1 00:00:05,000 --> 00:00:10,280 >>WELCOME, EVERYONE. WE ARE 2 00:00:10,280 --> 00:00:12,680 GOING TO GET STARTED IN JUST A 3 00:00:12,680 --> 00:00:17,880 MOMENT. SORRY FOR THE DELAY. I 4 00:00:17,880 --> 00:00:19,760 HAD SOME TECHNICAL CHALLENGES ON 5 00:00:19,760 --> 00:00:22,600 THIS END BUT WE ARE ABOUT TO GET 6 00:00:22,600 --> 00:00:25,880 IT GOING. ALL RIGHT. TRACY, WE 7 00:00:25,880 --> 00:00:28,800 ARE READY? 8 00:00:28,800 --> 00:00:30,120 >> QUESTION ARE READY, EVERYONE 9 00:00:30,120 --> 00:00:31,560 IS ACCOUNTED FOR AND WE ARE 10 00:00:31,560 --> 00:00:32,920 READY TO GET STARTED. 11 00:00:32,920 --> 00:00:34,960 >> OKAY. THEN I WOULD LIKE TO 12 00:00:34,960 --> 00:00:37,160 WELCOME YOU TO THE 267TH MEETING 13 00:00:37,160 --> 00:00:39,200 OF NATIONAL ADVISORY MENTAL 14 00:00:39,200 --> 00:00:42,000 HEALTH COUNCIL. I'M JOSH GORDON, 15 00:00:42,000 --> 00:00:43,040 DIRECTOR OF NATIONAL INSTITUTE 16 00:00:43,040 --> 00:00:47,000 OF MENTAL HEALTH. THANK YOU FOR 17 00:00:47,000 --> 00:00:48,520 JOINING OUR COUNCIL MEETING. 18 00:00:48,520 --> 00:00:50,960 THANK YOU TO THE MEMBERS COMING 19 00:00:50,960 --> 00:00:52,640 THE NIMH STAFF FOR ALL THEIR 20 00:00:52,640 --> 00:00:55,280 WORK IN PREPARATION, AND 21 00:00:55,280 --> 00:00:57,280 ESPECIALLY THOSE MEMBERS OF THE 22 00:00:57,280 --> 00:00:59,880 DEA STAFF WHO WORK ON THE 23 00:00:59,880 --> 00:01:02,440 COUNCIL AS WELL AS OUR OSPPC 24 00:01:02,440 --> 00:01:05,520 STAFF OFFICE OF SCIENTIFIC 25 00:01:05,520 --> 00:01:06,720 POLICY COMMUNICATION PLANNING 26 00:01:06,720 --> 00:01:08,280 STAFF THAT HELPED PREPARE MY 27 00:01:08,280 --> 00:01:09,640 PRESENTATION FOR THE DAY. OUR 28 00:01:09,640 --> 00:01:12,000 COUNCIL MEETING IS A TIME FOR 29 00:01:12,000 --> 00:01:13,680 EXCHANGE BETWEEN INSTITUTE STAFF 30 00:01:13,680 --> 00:01:15,480 AND COUNCIL MEMBERS. AS WELL AS 31 00:01:15,480 --> 00:01:16,280 AN OPPORTUNITY FOR THE COUNCIL 32 00:01:16,280 --> 00:01:18,840 TO PROVIDE FEEDBACK TO THE 33 00:01:18,840 --> 00:01:20,600 NATIONAL MENTAL HEALTH AND 34 00:01:20,600 --> 00:01:24,360 IMPORTANTLY TODAY'S OPEN SESSION 35 00:01:24,360 --> 00:01:26,200 IS A OPPORTUNITY FOR NIMH AND 36 00:01:26,200 --> 00:01:28,640 COUNCIL MEMBERS TO COMMUNICATE 37 00:01:28,640 --> 00:01:30,840 TO THE VARIOUS CONSTITUENCIES 38 00:01:30,840 --> 00:01:36,960 THAT CONCERN THEMSELVES WITH OUR 39 00:01:36,960 --> 00:01:38,080 GOINGS ON. I'M PLEASED TO SEE 40 00:01:38,080 --> 00:01:39,480 THE FULL PANEL OF COUNCIL 41 00:01:39,480 --> 00:01:40,640 MEMBERS INCLUDING SOME WHO HAVE 42 00:01:40,640 --> 00:01:42,560 BEEN ABLE TO OFFICIALLY JOIN US 43 00:01:42,560 --> 00:01:44,320 TODAY. AS FULL MEMBERS OF THE 44 00:01:44,320 --> 00:01:45,840 COUNCIL VERY EXCITED TO BE ABLE 45 00:01:45,840 --> 00:01:49,040 TO JOIN YOU IN DISCUSSIONS. AND 46 00:01:49,040 --> 00:01:50,560 I LOOK FORWARD TO HEARING FROM 47 00:01:50,560 --> 00:01:52,960 ALL OF YOU ON OUR DISCUSSIONS 48 00:01:52,960 --> 00:01:55,640 TODAY. BEFORE WE MOVE THE 49 00:01:55,640 --> 00:01:56,840 BUSINESS OF THE MEETING I DO 50 00:01:56,840 --> 00:01:59,880 WANT TO REMIND ALL OF US A FEW 51 00:01:59,880 --> 00:02:00,840 LOGISTICAL ITEMS. THE OPEN 52 00:02:00,840 --> 00:02:03,800 SESSION OF COUNCIL IS BEING 53 00:02:03,800 --> 00:02:04,480 VIDEOCAST, BROADLY, THE NIH 54 00:02:04,480 --> 00:02:06,480 COMMUNITY AS WELL AS THE GENERAL 55 00:02:06,480 --> 00:02:08,920 PUBLIC. THAT ALLOWS PEOPLE TO 56 00:02:08,920 --> 00:02:11,120 WATCH AND LISTEN REMOTELY. 57 00:02:11,120 --> 00:02:12,680 MEETING IS ALSO BEING RECORDED 58 00:02:12,680 --> 00:02:15,280 AND THAT WILL ENABLE VIEWING ON 59 00:02:15,280 --> 00:02:18,400 DEMAND IN THE FUTURE. MEETING IS 60 00:02:18,400 --> 00:02:21,200 ALSO BEING TRANSCRIBED FOR THE 61 00:02:21,200 --> 00:02:23,200 RECORD. SO ALL OF THAT MEANS I 62 00:02:23,200 --> 00:02:26,560 WANT TO REMIND YOU ABOUT SOME 63 00:02:26,560 --> 00:02:28,480 ZOOM ETIQUETTE. FIRST WE WANT TO 64 00:02:28,480 --> 00:02:29,800 ENCOURAGE COUNCIL MEMBERS TO 65 00:02:29,800 --> 00:02:30,920 KEEP THEIR VIDEO ON THROUGHOUT 66 00:02:30,920 --> 00:02:33,840 THE MEETING. I WILL ASK NIMH 67 00:02:33,840 --> 00:02:35,680 STAFF AND DIVISION DIRECTORS AND 68 00:02:35,680 --> 00:02:37,400 OTHERS WHO ARE SPEAKING TO US 69 00:02:37,400 --> 00:02:40,440 TODAY TO USE THEIR VIDEO ONLY 70 00:02:40,440 --> 00:02:43,000 WHEN PRESENTING. IN ORDER TO 71 00:02:43,000 --> 00:02:45,160 SPEAK PLEASE UNMUTE YOUR 72 00:02:45,160 --> 00:02:46,520 MICROPHONE AND THEN MUTE IT 73 00:02:46,520 --> 00:02:49,400 AGAIN WHEN YOU ARE DONE. IF 74 00:02:49,400 --> 00:02:51,160 ANYONE IS USING PHONE FOR AUDIO 75 00:02:51,160 --> 00:02:52,960 AND DOESN'T HAVE ACCESS TO MUTE 76 00:02:52,960 --> 00:02:56,520 BUTTON ON COMPUTER IN THE APP 77 00:02:56,520 --> 00:02:57,320 PLEASE PRESS "*" 6 TO MUTE OR 78 00:02:57,320 --> 00:03:00,440 UNMUTED. WE ASK COUNCIL MEMBERS 79 00:03:00,440 --> 00:03:04,920 TO UNMUTE TO MAKE A COMMENT OR 80 00:03:04,920 --> 00:03:06,600 RAISE YOUR HAND TO MAKE A 81 00:03:06,600 --> 00:03:07,720 COMMENT OR ASK A QUESTION. 82 00:03:07,720 --> 00:03:08,920 RATHER THAN USING THE CHAT 83 00:03:08,920 --> 00:03:09,760 FUNCTION. THE CHAT FUNCTION 84 00:03:09,760 --> 00:03:13,080 SHOULD BE USED ONLY TO CONTACT 85 00:03:13,080 --> 00:03:15,240 THE NIMH HOSTS WITH TECHNICAL 86 00:03:15,240 --> 00:03:16,640 ISSUES. I WILL NOTE THAT 87 00:03:16,640 --> 00:03:18,240 ANYTHING YOU DO ENTER IN THE 88 00:03:18,240 --> 00:03:21,040 CHAT BOX IS INCLUDED IN THE 89 00:03:21,040 --> 00:03:22,760 PERMANENT RECORD OF THIS SESSION 90 00:03:22,760 --> 00:03:23,400 AND WILL BE VIEWABLE BY MEMBERS 91 00:03:23,400 --> 00:03:29,880 OF THE PUBLIC. WHEN WE CALL FOR 92 00:03:29,880 --> 00:03:30,880 A VOTED WE WILL ASK COUNCIL 93 00:03:30,880 --> 00:03:32,360 MEMBERS TO USE THE RAISE HAND 94 00:03:32,360 --> 00:03:34,800 FUNCTION AT THE BOTTOM OF THE 95 00:03:34,800 --> 00:03:35,840 OMEN EWE OR IT MAY BE IN YOUR 96 00:03:35,840 --> 00:03:37,640 APP AT THE BOTTOM UNDER THE 97 00:03:37,640 --> 00:03:41,840 REACTIONS MENU. VOTING COUNCIL 98 00:03:41,840 --> 00:03:43,720 MEMBERS ON PHONE SHOULD UNMUTE 99 00:03:43,720 --> 00:03:47,080 BY PRESSING STAR 6 TO CAPTURE 100 00:03:47,080 --> 00:03:48,520 YOUR VOICE. IF YOU EXPERIENCE 101 00:03:48,520 --> 00:03:50,560 CONNECTIVITY ISSUES AND NEED TO 102 00:03:50,560 --> 00:03:52,040 CALL IN, PLEASE REFER TO YOUR 103 00:03:52,040 --> 00:03:54,000 PERSONAL ZOOM ITINERARY FOR THE 104 00:03:54,000 --> 00:04:00,920 OPEN SESSION DETAILS. NEXT WE 105 00:04:00,920 --> 00:04:03,440 HAVE TO -- I WILL ASK FOR 106 00:04:03,440 --> 00:04:06,000 CORRECTIONS OR COMMENTS FROM THE 107 00:04:06,000 --> 00:04:08,680 MINUTES FROM THE WINTER 2022 108 00:04:08,680 --> 00:04:10,000 COUNCIL MEANING. COPIES WERE 109 00:04:10,000 --> 00:04:11,240 PROVIDED TO YOU IN ADVANCE OF 110 00:04:11,240 --> 00:04:18,680 THE MEETING. 111 00:04:18,680 --> 00:04:20,160 ANY QUESTIONS OR COMMENTS ABOUT 112 00:04:20,160 --> 00:04:21,880 THE MINUTES PLEASE RAISE YOUR 113 00:04:21,880 --> 00:04:23,720 HAND OR JUST UNMUTE. TRACY, I 114 00:04:23,720 --> 00:04:24,320 DON'T SEE ANY. 115 00:04:24,320 --> 00:04:27,160 >> GREAT. SO WITH THAT I'M 116 00:04:27,160 --> 00:04:29,920 SEEKING A MOTION FOR APPROVAL OF 117 00:04:29,920 --> 00:04:35,400 THE WINTER 2022 DRAFT MINUTES. A 118 00:04:35,400 --> 00:04:36,600 MOTION AND A SECOND FROM LAURA. 119 00:04:36,600 --> 00:04:38,760 THANK YOU. ALL IN FAVOR OF 120 00:04:38,760 --> 00:04:40,840 APPROVING THE MINUTES AS WRITTEN 121 00:04:40,840 --> 00:04:45,480 PLEASE RAISE YOUR HAND. 122 00:04:45,480 --> 00:04:47,880 EXCELLENT. 123 00:04:47,880 --> 00:04:50,640 OKAY. AND I CAN PUT YOUR HANDS 124 00:04:50,640 --> 00:04:54,280 DOWN, I THINK THEY CAPTURED TH 125 00:04:54,280 --> 00:04:56,040 THAT. ANY OPPOSED TO THE MINUTES 126 00:04:56,040 --> 00:05:03,360 AS WRITTEN? AND ANY ABSTENTIONS 127 00:05:03,360 --> 00:05:04,960 ALL RIGHT. WE HAVE APPROVAL OF 128 00:05:04,960 --> 00:05:05,920 THE MINUTES. THANK YOU VERY 129 00:05:05,920 --> 00:05:09,200 MUCH. 130 00:05:09,200 --> 00:05:18,040 >> GREAT. 131 00:05:18,040 --> 00:05:20,040 EXCELLENT. I'M BACK HOPEFULLY 132 00:05:20,040 --> 00:05:23,480 YOU CAN SEE ME, YE YE YES. MY SN 133 00:05:23,480 --> 00:05:24,480 WENT BLANK A MOMENT. THE NEXT 134 00:05:24,480 --> 00:05:26,600 ITEM ON THE AGENDA IS NIMH 135 00:05:26,600 --> 00:05:28,280 DIRECTOR'S REPORT. WHICH I WILL 136 00:05:28,280 --> 00:05:30,080 PRESENT. TRACY DID YOU RUN MY 137 00:05:30,080 --> 00:05:31,720 OWN SLIDES OR SOMEONE GOING TO 138 00:05:31,720 --> 00:05:32,120 RUN THEM THERE? 139 00:05:32,120 --> 00:05:35,760 >> I BELIEVE ALEX WAS RUNNING 140 00:05:35,760 --> 00:05:38,880 THE SLIDES. BUT IF YOU PREFER -- 141 00:05:38,880 --> 00:05:41,600 >> NO, IT'S FINE. ALEX WHY DON'T 142 00:05:41,600 --> 00:05:43,520 YOU GO AHEAD AND DO THAT BECAUSE 143 00:05:43,520 --> 00:05:45,400 I TRIED TO START POWERPOINT AND 144 00:05:45,400 --> 00:05:46,520 THE SCREEN WENT BLANK A MOMENT. 145 00:05:46,520 --> 00:05:55,520 >> LET ME KNOW WHEN YOU ARE ON. 146 00:05:55,520 --> 00:06:00,960 >> I CAN SEE THEM ON MY END. 147 00:06:00,960 --> 00:06:05,000 >> OKAY. I MIGHT HAVE THE WRONG 148 00:06:05,000 --> 00:06:07,720 -- THERE YOU GO. ALL RIGHT. 149 00:06:07,720 --> 00:06:09,160 WELL, AGAIN, WE WILL START OUT 150 00:06:09,160 --> 00:06:11,240 WITH MY DIRECTORS UPDATE FOR 151 00:06:11,240 --> 00:06:15,800 COUNCIL. NEXT SLIDE. THE AGENDA 152 00:06:15,800 --> 00:06:18,360 IS FAIRLY STRAIGHT FORE. WE WILL 153 00:06:18,360 --> 00:06:21,800 START WITH A VERY EXCITING 154 00:06:21,800 --> 00:06:23,880 FOLLOW-UP TO THE PRESIDENT'S 155 00:06:23,880 --> 00:06:24,800 STATEMENT, THEN WE WILL TALK 156 00:06:24,800 --> 00:06:28,040 ABOUT THE UNITY AGENDA WHICH 157 00:06:28,040 --> 00:06:30,400 INCLUDES MENTAL HEALTH POINT AND 158 00:06:30,400 --> 00:06:31,680 WHAT THAT MEANS FOR THE NATIONAL 159 00:06:31,680 --> 00:06:32,920 INSTITUTE OF MENTAL HEALTH. WE 160 00:06:32,920 --> 00:06:34,320 WILL ALSO TALK ABOUT 161 00:06:34,320 --> 00:06:35,920 INTERACTIONS WITH CONGRESS AND 162 00:06:35,920 --> 00:06:38,360 WITH THE WHITE HOUSE AND GIVE AN 163 00:06:38,360 --> 00:06:41,520 UPDATE AS TO OUR APPROPRIATIONS 164 00:06:41,520 --> 00:06:44,000 PROCESS AND THE BUDGET BOTH FOR 165 00:06:44,000 --> 00:06:45,520 THIS YEAR AND OUTLOOK INTO NEXT 166 00:06:45,520 --> 00:06:51,400 YEAR. NEXT WE WILL GO DETAIL 167 00:06:51,400 --> 00:06:53,360 SOME UPDATES FROM HHS AND NIH, 168 00:06:53,360 --> 00:06:56,920 GIVE YOU SOME NEWS FROM NIMH AND 169 00:06:56,920 --> 00:06:58,840 THEN WITH SCIENCE HIGHLIGHTS. IF 170 00:06:58,840 --> 00:07:01,480 YOU HAVE ANY QUESTIONS OR 171 00:07:01,480 --> 00:07:02,680 COMMENTS FEEL FREE TO ENTER THEM 172 00:07:02,680 --> 00:07:04,920 INTO THE CHAT AT ANY POINT. I 173 00:07:04,920 --> 00:07:05,920 MAY INTERRUPT MYSELF TO ANSWER 174 00:07:05,920 --> 00:07:07,720 THEM ALONG THE WAY OR I MAY 175 00:07:07,720 --> 00:07:09,840 HANDLE THEM AT THE END. CAN ALSO 176 00:07:09,840 --> 00:07:11,640 RAISE YOUR HAND IF YOU WOULD 177 00:07:11,640 --> 00:07:13,480 LIKE TO ASK WHEN WE COME ALONG 178 00:07:13,480 --> 00:07:23,920 THE WAY. START WITH THE I 179 00:07:23,920 --> 00:07:25,640 BELIEVE HAPPENED AFTER THE LAST 180 00:07:25,640 --> 00:07:28,760 MEETING MARCH 1, PRESIDENT BIDEN 181 00:07:28,760 --> 00:07:30,200 DELIVERED THE STATE OF THE UNION 182 00:07:30,200 --> 00:07:31,520 ADDRESS WHICH OUTLINED THE 183 00:07:31,520 --> 00:07:32,760 ADMINISTRATION PRIORITIES. 184 00:07:32,760 --> 00:07:35,080 DURING THE ADDRESS WE WERE 185 00:07:35,080 --> 00:07:36,120 PLEASED TO HEAR THE PRESIDENT 186 00:07:36,120 --> 00:07:37,920 ANNOUNCED A BIPARTISAN STRATEGY 187 00:07:37,920 --> 00:07:39,240 TO RESPOND TO NATIONAL MENTAL 188 00:07:39,240 --> 00:07:40,400 HEALTH AND SUBSTANCE USE 189 00:07:40,400 --> 00:07:41,760 DISORDER CRISIS AS PART OF HIS 190 00:07:41,760 --> 00:07:44,520 UNITY AGENDA. THAT WILL 191 00:07:44,520 --> 00:07:46,200 HOPEFULLY BE BIPARTISAN SUPPORT 192 00:07:46,200 --> 00:07:48,960 FOR AN EFFORT TO ADDRESS THE 193 00:07:48,960 --> 00:07:49,760 MENTAL HEALTH CRISIS IN THE 194 00:07:49,760 --> 00:07:53,800 UNITED STATES. 195 00:07:53,800 --> 00:07:55,440 THAT AGENDA INCLUDES THREE 196 00:07:55,440 --> 00:07:57,240 PILLARS. STRENGTHENING SYSTEM 197 00:07:57,240 --> 00:07:59,640 CAPACITY. CONNECTING AMERICANS 198 00:07:59,640 --> 00:08:00,800 TO MENTAL HEALTHCARE. AND 199 00:08:00,800 --> 00:08:03,680 SUPPORTING AMERICANS BY CREATING 200 00:08:03,680 --> 00:08:05,040 HEALTHY ENVIRONMENTS. EACH OF 201 00:08:05,040 --> 00:08:07,480 THESE PLANKS IS OUTLINED BY SO 202 00:08:07,480 --> 00:08:09,680 CALLED FAST FACTS BROCHURE THAT 203 00:08:09,680 --> 00:08:11,200 THE WHITE HOUSE PUT OUT 204 00:08:11,200 --> 00:08:12,240 IMMEDIATELY AFTER THE STATE OF 205 00:08:12,240 --> 00:08:14,880 THE UNION AND RECENTLY UPDATED. 206 00:08:14,880 --> 00:08:16,720 EACH OF THESE IS SUPPORTED BY 207 00:08:16,720 --> 00:08:19,120 EVIDENCE BASED APPROACHES, MANY 208 00:08:19,120 --> 00:08:20,600 OF THEM GREW OUT OF RESEARCH 209 00:08:20,600 --> 00:08:23,320 THAT WAS SUPPORTED BY THE NIMH. 210 00:08:23,320 --> 00:08:26,000 FOR EXAMPLE STRENGTHENING SYSTEM 211 00:08:26,000 --> 00:08:27,400 CAPACITY INCLUDES INCREASING OUR 212 00:08:27,400 --> 00:08:29,160 ABILITY TO GIVE MENTAL 213 00:08:29,160 --> 00:08:32,680 HEALTHCARE AN APPROPRIATE SET, 214 00:08:32,680 --> 00:08:33,280 INCREASING COLLABORATIVE CARE 215 00:08:33,280 --> 00:08:35,120 WHILE INCREASING TELEMENTAL 216 00:08:35,120 --> 00:08:36,360 HEALTH AND INCREASING MENTAL 217 00:08:36,360 --> 00:08:37,760 HEALTHCARE IN SCHOOLS. ALL WHICH 218 00:08:37,760 --> 00:08:39,880 HAS AN EVIDENCE BASE THAT GREW 219 00:08:39,880 --> 00:08:43,080 OUT OF NIMH FUNDING RESEARCH. 220 00:08:43,080 --> 00:08:45,040 THE LATEST VERSION OF THE UNITY 221 00:08:45,040 --> 00:08:47,440 AGENDA, UPDATED JUST A WEEK OR 222 00:08:47,440 --> 00:08:50,520 SO AGO. ESTABLISHES A FEDERAL 223 00:08:50,520 --> 00:08:52,320 RESEARCH ACTION PLAN. THAT 224 00:08:52,320 --> 00:08:53,520 RESEARCH ACTION PLAN WILL BE 225 00:08:53,520 --> 00:08:54,520 SPEARHEADED BY THE WHITE HOUSE 226 00:08:54,520 --> 00:08:57,760 OFFICE OF SCIENCE TECHNOLOGY AND 227 00:08:57,760 --> 00:08:59,240 POLICY BUT WILL INVOLVE NIMH AND 228 00:08:59,240 --> 00:09:01,960 OTHER AGENCIES WHICH HAVE A ROLE 229 00:09:01,960 --> 00:09:03,560 TO PLAY IN RESEARCH RELATED TO 230 00:09:03,560 --> 00:09:05,440 MENTAL HEALTH. I'M PLEASED IN 231 00:09:05,440 --> 00:09:07,200 PARTICULAR TO SEE THE DEPARTMENT 232 00:09:07,200 --> 00:09:10,520 OF EDUCATION, AS WELL AS OTHER 233 00:09:10,520 --> 00:09:12,200 PLAYERS THAT HAVE A ROLE TO PLAY 234 00:09:12,200 --> 00:09:14,000 IN ADDRESSING THE MENTAL HEALTH 235 00:09:14,000 --> 00:09:16,120 CRISIS BUT HERETOFORE HAVE NOT 236 00:09:16,120 --> 00:09:18,280 MADE MAJOR INVESTMENTS IN MENTAL 237 00:09:18,280 --> 00:09:19,720 HEALTH RESEARCH. IN ADDITION TO 238 00:09:19,720 --> 00:09:22,440 THE FEDERAL RESEARCH ACTION PLAN 239 00:09:22,440 --> 00:09:25,640 PROCESS GETTING UNDERWAY EVEN AS 240 00:09:25,640 --> 00:09:29,000 WE SPEAK, THE PRESIDENT'S BUDGET 241 00:09:29,000 --> 00:09:31,360 REQUEST FOR NIMH INCLUDES 242 00:09:31,360 --> 00:09:34,160 RESEARCH FUNDING FOR AREAS THAT 243 00:09:34,160 --> 00:09:35,880 WERE NOTED IN THE UNITY AGENDA 244 00:09:35,880 --> 00:09:38,840 NEEDING ADDITIONAL DATA. THIS 245 00:09:38,840 --> 00:09:40,160 INCLUDES $5 MILLION PROPOSED FOR 246 00:09:40,160 --> 00:09:41,560 RESEARCH FOR INNOVATIVE 247 00:09:41,560 --> 00:09:44,600 TREATMENT MODELS THAT WE WILL 248 00:09:44,600 --> 00:09:46,800 USE TO CONTINUE OUR INVESTMENTS 249 00:09:46,800 --> 00:09:48,480 AND ENLARGE OUR INVESTMENTS AND 250 00:09:48,480 --> 00:09:49,880 IMPLEMENTATION SCIENCE AND 251 00:09:49,880 --> 00:09:53,880 SERVICES RESEARCH AS WELL AS 252 00:09:53,880 --> 00:09:55,120 ADDITIONAL $5 MILLION PROPOSED 253 00:09:55,120 --> 00:09:57,280 TO FUND RESEARCH ON MENTAL 254 00:09:57,280 --> 00:09:59,920 HEALTH IMPACT OF SOCIAL MEDIA. 255 00:09:59,920 --> 00:10:01,680 NIMH IS GEARING UP TO BE ABLE TO 256 00:10:01,680 --> 00:10:03,160 ENSURE THAT WE USE THAT MONEY 257 00:10:03,160 --> 00:10:05,000 WISELY, SHOULD IT BE ALLOCATED 258 00:10:05,000 --> 00:10:07,360 BY CONGRESS. AND IMPORTANTLY, 259 00:10:07,360 --> 00:10:08,880 INVESTING IN THESE AREAS EVEN 260 00:10:08,880 --> 00:10:10,600 WHILE WAITING FOR ADDITIONAL 261 00:10:10,600 --> 00:10:11,880 RESOURCES TO BE ABLE TO DEVOTE 262 00:10:11,880 --> 00:10:18,000 TO THEM. NEXT SLIDE. LET'S TALK 263 00:10:18,000 --> 00:10:19,240 ABOUT INTERACTIONS WITH CONGRESS 264 00:10:19,240 --> 00:10:24,200 AND WHITE HOUSE. ON FEBRUARY 265 00:10:24,200 --> 00:10:26,640 16TH, 2022 RIGHT THROUGH APRIL 266 00:10:26,640 --> 00:10:27,640 5, 2022, SO RIGHT AROUND THE 267 00:10:27,640 --> 00:10:30,080 TIME OF OUR LAST MEETING AND 268 00:10:30,080 --> 00:10:32,320 CONTINUING RIGHT UP UNTIL 269 00:10:32,320 --> 00:10:34,360 RECENTLY, NIMH STAFF HAS BEEN 270 00:10:34,360 --> 00:10:35,920 ENGAGING WITH NUMBER OF 271 00:10:35,920 --> 00:10:36,760 DIFFERENT REPRESENTATIVES FROM 272 00:10:36,760 --> 00:10:38,320 CONGRESS INCLUDING HERE YOU CAN 273 00:10:38,320 --> 00:10:41,560 SEE STAFF SENATOR ROY BLOUNT'S 274 00:10:41,560 --> 00:10:43,520 OFFICE FROM REPRESENTATIVE 275 00:10:43,520 --> 00:10:45,560 KIRKPATRICK'S OFFICE, I MYSELF 276 00:10:45,560 --> 00:10:47,160 SPOKE WITH THE FRIENDS OF 277 00:10:47,160 --> 00:10:47,880 NATIONAL INSTITUTE OF MENTAL 278 00:10:47,880 --> 00:10:49,520 HEALTH AND CONGRESSIONAL MENTAL 279 00:10:49,520 --> 00:10:52,960 HEALTH CAUCUS IN MARCH, NIMH 280 00:10:52,960 --> 00:10:54,840 ADVANCES AND PROGRAMS EARLY 281 00:10:54,840 --> 00:10:57,800 PSYCHOSIS RESEARCH AND IN APRIL 282 00:10:57,800 --> 00:11:00,120 I REPRESENTED DON BEYER ON 283 00:11:00,120 --> 00:11:01,200 SUICIDE PREVENTION RESEARCH. AS 284 00:11:01,200 --> 00:11:02,640 YOU CAN SEE FROM THE LIST THERE 285 00:11:02,640 --> 00:11:04,720 IS INTEREST IN MENTAL HEALTH IN 286 00:11:04,720 --> 00:11:06,880 CONGRESS AND THAT INTEREST IS 287 00:11:06,880 --> 00:11:08,920 DECIDEDLY BIPARTISAN AND WE ARE 288 00:11:08,920 --> 00:11:10,080 HOPING THAT THIS WILL MEAN 289 00:11:10,080 --> 00:11:11,760 INCREASE ATTENTION AND INCREASE 290 00:11:11,760 --> 00:11:12,920 RESOURCES FOR RESEARCH AND CARE 291 00:11:12,920 --> 00:11:14,720 FOR MENTAL HEALTH IN THE UNITED 292 00:11:14,720 --> 00:11:18,840 STATES. NEXT SLIDE. CONTINUING 293 00:11:18,840 --> 00:11:22,400 THROUGH APRIL AND MAY, I MET 294 00:11:22,400 --> 00:11:25,280 WITH REPRESENTATIVE DAVID TRONE 295 00:11:25,280 --> 00:11:26,760 TO PARTICIPANT VIEW UPDATES ON 296 00:11:26,760 --> 00:11:28,760 SUICIDE PREVENTION COVID-19 297 00:11:28,760 --> 00:11:31,200 RESEARCH. PRINT 29, 298 00:11:31,200 --> 00:11:32,080 APPROPRIATIONS PROCESS I MET 299 00:11:32,080 --> 00:11:33,640 WITH THE APPROPRIATION CLERKS TO 300 00:11:33,640 --> 00:11:35,080 DISCUSS NIMH RESEARCH AND THE 301 00:11:35,080 --> 00:11:36,080 BUDGET REQUEST FOR THE INSTITUTE 302 00:11:36,080 --> 00:11:42,360 AND IN MAY ALONG WITH DR. NORA 303 00:11:42,360 --> 00:11:45,560 VOLKOW NIMH STAFF MET WITH 304 00:11:45,560 --> 00:11:48,160 HEALTH LABOR AND PENSIONS AND 305 00:11:48,160 --> 00:11:50,720 SENATOR CHRIS MURPHY'S STAFF TO 306 00:11:50,720 --> 00:11:53,240 DISCUSS LEGISLATIVE PROPOSALS. 307 00:11:53,240 --> 00:11:55,400 FINALLY I TESTIFIED TWICE SINCE 308 00:11:55,400 --> 00:11:59,040 OUR LAST MEETING BEFORE SENATE 309 00:11:59,040 --> 00:11:59,920 COMMITTEES, SENATE COMMITTEE ON 310 00:11:59,920 --> 00:12:02,040 HEALTH EDUCATION LABOR AND 311 00:12:02,040 --> 00:12:03,120 PENSIONS HAD AUTHORIZATION 312 00:12:03,120 --> 00:12:05,080 COMMITTEE TO LOOK INTO 313 00:12:05,080 --> 00:12:07,080 AUTHORIZING AND REAUTHORIZING 314 00:12:07,080 --> 00:12:08,800 LEGISLATION THAT THERE 315 00:12:08,800 --> 00:12:10,040 STRENGTHEN FEDERAL MENTAL HEALTH 316 00:12:10,040 --> 00:12:11,760 AND SUBSTANCE USE PROGRAMS AND 317 00:12:11,760 --> 00:12:13,920 REQUEST I BE WILL TO PROVIDE 318 00:12:13,920 --> 00:12:15,080 COMMENTARY ON EVIDENCE BRACED 319 00:12:15,080 --> 00:12:16,960 APPROACHES TO DOING SO. ON MAY 320 00:12:16,960 --> 00:12:19,280 17 REMOTELY I TESTIFIED BEFORE 321 00:12:19,280 --> 00:12:20,160 THE SENATE APPROPRIATION 322 00:12:20,160 --> 00:12:21,920 SUBCOMMITTEE ON LABOR HEALTH AND 323 00:12:21,920 --> 00:12:23,600 HUMAN SERVICES EDUCATION RELATED 324 00:12:23,600 --> 00:12:26,760 AGENCIES ON THE PROPOSED FISCAL 325 00:12:26,760 --> 00:12:28,120 YEAR 2023 BUDGET FOR NIH. LET ME 326 00:12:28,120 --> 00:12:29,720 SAY IN BOTH HEARINGS THERE WAS A 327 00:12:29,720 --> 00:12:31,400 LOT OF INTEREST IN UNDERSTANDING 328 00:12:31,400 --> 00:12:32,960 THE MENTAL HEALTH IMPACT OF 329 00:12:32,960 --> 00:12:34,960 COVID AND THERE WAS ALSO 330 00:12:34,960 --> 00:12:36,880 INTEREST IN PARTICULAR AROUND 331 00:12:36,880 --> 00:12:38,120 MENTAL HEALTH IN YOUTH. LOOKING 332 00:12:38,120 --> 00:12:39,720 FOR EVIDENCE BASED APPROACHES 333 00:12:39,720 --> 00:12:42,920 AND SUPPORT RESEARCH INTO 334 00:12:42,920 --> 00:12:43,480 EXPANDING AVAILABILITY OF 335 00:12:43,480 --> 00:12:47,160 EVIDENCE BASED APPROACHES. WE 336 00:12:47,160 --> 00:12:48,560 HAVE ALSO BEEN ENGAGING WITH THE 337 00:12:48,560 --> 00:12:49,680 WHITE HOUSE OFFICE OF SCIENCE 338 00:12:49,680 --> 00:12:52,360 AND TECHNOLOGY POLICY WHICH AS I 339 00:12:52,360 --> 00:12:55,000 SAID BEFORE LISTEN RESPONSIBLE 340 00:12:55,000 --> 00:12:57,400 FOR GUIDING THE FEDERAL RESEARCH 341 00:12:57,400 --> 00:13:01,320 PLAN. ON MAY 19 NIMH DEPUTY 342 00:13:01,320 --> 00:13:04,200 DIRECTOR SHELLEY AVENEVOLI 343 00:13:04,200 --> 00:13:06,000 PARTICIPATED IN A FIRE SIDE CHAT 344 00:13:06,000 --> 00:13:07,840 TO DISCUSS ADOLESCENT BRAIN 345 00:13:07,840 --> 00:13:09,000 DEVELOPMENT ESPECIALLY STRESS 346 00:13:09,000 --> 00:13:11,840 AND COVID-19 PANDEMIC AND SOCIAL 347 00:13:11,840 --> 00:13:13,840 MEDIA. SHE WAS JOINED THERE BY 348 00:13:13,840 --> 00:13:16,760 DEPUTY DIRECTOR OF NIDA, DR. 349 00:13:16,760 --> 00:13:21,640 WILSON CONGRESS LY COKE LYNN. LK 350 00:13:21,640 --> 00:13:22,160 ABOUT APPROPRIATIONS AND 351 00:13:22,160 --> 00:13:25,640 BUDGETS. MARCH 15, AS MOST OF 352 00:13:25,640 --> 00:13:27,520 YOU KNOW PRESIDENT BIDEN SIGNED 353 00:13:27,520 --> 00:13:29,000 THE CONSOLIDATED APPROPRIATIONS 354 00:13:29,000 --> 00:13:32,440 ACT OF 2022, WHICH GAVE US OUR 355 00:13:32,440 --> 00:13:35,120 2022 FISCAL YEAR 2022 BUDGET. 356 00:13:35,120 --> 00:13:39,320 THAT INCLUDED $2.2 BILLION 357 00:13:39,320 --> 00:13:42,040 BUDGET FOR NIMH, WHICH 358 00:13:42,040 --> 00:13:43,160 REPRESENTS HEALTHY INCREASE OVER 359 00:13:43,160 --> 00:13:46,640 LAST YEAR. INCLUDED IN THAT 360 00:13:46,640 --> 00:13:49,320 2.2 BILLION WAS $20 MILLION 361 00:13:49,320 --> 00:13:51,400 EXTRA INCREASE ABOVE AND BEYOND 362 00:13:51,400 --> 00:13:52,560 WHAT OTHERWISE WOULD HAVE GOTTEN 363 00:13:52,560 --> 00:13:54,160 FROM THE GENERAL INCREASE IN THE 364 00:13:54,160 --> 00:13:55,400 NIH BUDGET. IN ORDER TO EXPAND 365 00:13:55,400 --> 00:13:56,960 RESEARCH ON THE IMPACT OF COVID 366 00:13:56,960 --> 00:13:59,840 THE COVID-19 PANDEMIC ON MENTAL 367 00:13:59,840 --> 00:14:00,600 HEALTH YOU HAVE ALREADY SEEN A 368 00:14:00,600 --> 00:14:03,120 NUMBER OF COVID-19 RELATED 369 00:14:03,120 --> 00:14:04,600 MENTAL HEALTH GRANTS IN PRIOR 370 00:14:04,600 --> 00:14:07,000 COUNCIL ROUNDS AS WELL AS 371 00:14:07,000 --> 00:14:08,560 SEVERAL WE ARE APPROVING THIS 372 00:14:08,560 --> 00:14:09,840 COUNCIL ROUND BUT ALSO AN 373 00:14:09,840 --> 00:14:12,920 EMERGENCY RFA TO RECRUIT MORE 374 00:14:12,920 --> 00:14:16,280 RESEARCH IN THAT AREA. THAT RFA 375 00:14:16,280 --> 00:14:17,920 WILL BE APPLICATION FROM THAT 376 00:14:17,920 --> 00:14:20,280 RFA WILL BE REVIEWED IN THE NEXT 377 00:14:20,280 --> 00:14:23,800 FEW WEEKS. AND WE WILL BE 378 00:14:23,800 --> 00:14:26,360 PRESENTING IT BY -- FOR 379 00:14:26,360 --> 00:14:28,080 DISCUSSION IN OUR AUGUST VIRTUAL 380 00:14:28,080 --> 00:14:32,360 COUNCIL MEETING. ALSO INCLUDES 381 00:14:32,360 --> 00:14:33,360 $1 BILLION TO LAUNCH ADVANCE 382 00:14:33,360 --> 00:14:37,400 RESEARCH PROJECTS AGENCY FOR 383 00:14:37,400 --> 00:14:37,960 HEALTH AT NIH, SOMETHING WE 384 00:14:37,960 --> 00:14:39,560 DISCUSSED HERE WITH YOU IN THE 385 00:14:39,560 --> 00:14:40,960 PAST. THIS IS A SEPARATE AGENCY 386 00:14:40,960 --> 00:14:43,640 LOCATED AT THE NIH BUT REPORT 387 00:14:43,640 --> 00:14:46,560 DIRECTLY TO THE SECRETARY. AND 388 00:14:46,560 --> 00:14:49,040 WE EXPECT AND HOPE THAT ARPA H 389 00:14:49,040 --> 00:14:51,080 WILL COLLABORATE WITH NUMBER OF 390 00:14:51,080 --> 00:14:52,600 NIH INSTITUTES INCLUDING NIMH IN 391 00:14:52,600 --> 00:14:54,360 ORDER TO ADVANCE PROJECTS IN 392 00:14:54,360 --> 00:14:56,240 WAYS THAT WE CAN'T DO IT ON OUR 393 00:14:56,240 --> 00:14:58,320 OWN HERE AS AN INSTITUTE BUT 394 00:14:58,320 --> 00:15:01,560 THAT CAN INCREASE THE RAPIDITY 395 00:15:01,560 --> 00:15:03,040 WHICH REACH PUBLIC HEALTH 396 00:15:03,040 --> 00:15:05,720 IMPACT. NEXT SLIDE. THIS THEN 397 00:15:05,720 --> 00:15:09,000 IS THE CURVE OF THE BUDGET 398 00:15:09,000 --> 00:15:10,600 APPROPRIATIONS FOR 2010 THROUGH 399 00:15:10,600 --> 00:15:13,280 2022. YOU CAN SO E WE CONTINUE 400 00:15:13,280 --> 00:15:15,080 TO HAVE STEADY INCREASE IN OUR 401 00:15:15,080 --> 00:15:19,440 BUDGET STARTED IN 2016. WE HAVE 402 00:15:19,440 --> 00:15:22,560 PUT FOR YEARS 2018 THROUGH 2022 403 00:15:22,560 --> 00:15:23,920 A LITTLE PURPLE SMUDGE AT THE 404 00:15:23,920 --> 00:15:26,000 END OF THAT LINE, THAT 405 00:15:26,000 --> 00:15:27,400 REPRESENTS THE APPROPRIATIONS 406 00:15:27,400 --> 00:15:28,960 THAT ARE OUTSIDE OF THE NORMAL 407 00:15:28,960 --> 00:15:30,880 APPROPRIATION PROCESS BY GIVING 408 00:15:30,880 --> 00:15:33,720 TO NIMH AS PART OF THE 21ST 409 00:15:33,720 --> 00:15:35,040 CENTURY CURES ACT WHICH PASSED 410 00:15:35,040 --> 00:15:38,520 AT THE END OF 2016 AND WHICH 411 00:15:38,520 --> 00:15:40,040 SUPPLIES DOLLARS FOR THE BRAIN 412 00:15:40,040 --> 00:15:42,040 INITIATIVE, THAT IS NOT ALL THE 413 00:15:42,040 --> 00:15:43,760 DOLLARS THE BRAIN INITIATIVE 414 00:15:43,760 --> 00:15:46,600 BUDGET HAS, THERE IS ADDITIONAL 415 00:15:46,600 --> 00:15:48,800 APPROXIMATELY $100 MILLION OR SO 416 00:15:48,800 --> 00:15:50,040 OF BASE NIMH BUDGET WHICH GOES 417 00:15:50,040 --> 00:15:50,760 TO BRAIN AT DIRECTION OF 418 00:15:50,760 --> 00:15:56,280 CONGRESS. AS A RESULT OF THESE 419 00:15:56,280 --> 00:15:56,880 BUDGET INCREASES WE HAVE BEEN 420 00:15:56,880 --> 00:16:02,360 ABLE TO MAINTAIN A RELATIVELY 421 00:16:02,360 --> 00:16:04,400 MODEST SUCCESS RATE, THIS YEAR 422 00:16:04,400 --> 00:16:06,280 THAT SUCCESS RATE WITH OUR 423 00:16:06,280 --> 00:16:08,160 INCREASE IN 2022 IS ESTIMATED TO 424 00:16:08,160 --> 00:16:12,160 GO UP TO APPROXIMATELY 24%. WE 425 00:16:12,160 --> 00:16:15,760 RECEIVED ESTIMATED WE WILL 426 00:16:15,760 --> 00:16:17,400 RECEIVE 2834 APPLICATIONS, A 427 00:16:17,400 --> 00:16:19,120 SLIGHT DECREASE FROM 2021 WE SEE 428 00:16:19,120 --> 00:16:21,880 A LOT OF APPLICATIONS POSSIBLY 429 00:16:21,880 --> 00:16:23,920 RESULTING FROM THE FACT THAT 430 00:16:23,920 --> 00:16:25,440 MANY INDIVIDUALS WERE OUTSIDE OF 431 00:16:25,440 --> 00:16:27,440 THEIR LABS WORKING REMOTESLY 432 00:16:27,440 --> 00:16:29,880 WRITING GRANTS TO NIH DURING THE 433 00:16:29,880 --> 00:16:31,880 COVID PANDEMIC AND THAT HAS 434 00:16:31,880 --> 00:16:34,880 RESULTED IN A SLIGHT DECREASE 435 00:16:34,880 --> 00:16:36,320 FOR 2022. BUT BECAUSE OF OUR 436 00:16:36,320 --> 00:16:37,880 BUDGET WE ARE ABLE TO INCREASE 437 00:16:37,880 --> 00:16:39,520 THE NUMBER OF GRANTS THAT WE 438 00:16:39,520 --> 00:16:41,920 ANTICIPATE AWARDING THIS FISCAL 439 00:16:41,920 --> 00:16:44,160 YEAR TO CLOSE TO 700 TOTAL 440 00:16:44,160 --> 00:16:46,720 GRANTS TO INCLUDE THE CURES 441 00:16:46,720 --> 00:16:48,040 AWARD. NOTE FOR THOSE OF YOU IN 442 00:16:48,040 --> 00:16:51,120 THE AUDIENCE WHO SAY MY GRANT 443 00:16:51,120 --> 00:16:52,120 GOT 16 PERCENTILE AND NOT 444 00:16:52,120 --> 00:16:54,320 GETTING FUNDED. FOR MANY REASONS 445 00:16:54,320 --> 00:16:55,720 THE SUCCESS RATE DOES NOT EQUAL 446 00:16:55,720 --> 00:16:58,360 THE PERCENTILE RATE WE REACH. 447 00:16:58,360 --> 00:17:01,040 FIRST AND FOREMOST NIMH GRANTS 448 00:17:01,040 --> 00:17:02,440 DO EXCEPTIONALLY WELL IN 449 00:17:02,440 --> 00:17:03,840 COMPETITION WITH GRANTS AND 450 00:17:03,840 --> 00:17:06,320 OTHER AGENCIES SO WE FIND THAT 451 00:17:06,320 --> 00:17:08,200 TYPICALLY WELL MORE THAN 10% OF 452 00:17:08,200 --> 00:17:11,320 GRANTS ARE SCORED IN THE TOP 10 453 00:17:11,320 --> 00:17:14,120 PERCENTILE OVERALL. SECONDLY, 454 00:17:14,120 --> 00:17:17,280 THE 24% FIGURE INCLUDES BRAIN 455 00:17:17,280 --> 00:17:20,200 GRANTS, INCLUDES NUMBER OF OTHER 456 00:17:20,200 --> 00:17:22,160 GRANTS FOR EXAMPLE THROUGH 457 00:17:22,160 --> 00:17:22,720 RFAs AND CLINICAL TRIALS 458 00:17:22,720 --> 00:17:26,000 RFAs AS WELL AS DEDICATED RFAS 459 00:17:26,000 --> 00:17:26,920 IN GAP AREAS, WHICH HAVE HIGHER 460 00:17:26,920 --> 00:17:33,880 SUCCESS RATE. SO THAT IS OUR 461 00:17:33,880 --> 00:17:35,920 BUDGET APPROPRIATIONS. LET'S 462 00:17:35,920 --> 00:17:40,880 MOVE ON TO NEWS FROM HHS AND 463 00:17:40,880 --> 00:17:43,600 NIH. MARCH 2, 2022, THE HEALTHY 464 00:17:43,600 --> 00:17:45,240 HUMAN -- HEALTH AND HUMAN 465 00:17:45,240 --> 00:17:47,920 SERVICES SECRETARY JAVIER 466 00:17:47,920 --> 00:17:48,960 BECERRA ANNOUNCE AD NATIONAL 467 00:17:48,960 --> 00:17:50,480 TOUR TO STRENGTHEN MENTAL HEALTH 468 00:17:50,480 --> 00:17:51,920 AS PART OF HHS RESPONSE TO THE 469 00:17:51,920 --> 00:17:55,320 MENTAL HEALTH CRISIS. SECRETARY 470 00:17:55,320 --> 00:17:57,200 BECERRA VISITED A NUMBER OF 471 00:17:57,200 --> 00:17:59,800 LOCATIONS THROUGHOUT THE COUNTRY 472 00:17:59,800 --> 00:18:01,840 VISITING PLACES WHERE MENTAL 473 00:18:01,840 --> 00:18:03,160 HEALTH IS DELIVERED INCLUDING 474 00:18:03,160 --> 00:18:05,280 SCHOOLS AND INCLUDING CLINICS. 475 00:18:05,280 --> 00:18:07,640 AND EMPHASIZING THE NEED TO 476 00:18:07,640 --> 00:18:09,000 FOCUS ON MENTAL HEALTH AS WE 477 00:18:09,000 --> 00:18:10,040 MOVE FORWARD AS A NATION AFTER 478 00:18:10,040 --> 00:18:15,520 THE PANDEMIC. HHS ALSO AS I 479 00:18:15,520 --> 00:18:19,320 MENTIONED FORMALLY ESTABLISHED 480 00:18:19,320 --> 00:18:23,120 ARPA H AND WE RECENTLY RECRUITED 481 00:18:23,120 --> 00:18:24,880 TO NIH ADAM RUSSELL WHO HAS BEEN 482 00:18:24,880 --> 00:18:27,800 APPOINTED TO SERVE AS AGENCY 483 00:18:27,800 --> 00:18:29,000 ACTING DEPUTY DIRECTOR. DR. 484 00:18:29,000 --> 00:18:31,760 RUSSELL AS WELL AS OTHER MEMBERS 485 00:18:31,760 --> 00:18:34,520 OF THE NIH OFFICE OF THE 486 00:18:34,520 --> 00:18:36,640 DIRECTOR HAVE BEEN BUSY 487 00:18:36,640 --> 00:18:38,440 ESTABLISHING THE ADMINISTRATIVE 488 00:18:38,440 --> 00:18:40,960 STRUCTURE NECESSARY TO SUPPORT 489 00:18:40,960 --> 00:18:42,920 THE ARPA H ENDEAVOR WHILE WE 490 00:18:42,920 --> 00:18:46,160 AWAIT APPOINTMENT OF A DIRECTOR 491 00:18:46,160 --> 00:18:48,480 OF ARPA H AND THAT APPOINTMENT 492 00:18:48,480 --> 00:18:49,520 WILL BE -- THAT IS A 493 00:18:49,520 --> 00:18:51,920 PRESIDENTIAL APPOINTMENT SO WE 494 00:18:51,920 --> 00:18:53,240 AWAIT WORD FROM THE WHITE HOUSE 495 00:18:53,240 --> 00:18:58,680 WHO THAT MIGHT BE. 496 00:18:58,680 --> 00:19:00,840 AT NIH, BITTERSWEET NEWS AS DR. 497 00:19:00,840 --> 00:19:02,480 NED SHARPLESS, WHO HAS BEEN A 498 00:19:02,480 --> 00:19:05,000 STRONG PARTNER OF NIMH HELPING 499 00:19:05,000 --> 00:19:08,640 ENSURE SUCCESS OF THE CLINICAL 500 00:19:08,640 --> 00:19:11,040 CENTER, AND IN OTHER TRANS-NIH 501 00:19:11,040 --> 00:19:12,040 INITIATIVE, NED STEPPED DOWN 502 00:19:12,040 --> 00:19:15,280 FROM HIS ROLE AS DIRECTOR OF THE 503 00:19:15,280 --> 00:19:17,360 NATIONAL CANCER INSTITUTE AND 504 00:19:17,360 --> 00:19:20,160 ANOTHER FRIEND OF NIMH DOUG LOWY 505 00:19:20,160 --> 00:19:21,400 WHO PREVIOUSLY ON SEVERAL 506 00:19:21,400 --> 00:19:22,520 OCCASIONS SERVED AS THE ACTING 507 00:19:22,520 --> 00:19:24,840 NCI DIRECTOR HAS BEEN NAMED AS 508 00:19:24,840 --> 00:19:26,360 ACTING DIRECTOR AGAIN WHILE WE 509 00:19:26,360 --> 00:19:27,680 WAIT A PRESIDENTSIAL APPOINTMENT 510 00:19:27,680 --> 00:19:32,240 TO REPLACE DR. SHARPLESS. 511 00:19:32,240 --> 00:19:35,320 FINALLY I WANT TO NOTE FROM NIH 512 00:19:35,320 --> 00:19:37,480 WIDE PERSPECTIVE I WANT TO NOTE 513 00:19:37,480 --> 00:19:38,880 NIH WIDE DIVERSITY EQUITY 514 00:19:38,880 --> 00:19:43,840 INCLUSION AND ACCESSIBILITY 515 00:19:43,840 --> 00:19:44,480 CONTINUE. FEBRUARY 1ST NIH 516 00:19:44,480 --> 00:19:47,040 RELEASED A DRAFT NIH WIDE DEIA 517 00:19:47,040 --> 00:19:48,400 STRATEGIC PLAN FOR PUBLIC 518 00:19:48,400 --> 00:19:50,480 COMMENT AND MARCH 17TH NIH 519 00:19:50,480 --> 00:19:52,960 ISSUED ITS NEW TRIBAL 520 00:19:52,960 --> 00:19:55,160 CONSULTATION POLICY WHICH 521 00:19:55,160 --> 00:19:57,440 DICTATES THE FORM AND CONTENT OF 522 00:19:57,440 --> 00:19:58,680 CONSULTATIONS WE DO WITH NATIVE 523 00:19:58,680 --> 00:20:02,880 AMERICAN AND ALASKA NATIVE 524 00:20:02,880 --> 00:20:04,760 TRIBES AS WHEN RESEARCH WAS 525 00:20:04,760 --> 00:20:06,160 SIGNIFICANT COMPONENTS AND 526 00:20:06,160 --> 00:20:10,880 TRIBAL LANDS USING TRIBAL 527 00:20:10,880 --> 00:20:12,360 CITIZENS, WE NEED TO FOLLOW TO 528 00:20:12,360 --> 00:20:15,000 ENSURE THAT THAT WORK IS DONE IN 529 00:20:15,000 --> 00:20:16,640 AN ETHICAL WAY WITH ACCEPTANCE 530 00:20:16,640 --> 00:20:17,760 OF TRIBAL LEADERSHIP. NEXT 531 00:20:17,760 --> 00:20:23,200 SLIDE. ONE MORE PIECE OF NIH 532 00:20:23,200 --> 00:20:24,680 WIDE NEWS. THE NIH CLIMATE 533 00:20:24,680 --> 00:20:26,480 CHANGE AND HEALTH INITIATIVE 534 00:20:26,480 --> 00:20:28,920 STRATEGIC FRAMEWORK WAS PUB 535 00:20:28,920 --> 00:20:29,920 ACCOMPLISHED FEBRUARY 7 -- 536 00:20:29,920 --> 00:20:32,440 PUBLISHED FEBRUARY 7. NIH 537 00:20:32,440 --> 00:20:33,720 PARTICIPATE IN NIH WIDE PROGRAM 538 00:20:33,720 --> 00:20:36,120 FOCUSED ON CLIMATE CHANGE AND 539 00:20:36,120 --> 00:20:39,120 HEALTH LED BY NIEHS BUT ATTEMPTS 540 00:20:39,120 --> 00:20:40,640 TO UNDERSTAND THE HEALTH IMPACT 541 00:20:40,640 --> 00:20:44,800 OF CL CLIMATE CHANGE AND DEVELOP 542 00:20:44,800 --> 00:20:46,280 APPROACHES TO MODERATE THOSE 543 00:20:46,280 --> 00:20:52,960 IMPACTS. NEXT SLIDE. NEWS IN 544 00:20:52,960 --> 00:20:54,480 THE HEAL INITIATIVE HELPING TO 545 00:20:54,480 --> 00:20:56,960 END ADDICTION LONG TERM 546 00:20:56,960 --> 00:21:00,160 INITIATIVE, CONGRESSIONALLY 547 00:21:00,160 --> 00:21:01,520 FUNDED, PROGRAM TO TRY TO REDUCE 548 00:21:01,520 --> 00:21:04,320 IMPACT OF THE OPIOID EPIDEMIC 549 00:21:04,320 --> 00:21:05,480 HELD AN INVESTIGATOR MEETING, 550 00:21:05,480 --> 00:21:06,880 THE THIRD INVESTIGATOR MEETING 551 00:21:06,880 --> 00:21:11,440 ON MAY 11 AND 12TH WHICH NOTED 552 00:21:11,440 --> 00:21:13,440 PROGRESS ACHIEVED THE PAST YEAR 553 00:21:13,440 --> 00:21:14,320 INCLUDING TECHNOLOGY BASED 554 00:21:14,320 --> 00:21:16,960 THERAPIES FOR PAIN MANAGEMENT 555 00:21:16,960 --> 00:21:20,480 AND DISCUSSED FUTURE DIRECTIONS 556 00:21:20,480 --> 00:21:21,240 FOR THE INITIATIVE. ANOTHER 557 00:21:21,240 --> 00:21:23,720 EFFORT IMPORTANT FOR THE NIMH, 558 00:21:23,720 --> 00:21:26,000 MASH 17TH ALL OF US RELEASED ITS 559 00:21:26,000 --> 00:21:28,520 FIRST GENOMIC DATA SET, NEARLY 560 00:21:28,520 --> 00:21:29,920 100,000 GENOME SEQUENCE 561 00:21:29,920 --> 00:21:31,200 INDIVIDUALS PARTICIPATING IN THE 562 00:21:31,200 --> 00:21:32,960 PROGRAM. ABOUT 50% OF THAT DATA 563 00:21:32,960 --> 00:21:33,880 ARE FROM INDIVIDUALS WHO 564 00:21:33,880 --> 00:21:35,400 IDENTIFY WITH RACIAL OR ETHNIC 565 00:21:35,400 --> 00:21:37,000 GROUPS THAT HAVE BEEN 566 00:21:37,000 --> 00:21:38,120 HISTORICALLY UNDER-REPRESENTED 567 00:21:38,120 --> 00:21:39,480 IN BIOMEDICAL RESEARCH SO IT 568 00:21:39,480 --> 00:21:40,880 REPRESENTS A TREMENDOUS 569 00:21:40,880 --> 00:21:42,960 OPPORTUNITY TO ENSURE THAT OUR 570 00:21:42,960 --> 00:21:44,400 GENETIC INFORMATION THAT WE HAVE 571 00:21:44,400 --> 00:21:47,920 BEEN GETTING, GENETIC DATA CAN 572 00:21:47,920 --> 00:21:49,400 BE USEFUL FOR FRANKLY ALL OF US. 573 00:21:49,400 --> 00:21:52,240 THE ALL OF US PROGRAM CONTINUES 574 00:21:52,240 --> 00:21:54,720 TO RELEASE DATA AND CONTINUES TO 575 00:21:54,720 --> 00:21:56,200 IMPROVE USER INTERFACES THAT 576 00:21:56,200 --> 00:21:58,400 ALLOW INVESTIGATORS TO QUERY 577 00:21:58,400 --> 00:21:59,760 THAT DATA AND ENCOURAGE THOSE OF 578 00:21:59,760 --> 00:22:00,640 YOU WITH INTEREST IN DATA 579 00:22:00,640 --> 00:22:03,320 SCIENCE TO EXPLORE THE 580 00:22:03,320 --> 00:22:04,960 OPPORTUNITIES THEY HAVE WITH 581 00:22:04,960 --> 00:22:08,960 THEIR DATA SETS. IN THE BRAIN 582 00:22:08,960 --> 00:22:12,000 INITIATIVE ALSO MOVING FULL BORE 583 00:22:12,000 --> 00:22:14,160 FEBRUARY 22ND NIH LAUNCHED THE 584 00:22:14,160 --> 00:22:16,000 BRAIN INITIATIVE CONNECTIVITY 585 00:22:16,000 --> 00:22:17,760 ACROSS SCALES PROJECT. THIS IS A 586 00:22:17,760 --> 00:22:19,400 TRANSFORMATIVE PROJECT AIMED TO 587 00:22:19,400 --> 00:22:22,440 MAP NEUROCIRCUITS IN MICE HUMANS 588 00:22:22,440 --> 00:22:24,400 AND HUMAN PRIMATES WITH MULTIPLE 589 00:22:24,400 --> 00:22:24,960 FUNDING OPPORTUNITIES WITH 590 00:22:24,960 --> 00:22:28,080 RECEIPT DATES IN JULY. AND 591 00:22:28,080 --> 00:22:32,480 BEYOND. THE BRAIN INITIATIVE 592 00:22:32,480 --> 00:22:35,920 WILL HOST THEIR 8TH ANNUAL 593 00:22:35,920 --> 00:22:38,560 INVESTIGATOR MEETING ON JUNE 21 594 00:22:38,560 --> 00:22:40,840 AND 22, A VIRTUAL MEETING. 595 00:22:40,840 --> 00:22:42,320 ANYONE INTERESTED SHOULD GO 596 00:22:42,320 --> 00:22:43,800 AHEAD AND REGISTER FOR THAT 597 00:22:43,800 --> 00:22:45,080 MEETING, IT WILL BE EXCITING 598 00:22:45,080 --> 00:22:47,040 OPPORTUNITY TO SEE THE NEW 599 00:22:47,040 --> 00:22:48,440 DEVELOPMENTS THAT AROSE FROM THE 600 00:22:48,440 --> 00:22:49,480 BRAIN INITIATIVE PROGRAMS. NEXT 601 00:22:49,480 --> 00:22:55,960 SLIDE. NOW MOVING TO THE NIMH. 602 00:22:55,960 --> 00:22:57,360 THE NIMH NEWS I WILL TALK ABOUT 603 00:22:57,360 --> 00:22:59,160 BRIEFLY ABOUT A STRATEGIC PLAN. 604 00:22:59,160 --> 00:23:01,120 GIVE YOU AN UPDATE ON THE 605 00:23:01,120 --> 00:23:02,080 BALANCE OF THE NIMH PORTFOLIO 606 00:23:02,080 --> 00:23:03,560 WHICH I PROMISE TO DO 607 00:23:03,560 --> 00:23:06,800 PERIODICALLY. TALK ABOUT NIMH 608 00:23:06,800 --> 00:23:09,160 DIVERSITY EQUITY INCLUSION AND 609 00:23:09,160 --> 00:23:10,720 ACCESSIBILITY INITIATIVES. GIVE 610 00:23:10,720 --> 00:23:12,960 UPDATE ON THE INTERAGENCY AUTISM 611 00:23:12,960 --> 00:23:14,680 COORDINATING COMMITTEE, TALK 612 00:23:14,680 --> 00:23:17,320 ABOUT OUR PLANS FOR OUR 75TH 613 00:23:17,320 --> 00:23:19,360 ANNIVERSARY, IT WILL SOON BE 75 614 00:23:19,360 --> 00:23:21,760 YEARS SINCE FOUNDING OF NIMH AND 615 00:23:21,760 --> 00:23:28,120 COVER SOME STAFF NEWS. AS YOU 616 00:23:28,120 --> 00:23:30,560 ALL LIKELY KNOW, THE NIMH 617 00:23:30,560 --> 00:23:32,200 STRATEGIC PLAN HAS FOR THE LAST 618 00:23:32,200 --> 00:23:34,000 SEVERAL YEARS BEEN A LIVING 619 00:23:34,000 --> 00:23:35,680 BREATHING DOCUMENT ON THE WEB. 620 00:23:35,680 --> 00:23:38,800 AND WE DO FORMAL YEARLY UPDATES 621 00:23:38,800 --> 00:23:40,560 WHICH WE JUST COMPLETED AND 622 00:23:40,560 --> 00:23:44,960 WHICH ARE NOW ACCESSIBLE ON NIMH 623 00:23:44,960 --> 00:23:52,040 WEBSITE. THE UPDATES FOR 2022 624 00:23:52,040 --> 00:23:53,240 INCLUDE EXPANDED INFORMATION ON 625 00:23:53,240 --> 00:23:55,080 DEIA EFFORTS, LINKS TO NIMH 626 00:23:55,080 --> 00:23:58,000 APPROACH TO MENTAL HEALTH 627 00:23:58,000 --> 00:23:59,200 DISPARITIES RESEARCH CLIMATE 628 00:23:59,200 --> 00:24:01,360 CHANGE AND HEALTH INITIATIVE. 629 00:24:01,360 --> 00:24:02,440 REORGANIZE STRATEGIES TO MAP 630 00:24:02,440 --> 00:24:04,320 INTEREST AREAS ON TO THE 631 00:24:04,320 --> 00:24:06,040 PIPELINE OF NEURAL DEVELOPMENT, 632 00:24:06,040 --> 00:24:08,040 AND TWO NEW INTEREST AREAS THAT 633 00:24:08,040 --> 00:24:09,120 FOCUS ON ECONOMIC FACTORS OF 634 00:24:09,120 --> 00:24:14,120 RELEVANCE TO MENTAL HEALTH. THE 635 00:24:14,120 --> 00:24:16,720 STRATEGIC PLAN IS ACCOMPANIED BY 636 00:24:16,720 --> 00:24:20,320 A 2021 STRATEGIC PLAN PROGRESS 637 00:24:20,320 --> 00:24:23,080 REPORT THAT HAS SPOTLIGHTS 638 00:24:23,080 --> 00:24:26,440 ADVANCES MADE IN THE PAST YEAR. 639 00:24:26,440 --> 00:24:28,200 THAT HIGHLIGHT DIFFERENT AREAS 640 00:24:28,200 --> 00:24:30,600 OF THE GOALS OF THE PLAN AS WELL 641 00:24:30,600 --> 00:24:32,040 AS FAST FACTS FIGURES AT A 642 00:24:32,040 --> 00:24:35,920 GLANCE FOR 2021 INCLUDING FOR 643 00:24:35,920 --> 00:24:39,440 EXAMPLE SNAP SHOTS OF DIGITAL 644 00:24:39,440 --> 00:24:43,840 MEDIA, AND FOR EXAMPLE FUNDING 645 00:24:43,840 --> 00:24:51,600 OF NEXT GENERATION RESEARCHERS. 646 00:24:51,600 --> 00:24:52,960 I HAVE BEEN ATTEMPTING OVER THE 647 00:24:52,960 --> 00:24:54,480 YEARS TO BE AS TRANSPARENT AS 648 00:24:54,480 --> 00:24:56,800 POSSIBLE ABOUT THE BALANCE OF 649 00:24:56,800 --> 00:24:59,920 THE NIMH PORTFOLIO. IN 2017, MAY 650 00:24:59,920 --> 00:25:02,160 HAVE BEEN EARLY 2018 I WROTE MY 651 00:25:02,160 --> 00:25:03,320 FIRST MESSAGE ON THE BALANCE OF 652 00:25:03,320 --> 00:25:07,600 THE PORTFOLIO DESCRIBING TO IF 653 00:25:07,600 --> 00:25:09,200 COMMUNITY AT LARGE THE BALANCE 654 00:25:09,200 --> 00:25:12,520 OF INVESTMENTS THAT NIMH MAKE. 655 00:25:12,520 --> 00:25:13,800 AND I REPORTED OUT TO YOU I 656 00:25:13,800 --> 00:25:19,680 BELIEVE IN SEPTEMBER THE CURRENT 657 00:25:19,680 --> 00:25:23,240 BALANCE IN MARCH OF 2022 I 658 00:25:23,240 --> 00:25:24,040 PUBLISHED ANOTHER DIRECTOR 659 00:25:24,040 --> 00:25:25,040 MESSAGE UPDATING GENERAL 660 00:25:25,040 --> 00:25:25,920 COMMUNITY ON THAT PORTFOLIO 661 00:25:25,920 --> 00:25:27,640 BALANCE AND I WILL REITERATE 662 00:25:27,640 --> 00:25:34,120 THOSE DATA HERE AGAIN IF WE LOOK 663 00:25:34,120 --> 00:25:35,360 AT SHORT MEDIUM AND LONG-TERM 664 00:25:35,360 --> 00:25:37,280 INVESTMENT IN MENTAL HEALTH 665 00:25:37,280 --> 00:25:37,960 RETHESE ARE INVESTMENTS IN 666 00:25:37,960 --> 00:25:41,680 RESEARCH THAT HAVE THE POTENTIAL 667 00:25:41,680 --> 00:25:43,080 TO AFFECT HEALTHCARE DELIVERY IN 668 00:25:43,080 --> 00:25:45,520 SHORT MEDIUM AND/OR LONG TERM. 669 00:25:45,520 --> 00:25:48,560 ROUGHLY SPEAKING, APPROXIMATELY 670 00:25:48,560 --> 00:25:51,640 JUST LESS THAN 20% OF OUR 671 00:25:51,640 --> 00:25:53,720 RESEARCH FUNDS ARE EXPENDED ON 672 00:25:53,720 --> 00:25:56,720 FUNDAMENTAL BASIC RESEARCH. 673 00:25:56,720 --> 00:25:58,440 SOMETHING AROUND 35% DISEASE 674 00:25:58,440 --> 00:26:02,160 RELATED BAYING IS RESEARCH. 675 00:26:02,160 --> 00:26:03,920 SOMETHING AROUND 45, 50% 676 00:26:03,920 --> 00:26:05,120 THERAPEUTICS DEVELOPMENT AND 677 00:26:05,120 --> 00:26:07,520 SERVICES. THAT'S 2020 DATA YOU 678 00:26:07,520 --> 00:26:08,960 CAN SEE THE TRAJECTORIES OVER 679 00:26:08,960 --> 00:26:12,520 TIME, THERE'S BEEN SOME EXCHANGE 680 00:26:12,520 --> 00:26:15,320 OF EMPHASIS IN OUR PORTFOLIO 681 00:26:15,320 --> 00:26:17,800 INITIALLY IN 2010 THROUGH 2013 I 682 00:26:17,800 --> 00:26:22,200 EXPLAINED IN THE 2018 MESSAGE AS 683 00:26:22,200 --> 00:26:23,840 WELL AS AGAIN THE LAST SEVERAL 684 00:26:23,840 --> 00:26:26,360 YEARS SWITCH BACK TO FOCUS ON 685 00:26:26,360 --> 00:26:27,280 THERAPEUTICS DEVELOPMENT 686 00:26:27,280 --> 00:26:28,520 SERVICES. HAPPY TO TALK ABOUT 687 00:26:28,520 --> 00:26:30,720 REASONS WHY THIS MIGHT BE 688 00:26:30,720 --> 00:26:31,800 HAPPENING. ONE OF THOSE THINGS 689 00:26:31,800 --> 00:26:37,000 IS OUR EMPHASIS FROM 2016 TO 690 00:26:37,000 --> 00:26:38,880 2018 ON IMPORTANCE OF 691 00:26:38,880 --> 00:26:40,720 INTERVENTION RESEARCH AND 692 00:26:40,720 --> 00:26:42,360 PARTICULARLY IN THE PSYCHOSOCIAL 693 00:26:42,360 --> 00:26:44,880 REALM WHERE WE MADE SOME CHANGES 694 00:26:44,880 --> 00:26:45,960 TO OUR CLINICAL TRIALS 695 00:26:45,960 --> 00:26:47,400 ANNOUNCEMENTS TO MAKE IT CLEAR 696 00:26:47,400 --> 00:26:49,320 WHAT WE MEAN BY TARGETEDDED 697 00:26:49,320 --> 00:26:50,560 ENGAGEMENT IN THAT CONTEXT THAT 698 00:26:50,560 --> 00:26:52,760 LED TO INCREASE IN RESEARCH 699 00:26:52,760 --> 00:26:55,840 AREA. AS WELL AS RESURGENCE OF 700 00:26:55,840 --> 00:26:56,920 DIVISION OF SERVICES 701 00:26:56,920 --> 00:26:57,840 INTERVENTION RESEARCH 702 00:26:57,840 --> 00:26:59,840 PARTICULARLY WITH A FOCUS ON 703 00:26:59,840 --> 00:27:01,040 NOVEL IMPLEMENTATION STRATEGIES 704 00:27:01,040 --> 00:27:02,960 AND THE APPLICATIONS DING TALL 705 00:27:02,960 --> 00:27:05,160 TECHNOLOGIES. -- DIGITAL 706 00:27:05,160 --> 00:27:06,640 TECHNOLOGIES. YOU ALSO NOTICE 707 00:27:06,640 --> 00:27:09,560 OVER THE LAST SEVERAL YEARS A 708 00:27:09,560 --> 00:27:11,200 GRADUAL SHIFT IN BASIC RESEARCH 709 00:27:11,200 --> 00:27:12,720 PORTFOLIO FROM THE MEDIUM TERM 710 00:27:12,720 --> 00:27:15,080 DISEASE RELATED BASIC RESEARCH 711 00:27:15,080 --> 00:27:16,360 TO WHAT MIGHT BE SLIGHTLY LONGER 712 00:27:16,360 --> 00:27:19,000 TERM FUNDAMENTAL BASIC RESEARCH. 713 00:27:19,000 --> 00:27:20,720 I WANT TO POINT OUT THAT AMONG 714 00:27:20,720 --> 00:27:22,040 THE MANY REASONS WHY THAT MIGHT 715 00:27:22,040 --> 00:27:24,960 BE OCCURRING, WE HAVE ATTEMPTED 716 00:27:24,960 --> 00:27:27,200 OVER THE LAST SEVERAL YEARS TO 717 00:27:27,200 --> 00:27:29,560 INSIST THAT OUR ANIMAL 718 00:27:29,560 --> 00:27:30,640 RESEARCHERS AND RESEARCHERS 719 00:27:30,640 --> 00:27:33,320 USING OTHER MODELS SUCH AS HUMAN 720 00:27:33,320 --> 00:27:34,840 CELL MODELS APPROPRIATELY 721 00:27:34,840 --> 00:27:36,400 CHARACTERIZE THE HYPOTHESES THEY 722 00:27:36,400 --> 00:27:38,400 ARE TESTING AND NOT SIMPLY TRY 723 00:27:38,400 --> 00:27:41,520 TO SAY WE ARE MODELING 724 00:27:41,520 --> 00:27:46,320 SCHIZOPHRENIA IN AMEBA BUT ASK 725 00:27:46,320 --> 00:27:47,320 BASIC SCIENCE QUESTIONS WHEN 726 00:27:47,320 --> 00:27:48,320 APPROPRIATE AND ASK DISEASE 727 00:27:48,320 --> 00:27:49,360 RELATED QUESTIONS WHEN THEY ARE 728 00:27:49,360 --> 00:27:50,400 APPROPRIATE. AND WE THINK THIS 729 00:27:50,400 --> 00:27:51,880 ACCOUNTS FOR SOME OF THAT CHANGE 730 00:27:51,880 --> 00:27:53,480 THAT WE ARE SEEING OVER THE LAST 731 00:27:53,480 --> 00:27:58,360 SEVERAL YEARS. NEXT SLIDE. I'M 732 00:27:58,360 --> 00:27:59,800 OFTEN ASKED WHETHER THE BALANCE 733 00:27:59,800 --> 00:28:01,600 WE ARE STRIKING IS APPROPRIATE. 734 00:28:01,600 --> 00:28:03,920 I DON'T KNOW NECESSARILY HOW TO 735 00:28:03,920 --> 00:28:05,480 ANSWER THAT. I THINK EVERYONE 736 00:28:05,480 --> 00:28:07,200 HAS THEIR OWN INDIVIDUAL OPINION 737 00:28:07,200 --> 00:28:08,760 ABOUT HOW MUCH SHOULD BE SPENT 738 00:28:08,760 --> 00:28:10,640 ON SHORT MEDIUM OR LONG TERM 739 00:28:10,640 --> 00:28:11,920 RESEARCH AND INDEED MANY PEOPLE 740 00:28:11,920 --> 00:28:13,280 HAVE THEIR OWN OPINIONS ABOUT 741 00:28:13,280 --> 00:28:15,120 WHAT CONSTITUTES SHORT MEDIUM OR 742 00:28:15,120 --> 00:28:19,560 LONG TERM RESEARCH. HARD TO 743 00:28:19,560 --> 00:28:22,120 CATEGORIZE RESEARCH WE DO MUCH 744 00:28:22,120 --> 00:28:23,480 LESS OTHER INSTITUTES DO INTO 745 00:28:23,480 --> 00:28:24,880 THOSE FUNDAMENTAL BASIC DISEASE 746 00:28:24,880 --> 00:28:27,960 RELATED BASIC AND THERAPEUTICS 747 00:28:27,960 --> 00:28:35,080 DEVELOPMENT CANS. SO INSTEAD OF 748 00:28:35,080 --> 00:28:37,640 COMPARING THOSE WE CHOSE A 749 00:28:37,640 --> 00:28:38,520 CATEGORY ACROSS CLINICAL TRIALS 750 00:28:38,520 --> 00:28:41,120 RESEARCH WHICH HAS ITS OWN NIH 751 00:28:41,120 --> 00:28:43,240 WIDE SO CALLED RCDC CATEGORY 752 00:28:43,240 --> 00:28:46,280 WHICH IS AN NIH WIDE METHOD OF 753 00:28:46,280 --> 00:28:48,280 CATEGORIZING RESEARCH INTO 754 00:28:48,280 --> 00:28:51,280 SPECIFIC BUCKETS. IF YOU LOOK 755 00:28:51,280 --> 00:28:53,520 COMPARE THE NIMH AND NIH SUPPORT 756 00:28:53,520 --> 00:28:54,720 FOR CLINICAL TRIALS RESEARCH AS 757 00:28:54,720 --> 00:28:56,200 A PERCENT OF OUR TOTAL FUNDING, 758 00:28:56,200 --> 00:28:57,480 YOU CAN SEE THAT THEY MATCH 759 00:28:57,480 --> 00:29:01,960 QUITE NICELY. SO I DON'T KNOW IF 760 00:29:01,960 --> 00:29:04,440 IN 2020, 16% OF THE NIMH BUDGETS 761 00:29:04,440 --> 00:29:06,360 IS BEING SPENT OWN CLINICAL 762 00:29:06,360 --> 00:29:08,720 TRIALS RESEARCH IS THE RIGHT 763 00:29:08,720 --> 00:29:10,080 AMOUNT OF DOLLARS SPENT ON IT 764 00:29:10,080 --> 00:29:12,040 BUT WHAT I CAN SAY IS IT IS 765 00:29:12,040 --> 00:29:15,280 PRETTY MUCH WHAT THE NIH DOES AS 766 00:29:15,280 --> 00:29:17,520 A WHOLE. IF THAT IS A MARKER OF 767 00:29:17,520 --> 00:29:18,800 POTENTIAL SUCCESS I'M PLEASED 768 00:29:18,800 --> 00:29:27,000 WITH IT. OTHER NEWS BEYOND 769 00:29:27,000 --> 00:29:29,920 BUDGETARY BALANCE I WANT TO NOTE 770 00:29:29,920 --> 00:29:32,240 THAT WE CONTINUE WITH DEIA 771 00:29:32,240 --> 00:29:33,920 EFFORTS, ONE COMPONENT OF THAT 772 00:29:33,920 --> 00:29:35,520 ORGANIZED AT THE NIH LEVEL IS 773 00:29:35,520 --> 00:29:37,760 EACH INSTITUTE HAS TO FORMULATE 774 00:29:37,760 --> 00:29:42,160 RACIAL AND ETHNIC EQUITY PLAN OR 775 00:29:42,160 --> 00:29:44,840 REPLAN THE NIH REPLAN WAS 776 00:29:44,840 --> 00:29:47,560 FINALIZED IN MARCH, WAITING FROM 777 00:29:47,560 --> 00:29:48,800 FEEDBACK FROM NIH AND MAY MAKE 778 00:29:48,800 --> 00:29:50,560 ADJUSTMENTS ONCE WE RECEIVED 779 00:29:50,560 --> 00:29:53,240 THAT FEEDBACK. THREE MAIN GOALS 780 00:29:53,240 --> 00:29:55,320 OF THE REAP PLAN TO APPLY THE 781 00:29:55,320 --> 00:29:56,600 RACIAL EQUITY LENS FRAMEWORK TO 782 00:29:56,600 --> 00:29:59,520 THE IC WORK FORCE STRUCTURES 783 00:29:59,520 --> 00:30:01,200 SYSTEMS TO IDENTIFY DISMANTLE 784 00:30:01,200 --> 00:30:03,560 RACIAL AND ETHNIC DISPARITIES IN 785 00:30:03,560 --> 00:30:04,800 OUR WORK FORCE AND ENHANCE 786 00:30:04,800 --> 00:30:10,240 DIVERSITY OF OUR WORK FORCE. 787 00:30:10,240 --> 00:30:13,320 SUPPORTING THOSE GOALS FROM OUR 788 00:30:13,320 --> 00:30:15,600 PLAN WE HAVE IMPLEMENTED ALREADY 789 00:30:15,600 --> 00:30:18,320 SEVERAL MEASURES THAT ATTEMPT TO 790 00:30:18,320 --> 00:30:21,160 ADDRESS ISSUES OF ENVIRONMENT 791 00:30:21,160 --> 00:30:21,920 HERE AT NIMH AND ENHANCE 792 00:30:21,920 --> 00:30:24,120 DIVERSITY INCLUSIVENESS OF OUR 793 00:30:24,120 --> 00:30:27,200 WORKPLACE. WE INSTITUTED NIMH 794 00:30:27,200 --> 00:30:31,320 WIDE GROUND WATER TRAINING WITH 795 00:30:31,320 --> 00:30:33,000 CONTRACTING GROUND WATER TUT. 796 00:30:33,000 --> 00:30:35,320 THAT HELPS ALL NIMHERS 797 00:30:35,320 --> 00:30:37,120 UNDERSTAND THE ROLE OF SOCIAL 798 00:30:37,120 --> 00:30:39,200 DETERMINANTS AND HISTORY IN 799 00:30:39,200 --> 00:30:40,560 ESTABLISHING THE PLAYING FIELD 800 00:30:40,560 --> 00:30:43,040 WE ARE ALL IN RIGHT NOW. 801 00:30:43,040 --> 00:30:44,520 EMPHASIZING THE NEED TO ADDRESS 802 00:30:44,520 --> 00:30:45,520 THAT PLAYING FIELD THROUGH 803 00:30:45,520 --> 00:30:46,840 MEASURES THAT ENHANCE RACIAL 804 00:30:46,840 --> 00:30:51,680 EQUITY. NIMH LEADERSHIP TEAM 805 00:30:51,680 --> 00:30:53,800 AND SUPERVISORS PARTICIPATED IN 806 00:30:53,800 --> 00:30:54,920 THIS AND THE RECORDING IS 807 00:30:54,920 --> 00:30:56,040 AVAILABLE TO ALL STAFF TO ENSURE 808 00:30:56,040 --> 00:31:00,360 WE ALL KNOW WHERE WE ARE AT. 809 00:31:00,360 --> 00:31:03,120 NIMH IS ALSO LED STAFF TRAININGS 810 00:31:03,120 --> 00:31:05,360 ON MICROAGGRESSIONS IN CREATING 811 00:31:05,360 --> 00:31:07,480 A NEURODIVERSE INCLUSIVE 812 00:31:07,480 --> 00:31:08,520 WORKPLACE AS STRATEGIES TO 813 00:31:08,520 --> 00:31:13,400 INFORM CULTURE CHANGE HERE AT 814 00:31:13,400 --> 00:31:15,680 NIMH. WE ALSO CONTRACTED WITH 815 00:31:15,680 --> 00:31:17,560 THE ID PLANNING GROUP TO 816 00:31:17,560 --> 00:31:19,680 FACILITATE LISTENING SESSIONS 817 00:31:19,680 --> 00:31:22,200 WITH NIMH STAFF. THOSE 20 818 00:31:22,200 --> 00:31:24,560 SESSIONS WERE COMPLETED APRIL OF 819 00:31:24,560 --> 00:31:25,680 2022, WE AWAIT FINAL REPORT 820 00:31:25,680 --> 00:31:28,680 COMING ANY DAY NOW. SUMMARIZES 821 00:31:28,680 --> 00:31:31,280 THE COMMON THEMES THAT OUR STAFF 822 00:31:31,280 --> 00:31:32,760 RAISED. THIS REPORT FINDINGS 823 00:31:32,760 --> 00:31:36,000 SHARED WIDELY WITHIN NIMH AS 824 00:31:36,000 --> 00:31:38,120 WELL AS NIMH ANTI-RACIST TASK 825 00:31:38,120 --> 00:31:39,240 FORCE WHICH RECOMMENDED 826 00:31:39,240 --> 00:31:40,040 LISTENING SESSIONS IN THE FIRST 827 00:31:40,040 --> 00:31:41,480 PLACE TO INFORM RECOMMENDATIONS 828 00:31:41,480 --> 00:31:43,960 TO NIMH LEADERSHIP THAT WILL 829 00:31:43,960 --> 00:31:44,480 ADDITIONALLY IMPROVE OUR 830 00:31:44,480 --> 00:31:50,520 ENVIRONMENT. THAT IS A SUMMARY 831 00:31:50,520 --> 00:31:52,600 OF SOME OF THE ACTIVITIES WE 832 00:31:52,600 --> 00:31:54,120 ENGAGED IN AROUND DIVERSITY 833 00:31:54,120 --> 00:31:56,160 EQUITY INCLUSION AND 834 00:31:56,160 --> 00:31:58,040 ACCESSIBILITY. NOW I WILL TURN 835 00:31:58,040 --> 00:31:58,960 TO ANOTHER RESPONSE NIMH TO 836 00:31:58,960 --> 00:32:00,920 OVERSEE THE INTERAGENCY AUTISM 837 00:32:00,920 --> 00:32:04,280 COORDINATING COMMITTEE. UNDER 838 00:32:04,280 --> 00:32:06,920 THE THE AUSPICES OF DR. SUSAN 839 00:32:06,920 --> 00:32:09,040 DANIELS THE IACC EXPECT 840 00:32:09,040 --> 00:32:10,680 SECRETARY AND DIRECTOR OF AUTISM 841 00:32:10,680 --> 00:32:12,520 RESEARCH COORDINATION. ON APRIL 842 00:32:12,520 --> 00:32:15,200 13 AND 14 THE IACC HELD THE 843 00:32:15,200 --> 00:32:17,640 THIRD MEETING FROM THIS 844 00:32:17,640 --> 00:32:20,320 INCARNATION OF IACC WHICH WAS A 845 00:32:20,320 --> 00:32:21,760 VIRTUAL MEETING, DISCUSSED 846 00:32:21,760 --> 00:32:22,800 HOUSING AND COMMUNICATIONS 847 00:32:22,800 --> 00:32:26,040 RESEARCH. THE IACC CONTINUES TO 848 00:32:26,040 --> 00:32:27,920 DEVELOP 2021, 2022 STRATEGIC 849 00:32:27,920 --> 00:32:28,840 PLAN FOR AUTISM RESEARCH 850 00:32:28,840 --> 00:32:32,480 SERVICES AND POLICY AND IN JUNE, 851 00:32:32,480 --> 00:32:34,800 THIS MONTH THE IACC HAS OR WILL 852 00:32:34,800 --> 00:32:36,840 NOT SURE IF IT CAME OUT TODAY OR 853 00:32:36,840 --> 00:32:39,520 NOT, PUBLISH THE 2020 SUMMARY OF 854 00:32:39,520 --> 00:32:41,480 ADVANCES IN AUTISM SPECTRUM 855 00:32:41,480 --> 00:32:43,080 DISORDER THAT IS AN ACCOUNTING 856 00:32:43,080 --> 00:32:53,360 OF MAJOR ADVANCES 857 00:34:54,320 --> 00:34:56,160 IN THAT WAY HE WILL CONTINUE A 858 00:34:56,160 --> 00:34:59,000 ROLE AT NIMH THAT HE HAS DONE 859 00:34:59,000 --> 00:35:03,560 WITH OUTSTANDING RESULTS. 860 00:35:03,560 --> 00:35:05,640 TRYING TO ENSURE RESEARCH 861 00:35:05,640 --> 00:35:06,200 FINDINGS INSTITUTE DEVELOPS 862 00:35:06,200 --> 00:35:12,960 INFLUENCE POLICY AT THE FEDERAL 863 00:35:12,960 --> 00:35:19,360 LEVEL HAS AGREED TO SERVE AS 864 00:35:19,360 --> 00:35:20,960 INTERIM ACTING DIRECTOR 865 00:35:20,960 --> 00:35:24,200 EFFECTIVE JULY 3RD. I KNOW IT'S 866 00:35:24,200 --> 00:35:25,680 REALLY HARD TO DO VIRTUALLY BUT 867 00:35:25,680 --> 00:35:28,680 I ALSO KNOW MANY OF YOU HAVE 868 00:35:28,680 --> 00:35:29,880 KNOWN AND RECOGNIZED BOB'S 869 00:35:29,880 --> 00:35:31,240 EXCELLENCE OVER THE YEARS, SO 870 00:35:31,240 --> 00:35:32,480 I'M GOING TO ASK FOR A ROUND OF 871 00:35:32,480 --> 00:35:35,200 APPLAUSE. AND FOR HIS SERVICE 872 00:35:35,200 --> 00:35:36,880 OVER MANY, MANY YEARS TO NIMH AS 873 00:35:36,880 --> 00:35:47,200 DIRECTOR. I KNOW YOU CAN'T 874 00:35:47,200 --> 00:35:49,160 REALLY HEAR THE STUFF OVER ZOOM 875 00:35:49,160 --> 00:35:51,320 BUT I KNOW YOU ARE LISTENING AND 876 00:35:51,320 --> 00:35:52,920 YOU APPRECIATE HOW MANY PEEP IN 877 00:35:52,920 --> 00:35:53,840 THIS ROOM THINK SO HIGHLY OF 878 00:35:53,840 --> 00:35:55,440 YOUR EFFORTS. YOU WILL BE MISS 879 00:35:55,440 --> 00:35:56,640 IN THE ROLE YOU ARE LEAVING AND 880 00:35:56,640 --> 00:35:58,120 GREATLY VALUED IN THE ROLE THAT 881 00:35:58,120 --> 00:36:06,920 YOU ARE ABOUT TO ASSUME. 882 00:36:06,920 --> 00:36:08,200 IN ADDITION IN ADDITION TO 883 00:36:08,200 --> 00:36:10,080 RECRUITING NEW DIRECTOR OF 884 00:36:10,080 --> 00:36:11,200 SERVICES INTERVENTION RESEARCH 885 00:36:11,200 --> 00:36:12,600 WE ARE ALSO RECRUITING FOR A 886 00:36:12,600 --> 00:36:14,800 DEPUTY DIRECTOR OF OFFICE OF 887 00:36:14,800 --> 00:36:15,960 CLINICAL RESEARCH, RECRUITMENTS 888 00:36:15,960 --> 00:36:17,200 TO COME THAT I CAN'T ANNOUNCE 889 00:36:17,200 --> 00:36:18,480 YET BUT HOPEFULLY ANNOUNCED SOON 890 00:36:18,480 --> 00:36:19,760 SO PAY ATTENTION TO THOSE OF YOU 891 00:36:19,760 --> 00:36:21,840 INTERESTED IN JOINING. REALLY A 892 00:36:21,840 --> 00:36:26,440 WONDERFUL PLACE TO WORK AND HAVE 893 00:36:26,440 --> 00:36:27,680 MAXIMUM IMPACT ON MENTAL HEALTH 894 00:36:27,680 --> 00:36:28,920 RESEARCH THROUGHOUT THE COUNTRY 895 00:36:28,920 --> 00:36:31,040 AND AROUND THE WORLD. SO PLEASE 896 00:36:31,040 --> 00:36:33,280 LOOK FOR THESE JOB OPPORTUNITIES 897 00:36:33,280 --> 00:36:36,320 NIMH CAREERS WEBSITE IN THE USA 898 00:36:36,320 --> 00:36:40,600 JOBS. NEXT SLIDE. IN OTHER 899 00:36:40,600 --> 00:36:45,400 NEWS, DR. JOYCE CHUNG, DEPUTY 900 00:36:45,400 --> 00:36:47,160 CLINICAL DIRECTOR OF NIMH 901 00:36:47,160 --> 00:36:49,040 CLINICAL RESEARCH PROGRAM AND 902 00:36:49,040 --> 00:36:49,920 DIRECTOR OF TRAINING 903 00:36:49,920 --> 00:36:51,600 OPPORTUNITIES IS SERVING AS THE 904 00:36:51,600 --> 00:36:53,720 NIH CLINICAL CENTER DESIGNATED 905 00:36:53,720 --> 00:36:54,920 INSTITUTIONAL OFFICER AND 906 00:36:54,920 --> 00:36:56,640 EXECUTIVE DIRECTOR OF GRADUATE 907 00:36:56,640 --> 00:36:57,920 MEDICAL EDUCATION OVERSEEING 908 00:36:57,920 --> 00:37:00,960 MANY OF THE GME ACREDITSED 909 00:37:00,960 --> 00:37:03,000 RESIDENCY AND FELLOWSHIP 910 00:37:03,000 --> 00:37:06,280 PROGRAMS THAT NIH OFFERS. REALLY 911 00:37:06,280 --> 00:37:08,040 WONDERFUL OPPORTUNITIES FOR 912 00:37:08,040 --> 00:37:09,520 JOYCE AND SHE WILL BE MISSED AT 913 00:37:09,520 --> 00:37:11,320 NIH WE ARE GLAD SHE WILL 914 00:37:11,320 --> 00:37:12,320 CONTINUE TO SERVE THE MISSION OF 915 00:37:12,320 --> 00:37:16,320 THE CLINICAL CENTER AROUND 916 00:37:16,320 --> 00:37:20,880 EDUCATION. OTHER HAPPY NEWS IN 917 00:37:20,880 --> 00:37:23,000 THE INTRAMURAL RESEARCH PROGRAM, 918 00:37:23,000 --> 00:37:27,720 DR. SUSAN AMARA DIRECTOR OF IRP 919 00:37:27,720 --> 00:37:31,320 AND MARILYN POWELL CLINICAL 920 00:37:31,320 --> 00:37:32,240 DEPUTY DIRECTOR HAVE BEEN HARD 921 00:37:32,240 --> 00:37:34,640 AT WORK. THE TWO NEW MEMBERS ARE 922 00:37:34,640 --> 00:37:38,680 JAMES BOURNE AND ANGELA LANGDON. 923 00:37:38,680 --> 00:37:40,160 THEY COME TO THE IRP AS 924 00:37:40,160 --> 00:37:42,480 INVESTIGATORS CHIEF OF SECTIONS 925 00:37:42,480 --> 00:37:45,520 AND UNITS. DR. BOURNE COME AS 926 00:37:45,520 --> 00:37:49,320 SENIOR INVESTIGATOR, DR. LANGDON 927 00:37:49,320 --> 00:37:50,720 AS TENURE TRACK INVESTIGATOR. WE 928 00:37:50,720 --> 00:37:52,000 ARE EXCITED ABOUT THE 929 00:37:52,000 --> 00:37:53,880 CONTRIBUTIONS TO MAKE TO OUR 930 00:37:53,880 --> 00:37:56,760 YOUR COMMUNITY AND THE RESEARCH 931 00:37:56,760 --> 00:38:00,960 COMMUNITY AT LARGE. FINALLY DR. 932 00:38:00,960 --> 00:38:02,400 HOLLY LISANBY DIVISION OF 933 00:38:02,400 --> 00:38:04,760 TRANSLATION RESEARCH IS 934 00:38:04,760 --> 00:38:05,520 EVENTUALLY UNDUCTED AS A 935 00:38:05,520 --> 00:38:06,680 DISTINGUISHED LIFE FELLOW OF THE 936 00:38:06,680 --> 00:38:07,960 AMERICAN PSYCHIATRIC 937 00:38:07,960 --> 00:38:08,920 ASSOCIATION, CONGRATULATIONS, 938 00:38:08,920 --> 00:38:13,080 HOLLY. NEXT SLIDE. AND OUR OWN 939 00:38:13,080 --> 00:38:15,840 DR. VICTORIA ARANGO WHO IS A 940 00:38:15,840 --> 00:38:18,080 PROGRAM OFFICER IN DIVISION OF 941 00:38:18,080 --> 00:38:19,520 TRANSLATIONAL RESEARCH WHO WAS 942 00:38:19,520 --> 00:38:21,320 RECENTLY ELECTED PRESIDENT 943 00:38:21,320 --> 00:38:22,480 SOCIETY OF BIOLOGICAL 944 00:38:22,480 --> 00:38:24,280 PSYCHIATRY. THOSE FOLLOWING THE 945 00:38:24,280 --> 00:38:26,160 ANNOUNCEMENTS KNOW THAT MANY 946 00:38:26,160 --> 00:38:29,880 NIMHS THAT SERVE IN LEADERSHIP 947 00:38:29,880 --> 00:38:32,440 ROLES THE AMERICAN COLLEGE OF 948 00:38:32,440 --> 00:38:32,960 NEUROPSYCHOPHARMACOLOGY 949 00:38:32,960 --> 00:38:36,200 SOLIDIFYING IMPACT ON BIOLOGICAL 950 00:38:36,200 --> 00:38:38,640 PSYCHIATRY AT LARGE. 951 00:38:38,640 --> 00:38:40,040 FINALLY, I WILL TAKE THE LAST 952 00:38:40,040 --> 00:38:43,560 FEW MINUTES TO TALK ABOUT 953 00:38:43,560 --> 00:38:45,200 SCIENCE HIGHLIGHTS. 954 00:38:45,200 --> 00:38:48,080 THOSE OF YOU FOLLOWING 955 00:38:48,080 --> 00:38:51,760 PSYCHIATRIC GENETICS, ARE MOST 956 00:38:51,760 --> 00:38:53,200 LIKELY LIKE ME, QUITE PLEASE 957 00:38:53,200 --> 00:38:54,320 WITH THE PROGRESS THAT WE HAVE 958 00:38:54,320 --> 00:38:55,720 BEEN MAKING OVER THE YEARS IN 959 00:38:55,720 --> 00:38:56,960 TERMS OF IDENTIFYING THE NUMBER 960 00:38:56,960 --> 00:38:58,960 OF DIFFERENT GENES, PLACES IN 961 00:38:58,960 --> 00:39:00,760 THE GENOME, THAT LEAD TO 962 00:39:00,760 --> 00:39:01,800 SCHIZOPHRENIA BUT ALSO 963 00:39:01,800 --> 00:39:03,920 FRUSTRATED AND BEWILDERED BY THE 964 00:39:03,920 --> 00:39:06,400 SHEER NUMBER. AND AT TIMES 965 00:39:06,400 --> 00:39:08,520 DISPAIRING FOR CLINICAL -- 966 00:39:08,520 --> 00:39:11,040 CHANGING THE LINKAGES INTO 967 00:39:11,040 --> 00:39:13,480 BIOLOGIC KNOWLEDGE ABOUT OUR SEW 968 00:39:13,480 --> 00:39:16,960 I WANT TO UPDATE YOU TWO 969 00:39:16,960 --> 00:39:19,040 SIMULTANEOUSLY PUBLISHED PAPERS 970 00:39:19,040 --> 00:39:20,680 THAT MOVE US FORWARD FROM SIMPLY 971 00:39:20,680 --> 00:39:23,520 LISTS OF GENES TO BIOLOGICAL 972 00:39:23,520 --> 00:39:26,360 PATHWAYS. BOTH OF THEM ARE 973 00:39:26,360 --> 00:39:28,240 RESULT OF NIMH AND OTHER FUNDING 974 00:39:28,240 --> 00:39:30,360 AGENCIES THAT HAVE SUPPORTED 975 00:39:30,360 --> 00:39:34,760 THIS KIND OF RESEARCH. THE FIRST 976 00:39:34,760 --> 00:39:36,600 PAPER LOOKS AT COMMON GENE 977 00:39:36,600 --> 00:39:38,880 VARIANTS AND TRIES TO UNDERSTAND 978 00:39:38,880 --> 00:39:41,680 WHETHER WE CAN GET TO BIOLOGY 979 00:39:41,680 --> 00:39:45,320 THROUGH THEM IN THE AREA OF 980 00:39:45,320 --> 00:39:49,280 SCHIZOPHRENIA. SO IN THIS LATEST 981 00:39:49,280 --> 00:39:51,280 UPDATE, THE NUMBER OF PLACES IN 982 00:39:51,280 --> 00:39:53,680 THE GENOME THAT HAVE NOW BEEN 983 00:39:53,680 --> 00:39:55,200 STATISTICALLY SIGNIFICANTLY LEAD 984 00:39:55,200 --> 00:39:56,920 TO SCHIZOPHRENIA HAS INCREASED 985 00:39:56,920 --> 00:39:59,040 YET AGAIN TO WELL OVER 250 986 00:39:59,040 --> 00:40:00,600 PLACES IN THE GENOME. EACH ONE 987 00:40:00,600 --> 00:40:03,560 OF THEM HERE REPRESENTED BY 988 00:40:03,560 --> 00:40:08,160 THOSE GREEN TRIANGLES SCATTERED 989 00:40:08,160 --> 00:40:11,000 THROUGHOUT THE GENOME. AND THIS 990 00:40:11,000 --> 00:40:12,480 REPRESENTS THE MAIN 991 00:40:12,480 --> 00:40:18,760 ACCOMPLISHMENT OF GENOME WIDE 992 00:40:18,760 --> 00:40:20,960 ASSOCIATION 993 00:40:20,960 --> 00:40:24,160 STUDIES. 994 00:40:24,160 --> 00:40:25,480 GWAS STUDIES HAVE IDENTIFIED 995 00:40:25,480 --> 00:40:27,760 MANY, MANY PLACES AND ALSO THEN 996 00:40:27,760 --> 00:40:30,280 HOW WE TAKE THESE PLACES IN THE 997 00:40:30,280 --> 00:40:32,720 GENOME AND TRANSFER THEM INTO 998 00:40:32,720 --> 00:40:34,840 BIOLOGY. SYSTEMS BIOLOGY HAS 999 00:40:34,840 --> 00:40:38,280 COME TO THE RESCUE. ONE CAN 1000 00:40:38,280 --> 00:40:40,440 USING A RANGE OF DIFFERENT 1001 00:40:40,440 --> 00:40:42,160 TECHNIQUES, TRY TO IDENTIFY FOR 1002 00:40:42,160 --> 00:40:44,560 THOSE PLACES IN THE GENOME THE 1003 00:40:44,560 --> 00:40:48,800 MOST LIKELY GENES THAT ARE 1004 00:40:48,800 --> 00:40:51,040 RESPONSIBLE FOR THE LINKAGE TO 1005 00:40:51,040 --> 00:40:53,520 SCHIZOPHRENIA. AND THEN ASK WHAT 1006 00:40:53,520 --> 00:40:56,480 KIND OF GENES THOSE ARE. AND 1007 00:40:56,480 --> 00:40:59,880 WHEN ONE DOES THAT, USING THE 1008 00:40:59,880 --> 00:41:01,560 APPROPRIATE STATISTICAL 1009 00:41:01,560 --> 00:41:03,000 TECHNIQUINGS, YOU CAN GET A 1010 00:41:03,000 --> 00:41:05,120 SENSE OF WHAT BIOLOGICAL 1011 00:41:05,120 --> 00:41:07,520 PATHWAYS AND/OR ANATOMICAL 1012 00:41:07,520 --> 00:41:09,520 LOCALIZATIONS ARE 1013 00:41:09,520 --> 00:41:12,960 OVERREPRESENTED IN THE GENE CELL 1014 00:41:12,960 --> 00:41:13,760 THAT IS LIKELY RESPONSIBLE FOR 1015 00:41:13,760 --> 00:41:15,160 COMMON VARIANT RISK ASSOCIATED 1016 00:41:15,160 --> 00:41:18,400 WITH SCHIZOPHRENIA. WHEN YOU DO 1017 00:41:18,400 --> 00:41:22,160 THAT, ONE ANSWER COMES OUT AS 1018 00:41:22,160 --> 00:41:23,400 PARTICULARLY STATISTICALLY 1019 00:41:23,400 --> 00:41:26,320 ROBUST. THAT IS A VERY LARGE 1020 00:41:26,320 --> 00:41:32,080 NUMBER OF THESE LIKELY GENES ARE 1021 00:41:32,080 --> 00:41:33,480 ASSOCIATED WITH THE SYNAPSE. IN 1022 00:41:33,480 --> 00:41:35,160 PARTICULAR THAT INCLUDES SIZE OF 1023 00:41:35,160 --> 00:41:37,680 THE SYNAPSE, PRE-SYNAPSE AND 1024 00:41:37,680 --> 00:41:38,520 POST SYNAPSE AND MULTIPLE 1025 00:41:38,520 --> 00:41:40,960 DIFFERENT COMPONENTS OF THOSE 1026 00:41:40,960 --> 00:41:43,800 SYNAPTIC LOCATIONS, WHETHER IT 1027 00:41:43,800 --> 00:41:46,400 BE POST SYNAPTIC DENSITY OR POST 1028 00:41:46,400 --> 00:41:47,640 SYNAPTIC MEMBRANE, ACTIVE ZONE 1029 00:41:47,640 --> 00:41:49,400 ON THE PRE-SYNAPTIC SIDE, 1030 00:41:49,400 --> 00:41:52,720 SYNAPTIC VESICALES, PRE-SYNAPTIC 1031 00:41:52,720 --> 00:41:54,600 MEMBRANE OR ZONE WHERE SYNAPTIC 1032 00:41:54,600 --> 00:41:56,360 VESICALES ARE DOCKED WITH THE 1033 00:41:56,360 --> 00:41:58,440 MEMBRANE. EACH OF THOSE PLACES 1034 00:41:58,440 --> 00:42:00,960 IS REPRESENTED OR I SHOULD SAY 1035 00:42:00,960 --> 00:42:02,240 OVERREPRESENTED EACH OF THE 1036 00:42:02,240 --> 00:42:03,360 MOLECULAR COMPONENTS OF THOSE 1037 00:42:03,360 --> 00:42:05,080 PLACES ARE OVERREPRESENTED ON 1038 00:42:05,080 --> 00:42:07,360 THE RISK -- LIST OF RISK GENES 1039 00:42:07,360 --> 00:42:09,280 FOR SCHIZOPHRENIA. SUGGESTING 1040 00:42:09,280 --> 00:42:10,560 INDEED THAT WE SHOULD BE PAYING 1041 00:42:10,560 --> 00:42:12,320 ATTENTION TO TO SYNAPTIC BIOLOGY 1042 00:42:12,320 --> 00:42:13,520 IF WE WANT TO UNDERSTAND GENETIC 1043 00:42:13,520 --> 00:42:19,320 RISK FOR SCHIZOPHRENIA. THIS 1044 00:42:19,320 --> 00:42:21,280 NEXT PAPER PUBLISHED 1045 00:42:21,280 --> 00:42:23,200 SIMULTANEOUSLY IN NATURE LOOKED 1046 00:42:23,200 --> 00:42:25,480 INSTEAD OF RARE -- THE COMMON 1047 00:42:25,480 --> 00:42:26,760 VARIANTS THAT ACCOUNT FOR EACH 1048 00:42:26,760 --> 00:42:28,960 SMALL AMOUNTS OF RISK LOOK FOR 1049 00:42:28,960 --> 00:42:30,760 OPPORTUNITIES TO IDENTIFY RARE 1050 00:42:30,760 --> 00:42:32,600 CODING VARIANTS THAT ENCODE 1051 00:42:32,600 --> 00:42:34,400 LARGE AMOUNTS OF RISK FOR 1052 00:42:34,400 --> 00:42:37,920 SCHIZOPHRENIA. IN THIS PAPER 1053 00:42:37,920 --> 00:42:41,480 IDENTIFIED APPROXIMATELY 10 1054 00:42:41,480 --> 00:42:45,280 GENES WHICH MEET A VERY, VERY 1055 00:42:45,280 --> 00:42:47,520 STRINGENT STATISTICAL CRITERIA 1056 00:42:47,520 --> 00:42:49,200 FOR BEING LINKED TO 1057 00:42:49,200 --> 00:42:50,320 SCHIZOPHRENIA, THEY ARE LISTED 1058 00:42:50,320 --> 00:42:51,280 HERE, AS WELL AS SOMETHING ON 1059 00:42:51,280 --> 00:42:54,360 THE ORDER OF ANOTHER 20 GENES OR 1060 00:42:54,360 --> 00:42:58,400 SO, HERE IN YELLOW. WHICH ARE 1061 00:42:58,400 --> 00:43:00,320 LIKELY ASSOCIATED WITH 1062 00:43:00,320 --> 00:43:02,200 SCHIZOPHRENIA BUT DON'T MEET THE 1063 00:43:02,200 --> 00:43:03,240 SAME STRINGENT STATISTICAL 1064 00:43:03,240 --> 00:43:06,560 CRITERIA WITH THE CURRENT DATA 1065 00:43:06,560 --> 00:43:08,360 SET. I WILL POINT OUT, IF YOU 1066 00:43:08,360 --> 00:43:11,120 CAN ADVANCE ONE MORE, GO BACK, 1067 00:43:11,120 --> 00:43:12,280 SORRY, THOUGHT THERE WAS A 1068 00:43:12,280 --> 00:43:15,240 CIRCLE, POINT OUT SEVERAL OF 1069 00:43:15,240 --> 00:43:18,440 THESE SUCH AS GRIN 2A, CACNAC 1070 00:43:18,440 --> 00:43:21,200 AND GIA 13 REPRESENT GENES 1071 00:43:21,200 --> 00:43:23,760 EXPRESSED IN SYNAPSES. AND SO IN 1072 00:43:23,760 --> 00:43:26,160 THE CASE OF RARE VARIATION THAT 1073 00:43:26,160 --> 00:43:28,800 CONFERS LARGE AMOUNTS OF RISK, 1074 00:43:28,800 --> 00:43:30,640 SOME OF THESE HARD TO ESTIMATE 1075 00:43:30,640 --> 00:43:32,400 RISK BECAUSE THEY ARE SO RARE 1076 00:43:32,400 --> 00:43:36,400 BUT FOR EXAMPLE GRIN 2A, THESE 1077 00:43:36,400 --> 00:43:38,440 ARE MANY TENS OF MULTIPLES OF 1078 00:43:38,440 --> 00:43:42,640 RISK HIGHER, HIGHER RISK OF 1079 00:43:42,640 --> 00:43:44,640 GETTING SCHIZOPHRENIA IF YOU 1080 00:43:44,640 --> 00:43:46,720 HAVE THE GENE VARIANT IN THE 1081 00:43:46,720 --> 00:43:48,680 GENES THAT STOPS THE FUNCTION OF 1082 00:43:48,680 --> 00:43:51,280 THE GENE. ANY CASE, BPO STIPES 1083 00:43:51,280 --> 00:43:53,320 OF GENETIC RISK SYNAPSE BIOLOGY 1084 00:43:53,320 --> 00:43:54,360 IS COMING UP AS SOMETHING THAT 1085 00:43:54,360 --> 00:43:56,880 WE NEED TO PAY ATTENTION TO IF 1086 00:43:56,880 --> 00:43:59,920 YOU WANT TO UNDERSTAND 1087 00:43:59,920 --> 00:44:04,080 SCHIZOPHRENIA. SO MOVING AWAY 1088 00:44:04,080 --> 00:44:06,880 FROM GENETIC DISCOVERY, UP THE 1089 00:44:06,880 --> 00:44:07,920 TRANSLATIONAL PIPELINE, I WANT 1090 00:44:07,920 --> 00:44:09,600 TO TELL YOU ABOUT ANOTHER PAPER 1091 00:44:09,600 --> 00:44:11,600 THAT'S BEEN PUBLISHED EARLY THIS 1092 00:44:11,600 --> 00:44:16,200 YEAR, LOOKING AT TRYING TO 1093 00:44:16,200 --> 00:44:19,080 UNDERSTAND THE BIOLOGY OF 1094 00:44:19,080 --> 00:44:22,640 ANXIETY. AND IN PARTICULAR ITS 1095 00:44:22,640 --> 00:44:24,200 INTERSECTION WITH AUTONOMIC 1096 00:44:24,200 --> 00:44:26,200 NERVOUS SYSTEM. SO ONE OF THE 1097 00:44:26,200 --> 00:44:28,960 THEORIES OF ANXIETY IS WE HAVE 1098 00:44:28,960 --> 00:44:31,720 AN OVERACTIVE RESPONSE TO 1099 00:44:31,720 --> 00:44:36,680 AUTONOMIC STIMULI. AND SO CALLED 1100 00:44:36,680 --> 00:44:39,440 AUTONOMIC HYPERSENSITIVITY. 1101 00:44:39,440 --> 00:44:41,600 REGULATING AUTONOMIC SENSITIVITY 1102 00:44:41,600 --> 00:44:48,960 IS THE JOB WE THINK OF THE 1103 00:44:48,960 --> 00:44:50,600 VENTROMEDIAL PREFRONTAL CORTEX, 1104 00:44:50,600 --> 00:44:53,960 VARIOUS METHODS ARE USED TO SHOW 1105 00:44:53,960 --> 00:44:55,880 AUTONOMIC, ONE TO USE ADRENERGIC 1106 00:44:55,880 --> 00:44:58,720 STIMULATION AS A PROBE, YOU CAN 1107 00:44:58,720 --> 00:44:59,920 SHOW INDIVIDUALS WITH GENERALIZE 1108 00:44:59,920 --> 00:45:02,640 ANXIETY DISORDER ARE MORE 1109 00:45:02,640 --> 00:45:04,800 SENSITIVE TO MORE PERIPHERAL 1110 00:45:04,800 --> 00:45:05,920 ADRENERGIC STIMULATION. THIS 1111 00:45:05,920 --> 00:45:08,080 PAPER ATTEMPTED TO UNDERSTAND 1112 00:45:08,080 --> 00:45:09,000 WHETHER THERE'S DIFFERENCES IN 1113 00:45:09,000 --> 00:45:10,560 THE BRAINS OF GAD THAT ACCOUNT 1114 00:45:10,560 --> 00:45:14,360 FOR THEIR AUTONOMIC 1115 00:45:14,360 --> 00:45:17,960 HYPERSENSITIVISENSITIVITY. THISH 1116 00:45:17,960 --> 00:45:19,240 SHOWED THAT PATIENTS WITH 1117 00:45:19,240 --> 00:45:24,520 GENERALIZED ANXIETY DISORDER 1118 00:45:24,520 --> 00:45:26,880 HAVE DEFICITS IN THEIR VENTRO 1119 00:45:26,880 --> 00:45:28,520 MEDIAL PREFRONTAL CORTEX 1120 00:45:28,520 --> 00:45:30,480 RESPONSE TO STIMULATION WITH 1121 00:45:30,480 --> 00:45:32,360 ADRENERGIC ACTIVITY, THEY HAVE A 1122 00:45:32,360 --> 00:45:36,320 BLUNTED RESPONSE TO THE 1123 00:45:36,320 --> 00:45:37,360 ADRENERGIC STIMULATION 1124 00:45:37,360 --> 00:45:40,840 SUGGESTING PERHAPS THAT THE 1125 00:45:40,840 --> 00:45:41,600 VMPFC IS UNABLE TO ACCOMPLISH 1126 00:45:41,600 --> 00:45:46,960 ITS ROLE. AND THEY ALSO HAVE 1127 00:45:46,960 --> 00:45:50,160 DIFFERENCES IN MANY THE VENTRO 1128 00:45:50,160 --> 00:45:54,240 MEDIAL PREFRONTAL CORTEX IN THE 1129 00:45:54,240 --> 00:45:57,560 INSULA AS WELL, SORRY DIFFERENT 1130 00:45:57,560 --> 00:45:59,840 PART OF THE CORTEX, WHERE THE 1131 00:45:59,840 --> 00:46:02,920 PATIENT WITH GAD HAVE AN 1132 00:46:02,920 --> 00:46:06,160 INCREASE IN THE ACTIVITY WITHIN 1133 00:46:06,160 --> 00:46:16,760 THE INSULA. WHAT DOES THAT MEAN 1134 00:46:16,760 --> 00:46:20,200 IT MAY BE A WAY TO IDENTIFY 1135 00:46:20,200 --> 00:46:22,320 INDIVIDUALS WITH GAD WHO HAVE A 1136 00:46:22,320 --> 00:46:24,800 PARTICULAR TYPE OF GAD, 1137 00:46:24,800 --> 00:46:27,440 AUTONOMIC HYPERSENSITIVITY. AND 1138 00:46:27,440 --> 00:46:29,280 TARGET TREATMENTS THAT MIGHT 1139 00:46:29,280 --> 00:46:30,360 UPREGULATE ACTIVITY IN THESE 1140 00:46:30,360 --> 00:46:32,360 BRAIN REGIONS THAT ARE 1141 00:46:32,360 --> 00:46:33,640 INAPPROPRIATELY DOWN REGULATED 1142 00:46:33,640 --> 00:46:36,480 OR VICE VERSA, IN ORDER TO 1143 00:46:36,480 --> 00:46:41,320 ATTEMPT TO REDUCE ANXIETY. 1144 00:46:41,320 --> 00:46:41,920 IMPORTANTLY WHETHER OR NOT THAT 1145 00:46:41,920 --> 00:46:43,200 WORKS AS TREATMENT IT CAN WORK 1146 00:46:43,200 --> 00:46:44,320 AS WAY TO TEST THE THEORY 1147 00:46:44,320 --> 00:46:46,280 ITSELF. REMEMBER THE THEORY IS 1148 00:46:46,280 --> 00:46:48,360 THAT AUTONOMIC HYPERSENSITIVITY, 1149 00:46:48,360 --> 00:46:52,360 HYPERSENSITIVITY TO YOUR OWN 1150 00:46:52,360 --> 00:46:54,760 BODILY SIGNAL COULD IN AND OF 1151 00:46:54,760 --> 00:46:56,320 ITSELF CAUSE ANXIETY SYMPTOMS 1152 00:46:56,320 --> 00:46:57,680 AND WE CAN NOW TEST THAT THEORY 1153 00:46:57,680 --> 00:47:01,680 BY TRYING TO REGULATE THE 1154 00:47:01,680 --> 00:47:03,240 RESPONSE TO AUTONOMICS USING 1155 00:47:03,240 --> 00:47:05,680 THESE BRAIN REGIONS THAT ARE 1156 00:47:05,680 --> 00:47:07,680 RESPONSIBLE TO TRY TO DAMPEN IT 1157 00:47:07,680 --> 00:47:09,680 TO SEE IF THAT IN AND OF ITSELF 1158 00:47:09,680 --> 00:47:11,520 WILL REDUCE ANXIETY SYMPTOMS OR 1159 00:47:11,520 --> 00:47:13,480 WHETHER IT IS SIMPLY A MARKER OF 1160 00:47:13,480 --> 00:47:19,520 INDIVIDUALS WITH ANXIETY. 1161 00:47:19,520 --> 00:47:20,640 MOVING FURTHER UP THE 1162 00:47:20,640 --> 00:47:21,280 TRANSLATIONAL PIPELINE LET'S 1163 00:47:21,280 --> 00:47:22,560 TALK RESEARCH THAT HAS THE 1164 00:47:22,560 --> 00:47:23,840 POTENTIAL TO MAKE A DIFFERENCE 1165 00:47:23,840 --> 00:47:26,600 IN THE NEAR TERM. THIS IS 1166 00:47:26,600 --> 00:47:27,800 RESEARCH OUT OF OUR DIVISION OF 1167 00:47:27,800 --> 00:47:28,920 SERVICES INTERVENTION RESEARCH, 1168 00:47:28,920 --> 00:47:31,520 LOOKING AT WAYS TO REDUCE 1169 00:47:31,520 --> 00:47:36,040 DURATION OF UNTREATED PSYCHOSIS 1170 00:47:36,040 --> 00:47:37,600 IN REAL WORLD SETTINGS. MANY 1171 00:47:37,600 --> 00:47:38,680 KNOW DATA FROM NUMBER OF 1172 00:47:38,680 --> 00:47:41,040 DIFFERENT STUDIES, MUCH OF IT 1173 00:47:41,040 --> 00:47:43,920 SUPPORTED BY NIMH SHOWSNA THE 1174 00:47:43,920 --> 00:47:45,280 SOONER YOU GET PEOPLE WITH 1175 00:47:45,280 --> 00:47:46,640 PSYCHOSIS INTO TREATMENT DURING 1176 00:47:46,640 --> 00:47:48,480 VERY FIRST EPISODE, THE BETTER 1177 00:47:48,480 --> 00:47:52,040 THEY WILL DO IN THE LONG RUN. SO 1178 00:47:52,040 --> 00:47:56,040 A MAJOR POLICY GOAL IS TO REDUCE 1179 00:47:56,040 --> 00:47:58,400 THE TIME IT TAKES FOR SOMEONE 1180 00:47:58,400 --> 00:48:00,400 WITH A FIRST EPISODES OF 1181 00:48:00,400 --> 00:48:01,600 PSYCHOSIS TO BE RECOGNIZED AS 1182 00:48:01,600 --> 00:48:05,240 HAVING THAT PSYCHOSIS AND TO BE 1183 00:48:05,240 --> 00:48:06,240 REFERRED AND ACTUALLY GO INTO 1184 00:48:06,240 --> 00:48:12,480 TREATMENT. THIS PROGRAM USED A 1185 00:48:12,480 --> 00:48:14,040 COMBINATION OF A NUMBER OF 1186 00:48:14,040 --> 00:48:19,400 DIFFERENT INTERVENTIONS. MOST 1187 00:48:19,400 --> 00:48:22,080 NOTABLY IN AN EFFORT TO ENSURE 1188 00:48:22,080 --> 00:48:24,760 THAT THE HAND OFF FROM TREATMENT 1189 00:48:24,760 --> 00:48:29,960 IS FACILITATED. THE -- TO TEST 1190 00:48:29,960 --> 00:48:33,480 WHETHER THE COMBINATION OF 1191 00:48:33,480 --> 00:48:35,080 INTERVENTIONS CALLED STEP MIGHT 1192 00:48:35,080 --> 00:48:37,680 REDUCE THE TIME IT TAKES TO GET 1193 00:48:37,680 --> 00:48:38,640 PEOPLE INTO TREATMENT, WHAT YOU 1194 00:48:38,640 --> 00:48:40,720 CAN SEE FROM THESE GRAPHS, SORRY 1195 00:48:40,720 --> 00:48:43,160 THE DESIGN OF THIS WAS A SO 1196 00:48:43,160 --> 00:48:48,640 CALLED CLUSTER RANDOMIZED TRIAL 1197 00:48:48,640 --> 00:48:50,840 AND WHERE YOU ARE -- PUTTING 1198 00:48:50,840 --> 00:48:52,440 INTERVENTION INTO SOME SITES AND 1199 00:48:52,440 --> 00:48:56,560 NOT USING ITS IN OTHER SITES 1200 00:48:56,560 --> 00:48:57,760 SITES YOU CHOOSE FOR 1201 00:48:57,760 --> 00:48:58,440 INTERVENTION VERSUS NOT 1202 00:48:58,440 --> 00:48:59,960 RANDOMIZED. THIS ALLOWS YOU TO 1203 00:48:59,960 --> 00:49:01,840 CONDUCT RESEARCH IN COMMUNITY 1204 00:49:01,840 --> 00:49:03,200 BASED SETTINGS AND COMPARE THE 1205 00:49:03,200 --> 00:49:05,720 EFFECT OF THE INTERVENTION TO 1206 00:49:05,720 --> 00:49:07,720 CHANGE IN THE INTERVENTION. YOU 1207 00:49:07,720 --> 00:49:14,480 CAN SEE ACROSS A RANGE OF 1208 00:49:14,480 --> 00:49:20,280 DIFFERENT -- DIFFERENT 1209 00:49:20,280 --> 00:49:21,880 PRESENTING LEVELS THAT THE 1210 00:49:21,880 --> 00:49:23,880 DURATION OF UNTREATED PSYCHOSIS 1211 00:49:23,880 --> 00:49:26,120 WAS REDUCED IN THE INTERVENTION 1212 00:49:26,120 --> 00:49:28,240 SITES COMPARED TO THE CONTROL 1213 00:49:28,240 --> 00:49:34,080 SITES. NEXT SLIDES SLIDE. FINALE 1214 00:49:34,080 --> 00:49:35,440 MORE TREATMENT RELATED STUDY I 1215 00:49:35,440 --> 00:49:36,760 WANTED TO SHARE WITH YOU GIVEN 1216 00:49:36,760 --> 00:49:38,120 WE DO HAVE JUST A COUPLE OF 1217 00:49:38,120 --> 00:49:42,240 MINUTES TO DO IT. MAINTENANCE 1218 00:49:42,240 --> 00:49:43,960 OF WELLNESS IN PATIENTS WITH 1219 00:49:43,960 --> 00:49:46,040 OBSESSIVE COMPULSIVE DISORDER 1220 00:49:46,040 --> 00:49:48,720 HAS BEEN A REAL PROBLEM. IN THAT 1221 00:49:48,720 --> 00:49:55,000 MANY INDIVIDUALS WITH OCD MAY OR 1222 00:49:55,000 --> 00:49:56,480 MAY NOT STAY ON THEIR MEDICINE, 1223 00:49:56,480 --> 00:49:59,920 MANY RELAPSE AND ONE OF THE MAIN 1224 00:49:59,920 --> 00:50:03,280 STAYS OF TREATMENT FOR OCD IS IN 1225 00:50:03,280 --> 00:50:04,760 THE EXPOSURE RESPONSE PREVENTION 1226 00:50:04,760 --> 00:50:07,560 WHICH IS AN EVIDENCE BASED 1227 00:50:07,560 --> 00:50:08,720 PSYCHOTHERAPY, IN FACT SEVERAL 1228 00:50:08,720 --> 00:50:10,440 STUDIES DEMONSTRATED THAT 1229 00:50:10,440 --> 00:50:11,480 EXPOSURE RESPONSE PREVENTION CAN 1230 00:50:11,480 --> 00:50:13,600 BE MORE EFFECTIVE THAN 1231 00:50:13,600 --> 00:50:14,440 MEDICATION AT LEAST OVER THE 1232 00:50:14,440 --> 00:50:20,960 SHORT TERM. SO OF PRACTICAL 1233 00:50:20,960 --> 00:50:24,200 INTEREST TO PRACTICERS IS 1234 00:50:24,200 --> 00:50:26,400 WHETHER YOU CAN SUCCESSFULLY 1235 00:50:26,400 --> 00:50:26,920 DISCONTINUE MEDICATION IN 1236 00:50:26,920 --> 00:50:29,000 INDIVIDUALS WITH OCD WHO HAVE 1237 00:50:29,000 --> 00:50:30,520 BEEN TREATED WITH EXPOSURE 1238 00:50:30,520 --> 00:50:31,800 RESPONSE PREVENTION. SO THIS 1239 00:50:31,800 --> 00:50:32,760 TRIAL ATTEMPTED TO ANSWER THAT 1240 00:50:32,760 --> 00:50:39,360 QUESTION. NEXT SLIDE. THE 1241 00:50:39,360 --> 00:50:41,160 RESULTS WERE, WELL, DECIDEDLY 1242 00:50:41,160 --> 00:50:48,880 MIXED. TO SAY THE LEAST. ONE 1243 00:50:48,880 --> 00:50:51,160 HAND WHAT YOU CAN SEE FROM THE 1244 00:50:51,160 --> 00:50:53,200 DATA HERE IS THAT IN BOTH 1245 00:50:53,200 --> 00:50:55,000 GROUPS, THOSE WHO TAPERED 1246 00:50:55,000 --> 00:50:56,000 MEDICINE AND THOSE WHO CONTINUED 1247 00:50:56,000 --> 00:51:01,640 ON MEDICINE, THERE WAS A GRADUAL 1248 00:51:01,640 --> 00:51:03,920 INCREASE IN SCORE SYMPTOM SCORES 1249 00:51:03,920 --> 00:51:07,680 Y BOX, PRINCIPLE OUTCOME IN 1250 00:51:07,680 --> 00:51:09,320 OBSESSIVE COMPULSIVE SYMPTOMS 1251 00:51:09,320 --> 00:51:18,000 OVER 24 WEEKS OF THE STUDY. OF 1252 00:51:18,000 --> 00:51:23,000 NOTE THOSE WHO CONTINUE THEIR 1253 00:51:23,000 --> 00:51:25,040 MEDICATIONS MAINTAINED SLIGHTLY 1254 00:51:25,040 --> 00:51:28,240 BETTER QUALITY OF LIFE AND 1255 00:51:28,240 --> 00:51:31,120 SATISFACTION SCORES. AND 1256 00:51:31,120 --> 00:51:31,880 SLIGHTLY BETTER DEPRESSION 1257 00:51:31,880 --> 00:51:38,400 RELATED SCORES. SO ALTOGETHER 1258 00:51:38,400 --> 00:51:41,520 THESE DATA SUGGEST THAT THE 1259 00:51:41,520 --> 00:51:44,160 MEDICATION CONTINUES TO PLAY A 1260 00:51:44,160 --> 00:51:48,000 ROLE IN MAINTENANCE OF WELLNESS 1261 00:51:48,000 --> 00:51:48,920 AFTER EXPOSURE RESPONSE 1262 00:51:48,920 --> 00:51:54,040 PREVENTION. THE ADVANTAGE IS 1263 00:51:54,040 --> 00:51:56,440 MODEST SO NOT A HARD RULE TO 1264 00:51:56,440 --> 00:51:57,240 EXPECT PATIENTS TO STAY ON 1265 00:51:57,240 --> 00:51:59,520 MEDICATION BUT AT LEAST WE CAN 1266 00:51:59,520 --> 00:52:00,800 RELIABLY WARN THEM THERE IS 1267 00:52:00,800 --> 00:52:03,040 STILL A ROLE FOR CONTINUING 1268 00:52:03,040 --> 00:52:04,480 MEDICATION AFTER EXPOSURE 1269 00:52:04,480 --> 00:52:05,400 RESPONSE PREVENTION BASED UPON 1270 00:52:05,400 --> 00:52:10,520 THIS DATA. SO THAT IS THE END OF 1271 00:52:10,520 --> 00:52:11,760 MY UPDATE FOR YOU, HOPEFULLY YOU 1272 00:52:11,760 --> 00:52:15,720 GOT A SENSE WHERE WE ARE IN 1273 00:52:15,720 --> 00:52:17,520 TERMS OF INTERACTIONS WITH 1274 00:52:17,520 --> 00:52:18,840 POLICY MAKERS, APPROPRIATIONS 1275 00:52:18,840 --> 00:52:21,720 AND BUDGET, NEWS FROM HHS, NIH 1276 00:52:21,720 --> 00:52:23,160 AND NIMH AND SOME IDEA OF THE 1277 00:52:23,160 --> 00:52:25,200 KIND OF WORK WE SUPPORTED OVER 1278 00:52:25,200 --> 00:52:28,440 THE PAST SEVERAL YEARS AND THE 1279 00:52:28,440 --> 00:52:29,800 RESULTS WHICH HAVE FROM VARIOUS 1280 00:52:29,800 --> 00:52:33,080 DATA THAT I SHOWED YOU FOR LONG 1281 00:52:33,080 --> 00:52:35,640 TERM MEDIUM TERM AND SHORT TERM 1282 00:52:35,640 --> 00:52:37,280 TIME FRAMES FOR IMPACT UPON 1283 00:52:37,280 --> 00:52:38,480 PUBLIC HEALTH. WITH THAT I WILL 1284 00:52:38,480 --> 00:52:41,800 OPEN UP FOR SOME QUESTIONS. YOU 1285 00:52:41,800 --> 00:52:52,320 CAN CUT OUT THE SLIDES. SO WE 1286 00:52:54,240 --> 00:52:54,920 HAVE PLENTY OF TIME FOR 1287 00:52:54,920 --> 00:52:59,880 QUESTIONS AND DISCUSSION. 1288 00:52:59,880 --> 00:53:02,000 >> GO AHEAD TED. 1289 00:53:02,000 --> 00:53:04,960 >> THEY JOSH HOW ARE YOU. THERE 1290 00:53:04,960 --> 00:53:07,200 WAS BLURRINESS. I HAD A QUESTION 1291 00:53:07,200 --> 00:53:12,240 WHEN YOU LOOK AT THE GRAPH WITH 1292 00:53:12,240 --> 00:53:14,640 LOOK AT FUNDAMENTAL RESEARCH AND 1293 00:53:14,640 --> 00:53:16,400 CLINICAL RESEARCH AND DIFFERENT 1294 00:53:16,400 --> 00:53:20,320 PARTS OF THE PORTFOLIO AT NIMH. 1295 00:53:20,320 --> 00:53:22,200 FIRSTLY I LIKE THE WORD 1296 00:53:22,200 --> 00:53:23,880 FUNDAMENTAL IN TERMS OF RESEARCH 1297 00:53:23,880 --> 00:53:26,760 MORE THAN BASIC PREFERENCE, 1298 00:53:26,760 --> 00:53:29,200 DOESN'T MATTER. ONE QUESTION I 1299 00:53:29,200 --> 00:53:31,800 HAD, THAT DOESN'T TAKE INTO 1300 00:53:31,800 --> 00:53:35,000 ACCOUNT BRAIN FUNDED WORK I 1301 00:53:35,000 --> 00:53:36,160 ASSUME. THAT IS I WOULD IMAGINE 1302 00:53:36,160 --> 00:53:39,440 GOING TO FALL LARGELY IN THE ONE 1303 00:53:39,440 --> 00:53:41,160 CATEGORY NIMH SEEMED LIKE WAS 1304 00:53:41,160 --> 00:53:43,880 DROPPING WHICH WAS THE MORE 1305 00:53:43,880 --> 00:53:46,600 FUNDAMENTAL BASIC RESEARCH SIDE. 1306 00:53:46,600 --> 00:53:49,000 SO WONDER IF YOU COULD COMMENT 1307 00:53:49,000 --> 00:53:50,600 ON BRAIN FUNDING AND IS THAT 1308 00:53:50,600 --> 00:53:52,520 CLEARLY HAS A INFLUENCE ON THE 1309 00:53:52,520 --> 00:53:54,480 BROADER FUNDENING THE AREA OF 1310 00:53:54,480 --> 00:53:56,120 MENTAL HEALTH AND IT IS NOT 1311 00:53:56,120 --> 00:53:57,200 TAKEN INTO ACCOUNT IN THAT 1312 00:53:57,200 --> 00:54:01,520 GRAPH. SO FIRST I WANTED A SMALL 1313 00:54:01,520 --> 00:54:03,880 CORRECTION. THE FUNDAMENTAL 1314 00:54:03,880 --> 00:54:05,680 BASIC RESEARCH, THE RESEARCH 1315 00:54:05,680 --> 00:54:06,600 THAT DOESN'T LOOK SPECIFICALLY 1316 00:54:06,600 --> 00:54:09,600 AT DISEASE PROCESSES OR DISEASE 1317 00:54:09,600 --> 00:54:12,120 MODELS IS ACTUALLY INCREASING 1318 00:54:12,120 --> 00:54:12,640 SLOWLY OVER THE LAST -- 1319 00:54:12,640 --> 00:54:14,080 >> I'M SORRY, I GUESS -- 1320 00:54:14,080 --> 00:54:15,400 >> NOT DECREASING. 1321 00:54:15,400 --> 00:54:18,480 IT WAS THE DISEASE FOCUS BASIC 1322 00:54:18,480 --> 00:54:19,720 RESEARCH, THOSE ARE STUDIES THAT 1323 00:54:19,720 --> 00:54:21,440 LOOK AT DISEASE MODELS WHETHER 1324 00:54:21,440 --> 00:54:25,520 ANIMAL MODEL OR TISSUE MODEL OR 1325 00:54:25,520 --> 00:54:29,680 THAT ARE SPECIFIC LOOKING AT 1326 00:54:29,680 --> 00:54:30,800 PATHOPHYSIOLOGICAL HYPOTHESES. 1327 00:54:30,800 --> 00:54:32,160 THAT'S SLIGHTLY DECREASING OVER 1328 00:54:32,160 --> 00:54:33,560 THE LAST THREE TO FOUR YEARS 1329 00:54:33,560 --> 00:54:36,680 AFTER INCREASE PREVIOUS TO THAT. 1330 00:54:36,680 --> 00:54:37,760 BUT WHAT ABOUT BRAIN? YOU ARE 1331 00:54:37,760 --> 00:54:40,520 RIGHT THE DATA THAT I SHOWED YOU 1332 00:54:40,520 --> 00:54:43,320 WAS NON-BRAIN FUNDING. AND MOST 1333 00:54:43,320 --> 00:54:45,600 OF THE BRAIN DOLLARS WOULD 1334 00:54:45,600 --> 00:54:48,960 PROBABLY FIT INTO MOST BRAIN 1335 00:54:48,960 --> 00:54:50,200 DOLLARS OF RELEVANCE WILL 1336 00:54:50,200 --> 00:54:54,360 PROBABLY FIT INTO BASIC 1337 00:54:54,360 --> 00:54:55,960 RESEARCH. THERE ARE NUMBER OF 1338 00:54:55,960 --> 00:54:58,080 BRAIN PROJECTS THAT ARE DISEASE 1339 00:54:58,080 --> 00:54:59,760 FOCUSED INCLUDING SOME THAT ARE 1340 00:54:59,760 --> 00:55:02,720 REALLY IN THE TREATMENT 1341 00:55:02,720 --> 00:55:04,960 DEVELOPMENT SPACE. FOR EXAM IT 1342 00:55:04,960 --> 00:55:06,720 WILL BRAIN FUNDED SEVERAL 1343 00:55:06,720 --> 00:55:09,920 PROJECTS ON EFFECTS ON BOTH 1344 00:55:09,920 --> 00:55:13,120 INVASIVE AND NON-INVASIVE 1345 00:55:13,120 --> 00:55:14,040 INTERVENTIONS THAT BRAIN 1346 00:55:14,040 --> 00:55:18,640 STIMULATION THERAPIES, FOR 1347 00:55:18,640 --> 00:55:20,080 DEPRESSION OCD AND OTHER MENTAL 1348 00:55:20,080 --> 00:55:21,840 ILLNESS DIAGNOSES. SO THERE'S 1349 00:55:21,840 --> 00:55:24,320 SOME DISEASE FOCUSED WORK BOTH 1350 00:55:24,320 --> 00:55:25,920 ON THE CLINICAL SIDE AND BASIC 1351 00:55:25,920 --> 00:55:27,880 SIDE IN BRAIN BUT MOST IS IN 1352 00:55:27,880 --> 00:55:29,840 BASIC SCIENCE. SO IF YOU WOULD 1353 00:55:29,840 --> 00:55:35,760 LOOK AT THOSE EXPENDITURES, 1354 00:55:35,760 --> 00:55:38,040 PROPORTIONALLY, THAT WOULD 1355 00:55:38,040 --> 00:55:40,960 FURTHER SUPPORT RESEARCH IN THE 1356 00:55:40,960 --> 00:55:42,760 BASIC CATEGORY BE IT FUNDAMENTAL 1357 00:55:42,760 --> 00:55:44,200 OR DISEASE FOCUSED. 1358 00:55:44,200 --> 00:55:46,080 >> SEEMS LIKE I GUESS THEN IF 1359 00:55:46,080 --> 00:55:48,280 YOU LOOK OVERALL, THE 1360 00:55:48,280 --> 00:55:51,960 FUNDAMENTAL CLINICAL RESEARCH IS 1361 00:55:51,960 --> 00:55:55,520 REALLY DROPPING. WAS THAT A FAIR 1362 00:55:55,520 --> 00:55:56,200 ASSUMPTION? 1363 00:55:56,200 --> 00:55:58,120 >> YEAH. IF WE CAN -- I DON'T 1364 00:55:58,120 --> 00:55:59,280 KNOW ALEX WE CAN GET THAT SLIDE 1365 00:55:59,280 --> 00:56:03,280 BACK UP. 1366 00:56:03,280 --> 00:56:05,200 >> I THINK IT WAS 80, IF I WROTE 1367 00:56:05,200 --> 00:56:11,240 DOWN A SLIDE NUMBER. 1368 00:56:11,240 --> 00:56:15,040 >> WHAT YOU WILL SEE AS THAT 1369 00:56:15,040 --> 00:56:17,600 COMES UP IS THAT THERE WAS A -- 1370 00:56:17,600 --> 00:56:20,440 THAT CATEGORY OF RESEARCH 1371 00:56:20,440 --> 00:56:22,840 INCREASED IN THE FIRST HALF OF 1372 00:56:22,840 --> 00:56:25,200 THE DECADE OR SO THAT IN THE 1373 00:56:25,200 --> 00:56:27,280 PAST. AND THEN DECREASED AGAIN 1374 00:56:27,280 --> 00:56:32,480 IN THE SECOND HALF. RECEIVE THIS 1375 00:56:32,480 --> 00:56:33,440 IS THE GREEN LINE DISEASE 1376 00:56:33,440 --> 00:56:35,280 RELATED BASIC RESEARCH, SO 1377 00:56:35,280 --> 00:56:38,120 INCREASE IN 2010 TO 2014 I DON'T 1378 00:56:38,120 --> 00:56:41,520 KNOW EXACTLY WHY. THAT INCREASE 1379 00:56:41,520 --> 00:56:43,280 OCCURRED. THEN THERE WAS 1380 00:56:43,280 --> 00:56:45,520 DECREASE. I WANT TO POINT OUT 1381 00:56:45,520 --> 00:56:47,680 THAT EVEN THOUGH THESE NUMBERS 1382 00:56:47,680 --> 00:56:48,960 LOOK LIKE DECREASES OR INCREASES 1383 00:56:48,960 --> 00:56:50,560 AS PERCENT OF TOTAL FUND, EVERY 1384 00:56:50,560 --> 00:56:52,840 SINGLE -- EACH OF THESE THREE 1385 00:56:52,840 --> 00:56:54,280 CATEGORIES HAVE BEEN INCREASING 1386 00:56:54,280 --> 00:56:57,440 IN EXPENDITURES AS THE NIMH 1387 00:56:57,440 --> 00:56:59,000 BUDGET HAS GONE UP. SO IF YOU 1388 00:56:59,000 --> 00:57:00,800 PUT THIS IN REAL DOLLARS THERE 1389 00:57:00,800 --> 00:57:03,200 IS NO DECREASE IN INVESTMENTS IN 1390 00:57:03,200 --> 00:57:04,960 ANY OF THESE THREE AREAS FROM 1391 00:57:04,960 --> 00:57:08,960 2016 TO 2020, ALL INCREASING IN 1392 00:57:08,960 --> 00:57:10,720 THE NUMBER OF DOLLARS THAT ARE 1393 00:57:10,720 --> 00:57:12,200 BEING SPENT. 1394 00:57:12,200 --> 00:57:13,440 >> I GUESS I WOULD ASK A 1395 00:57:13,440 --> 00:57:16,040 FOLLOW-UP QUESTION WHICH IS THAT 1396 00:57:16,040 --> 00:57:17,360 IF DISEASE RELATED BASIC FUNDING 1397 00:57:17,360 --> 00:57:20,120 IS DROPPING, I HEAR WHAT YOU SAY 1398 00:57:20,120 --> 00:57:24,240 ABOUT THE -- EVERYTHING IS 1399 00:57:24,240 --> 00:57:26,000 RISING. BUT RELATIVELY, IT IS 1400 00:57:26,000 --> 00:57:28,280 DROPPING. HOW WILL THAT IMPACT 1401 00:57:28,280 --> 00:57:29,600 OUR ABILITY TO UNDERSTAND 1402 00:57:29,600 --> 00:57:33,840 THERAPIES WHEN WE HAVE THEM? IT 1403 00:57:33,840 --> 00:57:35,160 WOULD SEEMS TO ME WE NEED 1404 00:57:35,160 --> 00:57:36,800 DISEASE RELATED BASIC STUDIES TO 1405 00:57:36,800 --> 00:57:42,760 KNOW THE THERAPIES WE ARE USING 1406 00:57:42,760 --> 00:57:43,680 ARE EFFICACIOUS. 1407 00:57:43,680 --> 00:57:45,000 >> THE ANSWER DEPENDS ON THE 1408 00:57:45,000 --> 00:57:46,440 CAUSE. AND I DON'T THINK WE 1409 00:57:46,440 --> 00:57:50,600 FULLY UNDERSTAND IT YET. BUT LET 1410 00:57:50,600 --> 00:57:52,600 ME STOP YOU AND SAY YEAH IT IS 1411 00:57:52,600 --> 00:57:54,320 DROPPING BUT STILL REMAINS A 1412 00:57:54,320 --> 00:57:55,280 SIGNIFICANT CHUNK OF INVESTMENT, 1413 00:57:55,280 --> 00:57:57,280 EVEN IF YOU LOOK SOLELY BASE OF 1414 00:57:57,280 --> 00:57:59,560 THE CATEGORY THE MAJORITY OF 1415 00:57:59,560 --> 00:58:00,800 FUNDS GOING TOWARDS BASIC 1416 00:58:00,800 --> 00:58:03,040 RESEARCH ARE DISEASE FOCUSED 1417 00:58:03,040 --> 00:58:04,680 AREAS. SO THEY ARE TRYING TO 1418 00:58:04,680 --> 00:58:06,840 LOOK AT ANXIETY, TRYING TO LOOK 1419 00:58:06,840 --> 00:58:08,840 AT MOOD, TRYING TO LOOK AT 1420 00:58:08,840 --> 00:58:11,000 UNDERSTAND COGNITIVE PROCESSES 1421 00:58:11,000 --> 00:58:15,480 THAT GO AWRY IN ILLNESS. SO THAT 1422 00:58:15,480 --> 00:58:16,600 IS FALLENING THE GREEN LINE SO 1423 00:58:16,600 --> 00:58:18,520 IF IT IS DROPPING IT REMAINS A 1424 00:58:18,520 --> 00:58:19,800 SIGNIFICANT CHUNK OF 1425 00:58:19,800 --> 00:58:21,280 EXPENDITURES. SECONDLY, AGAIN AS 1426 00:58:21,280 --> 00:58:23,360 I ARGUED BEFORE WE HAVE REALLY 1427 00:58:23,360 --> 00:58:27,640 BEEN PUSHING AWAY FROM 1428 00:58:27,640 --> 00:58:30,000 INAPPROPRIATELY LABELING BASIC 1429 00:58:30,000 --> 00:58:31,480 STUDIES THAT ARE REALLY SHOULD 1430 00:58:31,480 --> 00:58:34,520 BE FOCUSED ON BASIC HYPOTHESES 1431 00:58:34,520 --> 00:58:36,880 AND NOT CALLING THEM A MODEL OF 1432 00:58:36,880 --> 00:58:38,360 SCHIZOPHRENIA OR MODEL OF AUTISM 1433 00:58:38,360 --> 00:58:40,480 WHERE IT IS INAPPROPRIATE. SO 1434 00:58:40,480 --> 00:58:45,760 SOME OF THAT DROP IS LIKELY DUE 1435 00:58:45,760 --> 00:58:47,280 TO NOT TO CHANGE THE EMPHASIS OF 1436 00:58:47,280 --> 00:58:49,280 SCIENCE BUT CORRECT 1437 00:58:49,280 --> 00:58:50,040 CATEGORIZATION THE LANGUAGE THE 1438 00:58:50,040 --> 00:58:51,480 SCIENCE IS USING. FINALLY THE 1439 00:58:51,480 --> 00:58:52,480 OTHER THING WE ARE DOING IS 1440 00:58:52,480 --> 00:58:55,200 PUSHING PEOPLE TO DO DISEASE 1441 00:58:55,200 --> 00:58:59,960 RELATED RESEARCH IN HUMANS. AND 1442 00:58:59,960 --> 00:59:01,480 THAT HAS SOME PITFALLS WE WILL 1443 00:59:01,480 --> 00:59:02,960 TALK ABOUT WHEN WE GET A LITTLE 1444 00:59:02,960 --> 00:59:07,520 LATER IN THE OPEN PROGRAM WE 1445 00:59:07,520 --> 00:59:08,920 WILL TALK ABOUT PROPOSED WORK 1446 00:59:08,920 --> 00:59:11,440 GROUPS IN HIGH DIMENSIONAL DATA 1447 00:59:11,440 --> 00:59:13,480 SETS BUT WE RECOGNIZE IF WE WANT 1448 00:59:13,480 --> 00:59:14,720 TO UNDERSTAND SCHIZOPHRENIA AND 1449 00:59:14,720 --> 00:59:16,640 AUTISM AND MAJOR DEPRESSIVE 1450 00:59:16,640 --> 00:59:18,480 DISORDER WE NEED A SENSE OF 1451 00:59:18,480 --> 00:59:19,880 NEUROBIOLOGY IN HUMANS AND AS 1452 00:59:19,880 --> 00:59:20,800 OUR TECHNOLOGIES IMPROVE WE CAN 1453 00:59:20,800 --> 00:59:22,760 ANSWER A LOT OF THOSE QUESTIONS 1454 00:59:22,760 --> 00:59:27,040 SO FOR EXAMPLE, FOR WELL OVER 1455 00:59:27,040 --> 00:59:28,200 FIVE YEARS WE HAVE BEEN 1456 00:59:28,200 --> 00:59:30,720 DISCOURAGING GENETIC RESEARCH 1457 00:59:30,720 --> 00:59:32,320 FORWARD GENETIC RESEARCH IN 1458 00:59:32,320 --> 00:59:34,560 RODENTS THAT SEEKS TO TRY TO 1459 00:59:34,560 --> 00:59:35,720 UNDERSTAND THE GENETICS OFFER 1460 00:59:35,720 --> 00:59:38,520 MOOD FOR EXAMPLE, BECAUSE WE CAN 1461 00:59:38,520 --> 00:59:39,800 PERFECTLY WELL DO GENETIC 1462 00:59:39,800 --> 00:59:41,000 STUDIES IN HUMAN BEINGS AND NOT 1463 00:59:41,000 --> 00:59:45,240 JUST TRY TO STUDY SOME ANIMAL 1464 00:59:45,240 --> 00:59:46,640 CORRELATE OF MOOD BUT ACTUALLY 1465 00:59:46,640 --> 00:59:50,120 STUDY DEPRESSION. SO THOSE 1466 00:59:50,120 --> 00:59:51,520 KINDS OF THINGS ARE DELIBERATE 1467 00:59:51,520 --> 00:59:52,880 PUSH FROM A POLICY PERSPECTIVE 1468 00:59:52,880 --> 00:59:54,280 TO TRY TO MOVE SOME OF THE 1469 00:59:54,280 --> 00:59:55,640 DISEASE FOCUS RESEARCH INTO 1470 00:59:55,640 --> 00:59:57,440 HUMAN MODELS. 1471 00:59:57,440 --> 01:00:00,000 >> IT IS WORTH SAYING THAT THE 1472 01:00:00,000 --> 01:00:02,360 KETAMINE CAME FROM PUTTING DRUGS 1473 01:00:02,360 --> 01:00:05,120 ON BRAIN SLICES SO IN USUALLY AT 1474 01:00:05,120 --> 01:00:08,360 LEAST AND IT IS OBVIOUSLY THEN 1475 01:00:08,360 --> 01:00:09,760 WAS APPLIED IN CLINIC THE TERM 1476 01:00:09,760 --> 01:00:11,000 OF TARGET. SOMETHING TO THINK 1477 01:00:11,000 --> 01:00:12,520 ABOUT AND ONE THING THAT MIGHT 1478 01:00:12,520 --> 01:00:14,000 HELP IS TO GRAPH THIS AT SOME 1479 01:00:14,000 --> 01:00:15,280 POINT WITH THE ORANGE AND GREEN 1480 01:00:15,280 --> 01:00:17,360 COMBINED BECAUSE I LIKE YOUR 1481 01:00:17,360 --> 01:00:19,200 POINT, JOSH, I THINK THE POINT 1482 01:00:19,200 --> 01:00:20,320 ABOUT THE FACT THAT SOME OF THE 1483 01:00:20,320 --> 01:00:23,520 DISEASE RELATED BASIC WORK THAT 1484 01:00:23,520 --> 01:00:25,240 FIVE YEARS AGO MIGHT BE COUNTED 1485 01:00:25,240 --> 01:00:27,160 AS DISEASE RELATED BASIC IS NOW 1486 01:00:27,160 --> 01:00:28,880 IN FUNDAMENTAL BASIC CATEGORY 1487 01:00:28,880 --> 01:00:29,640 THAT HELPS UNDERSTAND THE 1488 01:00:29,640 --> 01:00:31,320 CHANGES A LITTLE BIT BETTER. 1489 01:00:31,320 --> 01:00:33,680 >> RIGHT. AND IF YOU DO THAT 1490 01:00:33,680 --> 01:00:35,520 AGAIN WHAT YOU ARE LOOKING AT IS 1491 01:00:35,520 --> 01:00:36,880 INVERSE OF THE BLUE CURVE, YOU 1492 01:00:36,880 --> 01:00:39,520 ARE LOOKING ANYWHERE BETWEEN 50 1493 01:00:39,520 --> 01:00:40,680 AND 60% OF EXPENDITURE IT IS 1494 01:00:40,680 --> 01:00:44,960 LAST DECADE ON THE BASIC SCIENCE 1495 01:00:44,960 --> 01:00:47,800 SIDE. BRIAN. 1496 01:00:47,800 --> 01:00:55,200 >> THANKS. ONE MORE COMMENT. I'M 1497 01:00:55,200 --> 01:00:57,160 GLAD YOU ARE PUSHING IN THIS 1498 01:00:57,160 --> 01:00:59,280 AREA BECAUSE TOO OFTEN THE ONLY 1499 01:00:59,280 --> 01:01:01,120 VOICES AT THE TABLE TALKING 1500 01:01:01,120 --> 01:01:02,280 PORTFOLIO ARE ARGUING WE NEED TO 1501 01:01:02,280 --> 01:01:04,640 BE SPENDING MORE ON CLINICAL 1502 01:01:04,640 --> 01:01:06,160 REALM. IT IS IMPORTANT FOR US TO 1503 01:01:06,160 --> 01:01:07,480 REMEMBER THINGS LIKE THE FACT 1504 01:01:07,480 --> 01:01:09,320 THAT KETAMINE CAME FROM THROWING 1505 01:01:09,320 --> 01:01:10,960 DRUGS ON TO BRAIN SLICES, AND 1506 01:01:10,960 --> 01:01:12,800 THE BASIC RESEARCH IS PLAYING A 1507 01:01:12,800 --> 01:01:14,520 ROLE IN MANY DEVELOPMENTS THAT 1508 01:01:14,520 --> 01:01:17,880 HAVE LED TO NOVEL THERAPIES, 1509 01:01:17,880 --> 01:01:19,600 INCLUDING PSYCHOSOCIAL 1510 01:01:19,600 --> 01:01:20,920 INTERVENTION AS WELL AS DRUG AND 1511 01:01:20,920 --> 01:01:22,480 DEVICE BASED THERAPIES. 1512 01:01:22,480 --> 01:01:23,480 >> THAT PAPER I DON'T REMEMBER 1513 01:01:23,480 --> 01:01:24,920 EXACTLY WHERE IT WAS PUBLISHED 1514 01:01:24,920 --> 01:01:26,120 BUT IT WAS NOW PUBLISHED IN 1515 01:01:26,120 --> 01:01:27,920 NATURE SCIENCE -- NOT PUBLISHED 1516 01:01:27,920 --> 01:01:28,840 IN NATURE SCIENCE OR CELL. 1517 01:01:28,840 --> 01:01:33,000 >> NO IT WAS NOT. 1518 01:01:33,000 --> 01:01:38,840 >> YOU CAN PROBABLY ADD 1519 01:01:38,840 --> 01:01:39,600 (INAUDIBLE) SILL SIGH BEAN TO 1520 01:01:39,600 --> 01:01:41,560 THAT LIST AS WELL. ONE THING I 1521 01:01:41,560 --> 01:01:44,160 WAS STRUCK BY AND GLAD YOU 1522 01:01:44,160 --> 01:01:46,800 PLEASED THAT YOU HIGHLIGHTED IT. 1523 01:01:46,800 --> 01:01:48,760 IS THE CONVERGING EVIDENCE NOW 1524 01:01:48,760 --> 01:01:52,240 OVER MANY YEARS PSILOCYBIN THAT 1525 01:01:52,240 --> 01:01:55,400 AMONG MANY CAUSES OF 1526 01:01:55,400 --> 01:01:56,920 SCHIZOPHRENIA, SYNAPTIC BIOLOGY 1527 01:01:56,920 --> 01:01:58,840 SORT OF FUNDAMENTAL SYNAPTIC 1528 01:01:58,840 --> 01:02:01,040 PROCESSES APPEAR TO BE 1529 01:02:01,040 --> 01:02:03,120 DISREGULATED IN A WAY THAT I 1530 01:02:03,120 --> 01:02:05,120 WOULD SAY IS NOT UNDERSTOOD AT 1531 01:02:05,120 --> 01:02:10,280 ALL BUT CLEARLY IS A CORE 1532 01:02:10,280 --> 01:02:12,160 FEATURE OF THE ILLNESS AND WE 1533 01:02:12,160 --> 01:02:14,920 ARE GETTING -- THERE WAS 1534 01:02:14,920 --> 01:02:17,960 RECENTLY A PAPER PUBLISHED IN 1535 01:02:17,960 --> 01:02:18,960 NATURE SUGGESTING THAT 1536 01:02:18,960 --> 01:02:22,040 INHIBITORY AND EXCITATORY 1537 01:02:22,040 --> 01:02:25,000 NEUROTRANSMISSION IS ALSO 1538 01:02:25,000 --> 01:02:30,720 FUNDAMENTALLY ALTERED IN AUTISM 1539 01:02:30,720 --> 01:02:32,240 FOR YEARS, DECADES, OTHER 1540 01:02:32,240 --> 01:02:33,920 INSTITUTES HAVE BEEN LEADING THE 1541 01:02:33,920 --> 01:02:35,320 CHARGE ON UNDERSTANDING SYNAPTIC 1542 01:02:35,320 --> 01:02:43,880 BIOLOGY. I WONDER IF THIS IS AN 1543 01:02:43,880 --> 01:02:45,240 APPROPRIATE TIME TO STEP BACK 1544 01:02:45,240 --> 01:02:46,640 BECAUSE THERE REALLY -- YOU KNOW 1545 01:02:46,640 --> 01:02:50,920 IT REALLY IS AN AREA THAT IS 1546 01:02:50,920 --> 01:02:52,360 UNDERSTUDY NOW, THERE ARE MANY 1547 01:02:52,360 --> 01:02:54,280 NEW TECHNOLOGIESNA HAVE COME TO 1548 01:02:54,280 --> 01:02:59,160 THE FLOOR SINCE THEN, TARGETED 1549 01:02:59,160 --> 01:03:01,160 PROTEOMICS AND THINGS LIKE THAT 1550 01:03:01,160 --> 01:03:04,000 WHICH CAN GIVE INSIGHTS THAT 1551 01:03:04,000 --> 01:03:08,480 PREVIOUSLY WERE UNATTAINABLE 1552 01:03:08,480 --> 01:03:11,680 WHETHER WHETHER THIS MIGHT BE 1553 01:03:11,680 --> 01:03:13,040 THE TIME TO THINK ABOUT NEW 1554 01:03:13,040 --> 01:03:18,000 INITIATIVES TO FOSTER 1555 01:03:18,000 --> 01:03:19,840 APPLICATIONS. WE GET A 1556 01:03:19,840 --> 01:03:21,480 TREMENDOUS -- AS YOU KNOW A 1557 01:03:21,480 --> 01:03:22,600 TREMENDOUS NUMBER OF 1558 01:03:22,600 --> 01:03:24,440 APPLICATIONS RELATED TO 1559 01:03:24,440 --> 01:03:26,760 CIRCUITRY BASED STUDIES WHICH 1560 01:03:26,760 --> 01:03:30,280 ARE AWESOME, THEY ARE GREAT, I 1561 01:03:30,280 --> 01:03:32,280 LOVE THE THEM. BUT IT IS SUGGESG 1562 01:03:32,280 --> 01:03:34,440 THAT IT IS AT A FINER LEVEL OF 1563 01:03:34,440 --> 01:03:36,800 CIRCUIT NOW THAT WE NEED TO 1564 01:03:36,800 --> 01:03:39,040 FOCUS IN ON HERE. AND WILL 1565 01:03:39,040 --> 01:03:43,040 REALLY ISN'T THE COHORT OF 1566 01:03:43,040 --> 01:03:44,960 INVESTIGATORS THAT WAS AVAILABLE 1567 01:03:44,960 --> 01:03:47,160 SAY 20 YEARS AGO FOR THIS AREA. 1568 01:03:47,160 --> 01:03:49,560 SO WHAT ARE YOUR THOUGHTS ON 1569 01:03:49,560 --> 01:03:49,960 THAT? 1570 01:03:49,960 --> 01:03:53,440 >> BRIAN, I THINK YOU RAISE A 1571 01:03:53,440 --> 01:03:55,520 REALLY IMPORTANT POINT. YOU ARE 1572 01:03:55,520 --> 01:03:58,360 RIGHT, MUCH OF OUR BASIC 1573 01:03:58,360 --> 01:04:02,520 PORTFOLIO, DISEASE FOCUS OR 1574 01:04:02,520 --> 01:04:09,080 FUNDAMENTAL,, HAS MOVED WITH THE 1575 01:04:09,080 --> 01:04:09,760 STAGIEST IN NEUROSCIENCE TO 1576 01:04:09,760 --> 01:04:11,400 FOCUS ON THE ROLE OF 1577 01:04:11,400 --> 01:04:12,600 NEUROSCIENCE AND THAT IS 1578 01:04:12,600 --> 01:04:13,720 INCREDIBLY IMPORTANT WORK, WE 1579 01:04:13,720 --> 01:04:17,360 NEED TO UNDERSTAND THE CIRCUITS 1580 01:04:17,360 --> 01:04:19,280 THAT GOVERN MANY OF OUR 1581 01:04:19,280 --> 01:04:20,880 BEHAVIORS. I THINK THAT CIRCUIT 1582 01:04:20,880 --> 01:04:22,960 WORK IS GOING TO BE REALLY 1583 01:04:22,960 --> 01:04:25,200 IMPORTANT IN ORDER TO KNOW WHERE 1584 01:04:25,200 --> 01:04:29,680 IN THE BRAIN TO LOOK FOR HOW OUR 1585 01:04:29,680 --> 01:04:32,880 DISEASES MANIFESTED. BUT THE 1586 01:04:32,880 --> 01:04:35,320 LOCUST OF DYSFUNCTION OR ONE 1587 01:04:35,320 --> 01:04:37,360 LOCUST OF DYSFUNCTION IN 1588 01:04:37,360 --> 01:04:38,320 SCHIZOPHRENIA QUITE LIKELY AS 1589 01:04:38,320 --> 01:04:41,840 YOU POINTED OUT, OTHERS AS WELL 1590 01:04:41,840 --> 01:04:44,640 IS INDEED IS SYNAPSE. I THINK A 1591 01:04:44,640 --> 01:04:48,360 FOCUS ON REINRIG RATING RESEARCH 1592 01:04:48,360 --> 01:04:49,000 IN SYNAPTIC BIOLOGY WITHIN THE 1593 01:04:49,000 --> 01:04:50,560 CONTEXT OF MENTAL ILLNESS WILL 1594 01:04:50,560 --> 01:04:52,320 BE IMPORTANT TO DO. I WOULD ADD 1595 01:04:52,320 --> 01:04:55,080 TO THAT EXPERTISE, IT WAS 1596 01:04:55,080 --> 01:04:57,440 IMPLICIT WHAT YOU SAID BUT NOT 1597 01:04:57,440 --> 01:04:59,480 EXPLICIT, THAT WE NEED GREATER 1598 01:04:59,480 --> 01:05:02,520 EMPHASIS ON BIOCHEMISTRY, ON THE 1599 01:05:02,520 --> 01:05:03,920 MOLECULAR COMPONENTRY THAT MAKE 1600 01:05:03,920 --> 01:05:05,680 UP OUR CIRCUITS WHETHER AT THE 1601 01:05:05,680 --> 01:05:08,960 SYNAPSE OR OTHER PLACES MANY THE 1602 01:05:08,960 --> 01:05:11,920 CELL. AND I ASSURE YOU OUR 1603 01:05:11,920 --> 01:05:12,960 DIVISION -- STAFF AND DIVISION 1604 01:05:12,960 --> 01:05:16,760 OF NEUROSCIENCE BASIC BEHAVIORAL 1605 01:05:16,760 --> 01:05:18,040 SCIENCES IS LISTENING TO THIS 1606 01:05:18,040 --> 01:05:19,400 AND WILL TAKE THAT INTO ACCOUNT 1607 01:05:19,400 --> 01:05:21,240 AS THEY THINK ABOUT PRIORITIES 1608 01:05:21,240 --> 01:05:30,400 FOR THE COMING YEARS. 1609 01:05:30,400 --> 01:05:33,160 >> THANK YOU, THANKS FOR THE 1610 01:05:33,160 --> 01:05:34,640 OVERVIEW. INTERESTING. EXCITING 1611 01:05:34,640 --> 01:05:37,200 TO SEE THE PRESIDENT STATION 1612 01:05:37,200 --> 01:05:39,280 UNITY AGENDA, CALLING OUT THE 1613 01:05:39,280 --> 01:05:40,600 CRISIS IN MENTAL HEALTHCARE 1614 01:05:40,600 --> 01:05:41,920 ACROSS THE COUNTRY. CAN YOU TELL 1615 01:05:41,920 --> 01:05:44,560 US A BIT MORE ABOUT HOW NIMH 1616 01:05:44,560 --> 01:05:46,480 WILL WORK WITH OTHER AGENCIES 1617 01:05:46,480 --> 01:05:48,960 GIVE US A SENSE OF WHAT THIS 1618 01:05:48,960 --> 01:05:50,200 MEANS? CURIOUS TO KNOW WHAT THIS 1619 01:05:50,200 --> 01:05:51,800 MEANS FOR IMPLEMENTATION SCIENCE 1620 01:05:51,800 --> 01:05:53,640 IN THE NIMH PORTFOLIO FOR 1621 01:05:53,640 --> 01:05:55,400 ENSURING WHAT WE KNOW WORKS 1622 01:05:55,400 --> 01:05:57,280 ACTUALLY MOVES TO THE NEXT STAGE 1623 01:05:57,280 --> 01:05:59,400 OF SCALE UP AND IMPLEMENTATION? 1624 01:05:59,400 --> 01:06:01,680 ANY OTHER INSIGHTS? 1625 01:06:01,680 --> 01:06:02,960 >> LET ME START WITH A LITTLE 1626 01:06:02,960 --> 01:06:07,000 BIT OF HISTORY TO THIS. NIMH HAS 1627 01:06:07,000 --> 01:06:07,560 BEEN CONSULT WIDE THE WHITE 1628 01:06:07,560 --> 01:06:09,920 HOUSE AS EARLY AS DECEMBER AS 1629 01:06:09,920 --> 01:06:12,560 THEY WORKED TO PUT TOGETHER 1630 01:06:12,560 --> 01:06:14,280 THEIR UNITY AGENDA AS PARTS OF 1631 01:06:14,280 --> 01:06:16,960 THEIR CONSULTATION PROCESS WITH 1632 01:06:16,960 --> 01:06:20,960 HHS. AS I MENTION MANY OF THE 1633 01:06:20,960 --> 01:06:24,480 ACTION ITEMS IN THE WHITE HOUSE 1634 01:06:24,480 --> 01:06:26,440 IMPLEMENTATION PLAN WERE ITEMS 1635 01:06:26,440 --> 01:06:28,240 THAT WE SUGGESTED OR OTHER 1636 01:06:28,240 --> 01:06:30,120 AGENCIES SUGGESTED BUT THAT 1637 01:06:30,120 --> 01:06:35,160 BUILD ON EVIDENCE BASE PRACTICES 1638 01:06:35,160 --> 01:06:36,280 THAT Y'ALL ALL THE SCIENTISTS 1639 01:06:36,280 --> 01:06:38,280 OUTS THERE LISTENING HAVE 1640 01:06:38,280 --> 01:06:39,760 PIONEERED OVER THE COURSE OF THE 1641 01:06:39,760 --> 01:06:43,000 LAST COUPLE OF DECADES. SO 1642 01:06:43,000 --> 01:06:44,680 THAT'S BEEN GOOD NEWS AND IT'S 1643 01:06:44,680 --> 01:06:47,520 BEEN WONDERFUL WATCHING THAT 1644 01:06:47,520 --> 01:06:51,160 PROCESS HAPPEN. AS WE MOVE FROM 1645 01:06:51,160 --> 01:06:52,840 THE FACT SHEET TO ACTUALLY 1646 01:06:52,840 --> 01:06:56,440 IMPLEMENTING IT, NIMH IS PART OF 1647 01:06:56,440 --> 01:06:58,800 AN HHS-WIDE TEAM THAT IS BEING 1648 01:06:58,800 --> 01:07:02,560 OVERSEEN BY THE WHITE HOUSE TO 1649 01:07:02,560 --> 01:07:04,360 PUT MANY OF THOSE PLANKS INTO 1650 01:07:04,360 --> 01:07:06,880 ACTION TO FIGURE OUT HOW WE DO 1651 01:07:06,880 --> 01:07:09,480 -- HOW WE EXPAND ACCESS TO 1652 01:07:09,480 --> 01:07:10,360 MENTAL HEALTH AS MUCH ASS IN 1653 01:07:10,360 --> 01:07:13,320 SCHOOLS, HOW DO WE INCREASE THE 1654 01:07:13,320 --> 01:07:15,720 NUMBER OF MENTAL HEALTH 1655 01:07:15,720 --> 01:07:17,320 PRACTICERS AROUND/OR EFFICIENCY 1656 01:07:17,320 --> 01:07:18,880 WHICH THEY CAN RESPOND TO 1657 01:07:18,880 --> 01:07:23,400 CRISES, ET CETERA. SO WE SERVE 1658 01:07:23,400 --> 01:07:26,360 IN THAT WAY MUCH AS ADVISORS. 1659 01:07:26,360 --> 01:07:28,520 AND TRYING TO POINT THE WAY THE 1660 01:07:28,520 --> 01:07:30,080 RESEARCH STUDIES HAVE BEEN 1661 01:07:30,080 --> 01:07:31,960 ALREADY ACCOMPLISHED. THE 1662 01:07:31,960 --> 01:07:33,280 RESEARCH COMPONENT OF THIS PLAN 1663 01:07:33,280 --> 01:07:37,000 HAS BEEN MORE SLOW TO DEVELOP. 1664 01:07:37,000 --> 01:07:40,360 IN THE INITIAL RELEASE THAT WAS 1665 01:07:40,360 --> 01:07:41,680 OUT IN JANUARY, THE ONLY 1666 01:07:41,680 --> 01:07:44,120 RESEARCH COMPONENT WAS THE CALL 1667 01:07:44,120 --> 01:07:46,120 FOR MORE RESEARCH INTO THE 1668 01:07:46,120 --> 01:07:48,800 MENTAL HEALTH IMPACT OF SOCIAL 1669 01:07:48,800 --> 01:07:49,920 MEDIA. BUT THE OFFICE OF SCIENCE 1670 01:07:49,920 --> 01:07:53,560 AND TECHNOLOGY POLICY AS WELL AS 1671 01:07:53,560 --> 01:07:56,240 HHS, HAVE BEEN TRYING TO GUILTY 1672 01:07:56,240 --> 01:07:57,560 GUSH OUT WHAT RESEARCH IS NEEDED 1673 01:07:57,560 --> 01:07:59,960 TO BE ABLE TO ENSURE THAT -- 1674 01:07:59,960 --> 01:08:01,000 FIGURE OUT WHAT RESEARCH IS 1675 01:08:01,000 --> 01:08:03,000 NEEDED TO BE ABLE TO ENSURE THAT 1676 01:08:03,000 --> 01:08:05,280 THESE PLANKS CAN BE FOLLOWED AND 1677 01:08:05,280 --> 01:08:07,040 THERE'S BEEN SOME BACK AND FORTH 1678 01:08:07,040 --> 01:08:09,280 SO FAR WITH NIMH AND AS I 1679 01:08:09,280 --> 01:08:11,080 MENTIONED LAST WEEK, THE 1680 01:08:11,080 --> 01:08:12,880 INCLUSION IN THAT PLAN WAS 1681 01:08:12,880 --> 01:08:15,680 ADDED, THE PLAN WAS A PLANK OF 1682 01:08:15,680 --> 01:08:17,240 THE PLAN WAS ADDED TO FORMULATE 1683 01:08:17,240 --> 01:08:19,640 A RESEARCH AGENDA. SO THAT WILL 1684 01:08:19,640 --> 01:08:22,120 BE A COLLABORATIVE PROCESS WHERE 1685 01:08:22,120 --> 01:08:26,000 WE TALK WHAT EQUITIES WE HAVE 1686 01:08:26,000 --> 01:08:27,480 WHAT EVIDENCE WE HAVE AND WHAT 1687 01:08:27,480 --> 01:08:29,000 WE SEE AS GAPS AND OTHER 1688 01:08:29,000 --> 01:08:30,280 AGENCIES TALK ABOUT WHAT THEY 1689 01:08:30,280 --> 01:08:31,800 SEE AS GAPS IN P OUR RESEARCH 1690 01:08:31,800 --> 01:08:33,600 PORTFOLIO. AND WE HOPE THAT 1691 01:08:33,600 --> 01:08:35,400 ALONG WITH THAT AGENDA WILL COME 1692 01:08:35,400 --> 01:08:37,320 ADDITIONAL RESOURCES TO ENSURE 1693 01:08:37,320 --> 01:08:40,840 WE ACCOMPLISHED THAT. AS I 1694 01:08:40,840 --> 01:08:43,760 MENTIONED ALSO I'M PLEASED THAT 1695 01:08:43,760 --> 01:08:46,680 BOB WILL BE MOVING TO OFFICE OF 1696 01:08:46,680 --> 01:08:48,480 DIRECTOR AT NIMH TO SERVE AS ONE 1697 01:08:48,480 --> 01:08:50,280 OUR CHIEF LIAISONS WITH THESE 1698 01:08:50,280 --> 01:08:53,720 AGENCIES TO ENGAGE IN THIS KIND 1699 01:08:53,720 --> 01:08:55,080 OF BACK AND FORTH DISCUSSION 1700 01:08:55,080 --> 01:08:56,760 ABOUT WHAT WE HAVE TO OFFER AND 1701 01:08:56,760 --> 01:08:58,600 THE WAYS WE NEED TO THINK ABOUT 1702 01:08:58,600 --> 01:09:00,840 FOCUSING OUR SERVICES AND 1703 01:09:00,840 --> 01:09:02,480 INTERVENTION RESEARCH PORTFOLIO 1704 01:09:02,480 --> 01:09:04,160 TO ENSURE WE ANSWER QUESTIONS OF 1705 01:09:04,160 --> 01:09:07,080 USE TO THOSE WHO ARE OUTS THERE 1706 01:09:07,080 --> 01:09:07,840 TRYING TO IMPLEMENT THESE 1707 01:09:07,840 --> 01:09:11,560 PRACTICES. SO I DON'T -- THAT 1708 01:09:11,560 --> 01:09:12,760 MIGHT HAVE BEEN VAGUE. I DON'T 1709 01:09:12,760 --> 01:09:13,840 KNOW IF I HAVE SPECIFIC ANSWERS 1710 01:09:13,840 --> 01:09:15,200 YET TO YOUR QUESTIONS BUT WHAT 1711 01:09:15,200 --> 01:09:16,360 WE CAN ANTICIPATE IS THAT THIS 1712 01:09:16,360 --> 01:09:18,440 IS GOING TO BE AN EXCITING YEAR 1713 01:09:18,440 --> 01:09:20,280 AND YEAR TO COME AND THERE WILL 1714 01:09:20,280 --> 01:09:22,680 BE DEVELOPMENTS IN SPECIFICALLY 1715 01:09:22,680 --> 01:09:23,920 IN THE AREA OF SERVICES 1716 01:09:23,920 --> 01:09:24,840 INTERVENTION RESEARCH THOUGH 1717 01:09:24,840 --> 01:09:26,360 THERE IS INTEREST REALLY ACROSS 1718 01:09:26,360 --> 01:09:32,080 OUR PORTFOLIO. 1719 01:09:32,080 --> 01:09:32,960 >> THANK YOU. 1720 01:09:32,960 --> 01:09:34,960 >> AKNEE THAT, SPEAKING OF ONE 1721 01:09:34,960 --> 01:09:37,120 OF THOSE AGENCIES WE WORK IN A 1722 01:09:37,120 --> 01:09:37,760 BIDIRECTIONAL WAY. 1723 01:09:37,760 --> 01:09:39,720 >> I KNOW YOU ARE WARE BUT TO 1724 01:09:39,720 --> 01:09:41,680 PROGRAM'S QUESTION ABOUT 1725 01:09:41,680 --> 01:09:44,120 IMPLEMENTATION SCIENCE, IT IS A 1726 01:09:44,120 --> 01:09:45,440 SMALL PORTFOLIO BUT WE HAVE BEEN 1727 01:09:45,440 --> 01:09:48,160 WORKING WITH NIMH CLOSELY WHERE 1728 01:09:48,160 --> 01:09:49,760 WE CAN AND EXAMPLE OF THAT IS 1729 01:09:49,760 --> 01:09:52,480 PARTNERING AND IMPLEMENTATION 1730 01:09:52,480 --> 01:09:53,120 SCIENCE RESEARCHERS TOGETHER 1731 01:09:53,120 --> 01:09:55,640 WITH THE CCBHC PROJECT WE HAVE 1732 01:09:55,640 --> 01:09:56,800 LOOKING AT DIFFERENT 1733 01:09:56,800 --> 01:09:57,680 INTERVENTIONS, EVIDENCE BASED 1734 01:09:57,680 --> 01:10:00,760 INTERVENTIONS AND WHAT ARE THE 1735 01:10:00,760 --> 01:10:01,400 BEST PATHWAYS TO ADOPT EVIDENCE 1736 01:10:01,400 --> 01:10:04,040 BASED MEDICINE IN THOSE LARGE 1737 01:10:04,040 --> 01:10:06,560 CLINIC SETTINGS. 1738 01:10:06,560 --> 01:10:08,920 >> ONE OF THE BIGGEST PROGRAMS 1739 01:10:08,920 --> 01:10:11,920 RIGHT NOW IN IMPLEMENTATION SIDE 1740 01:10:11,920 --> 01:10:16,960 IS LEARNING HEALTHCARE SYSTEM 1741 01:10:16,960 --> 01:10:17,560 EPINET LOOK AT FIRST PSYCHOSIS 1742 01:10:17,560 --> 01:10:19,240 AND WE ARE TRYING TO EXPLORE 1743 01:10:19,240 --> 01:10:22,000 WITH ANITA AND OTHERS AT SAMSA, 1744 01:10:22,000 --> 01:10:22,920 OTHER WAYS OF MENTAL HEALTH AS 1745 01:10:22,920 --> 01:10:28,080 WELL. TED. 1746 01:10:28,080 --> 01:10:30,960 >> I WANTED TO COMMENT ON THAT, 1747 01:10:30,960 --> 01:10:33,680 THANKS FOR THE DISCUSSION ABOUT 1748 01:10:33,680 --> 01:10:35,160 THIS, REALLY EXCITING TO HEAR 1749 01:10:35,160 --> 01:10:36,960 ABOUT THE PLANS. THE OTHER THING 1750 01:10:36,960 --> 01:10:43,240 I HAD IS A PIECE OF THIS IS THE 1751 01:10:43,240 --> 01:10:45,600 ARPA, HEALTH ARPA TO ADVANCE 1752 01:10:45,600 --> 01:10:47,200 RESEARCH PROJECT HEALTH AGENCY. 1753 01:10:47,200 --> 01:10:48,960 MAYBE TOTALLY MISPRONOUNCING. 1754 01:10:48,960 --> 01:10:51,000 SORRY. BUT THERE WAS A 1755 01:10:51,000 --> 01:10:51,800 ANNOUNCEMENT WENT AROUND I SAW 1756 01:10:51,800 --> 01:10:55,240 IN ONE OF THE THINGS I SAW ABOUT 1757 01:10:55,240 --> 01:10:59,280 THE MAYBE THE LIST FOR DIRECTOR. 1758 01:10:59,280 --> 01:11:00,080 OR ANNOUNCEMENTS ABOUT IT 1759 01:11:00,080 --> 01:11:01,920 PHYSICAL ESTABLISHMENT, I WAS 1760 01:11:01,920 --> 01:11:03,280 SURPRISED TO NOT SEMEN TALL 1761 01:11:03,280 --> 01:11:06,680 HEALTH THERE. AND THAT WAS 1762 01:11:06,680 --> 01:11:09,400 INTERESTING TO ME AS IT FLEW BY, 1763 01:11:09,400 --> 01:11:09,960 I COULD UNDERSTAND FIND THE 1764 01:11:09,960 --> 01:11:11,160 EXACT READINGS BUT SOMEONE 1765 01:11:11,160 --> 01:11:13,120 COMMENTED AUTISM WASN'T THERE TO 1766 01:11:13,120 --> 01:11:15,120 ME SPECIFICALLY FOR CENTER FOR 1767 01:11:15,120 --> 01:11:17,320 DISABILITY DEVELOPMENT AND I 1768 01:11:17,320 --> 01:11:19,320 REALIZE GENERALLY MENTAL HEALTH 1769 01:11:19,320 --> 01:11:20,640 WASN'T SO THAT SOMETHING I THINK 1770 01:11:20,640 --> 01:11:21,920 WHERE DO YOU SEE THEM IN MENTAL 1771 01:11:21,920 --> 01:11:27,280 HEALTH CRISIS, IN CONNECTING TO 1772 01:11:27,280 --> 01:11:28,520 NIMH? 1773 01:11:28,520 --> 01:11:31,440 >> FIRST THE MORE GENERAL THEN 1774 01:11:31,440 --> 01:11:35,280 MORE SPECIFIC. ARPA H WAS A 1775 01:11:35,280 --> 01:11:40,440 PRIORITY OF THE PRESIDENT, 1776 01:11:40,440 --> 01:11:43,120 GARNERED SUPPORT FROM CONGRESS, 1777 01:11:43,120 --> 01:11:45,520 THE PRESIDENT HAS A SET OF 1778 01:11:45,520 --> 01:11:47,160 HEALTH TALKING POINTS WITH ARPA 1779 01:11:47,160 --> 01:11:49,960 H WHICH INCLUDE DIABETES AND 1780 01:11:49,960 --> 01:11:51,120 CANCER BUT DID NOT INCLUDE 1781 01:11:51,120 --> 01:11:55,800 MENTAL HEALTH. SO IN A LOT OF 1782 01:11:55,800 --> 01:11:57,600 MATERIALS AND ANNOUNCEMENTS AND 1783 01:11:57,600 --> 01:12:00,240 THINGS LIKE THAT, THE INITIALLY 1784 01:12:00,240 --> 01:12:01,760 IDENTIFIED POTENTIAL AREAS OF 1785 01:12:01,760 --> 01:12:03,400 EMPHASIS INCLUDED THE ONES THAT 1786 01:12:03,400 --> 01:12:04,840 THE PRESIDENT IDENTIFIED AND NOT 1787 01:12:04,840 --> 01:12:09,240 MENTAL HEALTH. HOWEVER WE HAVE 1788 01:12:09,240 --> 01:12:11,920 BEEN ASSURED OVER AND OVER ARPA 1789 01:12:11,920 --> 01:12:13,520 H WON'T BE RESTRICTED IN ITS 1790 01:12:13,520 --> 01:12:15,120 FOCUS TO THESE AREAS OF 1791 01:12:15,120 --> 01:12:18,280 PRIORITY. BUT WILL LOOK BROADLY 1792 01:12:18,280 --> 01:12:20,120 ACROSS THE BIOMEDICAL RESEARCH 1793 01:12:20,120 --> 01:12:22,920 PORTFOLIO TO LOOK FOR 1794 01:12:22,920 --> 01:12:25,560 OPPORTUNITIES TO BRING WHAT THEY 1795 01:12:25,560 --> 01:12:28,000 HAVE TO BARE TO ADDRESS ISSUES. 1796 01:12:28,000 --> 01:12:31,000 THAT INCLUDES MENTAL ILLNESS. 1797 01:12:31,000 --> 01:12:34,040 ALL THE NIH INSTITUTES ABOUT A 1798 01:12:34,040 --> 01:12:36,000 YEAR AND A HALF AGO WERE INVITED 1799 01:12:36,000 --> 01:12:37,880 TO SUBMIT IDEAS FOR PROJECTS 1800 01:12:37,880 --> 01:12:40,640 THAT WE FELT WERE ARPA HABLE, 1801 01:12:40,640 --> 01:12:41,680 THAT SOMETHING THAT IS A WORD 1802 01:12:41,680 --> 01:12:45,080 NOW. AND NIMH SUBMITTED THREE 1803 01:12:45,080 --> 01:12:47,040 POTENTIAL IDEAS THERE. ONE 1804 01:12:47,040 --> 01:12:50,000 RELATED TO BIOMARKERS, ONE 1805 01:12:50,000 --> 01:12:54,960 RELATED TO LEARNING HEALTHCARE 1806 01:12:54,960 --> 01:12:57,760 AND ANOTHER ONE RELATED TO GENES 1807 01:12:57,760 --> 01:13:00,600 TO BIOLOGY TRYING TO MAKE THIS 1808 01:13:00,600 --> 01:13:01,600 HIGH THROUGH PUT PROCESS TO 1809 01:13:01,600 --> 01:13:04,960 UNDERSTAND THE BIOLOGICAL 1810 01:13:04,960 --> 01:13:09,560 PATHWAYS IMPLICATED BY GENETIC 1811 01:13:09,560 --> 01:13:11,520 RISK. THERE ARE LOTS OF OTHER 1812 01:13:11,520 --> 01:13:14,000 AREAS WHERE WE MIGHT ENVISION 1813 01:13:14,000 --> 01:13:15,000 ARPA H PLAYING AN IMPORTANT 1814 01:13:15,000 --> 01:13:16,840 ROLE. WE DON'T MOW WHICH WILL BE 1815 01:13:16,840 --> 01:13:18,520 PURSUED BY THE NEW DIRECTOR. THE 1816 01:13:18,520 --> 01:13:20,840 WHOLE POINT OF OF ARPA H IS 1817 01:13:20,840 --> 01:13:23,160 EMPOWER DIRECTOR TO PURSUE OUT 1818 01:13:23,160 --> 01:13:26,920 OF THE BOX IDEAS. IT IS NOT TO 1819 01:13:26,920 --> 01:13:30,640 BE BUSINESS AS USUAL BUT WE HOPE 1820 01:13:30,640 --> 01:13:32,720 AND EXPECT CNS IN GENERAL AND 1821 01:13:32,720 --> 01:13:33,960 MENTAL ILLNESS IN PARTICULAR 1822 01:13:33,960 --> 01:13:36,360 WILL BE AMONG PRIORITIES. WILL 1823 01:13:36,360 --> 01:13:40,840 THEY PLAY A ROLE IN THE FOR 1824 01:13:40,840 --> 01:13:44,040 EXAMPLE THE RESEARCH STRATEGIC 1825 01:13:44,040 --> 01:13:46,200 PLAN THAT I JUST MENTIONED OSTP 1826 01:13:46,200 --> 01:13:46,880 IS LEADING AND NIH IS 1827 01:13:46,880 --> 01:13:48,520 PARTICIPATING IN, THEY MAY WELL, 1828 01:13:48,520 --> 01:13:51,200 THEY ARE NOT YET BECAUSE THEY 1829 01:13:51,200 --> 01:13:52,960 DON'T HAVE ANY STAFF TO DO IT. 1830 01:13:52,960 --> 01:13:56,000 BUT ONE CAN IMAGINE GIVEN HIGH 1831 01:13:56,000 --> 01:13:58,040 PRIORITY THE WHITE HOUSE PUT ON 1832 01:13:58,040 --> 01:13:59,560 MENTAL HEALTH THEY WILL ASK ARPA 1833 01:13:59,560 --> 01:14:01,760 H TO PLAY A ROLE. WE WILL WAIT 1834 01:14:01,760 --> 01:14:06,480 AND SEE. ISH ALSO MENTION A LOT 1835 01:14:06,480 --> 01:14:08,840 OF CONSTITUENCIES PARTICULARLY 1836 01:14:08,840 --> 01:14:12,400 SELF-ADVOCATES ARE WARE OF THE 1837 01:14:12,400 --> 01:14:13,920 GLARING MISS THERE. AND IN THE 1838 01:14:13,920 --> 01:14:15,160 INCLUDING MENTAL HEALTH AMONG 1839 01:14:15,160 --> 01:14:16,520 INITIALLY IDENTIFIED PRIORITIES 1840 01:14:16,520 --> 01:14:20,160 FOR ARPA H AND MAKING THEIR 1841 01:14:20,160 --> 01:14:23,680 VOICES HEARD I'M SURE THEY WON'T 1842 01:14:23,680 --> 01:14:30,840 BE IGNORE. OTHER COMMENTS OR 1843 01:14:30,840 --> 01:14:32,720 QUESTIONS? WE HAVE A FEW MINUTES 1844 01:14:32,720 --> 01:14:34,360 LEFT HERE OPT SCHEDULE OR WE CAN 1845 01:14:34,360 --> 01:14:44,880 GO TO OUR BREAK EARLY. OKAY. I 1846 01:14:46,040 --> 01:14:49,560 THINK THAT WILL DO IT. SORRY. 1847 01:14:49,560 --> 01:14:52,080 >> JUST ONE LAST QUESTION. ALSO 1848 01:14:52,080 --> 01:14:54,680 GOOD TO HEAR ABOUT CONTINUING 1849 01:14:54,680 --> 01:14:56,960 EFFORTS AT NIMH ON DIVERSITY 1850 01:14:56,960 --> 01:14:59,720 EQUITY INCLUSION AND I CAN'T 1851 01:14:59,720 --> 01:15:00,240 REMEMBER WHAT THE A -- 1852 01:15:00,240 --> 01:15:01,920 >> ACCESSIBILITY. 1853 01:15:01,920 --> 01:15:05,960 >> ACCESSIBILITY. AND THE NIMH 1854 01:15:05,960 --> 01:15:09,800 RACIAL ETHNIC EQUITY PLAN, IS 1855 01:15:09,800 --> 01:15:11,720 THERE A EVALUATION FRAMEWORK FOR 1856 01:15:11,720 --> 01:15:13,320 THIS, HOW WILL YOU KNOW WHEN YOU 1857 01:15:13,320 --> 01:15:15,000 ACHIEVED WHAT YOU ARE HOPING TO 1858 01:15:15,000 --> 01:15:15,280 ACHIEVE? 1859 01:15:15,280 --> 01:15:20,120 >> WE HAD TO INCLUDE IN THERE A 1860 01:15:20,120 --> 01:15:22,720 EVALUATION PROCESS. I DON'T 1861 01:15:22,720 --> 01:15:24,480 REMEMBER THE DETAILS OF WHAT WE 1862 01:15:24,480 --> 01:15:28,520 PROPOSE THERE. BUT ONCE OF THE 1863 01:15:28,520 --> 01:15:32,000 MAIN PLAININGS OF EVALUATIONS IS 1864 01:15:32,000 --> 01:15:33,480 DATA AND TRANSPARENCY. JUST AS I 1865 01:15:33,480 --> 01:15:37,480 HAVE BEEN TRANSPARENT TO Y'ALL 1866 01:15:37,480 --> 01:15:39,280 AND PUBLIC WITH REGARD TO FOR 1867 01:15:39,280 --> 01:15:40,520 EXAMPLE SUCCESS RATES BY RACE 1868 01:15:40,520 --> 01:15:42,800 AND ETHNICITY, AND WE ARE 1869 01:15:42,800 --> 01:15:45,600 LOOKING FOR IMPROVEMENT IN THOSE 1870 01:15:45,600 --> 01:15:48,280 IN REDUCTION IN THE GAPS, 1871 01:15:48,280 --> 01:15:52,840 BETWEEN DIFFERENT GROUPS, WE ARE 1872 01:15:52,840 --> 01:15:55,160 ATTEMPTING TO DEVELOP ABILITY TO 1873 01:15:55,160 --> 01:15:56,360 MONITOR THAT IN TERMS OF THE 1874 01:15:56,360 --> 01:15:57,720 DIVERSITY OF OUR WORK FORCE, IN 1875 01:15:57,720 --> 01:16:00,880 TERMS OF FAIRNESS OF LEADERSHIP 1876 01:16:00,880 --> 01:16:02,520 OPPORTUNITIES, OF TRANS-NIH 1877 01:16:02,520 --> 01:16:03,800 ENGAGEMENT AND INVOLVEMENT OF 1878 01:16:03,800 --> 01:16:07,120 AWARDS, ET CETERA. SO THAT IS 1879 01:16:07,120 --> 01:16:08,520 THE -- AMONG THE KINDS OF THINGS 1880 01:16:08,520 --> 01:16:14,160 WE ARE DOING TO LOOK AT THAT. IN 1881 01:16:14,160 --> 01:16:16,440 ADDITION THE FEVS HAS BEEN 1882 01:16:16,440 --> 01:16:19,680 INTRODUCING NEW ITEMS, THAT'S 1883 01:16:19,680 --> 01:16:20,920 THE -- I DON'T REMEMBER WHAT IT 1884 01:16:20,920 --> 01:16:23,200 STANDS FOR BUT THE ANNUAL SURVEY 1885 01:16:23,200 --> 01:16:25,680 GIVEN TO ALL FEDERAL EMPLOYEES 1886 01:16:25,680 --> 01:16:27,320 THAT MEASURES THEIR SATISFACTION 1887 01:16:27,320 --> 01:16:29,520 WITH THE WORKPLACE IN A NUMBER 1888 01:16:29,520 --> 01:16:33,840 OF DIFFERENT AREAS. AND WE ARE 1889 01:16:33,840 --> 01:16:36,880 NOW THE FEDERAL GOVERNMENT IS 1890 01:16:36,880 --> 01:16:37,560 INTRODUCE MORE AND MORE 1891 01:16:37,560 --> 01:16:38,920 QUESTIONS IN THERE THAT MONITOR 1892 01:16:38,920 --> 01:16:43,360 ISSUES OF FAIRNESS. ALSO GIVEN 1893 01:16:43,360 --> 01:16:44,600 US THE ABILITY TO LOOK INTO 1894 01:16:44,600 --> 01:16:47,400 RATINGS OF SATISFACTION IN THESE 1895 01:16:47,400 --> 01:16:48,680 DIFFERENT AREAS AS FUNCTION OF 1896 01:16:48,680 --> 01:16:52,120 INDIVIDUAL RACE AND ETHNICITY. 1897 01:16:52,120 --> 01:16:55,880 SO THAT IS ONE MEASURE OF THE 1898 01:16:55,880 --> 01:16:58,000 INCLUSIVENESS OF THE ATMOSPHERE 1899 01:16:58,000 --> 01:17:00,840 OF THE CULTURE AT NIMH THAT WE 1900 01:17:00,840 --> 01:17:04,120 WILL BE FOLLOWING OVER TIME AS 1901 01:17:04,120 --> 01:17:05,120 WELL. AGAIN WE WILL BE 1902 01:17:05,120 --> 01:17:06,200 TRANSPARENT WITH WHAT WE SHOWED 1903 01:17:06,200 --> 01:17:09,280 THE BASELINE DATA FROM 2020 TO 1904 01:17:09,280 --> 01:17:13,520 OUR EMPLOYEES AT AND ALL HANDS 1905 01:17:13,520 --> 01:17:15,520 MEETING. DID WE DO ALL HANDS? I 1906 01:17:15,520 --> 01:17:16,960 CAN'T REMEMBER BUT WE ARE 1907 01:17:16,960 --> 01:17:18,320 SPREADING THAT INFORMATION 1908 01:17:18,320 --> 01:17:19,960 AROUND AS SORT OF BASELINE 1909 01:17:19,960 --> 01:17:22,000 FEDERAL EMPLOYEE VIEWPOINT 1910 01:17:22,000 --> 01:17:24,400 SURVEY, THANK YOU, SHELLEY AS 1911 01:17:24,400 --> 01:17:25,640 BASELINE MEASURE. SO WE ARE 1912 01:17:25,640 --> 01:17:26,520 ESTABLISHING NUMBER OF DIFFERENT 1913 01:17:26,520 --> 01:17:28,960 WAYS TO EVALUATE THE IMPROVEMENT 1914 01:17:28,960 --> 01:17:30,840 AND CULTURE BOTH FROM A 1915 01:17:30,840 --> 01:17:32,960 QUANTITATIVE DATA PERSPECTIVE 1916 01:17:32,960 --> 01:17:35,440 BUT ALSO FROM A SUBJECT 1917 01:17:35,440 --> 01:17:38,880 EXPERIENCE STANDPOINT. SHELLEY, 1918 01:17:38,880 --> 01:17:41,280 IF YOU HAVE ANYTHING TO ADD, 1919 01:17:41,280 --> 01:17:43,720 WORK ON WHAT THEY ARE DOING IN 1920 01:17:43,720 --> 01:17:44,480 TERMS OF NIH WIDE? 1921 01:17:44,480 --> 01:17:46,480 >> I THINK IT IS A WORK IN 1922 01:17:46,480 --> 01:17:49,440 PROGRESS. THIS IS A FIRST STEP 1923 01:17:49,440 --> 01:17:52,440 AND IT IS ITERATIVE. SO WE ARE 1924 01:17:52,440 --> 01:17:53,760 NOT JUST LEARN OURSELVES HOW TO 1925 01:17:53,760 --> 01:17:55,760 DO A BETTER JOB OF SETTING 1926 01:17:55,760 --> 01:17:57,800 ANGLES AND EVALUATING THEM BUT 1927 01:17:57,800 --> 01:17:59,280 LEARNING FROM OTHER ICs SINCE 1928 01:17:59,280 --> 01:18:03,760 THIS IS A TRANS-NIH EFFO TRANS-. 1929 01:18:03,760 --> 01:18:05,800 >> MAKING THE MILESTONES 1930 01:18:05,800 --> 01:18:06,840 IMPORTANT MAYBE AN IMPORTANT 1931 01:18:06,840 --> 01:18:07,960 ASPECT OF TRANSPARENCY. 1932 01:18:07,960 --> 01:18:09,840 >> WE WILL DO THAT AS WE MOVE 1933 01:18:09,840 --> 01:18:11,240 ALONG. RIGHT NOW WE HAVEN'T 1934 01:18:11,240 --> 01:18:12,240 GOTTEN THE MACHINERY YET TO BE 1935 01:18:12,240 --> 01:18:16,360 ABLE TO DO IT INTERNALLY THOUGH 1936 01:18:16,360 --> 01:18:19,200 FEVS -- I DON'T KNOW IF WE CAN 1937 01:18:19,200 --> 01:18:20,920 RELEASE FEVS DATA OR IF WE DO IT 1938 01:18:20,920 --> 01:18:23,200 NORMALLY, WE DO IT ON INTRAMURAL 1939 01:18:23,200 --> 01:18:24,000 SITES BUT GOOD SUGGESTION, 1940 01:18:24,000 --> 01:18:27,240 PAMELA, THANK YOU. OKAY. IF 1941 01:18:27,240 --> 01:18:28,520 THERE ARE NO FURTHER QUESTIONS 1942 01:18:28,520 --> 01:18:29,960 OR COMMENTS WE ARE SCHEDULED TO 1943 01:18:29,960 --> 01:18:32,200 TAKE A BREAK UNTIL 2:15 WHICH 1944 01:18:32,200 --> 01:18:33,480 POINT I'M EXCITED TO NOTE WE 1945 01:18:33,480 --> 01:18:39,440 WILL HAVE A GUEST SPEAKER DR. 1946 01:18:39,440 --> 01:18:41,640 KATIE MCLAUGHLIN FROM HARVARD 1947 01:18:41,640 --> 01:18:42,720 TALKING STRESS PATHOLOGY IN 1948 01:18:42,720 --> 01:18:47,680 CHILDREN THAT, IS A PARTICULARLY 1949 01:18:47,680 --> 01:18:49,880 TIMELY TOPIC FOR CONSIDERATION. 1950 01:18:49,880 --> 01:18:51,520 WE THOUGHT WE WOULD BRING THIS 1951 01:18:51,520 --> 01:18:52,960 WORK TO YOUR ATTENTION SO LOOK 1952 01:18:52,960 --> 01:18:56,920 FORWARD TO SEEING YOU AT 2:15 IN 1953 01:18:56,920 --> 01:18:58,600 JUST ABOUT 20 MINUTES. WE WILL 1954 01:18:58,600 --> 01:19:00,520 START PROMPTLY THEN. IN THE 1955 01:19:00,520 --> 01:19:01,960 MEANTIME FEEL FREE TO TURN OFF 1956 01:19:01,960 --> 01:19:04,160 YOUR VIDEOS AND MUTE YOURSELVES, 1957 01:19:04,160 --> 01:19:06,880 PLEASE STAY CONNECTED JUST SO 1958 01:19:06,880 --> 01:19:08,280 MISHAPS LIKE THE ONE THAT 1959 01:19:08,280 --> 01:19:09,760 HAPPENED TO ME AT THE BEGINNING 1960 01:19:09,760 --> 01:19:11,360 OF THE SESSION DON'T HAPPEN TO 1961 01:19:11,360 --> 01:19:13,280 YOU AS YOU TRY TO REJOIN. SEE 1962 01:19:13,280 --> 01:19:13,400 YOU SOON. 1963 01:19:13,400 --> 01:19:15,960 >>IT IS MY PLEASURE 1964 01:19:15,960 --> 01:19:18,520 TO WELCOME DR. KATIE MCLAUGHLIN 1965 01:19:18,520 --> 01:19:20,040 TO OUR COUNCIL MEETING. 1966 01:19:20,040 --> 01:19:21,240 PROFESSOR OF PSYCHOLOGY HARVARD 1967 01:19:21,240 --> 01:19:22,920 UNIVERSITY AND SHE JOINED US 1968 01:19:22,920 --> 01:19:25,240 TODAY TO PRESENT ON HER WORK AS 1969 01:19:25,240 --> 01:19:27,440 I MENTIONED EARLIER IS QUITE 1970 01:19:27,440 --> 01:19:29,200 RELEVANT TIMING. I THOUGHT IT 1971 01:19:29,200 --> 01:19:31,560 WOULD BE NICE TO HAVE A MOMENT 1972 01:19:31,560 --> 01:19:33,040 FOR YOU TO HEAR DIRECTLY FROM 1973 01:19:33,040 --> 01:19:35,360 THE SCIENTISTS INSTEAD OF JUST 1974 01:19:35,360 --> 01:19:36,680 FROM MY SCIENCE HIGHLIGHTS THAT 1975 01:19:36,680 --> 01:19:39,200 I PRODUCE EVERY NOW AND THEN. 1976 01:19:39,200 --> 01:19:41,440 AND SO WE CHOSE TO INVITE DR. 1977 01:19:41,440 --> 01:19:45,240 MCLAUGHLIN AS WELL BECAUSE OF 1978 01:19:45,240 --> 01:19:46,680 THE TOO MANICALLINESS OF THE 1979 01:19:46,680 --> 01:19:48,520 TOPIC -- TIMELINESS OF THE TOPIC 1980 01:19:48,520 --> 01:19:49,920 AS WE CONTINUE TO DEAL WITH THE 1981 01:19:49,920 --> 01:19:51,000 PANDEMIC ITSELF AND THE MENTAL 1982 01:19:51,000 --> 01:19:53,240 HEALTH CONSEQUENCES THEREOF, 1983 01:19:53,240 --> 01:19:54,840 THERE IS INCREASING INTEREST ON 1984 01:19:54,840 --> 01:19:56,520 THE PART OF POLICY MAKERS AS 1985 01:19:56,520 --> 01:19:58,000 WELL AS SCIENTISTS AND CARE 1986 01:19:58,000 --> 01:20:00,840 PROVIDERS IN UNDERSTANDING THE 1987 01:20:00,840 --> 01:20:03,040 MENTAL HEALTH IMPACTS OF THE 1988 01:20:03,040 --> 01:20:04,160 PANDEMIC AND THE GENERAL 1989 01:20:04,160 --> 01:20:07,160 POPULATION AND ESPECIALLY IN 1990 01:20:07,160 --> 01:20:08,360 CHILDREN AND ALSO IN 1991 01:20:08,360 --> 01:20:11,440 UNDERSTANDING HOW WE MIGHT BUILD 1992 01:20:11,440 --> 01:20:14,280 RESILIENCE AND COMBAT RISK. SO I 1993 01:20:14,280 --> 01:20:16,480 THOUGHT IT WOULD BE GREAT TO 1994 01:20:16,480 --> 01:20:17,760 HAVE DR. MCLAUGHLIN PRESENT TO 1995 01:20:17,760 --> 01:20:19,680 US TODAY ON STRESS RELATED 1996 01:20:19,680 --> 01:20:21,600 PSYCHOPATHOLOGY IN CHILDREN AND 1997 01:20:21,600 --> 01:20:24,400 ADOLESCENTS DURING COVID-19 1998 01:20:24,400 --> 01:20:26,920 PANDEMIC MECHANISMS OF RISK AND 1999 01:20:26,920 --> 01:20:27,920 RESILIENCE. AND WITH NO FURTHER 2000 01:20:27,920 --> 01:20:30,120 ADIEU, I WILL TURN IT OVER TO 2001 01:20:30,120 --> 01:20:32,960 DR. MCLAUGHLIN, AGAIN AS YOUR -- 2002 01:20:32,960 --> 01:20:34,920 AS YOU LISTEN TO THE TALK AND 2003 01:20:34,920 --> 01:20:36,040 QUESTIONS OR COMMENTS TO MAKE 2004 01:20:36,040 --> 01:20:37,640 ARISE YOU WANT TO PUT THEM INTO 2005 01:20:37,640 --> 01:20:40,200 CHAT WE'LL GO WITH THAT. AND 2006 01:20:40,200 --> 01:20:43,240 OTHERWISE WE WILL HAVE -- TAKE 2007 01:20:43,240 --> 01:20:43,560 QUESTIONS OLE 2008 01:20:43,560 --> 01:20:44,680 >> GREAT. THANKS FOR THE 2009 01:20:44,680 --> 01:20:47,040 INVITATION TO BE HERE. I'M HAPPY 2010 01:20:47,040 --> 01:20:48,520 TO FIELD QUESTIONS ALONG THE WAY 2011 01:20:48,520 --> 01:20:50,920 IF FOLKS WANT TO JUST JUMP IN, 2012 01:20:50,920 --> 01:20:52,480 THE VIEW THAT I HAVE RIGHT NOW I 2013 01:20:52,480 --> 01:20:53,360 DON'T THINK I CAN SEE THE CHAT 2014 01:20:53,360 --> 01:20:54,680 AS IT COMES UP SO PLEASE FEEL 2015 01:20:54,680 --> 01:20:56,120 FREE TO INTERRUPT ME IF YOU HAVE 2016 01:20:56,120 --> 01:20:58,440 QUESTIONS. AS JOSH SAID I'M 2017 01:20:58,440 --> 01:21:01,000 GOING TO SPEAK ABOUT THE ROLE 2018 01:21:01,000 --> 01:21:03,160 THAT STRESS HAS PLAYED AND 2019 01:21:03,160 --> 01:21:04,760 CONTRIBUTING TO THE INCREASES IN 2020 01:21:04,760 --> 01:21:06,360 MENTAL HEALTH PROBLEMS THAT WE 2021 01:21:06,360 --> 01:21:07,920 HAVE OBSERVED DURING THE 2022 01:21:07,920 --> 01:21:10,680 PANDEMIC AMONG CHILDREN AND 2023 01:21:10,680 --> 01:21:11,680 ADOLESCENTS AND THINK A A LITTLE 2024 01:21:11,680 --> 01:21:14,000 BIT ABOUT WHAT THAT'S WE CAN DO 2025 01:21:14,000 --> 01:21:14,840 PLENTIFULLY ABOUT THIS INCREASE 2026 01:21:14,840 --> 01:21:16,640 IN MENTAL HEALTH PROBLEMS. SO IN 2027 01:21:16,640 --> 01:21:20,640 TERMS OF A BRIEF ROAD MAP AROUND 2028 01:21:20,640 --> 01:21:22,040 MENTAL HEALTH, I WILL TALK ABOUT 2029 01:21:22,040 --> 01:21:24,920 INCREASES IN STRESS THAT HAVE 2030 01:21:24,920 --> 01:21:25,600 HAPPENED DURING THE PANDEMIC 2031 01:21:25,600 --> 01:21:27,080 THROUGH THE LENS OF LEADING 2032 01:21:27,080 --> 01:21:28,920 MODELS THAT CAN HELP US TO 2033 01:21:28,920 --> 01:21:31,440 UNDERSTAND IDENTIFY WHICH KIDS 2034 01:21:31,440 --> 01:21:33,320 MIGHT BE MOST VULNERABLE TO 2035 01:21:33,320 --> 01:21:34,440 EXPERIENCING MENTAL HEALTH 2036 01:21:34,440 --> 01:21:36,160 RELATED PROBLEMS AS THE PANDEMIC 2037 01:21:36,160 --> 01:21:37,320 CONTINUES. I'M GOING TO TALK 2038 01:21:37,320 --> 01:21:38,560 ABOUT EMERGING RESEARCH OVER THE 2039 01:21:38,560 --> 01:21:41,200 PAST FEW YEARS, FOCUSED ON 2040 01:21:41,200 --> 01:21:42,360 UNDERSTANDING THE MECHANISMS OF 2041 01:21:42,360 --> 01:21:44,200 RISK AND RESILIENCE TO THE 2042 01:21:44,200 --> 01:21:45,880 STRESS RELATED MENTAL HEALTH 2043 01:21:45,880 --> 01:21:46,560 PROBLEMS WE HAVE SEEN IN 2044 01:21:46,560 --> 01:21:48,080 CHILDREN AND ADOLESCENTS. AND 2045 01:21:48,080 --> 01:21:50,840 I'M GOING TO ADD END BY TALKING 2046 01:21:50,840 --> 01:21:52,000 CLINICAL STRATEGIES WE CAN THINK 2047 01:21:52,000 --> 01:21:54,400 ABOUT IN TERMS OF HOW TO 2048 01:21:54,400 --> 01:21:55,680 INTERVENE TO IMPROVE MENTAL 2049 01:21:55,680 --> 01:21:56,680 HEALTH FOR CHILDREN AND 2050 01:21:56,680 --> 01:21:58,200 ADOLESCENT WHOSE HAVE BEEN MOST 2051 01:21:58,200 --> 01:22:01,600 IMPACTED DURING THE PANDEMIC. SO 2052 01:22:01,600 --> 01:22:03,320 BEFORE I DIVE INTO THE ROLE OF 2053 01:22:03,320 --> 01:22:05,320 STRESS, I WILL BRIEFLY COMMENT 2054 01:22:05,320 --> 01:22:06,560 ON WHAT WE KNOW ABOUT THE 2055 01:22:06,560 --> 01:22:07,720 INCREASES IN MENTAL HEALTH 2056 01:22:07,720 --> 01:22:09,680 PROBLEMS THAT HAVE HAPPENED FOR 2057 01:22:09,680 --> 01:22:10,920 KIDS AND ADOLESCENTS OVER THE 2058 01:22:10,920 --> 01:22:12,840 PAST COUPLE OF YEARS. I'M SURE 2059 01:22:12,840 --> 01:22:14,000 THIS IS NOT GOING TO BE A 2060 01:22:14,000 --> 01:22:16,640 SURPRISE TO ANYONE HERE. I'M 2061 01:22:16,640 --> 01:22:18,080 BRIEFLY TO GOING TO SHOW DATA 2062 01:22:18,080 --> 01:22:21,880 FROM A RECENT META ANALYSIS THAT 2063 01:22:21,880 --> 01:22:23,240 INCLUDED ALMOST 100,000 CHILDREN 2064 01:22:23,240 --> 01:22:25,720 AND ADOLESCENTS. THESE ARE ALL 2065 01:22:25,720 --> 01:22:27,440 SAMPLES THAT WERE COLLECTED 2066 01:22:27,440 --> 01:22:28,240 DURING THE PANDEMIC. WHAT YOU 2067 01:22:28,240 --> 01:22:30,880 CAN SEE HERE IS ACROSS, HOPE YOU 2068 01:22:30,880 --> 01:22:33,400 CAN SEE MY MOUSE, ACROSS THE 2069 01:22:33,400 --> 01:22:35,560 MANY STUDIES CONDUCTED, THE 2070 01:22:35,560 --> 01:22:38,560 ESTIMATE WAS ABOUT 25% OF 2071 01:22:38,560 --> 01:22:41,440 CHILDREN AD LESSENS WERE 2072 01:22:41,440 --> 01:22:42,280 EXPERIENCING CLINICALLY 2073 01:22:42,280 --> 01:22:43,440 SIGNIFICANT DEPRESSION, 2074 01:22:43,440 --> 01:22:45,240 DEPRESSION IN MODERATE TO VEER 2075 01:22:45,240 --> 01:22:48,520 RANGE DURING THE PANDEMIC THESE 2076 01:22:48,520 --> 01:22:50,080 CLINICALLY SIGNIFICANT 2077 01:22:50,080 --> 01:22:51,360 DEPRESSION SYMPTOMS INCREASED AS 2078 01:22:51,360 --> 01:22:52,600 THE PANDEMIC WORE SON SO GOT 2079 01:22:52,600 --> 01:22:55,760 WORSE WITH TIME. AND AS EXPECTED 2080 01:22:55,760 --> 01:22:57,440 HIRING FEMALES HIRING TEENAGERS 2081 01:22:57,440 --> 01:22:59,120 AND CHILDREN. THIS ESTIMATE IS 2082 01:22:59,120 --> 01:23:00,480 ABOUT TWICE WHAT WE SAW BEFORE 2083 01:23:00,480 --> 01:23:03,360 THE PANDEMIC STARTED. WE SEE THE 2084 01:23:03,360 --> 01:23:05,360 SAME PATTERN AND ESTIMATES OF 2085 01:23:05,360 --> 01:23:07,640 CLINICALLY SIGNIFICANT ANXIETY. 2086 01:23:07,640 --> 01:23:09,720 SO HERE THE FULL ESTIMATE IS 2087 01:23:09,720 --> 01:23:11,680 ABOUT 21% OF KIDS AND 2088 01:23:11,680 --> 01:23:12,760 ADOLESCENTS EXPERIENCING 2089 01:23:12,760 --> 01:23:15,800 MODERATE TO SEVERE ANXIETY 2090 01:23:15,800 --> 01:23:21,440 SYMPTOM DURING THE PANDEMIC THE 2091 01:23:21,440 --> 01:23:22,400 CLINICALLY SIGNIFICANT SYMPTOMS 2092 01:23:22,400 --> 01:23:24,120 INCREASE Z AS THE PANDEMIC WORE 2093 01:23:24,120 --> 01:23:25,680 ON, THAT IS IN CONTRAST FROM 2094 01:23:25,680 --> 01:23:27,080 DATA FROM ADULTS WHICH SUGGEST 2095 01:23:27,080 --> 01:23:28,760 IN ADULTS ELEVATIONS AND 2096 01:23:28,760 --> 01:23:29,960 SYMPTOMS WE SAW EARLY ON IN THE 2097 01:23:29,960 --> 01:23:31,280 PANDEMIC HAVE STARTED TO 2098 01:23:31,280 --> 01:23:34,480 DECLINE. AT LEAST THUS FAR IN 2099 01:23:34,480 --> 01:23:36,560 THIS ANALYSIS, WE DON'T SEE THAT 2100 01:23:36,560 --> 01:23:37,560 PATTERN HAPPENING YET WITH 2101 01:23:37,560 --> 01:23:38,480 CHILDREN. I WANT TO MENTION 2102 01:23:38,480 --> 01:23:40,840 THESE INCREASES IN INTERNALIZING 2103 01:23:40,840 --> 01:23:43,640 SYMPTOMS COME AGAINST THE 2104 01:23:43,640 --> 01:23:45,200 BACKDROP OF ALREADY RISING 2105 01:23:45,200 --> 01:23:47,040 LEVELS OF DEPRESSION ANXIETY AND 2106 01:23:47,040 --> 01:23:48,600 SUICIDAL BEHAVIOR IN KIDS AND 2107 01:23:48,600 --> 01:23:50,720 ADOLESCENTS SO THIS IS ONE 2108 01:23:50,720 --> 01:23:52,840 EXAMPLE OF A VERY LARGE TRACKING 2109 01:23:52,840 --> 01:23:54,600 SURVEY THAT'S CONDUCTED ANNUALLY 2110 01:23:54,600 --> 01:23:57,400 FOR MANY YEARS. WHAT YOU SEE IS 2111 01:23:57,400 --> 01:23:58,640 SORT OF RATES OF PAST YEAR 2112 01:23:58,640 --> 01:24:00,520 DEPRESSION BEGINNING TO RISE 2113 01:24:00,520 --> 01:24:02,680 AROUND 2010, ABOUT A 30% 2114 01:24:02,680 --> 01:24:07,000 INCREASE IN THE PREVALENCE OF 2115 01:24:07,000 --> 01:24:08,240 DEPRESSION IN AD LESSENS PRIOR 2116 01:24:08,240 --> 01:24:09,680 TO PANDEMIC SO INCREASE IN 2117 01:24:09,680 --> 01:24:10,840 PSYCHOPATHOLOGY WE SEE DURING 2118 01:24:10,840 --> 01:24:12,080 THE PANDEMIC COME AGAINST A 2119 01:24:12,080 --> 01:24:13,800 BACKDROP OF ALREADY INCREASING 2120 01:24:13,800 --> 01:24:15,400 MENTAL HEALTH PROBLEMS FOR YOUTH 2121 01:24:15,400 --> 01:24:21,040 WHICH I KNOW IS NOT A SURPRISE 2122 01:24:21,040 --> 01:24:22,080 TO ANYONE HERE. TODAY I WILL 2123 01:24:22,080 --> 01:24:24,080 TALK ABOUT THE ROLE THE EXPOSURE 2124 01:24:24,080 --> 01:24:27,240 TO STRESSORS PLAYED IN MENTAL 2125 01:24:27,240 --> 01:24:28,520 HEALTH PROBLEMS AMONG KIDS 2126 01:24:28,520 --> 01:24:29,600 DURING THE PANDEMIC. IT GOES 2127 01:24:29,600 --> 01:24:31,000 WITHOUT SAYING ONE PRIMARY 2128 01:24:31,000 --> 01:24:32,040 EXPERIENCES WE HAVE ALL SHARED 2129 01:24:32,040 --> 01:24:34,400 OVER THE PAST TWO YEARS IS 2130 01:24:34,400 --> 01:24:36,000 INCREASE IN THE AMOUNT OF 2131 01:24:36,000 --> 01:24:37,240 STRESSORS WE HAVE HAD TO 2132 01:24:37,240 --> 01:24:38,640 CONFRONT IN OUR DAILY LIVES SO 2133 01:24:38,640 --> 01:24:40,240 I'M GOING TO TALK ABOUT WHAT I 2134 01:24:40,240 --> 01:24:42,080 MEAN BY STRESS. BEFORE I START 2135 01:24:42,080 --> 01:24:43,480 TALKING ABOUT SOME OF THE RECENT 2136 01:24:43,480 --> 01:24:45,280 DATA. SO STRESSORS INVOLVE 2137 01:24:45,280 --> 01:24:46,400 CHANGES IN ENVIRONMENT, THAT 2138 01:24:46,400 --> 01:24:49,000 REQUIRE US TO ADAPT AND STRESS 2139 01:24:49,000 --> 01:24:51,160 IS TYPICALLY PERCEIVED WHEN THE 2140 01:24:51,160 --> 01:24:53,200 DEMAND FOR SITUATION OUTWEIGH 2141 01:24:53,200 --> 01:24:54,600 OUR ABILITY TO COPE EFFECTIVELY 2142 01:24:54,600 --> 01:24:56,560 WITH THOSE DEMANDS. SO CERTAIN 2143 01:24:56,560 --> 01:24:58,760 TYPES OF ENVIRONMENTAL 2144 01:24:58,760 --> 01:24:59,840 EXPERIENCES ARE PARTICULARLY 2145 01:24:59,840 --> 01:25:02,000 LIKELY TO BE PERCEIVED AS 2146 01:25:02,000 --> 01:25:05,400 STRESSFUL. UNFORTUNATELY THESE 2147 01:25:05,400 --> 01:25:06,280 KINDS OF EXPERIENCES HAVE BEEN 2148 01:25:06,280 --> 01:25:07,040 PARTICULARLY COMMON OVER THE 2149 01:25:07,040 --> 01:25:08,320 PAST COUPLE OF YEARS INCLUDING 2150 01:25:08,320 --> 01:25:11,760 FOR KIDS AND ADOLESCENTS. SO 2151 01:25:11,760 --> 01:25:13,640 FIRST EXPERIENCES IN -- THAT 2152 01:25:13,640 --> 01:25:15,640 INVOLVE THREAT DANGER OR 2153 01:25:15,640 --> 01:25:16,640 POTENTIAL HARMS YOU CAN THINK 2154 01:25:16,640 --> 01:25:18,560 ABOUT THE RISK FOR SERIOUS 2155 01:25:18,560 --> 01:25:20,240 ILLNESS, ONE'S SELF OR LOVED 2156 01:25:20,240 --> 01:25:23,160 ONES FROM THE CORONA VIRUS, 2157 01:25:23,160 --> 01:25:25,520 EXPERIENCES THAT INVOLVE LOTS 2158 01:25:25,520 --> 01:25:26,920 OBVIOUSLY OF LOVED ONES WITH 2159 01:25:26,920 --> 01:25:28,240 NEARLY A MILLION AMERICANS LOST 2160 01:25:28,240 --> 01:25:30,360 OVER THE PAST TWO YEARS, BUT 2161 01:25:30,360 --> 01:25:33,280 ALSO LAWS O OF INCOME STATUS 2162 01:25:33,280 --> 01:25:34,000 EMPLOYMENT CONNECTION TO SCHOOL 2163 01:25:34,000 --> 01:25:36,360 AND SO ON. SITUATION THAT 2164 01:25:36,360 --> 01:25:38,400 INVOLVE UNPREDICTABILITY AND 2165 01:25:38,400 --> 01:25:40,760 UNCONTROLLABILITY WHICH PROBABLY 2166 01:25:40,760 --> 01:25:42,120 DEFINES OUR COLLECTIVE 2167 01:25:42,120 --> 01:25:43,560 EXPERIENCE OVER THE PAST TWO 2168 01:25:43,560 --> 01:25:45,240 YEARS WITH CHANGING HEALTH 2169 01:25:45,240 --> 01:25:46,480 GUIDANCE, MANY PEOPLE 2170 01:25:46,480 --> 01:25:48,400 EXPERIENCING INSECURE ACCESS TO 2171 01:25:48,400 --> 01:25:50,320 FOOD, CHILD CARE, ABILITY TO 2172 01:25:50,320 --> 01:25:52,280 WORK, TO GO TO SCHOOL, 2173 01:25:52,280 --> 01:25:53,360 INTRODUCTION OF VARIANTS AND SO 2174 01:25:53,360 --> 01:25:56,520 ON. UNFAIR TREATMENT RELATED TO 2175 01:25:56,520 --> 01:25:58,240 STIGMA AND DISCRIMINATION WHICH 2176 01:25:58,240 --> 01:26:00,080 WE KNOW HAS INCREASED 2177 01:26:00,080 --> 01:26:01,480 PARTICULARLY FOR ASIAN AND BLACK 2178 01:26:01,480 --> 01:26:03,480 AMERICANS OVER THE PAST TWO 2179 01:26:03,480 --> 01:26:04,560 YEARS DURING THE PANDEMIC. AS 2180 01:26:04,560 --> 01:26:06,440 WELL AS SOCIAL ISOLATION. THESE 2181 01:26:06,440 --> 01:26:08,640 ARE ALL EXPERIENCES THAT ARE 2182 01:26:08,640 --> 01:26:09,680 PARTICULARLY LIKELY TO BE 2183 01:26:09,680 --> 01:26:11,360 PERCEIVED AS STRESSFUL AND 2184 01:26:11,360 --> 01:26:13,800 POWERFUL PREDICTORS OF EMERGENCE 2185 01:26:13,800 --> 01:26:14,920 OF PSYCHOPATHOLOGY SO WHAT I 2186 01:26:14,920 --> 01:26:16,120 WILL TALK ABOUT IS HOW INCREASES 2187 01:26:16,120 --> 01:26:18,240 IN THESE TYPES OF STRESSORS HAS 2188 01:26:18,240 --> 01:26:19,640 BEEN ONE OF THE KEY DRIVERS OF 2189 01:26:19,640 --> 01:26:21,880 THE INCREASES IN PSYCHOPATHOLOGY 2190 01:26:21,880 --> 01:26:22,600 THAT WE HAVE SEEN DURING THE 2191 01:26:22,600 --> 01:26:27,480 PANDEMIC. SO THIS SORT OF 2192 01:26:27,480 --> 01:26:29,120 WIDESPREAD EXPOSURE TO PANDEMIC 2193 01:26:29,120 --> 01:26:30,360 RELATED STRESSORS ALONG WITH 2194 01:26:30,360 --> 01:26:31,960 INCREASE IN MENTAL HEALTH 2195 01:26:31,960 --> 01:26:33,000 PROBLEMS WE HAVE SEEN THE PAST 2196 01:26:33,000 --> 01:26:34,960 TWO YEARS HIGHLIGHTS THE URGENT 2197 01:26:34,960 --> 01:26:37,040 NEED FOR NEW APPROACHES TO 2198 01:26:37,040 --> 01:26:39,240 INTERVENTION, TO PREVENT STRESS 2199 01:26:39,240 --> 01:26:41,160 RELATED PSYCHOPATHOLOGY. SO 2200 01:26:41,160 --> 01:26:42,360 THESE EFFORTS IN MY VIEW SHOULD 2201 01:26:42,360 --> 01:26:44,240 BE GUIDED BY SUBSTANTIAL 2202 01:26:44,240 --> 01:26:46,200 EXISTING THEORY AND RESEARCH ON 2203 01:26:46,200 --> 01:26:47,800 THE LINKS BETWEEN STRESS AND 2204 01:26:47,800 --> 01:26:50,040 PSYCHOPATHOLOGY SO FOR THE 2205 01:26:50,040 --> 01:26:52,120 REMAINDER OF THE TALK I WILL 2206 01:26:52,120 --> 01:26:53,360 WALK THROUGH SEVERAL LEADING 2207 01:26:53,360 --> 01:26:55,720 CONCEPTUAL OR THEORETICAL MODELS 2208 01:26:55,720 --> 01:26:57,360 ABOUT THE RELATIONSHIP BETWEEN 2209 01:26:57,360 --> 01:26:59,600 STRESS AND PSYCHOPATHOLOGY WE 2210 01:26:59,600 --> 01:27:01,560 CAN LEVERAGE, TO UNDERSTAND 2211 01:27:01,560 --> 01:27:02,880 WHICH CHILDREN ARE MOST 2212 01:27:02,880 --> 01:27:05,000 VULNERABLE TO STRESS RELATED 2213 01:27:05,000 --> 01:27:05,640 PSYCHOPATHOLOGY DURING THE 2214 01:27:05,640 --> 01:27:06,920 PANDEMIC, AS WELL AS PRESENT 2215 01:27:06,920 --> 01:27:09,000 SOME EMERGING DATA OVER THE PAST 2216 01:27:09,000 --> 01:27:11,080 COUPLE OF YEARS ABOUT HOW THESE 2217 01:27:11,080 --> 01:27:12,600 FRAME WORKS ARE RELEVANT TO THE 2218 01:27:12,600 --> 01:27:14,320 EXPERIENCES OF KIDS AND AD LESS 2219 01:27:14,320 --> 01:27:15,400 SEPTEMBERS OVER THE PAST SEVERAL 2220 01:27:15,400 --> 01:27:17,400 YEARS -- ADOLESCENTS OVER THE 2221 01:27:17,400 --> 01:27:18,440 PAST SEVERAL YEARS. I WILL 2222 01:27:18,440 --> 01:27:19,880 START BY TALKING ABOUT MODELS 2223 01:27:19,880 --> 01:27:22,800 THAT FOCUS PRIMARILY ON THE 2224 01:27:22,800 --> 01:27:23,760 ENVIRONMENTAL ASPECT OF STRESS. 2225 01:27:23,760 --> 01:27:25,040 SO IN OTHER WORDS, THE 2226 01:27:25,040 --> 01:27:26,240 CHARACTERISTICS OF STRESSFUL 2227 01:27:26,240 --> 01:27:27,920 EXPERIENCES THEMSELVES. AND 2228 01:27:27,920 --> 01:27:29,760 THESE MODELS I WILL ARGUE ARE 2229 01:27:29,760 --> 01:27:31,440 RELEVANT TO UNDERSTANDING WHO 2230 01:27:31,440 --> 01:27:33,320 MIGHT BE MOST VULNERABLE OR MOST 2231 01:27:33,320 --> 01:27:35,280 IN NEED OF INTERVENTION AS A 2232 01:27:35,280 --> 01:27:36,880 FUNCTION OF THE EXPERIENCE THEY 2233 01:27:36,880 --> 01:27:39,120 HAVE HAD DURING THE PANDEMIC. SO 2234 01:27:39,120 --> 01:27:41,200 THESE INCLUDE CUMULATIVE RISK 2235 01:27:41,200 --> 01:27:44,680 MODELS MODELS FOCUS ON SPECIFIC 2236 01:27:44,680 --> 01:27:45,360 TYPE OF STRESSES AND STRESS 2237 01:27:45,360 --> 01:27:46,880 SENSATION MODELS. I WILL WALK 2238 01:27:46,880 --> 01:27:48,160 THROUGH EACH SEPARATELY AND SHOW 2239 01:27:48,160 --> 01:27:50,960 YOU RELEVANT DATA FROM P THE 2240 01:27:50,960 --> 01:27:52,560 PANDEMIC. SO I WILL START 2241 01:27:52,560 --> 01:27:54,000 TALKING CUMULATIVE RISK. SURE 2242 01:27:54,000 --> 01:27:55,600 CUMULATIVE RISK MODELS ARE 2243 01:27:55,600 --> 01:27:57,600 FAMILIAR TO EVERYONE HER HERE. E 2244 01:27:57,600 --> 01:28:00,640 APPROACHES EMERGE FROM EARLY 2245 01:28:00,640 --> 01:28:01,960 WORK IN DEVELOPMENTAL 2246 01:28:01,960 --> 01:28:03,760 PSYCHOPATHOLOGY SHOWING KIDS WHO 2247 01:28:03,760 --> 01:28:04,440 EXPERIENCE MULTIPLE TYPES OF 2248 01:28:04,440 --> 01:28:06,320 STRESS OR ADVERSITY MUCH HIGHER 2249 01:28:06,320 --> 01:28:07,600 RISK FOR DEVELOPING 2250 01:28:07,600 --> 01:28:09,360 PSYCHOPATHOLOGY PERHAPS 2251 01:28:09,360 --> 01:28:10,120 UNSURPRISINGLY KIDS WHO 2252 01:28:10,120 --> 01:28:13,000 EXPERIENCE A SMALLER NUMBER OF 2253 01:28:13,000 --> 01:28:15,080 STRESSORS. THE BASIC IDEA IS AS 2254 01:28:15,080 --> 01:28:16,920 YOUR EXPOSURE TO STRESS 2255 01:28:16,920 --> 01:28:19,280 INCREASES, SO DOES LIKELIHOOD OF 2256 01:28:19,280 --> 01:28:20,160 PSYCHOPATHOLOGY, THE IDEA IN 2257 01:28:20,160 --> 01:28:22,280 THESE MODELS IS AN ADDITIVE 2258 01:28:22,280 --> 01:28:23,400 AFFECT THAT AS STRESS 2259 01:28:23,400 --> 01:28:24,280 ACCUMULATES SO DOES THE 2260 01:28:24,280 --> 01:28:25,400 VULNERABILITY TO DEVELOPING 2261 01:28:25,400 --> 01:28:30,840 PSYCHOPATHOLOGY. I WILL SHOW 2262 01:28:30,840 --> 01:28:32,840 YOU DATA FROM MY LAB THOUGH 2263 01:28:32,840 --> 01:28:34,720 EVIDENCE FOR CUMULATIVE IMPACT 2264 01:28:34,720 --> 01:28:36,200 OF PANDEMIC RELATED STRESSORS ON 2265 01:28:36,200 --> 01:28:37,480 MENTAL HEALTH DOCUMENTED IN KIDS 2266 01:28:37,480 --> 01:28:42,040 AND ADULTS DURING THE PANDEMIC. 2267 01:28:42,040 --> 01:28:43,720 SO I WILL TALK LONGITUDINAL 2268 01:28:43,720 --> 01:28:44,800 QUESTION WHERE WE OBSERVE IN 2269 01:28:44,800 --> 01:28:46,160 CHILDREN AN ADOLESCENTS AND 2270 01:28:46,160 --> 01:28:47,320 DESIGNS FOR ME TO REFERENCE 2271 01:28:47,320 --> 01:28:50,640 STUDY NUMBER OF TIMES THROUGHOUT 2272 01:28:50,640 --> 01:28:52,600 THE TALK. WE ARE IN THE MIDST OF 2273 01:28:52,600 --> 01:28:54,720 CONDUCTING SEVERAL LONGITUDINAL 2274 01:28:54,720 --> 01:28:56,640 STUDIES OF MENTAL HEALTH IN 2275 01:28:56,640 --> 01:28:58,600 CHILDREN AND AD LESSENS WHERE WE 2276 01:28:58,600 --> 01:29:00,240 HAD RICH DATA, ON HOW THESE 2277 01:29:00,240 --> 01:29:00,960 CHILDREN WERE FUNCTIONING PRIOR 2278 01:29:00,960 --> 01:29:03,000 TO THE PANDEMIC. PRETTY CLOSE IN 2279 01:29:03,000 --> 01:29:04,240 TIME TO WHEN THE PANDEMIC 2280 01:29:04,240 --> 01:29:06,640 STARTED. WE WERE ABLE TO FOLLOW 2281 01:29:06,640 --> 01:29:08,480 THESE CHILDREN AND THEIR 2282 01:29:08,480 --> 01:29:09,880 FAMILIES, AT TWO POINTS IN THE 2283 01:29:09,880 --> 01:29:11,920 EARLY PHASE OF THE PANDEMIC AND 2284 01:29:11,920 --> 01:29:13,400 THE FIRST IN THE INITIAL PHASE 2285 01:29:13,400 --> 01:29:15,160 DURING THE PERIOD OF TIME MOST 2286 01:29:15,160 --> 01:29:17,560 WERE IN LOCK DOWN AND APRIL 2287 01:29:17,560 --> 01:29:18,560 2020, SO IN ADDITION TO LOOKING 2288 01:29:18,560 --> 01:29:20,320 AT MENTAL HEALTH WE ASSESSED 2289 01:29:20,320 --> 01:29:22,560 PANDEMIC RELATED STRESSORS IN A 2290 01:29:22,560 --> 01:29:23,920 RANGE OF RISK OF PROTECTIVE 2291 01:29:23,920 --> 01:29:25,320 FACTORS AND WE DID THE SAME 2292 01:29:25,320 --> 01:29:27,280 AGAIN IN WHAT I'M CALLING WHAT 2293 01:29:27,280 --> 01:29:30,120 WILL HOPEFULLY BE MID PANDEMIC, 2294 01:29:30,120 --> 01:29:31,200 HARD TO NOTICE POINT BUT THIS 2295 01:29:31,200 --> 01:29:34,400 WAS FALL 2020, NOVEMBER AROUND 2296 01:29:34,400 --> 01:29:37,440 THE TIME OF THE ELECTION. SO 2297 01:29:37,440 --> 01:29:39,680 BECAUSE EXISTING MEASURE OF 2298 01:29:39,680 --> 01:29:40,480 PANDEMIC RELATED STRESS DIP 2299 01:29:40,480 --> 01:29:42,080 EXIST WE CREATED ONE. THAT 2300 01:29:42,080 --> 01:29:43,760 INCLUDED ITEMS RELEVANT TO 2301 01:29:43,760 --> 01:29:45,080 EXPERIENCES THAT FAMILIES WERE 2302 01:29:45,080 --> 01:29:46,200 FACING DURING THE EARLY PHASE OF 2303 01:29:46,200 --> 01:29:48,120 THE PANDEMIC. THIS IS A COMMON 2304 01:29:48,120 --> 01:29:51,280 PRACTICE IN THE FIELD WHEN 2305 01:29:51,280 --> 01:29:52,360 UNIQUE STRESSORS LIKE DISASTER 2306 01:29:52,360 --> 01:29:54,320 OR TERRORIST ATTACK HAPPEN WHERE 2307 01:29:54,320 --> 01:29:56,240 THERE ARE EXPERIENCES UNIQUE TO 2308 01:29:56,240 --> 01:29:57,200 THAT PARTICULAR EVENT LIKE 2309 01:29:57,200 --> 01:29:59,400 HAVING TO SLEEP IN THE SUPERDOME 2310 01:29:59,400 --> 01:30:00,640 DURING HURRICANE KATRINA, SO 2311 01:30:00,640 --> 01:30:02,880 WHEN OUR STRESSOR ASSESSMENT WE 2312 01:30:02,880 --> 01:30:04,400 INCLUDED HEALTH RELATED 2313 01:30:04,400 --> 01:30:05,800 STRESSORS THINGS LIKE HAVING A 2314 01:30:05,800 --> 01:30:06,920 FAMILY MEMBER OR LOVED ONE 2315 01:30:06,920 --> 01:30:10,320 CONTRACT COVID OR DIE OF COVID, 2316 01:30:10,320 --> 01:30:11,920 SOCIAL STRESSORS, BEING ISOLATED 2317 01:30:11,920 --> 01:30:13,320 EXPERIENCING DISCRIMINATION OR 2318 01:30:13,320 --> 01:30:15,320 HAVING CONFLICT WITH SOMEONE WHO 2319 01:30:15,320 --> 01:30:16,680 WAS IN YOUR HOME, FINANCIAL 2320 01:30:16,680 --> 01:30:19,680 STRESSORS LIKE HAVING PARENT 2321 01:30:19,680 --> 01:30:20,680 LOSE JOB OR INCOME OR 2322 01:30:20,680 --> 01:30:22,280 EXPERIENCING FOOD INSECURITY, 2323 01:30:22,280 --> 01:30:26,200 CHALLENGES WITH SCHOOL. SO KIDS 2324 01:30:26,200 --> 01:30:27,280 HAD DIFFICULTY ENGAGING OR 2325 01:30:27,280 --> 01:30:29,360 PARTICIPATING IN REMOTE 2326 01:30:29,360 --> 01:30:30,000 SCHOOLDAYS BECAUSE THEY DIDN'T 2327 01:30:30,000 --> 01:30:31,480 HAVE A QUIET PLACE TO WORK AND 2328 01:30:31,480 --> 01:30:32,680 ASPECT OF THE PHYSICAL 2329 01:30:32,680 --> 01:30:34,120 ENVIRONMENT LIKE BEING IN A 2330 01:30:34,120 --> 01:30:40,000 CROWDED HOUSE. SO PERHAPS 2331 01:30:40,000 --> 01:30:40,760 UNSURPRISINGLY WE BEFORE I TALK 2332 01:30:40,760 --> 01:30:42,200 ABOUT THESE FIGURE IS WILL SAY 2333 01:30:42,200 --> 01:30:43,200 THAT IN OUR DATA, VERY SIMILAR 2334 01:30:43,200 --> 01:30:47,520 TO THE META ANALYSIS I SHOWED 2335 01:30:47,520 --> 01:30:50,480 YOU WE SAW A DOUBLING OF 2336 01:30:50,480 --> 01:30:51,800 SYMPTOMS INTERNALIZING AND 2337 01:30:51,800 --> 01:30:53,280 EXTERNALIZING PROBLEMS IN THESE 2338 01:30:53,280 --> 01:30:54,120 KIDS DURING PANDEMIC RELATIVE TO 2339 01:30:54,120 --> 01:30:55,560 HOW THEY WERE DOING BEFORE THE 2340 01:30:55,560 --> 01:30:57,080 PANDEMIC STARTED. OF ALL OF THE 2341 01:30:57,080 --> 01:30:58,920 RISK FACTORS THAT WE ASSESSED IN 2342 01:30:58,920 --> 01:31:00,840 OUR SURVEY BY FAR THE FACTOR 2343 01:31:00,840 --> 01:31:02,360 MOST STRONGLY PREDICTED WHETHER 2344 01:31:02,360 --> 01:31:03,800 KIDS DEVELOPED INCREASING 2345 01:31:03,800 --> 01:31:05,800 SYMPTOMS OF PSYCHOPATHOLOGY WAS 2346 01:31:05,800 --> 01:31:07,480 THE DEGREE OF THEIR EXPOSURE TO 2347 01:31:07,480 --> 01:31:08,240 THESE PANDEMIC RELATED 2348 01:31:08,240 --> 01:31:10,120 STRESSORS. YOU CAN SEE THAT 2349 01:31:10,120 --> 01:31:11,720 CLEARLY IN THESE FIGURES AS 2350 01:31:11,720 --> 01:31:13,040 PANDEMIC RELATED STRESSORS 2351 01:31:13,040 --> 01:31:14,560 INCREASED, SO DID THE LIKELIHOOD 2352 01:31:14,560 --> 01:31:16,080 OF DEVELOPING INTERNALIZING 2353 01:31:16,080 --> 01:31:18,120 SYMPTOMS IN THE EARLY PHASE OF 2354 01:31:18,120 --> 01:31:20,480 THE PANDEMIC RELATIVE TO HOW YOU 2355 01:31:20,480 --> 01:31:22,160 -- HOW MANY SYMPTOMS YOU HAD 2356 01:31:22,160 --> 01:31:24,120 PRIOR TO PANDEMIC, AS WELL AS 2357 01:31:24,120 --> 01:31:25,240 YOUR SYMPTOMS LATER ON IN THE 2358 01:31:25,240 --> 01:31:26,800 PANDEMIC. RELATIVE TO WHERE YOU 2359 01:31:26,800 --> 01:31:28,480 WERE WHEN THE PANDEMIC FIRST 2360 01:31:28,480 --> 01:31:30,680 STARTED, WE SEE THE EXACT SAME 2361 01:31:30,680 --> 01:31:32,040 PATTERN LOOKING AT EXTERNALIZING 2362 01:31:32,040 --> 01:31:35,120 SYMPTOMS. SO SORT OF THE BUILD 2363 01:31:35,120 --> 01:31:36,520 RESPONSE RELATIONSHIP BETWEEN 2364 01:31:36,520 --> 01:31:37,600 PANDEMIC RELATED STRESS AND 2365 01:31:37,600 --> 01:31:39,360 SYMPTOMS OF PSYCHOPATHOLOGY. I 2366 01:31:39,360 --> 01:31:41,720 WILL SAY THAT THESE RESULTS HAVE 2367 01:31:41,720 --> 01:31:43,200 BEEN REPLICATED IN MANY CONTACTS 2368 01:31:43,200 --> 01:31:44,840 LONGITUDINAL SAMPLES OF KIDS 2369 01:31:44,840 --> 01:31:47,760 ADOLESCENTS AND ADULTS ACROSS 2370 01:31:47,760 --> 01:31:49,840 MANY CULTURAL CONTACTS, CHILDREN 2371 01:31:49,840 --> 01:31:52,760 FROM CHINA, ROMANIA, OTHER PARTS 2372 01:31:52,760 --> 01:31:53,720 OF EUROPE DURING THE PANDEMIC SO 2373 01:31:53,720 --> 01:31:54,760 THESE ARE ROBUST APPROXIMATE 2374 01:31:54,760 --> 01:31:57,840 REPLICABLE EFFECTS. SO SECOND 2375 01:31:57,840 --> 01:32:00,080 SET OF MODELS FOCUSES ON HOW 2376 01:32:00,080 --> 01:32:02,840 SPECIFIC TYPES OF STRESSORS 2377 01:32:02,840 --> 01:32:04,280 MIGHT BE PARTICULARLY LIKELY TO 2378 01:32:04,280 --> 01:32:06,040 CONTRIBUTE TO PSYCHOPATHOLOGY. 2379 01:32:06,040 --> 01:32:07,920 SO ACTUALLY RATHER THAN JUST 2380 01:32:07,920 --> 01:32:09,440 TALKING AT YOU FOR THE NEXT 30 2381 01:32:09,440 --> 01:32:10,960 MINUTES I LOVE TO GET A LITTLE 2382 01:32:10,960 --> 01:32:11,960 AUDIENCE PARTICIPATION JUST ON 2383 01:32:11,960 --> 01:32:13,880 THIS ONE SO YOU CAN LIKE USE THE 2384 01:32:13,880 --> 01:32:15,800 CHAT, NOT SURE I WILL SEE IT, 2385 01:32:15,800 --> 01:32:17,800 JUST SHOUT OUT, CURIOUS IF YOU 2386 01:32:17,800 --> 01:32:19,360 WERE GOING TO GUESS THE KIND OF 2387 01:32:19,360 --> 01:32:21,400 STRESSOR EXPERIENCED OVER THE 2388 01:32:21,400 --> 01:32:23,560 PAST YEAR LIKE HEALTH STRESSOR, 2389 01:32:23,560 --> 01:32:26,240 ECONOMIC STRESSOR, STRESSORS OF 2390 01:32:26,240 --> 01:32:28,520 DAILY LIFE LOSS, WHATTED YOU 2391 01:32:28,520 --> 01:32:29,280 GUESS THE KIND OF STRESS THAT 2392 01:32:29,280 --> 01:32:31,760 MIGHT -- MOST STRONGLY PREDICTED 2393 01:32:31,760 --> 01:32:33,560 PSYCHOPATHOLOGY IN EITHER ADULTS 2394 01:32:33,560 --> 01:32:35,280 OR KIDS? CURIOUS WHAT FOLKS 2395 01:32:35,280 --> 01:32:40,240 THINK BEFORE I TELL YOU. 2396 01:32:40,240 --> 01:32:40,880 >> SCHOOL CLOSURES. 2397 01:32:40,880 --> 01:32:42,120 >> OKAY. 2398 01:32:42,120 --> 01:32:42,560 >> ABUSE. 2399 01:32:42,560 --> 01:32:45,880 >> YES. 2400 01:32:45,880 --> 01:32:47,760 >> YES, EXPOSURE TO VIOLENCE. 2401 01:32:47,760 --> 01:32:49,080 >> DAYSLY DISRUPTION. 2402 01:32:49,080 --> 01:32:51,480 >> MR. DAILY DISRUPTION. . 2403 01:32:51,480 --> 01:32:52,800 >> WHAT IS INTERESTING BEFORE I 2404 01:32:52,800 --> 01:32:53,800 SHOW YOU THE DATA FROM THE 2405 01:32:53,800 --> 01:32:55,080 PANDEMIC I WILL SHOW YOU LATE 2406 01:32:55,080 --> 01:32:58,240 DATA FROM ADULTS AND KIDS, WHEN 2407 01:32:58,240 --> 01:32:59,880 THESE KINDS OF STRESSES HAPPEN 2408 01:32:59,880 --> 01:33:00,920 LIKE NATURAL DISASTERS, 2409 01:33:00,920 --> 01:33:04,960 TERRORIST ATTACKS, PEOPLE OFTEN 2410 01:33:04,960 --> 01:33:07,200 FOCUS ON THE THREAT TO ONE 2411 01:33:07,200 --> 01:33:08,600 PHYSICAL SAFETY THAT HAPPENS IN 2412 01:33:08,600 --> 01:33:10,520 THESE KINDS OF EVENTS AND ASSUME 2413 01:33:10,520 --> 01:33:12,720 THESE ARE THE KINDS OF STRESSORS 2414 01:33:12,720 --> 01:33:14,360 THAT HAVE BIGGEST IMPACT ON 2415 01:33:14,360 --> 01:33:15,120 PSYCHOPATHOLOGY, WHAT IS 2416 01:33:15,120 --> 01:33:16,560 INTERESTING IN PRIOR STUDIES IS 2417 01:33:16,560 --> 01:33:17,840 THAT WHAT FOLKS TEND TO SEE IS 2418 01:33:17,840 --> 01:33:20,160 THAT ACTUALLY THE SORT OF MORE 2419 01:33:20,160 --> 01:33:22,880 CHRONIC OR DISRUPT DAILY 2420 01:33:22,880 --> 01:33:24,280 DISRUPTIONS TO LIFE WHETHER 2421 01:33:24,280 --> 01:33:26,000 SCHOOL CLOSURE NOT GOING TO 2422 01:33:26,000 --> 01:33:27,760 SCHOOL OR INTERACT WITH YOUR 2423 01:33:27,760 --> 01:33:29,000 PEERS, THAT HAVE STRONGEST 2424 01:33:29,000 --> 01:33:31,360 IMPACT ON PSYCHOPATHOLOGY AND 2425 01:33:31,360 --> 01:33:32,920 YOU SEE THAT MIRED IN DATA 2426 01:33:32,920 --> 01:33:34,280 COLLECTED IN ADULTS, YOUNG 2427 01:33:34,280 --> 01:33:35,600 ADULTS AT THE BEGINNING OF 2428 01:33:35,600 --> 01:33:36,920 PANDEMIC. I WILL SHOW YOU DATA 2429 01:33:36,920 --> 01:33:38,520 ON KIDS NEXT. YOU CAN'T SEE THE 2430 01:33:38,520 --> 01:33:40,160 FULL SCALE, I WILL REVEAL FROM A 2431 01:33:40,160 --> 01:33:41,920 MOMENT BUT WHAT IS PLOTTED HERE 2432 01:33:41,920 --> 01:33:43,800 EFFECT SIZES THE BLACK LINE IS 2433 01:33:43,800 --> 01:33:45,560 0, ANYTHING TO THE RIGHT IS AN 2434 01:33:45,560 --> 01:33:47,680 EFFECT SIZE THAT'S LARGER THAN 2435 01:33:47,680 --> 01:33:49,640 0, AND WHAT YOU CAN SEE IS THAT 2436 01:33:49,640 --> 01:33:52,040 THIS IS COHORT OF YOUNG ADULTS 2437 01:33:52,040 --> 01:33:53,960 20 BEFORE THE PANDEMIC AND 22 2438 01:33:53,960 --> 01:33:56,040 WHEN THIS ASSESSMENT WAS 2439 01:33:56,040 --> 01:33:56,960 PERFORMED AT THE BEGINNING OF 2440 01:33:56,960 --> 01:33:58,400 THE PANDEMIC. THESE ARE HEALTH 2441 01:33:58,400 --> 01:34:00,040 RELATED RISKS. SO THINGS LIKE 2442 01:34:00,040 --> 01:34:01,680 RISK TO YOUR OWN HEALTH RISK TO 2443 01:34:01,680 --> 01:34:03,360 THE HEALTH OF YOUR LOVED ONES 2444 01:34:03,360 --> 01:34:07,000 AND YOU CAN SEE THERE'S 2445 01:34:07,000 --> 01:34:08,920 CONSISTENT FAIRLY SMALL EFFECTS 2446 01:34:08,920 --> 01:34:10,440 ON PERCEPTIONS OF STRESS AND 2447 01:34:10,440 --> 01:34:12,240 SYMPTOM TOMS OF ANXIETY AND 2448 01:34:12,240 --> 01:34:14,320 DEPRESSION FOR THESE STRESSORS 2449 01:34:14,320 --> 01:34:16,200 BUT THEY ARE DWARFED BY THE 2450 01:34:16,200 --> 01:34:19,920 EFFECTS FOR LIFESTYLE 2451 01:34:19,920 --> 01:34:20,920 DISRUPTIONS, NOT GOING TO WORK 2452 01:34:20,920 --> 01:34:23,080 OR SCHOOL, ECONOMIC STRESSOR, 2453 01:34:23,080 --> 01:34:26,080 THINGS LIKE LOSS OF JOB OR 2454 01:34:26,080 --> 01:34:27,280 EDUCATION, FINANCIAL ADVERSITY, 2455 01:34:27,280 --> 01:34:29,600 AND SO ON. SO THESE KINDS OF 2456 01:34:29,600 --> 01:34:30,800 DISRUPTIONS TO DAILY LIFE SEEM 2457 01:34:30,800 --> 01:34:33,840 TO BE HAVING A BIGGER IMPACT ON 2458 01:34:33,840 --> 01:34:35,760 PSYCHOPATHOLOGY DURING THE 2459 01:34:35,760 --> 01:34:37,080 PANDEMIC. THAN EVEN RISK OF 2460 01:34:37,080 --> 01:34:38,880 ONE'S SAFETY OR HEALTH. WHAT WE 2461 01:34:38,880 --> 01:34:40,280 SEE IN KIDS IS REALLY 2462 01:34:40,280 --> 01:34:41,640 INTERESTING SO WE USED A 2463 01:34:41,640 --> 01:34:42,800 SLIGHTLY DIFFERENT SET OF 2464 01:34:42,800 --> 01:34:44,680 MEASURES HERE IN THE STUDY I 2465 01:34:44,680 --> 01:34:47,160 SHOWED YO YOU. BUT FAR AND AWAY, 2466 01:34:47,160 --> 01:34:49,200 THE TYPES OF STRESSORS IN OUR 2467 01:34:49,200 --> 01:34:50,880 DATA THAT HAVE BIGGEST IMPACT ON 2468 01:34:50,880 --> 01:34:54,120 INCREASES IN PSYCHOPATHOLOGY 2469 01:34:54,120 --> 01:34:54,840 DURING THE PANDEMIC WERE SOCIAL 2470 01:34:54,840 --> 01:34:57,560 STRESSORS. THINGS LIKE BEING 2471 01:34:57,560 --> 01:34:58,720 ISOLATED, NOT BEING ABLE TO 2472 01:34:58,720 --> 01:35:01,400 INTERACT WITH PEERS, HAVING 2473 01:35:01,400 --> 01:35:02,720 ONGOING CONFLICT WITH SOMEONE IN 2474 01:35:02,720 --> 01:35:04,320 YOUR HOUSE, WE SEE FOR BOTH 2475 01:35:04,320 --> 01:35:06,000 INTERNALIZING AND EXTERNALIZING 2476 01:35:06,000 --> 01:35:09,400 SYMPTOMS THESE STRESSORS HAD A 2477 01:35:09,400 --> 01:35:10,080 DISPROPORTIONATE AFFECT SO 2478 01:35:10,080 --> 01:35:11,200 SOMEBODY I DON'T RECOGNIZE THE 2479 01:35:11,200 --> 01:35:12,120 VOICE BUT SOMEBODY SAID NOT 2480 01:35:12,120 --> 01:35:13,320 BEING ABLE TO GO TO SCHOOL, 2481 01:35:13,320 --> 01:35:15,160 SCHOOL RELATED STRESSOR, THAT 2482 01:35:15,160 --> 01:35:17,240 WAS THE SECOND CATEGORY THAT HAD 2483 01:35:17,240 --> 01:35:18,200 A PARTICULAR LARGE EFFECT AND 2484 01:35:18,200 --> 01:35:20,600 FOR EXTERNALIZING PROBLEMS THIS 2485 01:35:20,600 --> 01:35:22,320 EFFECT IS VIRTUALLY THE SAME AS 2486 01:35:22,320 --> 01:35:23,760 IMPACT OF SOCIAL STRESSORS SO AT 2487 01:35:23,760 --> 01:35:26,640 LEAST IN OUR DATA FOR KIDS, 2488 01:35:26,640 --> 01:35:28,320 THESE SOCIAL SCHOOL RELATED 2489 01:35:28,320 --> 01:35:29,640 STRESSORS ARE THE SPECIFIC TYPES 2490 01:35:29,640 --> 01:35:31,480 OF STRESS THAT ARE DRIVING 2491 01:35:31,480 --> 01:35:32,920 INCREASES IN PSYCHOPATHOLOGY 2492 01:35:32,920 --> 01:35:37,440 MORE THAN OTHERS. SO A FINAL 2493 01:35:37,440 --> 01:35:40,720 MODEL FOCUSES ON THE 2494 01:35:40,720 --> 01:35:43,040 ENVIRONMENTAL COMPONENT OF 2495 01:35:43,040 --> 01:35:44,400 STRESS, STRESS SENSITIZATION. 2496 01:35:44,400 --> 01:35:46,040 THE IDEA IS THIS LINK BETWEEN 2497 01:35:46,040 --> 01:35:48,040 STRESS AND PSYCHOPATHOLOGY IS 2498 01:35:48,040 --> 01:35:49,680 MAGNIFIED OR STRONGER IN PEOPLE 2499 01:35:49,680 --> 01:35:52,760 WHO HAVE A HISTORY OF EARLY LIFE 2500 01:35:52,760 --> 01:35:54,360 ADVERSITY OR EARLY LIFE TRAUMA, 2501 01:35:54,360 --> 01:35:57,080 TO SHOW YOU EXAMPLE OF THIS IN 2502 01:35:57,080 --> 01:35:57,920 DATA REFLECTED BEFORE THE 2503 01:35:57,920 --> 01:36:00,040 PANDEMIC THIS IS REALLY WELL 2504 01:36:00,040 --> 01:36:02,360 REPLICATED EFFECT, THIS IS AN 2505 01:36:02,360 --> 01:36:03,560 EXAMPLE FROM ADULTS, WHAT YOU 2506 01:36:03,560 --> 01:36:05,680 SEE ON THE X AXIS IS NUMBER OF 2507 01:36:05,680 --> 01:36:07,360 PAST YEAR MAJOR STRESSFUL LIFE 2508 01:36:07,360 --> 01:36:11,000 EVENTS, LOSING A JOB, GETTING A 2509 01:36:11,000 --> 01:36:12,440 DIVORCE, THE Y AXIS IS THE 2510 01:36:12,440 --> 01:36:13,680 LIKELIHOOD YOU HAD DEPRESSION IN 2511 01:36:13,680 --> 01:36:15,000 THE PAST YEAR, AND THEN WHAT YOU 2512 01:36:15,000 --> 01:36:16,760 SEE EACH OF THESE LINES REFLECT 2513 01:36:16,760 --> 01:36:17,840 GROUPS OF PEOPLE WITH DIFFERENT 2514 01:36:17,840 --> 01:36:19,840 LEVELS OF EXPOSURE TO EARLY LIFE 2515 01:36:19,840 --> 01:36:21,480 ADVERSITY. THE BASIC IDEA HERE 2516 01:36:21,480 --> 01:36:23,480 IS THAT THE MAGNITUDE OF THIS 2517 01:36:23,480 --> 01:36:25,480 RELATIONSHIP BETWEEN RECENT 2518 01:36:25,480 --> 01:36:26,840 STRESS AND THE ONSET OF 2519 01:36:26,840 --> 01:36:29,320 PSYCHOPATHOLOGY IS MUCH 2520 01:36:29,320 --> 01:36:30,040 STRONGER, THIS LINE STEEPER IF 2521 01:36:30,040 --> 01:36:32,320 YOU HAVE EXPERIENCED A LOT OF 2522 01:36:32,320 --> 01:36:33,800 ADVERSITY AS A CHILD. STEEPEST 2523 01:36:33,800 --> 01:36:35,960 FOR FOLKS WHO HAD THREE O MORE 2524 01:36:35,960 --> 01:36:37,280 ADVERSITY, A LITTLE LESS STEEP 2525 01:36:37,280 --> 01:36:40,800 FOR FOLKS WITH TWO AND THE SORT 2526 01:36:40,800 --> 01:36:42,680 OF MOST SHALLOW FOR FOLKS WHO 2527 01:36:42,680 --> 01:36:44,840 HAVE NOT ENCOUNTERED ADVERSITY. 2528 01:36:44,840 --> 01:36:47,600 SO DURING THE PANDEMIC THERE'S 2529 01:36:47,600 --> 01:36:49,120 BEEN NOT MUCH DATA PUBLISHED YET 2530 01:36:49,120 --> 01:36:50,240 WHETHER THE SAME PATTERN OF 2531 01:36:50,240 --> 01:36:54,120 SENSITIZATION IS TRUE. THIS IS 2532 01:36:54,120 --> 01:36:55,440 DATA FROM (INAUDIBLE) LAB NOT 2533 01:36:55,440 --> 01:36:58,200 SHOWING EXACTLY WHAT I DESCRIBE 2534 01:36:58,200 --> 01:36:59,480 BUD THEY HAVE SHOWN 2535 01:36:59,480 --> 01:37:00,440 UNSURPRISINGLY THAT PEOPLE WHO 2536 01:37:00,440 --> 01:37:01,880 HAD EARLY LIFE ADVERSITY IN 2537 01:37:01,880 --> 01:37:03,720 GENERAL ARE EXPERIENCING HIGHER 2538 01:37:03,720 --> 01:37:05,520 LEVELS OF PERCEIVED STRESS, AND 2539 01:37:05,520 --> 01:37:07,120 HIGHER DEPRESSION SYMPTOMS 2540 01:37:07,120 --> 01:37:10,680 DURING THE PANDEMIC. SOME DATA 2541 01:37:10,680 --> 01:37:12,680 WE HAVEN'T PUBLISHED YET FROM MY 2542 01:37:12,680 --> 01:37:14,760 LAB, I WILL GIVE YOU A PREVIEW, 2543 01:37:14,760 --> 01:37:16,240 SOMEBODY SHOUTED ABUSE, WHAT YOU 2544 01:37:16,240 --> 01:37:19,040 SEE REFLECTED HERE IS THAT, THAT 2545 01:37:19,040 --> 01:37:23,760 THE IMPACT OF THE DAILY PANDEMIC 2546 01:37:23,760 --> 01:37:24,520 RELATED STRESSORS I TALKED ABOUT 2547 01:37:24,520 --> 01:37:27,480 A FEW MINUTES AGO ON SYMPTOMS OF 2548 01:37:27,480 --> 01:37:29,040 INTERNALIZING PROBLEMS, THEY 2549 01:37:29,040 --> 01:37:30,600 HAVE A BIGGER IMPACT FOR KIDS 2550 01:37:30,600 --> 01:37:32,040 WHO HAVE A HISTORY OF EXPOSURE 2551 01:37:32,040 --> 01:37:34,160 TO TRAUMA. OR OTHER KINDS OF 2552 01:37:34,160 --> 01:37:36,920 VIOLENCE. SO THE RELATIONSHIP 2553 01:37:36,920 --> 01:37:38,040 BETWEEN STRESS AND 2554 01:37:38,040 --> 01:37:39,720 PSYCHOPATHOLOGY GETS 2555 01:37:39,720 --> 01:37:40,600 PROGRESSIVELY STEEPER AS 2556 01:37:40,600 --> 01:37:42,280 EXPOSURE TO TRAUMA INCREASES. 2557 01:37:42,280 --> 01:37:44,640 SUCH THAT THE KIDS WERE MOST 2558 01:37:44,640 --> 01:37:45,960 VULNERABLE TO DEVELOPING STRESS 2559 01:37:45,960 --> 01:37:48,800 RELATED PSYCHOPATHOLOGY ARE KIDS 2560 01:37:48,800 --> 01:37:50,200 WHO HAD PRIOR EXPOSURE TO 2561 01:37:50,200 --> 01:37:53,240 TRAUMA, PARTICULARLY IF THAT 2562 01:37:53,240 --> 01:37:55,760 TRAUMA WAS REPEATED OR SEVERE. 2563 01:37:55,760 --> 01:37:59,280 SO I WILL SHIFT NOW FROM THESE 2564 01:37:59,280 --> 01:38:00,400 ENVIRONMENTAL STRESS MODELS WITH 2565 01:38:00,400 --> 01:38:01,680 RELEVANCE FOR THINKING WHO MIGHT 2566 01:38:01,680 --> 01:38:03,000 BE IN NEED OF INTERVENTION TO 2567 01:38:03,000 --> 01:38:05,400 TALKING A LITTLE BIT ABOUT HOW 2568 01:38:05,400 --> 01:38:07,720 MODELS OF RISK AND RESILIENCE 2569 01:38:07,720 --> 01:38:09,920 HELP THINK ABOUT HOW WE MIGHT 2570 01:38:09,920 --> 01:38:11,840 INTERVENE FOR KIDS WHO ARE 2571 01:38:11,840 --> 01:38:13,320 EXPERIENCING STRESS RELATED 2572 01:38:13,320 --> 01:38:14,520 PSYCHOPATHOLOGY. THERE IS KIND 2573 01:38:14,520 --> 01:38:16,680 OF THREE MODELS I'M GOING TO 2574 01:38:16,680 --> 01:38:18,680 DISCUSS HERE. AS WELL. MODELS 2575 01:38:18,680 --> 01:38:21,320 THAT FOCUS ON STRESS APPRAISAL, 2576 01:38:21,320 --> 01:38:23,520 STRESS BUFFERS, PROTECTIVE 2577 01:38:23,520 --> 01:38:25,000 FACTORS THEN STRESS MECHANISMS. 2578 01:38:25,000 --> 01:38:26,600 SO GOING TO TALK FIRST ABOUT 2579 01:38:26,600 --> 01:38:29,000 STRESS APPRAISAL. STRESS PAY 2580 01:38:29,000 --> 01:38:30,440 PRAISAL MODELS FOCUS NOT JUST ON 2581 01:38:30,440 --> 01:38:33,800 THE ROLE OF WHAT HAPPENS IN YOUR 2582 01:38:33,800 --> 01:38:34,960 ENVIRONMENT BUT WAY THESE EVANS 2583 01:38:34,960 --> 01:38:36,760 ARE INTERPRETED, AND APPRAISED 2584 01:38:36,760 --> 01:38:38,440 AND SHAPING HOW YOU RESPOND TO 2585 01:38:38,440 --> 01:38:42,160 THAT STRESSOR. INFLUENTIAL 2586 01:38:42,160 --> 01:38:44,920 MODELS ARGUE THAT WE FEEL STRESS 2587 01:38:44,920 --> 01:38:46,400 AND PERCEIVE DEMANDS OF 2588 01:38:46,400 --> 01:38:47,720 SITUATION TO OUTWEIGH ABILITY TO 2589 01:38:47,720 --> 01:38:48,920 COPE WITH THOSE DEMANDS 2590 01:38:48,920 --> 01:38:52,040 EFFECTIVELY. SO ONE WAY OF 2591 01:38:52,040 --> 01:38:53,680 ASSESSING APPRAISALS IS ASKING 2592 01:38:53,680 --> 01:38:55,360 PEOPLE ABOUT THE DEGREE WHICH 2593 01:38:55,360 --> 01:38:57,080 THEY FEEL EVENTS IN THEIR LIFE 2594 01:38:57,080 --> 01:38:59,000 OVERWHELMING OR OUT OF CONTROL 2595 01:38:59,000 --> 01:39:01,200 IN A GLOBAL WAY. EVEN WHEN A 2596 01:39:01,200 --> 01:39:03,720 SITUATION IS PERCEIVED STRESSFUL 2597 01:39:03,720 --> 01:39:05,400 THERE IS ONGOING APPRAISAL 2598 01:39:05,400 --> 01:39:06,840 PROCESS THAT HAPPENS. WE 2599 01:39:06,840 --> 01:39:09,640 FREQUENTLY REFER TO THIS AS 2600 01:39:09,640 --> 01:39:11,440 COGNITIVE APPRAISAL WHICH ALTERS 2601 01:39:11,440 --> 01:39:12,880 INTERPRETATION OF A SITUATION 2602 01:39:12,880 --> 01:39:14,440 MEANING OVER TIME AND WE KNOW 2603 01:39:14,440 --> 01:39:17,720 THAT ENGAGING IN REAPPRAISAL CAN 2604 01:39:17,720 --> 01:39:19,240 MODULATE CARDIOVASCULAR 2605 01:39:19,240 --> 01:39:20,560 SUBJECTIVE NEURAL AND MENTAL 2606 01:39:20,560 --> 01:39:22,760 HEALTH RESPONSES TO STRESSORS IN 2607 01:39:22,760 --> 01:39:26,560 ADAPTIVE WAYS. SO THE IDEA IS 2608 01:39:26,560 --> 01:39:28,360 PEOPLE WHO ENGAGE IN HIGHER 2609 01:39:28,360 --> 01:39:31,400 LEVEL WAS OF REAPPRAISAL MIGHT 2610 01:39:31,400 --> 01:39:33,160 BE LESS LIKELY IMPACTED IN TERMS 2611 01:39:33,160 --> 01:39:35,240 OF INCREASING MENTAL HEALTH 2612 01:39:35,240 --> 01:39:36,680 PROBLEMS IN RELATION TO PANDEMIC 2613 01:39:36,680 --> 01:39:39,360 RELATED STRESSORS. SO WHAT 2614 01:39:39,360 --> 01:39:41,000 EVIDENCE DO WE HAVE OF THIS 2615 01:39:41,000 --> 01:39:43,400 DURING PANDEMIC? I WILL SHOW YOU 2616 01:39:43,400 --> 01:39:47,560 THE SAME STUDY IAN GOTLIB. IN 2617 01:39:47,560 --> 01:39:50,600 MANY STUDIES WE SEE THE STRESS 2618 01:39:50,600 --> 01:39:51,720 APPRAISALS THAT DEGREE WHICH YOU 2619 01:39:51,720 --> 01:39:53,280 FEEL THINGS ARE OVERWHELMING AND 2620 01:39:53,280 --> 01:39:54,280 YOU DON'T HAVE CONTROL OVER WHAT 2621 01:39:54,280 --> 01:39:55,480 IS GOING ON IN YOUR ENVIRONMENT 2622 01:39:55,480 --> 01:39:57,240 HAS A STRONG RELATIONSHIP TWO 2623 01:39:57,240 --> 01:39:58,760 SYMPTOMS OF PSYCHOPATHOLOGY IN 2624 01:39:58,760 --> 01:40:00,160 THIS STUDY THEY WERE LOOKING AT 2625 01:40:00,160 --> 01:40:02,960 DEPRESSION SYMPTOMS. HERE THEY 2626 01:40:02,960 --> 01:40:04,360 EVEN SHOW THIS HEIGHTEN 2627 01:40:04,360 --> 01:40:06,000 PERCEPTION OF STRESS HELPS TO 2628 01:40:06,000 --> 01:40:07,640 EXPLAIN THE LINK BETWEEN EARLY 2629 01:40:07,640 --> 01:40:08,920 LIFE STRESS AND INCREASING 2630 01:40:08,920 --> 01:40:10,560 SYMPTOMS OF DEPRESSION THAT I 2631 01:40:10,560 --> 01:40:13,880 SHOW YOU A FEW SLIDES BACK. BUT 2632 01:40:13,880 --> 01:40:15,600 THE IDEA THAT SORT OF REAL 2633 01:40:15,600 --> 01:40:17,280 QUESTION IS CAN YOU ALTER THIS 2634 01:40:17,280 --> 01:40:18,280 PROCESS THROUGH THINGS LIKE 2635 01:40:18,280 --> 01:40:19,880 COGNITIVE REAPPRAISAL? THERE IS 2636 01:40:19,880 --> 01:40:23,720 NOT A LOT OF DATA ON THIS IN 2637 01:40:23,720 --> 01:40:24,520 CHILDREN ADOLESCENTS YET DURING 2638 01:40:24,520 --> 01:40:26,000 THE PANDEMIC THERE'S A FEW 2639 01:40:26,000 --> 01:40:28,480 STUDIES BUT IN ADULTS RELATIVELY 2640 01:40:28,480 --> 01:40:30,560 LARGE SAMPLE, YOU CAN SEE LINK 2641 01:40:30,560 --> 01:40:32,360 BETWEEN PERCEPTIONS OF STRESS 2642 01:40:32,360 --> 01:40:35,520 AND SYMPTOMS OF ANXIETY DURING 2643 01:40:35,520 --> 01:40:37,800 EARLY DAYS OF PANDEMIC IS WEAKER 2644 01:40:37,800 --> 01:40:39,400 AND PEOPLE WHO ROUTINELY ENGAGE 2645 01:40:39,400 --> 01:40:41,240 IN COGNITIVE REAPPRAISAL SO IF 2646 01:40:41,240 --> 01:40:42,880 YOU ARE USING THE REAPPRAISAL 2647 01:40:42,880 --> 01:40:43,720 STRATEGY MORE EVEN IF 2648 01:40:43,720 --> 01:40:45,200 EXPERIENCING A LOT OF STRESS IT 2649 01:40:45,200 --> 01:40:46,400 IS LESS LIKELY TO LEAD TO 2650 01:40:46,400 --> 01:40:52,440 SYMPTOMS OF ANXIETY. SO I HAVE 2651 01:40:52,440 --> 01:40:53,480 BEEN TALKING HOW EXPOSURE TO 2652 01:40:53,480 --> 01:40:55,080 STRESS IS A POWERFUL PREDICTOR 2653 01:40:55,080 --> 01:40:57,840 OF PSYCHOPATHOLOGY BUT WE KNOW 2654 01:40:57,840 --> 01:40:59,240 THAT NOT EVERYONE EXPERIENCE 2655 01:40:59,240 --> 01:41:00,520 EVEN HIGH LEVELS OF STRESS IS 2656 01:41:00,520 --> 01:41:02,920 GOING TO DEVELOPMENTAL HEALTH 2657 01:41:02,920 --> 01:41:05,200 PROBLEM. THIS IS TRUE EVEN AFTER 2658 01:41:05,200 --> 01:41:07,120 SERIOUS TRAUMATIC EVENTS LOSS OF 2659 01:41:07,120 --> 01:41:09,320 LOVED ONES NATURAL DISASTERS AND 2660 01:41:09,320 --> 01:41:11,680 ALSO TRUE IN CONTEXT OF THE 2661 01:41:11,680 --> 01:41:14,480 PANDEMIC. PROTECTIVE FACTORS 2662 01:41:14,480 --> 01:41:20,720 THAT BUFFER AGAINST EMERGENCE OF 2663 01:41:20,720 --> 01:41:21,640 PSYCHOPATHOLOGY FOLLOWING STRESS 2664 01:41:21,640 --> 01:41:23,600 AN ADVERSITY HAVE BEEN STUDIED 2665 01:41:23,600 --> 01:41:24,880 EXTENSIVELY, I WILL TALK ABOUT 2666 01:41:24,880 --> 01:41:26,360 WHAT WE HAVE SEEN ABOUT TYPES OF 2667 01:41:26,360 --> 01:41:28,280 STRESS BUFFERS DURING PANDEMIC. 2668 01:41:28,280 --> 01:41:30,040 THE IDEA IS THIS LINK BETWEEN 2669 01:41:30,040 --> 01:41:31,840 STRESS AN PSYCHOPATHOLOGY IS 2670 01:41:31,840 --> 01:41:34,320 WEAKER OR BUFFERED SMALLER, IN 2671 01:41:34,320 --> 01:41:35,960 PEOPLE WHO HAVE THE PRESENCE OF 2672 01:41:35,960 --> 01:41:38,760 SOME KIND OF PROTECTIVE FACTOR. 2673 01:41:38,760 --> 01:41:41,880 WHAT I WILL SAY HERE IS ACTUALLY 2674 01:41:41,880 --> 01:41:43,800 I THINK THE POSITIVE MESSENGER, 2675 01:41:43,800 --> 01:41:46,000 GOOD NEWS ABOUT MENTAL HEALTH 2676 01:41:46,000 --> 01:41:47,480 DURING THE PANDEMIC. IN OUR 2677 01:41:47,480 --> 01:41:49,840 LONGITUDINAL WORK STUDYING KIDS 2678 01:41:49,840 --> 01:41:52,280 IN ADOLESCENCE OVER TIME WE LOOK 2679 01:41:52,280 --> 01:41:53,840 AT FACTORS THAT MIGHT PROTECT 2680 01:41:53,840 --> 01:41:54,880 AGAINST DEVELOPING MENTAL HEALTH 2681 01:41:54,880 --> 01:41:56,560 PROBLEMS DURING THE PANDEMIC. WE 2682 01:41:56,560 --> 01:41:59,520 FOCUSED ON STRESS BUFFERS THAT 2683 01:41:59,520 --> 01:42:02,040 WERE LOW COST, EASILY ACCESSIBLE 2684 01:42:02,040 --> 01:42:02,800 AND DIDN'T REQUIRE ANY 2685 01:42:02,800 --> 01:42:04,000 CONNECTION TO SPECIALIZED 2686 01:42:04,000 --> 01:42:05,280 SERVICES, GIVEN THE CONSTRAINTS 2687 01:42:05,280 --> 01:42:07,000 THAT MANY FAMILIES FACE DURING 2688 01:42:07,000 --> 01:42:08,800 THE EARLY PART OF THE PANDEMIC 2689 01:42:08,800 --> 01:42:10,360 IN PARTICULAR. AND THE POSITIVE 2690 01:42:10,360 --> 01:42:14,400 MESSAGE HERE IS WE FOUND MANY 2691 01:42:14,400 --> 01:42:16,040 SOURCES OF WHAT HAVE IS CALLED 2692 01:42:16,040 --> 01:42:17,600 ORDINARY MAGIC CHARACTERISTICS 2693 01:42:17,600 --> 01:42:19,600 THAT HELP PREVENT ONSET OF 2694 01:42:19,600 --> 01:42:21,240 PSYCHOPATHOLOGY EVEN IN KIDS 2695 01:42:21,240 --> 01:42:22,360 EXPERIENCING HIGH LEVELS OF 2696 01:42:22,360 --> 01:42:23,400 PANDEMIC RELATED STRESS. SO YOU 2697 01:42:23,400 --> 01:42:25,640 CAN SEE THESE LISTED HER HERE. I 2698 01:42:25,640 --> 01:42:27,760 WILL WALK THROUGH THREE 2699 01:42:27,760 --> 01:42:28,640 EXAMPLES. SOME FROM DATA IN MY 2700 01:42:28,640 --> 01:42:31,760 LAB AND SOME FROM DATA IN OTHER 2701 01:42:31,760 --> 01:42:34,240 LABS. UNSURPRISINGLY THE FIRST 2702 01:42:34,240 --> 01:42:36,760 IS SOCIAL SUPPORT. THIS IS 2703 01:42:36,760 --> 01:42:37,920 UNSURPRISING BECAUSE WE HAVE 2704 01:42:37,920 --> 01:42:39,200 KNOWN FOR DECADES THAT OF ALL OF 2705 01:42:39,200 --> 01:42:41,000 THE POTENTIAL PROTECTIVE FACTORS 2706 01:42:41,000 --> 01:42:42,080 THAT HELP TO BUFFER AGAINST 2707 01:42:42,080 --> 01:42:44,200 STRESS RELATED PSYCHOPATHOLOGY, 2708 01:42:44,200 --> 01:42:47,080 SOCIAL SUPPORT IS AMONG THE MOST 2709 01:42:47,080 --> 01:42:48,720 POWERFUL. THIS WAS A CHALLENGING 2710 01:42:48,720 --> 01:42:50,200 DURING THE PANDEMIC BECAUSE 2711 01:42:50,200 --> 01:42:52,000 ACCESS TO SOCIAL SUPPORT WAS SO 2712 01:42:52,000 --> 01:42:53,400 MUCH MORE DIFFICULT FOR MANY 2713 01:42:53,400 --> 01:42:55,000 PEOPLE THAN IT WAS PRIOR TO THE 2714 01:42:55,000 --> 01:42:57,680 PANDEMIC BUT WHAT YOU SEE IN OUR 2715 01:42:57,680 --> 01:42:58,480 DATA DURING THE EARLY PHASE OF 2716 01:42:58,480 --> 01:43:00,360 PANDEMIC IS POWERFUL LINK 2717 01:43:00,360 --> 01:43:01,360 BETWEEN STRESS AND 2718 01:43:01,360 --> 01:43:02,040 PSYCHOPATHOLOGY FOR 2719 01:43:02,040 --> 01:43:03,440 INTERNALIZING PROBLEMS IS 2720 01:43:03,440 --> 01:43:05,160 ESSENTIALLY ABSENT IN CHILDREN 2721 01:43:05,160 --> 01:43:06,960 WHO REPORTED THAT THEY FELT HIGH 2722 01:43:06,960 --> 01:43:09,960 LEVELS OF SOCIAL SUPPORT FROM 2723 01:43:09,960 --> 01:43:13,880 THEIR PEERS. THIS IS PEERS 2724 01:43:13,880 --> 01:43:14,720 SPECIFICALLY. I WANT TO MENTION 2725 01:43:14,720 --> 01:43:16,960 THIS IS TRUE NOT JUST IN KIDS 2726 01:43:16,960 --> 01:43:18,360 AND ADOLESCENTS BUT ALSO ADULTS. 2727 01:43:18,360 --> 01:43:20,160 THIS IS A STUDY THAT I THINK IS 2728 01:43:20,160 --> 01:43:21,920 PARTICULARLY RELEVANT TO THE 2729 01:43:21,920 --> 01:43:23,040 EVENTS OF THE PAST COUPLE OF 2730 01:43:23,040 --> 01:43:26,640 YEARS, THIS WAS A SAMPLE OF 2731 01:43:26,640 --> 01:43:27,760 ASIAN AMERICANS AT THE BEGINNING 2732 01:43:27,760 --> 01:43:29,000 OF THE PANDEMIC. WHAT THEY FOUND 2733 01:43:29,000 --> 01:43:31,400 IS SIMILARLY HIGH LEVELS OF 2734 01:43:31,400 --> 01:43:32,640 SOCIAL SUPPORT BUFFERED AGAINST 2735 01:43:32,640 --> 01:43:35,160 EXPERIENCES OF DISCRIMINATION 2736 01:43:35,160 --> 01:43:36,400 AND MICROAGGRESSIONS THAT P HAD 2737 01:43:36,400 --> 01:43:37,880 DURING THE EARLY PHASE OF THE 2738 01:43:37,880 --> 01:43:39,720 PANDEMIC SUCH THAT THE SORT OF 2739 01:43:39,720 --> 01:43:41,840 STRONG LINK BETWEEN 2740 01:43:41,840 --> 01:43:42,680 DISCRIMINATION AND PHYSICAL 2741 01:43:42,680 --> 01:43:46,040 SYMPTOMS OF ANXIETY, SOMATIC 2742 01:43:46,040 --> 01:43:47,040 SYMPTOMS WAS ABOUT SENTENCE IN 2743 01:43:47,040 --> 01:43:48,560 PEOPLE WHO REPORTED FEELING HIGH 2744 01:43:48,560 --> 01:43:50,120 LEVELS OF EMOTIONAL SUPPORT FROM 2745 01:43:50,120 --> 01:43:51,240 THEIR FAMILY AND FROM THEIR 2746 01:43:51,240 --> 01:43:55,160 FRIENDS. A SECOND PROTECTIVE 2747 01:43:55,160 --> 01:43:58,200 FACTOR, I THINK THIS IS SORT OF 2748 01:43:58,200 --> 01:43:58,880 SCIENCE YOU CAN USE WHEN YOU 2749 01:43:58,880 --> 01:44:00,920 THINK ABOUT YOUR OWN LIFE AND 2750 01:44:00,920 --> 01:44:04,040 YOUR FAMILY, IS THAT KIDS WHO 2751 01:44:04,040 --> 01:44:06,680 ENGAGE IN LOWER LEVELS OF 2752 01:44:06,680 --> 01:44:08,240 PASSIVE SCREEN TIME, WHEN I SAY 2753 01:44:08,240 --> 01:44:09,920 PASSIVE SCREEN TIME WHAT I MEAN 2754 01:44:09,920 --> 01:44:11,760 IS SORT OF SCROLLING THROUGH 2755 01:44:11,760 --> 01:44:13,240 YOUTUBE VIDEOS LOOKING AT SOCIAL 2756 01:44:13,240 --> 01:44:15,480 MEDIA, WE ARE NOT TALKING ABOUT 2757 01:44:15,480 --> 01:44:17,320 ENGAGING IN SCREEN TIME FOR 2758 01:44:17,320 --> 01:44:18,520 SCHOOL OR SOCIAL ENGAGEMENT BUT 2759 01:44:18,520 --> 01:44:20,840 THAT MORE SORT OF PASSIVE INTAKE 2760 01:44:20,840 --> 01:44:23,080 OF CONTENT, WHAT WAY SAW IS THIS 2761 01:44:23,080 --> 01:44:24,960 LINK BETWEEN STRESS AN 2762 01:44:24,960 --> 01:44:26,480 PSYCHOPATHOLOGY FOR BOTH 2763 01:44:26,480 --> 01:44:28,400 INTERNALIZING AND EXTERNALIZING 2764 01:44:28,400 --> 01:44:29,440 PROBLEMS DURING THE EARLY PHASE 2765 01:44:29,440 --> 01:44:31,000 OF PANDEMIC WAS SUBSTANTIALLY 2766 01:44:31,000 --> 01:44:32,800 SMALLER IN KIDS WHO HAD LESS 2767 01:44:32,800 --> 01:44:34,920 EXPOSURE TO SCREEN TIME. I KNOW 2768 01:44:34,920 --> 01:44:37,080 JOSH WAS TALKING ABOUT SOME 2769 01:44:37,080 --> 01:44:38,120 INITIATIVES ABOUT SOCIAL MEDIA 2770 01:44:38,120 --> 01:44:40,400 AND MENTAL HEALTH, THESE DATA 2771 01:44:40,400 --> 01:44:42,120 DON'T SPEAK TO THAT DIRECTLY BUT 2772 01:44:42,120 --> 01:44:44,040 THEY DO SUGGEST THAT LIMITING 2773 01:44:44,040 --> 01:44:46,240 THE AMOUNT OF SCREEN TIME KIDS 2774 01:44:46,240 --> 01:44:48,800 HAVE THAT ISN'T FOCUS ON SCHOOL 2775 01:44:48,800 --> 01:44:50,520 OR SOCIAL ENGAGEMENTED MIGHT BE 2776 01:44:50,520 --> 01:44:53,080 PROTECTIVE AGAINST STRESSFUL 2777 01:44:53,080 --> 01:44:53,680 PSYCHOPATHOLOGY. THIS IS NOT 2778 01:44:53,680 --> 01:44:56,960 DATA FROM MY LAB, THIS IS FROM 2779 01:44:56,960 --> 01:44:58,400 (INAUDIBLE) LAB BUT WE REPLICATE 2780 01:44:58,400 --> 01:45:00,000 THIS THIS IN OUR DATA, FAMILY 2781 01:45:00,000 --> 01:45:01,960 WHOSE ARE ABLE TO MAINTAIN A 2782 01:45:01,960 --> 01:45:03,760 STRUCTURED DAILY ROUTINE, EVEN 2783 01:45:03,760 --> 01:45:05,400 IF THAT ROUTINE WAS DIFFERENT 2784 01:45:05,400 --> 01:45:06,360 THAN THE ROUTINE OBVIOUSLY WE 2785 01:45:06,360 --> 01:45:08,760 HAD PRIOR TO THE PACK, HAVING 2786 01:45:08,760 --> 01:45:11,680 THAT DAILY STRUCTURE SEEMS TO 2787 01:45:11,680 --> 01:45:13,120 PROTECT IN THEIR DATA AGAINST 2788 01:45:13,120 --> 01:45:14,280 INTERNALIZING PROBLEMS IN THE 2789 01:45:14,280 --> 01:45:15,800 FACE OF STRESS AND OUR DATA WE 2790 01:45:15,800 --> 01:45:17,680 SAW THIS EFFECT MORE STRONGLY 2791 01:45:17,680 --> 01:45:19,280 FOR EXTERNALIZING PROBLEMS BUT 2792 01:45:19,280 --> 01:45:21,800 BASICALLY THE SAME PATTERN. THAT 2793 01:45:21,800 --> 01:45:23,560 FOR KIDS WHO HAD MORE STRUCTURE 2794 01:45:23,560 --> 01:45:27,320 IN THEIR DAILY ROUTINES WERE 2795 01:45:27,320 --> 01:45:29,120 LESS VULNERABLE TO DEVELOPING 2796 01:45:29,120 --> 01:45:30,440 STRESS RELATED PSYCHOPATHOLOGY. 2797 01:45:30,440 --> 01:45:33,160 SO FINALLY, I WILL TOUCH BRIEFLY 2798 01:45:33,160 --> 01:45:35,120 ON STRESS MECHANISMS. WHICH IN 2799 01:45:35,120 --> 01:45:36,600 SOME WAYS IF WE ARE THINKING 2800 01:45:36,600 --> 01:45:37,760 INTERVENTIONS THIS IS WHAT WE 2801 01:45:37,760 --> 01:45:39,720 WANT TO BE THINKING ABOUT. SO WE 2802 01:45:39,720 --> 01:45:41,680 KNOW THAT EXPOSURE TO STRESS 2803 01:45:41,680 --> 01:45:42,600 INCREASE RISK FOR 2804 01:45:42,600 --> 01:45:43,440 PSYCHOPATHOLOGY THROUGH A 2805 01:45:43,440 --> 01:45:44,840 VARIETY OF INTERVENING PATHWAYS 2806 01:45:44,840 --> 01:45:48,040 AND MECHANISMS. PATHWAYS THAT 2807 01:45:48,040 --> 01:45:49,560 HAVE GARNERED EMPIRICAL SUPPORT 2808 01:45:49,560 --> 01:45:51,680 INCLUDING SLEEP AND CHANGES IN 2809 01:45:51,680 --> 01:45:52,400 EMOTIONAL RELATION, CHANGES IN 2810 01:45:52,400 --> 01:45:56,080 THE WORD PROCESSING, SUCH THAT 2811 01:45:56,080 --> 01:45:57,880 STRESS LEADS TO CHANGES IN THESE 2812 01:45:57,880 --> 01:45:59,400 MECHANISMS WHICH IN TURN PREDICT 2813 01:45:59,400 --> 01:46:01,960 THE EMERGENCE OF PSYCHOPATHOLOGY 2814 01:46:01,960 --> 01:46:04,560 SYMPTOMS. WHAT I WILL SAY IS 2815 01:46:04,560 --> 01:46:08,440 THAT BECAUSE OF THE NATURE OF 2816 01:46:08,440 --> 01:46:09,080 THE PANDEMIC MOST RESEARCH HAD 2817 01:46:09,080 --> 01:46:10,160 TO BE CONDUCTED REMOTELY DURING 2818 01:46:10,160 --> 01:46:11,960 THE EARLY PHASE OF THE PANDEMIC, 2819 01:46:11,960 --> 01:46:13,640 THE WORK ON MECHANISMS HERE IS 2820 01:46:13,640 --> 01:46:15,760 LESS RICH THAN SOME OF THE OTHER 2821 01:46:15,760 --> 01:46:17,040 AREAS I DESCRIBE MOSTLY BECAUSE 2822 01:46:17,040 --> 01:46:18,280 IT IS DIFFICULT TO STUDY A LOT 2823 01:46:18,280 --> 01:46:20,840 OF MECHANISMS USING SELF-REPORT 2824 01:46:20,840 --> 01:46:22,280 AND ONLINE REPORTING TOOLS THAT 2825 01:46:22,280 --> 01:46:24,000 WERE AVAILABLE TO RESEARCHERS AT 2826 01:46:24,000 --> 01:46:26,000 THE BEGINNING OF THE PANDEMIC SO 2827 01:46:26,000 --> 01:46:27,280 I WILL APPLY ONE EXAMPLE OF 2828 01:46:27,280 --> 01:46:28,480 STRESS MECHANISMS FROM MY LAB 2829 01:46:28,480 --> 01:46:29,840 AND TALK A LITTLE BIT ABOUT TWO 2830 01:46:29,840 --> 01:46:32,080 RELEVANT PATHWAYS USING DATA 2831 01:46:32,080 --> 01:46:33,480 THAT WERE CHECKED PRIOR TO THE 2832 01:46:33,480 --> 01:46:36,480 PANDEMIC. SO -- COLLECTED PRIOR 2833 01:46:36,480 --> 01:46:37,920 TO THE PANDEMIC. IS FIRST IS 2834 01:46:37,920 --> 01:46:41,600 CHANGES IN EMOTION REGULATION. I 2835 01:46:41,600 --> 01:46:42,760 WILL PROVIDE A SIMPLE EXAMPLE. 2836 01:46:42,760 --> 01:46:44,200 RUMINATION IS AN EMOTION 2837 01:46:44,200 --> 01:46:46,400 REGULATION STRATEGY THAT 2838 01:46:46,400 --> 01:46:47,720 INVOLVES PASSIVELY REPETITIVELY 2839 01:46:47,720 --> 01:46:48,920 THINKING ABOUT CAUSES AN 2840 01:46:48,920 --> 01:46:50,440 CONSEQUENCES OF NEGATIVE MOOD 2841 01:46:50,440 --> 01:46:52,360 WITHOUT MOVING INTO ACTIVE 2842 01:46:52,360 --> 01:46:54,240 PROBLEM SOLVING. MUCH DATA 2843 01:46:54,240 --> 01:46:55,680 COLLECTED PRIOR TO THE PANDEMIC 2844 01:46:55,680 --> 01:46:57,200 SUGGESTS THAT PEOPLE RUMINATE 2845 01:46:57,200 --> 01:46:58,480 MORE WHEN EXPERIENCING LOTS OF 2846 01:46:58,480 --> 01:47:00,680 STRESS. AND THIS IS A MECHANISM 2847 01:47:00,680 --> 01:47:01,920 THAT LINKS STRESS WITH 2848 01:47:01,920 --> 01:47:03,840 PSYCHOPATHOLOGY, WE SEE THAT 2849 01:47:03,840 --> 01:47:04,840 MIRED IN OUR DATA DURING THE 2850 01:47:04,840 --> 01:47:06,240 PANDEMPANDEMIC. SO FIRST WE SAWS 2851 01:47:06,240 --> 01:47:07,720 WITH HIGHER NUMBER OF THESE 2852 01:47:07,720 --> 01:47:09,280 PANDEMIC RELATED STRESSORS WERE 2853 01:47:09,280 --> 01:47:12,040 MORE LIKELY TO HAVE INCREASES IN 2854 01:47:12,040 --> 01:47:12,800 RUMINATION RELATIVE TO BEFORE 2855 01:47:12,800 --> 01:47:15,840 THE PANDEMIC. NOT SURPRISINGLY 2856 01:47:15,840 --> 01:47:16,600 RUMINATION PREDICTED HIGHER 2857 01:47:16,600 --> 01:47:17,400 LEVELS OF INTERNALIZING 2858 01:47:17,400 --> 01:47:19,760 SYMPTOMS. THIS IS NOT 2859 01:47:19,760 --> 01:47:22,520 SURPRISING WE KNOW THAT AND IT 2860 01:47:22,520 --> 01:47:23,240 HELPS TO EXPLAIN, DIDN'T 2861 01:47:23,240 --> 01:47:25,320 COMPLETELY BUT HELPED TO EXPLAIN 2862 01:47:25,320 --> 01:47:27,360 OR MEDIATE THE LINK BETWEEN 2863 01:47:27,360 --> 01:47:29,200 PANDEMIC RELATED STRESSORS AN 2864 01:47:29,200 --> 01:47:30,880 INTERNALIZING SYMPTOMS. SO I 2865 01:47:30,880 --> 01:47:32,640 WILL HIGHLIGHT TWO OTHER 2866 01:47:32,640 --> 01:47:35,000 RELEVANT PATHWAYS THAT MIGHT 2867 01:47:35,000 --> 01:47:36,040 HELP TO EXPLAIN THE LINK BETWEEN 2868 01:47:36,040 --> 01:47:37,760 PANDEMIC RELATED STRESSORS AND 2869 01:47:37,760 --> 01:47:38,480 PSYCHOPATHOLOGY WE ARE 2870 01:47:38,480 --> 01:47:40,240 CHALLENGING TO STUDY DURING THE 2871 01:47:40,240 --> 01:47:41,520 PANDEMIC ESPECIALLY EARLY PHASE. 2872 01:47:41,520 --> 01:47:42,840 SO I WILL SHOW YOU DATA 2873 01:47:42,840 --> 01:47:44,120 COLLECTED JUST BEFORE THE 2874 01:47:44,120 --> 01:47:45,280 PANDEMIC STARTED THAT HAS 2875 01:47:45,280 --> 01:47:48,080 RELEVANCE TO EXPERIENCES WE HAVE 2876 01:47:48,080 --> 01:47:49,200 ALL HAD THE PAST COUPLE OF 2877 01:47:49,200 --> 01:47:52,000 YEARS. FIRST INVOLVES 2878 01:47:52,000 --> 01:47:53,040 EXPERIENTIAL DIVERSITY. I WILL 2879 01:47:53,040 --> 01:47:57,760 SHOW YOU DATA FROM AARON HULLER 2880 01:47:57,760 --> 01:48:00,120 UNIVERSITY OF MIAMI AND KATE 2881 01:48:00,120 --> 01:48:02,640 HEARTILY, NYU. EXPERIENTIAL 2882 01:48:02,640 --> 01:48:03,400 DIVERSITY REFLECTS VARIABILITY 2883 01:48:03,400 --> 01:48:05,160 IN OUR ENVIRONMENTAL CONTEXTS 2884 01:48:05,160 --> 01:48:07,760 OVER TIME. SO WHAT I'M SHOWING 2885 01:48:07,760 --> 01:48:09,160 HERE EXAMPLES FROM ONE 2886 01:48:09,160 --> 01:48:10,560 PARTICIPANT IN THE STUDY ON TWO 2887 01:48:10,560 --> 01:48:11,880 SEPARATE DAYS. ON THE LEFT YOU 2888 01:48:11,880 --> 01:48:14,240 SEE A DATA CHARACTERIZED BY LOW 2889 01:48:14,240 --> 01:48:16,480 EXPERIENTIAL DIVERSITY, THE 2890 01:48:16,480 --> 01:48:18,160 LARGER BUBBLE MORE TIME SPENT IN 2891 01:48:18,160 --> 01:48:20,440 PLACE. THIS IS DATA SCRAPED FROM 2892 01:48:20,440 --> 01:48:22,400 CELL PHONES ON GPS LOCATION. YOU 2893 01:48:22,400 --> 01:48:24,080 CAN SEE THIS KID SPENT MOST TIME 2894 01:48:24,080 --> 01:48:25,800 HERE AT HOME, THEY WENT TO ONE 2895 01:48:25,800 --> 01:48:27,720 OTHER LOCATION, CAME BACK. IN 2896 01:48:27,720 --> 01:48:29,520 CONTRAST THIS IS A DAY 2897 01:48:29,520 --> 01:48:32,640 CHARACTERIZED BY HIGH 2898 01:48:32,640 --> 01:48:34,240 EXPERIENTIAL DIVERSITY, THIS 2899 01:48:34,240 --> 01:48:35,240 CHILDS TRAVERSE A LOT OF 2900 01:48:35,240 --> 01:48:36,880 LOCATIONS, SPENT TIME IN 2901 01:48:36,880 --> 01:48:40,840 DIFFERENT PLACES. SAME DATA FROM 2902 01:48:40,840 --> 01:48:42,080 THAT WAS NEW YORK THIS IS MIAMI. 2903 01:48:42,080 --> 01:48:43,720 SAME EXAMPLE, A DAY 2904 01:48:43,720 --> 01:48:44,800 CHARACTERIZED BY LOW 2905 01:48:44,800 --> 01:48:46,560 EXPERIENTIAL DIVERSITY, A DAY 2906 01:48:46,560 --> 01:48:47,520 CHARACTERIZED BY HIGH 2907 01:48:47,520 --> 01:48:48,920 EXPERIENTIAL DIVERSITY. WHAT I 2908 01:48:48,920 --> 01:48:50,320 WILL SAY IS WE THINK ABOUT LIFE 2909 01:48:50,320 --> 01:48:51,600 DURING THE PANDEMIC IT LOOKED 2910 01:48:51,600 --> 01:48:53,360 MORE LIKE THIS. RIGHT? SO OUR 2911 01:48:53,360 --> 01:48:55,440 LIVES PARTICULARLY IN EARLY 2912 01:48:55,440 --> 01:48:56,800 PHASE OF THE PANDEMIC WERE 2913 01:48:56,800 --> 01:48:58,800 EXTREMELY CONSTRAINTED IN TERMS 2914 01:48:58,800 --> 01:49:00,120 OF DIVERSITY OF ENVIRONMENTAL 2915 01:49:00,120 --> 01:49:01,760 VARIABILITY AND NOVELTY AND 2916 01:49:01,760 --> 01:49:03,760 CONTEXT THAT WE WERE 2917 01:49:03,760 --> 01:49:05,640 EXPERIENCING OVER TIME. WHAT 2918 01:49:05,640 --> 01:49:07,760 THIS STUDY SHOWED IS THAT -- 2919 01:49:07,760 --> 01:49:09,360 THEY QUANTIFY THIRD DEGREE WITH 2920 01:49:09,360 --> 01:49:12,680 MEASURE CALLED ROAMING ENTROPY, 2921 01:49:12,680 --> 01:49:13,960 HAPPY TO TALK ABOUT THAT MORE, 2922 01:49:13,960 --> 01:49:15,480 HIGHER LEVELS MEANS MORE 2923 01:49:15,480 --> 01:49:16,360 DIVERSITY IN CONTEXT AND TIME 2924 01:49:16,360 --> 01:49:17,960 YOU SPENT IN DIFFERENT PLACES. 2925 01:49:17,960 --> 01:49:19,560 WHAT THEY SAW IS THAT THE MORE 2926 01:49:19,560 --> 01:49:20,840 DIVERSITY YOU HAD IN THOSE 2927 01:49:20,840 --> 01:49:22,440 EXPERIENCES, THE HIGHER YOUR 2928 01:49:22,440 --> 01:49:23,840 POSITIVE AFFECT WAS ON THOSE 2929 01:49:23,840 --> 01:49:26,360 DAYS RELATIVE TO OTHER DAYS. 2930 01:49:26,360 --> 01:49:28,480 THE IDEA THAT WHEN OUR CONTACTS 2931 01:49:28,480 --> 01:49:29,760 ARE CONSTRAINED AND NOT 2932 01:49:29,760 --> 01:49:32,960 EXPERIENCING A LOT OF NOVELTY OR 2933 01:49:32,960 --> 01:49:34,680 VARIABILITY IN ENVIRONMENTAL 2934 01:49:34,680 --> 01:49:36,560 CONTEXT, THIS REDUCES POSITIVE 2935 01:49:36,560 --> 01:49:38,000 AFFECT AND WHEN WE JUST REFLECT 2936 01:49:38,000 --> 01:49:39,880 ON EXPERIENCES THE PAST COUPLE 2937 01:49:39,880 --> 01:49:41,200 OF YEARS PROBABLY REIGNS TRUE 2938 01:49:41,200 --> 01:49:43,000 FOR MANY OF US, THAT SORT OF 2939 01:49:43,000 --> 01:49:45,080 LACK OF NOVELTY AND DIVERSITY 2940 01:49:45,080 --> 01:49:48,520 AND ENVIRONMENTAL VARIABILITY IS 2941 01:49:48,520 --> 01:49:49,800 SOMETHING THAT DRAINED POSITIVE 2942 01:49:49,800 --> 01:49:51,720 AFFECT WE KNOW HAS HUGE IMPACT 2943 01:49:51,720 --> 01:49:52,800 ON MENTAL HEALTH PROBLEMS 2944 01:49:52,800 --> 01:49:56,120 PARTICULARLY DEPRESSION. SO A 2945 01:49:56,120 --> 01:49:58,400 SECOND POTENTIAL MECHANISM, 2946 01:49:58,400 --> 01:50:00,440 OBVIOUSLY RELEVANT TO STRESS, 2947 01:50:00,440 --> 01:50:02,440 THOSE THINGS OPENED UP OUR 2948 01:50:02,440 --> 01:50:05,120 CONTEXT VERSUS STARTED TO CHANGE 2949 01:50:05,120 --> 01:50:07,120 MORE, BUT IDEA FOLKS MORE 2950 01:50:07,120 --> 01:50:08,000 FEARFUL ABOUT GETTING COVID WHO 2951 01:50:08,000 --> 01:50:10,520 ARE EXPERIENCING MORE STRESSORS 2952 01:50:10,520 --> 01:50:12,200 MAYBE ARE LESS LIKELY TO BE 2953 01:50:12,200 --> 01:50:14,680 REENGAGING WITH NUMBER OF 2954 01:50:14,680 --> 01:50:16,000 CONTEXT THEY DID PRIOR TO 2955 01:50:16,000 --> 01:50:18,120 PANDEMIC SO THIS IS A 2956 01:50:18,120 --> 01:50:18,720 POTENTIALLY INTERESTING TARGET 2957 01:50:18,720 --> 01:50:20,080 TO THINK ABOUT IN TERMS OF 2958 01:50:20,080 --> 01:50:22,400 INTERVENTION. THEN FINALLY, I 2959 01:50:22,400 --> 01:50:24,720 HAVE TIME, I WILL TALK A LITTLE 2960 01:50:24,720 --> 01:50:26,280 BIT ABOUT CHANGES IN BRAIN 2961 01:50:26,280 --> 01:50:28,360 FUNCTION. THIS IS PILOT DATA 2962 01:50:28,360 --> 01:50:30,600 FROM MY LAB THAT SERVED AS BASIS 2963 01:50:30,600 --> 01:50:33,800 FOR MY CURRENT R 37 FROM NIMH I 2964 01:50:33,800 --> 01:50:35,440 SHOULD BE PROBABLY THANKING 2965 01:50:35,440 --> 01:50:37,080 EVERYBODY IN THIS ROOM FOR WHICH 2966 01:50:37,080 --> 01:50:38,920 FOCUSES ON EMOTIONAL AND 2967 01:50:38,920 --> 01:50:41,320 COGNITIVE AND NEURAL MECHANISMS 2968 01:50:41,320 --> 01:50:42,680 THAT LINK STRESSFUL 2969 01:50:42,680 --> 01:50:44,640 PSYCHOPATHOLOGY DURING THE 2970 01:50:44,640 --> 01:50:45,280 ADOLESCENCE. 2971 01:50:45,280 --> 01:50:46,840 WHAT I WILL HIGHLIGHT IS 2972 01:50:46,840 --> 01:50:49,200 EXISTING WORK ON THESE 2973 01:50:49,200 --> 01:50:51,120 MECHANISMS PARTICULARLY WITH 2974 01:50:51,120 --> 01:50:53,480 BRAIN FUNCTION, HAS LARGELY 2975 01:50:53,480 --> 01:50:55,080 RELIED ON BETWEEN PERSON CROSS 2976 01:50:55,080 --> 01:50:56,720 SECTIONAL STUDIES. THE WAY 2977 01:50:56,720 --> 01:50:58,200 STUDIES HAVE TRADITIONALLY 2978 01:50:58,200 --> 01:51:00,160 WORKED YOU RECRUIT A GROUP OF 2979 01:51:00,160 --> 01:51:01,440 KIDS WITH HIGH LEVEL STRESS, 2980 01:51:01,440 --> 01:51:03,080 ANOTHER WHO HAS NOT EXPERIENCED 2981 01:51:03,080 --> 01:51:05,240 THOSE STRESSORS AND THEN YOU 2982 01:51:05,240 --> 01:51:06,560 COMPARE THEIR BRAIN RESPONSE TO 2983 01:51:06,560 --> 01:51:08,680 SOME TYPE OF TASK. YOU ASSUME IF 2984 01:51:08,680 --> 01:51:09,960 YOU SEE A DIFFERENCE, THAT 2985 01:51:09,960 --> 01:51:11,240 DIFFERENCE IS ATTRIBUTABLE TO 2986 01:51:11,240 --> 01:51:12,560 THE DIFFERENCES IN STRESS THAT 2987 01:51:12,560 --> 01:51:13,440 THESE TWO GROUPS OF CHILDREN 2988 01:51:13,440 --> 01:51:15,760 EXPERIENCE. WE KNOW WILL IS A 2989 01:51:15,760 --> 01:51:17,520 LOT OF CHALLENGES WITH THIS KIND 2990 01:51:17,520 --> 01:51:20,720 OF INTERPRETATION. BECAUSE THESE 2991 01:51:20,720 --> 01:51:22,680 GROUPS OF KIDS DIFFER IN MANY 2992 01:51:22,680 --> 01:51:24,240 WAYS TYPICALLY, HAVING 2993 01:51:24,240 --> 01:51:27,000 DIFFERENCES IN LEVELS OF STRESS, 2994 01:51:27,000 --> 01:51:28,800 DIFFER IN SOCIAL ECONOMIC 2995 01:51:28,800 --> 01:51:30,120 STATUS, PSYCHOPATHOLOGY, 2996 01:51:30,120 --> 01:51:31,560 COMMUNAL EXPOSURE, EXPOSURE TO 2997 01:51:31,560 --> 01:51:33,320 LEAD, I CAN LIST A HUNDRED 2998 01:51:33,320 --> 01:51:33,960 CONFOUNDSERS THAT ARE 2999 01:51:33,960 --> 01:51:36,960 CHALLENGING TO MEASURE CONTROLS 3000 01:51:36,960 --> 01:51:38,600 FOR THESE KIND OF BETWEEN PERSON 3001 01:51:38,600 --> 01:51:39,840 STUDIES BUT MORE IMPORTANT THAN 3002 01:51:39,840 --> 01:51:41,520 THAT, WHAT WE REALLY WANT TO 3003 01:51:41,520 --> 01:51:44,120 KNOW IS HOW STRESS IS PRODUCING 3004 01:51:44,120 --> 01:51:45,600 CHANGES WITHIN AN INDIVIDUAL. 3005 01:51:45,600 --> 01:51:47,520 RELATIVE TO THEIR OWN 3006 01:51:47,520 --> 01:51:49,120 FUNCTIONING WHEN IT HAPPENS SO I 3007 01:51:49,120 --> 01:51:51,600 AM SHOWING YOU THREE THEORETICAL 3008 01:51:51,600 --> 01:51:52,960 KIDS, ONE ON AVERAGE HIGHER 3009 01:51:52,960 --> 01:51:54,400 LEVELS OF STRESS, MORE MODERATE 3010 01:51:54,400 --> 01:51:56,040 AND LOWER LEVELS OF STRESS AND 3011 01:51:56,040 --> 01:51:57,680 TRADITIONAL APPROACH WOULD 3012 01:51:57,680 --> 01:51:59,080 SIMPLY COMPARE THESE AVERAGE 3013 01:51:59,080 --> 01:52:01,000 LEVELS OF STRESS ACROSS THE KIDS 3014 01:52:01,000 --> 01:52:02,240 AND ASSUME THAT IF WE SEE 3015 01:52:02,240 --> 01:52:03,720 DIFFERENCES IN THEIR BRAIN IT IS 3016 01:52:03,720 --> 01:52:05,000 BECAUSE OF STRESS BUT WHAT WE 3017 01:52:05,000 --> 01:52:07,160 REALLY WANTS TO KNOW FROM AN 3018 01:52:07,160 --> 01:52:08,120 INTERVENTION PERSPECTIVE AND 3019 01:52:08,120 --> 01:52:09,640 TRANSLATIONAL PERSPECTIVE IS 3020 01:52:09,640 --> 01:52:11,360 WHAT HAPPENS WHEN A KID 3021 01:52:11,360 --> 01:52:12,520 EXPERIENCES MORE STRESS THAN IS 3022 01:52:12,520 --> 01:52:15,080 TYPICAL FOR THEM? WHAT CHANGES 3023 01:52:15,080 --> 01:52:16,200 ABOUT THEIR BRAIN FUNCTION, 3024 01:52:16,200 --> 01:52:18,600 COGNITION, EMOTIONS, THAT THEN 3025 01:52:18,600 --> 01:52:21,200 PREDICTS EMERGENCE OF 3026 01:52:21,200 --> 01:52:22,240 PSYCHOPATHOLOGY? THAT IS WHAT WE 3027 01:52:22,240 --> 01:52:24,120 NEED TO UNDERSTAND TO LEVERAGE 3028 01:52:24,120 --> 01:52:25,960 MECHANISTIC RESEARCH INTO 3029 01:52:25,960 --> 01:52:27,040 INTERVENTION. SO IDENTIFYING 3030 01:52:27,040 --> 01:52:28,720 THESE MECHANISMS REQUIRES A 3031 01:52:28,720 --> 01:52:30,920 DESIGN THAT CAN CAPTURE THEM ON 3032 01:52:30,920 --> 01:52:32,200 THE TIME SCALE WHICH THEY 3033 01:52:32,200 --> 01:52:33,800 ACTUALLY UNFOLD IN REAL TIME. 3034 01:52:33,800 --> 01:52:37,000 WHICH IS TYPICALLY WEEKS OR 3035 01:52:37,000 --> 01:52:38,160 MONTHS SO IN THE PILOT STUDY I 3036 01:52:38,160 --> 01:52:40,720 WILL SHOW YOU A SNEAK PEAK 3037 01:52:40,720 --> 01:52:42,440 ONGOING R 37 WE BRING 3038 01:52:42,440 --> 01:52:43,560 ADOLESCENTS IN THE LAB ONCE A 3039 01:52:43,560 --> 01:52:45,840 MONTHS FOR AN ENTIRE YEAR. WE 3040 01:52:45,840 --> 01:52:48,920 COLLECT DATA ON STRESS, EMOTION, 3041 01:52:48,920 --> 01:52:51,800 BEHAVIOR, BRAIN FUNCTION, 3042 01:52:51,800 --> 01:52:53,120 COGNITION, EACH MONTH SO WE CAN 3043 01:52:53,120 --> 01:52:55,080 SEE WHEN STRESS FLUCTUATES FOR 3044 01:52:55,080 --> 01:52:56,560 CHILDREN RELATIVE TO THEIR OWN 3045 01:52:56,560 --> 01:52:58,440 BASELINE, HOW DOES THAT PRODUCE 3046 01:52:58,440 --> 01:53:00,120 CHANGES IN THESE POTENTIAL 3047 01:53:00,120 --> 01:53:02,240 STRESS MECHANISMS? I WILL SHOW 3048 01:53:02,240 --> 01:53:05,560 YOU ONE EXAMPLE. SO BECAUSE IN 3049 01:53:05,560 --> 01:53:08,120 PERSON RESEARCH INCLUDING NOT 3050 01:53:08,120 --> 01:53:09,640 POSSIBLE AT THE BEGINNING OF THE 3051 01:53:09,640 --> 01:53:11,200 PANDEMIC I WILL SHOW YOU DATA 3052 01:53:11,200 --> 01:53:13,800 COLLECTED BEFORE THE PANDEMIC 3053 01:53:13,800 --> 01:53:14,680 STARTED. WE WERE EXAMINING 3054 01:53:14,680 --> 01:53:16,840 NEURAL RESPONSES TO A REALLY 3055 01:53:16,840 --> 01:53:18,560 STANDARD TASK THAT LOOKS AT 3056 01:53:18,560 --> 01:53:21,120 RESPONSES TO AVERSIVE STIMULI. 3057 01:53:21,120 --> 01:53:23,080 RESPONSES TO FEARFUL FACES WHICH 3058 01:53:23,080 --> 01:53:24,600 SUGGEST COULD BE A THREAT IN THE 3059 01:53:24,600 --> 01:53:25,680 ENVIRONMENT. RELATIVE TO FACES 3060 01:53:25,680 --> 01:53:29,600 THAT ARE NEUTRAL. AND WHAT YOU 3061 01:53:29,600 --> 01:53:31,760 SEE IN THIS MAP IN WARM COLORS 3062 01:53:31,760 --> 01:53:33,400 ARE REGIONS OF THE BRAIN WE SEE 3063 01:53:33,400 --> 01:53:35,560 WITHIN PERSON CHANGES. SO 3064 01:53:35,560 --> 01:53:37,240 RELATIVE TO YOUR OWN LEVEL OF 3065 01:53:37,240 --> 01:53:38,840 BRAIN RESPONSE TO THIS TASK ON 3066 01:53:38,840 --> 01:53:41,760 MONTHS WHEN YOU EXPERIENCE MORE 3067 01:53:41,760 --> 01:53:44,520 STRESS AND THAN NORMAL FOR YOU 3068 01:53:44,520 --> 01:53:45,920 HOW DOES BRAIN FUNCTION 3069 01:53:45,920 --> 01:53:47,520 FLUCTUATE? WARM REGIONS 3070 01:53:47,520 --> 01:53:49,040 RESPONDING MORE TO AVERSIVE 3071 01:53:49,040 --> 01:53:51,160 STIMULI ON MONTHS CONTACT RISED 3072 01:53:51,160 --> 01:53:52,600 BY HIGHER LEVELS OF STRESS AND 3073 01:53:52,600 --> 01:53:55,520 BLUE COLORS ARE REGIONS 3074 01:53:55,520 --> 01:53:57,400 RESPONDING LESS. SO WHAT WE SEE 3075 01:53:57,400 --> 01:54:00,400 SORT OF INCREASE -- DECREASED 3076 01:54:00,400 --> 01:54:02,200 ACTIVITY AND MULTIPLE NODES OF 3077 01:54:02,200 --> 01:54:03,840 FRONTAL PARIETAL NETWORK IN 3078 01:54:03,840 --> 01:54:06,800 REGIONS WE ASSOCIATE WITH 3079 01:54:06,800 --> 01:54:08,960 COGNITIVE CONTROL INCLUDING 3080 01:54:08,960 --> 01:54:11,640 DORSAL CINGULATE CORTEX. 3081 01:54:11,640 --> 01:54:15,280 MULTIPLE REGIONS OF LATERAL PFC, 3082 01:54:15,280 --> 01:54:17,880 THE MFG AND IFG. THIS IS 3083 01:54:17,880 --> 01:54:20,720 INTERESTING, THIS REPLY CASE 3084 01:54:20,720 --> 01:54:22,800 RECENT WORK IN MY LAB, IN 3085 01:54:22,800 --> 01:54:24,840 BETWEEN PERSON LONGITUDINAL 3086 01:54:24,840 --> 01:54:27,600 STUDY KIDS EXPOSE TO MAL TREAT 3087 01:54:27,600 --> 01:54:29,040 ONCE YOU ADJUST FOR THIS 3088 01:54:29,040 --> 01:54:31,280 RECRUITSMENT IN FRONTAL PARIETAL 3089 01:54:31,280 --> 01:54:33,560 TREATMENT, IN AVERSIVE QUEUES 3090 01:54:33,560 --> 01:54:34,360 CUTS ACROSS MULTIPLE FORMS OF 3091 01:54:34,360 --> 01:54:35,800 STRESS AN ADVERSITY TO INCREASE 3092 01:54:35,800 --> 01:54:38,640 RISK FOR DEPRESSION AND ANXIETY, 3093 01:54:38,640 --> 01:54:40,520 BUT WE ALSO SEE INCREASE 3094 01:54:40,520 --> 01:54:41,840 RECRUITMENT IN MULTIPLE REGIONS 3095 01:54:41,840 --> 01:54:44,480 OF THE DEFAULT MODE NETWORK 3096 01:54:44,480 --> 01:54:45,840 INCLUDING VENTRAL MEDIAL 3097 01:54:45,840 --> 01:54:49,320 PREFRONTAL CORTEX, POSTERIOR 3098 01:54:49,320 --> 01:54:51,560 CINGULATE, ANGULAR GYRUS AND 3099 01:54:51,560 --> 01:54:52,920 CORTEX, WHAT IS INTERESTING IS 3100 01:54:52,920 --> 01:54:55,520 THIS IS A PATTERN WE DON'T SEE 3101 01:54:55,520 --> 01:54:56,520 IN BETWEEN PERSON AND CROSS 3102 01:54:56,520 --> 01:54:58,520 SECTIONAL STUDIES. WHAT IS OF 3103 01:54:58,520 --> 01:55:00,720 NOTE IS THESE REGIONS OF 3104 01:55:00,720 --> 01:55:02,440 DEFAULTS MODE NETWORK, INCREASE 3105 01:55:02,440 --> 01:55:06,200 RESPONSE TO AVERSESSAL QUEUES 3106 01:55:06,200 --> 01:55:09,320 WHICH SUGGEST INCREASE 3107 01:55:09,320 --> 01:55:10,160 SELF-THINKING LIKE RUMINATION ON 3108 01:55:10,160 --> 01:55:11,440 MONTHS CHARACTER RIDESSED BY 3109 01:55:11,440 --> 01:55:12,400 HIGHER THAN USUAL STRESS, THESE 3110 01:55:12,400 --> 01:55:15,920 ARE REGIONS STRONGLY PREDICTED 3111 01:55:15,920 --> 01:55:17,800 INCREASE IN SYMPTOMS OF ANXIETY 3112 01:55:17,800 --> 01:55:19,480 AND DEPRESSION FOLLOWING MONTH 3113 01:55:19,480 --> 01:55:21,520 SO R 37 BEEXAMINE IN PERSON 3114 01:55:21,520 --> 01:55:23,440 FLUCTUATIONS IN RESPONSE TO MUCH 3115 01:55:23,440 --> 01:55:24,960 WIDER RANGE OF TASK AN LARGER 3116 01:55:24,960 --> 01:55:27,720 SAMPLES SO STAY TUNED, I WILL 3117 01:55:27,720 --> 01:55:29,560 COME BACK WITH SOMEDEAL DATA 3118 01:55:29,560 --> 01:55:31,400 TELLING YOU WHAT WE FIND. I WILL 3119 01:55:31,400 --> 01:55:33,280 END BY TALKING ABOUT THE 3120 01:55:33,280 --> 01:55:34,680 CLINICAL IMPLICATIONS OF THE 3121 01:55:34,680 --> 01:55:35,960 EMERGING DATA I JUST SHARED WITH 3122 01:55:35,960 --> 01:55:39,200 YOU. SO THIS KIND OF EMERGING 3123 01:55:39,200 --> 01:55:40,440 EVERYDAY ON STRESS AN 3124 01:55:40,440 --> 01:55:41,080 PSYCHOPATHOLOGY CAN BE LEARNED 3125 01:55:41,080 --> 01:55:42,760 IN TWO WAYS. TO THINK ABOUT -- 3126 01:55:42,760 --> 01:55:44,360 LEVERAGED IN INFORMING 3127 01:55:44,360 --> 01:55:46,280 INTERVENTION TO PREVENTS STRESS 3128 01:55:46,280 --> 01:55:47,600 RELATED PSYCHOPATHOLOGY AS THE 3129 01:55:47,600 --> 01:55:48,640 PANDEMIC CONTINUES. BEFORE I 3130 01:55:48,640 --> 01:55:52,920 TALK ABOUT THAT, I WANT TO 3131 01:55:52,920 --> 01:55:54,440 HIGHLIGHT A KEY ISSUE, HOW TO 3132 01:55:54,440 --> 01:55:56,680 REACH PEOPLE IN NEEDS. I THINK 3133 01:55:56,680 --> 01:55:57,400 IT GOES WITHOUT SAYING THAT 3134 01:55:57,400 --> 01:55:59,760 ACCESS TO MENTAL HEALTH SERVICES 3135 01:55:59,760 --> 01:56:00,680 DURING THE PANDEMIC HAS BECOME 3136 01:56:00,680 --> 01:56:01,680 MORE CHALLENGING AS THE NEEDS 3137 01:56:01,680 --> 01:56:03,840 FOR THOSE SERVICES HAS INCREASED 3138 01:56:03,840 --> 01:56:05,760 SUBSTANTIALLY. WE ALSO KNOW THAT 3139 01:56:05,760 --> 01:56:07,240 DISPARITIES RACIAL AND ETHNIC 3140 01:56:07,240 --> 01:56:09,040 DISPARITIES AND ACCESS TO MENTAL 3141 01:56:09,040 --> 01:56:10,880 HEALTH SERVICES HAVE WIDEN AND 3142 01:56:10,880 --> 01:56:12,400 BECOME MORE PRONOUNCED DURING 3143 01:56:12,400 --> 01:56:15,640 THE PANDEMIC AND FAMILY WHOSE 3144 01:56:15,640 --> 01:56:16,600 ARE MOST VULNERABLE TO STRESS 3145 01:56:16,600 --> 01:56:18,160 RELATED PSYCHOPATHOLOGY AS A 3146 01:56:18,160 --> 01:56:20,280 RESULT OF CUMULATIVE EXPOSURE 3147 01:56:20,280 --> 01:56:21,200 MAYBE LYSES LIKELY TO HAVE TIME 3148 01:56:21,200 --> 01:56:22,840 OR RESOURCES TO SEEK OUTS 3149 01:56:22,840 --> 01:56:25,240 INTENSIVE MENTAL HEALTH SERVICE. 3150 01:56:25,240 --> 01:56:27,560 SO IN LIGHT OF THAT, I WILL 3151 01:56:27,560 --> 01:56:30,560 FOCUS IN PARTICULAR ON THINKING 3152 01:56:30,560 --> 01:56:32,040 ABOUT BRIEF DIGITAL KINDS OF 3153 01:56:32,040 --> 01:56:35,000 INTERVENTIONS THAT HAVE THE 3154 01:56:35,000 --> 01:56:36,840 POTENTIAL TO BE SCALED TO HELP 3155 01:56:36,840 --> 01:56:37,880 ADDRESS INCREASE NEED IN WAYS 3156 01:56:37,880 --> 01:56:40,440 ACTUALLY FEASIBLE. MORE FEASIBLE 3157 01:56:40,440 --> 01:56:42,000 THAN JUST THINKING EVERYBODY IS 3158 01:56:42,000 --> 01:56:45,800 GOING TO RECEIVE SPECIALTY 3159 01:56:45,800 --> 01:56:46,440 MENTAL HEALTH SERVICE WHICH IS 3160 01:56:46,440 --> 01:56:47,960 IS NOT REALISTIC. SO THE 3161 01:56:47,960 --> 01:56:49,080 ENVIRONMENTAL STRESS MODELS I 3162 01:56:49,080 --> 01:56:51,480 STARTED WITH THAT ARE FOCUSED ON 3163 01:56:51,480 --> 01:56:53,200 ENVIRONMENTAL CONCEPTUALIZATION 3164 01:56:53,200 --> 01:56:55,520 OF STRESS CAN HIGHLIGHT THE 3165 01:56:55,520 --> 01:56:56,920 CHARACTERISTICS OF STRESSORS 3166 01:56:56,920 --> 01:56:59,480 THAT MIGHT BE IMPORTANT FOR 3167 01:56:59,480 --> 01:57:01,000 IDENTIFYING WHO IS IN NEED OF 3168 01:57:01,000 --> 01:57:03,200 INTERVENTION. SO WHAT WE LEARN 3169 01:57:03,200 --> 01:57:05,080 FROM THIS EMERGING WORK IS THAT 3170 01:57:05,080 --> 01:57:07,680 SORT OF UNSURPRISINGLY FAMILIES 3171 01:57:07,680 --> 01:57:09,280 WITH HIGH LEVELS OF CHRONIC AND 3172 01:57:09,280 --> 01:57:11,480 CUMULATIVE STRESS EXPOSURE 3173 01:57:11,480 --> 01:57:12,240 PARTICULARLY RELATED TO THINGS 3174 01:57:12,240 --> 01:57:14,680 LIKE ONGOING FINANCIAL 3175 01:57:14,680 --> 01:57:18,440 ADVERSITY, AND DISRUPTIONS IN DA 3176 01:57:18,440 --> 01:57:24,880 DAILY LIFE ARE VULNERABLE TO 3177 01:57:24,880 --> 01:57:25,960 PSYCHOPATHOLOPATHOLOGY. HEALTHCE 3178 01:57:25,960 --> 01:57:26,520 WORKERS AND THEIR CHILDREN, 3179 01:57:26,520 --> 01:57:28,000 BECAUSE THEY WORK IN INDUSTRIES 3180 01:57:28,000 --> 01:57:29,640 THAT HAVE BEEN AFFECTED IN AN AN 3181 01:57:29,640 --> 01:57:32,320 GOING WAY BY THE PANDEMIC LIKE 3182 01:57:32,320 --> 01:57:34,840 RESTAURANT OR HOSPITALITY 3183 01:57:34,840 --> 01:57:35,560 SERVICE. FAMILIES WHO -- 3184 01:57:35,560 --> 01:57:39,920 CHILDREN WHO EXPERIENCED ONGOING 3185 01:57:39,920 --> 01:57:41,960 SOCIAL ISOLATION AND 3186 01:57:41,960 --> 01:57:43,040 DISCONNECTION FROM PEERS SEEM TO 3187 01:57:43,040 --> 01:57:45,560 BE PARTICULARLY LIKELY TO 3188 01:57:45,560 --> 01:57:46,760 DEVELOP PSYCHOPATHOLOGY DURING 3189 01:57:46,760 --> 01:57:49,600 THE ADVERSITY AND UNSURPRISINGLY 3190 01:57:49,600 --> 01:57:51,400 KIDS WHO HAVE HISTORY OF TRAUMA 3191 01:57:51,400 --> 01:57:53,080 OR OTHER FORMS OF EARLY LIFE 3192 01:57:53,080 --> 01:57:56,200 ADVERSITY WE KNOW IN GLOBAL WAY 3193 01:57:56,200 --> 01:57:57,800 ARE MORE VULNERABLE TO 3194 01:57:57,800 --> 01:57:59,240 PSYCHOPATHOLOGY IN GENERAL. 3195 01:57:59,240 --> 01:58:02,200 THAT'S MIREED FROM THE DATA WE 3196 01:58:02,200 --> 01:58:03,640 SEE IN PANDEMIC. I HAVE NOT 3197 01:58:03,640 --> 01:58:05,000 ENCOUNT IRED RESEARCH ON 3198 01:58:05,000 --> 01:58:07,760 CHILDREN AND AD LET SENSE BUT 3199 01:58:07,760 --> 01:58:09,800 AMONG ADULTS THOUGH WHITE ADULT 3200 01:58:09,800 --> 01:58:11,600 VERSUS THE HIGHEST LEVELS OF 3201 01:58:11,600 --> 01:58:13,280 ANXIETY AND DEPRESSION BEFORE 3202 01:58:13,280 --> 01:58:15,720 THE PANDEMIC, THAT THE RELATIVE 3203 01:58:15,720 --> 01:58:19,000 INCREASE IN MENTAL DISORDERS WAS 3204 01:58:19,000 --> 01:58:20,480 HIGHER FOR ASIAN AMERICANS, 3205 01:58:20,480 --> 01:58:22,480 BLACK AMERICANS, LATINX 3206 01:58:22,480 --> 01:58:23,560 AMERICANS, THAN WHITES DURING 3207 01:58:23,560 --> 01:58:25,320 THE PANDEMIC. SO SORT OF 3208 01:58:25,320 --> 01:58:26,800 INCREASING HEALTH DISPARITIES AS 3209 01:58:26,800 --> 01:58:28,360 WELL AS INCREASING DISPARITIES 3210 01:58:28,360 --> 01:58:31,920 IN ACCESS TO SERVICES, FOR FOLKS 3211 01:58:31,920 --> 01:58:33,360 IN THESE GROUPS. 3212 01:58:33,360 --> 01:58:34,920 I HAVE NOT SEEN THE DATA ON THIS 3213 01:58:34,920 --> 01:58:36,680 IN CHILDREN AND WANT TO 3214 01:58:36,680 --> 01:58:38,480 HIGHLIGHT THAT WE EXPECT THAT 3215 01:58:38,480 --> 01:58:39,240 SIMILAR PATTERNS MIGHT BE TRUE 3216 01:58:39,240 --> 01:58:41,800 FOR KIDS, THIS IS AN UNDERSTUDY 3217 01:58:41,800 --> 01:58:43,920 AREA THAT NEEDS MORE ATTENTION. 3218 01:58:43,920 --> 01:58:48,480 THEN FINALLY, WHEN WE THINK 3219 01:58:48,480 --> 01:58:50,160 ABOUT STRESS PATHWAY MODELS THAT 3220 01:58:50,160 --> 01:58:51,840 HELP THINK ABOUT HOW YOU MIGHT 3221 01:58:51,840 --> 01:58:53,760 INTERVENE, WHAT IS THE CONTENT 3222 01:58:53,760 --> 01:58:55,240 OF INTERVENTIONS THAT MIGHT BE 3223 01:58:55,240 --> 01:58:56,720 HELPFUL TO PREVENT STRESS 3224 01:58:56,720 --> 01:58:59,280 RELATED PSYCHOPATHOLOGY. FIRST 3225 01:58:59,280 --> 01:59:02,000 WITH REGARD TO THAT CONTENT, 3226 01:59:02,000 --> 01:59:03,720 INTERVENTIONS TARGETING STRESS 3227 01:59:03,720 --> 01:59:05,640 APPRAISALS OR REAPPRAISAL ARE 3228 01:59:05,640 --> 01:59:07,440 ONE PROMISING AVENUE. THAT MIGHT 3229 01:59:07,440 --> 01:59:09,240 SEEM A TIRED SUGGESTION BECAUSE 3230 01:59:09,240 --> 01:59:10,360 COGNITIVE RESTRUCTURING IS A 3231 01:59:10,360 --> 01:59:13,320 MAIN STAY OF CBT FOR 20, 30 3232 01:59:13,320 --> 01:59:15,720 YEARS. WHAT IS INTERESTING THERE 3233 01:59:15,720 --> 01:59:18,440 IS RECENT WORK SUGGESTING THAT 3234 01:59:18,440 --> 01:59:20,440 VERY BRIEF SELF GUIDED DIGITAL 3235 01:59:20,440 --> 01:59:21,600 INTERVENTIONS THAT ARE DELIVERED 3236 01:59:21,600 --> 01:59:22,920 ESSENTIALLY THROUGH VIDEOS 3237 01:59:22,920 --> 01:59:24,920 ONLINE THAT TEACH PEOPLE TO 3238 01:59:24,920 --> 01:59:27,080 REAPPRAISE STRESS TO THINK ABOUT 3239 01:59:27,080 --> 01:59:29,120 ADAPTIVE BENEFITS, HAVE HAD 3240 01:59:29,120 --> 01:59:30,760 POSITIVE IMPACT THROUGH SINGLE 3241 01:59:30,760 --> 01:59:32,160 SESSION INTERVENTIONS, SOME 3242 01:59:32,160 --> 01:59:34,640 THINGS LIKE ANXIETY, DEPRESSION, 3243 01:59:34,640 --> 01:59:36,680 AND EVEN PHYSIOLOGICAL RESPONSES 3244 01:59:36,680 --> 01:59:39,520 TO STRESS. THESE KINDS OF ONLINE 3245 01:59:39,520 --> 01:59:41,000 INTERVENTIONS WERE ADAPTED BY 3246 01:59:41,000 --> 01:59:42,560 SOME GROUPS DURING THE PANDEMIC 3247 01:59:42,560 --> 01:59:43,840 TO TARGET SPECIFIC KINDS OF 3248 01:59:43,840 --> 01:59:45,760 STRESSORS LIKE RELATIONSHIP 3249 01:59:45,760 --> 01:59:48,040 CONFLICT AND ALSO A POSITIVE 3250 01:59:48,040 --> 01:59:49,280 INFLUENCES ON RESPONSES TO 3251 01:59:49,280 --> 01:59:50,400 STRESS DURING THE PANDEMIC SO 3252 01:59:50,400 --> 01:59:53,120 THINKING ABOUT HOW TO INCREASE 3253 01:59:53,120 --> 01:59:54,600 ACCESS, IMPLEMENT AND 3254 01:59:54,600 --> 01:59:56,200 DISSEMINATE THESE KINDS OF 3255 01:59:56,200 --> 01:59:57,640 INTERVENTIONS INSTEAD OF ONE 3256 01:59:57,640 --> 01:59:59,920 POTENTIALLY USEFUL STRATEGY. I 3257 01:59:59,920 --> 02:00:01,720 THINK PSYCHOLOGISTS WE ALWAYS 3258 02:00:01,720 --> 02:00:02,760 THINK ABOUT PSYCHOSOCIAL 3259 02:00:02,760 --> 02:00:05,200 INTERVENTIONS THAT ARE FOCUS ON 3260 02:00:05,200 --> 02:00:07,000 CHANGING THE WAY YOU THINK, HOW 3261 02:00:07,000 --> 02:00:09,920 WE PROCESS EMOTION, THE STRESS 3262 02:00:09,920 --> 02:00:12,800 BUFFERSNA HAVE EMERGED IN 3263 02:00:12,800 --> 02:00:13,440 RESEARCH DURING THE PANDEMIC 3264 02:00:13,440 --> 02:00:14,640 PHYSICAL ACTIVITY SCREEN TIME, 3265 02:00:14,640 --> 02:00:16,040 THERE ARE BRIEF DIGITAL 3266 02:00:16,040 --> 02:00:17,280 BEHAVIORAL KINDS OF 3267 02:00:17,280 --> 02:00:18,800 INTERVENTIONS THAT EXIST TO 3268 02:00:18,800 --> 02:00:19,840 TARGET THESE STRESS BUFFERS THAT 3269 02:00:19,840 --> 02:00:21,440 ARE WIDELY AVAILABLE AND 3270 02:00:21,440 --> 02:00:23,160 THINKING ABOUT HOW TO LEVERAGE 3271 02:00:23,160 --> 02:00:26,800 THESE EXISTING INTERVENTIONS, TO 3272 02:00:26,800 --> 02:00:28,440 PREVENTS OR REDUCE STRESS 3273 02:00:28,440 --> 02:00:29,760 RELATED PSYCHOPATHOLOGY IS 3274 02:00:29,760 --> 02:00:31,280 ANOTHER PROMISING AREA THAT WE 3275 02:00:31,280 --> 02:00:33,480 DON'T FOCUS ON AS MUCH IN THE 3276 02:00:33,480 --> 02:00:36,280 MENTAL HEALTH SPHERE AS WE 3277 02:00:36,280 --> 02:00:37,560 COULD, AS ONE SIMPLE EXAMPLE, 3278 02:00:37,560 --> 02:00:39,400 ADULTSES WHO PARTICIPATED IN 3279 02:00:39,400 --> 02:00:40,680 DIGITAL PLATFORMS FOR PHYSICAL 3280 02:00:40,680 --> 02:00:42,040 ACTIVITY, SO LIKE A STREAMING 3281 02:00:42,040 --> 02:00:42,800 SERVICE OR SOMETHING THAT GAVE 3282 02:00:42,800 --> 02:00:44,680 YOU ACCESS TO SOME PHYSICAL 3283 02:00:44,680 --> 02:00:46,360 ACTIVITY CONTENT DURING THE 3284 02:00:46,360 --> 02:00:47,920 PANDEMIC MAINTAINED HIGHER 3285 02:00:47,920 --> 02:00:49,640 LEVELS OF PHYSICAL ACTIVITY WERE 3286 02:00:49,640 --> 02:00:52,160 LESS LIKELY TO DEVELOP STRESS 3287 02:00:52,160 --> 02:00:55,280 RELATED PSYCHOPATHOLOGY. THEN 3288 02:00:55,280 --> 02:00:56,560 FINALLY, I WANT TO GIVE A SHOUT 3289 02:00:56,560 --> 02:00:58,920 OUT TO EMERGING WORK ON SELF 3290 02:00:58,920 --> 02:00:59,920 GUIDED BRIEF DIGITAL 3291 02:00:59,920 --> 02:01:02,320 INTERVENTIONS INCLUDING SINGLE 3292 02:01:02,320 --> 02:01:04,360 SESSION INTERVENTIONS. SORT OF A 3293 02:01:04,360 --> 02:01:05,640 ACCUMULATING EVIDENCE SUGGESTS 3294 02:01:05,640 --> 02:01:07,360 THESE VERY BRIEF SINGLE SESSION 3295 02:01:07,360 --> 02:01:08,720 INTERVENTIONS CAN LEAD TO 3296 02:01:08,720 --> 02:01:11,120 LASTING CHANGES IN SYMPTOMS OF 3297 02:01:11,120 --> 02:01:12,280 DEPRESSION, ANXIETY AND SOME OF 3298 02:01:12,280 --> 02:01:14,640 THESE INTERVENTIONS TARGET 3299 02:01:14,640 --> 02:01:18,760 STRESS MECHANISMS SO JESSICA 3300 02:01:18,760 --> 02:01:21,840 SCHNEIDERS LAB PUBLISHED A 3301 02:01:21,840 --> 02:01:23,320 INTERESTING SINGLE INTERESTING 3302 02:01:23,320 --> 02:01:23,920 BEHAVIOR INTERVENTION CONDUCT 3303 02:01:23,920 --> 02:01:26,400 WITH ADOLESCENTS DURING THE 3304 02:01:26,400 --> 02:01:27,480 COVID-19 PANDEMIC ONE SESSION 3305 02:01:27,480 --> 02:01:28,800 THAT LED TO SIGNIFICANT 3306 02:01:28,800 --> 02:01:30,400 REDUCTIONS IN SYMPTOMS OF 3307 02:01:30,400 --> 02:01:31,640 DEPRESSION OVER TIME. AND I 3308 02:01:31,640 --> 02:01:33,040 THINK FINDING WAYS TO 3309 02:01:33,040 --> 02:01:34,840 DISSEMINATE AND INCREASE ACCESS 3310 02:01:34,840 --> 02:01:36,360 TO THESE BRIEF SELF-GUIDED 3311 02:01:36,360 --> 02:01:38,080 INTERVENTIONS MAYBE ONE FEASIBLE 3312 02:01:38,080 --> 02:01:40,760 STRATEGY FOR REDUCING STRESS 3313 02:01:40,760 --> 02:01:43,760 RELATED SYMPTOMATOLOGY AS THE 3314 02:01:43,760 --> 02:01:45,160 PANDEMIC CONTINUES. TO WRAP UP I 3315 02:01:45,160 --> 02:01:47,760 HAVE SHOWN YOU DATA INCREASES IN 3316 02:01:47,760 --> 02:01:50,200 OUR EXPERIENCES OF STRESS ARE 3317 02:01:50,200 --> 02:01:51,040 MAYER JOE CONTRIBUTOR TO 3318 02:01:51,040 --> 02:01:52,720 SYMPTOMS OF PSYCHOPATHOLOGY WE 3319 02:01:52,720 --> 02:01:53,400 OBVIOUS SEVERED THE PAST COUPLE 3320 02:01:53,400 --> 02:01:55,200 OF YEARS IN CHILDREN. AND THAT 3321 02:01:55,200 --> 02:01:57,280 WHEN WE THINK ABOUT WHO IS MOST 3322 02:01:57,280 --> 02:02:00,160 VULNERABLE WE KNOW A LOT, GIVEN 3323 02:02:00,160 --> 02:02:01,320 PRIOR WORK AND EMERGING WORK 3324 02:02:01,320 --> 02:02:03,480 FROM THE PANDEMIC, ON STRESS 3325 02:02:03,480 --> 02:02:04,880 RELATED VULNERABILITY TO STRESS 3326 02:02:04,880 --> 02:02:07,240 RELATED PSYCHOPATHOLOGY. AND 3327 02:02:07,240 --> 02:02:09,120 THAT WE CAN LEVERAGE EMERGING 3328 02:02:09,120 --> 02:02:11,760 WORK ON MECHANISMS THAT LINK 3329 02:02:11,760 --> 02:02:12,640 EXPERIENCES OF STRESSFUL 3330 02:02:12,640 --> 02:02:15,160 PSYCHOPATHOLOGY TO THINK ABOUT 3331 02:02:15,160 --> 02:02:17,880 WAYS WE CAN TARGET OR REDUCE 3332 02:02:17,880 --> 02:02:18,840 STRESS RELATED PSYCHOPATHOLOGY 3333 02:02:18,840 --> 02:02:20,840 IN CHILDREN VULNERABLE. ONE 3334 02:02:20,840 --> 02:02:22,120 FINAL SHOUT OUT, I WANT TO MAKE 3335 02:02:22,120 --> 02:02:23,480 SURE I GIVE CREDIT WHERE IT IS 3336 02:02:23,480 --> 02:02:26,000 DUE TO THE AMAZING EARLY CAREER 3337 02:02:26,000 --> 02:02:27,160 SHINTIESES IN MY LAB. WHO LED 3338 02:02:27,160 --> 02:02:28,360 MOST OF THE DATA I SHOWED YOU 3339 02:02:28,360 --> 02:02:29,840 FROM MY OWN LAB. I ALSO WANT TO 3340 02:02:29,840 --> 02:02:31,280 THANK THE PEOPLE IN THIS ROOM 3341 02:02:31,280 --> 02:02:33,120 BECAUSE THESE ARE ALL SCIENTISTS 3342 02:02:33,120 --> 02:02:35,840 SUPPORTED BY NIH, ALEXANDER 3343 02:02:35,840 --> 02:02:40,240 RODMAN WHO HAS A K99 FROM NIMH 3344 02:02:40,240 --> 02:02:43,600 AND DAVID WISEMAN WHO JUST GOT A 3345 02:02:43,600 --> 02:02:48,120 K99 AND MAYA ROSEN, LED A LOT OF 3346 02:02:48,120 --> 02:02:49,320 WORK YOU SAW TODAY SO SHOUT OUT 3347 02:02:49,320 --> 02:02:50,160 TO THEM APPROXIMATE THANK YOU TO 3348 02:02:50,160 --> 02:02:51,600 ALL OF YOU FOR SUPPORTING THESE 3349 02:02:51,600 --> 02:02:53,600 AMAZING YOUNG SCIENTISTS. THAT 3350 02:02:53,600 --> 02:02:55,960 IS I WILL WRAP THERE. WANT TO 3351 02:02:55,960 --> 02:02:57,360 THANK MY LAB AND NIMH FOR THE 3352 02:02:57,360 --> 02:02:58,120 FUNDING THAT SUPPORTED MOST OF 3353 02:02:58,120 --> 02:03:00,240 THE WORK THAT YOU SAW TODAY. I'M 3354 02:03:00,240 --> 02:03:01,640 GOING TO STOP SHARING MY SCREEN 3355 02:03:01,640 --> 02:03:02,840 AND HAPPY TO ANSWER ANY 3356 02:03:02,840 --> 02:03:13,240 QUESTIONS PEOPLE HAVE. 3357 02:03:15,520 --> 02:03:16,320 >> THANK YOU FOR THAT WONDERFUL 3358 02:03:16,320 --> 02:03:17,360 TALK. JOSEPH YOU PUT QUESTIONS 3359 02:03:17,360 --> 02:03:19,760 IN THE CHAT. WOULD YOU LIKE THE 3360 02:03:19,760 --> 02:03:20,760 ASK THEM OUT LOUD? 3361 02:03:20,760 --> 02:03:23,760 >> GREAT QUESTION, 7 TO 15, THE 3362 02:03:23,760 --> 02:03:25,200 TEENAGERS THE CHILDREN AND 3363 02:03:25,200 --> 02:03:26,440 TEENAGERS IN THE SAMPLE FROM MY 3364 02:03:26,440 --> 02:03:29,960 LAB. 3365 02:03:29,960 --> 02:03:31,240 DID YOU CONSIDER -- SO SECOND 3366 02:03:31,240 --> 02:03:32,840 QUESTION IS DID YOU CONSIDER 3367 02:03:32,840 --> 02:03:35,080 COMPOUND VARIABLES IN PHYSICAL 3368 02:03:35,080 --> 02:03:36,120 AND SOCIAL ENVIRONMENT, IS 3369 02:03:36,120 --> 02:03:37,240 INTERACTIONS BETWEEN STRESSORS. 3370 02:03:37,240 --> 02:03:39,760 WE DIDN'T SO WE LOOKED AT HOW 3371 02:03:39,760 --> 02:03:42,120 ACCUMULATION OF STRESS AND HOW 3372 02:03:42,120 --> 02:03:43,520 PSYCHOPATHOLOGY AND LOOKED AT 3373 02:03:43,520 --> 02:03:44,800 WHETHER THERE WAS DIFFERENTIAL 3374 02:03:44,800 --> 02:03:46,000 INFLUENCE OF PARTICULAR STRESSOR 3375 02:03:46,000 --> 02:03:48,520 TYPES WE DIDN'T LOOK AT WHETHER 3376 02:03:48,520 --> 02:03:50,080 THERE WERE PARTICULAR 3377 02:03:50,080 --> 02:03:50,960 INTERACTIONS WHETHER YOU HAD 3378 02:03:50,960 --> 02:03:52,000 SOCIAL STRESS AND HAVING TROUBLE 3379 02:03:52,000 --> 02:03:53,640 AT SCHOOL DID THAT COMPOUND THE 3380 02:03:53,640 --> 02:03:55,120 EFFECT OF ONE COMPOUND THE 3381 02:03:55,120 --> 02:03:56,120 OTHER, I WOULD GUESS PROBABLY 3382 02:03:56,120 --> 02:03:58,800 YES. WE DIDN'T EXAMINE THAT IN 3383 02:03:58,800 --> 02:04:06,600 OUR DATA. DO YOU WANT TO 3384 02:04:06,600 --> 02:04:07,360 SUMMARIZE THE THIRD QUESTION? 3385 02:04:07,360 --> 02:04:09,040 >> THANK YOU FOR THE VERY GOOD 3386 02:04:09,040 --> 02:04:10,320 PRESENTATION AND JUST POINTING 3387 02:04:10,320 --> 02:04:11,520 CLARIFICATION, WHY I ASKED ABOUT 3388 02:04:11,520 --> 02:04:14,480 THE COMPOUND VARIABLE. BECAUSE 3389 02:04:14,480 --> 02:04:16,960 ONE OF THE THINGS THAT A LOT OF 3390 02:04:16,960 --> 02:04:19,000 THE EMERGING WORK COMING OUT OF 3391 02:04:19,000 --> 02:04:20,640 THOSE THAT HAVE DONE STUDIESES 3392 02:04:20,640 --> 02:04:22,080 WITH THE COLLEGE AGE STUDENTS 3393 02:04:22,080 --> 02:04:25,760 ARE FINDING THAT THERE ARE 3394 02:04:25,760 --> 02:04:27,800 COMPOUNDS THERE, AND THAT IS 3395 02:04:27,800 --> 02:04:31,480 REALLY MORE PREDICTIVE EVEN 3396 02:04:31,480 --> 02:04:33,480 SOMETIMES IN MANY CASES IN 3397 02:04:33,480 --> 02:04:34,960 ISOLATION SO I WANTED TO BRING 3398 02:04:34,960 --> 02:04:36,160 THAT UP BECAUSE SINCE YOU ARE 3399 02:04:36,160 --> 02:04:37,880 LOOKING AT ADOLESCENT AND TRYING 3400 02:04:37,880 --> 02:04:39,040 TO LOOK AT INTERVENTIONS YOU 3401 02:04:39,040 --> 02:04:40,400 MENTIONED A LOT OF DIGITAL TYPE 3402 02:04:40,400 --> 02:04:42,440 OF THINGS, WHATEVER, SO I WANTED 3403 02:04:42,440 --> 02:04:46,080 TO BRING THAT UP BECAUSE THAT IS 3404 02:04:46,080 --> 02:04:49,120 VERY MUCH RELATED. IF YOU AND 3405 02:04:49,120 --> 02:04:50,320 OTHERS HAVE A OPPORTUNITY TO 3406 02:04:50,320 --> 02:04:51,880 LOOK AT THAT YOU MIGHT CONSIDER 3407 02:04:51,880 --> 02:04:53,280 THAT LATER IN ADOLESCENTS 3408 02:04:53,280 --> 02:04:54,120 BECAUSE THAT'S WHAT SO MANY 3409 02:04:54,120 --> 02:04:55,560 PEOPLE ARE LOOKING. THE LAST 3410 02:04:55,560 --> 02:05:00,680 PART HAS MORE TO DO WITH THE 3411 02:05:00,680 --> 02:05:02,840 REALITY QUESTION. THIS INSTITUTE 3412 02:05:02,840 --> 02:05:07,200 IS VERY INVESTED IN LOOKING AT 3413 02:05:07,200 --> 02:05:10,000 THE TYPES OF WORK THAT CAN BE 3414 02:05:10,000 --> 02:05:12,240 DONE TO ADDRESS DISPARITIES 3415 02:05:12,240 --> 02:05:13,680 ACROSS THE BOARD. NOT JUST 3416 02:05:13,680 --> 02:05:15,320 ETHNIC ABOUT RACIAL DISPARITIES 3417 02:05:15,320 --> 02:05:16,680 BUT ALSO DISPARITIES RELATED TO 3418 02:05:16,680 --> 02:05:18,720 HOMELESSNESS AND OTHER THINGS. 3419 02:05:18,720 --> 02:05:20,920 SO IT BECOMES REALLY IMPORTANT 3420 02:05:20,920 --> 02:05:23,840 WHEN LOOKING AT CHILDREN AND 3421 02:05:23,840 --> 02:05:24,800 FAMILIES THAT THEY DO NOT 3422 02:05:24,800 --> 02:05:27,280 NECESSARILY HAVE ACCESS TO 3423 02:05:27,280 --> 02:05:29,560 THINGS LIKE INTERNET, ACCESS TO 3424 02:05:29,560 --> 02:05:30,840 A LOT OF THINGS MANY 3425 02:05:30,840 --> 02:05:31,800 INTERVENTIONS THAT I THINK ARE 3426 02:05:31,800 --> 02:05:32,880 EXCELLENT THAT YOU MENTIONED BUT 3427 02:05:32,880 --> 02:05:36,680 THEY DON'T HAVE ACCESS TO THOSE. 3428 02:05:36,680 --> 02:05:38,760 SO THE REAL QUESTION IS THAT 3429 02:05:38,760 --> 02:05:39,760 RECOMMENDATION BASED UPON YOUR 3430 02:05:39,760 --> 02:05:42,760 FINDINGS BASED UPON PEOPLE YOU 3431 02:05:42,760 --> 02:05:45,560 WORK WITH THAT THIS PANEL OR 3432 02:05:45,560 --> 02:05:47,360 THIS INSTITUTE CAN LOOK AT AS 3433 02:05:47,360 --> 02:05:48,680 CONSIDERING CONCEPTUALLY HOW IT 3434 02:05:48,680 --> 02:05:50,800 MIGHT BE WORKING. THAT IS WHAT 3435 02:05:50,800 --> 02:05:52,960 I'M LOOKING AT. IN PARTICULAR 3436 02:05:52,960 --> 02:05:55,920 ONE WAYS FUNDING CAN BE USED TO 3437 02:05:55,920 --> 02:05:57,280 THAT. A LOT OF THE PEOPLE WHO 3438 02:05:57,280 --> 02:06:00,400 ARE DOING THIS WORK ARE NOT AS 3439 02:06:00,400 --> 02:06:02,000 ADEPT AT GETTING THE FUNDING 3440 02:06:02,000 --> 02:06:06,160 EVEN THOUGH THEY ARE VERY MUCH 3441 02:06:06,160 --> 02:06:07,720 -- VERY CLEAR TO ABILITY 3442 02:06:07,720 --> 02:06:08,880 INTERVENE, JUST ARE NOT THAT 3443 02:06:08,880 --> 02:06:11,400 WAY. SO IT IS A COMBINATION 3444 02:06:11,400 --> 02:06:13,720 QUESTION OF REALLY HOW YOU GET 3445 02:06:13,720 --> 02:06:18,520 TO HARD TO REACH HARD TO ACCESS 3446 02:06:18,520 --> 02:06:20,520 HISTORICAL POPULATIONS AND 3447 02:06:20,520 --> 02:06:21,440 SECONDARILY HOW DO YOU SUPPORT 3448 02:06:21,440 --> 02:06:26,160 THOSE THAT ACTUALLY ARE ACTIVELY 3449 02:06:26,160 --> 02:06:27,800 DOING BOTH CLINICAL WORK AS WELL 3450 02:06:27,800 --> 02:06:30,880 AS TRYING TO BUILD RESEARCH 3451 02:06:30,880 --> 02:06:31,680 PARTICULARLY HEALTH SERVICE 3452 02:06:31,680 --> 02:06:33,320 RESEARCH PROJECTS RELATED IN 3453 02:06:33,320 --> 02:06:34,720 THAT DIRECTION. IT IS A LONG 3454 02:06:34,720 --> 02:06:36,440 QUESTION, IT IS A LOT BUT YOU 3455 02:06:36,440 --> 02:06:37,840 PRESENTED SOME REALLY GOOD STUFF 3456 02:06:37,840 --> 02:06:39,440 THAT GOT MY BRAIN RUNNING SO 3457 02:06:39,440 --> 02:06:40,240 THANK YOU. 3458 02:06:40,240 --> 02:06:42,160 >> GREAT QUESTION, THANK YOU. 3459 02:06:42,160 --> 02:06:43,920 THANK YOU FOR ASKING. I THINK 3460 02:06:43,920 --> 02:06:45,040 THAT YOU ARE REALLY GETTING TO 3461 02:06:45,040 --> 02:06:47,360 THE HEART OF THE ISSUE HERE, 3462 02:06:47,360 --> 02:06:49,320 WHICH IS THAT WE HAVE 3463 02:06:49,320 --> 02:06:51,320 INTERVENTIONS THAT WE KNOW WORK 3464 02:06:51,320 --> 02:06:53,440 THAT CAN BE HELPFUL FOR 3465 02:06:53,440 --> 02:06:54,440 ADDRESSING STRESS RELATED 3466 02:06:54,440 --> 02:06:55,640 PSYCHOPATHOLOGY AND WHAT WE 3467 02:06:55,640 --> 02:06:57,440 DON'T KNOW IS HOW TO BEST GET 3468 02:06:57,440 --> 02:06:58,480 THOSE INTERVENTIONS INTO THE 3469 02:06:58,480 --> 02:07:00,280 HANDS OF CHILDREN AND FAMILIES 3470 02:07:00,280 --> 02:07:01,880 WHO NEED THEM. T THAT IS REALLY 3471 02:07:01,880 --> 02:07:03,280 A QUESTION OF IMPLEMENTATION 3472 02:07:03,280 --> 02:07:04,920 SCIENCE AND HEALTH SERVICES 3473 02:07:04,920 --> 02:07:07,720 RESEARCH WHICH IS NOT MY AREA OF 3474 02:07:07,720 --> 02:07:09,720 EXPERTISE BUT WHATLY SAY 3475 02:07:09,720 --> 02:07:11,320 ANECDOTALLY ON PREVENTIVE 3476 02:07:11,320 --> 02:07:12,560 INTERVENTIONS WHERE STEPPING 3477 02:07:12,560 --> 02:07:14,600 INTO THAT SPACE WHICH HASN'T 3478 02:07:14,600 --> 02:07:16,560 HISTORICALLY BEEN FOCUS OF OUR 3479 02:07:16,560 --> 02:07:20,000 RESEARCH IS THAT DIGITAL 3480 02:07:20,000 --> 02:07:22,360 INTERVENTIONS EVEN FOR FAMILIES 3481 02:07:22,360 --> 02:07:25,440 WHO EXPERIENCE EXTREME FINANCIAL 3482 02:07:25,440 --> 02:07:26,280 ADORERSTY OR LOW SOCIOECONOMIC 3483 02:07:26,280 --> 02:07:27,440 STATUS ONE CHANGE OVER TEN YEARS 3484 02:07:27,440 --> 02:07:29,040 IS VIRTUALLY EVERYONE WE HAVE 3485 02:07:29,040 --> 02:07:31,680 ENCOUNTERED WE RECRUIT FAMILIES 3486 02:07:31,680 --> 02:07:34,800 THROUGH PEDIATRIC PRIMARY CARE 3487 02:07:34,800 --> 02:07:36,600 OR OTHER CONTEXT, WIDE RANGE OF 3488 02:07:36,600 --> 02:07:38,800 SES. EVERYBODY HAS A SMART 3489 02:07:38,800 --> 02:07:40,280 PHONE, MIGHT NOT HAVE COMPUTER 3490 02:07:40,280 --> 02:07:41,960 AND ACCESS TO INTERNET THROUGH 3491 02:07:41,960 --> 02:07:43,240 BROADBAND AT HOME BUT MOST DO 3492 02:07:43,240 --> 02:07:44,680 HAVE A CELL PHONE AND SOME KIND 3493 02:07:44,680 --> 02:07:46,000 OF PLAN THAT ALLOWS THEM TO 3494 02:07:46,000 --> 02:07:48,040 ACCESS THE INTERNET AND I THINK 3495 02:07:48,040 --> 02:07:49,400 THINKING ABOUT CREATING 3496 02:07:49,400 --> 02:07:51,080 INTERVENTIONS THAT ARE CAPABLE 3497 02:07:51,080 --> 02:07:53,680 OF BEING ADMINISTERED TRUE THE 3498 02:07:53,680 --> 02:07:54,880 SMALL HOE THROUGH THE SMALL 3499 02:07:54,880 --> 02:07:56,640 SCREEN DEVICES PEOPLE DO HAVE 3500 02:07:56,640 --> 02:07:59,280 ACCESS TO AND DON'T TAKE UP 3501 02:07:59,280 --> 02:08:00,640 BANDWIDTH OR PEOPLE HAVE IN 3502 02:08:00,640 --> 02:08:02,440 THEIR MONTHLY PLANS WHAT THEY 3503 02:08:02,440 --> 02:08:05,440 CAN VIEW IS SOMETHING THAT IS 3504 02:08:05,440 --> 02:08:07,720 FEASIBLE I AM NOT THE RIGHT 3505 02:08:07,720 --> 02:08:09,680 PERSON TO THINK HOW A TO DO THAT 3506 02:08:09,680 --> 02:08:11,160 BUT I THINK IT IS POSSIBLE. TO 3507 02:08:11,160 --> 02:08:12,240 THE POINT OF YOUR SECOND 3508 02:08:12,240 --> 02:08:13,120 QUESTION, I DON'T KNOW PROBABLY 3509 02:08:13,120 --> 02:08:13,840 A QUESTION FOR THIS GROUP WHO 3510 02:08:13,840 --> 02:08:15,440 HAS A MUCH BETTER SENSE OF 3511 02:08:15,440 --> 02:08:16,800 LANDSCAPE OF WHAT IS GOING ON IN 3512 02:08:16,800 --> 02:08:17,520 HEALTH SERVICES RESEARCH THAN 3513 02:08:17,520 --> 02:08:19,840 ME. BUT WHAT I WOULD SAY IS THAT 3514 02:08:19,840 --> 02:08:21,680 INVESTING IN THAT KIND OF WORK 3515 02:08:21,680 --> 02:08:23,280 IS PROBABLY GOING TO GIVE 3516 02:08:23,280 --> 02:08:25,360 BIGGEST RETURN ON INVESTMENT FOR 3517 02:08:25,360 --> 02:08:26,320 ADDRESSING THE STRESS RELATED 3518 02:08:26,320 --> 02:08:27,400 MENTAL HEALTH PROBLEMS WE SEE 3519 02:08:27,400 --> 02:08:29,400 RIGHT NOW. AND THE DISPARITIES 3520 02:08:29,400 --> 02:08:31,040 IN THOSE HEALTH PROBLEMS DURING 3521 02:08:31,040 --> 02:08:33,400 THE PANDEMIC. THANK YOU FOR THE 3522 02:08:33,400 --> 02:08:38,040 QUESTION. HOPE I ANSWERED IT. 3523 02:08:38,040 --> 02:08:38,360 SORT OF. 3524 02:08:38,360 --> 02:08:40,520 >> THANK YOU. WE ARE A BIT OVER 3525 02:08:40,520 --> 02:08:41,920 BUT IF THERE IS ANOTHER BURNING 3526 02:08:41,920 --> 02:08:46,120 QUESTION OR TWO FROM THE COUNCIL 3527 02:08:46,120 --> 02:08:49,440 GLAD TO HAVE IT FIELDED. IF 3528 02:08:49,440 --> 02:08:51,160 NOT, THANK YOU VERY MUCH KATIE, 3529 02:08:51,160 --> 02:08:53,240 APPRECIATE YOGINNING US TODAY. 3530 02:08:53,240 --> 02:08:55,600 -- YOU JOINING US AND TELLING US 3531 02:08:55,600 --> 02:08:56,680 ABOUT THIS EXCITING WORK. 3532 02:08:56,680 --> 02:08:57,600 >> THANKS FOR THE INVITATION TO 3533 02:08:57,600 --> 02:09:00,200 BE HERE. CHEERS. 3534 02:09:00,200 --> 02:09:04,440 >> SO NEXT ON THE AGENDA, IS A 3535 02:09:04,440 --> 02:09:07,640 DISCUSSION THAT I WANT TO HAVE 3536 02:09:07,640 --> 02:09:10,320 WITH YOU ALL ABOUT SETTING UP A 3537 02:09:10,320 --> 02:09:11,760 NEW COUNSEL WORK GROUP, ONE THAT 3538 02:09:11,760 --> 02:09:14,960 FOCUSES ON HIGH DIMENSIONAL DATA 3539 02:09:14,960 --> 02:09:17,360 SETSETS. IF I CAN HAVE THE 3540 02:09:17,360 --> 02:09:26,840 PRESENTATION ALEX. 3541 02:09:26,840 --> 02:09:27,920 >> IT IS UP ON MY SCREEN. 3542 02:09:27,920 --> 02:09:30,040 >> MAY NOT HAVE THE RIGHT WINDOW 3543 02:09:30,040 --> 02:09:34,680 SHOWING. HOLD ON A SECOND. NOW 3544 02:09:34,680 --> 02:09:39,360 I CAN SEE IT ON MY BUSY DESKTOP 3545 02:09:39,360 --> 02:09:40,840 SO I GET THIS RIGHT I DID 3546 02:09:40,840 --> 02:09:41,960 SOMETHING UNCHARACTERISTIC FOR 3547 02:09:41,960 --> 02:09:43,760 ME I WROTE OUT WHAT I WANTED TO 3548 02:09:43,760 --> 02:09:48,120 SAY TO Y'ALL. SO MIC A LITTLE 3549 02:09:48,120 --> 02:09:50,400 MORE STILTED THAN MY USUAL 3550 02:09:50,400 --> 02:09:51,240 CONVERSATIONAL TONE BUT I WANT 3551 02:09:51,240 --> 02:09:52,360 THE MAKE SURE TO COVER THINGS 3552 02:09:52,360 --> 02:09:57,320 THE WAY I WANT TO COVER THEM. 3553 02:09:57,320 --> 02:09:59,880 BASIC APPLIED RESEARCH ON HIGH 3554 02:09:59,880 --> 02:10:01,440 DIMENSIONAL PHENOTYPES WHICH 3555 02:10:01,440 --> 02:10:03,760 INCLUDES BUT IS NOT LIMITED TO 3556 02:10:03,760 --> 02:10:06,320 STUDIES TARGETING GENOMICS 3557 02:10:06,320 --> 02:10:09,000 EPIGENOMICS, TRANSCRIPTOMICS 3558 02:10:09,000 --> 02:10:11,960 PROTEOMICS METABOLOMICS, LOTS OF 3559 02:10:11,960 --> 02:10:13,680 OMICS AS WELL AS NEUROIMAGING 3560 02:10:13,680 --> 02:10:14,800 STUDIES AND COMBINATION HAVE 3561 02:10:14,800 --> 02:10:17,760 BEEN INCREASING DRAMATICALLY. IN 3562 02:10:17,760 --> 02:10:20,880 RECENT YEARS. SUCH RESEARCH 3563 02:10:20,880 --> 02:10:22,280 TYPICALLY SEEKS TO IDENTIFY 3564 02:10:22,280 --> 02:10:26,080 MARKERS OF DIAGNOSTIC PROGNOSTIC 3565 02:10:26,080 --> 02:10:27,560 OR THERAPEUTIC VALUE OR TO 3566 02:10:27,560 --> 02:10:29,200 EXAMINE PATHOPHYSIOLOGICAL 3567 02:10:29,200 --> 02:10:30,600 PROCESSES UNDERLYING MENTAL 3568 02:10:30,600 --> 02:10:34,600 ILLNESS. FOR CAMEL, NIMH FUNDED 3569 02:10:34,600 --> 02:10:36,200 NUMEROUS STUDIES SEEKING TO 3570 02:10:36,200 --> 02:10:39,200 EXAMINE EPIGENETIC CHANGES THAT 3571 02:10:39,200 --> 02:10:40,680 HAPPENED AFTER STRESS OR IN 3572 02:10:40,680 --> 02:10:42,240 RESPONSE TO OTHER ENVIRONMENTAL 3573 02:10:42,240 --> 02:10:44,920 RISK FACTORS, SEEKING TO LINK 3574 02:10:44,920 --> 02:10:47,400 THOSE EPIGENETIC CHANGES TO 3575 02:10:47,400 --> 02:10:50,480 DOWNSTREAM BEHAVIORAL EFFECTS. 3576 02:10:50,480 --> 02:10:52,400 THE COMPLEXITY AND SIZE OF THESE 3577 02:10:52,400 --> 02:10:54,880 DATA SETS AND THE RELATIVE 3578 02:10:54,880 --> 02:10:56,480 NOVELTY OF STATISTICAL MACHINE 3579 02:10:56,480 --> 02:10:58,520 LEARNING APPROACH USED TO 3580 02:10:58,520 --> 02:11:01,080 ANALYZE THEM, HAVE LED TO 3581 02:11:01,080 --> 02:11:01,640 CONCERNS REGARDING RIGOR AND 3582 02:11:01,640 --> 02:11:05,400 REPRODUCIBILITY. FOR EXAMPLE, 3583 02:11:05,400 --> 02:11:09,560 THIS PAPER I HAVE HERE ON THE 3584 02:11:09,560 --> 02:11:11,400 SLIDE REPRODUCIBLE BRAIN WIDE 3585 02:11:11,400 --> 02:11:11,960 ASSOCIATION STUDIES REQUIRE 3586 02:11:11,960 --> 02:11:16,800 THOUSANDS OF INDIVIDUALS, IS ONE 3587 02:11:16,800 --> 02:11:19,440 THAT COMES OUT OF RESEARCH WE 3588 02:11:19,440 --> 02:11:20,880 SUPPORT BUD THAT DEMONSTRATES 3589 02:11:20,880 --> 02:11:23,880 THROUGH USE OF LARGE SCALE 3590 02:11:23,880 --> 02:11:27,480 NEUROIMAGING DATA SETS THAT 3591 02:11:27,480 --> 02:11:29,000 REPRODUCIBILITY FINDINGS ARE 3592 02:11:29,000 --> 02:11:31,520 CHALLENGING AND REQUIRE FROM THE 3593 02:11:31,520 --> 02:11:33,920 TITLE THOUSANDS OF INDIVIDUALS. 3594 02:11:33,920 --> 02:11:36,440 THIS IS NOT THE ONLY PAPER OF 3595 02:11:36,440 --> 02:11:39,720 ITS KIND. IN FACT SEVEN YEARS 3596 02:11:39,720 --> 02:11:41,640 AGO, THESE INVESTIGATORS 3597 02:11:41,640 --> 02:11:45,000 PUBLISHED A PAPER ON THE 3598 02:11:45,000 --> 02:11:46,120 VARIABLE REPRODUCIBILITY IN 3599 02:11:46,120 --> 02:11:48,680 GENOMICS SCALE PUBLIC DATA USING 3600 02:11:48,680 --> 02:11:51,040 ANOTHER RESOURCE THAT NIMH 3601 02:11:51,040 --> 02:11:54,160 HELPED DEVELOP, THE ENCODE CHIP 3602 02:11:54,160 --> 02:11:59,440 SEQUENCING RESOURCE. ENCODE IS 3603 02:11:59,440 --> 02:12:02,640 THE CHIP CHROMOSOME 3604 02:12:02,640 --> 02:12:05,720 IMMUNOPRECIPITATION STUDY IS AN 3605 02:12:05,720 --> 02:12:07,920 EPIGENETIC MARKER SCATTERED 3606 02:12:07,920 --> 02:12:09,720 THROUGHOUT THE GENOME THAT IS 3607 02:12:09,720 --> 02:12:10,800 SIMILARLY HIGH DIMENSIONAL IN 3608 02:12:10,800 --> 02:12:11,920 TERMS OF DATA THAT CAN BE 3609 02:12:11,920 --> 02:12:15,680 DERIVED IN THIS PAPER DESCRIBED 3610 02:12:15,680 --> 02:12:17,120 THE CHALLENGES AND SAMPLE SIZES 3611 02:12:17,120 --> 02:12:19,640 NECESSARY TO ACHIEVE REASONABLE 3612 02:12:19,640 --> 02:12:20,880 LEVELS OF REPRODUCIBILITY IN 3613 02:12:20,880 --> 02:12:26,520 THAT DATA SET AS WELL. 3614 02:12:26,520 --> 02:12:27,840 MEANWHILE COSTS ARE ASSOCIATED 3615 02:12:27,840 --> 02:12:29,160 WITH ACQUIRING THESE DATA 3616 02:12:29,160 --> 02:12:33,120 MAINTAINING THESE DATA, AND 3617 02:12:33,120 --> 02:12:37,920 FUNDING THE RESEARCH TO CONNECT 3618 02:12:37,920 --> 02:12:39,560 THOSE DATA TO MENTAL HEALTH 3619 02:12:39,560 --> 02:12:42,200 RELEVANT PHENOTYPES, CONTINUE TO 3620 02:12:42,200 --> 02:12:47,320 INCREASE DRAMATICALLY AS WELL. 3621 02:12:47,320 --> 02:12:49,160 NIMH NEEDS TO DEFINE PRIORITIES 3622 02:12:49,160 --> 02:12:53,120 AND APPROACHES THAT WILL ENSURE 3623 02:12:53,120 --> 02:12:54,280 RIGOR AND REPRODUCIBILITY WHILE 3624 02:12:54,280 --> 02:12:55,720 ALSO ENABLING FISCAL 3625 02:12:55,720 --> 02:12:59,760 RESPONSIBILITY. PROGRESS IN THE 3626 02:12:59,760 --> 02:13:04,040 FIELD OF GENOMICS PROVIDES AN 3627 02:13:04,040 --> 02:13:05,680 EXAMPLE HOW NIMH SUCCESSFULLY 3628 02:13:05,680 --> 02:13:09,000 NAVIGATED SIMILAR ISSUES IN THE 3629 02:13:09,000 --> 02:13:12,760 STUDY OF GENOMICS BUT LEADING 3630 02:13:12,760 --> 02:13:14,200 EXTRAMURAL INVESTIGATORS AND 3631 02:13:14,200 --> 02:13:19,440 SEEKING HELP AND ADVICE FROM 3632 02:13:19,440 --> 02:13:22,560 THIS COUNCIL. THIS EFFORT, WORK 3633 02:13:22,560 --> 02:13:24,880 GROUP GENOMICS WORK GROUP OF THE 3634 02:13:24,880 --> 02:13:27,400 NATIONAL ADVISORY MENTAL HEALTH 3635 02:13:27,400 --> 02:13:29,000 COUNSEL CULMINATED IN SERIES OF 3636 02:13:29,000 --> 02:13:30,400 RECOMMENDATIONS MEANT TO DEFINE 3637 02:13:30,400 --> 02:13:31,400 RIGOROUS PRIORITIES AN 3638 02:13:31,400 --> 02:13:34,560 APPROACHES IN THE ACQUISITION 3639 02:13:34,560 --> 02:13:35,760 ANALYSIS AND INTERPRETATION OF 3640 02:13:35,760 --> 02:13:37,080 GENETIC FINDINGS AND THEIR 3641 02:13:37,080 --> 02:13:39,080 APPLICATION TO SUBSEQUENT 3642 02:13:39,080 --> 02:13:40,400 BIOLOGICAL AND CLINICAL 3643 02:13:40,400 --> 02:13:45,200 INQUIRIES. NIMH FUNDED GENOMICS 3644 02:13:45,200 --> 02:13:46,520 VERGE HAS RESULTED AS WE 3645 02:13:46,520 --> 02:13:49,320 DISCUSSED EARLIER IN UPDATE IN 3646 02:13:49,320 --> 02:13:49,960 SUCCESSFUL IDE PCATION OF 3647 02:13:49,960 --> 02:13:51,560 NUMEROUS COMMON AND RARE 3648 02:13:51,560 --> 02:13:55,440 VARIANTS ROBUSTLY IMPLICATED IN 3649 02:13:55,440 --> 02:13:56,560 NEURAL DEVELOPMENTAL AND 3650 02:13:56,560 --> 02:13:58,760 PSYCHIATRIC DISORDERS. IN THE 3651 02:13:58,760 --> 02:14:00,800 2018 REPORT FROM NATIONAL 3652 02:14:00,800 --> 02:14:01,760 ADVISORY MENTAL HEALTH COUNCIL 3653 02:14:01,760 --> 02:14:03,360 WORK GROUP ON GENOMICS IS BUILT 3654 02:14:03,360 --> 02:14:05,800 ON THAT SUCCESS, BASED ON THE 3655 02:14:05,800 --> 02:14:07,760 RECOMMENDATIONS FROM THAT 3656 02:14:07,760 --> 02:14:11,760 REPORT, THE NIMH HAS PROMULGATE 3657 02:14:11,760 --> 02:14:14,440 AND ACTED UPON GUIDANCE THAT 3658 02:14:14,440 --> 02:14:15,160 CLARIFIES TO THE FIELD STRENGTHS 3659 02:14:15,160 --> 02:14:15,800 OF REQUIRED EVIDENCE FOR GENERAL 3660 02:14:15,800 --> 02:14:17,680 IT CAN ASSOCIATION PRIORITIES 3661 02:14:17,680 --> 02:14:22,040 FOR FUTURE STUDIES OF GENETIC 3662 02:14:22,040 --> 02:14:23,720 LINKAGE AND ACCEPTABLE DESIGNS 3663 02:14:23,720 --> 02:14:26,720 AND APPROACHES FOR BIOLOGICAL 3664 02:14:26,720 --> 02:14:28,480 AND CLINICAL STUDY THAT SEEK TO 3665 02:14:28,480 --> 02:14:32,040 BUILD UPON THESE FINDINGS. BY 3666 02:14:32,040 --> 02:14:32,960 CONTRAST, THERE HAS BEEN LINTED 3667 02:14:32,960 --> 02:14:35,760 SUCCESS IN GENERATING 3668 02:14:35,760 --> 02:14:36,800 REPRODUCIBLE FINDINGS FROM 3669 02:14:36,800 --> 02:14:40,640 STUDIES THAT USE EPIGENETICS, 3670 02:14:40,640 --> 02:14:43,200 OTHER OMICS NEURAL IMAGING AND 3671 02:14:43,200 --> 02:14:45,360 SIMILARLY COMPLEX HIGH 3672 02:14:45,360 --> 02:14:47,760 DIMENSIONAL DATA SETS. THERE 3673 02:14:47,760 --> 02:14:48,720 MAYBE SEVERAL REASONS FOR THIS 3674 02:14:48,720 --> 02:14:52,520 FAILURE. ONE PARTICULAR 3675 02:14:52,520 --> 02:14:55,280 CHALLENGE WITH THIS NEW CROP OF 3676 02:14:55,280 --> 02:14:56,480 HIGH DIMENSIONAL DATA SETS, 3677 02:14:56,480 --> 02:14:58,720 THESE DATA SETS THAT USE THINGS 3678 02:14:58,720 --> 02:15:01,080 LIKE GENE EXPRESSION MICROBIOME 3679 02:15:01,080 --> 02:15:02,840 COMPOSITION OR WHOLE BRAIN 3680 02:15:02,840 --> 02:15:06,000 NEURAL ACTIVITY ARE DYNAMICALLY 3681 02:15:06,000 --> 02:15:09,480 REGULATED AND CONTEXT DEPENDENT. 3682 02:15:09,480 --> 02:15:12,040 UNLIKE THE GENOME A SINGLE SNAP 3683 02:15:12,040 --> 02:15:15,680 SHOT OF THE EPIGENOME OR WHOLE 3684 02:15:15,680 --> 02:15:16,880 BRAIN NEURAL ACTIVITY DOESN'T 3685 02:15:16,880 --> 02:15:18,480 CAPTURE OR MAY NOT CAPTURE A 3686 02:15:18,480 --> 02:15:20,800 RELIABLE PICTURE OF A DISEASE 3687 02:15:20,800 --> 02:15:23,880 STATE OR A BEHAVIOR OR THE 3688 02:15:23,880 --> 02:15:28,320 UNDERLYING PATHOBIOLOGY OR 3689 02:15:28,320 --> 02:15:29,800 PHYSIOLOGY. A SECOND ISSUE IS 3690 02:15:29,800 --> 02:15:31,480 THE FIELD SEEMS NOT TO HAVE 3691 02:15:31,480 --> 02:15:33,360 ARRIVED UPON A STANDARDIZED 3692 02:15:33,360 --> 02:15:36,240 FRAMEWORK FOR EXPERIMENTAL 3693 02:15:36,240 --> 02:15:37,320 DESIGN AND STATISTICAL 3694 02:15:37,320 --> 02:15:39,000 INFERENCE. LEADING TO THE 3695 02:15:39,000 --> 02:15:40,560 PERSISTENCE OF CONFOUNDING 3696 02:15:40,560 --> 02:15:45,200 EFFECTS, AND DIFFICULTIES IN 3697 02:15:45,200 --> 02:15:47,520 INTERPRETING THE RELIABILITY AND 3698 02:15:47,520 --> 02:15:48,800 SIGNIFICANCE OF FINDINGS. 3699 02:15:48,800 --> 02:15:49,880 FINALLY, MANY OF THESE 3700 02:15:49,880 --> 02:15:52,520 FUNCTIONAL STUDIES OF HIGH 3701 02:15:52,520 --> 02:15:53,720 DIMENSIONAL PHENOTYPES ARE 3702 02:15:53,720 --> 02:15:55,200 FURTHER LIMITED BY LACK OF 3703 02:15:55,200 --> 02:15:57,200 COHERENT CONCEPTUAL FRAMEWORK 3704 02:15:57,200 --> 02:15:58,640 FOR UNDERSTANDING THE 3705 02:15:58,640 --> 02:16:01,200 RELATIONSHIP BETWEEN MOLECULAR, 3706 02:16:01,200 --> 02:16:06,840 NEURAL AND BEHAVIORAL VARIATION. 3707 02:16:06,840 --> 02:16:10,880 NIMH IS THEREFORE SEEKING 3708 02:16:10,880 --> 02:16:13,240 ADVISORY INPUT FROM THE NAMHC 3709 02:16:13,240 --> 02:16:14,760 THROUGH CONVENING AD HOC COUNCIL 3710 02:16:14,760 --> 02:16:17,200 WORK GROUP ON HIGH DIMENSIONAL 3711 02:16:17,200 --> 02:16:19,640 DATA SETS. THE PURPOSE IS FOR 3712 02:16:19,640 --> 02:16:21,920 THIS GROUP TO DEVELOP 3713 02:16:21,920 --> 02:16:23,760 RECOMMENDATIONS REGARDING 3714 02:16:23,760 --> 02:16:25,760 APPROPRIATE CONCEPTUAL FRAME 3715 02:16:25,760 --> 02:16:28,040 WORKS AND EXPERIENCAL ANALYTIC 3716 02:16:28,040 --> 02:16:29,760 DESIGNS FOR EXPERIMENTS THAT USE 3717 02:16:29,760 --> 02:16:32,800 OR GATHER HIGH DIMENSIONAL DATA 3718 02:16:32,800 --> 02:16:35,080 SETS. POTENTIAL AREAS FOR 3719 02:16:35,080 --> 02:16:36,800 CONSIDERATION BY THE WORK GROUP 3720 02:16:36,800 --> 02:16:38,800 INCLUDE, ONE, ENSURING 3721 02:16:38,800 --> 02:16:40,120 STATISTICAL RIGOR AND ENHANCING 3722 02:16:40,120 --> 02:16:43,760 REPRODUCIBILITY. QUESTIONS THAT 3723 02:16:43,760 --> 02:16:45,640 WORK GROUP MIGHT ASK ARE INCLUDE 3724 02:16:45,640 --> 02:16:47,480 ARE THERE PROVEN APPROACHES OR 3725 02:16:47,480 --> 02:16:48,480 EXPERIMENTAL DESIGNS THAT CAN BE 3726 02:16:48,480 --> 02:16:51,640 USED TO MAXIMIZE OR VERIFY THE 3727 02:16:51,640 --> 02:16:54,040 STATISTICAL RIGOR OF FINDINGS 3728 02:16:54,040 --> 02:16:56,320 FROM THESE DATA SETS. CAN WE 3729 02:16:56,320 --> 02:16:57,800 DEFINE HIERARCHY OF APPROACHES 3730 02:16:57,800 --> 02:17:00,400 FOR ENSURING REPRODUCIBILITY. 3731 02:17:00,400 --> 02:17:02,400 FOR EXAMPLE WITH MACHINE 3732 02:17:02,400 --> 02:17:04,920 LEARNING APPROACHES REPEATED 3733 02:17:04,920 --> 02:17:08,640 LEAVE ONE OUT STUDIES VERSUS 3734 02:17:08,640 --> 02:17:09,240 REPRODUCING INDEPENDENT DATA 3735 02:17:09,240 --> 02:17:11,400 SETS APPROACHES, IS ONE BETTER 3736 02:17:11,400 --> 02:17:13,600 THAN THE OTHER AND CAN WE 3737 02:17:13,600 --> 02:17:16,600 RECOMMEND SUCH HIERARCHY. THIRD, 3738 02:17:16,600 --> 02:17:17,640 A QUESTION IN THIS AREA WOULD 3739 02:17:17,640 --> 02:17:19,640 INCLUDE WHAT ARE THE SAFE GUARDS 3740 02:17:19,640 --> 02:17:21,040 NECESSARY WHEN USING DIMENSION 3741 02:17:21,040 --> 02:17:22,960 REDUCTION TECHNIQUES CLUSTERING 3742 02:17:22,960 --> 02:17:24,840 OR OTHER DATA DRIVEN APPROACHES 3743 02:17:24,840 --> 02:17:28,200 TO REDUCE COMPLEXITY TO ENSURE 3744 02:17:28,200 --> 02:17:31,560 THAT THEY ARE NONETHELESS ROBUST 3745 02:17:31,560 --> 02:17:33,640 AND REPRODUCIBLE. THE SECOND 3746 02:17:33,640 --> 02:17:35,040 AREA OF CONSIDERATION IS IN THE 3747 02:17:35,040 --> 02:17:35,760 UNDERSTANDING -- IN 3748 02:17:35,760 --> 02:17:38,280 UNDERSTANDING THE ROLE OF 3749 02:17:38,280 --> 02:17:39,720 HYPOTHESIS AND CONCEPTUAL FRAME 3750 02:17:39,720 --> 02:17:42,080 WORKS IN THE DESIGN OF THESE 3751 02:17:42,080 --> 02:17:44,360 STUDIES. WHAT IS THE ROLE OF 3752 02:17:44,360 --> 02:17:47,080 HYPOTHESIS BASED VERSUS DATA 3753 02:17:47,080 --> 02:17:51,400 DRIVEN STUDIES IN THE CONDUCT OF 3754 02:17:51,400 --> 02:17:53,040 RESEARCH ON HIGH DIMENSIONAL 3755 02:17:53,040 --> 02:17:55,400 DATA SETS? SHOULD WE USE 3756 02:17:55,400 --> 02:17:58,880 DIFFERENT LEVELS OF SURETY WHEN 3757 02:17:58,880 --> 02:18:00,840 WE DESIGN SUCH EXPERIMENTS? WHAT 3758 02:18:00,840 --> 02:18:02,560 ARE THE DIFFERENT DESIGN 3759 02:18:02,560 --> 02:18:05,320 EXPERIMENTS THAT APPLY TO 3760 02:18:05,320 --> 02:18:06,520 HYPOTHESIS BASED VERSUS DATA 3761 02:18:06,520 --> 02:18:11,080 DRIVEN APPROAC APPROACHES? AND S 3762 02:18:11,080 --> 02:18:11,960 ACCEPTABLE LEVEL OF EVIDENCE 3763 02:18:11,960 --> 02:18:14,200 USING HYPOTHESES TO REDUCE 3764 02:18:14,200 --> 02:18:15,720 DIMENSIONALITY OR COMPLEXITY OF 3765 02:18:15,720 --> 02:18:18,400 THE DATA SETS BEING CONSIDERED? 3766 02:18:18,400 --> 02:18:20,520 THE THIRD AREA OF CONSIDERATION 3767 02:18:20,520 --> 02:18:22,680 ARE STUDIES INVOLVING PERIPHERAL 3768 02:18:22,680 --> 02:18:26,440 BIOMARKERS. DOES QUESTIONS GROUP 3769 02:18:26,440 --> 02:18:28,640 MIGHT ASK INCLUDE DOES THE 3770 02:18:28,640 --> 02:18:30,200 AVAILABILITY OF OMICS AND OTHER 3771 02:18:30,200 --> 02:18:31,840 HIGH DIMENSIONAL APPROACHES 3772 02:18:31,840 --> 02:18:34,440 ALONE OR IN COMBINATION INCREASE 3773 02:18:34,440 --> 02:18:37,480 THE POTENTIAL CLINICAL OR 3774 02:18:37,480 --> 02:18:38,680 SCIENTIFIC EWE UNTIL/OF 3775 02:18:38,680 --> 02:18:41,840 PERIPHERAL BIOMARKERS? OR SHOULD 3776 02:18:41,840 --> 02:18:44,120 NIMH CONTINUE TO DISCOURAGE 3777 02:18:44,120 --> 02:18:47,040 PERIPHERAL BIOMARKER STUDIES? 3778 02:18:47,040 --> 02:18:48,560 WHAT APPROACHES OR DESIGNS MIGHT 3779 02:18:48,560 --> 02:18:50,120 BE USED TO JUSTIFY OR ENHANCE 3780 02:18:50,120 --> 02:18:51,960 THE POTENTIAL RELEVANCE OF 3781 02:18:51,960 --> 02:18:53,280 EXPERIMENTS THAT UTILIZE 3782 02:18:53,280 --> 02:18:56,600 PERIPHERAL BIOMARKER DATA? AND 3783 02:18:56,600 --> 02:19:00,200 HOF MIGHT PERIPHERAL AND CENTRAL 3784 02:19:00,200 --> 02:19:02,080 HIGH DIMENSIONAL MEASURES BE 3785 02:19:02,080 --> 02:19:03,680 EVALUATED FOR PREDICTIVE OR 3786 02:19:03,680 --> 02:19:05,560 MECHANISTIC RELEVANCE? FINAL 3787 02:19:05,560 --> 02:19:07,080 AREA OF CONSIDERATION INCLUDES 3788 02:19:07,080 --> 02:19:09,240 STUDIES OF POTENTIAL CLINICAL 3789 02:19:09,240 --> 02:19:11,760 UTILITY. TO WHAT EXTENT HIGH 3790 02:19:11,760 --> 02:19:13,080 DIMENSIONAL MEASURES BE OF 3791 02:19:13,080 --> 02:19:14,800 CLINICAL VALUE IN PSYCHIATRY, 3792 02:19:14,800 --> 02:19:16,880 WHETHER IT BE PREDICTIVE 3793 02:19:16,880 --> 02:19:18,600 DIAGNOSTIC THERAPEUTIC OR 3794 02:19:18,600 --> 02:19:20,360 PROGNOSTIC. ARE THERE DESIGN 3795 02:19:20,360 --> 02:19:21,720 DIFFERENCES THAT WOULD BE 3796 02:19:21,720 --> 02:19:24,280 APPROPRIATE FOR STUDIES AIMED AT 3797 02:19:24,280 --> 02:19:25,960 CLINICAL UTILITY AS OPPOSE TO 3798 02:19:25,960 --> 02:19:28,560 THOSE AIMED AT UNDERSTANDING 3799 02:19:28,560 --> 02:19:31,480 DISEASE MECHANISMS. I WILL 3800 02:19:31,480 --> 02:19:35,000 MENTION THESE QUESTIONS AND THIS 3801 02:19:35,000 --> 02:19:36,200 DRAFT CHARGE ARE MY FIRST 3802 02:19:36,200 --> 02:19:38,160 ATTEMPT TO DEFINE THE PROBLEM 3803 02:19:38,160 --> 02:19:39,440 AND THEN I WOULD LOOK FORWARD TO 3804 02:19:39,440 --> 02:19:41,800 INPUT FROM THE WORK GROUP, OTHER 3805 02:19:41,800 --> 02:19:44,840 AREAS OF DISCUSSION OR 3806 02:19:44,840 --> 02:19:52,160 CONSIDERATION. SO I FRAMED THE 3807 02:19:52,160 --> 02:19:53,720 WORK GROUP REALM OF 3808 02:19:53,720 --> 02:19:55,720 RESPONSIBILITY OR CHARGE FOR 3809 02:19:55,720 --> 02:19:58,800 YOU. I WANT TO GIVE YOU A SENSE 3810 02:19:58,800 --> 02:20:00,440 OF THE TIME LINE WE ARE HOPING 3811 02:20:00,440 --> 02:20:01,960 FOR THEN ASK FOR VOLUNTEERS WHO 3812 02:20:01,960 --> 02:20:03,120 MIGHT BE INTERESTED IN 3813 02:20:03,120 --> 02:20:03,920 PARTICIPATING IN THE THIS WORK 3814 02:20:03,920 --> 02:20:07,800 GROUP. THE NIMH IS AIMING FOR 3815 02:20:07,800 --> 02:20:10,080 SERIES OF VIRTUAL MEETINGS THAT 3816 02:20:10,080 --> 02:20:12,960 WOULD TAKE PLACE BETWEEN NOW AND 3817 02:20:12,960 --> 02:20:18,120 THE WINTER, EARLY -- OF EARLY 3818 02:20:18,120 --> 02:20:21,360 2023. WITH THE BASIC FRAMEWORK 3819 02:20:21,360 --> 02:20:22,600 FOR RECOMMENDATIONS TO BE 3820 02:20:22,600 --> 02:20:24,480 PRESENTED AT THE MAY 2023 3821 02:20:24,480 --> 02:20:25,920 MEETING, PERHAPS IN THE FORM OF 3822 02:20:25,920 --> 02:20:28,520 A FINALIZED REPORT OR A FINAL 3823 02:20:28,520 --> 02:20:30,000 REPORT COULD BE DELIVERED 3824 02:20:30,000 --> 02:20:32,320 SHORTLY AFTER THAT MAY MEETING. 3825 02:20:32,320 --> 02:20:35,240 WE HAVE IDENTIFIED NIMH PROGRAM 3826 02:20:35,240 --> 02:20:38,280 STAFF LEADS WHICH INCLUDE 3827 02:20:38,280 --> 02:20:44,160 JONATHAN PEVSNER AND GEETHA 3828 02:20:44,160 --> 02:20:46,640 SENTHIL CO-LEADS OF THE TEAM AT 3829 02:20:46,640 --> 02:20:48,880 NIMH. OTHER PROGRAM STAFF WITH 3830 02:20:48,880 --> 02:20:50,920 EXPERTISE IN OTHER ASPECTS OF 3831 02:20:50,920 --> 02:20:51,840 HIGH DIMENSIONAL AN DATA SET 3832 02:20:51,840 --> 02:20:54,840 RESEARCH. WE ARE LOOKING FOR 3833 02:20:54,840 --> 02:20:56,280 VOLUNTEERS FROM COUNCIL AND IN 3834 02:20:56,280 --> 02:20:58,920 PARTICULAR, WE ARE LOOKING FOR 3835 02:20:58,920 --> 02:21:00,840 VOLUNTEER FOR A WORK GROUP 3836 02:21:00,840 --> 02:21:02,320 CO-LEAD, WE ANTICIPATE HAVING 3837 02:21:02,320 --> 02:21:04,520 TWO LEADS FOR THE WORK GROUP, 3838 02:21:04,520 --> 02:21:05,800 ONE COUNCIL MEMBER AND ONE 3839 02:21:05,800 --> 02:21:07,960 MEMBER OF THE EXTRAMURAL 3840 02:21:07,960 --> 02:21:10,240 COMMUNITY. WE ANTICIPATE WORK 3841 02:21:10,240 --> 02:21:13,680 GROUP SIZE OF 10 TO 15 3842 02:21:13,680 --> 02:21:16,400 EXTRAMURAL AND COUNCIL PEOPLE TO 3843 02:21:16,400 --> 02:21:18,920 BE COMPLIMENTED BY A SLIGHTLY 3844 02:21:18,920 --> 02:21:20,880 SMALLER GROUP OF NIMH STAFF TO 3845 02:21:20,880 --> 02:21:23,840 HELP THEM OUT. THE 3846 02:21:23,840 --> 02:21:26,640 RESPONSIBILITY OF DRAFTING THE 3847 02:21:26,640 --> 02:21:31,680 REPORT WILL FALL ON NIMH STAFF 3848 02:21:31,680 --> 02:21:35,520 WITH HEAVY GUIDANCE AND THOROUGH 3849 02:21:35,520 --> 02:21:39,240 EDITING BY THE TEAM OF -- BY THE 3850 02:21:39,240 --> 02:21:40,720 WORK GROUP MEMBERS AND WORK 3851 02:21:40,720 --> 02:21:43,200 GROUP CHAIRS AND IF NECESSARY WE 3852 02:21:43,200 --> 02:21:44,760 CAN ALSO CONTRACT FOR SCIENCE 3853 02:21:44,760 --> 02:21:45,920 WRITER TO HELP WITH THAT AS 3854 02:21:45,920 --> 02:21:51,560 WELL. SO THAT IS THE CONTEXT OF 3855 02:21:51,560 --> 02:21:53,160 THE WORK GROUP, THE CONTENT WE 3856 02:21:53,160 --> 02:21:54,680 HOPE THAT THE WORK GROUP WILL 3857 02:21:54,680 --> 02:21:56,600 WORK ON AND THE PROCESS FOR THE 3858 02:21:56,600 --> 02:21:59,280 WORK GROUP. I'M OPEN TO 3859 02:21:59,280 --> 02:22:04,080 QUESTIONS, COMMENTS, VOLUNT 3860 02:22:04,080 --> 02:22:08,520 VOLUNTEERING NOW. YOU CAN NOW 3861 02:22:08,520 --> 02:22:10,520 CLOSE THE SLIDES DOWN, ALEX. 3862 02:22:10,520 --> 02:22:20,640 THANKS. 3863 02:22:22,280 --> 02:22:24,480 >> ALL RIGHT. THERE IS -- 3864 02:22:24,480 --> 02:22:28,160 >> LOOKS LIKE JOSEPH HAS HIS 3865 02:22:28,160 --> 02:22:30,040 HAND UP. 3866 02:22:30,040 --> 02:22:33,240 >> JOSEPH, G GO AHEAD. JOEL AS 3867 02:22:33,240 --> 02:22:33,440 WELL. 3868 02:22:33,440 --> 02:22:35,360 >> SO THANK YOU FOR THAT. SO I 3869 02:22:35,360 --> 02:22:36,720 HAVE A COUPLE OF QUESTIONS, 3870 02:22:36,720 --> 02:22:41,920 WHENEVER WE LOOK AT THIS JUST A 3871 02:22:41,920 --> 02:22:43,120 POINT OF INFORMATION 3872 02:22:43,120 --> 02:22:44,080 CLARIFICATION. WHEN YOU -- WHAT 3873 02:22:44,080 --> 02:22:47,320 YOU ARE SUGGESTING IS THAT IT 3874 02:22:47,320 --> 02:22:50,360 MOSTLY BASIC SCIENCE THAT YOU 3875 02:22:50,360 --> 02:22:52,240 ARE LOOKING FOR YOU REPORT ON OR 3876 02:22:52,240 --> 02:22:54,200 ARE YOU LOOKING FOR SOMETHING 3877 02:22:54,200 --> 02:22:55,360 BROADER? PARTICULARLY SINCE YOU 3878 02:22:55,360 --> 02:22:58,640 ARE TALKING ABOUT CLINICAL 3879 02:22:58,640 --> 02:22:59,920 UTILITY, WHICH IS MY FIRST 3880 02:22:59,920 --> 02:23:03,240 QUESTION, MY SECOND QUESTION, 3881 02:23:03,240 --> 02:23:07,360 ARE YOU ALSO LOOKING AT 3882 02:23:07,360 --> 02:23:10,760 POTENTIAL FOR POPULATION 3883 02:23:10,760 --> 02:23:12,120 APPLICATION? THERE ARE A NUMBER 3884 02:23:12,120 --> 02:23:15,760 OF POPULATIONS MOSTRY SMALL 3885 02:23:15,760 --> 02:23:17,400 POPULATIONS BECAUSE OF THAT, -- 3886 02:23:17,400 --> 02:23:18,720 MOSTLY SMALL POPULATION WHOSE 3887 02:23:18,720 --> 02:23:20,920 HAVE GENETIC DISORDERS THAT 3888 02:23:20,920 --> 02:23:22,160 THEMSELVES THAT HAVE A LOT OF 3889 02:23:22,160 --> 02:23:24,520 THESE EXPERIENCES THAT INFLUENCE 3890 02:23:24,520 --> 02:23:25,560 WHAT IT IS YOU ARE TALKING 3891 02:23:25,560 --> 02:23:30,200 ABOUT. AND SO IT IS SORT OF A 3892 02:23:30,200 --> 02:23:32,080 CONTINGENT QUESTION. IF IT IS 3893 02:23:32,080 --> 02:23:34,080 OUTSIDE THE LAB ARE THEY BEING 3894 02:23:34,080 --> 02:23:36,120 CONSIDERED AND IF -- BUT IF 3895 02:23:36,120 --> 02:23:37,040 INSIDE THE LAB THAT IS A 3896 02:23:37,040 --> 02:23:39,960 DIFFERENT STORY. SO THAT IS A 3897 02:23:39,960 --> 02:23:41,440 STARTING POINT AS A QUESTION, 3898 02:23:41,440 --> 02:23:42,120 THANK YOU. 3899 02:23:42,120 --> 02:23:45,040 >> SO THANKS, JOSEPH. THE VAST 3900 02:23:45,040 --> 02:23:46,680 MAJORITY OF THE EXPERIMENTS THAT 3901 02:23:46,680 --> 02:23:48,040 USE HIGH DIMENSIONAL DITSIEST 3902 02:23:48,040 --> 02:23:50,800 ARE TAKING PLACE IN HUMANS AND 3903 02:23:50,800 --> 02:23:53,600 MOST OF THEM USE A MIXTURE OF 3904 02:23:53,600 --> 02:23:56,080 CLINICAL POPULATIONS AND COHORT 3905 02:23:56,080 --> 02:23:57,720 DATA, SOME OF THESE KINDS OF 3906 02:23:57,720 --> 02:23:59,560 THINGS ARE FOR EXAMPLE, 3907 02:23:59,560 --> 02:24:03,760 EPIGENETIC MARKERS ON POSTMORTEM 3908 02:24:03,760 --> 02:24:07,520 BRAIN TISSUE, OR IN BLOOD TAKEN 3909 02:24:07,520 --> 02:24:10,000 FROM PATIENTS. OF COURSE NEURAL 3910 02:24:10,000 --> 02:24:12,680 IMAGING IS TYPICALLY COHORTS OR 3911 02:24:12,680 --> 02:24:13,960 GROUPS OF PATIENTS. SO MOST OF 3912 02:24:13,960 --> 02:24:15,800 THIS IN HUMANS, MOST OF THE DATA 3913 02:24:15,800 --> 02:24:17,720 COMES FROM HUMANS THOUGH 3914 02:24:17,720 --> 02:24:18,880 CERTAINLY QUESTIONS DEALING WITH 3915 02:24:18,880 --> 02:24:21,520 LARGE SIZE DATA SETS, HIGH 3916 02:24:21,520 --> 02:24:22,320 DIMENSIONAL DATA THAT ARE HE 3917 02:24:22,320 --> 02:24:24,080 WILL EVENTUAL FOR ANIMALS. -- 3918 02:24:24,080 --> 02:24:26,120 RELEVANT FOR ANIMALS. THE WORK 3919 02:24:26,120 --> 02:24:27,760 IS BOTH MECHANISTIC AND ALSO 3920 02:24:27,760 --> 02:24:30,480 CLINICAL. SO THERE ARE LOTS OF 3921 02:24:30,480 --> 02:24:36,200 PEOPLE WHO ARE USING DRIVEN 3922 02:24:36,200 --> 02:24:38,600 APPROACHES ON LARGE TO TRY TO 3923 02:24:38,600 --> 02:24:41,760 ASK THOSE WHETHER THOSE FINDINGS 3924 02:24:41,760 --> 02:24:43,120 THEY CAN FIND PREDICT RESPONSE 3925 02:24:43,120 --> 02:24:45,400 TO A GIVEN MEDICATION. WE THINK 3926 02:24:45,400 --> 02:24:47,600 BIOMARKER APPROACH WOULD BE 3927 02:24:47,600 --> 02:24:49,960 VALUABLE. BUT QUITE FAMOUSLY 3928 02:24:49,960 --> 02:24:52,840 EXAMPLES EVEN EXAMPLES THAT I 3929 02:24:52,840 --> 02:24:54,120 HAVE TOUTED HERE, IN FRONT OF 3930 02:24:54,120 --> 02:24:55,480 THIS GROUP IN SCIENCE UPDATES 3931 02:24:55,480 --> 02:24:57,840 HAVE HAD CHALLENGES IN TERMS OF 3932 02:24:57,840 --> 02:25:01,920 REPLICATING THE FINDINGS. SO 3933 02:25:01,920 --> 02:25:03,320 ANOTHER EXAMPLE OF THE THIS SORT 3934 02:25:03,320 --> 02:25:05,800 OF WORK I GAVE DURING THE 3935 02:25:05,800 --> 02:25:06,920 INTRODUCTION JUST CLARIFY THERE, 3936 02:25:06,920 --> 02:25:09,760 IS A LOT OF PEOPLE LOOKING AT 3937 02:25:09,760 --> 02:25:11,360 EPIGENETIC MARKS WHETHER IN 3938 02:25:11,360 --> 02:25:15,040 BLOOD OR OTHER TISSUE, 3939 02:25:15,040 --> 02:25:16,040 CONSEQUENT TO STRESS SOMETIMES 3940 02:25:16,040 --> 02:25:17,680 AS PARTS OF DEVELOPMENTAL 3941 02:25:17,680 --> 02:25:21,160 COHORT. AND TRYING TO UNDERSTAND 3942 02:25:21,160 --> 02:25:22,320 REPRODUCIBILITY OF THE FINDINGS 3943 02:25:22,320 --> 02:25:24,760 FROM THOSE STUDIES IS ONE OF THE 3944 02:25:24,760 --> 02:25:27,640 MAIN DRIVERS FOR THIS WORK. SO I 3945 02:25:27,640 --> 02:25:31,880 WOULD SAY ABSOLUTELY DOES IMPACT 3946 02:25:31,880 --> 02:25:34,040 ON IN BOTH CLINICAL REALM AND 3947 02:25:34,040 --> 02:25:36,120 MECHANISTIC REALM AND ALMOST ALL 3948 02:25:36,120 --> 02:25:38,440 WORK DONE IN HUMANS. THEN TO 3949 02:25:38,440 --> 02:25:40,520 ANSWER YOUR FINAL QUESTION, I 3950 02:25:40,520 --> 02:25:42,240 THINK WHAT WE ARE NOT TALKING 3951 02:25:42,240 --> 02:25:43,360 ABOUT HERE SPECIALIZED 3952 02:25:43,360 --> 02:25:45,120 COLLECTIONS OF INDIVIDUALS WITH 3953 02:25:45,120 --> 02:25:47,640 PARTICULAR DISORDER THOUGH YES 3954 02:25:47,640 --> 02:25:48,960 SOMETIMES THOSE MIGHT BE 3955 02:25:48,960 --> 02:25:51,160 IMPACTED HERE. INSTEAD WE ARE 3956 02:25:51,160 --> 02:25:52,680 TALKING MORE ABOUT TEND TO BE 3957 02:25:52,680 --> 02:25:54,280 TALKING MORE ABOUT COHORT 3958 02:25:54,280 --> 02:25:55,920 STUDIES OR LARGE COLLECTIONS OF 3959 02:25:55,920 --> 02:25:57,360 PATIENTS, TYPICALLY FROM 3960 02:25:57,360 --> 02:25:59,120 MULTIPLE SITES, THAT ARE 3961 02:25:59,120 --> 02:26:01,320 HETEROGENOUS IN NATURE. THOUGH 3962 02:26:01,320 --> 02:26:03,800 SOME PRINCIPLES OF EXPERIMENTAL 3963 02:26:03,800 --> 02:26:04,720 DESIGN OUT-GROUP APPLY TO LARGE 3964 02:26:04,720 --> 02:26:06,840 COLLECTIONS OF INDIVIDUALS FROM 3965 02:26:06,840 --> 02:26:08,160 SPECIFIC -- SPECIFIED 3966 02:26:08,160 --> 02:26:11,120 POPULATIONS AS WELL. JOEL, I SEE 3967 02:26:11,120 --> 02:26:13,000 YOUR HANDS UP NEXT ANYONE LAURA. 3968 02:26:13,000 --> 02:26:14,240 ANYONE ELSE FEEL FREE TO GET IN 3969 02:26:14,240 --> 02:26:17,000 LINE. 3970 02:26:17,000 --> 02:26:20,560 >> JOSH I WANT TO PLOD THIS, 3971 02:26:20,560 --> 02:26:23,760 THIS IS THE RIGHT -- TO PLAID 3972 02:26:23,760 --> 02:26:25,880 THIS, RIGHT TRACK. WANT TO 3973 02:26:25,880 --> 02:26:27,280 HIGHLIGHT THE RELATIVE STUDIES 3974 02:26:27,280 --> 02:26:29,320 IN THESE FIELDS, I THINK YOU ARE 3975 02:26:29,320 --> 02:26:31,200 RIGHT TO REAWAKEN THAT 3976 02:26:31,200 --> 02:26:32,920 DISCUSSION A LITTLE MORE FOCUS 3977 02:26:32,920 --> 02:26:36,120 AS WELL AS REVISITING A 3978 02:26:36,120 --> 02:26:38,440 PERIPHERAL DIMERS THINGS LIKE 3979 02:26:38,440 --> 02:26:41,880 CYTOKINES WHICH WE STUDIED AND 3980 02:26:41,880 --> 02:26:43,640 OTHER THINGS OTHERS HAVE STUDIED 3981 02:26:43,640 --> 02:26:45,800 WHAT CAN IMAGINE POTENTIAL YOU 3982 02:26:45,800 --> 02:26:48,200 UNTILTY OF BIOMARKERS AS A 3983 02:26:48,200 --> 02:26:50,600 POTENTIAL PROBLEM SO IF YOU DO 3984 02:26:50,600 --> 02:26:51,760 IT THOROUGHLY SO, I THINK THOSE 3985 02:26:51,760 --> 02:26:54,200 ARE THE RIGHT QUESTIONS TO A 3986 02:26:54,200 --> 02:26:55,800 LARGE EXTENT. A LOT OF THE 3987 02:26:55,800 --> 02:26:57,920 PROBLEM HERE I SEE IS DIFFICULTY 3988 02:26:57,920 --> 02:27:00,160 OF SOLVING THE MULTIPLE TESTING 3989 02:27:00,160 --> 02:27:01,480 PROBLEM WITH SMALL SAMPLES. 3990 02:27:01,480 --> 02:27:03,640 THAT IS IMPLIED IN WHAT YOU SAID 3991 02:27:03,640 --> 02:27:04,560 BUT MIGHT BE WORTH CALLING OUT 3992 02:27:04,560 --> 02:27:06,720 BECAUSE IT IS ONE OF THE 3993 02:27:06,720 --> 02:27:09,120 PRINCIPLE CHALLENGES DON'T THINK 3994 02:27:09,120 --> 02:27:10,640 I HAVE SEEN THAT LACKS 3995 02:27:10,640 --> 02:27:11,960 IMAGINATION TO SOLVE, JUST 3996 02:27:11,960 --> 02:27:15,200 REMAIN AS BRUTE FORCE. SO THAT'S 3997 02:27:15,200 --> 02:27:16,200 SOMETHING THAT -- OVERALL THIS 3998 02:27:16,200 --> 02:27:17,840 IS REALLY GOOD SO I WANT TO JUST 3999 02:27:17,840 --> 02:27:18,200 SUPPORT IT. 4000 02:27:18,200 --> 02:27:20,600 >> THANK YOU, JOEL. LET ME 4001 02:27:20,600 --> 02:27:22,200 RESPOND TO THAT LAST COMMENT YOU 4002 02:27:22,200 --> 02:27:24,160 MADE YOU ARE RIGHT THE MULTIPLE 4003 02:27:24,160 --> 02:27:25,160 TESTING PROBLEM, DOES DRIVE A 4004 02:27:25,160 --> 02:27:27,640 LOT OF THE ISSUES IN THIS AREA. 4005 02:27:27,640 --> 02:27:30,000 I WOULD SAY THERE IS A LOT OF 4006 02:27:30,000 --> 02:27:31,240 CREATIVITY IN TRYING TO SOLVE IT 4007 02:27:31,240 --> 02:27:33,480 BUT NOT A LOT OF THE RIGOR IN 4008 02:27:33,480 --> 02:27:36,280 THAT CREATIVITY. SO TONS OF 4009 02:27:36,280 --> 02:27:38,920 DIFFERENT APPROACHES, AND THAT 4010 02:27:38,920 --> 02:27:42,000 ARE BEING USED IN PAPERS. AND 4011 02:27:42,000 --> 02:27:47,320 YET I DON'T SEE THE CANONICAL 4012 02:27:47,320 --> 02:27:48,200 AGREEMENT CONSENSUS IN THE FIELD 4013 02:27:48,200 --> 02:27:49,200 THAT ANY ONE OF THIS IS 4014 02:27:49,200 --> 02:27:51,360 APPROACHES IS AT ALL VALID. AND 4015 02:27:51,360 --> 02:27:53,000 IN FACT WHAT YOU GET, I HAVE 4016 02:27:53,000 --> 02:27:54,400 SEEN THIS AS REVIEWER ON THE 4017 02:27:54,400 --> 02:27:55,880 HANDFUL OF LARGE DATA STUFF THAT 4018 02:27:55,880 --> 02:27:59,560 I REVIEW IN ANIMAL WORK, WHERE 4019 02:27:59,560 --> 02:28:02,200 IT IS A NOVEL METHOD THAT THE 4020 02:28:02,200 --> 02:28:03,760 AUTHORS IN OUR CONDENSED WORK, 4021 02:28:03,760 --> 02:28:05,560 THEY HAVE HAD LOTS OF 4022 02:28:05,560 --> 02:28:07,880 COLLABORATORS ON THE PAPER WHO 4023 02:28:07,880 --> 02:28:09,080 DEVELOP THE METHOD THEY THINK 4024 02:28:09,080 --> 02:28:10,840 WORK, I HAVE NO EXPERTISE TO 4025 02:28:10,840 --> 02:28:13,360 REVIEW IT. SO THERE ARE LOT OF 4026 02:28:13,360 --> 02:28:16,000 THESE ONE OFFS AND NOT A GOOD 4027 02:28:16,000 --> 02:28:17,440 CONSENSUS IN THE FIELD IN TERMS 4028 02:28:17,440 --> 02:28:19,920 OF WHICH METHODS THAT ACTUALLY 4029 02:28:19,920 --> 02:28:23,000 RIGOROUS AND WHICH ARE PROVEN TO 4030 02:28:23,000 --> 02:28:23,920 BE REPRODUCIBLE OVER TIME. 4031 02:28:23,920 --> 02:28:24,720 APPRECIATE THE COMMENT. 4032 02:28:24,720 --> 02:28:26,600 >> AGREE WITH THAT LAST POINT AS 4033 02:28:26,600 --> 02:28:29,080 WELL. SOMETIMES THEY FORGET THE 4034 02:28:29,080 --> 02:28:30,640 -- THEY ARE FORGETS FUNDAMENTALS 4035 02:28:30,640 --> 02:28:31,760 HOW TO REDUCE NUMBER OF TESTS 4036 02:28:31,760 --> 02:28:33,840 GETTING TOO FANCY INSTEAD OF 4037 02:28:33,840 --> 02:28:35,080 SIMPLIFYING BUT NOT TO GET INTO 4038 02:28:35,080 --> 02:28:35,600 THE WEEDS. 4039 02:28:35,600 --> 02:28:37,240 >> THEN AS YOU POINT OUT THE 4040 02:28:37,240 --> 02:28:38,280 OTHER METHODS REDUCE THE 4041 02:28:38,280 --> 02:28:39,280 COMPLEXITY OF THE NUMBER OF 4042 02:28:39,280 --> 02:28:41,800 TESTS IS TO HAVE A SPECIFIC 4043 02:28:41,800 --> 02:28:42,880 HYPOTHESIS, THE IMAGING WORLD 4044 02:28:42,880 --> 02:28:44,400 HAS LEFT THAT BEHIND BECAUSE 4045 02:28:44,400 --> 02:28:45,880 FAILURE THE REPRODUCE AS WELL, 4046 02:28:45,880 --> 02:28:47,880 AS THAT HAS GENETIC WORLD. SO 4047 02:28:47,880 --> 02:28:48,920 UNDER WHAT CONSIDERATION WOULD 4048 02:28:48,920 --> 02:28:51,040 WE ALLOW THAT IN THIS REALM, IN 4049 02:28:51,040 --> 02:28:53,080 THE REALM OF OTHER HIGH 4050 02:28:53,080 --> 02:28:54,880 DIMENSIONAL DATA SETS. LAURA, 4051 02:28:54,880 --> 02:28:55,440 YOU ARE NEXT. 4052 02:28:55,440 --> 02:28:57,560 >> SO I WANT TO ECHO WHAT JOEL 4053 02:28:57,560 --> 02:29:00,520 SAID, I THINK YOU HAVE ASKED A 4054 02:29:00,520 --> 02:29:02,000 LOT OF GREAT QUESTIONS HERE AND 4055 02:29:02,000 --> 02:29:04,200 THAT COMING UP WITH STRATEGIES 4056 02:29:04,200 --> 02:29:06,680 TO ADDRESS THESE COMPLEX ISSUES 4057 02:29:06,680 --> 02:29:09,040 CAN REALLY HELP TO MOVE THE 4058 02:29:09,040 --> 02:29:10,800 FIELD FORWARD. I WILL SAY THAT I 4059 02:29:10,800 --> 02:29:14,120 WOULD BE HAPPY TO BE PART OF 4060 02:29:14,120 --> 02:29:15,280 THIS CONVERSATION SO YOU CAN PUT 4061 02:29:15,280 --> 02:29:17,200 ME DOWN ON THE LIST OF POTENTIAL 4062 02:29:17,200 --> 02:29:18,480 VOLUNTEERS. THAT IS REGARDLESS 4063 02:29:18,480 --> 02:29:19,720 OF YOUR ANSWER TO MY NEXT 4064 02:29:19,720 --> 02:29:22,920 QUESTION. WHICH IS YOU FRAMED 4065 02:29:22,920 --> 02:29:26,320 THIS STARTING FROM THE GUIDANCE 4066 02:29:26,320 --> 02:29:28,000 ON THE GENE LOCALIZATION AND 4067 02:29:28,000 --> 02:29:30,480 GENOMIC STUDIES. SO I'M 4068 02:29:30,480 --> 02:29:34,040 WONDERING WHETHER YOU SEE THE 4069 02:29:34,040 --> 02:29:36,400 WORK OF THIS COMMITTEE AS BEING 4070 02:29:36,400 --> 02:29:37,880 COMPLETELY SEPARATE FROM THAT OR 4071 02:29:37,880 --> 02:29:41,400 IN DIALOGUE WITH IT OR DO THE 4072 02:29:41,400 --> 02:29:43,440 GENE LOCALIZATIONS GET THROWN 4073 02:29:43,440 --> 02:29:47,040 BACK INTO THE MIX AS WELL NOW? 4074 02:29:47,040 --> 02:29:50,280 >> IT IS MY OPINION, AND -- 4075 02:29:50,280 --> 02:29:52,480 Y'ALL MAY DISAGREE, BUT THAT THE 4076 02:29:52,480 --> 02:29:53,640 RECOMMENDATIONS OF THAT WORK 4077 02:29:53,640 --> 02:29:55,040 GROUP SORT OF HAVE STOOD THE 4078 02:29:55,040 --> 02:30:00,080 TEST OF TIME. THAT WE WILL 4079 02:30:00,080 --> 02:30:01,840 INSIST UPON GENOME WIDE LEVELS 4080 02:30:01,840 --> 02:30:03,960 OF SIGNIFICANCE IF WE ARE TO 4081 02:30:03,960 --> 02:30:06,240 DECLARE A GENE LINK FOR 4082 02:30:06,240 --> 02:30:07,960 SCHIZOPHRENIA, DOESN'T MEAN GWAS 4083 02:30:07,960 --> 02:30:10,600 BUT WE NEED TO SURVIVE THAT 4084 02:30:10,600 --> 02:30:14,120 MULTIPLE TESTING PROBLEM,S THE 4085 02:30:14,120 --> 02:30:16,360 REASON WHY PERHAPS IF IT HAS 4086 02:30:16,360 --> 02:30:17,760 STOOD THE TEST OF TIME, THE 4087 02:30:17,760 --> 02:30:19,600 REASON WHY IT HAS IS BECAUSE I 4088 02:30:19,600 --> 02:30:22,240 THINK THERE WAS A CONSENSUS IN 4089 02:30:22,240 --> 02:30:24,200 THE FIELD THAT THE MULTIPLE -- 4090 02:30:24,200 --> 02:30:27,120 THE ONLY WAY TO SOLVE MULTIPLE 4091 02:30:27,120 --> 02:30:29,080 TESTING PROBLEM IS INCREASE 4092 02:30:29,080 --> 02:30:31,480 DRAMATICALLY SIZE OF SAMPLES. 4093 02:30:31,480 --> 02:30:32,840 THAT IS I THINK WORKING SO I 4094 02:30:32,840 --> 02:30:35,600 DON'T THINK THERE IS A NEED TO 4095 02:30:35,600 --> 02:30:36,720 REVISIT RECOMMENDATIONS IN SPACE 4096 02:30:36,720 --> 02:30:40,800 OF GENOMICS. BUT THOSE SAME 4097 02:30:40,800 --> 02:30:43,200 LEVEL OF RIGOR DOESN'T SEEM TO 4098 02:30:43,200 --> 02:30:44,840 BE BEING APPLIED TO THESE OTHER 4099 02:30:44,840 --> 02:30:47,040 FORMS OF HIGH DIMENSIONAL DATA 4100 02:30:47,040 --> 02:30:50,480 OR IS APPLIED PERHAPS LESS 4101 02:30:50,480 --> 02:30:53,360 UNIFORMLY. AND I DON'T SEE A 4102 02:30:53,360 --> 02:30:55,480 CONSENSUS IN THE FIELD, IF WE 4103 02:30:55,480 --> 02:30:59,680 WERE TO INSIST ON THE ABSOLUTE 4104 02:30:59,680 --> 02:31:02,120 SAME LEVEL OF STATISTICAL 4105 02:31:02,120 --> 02:31:03,920 CONFIDENCE, THE MULTIPLE TESTING 4106 02:31:03,920 --> 02:31:05,560 PROBLEM BEING SOLVED BY IMMENSE 4107 02:31:05,560 --> 02:31:07,640 DATA SETS WE ARE STUCK WITH THE 4108 02:31:07,640 --> 02:31:11,560 RECOMMENDATION THAT CAME OUT OF 4109 02:31:11,560 --> 02:31:13,160 THE (INDISCERNIBLE) WORK YOU 4110 02:31:13,160 --> 02:31:14,440 NEED THOUSANDS OF INDIVIDUALS 4111 02:31:14,440 --> 02:31:15,960 FOR NEURAL IMAGING AND PROBABLY 4112 02:31:15,960 --> 02:31:17,800 NEED TENS OR HUNDREDS OF 4113 02:31:17,800 --> 02:31:19,440 THOUSANDS IF YOU WANT TO LINK 4114 02:31:19,440 --> 02:31:20,600 MULTIPLE HIGH DIMENSIONAL DATA 4115 02:31:20,600 --> 02:31:23,400 SETS TOGETHER. SO THAT MAY BE 4116 02:31:23,400 --> 02:31:24,960 WHAT WE SAY IN WHICH CASE THE 4117 02:31:24,960 --> 02:31:26,760 VAST MAJORITY OF FUNDING ARE NO 4118 02:31:26,760 --> 02:31:28,600 LONGER GOING TO BE FUNDABLE IN 4119 02:31:28,600 --> 02:31:31,080 THE THIS BASIS. BUT IT MAY BE 4120 02:31:31,080 --> 02:31:32,760 THERE ARE METHODS FOR 4121 02:31:32,760 --> 02:31:33,760 DIMENSIONALITY REDUCTION THAT 4122 02:31:33,760 --> 02:31:35,400 ARE MORE ACCEPTABLE IN THESE 4123 02:31:35,400 --> 02:31:37,320 OTHER AREAS BECAUSE WE ARE 4124 02:31:37,320 --> 02:31:38,520 TALKING ABOUT BIOLOGICAL 4125 02:31:38,520 --> 02:31:39,760 MECHANISMS OR BECAUSE WE HAVE 4126 02:31:39,760 --> 02:31:42,200 CONFIDENCE IN THEIR 4127 02:31:42,200 --> 02:31:43,360 REPRODUCIBILITY OR MAYBE THE 4128 02:31:43,360 --> 02:31:44,160 GROUP SAYS YOU KNOW WHAT, WE 4129 02:31:44,160 --> 02:31:47,800 DON'T KNOW BUT WE URGE NIMH TO 4130 02:31:47,800 --> 02:31:49,800 SUPPORT THE KINDS OF STUDIES 4131 02:31:49,800 --> 02:31:51,440 THAT COMPARE DIFFERENT METHODS 4132 02:31:51,440 --> 02:31:52,440 FOR DIMENSIONALITY REDUCTION. SO 4133 02:31:52,440 --> 02:31:53,720 THOSE WILL THE KINDS OF THINGS I 4134 02:31:53,720 --> 02:31:54,880 CAN IMAGINE COMING OUT OF THIS 4135 02:31:54,880 --> 02:31:58,240 GROUP. ANSWER SPECIFIC QUESTION, 4136 02:31:58,240 --> 02:32:00,280 NO I DON'T THINK WE NEED TO 4137 02:32:00,280 --> 02:32:02,520 REVISIT GENE FINDING PER SE, 4138 02:32:02,520 --> 02:32:04,120 THOUGH OF COURSE IF THE GROUP 4139 02:32:04,120 --> 02:32:05,880 FELT SO, I WOULD BE OPEN TO 4140 02:32:05,880 --> 02:32:11,760 LISTEN TO THAT. TED. 4141 02:32:11,760 --> 02:32:13,760 >> THANKS, JOSH. I ECHO THE 4142 02:32:13,760 --> 02:32:15,280 COMMENTS. ONE COMMENT ABOUT 4143 02:32:15,280 --> 02:32:17,480 GENE FINDING IS TO REALIZE THAT 4144 02:32:17,480 --> 02:32:18,920 MOST OF THE GENOME IS ACTUALLY 4145 02:32:18,920 --> 02:32:21,840 COVERED BY WHAT YOU JUST 4146 02:32:21,840 --> 02:32:24,200 DISCUSSED WHICH IS EPIGENETICS 4147 02:32:24,200 --> 02:32:27,640 SO WE WILL WINDS UPCOMING IN TO 4148 02:32:27,640 --> 02:32:29,440 THAT. CONVERSATION BUT THAT 4149 02:32:29,440 --> 02:32:32,360 DOESN'T MEAN WE HAVE TO REWRITE 4150 02:32:32,360 --> 02:32:32,880 THOSE RECOMMENDATIONS. THE 4151 02:32:32,880 --> 02:32:36,200 COUPLE OF THINGS THAT COME TO 4152 02:32:36,200 --> 02:32:39,240 MIND, ONE IS STUPID LITTLE THING 4153 02:32:39,240 --> 02:32:41,120 THAT HAPPENED LESS THAN 15 YEARS 4154 02:32:41,120 --> 02:32:43,120 AGO OR LONGER WHEN WE LOOK BACK 4155 02:32:43,120 --> 02:32:44,800 ON OUR MICROARRAY STUDIES AND 4156 02:32:44,800 --> 02:32:47,840 REALIZE THE MOST SIGNIFICANT 4157 02:32:47,840 --> 02:32:49,560 COMPONENT OF VARIATION WAS THE 4158 02:32:49,560 --> 02:32:51,240 NAME OF THE TECHNICIAN WHO RAN 4159 02:32:51,240 --> 02:32:53,400 IT. IN FACT. SO THERE ARE SOME 4160 02:32:53,400 --> 02:32:55,720 ISSUES HERE WHERE WE DON'T HAVE 4161 02:32:55,720 --> 02:32:58,640 THE TECHNOLOGIES SORTED OUT AND 4162 02:32:58,640 --> 02:33:00,600 THAT IS A CHALLENGE. THERE ARE 4163 02:33:00,600 --> 02:33:01,960 ALSO BIOLOGICAL CHALLENGES. IT 4164 02:33:01,960 --> 02:33:06,520 IS WORTH NOTING IN THE BROADEN 4165 02:33:06,520 --> 02:33:07,520 BIOLOGY WE HAVE COMPLETE 4166 02:33:07,520 --> 02:33:08,680 SUPPOSEDLY COMPLETE CONTROL OF 4167 02:33:08,680 --> 02:33:09,800 OUR SUBJECTS, IF WE WERE TO TRY 4168 02:33:09,800 --> 02:33:11,160 TO LOOK GENOME WIDE FOR 4169 02:33:11,160 --> 02:33:13,440 EPIGENETIC CHANGES WITH BEHAVIOR 4170 02:33:13,440 --> 02:33:16,200 THEY ARE HARD TO FIND. YOU CAN 4171 02:33:16,200 --> 02:33:18,400 FIND WITH LOOKING AT SPECIFIC 4172 02:33:18,400 --> 02:33:20,240 GENES OR DOING SPECIFIC THINGS 4173 02:33:20,240 --> 02:33:21,040 BUT IT IS A DIFFICULT PROBLEM. 4174 02:33:21,040 --> 02:33:22,400 COUPLE OF THINGS YOU DIDN'T 4175 02:33:22,400 --> 02:33:25,160 MENTION THAT COME TO MIND, ONE 4176 02:33:25,160 --> 02:33:26,440 IS THIS DIFFERENCE BETWEEN 4177 02:33:26,440 --> 02:33:27,880 STATES AND TRAIT TRAITS. WE GET 4178 02:33:27,880 --> 02:33:29,800 CONFUSED IN THIS, WHERE WE THINK 4179 02:33:29,800 --> 02:33:31,480 OF WHAT WE HAVE IS LOOKING FOR 4180 02:33:31,480 --> 02:33:33,760 SOMETHING STABLE BUT SOMETHING 4181 02:33:33,760 --> 02:33:35,320 CHANGING AND YOU NOT TALKED 4182 02:33:35,320 --> 02:33:36,840 ABOUT OPPORTUNITIES ASSOCIATED 4183 02:33:36,840 --> 02:33:38,240 WITH DISEASE, YOU CAN IMAGINE 4184 02:33:38,240 --> 02:33:39,600 STABLE VERSUS THOSE ASSOCIATED 4185 02:33:39,600 --> 02:33:43,720 WITH STRESS WHICH MIGHT BE -- 4186 02:33:43,720 --> 02:33:46,080 MORE CHANGE. THE OTHER ISSUE IS 4187 02:33:46,080 --> 02:33:47,160 OBVIOUSLY VARIABILITY. 4188 02:33:47,160 --> 02:33:49,320 >> TED, CAN I INTERRUPT THAT TO 4189 02:33:49,320 --> 02:33:51,560 FOCUS ON THAT. I THINK KATIE'S 4190 02:33:51,560 --> 02:33:54,080 TALK INTERESTINGLY ENOUGH 4191 02:33:54,080 --> 02:33:56,560 ADDRESSED THAT ISSUE. SHE'S 4192 02:33:56,560 --> 02:33:58,280 CHOSEN TO WORK WITH INDIVIDUALS 4193 02:33:58,280 --> 02:33:59,560 OVER TIME MULTIPLE REPEATED 4194 02:33:59,560 --> 02:34:01,800 THING. THAT MIGHT BE ONE 4195 02:34:01,800 --> 02:34:02,440 RECOMMENDATION THE GROUP TO COME 4196 02:34:02,440 --> 02:34:05,720 UP WITH TO EMPHASIZE, THAT WAS 4197 02:34:05,720 --> 02:34:08,240 ALSO RECOMMENDATION THE 4198 02:34:08,240 --> 02:34:09,840 DIZZENBACH PAPER. WE FOCUS ON 4199 02:34:09,840 --> 02:34:11,240 ONE EXPERIMENTAL DESIGN LESS 4200 02:34:11,240 --> 02:34:13,440 PRONE TO ISSUES OF MULTIPLE 4201 02:34:13,440 --> 02:34:14,840 COMPARISONS. KEEP GOING. 4202 02:34:14,840 --> 02:34:18,000 >> SO THE OTHER CHALLENGE IS 4203 02:34:18,000 --> 02:34:19,520 CONNECTING -- TALKING ABOUT BIG 4204 02:34:19,520 --> 02:34:22,360 DATA SETS AND YOU TALKED ABOUT 4205 02:34:22,360 --> 02:34:24,320 THE DATA, EPIGENETIC DATA. BUT 4206 02:34:24,320 --> 02:34:26,280 YOU DIDN'T TALK A LOT ABOUT 4207 02:34:26,280 --> 02:34:27,520 CLINICAL DATA FOR WHICH I HAVE 4208 02:34:27,520 --> 02:34:30,200 NO EXPERIENCE WITH. BUT THERE WE 4209 02:34:30,200 --> 02:34:33,040 HAVE SIGNIFICANT VARIATION TOO 4210 02:34:33,040 --> 02:34:36,200 IN THAT MAYBE WE HAVE A 4211 02:34:36,200 --> 02:34:39,000 DIAGNOSIS THAT ONE DOCTOR GIVE 4212 02:34:39,000 --> 02:34:41,640 AND NEXT DOCTOR GIVE SMIDDYING 4213 02:34:41,640 --> 02:34:43,040 SUPPOSE BUT IT DOESN'T REFLECT 4214 02:34:43,040 --> 02:34:44,800 THE SAME UNDERLYING BIOLOGY SO 4215 02:34:44,800 --> 02:34:47,960 THE OTHER CHALLENGE IS WE TRYING 4216 02:34:47,960 --> 02:34:49,120 TO CONNECT ALL THIS SEQUENCING 4217 02:34:49,120 --> 02:34:50,880 TO AND IT ALSO HAS COMPLEXITY. 4218 02:34:50,880 --> 02:34:52,800 >> THAT'S RIGHT. SO ONE COULD 4219 02:34:52,800 --> 02:34:55,640 ALSO IN THAT SAME VEIN ONE 4220 02:34:55,640 --> 02:34:57,320 RECOMMENDATION MIGHT BE DON'T DO 4221 02:34:57,320 --> 02:34:59,560 EPIGENETICS AND DIAGNOSES, DO 4222 02:34:59,560 --> 02:35:02,680 THEM MORE CAREFULLY DEFINED M. 4223 02:35:02,680 --> 02:35:05,600 OR WHAT ARE CHARACTERISTICS BY 4224 02:35:05,600 --> 02:35:06,960 WHICH YOU COULD IMAGINE DOING 4225 02:35:06,960 --> 02:35:09,480 THAT. APPRECIATE THAT 4226 02:35:09,480 --> 02:35:21,200 PERSPECTIVE. BRINE THEPER SPEC . 4227 02:35:23,600 --> 02:35:26,800 >> THIS IS A IDEA LONG OVERDUE. 4228 02:35:26,800 --> 02:35:28,520 WE WORK WITH BIG DATA OVER TIME. 4229 02:35:28,520 --> 02:35:33,120 COUPLE OF PERSPECTIVES, SO I WAS 4230 02:35:33,120 --> 02:35:36,480 RECENTLY AT THIS CELL SYMPOSIUM 4231 02:35:36,480 --> 02:35:37,360 AND DAMIAN FAIR PRESENT THIRD 4232 02:35:37,360 --> 02:35:37,960 DEGREE STUDY. THAT YOU JUST 4233 02:35:37,960 --> 02:35:41,920 SUMMARIZED. THERE WERE TWO 4234 02:35:41,920 --> 02:35:45,000 THINGS REMARKABLE TO ME. FIRST, 4235 02:35:45,000 --> 02:35:47,000 I THINK EVERYBODY AGREED IT WAS 4236 02:35:47,000 --> 02:35:49,320 AN ASTOUNDING SET OF FINDINGS 4237 02:35:49,320 --> 02:35:52,200 AND THE SECOND WAS AFTER HIS 4238 02:35:52,200 --> 02:35:54,680 TALK, HE WAS ABSOLUTELY MOBBED 4239 02:35:54,680 --> 02:35:57,320 BY STUDENTS AND POST-DOCS WHO 4240 02:35:57,320 --> 02:35:59,000 WANTED TO WORK WITH HIM ON THESE 4241 02:35:59,000 --> 02:36:03,160 PROBLEMS. SO IT CAPTURED THE 4242 02:36:03,160 --> 02:36:04,840 IMAGINATION OF THE NEXT COHORT 4243 02:36:04,840 --> 02:36:09,080 OF NEUROSCIENTISTS. AND I KNOW 4244 02:36:09,080 --> 02:36:12,400 YOU ARE AWARE BUT YOU PROBABLY 4245 02:36:12,400 --> 02:36:15,160 WANT TO PUT ON YOUR DEFLECTOR 4246 02:36:15,160 --> 02:36:16,840 SCREENS BECAUSE THERE WILL BE 4247 02:36:16,840 --> 02:36:19,760 JUST I REMEMBER THE SAME 4248 02:36:19,760 --> 02:36:22,000 CONVERSATION THAT WE HAD WHEN 4249 02:36:22,000 --> 02:36:23,080 THE INITIAL RECOMMENDATIONS FROM 4250 02:36:23,080 --> 02:36:25,720 THE GENETICIST CAME OUT, TO NO 4251 02:36:25,720 --> 02:36:29,000 LONGER DO TARGETED STUDY BUS TO 4252 02:36:29,000 --> 02:36:31,240 DO UNBIASED GENOME WIDE 4253 02:36:31,240 --> 02:36:32,920 ASSOCIATION STUDIES. THERE WAS 4254 02:36:32,920 --> 02:36:34,120 TREMENDOUS PUSH BACK, THERE 4255 02:36:34,120 --> 02:36:36,320 STILL IS PUSH BACK FROM SOME 4256 02:36:36,320 --> 02:36:37,720 QUARTERS BUT I THINK THE VAST 4257 02:36:37,720 --> 02:36:38,960 MAJORITY OF PEOPLE AGREE THAT 4258 02:36:38,960 --> 02:36:42,320 THAT WAS REALLY A BIG STEP IN 4259 02:36:42,320 --> 02:36:43,240 THE RIGHT DIRECTION. I THINK IT 4260 02:36:43,240 --> 02:36:46,360 WAS THE SAME FOR THIS. BUT THERE 4261 02:36:46,360 --> 02:36:47,960 WILL BE I MEAN YOU ARE AWARE 4262 02:36:47,960 --> 02:36:51,800 THERE WILL BE SOME PUSH BACK. 4263 02:36:51,800 --> 02:36:55,120 BUT I'M 100 -- 110% BEHIND IT. 4264 02:36:55,120 --> 02:36:59,040 >> THANKS, BRIAN. SOFIA, YOU GET 4265 02:36:59,040 --> 02:37:00,240 THE LUXURY OF THE PRIVILEGE OF 4266 02:37:00,240 --> 02:37:01,360 THE LAST QUESTION OR COMMENT IT 4267 02:37:01,360 --> 02:37:05,360 IS TIME TO MOVE ON. WE CAN'T 4268 02:37:05,360 --> 02:37:11,720 HEAR YOU. YOU HAVE TO UNMUTE. 4269 02:37:11,720 --> 02:37:13,480 >> BRIAN STOLE SOME OF MY 4270 02:37:13,480 --> 02:37:16,000 THUNDER BUT HAVING SEEN AN 4271 02:37:16,000 --> 02:37:19,360 WORKING NOW CAN DAMIAN FAIR, ONE 4272 02:37:19,360 --> 02:37:21,240 OF THE HIGHLIGHTS TO EMPHASIZE 4273 02:37:21,240 --> 02:37:22,840 IS THAT SOME OF THESE TECHNIQUES 4274 02:37:22,840 --> 02:37:25,520 ARE CHANGING RAPIDLY. SO NOW 4275 02:37:25,520 --> 02:37:26,760 THERE'S PRECISION BRAIN MAPPING 4276 02:37:26,760 --> 02:37:29,440 WHICH INTERESTINGLY REQUIRES A 4277 02:37:29,440 --> 02:37:31,560 LONG PERIOD OF SCAN TIME AND 4278 02:37:31,560 --> 02:37:33,760 IDEALLY REPEATED SCANS ACROSS 4279 02:37:33,760 --> 02:37:35,160 SESSIONS WITH INDIVIDUALS, SO WE 4280 02:37:35,160 --> 02:37:37,320 REALLY ARE TALKING ABOUT 4281 02:37:37,320 --> 02:37:38,640 SHIFTING PARADIGMS ON THEIR HEAD 4282 02:37:38,640 --> 02:37:40,360 SO THAT AGAIN IS SORT OF SUPPORT 4283 02:37:40,360 --> 02:37:42,640 OF WHAT BRIAN SAID. I WANT -- IN 4284 02:37:42,640 --> 02:37:44,000 THIS VEIN TO HIGHLIGHT A COMMENT 4285 02:37:44,000 --> 02:37:45,360 YOU JUST MADE, JOSH. WHICH IS 4286 02:37:45,360 --> 02:37:47,320 THAT PERHAPS THE DESIGNS WE NEED 4287 02:37:47,320 --> 02:37:49,920 TO START CONSIDERING ARE THESE 4288 02:37:49,920 --> 02:37:51,520 WITHIN SUBJECT LONGITUDINAL 4289 02:37:51,520 --> 02:37:54,360 DESIGNS. THE REASON I THINK THAT 4290 02:37:54,360 --> 02:37:54,880 WORTH HIGHLIGHTING IS WE 4291 02:37:54,880 --> 02:37:55,760 CONTINUE TO STRUGGLE ABOUT HOW 4292 02:37:55,760 --> 02:37:58,040 DO WE BRING THE RICHNESS OF THE 4293 02:37:58,040 --> 02:38:00,680 SCIENCE WE DO INTO THE CLINIC. 4294 02:38:00,680 --> 02:38:01,880 WE HAVE TO START THINKING THE 4295 02:38:01,880 --> 02:38:04,240 WAY CLINICIANS DO. AT SOME LEVEL 4296 02:38:04,240 --> 02:38:06,800 WHICH IS LONGITUDINAL WITHIN 4297 02:38:06,800 --> 02:38:08,560 INDIVIDUAL CHANGE OVER TIME. SO 4298 02:38:08,560 --> 02:38:10,880 I ACTUALLY SEE THAT WHILE THIS 4299 02:38:10,880 --> 02:38:13,120 WILL PERHAPS CREATE SOME HAVOC 4300 02:38:13,120 --> 02:38:14,960 AND GENERATE SOME PUSH BACK IT 4301 02:38:14,960 --> 02:38:17,640 POTENTIALLY ALSO OPENS UP A VERY 4302 02:38:17,640 --> 02:38:19,160 EXCITING NEW AVENUES FOR THE 4303 02:38:19,160 --> 02:38:19,880 TRANSLATIONAL COMPONENT OF THE 4304 02:38:19,880 --> 02:38:21,960 WORK. 4305 02:38:21,960 --> 02:38:24,200 >> THANK YOU VERY THANK YOU VERK 4306 02:38:24,200 --> 02:38:25,520 YOU ALL, THOSE WHO COMMENTED AND 4307 02:38:25,520 --> 02:38:27,320 THE REST OF YOU WHO THOUGHT 4308 02:38:27,320 --> 02:38:28,200 ABOUT IT AND WHICH WILL BE 4309 02:38:28,200 --> 02:38:29,920 SENDING OUT A REQUEST FOR 4310 02:38:29,920 --> 02:38:32,360 VOLUNTEERS TO SERVE ON THE WORK 4311 02:38:32,360 --> 02:38:34,000 GROUP AND ENCOURAGE YOU TO BE 4312 02:38:34,000 --> 02:38:35,040 GENEROUS WITH YOUR TIME EVEN IF 4313 02:38:35,040 --> 02:38:37,920 YOU FEEL LIKE YOU DON'T HAVE THE 4314 02:38:37,920 --> 02:38:40,280 EXPERTISE. ALONG THAT WE WILL 4315 02:38:40,280 --> 02:38:41,120 ALSO BE ASKING FOR 4316 02:38:41,120 --> 02:38:41,880 RECOMMENDATIONS OF INDIVIDUAL 4317 02:38:41,880 --> 02:38:43,680 THE EXTRAMURAL WORLD. WE HAVE 4318 02:38:43,680 --> 02:38:46,520 OUR OWN LIST THAT WE COMPOSED 4319 02:38:46,520 --> 02:38:48,080 BUT Y'ALL KNOW HAVE A WIDER NET 4320 02:38:48,080 --> 02:38:51,720 THAN WE DO. T SO WE WILL BE 4321 02:38:51,720 --> 02:38:53,320 ASKING FOR RECOMMENDATIONS OF 4322 02:38:53,320 --> 02:38:56,360 EXTRAMURAL SCIENTISTS YOU THINK 4323 02:38:56,360 --> 02:38:59,480 WOULD BRING EXPERTISE TO THE 4324 02:38:59,480 --> 02:39:01,280 PROBLEM AS WELL AS AN OPEN MIND 4325 02:39:01,280 --> 02:39:02,920 TO THINKING ABOUT WAYS TO SOLVE 4326 02:39:02,920 --> 02:39:06,360 THE PROBLEM. 4327 02:39:06,360 --> 02:39:08,040 ALL RIGHT. THANK YOU, VERY MUCH. 4328 02:39:08,040 --> 02:39:10,160 WITH THAT WE WILL MOVE ON TO THE 4329 02:39:10,160 --> 02:39:12,240 NEXT PHASE OF THE PROGRAM WHICH 4330 02:39:12,240 --> 02:39:15,680 I BELIEVE IS COUNCIL CLEARANCES 4331 02:39:15,680 --> 02:39:17,920 LET ME NAVIGATE BACK TO MY 4332 02:39:17,920 --> 02:39:18,280 AGENDA. 4333 02:39:18,280 --> 02:39:20,040 >> WE ACTUALLY HAVE TIME FOR 4334 02:39:20,040 --> 02:39:21,040 JUST A SHORT BREAK. 4335 02:39:21,040 --> 02:39:23,080 >> EXCELLENT. 4336 02:39:23,080 --> 02:39:25,320 >> TRYING TO MAKE SURE WE ALLOW 4337 02:39:25,320 --> 02:39:27,080 BREAKS SINCE WE ARE DOING A ZOOM 4338 02:39:27,080 --> 02:39:27,640 MARATHON. 4339 02:39:27,640 --> 02:39:28,920 >> EXCELLENT. YOU ARE RIGHT. I 4340 02:39:28,920 --> 02:39:30,760 SEE THAT. WE ARE GOING TO TAKE A 4341 02:39:30,760 --> 02:39:33,800 BREAK UNTIL 3:45. WHICH GIVES US 4342 02:39:33,800 --> 02:39:36,040 TEN MINUTES FROM NOW. SO AGAIN 4343 02:39:36,040 --> 02:39:37,600 FEEL FREE TO TURN OFF YOUR 4344 02:39:37,600 --> 02:39:40,000 VIDEOS AND MUTE YOURSELVES, BE 4345 02:39:40,000 --> 02:39:43,840 BACK AT 3:45. 4346 02:39:43,840 --> 02:39:45,920 >>WE'RE GOING TO GET STARTED. 4347 02:39:45,920 --> 02:39:49,800 3:45. THANK YOU AGAIN FOR YOUR 4348 02:39:49,800 --> 02:39:51,400 INPUT ON THE POTENTIAL WORK 4349 02:39:51,400 --> 02:39:52,840 GROUP. NOW WE'LL SWITCH TO 4350 02:39:52,840 --> 02:39:54,640 CONCEPT CLEARANCES AS YOU ARE 4351 02:39:54,640 --> 02:39:57,640 AWARE, AT EACH COUNCIL MEETING 4352 02:39:57,640 --> 02:39:59,080 NIMH STAFF PRESENTS SEVERAL 4353 02:39:59,080 --> 02:40:00,040 SCIENTIFIC CONCEPTS FOR YOUR 4354 02:40:00,040 --> 02:40:03,560 INPUT. THE PURPOSE OF THESE 4355 02:40:03,560 --> 02:40:04,560 CONCEPT CLEARANCES IS FOR NIMH 4356 02:40:04,560 --> 02:40:05,960 STAFF AND LEADERSHIP TO HEAR 4357 02:40:05,960 --> 02:40:08,440 YOUR FEEDBACK ON THESE FUTURE 4358 02:40:08,440 --> 02:40:10,360 RESEARCH DIRECTIONS. INCLUDING 4359 02:40:10,360 --> 02:40:13,520 SUGGESTIONS THAT WILL HELP 4360 02:40:13,520 --> 02:40:15,320 FURTHER SHAPE INITIATIVES. A 4361 02:40:15,320 --> 02:40:16,240 BRIEF DESCRIPTION OF EACH 4362 02:40:16,240 --> 02:40:18,280 CONCEPT WAS MADE AVAILABLE TO 4363 02:40:18,280 --> 02:40:22,640 YOU VIA THE COUNCIL SOFTWARE 4364 02:40:22,640 --> 02:40:25,160 PACKAGE WITH YOUR FEEDBACK NIMH 4365 02:40:25,160 --> 02:40:26,480 AIMS TO PROCEED WITH THE 4366 02:40:26,480 --> 02:40:28,040 ACTIVITY. HOWEVER, THE 4367 02:40:28,040 --> 02:40:31,320 PUBLICATION AND TIMING IS NOT 4368 02:40:31,320 --> 02:40:33,280 CERTAIN AND DEPENDS ON 4369 02:40:33,280 --> 02:40:33,760 SUFFICIENT FUNDS BEING 4370 02:40:33,760 --> 02:40:37,000 AVAILABLE. ONCE PRESENTED 4371 02:40:37,000 --> 02:40:38,880 PUBLICLY AT COUNCIL CONCEPTS ARE 4372 02:40:38,880 --> 02:40:40,480 POSTED ON THE NIMH WEBSITE AND 4373 02:40:40,480 --> 02:40:42,920 ARE AVAILABLE FOR FURTHER 4374 02:40:42,920 --> 02:40:45,760 COMMENT. THE PURPOSE OF TODAY'S 4375 02:40:45,760 --> 02:40:47,600 DISCUSSION WE HAVE ASKED TWO 4376 02:40:47,600 --> 02:40:50,080 COUNCIL MEMBERS TO MAKE COMMENTS 4377 02:40:50,080 --> 02:40:51,760 ON EACH CONCEPT THOUGH WE 4378 02:40:51,760 --> 02:40:52,840 WELCOME FEEDBACK FROM ALL OF 4379 02:40:52,840 --> 02:40:56,120 YOU. THE FIRST CONCEPT WILL BE 4380 02:40:56,120 --> 02:40:58,640 PRESENTED BY JULIA ZEHR, 4381 02:40:58,640 --> 02:40:59,640 DIVISION OF TRANSLATIONAL 4382 02:40:59,640 --> 02:41:01,560 RESEARCH TITLED UNDERSTANDING 4383 02:41:01,560 --> 02:41:05,800 SOCIAL MEDIA AND YOUTH MENTAL 4384 02:41:05,800 --> 02:41:07,640 HEALTH. 4385 02:41:07,640 --> 02:41:15,960 >> YES, THANK YO THANK YOU. I'D 4386 02:41:15,960 --> 02:41:17,160 TO PRESENT THIS CONCEPT AND I 4387 02:41:17,160 --> 02:41:19,600 WOULD LIKE TO THANK DR. SMITH 4388 02:41:19,600 --> 02:41:21,200 AND (INAUDIBLE) FOR THEIR WORKED 4389 02:41:21,200 --> 02:41:22,960 WELL. THE GOAL OF THE CONCEPT 4390 02:41:22,960 --> 02:41:24,880 IS BETTER UNDERSTAND THE ROLE OF 4391 02:41:24,880 --> 02:41:27,640 SOCIAL MEDIA BEHAVIORS IN YOUTH 4392 02:41:27,640 --> 02:41:29,640 MENTAL HEALTH. IN SEPTEMBER THE 4393 02:41:29,640 --> 02:41:32,000 SURGEON GENERAL ADMINISTERED A 4394 02:41:32,000 --> 02:41:33,880 ADVISORY, HIGHLIGHTING THE NEED 4395 02:41:33,880 --> 02:41:35,640 FOR MORE SOCIAL MEDIA. RESEARCH 4396 02:41:35,640 --> 02:41:40,720 HAS BEEN CHALLENGING FOR MANY 4397 02:41:40,720 --> 02:41:43,480 REASONS ONE IS IT IS DIFFICULT 4398 02:41:43,480 --> 02:41:45,680 TO CAPTURE SOCIAL MEDIA 4399 02:41:45,680 --> 02:41:47,720 BEHAVIORS ENGAGEMENT AND CONTEXT 4400 02:41:47,720 --> 02:41:50,080 FROM DIGITAL ECOSYSTEM. A SECOND 4401 02:41:50,080 --> 02:41:53,280 REASON IS THAT THE WAYS IN WHICH 4402 02:41:53,280 --> 02:41:55,000 YOUTH ACT WITH SOCIAL MEDIA AS 4403 02:41:55,000 --> 02:41:57,040 WELL AS DIGITAL PLATFORMS AND 4404 02:41:57,040 --> 02:41:58,560 THE SYSTEMS THEMSELVES HAVE 4405 02:41:58,560 --> 02:41:59,800 CHANGE VERY RAPIDLY OVER THE 4406 02:41:59,800 --> 02:42:06,480 PAST YEARS. METHODS FOR 4407 02:42:06,480 --> 02:42:08,440 QUANTIFYING BEHAVIORS COMBINED 4408 02:42:08,440 --> 02:42:10,800 WITH ADVANCES IN BIOINFORMATICS 4409 02:42:10,800 --> 02:42:12,560 MADE THIS RESEARCH IN THIS AREA 4410 02:42:12,560 --> 02:42:14,120 MORE TRACTABLE AND READY FOR 4411 02:42:14,120 --> 02:42:19,320 ADDITIONAL WORK. NEXT SLIDE. SO 4412 02:42:19,320 --> 02:42:21,120 THERE'S SEVERAL RESEARCH AREAS 4413 02:42:21,120 --> 02:42:22,600 THAT WOULD BENEFIT FOR MORE 4414 02:42:22,600 --> 02:42:25,080 RESEARCH, THESE INCLUDE 4415 02:42:25,080 --> 02:42:25,840 UNDERSTANDING THE POTENTIAL 4416 02:42:25,840 --> 02:42:28,760 HARMS OF SOCIAL MEDIA AND YOUTH 4417 02:42:28,760 --> 02:42:31,920 MENTAL HEALTH AS WELL AS 4418 02:42:31,920 --> 02:42:33,200 INTERVENTIONS. WE WANT TO 4419 02:42:33,200 --> 02:42:33,880 UNDERSTAND WHETHER WE CAN USE 4420 02:42:33,880 --> 02:42:35,600 SOCIAL MEDIA AS A TOOL TO 4421 02:42:35,600 --> 02:42:36,920 IDENTIFY CHILDREN AT RISK FOR 4422 02:42:36,920 --> 02:42:39,400 PSYCHOPATHOLOGY. WE WANT TO BE 4423 02:42:39,400 --> 02:42:41,240 ABLE TO CHARACTERIZE THE ROLE OF 4424 02:42:41,240 --> 02:42:43,040 DIGITAL SOCIAL INTERACTIONS IN 4425 02:42:43,040 --> 02:42:44,080 YOUTH SOCIAL DEVELOPMENT AND 4426 02:42:44,080 --> 02:42:47,240 CONTRIBUTIONS TO RISK AND 4427 02:42:47,240 --> 02:42:48,680 RESILIENCE FOR PSYCHOPATHOLOGY. 4428 02:42:48,680 --> 02:42:49,960 WE NEED TO BUILD MORE 4429 02:42:49,960 --> 02:42:51,040 INFORMATION ON THE METHOD 4430 02:42:51,040 --> 02:42:52,960 LOGICAL AND ETHICAL 4431 02:42:52,960 --> 02:42:54,480 CONSIDERATIONS FOR RESEARCH ON 4432 02:42:54,480 --> 02:42:56,320 SOCIAL MEDIA BEHAVIORS AND 4433 02:42:56,320 --> 02:42:58,680 YOUTH. AND WE WANT TO UNDERSTAND 4434 02:42:58,680 --> 02:43:00,520 HOW SOCIAL MEDIA BEHAVIORS 4435 02:43:00,520 --> 02:43:02,320 INTERACT WITH THE EFFICACY AND 4436 02:43:02,320 --> 02:43:03,760 EFFECTIVENESS OF MENTAL HEALTH 4437 02:43:03,760 --> 02:43:11,520 INTERVENTIONS. SO THERE'S 4438 02:43:11,520 --> 02:43:12,600 SEVERAL ANTICIPATED OUTCOMES. 4439 02:43:12,600 --> 02:43:13,960 FIRST WEAPON HOPE TO BETTER 4440 02:43:13,960 --> 02:43:15,040 UNDERSTAND BIDIRECTIONAL 4441 02:43:15,040 --> 02:43:16,400 INFLUENCE OF SOCIAL MEDIA AND 4442 02:43:16,400 --> 02:43:18,240 MENTAL HEALTH. WE WANT TO BE 4443 02:43:18,240 --> 02:43:20,560 ABLE TO IDENTIFY YOUTH AT RISK 4444 02:43:20,560 --> 02:43:22,240 FOR NEGATIVE MENTAL HEALTH 4445 02:43:22,240 --> 02:43:23,520 OUTCOMES ASSOCIATED WITH SOCIAL 4446 02:43:23,520 --> 02:43:25,200 MEDIA USE AS WELL AS IDENTIFY 4447 02:43:25,200 --> 02:43:28,120 THE RISK OF PROTECTIVE FACTORS 4448 02:43:28,120 --> 02:43:28,920 THAT EVERYBODY IS AS MODIFIABLE 4449 02:43:28,920 --> 02:43:30,960 TARGETS FOR FUTURE 4450 02:43:30,960 --> 02:43:31,520 INTERVENTIONAL DEVELOPMENT 4451 02:43:31,520 --> 02:43:33,760 EFFORTS. FINALLY, WORK SUPPORTED 4452 02:43:33,760 --> 02:43:36,280 IN THIS CONCEPT COULD USED TO 4453 02:43:36,280 --> 02:43:39,560 GENERATE DEVELOPMENTALLY 4454 02:43:39,560 --> 02:43:40,560 INFORMED FINDINGS, ENABLE YOUTH 4455 02:43:40,560 --> 02:43:42,160 FAMILIES AN COMMUNITIES TO MAKE 4456 02:43:42,160 --> 02:43:43,480 HEALTHY DECISIONS ABOUT SOCIAL 4457 02:43:43,480 --> 02:43:45,800 MEDIA USE. WITH THAT I WOULD BE 4458 02:43:45,800 --> 02:43:47,800 HAPPY TO HEAR FEEDBACK AND 4459 02:43:47,800 --> 02:43:51,120 COMMENTS FROM COUNCIL. 4460 02:43:51,120 --> 02:43:54,040 >> THANK YOU, JULIA. I BELIEVE 4461 02:43:54,040 --> 02:43:55,760 DR.S LIGHTFOOT WERE ASKED TO 4462 02:43:55,760 --> 02:43:57,080 PROVIDE FEEDBACK ON THIS 4463 02:43:57,080 --> 02:44:01,400 PROPOSAL. MARGUERITA WOULD YOU 4464 02:44:01,400 --> 02:44:01,760 LIKE TO START? 4465 02:44:01,760 --> 02:44:03,400 >> I CAN ABSOLUTE WILL I GO 4466 02:44:03,400 --> 02:44:04,560 FIRST. THANK YOU. THANK YOU VERY 4467 02:44:04,560 --> 02:44:07,960 MUCH FOR THAT AS WELL. I REALLY 4468 02:44:07,960 --> 02:44:09,320 SUPPORTED AND EXCITED TO SEE 4469 02:44:09,320 --> 02:44:12,640 THIS WORK, OR THIS CONCEPT 4470 02:44:12,640 --> 02:44:13,800 SUPPORTING AND ENCOURAGING WORK 4471 02:44:13,800 --> 02:44:16,720 ON SOCIAL MEDIA AND YOUTH, 4472 02:44:16,720 --> 02:44:18,200 MAINLY ALL WE NEED TO DO IS LOOK 4473 02:44:18,200 --> 02:44:20,200 AT ADOLESCENT AND THE FACT THEY 4474 02:44:20,200 --> 02:44:21,320 ARE STARING AT THEIR PHONE ALL 4475 02:44:21,320 --> 02:44:22,280 DAY TO KNOW THIS KIND OF 4476 02:44:22,280 --> 02:44:25,280 RESEARCH IS NEEDED BUT WE ALSO 4477 02:44:25,280 --> 02:44:26,400 HAVE SEEN EMERGING LITERATURE 4478 02:44:26,400 --> 02:44:27,880 THAT SUGGESTS SOCIAL MEDIA HAS 4479 02:44:27,880 --> 02:44:29,800 AN IMPACT ON A HOST OF MENTAL 4480 02:44:29,800 --> 02:44:32,960 HEALTH OUTCOMES. AMONG THIS 4481 02:44:32,960 --> 02:44:33,800 POPULATION. INCLUDING DEPRESSION 4482 02:44:33,800 --> 02:44:35,520 BODY IMAGE DYSFUNCTION, THOSE 4483 02:44:35,520 --> 02:44:39,920 KINDS OF THINGS. I RATELY LIKED 4484 02:44:39,920 --> 02:44:41,480 AND THOUGHT IT WAS IMPORTANT TO 4485 02:44:41,480 --> 02:44:44,000 SEE THAT BIDIRECTIONALTY THAT'S 4486 02:44:44,000 --> 02:44:45,880 CRITICAL BECAUSE WE DONE KNOW 4487 02:44:45,880 --> 02:44:47,640 ENOUGH ABOUT THINGS LIKE SOCIAL 4488 02:44:47,640 --> 02:44:49,440 MEDIA CAUSE, PEOPLE TO BE 4489 02:44:49,440 --> 02:44:51,200 DEPRESSED OR DO DEPRESSED YOUNG 4490 02:44:51,200 --> 02:44:52,960 PEOPLE GO TO PARTICULAR 4491 02:44:52,960 --> 02:44:55,880 PARTICULAR TYPES OF SOCIAL MEDIA 4492 02:44:55,880 --> 02:44:57,640 PLATFORMS AND THAT WORSENS THEIR 4493 02:44:57,640 --> 02:44:58,640 DEPRESSION. I APPRECIATED THE 4494 02:44:58,640 --> 02:45:00,040 FOCUS ON BOTH RISK AND 4495 02:45:00,040 --> 02:45:04,480 PROTECTIVE FACTORS FOR SOCIAL 4496 02:45:04,480 --> 02:45:06,680 MEDIA USE. OFTENTIMES WE TALK 4497 02:45:06,680 --> 02:45:09,160 ABOUT RISK BUT ANYONE WHO 4498 02:45:09,160 --> 02:45:11,000 INTERACTS WITH ADOLESCENT KNOWS 4499 02:45:11,000 --> 02:45:15,160 SOCIAL MEDIA AND HOW YOUNG 4500 02:45:15,160 --> 02:45:17,080 PERSON ENGAGES WITH SOCIAL MEDIA 4501 02:45:17,080 --> 02:45:19,240 IS PART OF WHO THEY ARE. IT'S 4502 02:45:19,240 --> 02:45:21,800 PART OF THE IDENTITY. SO WE HAVE 4503 02:45:21,800 --> 02:45:22,600 OPPORTUNITIES TO LEVERAGE SOCIAL 4504 02:45:22,600 --> 02:45:25,080 MEDIA TO PROMOTE HEALTHY 4505 02:45:25,080 --> 02:45:26,920 BEHAVIORS AND PROMOTE MENTAL 4506 02:45:26,920 --> 02:45:28,480 HEALTH AND SO REALLY LOOKING AT 4507 02:45:28,480 --> 02:45:29,720 -- WE WANT TO ENSURE THAT WE 4508 02:45:29,720 --> 02:45:32,240 INCLUDE THAT AS WELL. I 4509 02:45:32,240 --> 02:45:33,240 APPRECIATE THAT WAS ALSO BROUGHT 4510 02:45:33,240 --> 02:45:34,280 UP BECAUSE WE TEND TO ONLY LOOK 4511 02:45:34,280 --> 02:45:39,840 AT THE RISK. I ALSO APPRECIATE 4512 02:45:39,840 --> 02:45:42,320 FOCUS ON ETHICS. I THINK THE 4513 02:45:42,320 --> 02:45:44,680 ETHICS OF SOCIAL MEDIA AND OUR 4514 02:45:44,680 --> 02:45:46,480 METHODS FOR STUDYING SOCIAL 4515 02:45:46,480 --> 02:45:48,280 MEDIA ARE COMPLICATED AND 4516 02:45:48,280 --> 02:45:50,840 COMPLEX SO REALLY INVESTIGATING 4517 02:45:50,840 --> 02:45:54,720 AND LOOK AT THAT IS IMPORTANT. I 4518 02:45:54,720 --> 02:45:56,640 REALLY ALSO APPRECIATED THE NEED 4519 02:45:56,640 --> 02:45:58,400 TO UNDERSTAND THE RELATIONSHIPS 4520 02:45:58,400 --> 02:46:00,240 AMONG SOCIAL MEDIA BEHAVIOR, 4521 02:46:00,240 --> 02:46:02,520 SOCIAL MEDIA ENGAGEMENT, SOCIAL 4522 02:46:02,520 --> 02:46:04,280 CONTEXT AND MENTAL HEALTH. AND 4523 02:46:04,280 --> 02:46:05,800 PARTICULARLY GIVEN TODAY'S 4524 02:46:05,800 --> 02:46:07,720 PRESENTATION, BY DR. MCLAUGHLIN, 4525 02:46:07,720 --> 02:46:09,800 ENSURING WE ARE ALSO LOOKING -- 4526 02:46:09,800 --> 02:46:11,120 ENSURING THIS EXAMINATION 4527 02:46:11,120 --> 02:46:12,280 INCLUDES SOCIAL SUPPORT AND 4528 02:46:12,280 --> 02:46:13,800 ENGAGEMENT SO THINGS LIKE THE 4529 02:46:13,800 --> 02:46:16,800 LEVEL OF ACTIVE OR PASSIVE 4530 02:46:16,800 --> 02:46:18,280 ENGAGEMENT SEEMS IMPORTANT. AND 4531 02:46:18,280 --> 02:46:18,920 WILL BE IMPORTANT MOVING 4532 02:46:18,920 --> 02:46:21,480 FORWARD. THE ONE THING I WOULD 4533 02:46:21,480 --> 02:46:23,640 ALSO COMMENT ON IS WE KNOW THE 4534 02:46:23,640 --> 02:46:25,520 SOCIAL MEDIA LANDSCAPE IS 4535 02:46:25,520 --> 02:46:26,240 CHANGING. OFTENTIMES VERY 4536 02:46:26,240 --> 02:46:27,360 QUICKLY FOR YOUNG PEOPLE. 4537 02:46:27,360 --> 02:46:29,000 THERE'S NEW PLATFORMS POPPING UP 4538 02:46:29,000 --> 02:46:32,000 ALL THE TIME. SO I THINK OUR 4539 02:46:32,000 --> 02:46:34,360 METHODS AND STUDIES REALLY NEED 4540 02:46:34,360 --> 02:46:37,600 TO TAKE INTO ACCOUNT AND LOOK AT 4541 02:46:37,600 --> 02:46:39,400 DIFFERENT THE BIGGER PICTURE OF 4542 02:46:39,400 --> 02:46:40,960 THE WHY, HOW THE WHERE AND THE 4543 02:46:40,960 --> 02:46:43,880 WHO WITH REGARDS TO USING SOCIAL 4544 02:46:43,880 --> 02:46:45,840 MEDIA AS OPPOSED TO JUST 4545 02:46:45,840 --> 02:46:47,720 FOCUSING ON A PARTICULAR 4546 02:46:47,720 --> 02:46:50,560 PLATFORM WHY ARE YOUNG PEOPLE 4547 02:46:50,560 --> 02:46:51,360 USING A PARTICULAR PLATFORM HOW 4548 02:46:51,360 --> 02:46:53,520 THEY ARE ENGAGING IN PARTICULAR 4549 02:46:53,520 --> 02:46:54,640 PLATFORMS WHAT ARE THEY GETTING 4550 02:46:54,640 --> 02:46:57,760 OUT WHAT ARE THE IMPACTS, VIDEO 4551 02:46:57,760 --> 02:47:00,280 VERSUS PICTURES VERSUS WORDS. 4552 02:47:00,280 --> 02:47:01,800 ALL THOSE THINGS NEED TO BE 4553 02:47:01,800 --> 02:47:03,200 IMPORTANT SO IT WILL BE 4554 02:47:03,200 --> 02:47:04,760 IMPORTANT FOR US TO ALSO LOOK AT 4555 02:47:04,760 --> 02:47:05,800 THAT I VERY MUCH SUPPORT THIS 4556 02:47:05,800 --> 02:47:10,960 AND THANK YOU FOR SHARING IT. 4557 02:47:10,960 --> 02:47:17,280 >> THANK YOU. NEXT UP WE HAVE 4558 02:47:17,280 --> 02:47:21,760 ANOTHER DISCUSSANT. PLEASE. 4559 02:47:21,760 --> 02:47:23,880 >> I FEEL SIMILARLY, THIS IS 4560 02:47:23,880 --> 02:47:25,160 VERY TIMELY, IF WE THINK ABOUT 4561 02:47:25,160 --> 02:47:29,160 THE RAPIDLY -- EVOLUTION OF 4562 02:47:29,160 --> 02:47:29,840 SOCIALIZATION ENVIRONMENT OF 4563 02:47:29,840 --> 02:47:34,960 YOUTH OVER THE LAST 30 YEARS, 40 4564 02:47:34,960 --> 02:47:36,000 YEARS 20 YEARS, 10 YEARS, 2 4565 02:47:36,000 --> 02:47:37,200 YEARS IT MAKES DIFFICULT TO KNOW 4566 02:47:37,200 --> 02:47:38,960 WHAT TO MAKE OF DEVELOPMENTAL 4567 02:47:38,960 --> 02:47:40,440 STUDIES FROM LONG AGO SO NEED TO 4568 02:47:40,440 --> 02:47:42,200 CONTINUALLY UPDATE AND BE NIMBLE 4569 02:47:42,200 --> 02:47:43,640 IN TRACKING THESE SOCIAL 4570 02:47:43,640 --> 02:47:45,840 ENVIRONMENTS INCLUDING SOCIAL 4571 02:47:45,840 --> 02:47:49,120 MEDIA IS VERY TIMELY STRONGLY 4572 02:47:49,120 --> 02:47:50,280 SUPPORT, I THINK I WANT TO 4573 02:47:50,280 --> 02:47:54,440 HIGHLIGHT ISSUES EVEN MORE. ONE 4574 02:47:54,440 --> 02:47:57,880 IS AS I LOOK AT THIS LITERATURE 4575 02:47:57,880 --> 02:47:59,000 REVIEW IN PREPARATION, AND 4576 02:47:59,000 --> 02:48:00,840 THERE'S META ANALYSES, THE 4577 02:48:00,840 --> 02:48:02,000 CORRELATION OF SOCIAL MEDIA WITH 4578 02:48:02,000 --> 02:48:03,760 MENTAL HEALTH PROBLEMS IS 4579 02:48:03,760 --> 02:48:05,320 BECOMING -- ON THE REALLY ALMOST 4580 02:48:05,320 --> 02:48:06,800 ESTABLISHED OR CERTAINLY 4581 02:48:06,800 --> 02:48:10,000 BECOMING VERY ESTABLISHED BASED 4582 02:48:10,000 --> 02:48:11,920 ON RECENT META ANALYSES BUT 4583 02:48:11,920 --> 02:48:14,240 THERE'S CLEAR GAP IN CAUSE OF 4584 02:48:14,240 --> 02:48:16,040 CAUSALITY SO I WANT TO EMPHASIZE 4585 02:48:16,040 --> 02:48:17,640 THAT. THE TWO ELEPHANTS IN THE 4586 02:48:17,640 --> 02:48:18,920 ROOM ARE CAUSALITY AND THEN THE 4587 02:48:18,920 --> 02:48:20,840 HEAVY RELIANCE ON SELF-REPORT. 4588 02:48:20,840 --> 02:48:22,520 SO I THINK YOU ARE RIGHT TO 4589 02:48:22,520 --> 02:48:24,360 FOCUS ON HOW CAN WE BETTER 4590 02:48:24,360 --> 02:48:26,520 MEASURE WHAT THEY ARE DOING ON 4591 02:48:26,520 --> 02:48:30,320 THE SOCIAL MEDIA AND BETTER 4592 02:48:30,320 --> 02:48:32,440 MEASURE PSYCHOPATHOLOGY AS WELL. 4593 02:48:32,440 --> 02:48:33,480 TWO CRITICAL ISSUES YOU ARE 4594 02:48:33,480 --> 02:48:36,280 RIGHT TO EMPHASIZE AND I 4595 02:48:36,280 --> 02:48:38,760 UNDERSCORE. I WOULD ALSO 4596 02:48:38,760 --> 02:48:41,000 HIGHLIGHT AS YOU DEVELOP THE 4597 02:48:41,000 --> 02:48:44,560 RELEVANCE OF THE ACTIVITY THAT 4598 02:48:44,560 --> 02:48:46,880 ALSO NOTED. ONE ACTIVITY 4599 02:48:46,880 --> 02:48:48,440 FRIENDLY CLOSE CONNECTION WITH A 4600 02:48:48,440 --> 02:48:50,680 FRIEND IS VERY DIFFERENT FROM 4601 02:48:50,680 --> 02:48:53,800 BEING SUBJECTED TO GROUP NOISE 4602 02:48:53,800 --> 02:48:56,040 AND GROUP ACTIVITY AND WHAT USES 4603 02:48:56,040 --> 02:48:58,680 ARE HEALTHY OR UNHEALTHY AS YOU 4604 02:48:58,680 --> 02:49:00,280 IDENTIFY HERE IS IMPORTANT BUT 4605 02:49:00,280 --> 02:49:01,760 FOCUSING ON CONTENT AND TYPE OF 4606 02:49:01,760 --> 02:49:04,440 USE. THEN THIS ISSUE OF 4607 02:49:04,440 --> 02:49:06,520 MODERATORS AND AGAIN ALSO ECHO 4608 02:49:06,520 --> 02:49:09,560 THAT KATIE MCLAUGHLIN THIS 4609 02:49:09,560 --> 02:49:11,160 MORNING, WHAT ABOUT EXERCISE, 4610 02:49:11,160 --> 02:49:13,760 PARENTING ALL THESE DIFFERENT 4611 02:49:13,760 --> 02:49:15,400 MODERATORS THAT MAY IMMUNIZE 4612 02:49:15,400 --> 02:49:16,760 SOME CHILDREN INOCULATE SOME 4613 02:49:16,760 --> 02:49:19,520 AGAINST THE RISKS WHEREAS OTHERS 4614 02:49:19,520 --> 02:49:21,200 ARE CLEARLY AT RISK SO THERE'S 4615 02:49:21,200 --> 02:49:22,480 TREMENDOUS AMOUNT TO DO HERE. 4616 02:49:22,480 --> 02:49:24,520 ONE QUESTION TO KEEP -- THAT I 4617 02:49:24,520 --> 02:49:27,480 STRUCK ME, THINKING ABOUT THIS 4618 02:49:27,480 --> 02:49:29,800 IS THERE'S ENTIRE LITERATURE 4619 02:49:29,800 --> 02:49:32,680 AROUND THINGS SO CALLED 4620 02:49:32,680 --> 02:49:33,520 ADDICTION MEDIA ADDICTION OR 4621 02:49:33,520 --> 02:49:36,400 SCREEN ADDICTION, SO MAYBE 4622 02:49:36,400 --> 02:49:37,480 CLARIFY WHETHER THAT IS INTENDED 4623 02:49:37,480 --> 02:49:39,040 TO BE SWEPT UNDER THIS OR NOT, 4624 02:49:39,040 --> 02:49:41,360 REALLY FOCUSING ONLY ON SOCIAL 4625 02:49:41,360 --> 02:49:42,840 MEDIA OR ON SCREEN USE 4626 02:49:42,840 --> 02:49:43,960 GENERALLY. I DON'T HAVE A 4627 02:49:43,960 --> 02:49:46,240 RECOMMENDATION THERE BUT JUST 4628 02:49:46,240 --> 02:49:48,800 PUT CLEAR BOUNDARY ON THIS. 4629 02:49:48,800 --> 02:49:51,640 SIMILARLY THERE IS OBVIOUSLY 4630 02:49:51,640 --> 02:49:53,400 EVEN WE HEARD TODAY, TREMENDOUS 4631 02:49:53,400 --> 02:49:55,440 INTEREST IN USING DIGITAL MEDIA 4632 02:49:55,440 --> 02:49:57,760 TO ENHANCE MENTAL HEALTH 4633 02:49:57,760 --> 02:49:58,440 INTERVENTION AND CLINICAL TRIALS 4634 02:49:58,440 --> 02:50:00,440 AND SO ON. IS THAT BEING SWEPT 4635 02:50:00,440 --> 02:50:02,880 INTO THIS AS WELL? OR DO YOU 4636 02:50:02,880 --> 02:50:04,640 WANT TO BRACKET THAT AS SEPARATE 4637 02:50:04,640 --> 02:50:09,000 CATEGORY? SO THE BOUNDARIES OF 4638 02:50:09,000 --> 02:50:10,600 THIS INITIATIVE AND HOW MUCH OF 4639 02:50:10,600 --> 02:50:13,720 THIS UNIVERSE TO SWEEP UNDER IT 4640 02:50:13,720 --> 02:50:17,760 NEEDS TO BE CLARIFIED. DEPENDING 4641 02:50:17,760 --> 02:50:19,680 WHETHER INTERVENTIONS, ISSUES 4642 02:50:19,680 --> 02:50:21,840 NIMH HAS. BUT VERY GOOD JULIA. 4643 02:50:21,840 --> 02:50:25,800 THIS IS REALLY NECESSARY. 4644 02:50:25,800 --> 02:50:27,960 >> THANKS TO BOTH COMMENTERS. 4645 02:50:27,960 --> 02:50:29,600 MARGUERITA AND JOEL. ANY 4646 02:50:29,600 --> 02:50:30,880 COMMENTS OR QUESTIONS FROM THE 4647 02:50:30,880 --> 02:50:33,680 REST OF THE COMMITTEE? 4648 02:50:33,680 --> 02:50:35,200 >> PAT HAS HER HAND UP. 4649 02:50:35,200 --> 02:50:41,200 >> GO AHEAD. PATRICIA. 4650 02:50:41,200 --> 02:50:45,320 >> THANK YOU, VERY MUCH. I AM 4651 02:50:45,320 --> 02:50:46,920 ALSO INCREDIBLY ENTHUSIASTIC 4652 02:50:46,920 --> 02:50:49,760 ABOUT THIS PROPOSAL. AND THE ONE 4653 02:50:49,760 --> 02:50:52,240 AREA THAT I WOULD LIKE TO SEE 4654 02:50:52,240 --> 02:50:54,040 PROMOTED A LITTLE BIT MORE WOULD 4655 02:50:54,040 --> 02:50:56,800 BE THE CONSIDERATION OF THE 4656 02:50:56,800 --> 02:50:58,560 ETHICS. JUST BECAUSE WE CAN 4657 02:50:58,560 --> 02:51:00,080 COLLECT SOME DATA DOES THAT MEAN 4658 02:51:00,080 --> 02:51:03,880 WE OUGHT TO COLLECT THE DATA, IS 4659 02:51:03,880 --> 02:51:07,120 ONE CONCERN. BUT MY BASIC 4660 02:51:07,120 --> 02:51:12,200 CONCERN IS, THAT THE YOUTH MAY 4661 02:51:12,200 --> 02:51:13,640 OR MAY NOT UNDERSTAND WHAT THEY 4662 02:51:13,640 --> 02:51:17,760 ARE BEING ASKED TO TURN OVER OVY 4663 02:51:17,760 --> 02:51:19,320 ALLOWING ACCESS TO THEIR PHONE 4664 02:51:19,320 --> 02:51:22,080 OR THEIR SOCIAL MEDIA ACCOUNTS 4665 02:51:22,080 --> 02:51:25,440 OR -- AND WHAT THE POTENTIAL 4666 02:51:25,440 --> 02:51:28,840 CONSEQUENCES ARE OF OTHER PEOPLE 4667 02:51:28,840 --> 02:51:34,000 BEING ABLE TO FOLLOW THEM IN 4668 02:51:34,000 --> 02:51:36,280 THIS WAY. SO I THINK THAT AS WE 4669 02:51:36,280 --> 02:51:38,160 GO AHEAD AND TRY TO DEVELOP 4670 02:51:38,160 --> 02:51:41,320 THESE STUDIES, HOW WE GO ABOUT 4671 02:51:41,320 --> 02:51:46,480 GETTING INFORMED CONSENT AND HOW 4672 02:51:46,480 --> 02:51:50,640 WE GO ABOUT PROTECTING THE DATA 4673 02:51:50,640 --> 02:51:55,960 ARE NEW ISSUES THAT I THINK 4674 02:51:55,960 --> 02:51:57,760 DESERVE ADDED ATTENTION FROM OUR 4675 02:51:57,760 --> 02:52:00,280 TRADITIONAL ADULT FOCUSED 4676 02:52:00,280 --> 02:52:03,120 ACTIVITIES. 4677 02:52:03,120 --> 02:52:06,400 >> THANK YOU, PATRICIA. THANK 4678 02:52:06,400 --> 02:52:08,680 YOU. WE APPRECIATE THE FEEDBACK. 4679 02:52:08,680 --> 02:52:10,680 AND JULIA AND OTHERS WILL 4680 02:52:10,680 --> 02:52:12,040 INCORPORATE IT AS THEY MOVE 4681 02:52:12,040 --> 02:52:12,640 FORWARD WITH PLANNING THAT 4682 02:52:12,640 --> 02:52:17,760 INITIATIVE. NEXT UP WE HAVE DR. 4683 02:52:17,760 --> 02:52:22,520 LAURA ROLAND, GERIATRIC AND 4684 02:52:22,520 --> 02:52:24,080 AGING PROCESSES RESEARCH BRANCH 4685 02:52:24,080 --> 02:52:26,680 DIVISION OF TRANSLATIONAL 4686 02:52:26,680 --> 02:52:27,880 RESEARCH, SCHIZOPHRENIA AND 4687 02:52:27,880 --> 02:52:29,560 RELATED DISORDERS DURING MID TO 4688 02:52:29,560 --> 02:52:29,960 LATE LIFE. 4689 02:52:29,960 --> 02:52:33,280 >> THANK YOU. I WANT TO THANK MY 4690 02:52:33,280 --> 02:52:37,680 COLLEAGUE DR. EVANSS. SO THIS 4691 02:52:37,680 --> 02:52:40,480 CONCEPT ALIGNS WITH OUR NIMH 4692 02:52:40,480 --> 02:52:42,280 STRATEGIC PLAN GOAL NUMBER 2. 4693 02:52:42,280 --> 02:52:45,640 EXAMINE MENTAL ILLNESS 4694 02:52:45,640 --> 02:52:46,760 TRAJECTORIES ACROSS THE LIFE 4695 02:52:46,760 --> 02:52:48,720 SPAN. ONE OF THE PROBLEMS IS 4696 02:52:48,720 --> 02:52:50,200 THAT WE HAVE A PAUCITY OF 4697 02:52:50,200 --> 02:52:52,680 RESEARCH ON SCHIZOPHRENIA, AND 4698 02:52:52,680 --> 02:52:54,600 RELATED PSYCHOTIC DISORDERS IN 4699 02:52:54,600 --> 02:52:58,680 MID TO LATE LIFE. AND THIS HAS 4700 02:52:58,680 --> 02:53:01,680 IMPACTED THE EMERGENCE OF NEW 4701 02:53:01,680 --> 02:53:03,960 INTERVENTIONS AND PREVENTATIVE 4702 02:53:03,960 --> 02:53:06,120 STRATEGIES. SO THE OVERARCHING 4703 02:53:06,120 --> 02:53:07,640 GOAL OF THIS CONCEPT IS TO 4704 02:53:07,640 --> 02:53:09,800 ADVANCE TRANSLATIONAL RESEARCH 4705 02:53:09,800 --> 02:53:12,400 IN THIS CLINICAL POPULATION. 4706 02:53:12,400 --> 02:53:14,560 WITH THE HOPE TO AXEL RATE 4707 02:53:14,560 --> 02:53:17,760 DEVELOPMENT OF PREVENTION AND 4708 02:53:17,760 --> 02:53:19,560 INTERVENTION EFFORTS. NEXT SLIDE 4709 02:53:19,560 --> 02:53:21,440 PLEASE. SO THE MAJORITY OF 4710 02:53:21,440 --> 02:53:22,800 PEOPLE LIVING WITH SCHIZOPHRENIA 4711 02:53:22,800 --> 02:53:25,120 AND RELATED PSYCHOTIC DISORDERS 4712 02:53:25,120 --> 02:53:26,760 ARE IN THE MID TO LATE LIFE. 4713 02:53:26,760 --> 02:53:28,840 THAT'S THE MIDDLE FIGURE. THIS 4714 02:53:28,840 --> 02:53:30,320 INCLUDES THOSE WHO HAVE AN 4715 02:53:30,320 --> 02:53:33,720 ILLNESS ONSET AFTER THE AGE OF 4716 02:53:33,720 --> 02:53:35,760 35, 40, THAT IS THE LEFT FIGURE, 4717 02:53:35,760 --> 02:53:37,880 AND THOSE AGING WITH ILLNESS. 4718 02:53:37,880 --> 02:53:40,280 THIS ILLNESS IS AMONG THE TOP 15 4719 02:53:40,280 --> 02:53:42,160 LEADING CAUSES OF DISABILITY 4720 02:53:42,160 --> 02:53:45,800 WORLDWIDE. THE HIGHEST BURDEN OF 4721 02:53:45,800 --> 02:53:46,840 DISEASE OCCURS DURING MID LIFE 4722 02:53:46,840 --> 02:53:50,400 OUTLINED IN THE RIGHT FIGURE. 4723 02:53:50,400 --> 02:53:51,080 UNFORTUNATELY THIS POPULATION 4724 02:53:51,080 --> 02:53:53,640 HAS A SHORTER LIFE SPAN AND 4725 02:53:53,640 --> 02:53:54,320 GREATER MORBIDITY THAN THE 4726 02:53:54,320 --> 02:53:57,080 GENERAL POPULATION. AND WE 4727 02:53:57,080 --> 02:53:57,800 CURRENTLY HAVE POOR 4728 02:53:57,800 --> 02:53:59,760 UNDERSTANDING OF THE MECHANISMS 4729 02:53:59,760 --> 02:54:01,760 UNDERLYING ILLNESS EMERGENCE, 4730 02:54:01,760 --> 02:54:05,120 TRAJECTORIES AND OUTCOMES DURING 4731 02:54:05,120 --> 02:54:10,360 LATER LIFE. NEXT SLIDE PLEASE. 4732 02:54:10,360 --> 02:54:12,240 SOME POTENTIAL RESEARCH AREAS 4733 02:54:12,240 --> 02:54:15,880 INCLUDE BUT ARE NOT LIMITED TO 4734 02:54:15,880 --> 02:54:17,120 PHENOMMOLOGY, ETIOLOGY AND 4735 02:54:17,120 --> 02:54:19,760 PATHOPHYSIOLOGY OF FIRST EPISODE 4736 02:54:19,760 --> 02:54:21,760 PSYCHOSIS THAT EMERGES MID TO 4737 02:54:21,760 --> 02:54:23,120 LATE LIFE. THE UNDERLYING 4738 02:54:23,120 --> 02:54:25,040 MECHANISMS AND TRAJECTORIES OF 4739 02:54:25,040 --> 02:54:27,040 PSYCHOSIS, NEGATIVE SYMPTOMS 4740 02:54:27,040 --> 02:54:30,880 COGNITION, SOCIAL COGNITION AND 4741 02:54:30,880 --> 02:54:32,040 EVERY DAY FUNCTIONING MID TO 4742 02:54:32,040 --> 02:54:34,080 LATE LIFE. UNDERLYING BIOLOGICAL 4743 02:54:34,080 --> 02:54:36,160 AND OTHER MECHANISMS SUCH AS 4744 02:54:36,160 --> 02:54:37,080 BEHAVIORAL AND SOCIAL 4745 02:54:37,080 --> 02:54:38,320 DETERMINANTS OF HEALTH FOR THE 4746 02:54:38,320 --> 02:54:40,520 INCREASE RISK OF DEMENTIA IN 4747 02:54:40,520 --> 02:54:43,600 THIS POPULATION. ACCELERATED 4748 02:54:43,600 --> 02:54:46,360 BIOLOGICAL AGING THAT MAY 4749 02:54:46,360 --> 02:54:49,320 INFLUENCE PSYCHOPATHOLOGY 4750 02:54:49,320 --> 02:54:50,400 PREMATURE MORBIDITY AND 4751 02:54:50,400 --> 02:54:52,560 MORTALITY IN THIS POPULATION. 4752 02:54:52,560 --> 02:54:53,800 AND THE IDENTIFICATION OF 4753 02:54:53,800 --> 02:54:55,080 TREATMENT TARGETS AND 4754 02:54:55,080 --> 02:54:56,280 DEVELOPMENT OF NOVEL 4755 02:54:56,280 --> 02:54:58,600 INTERVENTIONS TO IMPROVE HEALTH 4756 02:54:58,600 --> 02:55:04,240 OUTCOMES. SO RESEARCH NEEDS AND 4757 02:55:04,240 --> 02:55:06,040 EXPECTED OUTCOMES. AS I STATED 4758 02:55:06,040 --> 02:55:08,400 PREVIOUSLY OLDER ADULTS ARE 4759 02:55:08,400 --> 02:55:10,520 UNDER-REPRESENTED IN PSYCHOSIS 4760 02:55:10,520 --> 02:55:13,760 RESEARCH. HAVING TARGETING -- 4761 02:55:13,760 --> 02:55:15,440 TARGETED FUNDING OPPORTUNITIES 4762 02:55:15,440 --> 02:55:16,800 ANNOUNCEMENTS IS GOING TO 4763 02:55:16,800 --> 02:55:17,760 ENCOURAGE RESEARCH IN THIS 4764 02:55:17,760 --> 02:55:19,480 POPULATION. THERE'S ALSO A NEED 4765 02:55:19,480 --> 02:55:21,800 FOR RESEARCH EXAMINING 4766 02:55:21,800 --> 02:55:22,840 UNDERSTUDIED GROUPS WITHIN THIS 4767 02:55:22,840 --> 02:55:25,000 CLINICAL POPULATION. THAT 4768 02:55:25,000 --> 02:55:28,000 INCLUDES WOMEN AND MINORITIZED 4769 02:55:28,000 --> 02:55:30,280 GROUPS. SO WITH ADDITIONAL 4770 02:55:30,280 --> 02:55:32,200 RESEARCH WE WOULD IMPROVEMENT 4771 02:55:32,200 --> 02:55:33,880 OUR UNDERSTANDING OF MECHANISMS 4772 02:55:33,880 --> 02:55:36,440 UNDERLYING THE ILLNESS AND MID 4773 02:55:36,440 --> 02:55:39,680 TO LATE LIFE AND THEREFORE HELP 4774 02:55:39,680 --> 02:55:41,400 ACCELERATE DEVELOPMENT OF NEW 4775 02:55:41,400 --> 02:55:43,320 INTERVENTIONS AND PREVENTATIVE 4776 02:55:43,320 --> 02:55:45,120 EFFORTS. THANK YOU FOR YOUR 4777 02:55:45,120 --> 02:55:45,760 ATTENTION. HAPPY TO ANSWER ANY 4778 02:55:45,760 --> 02:55:50,280 QUESTIONS. 4779 02:55:50,280 --> 02:55:51,120 >> THANK YOU VERY MUCH, LAURA 4780 02:55:51,120 --> 02:55:56,520 AND FOR DISCUSSANTS WE HAVE DR. 4781 02:55:56,520 --> 02:55:59,360 SOFIA AND KILL BORN. AMY START 4782 02:55:59,360 --> 02:55:59,600 US A OFF. 4783 02:55:59,600 --> 02:56:01,400 >> YES, I CAN BE BRIEF BECAUSE 4784 02:56:01,400 --> 02:56:04,440 I'M HIGHLY SUPPORTIVE OF THIS 4785 02:56:04,440 --> 02:56:06,120 CONCEPT AND I THINK IT ADDRESSES 4786 02:56:06,120 --> 02:56:08,600 A VERY IMPORTANT POPULATION BOTH 4787 02:56:08,600 --> 02:56:11,440 CLINICALLY AND IN TERMS OF 4788 02:56:11,440 --> 02:56:12,880 QUESTIONS AND MYSTERIES WE HAVE 4789 02:56:12,880 --> 02:56:18,240 ABOUT PERSISTENT PSYCHOSIS. TWO 4790 02:56:18,240 --> 02:56:19,400 ADDITIONAL POINTS TO MAKE IS 4791 02:56:19,400 --> 02:56:20,880 THAT IF WE CAN GAIN GREATER 4792 02:56:20,880 --> 02:56:21,800 INSIGHT INTO WHAT IS UNIQUE 4793 02:56:21,800 --> 02:56:25,760 ABOUT THE MECHANISMS THAT OCCUR 4794 02:56:25,760 --> 02:56:28,080 IN PEOPLE WHO ARE EXPERIENCING 4795 02:56:28,080 --> 02:56:29,800 INITIAL ONSET OF PSYCHOSIS LATER 4796 02:56:29,800 --> 02:56:32,520 IN LIFE, THAT WILL HIGHLY -- 4797 02:56:32,520 --> 02:56:35,160 THAT WE HIGHLY LIKELY TO YIELD 4798 02:56:35,160 --> 02:56:37,440 NOVEL WAYS OF THINKING WHAT IS 4799 02:56:37,440 --> 02:56:39,200 HAPPENING IN THE MORE 4800 02:56:39,200 --> 02:56:40,560 TRADITIONAL DEVELOPMENTAL LIFE 4801 02:56:40,560 --> 02:56:42,800 SPAN OR TRADITIONAL 4802 02:56:42,800 --> 02:56:43,480 DEVELOPMENTAL PICTURE THAT WE 4803 02:56:43,480 --> 02:56:45,440 SEE IN PSYCHOSIS, WHAT 4804 02:56:45,440 --> 02:56:48,920 MECHANISMS ARE SIMILAR, WHAT ARE 4805 02:56:48,920 --> 02:56:50,520 DISTINCT, AGAIN SORTING OUT 4806 02:56:50,520 --> 02:56:53,520 THEIR INFLUENCE OF ENVIRONMENT, 4807 02:56:53,520 --> 02:56:54,640 DRUG EXPOSURE, ET CETERA. THE 4808 02:56:54,640 --> 02:56:56,000 SECOND POINT I WOULD MAKE IS I 4809 02:56:56,000 --> 02:56:57,440 THINK THIS KIND OF RESEARCH 4810 02:56:57,440 --> 02:57:00,560 OFFERS SOME VERY INTERESTING 4811 02:57:00,560 --> 02:57:05,160 OPPORTUNITIES TO PROBE INTO THE 4812 02:57:05,160 --> 02:57:06,120 RELATIONSHIP OF BETWEEN 4813 02:57:06,120 --> 02:57:07,040 PSYCHOSIS AND OTHER SERIOUS 4814 02:57:07,040 --> 02:57:09,800 MENTAL DISORDERS AND BRAIN 4815 02:57:09,800 --> 02:57:11,520 AGING. WE KNOW THAT THERE STARTS 4816 02:57:11,520 --> 02:57:16,120 TO BE DISREGULATIONS IN CELLULAR 4817 02:57:16,120 --> 02:57:17,800 PLASTICITY PROCESSES OF THE 4818 02:57:17,800 --> 02:57:19,720 BRAIN ADVANCES IN AGE, LIKELY 4819 02:57:19,720 --> 02:57:22,920 RELATED TO SENSORY NOISE AND 4820 02:57:22,920 --> 02:57:23,880 UNDERSTANDING THOSE KINDS OF 4821 02:57:23,880 --> 02:57:24,920 MECHANISMS AND HOW THEY ARE 4822 02:57:24,920 --> 02:57:27,600 APPEARING IN PSYCHOSIS SPECTRUM 4823 02:57:27,600 --> 02:57:29,080 ILLNESSES MAY AGAIN GIVE 4824 02:57:29,080 --> 02:57:31,960 ADDITIONAL INSIGHT INTO THE 4825 02:57:31,960 --> 02:57:37,000 ILLNESS PHENOTYPE MORE BROADLY. 4826 02:57:37,000 --> 02:57:40,120 >> THANK YOU SOFIA. AMY. 4827 02:57:40,120 --> 02:57:41,840 >> THANKS FOR THE OPPORTUNITY TO 4828 02:57:41,840 --> 02:57:42,920 REVIEW. THIS IS REALLY 4829 02:57:42,920 --> 02:57:44,240 INTERESTING AND I AGREE WITH 4830 02:57:44,240 --> 02:57:48,280 WHAT SOFIA HAS SAID. TO ADD TO 4831 02:57:48,280 --> 02:57:50,440 WHAT SHE'S COVERED, I'M VERY 4832 02:57:50,440 --> 02:57:51,720 INTERESTED IN AND CURIOUS WHAT 4833 02:57:51,720 --> 02:57:54,280 KINDS OF MECHANISMS COULD BE 4834 02:57:54,280 --> 02:57:55,840 STUDIED AROUND SOCIAL 4835 02:57:55,840 --> 02:57:57,120 DETERMINANTS IN PARTICULAR FROM 4836 02:57:57,120 --> 02:57:59,480 A REAL WORLD EXPERIENCE WE HAVE 4837 02:57:59,480 --> 02:58:01,200 SEEN AT LEAST IN SOME TREATMENT 4838 02:58:01,200 --> 02:58:03,040 SETTINGS, THERE IS A NATIONAL 4839 02:58:03,040 --> 02:58:05,760 STUDY THAT CAME OUT THAT LOOKED 4840 02:58:05,760 --> 02:58:09,480 AT THE FACT THAT THERE IS A PUSH 4841 02:58:09,480 --> 02:58:11,360 TO DEIMPLEMENT SOME 4842 02:58:11,360 --> 02:58:12,920 OVERPRESCRIBING OF 4843 02:58:12,920 --> 02:58:13,680 ANTI-PSYCHOTIC IN NURSING HOMES 4844 02:58:13,680 --> 02:58:17,040 FOR EXAMPLE HAS LED TO AN 4845 02:58:17,040 --> 02:58:18,280 INCREASE UNINTENDED INCREASE OF 4846 02:58:18,280 --> 02:58:19,560 PRESCRIPTIONS FOR MEDICATIONS 4847 02:58:19,560 --> 02:58:21,040 THAT MAY NOT BE THE BEST THINGS 4848 02:58:21,040 --> 02:58:22,920 FOR PEOPLE AND I THINK WE NEED 4849 02:58:22,920 --> 02:58:24,160 MECHANISMS STUDIES BECAUSE WE 4850 02:58:24,160 --> 02:58:25,680 DON'T KNOW WHAT IS HAPPENING 4851 02:58:25,680 --> 02:58:27,400 WITH THESE INDIVIDUALS AND WHAT 4852 02:58:27,400 --> 02:58:29,440 IS GOING ON IN THE NURSING HOMES 4853 02:58:29,440 --> 02:58:32,200 AND THEY HIGHLY VULNERABLE TO 4854 02:58:32,200 --> 02:58:33,120 GETTING TREATMENT INAPPROPRIATE 4855 02:58:33,120 --> 02:58:35,440 TREATMENT AND NOT THE RIGHT 4856 02:58:35,440 --> 02:58:36,600 TREATMENT DEPENDING ON ETIOLOGY. 4857 02:58:36,600 --> 02:58:38,040 SO THIS WORK AROUND MECHANISMS 4858 02:58:38,040 --> 02:58:39,920 IS GOING TO BE REALLY IMPORTANT 4859 02:58:39,920 --> 02:58:44,160 FROM NOT JUST A BIOLOGICAL 4860 02:58:44,160 --> 02:58:46,800 NATURE BUT ALSO SOCIO LOGICAL 4861 02:58:46,800 --> 02:58:48,400 NATURE AS WELL, WHAT ARE SOME OF 4862 02:58:48,400 --> 02:58:51,880 THE EXPERIENCES PEOPLE HAD WITH 4863 02:58:51,880 --> 02:58:54,160 PRIOR TREATMENT, WHAT WILL THEIR 4864 02:58:54,160 --> 02:58:55,560 SITUATION HAS BEEN, SORT OF LIFE 4865 02:58:55,560 --> 02:58:57,440 JOURNEY WITH HOMELESSNESS AND 4866 02:58:57,440 --> 02:58:59,200 ALSO BEING INSTITUTIONALIZED 4867 02:58:59,200 --> 02:59:01,880 CARE. I WOULD BE INTERESTED IN 4868 02:59:01,880 --> 02:59:03,480 LOOKING AT LOT OF MECHANISMS AT 4869 02:59:03,480 --> 02:59:05,360 THESE MULTIPLE LEVELS SO REALLY 4870 02:59:05,360 --> 02:59:06,440 EXCITED ABOUT THIS AND LOOK 4871 02:59:06,440 --> 02:59:07,520 FORWARD TO SEEING IT HAPPEN. 4872 02:59:07,520 --> 02:59:10,240 THANKS. 4873 02:59:10,240 --> 02:59:12,840 >> THANK YOU, AMY AND SOFIA. ANY 4874 02:59:12,840 --> 02:59:17,040 QUESTIONS OR COMMENTS FROM OTHER 4875 02:59:17,040 --> 02:59:19,800 MEMBERS OF THE COMMITTEE? 4876 02:59:19,800 --> 02:59:21,160 >> PATRICIA AND MARJORIE HAVE 4877 02:59:21,160 --> 02:59:24,040 THEIR HANDS UP. 4878 02:59:24,040 --> 02:59:28,800 >> START WITH YOU PAT. 4879 02:59:28,800 --> 02:59:31,400 >> I THINK THIS IS EXCEPTIONALLY 4880 02:59:31,400 --> 02:59:32,880 INTERESTING AND IMPORTANT AREA. 4881 02:59:32,880 --> 02:59:38,000 I WAS JUST WONDERING HOW STUDY 4882 02:59:38,000 --> 02:59:40,920 IN THIS AREA WOULD BE ABLE TO 4883 02:59:40,920 --> 02:59:42,960 IDENTIFY AND RECRUIT PEOPLE WHO 4884 02:59:42,960 --> 02:59:47,960 ARE NOT ALREADY ENGAGED IN 4885 02:59:47,960 --> 02:59:48,200 TREATMENT? 4886 02:59:48,200 --> 02:59:49,760 >> GOOD QUESTION. DO WE HAVE AN 4887 02:59:49,760 --> 02:59:53,560 ANSWER? NOT SURE WE HAVE A 4888 02:59:53,560 --> 02:59:57,040 RESPONSE TO THAT. 4889 02:59:57,040 --> 02:59:59,080 >> DO YOU WANT ME TO ANSWER? 4890 02:59:59,080 --> 03:00:01,280 FROM MY UNDERSTANDING WE HAD A 4891 03:00:01,280 --> 03:00:03,800 WORK SHOP ON THIS SUBJECT SO 4892 03:00:03,800 --> 03:00:05,520 THERE ARE PEOPLE THAT HAVE 4893 03:00:05,520 --> 03:00:06,920 ILLNESS ONSET LATE IN LIFE SO 4894 03:00:06,920 --> 03:00:11,360 THEY HAVE NOT HAD TREATMENT. 4895 03:00:11,360 --> 03:00:13,720 THEY ARE SOMEWHAT RARE SO ABOUT 4896 03:00:13,720 --> 03:00:16,120 25% HAVE THEIR ILLNESS ONSET AT 4897 03:00:16,120 --> 03:00:19,000 AGE 35 AND BEYOND. SO THERE IS 4898 03:00:19,000 --> 03:00:20,320 THAT GROUP BUT YOU ARE RIGHT WE 4899 03:00:20,320 --> 03:00:22,640 NEED TO STUDY PEOPLE WHO ARE 4900 03:00:22,640 --> 03:00:24,280 ALREADY IN CARE AND AGING WITH 4901 03:00:24,280 --> 03:00:27,560 ILLNESS. SO THAT IS THE CONCEPT 4902 03:00:27,560 --> 03:00:29,200 COVERS, IT IS BROAD. 4903 03:00:29,200 --> 03:00:31,720 >> I WAS POTENTIALLY THINKING 4904 03:00:31,720 --> 03:00:34,560 ABOUT PEOPLE WHO MAY HAVE HAD AN 4905 03:00:34,560 --> 03:00:36,480 ONSET AT TRADITIONAL AGE BUT 4906 03:00:36,480 --> 03:00:38,280 HAVE BEEN KEPT AT HOME OR LIVED 4907 03:00:38,280 --> 03:00:39,480 IN A COMMUNITY WITHOUT BEING 4908 03:00:39,480 --> 03:00:41,360 TREATED. 4909 03:00:41,360 --> 03:00:45,880 >> RIGHT. SO THAT IS ANOTHER 4910 03:00:45,880 --> 03:00:49,440 GROUP TOO. INTERESTINGLY THERE 4911 03:00:49,440 --> 03:00:53,760 ARE POPULATIONS WORLDWIDE WHO 4912 03:00:53,760 --> 03:00:56,200 HAVE TRADITIONAL ILLNESS ONSET 4913 03:00:56,200 --> 03:00:57,400 EARLIER IN LIFE AND HAVEN'T BEEN 4914 03:00:57,400 --> 03:00:59,000 TREATED. SO THAT SOMETHING WE 4915 03:00:59,000 --> 03:01:01,560 ARE THINKING ABOUT. 4916 03:01:01,560 --> 03:01:04,040 >> I HAVE A COMMENT AS WELL ON 4917 03:01:04,040 --> 03:01:05,800 THAT. I WILL JUMP IN HERE IF YOU 4918 03:01:05,800 --> 03:01:06,280 DON'T MIND JOSH. 4919 03:01:06,280 --> 03:01:07,440 >> GO AHEAD. 4920 03:01:07,440 --> 03:01:10,960 >> VERY BRIEFLY, IF YOU SET UP 4921 03:01:10,960 --> 03:01:12,960 ONLINE RESEARCH PROJECTS, YOU 4922 03:01:12,960 --> 03:01:14,680 CAPTURE AN INTERESTING GROUP OF 4923 03:01:14,680 --> 03:01:17,720 INDIVIDUALS WHO HAVE NOT BEEN 4924 03:01:17,720 --> 03:01:21,440 ENGAGED IN TRADITIONAL MEDICAL 4925 03:01:21,440 --> 03:01:21,880 TREATMENT SETTINGS. 4926 03:01:21,880 --> 03:01:23,440 >> THANKS FOR THAT INSIGHT. 4927 03:01:23,440 --> 03:01:25,800 MARJORIE. 4928 03:01:25,800 --> 03:01:30,200 >> I TOO VERY ENTHUSIASTIC ABOUT 4929 03:01:30,200 --> 03:01:32,600 THIS CONCEPT AND I WOULD LIKE TO 4930 03:01:32,600 --> 03:01:35,360 ENCOURAGE YOU TO ALSO LOOK AT 4931 03:01:35,360 --> 03:01:40,440 PEOPLE WHO ARE DOING WELL WITH 4932 03:01:40,440 --> 03:01:41,480 SCHIZOPHRENIA. PEOPLE DIAGNOSED 4933 03:01:41,480 --> 03:01:43,120 WITH SCHIZOPHRENIA AT YOUNGER 4934 03:01:43,120 --> 03:01:45,040 AGE BUT THEY ARE DOING WELL. MID 4935 03:01:45,040 --> 03:01:47,480 TO LATER LIFE BECAUSE I THINK 4936 03:01:47,480 --> 03:01:50,120 THAT THERE'S A LOT OF LESSONS WE 4937 03:01:50,120 --> 03:01:51,000 CAN LEARN WHAT FACTORS 4938 03:01:51,000 --> 03:01:53,840 CONTRIBUTED TO THIS SUCCESS. 4939 03:01:53,840 --> 03:01:55,960 IT'S ALMOST WHEN I SAY THIS, 4940 03:01:55,960 --> 03:01:57,760 PEOPLE ALMOST SAY WELL THIS JUST 4941 03:01:57,760 --> 03:02:00,160 DOESN'T HAPPEN, PEOPLE DON'T 4942 03:02:00,160 --> 03:02:01,760 RECOVER FROM THESE DISEASES, 4943 03:02:01,760 --> 03:02:04,280 WELL SOME PEOPLE DO. AND IN FACT 4944 03:02:04,280 --> 03:02:06,000 WE JUST RECENTLY COMPLETED A 4945 03:02:06,000 --> 03:02:08,680 STUDY WHERE WE INTERVIEWED OVER 4946 03:02:08,680 --> 03:02:09,800 800 PEOPLE, DIAGNOSED WITH 4947 03:02:09,800 --> 03:02:14,360 SERIOUS MENTAL ILLNESS, NOT ALL 4948 03:02:14,360 --> 03:02:16,280 WITH SCHIZOPHRENIA BUT MANY WITH 4949 03:02:16,280 --> 03:02:21,800 SCHIZOPHRENIA WHO ARE EMPLOYED 4950 03:02:21,800 --> 03:02:23,680 AND WORKING. NOT A DISABILITY 4951 03:02:23,680 --> 03:02:24,720 AND SUPPORTING THEMSELVES AND 4952 03:02:24,720 --> 03:02:26,000 DOING WELL. SO I THINK THIS IS 4953 03:02:26,000 --> 03:02:31,840 AN INTERESTING GROUP TO LOOK AT 4954 03:02:31,840 --> 03:02:32,800 AS WILL AS PEOPLE HAVING 4955 03:02:32,800 --> 03:02:33,400 CONTINUED ISSUES WITH THIS. 4956 03:02:33,400 --> 03:02:40,440 THANK YOU FOR TAKING ALL THIS. 4957 03:02:40,440 --> 03:02:41,720 >> SOFIA, SOMETHING ELSE TO ADD? 4958 03:02:41,720 --> 03:02:42,600 THANK YOU VERY MUCH FOR IF 4959 03:02:42,600 --> 03:02:44,640 DISCUSSION. AGAIN, LAURA AND 4960 03:02:44,640 --> 03:02:45,840 COLLEAGUES WILL TAKE THIS UNDER 4961 03:02:45,840 --> 03:02:47,160 CONSIDERATION AS THEY MOVE 4962 03:02:47,160 --> 03:02:49,400 FORWARD WITH THE INITIATIVE 4963 03:02:49,400 --> 03:02:51,200 WHICH I HEAR WITH VERY GOOD 4964 03:02:51,200 --> 03:02:54,320 AGREEMENT. NEXT UP WE HAVE A DUO 4965 03:02:54,320 --> 03:02:57,480 JENNIFER HUMENSKY, DIVISION OF 4966 03:02:57,480 --> 03:03:01,720 SERVICES INTERVENTION RESEARCH 4967 03:03:01,720 --> 03:03:05,360 AND LEO CUBILLOS, DEVELOPING 4968 03:03:05,360 --> 03:03:07,160 QUALITY MEASURES TO ADVANCE 4969 03:03:07,160 --> 03:03:08,280 MENTAL HEALTHCARE ACCESS AND 4970 03:03:08,280 --> 03:03:08,560 OUTCOMES. 4971 03:03:08,560 --> 03:03:10,160 >> THIS IS A JOINT CONCEPT LED 4972 03:03:10,160 --> 03:03:11,800 BY DIVISION OF SERVICES AND 4973 03:03:11,800 --> 03:03:14,480 INTERVENTION RESEARCH AND CENTER 4974 03:03:14,480 --> 03:03:18,240 FOR GLOBAL MEN DATA RESEARCH. 4975 03:03:18,240 --> 03:03:20,800 URGENT NEED EXISTS FOR VALIDATED 4976 03:03:20,800 --> 03:03:22,560 QUALITY MEASURES TO ACCESS 4977 03:03:22,560 --> 03:03:23,680 ANDANTE SENTIVE IMPROVEMENTS IN 4978 03:03:23,680 --> 03:03:25,320 ORDER TO ASSESS VALUE OF 4979 03:03:25,320 --> 03:03:25,960 SERVICES WE HAVE TO MEASURE 4980 03:03:25,960 --> 03:03:29,120 THEM. STANDARDIZE INSTRUMENTS 4981 03:03:29,120 --> 03:03:30,320 FOR ASSESSING CLINICAL STATS ARE 4982 03:03:30,320 --> 03:03:31,800 PLENTIFUL; THERE'S QUALITY 4983 03:03:31,800 --> 03:03:32,640 MEASURES ENDORSING USED AND 4984 03:03:32,640 --> 03:03:35,520 PRACTICE. IN ORDER TO 4985 03:03:35,520 --> 03:03:36,120 INCENTIVIZE HIGH QUALITY CARE 4986 03:03:36,120 --> 03:03:38,440 THROUGH IMPROVEMENT ACCESS AND 4987 03:03:38,440 --> 03:03:40,000 OUTCOMES EFFECTIVE QUALITY 4988 03:03:40,000 --> 03:03:41,240 MEASURES ASSESSING CONCEPTS ARE 4989 03:03:41,240 --> 03:03:42,280 NEEDED AND THESE SHOULD BE 4990 03:03:42,280 --> 03:03:44,240 ENDORSED BY RELEVANT GOVERNING 4991 03:03:44,240 --> 03:03:45,120 BODIES TO FA SIGNATURE AT A TIME 4992 03:03:45,120 --> 03:03:48,280 TAKE UP BY PAYERS. O FACILITATE. 4993 03:03:48,280 --> 03:03:49,800 TO DEFINE CONCEPTS QUALITY 4994 03:03:49,800 --> 03:03:51,760 MEASURES ASSESS THE RATE OF 4995 03:03:51,760 --> 03:03:52,720 TARGET OUTCOME ACROSS THE 4996 03:03:52,720 --> 03:03:54,880 POPULATION. AND AS ENDORSED 4997 03:03:54,880 --> 03:03:57,680 OUTCOMES FOCUS MEASURE IS AMONG 4998 03:03:57,680 --> 03:03:59,880 INDIVIDUALS ASSESS WITH 4999 03:03:59,880 --> 03:04:00,720 DEPRESSION, WHAT PERCENT REACH 5000 03:04:00,720 --> 03:04:02,600 CERTAIN LEVEL IMPROVEMENT BY SIX 5001 03:04:02,600 --> 03:04:04,920 OR 12 MONTHS. DOES DEPRESSION 5002 03:04:04,920 --> 03:04:06,000 SCORES CLINICAL MEASURE AND 5003 03:04:06,000 --> 03:04:07,800 CHANGE IN SYMPTOM LEVEL'S CROSS 5004 03:04:07,800 --> 03:04:09,120 POPULATION LEVEL AS THE OUTCOME 5005 03:04:09,120 --> 03:04:12,080 MEASURE. ACCESS FOCUS QUALITY 5006 03:04:12,080 --> 03:04:13,760 MEASURES ASSESS TIMELY USE OF 5007 03:04:13,760 --> 03:04:15,920 SERVICES OVERLAPPING 5008 03:04:15,920 --> 03:04:17,600 AFFORDABILITY AVAILABILITY AND 5009 03:04:17,600 --> 03:04:18,840 TIME THROUGHLINESS AND ENDORSED 5010 03:04:18,840 --> 03:04:21,040 ACCESS MEASURE IS PROPORTION OF 5011 03:04:21,040 --> 03:04:23,440 ADULTS WITH MAJOR DEPRESSIVE 5012 03:04:23,440 --> 03:04:24,640 EPISODES RECEIVING TREATMENT. 5013 03:04:24,640 --> 03:04:25,880 THESE ARE USED TO DEVELOP 5014 03:04:25,880 --> 03:04:27,040 DELIVER MONITOR AND IMPROVE 5015 03:04:27,040 --> 03:04:28,600 CARE. FOR EXAMPLE FACILITY AT A 5016 03:04:28,600 --> 03:04:30,080 TIME MEASUREMENT BASED CARE 5017 03:04:30,080 --> 03:04:31,880 EVALUATE EFFECTIVENESS OF 5018 03:04:31,880 --> 03:04:33,320 SERVICES, AND IMPLEMENT 5019 03:04:33,320 --> 03:04:35,240 CONTINUOUS QUALITY IMPROVEMENT 5020 03:04:35,240 --> 03:04:37,080 INITIATIVES AND TEST AND CAM 5021 03:04:37,080 --> 03:04:39,240 PAIR ALTERNATE MODELS SERVICE 5022 03:04:39,240 --> 03:04:40,800 DELIVERY AND PAYMENT OVAL WAIT 5023 03:04:40,800 --> 03:04:42,560 SHIFTING FROM DIVISIONAL FEES 5024 03:04:42,560 --> 03:04:44,040 FOR SERVICE TO VALUE BASED 5025 03:04:44,040 --> 03:04:46,000 PAYMENT MODELS. NEXT SLIDE 5026 03:04:46,000 --> 03:04:47,440 PLEASE. THIS CONCEPT AIMS TO 5027 03:04:47,440 --> 03:04:49,200 SUPPORT DEVELOPMENT TESTING 5028 03:04:49,200 --> 03:04:50,480 VALIDATION AND IMPLEMENTATION OF 5029 03:04:50,480 --> 03:04:53,160 MEASURES TO ADVANCE MENTAL 5030 03:04:53,160 --> 03:04:55,200 HEALTH CARE ACCESS OUTCOMES AND 5031 03:04:55,200 --> 03:04:56,040 QUALITY IN THE UNITED STATES 5032 03:04:56,040 --> 03:04:57,280 OTHER HIGH INCOME COUNTRIES AND 5033 03:04:57,280 --> 03:05:00,400 LOW AND MIDDLE INCOME CRIBS. 5034 03:05:00,400 --> 03:05:01,480 FACILITATION OF FINDINGS TO 5035 03:05:01,480 --> 03:05:04,080 PRACTICE THIS CONCEPT SEEKS TO 5036 03:05:04,080 --> 03:05:04,680 SUPPORT DEVELOPMENT AND 5037 03:05:04,680 --> 03:05:06,080 VALIDATION OF MEASURES AN DATA 5038 03:05:06,080 --> 03:05:07,880 COLLECTION REVIEWED ENDORSED BY 5039 03:05:07,880 --> 03:05:09,480 RELEVANT GOVERNING OR REGULATORY 5040 03:05:09,480 --> 03:05:11,040 BODIES. FOR EXAMPLE IN THE 5041 03:05:11,040 --> 03:05:12,120 UNITED STATES THIS COULD INCLUDE 5042 03:05:12,120 --> 03:05:13,080 THE NATIONAL QUALITY FORUM 5043 03:05:13,080 --> 03:05:15,000 FUNDED BY CONGRESS AND ENDORSED 5044 03:05:15,000 --> 03:05:16,720 BY OFFICE OF MANAGEMENT AND 5045 03:05:16,720 --> 03:05:17,960 BUDGET O TO SUPPORT ASSESSING 5046 03:05:17,960 --> 03:05:20,120 QUALITY MEASURES. OTHER 5047 03:05:20,120 --> 03:05:21,000 COUNTRIES INCLUDE ADMINISTRATIVE 5048 03:05:21,000 --> 03:05:22,280 HEALTH OR OTHER RELEVANT 5049 03:05:22,280 --> 03:05:27,680 GOVERNING BODIES. 5050 03:05:27,680 --> 03:05:29,840 CONSISTENT WITH STRATEGIC FOUR 5051 03:05:29,840 --> 03:05:31,840 OF NIH PLAN RESEARCH THIS IS 5052 03:05:31,840 --> 03:05:33,280 RESEARCH TO DO THE FOLLOWING 5053 03:05:33,280 --> 03:05:34,560 DEVELOPING TESTING MEASURES OF 5054 03:05:34,560 --> 03:05:36,880 ACCESS TO MENTAL HEALTHCARE AND 5055 03:05:36,880 --> 03:05:38,560 CONTINUITY OF CARE OR DEVELOPING 5056 03:05:38,560 --> 03:05:39,480 AND TESTING NEW MEASURES OF 5057 03:05:39,480 --> 03:05:40,720 MENTAL HEALTH QUALITY BASTED ON 5058 03:05:40,720 --> 03:05:44,520 EXISTING STANDARDIZED CLINICAL 5059 03:05:44,520 --> 03:05:47,000 MEASURES, IN EXAMPLE GIVEN 5060 03:05:47,000 --> 03:05:47,520 PREVIOUSLY USING TESTIMONY 5061 03:05:47,520 --> 03:05:48,480 CLINICAL MEASURE OF DEPRESSION 5062 03:05:48,480 --> 03:05:49,760 TO DEVELOP POPULATION BASED 5063 03:05:49,760 --> 03:05:52,040 OUTCOMELESS MEASURES. OR 5064 03:05:52,040 --> 03:05:53,080 DEVELOPING TESTING NEW MEASURES 5065 03:05:53,080 --> 03:05:55,240 WHICH ARE NOT BASED ON CURRENTLY 5066 03:05:55,240 --> 03:05:57,480 EXISTING CLINICAL MEASURES. OR 5067 03:05:57,480 --> 03:05:58,520 TO ADAPTS AND TEST EXISTING 5068 03:05:58,520 --> 03:06:00,680 GENERAL HEALTHCARE MEASURES THAT 5069 03:06:00,680 --> 03:06:02,240 COULD BE ADAPTED TO MENTAL 5070 03:06:02,240 --> 03:06:06,280 HEALTH SERVICES. FINALLY SHOULD 5071 03:06:06,280 --> 03:06:08,320 BE NOTED PROJECTS WILL BE 5072 03:06:08,320 --> 03:06:11,080 EXPECTED TO DEVELOP WITH INPUT 5073 03:06:11,080 --> 03:06:12,280 OF KEY STAKEHOLDERS. WITH THAT 5074 03:06:12,280 --> 03:06:13,520 WE WOULD WELCOME FEEDBACK FROM 5075 03:06:13,520 --> 03:06:15,280 COUNCIL. 5076 03:06:15,280 --> 03:06:17,320 >> THANK YOU VERY MUCH, LAURA. 5077 03:06:17,320 --> 03:06:21,720 WE HAVE DR.s MARJORIE BALDWIN. 5078 03:06:21,720 --> 03:06:22,680 WOULD YOU START OFF. 5079 03:06:22,680 --> 03:06:26,680 >> THANKS, JOSH. I'M VERY 5080 03:06:26,680 --> 03:06:28,280 ENTHUSIASTICALLY ENDORSE THIS 5081 03:06:28,280 --> 03:06:29,440 CONCEPT AND GLAD TO SEE NIMH 5082 03:06:29,440 --> 03:06:32,800 PUTTING IT FORWARD. RECENT 5083 03:06:32,800 --> 03:06:34,400 ARTICLE IN WORLD PSYCHIATRY 5084 03:06:34,400 --> 03:06:36,600 NOTED THAT THE OVERALL QUALITY 5085 03:06:36,600 --> 03:06:40,160 OF MENTAL HEALTHCARE GLOBALLY IS 5086 03:06:40,160 --> 03:06:41,480 POOR AND IMPROVEMENTS IN QUALITY 5087 03:06:41,480 --> 03:06:43,960 HAVE LAGGED BEHIND IMPROVEMENTS 5088 03:06:43,960 --> 03:06:45,400 IN QUALITY OF CARE FOR PHYSICAL 5089 03:06:45,400 --> 03:06:49,120 CONDITIONS. THE AUTHORS SAY THAT 5090 03:06:49,120 --> 03:06:51,360 EMPHASIZING THE IMPORTANCE OF 5091 03:06:51,360 --> 03:06:53,720 QUALITY MEASURES CANNOT IMPROVE 5092 03:06:53,720 --> 03:06:56,280 WHAT WE CANNOT MEASURE. SO I 5093 03:06:56,280 --> 03:06:59,200 WOULD SAY THAT THIS CONCEPT IS 5094 03:06:59,200 --> 03:07:04,040 ESSENTIAL TO DEVELOPING AND 5095 03:07:04,040 --> 03:07:08,400 IMPROVING -- YOU MUTED YOURSELF 5096 03:07:08,400 --> 03:07:10,960 AT THE VERY END THERE. 5097 03:07:10,960 --> 03:07:14,360 >> I ONLY BACK NOW. OKAY. I DO 5098 03:07:14,360 --> 03:07:18,280 HAVE A COUPLE OF SUGGESTIONS 5099 03:07:18,280 --> 03:07:19,600 BASICALLY ABOUT WHAT OUTCOMES 5100 03:07:19,600 --> 03:07:23,040 ARE GOING TO BE MEASURED. I 5101 03:07:23,040 --> 03:07:24,880 NOTICE THAT THE CONCEPT MENTIONS 5102 03:07:24,880 --> 03:07:26,720 CLINICAL STATUS AND CLINICAL 5103 03:07:26,720 --> 03:07:28,840 IMPROVEMENT AND I THINK CLINICAL 5104 03:07:28,840 --> 03:07:30,280 MEASURES ARE NECESSARY BUT ARE 5105 03:07:30,280 --> 03:07:31,400 NOT SUFFICIENT WHEN TALKING 5106 03:07:31,400 --> 03:07:34,160 ABOUT MENTAL HEALTH ISSUES. 5107 03:07:34,160 --> 03:07:36,280 GIVEN THE COMPLEXITY OF THE WAY 5108 03:07:36,280 --> 03:07:38,200 MENTAL ILLNESS AFFECTS PATIENT 5109 03:07:38,200 --> 03:07:41,360 WELL BEING I THINK THAT NEED TO 5110 03:07:41,360 --> 03:07:43,120 FOCUS ON BROAD RANGE OF OUTCOMES 5111 03:07:43,120 --> 03:07:44,840 MEASURES INCLUDING QUALITY OF 5112 03:07:44,840 --> 03:07:47,840 LIFE, MEANINGFUL RECOVERY 5113 03:07:47,840 --> 03:07:49,120 MEASURES, AND MEASURES OF 5114 03:07:49,120 --> 03:07:54,040 ENGAGEMENT WITH THE COMMUNITY 5115 03:07:54,040 --> 03:07:55,360 INCLUDING WORK AND FAMILY. I 5116 03:07:55,360 --> 03:07:57,720 NOTICE THAT JENNIFER MENTIONED 5117 03:07:57,720 --> 03:08:03,920 THEY WERE GOING TO REQUIRE THAT 5118 03:08:03,920 --> 03:08:05,800 APPLICANTS GET INPUT FROM KEY 5119 03:08:05,800 --> 03:08:08,160 STAKEHOLDERS, REALLY GLAD TO 5120 03:08:08,160 --> 03:08:10,800 HEAR THAT, ULTIMATELY THAT IS 5121 03:08:10,800 --> 03:08:14,920 WHAT COUNTS IS WE ARE PROVIDING 5122 03:08:14,920 --> 03:08:16,040 TREATMENT AS WELL AS INDIVIDUALS 5123 03:08:16,040 --> 03:08:19,040 WITH MENTAL ILLNESS TO OBTAIN 5124 03:08:19,040 --> 03:08:22,360 WHAT THEY FEEL IS RECOVERY BUT 5125 03:08:22,360 --> 03:08:26,280 -- AND OUTCOMES THEY FEEL ARE 5126 03:08:26,280 --> 03:08:28,520 IMPORTANT ALSO ARGUE IN FAVOR OF 5127 03:08:28,520 --> 03:08:31,120 THE FAMILY AND CAREGIVERS THAT 5128 03:08:31,120 --> 03:08:32,480 THEY ARE ALSO KEY STAKEHOLDERS 5129 03:08:32,480 --> 03:08:36,760 IN WHAT OUTCOMES ARE IMPORTANT. 5130 03:08:36,760 --> 03:08:38,560 COMMENT ON OUTCOMES OF ACCESS TO 5131 03:08:38,560 --> 03:08:40,880 CARE. WHEN I GOOGLED THESE I 5132 03:08:40,880 --> 03:08:43,480 FOUND WERE PRETTY MUCH GLOBAL 5133 03:08:43,480 --> 03:08:45,800 MEASURES OF PERCENT OF PEOPLE 5134 03:08:45,800 --> 03:08:47,480 THAT MEANS, PERCENT O P PEOPLE 5135 03:08:47,480 --> 03:08:48,840 NOT RECEIVING CAREER, PERCENT 5136 03:08:48,840 --> 03:08:51,680 NOT FOLLOWING UP, HE IS MEASURES 5137 03:08:51,680 --> 03:08:58,320 AREN'T INFORMATIVE HOW WE 5138 03:08:58,320 --> 03:08:59,920 IMPROVE I WOULD ARGUE GOING TO 5139 03:08:59,920 --> 03:09:05,320 BE IMPORTANT TO FOCUS ON 5140 03:09:05,320 --> 03:09:06,440 SPECIFIC SERVICES WHERE PEOPLE 5141 03:09:06,440 --> 03:09:09,760 ARE NOT BEING ABLE TO ACCESS, 5142 03:09:09,760 --> 03:09:13,240 FOR EXAMPLE SHORE TERM ACUTE 5143 03:09:13,240 --> 03:09:16,800 CARE IN PATIENT, AND JUST FROM 5144 03:09:16,800 --> 03:09:20,600 AN ECONOMIST ACCESSING GOOD OR 5145 03:09:20,600 --> 03:09:23,320 SERVICE THERE'S BASICALLY TWO 5146 03:09:23,320 --> 03:09:25,080 REASONS, ONE IS THEY NOT ABLE TO 5147 03:09:25,080 --> 03:09:27,400 PAY FOR THE SERVICE, AND THE 5148 03:09:27,400 --> 03:09:28,880 OTHER REASON IS POSSIBLE REASON 5149 03:09:28,880 --> 03:09:31,080 IS THERE IS INADEQUATE SUPPLY, 5150 03:09:31,080 --> 03:09:33,480 IN OTHER WORDS SHORTAGE. OF HOSE 5151 03:09:33,480 --> 03:09:35,920 SERVICES. THAT IS TWO DIFFERENT 5152 03:09:35,920 --> 03:09:37,600 ISSUES AND IT IS IMPORTANT IN 5153 03:09:37,600 --> 03:09:40,040 LOOKING AT OUTCOMES WITH RESPECT 5154 03:09:40,040 --> 03:09:41,400 TO ACCESS TO UNDERSTAND WHY ARE 5155 03:09:41,400 --> 03:09:44,760 PEOPLE UNABLE TO ACCESS IS IT 5156 03:09:44,760 --> 03:09:46,400 BECAUSE OF LACK OF INSURANCE, 5157 03:09:46,400 --> 03:09:48,360 LACK OF ABILITY TO PAY, LACK OF 5158 03:09:48,360 --> 03:09:51,200 WILLINGNESS TO PAY OR ARE THERE 5159 03:09:51,200 --> 03:09:54,200 SHORTAGES RELATED TO OUR 5160 03:09:54,200 --> 03:09:55,600 POLICIES REGARDING MENTAL HEALTH 5161 03:09:55,600 --> 03:09:59,360 SERVICES. THAT NEED TO BE 5162 03:09:59,360 --> 03:10:05,640 ADDRESSED. STRONGLY SUPPORT 5163 03:10:05,640 --> 03:10:08,880 THITHITHIS. 5164 03:10:08,880 --> 03:10:10,760 >> THANKS MARJORIE. ANYTHING TO 5165 03:10:10,760 --> 03:10:10,920 ADD? 5166 03:10:10,920 --> 03:10:12,640 >> I HUNDRED PERCENT AGREE 5167 03:10:12,640 --> 03:10:14,600 CONCUR I SHOULD SAY. WITH MY 5168 03:10:14,600 --> 03:10:16,800 COLLEAGUE, SHE COVERED A LOT OF 5169 03:10:16,800 --> 03:10:19,760 THE INITIAL POINTS I MAKE HER 5170 03:10:19,760 --> 03:10:22,360 LATTER COMMENTS SO I WILL KEEP 5171 03:10:22,360 --> 03:10:26,760 -- FOCUS MINE ON OTHER ISSUES SO 5172 03:10:26,760 --> 03:10:29,400 I DO SUPPORT BECAUSE IT IS 5173 03:10:29,400 --> 03:10:31,680 CLEARLY CONCEPTUALLY SOUND IN 5174 03:10:31,680 --> 03:10:35,920 TERMS OF WHAT IS INTENDED TO DO. 5175 03:10:35,920 --> 03:10:37,960 HOWEVER, THE REAL CHALLENGE IS 5176 03:10:37,960 --> 03:10:40,480 THAT IT IS REALLY BROAD. THE 5177 03:10:40,480 --> 03:10:42,880 BREADTH OF WHAT IT IS TRYING TO 5178 03:10:42,880 --> 03:10:43,600 ADDRESS PARTICULARLY AROUND 5179 03:10:43,600 --> 03:10:45,280 QUALITY MEASURES, IS THAT YOU 5180 03:10:45,280 --> 03:10:49,440 ARE LOOKING AT MULTIPLE TIERS 5181 03:10:49,440 --> 03:10:51,160 WITHIN SORT OF THE ECONOMIC 5182 03:10:51,160 --> 03:10:53,000 LEVELS OF THE DIFFERENT TYPES OF 5183 03:10:53,000 --> 03:10:54,880 COUNTRIES YOU ARE LOOKING AT SO 5184 03:10:54,880 --> 03:10:57,800 WHAT I'M SAYING IS THAT IT IS 5185 03:10:57,800 --> 03:11:01,200 GOING TO BE A TRANSLATIONAL 5186 03:11:01,200 --> 03:11:02,840 CHALLENGE WHEN YOU DEVELOP -- 5187 03:11:02,840 --> 03:11:06,240 DEVELOPING TOOLS IN THE UNITED 5188 03:11:06,240 --> 03:11:07,320 STATES, HOWEVER YOU ALSO ARE 5189 03:11:07,320 --> 03:11:10,080 GOING TO LOOK AT ACCRUAL AND 5190 03:11:10,080 --> 03:11:12,240 SEIZE ACROSS MIDDLE INCOME 5191 03:11:12,240 --> 03:11:15,560 COUNTRIES EQUIVALENCIES ACROSS 5192 03:11:15,560 --> 03:11:16,840 LOW INCOME COUNTRIES IF THAT IS 5193 03:11:16,840 --> 03:11:18,080 THE INTENT TO COME UP WITH THAT 5194 03:11:18,080 --> 03:11:20,120 BECAUSE YOU EMPHASIZE THE NEED 5195 03:11:20,120 --> 03:11:23,000 FOR STANDARDIZATION PARTICULARLY 5196 03:11:23,000 --> 03:11:24,320 AROUND QUALITY IN TERMS OF 5197 03:11:24,320 --> 03:11:27,480 SERVICE DELIVERY AND WORK. SO I 5198 03:11:27,480 --> 03:11:30,520 WOULD ADD THAT TO MY -- THE 5199 03:11:30,520 --> 03:11:32,840 COMMENTS WITH MY COLLEAGUE AS 5200 03:11:32,840 --> 03:11:38,960 EVEN A QUESTION ON THAT. ALSO AS 5201 03:11:38,960 --> 03:11:41,680 CONCEPT THAT WE HAVE COVERED 5202 03:11:41,680 --> 03:11:42,560 BEFORE, AT LEAST SINCE I HAVE 5203 03:11:42,560 --> 03:11:46,480 BEEN ON THE COUNCIL. AND IF IT 5204 03:11:46,480 --> 03:11:50,840 IS, THE MODIFICATIONS 5205 03:11:50,840 --> 03:11:53,160 THEMSELVES, STILL SHOULD BE 5206 03:11:53,160 --> 03:11:55,040 ADDRESSING THOSE TRANSLATIONAL 5207 03:11:55,040 --> 03:11:57,080 TYPE OF CHALLENGES PARTICULARLY 5208 03:11:57,080 --> 03:11:58,280 AROUND METHODOLOGY. SO 5209 03:11:58,280 --> 03:12:02,720 IDENTIFICATION OF WHAT IS TO BE 5210 03:12:02,720 --> 03:12:03,920 MEASURED PARTICULARLY WITHIN THE 5211 03:12:03,920 --> 03:12:10,560 CONTEXTUAL AREAS IS IMPORTANT. 5212 03:12:10,560 --> 03:12:11,360 BECAUSE BOTH OPERATIONAL 5213 03:12:11,360 --> 03:12:13,840 DEFINITION AS WELL AS TYPE OF 5214 03:12:13,840 --> 03:12:16,040 MEASUREMENT METHOD LOGICAL 5215 03:12:16,040 --> 03:12:16,600 APPROACH GATHERING THE 5216 03:12:16,600 --> 03:12:18,160 INFORMATION IS GOING TO BE REAL 5217 03:12:18,160 --> 03:12:19,880 CHALLENGE TO INVESTIGATORS WHO 5218 03:12:19,880 --> 03:12:21,880 ARE TRYING TO LOOK AT MEANS 5219 03:12:21,880 --> 03:12:23,360 WHICH THEY CAN STANDARDIZE THIS 5220 03:12:23,360 --> 03:12:27,480 AND ALSO LEVEL OF COST THAT IS 5221 03:12:27,480 --> 03:12:29,680 GOING TO REQUIRE TO BE INCLUSIVE 5222 03:12:29,680 --> 03:12:31,360 OF THE POPULATION ITSELF IS 5223 03:12:31,360 --> 03:12:33,160 GOING TO BE A CHALLENGE IN THE 5224 03:12:33,160 --> 03:12:38,080 LONG RUN. SO WHAT I'M SAYING IS 5225 03:12:38,080 --> 03:12:40,720 THAT NEEDS MORE WORK IN TERMS OF 5226 03:12:40,720 --> 03:12:41,800 JUST THINKING THROUGH METHOD 5227 03:12:41,800 --> 03:12:44,200 LOGICALLY HOW YOU ACTUALLY GET 5228 03:12:44,200 --> 03:12:46,520 AT THIS OR HOW YOU WOULD 5229 03:12:46,520 --> 03:12:49,200 INSTRUCT THOSE WHO ARE GOING TO 5230 03:12:49,200 --> 03:12:50,840 BE APPLYING THIS RESEARCH AND 5231 03:12:50,840 --> 03:12:52,680 THIS WORK PARTICULARLY THOSE WHO 5232 03:12:52,680 --> 03:12:55,640 ARE METHOD DOLL GISTS, THOSE WHO 5233 03:12:55,640 --> 03:12:57,800 ARE EXPERTS IN THINGS LIKE 5234 03:12:57,800 --> 03:13:00,120 QUALITY CONTROL AND QUALITY 5235 03:13:00,120 --> 03:13:01,400 ASSESSMENT AS WELL AS CALL OF 5236 03:13:01,400 --> 03:13:04,680 LIFE ISSUES THEY NEED TO HAVE A 5237 03:13:04,680 --> 03:13:07,880 LITTLE BIT MORE INSTRUCTION AND 5238 03:13:07,880 --> 03:13:09,240 CLARIFICATION OF WHAT IT IS THAT 5239 03:13:09,240 --> 03:13:11,000 YOU NEED SO IT LINES UP WITH 5240 03:13:11,000 --> 03:13:12,280 WHAT THEY ALREADY KNOW WHICH IS 5241 03:13:12,280 --> 03:13:13,200 BEST PRACTICES AS WELL AS WHAT 5242 03:13:13,200 --> 03:13:16,080 IS GOING TO BE DONE. SO I WOULD 5243 03:13:16,080 --> 03:13:20,280 SAY THAT. THEN MY LAST PART IS 5244 03:13:20,280 --> 03:13:21,640 ACCOUNTABILITY IN THIS WORK 5245 03:13:21,640 --> 03:13:25,080 PARTICULARLY WITH THE MIDDLE LOW 5246 03:13:25,080 --> 03:13:26,280 INCOME COUNTRIES PART IS THE 5247 03:13:26,280 --> 03:13:29,080 NEED TO ESTABLISH SOME KIND OF 5248 03:13:29,080 --> 03:13:32,320 CRITERIA FOR DEVELOPMENT AND 5249 03:13:32,320 --> 03:13:34,120 IMPLEMENTATION. THAT WILL ALLOW 5250 03:13:34,120 --> 03:13:35,960 YOU TO MAKE A JUDGMENT OF 5251 03:13:35,960 --> 03:13:41,160 WHETHER OR NOT WHAT IS BEING 5252 03:13:41,160 --> 03:13:42,560 APPLIED CONTEXTUALLY WHAT IT IS 5253 03:13:42,560 --> 03:13:45,560 YOU ARE LOOKING AT BASED ON A 5254 03:13:45,560 --> 03:13:47,320 WHOLE SLEW OF FACTORS IS GOING 5255 03:13:47,320 --> 03:13:49,560 TO BE REALLY IMPORTANT SO 5256 03:13:49,560 --> 03:13:52,440 ASSESSING THAT AND ASSESSING 5257 03:13:52,440 --> 03:13:55,400 EFFICACY OUTCOMES AND HAVING 5258 03:13:55,400 --> 03:13:56,520 SOME KIND OF PLAN CRITICALLY 5259 03:13:56,520 --> 03:13:58,240 BECAUSE YOU ARE DEVELOPING AND 5260 03:13:58,240 --> 03:14:00,280 LOOKING AT WAYS TO DEVELOP NEW 5261 03:14:00,280 --> 03:14:04,640 WAYS TO ASSESS AND NEW MEASURES 5262 03:14:04,640 --> 03:14:05,520 IS GOING FORWARD. THAT'S MY 5263 03:14:05,520 --> 03:14:07,320 COMMENT. THANK YOU. I APPRECIATE 5264 03:14:07,320 --> 03:14:08,120 BEING ASKED TO COMMENT ON THIS. 5265 03:14:08,120 --> 03:14:09,760 THANK YOU. 5266 03:14:09,760 --> 03:14:12,720 >> THANK YOU, JOSEPH. PATRICIA 5267 03:14:12,720 --> 03:14:15,080 DO YOU STILL HAVE YOUR HAND UP 5268 03:14:15,080 --> 03:14:15,760 FROM ABOVE OR COMMENT? 5269 03:14:15,760 --> 03:14:17,400 >> COMMENT ON THIS ONE TOO 5270 03:14:17,400 --> 03:14:17,680 PLEASE. 5271 03:14:17,680 --> 03:14:19,680 >> THANK YOU. 5272 03:14:19,680 --> 03:14:22,960 >> INTERESTINGLY, IN MANY OF THE 5273 03:14:22,960 --> 03:14:25,040 LOWER SOCIOECONOMICALLY 5274 03:14:25,040 --> 03:14:28,920 DEVELOPED COUNTRIES ACCESS TO 5275 03:14:28,920 --> 03:14:33,160 CELL PHONES IS EXTREMELY 5276 03:14:33,160 --> 03:14:34,880 WIDESPREAD. I THINK THAT THAT 5277 03:14:34,880 --> 03:14:36,160 MIGHT BE SOMETHING THAT WE MIGHT 5278 03:14:36,160 --> 03:14:39,120 WANT TO HIGHLIGHT SPECIFICALLY 5279 03:14:39,120 --> 03:14:44,600 AS FAR AS UTILIZING TOOLS TO 5280 03:14:44,600 --> 03:14:47,480 ASSESS NOT JUST HAVING PEOPLE 5281 03:14:47,480 --> 03:14:50,600 COMPLETE A CHECKLIST ON THEIR 5282 03:14:50,600 --> 03:14:53,240 PHONE BUT ALSO THINGS LIKE A 5283 03:14:53,240 --> 03:14:57,120 WATCH THAT EVEN IN AREAS WHERE 5284 03:14:57,120 --> 03:14:58,440 YOU ARE UNABLE TO BE SURE PEOPLE 5285 03:14:58,440 --> 03:15:00,800 HAVE ACCESS TO PHONE YOU CAN 5286 03:15:00,800 --> 03:15:03,040 GIVE A WATCH LIKE THIS TO 5287 03:15:03,040 --> 03:15:05,000 SOMEBODY AND IT WILL MONITOR 5288 03:15:05,000 --> 03:15:07,600 LEVEL OF ACTIVITY TIME OF SLEEP, 5289 03:15:07,600 --> 03:15:09,120 THEIR HEART RATE ALL KINDS OF 5290 03:15:09,120 --> 03:15:10,920 THINGS THAT ARE CLEARLY 5291 03:15:10,920 --> 03:15:13,400 ASSOCIATED WITH BIPOLAR 5292 03:15:13,400 --> 03:15:15,760 DISORDER. OBVIOUSLY THE PERSON 5293 03:15:15,760 --> 03:15:17,600 WITH -- WILL BE ROOTING FOR THEM 5294 03:15:17,600 --> 03:15:19,880 THE PERSON WITH DEPRESSION AND 5295 03:15:19,880 --> 03:15:23,680 SLEEP MIGHT BE ALSO AN ISSUE 5296 03:15:23,680 --> 03:15:26,200 THAT MIGHT BE ASSOCIATED WITH 5297 03:15:26,200 --> 03:15:31,640 DIAGNOSIS AS WELL SO SOME OF THE 5298 03:15:31,640 --> 03:15:32,720 PHYSIOLOGICAL COMPONENTS OF OUR 5299 03:15:32,720 --> 03:15:34,280 DISORDERS CAN BE EASILY MEASURED 5300 03:15:34,280 --> 03:15:36,160 IN A VERY PASSIVE WAY JUST 5301 03:15:36,160 --> 03:15:37,160 BYPASSING OUT ONE OF THESE 5302 03:15:37,160 --> 03:15:44,760 DEVICES. IN MY PAST LIFE AT THE 5303 03:15:44,760 --> 03:15:47,120 HOSPITAL WE HAD RESEARCH ON 5304 03:15:47,120 --> 03:15:49,720 SLEEP THAT PEOPLE REALLY DID 5305 03:15:49,720 --> 03:15:53,240 WELL WITH THE DEVICES AND THEY 5306 03:15:53,240 --> 03:15:55,880 WERE MUCH MORE EXPENSIVE THAN 5307 03:15:55,880 --> 03:15:58,000 THIS SO THIS MIGHT BE A SPECIFIC 5308 03:15:58,000 --> 03:16:01,360 AREA THAT WE MIGHT WANT TO CALL 5309 03:16:01,360 --> 03:16:02,800 OUT OUR REQUEST FOR 5310 03:16:02,800 --> 03:16:06,200 APPLICATIONS. 5311 03:16:06,200 --> 03:16:09,200 >> THANK YOU, PAT. ANY OTHER 5312 03:16:09,200 --> 03:16:11,280 COMMENTS OR QUESTIONS? ALL 5313 03:16:11,280 --> 03:16:13,840 RIGHT. I'M STILL HEARING 5314 03:16:13,840 --> 03:16:15,640 AGREEMENT WITH MOVING FORWARD 5315 03:16:15,640 --> 03:16:17,040 WITH THE INCORPORATION OF THE 5316 03:16:17,040 --> 03:16:19,120 COMMENTS, MOVE TO THE NEXT ONE. 5317 03:16:19,120 --> 03:16:23,720 WHICH IS ANDREA HORVATH MARQUES 5318 03:16:23,720 --> 03:16:24,960 CENTER FOR GLOBAL HEALTH 5319 03:16:24,960 --> 03:16:25,880 RESEARCH PRESENTING INITIATIVE 5320 03:16:25,880 --> 03:16:27,800 FOR RESEARCH SUICIDE PREVENTION 5321 03:16:27,800 --> 03:16:29,200 ACROSS THE LIFE SPAN IN LOW AND 5322 03:16:29,200 --> 03:16:32,360 MIDDLE INCOME COUNTRIES. AND 5323 03:16:32,360 --> 03:16:33,400 DR. MARQUES, PLEASE TAKE IT 5324 03:16:33,400 --> 03:16:35,600 AWAY. 5325 03:16:35,600 --> 03:16:37,720 >> THANK YOU, JOSH. I HAVE THE 5326 03:16:37,720 --> 03:16:39,160 HONOR TO PRESENT THIS CONCEPT 5327 03:16:39,160 --> 03:16:40,640 FROM THE CENTER FOR GLOBAL 5328 03:16:40,640 --> 03:16:42,400 MENTAL HEALTH DISAGGREGATION 5329 03:16:42,400 --> 03:16:43,840 ACROSS THE LIFE SPAN IN LOW AND 5330 03:16:43,840 --> 03:16:44,840 MIDDLE INCOME COUNTRIES BEFORE I 5331 03:16:44,840 --> 03:16:45,680 MOVE FORWARD I WOULD LIKE TO 5332 03:16:45,680 --> 03:16:48,000 THANK THE SUPPORT OF THE NIMH 5333 03:16:48,000 --> 03:16:48,800 SOCIETY IN DEVELOPING THIS 5334 03:16:48,800 --> 03:16:54,320 CONCEPTS. SUICIDE IS MAJOR 5335 03:16:54,320 --> 03:16:55,600 GLOBAL PUBLIC HEALTH PROBLEM. 5336 03:16:55,600 --> 03:16:57,720 OPT LEFT-HAND SIDE OF THIS SLIDE 5337 03:16:57,720 --> 03:16:59,360 SUICIDE IS AMONG LEADING 5338 03:16:59,360 --> 03:17:01,480 PREVENTABLE CAUSES OF DEATH 5339 03:17:01,480 --> 03:17:03,520 WORLDWIDE WITH MORE DEATH DUE TO 5340 03:17:03,520 --> 03:17:05,400 SUICIDE THAN MALARIA, HIV, AND 5341 03:17:05,400 --> 03:17:08,680 BREAST CANCER. OVER 700,000 5342 03:17:08,680 --> 03:17:11,880 PEOPLE DIE BY SUICIDE EACH YEAR 5343 03:17:11,880 --> 03:17:15,480 AND 77% OF THE GLOBAL SUICIDE 5344 03:17:15,480 --> 03:17:18,880 OCCURS IN LOW MIDDLE INCOME 5345 03:17:18,880 --> 03:17:19,560 COUNTRIES. THE GLOBAL ADJUSTED 5346 03:17:19,560 --> 03:17:24,840 SUICIDE RATE IS NOT HOWEVER RATE 5347 03:17:24,840 --> 03:17:26,920 VARY BUSINESS COUNTRIES AND 5348 03:17:26,920 --> 03:17:33,160 LOCATIONS SO THERE IS MUCH TO BE 5349 03:17:33,160 --> 03:17:43,000 DONE IN MARCH 2021, THE CENTER 5350 03:17:43,000 --> 03:17:44,120 HIGHLIGHTED NIMH INTEREST 5351 03:17:44,120 --> 03:17:44,840 IMPLEMENTING INTERVENTION 5352 03:17:44,840 --> 03:17:47,640 STRATEGIES TO REDUCE SUICIDE 5353 03:17:47,640 --> 03:17:51,120 RISK AND PROMOTE LOW AND MIDDLE 5354 03:17:51,120 --> 03:17:52,200 INCOME COUNTRIES, TODAY WE 5355 03:17:52,200 --> 03:17:54,640 PRESENT THE CONCEPT TO SUPPORT 5356 03:17:54,640 --> 03:17:56,160 RESEARCH TO IMPLEMENT AND 5357 03:17:56,160 --> 03:17:59,040 EVALUATE SCALABLE AND FINANCIAL 5358 03:17:59,040 --> 03:17:59,720 SUSTAINABLE PREVENTATIVE 5359 03:17:59,720 --> 03:18:01,720 INTERVENTIONS AND STRATEGIES TO 5360 03:18:01,720 --> 03:18:06,640 REDUCE SUICIDE RISK AND PROMOTE 5361 03:18:06,640 --> 03:18:08,720 -- RESEARCH APPLY MULTI-LEVEL 5362 03:18:08,720 --> 03:18:10,800 APPROACH EVALUATING UNIVERSAL 5363 03:18:10,800 --> 03:18:12,320 SELECTIVE AND INTERCOUNTRY 5364 03:18:12,320 --> 03:18:14,600 PREVENTION STRATEGIES AND 5365 03:18:14,600 --> 03:18:17,200 APPLYING WORLD HEALTH 5366 03:18:17,200 --> 03:18:18,160 ORGANIZATION LIFELINE APPROACH 5367 03:18:18,160 --> 03:18:19,800 TO GUIDE LIMITATION PROCESS AND 5368 03:18:19,800 --> 03:18:21,200 SUPPORT IDENTIFICATION OF 5369 03:18:21,200 --> 03:18:22,760 PREVENTATIVE STRATEGIES THAT ARE 5370 03:18:22,760 --> 03:18:23,680 RELEVANT AND APPROPRIATE FOR 5371 03:18:23,680 --> 03:18:28,200 EACH SETTING. RESEARCH THAT 5372 03:18:28,200 --> 03:18:30,280 APPLY BASED A APPROACH WHICH 5373 03:18:30,280 --> 03:18:31,920 FOCUSES NOT ONLY ON MENTAL 5374 03:18:31,920 --> 03:18:32,640 HEALTH CONCERNS WHICH IS 5375 03:18:32,640 --> 03:18:34,600 IMPORTANT BUT ALSO FOCUS ON THE 5376 03:18:34,600 --> 03:18:37,160 SPECIAL DETERMINANTS OF HEALTH 5377 03:18:37,160 --> 03:18:41,760 SUCH AS DOES CRIMINATION AND 5378 03:18:41,760 --> 03:18:44,200 POOR ACCESS TO CARE. WE ALSO 5379 03:18:44,200 --> 03:18:46,080 UNDERSTAND THE COLLABORATION 5380 03:18:46,080 --> 03:18:47,160 WITH GOVERNMENT SECTORS 5381 03:18:47,160 --> 03:18:48,760 INTERNATIONAL DEVELOPING 5382 03:18:48,760 --> 03:18:51,040 AGENCIES AND HEALTH AGENCIES AND 5383 03:18:51,040 --> 03:18:52,840 OTHERS AT NOT ONLY IMPORTANT BUT 5384 03:18:52,840 --> 03:18:55,440 NECESSARY TO ABLE TO ADDRESS 5385 03:18:55,440 --> 03:18:56,800 THIS MAJOR HEALTH ISSUE. HERE 5386 03:18:56,800 --> 03:19:00,720 THE NEXT SLIDE PLEASE, EXAMPLES 5387 03:19:00,720 --> 03:19:02,640 OF RESEARCH WE ANTICIPATE 5388 03:19:02,640 --> 03:19:04,320 SUPPORT. RESEARCH THAT WE 5389 03:19:04,320 --> 03:19:06,760 IDENTIFY IN PROTECTIVE RISK 5390 03:19:06,760 --> 03:19:07,720 FACTORS THAT MIGHT SERVICE 5391 03:19:07,720 --> 03:19:09,000 TARGETS FOR PREVENTIVE 5392 03:19:09,000 --> 03:19:11,440 INTERVENTION SUCH AS MENTAL 5393 03:19:11,440 --> 03:19:13,160 ILLNESS, SOCIAL DETERMINANTS OF 5394 03:19:13,160 --> 03:19:14,600 HEALTH TO TEST AND IMPLEMENT 5395 03:19:14,600 --> 03:19:17,800 UNIVERSAL PREVENTIVE STRATEGY, 5396 03:19:17,800 --> 03:19:19,480 RESTRICTION MEANS AND TEST 5397 03:19:19,480 --> 03:19:21,440 IMPLEMENTED SELECTIVE PREVENTIVE 5398 03:19:21,440 --> 03:19:22,800 STRATEGIES TO INTEGRATE SUICIDE 5399 03:19:22,800 --> 03:19:26,600 SCREENING, ASSESSMENT AND 5400 03:19:26,600 --> 03:19:28,680 INTERVENTION HEALTH SYSTEMS AND 5401 03:19:28,680 --> 03:19:30,560 LEVELS. FINALLY WE ALSO LOOK 5402 03:19:30,560 --> 03:19:32,000 INTO SUPPORT RESEARCH THAT 5403 03:19:32,000 --> 03:19:35,160 IMPLEMENT AND EVALUATE 5404 03:19:35,160 --> 03:19:35,680 SURVEILLANCE SYSTEMS AND 5405 03:19:35,680 --> 03:19:37,640 IMPLEMENT STRATEGIES FOCUS ON 5406 03:19:37,640 --> 03:19:39,080 FINANCIAL MODELS OR POLICIES AND 5407 03:19:39,080 --> 03:19:41,000 REGULATIONS THAT COULD INFLUENCE 5408 03:19:41,000 --> 03:19:44,360 THE SUCCESS OF SCALING UP AND 5409 03:19:44,360 --> 03:19:45,280 SUSTAINING PREVENTIVE 5410 03:19:45,280 --> 03:19:47,720 STRATEGIES. THANK YOU FOR YOUR 5411 03:19:47,720 --> 03:19:50,640 ATTENTION. HAPP HAPPY TO TAKE 5412 03:19:50,640 --> 03:19:52,000 QUESTIONS AND LOOK FORWARD TO 5413 03:19:52,000 --> 03:19:53,000 YOUR FEEDBACK. 5414 03:19:53,000 --> 03:19:55,280 >> THANK YOU, ANDREA. WE HAVE 5415 03:19:55,280 --> 03:19:57,040 ASKED DR.S MATT KNOCK AND 5416 03:19:57,040 --> 03:20:01,160 MARGUERITA LIGHTFOOT TO COMMENT. 5417 03:20:01,160 --> 03:20:03,720 MATT LEAD OFF? HAPPY TO. THANKS 5418 03:20:03,720 --> 03:20:05,160 FOR THE OPPORTUNITY TO COMMENT. 5419 03:20:05,160 --> 03:20:07,320 I STRONGLY SUPPORT THIS CONCEPT 5420 03:20:07,320 --> 03:20:09,480 CLEARANCE. IT FOCUSES ON AS 5421 03:20:09,480 --> 03:20:11,120 OUTLINED REALLY IMPORTANT TOPIC 5422 03:20:11,120 --> 03:20:11,960 SUICIDE CONTINUES TO BE A 5423 03:20:11,960 --> 03:20:13,960 LEADING CAUSE OF DEATH IN THE 5424 03:20:13,960 --> 03:20:15,920 U.S. WORLDWIDE AS NOTED THREE 5425 03:20:15,920 --> 03:20:16,920 QUARTERS, MORE THAN THREE 5426 03:20:16,920 --> 03:20:18,000 QUARTERS OF SUICIDE HAPPEN IN 5427 03:20:18,000 --> 03:20:21,160 LOW AND MIDDLE INCOME COUNTRIES 5428 03:20:21,160 --> 03:20:23,960 WE HAVE DATA FROM THE WORLD 5429 03:20:23,960 --> 03:20:24,640 HEALTH ORGANIZATION HEALTH 5430 03:20:24,640 --> 03:20:26,200 SURVEY INITIATIVE FUNDED IN 5431 03:20:26,200 --> 03:20:28,280 LARGE PART BY NIMH LOOK AT 5432 03:20:28,280 --> 03:20:29,600 SUICIDE IN TWO DOZEN COUNTRIES 5433 03:20:29,600 --> 03:20:31,040 AROUND THE WORLD AND FOUND 5434 03:20:31,040 --> 03:20:32,640 SIMILAR RISK FACTORS IN LOW AND 5435 03:20:32,640 --> 03:20:34,520 MIDDLE INCOME COUNTRIES, TO 5436 03:20:34,520 --> 03:20:36,360 THOSE SEEN IN HIGH INCOME 5437 03:20:36,360 --> 03:20:37,200 COUNTRIES THOUGH THERE WERE 5438 03:20:37,200 --> 03:20:38,040 IMPORTANT DIFFERENCES, THAT 5439 03:20:38,040 --> 03:20:39,400 BEING SAID THERE A LOT WE DON'T 5440 03:20:39,400 --> 03:20:41,680 KNOW AS HIGHLIGHTED SO THIS 5441 03:20:41,680 --> 03:20:43,360 CONCEPT CLEARANCE FOCUSES ON 5442 03:20:43,360 --> 03:20:45,840 THIS PROBLEM AND IMPORTANT GAPS 5443 03:20:45,840 --> 03:20:48,280 ONE FEW QUICK THINGS TO NOTE IF 5444 03:20:48,280 --> 03:20:50,360 THIS MOVE FORWARD REQUEST 5445 03:20:50,360 --> 03:20:52,160 PROPOSAL ENCOURAGE DEVELOPERS TO 5446 03:20:52,160 --> 03:20:53,800 BE EXPLICIT WHAT KINDS OF 5447 03:20:53,800 --> 03:20:55,280 PROJECTS SHOULD BE THE FOCUS. I 5448 03:20:55,280 --> 03:20:57,080 THOUGHT AS WRITTEN IT IS REALLY 5449 03:20:57,080 --> 03:20:59,000 BROAD AND COVERS LOOKING AGENT 5450 03:20:59,000 --> 03:20:59,920 THE SLIDE EVERYTHING FROM 5451 03:20:59,920 --> 03:21:01,800 IDENTIFYING PEOPLE LOOK AT RISK 5452 03:21:01,800 --> 03:21:03,040 FACTORS PROTECTIVE FACTORS 5453 03:21:03,040 --> 03:21:06,160 WORKING ACROSS LEVELS, UNIVERSAL 5454 03:21:06,160 --> 03:21:07,240 PREVENTION, FOCUS TREATMENTS 5455 03:21:07,240 --> 03:21:09,200 THERE IS A LOT IN THERE, WHICH 5456 03:21:09,200 --> 03:21:10,720 MAYBE IS FINE BUT THERE IS A LOT 5457 03:21:10,720 --> 03:21:13,160 THAT NEEDS TO BE IMPROVED IN 5458 03:21:13,160 --> 03:21:13,760 SUICIDE PREDICTION AND 5459 03:21:13,760 --> 03:21:15,760 PREVENTION LITERATURE, A LOT OF 5460 03:21:15,760 --> 03:21:17,360 THIS STUDIES PREVENTION STUDIES 5461 03:21:17,360 --> 03:21:18,720 FOR INSTANCE THAT ARE DONE IN 5462 03:21:18,720 --> 03:21:20,320 THE U.S. ARE SMALL AND 5463 03:21:20,320 --> 03:21:21,680 UNDERPOWERED. THERE IS NOT AS 5464 03:21:21,680 --> 03:21:24,240 MUCH FOCUS AS THERE NEEDS TO BE 5465 03:21:24,240 --> 03:21:26,200 ON ACTUAL PREVENTION OF SUICIDE 5466 03:21:26,200 --> 03:21:28,760 BEHAVIORS AND DEATH. AND FOCUS 5467 03:21:28,760 --> 03:21:30,640 ON LOW MIDDLE FIRST QUARTER 5468 03:21:30,640 --> 03:21:32,200 COUNTRY THERE'S DANGER FOR THOSE 5469 03:21:32,200 --> 03:21:33,720 DESIGN TO BE REPLICATED. WE 5470 03:21:33,720 --> 03:21:37,200 WANT TO FOCUS ON SCALABLE 5471 03:21:37,200 --> 03:21:37,680 EFFICIENT INTERVENTIONS 5472 03:21:37,680 --> 03:21:39,040 PREVENTION PROGRAMS, THAT HAVE 5473 03:21:39,040 --> 03:21:41,200 REAL SHOT AT DECREASING RISK OF 5474 03:21:41,200 --> 03:21:42,640 SUICIDAL BEHAVIOR AND DEPLOYED 5475 03:21:42,640 --> 03:21:44,000 IN RANGE OF DIFFERENT OUTCOMES. 5476 03:21:44,000 --> 03:21:47,400 SO THIS IS A REALLY GREAT FOCUS 5477 03:21:47,400 --> 03:21:48,480 THAT TO MY VIEW SHOULD BE HAVE A 5478 03:21:48,480 --> 03:21:50,920 LITTLE FINER POINT PUT ON IT TO 5479 03:21:50,920 --> 03:21:51,760 MAKE HUER STUDIES DONE ARE 5480 03:21:51,760 --> 03:21:52,720 METHOD LOGICALLY RIGOROUS AND 5481 03:21:52,720 --> 03:21:54,040 FOCUS ON OUTCOMES WE WANT TO 5482 03:21:54,040 --> 03:21:56,640 PREVENT. AND I THINK THIS COULD 5483 03:21:56,640 --> 03:21:58,480 BE A GOOD MECHANISM WHAT WORKS 5484 03:21:58,480 --> 03:21:59,720 GENERALLY, A LOT CAN BE LEARNED 5485 03:21:59,720 --> 03:22:02,960 IN LOWER AND MIDDLE INCOME 5486 03:22:02,960 --> 03:22:04,880 COUNTRIES THAT CAN BE USED IN 5487 03:22:04,880 --> 03:22:05,720 HIGH INCOME COUNTRIES WHERE 5488 03:22:05,720 --> 03:22:07,000 RESOURCES ARE LESS AVAILABLE SO 5489 03:22:07,000 --> 03:22:08,160 GREAT CHANCE TO LEARN A GREAT 5490 03:22:08,160 --> 03:22:09,200 DEAL. I SUPPORT THIS. THANKS 5491 03:22:09,200 --> 03:22:10,440 AGAIN. 5492 03:22:10,440 --> 03:22:13,200 >> THANK YOU, MATTHEW. 5493 03:22:13,200 --> 03:22:16,560 MARGUERITA. 5494 03:22:16,560 --> 03:22:21,200 >> I ALSO STRONGLY SUPPORT THIS 5495 03:22:21,200 --> 03:22:24,320 AND THE IDEA THAT THE RECORDED 5496 03:22:24,320 --> 03:22:25,720 SUICIDE THAT OCCUR IN THE WORLD 5497 03:22:25,720 --> 03:22:29,320 ARE AMONG LOW AND MIDDLE FIRST 5498 03:22:29,320 --> 03:22:32,200 QUARTER COUNTRIES IS STAGGERING 5499 03:22:32,200 --> 03:22:33,320 AND -- INCOME COUNTRIES IS 5500 03:22:33,320 --> 03:22:35,160 STAGGERING AND UNDERESTIMATE OF 5501 03:22:35,160 --> 03:22:37,000 SUICIDE RISK AND SUICIDE IS 5502 03:22:37,000 --> 03:22:39,040 HAPPENING. I REALLY ALSO JUST TO 5503 03:22:39,040 --> 03:22:40,400 UNDERSCORE WHAT WAS SAID BEFORE, 5504 03:22:40,400 --> 03:22:42,280 FOCUS ON IMPLEMENTATION SCIENCE 5505 03:22:42,280 --> 03:22:43,520 AND SCALABILITY IS GOING TO BE 5506 03:22:43,520 --> 03:22:46,840 CRITICAL. SO THAT WE ARE NOT 5507 03:22:46,840 --> 03:22:47,440 REPLICATING SOME OF THE 5508 03:22:47,440 --> 03:22:51,440 LIMITATIONS THAT WE HAVE SEEN IN 5509 03:22:51,440 --> 03:22:54,000 STUDIES THAT HAPPENED IN THE US 5510 03:22:54,000 --> 03:22:57,160 AND OTHER WESTERN COUNTRIES. ON 5511 03:22:57,160 --> 03:22:58,720 THAT NOTE I WOULD ALSO WHILE I 5512 03:22:58,720 --> 03:22:59,920 AGREE THERE IS A NEED TO 5513 03:22:59,920 --> 03:23:02,560 IMPLEMENT CULTURALLY ADAPTIVE 5514 03:23:02,560 --> 03:23:05,520 INTERVENTIONS, I WANT TO ENSURE 5515 03:23:05,520 --> 03:23:08,960 THAT WE ARE ALSO VALUE PROMOTE 5516 03:23:08,960 --> 03:23:10,120 IN COUNTRY KNOWLEDGE AND 5517 03:23:10,120 --> 03:23:13,600 EXPERTISE AND CAREFUL NOT TO 5518 03:23:13,600 --> 03:23:16,840 TAKE A COLONIAL APPROACH WITH 5519 03:23:16,840 --> 03:23:17,480 WESTERN KNOWLEDGE DICTATING WHAT 5520 03:23:17,480 --> 03:23:19,520 WE THINK WORKS AND WE ARE TRYING 5521 03:23:19,520 --> 03:23:21,200 TO REPLICATE THOSE THINGS AND 5522 03:23:21,200 --> 03:23:23,000 LMIC SO WE WANT TO MAKE SURE WE 5523 03:23:23,000 --> 03:23:27,040 HAVE ROOM AND ENCOURAGE 5524 03:23:27,040 --> 03:23:28,240 PARTNERSHIPS FOR THOSE AND 5525 03:23:28,240 --> 03:23:29,200 LMICs ABOUT THE MODEL 5526 03:23:29,200 --> 03:23:31,640 STRATEGIES AND INTERVENTIONS 5527 03:23:31,640 --> 03:23:34,520 THAT WOULD WORK WORK IN THOSE 5528 03:23:34,520 --> 03:23:36,720 PARTICULAR SETTINGS. I ALSO 5529 03:23:36,720 --> 03:23:39,760 REALLY APPRECIATE THE FACT THAT 5530 03:23:39,760 --> 03:23:44,000 THERE IS AN APPRECIATION IN THIS 5531 03:23:44,000 --> 03:23:49,280 CONCEPT THAT TREATMENT OR 5532 03:23:49,280 --> 03:23:50,480 PREVENTION OF SUICIDE INVOLVES A 5533 03:23:50,480 --> 03:23:53,120 WIDER RANGE OF APPROACHES BEYOND 5534 03:23:53,120 --> 03:23:54,680 JUST LOOKING AT PSYCHIATRIC 5535 03:23:54,680 --> 03:23:56,480 ILLNESS AND SO REALLY MAKING 5536 03:23:56,480 --> 03:23:58,800 EFFORTS TO INCORPORATE A WIDER 5537 03:23:58,800 --> 03:24:02,960 RANGE OF ACTIVITIES, SUCH AS 5538 03:24:02,960 --> 03:24:05,160 REDUCTION OF ACCESS TO 5539 03:24:05,160 --> 03:24:06,040 PESTICIDES, THINGS LIKE SOCIAL 5540 03:24:06,040 --> 03:24:07,360 DETERMINANTS OF HEALTH POVERTY, 5541 03:24:07,360 --> 03:24:09,160 ALSO INCLUDE THINGS LIKE 5542 03:24:09,160 --> 03:24:10,760 DOMESTIC VIOLENCE AND ALCOHOL 5543 03:24:10,760 --> 03:24:11,680 MISUSE AND ABUSE AS PART OF 5544 03:24:11,680 --> 03:24:17,200 THAT. GIVEN SUICIDE IS 5545 03:24:17,200 --> 03:24:20,920 PARTICULARLY HIGH AMONG 5546 03:24:20,920 --> 03:24:23,080 ADOLESCENTS THAN ADULTS, I WOULD 5547 03:24:23,080 --> 03:24:24,840 ENCOURAGE INCLUSION OF 5548 03:24:24,840 --> 03:24:26,240 DEVELOPMENTALLY APPROPRIATE 5549 03:24:26,240 --> 03:24:27,000 APPROACHES. FOR SUICIDE 5550 03:24:27,000 --> 03:24:30,000 PREVENTION. DOING THAT WITH 5551 03:24:30,000 --> 03:24:33,200 YOUNG PEOPLE IS GOING TO BE 5552 03:24:33,200 --> 03:24:37,040 REALLY IMPORTANT AND SPECIFIC. 5553 03:24:37,040 --> 03:24:39,640 MANY COUNTRIES SUICIDE BEHAVIORS 5554 03:24:39,640 --> 03:24:41,720 ALSO CRIMINALIZED SO WE HAVE TO 5555 03:24:41,720 --> 03:24:45,360 THINK ABOUT HOW WE -- WHAT IT 5556 03:24:45,360 --> 03:24:46,400 LOOKS LIKE WHAT THE CONTEXT LOOK 5557 03:24:46,400 --> 03:24:48,840 LIKE WHEN TRYING TO DO 5558 03:24:48,840 --> 03:24:51,080 PREVENTION SUICIDE WHEN IN MANY 5559 03:24:51,080 --> 03:24:53,200 COUNTRIES SUICIDAL BEHAVIOR IS 5560 03:24:53,200 --> 03:24:55,160 ILLEGAL. I ALSO APPRECIATE VERY 5561 03:24:55,160 --> 03:24:57,680 MUCH THE INCLUSION OF STIGMA AND 5562 03:24:57,680 --> 03:24:59,720 DISCRIMINATION NOT ONLY FOR 5563 03:24:59,720 --> 03:25:00,680 SUICIDE PREVENTION, BUT FOR 5564 03:25:00,680 --> 03:25:04,520 MENTAL HEALTH PROBLEMS. IN 5565 03:25:04,520 --> 03:25:05,440 GENERAL. SO INCORPORATING THAT 5566 03:25:05,440 --> 03:25:07,920 AND HAVING THAT AT THE FOREFRONT 5567 03:25:07,920 --> 03:25:09,640 IS GOING TO BE REALLY IMPORTANT 5568 03:25:09,640 --> 03:25:11,520 I ALSO VERY MUCH AGREE THAT THIS 5569 03:25:11,520 --> 03:25:14,720 WAS REALLY BROAD AND SO IT WAS 5570 03:25:14,720 --> 03:25:16,560 REALLY HARD TO -- GIVEN ALL THE 5571 03:25:16,560 --> 03:25:18,360 THINGS WE HAVE TALKED ABOUT 5572 03:25:18,360 --> 03:25:26,440 HAVING A LITTLE BIT MORE FINER 5573 03:25:26,440 --> 03:25:28,320 POINT WOULD BE HELPFUL IN TERMS 5574 03:25:28,320 --> 03:25:29,400 OF BUILDING THE SCIENCE FOR 5575 03:25:29,400 --> 03:25:32,160 THIS. VERY, VERY SUPPORTIVE AND 5576 03:25:32,160 --> 03:25:34,480 EXCITING ABOUT THIS. THANK YOU. 5577 03:25:34,480 --> 03:25:38,520 >> THANK YOU VERY MUCH. I'LL 5578 03:25:38,520 --> 03:25:40,120 NOTE MATT'S COMMENT IN THE CHAT 5579 03:25:40,120 --> 03:25:41,680 BOX READ FOR THE RECORD I WANT 5580 03:25:41,680 --> 03:25:44,120 TO SECOND DR. LIGHTFOOT'S 5581 03:25:44,120 --> 03:25:46,280 SUGGESTION DON'T JUST TRY TO 5582 03:25:46,280 --> 03:25:47,600 IMPLEMENT WESTERN PROGRAMS WE 5583 03:25:47,600 --> 03:25:49,040 HAVE STRONG INTERVENTION 5584 03:25:49,040 --> 03:25:50,120 PROGRAMS AND SO WOULD BENEFIT 5585 03:25:50,120 --> 03:25:51,600 FROM CONSIDERING APPROACHES 5586 03:25:51,600 --> 03:25:53,160 PROPOSED IN OTHER COUNTRIES AND 5587 03:25:53,160 --> 03:25:55,920 NOT YET TESTED. THERE OTHER 5588 03:25:55,920 --> 03:25:56,760 COMMENTS FROM MEMBERS OF THE 5589 03:25:56,760 --> 03:26:01,920 COUNCIL? SEEING NONE, ANDREA, 5590 03:26:01,920 --> 03:26:03,120 YOU HAVE YOUR CHARGE, DEVELOP A 5591 03:26:03,120 --> 03:26:07,040 LITTLE BIT STRONGER OF A FOCUS 5592 03:26:07,040 --> 03:26:08,600 AND THERE WAS SUGGESTIONS MAYBE 5593 03:26:08,600 --> 03:26:12,880 SPECIFIC FOCI. AND REALLY 5594 03:26:12,880 --> 03:26:14,000 APPRECIATE THE COMMENTS FROM 5595 03:26:14,000 --> 03:26:17,720 MATTHEW AND MARGUERITA. FINAL 5596 03:26:17,720 --> 03:26:19,920 CONCEPT CLEARANCE, YES GOING TO 5597 03:26:19,920 --> 03:26:23,440 GO PAST THE 4:30 HOUR, SHOULD 5598 03:26:23,440 --> 03:26:24,960 FINISH BEFORE 5 BUT THOSE WHO 5599 03:26:24,960 --> 03:26:27,200 NEED TO LEAVE PLEASE DO. WE 5600 03:26:27,200 --> 03:26:28,360 DON'T, TRACY, TAKE A VOTE ON 5601 03:26:28,360 --> 03:26:29,680 THESE CONCEPT CLEARANCES SO WE 5602 03:26:29,680 --> 03:26:35,600 DON'T NEED A QUORUM. FINAL 5603 03:26:35,600 --> 03:26:37,560 PRESENTATION IS WHICH GREGORY 5604 03:26:37,560 --> 03:26:38,440 GREENWOOD DIVISION OF AIDS 5605 03:26:38,440 --> 03:26:40,080 RESEARCH, HE WILL PRESENT ON 5606 03:26:40,080 --> 03:26:41,320 INNOVATIONS IN HIV PREVENTION 5607 03:26:41,320 --> 03:26:44,160 TESTING ADHERENCE AND RETENTION 5608 03:26:44,160 --> 03:26:46,360 TO OPTIMIZE HIV PREVENTION AND 5609 03:26:46,360 --> 03:26:51,000 CARE CONTINUUM OUTCOMES. 5610 03:26:51,000 --> 03:26:53,960 >> GREA GREAT. THANK YOU SO MUCI 5611 03:26:53,960 --> 03:26:56,400 WANT LIKE TO THANK MY COLLEAGUES 5612 03:26:56,400 --> 03:26:59,560 SUSANNA ALISON AND SUSIE POLLARD 5613 03:26:59,560 --> 03:27:01,040 IN HELPING PREPARING THIS 5614 03:27:01,040 --> 03:27:04,160 CONCEPT. SO THE GOAL OF THIS 5615 03:27:04,160 --> 03:27:05,760 CONCEPT IS TO ENCOURAGE YOU KNOW 5616 03:27:05,760 --> 03:27:07,720 INVESTIGATIVE BEHAVIORAL AND 5617 03:27:07,720 --> 03:27:09,120 SOCIAL SCIENCE RESEARCH TO 5618 03:27:09,120 --> 03:27:11,120 OPTIMIZE HIV PREVENTION AND 5619 03:27:11,120 --> 03:27:12,480 CARE, WHICH IS ALIGNED WITH THE 5620 03:27:12,480 --> 03:27:14,920 NIH OFFICE OF AIDS RESEARCH AND 5621 03:27:14,920 --> 03:27:17,200 NIMH DIVISION OF AIDS RESEARCH 5622 03:27:17,200 --> 03:27:19,720 PRIORITIES. APPLICATIONS 5623 03:27:19,720 --> 03:27:21,520 ENCOURAGED BY THIS INITIATIVE 5624 03:27:21,520 --> 03:27:23,720 COULD INCLUDE FORMATIVE BASIC 5625 03:27:23,720 --> 03:27:26,000 BEHAVIORAL AND SOCIAL SCIENCE 5626 03:27:26,000 --> 03:27:27,000 RESEARCH, INITIAL DEVELOPMENT 5627 03:27:27,000 --> 03:27:29,720 AND PILOT TESTING, OR 5628 03:27:29,720 --> 03:27:31,640 INTERVENTION EFFICACY AND 5629 03:27:31,640 --> 03:27:33,160 EFFECTIVENESS TRIALS. OR 5630 03:27:33,160 --> 03:27:36,200 IMPLEMENTATION SCIENCE RESEARCH 5631 03:27:36,200 --> 03:27:38,600 THE NIH STRATEGIC PLAN FOR HIV 5632 03:27:38,600 --> 03:27:40,560 AND HIV RELATED RESEARCH FOR 5633 03:27:40,560 --> 03:27:43,720 FISCAL YEARS 21 TO 25 OUTLINES A 5634 03:27:43,720 --> 03:27:45,240 ROBUST RESEARCH AGENDA WITH 5635 03:27:45,240 --> 03:27:46,240 HIGHLIGHTS OF KEY PRIORITY 5636 03:27:46,240 --> 03:27:51,920 AREAS. SO THERE'S BEEN GROUND 5637 03:27:51,920 --> 03:27:54,120 BREAKING ADVANCES IN BIOMEDICAL 5638 03:27:54,120 --> 03:27:56,840 HIV RESEARCH THAT HAVE LED TO 5639 03:27:56,840 --> 03:27:59,720 EFFECTIVE TREATMENTS SUCH AS 5640 03:27:59,720 --> 03:28:01,160 ANTI-RETROVIRAL THERAPY, AN 5641 03:28:01,160 --> 03:28:04,360 EFFECTIVE PREVENTION SUCH AS 5642 03:28:04,360 --> 03:28:05,000 PRE-EXPOSURE PROPHYLAXIS THAT 5643 03:28:05,000 --> 03:28:07,840 ALLOWS PEOPLE LIVING WITH HIV TO 5644 03:28:07,840 --> 03:28:09,280 LIVE LONGER HEALTHIER LIVES AND 5645 03:28:09,280 --> 03:28:11,720 PEEP AT RISK OF ACQUIRING HI TO 5646 03:28:11,720 --> 03:28:15,880 PROTECT THEMSELVES. RISING RATES 5647 03:28:15,880 --> 03:28:17,720 OF NEW INFECTIONS OR LOW RATES 5648 03:28:17,720 --> 03:28:20,400 OF VIRAL SUPPRESSION, ARE STILL 5649 03:28:20,400 --> 03:28:23,680 EVIDENT. FOR EXAMPLE, HIV 5650 03:28:23,680 --> 03:28:25,840 DISPARITIES EXIST GLOBALLY IN 5651 03:28:25,840 --> 03:28:28,080 SUB SAHARAN AFRICA AS SEEN ON 5652 03:28:28,080 --> 03:28:29,680 THE MAP ON THE RIGHT AND 5653 03:28:29,680 --> 03:28:30,560 DOMESTICALLY IN SOUTHERN REGION 5654 03:28:30,560 --> 03:28:32,040 AT THE U.S. AS SEEN ON THE MAP 5655 03:28:32,040 --> 03:28:36,920 ON THE LEFT. ALSO 5656 03:28:36,920 --> 03:28:37,760 DISPROPORTIONATELY HIGHER AMONG 5657 03:28:37,760 --> 03:28:39,800 KEEP POPULATIONS AND MANY 5658 03:28:39,800 --> 03:28:42,360 REGIONS OF THE WORLD FOR EXAMPLE 5659 03:28:42,360 --> 03:28:45,120 HIV IN THE U.S. CONTINUES TO 5660 03:28:45,120 --> 03:28:47,720 IMPACT MEN WHO HAVE SEX WITH 5661 03:28:47,720 --> 03:28:48,600 MEN, PARTICULARLY IN THE SOUTH 5662 03:28:48,600 --> 03:28:51,600 AND SUB SAHARAN AFRICA HIV 5663 03:28:51,600 --> 03:28:53,320 CONTINUES TO DISPROPORTIONATELY 5664 03:28:53,320 --> 03:28:56,680 IMPACT ADOLESCENT GIRLS AND 5665 03:28:56,680 --> 03:29:00,160 YOUNG WOMEN. THIS INITIATIVE 5666 03:29:00,160 --> 03:29:01,120 WILL ENCOURAGE BEHAVIORAL AND 5667 03:29:01,120 --> 03:29:02,880 SOCIAL SCIENCE RESEARCH STUDIES 5668 03:29:02,880 --> 03:29:07,400 THAT ARE COMMUNITY CENTERED, 5669 03:29:07,400 --> 03:29:09,160 MULTI-DISCIPLINARY AND 5670 03:29:09,160 --> 03:29:09,800 MULTI-SECTORAL AND MULTI-LEVEL 5671 03:29:09,800 --> 03:29:11,760 TO UNDERSTAND AND ADDRESS 5672 03:29:11,760 --> 03:29:13,480 COMPLEX PSYCHOSOCIAL FACTORS, 5673 03:29:13,480 --> 03:29:16,240 SUCH AS MENTAL HEALTH, TRAUMA 5674 03:29:16,240 --> 03:29:18,040 VIOLENCE. HIV RELATED 5675 03:29:18,040 --> 03:29:24,080 INTERSECTIONAL STIGMA ANIS AND 5676 03:29:24,080 --> 03:29:25,000 DISCRIMINATION MOBILITY AND 5677 03:29:25,000 --> 03:29:26,640 SOCIAL DETERMINANTS OF THE 5678 03:29:26,640 --> 03:29:28,320 HEALTH. HIV SCIENCE AND 5679 03:29:28,320 --> 03:29:29,360 COMMUNICATIONS VERGE ARE 5680 03:29:29,360 --> 03:29:34,000 STRONGLY ENCOURAGED. SO THE 5681 03:29:34,000 --> 03:29:35,680 RESEARCH QUESTIONS THAT COULD BE 5682 03:29:35,680 --> 03:29:37,920 ADDRESSED BY THIS INITIATIVE 5683 03:29:37,920 --> 03:29:39,880 ALIGN WITH THE NIH OFFICE OF 5684 03:29:39,880 --> 03:29:42,120 AIDS RESEARCH PRIORITY AREAS AND 5685 03:29:42,120 --> 03:29:44,080 I WILL OFFER AN EXAMPLE OF A 5686 03:29:44,080 --> 03:29:47,440 POTENTIAL BEHAVIORAL AND SOCIAL 5687 03:29:47,440 --> 03:29:48,200 SCIENCE RESEARCH FOR EACH 5688 03:29:48,200 --> 03:29:52,320 PRIORITY AREAS. SO STARTING WITH 5689 03:29:52,320 --> 03:29:53,720 REDUCING INCIDENCE OF HIV ON THE 5690 03:29:53,720 --> 03:29:56,760 LEFT, STUDIES MIGHT TEST 5691 03:29:56,760 --> 03:29:58,120 INTERVENTIONS DESIGNED TO 5692 03:29:58,120 --> 03:29:59,600 ADDRESS PSYCHOSOCIAL FACTORS TO 5693 03:29:59,600 --> 03:30:01,560 IMPROVE UPTAKE OF HIV TESTING 5694 03:30:01,560 --> 03:30:05,200 AND LINK US TO PREVENTION OR 5695 03:30:05,200 --> 03:30:06,160 CARE. DEVELOPING NEXT GENERATION 5696 03:30:06,160 --> 03:30:09,280 HIV THERAPIES ON THE RIGHT 5697 03:30:09,280 --> 03:30:10,720 STUDIES TEST INNOVATIVE MODELS 5698 03:30:10,720 --> 03:30:14,400 OF CARE, USING LONG ACTING ART 5699 03:30:14,400 --> 03:30:16,760 FOR TREATMENT OR PREVENTION 5700 03:30:16,760 --> 03:30:20,160 AMONG PEOPLE FACING MULTIPLE 5701 03:30:20,160 --> 03:30:23,560 BARRIERS. . CONDUCTING RESEARCH 5702 03:30:23,560 --> 03:30:25,600 TO HIV CURE STUDIES TO 5703 03:30:25,600 --> 03:30:28,200 INVESTIGATE EXPERIENCES OF HIV 5704 03:30:28,200 --> 03:30:29,280 CURE TRIAL PARTICIPANTS TO 5705 03:30:29,280 --> 03:30:33,200 INFORM ETHICAL PROCEDURES. 5706 03:30:33,200 --> 03:30:36,040 ADDRESSING HIV ASSOCIATED 5707 03:30:36,040 --> 03:30:36,720 CO-MORBIDITIES STUDIES MIGHT 5708 03:30:36,720 --> 03:30:39,400 INCLUDE DATA SCIENCE RESEARCH 5709 03:30:39,400 --> 03:30:41,000 THAT ADDRESS MEN DATA NEEDS FOR 5710 03:30:41,000 --> 03:30:41,600 ACHIEVING SUSTAINED VIRAL 5711 03:30:41,600 --> 03:30:43,440 SUPPRESSION. FINALLY ADVANCING 5712 03:30:43,440 --> 03:30:46,560 CROSS CUTTING AREA, STUDIES 5713 03:30:46,560 --> 03:30:47,560 MIGHT TEST COMMUNICATION 5714 03:30:47,560 --> 03:30:48,480 STRATEGIES TO REDUCE 5715 03:30:48,480 --> 03:30:50,440 DISPARITIES. WITH THAT THANK 5716 03:30:50,440 --> 03:30:52,480 YOU FOR YOUR ATTENTION AND 5717 03:30:52,480 --> 03:30:53,760 WELCOME FEEDBACK FROM NIMH 5718 03:30:53,760 --> 03:30:57,800 COUNCIL. 5719 03:30:57,800 --> 03:31:02,760 >> THANK YOU, GREG DISCUSSANTS 5720 03:31:02,760 --> 03:31:05,760 ARE PAMELA COLLINS AND JOSEPH 5721 03:31:05,760 --> 03:31:07,200 TELFAIR. JOSEPH START US OFF. 5722 03:31:07,200 --> 03:31:12,280 >> THANK YOU FOR THE OPPORTUNITY 5723 03:31:12,280 --> 03:31:13,880 TO COMMENT. I VERY MUCH SUPPORT 5724 03:31:13,880 --> 03:31:17,160 THE INITIATIVE. I HAD A LOT OF 5725 03:31:17,160 --> 03:31:22,280 QUESTIONS BUT THIS LAST SLIDE 5726 03:31:22,280 --> 03:31:24,160 CLARIFIED WHAT I WAS CONCERNED 5727 03:31:24,160 --> 03:31:27,200 ABOUT WHICH WAS THE FOCUS ON 5728 03:31:27,200 --> 03:31:29,760 WHAT IS INNOVATION, EXAMPLES OF 5729 03:31:29,760 --> 03:31:32,000 INNOVATION AND AREAS IN WHICH 5730 03:31:32,000 --> 03:31:35,280 YOU CAN BUILD ON EXISTING 5731 03:31:35,280 --> 03:31:37,200 INFORMATION. THAT ANSWERED MY 5732 03:31:37,200 --> 03:31:40,040 QUESTION. THE ONLY THING THAT I 5733 03:31:40,040 --> 03:31:41,600 ACTUALLY HAVE IS -- HAS TO DO 5734 03:31:41,600 --> 03:31:44,000 WITH THE OTHER CHALLENGE WHICH 5735 03:31:44,000 --> 03:31:46,120 IS I THINK A SLIDE MAYBE A SLIDE 5736 03:31:46,120 --> 03:31:50,720 BACK OR SO. THAT HAVE TO DO WITH 5737 03:31:50,720 --> 03:31:55,840 ADDRESSING THE CHALLENGES THAT 5738 03:31:55,840 --> 03:31:57,520 WAS PLENTY OBVIOUS WHICH WAS THE 5739 03:31:57,520 --> 03:32:01,880 MAP THAT INDICATED INCIDENCE AN 5740 03:32:01,880 --> 03:32:03,160 PREVALENCE, THAT MAP, THE 5741 03:32:03,160 --> 03:32:04,920 LEFT-HAND SIDE IN PARTICULAR, 5742 03:32:04,920 --> 03:32:09,200 AND THEN THE CHALLENGES THEN OF 5743 03:32:09,200 --> 03:32:11,120 IMPLEMENTATION, WHAT IS IT GIVEN 5744 03:32:11,120 --> 03:32:13,480 WHAT WE KNOW IN THE YEARS SPENT 5745 03:32:13,480 --> 03:32:15,040 AND TIME SPENT PARTICULARLY 5746 03:32:15,040 --> 03:32:17,160 AROUND PREVENTION, WHAT IS IT 5747 03:32:17,160 --> 03:32:19,560 THAT WE NEED TO REALLY FOCUS ON 5748 03:32:19,560 --> 03:32:21,600 BUILDING ON WHAT WE KNOW THAT 5749 03:32:21,600 --> 03:32:23,360 WILL ADDRESS THE IMPLEMENTATION 5750 03:32:23,360 --> 03:32:25,520 SO THAT WE CAN BEGIN TO 5751 03:32:25,520 --> 03:32:29,040 REALISTICALLY SEE REDUCTIONS IN 5752 03:32:29,040 --> 03:32:31,480 NEW INFECTIONS AND THINGS THAT 5753 03:32:31,480 --> 03:32:32,760 -- EFFORTS THAT ALLOW US TO 5754 03:32:32,760 --> 03:32:34,360 PREVENT THAT. THAT'S MY COMMENT 5755 03:32:34,360 --> 03:32:37,160 ON THAT. I HOPE THAT THAT IS 5756 03:32:37,160 --> 03:32:39,200 WHEN -- I APPRECIATE THE 5757 03:32:39,200 --> 03:32:42,000 EXAMPLES GIVEN, I HOPE THOSE 5758 03:32:42,000 --> 03:32:42,880 EXAMPLES ARE ALSO SOMETHING 5759 03:32:42,880 --> 03:32:46,920 INSTRUCTIVE TO YOU APPLICANTS. 5760 03:32:46,920 --> 03:32:47,240 THANK YOU. 5761 03:32:47,240 --> 03:32:50,440 >> THANK YOU, JOSEPH. PAM, 5762 03:32:50,440 --> 03:32:51,120 ANYTHING TO ADD? 5763 03:32:51,120 --> 03:32:52,760 >> YES, THANK YOU AGAIN FOR THE 5764 03:32:52,760 --> 03:32:54,720 CHANCE TO REVIEW THIS CONCEPT. I 5765 03:32:54,720 --> 03:32:57,160 WAS EXCITED TO SEE IT AND VERY 5766 03:32:57,160 --> 03:32:58,920 SUPPORTIVE OF IT. I WAS 5767 03:32:58,920 --> 03:33:01,840 ENCOURAGED BY THE BREADTH, 5768 03:33:01,840 --> 03:33:02,440 PROVIDES IMPORTANT OPPORTUNITY 5769 03:33:02,440 --> 03:33:04,600 TO UNDERSTAND THE GREATER DETAIL 5770 03:33:04,600 --> 03:33:07,000 WHERE SPECIFIC POPULATIONS AT 5771 03:33:07,000 --> 03:33:08,360 RISK MIGHT FALL OFF THE CARE 5772 03:33:08,360 --> 03:33:09,840 CONTINUUM AND TO FOCUS ATTENTION 5773 03:33:09,840 --> 03:33:12,000 ON DESIGNING OR OPTIMIZING 5774 03:33:12,000 --> 03:33:13,200 INTERVENTIONS FOR THOSE GROUPS. 5775 03:33:13,200 --> 03:33:16,480 T I WAS ALSO CHALLENGED BY ITS 5776 03:33:16,480 --> 03:33:17,760 BREADTH AND WONDER IF YOU CAN 5777 03:33:17,760 --> 03:33:19,800 ADD SPECIFICITY TO GUIDE THE 5778 03:33:19,800 --> 03:33:21,280 KINDS OF SCIENCE YOU ARE LOOKING 5779 03:33:21,280 --> 03:33:23,080 FOR TO HELP APPLICANTS RESPOND 5780 03:33:23,080 --> 03:33:24,480 AND IN PARTICULAR PERHAPS 5781 03:33:24,480 --> 03:33:26,880 EXPLAINING THINGS YOU WERE NOT 5782 03:33:26,880 --> 03:33:29,680 INTERESTED IN. I THINK THE SLIDE 5783 03:33:29,680 --> 03:33:32,720 I FOUND MOST HELPFUL SEEING YOU 5784 03:33:32,720 --> 03:33:34,120 ARE ORGANIZING BY THE OAR 5785 03:33:34,120 --> 03:33:37,160 PRIORITY GROUPS SO MAYBE IN THE 5786 03:33:37,160 --> 03:33:39,640 RFA SOME OF THOSE SUB HEADS 5787 03:33:39,640 --> 03:33:41,720 MIGHT MAKE IT CLEAR FOR PEOPLE 5788 03:33:41,720 --> 03:33:44,200 WHAT KINDS OF SCIENCE YOU ARE 5789 03:33:44,200 --> 03:33:46,960 INTERESTED IN. AS I THOUGHT 5790 03:33:46,960 --> 03:33:49,760 ABOUT THIS BROAD SET OF 5791 03:33:49,760 --> 03:33:52,160 QUESTIONS, I WAS THINKING IN 5792 03:33:52,160 --> 03:33:53,440 TERMS OF WHAT DO WE UNDERSTAND 5793 03:33:53,440 --> 03:33:55,040 ABOUT PREVENTION, THERE'S GREAT 5794 03:33:55,040 --> 03:33:57,080 EVIDENCE FOR EXAMPLE FOR 5795 03:33:57,080 --> 03:33:58,080 PSYCHOSOCIAL INTERVENTIONS THAT 5796 03:33:58,080 --> 03:33:59,760 REDUCE HIV RISK AS WELL AS 5797 03:33:59,760 --> 03:34:02,760 REDUCING SYMPTOMS OF MENTAL 5798 03:34:02,760 --> 03:34:03,720 DISORDERS WHEN EVIDENCE BASED 5799 03:34:03,720 --> 03:34:05,000 MENTAL HEALTH INTERVENTIONS ARE 5800 03:34:05,000 --> 03:34:07,600 INTEGRATED. DO WE KNOW WHAT 5801 03:34:07,600 --> 03:34:09,040 ENABLES BROADER IMPLEMENTATION 5802 03:34:09,040 --> 03:34:11,280 OF THESE INTERVENTIONS. WITH 5803 03:34:11,280 --> 03:34:12,920 THIS CONCEPT ALSO BE INTERESTED 5804 03:34:12,920 --> 03:34:14,280 IN MORE DATA ON STRUCTURAL 5805 03:34:14,280 --> 03:34:17,760 INTERVENTIONS AND THEIR ROLE IN 5806 03:34:17,760 --> 03:34:18,520 HIV PREVENTION. . 5807 03:34:18,520 --> 03:34:20,320 I ALSO HAD A QUESTION ABOUT 5808 03:34:20,320 --> 03:34:23,240 SOCIETAL OR POLICY ENABLERS 5809 03:34:23,240 --> 03:34:26,720 WHICH FOR EXAMPLE THINGS THAT 5810 03:34:26,720 --> 03:34:28,240 INFLUENCE WHETHER GROUPS HAVE 5811 03:34:28,240 --> 03:34:29,240 ACCESS TO PREP IN THE UNITED 5812 03:34:29,240 --> 03:34:31,520 STATES AND WHICH GROUPS ARE MORE 5813 03:34:31,520 --> 03:34:32,720 SYSTEMATICALLY DENIED ACCESS 5814 03:34:32,720 --> 03:34:34,080 BECAUSE OF INSURANCE POLICIES, 5815 03:34:34,080 --> 03:34:36,320 ET CETERA. OR UNDERSTANDING HOW 5816 03:34:36,320 --> 03:34:38,120 DECRIMINALIZATION OF KEY 5817 03:34:38,120 --> 03:34:39,520 POPULATIONS OR THEIR BEHAVIORS 5818 03:34:39,520 --> 03:34:40,800 INFLUENCE UPTAKE OF PREVENTION 5819 03:34:40,800 --> 03:34:43,120 TESTING AND CARE. MIGHT THERE BE 5820 03:34:43,120 --> 03:34:44,400 OPPORTUNITIES FOR NATURAL 5821 03:34:44,400 --> 03:34:46,160 EXPERIMENTS IN SETTINGS WHERE 5822 03:34:46,160 --> 03:34:51,120 SUCH POLICY REFORM IS UNDERWAY. 5823 03:34:51,120 --> 03:34:55,760 SIMILARLY, ARE YOU INTERESTED IN 5824 03:34:55,760 --> 03:34:59,040 PMTCT PERINATAL DEPRESSION AND 5825 03:34:59,040 --> 03:35:01,760 MANAGEMENT OF PMPCT AND BROADLY 5826 03:35:01,760 --> 03:35:03,080 WONDERING HOW MUCH ISSUE OF 5827 03:35:03,080 --> 03:35:04,880 INTEGRATION. I SAW THAT IS ONE 5828 03:35:04,880 --> 03:35:08,800 OF THE AREAS FOR OAR HOW MUCH 5829 03:35:08,800 --> 03:35:11,360 INTEGRATION WOULD BE EMPHASIZED 5830 03:35:11,360 --> 03:35:13,080 SO I THINK MORE SPECIFICALLY IS 5831 03:35:13,080 --> 03:35:14,960 THERE -- IS THERE SOMETHING YOU 5832 03:35:14,960 --> 03:35:17,520 DON'T WANT IN THIS RFA OR 5833 03:35:17,520 --> 03:35:18,800 WHATEVER THIS MAY BE, IT WOULD 5834 03:35:18,800 --> 03:35:19,680 BE IMPORTANT TO SPECIFY THAT. 5835 03:35:19,680 --> 03:35:21,800 THANK YOU. 5836 03:35:21,800 --> 03:35:22,560 >> DO YOU HAVE ANY RESPONSE TO 5837 03:35:22,560 --> 03:35:24,760 ISSUE OF THE BREADTH? 5838 03:35:24,760 --> 03:35:28,200 >> I DO. THIS IS MEANT TO BE A 5839 03:35:28,200 --> 03:35:29,920 VERY BROAD INITIATIVE FOR THE 5840 03:35:29,920 --> 03:35:32,560 BEHAVIORAL SOCIAL SCIENCE 5841 03:35:32,560 --> 03:35:33,920 RESEARCH THAT OUR DIVISION 5842 03:35:33,920 --> 03:35:37,200 SUPPORTS. THAT REALLY RUNS 5843 03:35:37,200 --> 03:35:40,640 ACROSS OUR DIVISION. SO THESE 5844 03:35:40,640 --> 03:35:43,480 WILL BE VERY BROAD INITIATIVES 5845 03:35:43,480 --> 03:35:47,720 TO SIGNAL TO THE COMMUNITY AND 5846 03:35:47,720 --> 03:35:49,880 TO IMPLEMENTERS AND RESEARCHERS 5847 03:35:49,880 --> 03:35:51,520 ABOUT OUR PRIORITIES AS THEY 5848 03:35:51,520 --> 03:35:52,960 ALIGN WITH NIH OFFICE OF AIDS 5849 03:35:52,960 --> 03:35:55,320 RESEARCH. 5850 03:35:55,320 --> 03:35:56,760 >> ANY QUESTIONS OR COMMENTS 5851 03:35:56,760 --> 03:36:04,160 FROM OTHER MEMBERS OF THE 5852 03:36:04,160 --> 03:36:09,200 COUNCIL? 5853 03:36:09,200 --> 03:36:10,600 >> I'M ENTHUSIASTIC ABOUT THIS 5854 03:36:10,600 --> 03:36:14,680 AS WELL, AS I WAS GOING THROUGH 5855 03:36:14,680 --> 03:36:22,080 IT THE IDEA THAT HIV IS A BRAIN 5856 03:36:22,080 --> 03:36:27,640 DISORDER OR CREATED DISORDER 5857 03:36:27,640 --> 03:36:30,960 VERY ON IN THE EFFECTIVE PROCESS 5858 03:36:30,960 --> 03:36:33,840 AND HOW THAT CONCEPT OF IT BEING 5859 03:36:33,840 --> 03:36:36,240 A BRAIN DISORDER IMPACTS THE 5860 03:36:36,240 --> 03:36:41,080 CARE CONTINUUM OUTCOMES. WAS 5861 03:36:41,080 --> 03:36:42,720 SOMETHING I THOUGHT THAT COULD 5862 03:36:42,720 --> 03:36:49,920 BE EMPHASIZED A LITTLE BIT MORE 5863 03:36:49,920 --> 03:36:51,280 >> THANK YOU. ANY OTHER COMMENTS 5864 03:36:51,280 --> 03:36:53,920 OR QUESTIONS? THEN WE WILL CLOSE 5865 03:36:53,920 --> 03:36:55,560 THIS PART OF THE MEETING. THANK 5866 03:36:55,560 --> 03:36:58,120 YOU VERY MUCH TO ALL THE 5867 03:36:58,120 --> 03:36:58,800 DISCUSSANTS AND ALL OTHER 5868 03:36:58,800 --> 03:37:00,360 COMMENTS. WE WILL MOVE FORWARD 5869 03:37:00,360 --> 03:37:02,520 WITH THESE CONCEPTS WITH THOSE 5870 03:37:02,520 --> 03:37:06,520 QUESTIONS AND COMMENTS IN MIND. 5871 03:37:06,520 --> 03:37:09,880 AND OF COURSE DEPENDING UPON THE 5872 03:37:09,880 --> 03:37:12,240 AVAILABILITY OF FUNDS, THE 5873 03:37:12,240 --> 03:37:13,760 SPECIFICS THAT WILL BE WORKED ON 5874 03:37:13,760 --> 03:37:16,200 IN THE FUTURE. TYPICALLY WE 5875 03:37:16,200 --> 03:37:18,000 CLOSE OUR OPEN SESSION WITH 5876 03:37:18,000 --> 03:37:19,840 PUBLIC COMMENTS BUT WE CONTINUE 5877 03:37:19,840 --> 03:37:22,240 TO BE UNABLE TO ACOME DATE THOSE 5878 03:37:22,240 --> 03:37:29,120 DURING THIS ERA OF LIVE VIRTUAL 5879 03:37:29,120 --> 03:37:30,520 COUNCIL. HOWEVER PUBLIC COMMENTS 5880 03:37:30,520 --> 03:37:32,000 WERE RECEIVED PRIOR TO THE 5881 03:37:32,000 --> 03:37:33,720 MEETING WERE CONVEYED TO IN 5882 03:37:33,720 --> 03:37:35,120 ADDITION THESE COMMENTS WILL BE 5883 03:37:35,120 --> 03:37:38,520 APPENDED TO OUR MEETING MINUTES 5884 03:37:38,520 --> 03:37:40,920 THANK YOU ALL FOR THIS ATTENDING 5885 03:37:40,920 --> 03:37:42,400 THIS OPEN SESSION. TRACY, DO YOU 5886 03:37:42,400 --> 03:37:43,920 HAVE ANY CLOSING WORDS OR 5887 03:37:43,920 --> 03:37:46,600 REMINDERS ABOUT TOMORROW FOR US 5888 03:37:46,600 --> 03:37:48,040 >> JUST GET A GOOD NIGHT SLEEP 5889 03:37:48,040 --> 03:37:50,640 AND WE WILL START PROMPTLY AT 12 5890 03:37:50,640 --> 03:37:52,400 NOON EASTERN TIME TOMORROW. 5891 03:37:52,400 --> 03:37:54,840 Y'ALL RECEIVED YOUR VIDEO LINKS 5892 03:37:54,840 --> 03:37:55,720 PERSONALIZED LINKS FOR THE 5893 03:37:55,720 --> 03:37:57,360 CLOSED SESSION SO WE LOOK 5894 03:37:57,360 --> 03:37:58,960 FORWARD TO REJOINING THEN. 5895 03:37:58,960 --> 03:38:00,920 >> ALL RIGHT. THANK YOU, THAT 5896 03:38:00,920 --> 03:38:01,920 ALREADY FOR THE CLOSED GRANT 5897 03:38:01,920 --> 03:38:03,160 REVIEW SESSION OF COUNCIL. LOOK 5898 03:38:03,160 --> 03:38:04,240 FORWARD TO SEEING COUNCIL 5899 03:38:04,240 --> 03:38:05,760 MEMBERS THEN AND TO PUBLIC WHO 5900 03:38:05,760 --> 03:38:06,360 JOINED US, THANK YOU VERY MUCH 5901 03:38:06,360 --> 03:38:08,640 FOR JOINING. HOPEFULLY YOU FOUND 5902 03:38:08,640 --> 03:38:11,400 IT INFORMATIVE AND ENTERTAINING 5903 03:38:11,400 --> 03:38:13,000 AS WELL. SEE EVERYONE ELSE TO 5904 03:38:13,000 --> 03:38:23,440 YOUR KNOWLEDGE. BYE-BYE.