00,614 TAKING INTO ACCOUNT -- SO THE 1435 00:48:00,614 --> 00:48:02,116 CURES FUNDS WERE AUTHORIZED BUT 1436 00:48:02,116 --> 00:48:03,817 NOT APPROPRIATED. 1437 00:48:03,817 --> 00:48:04,718 APPROPRIATIONS HAPPEN YEAR TO 1438 00:48:04,718 --> 00:48:06,753 YEAR AND THEY FLUCTUATED UP AND 1439 00:48:06,753 --> 00:48:08,889 DOWN BASED ON WHAT WAS EXPECTED 1440 00:48:08,889 --> 00:48:10,624 FROM THE OVERALL FEDERAL BUDGET. 1441 00:48:10,624 --> 00:48:12,259 SO YOU'RE RIGHT. 1442 00:48:12,259 --> 00:48:13,527 WITH THE ANTICIPATION, WE WERE 1443 00:48:13,527 --> 00:48:16,029 GOING IT HAVE THIS INCREASE IN 1444 00:48:16,029 --> 00:48:18,432 2023 BECAUSE THE CURES ACT FUNDS 1445 00:48:18,432 --> 00:48:20,434 JUMPED FROM 1SOMETHING MILLION 1446 00:48:20,434 --> 00:48:23,804 TO 450 MILLION. 1447 00:48:23,804 --> 00:48:25,139 SO THAT KIND OF POSED AN 1448 00:48:25,139 --> 00:48:26,840 INTERESTING SET OF POTENTIAL 1449 00:48:26,840 --> 00:48:27,441 CIRCUMSTANCES. 1450 00:48:27,441 --> 00:48:28,942 ONE WAS WHAT ARE YOU GOING TO DO 1451 00:48:28,942 --> 00:48:30,043 WITH THIS MONEY? 1452 00:48:30,043 --> 00:48:31,245 THE CURIOUS ACT FUNDS ARE THAT 1453 00:48:31,245 --> 00:48:34,348 WE CAN CARRY THEM FORWARD. 1454 00:48:34,348 --> 00:48:36,183 BUT, IT KIND OF LOOKED FUNNY IF 1455 00:48:36,183 --> 00:48:38,018 WE'RE GOING TO HAVE NORTH OF 900 1456 00:48:38,018 --> 00:48:40,187 MILLION DOLLARS. 1457 00:48:40,187 --> 00:48:42,890 SO, THE WAY THAT THE 1458 00:48:42,890 --> 00:48:43,557 APPROPRIATORS HANDLE THIS, 1459 00:48:43,557 --> 00:48:44,825 LISTEN, THEY GAVE US A 60 1460 00:48:44,825 --> 00:48:46,160 MILLION DOLLAR INCREASE IN THE 1461 00:48:46,160 --> 00:48:47,461 TOP LINE BUDGET. 1462 00:48:47,461 --> 00:48:49,630 AND WHAT WE NEED TO WORRY ABOUT 1463 00:48:49,630 --> 00:48:50,964 IS OUR TOP LINE BUDGET. 1464 00:48:50,964 --> 00:48:53,667 HOW WE GET THERE IS SOMETHING 1465 00:48:53,667 --> 00:48:54,568 THAT OF COURSE WE'RE CONCERNED 1466 00:48:54,568 --> 00:48:55,636 WITH BUT THE IMPORTANT THING IS 1467 00:48:55,636 --> 00:48:57,237 HOW MUCH MONEY DO WE HAVE IN THE 1468 00:48:57,237 --> 00:48:57,471 BANK? 1469 00:48:57,471 --> 00:49:01,542 SO THAT WAS A WAY OF SMOOTHING 1470 00:49:01,542 --> 00:49:02,776 THIS OUT AND THEN THE GOAL RIGHT 1471 00:49:02,776 --> 00:49:06,246 NOW IS TO MAKE SURE WE MAINTAIN 1472 00:49:06,246 --> 00:49:07,948 THAT TOP LINE FUNDING. 1473 00:49:07,948 --> 00:49:10,751 SO THERE ARE A LOT OF -- MANY 1474 00:49:10,751 --> 00:49:12,052 UNSPOKEN ASSUMPTIONS THAT KIND 1475 00:49:12,052 --> 00:49:13,987 OF LED UP TO THIS. 1476 00:49:13,987 --> 00:49:17,090 THE GOOD NEWS IS THAT WHEN THE 1477 00:49:17,090 --> 00:49:18,058 CURES FUNDS HAD DROPPED IN 1478 00:49:18,058 --> 00:49:19,793 PREVIOUS YEARS, THEY MADE UP FOR 1479 00:49:19,793 --> 00:49:24,798 IT IN THE BASE APPROPRIATIONS 1480 00:49:24,798 --> 00:49:25,499 AND IT'S KNEW TO THE REALLY 1481 00:49:25,499 --> 00:49:28,769 GREAT WORK THAT OUR FUNDED DOES 1482 00:49:28,769 --> 00:49:31,171 THAT WE USE THIS TO ADVOCATE FOR 1483 00:49:31,171 --> 00:49:33,540 SUSTAINED HIGH-LEVEL FUNDING. 1484 00:49:33,540 --> 00:49:36,276 BUT APPROPRIATIONS ARE MADE YEAR 1485 00:49:36,276 --> 00:49:36,877 TO YEAR. 1486 00:49:36,877 --> 00:49:39,379 WE COULD ONLY RESPOND TO THE 1487 00:49:39,379 --> 00:49:40,380 APPROPRIATORS WHEN THEY ASK US 1488 00:49:40,380 --> 00:49:42,282 WHAT OUR NEEDS ARE AND WE REALLY 1489 00:49:42,282 --> 00:49:43,584 HAVE DONE ALL THAT WE CAN TO 1490 00:49:43,584 --> 00:49:45,385 SHOW THEM THE GREAT IMPACT THE 1491 00:49:45,385 --> 00:49:46,687 BRAIN HAS HAD AND WILL HAVE ON 1492 00:49:46,687 --> 00:49:49,089 THE FIELD AND THIS IS ABOUT 1493 00:49:49,089 --> 00:49:49,790 WHERE WE ARE. 1494 00:49:49,790 --> 00:49:51,592 IT'S A YEAR TO YEAR THING AND WE 1495 00:49:51,592 --> 00:49:53,594 ARE REALLY WORKING HARD TO MAKE 1496 00:49:53,594 --> 00:49:55,696 SURE THAT THEY APPRECIATE THE 1497 00:49:55,696 --> 00:49:58,899 VALUE THAT BRAIN BRINGS TO THE 1498 00:49:58,899 --> 00:49:59,967 ENTERPRISE. 1499 00:49:59,967 --> 00:50:00,634 TED? 1500 00:50:00,634 --> 00:50:02,202 >> HI, JOHN. 1501 00:50:02,202 --> 00:50:03,804 THANKS FOR A TERRIFIC SUMMARY 1502 00:50:03,804 --> 00:50:05,505 AND FOR THE IMPACT THAT YOU HAVE 1503 00:50:05,505 --> 00:50:07,774 HAD AND THE TEAM AND ALL THE 1504 00:50:07,774 --> 00:50:08,208 AMAZING RESEARCH. 1505 00:50:08,208 --> 00:50:10,077 IT'S REALLY TERRIFIC TO SEE. 1506 00:50:10,077 --> 00:50:11,678 MY QUESTION -- I WAS RUNNING 1507 00:50:11,678 --> 00:50:13,380 LATE SO I'M SORRY, MAYBE YOU 1508 00:50:13,380 --> 00:50:13,981 COVERED THIS. 1509 00:50:13,981 --> 00:50:15,882 MY QUESTION IS ABOUT TRAINING. 1510 00:50:15,882 --> 00:50:20,087 AND IT HAS TO DO WITH RELEASE IN 1511 00:50:20,087 --> 00:50:22,856 DECEMBER FROM AN ADVISORY 1512 00:50:22,856 --> 00:50:24,224 COMMITTEE TO THE DIRECTOR, A 1513 00:50:24,224 --> 00:50:27,527 WORKING GROUP ON POSTDOCTORAL 1514 00:50:27,527 --> 00:50:27,794 FELLOWS. 1515 00:50:27,794 --> 00:50:29,896 ONE OF THE -- WHAT MAKES ALL OF 1516 00:50:29,896 --> 00:50:30,897 THESE PAPERS IN NATURE AND 1517 00:50:30,897 --> 00:50:32,899 SCIENCE POSSIBLE BESIDES THE 1518 00:50:32,899 --> 00:50:35,102 EXTRAORDINARY FUNDING IS THE 1519 00:50:35,102 --> 00:50:35,902 EXTRAORDINARY PEOPLE THAT WE 1520 00:50:35,902 --> 00:50:37,804 EACH HAVE IN OUR LABS. 1521 00:50:37,804 --> 00:50:40,907 AND IT REALLY IS BECOMING AN 1522 00:50:40,907 --> 00:50:42,509 INCREASINGLY DIFFICULT AND 1523 00:50:42,509 --> 00:50:44,611 CHALLENGING TIME FOR OUR 1524 00:50:44,611 --> 00:50:45,045 TRAINEES. 1525 00:50:45,045 --> 00:50:46,780 AND I JUST WONDERED IF THERE 1526 00:50:46,780 --> 00:50:47,981 WERE THOUGHTS. 1527 00:50:47,981 --> 00:50:49,416 ONE NICE THING THE BRAIN 1528 00:50:49,416 --> 00:50:52,119 INITIATIVE HAS IS THE ABILITY TO 1529 00:50:52,119 --> 00:50:54,021 BE MORE NIMBLE THAN INSTITUTES. 1530 00:50:54,021 --> 00:50:56,657 SOMETHING THEY HAVE SHOWN IN 1531 00:50:56,657 --> 00:50:59,026 THE, FOR EXAMPLE, THE PLANS FOR 1532 00:50:59,026 --> 00:51:00,027 ENHANCING DIVERSE PERSPECTIVES 1533 00:51:00,027 --> 00:51:00,427 IN RESEARCH. 1534 00:51:00,427 --> 00:51:03,297 IT SEEMS LIKE THE BRAIN 1535 00:51:03,297 --> 00:51:04,331 INITIATIVE MIGHT BE PARTICULARLY 1536 00:51:04,331 --> 00:51:07,134 POISED TO HELP MAKE A DIFFERENCE 1537 00:51:07,134 --> 00:51:09,336 ON HOW WE TRAIN THE NEXT 1538 00:51:09,336 --> 00:51:10,737 GENERATION OF OUR BRAIN 1539 00:51:10,737 --> 00:51:11,605 RESEARCHERS. 1540 00:51:11,605 --> 00:51:13,240 AND SO I WONDER -- I REALIZE 1541 00:51:13,240 --> 00:51:15,442 THIS JUST CAME OUT 6 OR 8 WEEKS 1542 00:51:15,442 --> 00:51:16,943 AGO, BUT I WONDER WHAT THE 1543 00:51:16,943 --> 00:51:18,312 THOUGHTS ARE, IF THERE ARE ANY 1544 00:51:18,312 --> 00:51:20,814 IN RESPONSE TO THAT, AND THE 1545 00:51:20,814 --> 00:51:22,416 PARTICULAR CONCERNS ABOUT OUR 1546 00:51:22,416 --> 00:51:26,019 COMMUNITY OF POSTDOCTORAL 1547 00:51:26,019 --> 00:51:26,320 RESEARCHERS. 1548 00:51:26,320 --> 00:51:28,255 >> IT'S AN ONGOING CONCERN. 1549 00:51:28,255 --> 00:51:30,324 AS I'M SITTING HERE AS DIRECTOR 1550 00:51:30,324 --> 00:51:32,125 OF THE BRAIN INITIATIVE BUT ALSO 1551 00:51:32,125 --> 00:51:34,328 AS SOMEBODY WHO STILL HAS A LAB 1552 00:51:34,328 --> 00:51:36,630 WITH TRAINEES IN IT. 1553 00:51:36,630 --> 00:51:43,003 IT'S A BIG CONCERN. 1554 00:51:43,003 --> 00:51:46,039 MY VIEW IS THE LANDSCAPE IS 1555 00:51:46,039 --> 00:51:46,340 CHANGING. 1556 00:51:46,340 --> 00:51:50,310 THE DEMANDS THAT OUR TRAINEES 1557 00:51:50,310 --> 00:51:52,546 ARE UNDER AND THEIR PROFESSIONAL 1558 00:51:52,546 --> 00:51:54,247 OPPORTUNITIES AND HOW THE 1559 00:51:54,247 --> 00:51:55,749 TRAINING CAN HELP THEM ACHIEVE 1560 00:51:55,749 --> 00:51:58,819 THEIR GOALS, WHETHER IT'S AN 1561 00:51:58,819 --> 00:52:00,454 ACADEMIC POSITIONS OR INDUSTRY 1562 00:52:00,454 --> 00:52:03,623 OR OTHER WALKS OF LIFE, THE 1563 00:52:03,623 --> 00:52:04,825 REQUIREMENTS TO GET THEM TO 1564 00:52:04,825 --> 00:52:06,126 THESE DIFFERENT PLACES HAS 1565 00:52:06,126 --> 00:52:06,360 CHANGED. 1566 00:52:06,360 --> 00:52:09,763 AND THE REALITY IS THAT 1567 00:52:09,763 --> 00:52:11,031 POSTDOCTORAL TRAINING ISN'T 1568 00:52:11,031 --> 00:52:12,833 STRICTLY NECESSARY TO BE 1569 00:52:12,833 --> 00:52:14,234 SUCCESSFUL IN DIFFERENT WALKS OF 1570 00:52:14,234 --> 00:52:15,535 SCIENTIFIC LIFE. 1571 00:52:15,535 --> 00:52:18,472 AND OF COURSE THIS POSES ISSUES 1572 00:52:18,472 --> 00:52:20,140 IN TERMS OF, NOT JUST IN 1573 00:52:20,140 --> 00:52:21,241 TRAINING BUT IN TERMS OF WHO 1574 00:52:21,241 --> 00:52:22,442 WILL DO THE WORK. 1575 00:52:22,442 --> 00:52:24,444 I THINK WE JUST NEED TO FIGURE 1576 00:52:24,444 --> 00:52:26,546 OUT HOW NIH AND HOW THE 1577 00:52:26,546 --> 00:52:28,248 SCIENTIFIC COMMUNITY IS GOING TO 1578 00:52:28,248 --> 00:52:29,916 DEAL WITH THE URGENT NEED TO 1579 00:52:29,916 --> 00:52:31,551 ADDRESS THESE ISSUES. 1580 00:52:31,551 --> 00:52:33,320 BRAIN INITIATIVE IS JUST A VERY 1581 00:52:33,320 --> 00:52:35,155 SMALL PART OF NIH. 1582 00:52:35,155 --> 00:52:36,456 BUT WE ARE DEFINITELY TRYING TO 1583 00:52:36,456 --> 00:52:38,358 PUSH THE ENVELOPE WHERE WE CAN. 1584 00:52:38,358 --> 00:52:40,060 THE PDP IS ONE AREA. 1585 00:52:40,060 --> 00:52:42,763 OUR K99 AS A DIVERSITY FOCUSED 1586 00:52:42,763 --> 00:52:44,297 MECHANISM, WE EXPANDED THE 1587 00:52:44,297 --> 00:52:45,565 ELIGIBILITY BY A YEAR, WHICH I 1588 00:52:45,565 --> 00:52:48,668 THINK HAS BEEN A HUGE HELP. 1589 00:52:48,668 --> 00:52:50,904 IN TERMS OF THE PAY SCALES, WE 1590 00:52:50,904 --> 00:52:53,707 HAVE TO GO BY WHAT THE PAY 1591 00:52:53,707 --> 00:52:55,509 SCALES INSTITUTED BY THE NIH AS 1592 00:52:55,509 --> 00:52:56,610 WELL AS BY THE INSTITUTIONS. 1593 00:52:56,610 --> 00:52:58,178 SO IT'S GOING TO TAKE A WHOLE 1594 00:52:58,178 --> 00:52:59,579 COMMUNITY TOW ADDRESS THIS. 1595 00:52:59,579 --> 00:53:03,984 NIH CAN ONLY DO A PARTNERSHIP 1596 00:53:03,984 --> 00:53:05,085 WITH THE INSTITUTIONS. 1597 00:53:05,085 --> 00:53:06,987 WE CANNOT ASK CONGRESS FOR MORE 1598 00:53:06,987 --> 00:53:07,187 MONEY. 1599 00:53:07,187 --> 00:53:08,989 IF WE WANT OUR POSTDOCS TO BE 1600 00:53:08,989 --> 00:53:10,357 PAID MORE, IT'S GOING TO BE UP 1601 00:53:10,357 --> 00:53:13,894 TO THE COMMUNITY TO ADVOCATE FOR 1602 00:53:13,894 --> 00:53:15,195 THEMSELVES AND FOR US TO TRY TO 1603 00:53:15,195 --> 00:53:17,063 GET MORE FUNDING. 1604 00:53:17,063 --> 00:53:18,899 I MEAN, I DON'T LIKE TO THINK IN 1605 00:53:18,899 --> 00:53:21,501 A ZERO SUM SCENARIO, BUT IT'S A 1606 00:53:21,501 --> 00:53:22,569 ZERO SUM GAIN RIGHT NOW. 1607 00:53:22,569 --> 00:53:24,604 CONGRESS ALLOCATES SO MUCH MONEY 1608 00:53:24,604 --> 00:53:27,908 TO THE NIH TO SUPPORT BIOMEDICAL 1609 00:53:27,908 --> 00:53:31,077 RESEARCH AND IF WE INCREASE THE 1610 00:53:31,077 --> 00:53:32,512 PAY TO THE FOLKS DOING THE WORK, 1611 00:53:32,512 --> 00:53:33,780 IT'S GOT TO COME FROM SOMEWHERE. 1612 00:53:33,780 --> 00:53:37,584 AND THE THIS IS JUST AERALITIY. 1613 00:53:37,584 --> 00:53:39,386 I'M DEDICATED TO MAKING THIS A 1614 00:53:39,386 --> 00:53:40,887 BETTER WORKPLACE ENVIRONMENT FOR 1615 00:53:40,887 --> 00:53:42,389 EVERYBODY, ESPECIALLY OUR 1616 00:53:42,389 --> 00:53:42,656 TRAINEES. 1617 00:53:42,656 --> 00:53:44,391 WE DON'T WANT TO LOSE THE TALENT 1618 00:53:44,391 --> 00:53:44,591 HERE. 1619 00:53:44,591 --> 00:53:46,460 BUT IT'S GOING TO TAKE EFFORT ON 1620 00:53:46,460 --> 00:53:48,395 EVERYBODY'S BEHALF TO ADVOCATE 1621 00:53:48,395 --> 00:53:51,198 TO GET THESE CHANGES INTO PLACE. 1622 00:53:51,198 --> 00:53:52,532 >> THERE ARE A NUMBER -- 1623 00:53:52,532 --> 00:53:53,800 OBVIOUSLY THE FINANCIAL ISSUES 1624 00:53:53,800 --> 00:53:54,901 ARE ONE THING THAT'S MENTIONED 1625 00:53:54,901 --> 00:53:56,203 IN TERMS OF SALARY SUPPORT. 1626 00:53:56,203 --> 00:53:57,904 BUT THE OTHER PART OF THAT 1627 00:53:57,904 --> 00:54:00,407 REPORT ARE THINGS TO HELP 1628 00:54:00,407 --> 00:54:02,108 SUPPORT THEIR COMMUNITY AND 1629 00:54:02,108 --> 00:54:02,776 IDENTITY AND GROWTH. 1630 00:54:02,776 --> 00:54:05,011 AND THAT'S SOMETHING THAT MIGHT 1631 00:54:05,011 --> 00:54:07,914 BE A PLACE ONE COULD THINK ABOUT 1632 00:54:07,914 --> 00:54:11,117 THE WAY ADDING FOCUS ON DIVERSE 1633 00:54:11,117 --> 00:54:12,886 PERSPECTIVES WAS ADDED. 1634 00:54:12,886 --> 00:54:13,787 INCREASING THAT IF THEY ARE 1635 00:54:13,787 --> 00:54:14,488 INCLUDED IN GRANTS AND THINGS 1636 00:54:14,488 --> 00:54:15,088 LIKE THAT. 1637 00:54:15,088 --> 00:54:16,690 THERE ARE WAYS IN THE REPORT 1638 00:54:16,690 --> 00:54:17,991 THAT COULD HELP MAKE A 1639 00:54:17,991 --> 00:54:20,193 DIFFERENCE TO THE COMMUNITY OF 1640 00:54:20,193 --> 00:54:21,695 POSTDOCTORAL FELLOWS THAT MAY 1641 00:54:21,695 --> 00:54:24,998 NOT BE FINANCIALLY COSTLY BUT 1642 00:54:24,998 --> 00:54:26,700 ADMINISTRATIVELY CHALLENGING. 1643 00:54:26,700 --> 00:54:27,200 >> RIGHT. 1644 00:54:27,200 --> 00:54:30,737 AND WE'RE SEEING THESE THINGS, 1645 00:54:30,737 --> 00:54:32,005 THESE ISSUES, ADDRESSED IN THE 1646 00:54:32,005 --> 00:54:34,975 PDP COMING OUT AND PEOPLE TAKING 1647 00:54:34,975 --> 00:54:35,509 ACTION. 1648 00:54:35,509 --> 00:54:37,611 SO WE ARE HOPING BY FOCUSING 1649 00:54:37,611 --> 00:54:39,613 PEOPLE'S ATTENTION ON THIS THAT 1650 00:54:39,613 --> 00:54:40,747 ITSELF WILL HELP MAKE A 1651 00:54:40,747 --> 00:54:41,715 DIFFERENCE AS WELL. 1652 00:54:41,715 --> 00:54:45,385 WE HAVE SEEN MORE THAN A FEW 1653 00:54:45,385 --> 00:54:48,522 FOLKS WHO STARTED OUT AS 1654 00:54:48,522 --> 00:54:50,891 POSTDOCS OR JUNIOR FACULTY ON 1655 00:54:50,891 --> 00:54:51,725 BRAIN-FUNNELEDDED GRANTS WHO ARE 1656 00:54:51,725 --> 00:54:53,693 NOW PIs ON THESE GRANTS. 1657 00:54:53,693 --> 00:54:55,228 WE JUST HAVE TO DO IT A PERSON 1658 00:54:55,228 --> 00:54:57,097 AT A TIME BUT IT'S REALLY GOING 1659 00:54:57,097 --> 00:54:58,665 TO TAKE A CONCERTED EFFORT ON 1660 00:54:58,665 --> 00:55:03,937 THE ALL OF OUR PARTS. 1661 00:55:03,937 --> 00:55:06,706 DAVID? 1662 00:55:06,706 --> 00:55:08,441 >> HI, JOHN. 1663 00:55:08,441 --> 00:55:08,842 QUICK COMMENT ON. 1664 00:55:08,842 --> 00:55:10,510 TOUR DE FORCE IS ALWAYS REALLY 1665 00:55:10,510 --> 00:55:11,211 SETTING SIGHTS. 1666 00:55:11,211 --> 00:55:13,046 I WONDER HOW YOU VIEW BRAIN'S 1667 00:55:13,046 --> 00:55:14,948 ROLE IN DISSEMINATING THIS 1668 00:55:14,948 --> 00:55:17,918 FURTHER DOWN THE TRAINEE 1669 00:55:17,918 --> 00:55:19,519 SPECTRUM AND TO UNDERGRADS. 1670 00:55:19,519 --> 00:55:21,021 ARE THESE THINGS THAT YOU 1671 00:55:21,021 --> 00:55:22,822 MENTIONED, A LIVING TEXTBOOK IN 1672 00:55:22,822 --> 00:55:23,356 THE FUTURE? 1673 00:55:23,356 --> 00:55:28,361 HOW DO WE GET ALL THESE GREAT 1674 00:55:28,361 --> 00:55:31,331 ADVANCES TO OUR TRAINEES? 1675 00:55:31,331 --> 00:55:36,102 >> SO, AS I MENTIONED -- WE 1676 00:55:36,102 --> 00:55:36,636 SIGNED ON TO THE BLUEPRINT 1677 00:55:36,636 --> 00:55:38,071 ENDURE PROGRAM, WHICH IS 1678 00:55:38,071 --> 00:55:41,241 PROVIDING R25 INSTITUTIONAL 1679 00:55:41,241 --> 00:55:43,243 GRANTS TO BRAIN UNDERGRADS AND 1680 00:55:43,243 --> 00:55:44,244 FROM DIFFERENT BACKGROUNDS. 1681 00:55:44,244 --> 00:55:47,247 SO THAT IS KIND OF ADDRESSING 1682 00:55:47,247 --> 00:55:49,049 THE ISSUE EARLIER IN THE 1683 00:55:49,049 --> 00:55:50,116 SO-CALLED PIPELINE. 1684 00:55:50,116 --> 00:55:52,118 BUT IT'S NOT REALLY JUST ABOUT 1685 00:55:52,118 --> 00:55:53,186 DEVELOPING THE PIPELINE. 1686 00:55:53,186 --> 00:55:56,256 IT'S A MATTER OF BRINGING FOLKS 1687 00:55:56,256 --> 00:55:59,292 IN AND KEEPING THEM IN AND 1688 00:55:59,292 --> 00:56:00,560 HELPING THEM PROGRESS ALONG THE 1689 00:56:00,560 --> 00:56:01,161 CAREER PATH. 1690 00:56:01,161 --> 00:56:02,662 SO WE'RE LOOKING AT EVERY STAGE 1691 00:56:02,662 --> 00:56:05,865 THAT WE CAN RIGHT NOW AND IT'S A 1692 00:56:05,865 --> 00:56:07,834 LONG TERM INVESTMENT. 1693 00:56:07,834 --> 00:56:09,836 IT WILL TAKE -- DECADES BEFORE 1694 00:56:09,836 --> 00:56:11,871 YOU SEE SOMEBODY RISE TO A LEVEL 1695 00:56:11,871 --> 00:56:13,540 OF LEADERSHIP STARTING OUT VERY, 1696 00:56:13,540 --> 00:56:16,076 VERY EARLY. 1697 00:56:16,076 --> 00:56:18,378 AND WE'RE TRYING TO PUSH ON ALL 1698 00:56:18,378 --> 00:56:19,479 AREAS WE CAN. 1699 00:56:19,479 --> 00:56:21,448 AND I THINK AS WE HAVE SEEN IN 1700 00:56:21,448 --> 00:56:25,452 OUR K99 PROGRAM, WE SEEN MANY OF 1701 00:56:25,452 --> 00:56:26,753 THESE K99ERS AS WE REFER TO 1702 00:56:26,753 --> 00:56:28,955 THEM, TRANSITION TO REALLY NICE 1703 00:56:28,955 --> 00:56:30,190 FACULTY JOBS ACROSS THE COUNTRY 1704 00:56:30,190 --> 00:56:32,292 AND WE'RE STARTING TO SEE 1705 00:56:32,292 --> 00:56:33,693 APPLICATIONS COME IN, WE'RE 1706 00:56:33,693 --> 00:56:35,195 FUNDING SOME OF THOSE FOLKS NOW 1707 00:56:35,195 --> 00:56:39,065 AND WE'RE ALSO SEEING DIVERSITY 1708 00:56:39,065 --> 00:56:39,899 SUPPLEMENTS FROM THESE FOLKS 1709 00:56:39,899 --> 00:56:42,736 COMING IN. 1710 00:56:42,736 --> 00:56:45,705 SO IT'S JUST TRYING TO PUT 1711 00:56:45,705 --> 00:56:48,708 PRESSURE AND PRESS ON ALL THE 1712 00:56:48,708 --> 00:56:51,011 LEVERS WE CAN TO GENERATE A MORE 1713 00:56:51,011 --> 00:56:52,178 ROBUST AND THE DIVERSE FOOTPRINT 1714 00:56:52,178 --> 00:56:53,713 WHICH IS WHAT WE NEED TO SOLVE 1715 00:56:53,713 --> 00:56:57,217 THE PROBLEMS WE ARE FACING, 1716 00:56:57,217 --> 00:57:07,494 SCIENTIFICALLY. 1717 00:57:09,829 --> 00:57:11,698 OKAY, ANY OTHER QUESTIONS? 1718 00:57:11,698 --> 00:57:13,400 SUSAN, HOW ARE WE ON TIME? 1719 00:57:13,400 --> 00:57:14,034 >> WE'RE GREAT. 1720 00:57:14,034 --> 00:57:21,207 WE ARE RIGHT ON TIME. 1721 00:57:21,207 --> 00:57:21,641 >> OKAY. 1722 00:57:21,641 --> 00:57:22,308 HAPPY TO ENTERTAIN OTHER 1723 00:57:22,308 --> 00:57:24,110 QUESTIONS IN THE CHAT OR AS THEY 1724 00:57:24,110 --> 00:57:25,211 COME UP IN DISCUSSION. 1725 00:57:25,211 --> 00:57:27,013 THANK YOU ALL FOR YOUR ATTENTION 1726 00:57:27,013 --> 00:57:28,515 AND YOUR SUPPORT. 1727 00:57:28,515 --> 00:57:32,419 >> SO NEXT WE WILL HEAR FROM 1728 00:57:32,419 --> 00:57:33,953 DR. ALYSSA PICCHINI SCHAFFER, 1729 00:57:33,953 --> 00:57:36,222 THE VICE PRESIDENT AND SENIOR 1730 00:57:36,222 --> 00:57:37,323 SCIENTIST OF THE SIMONS 1731 00:57:37,323 --> 00:57:37,624 FOUNDATION. 1732 00:57:37,624 --> 00:57:38,525 JOHN INTRODUCED HER A FEW 1733 00:57:38,525 --> 00:57:39,626 MINUTES AGO. 1734 00:57:39,626 --> 00:57:41,594 HOPEFULLY ALL IS WELL WITH YOUR 1735 00:57:41,594 --> 00:57:43,530 INTERNET AND WE LOOK FORWARD TO 1736 00:57:43,530 --> 00:57:45,432 HEARING YOUR PRESENTATION. 1737 00:57:45,432 --> 00:57:47,534 >> I HOPE SO. 1738 00:57:47,534 --> 00:57:49,803 HELLO, CAN EVERYONE HEAR ME? 1739 00:57:49,803 --> 00:57:50,070 >> YES. 1740 00:57:50,070 --> 00:57:53,506 YOU HAVE YELLOW BARS SO -- 1741 00:57:53,506 --> 00:57:55,442 >> GREAT, I WANTED TO SAY HELLO 1742 00:57:55,442 --> 00:57:56,609 WHILE MY VIDEO IS ON. 1743 00:57:56,609 --> 00:57:58,011 WE ARE IN THE MIDDLE OF A 1744 00:57:58,011 --> 00:57:59,145 SNOWSTORM IN NEW YORK CITY WHICH 1745 00:57:59,145 --> 00:58:01,081 IS MAKING MY INTERNET A LITTLE 1746 00:58:01,081 --> 00:58:01,648 BIT UNSTABLE. 1747 00:58:01,648 --> 00:58:04,918 SO I AM GOING TO TURN MY VIDEO 1748 00:58:04,918 --> 00:58:06,519 OFF AS SOON AS I CAN FIGURE 1749 00:58:06,519 --> 00:58:07,921 OUT -- I THINK I HAVE TO STOP 1750 00:58:07,921 --> 00:58:10,657 SHARING TO DO THAT FIRST. 1751 00:58:10,657 --> 00:58:11,524 SO YOU'LL JUST HEAR MY VOICE BUT 1752 00:58:11,524 --> 00:58:12,659 I'M GLAD TO BE ABLE TO PRESENT 1753 00:58:12,659 --> 00:58:17,397 TO YOU TODAY. 1754 00:58:17,397 --> 00:58:20,567 >> WE LOST YOUR VIDEO -- YOUR 1755 00:58:20,567 --> 00:58:21,234 SLIDES. 1756 00:58:21,234 --> 00:58:21,634 >> OKAY. 1757 00:58:21,634 --> 00:58:22,001 GREAT. 1758 00:58:22,001 --> 00:58:23,870 CAN YOU SEE MY SLIDES NOW? 1759 00:58:23,870 --> 00:58:24,437 >> YES. 1760 00:58:24,437 --> 00:58:24,804 >> WONDERFUL. 1761 00:58:24,804 --> 00:58:26,439 SO THANKS AGAIN FOR HAVING ME. 1762 00:58:26,439 --> 00:58:28,742 MY NAME IS ALYSSA PICCHINI 1763 00:58:28,742 --> 00:58:30,443 SCHAFFER AND I'M A 1764 00:58:30,443 --> 00:58:31,544 VICE PRESIDENT AND SENIOR 1765 00:58:31,544 --> 00:58:34,647 SCIENTIST FOR THE NEUROSCIENCE 1766 00:58:34,647 --> 00:58:35,215 COLLABORATIONS AT THE SIMONS 1767 00:58:35,215 --> 00:58:35,515 FOUNDATION. 1768 00:58:35,515 --> 00:58:37,117 AND TODAY I'M GOING TO GIVE YOU 1769 00:58:37,117 --> 00:58:39,152 UPDATES FROM ACROSS DIFFERENT 1770 00:58:39,152 --> 00:58:40,553 DIVISIONS ACROSS ALL OF THE 1771 00:58:40,553 --> 00:58:42,355 NEUROSCIENCE WE HAVE GOING ON. 1772 00:58:42,355 --> 00:58:44,657 THIS INCLUDES OUR AUTISM IN 1773 00:58:44,657 --> 00:58:45,592 NEUROSCIENCE DIVISION, OUR 1774 00:58:45,592 --> 00:58:47,761 CENTER FOR COMPUTATIONAL IN 1775 00:58:47,761 --> 00:58:50,530 NEUROSCIENCE AND A NEW 1776 00:58:50,530 --> 00:58:51,331 EDITORIALLY INDEPENDENT 1777 00:58:51,331 --> 00:58:53,833 PUBLICATION CALLED THE 1778 00:58:53,833 --> 00:58:55,935 TRANSMITTER. 1779 00:58:55,935 --> 00:58:58,471 FIRST I WANT TO STEP BACK AND 1780 00:58:58,471 --> 00:58:59,639 LETTED YOU KNOW WHAT THE SIMONS 1781 00:58:59,639 --> 00:59:02,008 FOUNDATION IS. 1782 00:59:02,008 --> 00:59:04,477 THE SIMONS FOUNDATION IS A 1783 00:59:04,477 --> 00:59:05,545 PHILANTHROPIC ORGANIZATION 1784 00:59:05,545 --> 00:59:07,580 DEDICATED TO ADVANCING THE 1785 00:59:07,580 --> 00:59:08,114 FRONTIERS OF BASIC SCIENCE 1786 00:59:08,114 --> 00:59:09,849 THROUGH GRANT MAKING, IN-HOUSE 1787 00:59:09,849 --> 00:59:11,885 RESEARCH AND PUBLIC ENGAGEMENT. 1788 00:59:11,885 --> 00:59:15,255 SINCE ITS FOUNDING IN 1994 BITE 1789 00:59:15,255 --> 00:59:17,157 JIM AND MARILYN SIMONS, THE 1790 00:59:17,157 --> 00:59:18,792 FOUNDATION HAS BEEN A CHAMPION 1791 00:59:18,792 --> 00:59:19,559 OF BASIC SCIENCE. 1792 00:59:19,559 --> 00:59:21,161 WE BELIEVE IN ASKING BIG 1793 00:59:21,161 --> 00:59:23,163 QUESTIONS AND PROVIDING 1794 00:59:23,163 --> 00:59:25,098 SUSTAINED SUPPORT TO RESEARCHERS 1795 00:59:25,098 --> 00:59:26,499 WORKING TO UNRAVEL ALL THE 1796 00:59:26,499 --> 00:59:31,104 MYSTERIES OF THE UNIVERSE. 1797 00:59:31,104 --> 00:59:32,472 THE SIMONS FOUNDATION MAKES 1798 00:59:32,472 --> 00:59:34,741 GRANTS IN FOUR SCIENTIFIC AREAS, 1799 00:59:34,741 --> 00:59:36,576 AUTISM IN NEUROSCIENCE, 1800 00:59:36,576 --> 00:59:40,380 MATHEMATICS AND THE PHYSICAL 1801 00:59:40,380 --> 00:59:40,947 SCIENCES, LIFE SCIENCES AND 1802 00:59:40,947 --> 00:59:42,749 SCIENCE SOCIETY AND CULTURE. 1803 00:59:42,749 --> 00:59:44,951 ADDITIONALLY, WE HAVE AN 1804 00:59:44,951 --> 00:59:47,287 IN-HOUSE RESEARCH INSTITUTE. 1805 00:59:47,287 --> 00:59:48,655 OUR FLATIRON INSTITUTE OPENED IN 1806 00:59:48,655 --> 00:59:52,759 2016 AND CONDUCTS COMPUTATIONAL 1807 00:59:52,759 --> 00:59:56,062 RESEARCH: AND THROUGH OUR WORK, 1808 00:59:56,062 --> 00:59:59,265 OUR GOAL IS REALLY TO MAKE SPACE 1809 00:59:59,265 --> 01:00:01,367 FOR SCIENTIFIC DISCOVERY, WHICH 1810 01:00:01,367 --> 01:00:04,070 BRINGS ME TO THE INTRODUCTION OF 1811 01:00:04,070 --> 01:00:06,873 THE NEW SIMONS FOUNDATION BRAND. 1812 01:00:06,873 --> 01:00:08,374 THIS IS OUR NEW LYINGO. 1813 01:00:08,374 --> 01:00:09,576 THROUGH OUR WORK AND THROUGH OUR 1814 01:00:09,576 --> 01:00:12,545 NEW LOGO, YOU CAN SEE, NOT SURE 1815 01:00:12,545 --> 01:00:15,348 IF YOU CAN SEE MY CURSOR BUT 1816 01:00:15,348 --> 01:00:17,984 THIS O IS WHAT WE CALL THE 1817 01:00:17,984 --> 01:00:18,284 SPOTLIGHT. 1818 01:00:18,284 --> 01:00:20,587 AND IT IS MEANT TO INVITE 1819 01:00:20,587 --> 01:00:21,955 CURIOSITY AND EXPLORATION. 1820 01:00:21,955 --> 01:00:24,424 AND THIS HELPS US ILLUMINATE OUR 1821 01:00:24,424 --> 01:00:27,460 VISION FOR OUR WORLD WHERE BASIC 1822 01:00:27,460 --> 01:00:28,561 SCIENCE MEAN AN ESSENTIAL DRIVER 1823 01:00:28,561 --> 01:00:33,600 OF PROGRESS AND OUR INNATE 1824 01:00:33,600 --> 01:00:35,068 CURIOSITY TO GUIDE. 1825 01:00:35,068 --> 01:00:36,803 SO YOU'LL SEE DIFFERENT 1826 01:00:36,803 --> 01:00:37,770 INDICATORS IN THE SPOTLIGHT, 1827 01:00:37,770 --> 01:00:39,505 LIKE OVER HERE ON THE RIGHT, 1828 01:00:39,505 --> 01:00:40,773 THAT WILL DENOTE DIFFERENT 1829 01:00:40,773 --> 01:00:44,410 PROGRAMS AND INITIATIVES AT THE 1830 01:00:44,410 --> 01:00:45,111 SIMONS FOUNDATION. 1831 01:00:45,111 --> 01:00:48,181 SO BACK TO NEUROSCIENCE AT THE 1832 01:00:48,181 --> 01:00:48,982 SIMONS FOUNDATION. 1833 01:00:48,982 --> 01:00:50,817 THREE PARTS I'LL TELL YOU ABOUT. 1834 01:00:50,817 --> 01:00:53,686 OUR AUTISM IN NEUROSCIENCE 1835 01:00:53,686 --> 01:00:54,888 DIVISION INCLUDES THE 1836 01:00:54,888 --> 01:00:55,622 NEUROSCIENCE COLLABORATIONS 1837 01:00:55,622 --> 01:00:57,490 WHICH I OVERSEE AND THE SIMONS 1838 01:00:57,490 --> 01:00:59,592 FOUNDATION AUTISM RESEARCH 1839 01:00:59,592 --> 01:00:59,893 INITIATIVE. 1840 01:00:59,893 --> 01:01:03,396 OUR SCIENCE SOCIETY AND CULTURE 1841 01:01:03,396 --> 01:01:05,565 WHICH INCLUDES THE TRANSMITTER. 1842 01:01:05,565 --> 01:01:08,701 AND OUR FLATIRON INSTITUTE WHICH 1843 01:01:08,701 --> 01:01:10,536 INCLUDES THE CENTER FOR 1844 01:01:10,536 --> 01:01:13,373 COMPUTATIONAL NEUROSCIENCE. 1845 01:01:13,373 --> 01:01:15,141 SO THE MISSION OF THE 1846 01:01:15,141 --> 01:01:16,776 NEUROSCIENCE COLLABORATIONS IS 1847 01:01:16,776 --> 01:01:18,912 TO SUPPORT AND CONVENE 1848 01:01:18,912 --> 01:01:21,447 SCIENTISTS TO THE ADDRESS 1849 01:01:21,447 --> 01:01:22,515 FUNDAMENTAL QUESTIONS ABOUT 1850 01:01:22,515 --> 01:01:23,049 BRAIN FUNCTION. 1851 01:01:23,049 --> 01:01:26,586 AND AGAIN WE ARE PART OF THE 1852 01:01:26,586 --> 01:01:28,121 NEUROSCIENCE OR AUTISM AND 1853 01:01:28,121 --> 01:01:30,390 NEUROSCIENCE DIVISION WHICH 1854 01:01:30,390 --> 01:01:31,291 INCLUDES SAFARI WHICH I'LL GET 1855 01:01:31,291 --> 01:01:33,092 TO IN MORE DETAIL IN A LITTLE 1856 01:01:33,092 --> 01:01:33,726 BIT. 1857 01:01:33,726 --> 01:01:35,595 IT'S A MORE PERMANENT INITIATIVE 1858 01:01:35,595 --> 01:01:37,430 OF THE SCIENCE FOUNDATION AND 1859 01:01:37,430 --> 01:01:38,998 IT'S OLDER AND HAS BEEN AROUND 1860 01:01:38,998 --> 01:01:42,702 LONGER THAN THE NEUROSIGNS 1861 01:01:42,702 --> 01:01:43,069 COLLABORATIONS. 1862 01:01:43,069 --> 01:01:44,737 SO WITHIN OUR NEUROSCIENCE 1863 01:01:44,737 --> 01:01:46,906 COLLABORATIONS SUBDIVISION, WE 1864 01:01:46,906 --> 01:01:49,342 HAVE TWO CURRENT COLLABORATIONS. 1865 01:01:49,342 --> 01:01:50,376 THE SIMONS COLLABORATION ON THE 1866 01:01:50,376 --> 01:01:52,312 GLOBAL BRAIN AND I'LL CALL IT 1867 01:01:52,312 --> 01:01:56,215 GLOBAL BRAIN OR SCGB AND THE 1868 01:01:56,215 --> 01:01:57,717 PLASTICITY AND THE AGING BRAIN. 1869 01:01:57,717 --> 01:02:03,423 I'LL CALL IT AGING BRAIN OR 1870 01:02:03,423 --> 01:02:05,124 SCPAB. 1871 01:02:05,124 --> 01:02:06,960 SO THE SIMONS CLAMERATION ON THE 1872 01:02:06,960 --> 01:02:08,895 GLOBAL BRAIN AIMS TO EXPAND OUR 1873 01:02:08,895 --> 01:02:10,697 UNDERSTANDING OF THE ROLE OF 1874 01:02:10,697 --> 01:02:13,299 INTERNAL BRAIN PROCESSES IN THE 1875 01:02:13,299 --> 01:02:15,535 ART FROM SENSATION TO ACTION 1876 01:02:15,535 --> 01:02:17,637 DISCOVERING THE NATURE, ROLE AND 1877 01:02:17,637 --> 01:02:19,706 MECHANISMS OF THE NEUROACTIVITY 1878 01:02:19,706 --> 01:02:29,315 THEY PRODUCES COGNITION. 1879 01:02:29,315 --> 01:02:31,017 SO THE GLOBAL BRAIN WAS STARTED 1880 01:02:31,017 --> 01:02:34,721 IN JULY OF 2014 AND WE CURRENTLY 1881 01:02:34,721 --> 01:02:37,390 FUND ABOUT JUST UNDER 100 1882 01:02:37,390 --> 01:02:38,925 INVESTIGATORS ACROSS ALMOST 30 1883 01:02:38,925 --> 01:02:39,826 COLLABORATIVE PROJECTS. 1884 01:02:39,826 --> 01:02:41,327 AND MOST OF THESE COLLABORATIVE 1885 01:02:41,327 --> 01:02:43,129 PROJECTS REALLY FOCUS ON 1886 01:02:43,129 --> 01:02:45,331 BRINGING TOGETHER SYSTEMS 1887 01:02:45,331 --> 01:02:46,933 NEUROSCIENTISTS, EXPERIMENTAL 1888 01:02:46,933 --> 01:02:49,435 NEUROSCIENTISTS, WITH 1889 01:02:49,435 --> 01:02:50,503 COMPUTATIONAL NEUROSCIENTISTS 1890 01:02:50,503 --> 01:02:52,105 AND THEORISTS. 1891 01:02:52,105 --> 01:02:54,507 IN ADDITION TO FUNDING RESEARCH, 1892 01:02:54,507 --> 01:02:57,110 WE HAVE A MISSION TO FACILITATE 1893 01:02:57,110 --> 01:02:58,244 COLLABORATION AND DATA SHARING 1894 01:02:58,244 --> 01:03:00,913 AND WE DO THIS THROUGH 1895 01:03:00,913 --> 01:03:02,115 WORKSHOPS, ANNUAL MEETINGS, 1896 01:03:02,115 --> 01:03:04,817 BUILDING PIPELINES TO PUT DATA 1897 01:03:04,817 --> 01:03:07,720 WITHOUT BORDERS FORMAT. 1898 01:03:07,720 --> 01:03:09,622 ENCOURAGING MANY OTHER 1899 01:03:09,622 --> 01:03:09,922 ACTIVITIES. 1900 01:03:09,922 --> 01:03:12,425 AND YOU CAN SEE HERE ON THE 1901 01:03:12,425 --> 01:03:15,728 RIGHT, THE NETWORK OF ALL OF OUR 1902 01:03:15,728 --> 01:03:17,864 INVESTIGATORS AND HOW THEY 1903 01:03:17,864 --> 01:03:18,231 OVERLAP. 1904 01:03:18,231 --> 01:03:20,066 THIS IS NOT JUST ON OUR PROJECTS 1905 01:03:20,066 --> 01:03:24,937 BUT ON PUB PUBLICATIONS WE FUND 1906 01:03:24,937 --> 01:03:26,139 OUTSIDE OF THE LAB AS WELL. 1907 01:03:26,139 --> 01:03:29,142 I THOUGHT LONG AND HARD WHICH 1908 01:03:29,142 --> 01:03:30,243 ACCOMPLISHMENTS COMING OUT WE 1909 01:03:30,243 --> 01:03:32,045 WANTED TO HIGHLIGHT HERE AND I 1910 01:03:32,045 --> 01:03:33,413 DECIDED THAT THERE WERE JUST SO 1911 01:03:33,413 --> 01:03:34,447 MANY AND IT WOULDN'T DO IT 1912 01:03:34,447 --> 01:03:38,851 JUSTICE TO TALK ABOUT SOME, SO 1913 01:03:38,851 --> 01:03:40,486 I'M ENCOURAGING YOU TO USE THE 1914 01:03:40,486 --> 01:03:42,355 QR CODE AND GO TO OUR WEBSITE 1915 01:03:42,355 --> 01:03:46,025 AND LOOK AT THE WORK WE ARE 1916 01:03:46,025 --> 01:03:46,259 DOING. 1917 01:03:46,259 --> 01:03:49,262 OUR SECOND NEUROSCIENCE 1918 01:03:49,262 --> 01:03:50,463 COLLABORATION IS CALLED THE 1919 01:03:50,463 --> 01:03:51,631 SCIENCE COLLABORATION ON 1920 01:03:51,631 --> 01:03:53,566 PLASTICITY AND THE AGING BRAIN. 1921 01:03:53,566 --> 01:03:55,234 AND THE WORK IN THIS 1922 01:03:55,234 --> 01:03:56,002 COLLABORATION AIMS TO DISCOVER 1923 01:03:56,002 --> 01:03:58,071 THE MECHANISMS OF RESILIENCE AND 1924 01:03:58,071 --> 01:03:59,505 MAINTENANCE IN THE AGING BRAIN 1925 01:03:59,505 --> 01:04:01,407 AND TO ESTABLISH A BASELINE FOR 1926 01:04:01,407 --> 01:04:03,609 AGE RELATED CHANGES IN 1927 01:04:03,609 --> 01:04:05,011 PLASTICITY ACROSS MANY MODEL 1928 01:04:05,011 --> 01:04:05,511 SYSTEMS. 1929 01:04:05,511 --> 01:04:08,181 AND THIS IS FLORIDA TO IDENTIFY 1930 01:04:08,181 --> 01:04:09,415 POTENTIAL INTERVENTIONS TO 1931 01:04:09,415 --> 01:04:13,786 MINIMIZE COGNITIVE DECLINE AND 1932 01:04:13,786 --> 01:04:14,520 EXTEND THE HEALTHY LIFESPAN. 1933 01:04:14,520 --> 01:04:18,291 THE AGING BRAIN STARTED IN MARCH 1934 01:04:18,291 --> 01:04:20,960 2020, EARLY MARCH 2020 AND WE 1935 01:04:20,960 --> 01:04:23,329 CURRENTLY FUND ABOUT 31 1936 01:04:23,329 --> 01:04:24,330 INVESTIGATORS ACROSS SEVEN 1937 01:04:24,330 --> 01:04:25,331 COLLABORATIVE PROJECTS. 1938 01:04:25,331 --> 01:04:27,400 AND AGAIN, AS WITH THE OTHER 1939 01:04:27,400 --> 01:04:28,835 NEUROSCIENCE COLLABORATION, OUR 1940 01:04:28,835 --> 01:04:31,437 GOAL IS ALSO TO FACILITATE 1941 01:04:31,437 --> 01:04:32,538 COLLABORATION AND DATA SHARING 1942 01:04:32,538 --> 01:04:35,475 THROUGH WORKSHOPS AND CONVENINGS 1943 01:04:35,475 --> 01:04:37,110 AND OTHER SUPPORTS. 1944 01:04:37,110 --> 01:04:38,444 AND ONE OF THE INTERESTING 1945 01:04:38,444 --> 01:04:40,213 FEATURES OF THE AGING BRAIN IS 1946 01:04:40,213 --> 01:04:43,816 THAT AT THE OUTSET, WE INITIATED 1947 01:04:43,816 --> 01:04:45,418 COLLABORATIVE WORKSHOPS ACROSS 1948 01:04:45,418 --> 01:04:48,054 ALL OF THE INVESTIGATORS TO 1949 01:04:48,054 --> 01:04:50,423 ALIGN THEIR PROJECTS ON TIME 1950 01:04:50,423 --> 01:04:52,325 POINTS, PROTOCOLS, MODEL 1951 01:04:52,325 --> 01:04:55,161 SYSTEMS, DATA MODALITIES AND 1952 01:04:55,161 --> 01:04:55,862 REALLY BIG DETAIL. 1953 01:04:55,862 --> 01:04:57,630 WE DID THIS WITH AN EYE TOWARDS 1954 01:04:57,630 --> 01:04:59,532 DIRECT COMPARISON OF ALL THE 1955 01:04:59,532 --> 01:05:00,633 DATA THAT WAS COMING OUT OF 1956 01:05:00,633 --> 01:05:04,437 THESE COLLABORATIVE AWARDS. 1957 01:05:04,437 --> 01:05:08,508 AND WE ALSO DID THIS IN ORDER TO 1958 01:05:08,508 --> 01:05:11,844 DO THIS DIRECT COMPARISON, WE 1959 01:05:11,844 --> 01:05:13,546 HAVE CREATED AGING BRAIN 1960 01:05:13,546 --> 01:05:13,980 DATABASE. 1961 01:05:13,980 --> 01:05:17,250 SO THIS QR CODE IS A LINK TO THE 1962 01:05:17,250 --> 01:05:19,886 START OF THIS AND SO IT'S AN 1963 01:05:19,886 --> 01:05:21,554 INFO GRAPHIC ON HOW THE PROJECTS 1964 01:05:21,554 --> 01:05:23,156 ALIGN AND COMPARISONS OF DATA WE 1965 01:05:23,156 --> 01:05:24,657 ARE DIRECTLY GOING TO BE ABLE TO 1966 01:05:24,657 --> 01:05:25,458 MAKE. 1967 01:05:25,458 --> 01:05:26,759 AND STOW NOW AS THE RESEARCHERS 1968 01:05:26,759 --> 01:05:28,561 ARE REALLY DEEPLY INTO 1969 01:05:28,561 --> 01:05:30,263 GENERATING THE DATA FROM THESE 1970 01:05:30,263 --> 01:05:32,265 AWARDS, WE ARE BUILDING THE 1971 01:05:32,265 --> 01:05:33,833 DATABASE TO ADJUST IT AND MAKE 1972 01:05:33,833 --> 01:05:35,268 THESE COMPARISONS AND THE PLAN 1973 01:05:35,268 --> 01:05:37,870 IS TO MAKE THIS AVAILABLE TO THE 1974 01:05:37,870 --> 01:05:39,305 ENTIRE SCIENTIFIC COMMUNITY AS 1975 01:05:39,305 --> 01:05:43,042 SOON AS WE POSSIBLY CAN. 1976 01:05:43,042 --> 01:05:45,144 WE ARE ALSO IN A VERY EXCITING 1977 01:05:45,144 --> 01:05:46,979 PLACE RIGHT NOW AT THE SIMONS 1978 01:05:46,979 --> 01:05:47,780 FOUNDATION. 1979 01:05:47,780 --> 01:05:49,382 WE ARE IN THE MIDDLE OF A 1980 01:05:49,382 --> 01:05:50,883 PROCESS TO IDENTIFY THE NEXT SET 1981 01:05:50,883 --> 01:05:54,754 OF NEUROSCIENCE COLLABORATIONS. 1982 01:05:54,754 --> 01:05:56,889 IMPORTANTLY, THE NEUROSCIENCE 1983 01:05:56,889 --> 01:05:57,957 COLLABORATIONS BY DESIGN ARE 1984 01:05:57,957 --> 01:05:59,158 TIME LIMITED. 1985 01:05:59,158 --> 01:06:01,694 THEY ARE MEANT TO BE 10 YEARS. 1986 01:06:01,694 --> 01:06:03,763 WHILE OUR OLDER NEUROSCIENCE 1987 01:06:03,763 --> 01:06:05,565 COLLABORATION IS LOOKING TOWARDS 1988 01:06:05,565 --> 01:06:06,766 SUNSETTING, WE ARE FIGURING OUT 1989 01:06:06,766 --> 01:06:08,367 WHAT AREAS WE ARE GOING TO 1990 01:06:08,367 --> 01:06:08,868 SUPPORT NEXT. 1991 01:06:08,868 --> 01:06:12,271 AND SO WE PUT OUT AN OPEN CALL 1992 01:06:12,271 --> 01:06:14,373 FOR VISION STATEMENTS FOR AREAS 1993 01:06:14,373 --> 01:06:15,908 OF NEUROSCIENCE POISED FOR HIGH 1994 01:06:15,908 --> 01:06:17,710 IMPACT FUNDING FROM US. 1995 01:06:17,710 --> 01:06:22,014 WITH A FOCUS ON SUB FIELDS WHERE 1996 01:06:22,014 --> 01:06:23,482 BRINGING TOGETHER TWO SUB FIELDS 1997 01:06:23,482 --> 01:06:24,784 THAT RARELY COMMUNICATE AND 1998 01:06:24,784 --> 01:06:26,686 COULD MAKE A BIG IMPACT AND 1999 01:06:26,686 --> 01:06:27,286 SIGNIFICANT PROCESS COULD BE 2000 01:06:27,286 --> 01:06:28,354 MADE TO OUR UNDERSTANDING IN THE 2001 01:06:28,354 --> 01:06:32,191 NEXT 10 YEARS. 2002 01:06:32,191 --> 01:06:34,994 WE RECEIVED 251 VISION 2003 01:06:34,994 --> 01:06:37,029 STATEMENTS AND THROUGH A VERY 2004 01:06:37,029 --> 01:06:38,297 COMPLICATED AND HARD PROCESS, IF 2005 01:06:38,297 --> 01:06:41,300 I'M BEING HONEST, WE NARROWED 2006 01:06:41,300 --> 01:06:44,303 THIS DOWN TO 20 PROPOSALS. 2007 01:06:44,303 --> 01:06:45,905 WE RECEIVED THOSE PROPOSALS 2008 01:06:45,905 --> 01:06:47,607 ABOUT TWO WEEKS AGO. 2009 01:06:47,607 --> 01:06:50,109 THEY ARE IN WITH GENERAL 2010 01:06:50,109 --> 01:06:53,713 CATEGORIES OF 2011 01:06:53,713 --> 01:06:54,413 NEUROIMMUNOINTERACTIONS, BRAIN 2012 01:06:54,413 --> 01:06:56,282 BODY, THE SOCIAL BRAIN AND 2013 01:06:56,282 --> 01:06:58,317 SOCIAL BEHAVIOR, OMICS AND 2014 01:06:58,317 --> 01:06:59,819 COMPUTATION, LEARNING AND 2015 01:06:59,819 --> 01:07:02,221 GENERALIZATION AND 2016 01:07:02,221 --> 01:07:03,789 NEURODEVELOPMENT AND 2017 01:07:03,789 --> 01:07:04,190 NEUROINTERACTIONS. 2018 01:07:04,190 --> 01:07:06,092 WE ARE DEEP IN REVIEW PROCESS 2019 01:07:06,092 --> 01:07:08,894 AND WE ARE GOING TO LIKELY 2020 01:07:08,894 --> 01:07:13,833 NARROW THIS DOWN TO PROX LET 2021 01:07:13,833 --> 01:07:15,301 FOUR-SIXER POTENTIAL 2022 01:07:15,301 --> 01:07:16,302 COLLABORATIONS FOR WORKSHOPS 2023 01:07:16,302 --> 01:07:18,004 BEFORE WE DECIDE WHICH THE ARE 2024 01:07:18,004 --> 01:07:22,608 NEXT AREAS WE SUPPORT. 2025 01:07:22,608 --> 01:07:25,878 NOW, ON TO ONE OF OUR BEST OR 2026 01:07:25,878 --> 01:07:27,880 MOST WELL-KNOWN INITIATIVES IN 2027 01:07:27,880 --> 01:07:29,315 NEUROSCIENCE AT THE SIMONS 2028 01:07:29,315 --> 01:07:29,715 FOUNDATION. 2029 01:07:29,715 --> 01:07:33,019 THE AUTISM RESEARCH INITIATIVE. 2030 01:07:33,019 --> 01:07:34,687 SAFARI HAS A MISSION TO IMPROVE 2031 01:07:34,687 --> 01:07:36,422 THE UNDERSTANDING, DIAGNOSIS AND 2032 01:07:36,422 --> 01:07:38,224 TREATMENT OF AUTISM SPECTRUM 2033 01:07:38,224 --> 01:07:39,925 DISORDERS BY FUNDING INNOVATIVE 2034 01:07:39,925 --> 01:07:42,128 RESEARCH OF THE HIGHEST QUALITY 2035 01:07:42,128 --> 01:07:45,298 AND RELEVANCE. 2036 01:07:45,298 --> 01:07:48,034 ONE OF THE WAYS TO MOST EASILY 2037 01:07:48,034 --> 01:07:49,935 UNDERSTAND THE ACTIVITIES OF 2038 01:07:49,935 --> 01:07:51,737 SAFARI IS TO CATEGORIZE THEM 2039 01:07:51,737 --> 01:07:53,839 INTO THREE BUCKETS. 2040 01:07:53,839 --> 01:07:56,709 THE FIRST BUCKET, IS CONVENINGS, 2041 01:07:56,709 --> 01:07:58,844 WORKSHOPS AND MEETINGS, BRINGING 2042 01:07:58,844 --> 01:08:00,046 INVESTIGATORS TOGETHER TO 2043 01:08:00,046 --> 01:08:01,213 EXCHANGE IDEAS. 2044 01:08:01,213 --> 01:08:03,849 THE NEXT IS GRANT MAKING. 2045 01:08:03,849 --> 01:08:06,452 A HOST OF DIFFERENT GRANT MAKING 2046 01:08:06,452 --> 01:08:08,154 MECHANISMS THAT SAFARI RUNS 2047 01:08:08,154 --> 01:08:08,954 WHERE THE INDIVIDUAL 2048 01:08:08,954 --> 01:08:09,855 INVESTIGATORS AND COLLABORATIVE 2049 01:08:09,855 --> 01:08:12,024 AWARDS AND EARLY CAREER AWARDS 2050 01:08:12,024 --> 01:08:14,760 OR EVEN INSTITUTIONAL SUPPORT. 2051 01:08:14,760 --> 01:08:16,629 AND ONE OF THE THINGS THAT 2052 01:08:16,629 --> 01:08:20,766 SAFARI DOES WELL IS GENERATE 2053 01:08:20,766 --> 01:08:22,968 RESOURCES BIOREPOSITORIES, 2054 01:08:22,968 --> 01:08:24,603 COHORTS AND OTHER DATA AND 2055 01:08:24,603 --> 01:08:33,546 ANIMAL MODEL RESOURCES. 2056 01:08:33,546 --> 01:08:35,815 ONE OF THE GREATEST IMPACTS IS 2057 01:08:35,815 --> 01:08:36,949 ON GENETICS OF AUTISM. 2058 01:08:36,949 --> 01:08:40,152 BACK I IN 2007, WE KNEW THAT 2059 01:08:40,152 --> 01:08:43,289 AUTISM WAS THE MOTOR HERITABLE 2060 01:08:43,289 --> 01:08:45,758 PSYCHIATRIC DISORDERS WHERE 2061 01:08:45,758 --> 01:08:46,892 BETWEEN 70-90% OF IDENTICAL 2062 01:08:46,892 --> 01:08:48,160 TWINS HAVE AUTISM. 2063 01:08:48,160 --> 01:08:51,330 THAT NUMBER GOES DOWN TO 31% OF 2064 01:08:51,330 --> 01:08:52,465 FRATERNAL TWINS WITH AUTISM AND 2065 01:08:52,465 --> 01:08:54,467 APPROXIMATELY 20% OF SIBLINGS 2066 01:08:54,467 --> 01:08:56,502 BOTH HAVE AUTISM. 2067 01:08:56,502 --> 01:08:58,371 WHICH TELLS US THAT THE RISK IS 2068 01:08:58,371 --> 01:09:03,042 BOTH GENETIC AND ENVIRONMENTAL. 2069 01:09:03,042 --> 01:09:04,643 AND IN ORDER TO INVESTIGATE THE 2070 01:09:04,643 --> 01:09:08,381 GENETIC PORTION OF THIS RISK, 2071 01:09:08,381 --> 01:09:11,450 SAFARI MADE LARGE INVESTMENTS IN 2072 01:09:11,450 --> 01:09:12,852 COHORTS, GENE DISCOVERY AND OPEN 2073 01:09:12,852 --> 01:09:16,655 SCIENCE SINCE ABOUT 2006. 2074 01:09:16,655 --> 01:09:22,795 ONE OF THE FIRST INVESTMENTS WAS 2075 01:09:22,795 --> 01:09:23,396 THE SIMONS SIMPLEX COLLECTION 2076 01:09:23,396 --> 01:09:27,400 WHICH INCLUDES 2,600 FAMILIES OF 2077 01:09:27,400 --> 01:09:28,768 AT LEAST ONE PERSON DIAGNOSED 2078 01:09:28,768 --> 01:09:29,802 WITH AUTISM. 2079 01:09:29,802 --> 01:09:32,872 WE ALSO HAVE TWO OTHER LARGE 2080 01:09:32,872 --> 01:09:35,374 COHORTS, SPARK, SIMONS POWERING 2081 01:09:35,374 --> 01:09:37,676 AUTISM RESEARCH, A PHENOTYPE 2082 01:09:37,676 --> 01:09:40,513 FIRST COHORT WHERE RIGHT NOW WE 2083 01:09:40,513 --> 01:09:43,482 HAVE OVER 325,000 PARTICIPANTS 2084 01:09:43,482 --> 01:09:46,786 OF WHICH ABOUT 125,000 HAVE 2085 01:09:46,786 --> 01:09:47,019 AUTISM. 2086 01:09:47,019 --> 01:09:52,525 WE ALSO HAVE A GENES FIRST 2087 01:09:52,525 --> 01:09:53,859 COHORT WHERE THERE ARE 2088 01:09:53,859 --> 01:09:55,728 APPROXIMATELY 7000 PARTICIPANTS 2089 01:09:55,728 --> 01:09:59,265 AND 180 GENE GROUPS. 2090 01:09:59,265 --> 01:10:01,767 AND IN A JOINT INITIATIVE WITH 2091 01:10:01,767 --> 01:10:04,570 THE NANCY LORI MARKS FAMILY 2092 01:10:04,570 --> 01:10:07,206 FOUNDATION, WE ALSO HAVE THE AIC 2093 01:10:07,206 --> 01:10:10,276 WHICH IS AN EFFORT TO GENERATE 2094 01:10:10,276 --> 01:10:12,211 INDUCED PLURIPOTENT STEM CELLS 2095 01:10:12,211 --> 01:10:13,913 FROM BLOOD SAMPLES OF 2096 01:10:13,913 --> 01:10:16,115 PARTICIPANTS IN THE SIMON SEARCH 2097 01:10:16,115 --> 01:10:18,484 LIGHT COHORT. 2098 01:10:18,484 --> 01:10:22,087 AND THROUGH THIS WORK, SAFARI 2099 01:10:22,087 --> 01:10:24,190 MADE MAJOR PROGRESS ON THE 2100 01:10:24,190 --> 01:10:25,257 GENETICS OF AUTISM. 2101 01:10:25,257 --> 01:10:28,894 SPARK ALONE HAS IDENTIFIED 167 2102 01:10:28,894 --> 01:10:30,529 GENES AND 43 COPY NUMBER 2103 01:10:30,529 --> 01:10:32,031 VARIATIONS THAT ARE 2104 01:10:32,031 --> 01:10:34,066 SIGNIFICANTLY ASSOCIATED WITH 2105 01:10:34,066 --> 01:10:35,267 AUTISM SPECTRUM DISORDER. 2106 01:10:35,267 --> 01:10:37,303 AND THIS SLIDE IS SMALL AND HARD 2107 01:10:37,303 --> 01:10:37,970 TO READ. 2108 01:10:37,970 --> 01:10:39,505 THEY ARE LISTED HERE AND THESE 2109 01:10:39,505 --> 01:10:41,273 SLIDES ARE IN YOUR MEETING NOTES 2110 01:10:41,273 --> 01:10:45,945 IF YOU WANT TO LOOK AT THIS THE 2111 01:10:45,945 --> 01:10:46,512 A LITTLE BIT MORE CLOSELY. 2112 01:10:46,512 --> 01:10:48,380 AND SAFARI ALSO ACKNOWLEDGES 2113 01:10:48,380 --> 01:10:50,382 THAT GENES ARE ONLY PART OF THE 2114 01:10:50,382 --> 01:10:52,117 PICTURE TO TRULY UNDERSTAND 2115 01:10:52,117 --> 01:10:52,618 AUTISM. 2116 01:10:52,618 --> 01:10:56,388 AND SAFARI ALSO HAS RESEARCH 2117 01:10:56,388 --> 01:10:58,090 FROM OTHER LEVELS FROM NETWORKS 2118 01:10:58,090 --> 01:10:59,124 TO CIRCUITS TO BEHAVIOR. 2119 01:10:59,124 --> 01:11:00,593 THIS IS ALL SOMETHING THEY ARE 2120 01:11:00,593 --> 01:11:01,927 INVESTING DEEPLY IN, ESPECIALLY 2121 01:11:01,927 --> 01:11:04,797 AS THEY LOOK AT THE NEXT -- THE 2122 01:11:04,797 --> 01:11:07,066 FUTURE OF SAFARI. 2123 01:11:07,066 --> 01:11:09,702 JUST TO GIVE YOU ONE EXAMPLE OF 2124 01:11:09,702 --> 01:11:10,936 HARNESSING THE RESEARCH POWER OF 2125 01:11:10,936 --> 01:11:12,505 THESE COHORTS TO INVESTIGATE AND 2126 01:11:12,505 --> 01:11:13,772 UNDERSTAND AUTISM, I WANTED TO 2127 01:11:13,772 --> 01:11:16,709 TELL YOU A LITTLE BIT ABOUT THIS 2128 01:11:16,709 --> 01:11:20,112 PROJECT BEING CONDUCTED WHO IS 2129 01:11:20,112 --> 01:11:22,314 CURRENTLY SERVING ON THE 2130 01:11:22,314 --> 01:11:24,717 ACADEMIC SABBATICAL AT THE 2131 01:11:24,717 --> 01:11:25,618 SIMONS FOUNDATION. 2132 01:11:25,618 --> 01:11:28,320 HE IS USING WEARABLE DEVICES 2133 01:11:28,320 --> 01:11:29,622 COMBINED WITH PATIENT 2134 01:11:29,622 --> 01:11:31,524 QUESTIONNAIRES AND A SLEEP DIARY 2135 01:11:31,524 --> 01:11:33,192 TO PHENOTYPE THE SLEEP PATTERNS 2136 01:11:33,192 --> 01:11:35,594 OF 100 FAMILIES FROM THE SPARK 2137 01:11:35,594 --> 01:11:35,928 COHORT. 2138 01:11:35,928 --> 01:11:38,030 SO ONE OF THE GREAT FEATURES OF 2139 01:11:38,030 --> 01:11:39,598 THE SPARK INITIATIVE IS FAMILIES 2140 01:11:39,598 --> 01:11:41,534 CAN INDICATE ON SIGN UP WHETHER 2141 01:11:41,534 --> 01:11:43,202 OR NOT THEY ARE WILLING TO BE 2142 01:11:43,202 --> 01:11:46,138 RECONTACTED FOR FUTURE RESEARCH 2143 01:11:46,138 --> 01:11:46,739 PROJECTS. 2144 01:11:46,739 --> 01:11:48,307 AND SO HE AND HIS TEAM ARE 2145 01:11:48,307 --> 01:11:49,842 RECORDING EACH PARTICIPANT WITH 2146 01:11:49,842 --> 01:11:51,944 THESE DEVICES FOR ABOUT 2-3 2147 01:11:51,944 --> 01:11:54,647 WEEKS EVERY NIGHT AND REALLY 2148 01:11:54,647 --> 01:11:57,516 AWESOME PART OF THIS IS THEY ARE 2149 01:11:57,516 --> 01:11:59,018 MEDICINALLY RELEASING THE RAW 2150 01:11:59,018 --> 01:12:00,052 DATA TO THE COMMUNITY. 2151 01:12:00,052 --> 01:12:02,221 SO IT CAN ALL BE ACCESSED. 2152 01:12:02,221 --> 01:12:05,457 AND THIS IS A PART OF A LARGER 2153 01:12:05,457 --> 01:12:08,227 PURGE FOR DEEPER PHENOTYPING OF 2154 01:12:08,227 --> 01:12:10,596 AUTISM SPECTRUM DISORDER. 2155 01:12:10,596 --> 01:12:12,398 NOW IN ADDITION TO THE COHORTS 2156 01:12:12,398 --> 01:12:14,233 AND INVESTIGATION INTO THE 2157 01:12:14,233 --> 01:12:17,036 GENETICS OF AUTISM, SAFARI FUNDS 2158 01:12:17,036 --> 01:12:19,171 RESEARCH ON THE BASIC SCIENCE 2159 01:12:19,171 --> 01:12:20,639 UNDERLYING AUTISM AND PROVIDES A 2160 01:12:20,639 --> 01:12:23,542 HOST OF RESOURCES ON THE AUTISM 2161 01:12:23,542 --> 01:12:24,276 BRAIN. 2162 01:12:24,276 --> 01:12:27,446 A REPOSITORY OF BRAINS FROM 2163 01:12:27,446 --> 01:12:30,349 PEOPLE WITH AUTISM FOR RESEARCH 2164 01:12:30,349 --> 01:12:30,649 PURPOSES. 2165 01:12:30,649 --> 01:12:34,453 THERE IS REPOSITORY FOR CELL 2166 01:12:34,453 --> 01:12:35,854 MODELS WITH THE NANCY LORI MARKS 2167 01:12:35,854 --> 01:12:36,455 FOUNDATION. 2168 01:12:36,455 --> 01:12:38,924 WE HAVE MOUSE MODELS OF AUTISM 2169 01:12:38,924 --> 01:12:39,658 AVAILABLE. 2170 01:12:39,658 --> 01:12:43,429 RAT MODELS AVAILABLE, ZEBRAFISH 2171 01:12:43,429 --> 01:12:44,363 MODELS. 2172 01:12:44,363 --> 01:12:46,966 SAFARI GENE AND SAFARI BASE IS A 2173 01:12:46,966 --> 01:12:48,767 REPOSITORY OF GENETIC 2174 01:12:48,767 --> 01:12:49,935 INFORMATION ALONG WITH DATA 2175 01:12:49,935 --> 01:12:50,936 ANALYSIS AND TOOLS AND THE 2176 01:12:50,936 --> 01:12:53,939 RESEARCH MATCH I JUST TOLD YOU 2177 01:12:53,939 --> 01:12:54,940 USING FOR THE SLEEP STUDY 2178 01:12:54,940 --> 01:12:56,075 THROUGH SPARK. 2179 01:12:56,075 --> 01:12:59,778 WE ALSO ARE CONDUCTING CLINICAL 2180 01:12:59,778 --> 01:13:03,549 RESEARCH TRIAL THROUGH CLINICAL 2181 01:13:03,549 --> 01:13:09,221 RESEARCH ASSOCIATES ON ON AUT 2182 01:13:09,221 --> 01:13:09,455 AUTISM. 2183 01:13:09,455 --> 01:13:12,057 ACROSS ALL OF OUR AUTISM AND 2184 01:13:12,057 --> 01:13:13,892 NEUROSCIENCE DIVISION, WE RUN 2185 01:13:13,892 --> 01:13:15,661 EARLY CAREER PROGRAMS. 2186 01:13:15,661 --> 01:13:18,197 AND SO WE RECOGNIZE THE 2187 01:13:18,197 --> 01:13:22,067 DIVERSITY AMONG INVESTIGATORS 2188 01:13:22,067 --> 01:13:22,668 IMPROVES INNOVATION AND 2189 01:13:22,668 --> 01:13:23,636 SCIENTIFIC COLLABORATION. 2190 01:13:23,636 --> 01:13:25,571 OUR EARLY CAREER PROGRAMS AIM TO 2191 01:13:25,571 --> 01:13:27,906 CRATE PATHWAYS, ADVANCE CAREERS 2192 01:13:27,906 --> 01:13:29,575 AND WORK COLLABORATIVELY TO 2193 01:13:29,575 --> 01:13:32,211 CREATE A MORE INCLUSIVE RESEARCH 2194 01:13:32,211 --> 01:13:32,745 ENVIRONMENT. 2195 01:13:32,745 --> 01:13:35,481 WE HOPE TO WELCOME NEW VOICES, 2196 01:13:35,481 --> 01:13:37,783 PERSPECTIVES, EXPERIENCE, 2197 01:13:37,783 --> 01:13:41,086 TRAINING BACKGROUNDS AND IN THE 2198 01:13:41,086 --> 01:13:42,688 SCIENTIFIC COMMUNITY SO WE CAN 2199 01:13:42,688 --> 01:13:44,390 BENEFIT FROM EVERYONE'S 2200 01:13:44,390 --> 01:13:45,391 CONTRIBUTIONS. 2201 01:13:45,391 --> 01:13:47,826 SO WE HAVE TWO EARLY CAREER 2202 01:13:47,826 --> 01:13:49,294 PROGRAMS FOCUSED ON TWO 2203 01:13:49,294 --> 01:13:50,262 DIFFERENT STAGES. 2204 01:13:50,262 --> 01:13:52,364 THE FIRST ARE THE INDEPENDENCE 2205 01:13:52,364 --> 01:13:55,367 AWARDS AND THESE ARE FOCUSED OAT 2206 01:13:55,367 --> 01:13:57,102 TRANSITION FROM SENIOR POSTDOC 2207 01:13:57,102 --> 01:13:58,103 TO JUNIOR FACULTY. 2208 01:13:58,103 --> 01:14:01,106 THESE ARE VERY SIMILAR IN SCOPE 2209 01:14:01,106 --> 01:14:04,176 TO THE K99 RO1 MECHANISM RUN BY 2210 01:14:04,176 --> 01:14:05,411 THE NIH. 2211 01:14:05,411 --> 01:14:07,379 AND SO, THESE ARE FOR SENIOR 2212 01:14:07,379 --> 01:14:09,081 POSTDOCS FROM UNDERREPRESENTED 2213 01:14:09,081 --> 01:14:11,417 GROUPS ACTIVELY SEEKING FACULTY 2214 01:14:11,417 --> 01:14:11,684 POSITIONS. 2215 01:14:11,684 --> 01:14:15,054 THEY RUN ACROSS ALL OF OUR 2216 01:14:15,054 --> 01:14:16,689 PROGRAMS, THE GLOBAL BRAIN, 2217 01:14:16,689 --> 01:14:18,123 AGING BRAIN AND SAFARI. 2218 01:14:18,123 --> 01:14:19,792 NEXT YEAR, BECAUSE OF THE 2219 01:14:19,792 --> 01:14:21,193 SUNSETTING OF THE GLOBAL BRAIN, 2220 01:14:21,193 --> 01:14:22,594 THEY ARE JUST GOING TO BE RUN 2221 01:14:22,594 --> 01:14:24,997 OUT OF THE AGING BRAIN AND 2222 01:14:24,997 --> 01:14:26,999 SAFARI, BUT WE WILL EXPAND THESE 2223 01:14:26,999 --> 01:14:29,435 INTO THE SCIENTIFIC AREAS OF THE 2224 01:14:29,435 --> 01:14:31,704 NEW COLLABORATIONS AS SOON AS 2225 01:14:31,704 --> 01:14:32,571 THOSE ARE IDENTIFIED. 2226 01:14:32,571 --> 01:14:35,808 THEY PROVIDE UP TO TWO YEARS OF 2227 01:14:35,808 --> 01:14:39,011 POSTDOCTORAL FUNDING AND 3 YEAR 2228 01:14:39,011 --> 01:14:40,179 RESEARCH AWARD UPON ACCEPTANCE 2229 01:14:40,179 --> 01:14:42,681 OF A FACULTY POSITION. 2230 01:14:42,681 --> 01:14:44,216 THE NEXT EARLY CAREER PROGRAM 2231 01:14:44,216 --> 01:14:46,752 THAT WE SUPPORT IS CALLED THE 2232 01:14:46,752 --> 01:14:47,820 UNDERGRADUATE RESEARCH 2233 01:14:47,820 --> 01:14:50,022 FELLOWSHIP IN NEUROSCIENCE. 2234 01:14:50,022 --> 01:14:56,595 THIS IS NAMED AFTER SHA NOW WHO 2235 01:14:56,595 --> 01:14:57,496 HAD GREAT INFLUENCE OVER OUR 2236 01:14:57,496 --> 01:14:58,430 SIMONS COLLABORATION ON GLOBAL 2237 01:14:58,430 --> 01:14:58,630 BRAIN. 2238 01:14:58,630 --> 01:15:01,433 AND REALLY IS A TESTAMENT TO HIS 2239 01:15:01,433 --> 01:15:03,535 FOCUS ON TRAINING AND MENTORING. 2240 01:15:03,535 --> 01:15:05,437 AND THE GOAL OF THIS PROGRAM IS 2241 01:15:05,437 --> 01:15:08,207 TO SPARK AND SUSTAIN INTEREST IN 2242 01:15:08,207 --> 01:15:10,042 NEUROSCIENCE AMONG UNDERGRADUATE 2243 01:15:10,042 --> 01:15:10,809 STUDENTS FROM DIVERSE 2244 01:15:10,809 --> 01:15:12,211 BACKGROUNDS, UNDER REPRESENTED 2245 01:15:12,211 --> 01:15:14,613 IN NEUROSCIENCE RESEARCH. 2246 01:15:14,613 --> 01:15:16,615 SO ONE OF THE INTERESTING 2247 01:15:16,615 --> 01:15:19,118 FEATURES OF THIS PROGRAM IS, WE 2248 01:15:19,118 --> 01:15:21,019 SOLICIT FROM ANYONE WE FUND 2249 01:15:21,019 --> 01:15:22,221 ACROSS GLOBAL BRAIN, AGING BRAIN 2250 01:15:22,221 --> 01:15:24,723 AND SAFARI, THE OPPORTUNITY TO 2251 01:15:24,723 --> 01:15:26,859 HOST A UNDERGRADUATE AND ASK 2252 01:15:26,859 --> 01:15:31,530 THEM TO PROVIDE, TO DESIGNATE A 2253 01:15:31,530 --> 01:15:32,731 MENTOR FOR THE UNDERGRADUATE, 2254 01:15:32,731 --> 01:15:35,033 WHETHER IT BE GRAD STUDENT, 2255 01:15:35,033 --> 01:15:37,636 POSTDOC OR STAFF SCIENTIST. 2256 01:15:37,636 --> 01:15:40,239 AND WRITE UP A SMALL -- GIVE US 2257 01:15:40,239 --> 01:15:41,540 INFORMATION ON THE PROJECT OF 2258 01:15:41,540 --> 01:15:42,841 THE UNDERGRADUATE WHY WILL BE 2259 01:15:42,841 --> 01:15:44,510 WORKING ON. 2260 01:15:44,510 --> 01:15:48,247 ONCE WE HAVE THOSE, WE PUT A PIN 2261 01:15:48,247 --> 01:15:50,749 IN EACH OF THE OPPORTUNITIES ARE 2262 01:15:50,749 --> 01:15:51,717 GEOGRAPHICALLY. 2263 01:15:51,717 --> 01:15:53,051 AND DRAW A CIRCLE AROUND IT. 2264 01:15:53,051 --> 01:15:54,219 AND THIS IS BECAUSE FIRST OF 2265 01:15:54,219 --> 01:15:56,555 ALL, WE WANT THIS TO BE AN 2266 01:15:56,555 --> 01:15:57,556 IN-PERSON RESEARCH EXPERIENCE. 2267 01:15:57,556 --> 01:16:01,260 AND THEN, WE REACH OUT TO ANY 2268 01:16:01,260 --> 01:16:02,427 DEGREE GRANTING INSTITUTION IN 2269 01:16:02,427 --> 01:16:04,329 THAT CATCH MAN AREA AND WHETHER 2270 01:16:04,329 --> 01:16:07,599 THEY BE COMMUNITY COLLEGES, 2271 01:16:07,599 --> 01:16:10,836 ANYONE WHO GRANTS A DEGREE, AND 2272 01:16:10,836 --> 01:16:12,437 INVITE THEM UNDERGRADS TO APPLY. 2273 01:16:12,437 --> 01:16:14,373 SO THEY DON'T HAVE TO BE AT THE 2274 01:16:14,373 --> 01:16:15,541 SAME INSTITUTION WHERE THE LAB 2275 01:16:15,541 --> 01:16:17,242 ALREADY IS. 2276 01:16:17,242 --> 01:16:20,646 WE PROVIDE A GOOD SALARY TO WORK 2277 01:16:20,646 --> 01:16:22,114 FOR 10 HOURS A WEEK FOR THE 2278 01:16:22,114 --> 01:16:22,948 ENTIRE ACADEMIC YEAR. 2279 01:16:22,948 --> 01:16:25,150 AND IMPORTANTLY, WHEN WE ARE 2280 01:16:25,150 --> 01:16:27,452 VALUING THE APPLICATIONS OF THE 2281 01:16:27,452 --> 01:16:30,589 UNDERGRADUATES, WE COUNTER 2282 01:16:30,589 --> 01:16:31,690 WEIGHT PAST EXPERIENCE IN 2283 01:16:31,690 --> 01:16:32,291 RESEARCH. 2284 01:16:32,291 --> 01:16:34,560 SO THOSE WHO HAVE NOT HAD 2285 01:16:34,560 --> 01:16:35,527 RESEARCH EXPERIENCE ARE GOING TO 2286 01:16:35,527 --> 01:16:38,230 BE MORE LIKELY TO GET A RESEARCH 2287 01:16:38,230 --> 01:16:38,564 OPPORTUNITY. 2288 01:16:38,564 --> 01:16:42,367 AND RIGHT NOW, THE UNDERGRAD 2289 01:16:42,367 --> 01:16:43,969 APPLICATIONS ARE -- WILL BE OPEN 2290 01:16:43,969 --> 01:16:46,205 ON MARCH 23 AND THEY WILL BE DUE 2291 01:16:46,205 --> 01:16:47,139 MAY 4. 2292 01:16:47,139 --> 01:16:48,373 SO IF YOU FOLLOW THIS QR CODE 2293 01:16:48,373 --> 01:16:50,976 AND YOU KNOW ANY GREAT 2294 01:16:50,976 --> 01:16:51,877 UNDERGRADS WHO MIGHT BE ABLE TO 2295 01:16:51,877 --> 01:16:53,178 COMMUTE TO ONE OF THE PLACES, 2296 01:16:53,178 --> 01:16:54,780 WHICH ARE ALL GOING TO BE LISTED 2297 01:16:54,780 --> 01:16:56,782 ON THE WEBSITE VERY SOON, PLEASE 2298 01:16:56,782 --> 01:16:59,084 ENCOURAGE THEM TO APPLY. 2299 01:16:59,084 --> 01:17:00,853 IN ADDITION TO JUST THE RESEARCH 2300 01:17:00,853 --> 01:17:02,955 FUNDING AND THE MATCHING, WE 2301 01:17:02,955 --> 01:17:04,957 PROVIDE INCLUSIVE MENTORING, 2302 01:17:04,957 --> 01:17:08,260 TRAINING FOR THE MENTORS, CODING 2303 01:17:08,260 --> 01:17:10,963 CAMP FOR THE UNDERGRADS, CAREER 2304 01:17:10,963 --> 01:17:11,964 DEVELOPMENT THINGS LIKE HELP 2305 01:17:11,964 --> 01:17:13,765 WITH GRAD SCHOOL AND POSTBAC 2306 01:17:13,765 --> 01:17:14,967 APPLICATIONS AND GUIDANCE. 2307 01:17:14,967 --> 01:17:16,668 WE ALSO FACILITATE COMMUNITY 2308 01:17:16,668 --> 01:17:19,171 MOSTLY VIRTUALLY BECAUSE THIS IS 2309 01:17:19,171 --> 01:17:19,471 DISTRIBUTED. 2310 01:17:19,471 --> 01:17:20,873 AND WE BRING EVERYONE TOGETHER 2311 01:17:20,873 --> 01:17:23,842 ONCE A YEAR FOR RESEARCH 2312 01:17:23,842 --> 01:17:27,379 SYMPOSIUM AT THE SIMONS 2313 01:17:27,379 --> 01:17:27,679 FOUNDATION. 2314 01:17:27,679 --> 01:17:30,082 SO JUST TO TELL YOU ABOUT SOME 2315 01:17:30,082 --> 01:17:30,816 UPCOMING FUNDING OPPORTUNITIES 2316 01:17:30,816 --> 01:17:33,385 OUT OF OUR AUTISM AND 2317 01:17:33,385 --> 01:17:33,952 NEUROSCIENCE DIVISION. 2318 01:17:33,952 --> 01:17:36,288 FROM SAFARI, THERE ARE TWO 2319 01:17:36,288 --> 01:17:38,090 UPCOMING OPEN RFAs. 2320 01:17:38,090 --> 01:17:39,892 ONE IS FOR PILOT AND 2321 01:17:39,892 --> 01:17:40,726 CONTINUATION FUNDING. 2322 01:17:40,726 --> 01:17:44,329 AND THIS ONE IS FOR NOVEL 2323 01:17:44,329 --> 01:17:45,397 EXPLORATORY, HIGH RISK AND 2324 01:17:45,397 --> 01:17:48,533 POTENTIALLY HIGH IMPACT PROJECTS 2325 01:17:48,533 --> 01:17:50,369 STUDYING AUTISM SPECTRUM 2326 01:17:50,369 --> 01:17:50,636 DISORDER. 2327 01:17:50,636 --> 01:17:52,204 AND THERE IS TWO PARTS, EITHER 2328 01:17:52,204 --> 01:17:53,805 FIRST YOU MUST GET A PILOT AWARD 2329 01:17:53,805 --> 01:17:56,208 AND THEN ONCE THE PILOT AWARD IS 2330 01:17:56,208 --> 01:17:57,609 SUCCESSFUL, YOU CAN APPLY TO THE 2331 01:17:57,609 --> 01:17:59,912 SAME RFA FOR A CONTINUATION 2332 01:17:59,912 --> 01:18:00,379 AWARD. 2333 01:18:00,379 --> 01:18:02,014 WE ARE GOING TO BE RUNNING A 2334 01:18:02,014 --> 01:18:05,117 TARGETED RFA OUT OF SAFARI 2335 01:18:05,117 --> 01:18:06,852 BRIDGING EARLY NEURODEVELOPMENT 2336 01:18:06,852 --> 01:18:08,420 AND EMERGING NEUROCIRCUITS. 2337 01:18:08,420 --> 01:18:12,624 THIS RFA WILL THE INVITE 2338 01:18:12,624 --> 01:18:14,293 DEVELOPMENTAL NEUROBIOLOGISTS TO 2339 01:18:14,293 --> 01:18:15,694 COLLABORATE TO IDENTIFY 2340 01:18:15,694 --> 01:18:17,529 CONVERGENT CHANGES IN AUTISM 2341 01:18:17,529 --> 01:18:18,263 RELEVANT CIRCUITS. 2342 01:18:18,263 --> 01:18:19,932 AND IF YOU FOLLOW THE QR CODE 2343 01:18:19,932 --> 01:18:20,933 HERE YOU CAN GET MORE 2344 01:18:20,933 --> 01:18:24,937 INFORMATION ON BOTH OF THOSE. 2345 01:18:24,937 --> 01:18:27,339 WE ARE ALSO GOING TO BE HAVING A 2346 01:18:27,339 --> 01:18:28,540 NEUROSCIENCE COURSES AND 2347 01:18:28,540 --> 01:18:29,808 CONFERENCES RFA. 2348 01:18:29,808 --> 01:18:32,511 AND APPLICATIONS FOR THIS OPEN 2349 01:18:32,511 --> 01:18:35,147 APRIL 1 AND THEY ARE DUE ABOUT A 2350 01:18:35,147 --> 01:18:35,747 MONTH AND A HALF LATER. 2351 01:18:35,747 --> 01:18:37,683 AND WE ARE SEEKING TO FUND 2352 01:18:37,683 --> 01:18:40,652 COURSES OR CONFERENCES IN 2353 01:18:40,652 --> 01:18:40,986 NEUROSCIENCE. 2354 01:18:40,986 --> 01:18:42,554 WE WILL PRIORITIZE COURSES AND 2355 01:18:42,554 --> 01:18:44,222 CONFERENCE THAT IS ALIGN WITH 2356 01:18:44,222 --> 01:18:45,657 OUR SCIENTIFIC MISSIONS OF THE 2357 01:18:45,657 --> 01:18:48,460 GLOBAL BRAIN AND THE AGING BRAIN 2358 01:18:48,460 --> 01:18:50,529 BUT WE WELCOME APPLICATIONS FROM 2359 01:18:50,529 --> 01:18:53,632 ANY COURSE OR CONFERENCE ACROSS 2360 01:18:53,632 --> 01:18:54,032 NEUROSCIENCE. 2361 01:18:54,032 --> 01:18:55,867 AND WE ALSO HIGHLY ENCOURAGE 2362 01:18:55,867 --> 01:18:57,235 APPLICATIONS FOR COURSES AND 2363 01:18:57,235 --> 01:18:59,638 CONFERENCES THAT ARE HELD OR 2364 01:18:59,638 --> 01:19:00,973 ORGANIZED BY PEOPLE IN REGIONS 2365 01:19:00,973 --> 01:19:02,140 OF THE WORLD FOR OPPORTUNITIES 2366 01:19:02,140 --> 01:19:05,177 FOR NEUROSCIENCE COURSES AND 2367 01:19:05,177 --> 01:19:07,446 CONFERENCES. 2368 01:19:07,446 --> 01:19:09,848 THIS COURSES AND CONFERENCES RFA 2369 01:19:09,848 --> 01:19:12,951 IS MODELED OFF OF ONE THAT WE 2370 01:19:12,951 --> 01:19:14,152 DID IN THE GLOBAL BRAIN 2371 01:19:14,152 --> 01:19:16,054 EXTREMELY SUCCESSFUL AND IS 2372 01:19:16,054 --> 01:19:16,955 TRULY WORLDWIDE. 2373 01:19:16,955 --> 01:19:18,890 WE FUND COURSES THROUGH THE 2374 01:19:18,890 --> 01:19:20,459 GLOBAL RUN CURRENTLY IN PLACES 2375 01:19:20,459 --> 01:19:22,160 FROM SOUTH AFRICA TO THE MIDDLE 2376 01:19:22,160 --> 01:19:24,763 EAST, TO INDIA TO CHINA. 2377 01:19:24,763 --> 01:19:25,998 AND TO THE UNITED STATES. 2378 01:19:25,998 --> 01:19:28,700 AND SO WE HOPE TO REPLICATE 2379 01:19:28,700 --> 01:19:30,268 SOMETHING SORT OF PAN 2380 01:19:30,268 --> 01:19:33,171 NEUROSCIENCE HERE AS WELL. 2381 01:19:33,171 --> 01:19:34,873 ANOTHER FUNDING OPPORTUNITY I 2382 01:19:34,873 --> 01:19:36,308 WANTED TO LET THIS GROUP KNOW 2383 01:19:36,308 --> 01:19:38,176 ABOUT, THAT IS NOT STRICTLY 2384 01:19:38,176 --> 01:19:40,045 NEUROSCIENCE BUT ENCOMPASSES 2385 01:19:40,045 --> 01:19:41,680 NEUROSCIENCE IS THE SCIENCE 2386 01:19:41,680 --> 01:19:43,148 FOUNDATION PIVOT FELLOWSHIP. 2387 01:19:43,148 --> 01:19:46,018 WHAT THIS IS, WE ARE LOOKING FOR 2388 01:19:46,018 --> 01:19:47,486 FACULTY MEMBERS WITH A STRONG 2389 01:19:47,486 --> 01:19:49,554 TRACK RECORD OF SUCCESS IN 2390 01:19:49,554 --> 01:19:51,289 ACHIEVEMENT IN THE CURRENT 2391 01:19:51,289 --> 01:19:51,490 FIELD. 2392 01:19:51,490 --> 01:19:52,758 THAT ARE LOOKING TO MAKE A PIVOT 2393 01:19:52,758 --> 01:19:55,460 AND HAVE A DEEP INTEREST IN 2394 01:19:55,460 --> 01:19:57,362 CURIOSITY AND DRIVE TO MAKE 2395 01:19:57,362 --> 01:19:59,064 CONTRIBUTIONS TO NEW DISCIPLINE. 2396 01:19:59,064 --> 01:20:01,299 THE WAY THIS IS SET UP IS THAT 2397 01:20:01,299 --> 01:20:03,268 WE WILL FUND ONE TRAINING YEAR 2398 01:20:03,268 --> 01:20:05,370 WHERE THE FELLOW WILL GET TO BE 2399 01:20:05,370 --> 01:20:07,005 EMBEDDED IN THE LAB OF A MENTOR 2400 01:20:07,005 --> 01:20:08,874 TO LEARN THE NEW DISCIPLINE AND 2401 01:20:08,874 --> 01:20:10,042 LITTLE CULTURE. 2402 01:20:10,042 --> 01:20:12,711 AND THEN, WE FIND THAT THERE ARE 2403 01:20:12,711 --> 01:20:14,646 TWO OPPORTUNITIES OR 2 OUTCOMES 2404 01:20:14,646 --> 01:20:16,915 THAT ARE VERY SUCCESSFUL. 2405 01:20:16,915 --> 01:20:18,750 EITHER THIS PERSON GOES AND 2406 01:20:18,750 --> 01:20:19,384 LEARNS SOMETHING NEW AND BRINGS 2407 01:20:19,384 --> 01:20:20,986 IT BACK TO THEIR OLD FIELD, 2408 01:20:20,986 --> 01:20:23,789 WHICH IS A HUGE SUCCESS. 2409 01:20:23,789 --> 01:20:25,590 OR, THE PERSON LEARNS SOMETHING 2410 01:20:25,590 --> 01:20:27,125 NEW AND DECIDES TO PIVOT INTO 2411 01:20:27,125 --> 01:20:30,796 THAT NEW FIELD, AND WHEN THAT 2412 01:20:30,796 --> 01:20:32,431 HAPPENS WE WILL GIVE THE FELLOWS 2413 01:20:32,431 --> 01:20:33,999 AN OPPORTUNITY TO APPLY FOR A 2414 01:20:33,999 --> 01:20:36,001 FULL RESEARCH AWARD IN THE NEW 2415 01:20:36,001 --> 01:20:37,803 FIELD WITHIN ONE YEAR OF THE 2416 01:20:37,803 --> 01:20:39,805 FELLOWSHIP ENDING. 2417 01:20:39,805 --> 01:20:42,707 AND SO, THE APPLICATION FOR THIS 2418 01:20:42,707 --> 01:20:44,910 WILL OPEN MARCH 1 AND THEY WILL 2419 01:20:44,910 --> 01:20:46,711 BE DUE MAY 15 AND YOU CAN FIND 2420 01:20:46,711 --> 01:20:48,480 THAT INFORMATION BY FOLLOWING 2421 01:20:48,480 --> 01:20:52,417 OUR QR CODE. 2422 01:20:52,417 --> 01:20:55,087 OKAY, FINALLY, ANOTHER COMPONENT 2423 01:20:55,087 --> 01:20:59,524 OF NEUROSCIENCE HAPPENING AT THE 2424 01:20:59,524 --> 01:21:00,392 SCIENCE FOUNDATIONING IT OUR 2425 01:21:00,392 --> 01:21:02,594 INTRAMURAL RESEARCH GROUP AT THE 2426 01:21:02,594 --> 01:21:04,162 FLATIRON INSTITUTE. 2427 01:21:04,162 --> 01:21:04,830 THE FLATIRON INSTITUTION MISSION 2428 01:21:04,830 --> 01:21:06,231 IS TO ADVANCE SCIENTIFIC 2429 01:21:06,231 --> 01:21:07,999 RESEARCH THROUGH COMPUTATIONAL 2430 01:21:07,999 --> 01:21:09,501 METHODS, INCLUDING DATA 2431 01:21:09,501 --> 01:21:11,036 ANALYSIS, MODELING AND 2432 01:21:11,036 --> 01:21:12,003 SIMULATION. 2433 01:21:12,003 --> 01:21:13,505 AND WE HAVE FIVE CENTERS. 2434 01:21:13,505 --> 01:21:16,108 THE CENTER FOR COMPUTATIONAL 2435 01:21:16,108 --> 01:21:17,209 ASTROPHYSICS, THE CENTER FOR 2436 01:21:17,209 --> 01:21:18,743 COMPUTATIONAL BIOLOGY, THE 2437 01:21:18,743 --> 01:21:20,412 CENTER FOR COMPUTATIONAL 2438 01:21:20,412 --> 01:21:22,013 MATHEMATICS, CENTER FOR 2439 01:21:22,013 --> 01:21:22,848 COMPUTATIONAL NEUROSCIENCE AND 2440 01:21:22,848 --> 01:21:26,151 THE CENTER FOR COMPUTATIONAL 2441 01:21:26,151 --> 01:21:26,618 QUANTUM PHYSICS. 2442 01:21:26,618 --> 01:21:28,954 THESE ARE ALL SUPPORTED 2443 01:21:28,954 --> 01:21:30,422 SIGNIFICANTLY BY THE SCIENTIFIC 2444 01:21:30,422 --> 01:21:32,824 COMPUTING CORE, WHICH SUPPORTS 2445 01:21:32,824 --> 01:21:34,826 THE INFRASTRUCTURE OR THE 2446 01:21:34,826 --> 01:21:35,827 COMPUTING INFRASTRUCTURE THAT 2447 01:21:35,827 --> 01:21:38,830 BACKS ALL THESE INITIATIVES. 2448 01:21:38,830 --> 01:21:41,133 I'M GOING TO ZOOM IN AND TELL 2449 01:21:41,133 --> 01:21:43,201 YOU GUYS ABOUT THE CENTER FOR 2450 01:21:43,201 --> 01:21:44,169 COMPUTATIONAL NEUROSCIENCE. 2451 01:21:44,169 --> 01:21:46,238 THEIR MISSION IS TO DEVELOP 2452 01:21:46,238 --> 01:21:47,739 MODELS, PRINCIPLES AND 2453 01:21:47,739 --> 01:21:50,041 CONCEPTUAL FRAMEWORKS THAT 2454 01:21:50,041 --> 01:21:51,643 DEEPEN OUR KNOWLEDGE OF BRAIN 2455 01:21:51,643 --> 01:21:53,378 FUNCTION IN HEALTH AND DISEASE. 2456 01:21:53,378 --> 01:21:55,680 THEY TAKE A SYSTEM NEUROSCIENCE 2457 01:21:55,680 --> 01:21:57,249 APPROACH BUILDING MODELS FROM 2458 01:21:57,249 --> 01:21:59,284 EXPERIMENTAL DATA BY CAPTURING 2459 01:21:59,284 --> 01:22:02,220 KEY FEATURES OF NEUROCIRCUITS 2460 01:22:02,220 --> 01:22:03,288 THAT CAN GLEEN INSIGHT INTO 2461 01:22:03,288 --> 01:22:06,758 PERCEPTION, COGNITION, BEHAVIOR. 2462 01:22:06,758 --> 01:22:08,793 THIS APPROACH THEY BELIEVE, IS 2463 01:22:08,793 --> 01:22:11,463 NOT ONLY FOR A ROBUST MODEL 2464 01:22:11,463 --> 01:22:14,399 EXPERIENCE FOR INVESTIGATING 2465 01:22:14,399 --> 01:22:17,369 LARGE AND COMPLEX DATASETS. 2466 01:22:17,369 --> 01:22:19,171 IT ALSO SPURS THE EFFORTS BY THE 2467 01:22:19,171 --> 01:22:21,239 MACHINE LEARNING COMMUNITY TO 2468 01:22:21,239 --> 01:22:23,742 DEVELOP TECHNOLOGY INSPIRED BY 2469 01:22:23,742 --> 01:22:27,579 THE NEUROBIOLOGY OF THE BRAIN. 2470 01:22:27,579 --> 01:22:31,016 AND WE HAVE FOUR PI-LEVEL 2471 01:22:31,016 --> 01:22:32,784 FACULTY WITHIN THE CENTER FOR 2472 01:22:32,784 --> 01:22:34,586 COMPUTATIONAL NEUROSCIENCE. 2473 01:22:34,586 --> 01:22:38,557 OUR TWO SENIOR FACULTY ARE -- [ 2474 01:22:38,557 --> 01:22:39,758 INAUDIBLE ] 2475 01:22:39,758 --> 01:22:42,527 AND OUR TWO MORE JUNIOR FACULTY 2476 01:22:42,527 --> 01:22:43,295 ARE -- [ INAUDIBLE ] 2477 01:22:43,295 --> 01:22:45,697 AND ALL FOUR OF THEM HAVE 2478 01:22:45,697 --> 01:22:46,898 RESEARCH GROUPS THAT ARE BASED 2479 01:22:46,898 --> 01:22:49,401 AT THE FLATIRON INSTITUTE AT THE 2480 01:22:49,401 --> 01:22:57,209 SIMONS FOUNDATION IN NEW YORK. 2481 01:22:57,209 --> 01:22:59,811 THE FINAL NEUROSCIENCE 2482 01:22:59,811 --> 01:23:01,379 INITIATIVE THAT I WANT TO DRAW 2483 01:23:01,379 --> 01:23:04,216 YOUR ATTENTION TO IS CALLED THE 2484 01:23:04,216 --> 01:23:04,516 TRANSMITTER. 2485 01:23:04,516 --> 01:23:06,952 THE TRANSMITTER IS A 2486 01:23:06,952 --> 01:23:08,286 NEWLY-LAUNCHED PUBLICATION 2487 01:23:08,286 --> 01:23:10,121 FOCUSED ON INFORMING 2488 01:23:10,121 --> 01:23:11,623 NEUROSCIENCE ABOUT 2489 01:23:11,623 --> 01:23:13,825 NEUROSCIENTISTS ABOUT NOTEWORTHY 2490 01:23:13,825 --> 01:23:15,961 DEVELOPMENTS ACROSS THE FIELD 2491 01:23:15,961 --> 01:23:16,962 AND ON FORGING CONNECTIONS 2492 01:23:16,962 --> 01:23:19,297 WITHIN THE NEUROSCIENCE 2493 01:23:19,297 --> 01:23:19,798 COMMUNITY. 2494 01:23:19,798 --> 01:23:21,900 THEY ASPIRE TO BECOME ESSENTIAL 2495 01:23:21,900 --> 01:23:23,802 RESOURCE FOR NEUROSCIENTISTS AT 2496 01:23:23,802 --> 01:23:26,972 ALL CAREER STAGES AND TO HELP 2497 01:23:26,972 --> 01:23:29,207 THEM STAY CURRENT AND BUILD 2498 01:23:29,207 --> 01:23:29,507 CONNECTIONS. 2499 01:23:29,507 --> 01:23:31,443 THIS PUBLICATION AIMS TO DELIVER 2500 01:23:31,443 --> 01:23:32,811 INSIGHTS AND TOOLS TO BUILD 2501 01:23:32,811 --> 01:23:35,614 BRIDGES ACROSS NEUROSCIENCE AND 2502 01:23:35,614 --> 01:23:36,147 PROPEL RESEARCH FORWARD. 2503 01:23:36,147 --> 01:23:38,416 AND THEY REALLY THINK THAT 2504 01:23:38,416 --> 01:23:40,719 TRANSMITTERS REFLECTS THEIR 2505 01:23:40,719 --> 01:23:41,019 VISION. 2506 01:23:41,019 --> 01:23:43,021 THEY AIM TO BE FLOURISHING 2507 01:23:43,021 --> 01:23:46,024 COLLABORATIONS AND WHERE THE 2508 01:23:46,024 --> 01:23:49,094 NEUROSCIENCE COMMUNITY WILL BE 2509 01:23:49,094 --> 01:23:51,463 TRANS-- THIS IS OUR COHORT, OUR 2510 01:23:51,463 --> 01:23:53,398 FIRST COHORT OF CONTRIBUTING 2511 01:23:53,398 --> 01:23:53,632 EDITORS. 2512 01:23:53,632 --> 01:23:55,667 THEY ARE A CORE GROUP OF 2513 01:23:55,667 --> 01:23:56,901 ADVISORS FROM DIFFERENT 2514 01:23:56,901 --> 01:23:58,303 SUBFIELDS, FIELDS OF 2515 01:23:58,303 --> 01:23:59,104 NEUROSCIENCE, HELPING TO SHAPE 2516 01:23:59,104 --> 01:24:00,805 THE TRANSMITTER. 2517 01:24:00,805 --> 01:24:03,208 SO I WON'T READ THEIR NAMES BUT 2518 01:24:03,208 --> 01:24:07,979 YOU CAN SEE ALL OF THEM HERE. 2519 01:24:07,979 --> 01:24:10,982 AND THEY HAVE FOCUS INITIALLY ON 2520 01:24:10,982 --> 01:24:13,184 INCLUDING MORE REGULAR SCIENTIST 2521 01:24:13,184 --> 01:24:14,185 WRITTEN MATERIAL IN THIS 2522 01:24:14,185 --> 01:24:15,220 PUBLICATION AND THEY ARE DOING 2523 01:24:15,220 --> 01:24:17,188 THIS IN MULTIPLE FORMS. 2524 01:24:17,188 --> 01:24:20,425 NOT JUST OPINION STORIES. 2525 01:24:20,425 --> 01:24:23,128 THEY ARE LAUNCHING THINGS LIKE 2526 01:24:23,128 --> 01:24:25,997 SCIENTIST WRITTEN ESSAYS AND 2527 01:24:25,997 --> 01:24:27,999 DATA SHARING ESSAYS WHICH 2528 01:24:27,999 --> 01:24:29,100 EXPLORES THE BENEFITS AND 2529 01:24:29,100 --> 01:24:30,502 CHALLENGES OF DATA SHARING AND 2530 01:24:30,502 --> 01:24:32,604 THEY ALSO HAVE REOCCURRING 2531 01:24:32,604 --> 01:24:34,005 COLUMNS SUCH AS HOW TO TEACH 2532 01:24:34,005 --> 01:24:35,807 THIS PAPER, WHICH IS A SERIES 2533 01:24:35,807 --> 01:24:38,410 THAT GUIDES EDUCATORS AND SELF 2534 01:24:38,410 --> 01:24:41,913 LEARNERS THROUGH RESEARCH 2535 01:24:41,913 --> 01:24:43,014 NEUROSCIENCE PAPERS. 2536 01:24:43,014 --> 01:24:45,317 THEY HAVE A PODCAST CALLED 2537 01:24:45,317 --> 01:24:47,919 SYNAPTIC, WHICH IS EXPLORING THE 2538 01:24:47,919 --> 01:24:48,653 PEOPLE, THE SCIENCE DID THE 2539 01:24:48,653 --> 01:24:51,956 CHALLENGES IN NEUROSCIENCE. 2540 01:24:51,956 --> 01:24:53,525 ALSO SOME OF THE MOST READ 2541 01:24:53,525 --> 01:24:56,328 FEATURES SO FAR INCLUDE, MAKING 2542 01:24:56,328 --> 01:24:59,230 CANCER NERVOUS AND WHAT DRIFTING 2543 01:24:59,230 --> 01:25:00,732 REPRESENTATIONS REVEAL ABOUT THE 2544 01:25:00,732 --> 01:25:01,333 BRAIN. 2545 01:25:01,333 --> 01:25:03,134 SO I ENCOURAGE ALL OF YOU TO 2546 01:25:03,134 --> 01:25:04,135 VISIT THE TRANSMITTER. 2547 01:25:04,135 --> 01:25:06,705 YOU CAN DO SO BY FOLLOWING THIS 2548 01:25:06,705 --> 01:25:08,139 QR CODE AND IF YOU'RE INTERESTED 2549 01:25:08,139 --> 01:25:14,312 IN BECOMING A -- EXPERT 2550 01:25:14,312 --> 01:25:15,613 CONTRIBUTESSOR, PLEASE REACH OUT 2551 01:25:15,613 --> 01:25:20,318 AND CONTACT THEM HERE. 2552 01:25:20,318 --> 01:25:23,922 SO THANK YOU VERY MUCH FOR YOUR 2553 01:25:23,922 --> 01:25:24,856 ATTENTION AND THE OPPORTUNITY TO 2554 01:25:24,856 --> 01:25:27,892 TELL YOU ABOUT THE NEUROSCIENCE 2555 01:25:27,892 --> 01:25:33,765 GOING - AT THE SIMONS FOUNDA 2556 01:25:33,765 --> 01:25:34,733 FOUNDATION. 2557 01:25:34,733 --> 01:25:37,435 >> THANK YOU THAT WAS A TERRIFIC 2558 01:25:37,435 --> 01:25:38,336 PRESENTATION AND IT'S EXCITING 2559 01:25:38,336 --> 01:25:40,238 TO HEAR ABOUT ALL OF THE 2560 01:25:40,238 --> 01:25:42,741 DIFFERENT PROGRAMS THAT YOU HAVE 2561 01:25:42,741 --> 01:25:44,509 TARGETING VERY DIFFERENT GROUPS 2562 01:25:44,509 --> 01:25:45,744 AND I WAS ALSO PARTICULARLY 2563 01:25:45,744 --> 01:25:46,945 INTERESTED IN THE LAST BIT THAT 2564 01:25:46,945 --> 01:25:48,613 YOU TALKED ABOUT WITH THE 2565 01:25:48,613 --> 01:25:49,547 TRANSMITTER BECAUSE I THINK 2566 01:25:49,547 --> 01:25:51,349 THOSE ARE SUCH CRITICAL ASPECTS 2567 01:25:51,349 --> 01:25:54,152 TO WHAT WE DO AND TO HAVE 2568 01:25:54,152 --> 01:25:54,519 IMPACT. 2569 01:25:54,519 --> 01:25:56,721 SO APPRECIATE IT AND I WILL 2570 01:25:56,721 --> 01:25:59,524 DEFINITELY LOOK AT IT. 2571 01:25:59,524 --> 01:26:00,725 SO THANK YOU. 2572 01:26:00,725 --> 01:26:08,600 ARE THERE QUESTIONS, COMMENTS? 2573 01:26:08,600 --> 01:26:09,834 >> THAT WAS A GREAT OVERVIEW OF 2574 01:26:09,834 --> 01:26:11,803 WHAT THE FOUNDATION IS DOING. 2575 01:26:11,803 --> 01:26:14,372 IT'S GRATIFYING TO SEE HOW THE 2576 01:26:14,372 --> 01:26:15,840 DIFFERENT PARTNERS CAN REALLY 2577 01:26:15,840 --> 01:26:17,675 CONTRIBUTE TO THE ECOSYSTEM IN 2578 01:26:17,675 --> 01:26:18,743 SUCH A INTERESTING WAY. 2579 01:26:18,743 --> 01:26:20,645 I MEAN, WE'RE AWARE OF WHAT EACH 2580 01:26:20,645 --> 01:26:21,980 OTHER IS DOING BUT IT'S NOT LIKE 2581 01:26:21,980 --> 01:26:23,548 WE ARE NECESSARILY PLANNING 2582 01:26:23,548 --> 01:26:24,749 THESE THINGS OUT, PER SE WHEN 2583 01:26:24,749 --> 01:26:26,684 NOBODY IS TELLING EACH OTHER TO 2584 01:26:26,684 --> 01:26:28,787 DO OR NOT TO DO BUT IT'S 2585 01:26:28,787 --> 01:26:30,455 REMARKABLE HOW WE CAN FIND THESE 2586 01:26:30,455 --> 01:26:32,157 NATURALLY GOOD FITS AND REALLY 2587 01:26:32,157 --> 01:26:34,459 LIFT THE ENTIRE FIELD BY 2588 01:26:34,459 --> 01:26:37,462 CONTRIBUTING IN THESE DIFFERENT 2589 01:26:37,462 --> 01:26:37,695 DOMAINS. 2590 01:26:37,695 --> 01:26:38,363 >> THANK YOU VERY MUCH. 2591 01:26:38,363 --> 01:26:42,567 I VERY MUCH AGREE THE WAYS WE 2592 01:26:42,567 --> 01:26:45,270 WORK TOGETHER HAVE BEEN REALLY 2593 01:26:45,270 --> 01:26:49,574 GRATIFYING. 2594 01:26:49,574 --> 01:26:50,208 >> FRANK? 2595 01:26:50,208 --> 01:26:51,276 >> ALYSSA, GREAT PRESENTATION 2596 01:26:51,276 --> 01:26:53,578 AND FOR THE FIRST PART OF THE 2597 01:26:53,578 --> 01:26:54,913 PRESENTATION SO IMPRESSED BY ALL 2598 01:26:54,913 --> 01:26:57,816 OF THESE LAYERS OF OMICS AND 2599 01:26:57,816 --> 01:26:59,384 INFORMATION OF AUTISM. 2600 01:26:59,384 --> 01:27:04,055 AND I'M WONDERING AUTISM IS A 2601 01:27:04,055 --> 01:27:05,590 TRICKY AREA BECAUSE THERE ARE 2602 01:27:05,590 --> 01:27:06,491 MANY DIFFERENT KINDS. 2603 01:27:06,491 --> 01:27:08,293 THAT'S A CONTEXT OF ANY 2604 01:27:08,293 --> 01:27:08,560 QUESTIONS. 2605 01:27:08,560 --> 01:27:09,727 TO WHAT EXTENT YOUR PROGRAMS 2606 01:27:09,727 --> 01:27:14,165 HAVE BEEN INVOLVED IN CANDIDATE 2607 01:27:14,165 --> 01:27:15,767 THERAPEUTIC TARGETS OR 2608 01:27:15,767 --> 01:27:17,869 MECHANISMS AND TO WHAT EXTENT 2609 01:27:17,869 --> 01:27:19,704 HAVE THOSE BEEN HARNESSED BY 2610 01:27:19,704 --> 01:27:23,007 EITHER ACADEMICS OR INDUSTRY AND 2611 01:27:23,007 --> 01:27:24,375 CANDIDATE THERAPEUTICS CREATED 2612 01:27:24,375 --> 01:27:25,410 OR TESTED. 2613 01:27:25,410 --> 01:27:29,481 I MEAN, IS IT TOO EARLY FOR 2614 01:27:29,481 --> 01:27:29,948 THAT? 2615 01:27:29,948 --> 01:27:31,282 HOW DOES THAT FIT? 2616 01:27:31,282 --> 01:27:33,485 >> SO I WILL SAY FIRST OF ALL 2617 01:27:33,485 --> 01:27:35,787 THAT SAFARI IS NOT MY MAIN 2618 01:27:35,787 --> 01:27:35,987 FOCUS. 2619 01:27:35,987 --> 01:27:37,822 SO I CAN ANSWER ON A GENERAL 2620 01:27:37,822 --> 01:27:40,325 LEVEL AND REFER YOU TO FOR 2621 01:27:40,325 --> 01:27:42,827 EXAMPLE, KELSEY MARTIN WHO 2622 01:27:42,827 --> 01:27:44,596 OVERSEES THE AUTISM AND 2623 01:27:44,596 --> 01:27:46,030 NEUROSCIENCE DIVISION FOR A MORE 2624 01:27:46,030 --> 01:27:46,598 DETAILED ANSWER. 2625 01:27:46,598 --> 01:27:48,900 WE ARE VERY FOCUSED ON THE BASIC 2626 01:27:48,900 --> 01:27:51,736 SCIENCE UNDERLYING AUTISM AND 2627 01:27:51,736 --> 01:27:54,606 SO, WE HAVE NOT BEEN DIRECTLY 2628 01:27:54,606 --> 01:27:57,108 INVOLVED WITH GENERATING 2629 01:27:57,108 --> 01:27:58,776 THERAPEUTICS BUT I KNOW THAT 2630 01:27:58,776 --> 01:28:00,411 IT'S A HOPE COMING OUT OF THIS 2631 01:28:00,411 --> 01:28:00,778 WORK. 2632 01:28:00,778 --> 01:28:03,781 AND I WILL DEFER YOU TO KELSEY 2633 01:28:03,781 --> 01:28:05,517 FOR MORE DETAILED ANSWER TO THAT 2634 01:28:05,517 --> 01:28:05,984 QUESTION. 2635 01:28:05,984 --> 01:28:07,886 >> YES, THANK YOU. 2636 01:28:07,886 --> 01:28:11,723 AND CONCEPTUALLY, I HAVE ALWAYS 2637 01:28:11,723 --> 01:28:14,692 WONDERED FOR EFFORTS THAT 2638 01:28:14,692 --> 01:28:16,094 PRIORITIZE BASIC MECHANISM 2639 01:28:16,094 --> 01:28:19,397 ELUCIDATION WHICH IS A CRITICAL 2640 01:28:19,397 --> 01:28:22,400 BEDROCK, TO WHAT EXTENT DOES 2641 01:28:22,400 --> 01:28:23,902 ATTEMPTING THERAPEUTICS HELP THE 2642 01:28:23,902 --> 01:28:25,503 BASIC PROCESS IN TERMS OF A FEED 2643 01:28:25,503 --> 01:28:27,906 BACK LOOP OF REALITY, RIGHT? 2644 01:28:27,906 --> 01:28:30,208 OUR CONSTRUCT OF A BASIC 2645 01:28:30,208 --> 01:28:33,645 MECHANISM CAN BE TESTED BY A 2646 01:28:33,645 --> 01:28:35,413 THERAPEUTIC ATTEMPT AND DOES 2647 01:28:35,413 --> 01:28:37,916 THAT STILL -- IS THAT STILL PART 2648 01:28:37,916 --> 01:28:38,816 OF THE BASIC RESEARCH IS MAKING 2649 01:28:38,816 --> 01:28:39,317 THAT ATTEMPT? 2650 01:28:39,317 --> 01:28:40,618 I THINK THERE IS A WIDE VIEW OF 2651 01:28:40,618 --> 01:28:42,420 OPINIONS ON THAT. 2652 01:28:42,420 --> 01:28:44,422 SOME WILL SAY THE THERAPEUTIC 2653 01:28:44,422 --> 01:28:46,591 ATTEMPT IS PREMATURE, DON'T 2654 01:28:46,591 --> 01:28:47,325 WASTE RESOURCES OR TIME. 2655 01:28:47,325 --> 01:28:50,194 I HAVE TO ADMIT MY BIAS IS, 2656 01:28:50,194 --> 01:28:51,930 THOSE ATTEMPTS HELP INFORM OUR 2657 01:28:51,930 --> 01:28:53,498 BASIC CONSTRUCTS OF WHETHER THEY 2658 01:28:53,498 --> 01:28:55,333 ARE RIGHT OR WRONG. 2659 01:28:55,333 --> 01:28:58,636 SO IT'S AN INTERESTING AREA FOR 2660 01:28:58,636 --> 01:28:58,803 ME. 2661 01:28:58,803 --> 01:29:00,672 >> I MEAN I THINK THOSE ARE ALL 2662 01:29:00,672 --> 01:29:02,240 VERY GOOD POINTS AND I THINK 2663 01:29:02,240 --> 01:29:05,410 THESE ARE THINGS WE ARE THINKING 2664 01:29:05,410 --> 01:29:07,912 DEEPLY ABOUT AND RIGHT NOW WE 2665 01:29:07,912 --> 01:29:09,847 ARE IN THE MIDDLE OF A DEEP 2666 01:29:09,847 --> 01:29:12,216 STRATEGIC PLAN ABOUT HOW WE ARE 2667 01:29:12,216 --> 01:29:14,419 MOVING FORWARD IN SAFARI AND THE 2668 01:29:14,419 --> 01:29:15,720 NEUROSCIENCE COLLABORATIONS BUT 2669 01:29:15,720 --> 01:29:17,922 MAINLY FOCUSED ON SAFARI AND SO, 2670 01:29:17,922 --> 01:29:20,525 I'M GOING TO WITH HOLD ON 2671 01:29:20,525 --> 01:29:21,626 ACTUALLY ANSWERING THAT QUESTION 2672 01:29:21,626 --> 01:29:22,827 BECAUSE THAT'S THE QUESTION WE 2673 01:29:22,827 --> 01:29:24,329 ARE STRUGGLING WITH. 2674 01:29:24,329 --> 01:29:24,762 >> SURE. 2675 01:29:24,762 --> 01:29:26,531 HAPPY TO CONTRIBUTE TO THAT IF 2676 01:29:26,531 --> 01:29:27,298 THAT'S HELPFUL. 2677 01:29:27,298 --> 01:29:32,437 THANK YOU. 2678 01:29:32,437 --> 01:29:32,737 >> SAMEER. 2679 01:29:32,737 --> 01:29:33,104 >> THANK YOU. 2680 01:29:33,104 --> 01:29:37,442 THAT WAS REALLY INSPIRING. 2681 01:29:37,442 --> 01:29:40,244 KIND OF LIKE FRANK'S QUESTION 2682 01:29:40,244 --> 01:29:43,047 MAYBE AND ALSO SORT OF WHAT JOHN 2683 01:29:43,047 --> 01:29:45,750 WAS MENTIONING THE OPPOSITE, THE 2684 01:29:45,750 --> 01:29:47,118 RELATIONSHIP BETWEEN WHAT THE 2685 01:29:47,118 --> 01:29:48,119 SIMONS FOUNDATION IS DOING AND 2686 01:29:48,119 --> 01:29:49,520 WHAT THE BRAIN INITIATIVE IS 2687 01:29:49,520 --> 01:29:51,422 DOING IN FUNDING, RIGHT? 2688 01:29:51,422 --> 01:29:53,224 SO JOHN SAID WE ARE AWARE OF 2689 01:29:53,224 --> 01:29:53,858 EACH OTHER. 2690 01:29:53,858 --> 01:29:55,927 SO I GUESS THE QUESTION -- IT'S 2691 01:29:55,927 --> 01:29:57,528 A PHILOSOPHICAL QUESTION AND 2692 01:29:57,528 --> 01:29:59,163 MAYBE A NAIVE ONE, I DON'T KNOW. 2693 01:29:59,163 --> 01:30:03,167 WHAT DOES SIMON FOUNDATION THINK 2694 01:30:03,167 --> 01:30:04,569 ABOUT WHAT NIH MAYBE MORE 2695 01:30:04,569 --> 01:30:06,537 SPECIFIC BRAIN, IS DOING IN 2696 01:30:06,537 --> 01:30:07,372 SIMILAR SPACES? 2697 01:30:07,372 --> 01:30:11,175 IS THERE A DESIRE TO KEEP 2698 01:30:11,175 --> 01:30:13,177 CLOSER, KEEP FURTHER AWAY? 2699 01:30:13,177 --> 01:30:16,581 DO YOUR OWN THING AND KIND OF AG 2700 01:30:16,581 --> 01:30:18,850 NOSTICALLY WORKING IN RELATION 2701 01:30:18,850 --> 01:30:22,253 TO WHAT THE FEDERAL GOVERNMENT 2702 01:30:22,253 --> 01:30:24,989 IS DOING? 2703 01:30:24,989 --> 01:30:26,491 -- 2704 01:30:26,491 --> 01:30:26,891 >> ABSOLUTELY. 2705 01:30:26,891 --> 01:30:29,460 I MEAN I THINK IT'S A GREAT 2706 01:30:29,460 --> 01:30:30,561 QUESTION AND I THINK THAT WE -- 2707 01:30:30,561 --> 01:30:33,231 ONE OF THE REASONS WE INTERACT 2708 01:30:33,231 --> 01:30:34,399 WITH THE FEDERAL GOVERNMENT IS 2709 01:30:34,399 --> 01:30:35,767 SO THAT WE DON'T DUPLICATE 2710 01:30:35,767 --> 01:30:38,236 EFFORT AND OUR EFFORTS CAN BE 2711 01:30:38,236 --> 01:30:38,836 SYNERGISTIC. 2712 01:30:38,836 --> 01:30:41,873 AND SO, I THINK THAT THE NIH AND 2713 01:30:41,873 --> 01:30:44,042 THE BRAIN INITIATIVE HAVE A 2714 01:30:44,042 --> 01:30:45,276 CENTRAL ROLE IN THIS ECOSYSTEM 2715 01:30:45,276 --> 01:30:47,378 AND WE HOPE THE SIMONS 2716 01:30:47,378 --> 01:30:48,680 FOUNDATION ROLE WILL BE 2717 01:30:48,680 --> 01:30:49,580 COMPLEMENTARY RATHER THAN 2718 01:30:49,580 --> 01:30:49,881 OVERLAPPING. 2719 01:30:49,881 --> 01:30:51,883 AND SO IN THOSE WAYS WE CAN WORK 2720 01:30:51,883 --> 01:30:54,252 TOGETHER AND PARTNER. 2721 01:30:54,252 --> 01:30:56,154 AND SO, THOSE ARE A LOT OF THE 2722 01:30:56,154 --> 01:30:57,188 THINGS WE ARE THINKING ABOUT AS 2723 01:30:57,188 --> 01:30:58,823 WE ARE THINKING ABOUT THE FUTURE 2724 01:30:58,823 --> 01:31:00,692 OF SAFARI AND THINKING ABOUT THE 2725 01:31:00,692 --> 01:31:02,460 NEXT STEPS OF THE NEUROSCIENCE 2726 01:31:02,460 --> 01:31:03,428 COLLABORATIONS AND WHAT WE ARE 2727 01:31:03,428 --> 01:31:05,463 GOING TO INVEST IN, WHAT THINGS 2728 01:31:05,463 --> 01:31:07,765 ARE BEING INVESTED BY THE BRAIN 2729 01:31:07,765 --> 01:31:08,066 INITIATIVE. 2730 01:31:08,066 --> 01:31:10,868 WHERE CAN WE MAKE A UNIQUE AND 2731 01:31:10,868 --> 01:31:12,103 COMPLEMENTARY IMPACT. 2732 01:31:12,103 --> 01:31:14,472 >> IF I COULD JUST JUMP IN. 2733 01:31:14,472 --> 01:31:17,175 I MEAN, IT'S ABOUT -- I THINK 2734 01:31:17,175 --> 01:31:20,178 IT'S ABOUT FINDING BOLD IDEAS 2735 01:31:20,178 --> 01:31:25,083 FOR THE FUTURE AND THEN HAVING 2736 01:31:25,083 --> 01:31:25,883 PEOPLE WITH CREATIVE IDEAS COME 2737 01:31:25,883 --> 01:31:28,786 IN AND SUPPORTING THEM. 2738 01:31:28,786 --> 01:31:30,455 SO ALYSSA, I REALLY APPRECIATE 2739 01:31:30,455 --> 01:31:33,624 THE FOUNDATION'S INTEREST IN 2740 01:31:33,624 --> 01:31:35,793 DEVELOPING A MORE DIVERSE 2741 01:31:35,793 --> 01:31:36,694 SELECTIVELY INVESTIGATOR BASE 2742 01:31:36,694 --> 01:31:37,995 THAT WILL HELP. 2743 01:31:37,995 --> 01:31:42,100 THE OTHER REALITY IS THAT IF YOU 2744 01:31:42,100 --> 01:31:43,401 LOOK AT THE FOLKS THAT THE 2745 01:31:43,401 --> 01:31:44,602 FOUNDATION FUNDS OR HAS FUNDED 2746 01:31:44,602 --> 01:31:46,571 AND THE FOLKS THAT RECEIVE 2747 01:31:46,571 --> 01:31:50,608 ROBUST FUNDING FOR BRAIN, IT'S A 2748 01:31:50,608 --> 01:31:50,842 DIAGRAM. 2749 01:31:50,842 --> 01:31:53,211 THERE IS A LOT OF SYNERGY THERE. 2750 01:31:53,211 --> 01:31:54,746 IT'S NOT DUPLICATIVE FUNDING. 2751 01:31:54,746 --> 01:31:56,080 I THINK WHAT YOU'RE SAYING IS 2752 01:31:56,080 --> 01:31:59,817 ANY PROJECT FROM CONCEPT TO 2753 01:31:59,817 --> 01:32:00,785 EXECUTION TO WHATEVER YOU MIGHT 2754 01:32:00,785 --> 01:32:04,055 THINK OF AS A CAPSTONE PROJECT 2755 01:32:04,055 --> 01:32:08,893 OR INCLUSION, OCCURS IN PHASES. 2756 01:32:08,893 --> 01:32:10,394 THAT'S A BIT TONE LOGIC WHAT I 2757 01:32:10,394 --> 01:32:11,095 JUST SAID. 2758 01:32:11,095 --> 01:32:13,030 AND DIFFERENT FUNDERS HAVE 2759 01:32:13,030 --> 01:32:14,132 DIFFERENT FUNDING OPPORTUNITIES 2760 01:32:14,132 --> 01:32:15,900 AND PLAY ROLES AT THESE 2761 01:32:15,900 --> 01:32:17,902 DIFFERENT STAGES OF THE PROJECT. 2762 01:32:17,902 --> 01:32:19,370 SO DIFFERENT MECHANISMS ARE 2763 01:32:19,370 --> 01:32:21,405 FUNDING WILL WORK IN SOME AREAS 2764 01:32:21,405 --> 01:32:23,207 BETTER AND NOT SO PERFECTLY IN 2765 01:32:23,207 --> 01:32:23,441 OTHERS. 2766 01:32:23,441 --> 01:32:25,209 AND I THINK THE REALLY COOL 2767 01:32:25,209 --> 01:32:26,511 THING IS THAT THE FOUNDATION, 2768 01:32:26,511 --> 01:32:28,312 OTHER FOUNDATIONS IN THIS SPACE, 2769 01:32:28,312 --> 01:32:30,047 AND THE NIH SUMMERY, ARE DOING 2770 01:32:30,047 --> 01:32:31,616 THE BEST TO LIFT THE ENTIRE 2771 01:32:31,616 --> 01:32:31,883 FIELD. 2772 01:32:31,883 --> 01:32:33,217 AND I THINK THAT IS WHAT IS 2773 01:32:33,217 --> 01:32:34,652 REALLY IMPORTANT AND TO BRING 2774 01:32:34,652 --> 01:32:35,820 NEW PEOPLE AND NEW IDEAS INTO 2775 01:32:35,820 --> 01:32:36,454 THE FIELD. 2776 01:32:36,454 --> 01:32:37,088 IT'S WORKED OUT. 2777 01:32:37,088 --> 01:32:41,259 NOT LIKE WE ARE NOT GOATS. 2778 01:32:41,259 --> 01:32:42,994 WE'RE NOT CONSPIRING IN ANY WAY. 2779 01:32:42,994 --> 01:32:45,630 I THINK THERE IS A COMMON SET OF 2780 01:32:45,630 --> 01:32:47,965 THINKERS BEHIND ALL OF THIS AND 2781 01:32:47,965 --> 01:32:50,701 I THINK THE KEY IS NOT TO HAVE 2782 01:32:50,701 --> 01:32:53,805 IT BE TOO IMBRED BUT TO BE 2783 01:32:53,805 --> 01:32:55,606 CONSTANTLY BRINGING IN NEW IDEAS 2784 01:32:55,606 --> 01:32:58,576 AND ENLIST THE ENTIRE FIELD AND 2785 01:32:58,576 --> 01:32:59,977 TO THE EXTENT THESE RESOURCES 2786 01:32:59,977 --> 01:33:02,647 ARE DISSEMINATED BROADLY, 2787 01:33:02,647 --> 01:33:03,080 EVERYBODY BENEFITS. 2788 01:33:03,080 --> 01:33:03,614 WE DEFINITELY WANT TO BE 2789 01:33:03,614 --> 01:33:04,515 WATCHING THIS. 2790 01:33:04,515 --> 01:33:08,386 THIS IS ONE REASON WHY WE 2791 01:33:08,386 --> 01:33:09,020 INDIVIDUAL BRAIN INITIATIVE SO 2792 01:33:09,020 --> 01:33:11,355 WE CAN TALK TO EACH OTHER. 2793 01:33:11,355 --> 01:33:13,624 THIS IS ONE REASON WHY WE 2794 01:33:13,624 --> 01:33:15,793 CREATED THE EX OFFICIO POSITION 2795 01:33:15,793 --> 01:33:17,528 FOR THE NON FEDERAL CO-CHAIR TO 2796 01:33:17,528 --> 01:33:18,763 MAKE SURE WE ARE AWARE OF WHAT 2797 01:33:18,763 --> 01:33:21,132 IS GOING ON AND TO SEE WHERE WE 2798 01:33:21,132 --> 01:33:22,733 CAN HELP NOT JUST EACH OTHER BUT 2799 01:33:22,733 --> 01:33:24,635 REALLY HELP THE FIELD IN 2800 01:33:24,635 --> 01:33:25,536 COMPLEMENTARY WAYS. 2801 01:33:25,536 --> 01:33:28,039 I'LL GET OFF MY SOAPBOX BUT 2802 01:33:28,039 --> 01:33:30,208 THANKS FOR THE COMMENTS. 2803 01:33:30,208 --> 01:33:32,910 >> THANK YOU. 2804 01:33:32,910 --> 01:33:37,415 >> ABSOLUTELY. 2805 01:33:37,415 --> 01:33:37,882 >> THANK YOU. 2806 01:33:37,882 --> 01:33:40,451 IT WAS REALLY INTERESTING TO 2807 01:33:40,451 --> 01:33:42,420 HEAR THE BACKGROUND SUMMARY OF 2808 01:33:42,420 --> 01:33:43,554 WHAT THE SIMON FOUNDATION IS 2809 01:33:43,554 --> 01:33:44,155 DOING NOW. 2810 01:33:44,155 --> 01:33:46,657 MY QUESTION IS SORT OF A GENERAL 2811 01:33:46,657 --> 01:33:48,359 ENVIRONMENTAL QUESTION AND IT'S 2812 01:33:48,359 --> 01:33:50,561 THAT ONE OF THE MAJOR STRAINS OF 2813 01:33:50,561 --> 01:33:52,763 SPARK HAS BEEN THE COMPTATIONAL 2814 01:33:52,763 --> 01:33:54,432 COMPONENTS OF IT, THE WAY OF 2815 01:33:54,432 --> 01:33:58,035 DOING GWAS ANALYSIS, GENE 2816 01:33:58,035 --> 01:33:59,737 DISCOVERY AND THE FIELDS ACROSS 2817 01:33:59,737 --> 01:34:01,739 DIFFERENT KINDS OF DISEASE 2818 01:34:01,739 --> 01:34:02,039 STATES. 2819 01:34:02,039 --> 01:34:03,908 SO NOW WITH THE FLATIRON 2820 01:34:03,908 --> 01:34:04,842 INSTITUTE WHERE YOU HAVE 2821 01:34:04,842 --> 01:34:06,477 MULTIPLE DIFFERENT 2822 01:34:06,477 --> 01:34:08,679 BIOCOMPTATIONAL GROUPS, HOW DO 2823 01:34:08,679 --> 01:34:09,513 THEY INTERACT? 2824 01:34:09,513 --> 01:34:12,950 I THINK THE SYNERGISM AND 2825 01:34:12,950 --> 01:34:13,584 CREATIVITY COULD BE CREATED 2826 01:34:13,584 --> 01:34:15,253 THROUGH THAT TYPE OF INTERACTION 2827 01:34:15,253 --> 01:34:18,256 LOOKING AT DIFFERENT TYPES OF 2828 01:34:18,256 --> 01:34:20,558 DATASETS MIGHT BE REALLY -- 2829 01:34:20,558 --> 01:34:23,261 CERTAINLY THE BRAIN INITIATIVE 2830 01:34:23,261 --> 01:34:24,896 CLEARLY ADDRESSES IN THE STORAGE 2831 01:34:24,896 --> 01:34:26,063 AND CAN POTENTIALLY LEARN ABOUT 2832 01:34:26,063 --> 01:34:27,665 HOW TO THINK ABOUT THAT 2833 01:34:27,665 --> 01:34:30,167 SYNERGISM AND CREATIVITY. 2834 01:34:30,167 --> 01:34:30,868 >> YES, ABSOLUTELY. 2835 01:34:30,868 --> 01:34:32,770 I FULLY AGREE. 2836 01:34:32,770 --> 01:34:35,339 AND ONE OF THE SIMONS 2837 01:34:35,339 --> 01:34:37,275 FOUNDATION, JIM SIMONS IS A 2838 01:34:37,275 --> 01:34:38,276 MATHEMATICIAN BY TRAINING WHICH 2839 01:34:38,276 --> 01:34:40,912 HAS DRIVEN A LOT OF OUR INITIAL 2840 01:34:40,912 --> 01:34:42,213 INVESTMENTS IN COMPUTATIONAL 2841 01:34:42,213 --> 01:34:42,480 WORK. 2842 01:34:42,480 --> 01:34:44,582 AND THE FLATIRON INSTITUTE AND 2843 01:34:44,582 --> 01:34:46,217 THE SIMONS FOUNDATION ARE 2844 01:34:46,217 --> 01:34:48,686 CO-LOCATED ON 21st AND 2845 01:34:48,686 --> 01:34:49,553 5th IN NEW YORK CITY AND WE 2846 01:34:49,553 --> 01:34:52,757 HAVE A VERY IN-PERSON MILL YOW 2847 01:34:52,757 --> 01:34:54,792 AND A LOT OF SCIENTIFIC 2848 01:34:54,792 --> 01:34:55,059 EXCHANGE. 2849 01:34:55,059 --> 01:34:56,394 THEIR WORK IS CONSTANTLY 2850 01:34:56,394 --> 01:34:57,762 INFLUENCING HOW WE THINK ABOUT 2851 01:34:57,762 --> 01:34:59,597 THINGS, HOW WE THINK ABOUT 2852 01:34:59,597 --> 01:35:00,598 THINGS AND THE CONNECTIONS WE 2853 01:35:00,598 --> 01:35:03,668 CAN MAKE BOTH ON THE OUTWARD 2854 01:35:03,668 --> 01:35:05,102 FUNDING SIDE AND IN HOUSE 2855 01:35:05,102 --> 01:35:06,203 COMPUTATIONAL SIDE ARE SOMETHING 2856 01:35:06,203 --> 01:35:09,573 WE ARE CONTINUALLY TRYING TO 2857 01:35:09,573 --> 01:35:13,577 FACILITATE AND FOSTER AND SO I 2858 01:35:13,577 --> 01:35:16,380 THINK JUST CONTINUING TO HAVE AN 2859 01:35:16,380 --> 01:35:17,782 EYE TOWARD HOW THE COMPUTATIONAL 2860 01:35:17,782 --> 01:35:21,252 ARM AND THEORETICAL CAN 2861 01:35:21,252 --> 01:35:22,053 INTERSECT WITH THE EXPERIMENTAL 2862 01:35:22,053 --> 01:35:23,187 AND BIOLOGICAL PORTIONS OF 2863 01:35:23,187 --> 01:35:24,889 SCIENCE IS SOMETHING THAT IS 2864 01:35:24,889 --> 01:35:27,058 REALLY IN THE ETHOS OF THE 2865 01:35:27,058 --> 01:35:28,059 SCIENCE FOUNDATION AND REWILL 2866 01:35:28,059 --> 01:35:31,095 CONTINUE TO DO. 2867 01:35:31,095 --> 01:35:32,296 >> JUST A QUICK FOLLOW-UP AND 2868 01:35:32,296 --> 01:35:33,898 I'LL TURN IT OVER. 2869 01:35:33,898 --> 01:35:36,634 SORT OF WONDERING ABOUT THE 2870 01:35:36,634 --> 01:35:38,602 DIFFERENT WAYS OF LOOKING AT THE 2871 01:35:38,602 --> 01:35:38,903 DATASET. 2872 01:35:38,903 --> 01:35:40,504 SO BETWEEN THE DIFFERENT GROUPS 2873 01:35:40,504 --> 01:35:50,014 YOU HAVE AT THE FLATIRON. 2874 01:35:50,014 --> 01:35:51,115 AND THINKING ABOUT HOW TO MAKE 2875 01:35:51,115 --> 01:35:53,718 THAT GENERALLY APPLICABLE IS AN 2876 01:35:53,718 --> 01:35:55,486 OPPORTUNITY THAT DOESN'T REALLY 2877 01:35:55,486 --> 01:35:56,620 EXIST IN MANY PLACES. 2878 01:35:56,620 --> 01:35:57,722 >> I ABSOLUTELY AGREE. 2879 01:35:57,722 --> 01:35:59,924 WE HAVE PEOPLE FROM THE CENTER 2880 01:35:59,924 --> 01:36:01,692 FOR COMPUTATIONAL MATHEMATICS 2881 01:36:01,692 --> 01:36:03,361 COLLABORATING DEEPLY WITH PEOPLE 2882 01:36:03,361 --> 01:36:04,128 IN THE CENTER FOR COMPUTATIONAL 2883 01:36:04,128 --> 01:36:06,397 BIOLOGY AND THE CENTER FOR FOR 2884 01:36:06,397 --> 01:36:07,898 COMPUTATIONAL NEUROSCIENCE AND 2885 01:36:07,898 --> 01:36:10,301 THE PENCIL THEORIES 2886 01:36:10,301 --> 01:36:13,070 COLLABORATING WITH OTHERS. 2887 01:36:13,070 --> 01:36:15,473 ALL WITHIN THE FLATIRON 2888 01:36:15,473 --> 01:36:17,174 INSTITUTE AND THEN ATTENDING 2889 01:36:17,174 --> 01:36:18,609 MEETINGS AT SAFARI AND 2890 01:36:18,609 --> 01:36:19,777 UNDERSTANDING WHAT IS GOING ON 2891 01:36:19,777 --> 01:36:21,512 IN THE NEUROSCIENCE 2892 01:36:21,512 --> 01:36:21,879 COLLABORATIONS. 2893 01:36:21,879 --> 01:36:24,915 SO I ABSOLUTELY AGREE WITH YOU. 2894 01:36:24,915 --> 01:36:26,851 I AM SURE THERE ARE MORE WAYS WE 2895 01:36:26,851 --> 01:36:29,353 CAN BE DOING THIS BUT 2896 01:36:29,353 --> 01:36:31,922 FACILITATING COLLABORATIONS AND 2897 01:36:31,922 --> 01:36:33,791 DIFFERENT LENSES ON THE DATA IS 2898 01:36:33,791 --> 01:36:38,529 ABSOLUTELY ON OUR MINDS. 2899 01:36:38,529 --> 01:36:39,030 >> GREAT PRESENTATION. 2900 01:36:39,030 --> 01:36:41,999 I WANTED TO SAY THAT OBVIOUSLY 2901 01:36:41,999 --> 01:36:43,234 SIMONS FOUNDATION HAS BEEN A 2902 01:36:43,234 --> 01:36:45,202 PIONEER IN SO MANY WAYS BUT ONE 2903 01:36:45,202 --> 01:36:46,537 WAY IN WHICH YOU GUYS HAVE BEEN 2904 01:36:46,537 --> 01:36:49,940 A REAL LEADER IS ON THE DATA 2905 01:36:49,940 --> 01:36:51,842 SHARING AND LONG TERM DATA 2906 01:36:51,842 --> 01:36:54,545 CURATION FROM SAFARI TO THE 2907 01:36:54,545 --> 01:36:55,179 CURRENT SIMONS COLLABORATIONS 2908 01:36:55,179 --> 01:36:58,015 AND I THINK THIS HAS BEEN A 2909 01:36:58,015 --> 01:37:00,317 CHALLENGE OF BRAIN INITIATIVE TO 2910 01:37:00,317 --> 01:37:02,753 NOT ONLY FUND BIG DATA SHARING 2911 01:37:02,753 --> 01:37:04,522 AND DISSEMINATION PROJECTS WHICH 2912 01:37:04,522 --> 01:37:06,123 WE ARE DOING, BUT ALSO THINKING 2913 01:37:06,123 --> 01:37:08,059 ABOUT LONG TERM DATA STORAGE. 2914 01:37:08,059 --> 01:37:09,627 WE ARE COLLECTING MASSIVE 2915 01:37:09,627 --> 01:37:10,394 DATASETS AND THE HOW ARE WE 2916 01:37:10,394 --> 01:37:12,029 GOING TO PROVIDE THEM AS A 2917 01:37:12,029 --> 01:37:14,265 RESOURCE OVER THE VERY LONG 2918 01:37:14,265 --> 01:37:14,465 TERM? 2919 01:37:14,465 --> 01:37:17,134 AND I THINK WHAT IS SO EXCITING 2920 01:37:17,134 --> 01:37:19,336 ABOUT THE COORDINATION BETWEEN 2921 01:37:19,336 --> 01:37:21,872 THESE DIFFERENT FOUNDATIONS IS 2922 01:37:21,872 --> 01:37:23,541 THAT THE SIMONS LEADERSHIP ON 2923 01:37:23,541 --> 01:37:25,443 THIS FRONT CAN REALLY HELP BRAIN 2924 01:37:25,443 --> 01:37:27,545 INITIATIVE TO DEVELOP THE LONG 2925 01:37:27,545 --> 01:37:28,846 TERM VISION FOR LONG TERM 2926 01:37:28,846 --> 01:37:29,747 STORAGE AND DATA. 2927 01:37:29,747 --> 01:37:31,449 IT'S USUALLY NOT THE MOST 2928 01:37:31,449 --> 01:37:33,050 EXCITING ASPECT OF WHAT WE DO. 2929 01:37:33,050 --> 01:37:35,086 WE WANT TO FUND NEW PROJECTS BUT 2930 01:37:35,086 --> 01:37:35,920 IT'S REALLY IMPORTANT, 2931 01:37:35,920 --> 01:37:37,755 ESPECIALLY AS THE DATASETS GET 2932 01:37:37,755 --> 01:37:39,156 MORE COMPLEX AND LARGER. 2933 01:37:39,156 --> 01:37:43,160 SO I WAS WONDERING IF YOU HAD 2934 01:37:43,160 --> 01:37:44,528 THOUGHTS ON HOW WE CAN WORK 2935 01:37:44,528 --> 01:37:47,264 TOGETHER AND WHAT WE CAN DO 2936 01:37:47,264 --> 01:37:49,733 MOVING FORWARD TO SORT OF MAKE 2937 01:37:49,733 --> 01:37:53,270 THAT A REALITY WITH LONG TERM 2938 01:37:53,270 --> 01:37:54,772 DATA SUPPORT. 2939 01:37:54,772 --> 01:37:55,139 >> ABSOLUTELY. 2940 01:37:55,139 --> 01:37:57,108 I THINK ESPECIALLY IF WE START 2941 01:37:57,108 --> 01:37:58,309 WITH NEUROSCIENCE COLLABORATIONS 2942 01:37:58,309 --> 01:38:00,444 AND LEARNING FROM SAFARI ON WHAT 2943 01:38:00,444 --> 01:38:04,582 THEY HAVE DONE ESPECIALLY IN THE 2944 01:38:04,582 --> 01:38:05,883 AUTISM GENETICS WORLD. 2945 01:38:05,883 --> 01:38:07,551 ONE OF THE THINGS WE ARE DEEPLY 2946 01:38:07,551 --> 01:38:09,787 PLANNING FOR IS NOT ONLY HO HOW 2947 01:38:09,787 --> 01:38:10,654 TO FUND THE CURRENT RESEARCH BUT 2948 01:38:10,654 --> 01:38:12,556 HOW TO SUPPORT WHERE THAT DATA 2949 01:38:12,556 --> 01:38:13,757 IS GOING TO GO, HOW LONG THE 2950 01:38:13,757 --> 01:38:15,359 LIFE OF THAT DATA IS GOING TO 2951 01:38:15,359 --> 01:38:15,559 BE. 2952 01:38:15,559 --> 01:38:18,662 AND THE ACTUAL INFRASTRUCTURE 2953 01:38:18,662 --> 01:38:20,097 LIKE LIKE THE PHYSICAL 2954 01:38:20,097 --> 01:38:20,965 INFRASTRUCTURE, THAT ALL HAS TO 2955 01:38:20,965 --> 01:38:23,467 BE WRITTEN UP AND FUNDED AS PART 2956 01:38:23,467 --> 01:38:25,202 OF THE NEW NEUROSCIENCE 2957 01:38:25,202 --> 01:38:25,803 COLLABORATIONS GOING FORWARD. 2958 01:38:25,803 --> 01:38:27,571 IT'S NOT SEPARATE FROM THE WORK. 2959 01:38:27,571 --> 01:38:30,107 IT IS INTEGRATED INTO THE WORK. 2960 01:38:30,107 --> 01:38:33,277 AND I WOULD BE HAPPY TO BRING IN 2961 01:38:33,277 --> 01:38:35,279 OR HAVE CONVERSATIONS AROUND HOW 2962 01:38:35,279 --> 01:38:37,081 WE ARE THINKING ABOUT IT AND 2963 01:38:37,081 --> 01:38:37,781 LEARNING FROM OTHERS HOW THEY 2964 01:38:37,781 --> 01:38:38,716 ARE THINKING ABOUT IT. 2965 01:38:38,716 --> 01:38:40,684 I THINK THAT WOULD BE A GREAT 2966 01:38:40,684 --> 01:38:42,186 WAY TO WORK TOGETHER. 2967 01:38:42,186 --> 01:38:43,320 JOHN, GO AHEAD. 2968 01:38:43,320 --> 01:38:43,821 >> THANK YOU. 2969 01:38:43,821 --> 01:38:45,022 WE DEFINITELY ARE LOOKING 2970 01:38:45,022 --> 01:38:48,092 FORWARD TO LEARNING FROM YOU AND 2971 01:38:48,092 --> 01:38:51,495 HOPEFULLY EACH OTHER IN THIS 2972 01:38:51,495 --> 01:38:53,797 VERY RAPIDLY-EVOLVING SPACE. 2973 01:38:53,797 --> 01:38:56,567 I ALWAYS SAID IF WE DON'T KNOW 2974 01:38:56,567 --> 01:38:59,370 THE DATA IT WILL EAT US ALIVE. 2975 01:38:59,370 --> 01:39:00,571 IT'S VERY IMPORTANT. 2976 01:39:00,571 --> 01:39:03,007 CURRENTLY OUR BIGGEST DATA 2977 01:39:03,007 --> 01:39:05,009 GENERATING PROJECT IS THE CELL 2978 01:39:05,009 --> 01:39:06,510 CENSUS PROJECT BUT WE GOT THE 2979 01:39:06,510 --> 01:39:07,678 CONNECT ACTIVITY I PROJECT 2980 01:39:07,678 --> 01:39:09,413 COMING DOWN THE LINE. 2981 01:39:09,413 --> 01:39:12,416 WE HAVE BRAIN BEHAVIORAL 2982 01:39:12,416 --> 01:39:13,717 SYNCHRONIZATION. 2983 01:39:13,717 --> 01:39:14,785 CELL CENSUS PROJECT. 2984 01:39:14,785 --> 01:39:16,720 BUT WE ARE DOING THE BEST TO SET 2985 01:39:16,720 --> 01:39:18,989 VERY HIGH STANDARDS FOR NOT JUST 2986 01:39:18,989 --> 01:39:20,824 OURSELVES BUT FOR THE FIELD SO 2987 01:39:20,824 --> 01:39:24,495 THE DATA WILL BE TRULY 2988 01:39:24,495 --> 01:39:26,597 ACCESSIBLE AND INTEROPERABLE AND 2989 01:39:26,597 --> 01:39:26,897 REUSABLE. 2990 01:39:26,897 --> 01:39:29,200 NOT JUST AN ACRONYM BUT WALK THE 2991 01:39:29,200 --> 01:39:29,600 WALK. 2992 01:39:29,600 --> 01:39:31,936 AND THERE IS A LOT OF 2993 01:39:31,936 --> 01:39:33,904 INTERACTION BETWEEN THE BRAIN 2994 01:39:33,904 --> 01:39:35,806 INITIATIVE AND CELL CENSUS 2995 01:39:35,806 --> 01:39:38,275 PROJECT AND THE HUMAN CELL ATLAS 2996 01:39:38,275 --> 01:39:38,609 PROJECT. 2997 01:39:38,609 --> 01:39:40,711 AND I THINK IT'S HAVING THE 2998 01:39:40,711 --> 01:39:41,412 CONNECTIONS BETWEEN THESE 2999 01:39:41,412 --> 01:39:43,814 PROGRAMS THROUGH THE 3000 01:39:43,814 --> 01:39:45,950 INVESTIGATORS SO WILL HELP 3001 01:39:45,950 --> 01:39:47,218 FACILITATE THIS MUTUAL LEARNING 3002 01:39:47,218 --> 01:39:47,518 EXPERIENCE. 3003 01:39:47,518 --> 01:39:48,586 WE ARE LOOKING FORWARD TO SEE 3004 01:39:48,586 --> 01:39:50,020 WHAT YOU HAVE TO DO AND 3005 01:39:50,020 --> 01:39:52,022 HOPEFULLY LEARNING A FEW TRICKS 3006 01:39:52,022 --> 01:39:53,624 WE CAN BORROW AS WELL. 3007 01:39:53,624 --> 01:39:53,991 >> ABSOLUTELY. 3008 01:39:53,991 --> 01:39:54,925 I THINK ONE OF THE THINGS WE 3009 01:39:54,925 --> 01:39:56,427 HAVE HEARD LOUD AND CLEAR FROM 3010 01:39:56,427 --> 01:39:59,430 OUR INVESTIGATORS IS NOT JUST 3011 01:39:59,430 --> 01:40:01,498 SIMPLY HOUSING AND STORING THE 3012 01:40:01,498 --> 01:40:01,699 DATA. 3013 01:40:01,699 --> 01:40:02,333 IT'S NOT ENOUGH. 3014 01:40:02,333 --> 01:40:04,235 IT'S FUNDING PEOPLE TO ACTUALLY 3015 01:40:04,235 --> 01:40:05,936 CONTINUALLY BE ON TOP OF THESE 3016 01:40:05,936 --> 01:40:09,740 DATABASES AND USER INTERFACES 3017 01:40:09,740 --> 01:40:10,541 AND TOOLS PEOPLE CAN'T ACCESS 3018 01:40:10,541 --> 01:40:11,642 AND UNDERSTAND THE DATA. 3019 01:40:11,642 --> 01:40:12,943 IT'S JUST GOING TO SIT THERE. 3020 01:40:12,943 --> 01:40:15,813 SO THOSE ARE THE KINDS OF THINGS 3021 01:40:15,813 --> 01:40:16,847 WE ARE PLANNING FOR AND FUNDING 3022 01:40:16,847 --> 01:40:18,616 AS PART OF THESE AWARDS MOVING 3023 01:40:18,616 --> 01:40:19,516 FORWARD. 3024 01:40:19,516 --> 01:40:19,817 >> RIGHT. 3025 01:40:19,817 --> 01:40:21,652 AND ONE OF THE BIG CHALLENGES WE 3026 01:40:21,652 --> 01:40:22,953 CREATED FOR OURSELVES, JUST 3027 01:40:22,953 --> 01:40:24,622 USING THE CELL CENSUS PROJECT AS 3028 01:40:24,622 --> 01:40:25,256 AN EXAMPLE. 3029 01:40:25,256 --> 01:40:27,024 IT'S NOT THE BEGINNING OR END. 3030 01:40:27,024 --> 01:40:28,926 HOW DO YOU GO FROM HAVING THESE 3031 01:40:28,926 --> 01:40:32,263 LARGE DATABASES LIKE STUFF YOU 3032 01:40:32,263 --> 01:40:33,163 BASICALLY CALL THEM STORAGE AND 3033 01:40:33,163 --> 01:40:36,033 TURN THAT INTO A KNOWLEDGE BASE? 3034 01:40:36,033 --> 01:40:36,834 AND USE IT. 3035 01:40:36,834 --> 01:40:39,837 THAT'S GOING TO BE A FUN 3036 01:40:39,837 --> 01:40:44,108 CHALLENGE TO ADDRESS. 3037 01:40:44,108 --> 01:40:48,646 >> ABSOLUTELY. 3038 01:40:48,646 --> 01:40:48,946 >> GREAT. 3039 01:40:48,946 --> 01:40:50,547 IF THERE ARE NO MORE QUESTIONS. 3040 01:40:50,547 --> 01:40:51,415 THANK YOU VERY MUCH. 3041 01:40:51,415 --> 01:40:53,651 IT WAS A PLEASURE TALKING TO YOU 3042 01:40:53,651 --> 01:40:53,851 TODAY. 3043 01:40:53,851 --> 01:40:55,352 >> THANK YOU VERY MUCH. 3044 01:40:55,352 --> 01:41:03,093 GREAT PRESENTATION. 3045 01:41:03,093 --> 01:41:04,061 UNLESS ANYBODY HAS ANY MORE 3046 01:41:04,061 --> 01:41:05,262 GENERAL QUESTIONS, WE HAVE A 3047 01:41:05,262 --> 01:41:06,864 LITTLE BIT MORE TIME FOR OUR 3048 01:41:06,864 --> 01:41:07,164 BREAK. 3049 01:41:07,164 --> 01:41:08,966 BUT JUST OPEN IT UP BEFORE THEN 3050 01:41:08,966 --> 01:41:11,035 IN CASE ANYONE HAS ANYTHING ELSE 3051 01:41:11,035 --> 01:41:14,405 TO ASK JOHN OR ANYBODY ELSE IN 3052 01:41:14,405 --> 01:41:18,042 THE ROOM. 3053 01:41:18,042 --> 01:41:21,612 >> I HAD A GENERAL QUESTION. 3054 01:41:21,612 --> 01:41:23,247 IN THE CONTEXT OF THIS LAST 3055 01:41:23,247 --> 01:41:24,748 POINT, BEING ABLE TO FULLY 3056 01:41:24,748 --> 01:41:28,352 LEVERAGE ALL OF THIS DATA, I'M 3057 01:41:28,352 --> 01:41:32,256 ON AN NIA-FUNDED GROUP PROJECT 3058 01:41:32,256 --> 01:41:33,857 IDENTIFYING THERAPEUTIC 3059 01:41:33,857 --> 01:41:36,060 CANDIDATES AND I'D SAY ABOUT 3060 01:41:36,060 --> 01:41:40,064 HALF OF OUR TEAM ARE DATA 3061 01:41:40,064 --> 01:41:40,664 SCIENTISTS AND THE OTHER HALF 3062 01:41:40,664 --> 01:41:43,067 ARE BIOLOGY PEOPLE LIKE ME. 3063 01:41:43,067 --> 01:41:46,603 AND IT'S BEEN FASCINATING 3064 01:41:46,603 --> 01:41:47,104 OBSERVING. 3065 01:41:47,104 --> 01:41:48,372 WE HAVE DIFFERENT TRAINING AND 3066 01:41:48,372 --> 01:41:49,873 EXPERIENCE AND I THINK THERE IS 3067 01:41:49,873 --> 01:41:52,109 STILL A BIG GAP THERE. 3068 01:41:52,109 --> 01:41:55,679 I DON'T KNOW AS A BIOLOGICAL 3069 01:41:55,679 --> 01:41:57,881 THINKER I'M CAPABLE OF FULLY 3070 01:41:57,881 --> 01:41:59,516 LEVERAGING THESE DATASETS. 3071 01:41:59,516 --> 01:42:01,785 AND I KNOW MY COLLEAGUES WHO 3072 01:42:01,785 --> 01:42:04,288 DEVOTED CAREERS TO DATA SCIENCE, 3073 01:42:04,288 --> 01:42:06,390 THEY HAVEN'T SPENT 20-30 YEARS 3074 01:42:06,390 --> 01:42:09,460 THINKING ABOUT THESE BIOLOGIC 3075 01:42:09,460 --> 01:42:09,927 PROBLEMS. 3076 01:42:09,927 --> 01:42:12,663 AND I'M JUST WONDERING WHAT ARE 3077 01:42:12,663 --> 01:42:15,499 BETTER WAYS TO FLAIRO THIS GAP? 3078 01:42:15,499 --> 01:42:18,302 WE WORK COLLABORATIVELY, BUT I 3079 01:42:18,302 --> 01:42:20,904 COULD JUST SEE THE THINKING IS 3080 01:42:20,904 --> 01:42:21,171 DIFFERENT. 3081 01:42:21,171 --> 01:42:24,375 I MEAN EVEN WITH INTERFACES AND 3082 01:42:24,375 --> 01:42:24,675 EVERYTHING. 3083 01:42:24,675 --> 01:42:26,276 I DON'T KNOW IF SOMEONE LIKE ME 3084 01:42:26,276 --> 01:42:28,178 SITTING DOWN WITH ONE OF THESE 3085 01:42:28,178 --> 01:42:32,816 DATABASES COULD FULLY LEVERAGE 3086 01:42:32,816 --> 01:42:32,983 IT. 3087 01:42:32,983 --> 01:42:35,185 SO I THINK MAYBE THERE IS ROOM 3088 01:42:35,185 --> 01:42:37,121 FOR DEVELOPING THAT CAPABILITY 3089 01:42:37,121 --> 01:42:39,923 OR BRIDGING THOSE AREAS. 3090 01:42:39,923 --> 01:42:42,326 >> I AGREE, FRANK. 3091 01:42:42,326 --> 01:42:45,095 I THINK THE GOOD NEWS IS THAT 3092 01:42:45,095 --> 01:42:47,431 THE TRAINING THAT FOLKS COMING 3093 01:42:47,431 --> 01:42:49,733 INTO THE FIELD NOW WHO ARE 3094 01:42:49,733 --> 01:42:52,770 ENTERING THE FIELD NOW, THE I 3095 01:42:52,770 --> 01:42:54,204 DON'T THINKER -- I'LL BE BLUNT. 3096 01:42:54,204 --> 01:42:55,406 THE YOUNGER FOLKS. 3097 01:42:55,406 --> 01:42:57,508 ARE GETTING MORE OF THIS. 3098 01:42:57,508 --> 01:42:59,543 IT'S MORE IN THEIR FABRIC OF THE 3099 01:42:59,543 --> 01:43:02,212 TRAINING COMING IN. 3100 01:43:02,212 --> 01:43:03,914 SO, I BELIEVE THAT HAVING THIS 3101 01:43:03,914 --> 01:43:05,516 KIND OF QUANTITATIVE TRAINING, 3102 01:43:05,516 --> 01:43:07,284 MANY OF US HAVE QUANTITATIVE 3103 01:43:07,284 --> 01:43:10,120 COMING IN, BUT COMBINED WITH THE 3104 01:43:10,120 --> 01:43:12,222 BIOLOGY EARLIER IN THEIR 3105 01:43:12,222 --> 01:43:13,924 EDUCATIONAL LIFETIME WHEN THEY 3106 01:43:13,924 --> 01:43:15,292 ARE STILL MORE PLASTIC THAN SOME 3107 01:43:15,292 --> 01:43:16,827 OF US, WILL HELP. 3108 01:43:16,827 --> 01:43:17,828 BUT YOU'RE RIGHT. 3109 01:43:17,828 --> 01:43:19,129 IT'S NOT JUST ENOUGH TO 3110 01:43:19,129 --> 01:43:21,098 COLLABORATE WITH FOLKS WHO KNOW 3111 01:43:21,098 --> 01:43:21,999 IT. 3112 01:43:21,999 --> 01:43:24,535 AND I HAD JUST LITERAL JOY OF 3113 01:43:24,535 --> 01:43:25,803 WORKING WITH PEOPLE IN 3114 01:43:25,803 --> 01:43:28,205 STATISTICS AND COMPUTER SCIENCE. 3115 01:43:28,205 --> 01:43:29,907 AND THE JOY CAME BECAUSE WE KIND 3116 01:43:29,907 --> 01:43:31,041 OF GOT EACH OTHER. 3117 01:43:31,041 --> 01:43:32,209 AND MAYBE THAT WAS A HAPPY 3118 01:43:32,209 --> 01:43:33,610 ACCIDENT BUT WHEN YOU FIND IT, 3119 01:43:33,610 --> 01:43:36,613 DON'T LET GO OF IT. 3120 01:43:36,613 --> 01:43:38,849 AND IT'S A MATTER OF THEY'RE 3121 01:43:38,849 --> 01:43:40,951 LOOKING IN MANY CASES FOR A 3122 01:43:40,951 --> 01:43:43,086 REALLY TOUGH PROBLEM-SOLVE AND 3123 01:43:43,086 --> 01:43:44,054 AT WHO POINT THE STATISTICIAN 3124 01:43:44,054 --> 01:43:45,622 SAID WE LIKE YOUR CRAPPY DATA 3125 01:43:45,622 --> 01:43:47,124 BECAUSE IT MEANS WE HAVE TO 3126 01:43:47,124 --> 01:43:48,325 EVOLVE A BETTER WAY OF DEALING 3127 01:43:48,325 --> 01:43:49,927 WITH IT. 3128 01:43:49,927 --> 01:43:52,429 BUT MORE DEEP BIOLOGICAL 3129 01:43:52,429 --> 01:43:53,630 QUESTIONS WE FRANKLY DON'T HAVE 3130 01:43:53,630 --> 01:43:55,966 A WAY OF GETTING AT AND TO HAVE 3131 01:43:55,966 --> 01:43:58,669 THEM APPLY FUNDAMENTAL 3132 01:43:58,669 --> 01:44:01,572 QUANTITATIVE PRINCIPLES TO THAT 3133 01:44:01,572 --> 01:44:02,406 TO FIND SLIDESES IS 3134 01:44:02,406 --> 01:44:02,739 EXHILARATING. 3135 01:44:02,739 --> 01:44:04,842 AND NOW WE ARE ENTERING A NEW 3136 01:44:04,842 --> 01:44:08,178 AREA OF AI WHERE WE HAVE TO BE 3137 01:44:08,178 --> 01:44:09,546 MINDFUL OF WHERE THE GROUND 3138 01:44:09,546 --> 01:44:11,715 TRUTH IS OR WE MIGHT WIND UP 3139 01:44:11,715 --> 01:44:11,949 LOST. 3140 01:44:11,949 --> 01:44:15,018 BUT THERE REALLY IS A HUGE 3141 01:44:15,018 --> 01:44:17,154 OPPORTUNITY TO EXTRACT FROM THE 3142 01:44:17,154 --> 01:44:19,256 DATA INFORMATION THAT WE 3143 01:44:19,256 --> 01:44:21,859 LITERALLY DON'T FULLY APPRECIATE 3144 01:44:21,859 --> 01:44:24,995 EXIST OR NOT IN A WAY WE CAN 3145 01:44:24,995 --> 01:44:25,262 LEVERAGE. 3146 01:44:25,262 --> 01:44:26,063 I'M HOPEFUL THAT WE CAN DO THIS 3147 01:44:26,063 --> 01:44:28,665 BUT IT WILL TAKE A COLLABORATION 3148 01:44:28,665 --> 01:44:31,802 AND BEING ABLE TO TALK THE SAME 3149 01:44:31,802 --> 01:44:33,270 LANGUAGE AT SOME LEVEL. 3150 01:44:33,270 --> 01:44:35,072 AND I THINK HOPEFULLY THROUGH 3151 01:44:35,072 --> 01:44:36,974 BRINGING IN MORE DIVERSE 3152 01:44:36,974 --> 01:44:39,476 PERSPECTIVES ON TO OUR TEAMS 3153 01:44:39,476 --> 01:44:40,777 WILL GET THOSE CONVERSATIONS 3154 01:44:40,777 --> 01:44:43,447 GOING AND HOW TO TEACH PEOPLE TO 3155 01:44:43,447 --> 01:44:44,848 SPEAK A COMMON LANGUAGE. 3156 01:44:44,848 --> 01:44:48,252 THAT'S A HIGH-LEVEL ENTHUSIAST 3157 01:44:48,252 --> 01:44:49,152 OPTIMISTIC VIEW BUT I THINK THIS 3158 01:44:49,152 --> 01:44:50,554 IS SOMETHING WE CAN ASPIRE TO. 3159 01:44:50,554 --> 01:44:52,189 WE WILL HAVE TO IF WE'RE GOING 3160 01:44:52,189 --> 01:44:57,027 TO SOLVE THESE PROBLEMS. 3161 01:44:57,027 --> 01:44:57,561 >> THANK YOU. 3162 01:44:57,561 --> 01:44:59,363 >> I WAS GOING TO SAY ALSO, WITH 3163 01:44:59,363 --> 01:45:00,964 RESPECT TO TRAINING, ONE OF THE 3164 01:45:00,964 --> 01:45:03,667 ISSUES THAT I'M INVOLVED WITH 3165 01:45:03,667 --> 01:45:06,970 THE HBCD RESEARCH PROJECT, VERY, 3166 01:45:06,970 --> 01:45:07,938 VERY LARGE INITIATIVES 3167 01:45:07,938 --> 01:45:09,506 COLLECTING A LOT OF DATA, AND 3168 01:45:09,506 --> 01:45:10,874 THERE ARE ISSUES AROUND THE 3169 01:45:10,874 --> 01:45:12,476 ETHICAL USE OF DATA AS WELL. 3170 01:45:12,476 --> 01:45:13,944 SO NOT JUST TRAINING PEOPLE HOW 3171 01:45:13,944 --> 01:45:15,879 TO USE THE DATA AND WHAT THEY 3172 01:45:15,879 --> 01:45:17,581 NEED TO THINK ABOUT WHEN SETTING 3173 01:45:17,581 --> 01:45:19,883 UP THEIR MODELS, BUT WE'RE 3174 01:45:19,883 --> 01:45:22,886 ALREADY SEEING INSTANCES WHERE 3175 01:45:22,886 --> 01:45:25,856 THERE WAS A LOT OF POTENTIAL FOR 3176 01:45:25,856 --> 01:45:28,859 UNETHICAL USE OF INFORMATION 3177 01:45:28,859 --> 01:45:29,893 TOWARDS WHICH COULD HURT 3178 01:45:29,893 --> 01:45:31,962 PARTICULAR POPULATIONS OR 3179 01:45:31,962 --> 01:45:33,163 POLITICAL IMPLICATIONS. 3180 01:45:33,163 --> 01:45:34,398 SO I THINK THERE IS A LOT OF 3181 01:45:34,398 --> 01:45:35,799 TRAINING AND THINKING ABOUT HOW 3182 01:45:35,799 --> 01:45:38,201 THE DATA ARE BEING USED THAT 3183 01:45:38,201 --> 01:45:44,608 NEEDS TO HAPPEN AS WE GO 3184 01:45:44,608 --> 01:45:45,008 FORWARD. 3185 01:45:45,008 --> 01:45:46,476 >> I'LL JUST ADD FRANK, TO YOUR 3186 01:45:46,476 --> 01:45:48,712 POINT ABOUT THE UNDERSTANDING 3187 01:45:48,712 --> 01:45:49,746 AND THE COLLABORATION. 3188 01:45:49,746 --> 01:45:51,582 I THINK ONE OF THE THINGS THAT 3189 01:45:51,582 --> 01:45:52,382 DEFINITELY NOT THE ONLY WAY TO 3190 01:45:52,382 --> 01:45:54,618 DO IT, BUT ONE OF THE SUCCESS 3191 01:45:54,618 --> 01:45:56,587 SYSTEM OF OUR GLOBAL BRAIN 3192 01:45:56,587 --> 01:45:57,688 COLLABORATION IS AT THE VERY 3193 01:45:57,688 --> 01:46:00,891 OUTSET WE PUT OUT A CALL FOR 3194 01:46:00,891 --> 01:46:03,794 AWARDS THAT WERE BOTH THEORY AND 3195 01:46:03,794 --> 01:46:06,496 COMPUTATION AND THAT WENT 3196 01:46:06,496 --> 01:46:07,097 HAND-IN-HAND TOGETHER. 3197 01:46:07,097 --> 01:46:09,700 WE FUNDED THOSE AWARDS WITH THAT 3198 01:46:09,700 --> 01:46:11,101 FRAME, WE ALSO DESIGNED PROGRAMS 3199 01:46:11,101 --> 01:46:13,103 AND FACILITATED THEM GETTING 3200 01:46:13,103 --> 01:46:15,005 TOGETHER IN PERSON AND OTHERWISE 3201 01:46:15,005 --> 01:46:17,808 TO SORT OF HAVE THEM TALK 3202 01:46:17,808 --> 01:46:20,210 TOGETHER, USE THE SAME WORDS, 3203 01:46:20,210 --> 01:46:21,144 DEEPLY UNDERSTAND EACH OTHER. 3204 01:46:21,144 --> 01:46:23,614 SO IT DOES TAKE A CONCERTED 3205 01:46:23,614 --> 01:46:25,616 EFFORT TO THE HAVE OR TO 3206 01:46:25,616 --> 01:46:27,851 OVERCOME THESE LANGUAGE BARRIERS 3207 01:46:27,851 --> 01:46:30,220 AND SORT OF -- IT'S NOT EACH 3208 01:46:30,220 --> 01:46:30,520 CONCEPTUAL. 3209 01:46:30,520 --> 01:46:33,156 IT'S THE WORDS YOU USE AROUND IT 3210 01:46:33,156 --> 01:46:34,224 AND THE LINEAGE OF YOUR 3211 01:46:34,224 --> 01:46:35,125 BACKGROUND IS SO DIFFERENT. 3212 01:46:35,125 --> 01:46:36,493 AND IT TAKES TWO PEOPLE BEING 3213 01:46:36,493 --> 01:46:37,294 REALLY COMMITTED. 3214 01:46:37,294 --> 01:46:38,428 AND I THINK JOHN IS RIGHT. 3215 01:46:38,428 --> 01:46:40,897 WE HAVE TO DO IT BUT THAT WAS 3216 01:46:40,897 --> 01:46:43,834 ONE WAY THAT WE FOUND IT TO BE 3217 01:46:43,834 --> 01:46:46,536 VERY SUCCESSFUL IS TO BE VERY 3218 01:46:46,536 --> 01:46:48,505 POINTED AND DIRECTED ABOUT 3219 01:46:48,505 --> 01:46:49,940 FUNDING THAT AND FACILITATING 3220 01:46:49,940 --> 01:46:52,409 THAT COLLABORATION. 3221 01:46:52,409 --> 01:46:52,743 >> I THINK? 3222 01:46:52,743 --> 01:46:53,744 IS GREAT. 3223 01:46:53,744 --> 01:46:56,013 I THINK THE FUNDING SOURCE IS 3224 01:46:56,013 --> 01:46:58,815 PROMOTING THAT AND IS VERY 3225 01:46:58,815 --> 01:46:59,816 HELPFUL. 3226 01:46:59,816 --> 01:47:05,589 THE OTHER GREAT OPPORTUNITY IS 3227 01:47:05,589 --> 01:47:08,425 WITH THE DATA SCIENCE RICH 3228 01:47:08,425 --> 01:47:09,726 APPROACHES AND DISHED AI 3229 01:47:09,726 --> 01:47:12,929 APPROACHES, IT BRINGS UP A SKILL 3230 01:47:12,929 --> 01:47:15,932 SET INNING IN WHEN TO DO AN 3231 01:47:15,932 --> 01:47:17,668 EXPERIMENT THAT HAS MASSIVE 3232 01:47:17,668 --> 01:47:17,901 IMPACT. 3233 01:47:17,901 --> 01:47:21,038 I THINK THAT IS EMERGING SKILL 3234 01:47:21,038 --> 01:47:21,471 SET TOO. 3235 01:47:21,471 --> 01:47:24,241 I CAN SEE OUR YOUNGER COLLEAGUES 3236 01:47:24,241 --> 01:47:25,442 IN THE TRAINING PROGRAMS ARE 3237 01:47:25,442 --> 01:47:27,310 GETTING MORE AND MORE OF THIS 3238 01:47:27,310 --> 01:47:33,316 CAPABILITY WHICH IS GREAT TO S 3239 01:47:33,316 --> 01:47:39,523 SEE. 3240 01:47:39,523 --> 01:47:41,258 >> SO IF THERE ARE NO OTHER 3241 01:47:41,258 --> 01:47:42,559 COMMENTS ON QUESTIONS, THANK YOU 3242 01:47:42,559 --> 01:47:42,959 ALL. 3243 01:47:42,959 --> 01:47:45,629 WE WILL RECONVENE AT 2:30. 3244 01:47:45,629 --> 01:47:49,933 SO YOU HAVE 40 MINUTES. 3245 01:47:49,933 --> 01:47:53,170 PLEASE USE THE NEW ZOOM LINK FOR 3246 01:47:53,170 --> 01:47:56,840 MEMBERS OF COUNCIL AND FOR 3247 01:47:56,840 --> 01:47:57,874 GOVERNMENT STAFF. 3248 01:47:57,874 --> 01:47:59,776 SO SEE YOU IN A LITTLE WHILE. 3249 01:47:59,776 --> 01:48:00,644 >> THANK YOU, ALL. 3250 01:48:00,644 --> 01:48:11,088 SEE YOU IN CLOSED SESSION.