1 00:00:06,072 --> 00:00:08,742 >> HELLO AND WELCOME TO THE 2 00:00:08,808 --> 00:00:10,510 273rd MEETING OF THE NATIONAL 3 00:00:10,577 --> 00:00:11,811 ADVISORY MENTAL HEALTH COUNCIL. 4 00:00:11,878 --> 00:00:13,880 I AM JOSHUA GORDON, DIRECTOR OF 5 00:00:13,947 --> 00:00:15,782 THE NATIONAL INSTITUTE OF MENTAL 6 00:00:15,849 --> 00:00:16,116 HEALTH. 7 00:00:16,182 --> 00:00:17,751 I'D LIKE TO THANK YOU ALL FOR 8 00:00:17,817 --> 00:00:19,519 JOINING OUR COUNCIL TODAY. 9 00:00:19,586 --> 00:00:22,655 WE HAVE A WONDERFUL, STRONG, 10 00:00:22,722 --> 00:00:24,324 IN-PERSON PRESENCE OF MANY OF 11 00:00:24,391 --> 00:00:26,860 OUR COUNCIL MEMBERS. 12 00:00:26,926 --> 00:00:28,461 WE ALSO HAVE MANY ATTENDEES 13 00:00:28,528 --> 00:00:30,330 JOINING US ONLINE AND WATCHING 14 00:00:30,397 --> 00:00:33,500 THE NIH VIDEOCAST. 15 00:00:33,566 --> 00:00:35,135 AS A REMINDER, OUR COUNCIL 16 00:00:35,201 --> 00:00:37,003 MEETING IS A TIME FOR 17 00:00:37,070 --> 00:00:38,772 INFORMATION EXCHANGE BETWEEN 18 00:00:38,838 --> 00:00:41,174 INSTITUTE STAFF AND COUNCIL 19 00:00:41,241 --> 00:00:42,609 MEMBERS, AS WELL AS AN 20 00:00:42,675 --> 00:00:43,777 OPPORTUNITY FOR THE COUNCIL TO 21 00:00:43,843 --> 00:00:45,879 PROVIDE FEEDBACK TO NIMH AND FOR 22 00:00:45,945 --> 00:00:47,847 ALL OF US TO COMMUNICATE THROUGH 23 00:00:47,914 --> 00:00:49,382 THE VIDEOCAST WITH THE GENERAL 24 00:00:49,449 --> 00:00:50,350 PUBLIC. 25 00:00:50,417 --> 00:00:51,584 WE HAVE A FULL SCHEDULE TODAY 26 00:00:51,651 --> 00:00:52,852 AND I THANK YOU FOR MAKING TIME 27 00:00:52,919 --> 00:00:54,854 TO PARTICIPATE IN THIS OPEN 28 00:00:54,921 --> 00:00:56,556 SESSION OF THE COUNCIL, AS WELL 29 00:00:56,623 --> 00:00:58,158 AS THE CLOSED SESSION TOMORROW 30 00:00:58,224 --> 00:01:01,394 AT WHICH WE'LL DISCUSS GRANTS 31 00:01:01,461 --> 00:01:05,231 THAT ARE UP FOR -- PROPOSED FOR 32 00:01:05,298 --> 00:01:05,999 FUNDING. 33 00:01:06,065 --> 00:01:07,133 BEFORE WE MOVE INTO THE BUSINESS 34 00:01:07,200 --> 00:01:08,768 OF THE MEETING, I WANT TO REMIND 35 00:01:08,835 --> 00:01:11,137 YOU OF A FEW LOGISTICAL ITEMS. 36 00:01:11,204 --> 00:01:13,206 THE OPEN SESSION IS BEING 37 00:01:13,273 --> 00:01:15,074 VIDEOCAST BROADLY TO THE NIH 38 00:01:15,141 --> 00:01:16,476 COMMUNITY AND THE VIEWING 39 00:01:16,543 --> 00:01:17,811 PUBLIC, ALLOWING PEOPLE TO WATCH 40 00:01:17,877 --> 00:01:21,080 AND LISTEN REMOTELY. 41 00:01:21,147 --> 00:01:22,182 THE MEETING IS ALSO BEING 42 00:01:22,248 --> 00:01:23,383 RECORDED WHICH WILL ALLOW 43 00:01:23,450 --> 00:01:26,352 VIEWING ON DEMAND AT A LATER 44 00:01:26,419 --> 00:01:28,955 DATE. 45 00:01:29,022 --> 00:01:30,056 WE ENCOURAGE COUNCIL MEMBERS TO 46 00:01:30,123 --> 00:01:31,357 LOG INTO ZOOM AND KEEP YOUR 47 00:01:31,424 --> 00:01:32,892 VIDEO ON THROUGHOUT THE MEETING 48 00:01:32,959 --> 00:01:34,427 SO THAT YOU CAN BE SEEN BY THOSE 49 00:01:34,494 --> 00:01:37,063 OUTSIDE OF THE MEETING ROOM. 50 00:01:37,130 --> 00:01:38,798 WHEN YOU DO LOG IN, PLEASE DO 51 00:01:38,865 --> 00:01:40,333 NOT CONNECT TO AUDIO THROUGH 52 00:01:40,400 --> 00:01:41,000 YOUR COMPUTER. 53 00:01:41,067 --> 00:01:43,069 ALL OF THE AUDIO WILL TAKE PLACE 54 00:01:43,136 --> 00:01:44,504 THROUGH THE MICROPHONES AND THE 55 00:01:44,571 --> 00:01:48,007 ROOM SPEAKERS. 56 00:01:48,074 --> 00:01:49,108 COUNCIL MEMBERS IN THE ROOM 57 00:01:49,175 --> 00:01:50,510 SHOULD USE THE TABLE MICROPHONE 58 00:01:50,577 --> 00:01:51,711 WHEN SPEAKING. 59 00:01:51,778 --> 00:01:53,246 AND REMEMBER TO PUSH THE BUTTON 60 00:01:53,313 --> 00:01:54,981 UNTIL YOU SEE THE LITTLE GREEN 61 00:01:55,048 --> 00:01:56,316 LIGHT GO ON AND REMEMBER WHEN 62 00:01:56,382 --> 00:01:58,585 YOU'RE DONE SPEAKING TO PLEASE 63 00:01:58,651 --> 00:01:59,352 PUSH IT AGAIN. 64 00:01:59,419 --> 00:02:01,321 IT SHOULD CHANGE BACK TO RED, 65 00:02:01,387 --> 00:02:03,189 INDICATING THAT YOUR MICROPHONE 66 00:02:03,256 --> 00:02:04,724 IS SHUT OFF. 67 00:02:04,791 --> 00:02:06,359 MEMBERS ATTENDING VIRTUALLY 68 00:02:06,426 --> 00:02:08,228 SHOULD UNMUTE TO SPEAK AND 69 00:02:08,294 --> 00:02:09,996 PLEASE MUTE AGAIN WHEN NOT 70 00:02:10,063 --> 00:02:12,499 SPEAKING TO DIMINISH BACKGROUND 71 00:02:12,565 --> 00:02:15,768 NOISE. 72 00:02:15,835 --> 00:02:18,771 IF ANY USING TELEPHONE, YOU CAN 73 00:02:18,838 --> 00:02:20,473 PRESS STAR 6 TO MUTE AND UNMUTE. 74 00:02:20,540 --> 00:02:22,575 WE ASK THAT ALL MEMBERS PLEASE 75 00:02:22,642 --> 00:02:24,511 REFRAIN FROM USE OF THE CHAT 76 00:02:24,577 --> 00:02:26,045 FUNCTION IN ZOOM. 77 00:02:26,112 --> 00:02:28,915 PLEASE RESERVE THAT CHAT 78 00:02:28,982 --> 00:02:30,149 FUNCTION TO COMMUNICATE WITH 79 00:02:30,216 --> 00:02:31,417 ZOOM HOSTS REGARDING ANY 80 00:02:31,484 --> 00:02:32,619 TECHNICAL ISSUES AND PLEASE 81 00:02:32,685 --> 00:02:33,620 REMEMBER THE CHAT FUNCTION IS 82 00:02:33,686 --> 00:02:35,588 NOT A PRIVATE CHANNEL, IT IS A 83 00:02:35,655 --> 00:02:36,556 PUBLIC CHANNEL JUST LIKE 84 00:02:36,623 --> 00:02:40,827 EVERYTHING ELSE. 85 00:02:40,894 --> 00:02:42,562 WHEN WE CALL FOR A VOTE 86 00:02:42,629 --> 00:02:43,563 COUNCILMEMBERS SHOULD USE THE 87 00:02:43,630 --> 00:02:44,864 RAISE HAND FUNCTION IN ZOOM. 88 00:02:44,931 --> 00:02:47,066 IT MAY BE LOCATED IN THE ZOOM 89 00:02:47,133 --> 00:02:48,701 PARTICIPANT MENU, OR AT THE 90 00:02:48,768 --> 00:02:51,771 BOTTOM UNDER THE REACTIONS MENU. 91 00:02:51,838 --> 00:02:53,172 VOTING COUNCILMEMBERS WHO ARE 92 00:02:53,239 --> 00:02:57,677 JOINING BY PHONE SHOULD UNMUTE 93 00:02:57,744 --> 00:02:59,078 BY PRESSING STAR 6 AS I 94 00:02:59,145 --> 00:03:00,413 MENTIONED BEFORE SO WE CAN 95 00:03:00,480 --> 00:03:02,916 CAPTURE YOUR VOTE BY VOICE. 96 00:03:02,982 --> 00:03:04,551 IF YOU EXPERIENCE CONNECTIVITY 97 00:03:04,617 --> 00:03:05,785 ISSUES, YOU HAVE A PHONE NUMBER 98 00:03:05,852 --> 00:03:06,953 TO CALL IN. 99 00:03:07,020 --> 00:03:09,489 PLEASE REFER TO YOUR PERSONAL 100 00:03:09,556 --> 00:03:18,798 ZOOM EY EYE TIN R ITINERARY FOR. 101 00:03:18,865 --> 00:03:21,167 THE NEXT ITEM IS TO ASK FOR 102 00:03:21,234 --> 00:03:22,835 COMMENTS OR CORRECTIONS TO THE 103 00:03:22,902 --> 00:03:24,938 MINUTES FROM OR LAST MEETING. 104 00:03:25,004 --> 00:03:25,872 COPIES OF THOSE MINUTES WERE 105 00:03:25,939 --> 00:03:27,974 PROVIDED TO YOU IN ADVANCE OF 106 00:03:28,041 --> 00:03:28,942 THE MEETING. 107 00:03:29,008 --> 00:03:30,476 I'LL TURN IT OVER TO TRACY TO 108 00:03:30,543 --> 00:03:31,344 CONDUCT THE VOTE ON THAT. 109 00:03:31,411 --> 00:03:32,111 >> THANK YOU. 110 00:03:32,178 --> 00:03:34,981 SO I'M LOOKING FOR A MOTION FOR 111 00:03:35,048 --> 00:03:37,283 APPROVAL OF THE JANUARY 2024 112 00:03:37,350 --> 00:03:39,218 DRAFT MINUTES. 113 00:03:39,285 --> 00:03:40,853 I SEE ONE AND A SECOND MOTION AS 114 00:03:40,920 --> 00:03:41,521 WELL. 115 00:03:41,588 --> 00:03:44,691 ALL IN FAVOR OF ACCEPTING THE 116 00:03:44,757 --> 00:03:46,793 MINUTES AS WRITTEN, PLEASE RAISE 117 00:03:46,859 --> 00:03:53,032 HAND. 118 00:03:53,099 --> 00:03:55,201 IT'S BEST TO DO IT IN ZOOM BUT 119 00:03:55,268 --> 00:03:56,736 MOST OF YOU ARE IN THE ROOM SO 120 00:03:56,803 --> 00:03:58,137 WE CAN DO IT EITHER WAY. 121 00:03:58,204 --> 00:04:02,308 ALL RIGHT. 122 00:04:02,375 --> 00:04:04,377 IT LOOKS LIKE WE HAVE ALL THE 123 00:04:04,444 --> 00:04:04,611 VOTERS. 124 00:04:04,677 --> 00:04:06,045 YOU CAN PUT YOUR HANDS DOWN 125 00:04:06,112 --> 00:04:09,082 VIRTUALLY. 126 00:04:09,148 --> 00:04:10,083 ANY OPPOSED TO ACCEPTING THE 127 00:04:10,149 --> 00:04:12,719 MINUTES? 128 00:04:12,785 --> 00:04:13,453 ALL RIGHT. 129 00:04:13,519 --> 00:04:14,053 ANY AB SENGSES? 130 00:04:14,120 --> 00:04:19,392 ABSTENTIONS?OUR MINUTES ARE ACCK 131 00:04:19,459 --> 00:04:19,559 YOU. 132 00:04:19,626 --> 00:04:19,926 >> THANK YOU. 133 00:04:19,993 --> 00:04:21,995 THE NEXT ITEM ON THE AGENDA IS 134 00:04:22,061 --> 00:04:25,298 THE NIMH DIRECTOR'S UPDATE. 135 00:04:25,365 --> 00:04:35,775 SHOULD I USE THE PODIUM? 136 00:04:55,395 --> 00:04:56,562 AGAIN THANK YOU AND WELCOME AND 137 00:04:56,629 --> 00:04:58,765 IT'S MY PLEASURE AND IT'S A 138 00:04:58,831 --> 00:04:59,866 BITTERSWEET PLEASURE SINCE IT'S 139 00:04:59,932 --> 00:05:02,368 MY LAST TIME TO PROVIDE THIS 140 00:05:02,435 --> 00:05:05,204 NIMH DIRECTOR'S UPDATE FOR THE 141 00:05:05,271 --> 00:05:06,139 NATIONAL ADVISORY MENTAL HEALTH 142 00:05:06,205 --> 00:05:06,506 COUNCIL. 143 00:05:06,572 --> 00:05:08,374 AS USUAL, WE WILL START WITH A 144 00:05:08,441 --> 00:05:10,343 DISCUSSION OF CONGRESSIONAL 145 00:05:10,410 --> 00:05:11,778 INTERACTIONS, GIVE YOU UPDATES 146 00:05:11,844 --> 00:05:12,779 REGARDING APPROPRIATIONS AND 147 00:05:12,845 --> 00:05:13,012 BUDGET. 148 00:05:13,079 --> 00:05:15,815 WE NOW HAVE A BUDGET, VERY 149 00:05:15,882 --> 00:05:16,482 PLEASED, AS WELL AS TO TALK 150 00:05:16,549 --> 00:05:20,286 ABOUT SOME UPDATES FROM HHS AND 151 00:05:20,353 --> 00:05:21,921 NIH, AS WELL AS NIMH NEWS, AND 152 00:05:21,988 --> 00:05:23,589 THEN WE'LL CLOSE WITH A FEW 153 00:05:23,656 --> 00:05:28,594 SCIENCE HIGHLIGHTS. 154 00:05:28,661 --> 00:05:30,129 WE'VE BEEN BUSY IN CONGRESS. 155 00:05:30,196 --> 00:05:32,432 BETWEEN FEBRUARY AND MAY 2024, 156 00:05:32,498 --> 00:05:34,400 NIMH STAFF PARTICIPATED IN 157 00:05:34,467 --> 00:05:36,035 NUMEROUS CONGRESSIONAL BRIEFINGS 158 00:05:36,102 --> 00:05:37,270 AND RESPONDED TO INFORMATION 159 00:05:37,336 --> 00:05:38,771 REQUESTS FROM OVER 10 MEMBERS OF 160 00:05:38,838 --> 00:05:41,541 CONGRESS AND THEIR STAFF. 161 00:05:41,607 --> 00:05:43,576 THE TOPICS THAT OUR LEGISLATORS 162 00:05:43,643 --> 00:05:44,744 ARE INTERESTED IN INCLUDE 163 00:05:44,811 --> 00:05:45,912 GENERAL HEALTH RESEARCH, MENTAL 164 00:05:45,978 --> 00:05:47,747 HEALTH AND SLEEP RESEARCH, 165 00:05:47,814 --> 00:05:49,615 CHILDREN'S MENTAL HEALTH, 166 00:05:49,682 --> 00:05:52,351 SUICIDE PREVENTION, HEALTH 167 00:05:52,418 --> 00:05:54,954 DISPARITIES, AND NOVEL TREATMENT 168 00:05:55,021 --> 00:05:56,956 APPROACHES SUCH AS TRANSCRANIAL 169 00:05:57,023 --> 00:06:00,226 MAMAGNETIC STIMULATION AND 170 00:06:00,293 --> 00:06:00,993 ULTRASOUND. 171 00:06:01,060 --> 00:06:02,195 NIH LEADERSHIP ALSO PARTICIPATED 172 00:06:02,261 --> 00:06:04,030 IN A STAFF ROUNDTABLE HOSTED BY 173 00:06:04,097 --> 00:06:05,598 THE SENATE AND CONGRESSIONAL 174 00:06:05,665 --> 00:06:07,667 MENTAL HEALTH CAUCUSES, 175 00:06:07,734 --> 00:06:09,168 ALONGSIDE REPRESENTATIVES FROM 176 00:06:09,235 --> 00:06:12,138 OTHER FEDERAL AGENCIES IN THE 177 00:06:12,205 --> 00:06:15,675 MENTAL HEALTH SPACE. 178 00:06:15,742 --> 00:06:17,810 FINALLY, NIMH STAFF ATTENDED AND 179 00:06:17,877 --> 00:06:18,911 PARTICIPATED IN CONGRESSIONAL 180 00:06:18,978 --> 00:06:21,681 EVENTS INCLUDING A 10-YEAR 181 00:06:21,748 --> 00:06:22,982 ANNIVERSARY RECEPTION FOR 182 00:06:23,049 --> 00:06:24,383 ADVANCING CURES TODAY FOR NIH, 183 00:06:24,450 --> 00:06:27,286 AND THE NIMH 75TH ANNIVERSARY 184 00:06:27,353 --> 00:06:28,988 CELEBRATION ON CAPITOL HILL 185 00:06:29,055 --> 00:06:31,124 HOSTED BY THE FRIENDS OF THE 186 00:06:31,190 --> 00:06:32,625 NATIONATIONAL INSTITUTE OF MENTL 187 00:06:32,692 --> 00:06:32,859 HEALTH. 188 00:06:32,925 --> 00:06:34,927 AT THAT CELEBRATION, WE WERE 189 00:06:34,994 --> 00:06:37,964 DELIGHTED TO HAVE SENATOR AMY 190 00:06:38,030 --> 00:06:41,367 KLOBUCHAR LAUNCH US OFF AND HOST 191 00:06:41,434 --> 00:06:42,969 US AS WELL AS THE CONGRESSIONAL 192 00:06:43,035 --> 00:06:44,203 NEUROSCIENCE CAUCUS AS A HOST AS 193 00:06:44,270 --> 00:06:50,209 WELL. 194 00:06:50,276 --> 00:06:50,877 APPROPRIATIONS AND BUDGET 195 00:06:50,943 --> 00:06:52,879 UPDATES. 196 00:06:52,945 --> 00:06:54,046 MARCH 9TH, 2024, PRESIDENT BIDEN 197 00:06:54,113 --> 00:06:55,348 SIGNED THE CONSOLIDATED 198 00:06:55,414 --> 00:06:58,417 APPROPRIATIONS ACT OF 2024, AND 199 00:06:58,484 --> 00:07:00,586 ON MARCH 23RD, SIGNED A FURTHER 200 00:07:00,653 --> 00:07:02,054 CONSOLIDATED APPROPRIATIONS. 201 00:07:02,121 --> 00:07:03,890 THESE TWO ACTS FUNDED THE 202 00:07:03,956 --> 00:07:04,857 FEDERAL GOVERNMENT FOR THE 203 00:07:04,924 --> 00:07:08,261 REMAINDER OF THE FISCAL YEAR. 204 00:07:08,327 --> 00:07:10,530 IT WAS A CHALLENGING BUDGET YEAR 205 00:07:10,596 --> 00:07:13,699 FOR NIH IN GENERAL. 206 00:07:13,766 --> 00:07:16,569 WHERE THE DOLLARS FOR NIH HAD A 207 00:07:16,636 --> 00:07:20,706 VERY MODEST INCREASE, GIVEN THE 208 00:07:20,773 --> 00:07:23,676 TIGHT CONSTRAINTS NEGOTIATED 209 00:07:23,743 --> 00:07:27,079 LAST YEAR BY THE PRESIDENT AND 210 00:07:27,146 --> 00:07:28,247 CONGRESSIONAL LEADERSHIP. 211 00:07:28,314 --> 00:07:30,449 THE GOOD NEWS FROM THE MENTAL 212 00:07:30,516 --> 00:07:32,985 HEALTH RESEARCH PERSPECTIVE IS 213 00:07:33,052 --> 00:07:34,487 THAT THE RECOGNITION THAT WE ARE 214 00:07:34,554 --> 00:07:36,923 IN A MENTAL HEALTH CRISIS, 215 00:07:36,989 --> 00:07:40,393 COUPLED WITH THE WORK THAT 216 00:07:40,459 --> 00:07:42,495 CONGRESS HAS DONE UNDERSTANDING 217 00:07:42,562 --> 00:07:45,765 THE MENTAL HEALTH RESEARCH 218 00:07:45,832 --> 00:07:47,733 LANDSCAPE AIDED BY A LOT OF 219 00:07:47,800 --> 00:07:49,468 COMMUNICATION WITH NIMH, 220 00:07:49,535 --> 00:07:52,872 RESULTED IN CONGRESS GIVING A 221 00:07:52,939 --> 00:07:54,173 $75 MILLION INCREASE TO OUR 222 00:07:54,240 --> 00:07:56,175 BUDGET THIS YEAR, WHEN THE 223 00:07:56,242 --> 00:07:58,277 MAJORITY OF INSTITUTES AT NIH 224 00:07:58,344 --> 00:08:01,414 WERE FLAT. 225 00:08:01,480 --> 00:08:04,951 THE INCREASE OF $75 MILLION WAS 226 00:08:05,017 --> 00:08:06,219 WELCOME, AND IT WAS TARGETED, 227 00:08:06,285 --> 00:08:07,753 QUOTE, TO SUPPORT RESEARCH 228 00:08:07,820 --> 00:08:09,288 FOCUSED ON DEVELOPING TARGETED 229 00:08:09,355 --> 00:08:10,489 PREVENTION AND TREATMENT FOR 230 00:08:10,556 --> 00:08:13,159 MENTAL ILLNESSES. 231 00:08:13,226 --> 00:08:15,428 THE SPECIFIC AREAS THAT WERE 232 00:08:15,494 --> 00:08:17,496 MENTIONED IN THE LEGISLATIVE 233 00:08:17,563 --> 00:08:19,365 LANGUAGE WERE CONSISTENT WITH 234 00:08:19,432 --> 00:08:21,868 THE LANGUAGE THAT WE HAD USED IN 235 00:08:21,934 --> 00:08:23,936 WORKING WITH CONGRESS TO 236 00:08:24,003 --> 00:08:25,037 IDENTIFY PRIORITY AREAS FOR 237 00:08:25,104 --> 00:08:28,007 EXPANSION. 238 00:08:28,074 --> 00:08:29,075 AND MANY OF THE PROGRAMS THAT 239 00:08:29,141 --> 00:08:30,243 YOU'LL BE TALKING ABOUT TOMORROW 240 00:08:30,309 --> 00:08:33,112 IN THE CLOSED SESSION ARE A 241 00:08:33,179 --> 00:08:36,749 DIRECT RESULT OF THE PROJECTS 242 00:08:36,816 --> 00:08:39,151 SUPPORTED BY THIS $75 MILLION 243 00:08:39,218 --> 00:08:39,418 INCREASE. 244 00:08:39,485 --> 00:08:41,420 IT INCLUDES FUNDS TO SUPPORT 245 00:08:41,487 --> 00:08:44,290 PRECISION PSYCHIATRY, LEARNING 246 00:08:44,357 --> 00:08:46,025 HEALTHCARE, AND MANY OTHER 247 00:08:46,092 --> 00:08:47,126 PRIORITIES, ESPECIALLY THOSE 248 00:08:47,193 --> 00:08:49,528 ASSOCIATED WITH YOUTH MENTAL 249 00:08:49,595 --> 00:08:49,962 HEALTH. 250 00:08:50,029 --> 00:08:51,397 AND WE'LL TALK MORE ABOUT THAT 251 00:08:51,464 --> 00:08:52,498 TOMORROW, BUT WE'RE REALLY 252 00:08:52,565 --> 00:08:54,567 PLEASED THAT IN THIS CHALLENGING 253 00:08:54,634 --> 00:08:57,303 BUDGET YEAR, CONGRESS FELT IT 254 00:08:57,370 --> 00:08:58,938 IMPORTANT ENOUGH NONETHELESS TO 255 00:08:59,005 --> 00:09:01,107 INCREASE THE RESOURCES AVAILABLE 256 00:09:01,173 --> 00:09:02,341 FOR MENTAL HEALTH RESEARCH 257 00:09:02,408 --> 00:09:06,045 THROUGH THE NIMH BUDGET. 258 00:09:06,112 --> 00:09:07,280 THE PRESIDENT HAS PROPOSED A 259 00:09:07,346 --> 00:09:10,216 FISCAL YEAR 2025 BUDGET WHICH 260 00:09:10,283 --> 00:09:12,051 REQUESTS AN ADDITIONAL INCREASE 261 00:09:12,118 --> 00:09:16,422 TO MENTAL HEALTH RESEARCH AT 262 00:09:16,489 --> 00:09:18,424 NIMH OF TWO HUNDRED MILLION 263 00:09:18,491 --> 00:09:20,293 DOLLARS, AND OF COURSE IT'S UP 264 00:09:20,359 --> 00:09:21,694 TO CONGRESS HOW TO EXECUTE THAT 265 00:09:21,761 --> 00:09:22,995 BUDGET, BUT WE LOOK FORWARD TO 266 00:09:23,062 --> 00:09:24,964 LEARNING MORE ABOUT THIS PROCESS 267 00:09:25,031 --> 00:09:29,001 AS THE SUMMER UNFOLDS. 268 00:09:29,068 --> 00:09:30,770 ACCORDINGLY, WE'VE NOW BEEN 269 00:09:30,836 --> 00:09:33,272 THROUGH APPROPRIATIONS HEARINGS 270 00:09:33,339 --> 00:09:38,210 SEASON ON MAY 23RD, 2024. 271 00:09:38,277 --> 00:09:39,845 DR. MONICA BERTAGNOLLI, WHO AWR 272 00:09:39,912 --> 00:09:42,915 GOINGAWR -- WHO YOU'RE GOING TOR 273 00:09:42,982 --> 00:09:46,953 FROM VERY SOON, TESTIFIED BEFORE 274 00:09:47,019 --> 00:09:53,092 THE SENATE APPROPRIATIONS 275 00:09:53,159 --> 00:09:54,660 COMMITTEE, ALL IN SUPPORT OF 276 00:09:54,727 --> 00:09:55,328 THAT PRESIDENTIAL BUDGET REQUEST 277 00:09:55,394 --> 00:09:57,997 THAT I JUST MENTIONED. 278 00:09:58,064 --> 00:10:01,434 S SO WHAT IS THE NIMH BUDGET FOR 279 00:10:01,500 --> 00:10:03,903 2024? 280 00:10:03,970 --> 00:10:05,771 WE'RE REALLY PLEASED -- SORRY, 281 00:10:05,838 --> 00:10:08,274 I'M GOING TO GO HERE FIRST -- 282 00:10:08,341 --> 00:10:11,911 THAT OUR BUDGET OVERALL 283 00:10:11,978 --> 00:10:13,112 NON-BRAIN BUDGET IN LIGHT BLUE, 284 00:10:13,179 --> 00:10:15,514 WENT UP TO APPROXIMATELY 285 00:10:15,581 --> 00:10:18,684 $2.2 BILLION THIS YEAR. 286 00:10:18,751 --> 00:10:21,187 WITH AN EXTRA APPROXIMATELY 287 00:10:21,253 --> 00:10:22,088 $70 MILLION ALLOCATED TO THE 288 00:10:22,154 --> 00:10:23,255 BRAIN INITIATIVE. 289 00:10:23,322 --> 00:10:27,526 THAT REPRESENTS A CONTINUED 290 00:10:27,593 --> 00:10:32,331 INCREASE IN APPROPRIATED DOLLARS 291 00:10:32,398 --> 00:10:35,935 FOR THE NON-BRAIN PORTION OF OUR 292 00:10:36,002 --> 00:10:39,772 BUDGET, AND REPRESENTS A 293 00:10:39,839 --> 00:10:40,973 CONTINUED INCREASE IN BUYING 294 00:10:41,040 --> 00:10:42,308 POWER OVER WHEN I STARTED AT 295 00:10:42,375 --> 00:10:45,478 LEAST IN 2016. 296 00:10:45,544 --> 00:10:46,846 I WILL MENTION SINCE WE'RE ON 297 00:10:46,912 --> 00:10:50,182 THE TOP ECK TOPIC OF THE BRAIN 298 00:10:50,249 --> 00:10:52,818 INITIATIVE, DUE TO THE WAY THE 299 00:10:52,885 --> 00:10:54,053 20TH CENTURY CURES ACT WHICH WAS 300 00:10:54,120 --> 00:10:56,856 PASSED IN 2016 ALLOCATED DOLLARS 301 00:10:56,922 --> 00:10:58,190 OVER THESE ENSUING 10 YEARS, 302 00:10:58,257 --> 00:11:00,226 THERE WAS A DECREASE IN BRAIN 303 00:11:00,292 --> 00:11:02,628 INITIATIVE FUNDING THIS YEAR. 304 00:11:02,695 --> 00:11:04,296 BOTH TO NIMH AND TO THE OTHER 305 00:11:04,363 --> 00:11:05,931 INSTITUTES THAT RECEIVE IT. 306 00:11:05,998 --> 00:11:09,402 AND BRAIN INITIATIVE LEADERSHIP 307 00:11:09,468 --> 00:11:11,704 IS WORKING HARD TO TRY TO 308 00:11:11,771 --> 00:11:14,173 MINIMIZE ANY POTENTIAL NEGATIVE 309 00:11:14,240 --> 00:11:16,409 IMPACT IN THAT DECREASE IN 310 00:11:16,475 --> 00:11:16,976 APPROPRIATIONS. 311 00:11:17,043 --> 00:11:18,277 WHAT ARE WE ABLE TO DO WITH THAT 312 00:11:18,344 --> 00:11:19,045 BUDGET? 313 00:11:19,111 --> 00:11:21,180 WE ANTICIPATE BEING ABLE TO KEEP 314 00:11:21,247 --> 00:11:22,214 SUCCESS RATES STEADY WHILE 315 00:11:22,281 --> 00:11:23,349 INCREASING THE NUMBER OF GRANTS 316 00:11:23,416 --> 00:11:26,819 THAT WE GIVE OUT IN 2024, AND OF 317 00:11:26,886 --> 00:11:27,953 COURSE YOU'VE ALREADY APPROVED 318 00:11:28,020 --> 00:11:29,355 MANY OF THOSE GRANTS FOR FUNDING 319 00:11:29,422 --> 00:11:31,290 IN THE PREVIOUS TWO COUNCIL 320 00:11:31,357 --> 00:11:33,325 ROUNDS, AND WE WILL UNDERGO THE 321 00:11:33,392 --> 00:11:35,795 THIRD COUNCIL ROUND OF APPROVALS 322 00:11:35,861 --> 00:11:36,095 TOMORROW. 323 00:11:36,162 --> 00:11:38,197 WE'RE VERY EXCITED WITH ALL THE 324 00:11:38,264 --> 00:11:39,765 WONDERFUL SCIENCE WE ARE ABLE TO 325 00:11:39,832 --> 00:11:41,167 FUND, AND THE EXPANSION OF THE 326 00:11:41,233 --> 00:11:43,335 PROGRAMS THAT I JUST MENTIONED 327 00:11:43,402 --> 00:11:44,336 FACILITATED BY THE MODEST 328 00:11:44,403 --> 00:11:45,504 INCREASE TO OUR BUDGET THIS 329 00:11:45,571 --> 00:11:52,211 YEAR. 330 00:11:52,278 --> 00:11:54,346 I'LL GIVE YOU SOME UPDATES FROM 331 00:11:54,413 --> 00:11:56,248 HEALTH AND HUMAN SERVICES, THE 332 00:11:56,315 --> 00:11:58,551 DEPARTMENT WE ARE PART OF, THAT 333 00:11:58,617 --> 00:11:59,785 ARE RELEVANT IN PARTICULAR FOR 334 00:11:59,852 --> 00:12:00,186 MENTAL HEALTH. 335 00:12:00,252 --> 00:12:04,457 ON APRIL 23RD, 2024, HHS 336 00:12:04,523 --> 00:12:05,991 RELEASED THE 2024 NATIONAL 337 00:12:06,058 --> 00:12:07,059 STRATEGY FOR SUICIDE PREVENTION. 338 00:12:07,126 --> 00:12:08,928 THIS IS THE FIRST UPDATE TO OUR 339 00:12:08,994 --> 00:12:11,664 NATIONAL STRATEGY FOR SUICIDE 340 00:12:11,730 --> 00:12:17,036 PREVENTION IN ABOUT 10 YEARS. 341 00:12:17,103 --> 00:12:19,105 ITS FOUR STRATEGIC DIRECTIONS 342 00:12:19,171 --> 00:12:20,406 ILLUMINATED ON THE SLIDE ARE 343 00:12:20,473 --> 00:12:21,340 ALIGNED WITH RECOMMENDATIONS 344 00:12:21,407 --> 00:12:22,808 THAT NIMH AND OTHERS HAVE BEEN 345 00:12:22,875 --> 00:12:24,243 MAKING THROUGH ORGANIZATIONS 346 00:12:24,310 --> 00:12:25,211 LIKE THE NATIONAL ACTION 347 00:12:25,277 --> 00:12:28,848 ALLIANCE FOR SUICIDE PREVENTION. 348 00:12:28,914 --> 00:12:31,684 MANY OF NIMHERS WORKED IN 349 00:12:31,750 --> 00:12:33,719 CONCERT WITH MEMBERS OF THE 350 00:12:33,786 --> 00:12:34,386 OFFICE OF SCIENCE AND TECHNOLOGY 351 00:12:34,453 --> 00:12:35,688 POLICY AND THE DOMESTIC POLICY 352 00:12:35,754 --> 00:12:37,923 COUNCIL TO HELP ENSURE THAT THIS 353 00:12:37,990 --> 00:12:40,526 STRATEGY REFLECTS THE LATEST IN 354 00:12:40,593 --> 00:12:43,829 EVIDENCE AND SUICIDE PREVENTION, 355 00:12:43,896 --> 00:12:45,464 AND I'LL JUST SAY AS AN ASIDE, 356 00:12:45,531 --> 00:12:47,099 THIS WAS ONE OF MY PRIORITIES 357 00:12:47,166 --> 00:12:49,935 COMING INTO MY TENURE AT NIMH, 358 00:12:50,002 --> 00:12:54,540 AND WE SUCCEEDED IN DRAMATICALLY 359 00:12:54,607 --> 00:12:56,175 INCREASING THE AMOUNT AND I 360 00:12:56,242 --> 00:12:58,144 THINK ALSO THE QUALITY OF 361 00:12:58,210 --> 00:12:59,478 SUICIDE PREVENTION RESEARCH THAT 362 00:12:59,545 --> 00:13:02,748 NIMH SUPPORTS SUCH THAT WE'RE 363 00:13:02,815 --> 00:13:03,716 FUNDING THREE TIMES AS MUCH 364 00:13:03,782 --> 00:13:06,585 RESEARCH IN THIS AREA AS WE WERE 365 00:13:06,652 --> 00:13:09,188 IN 2016. 366 00:13:09,255 --> 00:13:11,157 THE RESEARCH HAS RESULTED IN 367 00:13:11,223 --> 00:13:12,158 EVIDENCE-BASED APPROACHES THAT 368 00:13:12,224 --> 00:13:13,993 CAN ADDRESS SUICIDE ACROSS 369 00:13:14,059 --> 00:13:16,428 MULTIPLE LEVELS OF SOCIETY AND 370 00:13:16,495 --> 00:13:19,565 ESPECIALLY UNTIL TYPICALLY 371 00:13:19,632 --> 00:13:20,666 UNDERSERVED AND UNDERRESOURCED 372 00:13:20,733 --> 00:13:23,068 AREAS. 373 00:13:23,135 --> 00:13:28,874 THE STRAT STRATEGY IDENTIFIES AL 374 00:13:28,941 --> 00:13:30,309 ACTIONS AGENCIES CAN TAKE AND 375 00:13:30,376 --> 00:13:31,310 NIMH VITAL THERE IN TERMS OF 376 00:13:31,377 --> 00:13:33,145 PRIORITY AREAS FOR OUR FUTURE 377 00:13:33,212 --> 00:13:36,415 RESEARCH ENDEAVORS. 378 00:13:36,482 --> 00:13:41,053 THE NIMH ALSO AS YOU KNOW ON 379 00:13:41,120 --> 00:13:43,556 BEHALF OF HHS RUNS THE 380 00:13:43,622 --> 00:13:44,757 INTERAGENCY AUTISM COORDINATING 381 00:13:44,823 --> 00:13:46,158 COMMITTEE. 382 00:13:46,225 --> 00:13:48,127 WE HAVE AN ACTIVE SPRING WITH A 383 00:13:48,194 --> 00:13:50,095 FULL COMMITTEE MEETING 384 00:13:50,162 --> 00:13:52,164 PUBLICATION OF THE PORTFOLIO 385 00:13:52,231 --> 00:13:53,832 ANALYSIS REPORT AND EVENTS IN 386 00:13:53,899 --> 00:13:55,901 CELEBRATION OF AUTISM ACCEPTANCE 387 00:13:55,968 --> 00:13:57,102 MONTH, AND WE'RE VERY PLEASED 388 00:13:57,169 --> 00:13:59,605 WITH THE WORK THAT IACC HAS BEEN 389 00:13:59,672 --> 00:14:01,707 DOING AS THAT COMMITTEE WILL 390 00:14:01,774 --> 00:14:06,845 SUNSET THIS SUMMER AND THE 391 00:14:06,912 --> 00:14:08,814 CONCLUSION OF THE EXISTING ACT 392 00:14:08,881 --> 00:14:10,115 AND CONGRESS IS HARD AT WORK ON 393 00:14:10,182 --> 00:14:11,850 RENEWAL OF THAT ACT THAT WILL 394 00:14:11,917 --> 00:14:17,690 LIKELY AUTHORIZE A NEW COMING 395 00:14:17,756 --> 00:14:18,090 NEXT YEAR. 396 00:14:18,157 --> 00:14:19,525 A BUNCH TO UPDATE YOU ON FROM 397 00:14:19,592 --> 00:14:20,492 THE NIH. 398 00:14:20,559 --> 00:14:22,361 AND MANY OF THEM WILL AFFECT 399 00:14:22,428 --> 00:14:23,662 MANY OF THE GRANTEES, THOSE OF 400 00:14:23,729 --> 00:14:25,631 YOU IN THE ROOM, AND ALSO THOSE 401 00:14:25,698 --> 00:14:28,100 OF YOU LISTENING MIGHT WANT TO 402 00:14:28,167 --> 00:14:29,468 PAY ATTENTION TO THESE NEXT FEW 403 00:14:29,535 --> 00:14:31,870 SLIDES. 404 00:14:31,937 --> 00:14:33,472 FOR SEVERAL YEARS NOW, THE 405 00:14:33,539 --> 00:14:35,941 CENTER FOR SCIENTIFIC REVIEW AND 406 00:14:36,008 --> 00:14:39,211 OTHERS AT NIH HAVE BEEN WORKING 407 00:14:39,278 --> 00:14:41,614 ON SIMPLIFYING THE REVIEW 408 00:14:41,680 --> 00:14:44,350 FRAMEWORK FOR NIH RESEARCH 409 00:14:44,416 --> 00:14:44,783 PROJECT GRANTS. 410 00:14:44,850 --> 00:14:50,623 IN ORDER TO MAKE SURE THAT THE 411 00:14:50,689 --> 00:14:52,124 REVIEWERS ARE GRADING 412 00:14:52,191 --> 00:14:53,425 APPLICATIONS BASED UPON THE 413 00:14:53,492 --> 00:14:54,994 QUALITY OF RESEARCH AND THE 414 00:14:55,060 --> 00:14:57,363 LIKELIHOOD OF SUCCESS, AS 415 00:14:57,429 --> 00:14:59,431 OPPOSED TO REPUTATIONAL FACTORS 416 00:14:59,498 --> 00:15:04,136 OF INDIVIDUAL INVESTIGATORS OR 417 00:15:04,203 --> 00:15:05,571 INSTITUTIONS, THE PREVIOUS FIVE 418 00:15:05,638 --> 00:15:06,972 REVIEW CRITERIA HAVE BEEN 419 00:15:07,039 --> 00:15:08,741 REORGANIZED INTO THREE FACTORS. 420 00:15:08,807 --> 00:15:11,243 AND THE FACTORS SUBJECT TO THAT 421 00:15:11,310 --> 00:15:15,514 BIAS, INVESTIGATORS OR THE 422 00:15:15,581 --> 00:15:18,250 ENVIRONMENT WILL BE EVALUATED AS 423 00:15:18,317 --> 00:15:20,452 SIMPLY SUFFICIENT OR GAPS 424 00:15:20,519 --> 00:15:22,721 IDENTIFIED AND THOUGH IT WILL BE 425 00:15:22,788 --> 00:15:23,822 CONSIDERED IN THE OVERALL IMPACT 426 00:15:23,889 --> 00:15:25,491 SCORE, THERE WILL NO LONGER BE 427 00:15:25,557 --> 00:15:27,126 INDIVIDUAL SCORES IN THE REVIEW 428 00:15:27,192 --> 00:15:28,327 PROCESS ASSIGNED TO INVESTIGATOR 429 00:15:28,394 --> 00:15:30,829 AND ENVIRONMENT. 430 00:15:30,896 --> 00:15:32,931 ADDITIONAL REVIEW CRITERIA 431 00:15:32,998 --> 00:15:34,099 INCLUDING INCLUSION STUDY 432 00:15:34,166 --> 00:15:37,069 TIMELINES, ET CETERA, RELATED TO 433 00:15:37,136 --> 00:15:39,471 HUMAN SUBJECTS, WILL BE 434 00:15:39,538 --> 00:15:42,207 EVALUATED WITHIN THE FACTOR TWO 435 00:15:42,274 --> 00:15:43,642 WHICH INVOLVES THE QUALITY AND 436 00:15:43,709 --> 00:15:45,678 RIGOR OF THE SCIENCE TO ENSURE 437 00:15:45,744 --> 00:15:47,346 THAT THOSE FACTORS ARE TAKEN 438 00:15:47,413 --> 00:15:48,547 INTO CONSIDERATION WHEN THE 439 00:15:48,614 --> 00:15:50,416 APPLICATION IS SCORED. 440 00:15:50,482 --> 00:15:52,184 MOST OTHER ADDITIONAL REVIEW 441 00:15:52,251 --> 00:15:54,119 CONSIDERATIONS THAT REALLY DON'T 442 00:15:54,186 --> 00:15:55,354 HAVE MUCH TO DO WITH THE QUALITY 443 00:15:55,421 --> 00:15:57,523 OF THE SCIENCE BUT RATHER WITH 444 00:15:57,589 --> 00:15:59,725 OPERATIONAL DETAILS HAVE BEEN 445 00:15:59,792 --> 00:16:01,593 SHIFTED IN RESPONSIBILITY FROM 446 00:16:01,660 --> 00:16:02,995 THE REVIEWERS TO NIH STAFF WHO 447 00:16:03,062 --> 00:16:04,196 CAN JUST MAKE SURE THAT THOSE 448 00:16:04,263 --> 00:16:07,800 REQUIREMENTS ARE MET. 449 00:16:07,866 --> 00:16:09,234 THESE CHANGES WE HOPE WILL 450 00:16:09,301 --> 00:16:11,103 BETTER FACILITATE THE 451 00:16:11,170 --> 00:16:12,071 OVERARCHING GOAL PEER REVIEW, 452 00:16:12,137 --> 00:16:13,806 WHICH IS TO IDENTIFY THE 453 00:16:13,872 --> 00:16:15,040 STRONGEST AND HIGHEST IMPACT 454 00:16:15,107 --> 00:16:15,507 RESEARCH. 455 00:16:15,574 --> 00:16:16,875 THERE'S A PUBLIC WEBSITE THAT 456 00:16:16,942 --> 00:16:18,944 DESCRIBES THESE REVIEW 457 00:16:19,011 --> 00:16:19,511 FRAMEWORKS. 458 00:16:19,578 --> 00:16:20,913 IT'S GOING TO BE A WORK IN 459 00:16:20,979 --> 00:16:22,681 PROGRESS, OF COURSE, AS WE TRAIN 460 00:16:22,748 --> 00:16:24,416 REVIEWERS, AND WE ENSURE 461 00:16:24,483 --> 00:16:26,952 APPLICANT KNS KNOW WHAT TO EXPET 462 00:16:27,019 --> 00:16:28,687 THROUGH THE REVIEW PROCESS, AND 463 00:16:28,754 --> 00:16:30,022 WE WELCOME FEEDBACK ALONG THE 464 00:16:30,089 --> 00:16:37,763 WAY. 465 00:16:37,830 --> 00:16:39,098 NEXT I WANT TO MENTION AN 466 00:16:39,164 --> 00:16:41,266 EXCITING NEW PROGRAM THAT IS A 467 00:16:41,333 --> 00:16:42,701 PRIORITY OF THE NEW NIH 468 00:16:42,768 --> 00:16:45,738 DIRECTOR, DR. BERTAGNOLLI, IN 469 00:16:45,804 --> 00:16:47,840 RECOGNITION THAT MANY HEALTH 470 00:16:47,906 --> 00:16:48,974 INDICES OF THE U.S. POPULATION 471 00:16:49,041 --> 00:16:50,476 ARE IN DECLINE AND THAT THAT 472 00:16:50,542 --> 00:16:52,311 DECLINE STEEPEST AMONGST THE 473 00:16:52,378 --> 00:16:57,116 UNDERSERRSESERVED AND 474 00:16:57,182 --> 00:16:58,884 UNDERREPRESENTED. 475 00:16:58,951 --> 00:17:01,620 DR. BERTAGNOLLI HAS INSPIRED THE 476 00:17:01,687 --> 00:17:03,922 NIH TO WORK ON DEVELOPING A 477 00:17:03,989 --> 00:17:06,458 CLINICAL RESEARCH NETWORK 478 00:17:06,525 --> 00:17:07,760 EMBEDDED WITHIN PRIMARY CARE 479 00:17:07,826 --> 00:17:11,463 SETTINGS TO ENSURE, ONE, AN 480 00:17:11,530 --> 00:17:14,633 ACTIVE DISEASE-AGNOSTIC CLINICAL 481 00:17:14,700 --> 00:17:16,068 RESEARCH NETWORK THAT CAN 482 00:17:16,135 --> 00:17:17,102 FACILITATE CLINICAL RESEARCH 483 00:17:17,169 --> 00:17:18,771 RELEVANT TO ALL THE INSTITUTES 484 00:17:18,837 --> 00:17:19,772 AND CENTERS, AND TWO, TO MAKE 485 00:17:19,838 --> 00:17:21,206 SURE THAT THAT INNOVATIVE 486 00:17:21,273 --> 00:17:27,346 RESEARCH IS INTEGRATED WITH AN D 487 00:17:27,413 --> 00:17:28,847 ENGAGED IN COMMUNITIES WITH 488 00:17:28,914 --> 00:17:29,515 UNDERREPRESENTED CLINICAL 489 00:17:29,581 --> 00:17:29,982 RESEARCH. 490 00:17:30,048 --> 00:17:31,517 WE'VE BEEN GATHERING FEEDBACK 491 00:17:31,583 --> 00:17:32,885 FROM THE COMMUNITY ON IDEAS THIS 492 00:17:32,951 --> 00:17:34,319 SPRING WITH A PLAN TO LAUNCH 493 00:17:34,386 --> 00:17:36,822 THIS NETWORK WITH SOME EXISTING 494 00:17:36,889 --> 00:17:39,458 AND SOME NEW CAPABILITIES 495 00:17:39,525 --> 00:17:42,094 STARTING IN THE FALL OF 2024 496 00:17:42,161 --> 00:17:44,830 WITH FUTURE EXPANSIONS AS BUDGET 497 00:17:44,897 --> 00:17:48,667 PERMITS. 498 00:17:48,734 --> 00:17:50,002 WE'RE REALLY EXCITED ABOUT THE 499 00:17:50,068 --> 00:17:52,604 POTENTIAL FOR THIS APPROACH. 500 00:17:52,671 --> 00:17:54,006 WHILE NIMH HAS FOR LOTS OF 501 00:17:54,072 --> 00:17:58,811 DIFFERENT REASONS BEEN -- NOT 502 00:17:58,877 --> 00:18:01,246 BEEN PARTICULARLY INTERESTED IN 503 00:18:01,313 --> 00:18:02,881 FUNDING CLINICAL RESEARCH 504 00:18:02,948 --> 00:18:04,616 NETWORKS, IT'S OFTEN BECAUSE WE 505 00:18:04,683 --> 00:18:05,818 FOUND THOSE NETWORKS IN THE PAST 506 00:18:05,884 --> 00:18:08,120 TO BE UNDERUTILIZED. 507 00:18:08,187 --> 00:18:11,190 AND THIS WILL ALLOW US TO HAVE 508 00:18:11,256 --> 00:18:13,826 ACCESS TO CLINICAL RESEARCH 509 00:18:13,892 --> 00:18:15,561 NETWORKS WITH ESTABLISHED 510 00:18:15,627 --> 00:18:16,328 ABILITIES TO REACH INTO 511 00:18:16,395 --> 00:18:18,397 COMMUNITIES THAT ARE OTHERWISE 512 00:18:18,464 --> 00:18:19,031 UNDERREPRESENTED IN SCIENCE TO 513 00:18:19,097 --> 00:18:21,366 TAKE ADVANTAGE OF THOSE NETWORKS 514 00:18:21,433 --> 00:18:23,435 BUT NOT HAVE TO FUND THEM OR 515 00:18:23,502 --> 00:18:25,070 THEIR INFRASTRUCTURE ON OUR OWN. 516 00:18:25,137 --> 00:18:27,139 SO WE LOOK AT THIS AS AN 517 00:18:27,206 --> 00:18:28,574 EXCITING DEVELOPMENT THAT WE 518 00:18:28,640 --> 00:18:30,509 HOPE WE'LL SUCCEED OVER THE NEXT 519 00:18:30,576 --> 00:18:37,549 SEVERAL YEARS. 520 00:18:37,616 --> 00:18:39,084 IN ADDITION OF COURSE TO OUR NEW 521 00:18:39,151 --> 00:18:40,152 DIRECTOR WHO CAME ON BOARD LAST 522 00:18:40,219 --> 00:18:43,889 FALL AND WHO WILL SPEAK TO US 523 00:18:43,956 --> 00:18:46,291 SOON, -- I'M TRYING TO GET THIS 524 00:18:46,358 --> 00:18:47,192 TO ADVANCE AND IT'S NOT. 525 00:18:47,259 --> 00:18:47,826 THERE YOU GO. 526 00:18:47,893 --> 00:18:48,260 OKAY. 527 00:18:48,327 --> 00:18:49,561 THERE ARE SOME OTHER LEADERSHIP 528 00:18:49,628 --> 00:18:51,463 CHANGES TO MAKE YOU AWARE. 529 00:18:51,530 --> 00:18:55,501 ON MAY 6, 2024, DR. KATHLEEN 530 00:18:55,567 --> 00:18:56,702 NEUZIL BEGAN HER ROLE AS 531 00:18:56,768 --> 00:18:58,437 DIRECTOR OF THE FOGARTY 532 00:18:58,504 --> 00:19:00,172 INTERNATIONAL CENTER, SUCCEEDING 533 00:19:00,239 --> 00:19:02,641 PETER KILMARX, WHO HAD SERVED AS 534 00:19:02,708 --> 00:19:03,742 ACTING DIRECTOR SINCE JANUARY OF 535 00:19:03,809 --> 00:19:05,410 2023. 536 00:19:05,477 --> 00:19:08,280 WE'RE VERY EXCITED TO WELCOME 537 00:19:08,347 --> 00:19:09,481 DR. NEUZIL TO OUR FAMILY OF 538 00:19:09,548 --> 00:19:10,449 INSTITUTE AND CENTER DIRECTORS, 539 00:19:10,516 --> 00:19:13,986 AND ALSO GREATLY APPRECIATED DR. 540 00:19:14,052 --> 00:19:16,054 FOR THOSE OF YOU WHO DON'T KNOW, 541 00:19:16,121 --> 00:19:17,356 FOGARTY INTERNATIONAL CENTER 542 00:19:17,422 --> 00:19:19,324 OVERSEES AND FACILITATES HEALTH 543 00:19:19,391 --> 00:19:22,861 RESEARCH ON THE GLOBAL SCENE, 544 00:19:22,928 --> 00:19:27,432 PRARLY IN LOWER AND MID ILL MIDE 545 00:19:27,499 --> 00:19:29,401 INCOME COUNTRIES AND ALSO 546 00:19:29,468 --> 00:19:30,469 DIPLOMATIC ARRANGEMENTS AND 547 00:19:30,536 --> 00:19:31,136 RELATIONSHIPS WITH HEALTH 548 00:19:31,203 --> 00:19:32,104 ORGANIZATIONS THROUGHOUT THE 549 00:19:32,170 --> 00:19:32,304 GLOBE. 550 00:19:32,371 --> 00:19:33,338 THEY'VE BEEN A TREMENDOUS 551 00:19:33,405 --> 00:19:36,174 PARTNER FOR US OVER THE LAST 15 552 00:19:36,241 --> 00:19:38,744 YEARS OR SO, AS WE HAVE EXPANDED 553 00:19:38,810 --> 00:19:42,481 OUR EFFORTS IN GLOBAL MENTAL 554 00:19:42,548 --> 00:19:44,583 HEALTH, AND WE LOOK FORWARD TO 555 00:19:44,650 --> 00:19:46,451 CONTINUED COLLABORATION UNDER 556 00:19:46,518 --> 00:19:48,754 DR. NEUZIL. 557 00:19:48,820 --> 00:19:53,458 ANOTHER SENIOR LEADER AT NIH IS 558 00:19:53,525 --> 00:19:54,693 DR. SHAWN MOONEY, NAMED DIRECTOR 559 00:19:54,760 --> 00:19:56,662 OF THE NIH'S CENTER FOR 560 00:19:56,728 --> 00:19:58,931 INFORMATION TECHNOLOGY, 561 00:19:58,997 --> 00:20:05,804 SUCCEEDING DR. D'SOUZA, ACTING 562 00:20:05,871 --> 00:20:06,638 DIRECTOR SINCE SEPTEMBER OF 563 00:20:06,705 --> 00:20:07,105 2022. 564 00:20:07,172 --> 00:20:08,340 AND THAT'S IT FOR LEADERSHIP 565 00:20:08,407 --> 00:20:10,409 CHANGES. 566 00:20:10,475 --> 00:20:11,843 I DID MENTION, OF COURSE, THE 567 00:20:11,910 --> 00:20:15,213 BRAIN INITIATIVE BEFORE, AND 568 00:20:15,280 --> 00:20:16,815 THEY HAVE AN ANNUAL CONFERENCE 569 00:20:16,882 --> 00:20:17,950 THAT'S GOING TO TAKE PLACE IN 570 00:20:18,016 --> 00:20:19,718 JUST A FEW WEEKS. 571 00:20:19,785 --> 00:20:22,421 HERE IN ROCKVILLE, AS WELL AS 572 00:20:22,487 --> 00:20:23,655 VIRTUALLY, AND I ENCOURAGE THOSE 573 00:20:23,722 --> 00:20:25,490 OF YOU HAVE WITH INTEREST IN 574 00:20:25,557 --> 00:20:26,692 THIS AREA TO REGISTER. 575 00:20:26,758 --> 00:20:29,561 IT'S FREE, AND TO ATTEND EITHER 576 00:20:29,628 --> 00:20:34,766 IN PERSON OR VIRTUALLY. 577 00:20:34,833 --> 00:20:36,101 ANOTHER CONFERENCE ON ANOTHER 578 00:20:36,168 --> 00:20:38,070 TRANS-NIH INITIATIVE THAT NIMH 579 00:20:38,136 --> 00:20:41,039 IS ACTIVE IN IS THE CLIMATE AND 580 00:20:41,106 --> 00:20:42,007 CHANGE HEALTH INITIATIVE WHICH 581 00:20:42,074 --> 00:20:44,543 IS SPONSORING THEIR FIRST ANNUAL 582 00:20:44,610 --> 00:20:45,844 CAFE, CLIMATE AND HEALTH 583 00:20:45,911 --> 00:20:48,146 CONFERENCE, LED JOINTLY BY THE 584 00:20:48,213 --> 00:20:49,681 GRANTEES OF THE CLIMATE CHANGE 585 00:20:49,748 --> 00:20:52,851 AND HEALTH INITIATIVE BOSTON 586 00:20:52,918 --> 00:20:53,418 UNIVERSITY SCHOOL OF PUBLIC 587 00:20:53,485 --> 00:20:55,220 HEALTH AND THE HARVARD CHAN 588 00:20:55,287 --> 00:20:56,888 SCHOOL OF PUBLIC HEALTH. 589 00:20:56,955 --> 00:20:58,523 THIS CLIMATE CHANGE AND HEALTH 590 00:20:58,590 --> 00:21:00,292 INITIATIVE WHICH IS LED BY A 591 00:21:00,359 --> 00:21:02,094 GROUP OF INSTITUTE DIRECTORS 592 00:21:02,160 --> 00:21:05,530 INCLUDING DR. RICK WOYCHIK, IS 593 00:21:05,597 --> 00:21:07,065 HEAVILY INVESTING IN TRYING TO 594 00:21:07,132 --> 00:21:08,166 UNDERSTAND AND MITIGATE THE 595 00:21:08,233 --> 00:21:09,601 IMPACTS OF CLIMATE CHANGE ON 596 00:21:09,668 --> 00:21:11,136 HEALTH INCLUDING MENTAL HEALTH, 597 00:21:11,203 --> 00:21:13,605 AND IT'S AN EXCITING INITIATIVE 598 00:21:13,672 --> 00:21:15,574 WHICH NIMH -- SEVERAL NIMH 599 00:21:15,641 --> 00:21:18,777 STAFFERS PARTICIPATE IN. 600 00:21:18,844 --> 00:21:22,481 LET'S FOCUS DOWN THEN NOW ON 601 00:21:22,547 --> 00:21:27,185 NIMH. 602 00:21:27,252 --> 00:21:28,487 YOU KNOW ALREADY BECAUSE IT WAS 603 00:21:28,553 --> 00:21:31,690 ANNOUNCED IN FEBRUARY, ON 604 00:21:31,757 --> 00:21:33,525 FEBRUARY 29TH, I ANNOUNCED MY 605 00:21:33,592 --> 00:21:36,061 DECISION, MY PAINFUL DECISION TO 606 00:21:36,128 --> 00:21:38,563 STEP DOWN AS NIMH DIRECTOR 607 00:21:38,630 --> 00:21:40,966 EFFECTIVE JUNE 14TH, 2024, WHICH 608 00:21:41,033 --> 00:21:44,469 IS TWO WEEKS FROM TOMORROW. 609 00:21:44,536 --> 00:21:46,004 WHEN I ANNOUNCED IT IN FEBRUARY, 610 00:21:46,071 --> 00:21:47,439 IT SEEMED SO FAR AWAY, NOW IT 611 00:21:47,506 --> 00:21:48,607 DOESN'T SEEM SO FAR AWAY 612 00:21:48,674 --> 00:21:49,074 ANYMORE. 613 00:21:49,141 --> 00:21:52,444 I'M PLEASED TO ANNOUNCE THAT 614 00:21:52,511 --> 00:22:00,652 SHELLEY ASHESHELLEY WILL SERVE G 615 00:22:00,719 --> 00:22:01,753 NIMH DIRECTOR. 616 00:22:01,820 --> 00:22:03,221 I'M ALSO PLEASED TO ANOWS THAT 617 00:22:03,288 --> 00:22:05,891 NIH IS ABOUT TO LAUNCH -- THEY 618 00:22:05,957 --> 00:22:07,559 GOT THE SEARCH COMMITTEE 619 00:22:07,626 --> 00:22:08,527 TOGETHER ALREADY -- A NATIONAL 620 00:22:08,593 --> 00:22:10,162 SEARCH FOR A NEW DIRECTOR WHICH 621 00:22:10,228 --> 00:22:13,999 THEY HOPE TO PROCEED 622 00:22:14,066 --> 00:22:14,332 EXPEDITIOUSLY. 623 00:22:14,399 --> 00:22:16,401 LET ME JUST SAY FROM TWO 624 00:22:16,468 --> 00:22:18,070 PERSONAL NOTES, ONE, THIS IS 625 00:22:18,136 --> 00:22:21,873 REALLY BITTERSWEET FOR ME, I'M 626 00:22:21,940 --> 00:22:22,874 EXCITED ABOUT WHAT COMES NEXT 627 00:22:22,941 --> 00:22:28,480 BUT I'M ALSO COGNIZANT OF THE 628 00:22:28,547 --> 00:22:29,648 FACT THAT THIS IS THE BEST JOB 629 00:22:29,715 --> 00:22:31,183 IN THIS FIELD, PERIOD, END OF 630 00:22:31,249 --> 00:22:31,516 STORY. 631 00:22:31,583 --> 00:22:33,151 I'VE LOVED MY TIME HERE, I'VE 632 00:22:33,218 --> 00:22:35,020 LOVED WORKING WITH THE NIMH 633 00:22:35,087 --> 00:22:37,322 STAFF, MY FELLOW NIH DIRECTORS, 634 00:22:37,389 --> 00:22:38,724 AND ALL OF YOU AROUND THE TABLE 635 00:22:38,790 --> 00:22:40,258 AND OTHERS WHO HAVE SERVED ON 636 00:22:40,325 --> 00:22:41,460 THE COUNCIL IN THE PAST, AND IT 637 00:22:41,526 --> 00:22:44,062 WILL BE DIFFICULT IF NOT 638 00:22:44,129 --> 00:22:45,197 IMPOSSIBLE TO REPLICATE THE JOY 639 00:22:45,263 --> 00:22:46,965 THAT I'VE EXPERIENCED OVER THESE 640 00:22:47,032 --> 00:22:48,266 PAST EIGHT YEARS. 641 00:22:48,333 --> 00:22:49,868 THE SECOND THING I WANT TO SAY 642 00:22:49,935 --> 00:22:52,738 IS I'M REALLY PLEASED THAT 643 00:22:52,804 --> 00:22:56,441 SHELLI HAS AGREED AND WILL BE 644 00:22:56,508 --> 00:22:58,043 STEWARDING THIS ORGANIZATION 645 00:22:58,110 --> 00:22:59,411 OVER THE COMING MONTHS AND 646 00:22:59,478 --> 00:23:02,914 HOPEFULLY NOT YEARS. 647 00:23:02,981 --> 00:23:04,750 YOU ALL KNOW SHELLI. 648 00:23:04,816 --> 00:23:07,519 SHE IS AN OUTSTANDING LEADER, A 649 00:23:07,586 --> 00:23:08,720 BRILLIANT SCIENTIST, AND REALLY 650 00:23:08,787 --> 00:23:10,222 COMMITTED TO THE NIMH MISSION 651 00:23:10,288 --> 00:23:13,625 AND I KNOW THAT SHE WILL DO AN 652 00:23:13,692 --> 00:23:15,827 OUTSTANDING JOB AS THE FIRST 653 00:23:15,894 --> 00:23:17,129 FEMALE DIRECTOR OF NIMH. 654 00:23:17,195 --> 00:23:18,330 WE'RE VERY PLEASED THAT SHE IS 655 00:23:18,396 --> 00:23:18,764 DOING THIS. 656 00:23:18,830 --> 00:23:29,141 THANK YOU, SHELLI. 657 00:23:30,976 --> 00:23:31,710 THERE'S ALSO HAPPINESS THIS 658 00:23:31,777 --> 00:23:31,943 YEAR. 659 00:23:32,010 --> 00:23:33,678 THIS YEAR IS OUR 75TH 660 00:23:33,745 --> 00:23:34,112 ANNIVERSARY. 661 00:23:34,179 --> 00:23:35,413 MANY OF YOU HAVE ATTENDED ONE OR 662 00:23:35,480 --> 00:23:37,149 MORE EVENTS THAT MARK THIS. 663 00:23:37,215 --> 00:23:38,250 I MENTIONED, OF COURSE, THAT WE 664 00:23:38,316 --> 00:23:39,684 HAD AN EVENT ON THE HILL 665 00:23:39,751 --> 00:23:42,654 CELEBRATING IT WITH HILL 666 00:23:42,721 --> 00:23:44,389 STAFFERS AND OTHER SUPPORTERS OF 667 00:23:44,456 --> 00:23:46,158 NIMH HOSTED BY THE FRIENDS OF 668 00:23:46,224 --> 00:23:47,793 NIMH. 669 00:23:47,859 --> 00:23:50,829 WE HAVE -- WE HAD OUR SECOND 670 00:23:50,896 --> 00:23:52,931 SYMPOSIUM ENTITLED AMPLIFYING 671 00:23:52,998 --> 00:23:54,232 VOICES AND BUILDING BRIDGES 672 00:23:54,299 --> 00:23:56,768 TOWARD A MORE INCLUSIVE FUTURE 673 00:23:56,835 --> 00:23:57,302 ON MARCH 18TH. 674 00:23:57,369 --> 00:23:59,604 IT WAS A PROVOCATIVE DAY IN 675 00:23:59,671 --> 00:24:02,040 DOWNTOWN D.C. AT THE NATIONAL 676 00:24:02,107 --> 00:24:02,340 ARCHIVES. 677 00:24:02,407 --> 00:24:06,311 WE WILL HOST OUR NEXT EVENT ALSO 678 00:24:06,378 --> 00:24:08,880 I BELIEVE AT THE ARCHIVES ON 679 00:24:08,947 --> 00:24:09,981 SEPTEMBER 20TH, 2024 IN 680 00:24:10,048 --> 00:24:11,183 WASHINGTON, D.C., AND I HAD BEEN 681 00:24:11,249 --> 00:24:12,517 GIVEN SPECIAL DISPENSATION TO BE 682 00:24:12,584 --> 00:24:14,152 ALLOWED TO ATTEND THIS EVENT, 683 00:24:14,219 --> 00:24:15,987 I'M VERY MUCH LOOKING FORWARD TO 684 00:24:16,054 --> 00:24:16,822 IT. 685 00:24:16,888 --> 00:24:18,223 YOU CAN ALSO -- THERE'S A LOT 686 00:24:18,290 --> 00:24:19,391 MORE THAN JUST THESE EVENTS. 687 00:24:19,457 --> 00:24:21,693 THERE ARE PODCASTS, STORIES AND 688 00:24:21,760 --> 00:24:25,130 DIGITAL RESOURCES THAT HIGHLIGHT 689 00:24:25,197 --> 00:24:26,498 NIMH'S IMPACT ON MENTAL HEALTH 690 00:24:26,565 --> 00:24:28,800 RESEARCH AVAILABLE THROUGH OUR 691 00:24:28,867 --> 00:24:36,007 WEBSITE, NIMH.NIH.GOV/75YEARS. 692 00:24:36,074 --> 00:24:37,342 ENCOURAGE YOU TO VISIT THAT FOR 693 00:24:37,409 --> 00:24:38,543 THOSE RESOURCES AND SHARE THEM 694 00:24:38,610 --> 00:24:40,612 WITH YOUR FRIENDS, FAMILY, 695 00:24:40,679 --> 00:24:41,713 NEIGHBORS AND WHOEVER ELSE IS 696 00:24:41,780 --> 00:24:47,519 INTERESTED. 697 00:24:47,586 --> 00:24:49,521 WE ALSO HAVE OUR ANNUAL UPDATE 698 00:24:49,588 --> 00:24:51,122 TO THE NIMH STRATEGIC PLAN FOR 699 00:24:51,189 --> 00:24:51,389 RESEARCH. 700 00:24:51,456 --> 00:24:53,625 MUCH OF THIS UPDATE 701 00:24:53,692 --> 00:24:56,027 RE-EMPHASIZES PRIORITY AREAS AND 702 00:24:56,094 --> 00:24:58,230 CLARIFIES OUR DESCRIPTION TO 703 00:24:58,296 --> 00:24:59,631 PRIORITIES, FOR EXAMPLE, WITHIN 704 00:24:59,698 --> 00:25:00,565 A GLOBAL MENTAL HEALTH RESEARCH 705 00:25:00,632 --> 00:25:01,733 PROGRAM THAT HAVE BEEN UPDATED 706 00:25:01,800 --> 00:25:07,739 BY OUR CENTER DIRECTOR, AND HIS 707 00:25:07,806 --> 00:25:08,974 STAFF AND THE GLOBAL MENTAL 708 00:25:09,040 --> 00:25:09,474 HEALTH TEAM. 709 00:25:09,541 --> 00:25:11,142 ALSO SOME CHANGES TO EMPHASIZE 710 00:25:11,209 --> 00:25:13,345 CURRENT APPROACHES IN REACHING 711 00:25:13,411 --> 00:25:14,746 THE NEEDS OF INDIVIDUALS FROM 712 00:25:14,813 --> 00:25:19,017 UNDERSERVED POPULATIONS AND DATA 713 00:25:19,084 --> 00:25:19,651 AND DIGITAL HEALTH. 714 00:25:19,718 --> 00:25:21,620 WE ALSO PUBLISH ANNUALLY A 715 00:25:21,686 --> 00:25:23,054 STRATEGIC PLAN PROGRESS REPORT 716 00:25:23,121 --> 00:25:25,790 WHICH HAS JUST COME OUT. 717 00:25:25,857 --> 00:25:28,960 IT SPOTLIGHTS THE 75TH 718 00:25:29,027 --> 00:25:31,029 ANNIVERSARY YEAR EVENTS, SEVERAL 719 00:25:31,096 --> 00:25:32,230 DIFFERENT SCIENCE HIGHLIGHTS AND 720 00:25:32,297 --> 00:25:34,532 SOME STATISTICS FROM LAST YEAR, 721 00:25:34,599 --> 00:25:35,634 LAST FISCAL YEAR 2023 IN TERMS 722 00:25:35,700 --> 00:25:36,935 OF FUNDING AND PROJECTS, ET 723 00:25:37,002 --> 00:25:40,438 CETERA. 724 00:25:40,505 --> 00:25:41,973 THIS IS A TWO-PAGE DOCUMENT. 725 00:25:42,040 --> 00:25:43,275 YOU CAN EASILY PRINT AND HAND 726 00:25:43,341 --> 00:25:43,708 OUT. 727 00:25:43,775 --> 00:25:45,477 I ENCOURAGE YOU TO SHARE THAT AS 728 00:25:45,543 --> 00:25:49,848 WELL. 729 00:25:49,915 --> 00:25:52,284 IT'S ABOUT TIME WE DO A THOROUGH 730 00:25:52,350 --> 00:25:53,685 REWRITE OF OUR STRATEGIC PLAN. 731 00:25:53,752 --> 00:25:55,086 AS WE THINK ABOUT DOING THAT, 732 00:25:55,153 --> 00:25:57,055 LOOKING FORWARD TO 2025 AND 733 00:25:57,122 --> 00:25:58,590 2026, WHICH WILL BE THE FIFTH 734 00:25:58,657 --> 00:26:00,792 AND SIXTH YEAR SINCE WE TURNED 735 00:26:00,859 --> 00:26:03,862 THE PLAN INTO A LIVE DOCUMENT 736 00:26:03,929 --> 00:26:05,830 LISTED ON THE WEB. 737 00:26:05,897 --> 00:26:08,433 WE ARE PUTTING OUT A REQUEST FOR 738 00:26:08,500 --> 00:26:10,402 INFORMATION ON THE USABILITY, 739 00:26:10,468 --> 00:26:11,603 EFFECTIVENESS AND IMPACT OF THE 740 00:26:11,670 --> 00:26:15,006 CURRENT STRATEGIC PLAN SO THAT 741 00:26:15,073 --> 00:26:17,008 WE CAN LOOK TO DECIDE HOW TO 742 00:26:17,075 --> 00:26:19,711 MOVE FORWARD WITH THE EXTENSIVE 743 00:26:19,778 --> 00:26:21,846 REVISIONS THAT WE PLAN IN 2025 744 00:26:21,913 --> 00:26:23,548 OR 2026. 745 00:26:23,615 --> 00:26:25,850 THIS RFI IS LIVE ON THE STREET. 746 00:26:25,917 --> 00:26:28,687 PLEASE SUBMIT FEEDBACK BY 747 00:26:28,753 --> 00:26:29,988 JULY 24TH, AND IF YOU HAVE ANY 748 00:26:30,055 --> 00:26:31,089 QUESTIONS, PLEASE REACH OUT TO 749 00:26:31,156 --> 00:26:41,766 OUR STAFF AT NIMHSTRISTR 750 00:26:42,167 --> 00:26:42,834 NIMHSTRATPLAN@MAIL.NIH.GOV. 751 00:26:42,901 --> 00:26:44,235 WE HAVE TWO ADDITIONAL RFIs 752 00:26:44,302 --> 00:26:45,870 THAT I WANT TO MAKE CLEAR TO 753 00:26:45,937 --> 00:26:46,304 YOU. 754 00:26:46,371 --> 00:26:49,240 ON APRIL 8TH WE RELEASED AN RFI 755 00:26:49,307 --> 00:26:50,241 ON RESEARCH GAPS ON THE IMPACT 756 00:26:50,308 --> 00:26:50,675 OF RACISM. 757 00:26:50,742 --> 00:26:54,713 THIS WAS AUTHORED BY STAFF IN 758 00:26:54,779 --> 00:26:56,481 OUR OFFICE OF DISPARITIES 759 00:26:56,548 --> 00:26:57,682 RESEARCH AND WORKFORCE 760 00:26:57,749 --> 00:26:59,184 DIVERSITY. 761 00:26:59,250 --> 00:27:01,653 AS WELL AS OUR DISPARITIES -- 762 00:27:01,720 --> 00:27:02,387 MENTAL HEALTH DISPARITIES 763 00:27:02,454 --> 00:27:04,556 RESEARCH TEAM. 764 00:27:04,622 --> 00:27:06,324 WE'RE ASKING FOR INPUT ON 765 00:27:06,391 --> 00:27:07,392 RESEARCH APPROACHES THAT COULD 766 00:27:07,459 --> 00:27:08,927 ADDRESS THE IMPACT OF STRUCTURAL 767 00:27:08,994 --> 00:27:10,795 RACISM ON BRAIN COGNITIVE AND 768 00:27:10,862 --> 00:27:13,531 BEHAVIORAL FUNCTION. 769 00:27:13,598 --> 00:27:18,136 AND THE ROLE OF STRUCTURAL AND 770 00:27:18,203 --> 00:27:20,038 SYSTEMIC RACISM ON BRAIN AND 771 00:27:20,105 --> 00:27:23,708 BEHAVIORAL HEALTH RESEARCH. 772 00:27:23,775 --> 00:27:26,177 AND ON APRIL 5TH WE RELEASED AN 773 00:27:26,244 --> 00:27:27,912 RFI ON RESEARCH GAPS IN MENTAL 774 00:27:27,979 --> 00:27:29,280 HEALTH SERVICES RESEARCH, 775 00:27:29,347 --> 00:27:30,715 INVITING INPUT ON STRATEGIES TO 776 00:27:30,782 --> 00:27:33,051 ADVANCE THE RELEVANCE AND IMPACT 777 00:27:33,118 --> 00:27:33,752 OF MENTAL HEALTH SERVICES 778 00:27:33,818 --> 00:27:34,953 RESEARCH AND OUTCOMES THAT ARE 779 00:27:35,020 --> 00:27:37,355 MOST IMPORTANT AS WE TRY TO 780 00:27:37,422 --> 00:27:38,690 DEMONSTRATE OR IMPROVE THE 781 00:27:38,757 --> 00:27:39,691 QUALITY OF MENTAL HEALTHCARE, 782 00:27:39,758 --> 00:27:41,226 AND THOSE RESPONSES ARE 783 00:27:41,292 --> 00:27:43,928 REQUESTED BY SEPTEMBER 1ST. 784 00:27:43,995 --> 00:27:45,030 FINALLY, AND YOU ALL ON THE 785 00:27:45,096 --> 00:27:46,898 COUNCIL ARE WELL ACQUAINTED WITH 786 00:27:46,965 --> 00:27:48,099 THIS, AS THIS HAS BEEN AN 787 00:27:48,166 --> 00:27:49,300 ONGOING ENDEAVOR FOR THE LAST 788 00:27:49,367 --> 00:27:52,037 SEVERAL YEARS AND WE DISCUSSED 789 00:27:52,103 --> 00:27:53,371 AND GOT APPROVAL FOR THESE 790 00:27:53,438 --> 00:27:54,539 CHANGES MOST RECENTLY AT THE 791 00:27:54,606 --> 00:27:57,976 LAST COUNCIL MEETING, WE PUBL 792 00:27:58,043 --> 00:27:59,277 PUBLISHED A REVISION, A REVISED 793 00:27:59,344 --> 00:28:01,446 NOTICE CLARIFYING NIMH'S FUNDING 794 00:28:01,513 --> 00:28:03,415 PRIORITIES FOR AWARDS SUPPORTING 795 00:28:03,481 --> 00:28:04,282 EXCEPTIONALLY WELL-FUNDED 796 00:28:04,349 --> 00:28:05,417 INVESTIGATORS. 797 00:28:05,483 --> 00:28:08,887 THE NIMH NOW DEFINES 798 00:28:08,953 --> 00:28:10,288 APPLICATIONS WITH WELL-FUNDED 799 00:28:10,355 --> 00:28:11,823 INVESTIGATORS -- SORRY -- 800 00:28:11,890 --> 00:28:13,158 DEFINES WELL-FUNDED 801 00:28:13,224 --> 00:28:14,459 INVESTIGATORS AS THOSE WHO 802 00:28:14,526 --> 00:28:16,528 RECEIVE NIH FUNDING SUPPORT OF 803 00:28:16,594 --> 00:28:18,730 AT LEAST $2 MILLION IN TOTAL 804 00:28:18,797 --> 00:28:20,031 COSTS IN ACTIVE AWARDS AT THE 805 00:28:20,098 --> 00:28:21,666 TIME OF REVIEW, AND THE NEW 806 00:28:21,733 --> 00:28:24,736 CHANGES CLARIFY THAT ALL 807 00:28:24,803 --> 00:28:26,604 APPLICATIONS WITH ANY 808 00:28:26,671 --> 00:28:27,472 WELL-FUNDED INVESTIGATOR WILL 809 00:28:27,539 --> 00:28:29,240 NEED TO GO THROUGH THE SPECIAL 810 00:28:29,307 --> 00:28:31,509 COUNCIL REVIEW PROCESS AND WE 811 00:28:31,576 --> 00:28:34,045 WILL NO LONGER ACCEPT 812 00:28:34,112 --> 00:28:36,681 APPLICATIONS THAT HAVE MULTIPLE 813 00:28:36,748 --> 00:28:40,051 PIs, ONLY ONE OR NOT ALL OF 814 00:28:40,118 --> 00:28:42,787 WHOM HAVE -- ARE WELL-FUNDED. 815 00:28:42,854 --> 00:28:44,889 THIS IS BECAUSE WE RECOGNIZE AS 816 00:28:44,956 --> 00:28:47,725 WE'VE CONSULTED WITH YOU ON THIS 817 00:28:47,792 --> 00:28:49,561 THAT MANY INVESTIGATORS SEEM TO 818 00:28:49,627 --> 00:28:52,430 BE USING THIS MULTIPLE PI 819 00:28:52,497 --> 00:28:54,599 PROCESS AS A WAY TO GET AROUND 820 00:28:54,666 --> 00:28:56,901 OUR CONCERNS ABOUT THE 821 00:28:56,968 --> 00:28:57,769 CONCENTRATION OF FUNDS. 822 00:28:57,836 --> 00:28:59,404 WE WILL STILL BE ABLE TO FUND 823 00:28:59,471 --> 00:29:06,311 SUCH INVESTIGATORS IF THE 824 00:29:06,377 --> 00:29:07,278 APPLICATIONS MEET THE CRITERIA 825 00:29:07,345 --> 00:29:08,613 YOU ALL HELPED US ESTABLISH, BUT 826 00:29:08,680 --> 00:29:10,248 THIS WAY, IT WILL MAKE SURE WE 827 00:29:10,315 --> 00:29:11,683 BRING MORE OF THESE APPLICATIONS 828 00:29:11,749 --> 00:29:16,020 INTO CONSIDERATION IN THIS BODY. 829 00:29:16,087 --> 00:29:21,059 I WANT TO JUST HIGHLIGHT A 830 00:29:21,126 --> 00:29:22,060 COUPLE OF INITIATIVES THAT YOU 831 00:29:22,127 --> 00:29:23,461 ALL HAVE WORKED ON, IN 832 00:29:23,528 --> 00:29:26,965 PARTICULAR THE IMPACT INITIA 833 00:29:27,031 --> 00:29:28,600 INITIATIVE, IMPACT MH 834 00:29:28,666 --> 00:29:28,933 INITIATIVE. 835 00:29:29,000 --> 00:29:30,135 THIS IS, OF COURSE, THE ONE THAT 836 00:29:30,201 --> 00:29:34,205 SEEKS TO FUND RESEARCH IN A 837 00:29:34,272 --> 00:29:35,306 COORDINATED FASHION THAT 838 00:29:35,373 --> 00:29:39,844 INVOLVES DELIVERING BIOMARKERS 839 00:29:39,911 --> 00:29:42,180 AND OTHER MEASURES TO LARGE 840 00:29:42,247 --> 00:29:45,150 COHORTS OF INDIVIDUALS WITH 841 00:29:45,216 --> 00:29:47,218 ACCESS TO CLINICAL RECORDS TO 842 00:29:47,285 --> 00:29:49,687 TRY TO DO BETTER WITH ADDITIONAL 843 00:29:49,754 --> 00:29:50,155 INFORMATION. 844 00:29:50,221 --> 00:29:51,589 WE'RE STILL WORKING THROUGH 845 00:29:51,656 --> 00:29:53,124 FUNDING, THE AWARDS THAT YOU 846 00:29:53,191 --> 00:29:54,192 APPROVED BACK IN FEBRUARY, BUT 847 00:29:54,259 --> 00:29:55,527 ABOUT HALF OF THEM HAVE BEEN 848 00:29:55,593 --> 00:29:56,728 AWARDED TO DATE, AND JUST IN 849 00:29:56,794 --> 00:29:59,564 TERMS OF AN OVERVIEW OF THESE 850 00:29:59,631 --> 00:30:01,432 AWARDS, THE AGE RANGES INCLUDE 851 00:30:01,499 --> 00:30:02,967 BOTH KIDS AND ADULTS. 852 00:30:03,034 --> 00:30:05,270 THE POPULATIONS ARE GENERAL 853 00:30:05,336 --> 00:30:06,804 POPULATIONS, GENERAL POPULATION 854 00:30:06,871 --> 00:30:10,842 OR HEALTHCARE SYSTEM POPULAT 855 00:30:10,909 --> 00:30:11,176 POPULATIONS. 856 00:30:11,242 --> 00:30:12,243 CONSTRUCTS TO BE EXPLORED 857 00:30:12,310 --> 00:30:13,678 THROUGH THESE BIOMARKERS AND 858 00:30:13,745 --> 00:30:16,648 OTHER MEASURES ARE VERY -- BY 859 00:30:16,714 --> 00:30:18,283 THE MEASURES THEMSELVES AND THE 860 00:30:18,349 --> 00:30:19,817 OUTCOMES THAT WILL TRY TO BE 861 00:30:19,884 --> 00:30:23,121 PREDICTED FROM THESE MEASURES. 862 00:30:23,188 --> 00:30:24,322 WE'RE VERY EXCITED ABOUT THESE. 863 00:30:24,389 --> 00:30:25,723 A FEW OF THE AWARDS THAT HAVE 864 00:30:25,790 --> 00:30:28,459 BEEN GIVEN OUT SO WE CAN MAKE 865 00:30:28,526 --> 00:30:29,661 THEM PUBLIC INCLUDE EFFORT TO 866 00:30:29,727 --> 00:30:31,229 DEVELOP DATA-DRIVEN CLINICAL 867 00:30:31,296 --> 00:30:33,598 SIGNATURES FOR PEOPLE WITH 868 00:30:33,665 --> 00:30:34,699 PSYCHOSIS, PARTICULARLY THOSE 869 00:30:34,766 --> 00:30:36,668 WHO EXPERIENCE HALLUCINATIONS, 870 00:30:36,734 --> 00:30:38,303 AND AN EFFORT TO LEVERAGE 871 00:30:38,369 --> 00:30:41,606 MULTIPLE TYPES OF DATA TO 872 00:30:41,673 --> 00:30:43,875 DEVELOP AND VALIDATE SLEEP 873 00:30:43,942 --> 00:30:45,710 SIGNATURES IN PERIADOLESCENT 874 00:30:45,777 --> 00:30:47,645 CHILDREN. 875 00:30:47,712 --> 00:30:49,280 ANOTHER HIGHLIGHT FROM THE WORK 876 00:30:49,347 --> 00:30:54,385 THAT YOU ALL HAVE DONE OVER THE 877 00:30:54,452 --> 00:30:56,688 YEARS, THIS BODY AS WELL AS NIMH 878 00:30:56,754 --> 00:30:59,190 HAS SUPPORTED THE PSYCHENCODE 879 00:30:59,257 --> 00:31:00,058 INITIATIVE, WHICH IS AN EFFORT 880 00:31:00,124 --> 00:31:02,360 TO UNDERSTAND THE RELATIONSHIP 881 00:31:02,427 --> 00:31:05,096 BETWEEN GENETIC RISK AND GENE 882 00:31:05,163 --> 00:31:06,531 EXPRESS AND OTHER BIOLOGICAL 883 00:31:06,598 --> 00:31:09,467 FACTORS AT THE CELLULAR LEVEL. 884 00:31:09,534 --> 00:31:13,538 THE PHASE ONE RESULTS WERE 885 00:31:13,605 --> 00:31:14,839 TREMENDOUS, PUBLISHED BETWEEN 886 00:31:14,906 --> 00:31:16,407 2015 AND 2019. 887 00:31:16,474 --> 00:31:21,212 AND PHASE TWO JUST WAS PUBLISHED 888 00:31:21,279 --> 00:31:26,985 WITH A TOTAL OF 14 PAPERS, 889 00:31:27,051 --> 00:31:28,219 SPECIFICALLY DETAILING WHERE, 890 00:31:28,286 --> 00:31:31,089 HOW AND WHEN IN THE BRAIN 891 00:31:31,155 --> 00:31:32,357 GENETIC RISK FOR PSYCHIATRIC 892 00:31:32,423 --> 00:31:33,391 CONDITIONS AFFECT THE HUMAN 893 00:31:33,458 --> 00:31:33,891 BRAIN. 894 00:31:33,958 --> 00:31:39,697 I ENCOURAGE YOU TO VISIT THESE 895 00:31:39,764 --> 00:31:41,899 PUBLICATIONS, BUT JUST TO 896 00:31:41,966 --> 00:31:44,636 SUMMARIZE THE MAIN FINDINGS, THE 897 00:31:44,702 --> 00:31:47,572 SCIENTISTS FOUND THAT POPULATION 898 00:31:47,639 --> 00:31:49,340 LEVEL SINGLE CELL MULTI-OMIC 899 00:31:49,407 --> 00:31:51,609 ANALYSES CAN MAP GENE VARIANTS, 900 00:31:51,676 --> 00:31:53,578 REGULATORY ELEMENTS AND 901 00:31:53,645 --> 00:31:54,579 TRANSCRIPTIONAL ISOFORMS TO 902 00:31:54,646 --> 00:31:56,881 SPECIFIC REGULATORY NETWORKS AT 903 00:31:56,948 --> 00:32:00,618 CELLULAR RESOLUTION IN DEVEL 904 00:32:00,685 --> 00:32:00,918 DEVELOPMENT. 905 00:32:00,985 --> 00:32:02,787 WE'VE NOW IN PHASE TWO EXTENDED 906 00:32:02,854 --> 00:32:05,323 THESE FINDINGS FROM BOTH TISSUE 907 00:32:05,390 --> 00:32:08,259 TO SINGLE CELLS, SO THAT WE CAN 908 00:32:08,326 --> 00:32:09,560 MAP DIFFERENT CELL TYPES 909 00:32:09,627 --> 00:32:11,729 AFFECTED BY GENETIC RISK FOR 910 00:32:11,796 --> 00:32:14,766 HUMAN NEUROPSYCHIATRIC DISORD 911 00:32:14,832 --> 00:32:15,800 DISORDERS. 912 00:32:15,867 --> 00:32:16,567 THEY ESTABLISHED THE VALIDATION 913 00:32:16,634 --> 00:32:18,870 OF VARIOUS FUNCTIONAL READOUTS 914 00:32:18,936 --> 00:32:20,505 IN NEUROPSYCHIATRIC DISORDERS AS 915 00:32:20,571 --> 00:32:22,607 WELL AS TOOLS TO ANALYZE AND 916 00:32:22,674 --> 00:32:29,480 EXPLORE THE DATASETS. 917 00:32:29,547 --> 00:32:34,185 I CAN'T EMPHASIZE MORE WORK LIKE 918 00:32:34,252 --> 00:32:35,153 THE SECOND INITIATIVE. 919 00:32:35,219 --> 00:32:38,222 THIS IS A TEAM-BASED APPROACH 920 00:32:38,289 --> 00:32:41,125 OVER YEARS TO DELVE DEEPER, AND 921 00:32:41,192 --> 00:32:42,393 WE KNOW THIS IS GOING TO BE 922 00:32:42,460 --> 00:32:42,894 REALLY IMPORTANT. 923 00:32:42,960 --> 00:32:44,462 IT'S A LONG-TERM GAME, THOUGH, 924 00:32:44,529 --> 00:32:45,463 SO IT'S UP WITH OF THE AREAS 925 00:32:45,530 --> 00:32:49,434 THAT WE HAVE INVESTED IN IN THE 926 00:32:49,500 --> 00:32:50,134 LONG TERM. 927 00:32:50,201 --> 00:32:51,903 TURNING FROM SCIENCE A MOMENT -- 928 00:32:51,969 --> 00:32:55,740 FOR A MOMENT TO PEOPLE, I'M 929 00:32:55,807 --> 00:32:57,675 REALLY SAD TO RECOGNIZE THE 930 00:32:57,742 --> 00:33:00,645 PASSING OF DR. HERB PARDES, WHO 931 00:33:00,712 --> 00:33:03,414 SERVED AS DIRECTOR OF NIMH IN 932 00:33:03,481 --> 00:33:07,418 THE LATE 1970S AND EARLY 933 00:33:07,485 --> 00:33:07,985 1980s. 934 00:33:08,052 --> 00:33:12,890 HERB WAS A GIANT IN OUR FIELD. 935 00:33:12,957 --> 00:33:14,325 NOT ONLY HAD HE BEEN DIRECTOR OF 936 00:33:14,392 --> 00:33:16,561 NIMH BUT HE WAS CHAIR OF 937 00:33:16,627 --> 00:33:17,628 MULTIPLE DEPARTMENTS OF 938 00:33:17,695 --> 00:33:20,365 PSYCHIATRY AS WELL AS DE DEAN OA 939 00:33:20,431 --> 00:33:21,999 MEDICAL SCHOOL AND CEO OF A 940 00:33:22,066 --> 00:33:23,901 HOSPITAL. 941 00:33:23,968 --> 00:33:24,635 IMPORTANTLY FOR MENTAL HEALTH 942 00:33:24,702 --> 00:33:27,004 RESEARCH, HE ALSO FOUNDED WHAT 943 00:33:27,071 --> 00:33:28,473 WAS THEN CALLED THE NATIONAL 944 00:33:28,539 --> 00:33:31,442 ALLIANCE FOR RESEARCH IN 945 00:33:31,509 --> 00:33:34,379 SCHIZOPHRENIA AND DEPRESSION, 946 00:33:34,445 --> 00:33:37,115 WHICH HAS BEEN A TREMENDOUS 947 00:33:37,181 --> 00:33:39,417 SOURCE OF SUPPORT, ESPECIALLY 948 00:33:39,484 --> 00:33:43,054 FOR EARLY CAREER INVESTIGATORS, 949 00:33:43,121 --> 00:33:44,822 INCLUDING MYSELF, I RECEIVED 950 00:33:44,889 --> 00:33:45,890 AWARDS EARLY ON IN THE COURSE OF 951 00:33:45,957 --> 00:33:48,326 MY TRAINING, AND IT HELPED ME 952 00:33:48,393 --> 00:33:49,761 DEVELOP AS A SCIENTIST 953 00:33:49,827 --> 00:33:50,294 TREMENDOUSLY. 954 00:33:50,361 --> 00:33:51,929 SO HERB HAS HAD AN IMPACT ON 955 00:33:51,996 --> 00:33:53,564 MANY IN THE FIELD AND WILL BE 956 00:33:53,631 --> 00:33:58,403 MISSED. 957 00:33:58,469 --> 00:33:59,937 WE ALSO HAVE SEVERAL NIMH STAFF 958 00:34:00,004 --> 00:34:02,473 WHO HAVE MOVED ON FROM WORK AND 959 00:34:02,540 --> 00:34:04,308 INTO RETIERM. 960 00:34:04,375 --> 00:34:06,511 DR. SUSAN AZRIN, CHIEF OF THE 961 00:34:06,577 --> 00:34:08,179 EARLY PSYCHOSIS PREDICTION AND 962 00:34:08,246 --> 00:34:10,014 PREVENTION UNIT IN NIMH RETIRED 963 00:34:10,081 --> 00:34:13,317 FROM FEDERAL SERVICE IN MARCH. 964 00:34:13,384 --> 00:34:20,992 AND DR. ELLEN LEIBENLUFT RETIRED 965 00:34:21,058 --> 00:34:22,093 AFTER 34 YEARS OF SERVICE IN 966 00:34:22,160 --> 00:34:23,194 JULY. 967 00:34:23,261 --> 00:34:28,332 ON A HAPPIER NOTE, SARAH MORRIS, 968 00:34:28,399 --> 00:34:30,835 BRANCH CHIEF OF THE ADULT 969 00:34:30,902 --> 00:34:32,370 PSYCHOPATHOLOGY AND PSYCHOSOCIAL 970 00:34:32,437 --> 00:34:33,337 INTERVENTIONS RESEARCH BRANCH 971 00:34:33,404 --> 00:34:37,508 HAS BEEN HEADED THE HEAD OF THE 972 00:34:37,575 --> 00:34:38,376 RDOC UNIT. 973 00:34:38,443 --> 00:34:40,144 SARAH HAS BEEN SERVING IN THAT 974 00:34:40,211 --> 00:34:42,980 CAPACITY FOR SOME TIME BUT 975 00:34:43,047 --> 00:34:47,585 RECOGNIZED FORMALLY IN MAY. 976 00:34:47,652 --> 00:34:48,052 MAY. 977 00:34:48,119 --> 00:34:51,622 SHE HAS PLAYED AN IMPORTANT 978 00:34:51,689 --> 00:34:52,523 ROLE, AS WELL AS IN 979 00:34:52,590 --> 00:34:53,491 COLLABORATIONS WITH THE 980 00:34:53,558 --> 00:34:54,192 ALL-OF-US COHORT. 981 00:34:54,258 --> 00:34:56,594 OTHER NEWS IN THE IRP, 982 00:34:56,661 --> 00:34:59,664 INTRAMURAL RESEARCH PROGRAM, 983 00:34:59,730 --> 00:35:03,501 JANET CLARK HAS BEEN NAMED A 984 00:35:03,568 --> 00:35:04,936 FELLOW IN THE AMERICAN SOCIETY 985 00:35:05,002 --> 00:35:07,772 FOR PHARMACOLOGY AND 986 00:35:07,839 --> 00:35:08,906 EXPERIMENTAL THERAPEUTICS AS 987 00:35:08,973 --> 00:35:10,408 WELL AS A FELLOW OF THE AMERICAN 988 00:35:10,475 --> 00:35:12,143 COLLEGE OF 989 00:35:12,210 --> 00:35:13,978 NEUROPSYCHOPHARMACOLOGY. 990 00:35:14,045 --> 00:35:17,949 AND DR. ARMIN RAZNAHAN ELECTED 991 00:35:18,015 --> 00:35:19,250 TO THE AMERICAN SOCIETY FOR 992 00:35:19,317 --> 00:35:20,718 CLINICAL INVESTIGATION. 993 00:35:20,785 --> 00:35:21,652 FINALLY, AS ALWAYS I'LL CLOSE 994 00:35:21,719 --> 00:35:22,954 WITH A FEW SCIENCE HIGHLIGHTS 995 00:35:23,020 --> 00:35:25,289 FROM THE WORK THAT'S DONE WITH 996 00:35:25,356 --> 00:35:27,358 NIMH SUPPORT AND WORK THAT IS 997 00:35:27,425 --> 00:35:30,194 DONE HERE AS WELL IN THE 998 00:35:30,261 --> 00:35:31,529 INTRAMURAL RESEARCH PROGRAM. 999 00:35:31,596 --> 00:35:32,530 THE FIRST SCIENCE HIGHLIGHT 1000 00:35:32,597 --> 00:35:33,931 ACTUALLY FOCUSES ON A HIGHLIGHT 1001 00:35:33,998 --> 00:35:36,033 THAT I SHOULD SAY BUILDS UPON A 1002 00:35:36,100 --> 00:35:38,769 HIGHLIGHT THAT I GAVE SOME TIME 1003 00:35:38,836 --> 00:35:39,537 AGO. 1004 00:35:39,604 --> 00:35:40,738 AND THIS IS NOT THE RIGHT 1005 00:35:40,805 --> 00:35:41,439 PRESENTATION. 1006 00:35:41,506 --> 00:35:48,279 OH, WELL. 1007 00:35:48,346 --> 00:35:50,815 I'LL MAKE DO. 1008 00:35:50,882 --> 00:35:54,085 SO IT IS THE RIGHT PAPER, 1009 00:35:54,151 --> 00:35:58,022 THOUGH, BY SERGIU PASC A AND 1010 00:35:58,089 --> 00:35:59,423 COLLEAGUES AT STANFORD WHO HAVE 1011 00:35:59,490 --> 00:36:00,525 BEEN PIONEERING APPROACHES FOR 1012 00:36:00,591 --> 00:36:04,028 THE STUDY OF PARTICULARLY 1013 00:36:04,095 --> 00:36:05,229 GENETIC RISK FOR PSYCHIATRIC 1014 00:36:05,296 --> 00:36:08,065 DISORDERS AND NEURODEVELOPMENTAL 1015 00:36:08,132 --> 00:36:09,934 DISORDERS USING ORGANOIDS. 1016 00:36:10,001 --> 00:36:11,135 ORGANOIDS ARE, OF COURSE, SMALL 1017 00:36:11,202 --> 00:36:13,771 ASSEMBLIES OF BRAIN TISSUE THAT 1018 00:36:13,838 --> 00:36:16,741 ARE BUILT, IF YOU WILL, OR GROWN 1019 00:36:16,807 --> 00:36:18,509 FROM HUMAN STEM CELLS, AND THEY 1020 00:36:18,576 --> 00:36:20,912 CAN BE GROWN FROM THE STEM CELLS 1021 00:36:20,978 --> 00:36:22,246 OF PATIENTS, OF INDIVIDUAL 1022 00:36:22,313 --> 00:36:23,347 PATIENTS. 1023 00:36:23,414 --> 00:36:24,315 AND I TOLD YOU SOME TIME AGO 1024 00:36:24,382 --> 00:36:26,717 ABOUT A PROCESS THAT HE 1025 00:36:26,784 --> 00:36:30,354 DEVELOPED TO ENSURE A 1026 00:36:30,421 --> 00:36:32,423 GREATER DEGREE OF MATURATION OF 1027 00:36:32,490 --> 00:36:34,859 THESE ASSEMBLIES, SO-CALLED 1028 00:36:34,926 --> 00:36:35,426 ORGANOIDS. 1029 00:36:35,493 --> 00:36:37,261 SO IF YOU GROW HUMAN STEM CELLS 1030 00:36:37,328 --> 00:36:39,130 IN A DISH AND DIFFERENTIATE THEM 1031 00:36:39,196 --> 00:36:42,500 INTO NEURAL TISSUE, THEY CAN 1032 00:36:42,567 --> 00:36:46,003 DEVELOP AND MATURE SOMEWHAT, 1033 00:36:46,070 --> 00:36:48,973 MAYBE TO THE POINT WHERE THE 1034 00:36:49,040 --> 00:36:51,509 NEURONAL ASSEMBLIES KIND OF LOOK 1035 00:36:51,576 --> 00:36:52,710 LIKE HUMAN TISSUE THAT'S ABOUT 1036 00:36:52,777 --> 00:36:54,779 THE AGE THAT A BRAIN IS WHEN A 1037 00:36:54,845 --> 00:36:58,082 BABY IS BORN. 1038 00:36:58,149 --> 00:36:59,817 BUT WE NEED TO BE ABLE TO STUDY 1039 00:36:59,884 --> 00:37:01,586 HUMAN TISSUE IN A MORE MATURE 1040 00:37:01,652 --> 00:37:03,988 STATE, SO TO UNDERSTAND THE FULL 1041 00:37:04,055 --> 00:37:04,989 NEURODEVELOPMENTAL PROCESSES 1042 00:37:05,056 --> 00:37:06,023 THAT RESULT IN 1043 00:37:06,090 --> 00:37:06,724 NEURODEVELOPMENTAL DISORDERS. 1044 00:37:06,791 --> 00:37:08,693 AND SO WHAT I TOLD YOU ABOUT 1045 00:37:08,759 --> 00:37:11,629 BEFORE IS THE TECHNIQUE THAT DRS 1046 00:37:11,696 --> 00:37:13,331 DEVELOPED TO BE ABLE TO TAKE 1047 00:37:13,397 --> 00:37:14,966 THESE ASSEMBLIES OF HUMAN TISSUE 1048 00:37:15,032 --> 00:37:17,802 AND IMPLANT THEM INTO A MOUSE 1049 00:37:17,868 --> 00:37:20,137 BRAIN THAT WILL ALLOW THAT 1050 00:37:20,204 --> 00:37:23,841 TISSUE TO FURTHER DEVELOP TO 1051 00:37:23,908 --> 00:37:24,942 MAYBE A YEAR OF LIFE OR TWO 1052 00:37:25,009 --> 00:37:25,476 YEARS OF LIFE. 1053 00:37:25,543 --> 00:37:27,478 WE'RE NOT EXACTLY SURE YET HOW 1054 00:37:27,545 --> 00:37:28,980 MATURE THIS TISSUE CAN GET. 1055 00:37:29,046 --> 00:37:30,314 BUT IT GETS MATURE ENOUGH THAT 1056 00:37:30,381 --> 00:37:33,384 YOU CAN IDENTIFY -- SORRY, THIS 1057 00:37:33,451 --> 00:37:34,752 IS THE SLIDE THAT DIDN'T MAKE IT 1058 00:37:34,819 --> 00:37:35,920 INTO THE PRESENTATION I TRIED TO 1059 00:37:35,987 --> 00:37:36,554 ADD THIS MORNING. 1060 00:37:36,621 --> 00:37:40,191 MY FAULT FOR BEING LATE AT THIS. 1061 00:37:40,257 --> 00:37:42,259 IT DEVELOPS IN A MATURE ENOUGH 1062 00:37:42,326 --> 00:37:43,761 WAY THAT YOU CAN DEMONSTRATE 1063 00:37:43,828 --> 00:37:46,430 DIFFERENCES IN THE STRUCTURE AND 1064 00:37:46,497 --> 00:37:48,399 FUNCTION OF NEURONS, HUMAN 1065 00:37:48,466 --> 00:37:50,167 NEURONS THAT ARE GROWING UP IN 1066 00:37:50,234 --> 00:37:52,236 THESE ASSEMBLIES, BASED UPON 1067 00:37:52,303 --> 00:37:53,571 GENETIC RISK, FOR EXAMPLE, IN 1068 00:37:53,638 --> 00:37:58,376 THIS CASE, A GENETIC RISK FOR A 1069 00:37:58,442 --> 00:37:59,477 NEURODEVELOPMENTAL SYNDROME 1070 00:37:59,543 --> 00:38:02,213 CALLED TIMOTHY SYNDROME, WHICH 1071 00:38:02,279 --> 00:38:03,314 DR. PASCA AND COLLEAGUES HAVE 1072 00:38:03,381 --> 00:38:06,951 BEEN STUDYING FOR SOME TIME. 1073 00:38:07,018 --> 00:38:08,152 AND LET ME MOVE FORWARD JUST A 1074 00:38:08,219 --> 00:38:15,793 LITTLE BIT. 1075 00:38:15,860 --> 00:38:17,128 THIS IS WHAT I SHOWED YOU 1076 00:38:17,194 --> 00:38:19,497 BEFORE, YOU CAN GROW ON THE 1077 00:38:19,563 --> 00:38:20,631 LEFT-HAND LOWER SIDE A CHUNK OF 1078 00:38:20,698 --> 00:38:22,266 HUMAN TISSUE ON TOP, IN THIS 1079 00:38:22,333 --> 00:38:24,902 CASE OF A RAT CORTEX, AND IT 1080 00:38:24,969 --> 00:38:25,736 MATURES AND ON THE RIGHT-HAND 1081 00:38:25,803 --> 00:38:26,971 SIDE, YOU CAN SEE THAT TISSUE 1082 00:38:27,038 --> 00:38:31,042 THAT'S DERIVED FROM A HUMAN -- A 1083 00:38:31,108 --> 00:38:32,810 HUMAN TISSUE WITHOUT THIS 1084 00:38:32,877 --> 00:38:34,545 TIMOTHY SYNDROME, THE NEURONS 1085 00:38:34,612 --> 00:38:36,614 DEVELOP THESE QUITE COMPLEX 1086 00:38:36,681 --> 00:38:38,749 ARBORS OF DENDRITES, THOSE ARE 1087 00:38:38,816 --> 00:38:41,285 THE THIN BLACK LINES EMANATING 1088 00:38:41,352 --> 00:38:43,421 FROM THE NEURON THAT YOU SEE ON 1089 00:38:43,487 --> 00:38:44,722 THE LEFT-HAND SIDE OF THAT LOWER 1090 00:38:44,789 --> 00:38:45,990 RIGHT PANEL. 1091 00:38:46,057 --> 00:38:47,158 ON THE RIGHT-HAND SIDE, YOU SEE 1092 00:38:47,224 --> 00:38:49,026 A NEURON THAT'S DERIVED FROM 1093 00:38:49,093 --> 00:38:51,529 HUMAN TISSUE FROM A STEM CELL 1094 00:38:51,595 --> 00:38:53,931 THAT DERIVED FROM A PATIENT WITH 1095 00:38:53,998 --> 00:38:54,932 TIMOTHY SYNDROME, AND YOU CAN 1096 00:38:54,999 --> 00:38:57,401 SEE THAT THAT ARBOR OF DENDRITES 1097 00:38:57,468 --> 00:39:00,671 IS NOT AS ELABORATE. 1098 00:39:00,738 --> 00:39:02,606 THAT'S ONE OF SEVERAL PHENOTYPES 1099 00:39:02,673 --> 00:39:05,209 THAT DR. PASCA'S GROUP WAS ABLE 1100 00:39:05,276 --> 00:39:06,844 TO IDENTIFY BY STUDYING THIS 1101 00:39:06,911 --> 00:39:09,013 HUMAN TISSUE IN A MOUSE. 1102 00:39:09,080 --> 00:39:11,115 BUT NOW HE'S GONE ONE STEP 1103 00:39:11,182 --> 00:39:14,618 FURTHER AND TRIED TO USE THIS 1104 00:39:14,685 --> 00:39:16,487 TOOL TO SEE IF HE CAN DEVELOP A 1105 00:39:16,554 --> 00:39:20,624 POTENTIAL TREATMENT. 1106 00:39:20,691 --> 00:39:22,293 SO IT TURNS OUT THAT ONE OF THE 1107 00:39:22,359 --> 00:39:25,362 CONSEQUENCES OF THE MUTATION IN 1108 00:39:25,429 --> 00:39:27,231 A CALCIUM CHANNEL GENE THAT 1109 00:39:27,298 --> 00:39:30,634 CAUSES TIMOTHY SYNDROME IS THE 1110 00:39:30,701 --> 00:39:32,069 OVEREXPRESSION OF ONE PARTICULAR 1111 00:39:32,136 --> 00:39:34,138 FORM OF THIS CALCIUM CHANNEL, 1112 00:39:34,205 --> 00:39:37,308 IT'S A FORM THAT INCLUDES A 1113 00:39:37,374 --> 00:39:40,711 PIECE OF THE GENETIC CODE CALLED 1114 00:39:40,778 --> 00:39:41,579 AXON 8A. 1115 00:39:41,645 --> 00:39:45,950 AND YOU CAN REDUCE THIS ABNORMAL 1116 00:39:46,016 --> 00:39:49,687 FORM OF THE PROTEIN WITH A SMALL 1117 00:39:49,754 --> 00:39:55,493 MOLECULE CALLED AN ANTISENSE 1118 00:39:55,559 --> 00:39:57,027 OLIGONUCLEOTIDE, WHICH HAVE BEEN 1119 00:39:57,094 --> 00:39:58,329 USED ALREADY IN TREATMENT OF 1120 00:39:58,395 --> 00:39:59,764 GENETIC DISORDERS IN THE 1121 00:39:59,830 --> 00:40:00,531 NEUROLOGY SPACE. 1122 00:40:00,598 --> 00:40:02,066 SO WE KNOW THEY CAN BE USED IN 1123 00:40:02,133 --> 00:40:05,669 THE CENTRAL NERVOUS SYSTEM TO 1124 00:40:05,736 --> 00:40:08,973 TREAT GENETIC DISORDERS. 1125 00:40:09,039 --> 00:40:12,376 SO THIS ANTISENSE OLIGOKNEW CLEE 1126 00:40:12,443 --> 00:40:13,010 OLIGONUCLEOTIDE ON THE LEFT 1127 00:40:13,077 --> 00:40:14,678 PANEL REDUCES THE EXPRESSION OF 1128 00:40:14,745 --> 00:40:18,082 THIS ABERRANT EXON 8A CONTAINING 1129 00:40:18,149 --> 00:40:20,151 CALCIUM CHANNEL PROTEIN IN RATS, 1130 00:40:20,217 --> 00:40:22,686 AND IT ALSO DOES IT ON THE RIGHT 1131 00:40:22,753 --> 00:40:24,388 SIDE IN HUMANS. 1132 00:40:24,455 --> 00:40:26,457 WHERE THE GREEN BAR IS THE HIGH 1133 00:40:26,524 --> 00:40:29,193 LEVELS OF EXON 8A CONTAINING 1134 00:40:29,260 --> 00:40:31,495 PROTEIN IN HUMAN TISSUE DERIVED 1135 00:40:31,562 --> 00:40:34,899 FROM TIMOTHY SYNDROME PATIENTS 1136 00:40:34,965 --> 00:40:37,334 AND IN THE PURPLE IS THE REDUCED 1137 00:40:37,401 --> 00:40:41,605 LEVEL OF THAT EXON 8A CONTAINING 1138 00:40:41,672 --> 00:40:43,908 PROTEIN ONCE THAT HUMAN TISSUE 1139 00:40:43,974 --> 00:40:46,110 IS TREATED WITH THE ANTISENSE 1140 00:40:46,177 --> 00:40:48,212 OLIGONUCLEOTIDE. 1141 00:40:48,279 --> 00:40:49,180 IT TURNS OUT OF COURSE YOU'RE 1142 00:40:49,246 --> 00:40:51,515 NOT JUST REVERSING THIS PROTEIN. 1143 00:40:51,582 --> 00:40:55,219 YOU'RE ALSO REVERSING SOME KEY 1144 00:40:55,286 --> 00:40:56,453 PHENOTYPES THAT WE THINK MAY BE 1145 00:40:56,520 --> 00:40:59,623 RESPONSIBLE FOR THE 1146 00:40:59,690 --> 00:41:00,891 NEURODEVELOPMENTAL CHALLENGES 1147 00:41:00,958 --> 00:41:01,725 THAT INDIVIDUALS WITH TIMOTHY 1148 00:41:01,792 --> 00:41:02,159 SYNDROME FACE. 1149 00:41:02,226 --> 00:41:04,295 SO HERE ON THE UPPER PART OF THE 1150 00:41:04,361 --> 00:41:07,198 RIGHT SIDE IS AN EXAMPLE NEURON 1151 00:41:07,264 --> 00:41:08,699 GROWN IN ONE OF THESE ASSEMBLIES 1152 00:41:08,766 --> 00:41:13,537 IN A RAT FROM A CONTROL 1153 00:41:13,604 --> 00:41:14,772 INDIVIDUAL WITHOUT TIMOTHY 1154 00:41:14,839 --> 00:41:16,307 SYNDROME, TISSUE GROWN FROM AN 1155 00:41:16,373 --> 00:41:18,075 INDIVIDUAL WITH TIMOTHY 1156 00:41:18,142 --> 00:41:19,710 SYNDROME, NOT TREATED WITH THE 1157 00:41:19,777 --> 00:41:20,077 OLIGONUCLEOTIDE. 1158 00:41:20,144 --> 00:41:22,246 AND THEN ON THE RIGHT, YOU CAN 1159 00:41:22,313 --> 00:41:23,881 SEE AN EXAMPLE NEURON FROM 1160 00:41:23,948 --> 00:41:25,749 NEURAL TISSUE DERIVED FROM 1161 00:41:25,816 --> 00:41:26,750 TIMOTHY SYNDROME, BUT NOW 1162 00:41:26,817 --> 00:41:28,919 TREATED WITH THIS ANTISENSE 1163 00:41:28,986 --> 00:41:30,120 OLIGONUCLEOTIDE, AND IT RESTORES 1164 00:41:30,187 --> 00:41:33,224 THAT ELABORATE DENDRITIC GROWTH 1165 00:41:33,290 --> 00:41:35,292 THAT IS CHARACTERIZED AS NEURONS 1166 00:41:35,359 --> 00:41:40,231 AT THAT STAGE OF MATURITY. 1167 00:41:40,297 --> 00:41:41,999 THAT'S QUANTIFIED IN THE LOWER 1168 00:41:42,066 --> 00:41:43,634 GRAPH OF THE AFICIONADOS, BUT 1169 00:41:43,701 --> 00:41:45,135 THE BOTTOM LINE IS WE CAN USE 1170 00:41:45,202 --> 00:41:46,437 THESE TOOLS IN A VERY EXCITING 1171 00:41:46,503 --> 00:41:49,773 WAY TO FIGURE OUT HOW WE CAN 1172 00:41:49,840 --> 00:41:51,642 POTENTIALLY TREAT INDIVIDUALS 1173 00:41:51,709 --> 00:41:52,509 WITH NEURODEVELOPMENTAL 1174 00:41:52,576 --> 00:41:57,248 DISORDERS. 1175 00:41:57,314 --> 00:41:58,749 SO THAT'S THE FIRST SCIENCE 1176 00:41:58,816 --> 00:42:00,184 HIGHLIGHT, A PATH FROM GENETICS 1177 00:42:00,251 --> 00:42:02,152 TO TREATMENT THROUGH TOOLS AND 1178 00:42:02,219 --> 00:42:03,787 TECHNOLOGIES THAT HAVE BEEN 1179 00:42:03,854 --> 00:42:04,989 DEVELOPED OVER TIME WITH THE 1180 00:42:05,055 --> 00:42:06,323 SUPPORT OF NIMH FUNDS AND WITH 1181 00:42:06,390 --> 00:42:07,725 THE SUPPORT OF IN THAT 1182 00:42:07,791 --> 00:42:09,960 PARTICULAR CASE ALSO BRAND 1183 00:42:10,027 --> 00:42:14,431 INITIATIVE FUNDS. 1184 00:42:14,498 --> 00:42:14,899 ALSO GRANT 1185 00:42:14,965 --> 00:42:15,532 INITIATIVE FUNDS. 1186 00:42:15,599 --> 00:42:20,638 NOW WE'RE GOING TO TURN TO -- WE 1187 00:42:20,704 --> 00:42:25,175 KNOW BIPOLAR DISORDER -- ONE OF 1188 00:42:25,242 --> 00:42:27,044 THE MANY TOOLS THAT NIMH 1189 00:42:27,111 --> 00:42:33,717 RESEARCH HAS BROUGHT TO THE 1190 00:42:33,784 --> 00:42:34,852 COMMUNITY FOR TREATMENT OF 1191 00:42:34,919 --> 00:42:38,022 VARIOUS MENTAL ILLNESSES IS 1192 00:42:38,088 --> 00:42:38,689 DIALECTICAL BEHAVIORAL THERAPY, 1193 00:42:38,756 --> 00:42:41,458 WHICH IS PARTICULARLY GOOD AT 1194 00:42:41,525 --> 00:42:42,760 ASSISTING IN EMOTIONAL 1195 00:42:42,826 --> 00:42:45,362 REGULATION AND REDUCING SELF 1196 00:42:45,429 --> 00:42:46,130 INJURIOUS BEHAVIORS. 1197 00:42:46,196 --> 00:42:50,000 THIS GROUP TESTED THE ABILITY OF 1198 00:42:50,067 --> 00:42:50,901 DIALECTICAL BEHAVIORAL THERAPY 1199 00:42:50,968 --> 00:42:55,272 TO HELP INDIVIDUALS WITH BUY BIR 1200 00:42:55,339 --> 00:42:55,539 DISORDER. 1201 00:42:55,606 --> 00:42:56,840 AND IN PARTICULAR WHAT THEY 1202 00:42:56,907 --> 00:43:00,244 SHOWED IS THAT DIALECTICAL 1203 00:43:00,311 --> 00:43:01,111 BEHAVIORAL THERAPY AND STANDARD 1204 00:43:01,178 --> 00:43:03,314 OF CARE BOTH IMPROVE MOOD STATES 1205 00:43:03,380 --> 00:43:06,383 AND SYMPTOMS. 1206 00:43:06,450 --> 00:43:07,685 BUT DIALECTICAL BEHAVIORAL 1207 00:43:07,751 --> 00:43:09,119 THERAPY ADDED TO STANDARD OF 1208 00:43:09,186 --> 00:43:10,554 CARE REDUCES THE NUMBER OF 1209 00:43:10,621 --> 00:43:15,693 SUICIDE ATTEMPTS IN INDIVIDUALST 1210 00:43:15,759 --> 00:43:17,127 INDIVIDUALS WITH BIPOLAR 1211 00:43:17,194 --> 00:43:19,029 DISORDER WILL EXPERIENCE. 1212 00:43:19,096 --> 00:43:23,600 SO IT SUGGESTS THAT DBT MIGHT 1213 00:43:23,667 --> 00:43:24,802 HAVE A PARTICULAR ROLE IN THE 1214 00:43:24,868 --> 00:43:27,571 CARE OF INDIVIDUALS WITH BIPOLAR 1215 00:43:27,638 --> 00:43:29,340 DISORDER AT REDUCING SUICIDAL 1216 00:43:29,406 --> 00:43:32,509 BEHAVIORS. 1217 00:43:32,576 --> 00:43:35,579 FINALLY ONE LAST HIGHLIGHT, 1218 00:43:35,646 --> 00:43:37,014 RETURNING EVEN MORE BASIC TO 1219 00:43:37,081 --> 00:43:38,115 NEUROSCIENCE BUT THIS IS A 1220 00:43:38,182 --> 00:43:40,284 HIGHLIGHT THAT WAS RESEARCH DONE 1221 00:43:40,351 --> 00:43:42,820 IN OUR INTRAMURAL PROGRAM BY ONE 1222 00:43:42,886 --> 00:43:46,657 OF OUR VERY PROMISING 1223 00:43:46,724 --> 00:43:50,761 INVESTIGATORS, DRR ARASH AFRAZ. 1224 00:43:50,828 --> 00:43:52,196 ARASH IS REALLY INTERESTED IN 1225 00:43:52,262 --> 00:43:55,132 TRYING TO DEMONSTRATE THE ROLE 1226 00:43:55,199 --> 00:43:57,101 OF PARTICULAR COMPLEX FORMS OF 1227 00:43:57,167 --> 00:44:00,637 NEURAL ACTIVITY IN PERCEPTUAL 1228 00:44:00,704 --> 00:44:03,707 EXPERIENCES AND CONSCIOUSNESS. 1229 00:44:03,774 --> 00:44:04,775 HE DOES THIS IN A NUMBER OF 1230 00:44:04,842 --> 00:44:05,476 DIFFERENT WAYS. 1231 00:44:05,542 --> 00:44:07,344 THIS IS A PARTICULARLY CLEVER 1232 00:44:07,411 --> 00:44:12,483 EXPERIMENT, TRYING TO LINK A 1233 00:44:12,549 --> 00:44:14,451 PARTICULAR PATTERN OF NEURAL 1234 00:44:14,518 --> 00:44:16,787 ACTIVITY WITH A PARTICULAR 1235 00:44:16,854 --> 00:44:17,855 PERCEPTUAL EXPERIENCE, AND DOING 1236 00:44:17,921 --> 00:44:22,126 IT IN A VERY MECHANISTIC WAY IN 1237 00:44:22,192 --> 00:44:28,499 NON-HUMAN PRIMATES. 1238 00:44:28,565 --> 00:44:30,167 WE'VE KNOWN FOR A LONG TIME THAT 1239 00:44:30,234 --> 00:44:32,569 BOTH HUMANS AND NON-HUMAN 1240 00:44:32,636 --> 00:44:34,071 PRIMATES HAVE NEURONS IN THEIR 1241 00:44:34,138 --> 00:44:35,539 VISUAL SYSTEM CALLED THE FACE 1242 00:44:35,606 --> 00:44:37,241 PATCH AREA WHERE THE NEURONS ARE 1243 00:44:37,307 --> 00:44:38,809 PARTICULARLY SENSITIVE TO FACES, 1244 00:44:38,876 --> 00:44:40,611 AND INDEED A GIVEN NEURON MIGHT 1245 00:44:40,677 --> 00:44:41,812 BE RESPONSIVE TO A PARTICULAR 1246 00:44:41,879 --> 00:44:45,649 FACE. 1247 00:44:45,716 --> 00:44:48,152 SO THEY'RE KIND OF THE CANONICAL 1248 00:44:48,218 --> 00:44:49,086 GRANDMOTHER NEURONS IF YOU WILL, 1249 00:44:49,153 --> 00:44:50,154 WHEREAS YOU'LL HAVE NEURONS IN 1250 00:44:50,220 --> 00:44:51,588 YOUR BRAIN THAT RECOGNIZE FACES 1251 00:44:51,655 --> 00:44:52,790 AND EVEN RECOGNIZE SPECIFIC 1252 00:44:52,856 --> 00:44:53,390 FACES. 1253 00:44:53,457 --> 00:44:55,025 BUT JUST BECAUSE YOU HAVE THESE 1254 00:44:55,092 --> 00:44:56,326 NEURONS DOESN'T NECESSARILY MEAN 1255 00:44:56,393 --> 00:44:59,696 THAT THEY PARTICIPATE IN YOUR 1256 00:44:59,763 --> 00:45:02,466 ABILITY TO PERCEIVE A FACE. 1257 00:45:02,533 --> 00:45:03,834 MAYBE THEY'RE JUST AN ACCIDENT 1258 00:45:03,901 --> 00:45:06,637 OF THE FACT THAT THEY RESPOND TO 1259 00:45:06,703 --> 00:45:07,604 CIRCLES AND LINES OR SOMETHING 1260 00:45:07,671 --> 00:45:10,374 LIKE THAT, OR MAYBE THEY HAVE 1261 00:45:10,441 --> 00:45:12,443 SOME OTHER FUNCTIONAL PURPOSE. 1262 00:45:12,509 --> 00:45:14,445 SO FROM A SCIENTIFIC 1263 00:45:14,511 --> 00:45:15,312 PERSPECTIVE, IT'S REALLY 1264 00:45:15,379 --> 00:45:16,547 IMPORTANT THAT WE TRY TO 1265 00:45:16,613 --> 00:45:19,850 DEMONSTRATE CAUSAL RELATIONSHIPS 1266 00:45:19,917 --> 00:45:21,685 BETWEEN SPECIFIC PHENOMENA LIKE 1267 00:45:21,752 --> 00:45:24,788 FACE NEURONS AND THE PERCEPTUAL 1268 00:45:24,855 --> 00:45:26,657 EXPERIENCES THAT WE HYPOTHESIZE 1269 00:45:26,723 --> 00:45:28,859 THEY MEDIATE. 1270 00:45:28,926 --> 00:45:29,693 OTHERWISE, LET'S SUPPOSE WE'RE 1271 00:45:29,760 --> 00:45:32,896 TRYING TO HELP PEOPLE WITH 1272 00:45:32,963 --> 00:45:35,332 FACIAL AGNOSIA AND WE TRY TO 1273 00:45:35,399 --> 00:45:37,301 ENHANCE FACE NEURONS, WE MIGHT 1274 00:45:37,367 --> 00:45:39,069 NOT BE ABLE TO HELP THEM IN THAT 1275 00:45:39,136 --> 00:45:40,170 WAY, WE MIGHT NEED A DIFFERENT 1276 00:45:40,237 --> 00:45:41,805 WAY, SO IT'S REALLY IMPORTANT TO 1277 00:45:41,872 --> 00:45:43,140 ESTABLISH THOSE KINDS OF CAUSAL 1278 00:45:43,207 --> 00:45:45,976 RELATIONSHIPS. 1279 00:45:46,043 --> 00:45:47,411 THAT'S WHAT THIS EXPERIMENT DID. 1280 00:45:47,478 --> 00:45:50,047 SO DR. AFRAZ USED VARIOUS 1281 00:45:50,114 --> 00:45:52,149 METHODS TO ESTABLISH THE 1282 00:45:52,216 --> 00:45:57,087 LOCATION OF THE FACE PATCH IN 1283 00:45:57,154 --> 00:45:59,256 NON-HUMAN PRIMATES AND MACAQUE 1284 00:45:59,323 --> 00:46:01,024 MONKEYS. 1285 00:46:01,091 --> 00:46:07,498 THEN USING A DRUG CALLED 1286 00:46:07,564 --> 00:46:08,832 MUSCIMOL WHICH REVERSIBLY 1287 00:46:08,899 --> 00:46:11,034 SILENCES THIS BRAIN REGION, HE 1288 00:46:11,101 --> 00:46:11,935 INJECTED DIRECTLY INTO THE FACE 1289 00:46:12,002 --> 00:46:13,670 PATCH AND THEN MEASURED THE 1290 00:46:13,737 --> 00:46:15,506 ANIMAL AS THE ANIMAL LOOKED AT 1291 00:46:15,572 --> 00:46:17,407 PICTURES OF FACES. 1292 00:46:17,474 --> 00:46:18,509 NOW, WHEN YOU LOOK AT A PICTURE 1293 00:46:18,575 --> 00:46:20,043 OF A FACE, YOU DON'T LOOK AT ALL 1294 00:46:20,110 --> 00:46:22,613 THE PARTS OF THE FACE EQUALLY. 1295 00:46:22,679 --> 00:46:25,149 YOU LOOK AT THE EYES AND THE 1296 00:46:25,215 --> 00:46:26,183 MOUTH MORE THAN OTHER PARTS OF 1297 00:46:26,250 --> 00:46:26,650 THE FACE. 1298 00:46:26,717 --> 00:46:28,785 THAT'S A WELL-KNOWN PHENOMENON, 1299 00:46:28,852 --> 00:46:31,588 BECAUSE YOU PERCEIVE AS A FACE, 1300 00:46:31,655 --> 00:46:33,590 YOU PERCEIVE THOSE EYES AND YOU 1301 00:46:33,657 --> 00:46:35,025 FOCUS YOUR ATTENTION ON THE EYES 1302 00:46:35,092 --> 00:46:36,793 AND THE MOUTH. 1303 00:46:36,860 --> 00:46:38,529 NOW, EACH FACE PATCH, YOU HAVE 1304 00:46:38,595 --> 00:46:41,064 ONE ON EACH SIDE OF YOUR BRAIN, 1305 00:46:41,131 --> 00:46:43,934 AND THE FACE PATCH CONTROLS 1306 00:46:44,001 --> 00:46:45,569 PERCEPTIONS OF THE OPPOSITE SIDE 1307 00:46:45,636 --> 00:46:48,739 OF THE VISUAL WORLD. 1308 00:46:48,805 --> 00:46:53,477 SO DR. AFRASH HYPOTHESIZED THAT 1309 00:46:53,544 --> 00:46:55,979 INHIBITING THESE FACE-SELECTIVE 1310 00:46:56,046 --> 00:46:56,880 NEURONS SHOULD AFFECT THE 1311 00:46:56,947 --> 00:46:58,949 PERCEPTION OF THE OTHER SIDE OF 1312 00:46:59,016 --> 00:47:02,152 THE FACE WHEN THEY'RE LO LOOKINT 1313 00:47:02,219 --> 00:47:03,921 PICTURES, SO HE HYPOTHESIZED 1314 00:47:03,987 --> 00:47:05,989 THAT THE MONKEYS WOULD NOT BE 1315 00:47:06,056 --> 00:47:08,625 ABLE TO FOCUS ON THE EYES ON THE 1316 00:47:08,692 --> 00:47:09,960 OPPOSITE SIDE AND THAT'S EXACTLY 1317 00:47:10,027 --> 00:47:11,595 WHAT HE FOUND. 1318 00:47:11,662 --> 00:47:15,232 WHEN HE INHIBITED THE FACE PATCH 1319 00:47:15,299 --> 00:47:18,502 IN ONE SIDE OF THE BRAIN, THE 1320 00:47:18,569 --> 00:47:19,503 MONKEY'S ATTENTION TO THE EYE ON 1321 00:47:19,570 --> 00:47:21,605 THE OTHER SIDE OF THE FACE WAS 1322 00:47:21,672 --> 00:47:22,039 DISRUPTED. 1323 00:47:22,105 --> 00:47:24,675 IT DIDN'T MATTER WHICH SIDE, IT 1324 00:47:24,741 --> 00:47:28,512 ONLY MATTERED THE DOSE OF 1325 00:47:28,579 --> 00:47:29,613 MUSCIMOL HE INJECTED. 1326 00:47:29,680 --> 00:47:31,481 SO THIS AGAIN IS AN EXPERIMENT 1327 00:47:31,548 --> 00:47:32,683 WHICH HELPS US ESTABLISH A 1328 00:47:32,749 --> 00:47:35,953 CAUSAL RELATIONSHIP BETWEEN 1329 00:47:36,019 --> 00:47:39,823 ACTIVITY OF FACE CELLS AND THE 1330 00:47:39,890 --> 00:47:45,062 PERCEPTION OF A FACE. 1331 00:47:45,128 --> 00:47:46,496 SO WITH THAT I'M GOING TO CLOSE 1332 00:47:46,563 --> 00:47:47,864 THIS DIRECTOR'S UPDATE AND OPEN 1333 00:47:47,931 --> 00:47:49,933 IT UP TO QUESTIONS. 1334 00:47:50,000 --> 00:47:53,136 WE HAVE A FEW MINUTES, WE CAN BE 1335 00:47:53,203 --> 00:47:54,471 GENEROUS WITH QUESTIONS AND 1336 00:47:54,538 --> 00:47:55,005 COMMENTS FROM COUNCIL. 1337 00:47:55,072 --> 00:48:05,249 THANK YOU. 1338 00:48:14,825 --> 00:48:16,226 GO AHEAD. 1339 00:48:16,293 --> 00:48:17,027 >> THANK YOU. 1340 00:48:17,094 --> 00:48:18,061 MY FIRST QUESTION IS REALLY A 1341 00:48:18,128 --> 00:48:19,630 COMMENT AND IT REALLY A THANK 1342 00:48:19,696 --> 00:48:21,465 YOU, JOSH, FOR GIVING ALL OF 1343 00:48:21,531 --> 00:48:23,500 YOUR ENERGY, EFFORT, ENTHUSIASM 1344 00:48:23,567 --> 00:48:26,703 AND KNOWLEDGE AND EXPERIENCE TO 1345 00:48:26,770 --> 00:48:27,671 THE NATIONAL INSTITUTE OF MENTAL 1346 00:48:27,738 --> 00:48:28,572 HEALTH AND THE INDIVIDUALS AND 1347 00:48:28,639 --> 00:48:29,873 THEIR FAMILIES THAT STRUGGLE 1348 00:48:29,940 --> 00:48:31,475 EVERY DAY WITH MENTAL ILLNESS. 1349 00:48:31,541 --> 00:48:32,075 WE ARE GRATEFUL. 1350 00:48:32,142 --> 00:48:34,544 THANK YOU. 1351 00:48:34,611 --> 00:48:35,512 >> THANK YOU, TED. 1352 00:48:35,579 --> 00:48:37,281 >> AND TO SEE ALL THAT HAS 1353 00:48:37,347 --> 00:48:38,415 HAPPENED, I'LL JUST TAKE A 1354 00:48:38,482 --> 00:48:40,050 MINUTE TO HIGHLIGHT THAT FROM 1355 00:48:40,117 --> 00:48:41,685 COMPUTATIONAL PSYCHIATRY TO 1356 00:48:41,752 --> 00:48:42,786 PRECISIONAL PSYCHIATRY TO 1357 00:48:42,853 --> 00:48:44,254 ADVANCES IN SUICIDE TO 1358 00:48:44,321 --> 00:48:45,322 UNDERSTANDING MORE ASPECTS OF 1359 00:48:45,389 --> 00:48:47,424 THE GENETIC BASIS OF DISEASE, TO 1360 00:48:47,491 --> 00:48:50,527 THERAPEUTIC APPROACHES THAT YOU 1361 00:48:50,594 --> 00:48:51,061 DESCRIBED. 1362 00:48:51,128 --> 00:48:52,362 I REMEMBER BEING IN ROOMS, 1363 00:48:52,429 --> 00:48:55,198 ARGUING ABOUT FACE-SELECTIVE 1364 00:48:55,265 --> 00:48:56,767 NEURONS AT NIMH, IN FACT, SO 1365 00:48:56,833 --> 00:48:57,868 IT'S SO STRIKING TO SEE THIS 1366 00:48:57,934 --> 00:48:58,402 HAPPEN. 1367 00:48:58,468 --> 00:49:01,338 BUT WHAT IS PROBABLY MOST 1368 00:49:01,405 --> 00:49:02,506 DRAMATIC, REALLY, IS KIND OF 1369 00:49:02,572 --> 00:49:06,243 HIDDEN IN A PHOTO AT THE 1370 00:49:06,310 --> 00:49:07,344 INTERAGENCY AUTISM COORDINATING 1371 00:49:07,411 --> 00:49:09,946 COMMITTEE MEETING. 1372 00:49:10,013 --> 00:49:13,050 AND THAT IS THE WORD 1373 00:49:13,116 --> 00:49:13,717 "ACCEPTANCE" AFTER AUTISM. 1374 00:49:13,784 --> 00:49:15,786 IT'S CHANGED FROM AUTISM 1375 00:49:15,852 --> 00:49:16,853 AWARENESS TO AUTISM ACCEPTANCE, 1376 00:49:16,920 --> 00:49:18,355 AND I HOPE THAT THAT CAN HAPPEN 1377 00:49:18,422 --> 00:49:19,990 FOR ALL OF MENTAL ILLNESS, THAT 1378 00:49:20,057 --> 00:49:21,858 IT BECOMES SCHIZOPHRENIA 1379 00:49:21,925 --> 00:49:23,860 ACCEPTANCE AND BIPOLAR 1380 00:49:23,927 --> 00:49:25,195 ACCEPTANCE, MUCH MORE BROADLY. 1381 00:49:25,262 --> 00:49:28,031 THAT IS A REALLY, REALLY HUGE 1382 00:49:28,098 --> 00:49:28,899 IMPACT THAT CHANGES THE WAY 1383 00:49:28,965 --> 00:49:30,567 PEOPLE ARE ABLE TO BE INVOLVED 1384 00:49:30,634 --> 00:49:31,802 IN SOCIETY. 1385 00:49:31,868 --> 00:49:35,205 SO THANKS SO MUCH. 1386 00:49:35,272 --> 00:49:36,173 >> THANK YOU, TED. 1387 00:49:36,239 --> 00:49:45,849 APPRECIATE IT. 1388 00:49:45,916 --> 00:49:48,251 >> QUITE A GROUP THIS MORNING. 1389 00:49:48,318 --> 00:49:48,518 AFTERNOON. 1390 00:49:48,585 --> 00:49:50,520 IT AFTERNOON. 1391 00:49:50,587 --> 00:49:51,088 QUIET GROUP. 1392 00:49:51,154 --> 00:49:53,957 PLEASE. 1393 00:49:54,024 --> 00:50:00,330 >> I WON'T REPEAT WHAT TED SAID, 1394 00:50:00,397 --> 00:50:00,797 ELEGANTLY SAID. 1395 00:50:00,864 --> 00:50:01,865 SO I'LL JUST ASK A QUESTION. 1396 00:50:01,932 --> 00:50:06,737 I WAS REALLY IMPRESSED BY ALL OF 1397 00:50:06,803 --> 00:50:11,308 THE WORK THAT WILL BE COMING OUT 1398 00:50:11,375 --> 00:50:12,943 AND NIMH'S EFFORTS TO ASK THE 1399 00:50:13,009 --> 00:50:14,211 COMMUNITY WHAT THEY THINK ABOUT 1400 00:50:14,277 --> 00:50:15,445 VARIOUS THINGS, INCLUDING RACISM 1401 00:50:15,512 --> 00:50:17,247 AND ITS IMPACT ON HEALTH, THAT 1402 00:50:17,314 --> 00:50:20,016 WAS REALLY EXCITING. 1403 00:50:20,083 --> 00:50:21,385 ONE OF THE THINGS YOU'VE SHARED, 1404 00:50:21,451 --> 00:50:22,719 JOSH, WAS ALSO LOOKING AT MENTAL 1405 00:50:22,786 --> 00:50:25,055 HEALTH SERVICES RESEARCH. 1406 00:50:25,122 --> 00:50:26,523 AND REALLY TRYING TO UNDERSTAND 1407 00:50:26,590 --> 00:50:26,723 THAT. 1408 00:50:26,790 --> 00:50:29,393 AND IT MADE ME CURIOUS ABOUT 1409 00:50:29,459 --> 00:50:31,027 WHAT PERCENTAGE OF THE CURRENT 1410 00:50:31,094 --> 00:50:32,496 NIMH PORTFOLIO IS ON MENTAL 1411 00:50:32,562 --> 00:50:33,497 HEALTH SERVICES RESEARCH. 1412 00:50:33,563 --> 00:50:37,634 >> THAT'S A GOOD QUESTION. 1413 00:50:37,701 --> 00:50:39,803 I'M LOOKING AROUND TO SEE IF 1414 00:50:39,870 --> 00:50:40,804 JOEL OR PAT ARE THERE. 1415 00:50:40,871 --> 00:50:42,739 I DON'T REMEMBER THE MOST RECENT 1416 00:50:42,806 --> 00:50:45,375 NUMBERS FOR THE DIVISION OF 1417 00:50:45,442 --> 00:50:46,143 SERVICE INTERVENTION RESEARCH IN 1418 00:50:46,209 --> 00:50:47,110 TERMS OF THE PERCENTAGE. 1419 00:50:47,177 --> 00:50:50,881 THAT'S NOT ONLY -- IT CAN BE A 1420 00:50:50,947 --> 00:50:51,782 NUMBER OF DIFFERENT THINGS. 1421 00:50:51,848 --> 00:50:53,183 I'LL HAVE TO GET BACK TO YOU ON 1422 00:50:53,250 --> 00:50:54,618 THAT UNLESS ANYONE CAN POP UP 1423 00:50:54,684 --> 00:50:57,854 AND SAY. 1424 00:50:57,921 --> 00:50:59,156 FROM TIME TO TIME, I HAD 1425 00:50:59,222 --> 00:51:01,124 PROVIDED UPDATES ON THE 1426 00:51:01,191 --> 00:51:02,225 PERCENTAGE THAT GOES TO MORE 1427 00:51:02,292 --> 00:51:04,227 NEAR TERM RESEARCH THAT'S 1428 00:51:04,294 --> 00:51:06,863 INTERVENTION AND SERVICES FOCUS 1429 00:51:06,930 --> 00:51:07,564 COLLECTIVELY, BUT I THINK THE 1430 00:51:07,631 --> 00:51:08,932 LAST TIME I DID THAT WAS ABOUT 1431 00:51:08,999 --> 00:51:10,200 TWO YEARS AGO, SO WE COULD USE 1432 00:51:10,267 --> 00:51:13,904 AN UPDATE THERE AS WELL. 1433 00:51:13,970 --> 00:51:17,874 WE CAN GET THAT OUT TO YOU. 1434 00:51:17,941 --> 00:51:21,077 >> I WOULD SECOND THAT, 1435 00:51:21,144 --> 00:51:22,612 ESPECIALLY IT WAS VERY 1436 00:51:22,679 --> 00:51:23,346 INSIGHTFUL TO SEE WHAT THE 1437 00:51:23,413 --> 00:51:25,282 POLICY MAKERS ARE ASKING ABOUT 1438 00:51:25,348 --> 00:51:28,985 AND THINKING -- I'M GUESSING THE 1439 00:51:29,052 --> 00:51:30,086 PORTFOLIO IS MAYBE SMALLER THAN 1440 00:51:30,153 --> 00:51:31,288 SOME OF THE OTHER AREAS AND 1441 00:51:31,354 --> 00:51:33,323 THINKING ABOUT HOW TO GROW THAT, 1442 00:51:33,390 --> 00:51:34,391 ESPECIALLY SINCE IT'S SO 1443 00:51:34,458 --> 00:51:37,794 IMPORTANT AND IMPACTFUL FROM A 1444 00:51:37,861 --> 00:51:38,728 SOCIETAL PERSPECTIVE, SO I WOULD 1445 00:51:38,795 --> 00:51:39,496 LOVE TO SEE THAT. 1446 00:51:39,563 --> 00:51:40,497 >> THAT'S ONE OF THE THINGS THAT 1447 00:51:40,564 --> 00:51:43,433 I'VE COMMENTED ON IN THOSE 1448 00:51:43,500 --> 00:51:46,436 BLOGS, AND THAT WE HAVE FOCUSED 1449 00:51:46,503 --> 00:51:47,304 TREMENDOUSLY ON. 1450 00:51:47,370 --> 00:51:50,273 AND WE'VE BEEN BARELY SUCCESSFUL 1451 00:51:50,340 --> 00:51:52,943 AT INCREASING THE NUMBER OF 1452 00:51:53,009 --> 00:51:54,678 APPLICATIONS INTO DESR AND, 1453 00:51:54,744 --> 00:51:55,879 THEREFORE, INCREASING THE 1454 00:51:55,946 --> 00:51:56,980 DOLLARS THAT WE'RE SPENDING ON 1455 00:51:57,047 --> 00:51:57,714 IT. 1456 00:51:57,781 --> 00:52:03,186 BUT AS YOU MAY KNOW, RINAD, 1457 00:52:03,253 --> 00:52:05,188 PRIOR TO MY COMING, THERE WAS A 1458 00:52:05,255 --> 00:52:05,822 SUBSTANTIAL DECREASE OVER TIME 1459 00:52:05,889 --> 00:52:06,823 IN THAT PART OF THE PORTFOLIO, 1460 00:52:06,890 --> 00:52:09,659 AND WHAT I WOULD SAY IS FROM 1461 00:52:09,726 --> 00:52:11,161 THE -- JUST THINKING ABOUT THE 1462 00:52:11,228 --> 00:52:12,162 DATA THAT I PRESENTED A COUPLE 1463 00:52:12,229 --> 00:52:14,297 YEARS AGO, WE'RE BACK TO WHERE 1464 00:52:14,364 --> 00:52:16,166 WE WERE MORE OR LESS, BUT WHAT I 1465 00:52:16,233 --> 00:52:17,334 DON'T KNOW IS LIKE HOW MUCH OF 1466 00:52:17,400 --> 00:52:19,603 THAT IS REALLY IN THE SERVICES 1467 00:52:19,669 --> 00:52:21,805 REALM, HOW MUCH OF IT IS IN 1468 00:52:21,872 --> 00:52:23,640 IMPLEMENTATION RESEARCH, FOR 1469 00:52:23,707 --> 00:52:27,377 EXAMPLE, RINAUD, AND HOW MUCH IS 1470 00:52:27,444 --> 00:52:29,613 IN THE SORT OF MORE ADVANCED 1471 00:52:29,679 --> 00:52:30,747 STAGES OF CLINICAL TRIALS WHICH 1472 00:52:30,814 --> 00:52:32,516 ARE ALSO INCLUDED IN THOSE 1473 00:52:32,582 --> 00:52:40,156 NUMBERS. 1474 00:52:40,223 --> 00:52:40,390 PAMELA. 1475 00:52:40,457 --> 00:52:42,192 >> I ALSO WANT TO ECHO TED'S 1476 00:52:42,259 --> 00:52:43,493 THANKS FOR YOUR SERVICE, JOSH. 1477 00:52:43,560 --> 00:52:44,361 APPRECIATE THE WAY THAT YOU'VE 1478 00:52:44,427 --> 00:52:46,897 ALSO HIGHLIGHTED WORKFORCE 1479 00:52:46,963 --> 00:52:49,266 DIVERSITY AND MADE IT A POINT TO 1480 00:52:49,332 --> 00:52:52,202 REALLY TRY AND BE TRANSPARENT 1481 00:52:52,269 --> 00:52:53,937 ABOUT THAT WITH THE COUNCIL. 1482 00:52:54,004 --> 00:52:57,140 I HAVE A QUESTION ABOUT THE 1483 00:52:57,207 --> 00:52:58,408 75 MILLION INCREASE TO NIMH, AND 1484 00:52:58,475 --> 00:53:02,345 JUST WANTED TO HEAR A FEW MORE 1485 00:53:02,412 --> 00:53:05,348 DETAILS IF THESE ARE THINGS THAT 1486 00:53:05,415 --> 00:53:06,082 HAVE ALREADY BEEN FUNDED THAT 1487 00:53:06,149 --> 00:53:06,850 YOU CAN TALK ABOUT. 1488 00:53:06,917 --> 00:53:10,287 CAN YOU TELL US MORE ABOUT THE 1489 00:53:10,353 --> 00:53:11,621 LEARNING HEALTHCARE AND 1490 00:53:11,688 --> 00:53:14,024 PRIORITIES THAT HAVE COME OUT OF 1491 00:53:14,090 --> 00:53:14,424 THAT $75 MILLION? 1492 00:53:14,491 --> 00:53:15,825 >> LET ME SAY THIS THIS YEAR, 1493 00:53:15,892 --> 00:53:18,228 THE BULK OF THOSE $75 MILLION 1494 00:53:18,295 --> 00:53:19,763 WENT TO THE PRECISION PSYCHIATRY 1495 00:53:19,829 --> 00:53:20,864 INITIATIVES. 1496 00:53:20,931 --> 00:53:24,868 WHICH WE HAD LAUNCHED. 1497 00:53:24,935 --> 00:53:26,102 WITH SMALLER AMOUNTS GOING TO 1498 00:53:26,169 --> 00:53:28,705 THE TWO AREAS THAT YOU 1499 00:53:28,772 --> 00:53:30,106 IDENTIFIED AS WELL AS THE FOURTH 1500 00:53:30,173 --> 00:53:33,443 AREA, WHICH IS IN DIVERSIFYING 1501 00:53:33,510 --> 00:53:33,777 GENETICS. 1502 00:53:33,843 --> 00:53:35,145 SO LET ME START THERE REALLY 1503 00:53:35,211 --> 00:53:37,013 QUICKLY. 1504 00:53:37,080 --> 00:53:39,215 IN THAT REGARD, WE HAVE FUNDED A 1505 00:53:39,282 --> 00:53:41,484 NUMBER OF GRANTS IN THE 1506 00:53:41,551 --> 00:53:43,420 ANCESTRAL -- DIVERSE ANCESTRAL 1507 00:53:43,486 --> 00:53:44,054 POPULATIONS NETWORK, AS WELL AS 1508 00:53:44,120 --> 00:53:45,622 SOME OTHER EFFORTS TO MOVE FROM 1509 00:53:45,689 --> 00:53:48,358 GENES INTO BIOLOGY. 1510 00:53:48,425 --> 00:53:49,960 USING THAT 1511 00:53:50,026 --> 00:53:50,160 DATA. 1512 00:53:50,226 --> 00:53:51,461 AND THEN IN PRECISION 1513 00:53:51,528 --> 00:53:53,630 PSYCHIATRY, OF COURSE, WE FUNDED 1514 00:53:53,697 --> 00:53:56,199 THE IMPACT INITIATIVE AND THE 1515 00:53:56,266 --> 00:53:56,866 INNOVATION FUNNEL WHICH WILL BE 1516 00:53:56,933 --> 00:53:57,734 COMING TO YOU TOMORROW. 1517 00:53:57,801 --> 00:53:59,436 THAT'S ALL PART OF THE 1518 00:53:59,502 --> 00:53:59,736 $75 MILLION. 1519 00:53:59,803 --> 00:54:01,171 IN THE LEARNING HEALTHCARE 1520 00:54:01,237 --> 00:54:04,240 NETWORK AREA, WE WERE ABLE TO -- 1521 00:54:04,307 --> 00:54:05,775 ALTHOUGH WE HADN'T FINALIZED IT 1522 00:54:05,842 --> 00:54:06,977 BECAUSE WE'RE WAITING FOR THOSE 1523 00:54:07,043 --> 00:54:08,111 GRANTS TO BE -- THEY WILL COME 1524 00:54:08,178 --> 00:54:10,313 TO YOU IN A RAPID AUGUST 1525 00:54:10,380 --> 00:54:12,382 COUNCIL, WE HAVE SEVERAL 1526 00:54:12,449 --> 00:54:14,084 RENEWALS OF THE EPINET PROGRAM 1527 00:54:14,150 --> 00:54:15,852 WHICH WE'RE GOING TO MOVE, IF WE 1528 00:54:15,919 --> 00:54:17,721 CAN, MOVE FORWARD TO FUND IN 1529 00:54:17,787 --> 00:54:19,022 THIS FISCAL YEAR. 1530 00:54:19,089 --> 00:54:20,490 AS WELL AS ADDITIONAL ONES THAT 1531 00:54:20,557 --> 00:54:22,792 WE WILL FUND IN NEXT FISCAL YEAR 1532 00:54:22,859 --> 00:54:23,660 ANTICIPATING THAT THE BUDGET 1533 00:54:23,727 --> 00:54:25,795 WILL BE AT LEAST STABLE AND 1534 00:54:25,862 --> 00:54:26,997 WE'LL BE ABLE TO DO THAT NEXT 1535 00:54:27,063 --> 00:54:30,600 YEAR. 1536 00:54:30,667 --> 00:54:31,801 THEN ALSO IN LEARNING 1537 00:54:31,868 --> 00:54:32,636 HEALTHCARE, WE ARE DEVELOPING 1538 00:54:32,702 --> 00:54:35,372 PLANS TO EXPAND BEYOND EPINET 1539 00:54:35,438 --> 00:54:36,272 INTO OTHER AREAS. 1540 00:54:36,339 --> 00:54:38,441 I CAN'T TALK ABOUT THOSE 1541 00:54:38,508 --> 00:54:39,709 DETAILS -- THAT'S NOT PUBLISHED 1542 00:54:39,776 --> 00:54:40,143 YET, RIGHT? 1543 00:54:40,210 --> 00:54:41,277 I WON'T TALK ABOUT THE DETAILS, 1544 00:54:41,344 --> 00:54:42,479 BUT I WOULD SAY THAT PART OF THE 1545 00:54:42,545 --> 00:54:44,581 PLAN IS TO EXPAND BEYOND JUST 1546 00:54:44,648 --> 00:54:45,048 EPINET. 1547 00:54:45,115 --> 00:54:47,017 BUT THAT'S NOT THIS FISCAL YEAR. 1548 00:54:47,083 --> 00:54:48,852 IN YOUTH MENTAL HEALTH, THERE'S 1549 00:54:48,918 --> 00:54:52,756 BEEN A NUMBER OF THE EFFORTS IN 1550 00:54:52,822 --> 00:54:54,591 SYSTEMS OF CARE THAT WE'VE 1551 00:54:54,658 --> 00:54:56,693 INVESTED IN YOUTH MENTAL HEALTH 1552 00:54:56,760 --> 00:54:58,228 IN GENERAL THAT WE DON'T HAVE A 1553 00:54:58,294 --> 00:54:59,462 SPECIFIC INITIATIVE IT IS TIED 1554 00:54:59,529 --> 00:55:01,097 TO, AND THEN ALSO COMING TO YOU 1555 00:55:01,164 --> 00:55:02,632 IN THE AUGUST COUNCIL WILL BE 1556 00:55:02,699 --> 00:55:04,534 THE RESULTS OF A REISSUE OF THE 1557 00:55:04,601 --> 00:55:06,970 YOUTH AND SOCIAL MEDIA, WHICH 1558 00:55:07,037 --> 00:55:08,938 WAS SPECIFICALLY CALLED OUT FOR 1559 00:55:09,005 --> 00:55:10,674 SUPPORT AGAIN BY CONGRESS, 1560 00:55:10,740 --> 00:55:11,741 ALTHOUGH NO SPECIFIC DOLLAR 1561 00:55:11,808 --> 00:55:13,176 AMOUNT THIS YEAR WAS 1562 00:55:13,243 --> 00:55:17,213 APPROPRIATED TO IT. 1563 00:55:17,280 --> 00:55:18,314 SO THOSE ARE THE AREAS WE'RE 1564 00:55:18,381 --> 00:55:19,549 ACTIVE IN AND WE'RE PLANNING A 1565 00:55:19,616 --> 00:55:20,550 NUMBER OF DIFFERENT INITIATIVES 1566 00:55:20,617 --> 00:55:22,185 IN THAT YOUTH MENTAL HEALTH AND 1567 00:55:22,252 --> 00:55:22,819 LEARNING HEALTHCARE SPACE OVER 1568 00:55:22,886 --> 00:55:29,893 THE NEXT COUPLE OF YEARS. 1569 00:55:29,959 --> 00:55:30,126 ANGUS. 1570 00:55:30,193 --> 00:55:31,561 IS THERE ONE ONLINE? 1571 00:55:31,628 --> 00:55:33,063 SORRY? 1572 00:55:33,129 --> 00:55:34,397 OKAY, GREAT. 1573 00:55:34,464 --> 00:55:35,865 LET'S GO WITH ANITA AND COME 1574 00:55:35,932 --> 00:55:37,534 BACK TO ANGUS. 1575 00:55:37,600 --> 00:55:40,570 >> SO THANK YOU, DR. GORDON, AND 1576 00:55:40,637 --> 00:55:42,405 I ALSO WANT TO SHARE MY SORROW 1577 00:55:42,472 --> 00:55:43,406 THAT YOU'RE LEAVING BUT ALSO JOY 1578 00:55:43,473 --> 00:55:44,808 FOR YOU WITH WHERE YOU'LL BE 1579 00:55:44,874 --> 00:55:45,809 GOING. 1580 00:55:45,875 --> 00:55:47,477 I DID JUST WANT TO ADD FOR THOSE 1581 00:55:47,544 --> 00:55:48,845 WHO ARE INTERESTED IN THE 1582 00:55:48,912 --> 00:55:51,815 SERVICES COMPONENT THAT WE'VE 1583 00:55:51,881 --> 00:55:54,017 BEEN WORKING ON A COUPLE OF 1584 00:55:54,084 --> 00:55:56,119 NOSIs THAT CONNECT OUR GRANTS 1585 00:55:56,186 --> 00:55:58,088 WHICH ARE SERVICES-RELATED TO 1586 00:55:58,154 --> 00:55:59,856 RESEARCH OPPORTUNITIES. 1587 00:55:59,923 --> 00:56:02,192 SO WE'RE HOPEFUL THAT WILL GROW. 1588 00:56:02,258 --> 00:56:03,727 AND JUST WANT TO LET YOU KNOW 1589 00:56:03,793 --> 00:56:05,462 THAT THAT'S BEEN A SUPPORTED WAY 1590 00:56:05,528 --> 00:56:08,465 OR ACTUALLY BRING TO FRUITION 1591 00:56:08,531 --> 00:56:10,233 THAT CLOSE ENING OF 1592 00:56:10,300 --> 00:56:11,000 OPPORTUNITIES WE MIGHT HAVE 1593 00:56:11,067 --> 00:56:12,335 THROUGH OUR SERVICES GRANTS TO 1594 00:56:12,402 --> 00:56:13,436 ANSWER IMPORTANT RESEARCH 1595 00:56:13,503 --> 00:56:16,539 QUESTIONS IN THE SERVICES AREA. 1596 00:56:16,606 --> 00:56:19,709 >> COLLABORATION WITH SAMHSA 1597 00:56:19,776 --> 00:56:21,044 BEGINNING WITH EP EE NET AND 1598 00:56:21,111 --> 00:56:22,345 MOVING INTO OTHER AREAS 1599 00:56:22,412 --> 00:56:23,613 INCLUDING THE WORK THAT ANITA 1600 00:56:23,680 --> 00:56:26,850 ALLUDED TO IS REALLY HELPING 1601 00:56:26,916 --> 00:56:29,452 BUILD THAT PROGRAM IN GENERAL. 1602 00:56:29,519 --> 00:56:31,755 ANGUS. 1603 00:56:31,821 --> 00:56:33,656 >> ACTUALLY THAT WAS QUITE 1604 00:56:33,723 --> 00:56:34,524 TIMELY BECAUSE ONE OF MY 1605 00:56:34,591 --> 00:56:36,493 QUESTIONS WAS ABOUT 1606 00:56:36,559 --> 00:56:38,695 COLLABORATION WITH SAMHSA. 1607 00:56:38,762 --> 00:56:39,729 BUT FIRST I WANTED TO JUST 1608 00:56:39,796 --> 00:56:41,064 MENTION, I REMEMBER WHEN YOU 1609 00:56:41,131 --> 00:56:44,234 WERE APPOINTED AND WE WERE LIKE, 1610 00:56:44,300 --> 00:56:48,905 WAIT, THE JOSH -- IS THAT OUR 1611 00:56:48,972 --> 00:56:49,439 JOSH GORDON? 1612 00:56:49,506 --> 00:56:50,740 HE'S SO DOWN TO EARTH. 1613 00:56:50,807 --> 00:56:51,841 WHAT'S GOING TO HAPPEN WHEN HE 1614 00:56:51,908 --> 00:56:55,678 SHIPS OFF TO WASHINGTON AND -- I 1615 00:56:55,745 --> 00:56:58,715 WANT TO ADMIRE THAT YOU HAVE 1616 00:56:58,782 --> 00:57:01,951 BROUGHT THAT DOWN TO EARTH TO 1617 00:57:02,018 --> 00:57:03,386 THIS POSITION, AND I THINK IT'S 1618 00:57:03,453 --> 00:57:05,054 BEEN TO THE BENEFIT OF THE 1619 00:57:05,121 --> 00:57:05,855 RESEARCH IN THIS AREA, IT'S BEEN 1620 00:57:05,922 --> 00:57:10,994 TO THE BENEFIT OF THE INSTITUTE, 1621 00:57:11,060 --> 00:57:16,132 AND SO YOU LEAVE WITH SOME OF 1622 00:57:16,199 --> 00:57:19,602 THAT SAME DOWN TO EARTH AND 1623 00:57:19,669 --> 00:57:21,004 HAVING BROUGHT ALL OF THAT 1624 00:57:21,070 --> 00:57:24,407 SCIENTIFIC SENSIBILITY THAT YOU 1625 00:57:24,474 --> 00:57:27,076 HAD AT THE TIME AND DEPLOYED IT 1626 00:57:27,143 --> 00:57:27,677 BROADLY ACROSS MENTAL HEALTH 1627 00:57:27,744 --> 00:57:31,281 RESEARCH. 1628 00:57:31,347 --> 00:57:33,750 SO VERY -- YOU'RE GOING TO BE 1629 00:57:33,817 --> 00:57:34,083 MISSED. 1630 00:57:34,150 --> 00:57:36,586 YOU'RE GOING TO LEAVE SOME BIG 1631 00:57:36,653 --> 00:57:42,592 SHOES HERE. 1632 00:57:42,659 --> 00:57:43,660 IN TERMS OF SUBSTANTIVE 1633 00:57:43,726 --> 00:57:44,861 QUESTIONS, NOW I GET TO TURN UP 1634 00:57:44,928 --> 00:57:51,000 THE HEAT, THE CAPACITY TO HAVE A 1635 00:57:51,067 --> 00:57:52,902 BUDGET RISE IN THIS ENVIRONMENT 1636 00:57:52,969 --> 00:57:58,808 IS TOTALLY NON-TRIVIAL. 1637 00:57:58,875 --> 00:58:01,544 AND SO I GUESS ONE OF MY 1638 00:58:01,611 --> 00:58:06,082 QUESTIONS WAS, DID SAMHSA GET 1639 00:58:06,149 --> 00:58:12,021 SIMILAR LO LOVE AND HOW ARE THOE 1640 00:58:12,088 --> 00:58:12,755 INITIATIVES COMING TOGETHER, 1641 00:58:12,822 --> 00:58:15,558 WHAT I DOES THE TOTAL PICTURE LK 1642 00:58:15,625 --> 00:58:19,629 LIKE IN TERMS OF INCREASES IN 1643 00:58:19,696 --> 00:58:20,930 THE CAPACITY FOR SERVICE, AND 1644 00:58:20,997 --> 00:58:24,500 ALSO HOW DOES THAT IMPACT A 1645 00:58:24,567 --> 00:58:26,803 NUMBER OF THE BROADER TRENDS 1646 00:58:26,870 --> 00:58:30,740 THAT ARE IN BIOMEDICAL 1647 00:58:30,807 --> 00:58:32,809 PSYCHIATRIC RESEARCH DOMAINS 1648 00:58:32,876 --> 00:58:36,713 SUCH AS INCREASES IN SALARIES 1649 00:58:36,779 --> 00:58:44,020 FOR POSTDOCS, A LEVEL -- IS 1650 00:58:44,087 --> 00:58:47,624 THERE DISCUSSION OF CHANGING 1651 00:58:47,690 --> 00:58:48,992 CAPS, SO ON AND SO FORTH, WHICH 1652 00:58:49,058 --> 00:58:50,526 NOW ARE BECOMING SORT OF THE 1653 00:58:50,593 --> 00:58:54,163 NORM, YOU KNOW, THOSE HAVEN'T 1654 00:58:54,230 --> 00:58:56,165 BEEN TOUCHED IN THE CONTEXT OF 1655 00:58:56,232 --> 00:59:00,036 INFLATION. 1656 00:59:00,103 --> 00:59:01,471 HOW IS THE BROADER INSTITUTE 1657 00:59:01,537 --> 00:59:02,772 THINKING ABOUT THOSE HOUSED IN 1658 00:59:02,839 --> 00:59:04,307 NIH THINKING ABOUT THIS? 1659 00:59:04,374 --> 00:59:06,142 >> OKAY. 1660 00:59:06,209 --> 00:59:07,110 FIRST, THANK YOU FOR THOSE 1661 00:59:07,176 --> 00:59:08,111 QUESTIONS, THANK YOU FOR YOUR 1662 00:59:08,177 --> 00:59:08,544 REMARKS. 1663 00:59:08,611 --> 00:59:13,249 I'M GOING TO CREDIT MY DOWN TO 1664 00:59:13,316 --> 00:59:14,317 EARTHINESS THE TWO YEARS I SPENT 1665 00:59:14,384 --> 00:59:16,219 WHEN I WAS 9 AND 10 LIVING IN 1666 00:59:16,286 --> 00:59:16,486 MINNESOTA. 1667 00:59:16,552 --> 00:59:17,453 THOSE OF YOU THAT DON'T KNOW, 1668 00:59:17,520 --> 00:59:20,523 THAT'S WHERE ANGUS IS. 1669 00:59:20,590 --> 00:59:22,058 OKAY. 1670 00:59:22,125 --> 00:59:24,027 NOW SAMHSA, I DON'T KNOW WHAT 1671 00:59:24,093 --> 00:59:25,628 SAMHSA'S BUDGET WAS IN 2024, BUT 1672 00:59:25,695 --> 00:59:27,697 AS MOST OF YOU KNOW, SAMHSA'S 1673 00:59:27,764 --> 00:59:28,898 BUDGET HAS DRAMATICALLY 1674 00:59:28,965 --> 00:59:29,933 INCREASED IN THE LAST SEVERAL 1675 00:59:29,999 --> 00:59:32,168 YEARS SINCE THE PANDEMIC WITH 1676 00:59:32,235 --> 00:59:33,469 INCREASING RECOGNITION OF THE 1677 00:59:33,536 --> 00:59:35,104 NEED FOR MENTAL HEALTH SERVICES. 1678 00:59:35,171 --> 00:59:36,139 ONE OF THE RESULTS OF THAT IS 1679 00:59:36,205 --> 00:59:38,841 EXPANSION OF CERTIFIED COMMUNITY 1680 00:59:38,908 --> 00:59:40,310 BEHAVIORAL HEALTH CENTERS, WHICH 1681 00:59:40,376 --> 00:59:41,144 REPRESENTS AN OPPORTUNITY 1682 00:59:41,210 --> 00:59:42,345 WHETHER THEY WENT UP AGAIN THIS 1683 00:59:42,412 --> 00:59:44,847 YEAR OR NOT FOR US TO ACCESS 1684 00:59:44,914 --> 00:59:46,616 THAT IN TERMS OF COMMUNITY-BASED 1685 00:59:46,683 --> 00:59:50,219 RESEARCH. 1686 00:59:50,286 --> 00:59:52,355 SO THE COLLABORATIONS THAT WE'RE 1687 00:59:52,422 --> 00:59:53,790 TALKING ABOUT AREN'T NECESSARILY 1688 00:59:53,856 --> 00:59:55,091 DEPENDENT UPON INCREASES IN 1689 00:59:55,158 --> 00:59:56,559 SAMHSA'S BUDGET, BECAUSE WHAT 1690 00:59:56,626 --> 00:59:57,560 WE'RE TRYING TO DO IS FIGURE OUT 1691 00:59:57,627 --> 01:00:01,397 WAYS THAT RESEARCHERS CAN TAP 1692 01:00:01,464 --> 01:00:02,432 INTO THAT NETWORK AND CONTRIBUTE 1693 01:00:02,498 --> 01:00:06,936 TO THE EFFICIENT AND EFFECTIVE 1694 01:00:07,003 --> 01:00:07,770 OPERATION OF THE CLINICAL 1695 01:00:07,837 --> 01:00:09,639 SERVICES THAT SAMHSA PROVIDES 1696 01:00:09,706 --> 01:00:11,174 THROUGH COLLABORATIONAL 1697 01:00:11,240 --> 01:00:11,507 RESEARCH. 1698 01:00:11,574 --> 01:00:13,776 SO IT'S NOT NECESSARILY DEPEND 1699 01:00:13,843 --> 01:00:16,913 DDEPENDENT UPON INCREASES THERE. 1700 01:00:16,980 --> 01:00:18,314 THE THIRD THING IS HOW DOES THE 1701 01:00:18,381 --> 01:00:19,749 BUDGET PICTURE, BOTH OUR MODEST 1702 01:00:19,816 --> 01:00:21,718 INCREASE AND THE OVERALL 1703 01:00:21,784 --> 01:00:23,453 LIKELIHOOD PERHAPS OF NOT SEEING 1704 01:00:23,519 --> 01:00:24,754 INCREASES IN THE NEAR FUTURE, 1705 01:00:24,821 --> 01:00:27,156 HOW DOES THAT AFFECT THINGS -- 1706 01:00:27,223 --> 01:00:30,660 THE GENERAL FUNDING PICTURE? 1707 01:00:30,727 --> 01:00:32,061 YOU MENTIONED A COUPLE OF 1708 01:00:32,128 --> 01:00:33,696 FACTORS, RIGHT, ONE OF WHICH WAS 1709 01:00:33,763 --> 01:00:36,099 THE INCREASE IN POSTDOCTORAL 1710 01:00:36,165 --> 01:00:36,366 SALARIES. 1711 01:00:36,432 --> 01:00:39,602 SO AS YOU KNOW, THE ADVISORY 1712 01:00:39,669 --> 01:00:40,670 COUNCIL OF THE DIRECTOR 1713 01:00:40,737 --> 01:00:42,939 RECOMMENDED TO THE NIH DIRECTOR 1714 01:00:43,006 --> 01:00:44,574 THAT POSTDOC SALARIES BE 1715 01:00:44,640 --> 01:00:47,043 INCREASED TO A MINIMUM OF 1716 01:00:47,110 --> 01:00:47,477 $70,000. 1717 01:00:47,543 --> 01:00:49,245 WE AS INSTITUTE DIRECTORS MET 1718 01:00:49,312 --> 01:00:50,880 WITH TOGETHER AND DISCUSSED WITH 1719 01:00:50,947 --> 01:00:52,382 THE INSTITUTE DIRECTOR AND MADE 1720 01:00:52,448 --> 01:00:53,349 A COLLECTIVE DECISION THAT THAT 1721 01:00:53,416 --> 01:00:55,218 IS OUR GOAL BUT WE CANNOT DO IT 1722 01:00:55,284 --> 01:00:56,185 OVERNIGHT, AND ONE OF THE 1723 01:00:56,252 --> 01:00:57,487 REASONS WHY WE CAN'T DO IT 1724 01:00:57,553 --> 01:00:58,354 OVERNIGHT IS BECAUSE OF THE 1725 01:00:58,421 --> 01:00:58,888 BUDGET PICTURE. 1726 01:00:58,955 --> 01:01:02,859 SO WE HAVE A PLAN TO GET TO 70K 1727 01:01:02,925 --> 01:01:03,893 OVER THE NEXT SEVERAL YEARS. 1728 01:01:03,960 --> 01:01:04,994 I DON'T REMEMBER IF IT'S TWO 1729 01:01:05,061 --> 01:01:06,162 YEARS OR FIVE YEARS, BUT IT'S 1730 01:01:06,229 --> 01:01:08,231 OVER THE NEXT SEVERAL YEARS AS A 1731 01:01:08,297 --> 01:01:09,899 MINIMUM POSTDOC SALARY. 1732 01:01:09,966 --> 01:01:11,734 WE COULD GET THERE FASTER IF THE 1733 01:01:11,801 --> 01:01:14,337 BUDGET WENT UP MORE BECAUSE IF 1734 01:01:14,404 --> 01:01:16,305 THE BUDGET DOESN'T GO UP THEN 1735 01:01:16,372 --> 01:01:17,840 HAVING HIGHER POSTDOC SALARIES 1736 01:01:17,907 --> 01:01:20,209 MEANS PAYING FEWER POSTDOCS, AND 1737 01:01:20,276 --> 01:01:22,945 THAT HAS ITS DISADVANTAGES. 1738 01:01:23,012 --> 01:01:24,013 NONETHELESS, WE'RE COMMITTED TO 1739 01:01:24,080 --> 01:01:25,081 INCREASING IT REGARDLESS OF THE 1740 01:01:25,148 --> 01:01:27,183 BUDGET PICTURE, SO IF THE BUDGET 1741 01:01:27,250 --> 01:01:28,718 PICTURE REMAINS STAGNANT, IT 1742 01:01:28,785 --> 01:01:30,353 DOES MEAN WE'LL HAVE FEWER 1743 01:01:30,420 --> 01:01:31,220 FELLOW SHIPS TO MORE 1744 01:01:31,287 --> 01:01:32,221 INDIVIDUALS. 1745 01:01:32,288 --> 01:01:33,556 IT'S NOT A HUGE FIGHT IN TERMS 1746 01:01:33,623 --> 01:01:36,025 OF THE NUMBERS -- HUGE BITE. 1747 01:01:36,092 --> 01:01:37,894 IT'S A MODEST DECREASE AT LEAST 1748 01:01:37,960 --> 01:01:39,829 IN THE NEXT YEAR OR TWO IN TERMS 1749 01:01:39,896 --> 01:01:41,130 OF THE NUMBER OF SLOTS IF WE 1750 01:01:41,197 --> 01:01:42,432 HAVE A STEADY BUDGET. 1751 01:01:42,498 --> 01:01:43,633 WHAT IT MEANS FOR NIMH TO HAVE 1752 01:01:43,699 --> 01:01:45,101 HAD A MODEST INCREASE THIS YEAR 1753 01:01:45,168 --> 01:01:47,403 IS THAT WE CAN ACTUALLY PROVIDE 1754 01:01:47,470 --> 01:01:49,705 THAT INCREASE AT LEAST THIS 1755 01:01:49,772 --> 01:01:50,406 YEAR'S INCREASE WITHOUT 1756 01:01:50,473 --> 01:01:52,075 DECREASING THE NUMBER OF SLOTS 1757 01:01:52,141 --> 01:01:52,642 WE FUND. 1758 01:01:52,708 --> 01:01:54,510 SO WE DO HAVE SOME MORE MONEY 1759 01:01:54,577 --> 01:01:57,113 THAT WE CAN ATTRIBUTE TO 1760 01:01:57,180 --> 01:01:59,082 TRAINING, NOT NECESSARILY 1761 01:01:59,148 --> 01:02:00,983 BECAUSE CONGRESS SAID TO SPEND 1762 01:02:01,050 --> 01:02:02,752 $75 MILLION ON IT, BUT BECAUSE 1763 01:02:02,819 --> 01:02:03,920 THAT CREATES A LITTLE MORE 1764 01:02:03,986 --> 01:02:05,154 FLEXIBILITY IN OUR OVERALL 1765 01:02:05,221 --> 01:02:05,421 BUDGET. 1766 01:02:05,488 --> 01:02:07,123 WHAT THE FUTURE -- WHERE THE 1767 01:02:07,190 --> 01:02:08,491 FUTURE LIES, I DO NOT KNOW. 1768 01:02:08,558 --> 01:02:10,159 BUT AGAIN, WE'VE COMMITTED TO 1769 01:02:10,226 --> 01:02:12,228 RAISING THE POSTDOC SALARY TO 1770 01:02:12,295 --> 01:02:14,964 THAT $70,000 MARK. 1771 01:02:15,031 --> 01:02:16,332 AND FOR THOSE OF WHO YOU ARE 1772 01:02:16,399 --> 01:02:18,634 INTERESTED, OF COURSE, GRAD 1773 01:02:18,701 --> 01:02:19,836 STUDENT STIPENDS HAVE BEEN 1774 01:02:19,902 --> 01:02:20,903 INCREASED AGAIN AND THEY WILL 1775 01:02:20,970 --> 01:02:22,338 CONTINUE TO INCREASE MODESTLY 1776 01:02:22,405 --> 01:02:23,940 EACH YEAR BUT WE DON'T HAVE A 1777 01:02:24,006 --> 01:02:24,707 PARTICULAR TARGET FIGURE FOR 1778 01:02:24,774 --> 01:02:27,243 THAT. 1779 01:02:27,310 --> 01:02:29,378 IN TERMS OF THE QUESTION ABOUT 1780 01:02:29,445 --> 01:02:31,447 MODULAR BUDGETS OR BUDGET CAPS 1781 01:02:31,514 --> 01:02:32,882 AND WHETHER THERE'S TALK OF 1782 01:02:32,949 --> 01:02:33,983 INCREASING THEM, I WOULD SAY THE 1783 01:02:34,050 --> 01:02:36,686 ANSWER IS STILL NO. 1784 01:02:36,752 --> 01:02:39,522 YES, I MEAN, YOU CAN LOOK 1785 01:02:39,589 --> 01:02:41,724 THROUGH YOUR GRANT LIST 1786 01:02:41,791 --> 01:02:43,059 TOMORROW, YOU WILL SEE VERY, 1787 01:02:43,126 --> 01:02:47,263 VERY, VERY FEW MODULAR BUDGETS 1788 01:02:47,330 --> 01:02:48,531 IN TOMORROW'S ALLOCATION. 1789 01:02:48,598 --> 01:02:50,766 IN FACT, I'M ALWAYS SURPRISED 1790 01:02:50,833 --> 01:02:52,034 WHEN ONE COMES ACROSS MY DESK. 1791 01:02:52,101 --> 01:02:53,236 I ONLY REMEMBER ONE OR TWO IN 1792 01:02:53,302 --> 01:02:54,103 THE GRANTS THAT WE HAD TO 1793 01:02:54,170 --> 01:02:57,039 DISCUSS. 1794 01:02:57,106 --> 01:02:58,641 SO THAT'S REALLY GONE AWAY. 1795 01:02:58,708 --> 01:02:59,909 THERE'S REALLY VERY FEW PEOPLE 1796 01:02:59,976 --> 01:03:00,877 THAT ARE SUBMITTING THAT. 1797 01:03:00,943 --> 01:03:02,178 SO REALLY THE NEXT QUESTION IS 1798 01:03:02,245 --> 01:03:03,679 DO WE WANT TO INSTITUTE A 1799 01:03:03,746 --> 01:03:05,114 MODULAR BUDGET, A HIGHER LEVEL, 1800 01:03:05,181 --> 01:03:06,849 AND WE HAVEN'T REALLY -- THERE'S 1801 01:03:06,916 --> 01:03:09,118 NOT A LOT OF ENTHUSIASM FOR 1802 01:03:09,185 --> 01:03:10,052 DOING THAT BECAUSE THE 1803 01:03:10,119 --> 01:03:11,621 PERCEPTION AT LEAST THAT WE HEAR 1804 01:03:11,687 --> 01:03:13,923 FROM OUR COMMUNITIES IS THAT THE 1805 01:03:13,990 --> 01:03:15,424 MODULAR BUDGET DOESN'T ACTUALLY 1806 01:03:15,491 --> 01:03:19,162 SAVE PIs OR INSTITUTIONS' 1807 01:03:19,228 --> 01:03:19,695 WORK. 1808 01:03:19,762 --> 01:03:26,235 IF WE THE NEXT QUESTION BECOMES, 1809 01:03:26,302 --> 01:03:28,471 ALL KINDS OF CAPS WE HAVE, THE 1810 01:03:28,538 --> 01:03:29,438 $500,000 CAP WHERE YOU HAVE TO 1811 01:03:29,505 --> 01:03:31,240 ASK US TO COME IN A GRANT HIGHER 1812 01:03:31,307 --> 01:03:32,942 THAN THAT. THE $2 MILLION TOTAL 1813 01:03:33,009 --> 01:03:35,144 COST THAT -- NOT CAP BUT 1814 01:03:35,211 --> 01:03:36,546 THRESHOLD FOR SENDING THINGS TO 1815 01:03:36,612 --> 01:03:38,414 CONGRESS. 1816 01:03:38,481 --> 01:03:39,682 THAT $2 MILLION WAS INCREASED, 1817 01:03:39,749 --> 01:03:41,450 IT USED TO BE LOWER, JUST 1818 01:03:41,517 --> 01:03:42,585 RECENTLY. 1819 01:03:42,652 --> 01:03:44,287 SO I DON'T SEE THAT CHANGING 1820 01:03:44,353 --> 01:03:46,322 MUCH, AND WE HAVEN'T HAD ANY 1821 01:03:46,389 --> 01:03:48,858 DISCUSSIONS ABOUT CHANGING THAT 1822 01:03:48,925 --> 01:03:51,027 $500,000 CAP. 1823 01:03:51,093 --> 01:03:52,895 IF THOSE THINGS ARE BECOMING 1824 01:03:52,962 --> 01:03:54,397 IMPEDIMENTS TO DESIGNING GOOD 1825 01:03:54,463 --> 01:03:56,699 RESEARCH, PLEASE GIVE US THAT 1826 01:03:56,766 --> 01:03:58,768 FEEDBACK, GIVE NIH, THE 1827 01:03:58,834 --> 01:03:59,902 DIRECTOR'S OFFICE THAT FEEDBACK, 1828 01:03:59,969 --> 01:04:01,170 AND WE CAN START HAVING THOSE 1829 01:04:01,237 --> 01:04:11,447 DISCUSSIONS. 1830 01:04:15,318 --> 01:04:18,087 >> I DON'T WANT TO REPEAT WHAT 1831 01:04:18,154 --> 01:04:19,755 WAS SAID BUT THANK YOU JOSH 1832 01:04:19,822 --> 01:04:21,390 GROWR BRIL YONT AND WELCOMED 1833 01:04:21,457 --> 01:04:23,025 LEADERSHIP OVER THE YEARS, 1834 01:04:23,092 --> 01:04:23,960 REALLY APPRECIATE YOUR WONDERFUL 1835 01:04:24,026 --> 01:04:24,360 SERVICE. 1836 01:04:24,427 --> 01:04:25,494 I WANTED TO COMMENT ON ONE OF 1837 01:04:25,561 --> 01:04:26,128 THE THINGS SEVERAL COLLEAGUES 1838 01:04:26,195 --> 01:04:27,563 HAVE MENTIONED AND THAT'S THE 1839 01:04:27,630 --> 01:04:30,633 INCREASED FUNDING IN SERVICES IN 1840 01:04:30,700 --> 01:04:32,001 INTERVENTIONAL RESEARCH, 1841 01:04:32,068 --> 01:04:33,436 BEHAVIORAL RESEARCH DURING YOUR 1842 01:04:33,502 --> 01:04:34,437 TENURE, ALSO WANT TO JOIN THE 1843 01:04:34,503 --> 01:04:35,571 COURSE OF PEOPLE ASKING FOR MORE 1844 01:04:35,638 --> 01:04:35,938 OF THIS. 1845 01:04:36,005 --> 01:04:37,373 THERE'S A WAY TO BUILD THIS IN, 1846 01:04:37,440 --> 01:04:38,474 HAVE IT BE PART OF THE SEARCH 1847 01:04:38,541 --> 01:04:40,376 FOR THE NEXT DIRECTOR, AND I 1848 01:04:40,443 --> 01:04:43,579 NOTE THAT OUR PRIOR DIRECTOR OF 1849 01:04:43,646 --> 01:04:44,880 NIMH SAID AFTER HE STEPPED DOWN 1850 01:04:44,947 --> 01:04:46,082 AFTER BRILLIANT LEADERSHIP AS 1851 01:04:46,148 --> 01:04:48,484 WELL, REALLY SHOULD HAVE 1852 01:04:48,551 --> 01:04:49,685 INVESTED MORE IN BEHAVIORAL 1853 01:04:49,752 --> 01:04:50,653 RESEARCH. 1854 01:04:50,720 --> 01:04:52,955 OUR FORMER NIH DIRECTOR SAID 1855 01:04:53,022 --> 01:04:55,424 THIS PAST WEEK, COVID, SHOULD 1856 01:04:55,491 --> 01:04:57,727 HAVE FOCUSED MORE ON BEHAVIORAL 1857 01:04:57,793 --> 01:04:58,160 RESEARCH. 1858 01:04:58,227 --> 01:04:59,795 IT'S NICE AS A BEHAVIORAL 1859 01:04:59,862 --> 01:05:00,730 RESEARCHER HEARING THIS BUT IS 1860 01:05:00,796 --> 01:05:01,797 THERE ANY WAY TO HAVE THIS BUILT 1861 01:05:01,864 --> 01:05:02,498 IN MOVING FORWARD? 1862 01:05:02,565 --> 01:05:04,467 YOU SAID AS WELL THERE'S BEEN AN 1863 01:05:04,533 --> 01:05:04,867 INCREASE. 1864 01:05:04,934 --> 01:05:07,003 AND FUNDING TO SERVICES 1865 01:05:07,069 --> 01:05:08,404 INTERVENTION BASED RESEARCH, SO 1866 01:05:08,471 --> 01:05:09,839 HOW CAN WE ENSURE THIS CONTINUES 1867 01:05:09,905 --> 01:05:11,240 TO BE A FOCUS MOVING FORWARD? 1868 01:05:11,307 --> 01:05:12,842 >> I AM BLESSED WITH THE 1869 01:05:12,908 --> 01:05:14,543 INABILITY TO TELL MY SUCCESSOR 1870 01:05:14,610 --> 01:05:16,312 WHAT TO DO. 1871 01:05:16,379 --> 01:05:19,482 AND IN FACT, I CAN'T EVEN LOBBY 1872 01:05:19,548 --> 01:05:20,916 FOR THAT FOR AT LEAST A YEAR 1873 01:05:20,983 --> 01:05:22,518 AFTER I LEAVE THE GOVERNMENT, 1874 01:05:22,585 --> 01:05:22,718 SO -- 1875 01:05:22,785 --> 01:05:24,153 >> HE OR SHE IS PROBABLY 1876 01:05:24,220 --> 01:05:25,021 LISTENING. 1877 01:05:25,087 --> 01:05:25,288 [LAUGHTER] 1878 01:05:25,354 --> 01:05:28,724 >> SO, YOU KNOW, IT'S BEEN MY 1879 01:05:28,791 --> 01:05:30,793 POLICY AS I STATED VERY EARLY ON 1880 01:05:30,860 --> 01:05:32,128 IN MY TENURE TO HAVE THE 1881 01:05:32,194 --> 01:05:34,730 EXCELLENCE OF THE SCIENCE 1882 01:05:34,797 --> 01:05:36,265 DICTATE THE PORTFOLIO BALANCE 1883 01:05:36,332 --> 01:05:39,635 WITHIN REASON AND TO WORK HARD 1884 01:05:39,702 --> 01:05:42,905 TO INCREASE THE PRESSURE -- THE 1885 01:05:42,972 --> 01:05:44,340 GRANT PRESSURE IN AREAS WHERE WE 1886 01:05:44,407 --> 01:05:46,509 THINK THERE ARE GAPS, AND THAT'S 1887 01:05:46,575 --> 01:05:50,012 BY MY APPROACH IN THIS SERVICES 1888 01:05:50,079 --> 01:05:51,380 AND BEHAVIORAL RESEARCH AREAS 1889 01:05:51,447 --> 01:05:51,781 YOU'RE MENTIONING. 1890 01:05:51,847 --> 01:05:52,848 I WANT TO BE VERY, VERY 1891 01:05:52,915 --> 01:05:53,916 SPECIFIC, I DON'T THINK WE 1892 01:05:53,983 --> 01:05:55,151 ACTUALLY HAVE A PROBLEM IN 1893 01:05:55,217 --> 01:05:56,452 BEHAVIORAL RESEARCH BUT IN THAT 1894 01:05:56,519 --> 01:05:57,553 MORE NEAR TERM RESEARCH. 1895 01:05:57,620 --> 01:05:59,188 YOU AND I MIGHT DIFFER ABOUT 1896 01:05:59,255 --> 01:06:00,156 THAT, THAT'S FINE. 1897 01:06:00,222 --> 01:06:04,093 BUT I WOULD SAY, YOU KNOW, THIS 1898 01:06:04,160 --> 01:06:05,161 IS AN OPPORTUNITY WHEN YOU HIRE 1899 01:06:05,227 --> 01:06:08,130 A NEW DIRECTOR TO HAVE A 1900 01:06:08,197 --> 01:06:09,098 DIRECTOR WHO MIGHT COME IN WITH 1901 01:06:09,165 --> 01:06:09,865 DIFFERENT PRIORITIES. 1902 01:06:09,932 --> 01:06:11,667 AND THAT IS PART OF THE REASON I 1903 01:06:11,734 --> 01:06:13,035 AM LEAVING. 1904 01:06:13,102 --> 01:06:16,839 I'VE HAD MY TURN, BEEN HERE 1905 01:06:16,906 --> 01:06:19,375 EIGHT YEARS, I'VE GOTTEN 1906 01:06:19,442 --> 01:06:20,042 ACCOMPLISHED MOST OF THE THINGS 1907 01:06:20,109 --> 01:06:21,444 I WANT TO ACCOMPLISH AND IT'S 1908 01:06:21,510 --> 01:06:22,712 TIME FOR SOMEONE WITH NEW IDEAS 1909 01:06:22,778 --> 01:06:23,913 AND NEW PRIORITIES TO COME IN. 1910 01:06:23,979 --> 01:06:25,881 SO CERTAINLY THERE'S AN 1911 01:06:25,948 --> 01:06:26,549 OPPORTUNITY NOW. 1912 01:06:26,615 --> 01:06:29,185 HOW CAN YOU INFLUENCE THAT 1913 01:06:29,251 --> 01:06:29,485 OPPORTUNITY? 1914 01:06:29,552 --> 01:06:31,420 FIRST AND FOREMOST, YOU CAN 1915 01:06:31,487 --> 01:06:33,055 ENCOURAGE YOUR COLLEAGUES OR 1916 01:06:33,122 --> 01:06:34,056 CONSIDER YOURSELF APPLYING TO 1917 01:06:34,123 --> 01:06:37,760 TAKE ON THIS POSITION. 1918 01:06:37,827 --> 01:06:39,061 I SEE YOU SHAKING YOUR HEAD. 1919 01:06:39,128 --> 01:06:40,396 I'M HAPPY TO TELL YOU ALL THE 1920 01:06:40,463 --> 01:06:42,198 WONDERFUL REASONS WHY I THINK 1921 01:06:42,264 --> 01:06:43,833 YOU SHOULD, MATT, BUT I RESPECT 1922 01:06:43,899 --> 01:06:44,066 THAT. 1923 01:06:44,133 --> 01:06:46,702 BUT YOU KNOW, THE SEARCH 1924 01:06:46,769 --> 01:06:49,939 COMMITTEE WILL BE ABLE TO PICK 1925 01:06:50,005 --> 01:06:53,109 FROM MANY QUALIFIED CANDIDATE, 1926 01:06:53,175 --> 01:06:55,511 AND IF YOU ARE PEOPLE THAT YOU 1927 01:06:55,578 --> 01:06:56,479 FEEL WOULD LEAD THE INSTITUTE IN 1928 01:06:56,545 --> 01:06:58,013 THE WAY YOU'D LIKE TO SEE IT 1929 01:06:58,080 --> 01:06:59,081 LED, ENCOURAGE THEM TO APPLY. 1930 01:06:59,148 --> 01:06:59,849 LET'S START THERE. 1931 01:06:59,915 --> 01:07:01,450 AND THE SECOND THING I THINK IS 1932 01:07:01,517 --> 01:07:03,986 YOU CAN, YOU KNOW, CERTAINLY 1933 01:07:04,053 --> 01:07:05,755 MAKE YOUR VOICES HEARD TO THE 1934 01:07:05,821 --> 01:07:06,489 NIH DIRECTOR ABOUT WHAT YOU 1935 01:07:06,555 --> 01:07:09,759 THINK THE PRIORITIES ARE. 1936 01:07:09,825 --> 01:07:11,594 I CAN TELL YOU AT THE 1937 01:07:11,660 --> 01:07:12,928 FUNDAMENTAL BASIS THAT NIH STILL 1938 01:07:12,995 --> 01:07:14,897 REMAINS A BIOMEDICAL RESEARCH 1939 01:07:14,964 --> 01:07:15,831 INSTITUTION, AND I THINK WE'RE 1940 01:07:15,898 --> 01:07:17,299 GOING TO SEE THAT THAT'S GOING 1941 01:07:17,366 --> 01:07:19,468 TO BE AN IMPORTANT PART OF THE 1942 01:07:19,535 --> 01:07:20,336 SEARCH. 1943 01:07:20,403 --> 01:07:24,340 , BUT THAT LEAVES TREMENDOUS 1944 01:07:24,407 --> 01:07:26,308 LEEWAY, AND AS I SAID, THE 1945 01:07:26,375 --> 01:07:30,679 HIRING OF A NEW DIRECTOR IS A 1946 01:07:30,746 --> 01:07:33,182 WAY -- IS WHEN BIGGER CHANGES IN 1947 01:07:33,249 --> 01:07:34,049 PRIORITIES HAPPEN. 1948 01:07:34,116 --> 01:07:35,351 I'VE CHANGED MY PRIORITIES ALONG 1949 01:07:35,418 --> 01:07:36,352 THE WAY. 1950 01:07:36,419 --> 01:07:36,952 I'VE LEARNED A LOT FROM ALL OF 1951 01:07:37,019 --> 01:07:38,854 YOU IN THIS ROOM, BOTH NIHERS 1952 01:07:38,921 --> 01:07:39,889 AND COUNCILMEMBERS AS WELL AS 1953 01:07:39,955 --> 01:07:42,525 FROM THE PUBLIC, THE IACC, MANY 1954 01:07:42,591 --> 01:07:43,726 OTHER VENUES. 1955 01:07:43,793 --> 01:07:45,394 SO MY PRIORITIES HAVE CHANGED, 1956 01:07:45,461 --> 01:07:47,797 BUT BIGGER CHANGES HAPPEN WHEN 1957 01:07:47,863 --> 01:07:53,035 NEW PEOPLE TAKE OVER. 1958 01:07:53,102 --> 01:07:53,436 MARGUERITA. 1959 01:07:53,502 --> 01:07:55,638 LET ME JUST SAY TO THOSE -- SO 1960 01:07:55,704 --> 01:07:58,140 NO ONE FEELS LEFT OUT, THERE ARE 1961 01:07:58,207 --> 01:07:59,442 ALSO PEOPLE OUT THERE WHO ARE 1962 01:07:59,508 --> 01:08:01,277 ARGUING THAT WE VEERED AWAY FROM 1963 01:08:01,343 --> 01:08:02,945 THESE AREAS OF BASIC SCIENCE OR 1964 01:08:03,012 --> 01:08:04,680 THESE AREAS OF TRANSLATIONAL 1965 01:08:04,747 --> 01:08:08,717 SCIENCE, SO YOU KNOW, MY IDEAL 1966 01:08:08,784 --> 01:08:09,718 VERSION OF THE PERSON IS SOMEONE 1967 01:08:09,785 --> 01:08:10,820 WHO CAN UNDERSTAND AND 1968 01:08:10,886 --> 01:08:16,158 APPRECIATE ALL TH THE DIFFERENT 1969 01:08:16,225 --> 01:08:17,359 FACETS OF THE PORTFOLIO AND 1970 01:08:17,426 --> 01:08:20,729 THOSE THAT WILL BRING PRIORITIES 1971 01:08:20,796 --> 01:08:22,264 INTO MENTAL HEALTH. 1972 01:08:22,331 --> 01:08:22,565 MARGUERITA. 1973 01:08:22,631 --> 01:08:23,466 >> I SECOND THAT YOU SHOULD 1974 01:08:23,532 --> 01:08:26,569 APPLY FOR THE POSITION. 1975 01:08:26,635 --> 01:08:29,038 >> JOSH, I WANTED TO ALSO ADD, 1976 01:08:29,104 --> 01:08:30,573 WAYS REALLY INTERESTED IN THE 1977 01:08:30,639 --> 01:08:31,774 CLINICAL RESEARCH NETWORK THAT'S 1978 01:08:31,841 --> 01:08:32,341 BEING FORMED. 1979 01:08:32,408 --> 01:08:34,610 I KNOW THAT YOU'VE BEEN VERY 1980 01:08:34,677 --> 01:08:36,812 INVOLVED IN THE NIH COMMON FUND 1981 01:08:36,879 --> 01:08:38,514 AND NIMH HAS BEEN INVOLVED, AND 1982 01:08:38,581 --> 01:08:40,416 I ALSO WAS REALLY APPRECIATING 1983 01:08:40,483 --> 01:08:45,654 THE SENSE OF WANTING TO FOCUS ON 1984 01:08:45,721 --> 01:08:48,057 UNDERSERVED AND UNDERREPRESENTED 1985 01:08:48,123 --> 01:08:49,358 POPULATIONS, AND I'M WONDERING 1986 01:08:49,425 --> 01:08:52,428 HOW -- WHAT ARE THE STRATEGIES 1987 01:08:52,495 --> 01:08:53,729 THAT AS YOU'RE BUILDING THE 1988 01:08:53,796 --> 01:08:56,098 NETWORK, THE STRI STRATEGIES THE 1989 01:08:56,165 --> 01:08:57,333 GOING TO ENSURE THAT THAT IS 1990 01:08:57,399 --> 01:08:59,869 ACTUALLY THE CASE AS OPPOSED TO 1991 01:08:59,935 --> 01:09:01,837 IT BEING LARGE FOLKS WHO ALWAYS 1992 01:09:01,904 --> 01:09:04,340 GET THE MONEY FROM NIMH OR NIH 1993 01:09:04,406 --> 01:09:06,408 IN GENERAL, AND THEY TRY TO 1994 01:09:06,475 --> 01:09:07,843 ENGAGE THE COMMUNITY. 1995 01:09:07,910 --> 01:09:10,913 BUT REALLY AREN'T ACTUALLY 1996 01:09:10,980 --> 01:09:11,680 REACHING THOSE FOLKS THAT WE 1997 01:09:11,747 --> 01:09:12,014 NEED. 1998 01:09:12,081 --> 01:09:14,617 SO I'M WONDERING WHAT KIND OF 1999 01:09:14,683 --> 01:09:16,352 STRATEGIES ARE BEING EMPLOYED TO 2000 01:09:16,418 --> 01:09:18,988 ENSURE THAT WE'RE REACHING THE 2001 01:09:19,054 --> 01:09:20,689 INTENDED AUDIENCE AND JUST ALSO 2002 01:09:20,756 --> 01:09:22,458 ADDING THAT YOU ALSO -- THE 2003 01:09:22,525 --> 01:09:23,659 GROUP MAY WANT TO CONSIDER WHAT 2004 01:09:23,726 --> 01:09:25,094 KIND OF CAPACITY BUILDING 2005 01:09:25,160 --> 01:09:29,865 ACTIVITIES COULD BE DONE SO THAT 2006 01:09:29,932 --> 01:09:30,666 NEW COMMUNITY MENTAL HEALTH 2007 01:09:30,733 --> 01:09:34,069 CENTERS AND ALL THE COMMUNITY 2008 01:09:34,136 --> 01:09:35,938 CLINICS COULD ALSO BE INCLUDED 2009 01:09:36,005 --> 01:09:37,239 SO THAT THE FOLKS WHO AREN'T 2010 01:09:37,306 --> 01:09:39,708 TYPICALLY GETTING FUNDING FROM 2011 01:09:39,775 --> 01:09:40,809 NIMH BUT WHO ARE ACTUALLY, 2012 01:09:40,876 --> 01:09:42,144 WOULDING WITH THE POPULATIONS 2013 01:09:42,211 --> 01:09:48,784 THAT WE'RE SEEKING TO REACH. 2014 01:09:48,851 --> 01:09:50,085 I THOUGHT MAYBE GET BACK TO -- 2015 01:09:50,152 --> 01:09:52,821 CAN'T DO IT THAT QUICKLY, KIND 2016 01:09:52,888 --> 01:09:56,225 OF -- OKAY. 2017 01:09:56,292 --> 01:09:57,459 SO THIS IS THE PROGRAM YOU'RE 2018 01:09:57,526 --> 01:09:57,993 TALKING ABOUT. 2019 01:09:58,060 --> 01:09:59,562 THIS IS DR. BERTAGNOLLI'S SORT 2020 01:09:59,628 --> 01:10:00,596 OF SIGNATURE EFFORT AS NIH 2021 01:10:00,663 --> 01:10:02,765 DIRECTOR AND SHE'S USING A 2022 01:10:02,831 --> 01:10:05,167 COMMON FUND AS A MECHANISM FOR 2023 01:10:05,234 --> 01:10:05,935 THAT. 2024 01:10:06,001 --> 01:10:08,003 I CAN'T SPEAK TO THE STRATEGIES 2025 01:10:08,070 --> 01:10:08,904 THEY'RE GOING TO USE BECAUSE I 2026 01:10:08,971 --> 01:10:10,205 DON'T REALLY KNOW AND THEY JUST 2027 01:10:10,272 --> 01:10:11,840 HIRED A DIRECTOR FOR THIS 2028 01:10:11,907 --> 01:10:12,174 INITIATIVE. 2029 01:10:12,241 --> 01:10:14,343 THE NAME ESCAPES ME AT THIS 2030 01:10:14,410 --> 01:10:16,078 MOMENT BUT IT'S A LONG-TIME 2031 01:10:16,145 --> 01:10:16,312 NIHER. 2032 01:10:16,378 --> 01:10:17,513 I WILL TELL YOU WHAT THEY'RE 2033 01:10:17,580 --> 01:10:17,947 DOING SO FAR. 2034 01:10:18,013 --> 01:10:19,048 SO THE FIRST THING, BECAUSE 2035 01:10:19,114 --> 01:10:20,316 THERE'S NOT NEW MONEY FOR THIS 2036 01:10:20,382 --> 01:10:22,184 JUST YET, RIGHT, THERE'S SOME 2037 01:10:22,251 --> 01:10:24,053 MODEST FUNDS FROM THE COMMON 2038 01:10:24,119 --> 01:10:26,422 FUND TO SUPPLEMENT ESSENTIALLY 2039 01:10:26,488 --> 01:10:27,423 EXISTING CLINICAL NETWORKS, SO 2040 01:10:27,489 --> 01:10:29,525 THEY ASKED ALL THE NIH 2041 01:10:29,592 --> 01:10:33,295 INSTITUTES TO SEND THEM PLACES 2042 01:10:33,362 --> 01:10:34,863 WHERE THEY HAVE INVESTMENTS IN 2043 01:10:34,930 --> 01:10:35,931 RESEARCH BEING DONE AT PRIMARY 2044 01:10:35,998 --> 01:10:36,398 CARE SETTINGS. 2045 01:10:36,465 --> 01:10:41,770 SO WE DID SEND IN OUR EPINET 2046 01:10:41,837 --> 01:10:42,871 NETWORK, WE FELT LIKE IT WAS 2047 01:10:42,938 --> 01:10:44,473 RELEVANT ENOUGH, AND THEY CULLED 2048 01:10:44,540 --> 01:10:46,108 THROUGH THOSE AND ARE LOOKING AT 2049 01:10:46,175 --> 01:10:47,743 THOSE EXISTING NETWORKS AS 2050 01:10:47,810 --> 01:10:50,379 PLACES WHERE THEY CAN SUPPLEMENT 2051 01:10:50,446 --> 01:10:52,281 TO BUILD INFRASTRUCTURE THAT 2052 01:10:52,348 --> 01:10:53,649 COULD FORM THE BASIC BONES OF 2053 01:10:53,716 --> 01:10:54,283 THIS NETWORK. 2054 01:10:54,350 --> 01:10:55,184 THE SECOND PHASE OF THAT IS 2055 01:10:55,250 --> 01:10:56,385 GOING TO BE THE INTERESTING 2056 01:10:56,452 --> 01:10:57,453 PART, WHERE THEY'RE GOING TO 2057 01:10:57,519 --> 01:11:02,725 THEN TRY TO SOLICIT NEW NETWO 2058 01:11:02,791 --> 01:11:03,092 NETWORKS. 2059 01:11:03,158 --> 01:11:06,095 NOW, IN CONTRAST TO THE COMPASS 2060 01:11:06,161 --> 01:11:07,396 INITIATIVE, YOU RECALL FROM ME 2061 01:11:07,463 --> 01:11:08,831 DISCUSSING THAT, THIS IS COMMON 2062 01:11:08,897 --> 01:11:11,600 FUND INITIATIVE AT NIMH THAT I'M 2063 01:11:11,667 --> 01:11:13,302 DEEPLY INVOLVED IN THAT SEEKS TO 2064 01:11:13,369 --> 01:11:14,370 FUND COMMUNITY-BASED 2065 01:11:14,436 --> 01:11:15,904 ORGANIZATIONS AND NOT HEALTHCARE 2066 01:11:15,971 --> 01:11:18,974 ORGANIZATIONS, PER SE, TO 2067 01:11:19,041 --> 01:11:21,477 CONDUCT RESEARCH ON STRUCTURAL 2068 01:11:21,543 --> 01:11:24,013 FACTORS, INTERVENTIONS THAT 2069 01:11:24,079 --> 01:11:25,114 AFFECT STRUCTURAL FACTORS OF 2070 01:11:25,180 --> 01:11:25,981 HEALTH DISPARITIES. 2071 01:11:26,048 --> 01:11:29,051 THIS ONE IS REALLY ABOUT 2072 01:11:29,118 --> 01:11:32,121 BUILDING NETWORKS OF -- CLINICAL 2073 01:11:32,187 --> 01:11:33,155 RESEARCH NETWORKS, SO IT'S GOING 2074 01:11:33,222 --> 01:11:34,523 TO BE HEALTHCARE FACILITIES, 2075 01:11:34,590 --> 01:11:36,125 IT'S GOING TO BE CLINICS, SO 2076 01:11:36,191 --> 01:11:37,226 WHAT THEY'RE GOING TO BE 2077 01:11:37,292 --> 01:11:39,728 FOCUSING IN ON IS WHAT ARE THE 2078 01:11:39,795 --> 01:11:41,230 NETWORKS THAT CAN REACH THE 2079 01:11:41,296 --> 01:11:45,834 COMMUNITIES WE NEED TO REACH? 2080 01:11:45,901 --> 01:11:50,039 SO IT MAY BE A LITTLE LESS ABOUT 2081 01:11:50,105 --> 01:11:51,206 WHO WE'RE FUNDING AND A LITTLE 2082 01:11:51,273 --> 01:11:52,608 MORE ABOUT WHERE THOSE DOLLARS 2083 01:11:52,675 --> 01:11:53,575 ARE GOING AND WHAT ARE THE 2084 01:11:53,642 --> 01:11:54,476 COMMUNITIES THAT ARE BEING 2085 01:11:54,543 --> 01:11:54,910 SERVED. 2086 01:11:54,977 --> 01:11:56,879 I KNOW THERE'S DISCUSSION AS 2087 01:11:56,945 --> 01:11:58,547 INDICATED IN THAT THIRD BULLET 2088 01:11:58,614 --> 01:12:03,552 POINT AROUND ENSURING THAT THESE 2089 01:12:03,619 --> 01:12:04,653 COMMUNITY -- BASED CLINICS ARE 2090 01:12:04,720 --> 01:12:06,221 ENGAGED WITH THE LOCAL COMMUNITY 2091 01:12:06,288 --> 01:12:07,356 AND THAT RESEARCH QUESTIONS THAT 2092 01:12:07,423 --> 01:12:09,425 ARE BEING ADDRESSED ARE RELEVANT 2093 01:12:09,491 --> 01:12:10,959 TO THOSE COMMUNITIES, BUT THEY 2094 01:12:11,026 --> 01:12:12,261 HAVEN'T FIGURED OUT YET HOW 2095 01:12:12,327 --> 01:12:22,805 THEY'RE GOING TO EXSTANTIATE 2096 01:12:25,874 --> 01:12:25,941 THAT. 2097 01:12:26,008 --> 01:12:26,809 >> I'LL KEEP IT BRIEF. 2098 01:12:26,875 --> 01:12:27,776 THANK YOU, JOSH. 2099 01:12:27,843 --> 01:12:29,545 SO FAR THIS MORNING, WE HAVE 2100 01:12:29,611 --> 01:12:32,147 HEARD A LOT ABOUT NIMH 2101 01:12:32,214 --> 01:12:33,482 INVESTMENTS TOWARDS RESEARCH. 2102 01:12:33,549 --> 01:12:36,652 COULD YOU COMMENT A BIT MORE ON 2103 01:12:36,719 --> 01:12:38,754 INVESTMENTS FOR PREDOCK, POSTDOC 2104 01:12:38,821 --> 01:12:40,055 TRAINING OPPORTUNITIES, IN 2105 01:12:40,122 --> 01:12:40,923 PARTICULAR I'M INTERESTED TO SEE 2106 01:12:40,989 --> 01:12:44,860 IF THERE ARE ANY IDEAS FOR THE 2107 01:12:44,927 --> 01:12:46,261 BUDGET INCREASE AND ALLOCATIONS 2108 01:12:46,328 --> 01:12:48,297 TOWARDS TRAINING PROGRAMS. 2109 01:12:48,363 --> 01:12:50,766 >> THAT'S A GOOD QUESTION. 2110 01:12:50,833 --> 01:12:52,401 THE BUDGET INCREASE WAS 2111 01:12:52,468 --> 01:12:55,237 SPECIFICALLY TARGETED AND DID 2112 01:12:55,304 --> 01:13:00,542 NOT INCLUDE LANGUAGE AROUND 2113 01:13:00,609 --> 01:13:00,843 TRAINING. 2114 01:13:00,909 --> 01:13:02,244 AS I MENTIONED THE FACT THAT WE 2115 01:13:02,311 --> 01:13:03,545 RECEIVED AN INCREASE ALLOWED US 2116 01:13:03,612 --> 01:13:05,414 TO BE A LITTLE MORE FLEXIBLE AND 2117 01:13:05,481 --> 01:13:08,283 WE COULD TAKE SOME OF THE 2118 01:13:08,350 --> 01:13:09,718 DOLLARS THAT OTHERWISE WOULD 2119 01:13:09,785 --> 01:13:11,787 HAVE HAD TO HAVE BEEN SPENT TO 2120 01:13:11,854 --> 01:13:14,089 SUPPORT THINGS LIKE IMPACT AND 2121 01:13:14,156 --> 01:13:15,624 PUT A MODEST INCREASE IN OUR 2122 01:13:15,691 --> 01:13:15,991 TRAINING BUDGET. 2123 01:13:16,058 --> 01:13:18,227 SO I WOULD SAY WE'RE BETTER 2124 01:13:18,293 --> 01:13:19,762 OFFER IN TERMS OF OUR TRAINING 2125 01:13:19,828 --> 01:13:21,029 GRANTS THAN OTHER INSTITUTES 2126 01:13:21,096 --> 01:13:22,498 WHICH RECEIVED A FLAT BUDGET, 2127 01:13:22,564 --> 01:13:24,800 BUT THE BUDGET WAS NOT -- DID 2128 01:13:24,867 --> 01:13:30,272 NOT SPECIFY CHANGES IN TRAINING 2129 01:13:30,339 --> 01:13:30,706 APPROACHES. 2130 01:13:30,773 --> 01:13:32,641 WHAT I WOULD SAY IS WE'VE BEEN 2131 01:13:32,708 --> 01:13:34,376 NOW INVOLVED FOR ABOUT A YEAR IN 2132 01:13:34,443 --> 01:13:36,478 REALLY LOOKING AT OUR TRAINING 2133 01:13:36,545 --> 01:13:38,013 PORTFOLIO, AND I JUST RECEIVED A 2134 01:13:38,080 --> 01:13:39,448 COUPLE WEEKS AGO THE REPORT OF 2135 01:13:39,515 --> 01:13:41,183 THAT WORK OF OUR TRAINING TEAM 2136 01:13:41,250 --> 01:13:45,420 REALLY DETAILING THE INVESTMENTS 2137 01:13:45,487 --> 01:13:46,188 AND WHERE THEY ARE. 2138 01:13:46,255 --> 01:13:47,289 THAT REPORT IS GOING TO BE 2139 01:13:47,356 --> 01:13:49,224 HANDED RIGHT OVER TO SHELLI AND 2140 01:13:49,291 --> 01:13:51,226 HANDED RIGHT OVER TO OUR NEW 2141 01:13:51,293 --> 01:13:54,496 DIRECTOR, AND I'M CERTAINLY 2142 01:13:54,563 --> 01:13:55,597 HOPEFUL THAT WE CAN LOOK AT 2143 01:13:55,664 --> 01:13:56,899 WHERE OUR INVESTMENTS ARE, AND 2144 01:13:56,965 --> 01:13:59,101 HOW THEY ARE ACHIEVING OUR 2145 01:13:59,168 --> 01:14:00,402 STATED GOALS IN TRAINING. 2146 01:14:00,469 --> 01:14:03,138 SO WE'VE STATED THAT WE WANT TO 2147 01:14:03,205 --> 01:14:04,673 IMPROVE -- INCREASE THE NUMBER 2148 01:14:04,740 --> 01:14:09,912 OF CLINICIAN-SCIENTISTS THAT WE 2149 01:14:09,978 --> 01:14:12,014 WE -- WE WANT TO BE ABLE TO 2150 01:14:12,080 --> 01:14:14,283 ENSURE THAT THE HAVE-NOTS IN THE 2151 01:14:14,349 --> 01:14:16,819 RESEARCH ECOSYSTEM ARE 2152 01:14:16,885 --> 01:14:19,988 EQUITABLY, YOU KNOW, EQUITABLY 2153 01:14:20,055 --> 01:14:21,190 TREATED ESPECIALLY IN THIS 2154 01:14:21,256 --> 01:14:23,592 TRAINING DOMAIN, ARE THESE 2155 01:14:23,659 --> 01:14:24,893 MECHANISMS ACHIEVING THAT GOAL. 2156 01:14:24,960 --> 01:14:26,528 AND SO WE'RE AT THE STAGE NOW 2157 01:14:26,595 --> 01:14:28,831 WHERE WE HAVE THE INVENTORY AND 2158 01:14:28,897 --> 01:14:30,399 THE DETAILS AND NOW WE NEED TO 2159 01:14:30,465 --> 01:14:31,967 DO SOME ANALYSES TO FIGURE OUT 2160 01:14:32,034 --> 01:14:33,836 WHERE ARE WE ACHIEVING OUR 2161 01:14:33,902 --> 01:14:35,470 GOALS, SO I EXPECT THAT TO COME 2162 01:14:35,537 --> 01:14:36,772 BEFORE THIS BODY IN THE COMING 2163 01:14:36,839 --> 01:14:42,411 YEARS. 2164 01:14:42,477 --> 01:14:44,046 >> I REALLY JUST WANT TO ECHO 2165 01:14:44,112 --> 01:14:46,014 YOUR QUESTION AND ALSO HOW CAN 2166 01:14:46,081 --> 01:14:47,649 WE CONTINUE TO ADVOCATE FOR THAT 2167 01:14:47,716 --> 01:14:52,788 BECAUSE I WORRY THAT JUST AS 2168 01:14:52,855 --> 01:14:56,725 POSTDOCS ARE AT RISK OF 2169 01:14:56,792 --> 01:14:57,726 DIMINISHING, THE SAME WILL BE 2170 01:14:57,793 --> 01:15:00,329 TRUE FOR GRADUATE STUDENTS, 2171 01:15:00,395 --> 01:15:01,296 T32s ARE NOT KEEPING UP WITH 2172 01:15:01,363 --> 01:15:02,297 THE COST OF TRAINING. 2173 01:15:02,364 --> 01:15:03,966 SO IT'S A REAL CONCERN. 2174 01:15:04,032 --> 01:15:06,001 >> WELL, YOU KNOW, I WOULD SAY 2175 01:15:06,068 --> 01:15:08,837 THAT YOUR AID IN FIGURING OUT 2176 01:15:08,904 --> 01:15:11,240 THE BEST WAYS TO SPEND DOLLARS 2177 01:15:11,306 --> 01:15:16,511 THAT WILL BE LIMITED WILL BE -- 2178 01:15:16,578 --> 01:15:18,914 I SAID I'D ACHIEVE MOST OF WHAT 2179 01:15:18,981 --> 01:15:20,148 I SET OUT TO DO. 2180 01:15:20,215 --> 01:15:21,550 ONE OF THE THINGS I REALLY 2181 01:15:21,617 --> 01:15:22,818 DIDN'T ACHIEVE IS THE ABILITY TO 2182 01:15:22,885 --> 01:15:25,287 FIGURE OUT THIS ISSUE OF -- 2183 01:15:25,354 --> 01:15:26,622 PARTICULARLY AROUND HAVEs AND 2184 01:15:26,688 --> 01:15:27,789 HAVE NOTs IN THE MECHANISMS 2185 01:15:27,856 --> 01:15:28,423 THAT WE HAVE. 2186 01:15:28,490 --> 01:15:30,392 WE HAVE WONDERFUL INDIVIDUAL 2187 01:15:30,459 --> 01:15:31,827 FELLOWSHIPS, AND THOSE 2188 01:15:31,894 --> 01:15:33,028 INDIVIDUAL FELLOWSHIPS ARE VERY, 2189 01:15:33,095 --> 01:15:34,463 VERY COMPETITIVE AND THEY'RE 2190 01:15:34,529 --> 01:15:36,098 FUNDED AT VERY, VERY LOW RATES, 2191 01:15:36,164 --> 01:15:37,299 WHICH MEANS ONLY OUTSTANDING 2192 01:15:37,366 --> 01:15:37,933 PEOPLE GET THEM. 2193 01:15:38,000 --> 01:15:41,103 BUT DOES THAT MEAN THAT 2194 01:15:41,169 --> 01:15:43,071 OUTSTANDING PEOPLE WHO WOULDN'T 2195 01:15:43,138 --> 01:15:44,806 BE OUTSTANDING OR WOULDN'T 2196 01:15:44,873 --> 01:15:46,808 DEVELOP IN AN OUTSTANDING WAY IF 2197 01:15:46,875 --> 01:15:48,243 THEY DIDN'T GET IT, MIGHT THOSE 2198 01:15:48,310 --> 01:15:49,912 DOLLARS BE BETTER SPENT WHERE 2199 01:15:49,978 --> 01:15:51,179 PEOPLE -- AT INSTITUTIONS OR IN 2200 01:15:51,246 --> 01:15:52,714 LABS THAT AREN'T WELL-FUNDED, 2201 01:15:52,781 --> 01:15:54,249 AND DO WE HAVE A MENG NISM FOR 2202 01:15:54,316 --> 01:15:58,287 THAT, CAN WE DO THAT? 2203 01:15:58,353 --> 01:15:59,721 THAT'S AN AREA I'VE BEEN REALLY 2204 01:15:59,788 --> 01:16:01,023 INTERESTED IN AND I'VE NOT BEEN 2205 01:16:01,089 --> 01:16:01,690 ABLE TO CRACK. 2206 01:16:01,757 --> 01:16:03,125 SO THERE ARE OTHER THINGS LIKE 2207 01:16:03,191 --> 01:16:04,326 THAT. 2208 01:16:04,393 --> 01:16:05,761 YOU MAY HAVE DIFFERENT 2209 01:16:05,827 --> 01:16:07,062 PRIORITIES WHEN YOU LOOK AT OUR 2210 01:16:07,129 --> 01:16:08,163 TRAINING PORTFOLIO. 2211 01:16:08,230 --> 01:16:13,535 AS MEMBERS OF COUNCIL, YOU CAN 2212 01:16:13,602 --> 01:16:15,270 ASK TO CONTINUE DOWN THIS PATH 2213 01:16:15,337 --> 01:16:17,572 AND EVALUATING THE TRAINING 2214 01:16:17,639 --> 01:16:20,208 PORTFOLIO AND IS IT GOING TO 2215 01:16:20,275 --> 01:16:21,510 ACHIEVE WHAT WE WANT TO ACHIEVE, 2216 01:16:21,576 --> 01:16:22,811 WHAT OUR GOALS ARE AS AN 2217 01:16:22,878 --> 01:16:24,112 INSTITUTE, SO I ENCOURAGE YOU TO 2218 01:16:24,179 --> 01:16:24,479 DO THAT. 2219 01:16:24,546 --> 01:16:26,214 OF COURSE AS A MEMBER OF THE 2220 01:16:26,281 --> 01:16:27,015 SCIENTIFIC COMMUNITY AND MEMBER 2221 01:16:27,082 --> 01:16:28,817 OF THE PUBLIC, I JUST TOLD YOU 2222 01:16:28,884 --> 01:16:30,919 THE LIMITING FACTOR, THE BIGGEST 2223 01:16:30,986 --> 01:16:32,521 LIMITING FACTOR IN EX-PENDING 2224 01:16:32,587 --> 01:16:34,089 OUR TRAINING PORTFOLIO IS OUR 2225 01:16:34,156 --> 01:16:34,756 OVERALL BUDGET. 2226 01:16:34,823 --> 01:16:37,059 IF SALARIES AND STIPENDS GO UP 2227 01:16:37,125 --> 01:16:38,360 AND OUR OVERALL BUDGET DOES NOT 2228 01:16:38,427 --> 01:16:40,195 GO UP, THAT MEANS THE NUMBER OF 2229 01:16:40,262 --> 01:16:41,430 SLOTS WILL GO DOWN. 2230 01:16:41,496 --> 01:16:43,732 AND SO THAT'S -- WHATEVER YOU 2231 01:16:43,799 --> 01:16:49,938 CAN DO AS A MEMBER OF THE PUBLIC 2232 01:16:50,005 --> 01:16:51,373 TO SUPPORT THE BUDGET, THAT'S 2233 01:16:51,440 --> 01:16:55,510 ANOTHER WAY YOU COULD DO IT. 2234 01:16:55,577 --> 01:17:00,182 HOPE I DIDN'T CROSS ANY -- 2235 01:17:00,248 --> 01:17:01,984 >> THANK YOU, JOSH, FOR BEING A 2236 01:17:02,050 --> 01:17:03,552 CHAMPION FOR IMPLEMENTATION 2237 01:17:03,618 --> 01:17:07,556 SCIENCE AND IMPACT. 2238 01:17:07,622 --> 01:17:10,158 I JUST WANT TO PIGGY BACK OFF 2239 01:17:10,225 --> 01:17:12,160 WHAT DR. LIGHTFOOT SAID ABOUT 2240 01:17:12,227 --> 01:17:14,129 THIS PROGRAM AND I UNDERSTAND 2241 01:17:14,196 --> 01:17:17,065 IT'S NIH WIDE BUT ON MY WISH 2242 01:17:17,132 --> 01:17:19,534 LIST, I'D LIKE TO SEE A SCALE UP 2243 01:17:19,601 --> 01:17:21,136 ON IMPLEMENTATION SCIENCE AND 2244 01:17:21,203 --> 01:17:26,975 ALSO THINK NING TO REALLY MAXIME 2245 01:17:27,042 --> 01:17:29,111 THE POTENTIAL IMPACT WE CAN HAVE 2246 01:17:29,177 --> 01:17:29,878 FOR OUR COMMUNITIES. 2247 01:17:29,945 --> 01:17:31,213 >> THANK YOU FOR THAT COMMENT. 2248 01:17:31,279 --> 01:17:33,749 I'M NOT 100% SURE THAT THAT'S 2249 01:17:33,815 --> 01:17:35,784 THE GOAL OF THIS NETWORK. 2250 01:17:35,851 --> 01:17:37,552 SO IF YOU'RE INTERESTED IN THAT, 2251 01:17:37,619 --> 01:17:40,489 THAT MIGHT REQUIRE SOME ACTIVE 2252 01:17:40,555 --> 01:17:42,357 ENGAGEMENT ON YOUR PART. 2253 01:17:42,424 --> 01:17:43,759 BECAUSE I'LL BE HONEST, THAT'S 2254 01:17:43,825 --> 01:17:45,727 NOT THE WAY IT BEEN 2255 01:17:45,794 --> 01:17:46,194 CONCEPTUALIZED. 2256 01:17:46,261 --> 01:17:49,131 IT'S A WAY TO CONCEPTUALIZE 2257 01:17:49,197 --> 01:17:50,565 DOING CLINICAL TRIALS, LIKE 2258 01:17:50,632 --> 01:17:52,534 GENUINE CLINICAL TRIALS, NOT 2259 01:17:52,601 --> 01:17:53,435 IMPLEMENTATION SCIENCE, BUT 2260 01:17:53,502 --> 01:17:56,705 TRIALS OF NOVEL THERAPIES OR 2261 01:17:56,772 --> 01:17:58,673 EFFECTIVENESS TRIALS, ET CETERA. 2262 01:17:58,740 --> 01:18:00,976 IN REAL WORLD SETTINGS WITH THE 2263 01:18:01,043 --> 01:18:02,411 POPULATIONS THAT WE FIND VERY, 2264 01:18:02,477 --> 01:18:06,882 VERY DIFFICULT TO REACH. 2265 01:18:06,948 --> 01:18:09,951 SO IT DOES HAVE THE GOAL OF 2266 01:18:10,018 --> 01:18:11,586 MAKING TREATMENTS MORE 2267 01:18:11,653 --> 01:18:13,221 ACCESSIBLE BUT IN AN EARLIER 2268 01:18:13,288 --> 01:18:15,457 TRANSLATIONAL PATHWAY THAN 2269 01:18:15,524 --> 01:18:16,391 IMPLEMENTATION -- THAT'S JUST TO 2270 01:18:16,458 --> 01:18:17,926 ME, FROM WHAT I'VE HEARD ABOUT 2271 01:18:17,993 --> 01:18:20,896 THIS PROGRAM, THAT'S THE GOAL. 2272 01:18:20,962 --> 01:18:22,197 SO IF YOU THINK THAT THIS 2273 01:18:22,264 --> 01:18:25,367 PROGRAM COULD BE USED IN OTHER 2274 01:18:25,434 --> 01:18:27,002 WAYS, THAT MAY REQUIRE SOME 2275 01:18:27,069 --> 01:18:27,702 ACTIVE ADVOCACY. 2276 01:18:27,769 --> 01:18:33,041 >> THAT'S THE PERFECT PLACE FOR 2277 01:18:33,108 --> 01:18:33,575 IMPLEMENTATION SCIENCE. 2278 01:18:33,642 --> 01:18:33,975 SO THANK YOU. 2279 01:18:34,042 --> 01:18:35,444 >> ALL RIGHT. 2280 01:18:35,510 --> 01:18:36,211 WELL, THANK YOU VERY MUCH FOR 2281 01:18:36,278 --> 01:18:37,679 ALL YOUR QUESTIONS AND COMMENTS 2282 01:18:37,746 --> 01:18:39,081 AND ALSO FOR YOUR HEARTFELT 2283 01:18:39,147 --> 01:18:39,414 WORDS. 2284 01:18:39,481 --> 01:18:41,917 AND I'M GRATEFUL THAT NONE OF 2285 01:18:41,983 --> 01:18:45,253 YOU WENT ON TOO LONG IN THAT W 2286 01:18:45,320 --> 01:18:47,889 WAY. 2287 01:18:47,956 --> 01:18:48,890 AGAIN, THIS HAS BEEN THE BEST 2288 01:18:48,957 --> 01:18:49,057 JOB. 2289 01:18:49,124 --> 01:18:51,893 I CAN'T IMAGINE A BETTER ONE, 2290 01:18:51,960 --> 01:18:53,762 AND I'M MOVING ON FOR MANY OTHER 2291 01:18:53,829 --> 01:18:55,063 REASONS AND REALLY EXCITED ABOUT 2292 01:18:55,130 --> 01:19:01,002 THAT, BUT ALSO SAD, AND LOOK 2293 01:19:01,069 --> 01:19:01,736 FORWARD TO THE REST OF THE 2294 01:19:01,803 --> 01:19:02,404 PROGRAM. 2295 01:19:02,471 --> 01:19:07,642 I THINK NEXT WE HAVE A VIDEO 2296 01:19:07,709 --> 01:19:18,253 STATEMENT FROM DR. BERTAGNOLLI. 2297 01:19:20,455 --> 01:19:22,023 SO WE DID INVITE DR. BERTAGNOLLI 2298 01:19:22,090 --> 01:19:23,425 TO OUR COUNCIL MEETING AND SHE 2299 01:19:23,492 --> 01:19:25,060 ACCEPT AND WE WERE VERY EXCITED 2300 01:19:25,127 --> 01:19:26,495 AND UNFORTUNATELY, SHE HAD 2301 01:19:26,561 --> 01:19:28,230 OFFICIAL TRAVEL THAT HAD TO TAKE 2302 01:19:28,296 --> 01:19:29,998 PRECEDENCE AND IS UNABLE TO JOIN 2303 01:19:30,065 --> 01:19:31,533 US IN PERSON. 2304 01:19:31,600 --> 01:19:34,136 SO SHE HAS PREPARED SOME VIDEO 2305 01:19:34,202 --> 01:19:35,170 REMARKS, WHICH WE WILL NOW PLAY 2306 01:19:35,237 --> 01:19:37,672 FOR YOU. 2307 01:19:37,739 --> 01:19:39,074 >> HELLO, EVERYONE. 2308 01:19:39,141 --> 01:19:40,742 I'M HONORED TO BE SPEAKING TO 2309 01:19:40,809 --> 01:19:42,878 YOU TODAY AS THE 17TH DIRECTOR 2310 01:19:42,944 --> 01:19:44,146 OF THE NATIONAL INSTITUTES OF 2311 01:19:44,212 --> 01:19:45,447 HEALTH. 2312 01:19:45,514 --> 01:19:47,883 WHEN I GOT THE CALL ASKING ME TO 2313 01:19:47,949 --> 01:19:49,651 COME WORK AT NIH, I DID NOT 2314 01:19:49,718 --> 01:19:51,486 HESITATE TO SAY YES. 2315 01:19:51,553 --> 01:19:54,723 I'VE ALWAYS ADMIRED NIH AND I AM 2316 01:19:54,789 --> 01:19:56,725 THRILLED TO BE IN A PLACE WHERE 2317 01:19:56,791 --> 01:19:58,593 EVERYTHING WE DO REVOLVES AROUND 2318 01:19:58,660 --> 01:20:00,695 A SINGLE GOAL, IMPROVING THE 2319 01:20:00,762 --> 01:20:03,665 HEALTH OF THE AMERICAN PEOPLE. 2320 01:20:03,732 --> 01:20:06,601 OUR JOB AT NIH IS CLEAR, IF NOT 2321 01:20:06,668 --> 01:20:07,369 STRAIGHTFORWARD. 2322 01:20:07,435 --> 01:20:09,905 WE ARE HERE TO SEEK FUNDAMENTAL 2323 01:20:09,971 --> 01:20:11,473 KNOWLEDGE ABOUT LIVING SYSTEMS 2324 01:20:11,540 --> 01:20:13,742 AND TO APPLY THAT KNOWLEDGE TO 2325 01:20:13,808 --> 01:20:16,244 ENHANCE HEALTH FOR ALL. 2326 01:20:16,311 --> 01:20:18,547 AS NIH DIRECTOR, I'M CONCERNED 2327 01:20:18,613 --> 01:20:20,115 ABOUT SOME DISTURBING TRENDS IN 2328 01:20:20,182 --> 01:20:21,316 THE OVERALL HEALTH OF THE 2329 01:20:21,383 --> 01:20:23,385 AMERICAN PEOPLE. 2330 01:20:23,451 --> 01:20:25,453 LIFE EXPECTANCY IN THE U.S. IS 2331 01:20:25,520 --> 01:20:27,656 LOW COMPARED WITH PEER NATIONS, 2332 01:20:27,722 --> 01:20:29,824 EVEN THOUGH WE SPEND MUCH MORE 2333 01:20:29,891 --> 01:20:32,561 THAN OTHER COUNTRIES ON OUR 2334 01:20:32,627 --> 01:20:33,662 HEALTH SYSTEM. 2335 01:20:33,728 --> 01:20:35,864 U.S. LIFE INSPECT SEAL ACTUALLY 2336 01:20:35,931 --> 01:20:37,632 DECLINED OVER THE LAST DECADE, 2337 01:20:37,699 --> 01:20:39,701 AND THIS DECLINE APPEARS LARGELY 2338 01:20:39,768 --> 01:20:41,603 TO BE DUE TO AN INCREASE IN 2339 01:20:41,670 --> 01:20:45,106 DEATHS OF DESPAIR, CAUSED BY 2340 01:20:45,173 --> 01:20:50,111 DRUG POISONING, SUBSTANCE USE, 2341 01:20:50,178 --> 01:20:52,214 SUICIDES, AND CARDIOMETABOLIC 2342 01:20:52,280 --> 01:20:55,784 DISEASES IN WORKING-AGE ADULTS. 2343 01:20:55,850 --> 01:20:57,519 WE NEED BEHAVIORAL AS WELL AS 2344 01:20:57,586 --> 01:20:58,954 BIOMEDICAL RESEARCH TO ADDRESS 2345 01:20:59,020 --> 01:21:00,755 THE CHALLENGES TROUBLING 2346 01:21:00,822 --> 01:21:02,557 AMERICAN HEALTH. 2347 01:21:02,624 --> 01:21:04,759 MENTAL HEALTH RESEARCH IS 2348 01:21:04,826 --> 01:21:06,728 PARTICULARLY DEMANDING, BECAUSE 2349 01:21:06,795 --> 01:21:10,899 OF CHALLENGES SUCH AS ACCURATE 2350 01:21:10,966 --> 01:21:12,534 DIAGNOSIS AND THE LONG DURATION 2351 01:21:12,601 --> 01:21:13,301 OF MENTAL ILLNESS. 2352 01:21:13,368 --> 01:21:14,936 BUT IT'S SO IMPORTANT THAT WE 2353 01:21:15,003 --> 01:21:19,441 MAKE PROGRESS IN UNDERSTANDING 2354 01:21:19,507 --> 01:21:21,576 IN COMBATING MENTAL ILLNESSES 2355 01:21:21,643 --> 01:21:23,044 WHICH CAUSE SO MUCH DISABILITY 2356 01:21:23,111 --> 01:21:24,479 AND, TOO OFTEN, DEATH. 2357 01:21:24,546 --> 01:21:25,814 TO IMPROVE THE HEALTH OF THE 2358 01:21:25,880 --> 01:21:28,650 AMERICAN PEOPLE, I SEE TWO MAJOR 2359 01:21:28,717 --> 01:21:30,151 CHALLENGES THAT NIH NEEDS TO 2360 01:21:30,218 --> 01:21:33,288 RESPOND TO. 2361 01:21:33,355 --> 01:21:34,689 FIRST, MANY COMMUNITIES ARE 2362 01:21:34,756 --> 01:21:36,858 UNDERREPRESENTED IN RESEARCH. 2363 01:21:36,925 --> 01:21:39,060 DATA IS ESPECIALLY LACKING FOR 2364 01:21:39,127 --> 01:21:41,930 POPULATIONS THAT ARE OLDER, 2365 01:21:41,997 --> 01:21:43,465 UNINSURED, BELONG TO MINORITY 2366 01:21:43,531 --> 01:21:44,766 GROUPS OR LIVE IN RURAL 2367 01:21:44,833 --> 01:21:47,002 LOCATIONS. 2368 01:21:47,068 --> 01:21:48,703 SECOND, RESEARCH KNOWLEDGE IS 2369 01:21:48,770 --> 01:21:51,573 NOT BEING EFFECTIVELY HARNESSED. 2370 01:21:51,640 --> 01:21:52,807 FUNDAMENTALLY FOR ALL THE WEALTH 2371 01:21:52,874 --> 01:21:54,776 OF DATA WE ARE ABLE TO COLLECT, 2372 01:21:54,843 --> 01:21:56,745 WE LACK SUFFICIENT INFORMATION 2373 01:21:56,811 --> 01:22:00,882 TO GUIDE CLINICAL CARE. 2374 01:22:00,949 --> 01:22:03,918 AMONG MY GUIDING PRINCIPLES AS 2375 01:22:03,985 --> 01:22:06,054 DIRECTOR OF NIH, ONE OF MY VERY 2376 01:22:06,121 --> 01:22:07,589 FIRST ONE IS OUR WORK IS NOT 2377 01:22:07,656 --> 01:22:12,294 FINISHED WHEN WE MAKE SCIENTIFIC 2378 01:22:12,360 --> 01:22:13,061 DISCOVERIES, IT'S WHEN ALL 2379 01:22:13,128 --> 01:22:14,929 PEOPLE ARE LIVING HEALTHY LIVES. 2380 01:22:14,996 --> 01:22:15,697 FUNDAMENTAL SCIENCE IS THE 2381 01:22:15,764 --> 01:22:17,432 FOUNDATION OF ALL THAT NIH DOES. 2382 01:22:17,499 --> 01:22:19,434 WE'RE LEARNING SO MUCH ABOUT 2383 01:22:19,501 --> 01:22:21,202 HUMAN BIOLOGY IN OUR BASIC 2384 01:22:21,269 --> 01:22:23,405 RESEARCH LABORATORIES. 2385 01:22:23,471 --> 01:22:25,473 BUT AS THE RUSH OF INFORMATION 2386 01:22:25,540 --> 01:22:28,643 COMES IN, WE MUST BECOME MORE 2387 01:22:28,710 --> 01:22:31,513 EFFECTIVE IN CONNECTING WHAT WE 2388 01:22:31,579 --> 01:22:32,947 LEARN, UNDERSTANDING THE 2389 01:22:33,014 --> 01:22:34,783 INTERPLAY BETWEEN THE GENES WE 2390 01:22:34,849 --> 01:22:36,651 INHERIT AND THE ENVIRONMENTAL 2391 01:22:36,718 --> 01:22:38,453 AND SOCIETAL FACTORS THAT 2392 01:22:38,520 --> 01:22:40,955 SURROUND US, BEGINNING EVEN 2393 01:22:41,022 --> 01:22:43,124 BEFORE BIRTH, AND CONNECTING 2394 01:22:43,191 --> 01:22:44,492 THAT KNOWLEDGE TO EVERYDAY LIFE 2395 01:22:44,559 --> 01:22:46,227 AND CLINICAL PRACTICE. 2396 01:22:46,294 --> 01:22:48,730 WE NEED TO MAKE SURE THAT THE 2397 01:22:48,797 --> 01:22:50,031 BIOLOGICAL INSIGHTS IDENTIFIED 2398 01:22:50,098 --> 01:22:52,033 IN LABORATORIES ARE RAPIDLY 2399 01:22:52,100 --> 01:22:54,102 PURSUED IN WAYS THAT SPEED THEIR 2400 01:22:54,169 --> 01:22:55,970 INNOVATION TO IMPROVE THE 2401 01:22:56,037 --> 01:22:59,274 CIRCUMSTANCES OF REAL PEOPLE. 2402 01:22:59,341 --> 01:23:03,945 NIH RESEARCH ENCOMPASSES THE 2403 01:23:04,012 --> 01:23:06,481 LABORATORY, THE CLINIC AND ALL 2404 01:23:06,548 --> 01:23:07,148 COMMUNITIES, AND PATIENTS ARE 2405 01:23:07,215 --> 01:23:08,917 OUR PARTNERS IN DISCOVERY. 2406 01:23:08,983 --> 01:23:10,785 MY HOPE FOR NIH IS THAT IN THE 2407 01:23:10,852 --> 01:23:11,986 COMING YEARS, WE WILL BETTER 2408 01:23:12,053 --> 01:23:13,722 CONNECT RESEARCH WITH EVERYDAY 2409 01:23:13,788 --> 01:23:15,290 PATIENT CARE. 2410 01:23:15,357 --> 01:23:17,959 TO TRULY DELIVER EVIDENCE-BASED 2411 01:23:18,026 --> 01:23:19,661 HEALTHCARE BY INTEGRATING ALL 2412 01:23:19,728 --> 01:23:21,429 FORMS OF RELEVANT DATA. 2413 01:23:21,496 --> 01:23:23,198 AND BY GIVING PATIENTS ACROSS 2414 01:23:23,264 --> 01:23:25,367 THE COUNTRY THE OPTION TO 2415 01:23:25,433 --> 01:23:26,134 PARTICIPATE IN CLINICAL 2416 01:23:26,201 --> 01:23:30,638 RESEARCH. 2417 01:23:30,705 --> 01:23:32,607 NIH CAN ALSO HELP MAKE ADVANCED 2418 01:23:32,674 --> 01:23:33,908 SCIENTIFIC METHODS SUCH AS NEW 2419 01:23:33,975 --> 01:23:35,443 TECHNOLOGIES AND NEW DATA 2420 01:23:35,510 --> 01:23:37,212 ANALYTICS MORE WIDELY AVAILABLE 2421 01:23:37,278 --> 01:23:40,949 TO HELP DELIVER DATA-DRIVEN 2422 01:23:41,015 --> 01:23:42,150 HEALTHCARE. 2423 01:23:42,217 --> 01:23:44,219 ARTIFICIAL INTELLIGENCE IS 2424 01:23:44,285 --> 01:23:46,321 ALREADY REVOLUTIONIZING WHAT IS 2425 01:23:46,388 --> 01:23:47,722 POSSIBLE FOR BIOMEDICAL RESEARCH 2426 01:23:47,789 --> 01:23:48,590 AND CLINICAL CARE. 2427 01:23:48,656 --> 01:23:51,159 BUT TO REALIZE ITS POTENTIAL FOR 2428 01:23:51,226 --> 01:23:52,460 IMPROVING HEALTH, WE NEED TO 2429 01:23:52,527 --> 01:23:54,529 INVEST IN A SECURE AND 2430 01:23:54,596 --> 01:23:56,931 SUSTAINABLE DATA SHARING 2431 01:23:56,998 --> 01:23:57,832 INFRASTRUCTURE. 2432 01:23:57,899 --> 01:23:59,501 IN SHORT, MY GOAL AS NIH 2433 01:23:59,567 --> 01:24:01,002 DIRECTOR IS TO WORK TOWARD 2434 01:24:01,069 --> 01:24:02,871 MAKING SURE THAT EVERYONE HAS 2435 01:24:02,937 --> 01:24:04,439 ACCESS TO EVIDENCE-BASED 2436 01:24:04,506 --> 01:24:06,408 TREATMENTS AND THE OPPORTUNITY 2437 01:24:06,474 --> 01:24:09,477 TO PARTICIPATE IN AND BENEFIT 2438 01:24:09,544 --> 01:24:11,379 FROM BIOMEDICAL AND BEHAVIORAL 2439 01:24:11,446 --> 01:24:13,348 RESEARCH. 2440 01:24:13,415 --> 01:24:15,216 BEFORE CLOSING, I HAVE TO 2441 01:24:15,283 --> 01:24:16,284 ACKNOWLEDGE THAT THIS IS THE 2442 01:24:16,351 --> 01:24:19,387 LAST MEETING OF THIS GROUP WITH 2443 01:24:19,454 --> 01:24:20,588 DR. JOSHUA GORDON SERVING AS 2444 01:24:20,655 --> 01:24:22,490 DIRECTOR OF THE NATIONAL 2445 01:24:22,557 --> 01:24:23,858 INSTITUTE OF MENTAL HEALTH. 2446 01:24:23,925 --> 01:24:26,327 WE HAVE BEEN SO FORTUNATE TO 2447 01:24:26,394 --> 01:24:28,029 HAVE HAD HIS LEADERSHIP FOR THE 2448 01:24:28,096 --> 01:24:29,564 PAST EIGHT YEARS. 2449 01:24:29,631 --> 01:24:32,400 A VISIONARY PSYCHIATRIST AND 2450 01:24:32,467 --> 01:24:34,068 NEUROSCIENTIST, DR. GORDON HAS 2451 01:24:34,135 --> 01:24:36,604 OVERSEEN AN EXTENSIVE PORTFOLIO 2452 01:24:36,671 --> 01:24:38,773 OF BASIC, TRANSLATIONAL, AND 2453 01:24:38,840 --> 01:24:40,341 CLINICAL RESEARCH. 2454 01:24:40,408 --> 01:24:41,743 HE FOCUSED ON RESEARCH 2455 01:24:41,810 --> 01:24:44,179 PRIORITIES LIKE SUICIDE 2456 01:24:44,245 --> 01:24:45,246 PREVENTION, EXPANDING NEURAL 2457 01:24:45,313 --> 01:24:47,348 CIRCUIT RESEARCH TO INCLUDE 2458 01:24:47,415 --> 01:24:49,517 TRANSLATION EFFORTS, AND 2459 01:24:49,584 --> 01:24:51,386 INCREASING OUR INVESTMENTS IN 2460 01:24:51,453 --> 01:24:53,154 COMPUTATIONAL PSYCHIATRY TO 2461 01:24:53,221 --> 01:24:55,290 EXPAND THE MATHEMATICAL AND 2462 01:24:55,356 --> 01:24:57,125 THEORETICAL APPROACHES TO MENTAL 2463 01:24:57,192 --> 01:24:58,960 HEALTH RESEARCH. 2464 01:24:59,027 --> 01:25:01,162 UNDER HIS LEADERSHIP, NIMH HAS 2465 01:25:01,229 --> 01:25:03,398 BEEN INVOLVED IN DEVELOPING NEW 2466 01:25:03,465 --> 01:25:05,567 MEDICATIONS AND OTHER 2467 01:25:05,633 --> 01:25:06,568 INTERVENTIONS, NEW APPROACHES TO 2468 01:25:06,634 --> 01:25:08,403 SCREENING AND RISK REDUCTION, 2469 01:25:08,470 --> 01:25:11,072 AND THE RAPID EVOLUTION OF 2470 01:25:11,139 --> 01:25:12,807 TELEMEDICINE. 2471 01:25:12,874 --> 01:25:14,242 IT HAS BEEN INSPIRING TO WORK 2472 01:25:14,309 --> 01:25:16,244 WITH DR. GORDON BECAUSE OF HIS 2473 01:25:16,311 --> 01:25:18,379 COMMITMENT TO ADVANCING MENTAL 2474 01:25:18,446 --> 01:25:19,547 HEALTH AND IMPROVING PEOPLE'S 2475 01:25:19,614 --> 01:25:21,149 LIVES. 2476 01:25:21,216 --> 01:25:23,785 AND I AM DEEPLY GRATEFUL FOR HIS 2477 01:25:23,852 --> 01:25:25,253 EFFORTS TO LOOK -- AND I LOOK 2478 01:25:25,320 --> 01:25:27,422 FORWARD TO HIS CONTINUED 2479 01:25:27,489 --> 01:25:30,291 CONTRIBUTIONS AS HE RETURNS TO 2480 01:25:30,358 --> 01:25:31,226 COLUMBIA UNIVERSITY AND NEW YORK 2481 01:25:31,292 --> 01:25:33,061 CITY. 2482 01:25:33,127 --> 01:25:34,028 I APPRECIATE THE OPPORTUNITY TO 2483 01:25:34,095 --> 01:25:35,763 SPEAK WITH YOU TODAY, AND I'M 2484 01:25:35,830 --> 01:25:40,168 SORRY THAT BECAUSE OF MY 2485 01:25:40,235 --> 01:25:41,469 NECESSARY TRAVELS, I'M NOT ABLE 2486 01:25:41,536 --> 01:25:43,238 TO ATTEND IN PERSON AND ENGAGE 2487 01:25:43,304 --> 01:25:44,672 IN A DISCUSSION WITH ALL OF YOU. 2488 01:25:44,739 --> 01:25:46,574 I WISH YOU ALL A VERY PRODUCTIVE 2489 01:25:46,641 --> 01:25:46,808 MEETING. 2490 01:25:46,875 --> 01:25:50,378 THANK YOU. 2491 01:25:50,445 --> 01:25:55,750 [APPLAUSE] 2492 01:25:55,817 --> 01:25:57,485 >> I WANT TO THANK MONICA FOR 2493 01:25:57,552 --> 01:25:58,720 HER REMARKS AND THANK YOU ALL 2494 01:25:58,786 --> 01:26:00,889 FOR LISTENING. 2495 01:26:00,955 --> 01:26:02,090 UNLESS THERE ARE ANY COMMENTS 2496 01:26:02,156 --> 01:26:05,593 ABOUT THAT OR QUESTIONS FOR ME, 2497 01:26:05,660 --> 01:26:06,794 ON BEHALF OF DR. BERTAGNOLLI, 2498 01:26:06,861 --> 01:26:08,463 WE'RE GOING TO MOVE TOO A BREAK. 2499 01:26:08,530 --> 01:26:11,065 I'M GOING TO ASK ALL THE 2500 01:26:11,132 --> 01:26:11,966 COUNCILMEMBERS PRESENT TO COME 2501 01:26:12,033 --> 01:26:12,967 TO THE FRONT BECAUSE WE'RE GOING 2502 01:26:13,034 --> 01:26:13,835 TO GET A PHOTOGRAPH. 2503 01:26:13,902 --> 01:26:14,936 WE HAVEN'T DONE THAT IN A LITTLE 2504 01:26:15,003 --> 01:26:16,137 WHILE. 2505 01:26:16,204 --> 01:26:18,106 EVERYONE ELSE, WE CAN ADJOURN 2506 01:26:18,172 --> 01:26:28,049 AND RETURN AT 3:00. 2507 01:26:28,116 --> 01:26:33,187 THE NEXT ITEM ON OUR AGENDA IS A 2508 01:26:33,254 --> 01:26:34,522 REPORT FROM THE OFFICE OF 2509 01:26:34,589 --> 01:26:36,157 DISPARITIES RESEARCH AND 2510 01:26:36,224 --> 01:26:39,027 WORKFORCE DIVERSITY AT NIMH ON 2511 01:26:39,093 --> 01:26:40,228 PROGRESS IN THAT AREA. 2512 01:26:40,295 --> 01:26:44,499 PLEASE JOIN ME IN WELCOMING 2513 01:26:44,566 --> 01:26:46,467 DR. CHRISTINA BORBA TO OUR 2514 01:26:46,534 --> 01:26:48,102 MEETING, DIRECTOR OF THE NIMH 2515 01:26:48,169 --> 01:26:49,671 OFFICE FOR DISPARITIES RESEARCH 2516 01:26:49,737 --> 01:26:52,273 AND WORKFORCE DIVERSITY. 2517 01:26:52,340 --> 01:26:54,075 DR. BORBA JOINED NIMH IN 2518 01:26:54,142 --> 01:26:56,010 SEPTEMBER OF 2022. 2519 01:26:56,077 --> 01:26:57,545 WE ASKED HER TO COME SPEAK TO 2520 01:26:57,612 --> 01:26:59,080 COUNCIL TODAY TO SHARE BOTH HER 2521 01:26:59,147 --> 01:27:01,683 VISION FOR THE OFFICE AS WELL AS 2522 01:27:01,749 --> 01:27:03,685 PROVIDE INFORMATION ON THE 2523 01:27:03,751 --> 01:27:07,822 INITIATIVES THAT THE OFFICE AND 2524 01:27:07,889 --> 01:27:10,191 THE DISPARITIES TEAM ARE 2525 01:27:10,258 --> 01:27:11,059 PRIORITIZING. 2526 01:27:11,125 --> 01:27:13,361 THEY'VE ALREADY MADE SIGNIFICANT 2527 01:27:13,428 --> 01:27:15,863 PROGRESS UNDER DR. BORBA'S 2528 01:27:15,930 --> 01:27:16,965 LEADERSHIP, WHICH I THINK LU 2529 01:27:17,031 --> 01:27:17,966 APPRECIATE FROM HER PRESENTATION 2530 01:27:18,032 --> 01:27:20,602 TODAY. 2531 01:27:20,668 --> 01:27:21,703 CHRISTINA, PLEASE COME TO THE 2532 01:27:21,769 --> 01:27:31,913 PODIUM. 2533 01:27:40,154 --> 01:27:41,723 >> GOOD AFTERNOON, EVERYONE, AND 2534 01:27:41,789 --> 01:27:43,358 GOOD AFTERNOON, COUNCILMEMBERS 2535 01:27:43,424 --> 01:27:45,093 AND MY FELLOW NIMH STAFF 2536 01:27:45,159 --> 01:27:45,560 MEMBERS. 2537 01:27:45,627 --> 01:27:47,395 I AM REALLY EXCITED TO BE HERE 2538 01:27:47,462 --> 01:27:49,831 TODAY TO TALK ABOUT THE PROGRESS 2539 01:27:49,897 --> 01:27:51,466 THAT NOT ONLY THE OFFICE FOR 2540 01:27:51,532 --> 01:27:53,234 DISPARITIES RESEARCH AND 2541 01:27:53,301 --> 01:27:54,636 WORKFORCE DIVERSITY BUT ALSO THE 2542 01:27:54,702 --> 01:27:56,571 DISPARITIES TEAM AT NIMH HAS 2543 01:27:56,638 --> 01:27:59,641 MADE IN THE PAST COUPLE OF 2544 01:27:59,707 --> 01:28:04,245 YEARS. 2545 01:28:04,312 --> 01:28:05,346 WE'RE GOING TO GO THROUGH A 2546 01:28:05,413 --> 01:28:06,014 QUICK AGENDA. 2547 01:28:06,080 --> 01:28:07,181 WE'LL TALK A LITTLE BIT ABOUT 2548 01:28:07,248 --> 01:28:09,150 THE CURRENT STATE OF MENTAL 2549 01:28:09,217 --> 01:28:10,551 HEALTH DISPARITIES, THE HISTORY 2550 01:28:10,618 --> 01:28:12,687 OF ODWD, WHICH IS THE ACRONYM 2551 01:28:12,754 --> 01:28:13,755 FOR OUR OFFICE. 2552 01:28:13,821 --> 01:28:15,189 I'D LIKE TO INTRODUCE THE 2553 01:28:15,256 --> 01:28:17,925 CURRENT STAFF OF ODWD BECAUSE WE 2554 01:28:17,992 --> 01:28:19,627 HAVE, I THINK, DOUBLED OUR STAFF 2555 01:28:19,694 --> 01:28:22,463 IN THE PAST YEAR AND A HALF. 2556 01:28:22,530 --> 01:28:24,032 LOOK AT NIMH'S PRIORITIES FOR 2557 01:28:24,098 --> 01:28:26,200 MENTAL HEALTH DISPARITIES AND GO 2558 01:28:26,267 --> 01:28:29,437 THROUGH SOME KEY ACCOMPLISH 2559 01:28:29,504 --> 01:28:30,038 ACCOMPLISHMENTS, FUTURE 2560 01:28:30,104 --> 01:28:31,673 DIRECTIONS FOR ODWD, AND I WOULD 2561 01:28:31,739 --> 01:28:33,241 LOVE TO HAVE A DISCUSSION WITH 2562 01:28:33,307 --> 01:28:33,908 COUNCILMEMBERS IN TERMS OF NEXT 2563 01:28:33,975 --> 01:28:37,879 STEPS. 2564 01:28:37,945 --> 01:28:39,514 I DON'T NEED TO TELL THIS GROUP, 2565 01:28:39,580 --> 01:28:41,416 BUT WE STILL HAVE A MAJOR 2566 01:28:41,482 --> 01:28:42,283 PROBLEM WHEN WE'RE THINKING 2567 01:28:42,350 --> 01:28:43,017 ABOUT MENTAL HEALTH DISPARITIES 2568 01:28:43,084 --> 01:28:47,088 IN THIS COUNTRY. 2569 01:28:47,155 --> 01:28:48,456 THIS PARTICULAR STUDY CONDUCTED 2570 01:28:48,523 --> 01:28:53,895 FROM 2016 TO 2020 THAT LOOKED AT 2571 01:28:53,961 --> 01:28:56,330 WHAT WOULD BE THE COST AND ALSO 2572 01:28:56,397 --> 01:29:00,702 PREMATURE FOR HAVING LACK OF 2573 01:29:00,768 --> 01:29:01,836 MENTAL HEALTH EQUITY IN SERVICES 2574 01:29:01,903 --> 01:29:04,238 ROW SEARCH,RESEARCH. 2575 01:29:04,305 --> 01:29:05,273 I REALLY APPRECIATED THE 2576 01:29:05,339 --> 01:29:06,808 CONVERSATION EARLIER THIS 2577 01:29:06,874 --> 01:29:07,742 AFTERNOON AROUND MENTAL HEALTH 2578 01:29:07,809 --> 01:29:08,009 SERVICES. 2579 01:29:08,076 --> 01:29:10,545 AND THIS PARTICULAR STUDY LOOKED 2580 01:29:10,611 --> 01:29:14,282 AT ALSO RACE/ETHNICITY AND ALSO 2581 01:29:14,348 --> 01:29:15,616 INDIGENOUS POPULATIONS LIKE 2582 01:29:15,683 --> 01:29:17,418 AMERICAN INDIAN, ALASKA NATIVE 2583 01:29:17,485 --> 01:29:20,021 AND NATIVE HAWAIIAN, AND TOTAL 2584 01:29:20,088 --> 01:29:23,091 EXCESS PREMATURE DEATHS IS 2585 01:29:23,157 --> 01:29:25,693 116,000, WHICH COST US 2586 01:29:25,760 --> 01:29:26,027 $278 BILLION. 2587 01:29:26,094 --> 01:29:27,428 SO WE STILL HAVE A HUGE PROBLEM 2588 01:29:27,495 --> 01:29:28,963 WHEN WE'RE THINKING ABOUT MENTAL 2589 01:29:29,030 --> 01:29:31,232 HEALTH INEQUITIES IN THE UNITED 2590 01:29:31,299 --> 01:29:33,935 STATES. 2591 01:29:34,001 --> 01:29:35,169 I'D LIKE TO START WITH THE 2592 01:29:35,236 --> 01:29:36,137 DISPARITIES TEAM. 2593 01:29:36,204 --> 01:29:37,004 THE DISPARITIES TEAM WAS 2594 01:29:37,071 --> 01:29:39,373 DEVELOPED IN 2018 UNDER 2595 01:29:39,440 --> 01:29:40,541 DR. JOSHUA GORDON'S LEADERSHIP, 2596 01:29:40,608 --> 01:29:42,110 AND IT'S REALLY AN 2597 01:29:42,176 --> 01:29:43,945 INTERNAL-FACING TEAM THAT REALLY 2598 01:29:44,011 --> 01:29:46,314 GATHERS STAFF FROM ALL THE 2599 01:29:46,380 --> 01:29:50,051 DIVISIONS FROM OUR BASIC 2600 01:29:50,118 --> 01:29:50,918 SCIENCES, TRANSLATIONAL RESEARCH 2601 01:29:50,985 --> 01:29:51,986 AND ALSO INTERVENTION AND 2602 01:29:52,053 --> 01:29:54,155 SERVICES RESEARCH. 2603 01:29:54,222 --> 01:29:57,225 AND IT REALLY ALLOWS US TO WORK 2604 01:29:57,291 --> 01:29:58,359 TOGETHER IN THINKING ABOUT HOW 2605 01:29:58,426 --> 01:29:59,594 TO FURTHER THE MISSION WHEN 2606 01:29:59,660 --> 01:30:01,662 WE'RE THINKING ABOUT MENTAL 2607 01:30:01,729 --> 01:30:02,630 HEALTH DISPARITIES. 2608 01:30:02,697 --> 01:30:04,398 CURRENTLY OUR DISPARITIES TEAM 2609 01:30:04,465 --> 01:30:06,400 HAS OVER 60 MEMBERS ACROSS NIMH 2610 01:30:06,467 --> 01:30:08,503 AND THAT'S ALSO FROM THE 2611 01:30:08,569 --> 01:30:09,370 INTRAMURAL PROGRAM AS WELL. 2612 01:30:09,437 --> 01:30:11,239 AND WE DO MEET ON A MONTHLY 2613 01:30:11,305 --> 01:30:14,976 BASIS. 2614 01:30:15,042 --> 01:30:17,578 ODWD WAS ALSO CREATED UNDER 2615 01:30:17,645 --> 01:30:20,414 DR. JOSHUA GORDON IN 2020. 2616 01:30:20,481 --> 01:30:22,984 THIT'S DIRECTLY WITHIN THE OFFIE 2617 01:30:23,050 --> 01:30:25,620 OF THE DIRECTOR, AND ODWD REALLY 2618 01:30:25,686 --> 01:30:30,057 HAS TWO PREDOM N PREDOMINANT PR, 2619 01:30:30,124 --> 01:30:33,661 TO PROMOTE RESEARCH TO REDUCE 2620 01:30:33,728 --> 01:30:35,062 MENTAL HEALTH DISPARITIES AND 2621 01:30:35,129 --> 01:30:36,264 ADVANCE MENTAL HEALTH EQUITY AND 2622 01:30:36,330 --> 01:30:37,532 TO SUPPORT PROGRAMS TO DIVERSIFY 2623 01:30:37,598 --> 01:30:38,366 THE MENTAL HEALTH RESEARCH 2624 01:30:38,432 --> 01:30:39,467 WORKFORCE. 2625 01:30:39,534 --> 01:30:40,701 SO ODWD AND THE DISPARITIES TEAM 2626 01:30:40,768 --> 01:30:42,436 AS YOU IMAGINE WORK VERY CLOSELY 2627 01:30:42,503 --> 01:30:43,337 TOGETHER. 2628 01:30:43,404 --> 01:30:45,973 MYSELF AND DR. STACIA 2629 01:30:46,040 --> 01:30:47,175 FRIEDMAN-HILL CO-LEAD THE 2630 01:30:47,241 --> 01:30:48,042 DISPARITIES TEAM. 2631 01:30:48,109 --> 01:30:50,578 AND SO IT GIVES ME ABSOLUTE 2632 01:30:50,645 --> 01:30:52,413 PLEASURE TO INTRODUCE OUR OFFICE 2633 01:30:52,480 --> 01:30:55,316 THAT IS FULLY STAFFED NOW. 2634 01:30:55,383 --> 01:30:57,618 I'M CHRISTINA. 2635 01:30:57,685 --> 01:30:58,619 DR. LAUREN HILL, WHO IS SITTING 2636 01:30:58,686 --> 01:31:00,221 IN THE BACK, IS OUR DEPUTY 2637 01:31:00,288 --> 01:31:02,523 DIRECTOR FOR OUR OFFICE, SERVED 2638 01:31:02,590 --> 01:31:03,991 AS OUR ACTING DIRECTOR FOR THE 2639 01:31:04,058 --> 01:31:06,594 OFFICE FOR MANY YEARS PRIOR TO 2640 01:31:06,661 --> 01:31:09,564 MY ARRIVAL. 2641 01:31:09,630 --> 01:31:10,431 JING TRAN ALSO SITTING IN THE 2642 01:31:10,498 --> 01:31:12,400 BACK IS OUR NEW OPERATIONS 2643 01:31:12,466 --> 01:31:13,000 COORDINATOR. 2644 01:31:13,067 --> 01:31:15,236 SHE JUST MADE HER ONE-YEAR 2645 01:31:15,303 --> 01:31:16,103 ANNIVERSARY, AND I HAVE TO SAY 2646 01:31:16,170 --> 01:31:18,673 WITHOUT HER, I'M NOT SURE LAUREN 2647 01:31:18,739 --> 01:31:19,540 AND CHRISTINA WOULD BE ABLE TO 2648 01:31:19,607 --> 01:31:21,175 DO THEIR JOB. 2649 01:31:21,242 --> 01:31:23,911 MICHELLE LAY IS A SPECIAL 2650 01:31:23,978 --> 01:31:28,549 VOLUNTEER FOR ODWD, MASTERS OF 2651 01:31:28,616 --> 01:31:29,183 PUBLIC HEALTH STUDENT AT THE 2652 01:31:29,250 --> 01:31:31,752 UNIVERSITY OF MARYLAND. 2653 01:31:31,819 --> 01:31:33,421 RANDOMLY EMAILED ME AND ASKED IF 2654 01:31:33,487 --> 01:31:34,555 I WOULD BE INTERESTED IN TAKING 2655 01:31:34,622 --> 01:31:36,357 A STUDENT AND I SAID YES, AND 2656 01:31:36,424 --> 01:31:37,992 SHE SAID I WAS SO SURPRISED THAT 2657 01:31:38,059 --> 01:31:39,961 YOU EMAILED ME BACK. 2658 01:31:40,027 --> 01:31:41,596 AND SHE HAS ALSO BEEN WITH US 2659 01:31:41,662 --> 01:31:46,234 FOR OVER A YEAR AS WELL. 2660 01:31:46,300 --> 01:31:49,971 DR. JULIETTE MCCLENDON JOINED US 2661 01:31:50,037 --> 01:31:51,005 ABOUT EIGHT MONTHS AGO. 2662 01:31:51,072 --> 01:31:52,707 THEY ARE OUR PROGRAM DIRECTOR 2663 01:31:52,773 --> 01:31:53,875 FOR SOCIAL DETERMINANTS OF 2664 01:31:53,941 --> 01:31:55,109 MENTAL HEALTH DISPARITIES 2665 01:31:55,176 --> 01:31:57,411 RESEARCH. 2666 01:31:57,478 --> 01:31:58,379 DR. BESHAUN DAVIS IN THE BACK IS 2667 01:31:58,446 --> 01:31:59,647 ALSO NEW TO ODWD. 2668 01:31:59,714 --> 01:32:01,249 WE RECRUITED HIM ABOUT NINE 2669 01:32:01,315 --> 01:32:04,018 MONTHS AGO, AND IS OUR DIRECTOR 2670 01:32:04,085 --> 01:32:05,419 FOR MINORITY ADVERTISED 2671 01:32:05,486 --> 01:32:06,187 POPULATIONS MENTAL HEALTH 2672 01:32:06,254 --> 01:32:08,589 RESEARCH. 2673 01:32:08,656 --> 01:32:10,358 DR. BRITTANY HAYNES ALSO SITTING 2674 01:32:10,424 --> 01:32:11,592 IN THE BACK IS OUR PROGRAM 2675 01:32:11,659 --> 01:32:14,028 DIRECTOR FOR WORKFORCE DIVERSITY 2676 01:32:14,095 --> 01:32:17,732 AND EQUITY. 2677 01:32:17,798 --> 01:32:22,236 DR. TATIANA MEZA-CERVERA ALSO A 2678 01:32:22,303 --> 01:32:25,640 NEW RECRUIT AND OVERSEES OUR 2679 01:32:25,706 --> 01:32:28,676 DIVERSITY SUPPLEMENT AND YOUTH 2680 01:32:28,743 --> 01:32:29,310 MENTAL HEALTH RESEARCH AND 2681 01:32:29,377 --> 01:32:31,445 THERE'S MORE. 2682 01:32:31,512 --> 01:32:33,381 TAMARA LEWIS JOHNSON OVERSEES 2683 01:32:33,447 --> 01:32:34,148 OUR WOMEN'S MENTAL HEALTH 2684 01:32:34,215 --> 01:32:35,049 RESEARCH PROGRAM AND IS ALSO 2685 01:32:35,116 --> 01:32:36,751 HERE TODAY WITH US. 2686 01:32:36,817 --> 01:32:39,253 DR. DAWN MORALES OVERSEES OUR 2687 01:32:39,320 --> 01:32:40,922 RURAL MENTAL HEALTH RESEARCH, 2688 01:32:40,988 --> 01:32:42,089 AMERICAN INDIAN AND ALASKA 2689 01:32:42,156 --> 01:32:42,957 NATIVE MENTAL HEALTH RESEARCH, 2690 01:32:43,024 --> 01:32:46,460 AND DR. JENNIFER VILLATTE 2691 01:32:46,527 --> 01:32:47,495 OVERSEES OUR COMPASS PROGRAM, 2692 01:32:47,561 --> 01:32:50,765 WHICH YOU GUYS HAVE HEARD ABOUT, 2693 01:32:50,831 --> 01:32:52,867 AND ALSO WORKS ON OUR COMMUNITY 2694 01:32:52,934 --> 01:32:54,802 ENGAGEMENT HEALTH RESEARCH 2695 01:32:54,869 --> 01:32:56,203 INITIATIVES AS WELL. 2696 01:32:56,270 --> 01:33:01,976 SO A VERY FULL OFFICE AND 2697 01:33:02,043 --> 01:33:02,543 UNBELIEVABLE EXPERTISE. 2698 01:33:02,610 --> 01:33:04,211 SO IT GIVES ME GREAT PLEASURE TO 2699 01:33:04,278 --> 01:33:08,683 REALLY TALK ABOUT QH WHAT WE'VE 2700 01:33:08,749 --> 01:33:10,952 BEEN WORKING ON FOR THE PAST 2701 01:33:11,018 --> 01:33:12,320 YEAR AND A HALF. 2702 01:33:12,386 --> 01:33:13,554 NIMH JUST RECENTLY REVISED OUR 2703 01:33:13,621 --> 01:33:14,789 PRIORITY AREAS FOR MENTAL HEALTH 2704 01:33:14,855 --> 01:33:15,256 DISPARITIES RESEARCH. 2705 01:33:15,323 --> 01:33:16,757 THIS WILL BE UPDATED ON THE 2706 01:33:16,824 --> 01:33:19,226 WEBSITE IN THE COMING WEEKS. 2707 01:33:19,293 --> 01:33:20,528 THIS WAS IN COLLABORATION WITH 2708 01:33:20,594 --> 01:33:21,629 THE DISPARITIES TEAM. 2709 01:33:21,696 --> 01:33:23,998 WE DEVELOPED A STEERING 2710 01:33:24,065 --> 01:33:25,299 COMMITTEE TO REALLY THINK ABOUT 2711 01:33:25,366 --> 01:33:27,268 WHERE SHOULD WE BE GOING IN THE 2712 01:33:27,335 --> 01:33:31,472 NEXT ONE, THREE, FIVE, 10 YEARS 2713 01:33:31,539 --> 01:33:32,039 WHILE WE'RE THINKING ABOUT 2714 01:33:32,106 --> 01:33:32,606 MENTAL HEALTH DISPARITIES. 2715 01:33:32,673 --> 01:33:35,343 THESE ARE OUR FIVE TOP PRIORITY 2716 01:33:35,409 --> 01:33:36,210 AREAS. 2717 01:33:36,277 --> 01:33:37,812 THE PRIORITY AREA ONE AND TWO 2718 01:33:37,878 --> 01:33:42,216 ARE AT THE TOP ACTUALLY FOR A 2719 01:33:42,283 --> 01:33:43,184 REASON, REALLY THINKING ABOUT 2720 01:33:43,250 --> 01:33:44,285 BUILDING RESEARCH CAPACITY AND 2721 01:33:44,352 --> 01:33:45,886 THINKING ABOUT NOT JUST RESEARCH 2722 01:33:45,953 --> 01:33:48,723 CAPACITY AT THE INDIVIDUAL LEVEL 2723 01:33:48,789 --> 01:33:50,057 WHEN IT COMES TO TRAINING THE 2724 01:33:50,124 --> 01:33:51,025 NEXT GENERATION, BUT ALSO 2725 01:33:51,092 --> 01:33:52,293 THINKING ABOUT CAPACITY BUILDING 2726 01:33:52,360 --> 01:33:56,864 IN OUR INSTITUTIONS AND HAVING 2727 01:33:56,931 --> 01:33:58,399 MORE GEOGRAPHIC DIVERSITY IN OUR 2728 01:33:58,466 --> 01:34:01,535 PORTFOLIO AT NIMH. 2729 01:34:01,602 --> 01:34:02,603 REALLY THINKING ABOUT COMMUNITY 2730 01:34:02,670 --> 01:34:04,238 ENGAGED RESEARCH, WHO DO WE HAVE 2731 01:34:04,305 --> 01:34:06,240 AT THE TABLE AT ALL STAGES OF 2732 01:34:06,307 --> 01:34:07,508 RESEARCH. 2733 01:34:07,575 --> 01:34:09,043 HOW ARE OUR RESEARCH QUESTIONS 2734 01:34:09,110 --> 01:34:10,411 ASKED, HOW ARE THEY ANALYZED, 2735 01:34:10,478 --> 01:34:12,613 HOW ARE THEY DISSEMINATED BACK 2736 01:34:12,680 --> 01:34:13,280 TO THE COMMUNITY. 2737 01:34:13,347 --> 01:34:14,382 AND SO THINKING ABOUT ALL THE 2738 01:34:14,448 --> 01:34:17,084 WORK THAT WE DO AT NIMH, 2739 01:34:17,151 --> 01:34:18,152 CAPACITY BUILDING AND COMMUNITY 2740 01:34:18,219 --> 01:34:19,587 ENGAGED RESEARCH REALLY BUBBLES 2741 01:34:19,653 --> 01:34:23,824 TO THE TOP AS OUR PRIORITIES. 2742 01:34:23,891 --> 01:34:25,226 PRIORITY AREA THREE IS 2743 01:34:25,292 --> 01:34:26,627 IDENTIFYING MECHANISMS BY WHICH 2744 01:34:26,694 --> 01:34:27,962 MENTAL HEALTH DISPARITIES ARISE 2745 01:34:28,029 --> 01:34:31,232 AND PERSIST. 2746 01:34:31,298 --> 01:34:32,466 AND ADVANCE IMPLEMENTATION 2747 01:34:32,533 --> 01:34:34,301 SCIENCE TO REDUCE OR ELIMINATE 2748 01:34:34,368 --> 01:34:35,569 MENTAL HEALTH DISPARITIES, AND 2749 01:34:35,636 --> 01:34:37,438 THEN PRIORITY AREA FIVE IS 2750 01:34:37,505 --> 01:34:39,140 SUPPORT RESEARCH ON INTEGRATED 2751 01:34:39,206 --> 01:34:40,574 CARE MODELS, AND THAT'S REALLY 2752 01:34:40,641 --> 01:34:41,876 LOOKING AT OTHER SETTINGS LIKE 2753 01:34:41,942 --> 01:34:43,677 THE SCHOOL SETTING, OUR 2754 01:34:43,744 --> 01:34:44,478 FAITH-BASED ORGANIZATION AND 2755 01:34:44,545 --> 01:34:45,579 OTHER COMMUNITY-BASED 2756 01:34:45,646 --> 01:34:51,185 ORGANIZATIONS AS WELL. 2757 01:34:51,252 --> 01:34:52,953 SO SINCE I ONLY HAVE LIMITED 2758 01:34:53,020 --> 01:34:54,388 TIME I CANNOT GO OVER ALL OF OUR 2759 01:34:54,455 --> 01:34:56,390 KEY ACCOMPLISHMENTS, BUT THESE 2760 01:34:56,457 --> 01:34:57,892 ARE THE TOP ACCOMPLISHMENTS THAT 2761 01:34:57,958 --> 01:34:59,060 I REALLY WANTED TO SHARE WITH 2762 01:34:59,126 --> 01:35:00,494 COUNCIL TODAY AND REALLY OUR 2763 01:35:00,561 --> 01:35:02,463 PROGRESS IN SOCIAL DETERMINANTS 2764 01:35:02,530 --> 01:35:04,131 OF HEALTH, HOW NIH HAS RECENTLY 2765 01:35:04,198 --> 01:35:09,170 DEG DESIGNATED PEOPLE WITH 2766 01:35:09,236 --> 01:35:10,071 DISABILITY AS A DISPARITY 2767 01:35:10,137 --> 01:35:11,639 POPULATION. 2768 01:35:11,705 --> 01:35:13,774 RESEARCH WORKFORCE DIVERSITY, 2769 01:35:13,841 --> 01:35:14,975 OUR DIVERSITY SUPPLEMENT 2770 01:35:15,042 --> 01:35:17,144 PROGRAM, WHAT WE'RE DOING IN 2771 01:35:17,211 --> 01:35:17,878 WOMEN'S MENTAL HEALTH, RURAL 2772 01:35:17,945 --> 01:35:18,913 MENTAL HEALTH AND A LITTLE ABOUT 2773 01:35:18,979 --> 01:35:19,980 THE COMPASS AND COMMUNITY 2774 01:35:20,047 --> 01:35:21,348 ENGAGEMENT. 2775 01:35:21,415 --> 01:35:24,418 SO FIRST IN TERMS OF LIEDER SHIP 2776 01:35:24,485 --> 01:35:26,854 AND SOCIAL DETERMINANTS OF 2777 01:35:26,921 --> 01:35:28,355 HEALTH, NIMH HAS TAKEN A 2778 01:35:28,422 --> 01:35:29,957 LEADERSHIP ROLE IN SEVERAL 2779 01:35:30,024 --> 01:35:33,961 DIFFERENT FUNDING ANNOU ANNOUNC. 2780 01:35:34,028 --> 01:35:35,062 THESE ARE ALL LINKED BY THE WAY 2781 01:35:35,129 --> 01:35:36,530 IF YOU WANT TO TAKE A LOOK. 2782 01:35:36,597 --> 01:35:39,600 SO LOOKING AT SOCIAL 2783 01:35:39,667 --> 01:35:40,234 DISCONNECTION AND SUICIDE RISK 2784 01:35:40,301 --> 01:35:42,369 IN LATE LIFE, WE KNOW THAT THE 2785 01:35:42,436 --> 01:35:43,404 U.S. SURGEON GENERAL HAS TALKED 2786 01:35:43,471 --> 01:35:45,573 ABOUT SOCIAL ISOLATION AS A 2787 01:35:45,639 --> 01:35:48,909 MAJOR PUBLIC HEALTH PROBLEM. 2788 01:35:48,976 --> 01:35:50,644 WE ALSO ARE LOOKING AT STIGMA 2789 01:35:50,711 --> 01:35:53,914 AND DISCRIMINATION IN HIV 2790 01:35:53,981 --> 01:35:54,682 PREVENTION AND TREATMENT AND 2791 01:35:54,748 --> 01:35:55,883 THEN IN COLLABORATION WITH NIMH 2792 01:35:55,950 --> 01:35:58,252 AS THE LEAD, STILL LOOKING AT 2793 01:35:58,319 --> 01:35:59,720 COVID-19 AND THE SOCIAL 2794 01:35:59,787 --> 01:36:02,123 BEHAVIORAL AND ECONOMIC IMPACT 2795 01:36:02,189 --> 01:36:03,390 OF COVID-19 IN OUR UNDERSERVED 2796 01:36:03,457 --> 01:36:06,260 AND VULNERABLE POPULATIONS. 2797 01:36:06,327 --> 01:36:09,330 WE, TOO, HAVE AN RFI. 2798 01:36:09,396 --> 01:36:11,665 AND WHICH CLOSES TODAY AT 2799 01:36:11,732 --> 01:36:13,601 11:59 P.M. 2800 01:36:13,667 --> 01:36:14,835 SO WHEN WE'RE DONE HERE, 2801 01:36:14,902 --> 01:36:15,803 EVERYONE CAN FILL THIS OUT. 2802 01:36:15,870 --> 01:36:18,205 BUT REALLY LOOKING AT MOVING 2803 01:36:18,272 --> 01:36:19,807 BEYOND THE INDIVIDUAL LEVEL 2804 01:36:19,874 --> 01:36:21,108 DETERMINANTS OF MENTAL HEALTH TO 2805 01:36:21,175 --> 01:36:22,643 ADDRESS MENTAL HEALTH 2806 01:36:22,710 --> 01:36:24,278 DISPARITIES, REALLY LOOKING TO 2807 01:36:24,345 --> 01:36:25,546 IDENTIFY THE DETERMINANTS OF 2808 01:36:25,613 --> 01:36:27,414 MENTAL HEALTH DISPARITIES BEYOND 2809 01:36:27,481 --> 01:36:29,049 THAT INDIVIDUAL LEVEL AT THE 2810 01:36:29,116 --> 01:36:30,918 SOCIAL, SYSTEMIC AND STRUCTURAL 2811 01:36:30,985 --> 01:36:32,753 LEVELS, AND THEN DEVELOPING 2812 01:36:32,820 --> 01:36:35,055 CULTURALLY RESPONSIVE AND 2813 01:36:35,122 --> 01:36:35,923 MULTI-LEVEL INTERVENTIONS TO 2814 01:36:35,990 --> 01:36:36,891 ADDRESS MENTAL HEALTH 2815 01:36:36,957 --> 01:36:37,224 DISPARITIES. 2816 01:36:37,291 --> 01:36:40,261 LIKE I SAID IT CLOSES TODAY AT 2817 01:36:40,327 --> 01:36:41,162 11:59, AND REALLY LOOKING 2818 01:36:41,228 --> 01:36:42,663 FORWARD TO THE RESPONSE FROM THE 2819 01:36:42,730 --> 01:36:46,400 COMMUNITY. 2820 01:36:46,467 --> 01:36:47,801 WE ALSO HAVE BEEN SPENDING A LOT 2821 01:36:47,868 --> 01:36:50,104 OF TIME COLLABORATING ACROSS 2822 01:36:50,171 --> 01:36:54,608 NIH, AND WE HAVE SPENT A LOT OF 2823 01:36:54,675 --> 01:36:56,777 TIME REALLY GETTING TO KNOW WHAT 2824 01:36:56,844 --> 01:36:57,745 OTHER INSTITUTES AND CENTERS ARE 2825 01:36:57,811 --> 01:36:58,846 WORKING ON WHEN IT COMES TO 2826 01:36:58,913 --> 01:37:00,881 SOCIAL DETERMINANTS OF HEALTH. 2827 01:37:00,948 --> 01:37:02,116 AND WE'RE REALLY HAPPY TO SAY 2828 01:37:02,183 --> 01:37:03,517 THAT WE'VE BEEN ABLE TO SIGN ON 2829 01:37:03,584 --> 01:37:06,253 TO SEVERAL FUNDING ANNOUNCEMENTS 2830 01:37:06,320 --> 01:37:11,158 FROM NCI, NIMHD, NINR AND NHLBI 2831 01:37:11,225 --> 01:37:13,227 LOOKING AT STRUCTURAL RACISM AND 2832 01:37:13,294 --> 01:37:16,297 DISCRIMINATION, LOOKING AT SGM 2833 01:37:16,363 --> 01:37:20,100 POPULATIONS, COMMUNITY-BASED -- 2834 01:37:20,167 --> 01:37:21,101 COMMUNITY-ENGAGED RESEARCH, AND 2835 01:37:21,168 --> 01:37:26,140 SO WE FEEL WITH JULIETTE 2836 01:37:26,207 --> 01:37:27,074 MCCLENDON'S LEADERSHIP, WE'VE 2837 01:37:27,141 --> 01:37:28,409 REALLY BEEN ABLE TO COLLABORATE 2838 01:37:28,475 --> 01:37:29,743 NOW ACROSS NIH IN TERMS OF OTHER 2839 01:37:29,810 --> 01:37:34,982 FUNDING OPPORTUNITIES. 2840 01:37:35,049 --> 01:37:37,151 NEXT WEEK, ON JUNE 6TH, WE HAVE 2841 01:37:37,218 --> 01:37:39,320 A ONE-DAY VIRTUAL WORKSHOP, 2842 01:37:39,386 --> 01:37:40,421 DISCRIMINATION AS A SOCIAL 2843 01:37:40,487 --> 01:37:41,055 DETERMINANT OF MENTAL HEALTH 2844 01:37:41,121 --> 01:37:43,324 DISPARITIES. 2845 01:37:43,390 --> 01:37:46,627 I HAVE A "REGISTER HERE" AT THE 2846 01:37:46,694 --> 01:37:46,927 BOTTOM. 2847 01:37:46,994 --> 01:37:48,329 WE ARE AT A WAIT LIST BECAUSE 2848 01:37:48,395 --> 01:37:49,363 WE'VE REACHED 5,000 2849 01:37:49,430 --> 01:37:52,399 REGISTRATIONS. 2850 01:37:52,466 --> 01:37:53,734 WE MADE 2,000 REGISTRATIONS 2851 01:37:53,801 --> 01:37:55,369 WITHIN THE FIRST HOUR AND HAD TO 2852 01:37:55,436 --> 01:37:57,404 OPEN UP OUR REGISTRATION TO 2853 01:37:57,471 --> 01:37:58,939 3,000 AND THEN FOUR AND THEN 2854 01:37:59,006 --> 01:38:01,342 FINALLY THE CONTRACTOR SAYS YOU 2855 01:38:01,408 --> 01:38:01,976 HAVE 5,000 MAX. 2856 01:38:02,042 --> 01:38:04,178 AND WE NOW HAVE EMAILS COMING IN 2857 01:38:04,245 --> 01:38:05,779 AS OF THIS MORNING BEING LIKE, 2858 01:38:05,846 --> 01:38:07,114 IS THERE A WAIT LIST? 2859 01:38:07,181 --> 01:38:08,315 BECAUSE WE REALLY WANT TO 2860 01:38:08,382 --> 01:38:09,483 PARTICIPATE IN THIS. 2861 01:38:09,550 --> 01:38:11,485 AND SO WE HAVE WORKED WITH OUR 2862 01:38:11,552 --> 01:38:12,987 CONTRACTOR TO NOW DEVELOP A WAIT 2863 01:38:13,053 --> 01:38:17,324 LIST TO ALLOW PEOPLE IN ON JUN 2864 01:38:17,391 --> 01:38:18,859 JUNE 6TH AND ONCE WE GET TO THAT 2865 01:38:18,926 --> 01:38:19,927 5,000 CAP, OBVIOUSLY WE'RE AT 2866 01:38:19,994 --> 01:38:22,596 THE CAP. 2867 01:38:22,663 --> 01:38:24,098 THIS TO ME SIGNALS A HUGE 2868 01:38:24,164 --> 01:38:28,369 INTEREST FROM THE FIELD, AND 2869 01:38:28,435 --> 01:38:29,903 IT'S A NUMBER THAT I DON'T THINK 2870 01:38:29,970 --> 01:38:31,372 NIMH HAS SEEN BEFORE IN TERMS OF 2871 01:38:31,438 --> 01:38:33,707 5,000 PEOPLE REGISTERING FOR A 2872 01:38:33,774 --> 01:38:35,242 ONE-DAY WORKSHOP, AND SO WE'RE 2873 01:38:35,309 --> 01:38:37,278 REALLY EXCITED. 2874 01:38:37,344 --> 01:38:40,781 WE HAVE A FULL DAY OF AMAZING 2875 01:38:40,848 --> 01:38:43,751 SPEAKERS AND BREAKOUT ROOMS AS 2876 01:38:43,817 --> 01:38:45,286 WELL, SO YOU CAN REGISTER HERE 2877 01:38:45,352 --> 01:38:46,453 OR EMAIL ME AND I WILL ADD YOU 2878 01:38:46,520 --> 01:38:48,389 TO THE WAIT LIST IF YOU HAVE NOT 2879 01:38:48,455 --> 01:38:51,492 REGISTERED YET. 2880 01:38:51,558 --> 01:38:53,360 SO I'M MOVING ON TO DISABILITY 2881 01:38:53,427 --> 01:38:55,429 RESEARCH AT NIMH. 2882 01:38:55,496 --> 01:38:59,800 IN SEPTEMBER OF 2023, NIH 2883 01:38:59,867 --> 01:39:01,101 DESIGNATED PEOPLE WITH 2884 01:39:01,168 --> 01:39:01,969 DISABILITIES AS A HEALTH 2885 01:39:02,036 --> 01:39:03,671 DISPARITIES POPULATION IN 2886 01:39:03,737 --> 01:39:06,473 RESEARCH. 2887 01:39:06,540 --> 01:39:08,542 AND UNDER DR. DAVIS' LEADERSHIP, 2888 01:39:08,609 --> 01:39:09,677 HE DEVELOPED A TASK FORCE IN 2889 01:39:09,743 --> 01:39:11,512 NOVEMBER OF 2023 TO REALLY THINK 2890 01:39:11,578 --> 01:39:13,447 ABOUT AND DEFINE WHAT ARE OUR 2891 01:39:13,514 --> 01:39:17,451 RESEARCH PRIORITIES REGARDING 2892 01:39:17,518 --> 01:39:19,486 THE INTERSECTION OF DISABILITY 2893 01:39:19,553 --> 01:39:20,154 AND MENTAL ILLNESS. 2894 01:39:20,220 --> 01:39:21,588 BASED ON THAT TASK FORCE, WE 2895 01:39:21,655 --> 01:39:24,458 WERE ABLE TO -- HE UNDER HIS 2896 01:39:24,525 --> 01:39:25,626 LEADERSHIP WAS ABLE TO 2897 01:39:25,693 --> 01:39:31,065 COORDINATE THE SIGNING ON TO 2898 01:39:31,131 --> 01:39:31,598 NIMHD'S NOTICE OF FUNDING 2899 01:39:31,665 --> 01:39:32,266 OPPORTUNITY ON HEALTH AND 2900 01:39:32,333 --> 01:39:33,367 HEALTHCARE DISPARITIES AMONG 2901 01:39:33,434 --> 01:39:36,270 PEOPLE LIVING WITH DISABILITIES. 2902 01:39:36,337 --> 01:39:36,937 THIS PARTICULAR FUNDING 2903 01:39:37,004 --> 01:39:38,038 ANNOUNCEMENT REALLY LOOKS AT THE 2904 01:39:38,105 --> 01:39:40,641 INTERSECTION OF RACE, ETHNICITY, 2905 01:39:40,708 --> 01:39:42,076 AND SOCIOECONOMIC STATUS WHEN IT 2906 01:39:42,142 --> 01:39:44,244 COMES TO THE HEALTH OF PEOPLE 2907 01:39:44,311 --> 01:39:49,616 EXPERIENCING A DISABILITY. 2908 01:39:49,683 --> 01:39:52,720 ADDITIONALLY UNDER DR. BESHAUN 2909 01:39:52,786 --> 01:39:54,855 DAVIS' LEADERSHIP HE IS 2910 01:39:54,922 --> 01:39:56,523 PREPARING A SERIES THIS AUGUST 2911 01:39:56,590 --> 01:39:58,359 INTO FEBRUARY OF 2025 REALLY 2912 01:39:58,425 --> 01:40:00,461 THINKING ABOUT WHAT IS NIMH'S 2913 01:40:00,527 --> 01:40:02,429 ROLE IN THIS SPACE, BUT ONE OF 2914 01:40:02,496 --> 01:40:05,065 THE KEY THEMES OF THESE WEBINAR 2915 01:40:05,132 --> 01:40:05,966 SERIES IS PEOPLE WITH LIVED 2916 01:40:06,033 --> 01:40:06,934 EXPERIENCE, SO WE'RE OPENING UP 2917 01:40:07,000 --> 01:40:09,103 THE WEBINAR SERIES WITH PEOPLE 2918 01:40:09,169 --> 01:40:10,604 WITH LIVED EXPERIENCE AND THEN 2919 01:40:10,671 --> 01:40:11,972 CLOSING IT OUT AS WELL WITH 2920 01:40:12,039 --> 01:40:16,810 PEOPLE WITH LIVED EXPERIENCE. 2921 01:40:16,877 --> 01:40:18,946 SO NOW I WANT TO BRING US TO 2922 01:40:19,012 --> 01:40:19,847 WORKFORCE DIVERSITY AT NIMH, AND 2923 01:40:19,913 --> 01:40:24,752 THIS IS UNDER DR. BRI TSM TANY 2924 01:40:24,818 --> 01:40:25,853 HAYNES LEADERSHIP AS WELL. 2925 01:40:25,919 --> 01:40:28,455 OUR PROGRAM REALLY COORDINATES 2926 01:40:28,522 --> 01:40:29,690 NIMH RESEARCH WORKFORCE 2927 01:40:29,757 --> 01:40:31,358 DIVERSITY INITIATIVES, PROMOTES 2928 01:40:31,425 --> 01:40:32,793 EQUITY IN THE MENTAL HEALTH 2929 01:40:32,860 --> 01:40:35,729 RESEARCH WORKFORCE, AND 2930 01:40:35,796 --> 01:40:39,299 DR. HAYNES REALLY WORKS ACROSS 2931 01:40:39,366 --> 01:40:41,068 NIH UNDER UNITE AND ALL THE 2932 01:40:41,135 --> 01:40:43,771 UNITE INITIATIVES AND 2933 01:40:43,837 --> 01:40:44,972 OPPORTUNITIES FOR BOTH 2934 01:40:45,038 --> 01:40:45,873 INSTITUTIONAL FUNDING 2935 01:40:45,939 --> 01:40:47,241 OPPORTUNITIES FOR WORKFORCE 2936 01:40:47,307 --> 01:40:49,643 DIVERSITY BUT ALSO INDIVIDUAL 2937 01:40:49,710 --> 01:40:51,178 TRAINING. 2938 01:40:51,245 --> 01:40:52,413 WHAT I LOVE IS THIS FIGURE THAT 2939 01:40:52,479 --> 01:40:53,714 REALLY SHOWS THE PROGRESS THAT 2940 01:40:53,781 --> 01:40:55,215 WE'VE MADE IN TERMS OF SIGNING 2941 01:40:55,282 --> 01:40:59,820 ON TO DIFFERENT OPPORTUNITIES ON 2942 01:40:59,887 --> 01:41:00,888 ALL THE DIFFERENT CAREER STAGES 2943 01:41:00,954 --> 01:41:03,624 FROM UNDERGRAD, PREDOCTORAL, 2944 01:41:03,690 --> 01:41:04,958 POSTDOCTORAL AND FACULTY LEVEL, 2945 01:41:05,025 --> 01:41:06,827 BUT ALSO AT THE INSTITUTIONAL 2946 01:41:06,894 --> 01:41:07,995 LEVEL, REALLY THINKING ABOUT 2947 01:41:08,061 --> 01:41:10,931 THAT RESEARCH CAPACITY BUILDING 2948 01:41:10,998 --> 01:41:12,266 OPPORTUNITIES FOR OUR 2949 01:41:12,332 --> 01:41:13,033 INSTITUTIONS. 2950 01:41:13,100 --> 01:41:16,003 AND SO THESE ARE ALSO ALL LINKED 2951 01:41:16,069 --> 01:41:17,304 AS WELL IF ANY ONE IS 2952 01:41:17,371 --> 01:41:21,775 INTERESTED. 2953 01:41:21,842 --> 01:41:25,345 ADDITIONALLY UNDER BRITTANY 2954 01:41:25,412 --> 01:41:26,680 HAYNES' LEADERSHIP, SHE 2955 01:41:26,747 --> 01:41:27,681 DEVELOPED A SPECIAL INTEREST 2956 01:41:27,748 --> 01:41:29,850 GROUP WITHIN NIMH TO PROMOTE 2957 01:41:29,917 --> 01:41:31,718 DIVERSITY IN THE NIMH EXTRAMURAL 2958 01:41:31,785 --> 01:41:34,888 AND INTRAMURAL RESEARCH 2959 01:41:34,955 --> 01:41:36,423 WORKFORCE THROUGH OUTREACH WITH 2960 01:41:36,490 --> 01:41:37,491 A PARTICULAR INTEREST IN 2961 01:41:37,558 --> 01:41:38,659 BROADENING THE ANTICIPATION IN 2962 01:41:38,725 --> 01:41:40,327 INCLUSION OF TRAINEES AND 2963 01:41:40,394 --> 01:41:40,994 INVESTIGATORS FROM GROUPS THAT 2964 01:41:41,061 --> 01:41:44,565 HAVE BEEN TRADITIONALLY 2965 01:41:44,631 --> 01:41:45,199 UNDERREPRESENTED IN THE MENTAL 2966 01:41:45,265 --> 01:41:46,967 HEALTH RESEARCH WORKFORCE. 2967 01:41:47,034 --> 01:41:47,935 SO THIS PARTICULAR SPECIAL 2968 01:41:48,001 --> 01:41:49,069 INTEREST GROUP IS REALLY AN 2969 01:41:49,136 --> 01:41:51,205 OPPORTUNITY FOR US TO SHARE OUR 2970 01:41:51,271 --> 01:41:54,808 KNOWLEDGE ACROSS THE I.C., 2971 01:41:54,875 --> 01:41:55,809 REALLY THINKING ABOUT 2972 01:41:55,876 --> 01:41:57,244 STRATEGIES, EXISTING RESOURCES, 2973 01:41:57,311 --> 01:42:02,716 BEST PRACTICES THAT PEOPLE HAVE. 2974 01:42:02,783 --> 01:42:03,684 SHE'S LOOKING TO DEVELOP A SET 2975 01:42:03,750 --> 01:42:05,118 OF SHARED RESOURCES WE CAN ALL 2976 01:42:05,185 --> 01:42:06,320 USE AS WE'RE THINKING ABOUT 2977 01:42:06,386 --> 01:42:09,923 OUTREACH TO THE COMMUNITY, AND 2978 01:42:09,990 --> 01:42:11,091 THEN REALLY THINKING ABOUT 2979 01:42:11,158 --> 01:42:12,793 TRACKING AND EVALUATING OUR 2980 01:42:12,860 --> 01:42:15,062 OUTREACH ACTIVITIES AS WE MOVE 2981 01:42:15,128 --> 01:42:19,433 FORWARD. 2982 01:42:19,500 --> 01:42:24,404 SO DR. TATIANA WHO'S ALSO HERE 2983 01:42:24,471 --> 01:42:26,106 TODAY CAME FROM OUR IRP PROGRAM, 2984 01:42:26,173 --> 01:42:27,508 SHE JOINED US ALSO ABOUT A YEAR 2985 01:42:27,574 --> 01:42:30,878 AGO AND HAS T TAKEN OVER THE 2986 01:42:30,944 --> 01:42:33,547 LEADERSHIP OF THE DIVERSITY 2987 01:42:33,614 --> 01:42:34,147 SUPPLEMENT PROGRAM. 2988 01:42:34,214 --> 01:42:35,582 AS YOU CAN SEE FROM THE LINES, 2989 01:42:35,649 --> 01:42:36,750 WE HAVE BEEN QUITE SUCCESSFUL, 2990 01:42:36,817 --> 01:42:39,820 AND I WOULD LIKE TO SAY A VERY 2991 01:42:39,887 --> 01:42:41,588 BIG THANK YOU TO OUR TRAINING 2992 01:42:41,655 --> 01:42:43,090 TEAM HERE AT NIMH. 2993 01:42:43,156 --> 01:42:44,958 THE AMOUNT OF TECHNICAL 2994 01:42:45,025 --> 01:42:47,261 ASSISTANCE THE TRAINING TEAM HAS 2995 01:42:47,327 --> 01:42:48,328 PROVIDED HAS BEEN OUTSTANDING 2996 01:42:48,395 --> 01:42:49,997 AND WE CAN SEE THE DIRECT IMPACT 2997 01:42:50,063 --> 01:42:53,367 OF THAT TECHNICAL ASSISTANCE. 2998 01:42:53,433 --> 01:42:55,536 NOT ONLY HAS OUR NUMBER OF 2999 01:42:55,602 --> 01:42:56,236 APPLICATIONS REALLY STEADILY 3000 01:42:56,303 --> 01:42:57,538 INCREASED, BUT ALSO THE SUCCESS 3001 01:42:57,604 --> 01:42:59,506 RATE AS WELL. 3002 01:42:59,573 --> 01:43:01,408 AND SO IN OUR CURRENT FISCAL 3003 01:43:01,475 --> 01:43:03,710 YEAR OF 2023, SO OUR PREVIOUS 3004 01:43:03,777 --> 01:43:06,747 FISCAL YEAR, 95 APPLICATIONS FOR 3005 01:43:06,813 --> 01:43:07,915 THE DIVERSITY SUPPLEMENT 3006 01:43:07,981 --> 01:43:09,550 PROGRAM, WE AWARDED 79 WHICH IS 3007 01:43:09,616 --> 01:43:12,252 A SUCCESS RATE OF 83.2%, AND 3008 01:43:12,319 --> 01:43:13,186 THAT'S REALLY BECAUSE OF 3009 01:43:13,253 --> 01:43:14,221 TECHNICAL ASSISTANCE THE 3010 01:43:14,288 --> 01:43:16,456 TRAINING TEAM PROVIDES AND ALSO 3011 01:43:16,523 --> 01:43:18,425 TATIANA AS WELL IN REALLY MAKING 3012 01:43:18,492 --> 01:43:21,028 SURE THAT MENTEES AND MENTORS 3013 01:43:21,094 --> 01:43:23,664 ARE PRODUCING REALLY HIGH 3014 01:43:23,730 --> 01:43:24,765 QUALITY APPLICATIONS. 3015 01:43:24,831 --> 01:43:28,035 AND ALSO PART OF THAT SPECIAL 3016 01:43:28,101 --> 01:43:29,870 INTEREST GROUP WITH BRITTANY IS 3017 01:43:29,937 --> 01:43:31,171 REALLY HOW DO WE START REACHING 3018 01:43:31,238 --> 01:43:32,506 OUT TO THOSE INSTITUTIONS WHO 3019 01:43:32,573 --> 01:43:33,607 OTHERWISE WOULD BE HESITANT TO 3020 01:43:33,674 --> 01:43:35,108 APPLY FOR A DIVERSITY SUPPLEMENT 3021 01:43:35,175 --> 01:43:38,312 PROGRAM AS WELL. 3022 01:43:38,378 --> 01:43:41,615 SHE PLOTTED THE NUMBERS HERE AND 3023 01:43:41,682 --> 01:43:44,217 SO NO SURPRISE, OUR CALIFORNIA 3024 01:43:44,284 --> 01:43:45,118 AND MASSACHUSETTS ARE OUR 3025 01:43:45,185 --> 01:43:46,420 HIGHEST STATES IN TERMS OF 3026 01:43:46,486 --> 01:43:47,287 DIVERSITY SUPPLEMENTS. 3027 01:43:47,354 --> 01:43:49,156 AND IT REALLY DOES SHOW THAT WE 3028 01:43:49,222 --> 01:43:50,457 PROBABLY HAVE TO DO SOME MORE 3029 01:43:50,524 --> 01:43:51,458 OUTREACH IN THE MIDDLE PART OF 3030 01:43:51,525 --> 01:43:52,926 THE COUNTRY AS WELL. 3031 01:43:52,993 --> 01:43:54,127 BUT THESE NUMBERS ARE REALLY 3032 01:43:54,194 --> 01:43:55,095 IMPORTANT AS WE REALLY THINK 3033 01:43:55,162 --> 01:43:56,296 ABOUT WHERE SHOULD WE PUT OUR 3034 01:43:56,363 --> 01:43:57,931 EFFORTS IN TERMS OF HOW THE 3035 01:43:57,998 --> 01:44:03,604 REACH MOVING FORWARD. 3036 01:44:03,670 --> 01:44:05,472 THEN LASTLY FOR THE DIVERSITY 3037 01:44:05,539 --> 01:44:07,307 SUPPLEMENT PROGRAM, NIH HOLDS A 3038 01:44:07,374 --> 01:44:08,508 PROFESSIONAL DEVELOPMENT IN 3039 01:44:08,575 --> 01:44:12,012 NETWORKING WORKSHOP, AND IN 3040 01:44:12,079 --> 01:44:13,447 2023, NIMH HAD THE BIGGEST 3041 01:44:13,513 --> 01:44:14,848 SHOWING IN TERMS OF OUR 3042 01:44:14,915 --> 01:44:16,583 DIVERSITY SUPPLEMENT AWARDEES. 3043 01:44:16,650 --> 01:44:17,818 FOR THIS WORKSHOP. 3044 01:44:17,884 --> 01:44:19,653 IT IS A TWO-DAY WORKSHOP. 3045 01:44:19,720 --> 01:44:22,823 IT'S VIRTUAL TO ALLOW PEOPLE 3046 01:44:22,889 --> 01:44:24,157 FROM ALL PLACES IN THE UNITED 3047 01:44:24,224 --> 01:44:26,426 STATES TO BE ABLE TO 3048 01:44:26,493 --> 01:44:27,094 PARTICIPATE. 3049 01:44:27,160 --> 01:44:28,829 WHAT'S WONDERFUL IS THEY GET TO 3050 01:44:28,895 --> 01:44:30,797 INTERACT WITH THE PROGRAM 3051 01:44:30,864 --> 01:44:32,532 OFFICERS, THEY GET TO INTERACT 3052 01:44:32,599 --> 01:44:34,067 WITH THE I.C. DIRECTOR, AND 3053 01:44:34,134 --> 01:44:37,337 REALLY AN OPPORTUNITY TO KIND OF 3054 01:44:37,404 --> 01:44:39,439 DEMYSTIFY NIH, AND NETWORK 3055 01:44:39,506 --> 01:44:41,174 OPPORTUNITY AS WELL. 3056 01:44:41,241 --> 01:44:42,709 WE PROMOTE THIS WORKSHOP QUITE A 3057 01:44:42,776 --> 01:44:45,445 BIT AND I'M REALLY PROUD TO SAY 3058 01:44:45,512 --> 01:44:47,748 NIMH HAD THE BIGGEST SHOWING 3059 01:44:47,814 --> 01:44:49,049 LAST YEAR. 3060 01:44:49,116 --> 01:44:51,351 THIS UPCOMING ONE IS IN 3061 01:44:51,418 --> 01:44:52,452 SEPTEMBER, THIS UPCOMING 3062 01:44:52,519 --> 01:44:53,720 SEPTEMBER WE'RE REALLY HOPING TO 3063 01:44:53,787 --> 01:44:59,092 HAVE SUCH A BIG SHOWING AS WELL. 3064 01:44:59,159 --> 01:45:00,927 SO NOW I'D LIKE TO MOVE TO OUR 3065 01:45:00,994 --> 01:45:01,928 WOMEN'S MENTAL HEALTH RESEARCH 3066 01:45:01,995 --> 01:45:03,230 PROGRAM UNDER TAMARA LEWIS 3067 01:45:03,296 --> 01:45:04,231 JOHNSON AND HER LEADERSHIP. 3068 01:45:04,297 --> 01:45:08,535 THIS HAS BEEN A BUSY YEAR, AND 3069 01:45:08,602 --> 01:45:10,003 SO THE WHITE HOUSE HAD A WHITE 3070 01:45:10,070 --> 01:45:11,438 HOUSE INITIATIVE ON WOMEN'S 3071 01:45:11,505 --> 01:45:13,607 HEALTH RESEARCH, AND SO WITH THE 3072 01:45:13,674 --> 01:45:15,142 OFFICE OF RESEARCH ON WOMEN'S 3073 01:45:15,208 --> 01:45:16,777 HEALTH HERE AT NIH AND SEVERAL 3074 01:45:16,843 --> 01:45:18,879 OTHER INSTITUTES AND CENTERS, 3075 01:45:18,945 --> 01:45:22,249 SUCH AS NIMH, WE PRODUCED A 3076 01:45:22,315 --> 01:45:24,651 NOTICE OF SPECIAL INTEREST IN 3077 01:45:24,718 --> 01:45:25,419 HIGHLIGHTING INTEREST IN 3078 01:45:25,485 --> 01:45:26,820 RECEIVING RESEARCH APPLICATIONS 3079 01:45:26,887 --> 01:45:28,689 FOCUSING ON DISEASE AND HEALTH 3080 01:45:28,755 --> 01:45:30,424 CONDITIONS THAT PREDOMINANTLY 3081 01:45:30,490 --> 01:45:31,091 AFFECT WOMEN. 3082 01:45:31,158 --> 01:45:34,161 SO THAT NOSI IS CURRENTLY LIVE. 3083 01:45:34,227 --> 01:45:35,562 ADDITIONALLY, BASED ON THE WHITE 3084 01:45:35,629 --> 01:45:38,632 HOUSE INITIATIVE, TAMARA IS 3085 01:45:38,699 --> 01:45:40,734 HOSTING A WOMEN'S ROUNDTABLE IN 3086 01:45:40,801 --> 01:45:42,803 THE FALL OF 2024. 3087 01:45:42,869 --> 01:45:45,505 IT WILL BE AN ALL DAY OR HALF A 3088 01:45:45,572 --> 01:45:47,507 DAY EVENT AND IT'S REALLY 3089 01:45:47,574 --> 01:45:48,341 SPOTLIGHTING THE PRIORITY AREAS 3090 01:45:48,408 --> 01:45:49,810 OF RESEARCH RELATED TO WOMEN'S 3091 01:45:49,876 --> 01:45:52,212 HEALTH DURING PREGNANCY AND THE 3092 01:45:52,279 --> 01:45:53,847 POSTPARTUM PERIOD AS WELL, AND 3093 01:45:53,914 --> 01:45:56,483 WE WILL ALSO HAVE WOMEN WITH 3094 01:45:56,550 --> 01:45:59,286 LIVED EXPERIENCE AS PART OF THAT 3095 01:45:59,352 --> 01:46:03,190 ROUNDTABLE DISCUSSION. 3096 01:46:03,256 --> 01:46:04,624 I'M ALSO VERY PLEASED ABOUT THIS 3097 01:46:04,691 --> 01:46:05,692 PROGRAM UNDER TAMARA'S 3098 01:46:05,759 --> 01:46:06,460 LEADERSHIP AS WELL. 3099 01:46:06,526 --> 01:46:08,428 SO OUR CAREER CONTINUITY 3100 01:46:08,495 --> 01:46:11,264 INITIATIVE, IT'S AN NIH-WIDE 3101 01:46:11,331 --> 01:46:13,467 INITIATIVE, AND IT'S REALLY AN 3102 01:46:13,533 --> 01:46:16,770 OPPORTUNITY FOR PEOPLE WHO HAVE 3103 01:46:16,837 --> 01:46:18,839 EXPERIENCED A CRITICAL LIFE 3104 01:46:18,905 --> 01:46:19,806 EVENT: PREGNANCY, TAKING CARE 3105 01:46:19,873 --> 01:46:25,045 OF A SICK SPOUSE, AILING PARENT, 3106 01:46:25,112 --> 01:46:26,146 YOU YOURSELF ARE ILL, BOTH AT 3107 01:46:26,213 --> 01:46:28,882 THE K AWARD STAGE OR YOUR FIRST 3108 01:46:28,949 --> 01:46:30,550 INDEPENDENT R GRANT, LIKE YOUR 3109 01:46:30,617 --> 01:46:32,419 RESEARCH PROJECT GRANT, YOUR 3110 01:46:32,486 --> 01:46:33,086 FIRST INDEPENDENT GRANT. 3111 01:46:33,153 --> 01:46:35,155 YOU ARE ELIGIBLE TO APPLY FOR A 3112 01:46:35,222 --> 01:46:36,389 CAREER CONTINUITY INITIATIVE, 3113 01:46:36,456 --> 01:46:38,892 WHICH ALLOWS YOU TO GET 3114 01:46:38,959 --> 01:46:41,661 ADDITIONAL FUNDS TO HELP 3115 01:46:41,728 --> 01:46:42,763 SUPPLEMENT YOUR KIND OF ABSENCE 3116 01:46:42,829 --> 01:46:44,164 FROM THE LAB TO BE ABLE TO KEEP 3117 01:46:44,231 --> 01:46:50,203 YOU IN RESEARCH. 3118 01:46:50,270 --> 01:46:52,139 AGAIN, I THINK NIMH FALLS AS 3119 01:46:52,205 --> 01:46:52,839 NUMBER EIGHT IN TERMS OF NUMBER 3120 01:46:52,906 --> 01:46:55,976 OF GRANTS, BUT WE RANK NUMBER 3121 01:46:56,042 --> 01:46:57,410 THREE IN HOW MANY CAREER 3122 01:46:57,477 --> 01:46:59,146 CONTINUITY APPLICATIONS WE FUND. 3123 01:46:59,212 --> 01:47:01,448 SO IT'S A PROGRAM WE TAKE VERY 3124 01:47:01,515 --> 01:47:01,715 SERIOUSLY. 3125 01:47:01,782 --> 01:47:03,316 IT ALSO PART OF OUR OUTREACH 3126 01:47:03,383 --> 01:47:09,089 EFFORT IN TERMS OF LEEING PEOPLE 3127 01:47:09,156 --> 01:47:10,524 KNOW THIS IS AN OPPORTUNITY TO 3128 01:47:10,590 --> 01:47:11,958 KEEP PEOPLE IN SCIENCE IF THEY 3129 01:47:12,025 --> 01:47:13,693 HAVE TO STEP AWAY FOR AN 3130 01:47:13,760 --> 01:47:15,529 EXTENDED AMOUNT OF TIME SO WE'RE 3131 01:47:15,595 --> 01:47:16,963 VERY PLEASED ABOUT THIS PROGRAM. 3132 01:47:17,030 --> 01:47:18,932 IN TERMS OF OUR RURAL MENTAL 3133 01:47:18,999 --> 01:47:20,834 HEALTH RESEARCH, WE HAD A 3134 01:47:20,901 --> 01:47:22,803 WEBINAR LAST YEAR COMING 3135 01:47:22,869 --> 01:47:24,004 FACE-TO-FACE WITH SUICIDE IN 3136 01:47:24,070 --> 01:47:27,941 AMERICAN FARMING, AND I WAS SO 3137 01:47:28,008 --> 01:47:28,809 SURPRISED, PLEASANTLY SURPRISED, 3138 01:47:28,875 --> 01:47:31,011 WE HAD OVER 2,000 PEOPLE 3139 01:47:31,077 --> 01:47:31,778 REGISTER FOR THAT. 3140 01:47:31,845 --> 01:47:34,381 AND IT WAS OUR REGISTRATION 3141 01:47:34,447 --> 01:47:35,482 REPRESENTED NOT JUST ACADEMICS, 3142 01:47:35,549 --> 01:47:39,119 BUT PEOPLE IN THE COMMUNITY. 3143 01:47:39,186 --> 01:47:39,452 WHO 3144 01:47:39,519 --> 01:47:43,990 ARE THINKING ABOUT OUR FARMERS 3145 01:47:44,057 --> 01:47:45,258 AND THE LACK OF SERVICES AND 3146 01:47:45,325 --> 01:47:45,992 RESOURCES FOR THEM. 3147 01:47:46,059 --> 01:47:48,428 AND SO IT WAS AN EXTREMELY WELL 3148 01:47:48,495 --> 01:47:53,366 ATTENDED WEBINAR SERIES. 3149 01:47:53,433 --> 01:47:55,001 NIMH'S RURAL PORTFOLIO IS 3150 01:47:55,068 --> 01:47:55,969 STEADILY INCREASING, AS YOU CAN 3151 01:47:56,036 --> 01:47:57,838 SEE FROM 2018 TO 2023, WE'VE 3152 01:47:57,904 --> 01:48:00,240 ALMOST DOUBLED OUR PORTFOLIO IN 3153 01:48:00,307 --> 01:48:03,076 RURAL MENTAL HEALTH. 3154 01:48:03,143 --> 01:48:04,711 THEN I LIKE TO SAY THIS CAME OUT 3155 01:48:04,778 --> 01:48:06,446 SO THIS LITERALLY JUST GOT PUT 3156 01:48:06,513 --> 01:48:10,784 IN THE SLIDE NOT THAT LONG AGO, 3157 01:48:10,851 --> 01:48:13,520 NIMH CONTRACTED -- SUPPLIED A 3158 01:48:13,587 --> 01:48:14,588 CONTRACT FOR A RURAL MENTAL 3159 01:48:14,654 --> 01:48:18,191 HEALTH IN THE UNITED STATES 3160 01:48:18,258 --> 01:48:18,391 BOOK. 3161 01:48:18,458 --> 01:48:20,760 IT IS FREE TO THE PUBLIC, AND SO 3162 01:48:20,827 --> 01:48:22,762 THIS WAS FUNDED BY US AS A 3163 01:48:22,829 --> 01:48:24,698 CONTRACT AND IT'S DOWNLOADABLE 3164 01:48:24,764 --> 01:48:27,000 AND FREE AND SO OUR HOPE IS TO 3165 01:48:27,067 --> 01:48:30,637 DISSEMINATE THIS WIDELY, BUT IT 3166 01:48:30,704 --> 01:48:32,005 REALLY TALKS ABOUT THE STATE OF 3167 01:48:32,072 --> 01:48:32,839 RURAL MENTAL HEALTH IN THIS 3168 01:48:32,906 --> 01:48:37,844 COUNTRY FROM 2006 TO 2022. 3169 01:48:37,911 --> 01:48:40,146 THEN ADDITIONALLY IN TERMS OF 3170 01:48:40,213 --> 01:48:41,882 AMERICAN INDIAN AND ALASKA 3171 01:48:41,948 --> 01:48:43,817 NATIVE SCIENCE, NIMH IS PART OF 3172 01:48:43,884 --> 01:48:47,153 THREE MAJOR PROGRAMS AT NIH. 3173 01:48:47,220 --> 01:48:48,688 THE IRINAH PROGRAM REALLY 3174 01:48:48,755 --> 01:48:50,457 LOOKING AT INTERVENTION RESEARCH 3175 01:48:50,523 --> 01:48:52,959 FOR OUR NATIVE AMERICAN 3176 01:48:53,026 --> 01:48:54,461 POPULATION, NARCH, OUR NATIVE 3177 01:48:54,527 --> 01:48:55,462 AMERICAN RESEARCH CENTERS FOR 3178 01:48:55,528 --> 01:48:57,898 HEALTH, WE DID FUND ONE IN 2021. 3179 01:48:57,964 --> 01:49:01,301 AND THIS IS KIND OF A 3180 01:49:01,368 --> 01:49:03,069 THREE-PRONGED FUNDING 3181 01:49:03,136 --> 01:49:04,037 OPPORTUNITY WHERE IT'S REALLY 3182 01:49:04,104 --> 01:49:07,340 LOOKING AT RESEARCH, CAPACITY 3183 01:49:07,407 --> 01:49:08,275 BUILDING IN TERMS OF THE 3184 01:49:08,341 --> 01:49:09,809 INSTITUTION AND ALSO TRAINING IN 3185 01:49:09,876 --> 01:49:10,944 TERMS OF THE NEXT GENERATION AS 3186 01:49:11,011 --> 01:49:13,647 WELL. 3187 01:49:13,713 --> 01:49:14,514 AND THEN LASTLY, PART OF THE 3188 01:49:14,581 --> 01:49:15,949 HEAL INITIATIVE, THE NATIVE 3189 01:49:16,016 --> 01:49:17,484 COLLECTIVE RESEARCH EFFORT TO 3190 01:49:17,550 --> 01:49:22,188 ENHANCE WELLNESS PROGRAM, IS 3191 01:49:22,255 --> 01:49:23,590 REALLY LED IN TERMS OF OUR 3192 01:49:23,657 --> 01:49:25,025 TRIBAL ORGANIZATIONS AND WHAT 3193 01:49:25,091 --> 01:49:27,761 ARE THEIR PRIORITY AREAS IN 3194 01:49:27,827 --> 01:49:29,663 THINKING ABOUT OVERDOSE 3195 01:49:29,729 --> 01:49:30,730 SUBSTANCE USE MENTAL HEALTH AND 3196 01:49:30,797 --> 01:49:32,899 PAIN, AND SO NIMH IS SIGNED ON 3197 01:49:32,966 --> 01:49:39,172 TO ALL THREE OF THESE. 3198 01:49:39,239 --> 01:49:40,273 WE HEARD ABOUT COMPASS I THINK 3199 01:49:40,340 --> 01:49:41,241 AT THE LAST COUNCIL AND WE'VE 3200 01:49:41,308 --> 01:49:42,442 TALKED A LITTLE BIT ABOUT 3201 01:49:42,509 --> 01:49:43,009 COMPASS TODAY. 3202 01:49:43,076 --> 01:49:48,248 SO I WON'T GO TOO MUCH INTO IT. 3203 01:49:48,315 --> 01:49:52,519 BUT BUT AS JOSH SAID EARLIER 3204 01:49:52,585 --> 01:49:53,787 THIS MORNING OR THIS AFTERNOON, 3205 01:49:53,853 --> 01:49:55,789 IT IS REALLY LOOKING AT FUNDED 3206 01:49:55,855 --> 01:49:56,456 COMMUNITY-BASED ORGANIZATIONS TO 3207 01:49:56,523 --> 01:49:59,626 REALLY THINKING ABOUT 3208 01:49:59,693 --> 01:50:01,261 INTERVENTIONS AND SO WE ARE VERY 3209 01:50:01,328 --> 01:50:05,398 PLEASED TO SAY THAT DIRECTION 3210 01:50:05,465 --> 01:50:07,701 WILL UNIVERSITY IS NOW OUR 3211 01:50:07,767 --> 01:50:11,004 COORDINATING CENTER FOR COMPASS, 3212 01:50:11,071 --> 01:50:12,205 DREXEL, SO 25 OF THE GRANTS FOR 3213 01:50:12,272 --> 01:50:13,974 THE COMMUNITY-BASED 3214 01:50:14,040 --> 01:50:16,042 ORGANIZATIONS WHICH WE CALL 3215 01:50:16,109 --> 01:50:18,345 CHESIs HAVE BEEN FUNDED. 3216 01:50:18,411 --> 01:50:21,748 JENNIFER VILLATTE IN OUR OFFICE 3217 01:50:21,815 --> 01:50:23,083 OVERSEES THOSE SEVEN OF 25 SO 3218 01:50:23,149 --> 01:50:24,384 NIMH HAS A CRITICAL ROLE IN THIS 3219 01:50:24,451 --> 01:50:26,252 PROGRAM. 3220 01:50:26,319 --> 01:50:27,587 AND THEN RIGHT NOW, APPLICATIONS 3221 01:50:27,654 --> 01:50:28,788 ARE BEING REVIEWED FOR THE 3222 01:50:28,855 --> 01:50:30,423 HEALTH EQUITY RESEARCH HUBS, 3223 01:50:30,490 --> 01:50:31,858 WHICH REALLY WILL PROVIDE THAT 3224 01:50:31,925 --> 01:50:33,293 TECHNICAL ASSISTANCE BOTH THE A 3225 01:50:33,360 --> 01:50:36,129 PHASE ONE AND PHASE -- PHASE TWO 3226 01:50:36,196 --> 01:50:37,964 AND PHASE THREE, WHICH IS THE 3227 01:50:38,031 --> 01:50:41,368 INTERVENTION PHASE I AND THE 3228 01:50:41,434 --> 01:50:42,802 DISSEMINATION FADES, SO WE'RE 3229 01:50:42,869 --> 01:50:43,903 HOPING THOSE WILL BE ANNOUNCED 3230 01:50:43,970 --> 01:50:44,471 SOMETIME IN JULY. 3231 01:50:44,537 --> 01:50:46,106 SO COMPASS IS UP AND RUNNING, 3232 01:50:46,172 --> 01:50:48,274 AND LIKE I SAID, JENNIFER IS 3233 01:50:48,341 --> 01:50:49,743 OVERSEEING SEVEN OF THESE AS 3234 01:50:49,809 --> 01:50:54,514 WELL. 3235 01:50:54,581 --> 01:50:57,150 I'M ALMOST RIGHT ON TIME, TRACY. 3236 01:50:57,217 --> 01:50:58,585 SO I'D LIKE TO END -- SO THIS IS 3237 01:50:58,651 --> 01:51:00,887 A LITTLE SNAPSHOT OF WHAT OUR 3238 01:51:00,954 --> 01:51:02,422 OFFICE AND THE DISPARITIES TEAM 3239 01:51:02,489 --> 01:51:04,391 HAS BEEN WORKING ON FOR THE PAST 3240 01:51:04,457 --> 01:51:05,492 COUPLE YEARS. 3241 01:51:05,558 --> 01:51:07,627 AND I'D LIKE TO END TO REALLY 3242 01:51:07,694 --> 01:51:08,695 THINKING ABOUT -- AND THIS IS 3243 01:51:08,762 --> 01:51:13,066 REALLY WHERE I'D LOVE TO ENGAGE 3244 01:51:13,133 --> 01:51:14,167 COUNCIL AND YOUR THOUGHTS AS 3245 01:51:14,234 --> 01:51:16,036 WELL, REALLY THINKING ABOUT 3246 01:51:16,102 --> 01:51:16,703 CENTERING EQUITY IN EVERYTHING 3247 01:51:16,770 --> 01:51:20,173 THAT WE DO AT NIMH. 3248 01:51:20,240 --> 01:51:21,841 SO WHAT DO I MEAN BY CENTERING 3249 01:51:21,908 --> 01:51:22,175 EQUITY? 3250 01:51:22,242 --> 01:51:23,476 IT'S REALLY THINKING ABOUT HOW 3251 01:51:23,543 --> 01:51:25,879 WE DO RESEARCH, WHO IS INVOLVED 3252 01:51:25,945 --> 01:51:28,214 IN OUR RESEARCH, OUR 3253 01:51:28,281 --> 01:51:30,417 PARTICIPANTS, BUT HOW WERE THEY 3254 01:51:30,483 --> 01:51:30,750 INVOLVED? 3255 01:51:30,817 --> 01:51:33,119 ARE THEY INVOLVED JUST AT THE 3256 01:51:33,186 --> 01:51:34,354 BEGINNING, IN AN ADVISORY BOARD 3257 01:51:34,421 --> 01:51:35,989 CAPACITY, OR ARE THEY TRULY AT 3258 01:51:36,056 --> 01:51:37,190 THE TABLE AND REALLY THINKING 3259 01:51:37,257 --> 01:51:38,625 ABOUT OUR QUESTIONS AND WHAT WE 3260 01:51:38,691 --> 01:51:41,361 SHOULD BE ASKING HOW DATA IS 3261 01:51:41,428 --> 01:51:43,129 COLLECTED, HOW ARE WE ANALYZING 3262 01:51:43,196 --> 01:51:44,798 THAT DATA AND HOW DO WE 3263 01:51:44,864 --> 01:51:45,765 DISSEMINATE THAT INFORMATION 3264 01:51:45,832 --> 01:51:47,834 BACK INTO THE COMMUNITY? 3265 01:51:47,901 --> 01:51:49,803 RESEARCH CAPACITY BUILDING AND 3266 01:51:49,869 --> 01:51:51,137 WORKFORCE DEVELOPMENT I THINK IS 3267 01:51:51,204 --> 01:51:54,407 AT THE CORE OF WHAT WE SHOULD BE 3268 01:51:54,474 --> 01:51:59,012 THINKING ABOUT, AND HOW DO WE 3269 01:51:59,079 --> 01:52:00,980 BUILD NOT JUST STUDENTS AND 3270 01:52:01,047 --> 01:52:02,215 FACULTY MEMBERS BUT INSTITUTIONS 3271 01:52:02,282 --> 01:52:03,616 AND COMMUNITY PART NES TO 3272 01:52:03,683 --> 01:52:05,151 SUPPORT INCLUSION AND EQUITY IN 3273 01:52:05,218 --> 01:52:06,519 ALL THAT WE DO, SO THAT REALLY 3274 01:52:06,586 --> 01:52:07,954 IS A TWO-PRONG THINKING ABOUT 3275 01:52:08,021 --> 01:52:09,422 INDIVIDUAL TRAINING BUT ALSO 3276 01:52:09,489 --> 01:52:10,290 THINKING ABOUT INSTITUTIONAL 3277 01:52:10,356 --> 01:52:13,293 DEVELOPMENT AS WELL. 3278 01:52:13,359 --> 01:52:14,394 THEN ALSO IN THINKING ABOUT 3279 01:52:14,461 --> 01:52:15,361 TAKING AN INTERSECTIONAL LENS IN 3280 01:52:15,428 --> 01:52:17,163 EVERYTHING THAT WE DO, AND 3281 01:52:17,230 --> 01:52:20,133 LOOKING AT WHAT ARE SOME OF OUR 3282 01:52:20,200 --> 01:52:20,900 EXPLORING MORE OF 3283 01:52:20,967 --> 01:52:22,969 INTERSECTIONALITY OF 3284 01:52:23,036 --> 01:52:24,604 UNDERSTUDIED SOCIAL IDENTITIES, 3285 01:52:24,671 --> 01:52:25,305 BUT THEN ALSO REALLY 3286 01:52:25,371 --> 01:52:27,941 INVESTIGATING THE MECHANISMS OF 3287 01:52:28,007 --> 01:52:30,243 HOW INTERSECTING SYSTEMS OF 3288 01:52:30,310 --> 01:52:31,611 OPPRESSION INTERACT WITH MENTAL 3289 01:52:31,678 --> 01:52:33,012 HEALTH OUTCOMES, SO IT'S REALLY 3290 01:52:33,079 --> 01:52:36,616 LOOKING AT OUR INDIVIDUAL SOCIAL 3291 01:52:36,683 --> 01:52:38,118 IDENTITIES BUT ALSO OUR SYSTEMS 3292 01:52:38,184 --> 01:52:39,919 AND THAT INTERSECTION OF BOTH. 3293 01:52:39,986 --> 01:52:41,754 SO THINKING ABOUT THESE THREE IN 3294 01:52:41,821 --> 01:52:43,857 TERMS OF COMMUNITY ENGAGEMENT, 3295 01:52:43,923 --> 01:52:47,494 CAPACITY BUILDING, AND 3296 01:52:47,560 --> 01:52:48,094 INTERSECTIONALITY, IN ALL THE 3297 01:52:48,161 --> 01:52:50,230 WORK THAT WE DO AT NIMH IS 3298 01:52:50,296 --> 01:52:50,997 REALLY AN APPROACH WE'RE 3299 01:52:51,064 --> 01:52:52,565 THINKING ABOUT IN TERMS OF 3300 01:52:52,632 --> 01:52:53,233 FURTHERING MENTAL HEALTH EQUITY 3301 01:52:53,299 --> 01:52:53,566 AS WELL. 3302 01:52:53,633 --> 01:52:56,369 SO I WANT TO END BY SAYING THANK 3303 01:52:56,436 --> 01:52:56,603 YOU. 3304 01:52:56,669 --> 01:52:57,737 FOR THOSE OF YOU WHO WANT TO BE 3305 01:52:57,804 --> 01:53:00,273 ON THE WAIT LIST FOR THE 3306 01:53:00,340 --> 01:53:01,474 DISCRIMINATION WORKSHOP, YOU CAN 3307 01:53:01,541 --> 01:53:02,742 EMAIL ME DIRECTLY AND I WILL PUT 3308 01:53:02,809 --> 01:53:04,744 YOU ON THE WAIT LIST. 3309 01:53:04,811 --> 01:53:06,112 AND THEN I WOULD LOVE TO OPEN IT 3310 01:53:06,179 --> 01:53:10,416 UP FOR QUESTIONS FROM COUNCIL 3311 01:53:10,483 --> 01:53:11,818 BUT I'M GOING TO LEAVE YOU WITH 3312 01:53:11,885 --> 01:53:14,454 THTHREE QUESTIONS AS WELL. 3313 01:53:14,521 --> 01:53:16,456 HOW DOES NIMH EFFECTIVELY SHIFT 3314 01:53:16,523 --> 01:53:17,657 TO CENTER EQUITY IN ALL STAGES 3315 01:53:17,724 --> 01:53:18,091 OF SCIENCE? 3316 01:53:18,158 --> 01:53:20,059 WHAT ARE THE NIMH PRIORITIES ON 3317 01:53:20,126 --> 01:53:21,227 MENTAL HEALTH DISPARITIES THAT 3318 01:53:21,294 --> 01:53:22,362 REALLY RISE TO THE TOP FOR YOU? 3319 01:53:22,428 --> 01:53:23,696 AND WHAT ARE YOUR CURRENT 3320 01:53:23,763 --> 01:53:24,898 CHALLENGES WITHIN YOUR OWN 3321 01:53:24,964 --> 01:53:25,999 INSTITUTIONS IN SUPPORTING 3322 01:53:26,065 --> 01:53:27,000 HEALTH DISPARITIES RESEARCH AND 3323 01:53:27,066 --> 01:53:28,935 HOW DO WE EFFECTIVELY SHIFT TO 3324 01:53:29,002 --> 01:53:31,237 INCLUDE A MORE DIVERSE 3325 01:53:31,304 --> 01:53:32,338 PERSPECTIVE IN OUR WORK THAT WE 3326 01:53:32,405 --> 01:53:32,572 DO? 3327 01:53:32,639 --> 01:53:40,680 THANK YOU. 3328 01:53:40,747 --> 01:53:43,183 >> THANK YOU, CHRISTINA. 3329 01:53:43,249 --> 01:53:44,050 QUESTIONS OR COMMENTS FROM 3330 01:53:44,117 --> 01:53:44,817 MEMBERS OF COUNCIL? 3331 01:53:44,884 --> 01:53:46,219 AND I'VE GOT ALREADY A COUPLE 3332 01:53:46,286 --> 01:53:48,888 RAISED HANDS SO WE'RE GOING TO 3333 01:53:48,955 --> 01:53:52,158 START WITH JYOTI. 3334 01:53:52,225 --> 01:53:55,061 >> THANK YOU, THAT WAS A LOVELY 3335 01:53:55,128 --> 01:53:55,528 PRESENTATION. 3336 01:53:55,595 --> 01:53:56,996 YOU ACTUALLY -- THE LAST TWO 3337 01:53:57,063 --> 01:53:59,165 QUESTIONS IN THIS CURRENT SLIDE 3338 01:53:59,232 --> 01:54:01,401 IS WHAT I'D LIKE TO HEAR YOUR 3339 01:54:01,467 --> 01:54:02,168 THOUGHTS ON. 3340 01:54:02,235 --> 01:54:04,337 A BIG ISSUE THAT WE SEE IN TYPE 3341 01:54:04,404 --> 01:54:08,241 OF THE WORK THAT I DO AND 3342 01:54:08,308 --> 01:54:09,242 BROADLY IN MENTAL HEALTH 3343 01:54:09,309 --> 01:54:11,411 SERVICES RESEARCH IS THAT THE 3344 01:54:11,477 --> 01:54:13,613 DATA INFRASTRUCTURE IN AND OF 3345 01:54:13,680 --> 01:54:16,382 ITSELF INTRODUCES BIASES, SO 3346 01:54:16,449 --> 01:54:17,617 TYPE OF DATA THAT WE ARE 3347 01:54:17,684 --> 01:54:19,052 COLLECTING, PEOPLE WHO ARE 3348 01:54:19,118 --> 01:54:21,454 SEEKING CARE, AND SO AS A 3349 01:54:21,521 --> 01:54:25,158 RESULT, ANY FINDINGS THAT WE DO 3350 01:54:25,225 --> 01:54:27,927 INTENTIONALLY OR UNINTENTIONALLY 3351 01:54:27,994 --> 01:54:29,229 INJECT THAT BIAS. 3352 01:54:29,295 --> 01:54:30,863 SO I'M CURIOUS TO SEE WHAT ARE 3353 01:54:30,930 --> 01:54:32,899 YOUR THOUGHTS, WHAT ARE SOME 3354 01:54:32,966 --> 01:54:33,800 POTENTIAL INVESTMENTS THAT WHEN 3355 01:54:33,866 --> 01:54:36,970 IT COMES TO SORT OF FUNDAMENTAL 3356 01:54:37,036 --> 01:54:38,004 RESEARCH INFRASTRUCTURE, THAT 3357 01:54:38,071 --> 01:54:41,874 YOUR OFFICE OR OTHER NIH ICs 3358 01:54:41,941 --> 01:54:42,809 ARE PLANNING TO SUPPORT? 3359 01:54:42,875 --> 01:54:44,711 >> YEAH, AND I THINK ESPECIALLY 3360 01:54:44,777 --> 01:54:48,081 WITH THE MOVEMENT NOW OF 3361 01:54:48,147 --> 01:54:50,717 ARTIFICIAL INTELLIGENCE AND BIG 3362 01:54:50,783 --> 01:54:52,785 DATA SCIENCE, WHAT I'VE BEEN 3363 01:54:52,852 --> 01:54:54,087 PLEASED TO SEE IS THE 3364 01:54:54,153 --> 01:54:55,421 DISCUSSIONS AROUND THE TABLE IN 3365 01:54:55,488 --> 01:54:57,924 TERMS OF THAT BIAS, AND HOW DO 3366 01:54:57,991 --> 01:55:00,627 WE MITIGATE THAT BIAS AS WELL, 3367 01:55:00,693 --> 01:55:02,161 AND SO THOSE ARE DISCUSSIONS 3368 01:55:02,228 --> 01:55:05,665 THAT WE'RE HAVING, BUT I FIND 3369 01:55:05,732 --> 01:55:08,968 THAT HAVING A DIVERSE 3370 01:55:09,035 --> 01:55:11,471 PERSPECTIVE AT THE TABLE BEING 3371 01:55:11,537 --> 01:55:13,406 OUR CLINICIANS, PROVIDERS, 3372 01:55:13,473 --> 01:55:14,841 TRAINEES, THOSE WHO ARE SEEING 3373 01:55:14,907 --> 01:55:17,443 PATIENTS ON A REGULAR BASIS BE 3374 01:55:17,510 --> 01:55:18,111 PART OF THE CONVERSATION IN 3375 01:55:18,177 --> 01:55:19,979 TERMS OF WHAT ARE THE DATA 3376 01:55:20,046 --> 01:55:21,180 VARIABLES THAT WE'RE COLLECTING, 3377 01:55:21,247 --> 01:55:25,752 HOW ARE WE COLLECTING THEM, I 3378 01:55:25,818 --> 01:55:26,853 THINK IS IMPORTANT, AND ALSO 3379 01:55:26,919 --> 01:55:27,954 DEPENDING ON WHAT CLINICAL 3380 01:55:28,021 --> 01:55:29,322 CENTER YOU'RE AT OR WHAT 3381 01:55:29,389 --> 01:55:29,922 HOSPITAL YOU'RE AT WILL 3382 01:55:29,989 --> 01:55:32,425 DETERMINE WHAT TYPE OF DATA IS 3383 01:55:32,492 --> 01:55:36,796 COLLECTED, AND WE KNOW IT'S JUST 3384 01:55:36,863 --> 01:55:39,098 REALLY LOADED WITH BIAS, SO FOR 3385 01:55:39,165 --> 01:55:40,733 ME, IT GOES BACK TO THE HEART OF 3386 01:55:40,800 --> 01:55:41,701 GETTING THE RIGHT PEOPLE AT THE 3387 01:55:41,768 --> 01:55:43,803 TABLE TO HELP THINK THROUGH SOME 3388 01:55:43,870 --> 01:55:46,506 OF THESE REALLY COMPLICATED 3389 01:55:46,572 --> 01:55:47,607 QUESTIONS. 3390 01:55:47,674 --> 01:55:49,575 I HAVE TO SAY WE'RE ALL VERY 3391 01:55:49,642 --> 01:55:51,344 SMART IN THIS ROOM BUT WE MISS A 3392 01:55:51,411 --> 01:55:53,313 LOT WHEN WE DON'T HAVE THAT 3393 01:55:53,379 --> 01:55:55,581 DIVERSE PERSPECTIVE, SO THINKING 3394 01:55:55,648 --> 01:55:56,449 ABOUT DIFFERENT TYPES OF 3395 01:55:56,516 --> 01:55:58,751 MECHANISMS AND FUNDING 3396 01:55:58,818 --> 01:55:59,852 MECHANISMS, MY PRIORITY IS TO 3397 01:55:59,919 --> 01:56:00,953 MAKE SURE THAT I'M HEARING FROM 3398 01:56:01,020 --> 01:56:03,890 THE EXTRAMURAL WORKFORCE AT ALL 3399 01:56:03,956 --> 01:56:05,425 LEVELS BEFORE WE START MAKING 3400 01:56:05,491 --> 01:56:07,126 THOSE DECISIONS. 3401 01:56:07,193 --> 01:56:08,628 SO THAT'S NOT REALLY AN ANSWER 3402 01:56:08,695 --> 01:56:10,296 TO YOUR QUESTION, BUT AN 3403 01:56:10,363 --> 01:56:15,335 APPROACH. 3404 01:56:15,401 --> 01:56:16,969 >> NEXT IS RINAD. 3405 01:56:17,036 --> 01:56:19,238 >> THANK YOU SO MUCH FOR THAT 3406 01:56:19,305 --> 01:56:19,839 WONDERFUL PRESENTATION, AND I 3407 01:56:19,906 --> 01:56:21,841 LOVE HOW YOU AMPLIFIED YOUR 3408 01:56:21,908 --> 01:56:23,676 INCREDIBLE TEAM AS A LEADER AND 3409 01:56:23,743 --> 01:56:25,345 INCLUDED PEOPLE OF LIVED 3410 01:56:25,411 --> 01:56:26,112 EXPERIENCE AND COMMUNITY 3411 01:56:26,179 --> 01:56:27,113 MEMBERS. 3412 01:56:27,180 --> 01:56:28,314 I HAVE TWO SUGGESTIONS AND ALSO 3413 01:56:28,381 --> 01:56:31,584 A QUESTION. 3414 01:56:31,651 --> 01:56:33,152 SO FIRST SUGGESTION IS I LOVE TO 3415 01:56:33,219 --> 01:56:34,520 SEE HOW MANY DIVERSITY 3416 01:56:34,587 --> 01:56:35,488 SUPPLEMENTS NIMH IS SUPPORTING. 3417 01:56:35,555 --> 01:56:37,023 I THINK A NEXT STEP COULD BE 3418 01:56:37,090 --> 01:56:38,458 REALLY DOING SOME AUDIT AND 3419 01:56:38,524 --> 01:56:39,959 FEEDBACK AND DOING DIRECT 3420 01:56:40,026 --> 01:56:41,828 OUTREACH TO INVESTIGATORS, 3421 01:56:41,894 --> 01:56:42,795 ESPECIALLY IN THOSE STATES WHERE 3422 01:56:42,862 --> 01:56:44,864 THERE AREN'T A LOT OF 3423 01:56:44,931 --> 01:56:46,632 SUPPLEMENTS TO ENCOURAGE THEM TO 3424 01:56:46,699 --> 01:56:52,839 GET INVOLVED IN THAT PROGRAM. 3425 01:56:52,905 --> 01:56:54,140 THE SECOND, AS YOU THINK ABOUT 3426 01:56:54,207 --> 01:56:55,041 CENTERING EQUITY FOR YOUR FIRST 3427 01:56:55,108 --> 01:56:56,309 QUESTION, I THINK IT HAS TO BE 3428 01:56:56,376 --> 01:56:57,377 BUILT INTO THE REVIEW CRITERIA 3429 01:56:57,443 --> 01:56:58,378 AND I THINK IT HAS TO BE BUILT 3430 01:56:58,444 --> 01:56:59,946 IN THE ONGOING KIND OF 3431 01:57:00,012 --> 01:57:02,548 REGULATORY MONITORING, SO THINK 3432 01:57:02,615 --> 01:57:04,517 ABOUT DSMV, INCLUDING COMPONENTS 3433 01:57:04,584 --> 01:57:05,385 THAT ADDRESS WHETHER OR NOT THE 3434 01:57:05,451 --> 01:57:07,887 WORK IS EQUITABLY REACHING 3435 01:57:07,954 --> 01:57:08,988 POPULATIONS. 3436 01:57:09,055 --> 01:57:10,857 MY QUESTION FOR YOU MAPS ON TO 3437 01:57:10,923 --> 01:57:13,793 YOUR QUESTION ABOUT CAPACITY 3438 01:57:13,860 --> 01:57:16,529 BUILDING. 3439 01:57:16,596 --> 01:57:17,563 THIS IS SOMETHING THAT COMES UP 3440 01:57:17,630 --> 01:57:19,699 A LOT FOR ME AS I SUPPORT EARLY 3441 01:57:19,766 --> 01:57:21,000 CAREER FOLKS IN MY LAB. 3442 01:57:21,067 --> 01:57:24,804 SO STRUCTURAL DETERMINANTS 3443 01:57:24,871 --> 01:57:27,440 REQUIRE THE -- THE RESULT IN 3444 01:57:27,507 --> 01:57:28,641 INEQUITIES REQUIRE STRUCTURAL 3445 01:57:28,708 --> 01:57:30,376 INTERVENTION, AND I'M CURIOUS 3446 01:57:30,443 --> 01:57:31,477 ABOUT YOUR THOUGHTS ON HOW WE 3447 01:57:31,544 --> 01:57:33,012 ACTUALLY TRAIN THE NEXT 3448 01:57:33,079 --> 01:57:34,213 GENERATION OF RESEARCHERS TO BE 3449 01:57:34,280 --> 01:57:35,748 DOING WORK ON STRUCTURAL 3450 01:57:35,815 --> 01:57:36,616 INTERVENTIONS BECAUSE THAT SCALE 3451 01:57:36,682 --> 01:57:38,351 OF WORK IS VERY DIFFICULT FOR AN 3452 01:57:38,418 --> 01:57:39,585 EARLY CAREER PERSON OR GRADUATE 3453 01:57:39,652 --> 01:57:42,288 STUDENT OR POSTDOC TO TAKE ON. 3454 01:57:42,355 --> 01:57:46,225 SO THINKING ABOUT PLACE-BASED 3455 01:57:46,292 --> 01:57:47,126 INTERVENTIONS, SCREENING, THE 3456 01:57:47,193 --> 01:57:48,961 NUMBER OF COMMUNITIES YOU NEED 3457 01:57:49,028 --> 01:57:51,164 TO BE WORKING WITH IS REALLY OUT 3458 01:57:51,230 --> 01:57:52,565 OF SCALE FOR WHAT OUR EARLY 3459 01:57:52,632 --> 01:57:54,200 CAREER FOLKS CAN DO SO CURIOUS 3460 01:57:54,267 --> 01:57:55,468 HOW YOU'RE THINKING ABOUT THAT. 3461 01:57:55,535 --> 01:57:56,269 >> I THINK THAT'S ONE OF THE 3462 01:57:56,335 --> 01:58:00,640 REASONS WHY HE WITH WE PUT OUTI 3463 01:58:00,706 --> 01:58:03,276 AS WELL, TRIED TO DISSEMINATE TO 3464 01:58:03,342 --> 01:58:04,911 TRAINEES AND COMMUNITY PARTNERS 3465 01:58:04,977 --> 01:58:06,746 AS WELL, AND I THINK THE COMPASS 3466 01:58:06,813 --> 01:58:07,814 PROGRAM IS REALLY THAT FIRST 3467 01:58:07,880 --> 01:58:09,048 KIND OF PROGRAM TO REALLY SHOW 3468 01:58:09,115 --> 01:58:10,750 WHEN WE'RE THINKING ABOUT 3469 01:58:10,817 --> 01:58:11,584 STRUCTURAL INTERVENTIONS, WHAT 3470 01:58:11,651 --> 01:58:13,085 IS IT GOING TO TAKE, AND WHAT 3471 01:58:13,152 --> 01:58:16,789 CAN WE LEARN FROM COMPASS AND 3472 01:58:16,856 --> 01:58:17,890 REALLY THINKING ABOUT HOW DO WE 3473 01:58:17,957 --> 01:58:19,192 TAKE THOSE LESSONS LEARNED TO 3474 01:58:19,258 --> 01:58:21,060 TRAIN THAT NEXT GENERATION. 3475 01:58:21,127 --> 01:58:22,462 I ALSO AM A FIRM BELIEVER WHERE 3476 01:58:22,528 --> 01:58:24,030 IT REALLY NEEDS TO BE INTEGRATED 3477 01:58:24,096 --> 01:58:27,600 INTO THE CURRICULUM IN A VERY 3478 01:58:27,667 --> 01:58:28,935 EARLY STAGE IN TERMS OF MEDICAL 3479 01:58:29,001 --> 01:58:30,636 SCHOOL OR PUBLIC HEALTH TRAINING 3480 01:58:30,703 --> 01:58:32,338 OR WHATNOT IN TERMS OF THE 3481 01:58:32,405 --> 01:58:34,073 IMPORTANCE OF THOSE STRUCTURAL 3482 01:58:34,140 --> 01:58:35,508 DETERMINANTS, AND THEN WHAT DO 3483 01:58:35,575 --> 01:58:36,442 WE DO ABOUT IT. 3484 01:58:36,509 --> 01:58:38,611 BUT I DO THINK COMPASS IS THAT 3485 01:58:38,678 --> 01:58:43,249 FIRST KIND OF -- IT'S A VERY BIG 3486 01:58:43,316 --> 01:58:47,720 PILOT, TO REALLY LEARN FROM THAT 3487 01:58:47,787 --> 01:58:49,021 IN TERMS OF WHAT IS NEEDED, AND 3488 01:58:49,088 --> 01:58:50,356 I THINK IN JUST A SHORT AMOUNT 3489 01:58:50,423 --> 01:58:52,959 OF TIME WE'VE ALREADY LEARNED A 3490 01:58:53,025 --> 01:58:55,261 LOT ABOUT THAT PIECE ABOUT 3491 01:58:55,328 --> 01:58:56,496 STRUCTURAL INTERVENTIONS BECAUSE 3492 01:58:56,562 --> 01:58:57,330 THEY'RE IN THE PLANNING PHASE 3493 01:58:57,396 --> 01:59:00,166 RIGHT NOW. 3494 01:59:00,233 --> 01:59:01,701 AND I THINK THAT'S REALLY WHY 3495 01:59:01,767 --> 01:59:02,802 OUR OFFICE PUT OUT THE RFI 3496 01:59:02,869 --> 01:59:05,404 BECAUSE WE ARE STRUGGLING WITH 3497 01:59:05,471 --> 01:59:06,639 THAT AND REALLY WANTED TO HEAR 3498 01:59:06,706 --> 01:59:07,473 FROM THE COMMUNITY, ESPECIALLY 3499 01:59:07,540 --> 01:59:08,841 OUR TRAINEE, IN TERMS OF LIKE 3500 01:59:08,908 --> 01:59:12,178 WHAT CAN WE DO BETTER AND HELP 3501 01:59:12,245 --> 01:59:14,280 SUPPORT YOUR CAREER TRAJECTORY. 3502 01:59:14,347 --> 01:59:16,148 BECAUSE WE'RE ALSO SEEING A HUGE 3503 01:59:16,215 --> 01:59:17,416 INTEREST FROM OUR TRAINEES IN 3504 01:59:17,483 --> 01:59:20,086 THIS TYPE OF WORK AS WELL. 3505 01:59:20,152 --> 01:59:21,587 >> I'M JUST GOING TO POINT OUT 3506 01:59:21,654 --> 01:59:24,090 WE'RE RUNNING A BIT OVER SO IF 3507 01:59:24,156 --> 01:59:26,492 PEOPLE CAN BE BRIEF WITH THEIR 3508 01:59:26,559 --> 01:59:29,562 QUESTIONS, WE'LL TRY TO GET TO 3509 01:59:29,629 --> 01:59:31,631 EVERYONE TO MARGUERITA. 3510 01:59:31,697 --> 01:59:31,831 JOEL. 3511 01:59:31,898 --> 01:59:37,703 >> I WANT TO APPLAUD YOUR WORK, 3512 01:59:37,770 --> 01:59:38,905 AND ECHO THE PREVIOUS COMMENTS. 3513 01:59:38,971 --> 01:59:40,206 FIRST I WANT TO ECHO THE 3514 01:59:40,273 --> 01:59:42,174 IMPORTANCE OF EVIDENCE-BASED 3515 01:59:42,241 --> 01:59:42,708 STRUCTURAL INTERVENTION. 3516 01:59:42,775 --> 01:59:45,111 I THINK ONE OF THE ACTUALLY 3517 01:59:45,177 --> 01:59:46,746 IRONIC CHALLENGES IS THERE'S SO 3518 01:59:46,812 --> 01:59:49,815 MUCH INTEREST AND DESIRE FOR 3519 01:59:49,882 --> 01:59:51,183 CONSCIOUSNESS-RAISING WORKSHOPS 3520 01:59:51,250 --> 01:59:53,252 WITHOUT EDUCATING TRAINEES ABOUT 3521 01:59:53,319 --> 01:59:54,186 THE IMPORTANCE OF STRUCTURAL 3522 01:59:54,253 --> 01:59:55,988 CHANGE AND HOW YOU ACTUALLY CAN 3523 01:59:56,055 --> 01:59:57,890 PROVIDE EVIDENCE FOR THAT, THAT 3524 01:59:57,957 --> 02:00:00,526 WILL ACTUALLY BE EFFECTIVE IN 3525 02:00:00,593 --> 02:00:02,061 CREATING CHANGE AS OPPOSED TO 3526 02:00:02,128 --> 02:00:05,031 JUST EFFECTIVE AT CREATING 3527 02:00:05,097 --> 02:00:06,132 CONSCIOUSNESS WHICH CAN CREATE 3528 02:00:06,198 --> 02:00:06,999 CHANGE. 3529 02:00:07,066 --> 02:00:08,401 EMPHASIS ON EMPIRICAL BASIS. 3530 02:00:08,467 --> 02:00:10,036 I ALSO WANT TO APPLAUD THE WORK 3531 02:00:10,102 --> 02:00:11,571 ON RURAL, AND I THINK THERE'S A 3532 02:00:11,637 --> 02:00:12,772 REAL CONNECTION BETWEEN THE GAPS 3533 02:00:12,838 --> 02:00:14,006 IN THE TRAINING ASSIGNMENTS THAT 3534 02:00:14,073 --> 02:00:16,409 YOU SHOWED IN RURAL HEALTH AND 3535 02:00:16,475 --> 02:00:18,911 THAT GOES RIGHT BACK TO CAPACITY 3536 02:00:18,978 --> 02:00:19,478 BUILDING. 3537 02:00:19,545 --> 02:00:20,880 THE RAPID CAPACITY IN THE 3538 02:00:20,947 --> 02:00:22,248 INSTITUTIONS IN THOSE AREAS IN 3539 02:00:22,315 --> 02:00:23,049 RURAL HEALTH TO ACTUALLY PROVIDE 3540 02:00:23,115 --> 02:00:24,283 THE TRAINING AND THE SCIENCE 3541 02:00:24,350 --> 02:00:26,218 THAT'S NEEDED, SO I REALLY WANT 3542 02:00:26,285 --> 02:00:27,119 TO EMPHASIZE THE IMPORTANCE OF 3543 02:00:27,186 --> 02:00:28,321 CAPACITY BUILDING IN YOUR 3544 02:00:28,387 --> 02:00:28,588 PORTFOLIO. 3545 02:00:28,654 --> 02:00:28,921 >> THANK YOU. 3546 02:00:28,988 --> 02:00:32,491 >> THANK YOU. 3547 02:00:32,558 --> 02:00:33,926 >> OH, ONE LAST QUESTION. 3548 02:00:33,993 --> 02:00:35,428 DO YOU FEEL THAT THERE'S 3549 02:00:35,494 --> 02:00:36,662 INTEREST IN CONGRESS IN THIS 3550 02:00:36,729 --> 02:00:37,530 WORK? 3551 02:00:37,597 --> 02:00:39,265 BECAUSE THE LONG TERM HERE, IT'S 3552 02:00:39,332 --> 02:00:40,800 SUCH A LONG-TERM GAME, AND 3553 02:00:40,866 --> 02:00:42,535 CONGRESS IS SO CONCERNED ABOUT 3554 02:00:42,602 --> 02:00:44,403 MENTAL HEALTH AND DISPARITIES IS 3555 02:00:44,470 --> 02:00:46,038 SUCH A BIG FACTOR IN THAT, SO I 3556 02:00:46,105 --> 02:00:47,239 JUST WANTED TO HIGHLIGHT THE 3557 02:00:47,306 --> 02:00:49,275 IMPORTANCE OF EDUCATING CONGRESS 3558 02:00:49,342 --> 02:00:49,775 IN THIS AREA. 3559 02:00:49,842 --> 02:00:50,643 >> ABSOLUTELY. 3560 02:00:50,710 --> 02:00:50,910 THANK YOU. 3561 02:00:50,977 --> 02:00:51,844 >> LET ME JUST ANSWER THAT 3562 02:00:51,911 --> 02:00:52,178 QUICKLY. 3563 02:00:52,244 --> 02:00:53,946 THE ANSWER IS YES, THERE IS 3564 02:00:54,013 --> 02:00:54,914 INTEREST IN CONGRESS IN 3565 02:00:54,981 --> 02:00:56,549 DISPARITIES RESEARCH IN GENERAL, 3566 02:00:56,616 --> 02:00:57,316 AND PARTICULARLY MENTAL HEALTH 3567 02:00:57,383 --> 02:01:02,588 DISPARITIES. 3568 02:01:02,655 --> 02:01:06,292 >> THANK YOU FOR A GREAT TALK. 3569 02:01:06,359 --> 02:01:07,593 GREAT TO SEE THE EMPHASIS YOUR 3570 02:01:07,660 --> 02:01:08,928 OFFICE IS HAVING. 3571 02:01:08,995 --> 02:01:10,529 ALSO PEOPLE WITH LIVED 3572 02:01:10,596 --> 02:01:11,631 EXPERIENCE IN MENTAL ILLNESS IN 3573 02:01:11,697 --> 02:01:13,499 THE CONCEPT OF DIVERSITY. 3574 02:01:13,566 --> 02:01:14,900 RELATED TO THAT I WAS WONDERING 3575 02:01:14,967 --> 02:01:16,168 WHAT YOUR THOUGHTS WERE ON 3576 02:01:16,235 --> 02:01:17,303 CREATING FUNDING OPPORTUNITIES 3577 02:01:17,370 --> 02:01:17,837 WHERE THERE WOULD BE A 3578 02:01:17,903 --> 02:01:19,372 REQUIREMENT TO HAVE PEOPLE WITH 3579 02:01:19,438 --> 02:01:21,574 LIVED EXPERIENCE AS PART OF THE 3580 02:01:21,641 --> 02:01:23,009 INVESTIGATOR TEAM SIMILAR TO 3581 02:01:23,075 --> 02:01:24,577 OTHER FUNDING BODIES LIKE THE 3582 02:01:24,644 --> 02:01:25,077 WELLCOME TRUST? 3583 02:01:25,144 --> 02:01:26,278 >> THOSE ARE ABSOLUTELY 3584 02:01:26,345 --> 02:01:27,580 DISCUSSIONS WE'RE HAVING ON A 3585 02:01:27,647 --> 02:01:29,448 REGULAR BASIS, BOTH WITHIN ODWD 3586 02:01:29,515 --> 02:01:32,618 AND THE DISPARITIES TEAM. 3587 02:01:32,685 --> 02:01:34,487 IN TERMS OF WHAT DO WE MEAN BY 3588 02:01:34,553 --> 02:01:36,022 COMMUNITY ENGAGEMENT, WHAT IS 3589 02:01:36,088 --> 02:01:36,322 THAT? 3590 02:01:36,389 --> 02:01:38,424 IS THAT JUST HEY, WE CHATTED 3591 02:01:38,491 --> 02:01:42,662 WITH SOMEONE ON THE STREET, AND 3592 02:01:42,728 --> 02:01:46,165 NOW IT'S COMMUNITY ENGAGED AND 3593 02:01:46,232 --> 02:01:47,900 HOW DO WE DEFINE THAT AT NIMH 3594 02:01:47,967 --> 02:01:50,336 AND WHAT IS THE ROLE OF LIVED 3595 02:01:50,403 --> 02:01:51,637 EXPERIENCE SO THOSE ARE THE 3596 02:01:51,704 --> 02:01:52,738 DEPTH OF CONVERSATIONS WE'RE 3597 02:01:52,805 --> 02:01:54,273 CURRENTLY HAVING AND I'D LOVE TO 3598 02:01:54,340 --> 02:01:55,908 BRING UPDATE TO YOU IN A COUPLE 3599 02:01:55,975 --> 02:01:56,108 YEARS. 3600 02:01:56,175 --> 02:01:56,909 >> PAMELA. 3601 02:01:56,976 --> 02:01:58,978 >> FIRST I JUST WANT TO GIVE YOU 3602 02:01:59,045 --> 02:02:00,179 A HUGE CONGRATULATIONS. 3603 02:02:00,246 --> 02:02:02,114 THIS IS A BEAUTIFUL PORTFOLIO 3604 02:02:02,181 --> 02:02:03,549 AND VERY EXCITING WORK THAT 3605 02:02:03,616 --> 02:02:04,817 YOU'RE LEADING AND YOUR TEAM AS 3606 02:02:04,884 --> 02:02:05,418 WELL. 3607 02:02:05,484 --> 02:02:07,053 SO CONGRATS TO ALL OF YOU. 3608 02:02:07,119 --> 02:02:08,054 I HAVE TWO QUESTIONS. 3609 02:02:08,120 --> 02:02:10,122 ONE IS JUST FOLLOWING UP ON THE 3610 02:02:10,189 --> 02:02:11,457 STRUCTURAL INTERVENTION PIECE, 3611 02:02:11,524 --> 02:02:13,959 WHICH IS AROUND -- IT SEEMS TO 3612 02:02:14,026 --> 02:02:15,294 ME AN IMPORTANT PART OF THAT 3613 02:02:15,361 --> 02:02:17,129 WOULD BE BOTH FUNDING FOR 3614 02:02:17,196 --> 02:02:18,230 CAPACITY BUILDING BUT ALSO 3615 02:02:18,297 --> 02:02:20,733 FUNDING FOR RESEARCH THAT HELPS 3616 02:02:20,800 --> 02:02:23,269 PEOPLE TO TRANSLATE SCIENCE TO 3617 02:02:23,335 --> 02:02:24,670 POLICY THAT GIVES PEOPLE THE 3618 02:02:24,737 --> 02:02:26,772 SKILLS TO COMMUNICATE THAT WELL 3619 02:02:26,839 --> 02:02:29,709 BECAUSE A LOT OF THIS IS 3620 02:02:29,775 --> 02:02:31,143 FIGURING OUT HOW DO YOU CHANGE 3621 02:02:31,210 --> 02:02:31,911 STRUCTURES, HOW DO YOU BRING 3622 02:02:31,977 --> 02:02:33,045 THAT EVIDENCE TO POLICY MAKERS 3623 02:02:33,112 --> 02:02:34,413 AND HOW DO YOU DO THAT IN A WAY 3624 02:02:34,480 --> 02:02:36,615 THAT CAN BE HEARD AND ACCEPTED 3625 02:02:36,682 --> 02:02:38,350 SO THINKING ABOUT THAT AS PART 3626 02:02:38,417 --> 02:02:39,785 OF THE REMIT FOR NIH AS WELL. 3627 02:02:39,852 --> 02:02:40,619 THE SECOND QUESTION I HAVE IS 3628 02:02:40,686 --> 02:02:43,389 THINKING ABOUT LOOKING AT THE 3629 02:02:43,456 --> 02:02:45,024 NIMH PORTFOLIO ON DISPARITIES 3630 02:02:45,091 --> 02:02:46,358 RESEARCH, CAN YOU LOOK AT THAT 3631 02:02:46,425 --> 02:02:51,030 AND DO SOME SYSTEMS ANALYSES TO 3632 02:02:51,097 --> 02:02:51,931 UNDERSTAND, OKAY, WHAT ARE THE 3633 02:02:51,997 --> 02:02:53,466 MOST IMPORTANT LEVERS THAT YOU 3634 02:02:53,532 --> 02:02:55,334 ACTUALLY NEED TO PUSH TO BE ABLE 3635 02:02:55,401 --> 02:02:58,037 TO GET THE OUTCOMES THAT WE WANT 3636 02:02:58,104 --> 02:02:59,371 FOR -- AT LEAST IF WE START WITH 3637 02:02:59,438 --> 02:03:01,240 DISPARITIES IN CARE, RIGHT, AND 3638 02:03:01,307 --> 02:03:03,309 MAYBE GO BY DIFFERENT DOMAINS OF 3639 02:03:03,375 --> 02:03:03,776 DISPARITIES. 3640 02:03:03,843 --> 02:03:05,077 BUT IT WOULD BE REALLY 3641 02:03:05,144 --> 02:03:06,512 INTERESTING TO DO SOME OF THAT 3642 02:03:06,579 --> 02:03:07,713 LOOKING AT THE COMPLEXITIES OF 3643 02:03:07,780 --> 02:03:09,281 THE PORTFOLIO AND THE SCIENCE TO 3644 02:03:09,348 --> 02:03:10,382 FIGURE OUT WHERE -- 3645 02:03:10,449 --> 02:03:11,650 >> I'M REALLY GLAD YOU BROUGHT 3646 02:03:11,717 --> 02:03:14,587 THAT UP BECAUSE DR. JULIETTE 3647 02:03:14,653 --> 02:03:16,655 MCCLENDON IS DOING THAT AS WE 3648 02:03:16,722 --> 02:03:17,990 SPEAK, WITH SOME HELP WITH 3649 02:03:18,057 --> 02:03:19,091 INTERNS AND STUFF LIKE THAT, BUT 3650 02:03:19,158 --> 02:03:20,726 THAT IS ONE OF THE REASONS WHY 3651 02:03:20,793 --> 02:03:24,130 WE RECRUITED JULIETTE, IS REALLY 3652 02:03:24,196 --> 02:03:26,932 THINKING ABOUT THAT STRUCTURAL 3653 02:03:26,999 --> 02:03:28,167 PIECE, AND SO THEY'RE DOING A 3654 02:03:28,234 --> 02:03:29,568 DEEP DIVE RIGHT NOW IN OUR 3655 02:03:29,635 --> 02:03:30,469 PORTFOLIO, SO THANK YOU FOR 3656 02:03:30,536 --> 02:03:30,669 THAT. 3657 02:03:30,736 --> 02:03:31,403 >> GREAT. 3658 02:03:31,470 --> 02:03:32,171 GREAT. 3659 02:03:32,238 --> 02:03:34,006 AND THAT MIGHT JUST BE ANOTHER 3660 02:03:34,073 --> 02:03:35,608 REALLY LOOKING AT SYSTEMS 3661 02:03:35,674 --> 02:03:37,176 ANALYSES, RIGHT, SYSTEMS 3662 02:03:37,243 --> 02:03:39,712 RESEARCH AS PART OF DISPARITIES 3663 02:03:39,779 --> 02:03:39,979 RESEARCH? 3664 02:03:40,045 --> 02:03:42,381 >> EXACTLY. 3665 02:03:42,448 --> 02:03:43,549 >> VELMA. 3666 02:03:43,616 --> 02:03:45,584 >> I, TOO, WANT TO ECHO, THIS 3667 02:03:45,651 --> 02:03:47,019 PORTFOLIO IS REALLY ENCOURAGING. 3668 02:03:47,086 --> 02:03:48,988 I HAVE ONE -- I GUESS TWO 3669 02:03:49,054 --> 02:03:49,555 QUESTIONS. 3670 02:03:49,622 --> 02:03:52,525 ONE IS, THE SELECTION OF DREXEL 3671 02:03:52,591 --> 02:03:54,927 AS COORDINATING CENTER IS ONE. 3672 02:03:54,994 --> 02:03:55,561 OR MAYBE THREE. 3673 02:03:55,628 --> 02:03:58,030 AND THE OTHER ONE -- WHICH YOU 3674 02:03:58,097 --> 02:03:58,664 CAN ANSWER LATER. 3675 02:03:58,731 --> 02:04:00,533 THE OTHER ONE IS THE ENGAGEMENT 3676 02:04:00,599 --> 02:04:02,401 OF HBCUs IN THE PROCESS OF 3677 02:04:02,468 --> 02:04:05,771 ADDRESSING ISSUES OF DISPARITY 3678 02:04:05,838 --> 02:04:07,306 IN WORKFORCE TRAINING, AND THEN 3679 02:04:07,373 --> 02:04:08,841 WAYS IN WHICH THERE MIGHT BE 3680 02:04:08,908 --> 02:04:14,213 SOME ACCOUNTABILITY TO NIH GRANT 3681 02:04:14,280 --> 02:04:16,182 HOLDERS IN UNIVERSITIES THAT 3682 02:04:16,248 --> 02:04:20,653 AREN'T INCLUDING DIVERSITY 3683 02:04:20,719 --> 02:04:23,656 SUPPLEMENTS BECAUSE THAT'S ONE 3684 02:04:23,722 --> 02:04:24,757 WAY -- HAVE SOME TYPE OF 3685 02:04:24,824 --> 02:04:25,624 REQUIREMENT THAT PEOPLE SHOULD 3686 02:04:25,691 --> 02:04:27,459 REALLY BE THOUGHTFUL ABOUT 3687 02:04:27,526 --> 02:04:31,230 INCLUDING DIVERSE POPULATIONS 3688 02:04:31,297 --> 02:04:32,498 FOR SUPPLEMENTS, AND YOU CAN 3689 02:04:32,565 --> 02:04:33,399 RESPOND LATER BECAUSE THERE ARE 3690 02:04:33,465 --> 02:04:34,233 LOTS OF QUESTIONS. 3691 02:04:34,300 --> 02:04:36,368 >> LET ME QUICKLY RESPOND. 3692 02:04:36,435 --> 02:04:38,003 WE CAN'T COMMENT ON THE 3693 02:04:38,070 --> 02:04:39,538 SELECTION PROCESS, EXCEPT TO SAY 3694 02:04:39,605 --> 02:04:43,242 THAT IT WAS ONE THAT WAS 3695 02:04:43,309 --> 02:04:44,243 RIGOROUS INVOLVED OUTSIDE 3696 02:04:44,310 --> 02:04:44,577 REVIEW. 3697 02:04:44,643 --> 02:04:45,878 JOEL. 3698 02:04:45,945 --> 02:04:47,213 NOT JOEL. 3699 02:04:47,279 --> 02:04:47,513 MARGUERITA. 3700 02:04:47,580 --> 02:04:48,414 THANK YOU. 3701 02:04:48,480 --> 02:04:50,249 I KNEW IT WAS OVER THERE 3702 02:04:50,316 --> 02:04:53,786 SOMEWHERE. 3703 02:04:53,853 --> 02:04:55,955 >> THE OREGON CONTINGENT. 3704 02:04:56,021 --> 02:04:57,590 WHAT I WAS GOING TO SAY HAS BEEN 3705 02:04:57,656 --> 02:05:00,893 COVERED MOSTLY, BUT I JUST ALSO 3706 02:05:00,960 --> 02:05:03,963 WANTED TO ECHO OR I GUESS NOT 3707 02:05:04,029 --> 02:05:04,730 ECHO, ONE OF THE THINGS THAT 3708 02:05:04,797 --> 02:05:06,265 WE'VE BEEN DOING AT OUR 3709 02:05:06,332 --> 02:05:08,033 INSTITUTION AS YOU THINK ABOUT 3710 02:05:08,100 --> 02:05:09,902 CENTERING HEALTH EQUITY IS 3711 02:05:09,969 --> 02:05:12,104 REALLY THINKING ABOUT HOW WE 3712 02:05:12,171 --> 02:05:14,373 TALK ABOUT PEOPLE, AND SO YOU 3713 02:05:14,440 --> 02:05:16,475 ALL MAY ALREADY BE DOING SOME OF 3714 02:05:16,542 --> 02:05:19,511 THIS INTERNAL WORK, BUT JUST 3715 02:05:19,578 --> 02:05:20,713 ELEVATING THIS IDEA THAT 3716 02:05:20,779 --> 02:05:22,047 OFTENTIMES WHEN WE TALK ABOUT 3717 02:05:22,114 --> 02:05:24,884 HEALTH DISPARITIES, WE 3718 02:05:24,950 --> 02:05:26,752 PATHOLOGIZE PEOPLE AND WE DON'T 3719 02:05:26,819 --> 02:05:29,855 USE FIRST-PERSON LANGUAGE, SO 3720 02:05:29,922 --> 02:05:35,160 THAT -- SO CENTERING HEALTH 3721 02:05:35,227 --> 02:05:37,930 EQUITY OFTENTIMES REQUIRES US TO 3722 02:05:37,997 --> 02:05:39,298 BE INTROSPECTIVE ABOUT HOW WE'RE 3723 02:05:39,365 --> 02:05:39,765 TALKING ABOUT PEOPLE. 3724 02:05:39,832 --> 02:05:42,334 >> I COULDN'T AGREE MORE. 3725 02:05:42,401 --> 02:05:49,308 >> JOIN ME IN THANKING 3726 02:05:49,375 --> 02:05:49,775 DR. BORBA. 3727 02:05:49,842 --> 02:05:51,176 NEXT WE'RE GOING TO HEAR FROM 3728 02:05:51,243 --> 02:05:53,712 THE COUNCIL WORK GROUP ON HIGH 3729 02:05:53,779 --> 02:05:54,813 DIMENSIONAL DATA, A PRESENTATION 3730 02:05:54,880 --> 02:05:58,083 OF THEIR RECOMMENDATIONS FOR 3731 02:05:58,150 --> 02:05:59,952 YOUR APPROVAL. 3732 02:06:00,019 --> 02:06:02,788 PLEASE JOIN ME IN VIRTUALLY 3733 02:06:02,855 --> 02:06:05,557 WELCOMING DRS. LAURA ALMASY AND 3734 02:06:05,624 --> 02:06:11,096 DAVE DAMIEN FAIR. 3735 02:06:11,163 --> 02:06:12,865 THEY'VE BEEN CO-CHAIRING A WORK 3736 02:06:12,932 --> 02:06:14,300 GROUP THAT STARTED ABOUT A YEAR 3737 02:06:14,366 --> 02:06:16,468 AGO COVERING THE TOPIC OF HIGH 3738 02:06:16,535 --> 02:06:17,803 DIMENSIONAL DATASETS AND ASKING 3739 02:06:17,870 --> 02:06:21,407 FOR RECOMMENDATIONS THAT WE CAN 3740 02:06:21,473 --> 02:06:23,142 ADOPT FROM A FUNDING PERSPECTIVE 3741 02:06:23,208 --> 02:06:27,546 TO ENSURE RIGOR AND APPROPRIATE 3742 02:06:27,613 --> 02:06:31,050 USE OF THE DATASET AND 3743 02:06:31,116 --> 02:06:32,151 APPROPRIATE DESIGN AND 3744 02:06:32,217 --> 02:06:32,484 EXPERIMENTS. 3745 02:06:32,551 --> 02:06:34,320 I CHARGED THIS WORKING GROUP TO 3746 02:06:34,386 --> 02:06:34,887 DEVELOP RECOMMENDATIONS 3747 02:06:34,954 --> 02:06:36,188 REGARDING CONCEPTUAL FRAME WORKS 3748 02:06:36,255 --> 02:06:38,924 AND EXPERIMENTAL ANALYTICAL 3749 02:06:38,991 --> 02:06:40,693 DESIGNS FOR EXPERIMENTS USING 3750 02:06:40,759 --> 02:06:41,994 THESE HIGH DIMENSIONAL DATASETS. 3751 02:06:42,061 --> 02:06:43,796 THEY HAVE MET DILIGENTLY OVER 3752 02:06:43,862 --> 02:06:45,798 THE PAST YEAR AND DEVELOPED 3753 02:06:45,864 --> 02:06:46,765 SERIOUS RECOMMENDATIONS THAT ARE 3754 02:06:46,832 --> 02:06:48,367 GOING TO BE REPORTED IN BRIEF TO 3755 02:06:48,434 --> 02:06:49,234 YOU TODAY. 3756 02:06:49,301 --> 02:06:53,272 ALSO YOU'VE BEEN PROVIDED WITH A 3757 02:06:53,339 --> 02:06:54,707 DRAFT COPY OF THEIR 3758 02:06:54,773 --> 02:06:55,307 RECOMMENDATIONS IN ADVANCE OF 3759 02:06:55,374 --> 02:06:56,241 THE MEETING WHICH YOU HOPEFULLY 3760 02:06:56,308 --> 02:06:58,010 HAVE HAD A CHANCE TO REVIEW. 3761 02:06:58,077 --> 02:07:01,413 DR. FAIR IS GOING TO PROVIDE AN 3762 02:07:01,480 --> 02:07:04,016 OVERVIEW AND WILL ENGAGE IN 3763 02:07:04,083 --> 02:07:05,551 DISCUSSION TO SEE IF THERE ARE 3764 02:07:05,617 --> 02:07:06,685 ANY RECOMMENDATIONS OR CHANGES 3765 02:07:06,752 --> 02:07:09,288 TO THE DRAFT AND HOPEFULLY 3766 02:07:09,355 --> 02:07:10,055 ACCEPTANCE OF THESE 3767 02:07:10,122 --> 02:07:14,960 RECOMMENDATIONS. 3768 02:07:15,027 --> 02:07:16,228 I'LL TURN IT OVER TO DAMIEN. 3769 02:07:16,295 --> 02:07:16,729 >> OKAY. 3770 02:07:16,795 --> 02:07:22,001 CAN YOU ALL HEAR ME? 3771 02:07:22,067 --> 02:07:23,068 >> YES, WE CAN. 3772 02:07:23,135 --> 02:07:23,969 >> OKAY. 3773 02:07:24,036 --> 02:07:25,270 SO MY -- FIRST OF ALL MY BLOOD 3774 02:07:25,337 --> 02:07:26,839 PRESSURE JUST WENT UP A LITTLE 3775 02:07:26,905 --> 02:07:30,943 BIT AS MY POSTDOC MENTOR JOEL IS 3776 02:07:31,010 --> 02:07:33,078 IN THE CROWD SO I HAVE TO 3777 02:07:33,145 --> 02:07:36,215 PERFORM, YOU KNOW. 3778 02:07:36,281 --> 02:07:37,349 BUT THANKS FOR HAVING US, I'M 3779 02:07:37,416 --> 02:07:39,852 GLAD TO SPEAK ABOUT OUR 3780 02:07:39,918 --> 02:07:41,920 EXPERIENCE IN SOME OF THE IDEAS 3781 02:07:41,987 --> 02:07:43,055 THAT CAME YOU THE FROM THIS 3782 02:07:43,122 --> 02:07:44,690 WORKING GROUP, OBVIOUSLY AN 3783 02:07:44,757 --> 02:07:45,891 EXTREMELY IMPORTANT TOPIC FOR 3784 02:07:45,958 --> 02:07:48,961 NIMH AND REALLY ALL OF OUR 3785 02:07:49,028 --> 02:07:50,929 SCIENCE, SO WE'LL GO THROUGH A 3786 02:07:50,996 --> 02:07:52,031 FEW, HOPEFULLY THIS WON'T TAKE 3787 02:07:52,097 --> 02:07:55,768 TOO LONG, AND LAURA AND I ARE 3788 02:07:55,834 --> 02:07:56,869 HERE ONLINE TO ANSWER SOME 3789 02:07:56,935 --> 02:07:57,136 QUESTIONS. 3790 02:07:57,202 --> 02:07:58,837 SO THE BACKGROUND HERE, OF 3791 02:07:58,904 --> 02:08:01,473 COURSE, IS THAT AS WE'VE 3792 02:08:01,540 --> 02:08:03,909 ADVANCED OVER THE LAST SEVERAL 3793 02:08:03,976 --> 02:08:07,479 DDECADES, OUR DATA HAS BECOME A 3794 02:08:07,546 --> 02:08:09,948 LOT BIGGER, A LOT MORE 3795 02:08:10,015 --> 02:08:10,616 MULTIDIMENSIONAL, A LOT MORE 3796 02:08:10,682 --> 02:08:11,383 COMPLEX. 3797 02:08:11,450 --> 02:08:12,351 WE'RE STUDYING DIFFERENT TYPES 3798 02:08:12,418 --> 02:08:15,854 OF RELATIONSHIPS. 3799 02:08:15,921 --> 02:08:17,523 IT'S GETTING REALLY COMPLICATED. 3800 02:08:17,589 --> 02:08:18,724 THE ISSUE IS THAT SOME OF OUR 3801 02:08:18,791 --> 02:08:19,792 CURRENT STANDARDS THAT WERE 3802 02:08:19,858 --> 02:08:22,761 REALLY PROBABLY ADOPTED FROM 3803 02:08:22,828 --> 02:08:26,732 PRIOR TO THIS TIME, ARE 3804 02:08:26,799 --> 02:08:27,733 SOMETIMES INEFFICIENT FOR 3805 02:08:27,800 --> 02:08:29,134 ENSURING SOME OF THE MORE ROBUST 3806 02:08:29,201 --> 02:08:31,470 AND REPRODUCIBLE OR 3807 02:08:31,537 --> 02:08:32,771 GENERALIZABLE RESULTS, THINGS 3808 02:08:32,838 --> 02:08:34,506 THAT WE ARE THRIVING TO DO. 3809 02:08:34,573 --> 02:08:36,041 SO PROBABLY THE MORE RECENT 3810 02:08:36,108 --> 02:08:37,943 EXAMPLE THAT I'M MORE -- WHAT 3811 02:08:38,010 --> 02:08:39,678 I'VE BEEN MORE USED TO AND BEEN 3812 02:08:39,745 --> 02:08:43,515 INVOLVED WITH IS HIGHLIGHTING 3813 02:08:43,582 --> 02:08:44,983 HOW BASIC RELATIONSHIPS BETWEEN 3814 02:08:45,050 --> 02:08:47,586 THE BRAIN OR BIOLOGY AND OTHER 3815 02:08:47,653 --> 02:08:49,455 CONDITIONS LIKE MENTAL HEALTH 3816 02:08:49,521 --> 02:08:53,192 CONDITIONS, YOU KNOW, COGNITIVE 3817 02:08:53,258 --> 02:08:54,193 BEHAVIORS, THEY TYPICALLY HAVE 3818 02:08:54,259 --> 02:08:55,294 SMALL EFFECT SIZES, WHICH MEANS 3819 02:08:55,360 --> 02:08:58,764 THAT YOU NEED LOTS AND LOTS OF 3820 02:08:58,831 --> 02:09:00,099 PARTICIPANTS TO GET A TRUE 3821 02:09:00,165 --> 02:09:00,332 RESULT. 3822 02:09:00,399 --> 02:09:01,667 AND SO DEPENDING ON THE STUDY 3823 02:09:01,733 --> 02:09:04,503 DESIGN OR THE OUTCOMES, YOU 3824 02:09:04,570 --> 02:09:06,305 KNOW, THE EFFECTS MAY APPEAR 3825 02:09:06,371 --> 02:09:07,806 LARGE IF YOU'RE UNDERPOWERED, 3826 02:09:07,873 --> 02:09:10,976 BUT THEY'RE ACTUALLY NOT REALLY 3827 02:09:11,043 --> 02:09:12,744 GENERALIZABLE AND DON'T PROVIDE 3828 02:09:12,811 --> 02:09:18,684 INSIGHTS ON THE TRUE EFFECTS. 3829 02:09:18,750 --> 02:09:25,557 SO SO TO ASSIST IN PRIORITIZINE 3830 02:09:25,624 --> 02:09:27,326 FUNDING OF RIGOROUS REPRODUCIBLE 3831 02:09:27,392 --> 02:09:28,494 RESEARCH, WE WERE CHARGED IN 3832 02:09:28,560 --> 02:09:29,228 FOUR SPECIFIC AREAS. 3833 02:09:29,294 --> 02:09:31,363 ONE, ENSURING THAT STATISTICAL 3834 02:09:31,430 --> 02:09:35,801 RIGOR AND ENHANCING -- ENSURING 3835 02:09:35,868 --> 02:09:38,537 STATISTICAL RIGOR AND ENHANCING 3836 02:09:38,604 --> 02:09:39,138 REPRODUCIBILITY, UNDERSTANDING 3837 02:09:39,204 --> 02:09:41,740 THE ROLE OF HYPOTHESES AND CON 3838 02:09:41,807 --> 02:09:42,941 CONCEPTUAL FRAME WORKS, GUIDING 3839 02:09:43,008 --> 02:09:44,576 STUDIES INVOLVING HIGH 3840 02:09:44,643 --> 02:09:45,878 DIMENSIONAL DATA, ASSESSING THE 3841 02:09:45,944 --> 02:09:48,447 CLINICAL UTILITY OF STUDIES. 3842 02:09:48,514 --> 02:09:50,616 EASY. 3843 02:09:50,682 --> 02:09:53,485 [LAUGHTER] 3844 02:09:53,552 --> 02:09:56,555 SO WE MET MONTHLY SINCE 3845 02:09:56,622 --> 02:09:58,624 JANUARY 2023. 3846 02:09:58,690 --> 02:10:00,692 WE HAVE SOME RECOMMENDATIONS 3847 02:10:00,759 --> 02:10:03,996 THAT KIND OF REVOLVE AROUND THE 3848 02:10:04,062 --> 02:10:05,030 STRUCTURE OF FIVE KIND OF 3849 02:10:05,097 --> 02:10:07,099 RESEARCH CATEGORIES AND 10 TOPIC 3850 02:10:07,166 --> 02:10:08,634 AREAS AND I'LL DESCRIBE HOW WE 3851 02:10:08,700 --> 02:10:10,102 GOT TO THERE SHORTLY. 3852 02:10:10,169 --> 02:10:12,271 NOW, I DON'T KNOW, IT'S LIKE 15 3853 02:10:12,337 --> 02:10:14,439 MONTHS OR 16 MONTHS SINCE WE 3854 02:10:14,506 --> 02:10:15,741 STARTED, SO YOU CAN TELL THAT 3855 02:10:15,807 --> 02:10:17,409 THIS WAS NOT ACTUALLY THAT EASY. 3856 02:10:17,476 --> 02:10:19,044 IN FACT, I THINK IT WAS PROBABLY 3857 02:10:19,111 --> 02:10:22,047 A LOT HARDER THAN I ANTICIPATED 3858 02:10:22,114 --> 02:10:23,148 GOING IN. 3859 02:10:23,215 --> 02:10:26,618 HERE IS OUR CLAN, OUR GROUP THAT 3860 02:10:26,685 --> 02:10:28,720 WAS MEETING MONTHLY. 3861 02:10:28,787 --> 02:10:31,823 AND THE FIRST THING THAT I THINK 3862 02:10:31,890 --> 02:10:33,892 WE RECOGNIZE AND ACKNOWLEDGE IS 3863 02:10:33,959 --> 02:10:36,094 THAT THERE'S JUST, YOU KNOW, 3864 02:10:36,161 --> 02:10:41,466 THINKING ABOUT THIS REALLY BROAD 3865 02:10:41,533 --> 02:10:42,901 CHARGE REQUIRED EXPERTISE FROM 3866 02:10:42,968 --> 02:10:45,304 LOTS OF DIFFERENT DISCIPLINES, 3867 02:10:45,370 --> 02:10:47,839 GENETICS, INFORMATICS, 3868 02:10:47,906 --> 02:10:48,707 NEUROSCIENCE, IMAGING, YOU CAN 3869 02:10:48,774 --> 02:10:51,043 SEE COMPUTATION AND STATS, 3870 02:10:51,109 --> 02:10:51,577 NUTRITION, INDUSTRY. 3871 02:10:51,643 --> 02:10:52,744 THERE'S JUST A WHOLE HOST OF 3872 02:10:52,811 --> 02:10:56,181 FOLKS WHO HAVE EXPERIENCED 3873 02:10:56,248 --> 02:10:57,583 SIMILAR ISSUES BUT HAVE 3874 02:10:57,649 --> 02:11:00,219 DIFFERENT LANGUAGES, DIFFERENT 3875 02:11:00,285 --> 02:11:01,220 CONCEPTUAL FRAME WORKS ABOUT HOW 3876 02:11:01,286 --> 02:11:02,321 TO THINK ABOUT SOME OF THESE 3877 02:11:02,387 --> 02:11:03,655 THINGS, SO PULLING EVERYBODY 3878 02:11:03,722 --> 02:11:05,023 TOGETHER INTO A COMMON FRAMEWORK 3879 02:11:05,090 --> 02:11:07,059 WAS ACTUALLY -- TOOK QUITE A BIT 3880 02:11:07,125 --> 02:11:08,493 OF TIME BECAUSE A LOT OF 3881 02:11:08,560 --> 02:11:11,096 DISCUSSION AROUND JUST MAKING 3882 02:11:11,163 --> 02:11:12,297 SURE THEY'RE ON THE SAME PAGE 3883 02:11:12,364 --> 02:11:13,632 FOR SOME VERY BASIC PRINCIPLES 3884 02:11:13,699 --> 02:11:14,666 THAT YOU THINK WOULD HAVE BEEN 3885 02:11:14,733 --> 02:11:15,968 EASY BUT ACTUALLY CAN BE QUITE 3886 02:11:16,034 --> 02:11:16,768 HARD. 3887 02:11:16,835 --> 02:11:21,273 WE WERE ALSO LUCKY TO HAVE 3888 02:11:21,340 --> 02:11:23,108 JONATHAN, LAURA AND TRACY KIND 3889 02:11:23,175 --> 02:11:27,145 OF DRAG US ALONG, YOU KNOW, IN 3890 02:11:27,212 --> 02:11:29,881 THIS PROCESS BECAUSE LIKE I 3891 02:11:29,948 --> 02:11:31,883 SAID, IT WAS QUITE DIFFICULT AND 3892 02:11:31,950 --> 02:11:34,086 IT REQUIRED A LOT OF FOLKS 3893 02:11:34,152 --> 02:11:36,154 COMING TOGETHER TO GET TO WHERE 3894 02:11:36,221 --> 02:11:40,659 WE'VE GOT. 3895 02:11:40,726 --> 02:11:42,461 NOW I'D SAY YOU CAN PROBABLY 3896 02:11:42,527 --> 02:11:44,062 THINK OF OUR RECOMMENDATIONS 3897 02:11:44,129 --> 02:11:45,597 PROBABLY ON TWO EXTREMES. 3898 02:11:45,664 --> 02:11:53,705 I THINK THERE WAS -- THERE WAS 3899 02:11:53,772 --> 02:11:55,240 A -- HOW DO I SAY, THERE'S A 3900 02:11:55,307 --> 02:11:56,775 DESIRE TO MAKE REALLY, REALLY 3901 02:11:56,842 --> 02:11:59,311 CRISP AND, LIKE, HEAVY-HANDED 3902 02:11:59,378 --> 02:12:00,012 RECOMMENDATIONS BUT AT THE END 3903 02:12:00,078 --> 02:12:02,180 OF THE DAY, THEY ENDED UP BEING 3904 02:12:02,247 --> 02:12:03,815 A LITTLE BIT MORE WATERED DOWN 3905 02:12:03,882 --> 02:12:04,683 BECAUSE IT WAS HARD TO GET 3906 02:12:04,750 --> 02:12:05,951 EVERYBODY TO REALLY, REALLY 3907 02:12:06,018 --> 02:12:07,352 AGREE ON SOME OF THE BIG 3908 02:12:07,419 --> 02:12:07,919 PRINCIPLES. 3909 02:12:07,986 --> 02:12:09,321 BUT WITH THAT SAID, WE THINK 3910 02:12:09,388 --> 02:12:10,455 THERE'S ENOUGH FRAMEWORK THERE 3911 02:12:10,522 --> 02:12:13,725 FOR THE NIH -- OR NIMH TO BE 3912 02:12:13,792 --> 02:12:15,027 ABLE TO THINK THROUGH AND MAKE 3913 02:12:15,093 --> 02:12:15,827 SOME RECOMMENDATIONS. 3914 02:12:15,894 --> 02:12:18,096 NOW THE FIRST ITEM OF BUSINESS 3915 02:12:18,163 --> 02:12:19,998 IN HELPING MAKE THESE 3916 02:12:20,065 --> 02:12:22,200 RECOMMENDATIONS WAS TO FIRST 3917 02:12:22,267 --> 02:12:23,602 THINK ABOUT RESEARCH DESIGN. 3918 02:12:23,669 --> 02:12:25,837 IN OTHER WORDS, THAT INSTEAD OF 3919 02:12:25,904 --> 02:12:27,039 THINKING ABOUT THINGS LIKE 3920 02:12:27,105 --> 02:12:28,640 SAMPLE SIZE AND POWER AND ALL 3921 02:12:28,707 --> 02:12:30,108 THE ISSUES THAT I WAS NOTING 3922 02:12:30,175 --> 02:12:31,310 EARLIER, YOU CAN'T REALLY DO 3923 02:12:31,376 --> 02:12:33,178 THAT WITHOUT HAVING AN 3924 02:12:33,245 --> 02:12:34,379 UNDERSTANDING OF THE DESIGN OF 3925 02:12:34,446 --> 02:12:35,414 THE EXPERIMENT THAT YOU'RE 3926 02:12:35,480 --> 02:12:37,382 TRYING TO RUN. 3927 02:12:37,449 --> 02:12:38,784 SO THAT WAS THE FIRST ITEM OF 3928 02:12:38,850 --> 02:12:40,652 BUSINESS, TRYING TO LAY OUT NOT 3929 02:12:40,719 --> 02:12:42,754 AN EXHAUSTIVE BUT A PRETTY 3930 02:12:42,821 --> 02:12:43,655 COMMON FRAMEWORK FOR THE TYPES 3931 02:12:43,722 --> 02:12:47,225 OF STUDY DESIGNS. 3932 02:12:47,292 --> 02:12:49,895 SO THESE ARE THE FIVE CATEGORY 3933 02:12:49,961 --> 02:12:51,630 THE: EXPLORATORY OR DESCRIPTIVE 3934 02:12:51,697 --> 02:12:53,498 STUDIES WHICH ESSENTIALLY ASK 3935 02:12:53,565 --> 02:12:56,601 QUESTIONS ABOUT THE DATA ITSELF, 3936 02:12:56,668 --> 02:12:58,770 INFERENTIAL OR PREDICTIVE 3937 02:12:58,837 --> 02:12:59,971 STUDIES, WHICH ARE PROBABLY THE 3938 02:13:00,038 --> 02:13:01,340 MAJORITY OF A LOT OF THE 3939 02:13:01,406 --> 02:13:02,974 STUDIES, AT LEAST IN HUMAN 3940 02:13:03,041 --> 02:13:05,177 RESEARCH THAT WE SEE, WHERE 3941 02:13:05,243 --> 02:13:07,446 YOU'RE RELATING HIGH DIMENSIONAL 3942 02:13:07,512 --> 02:13:10,749 DATA TO SOME OTHER OUTCOME 3943 02:13:10,816 --> 02:13:14,019 VARIABLE, THEN THERE'S DAW SAL 3944 02:13:14,086 --> 02:13:17,556 INTERVENTION STUDIES, LONGITUDAL 3945 02:13:17,622 --> 02:13:20,192 OR SOME KIND OF INTERVENTION, 3946 02:13:20,258 --> 02:13:24,429 EXPLANATORY STUDIES, INVOLVING 3947 02:13:24,496 --> 02:13:25,597 USING DATA TO UNDERSTAND THE 3948 02:13:25,664 --> 02:13:27,666 MECHANISMS BY WHICH SYSTEM, 3949 02:13:27,733 --> 02:13:28,767 CIRCUITS AND INDIVIDUAL 3950 02:13:28,834 --> 02:13:29,968 COMPONENTS AND METHODS OF TOOL 3951 02:13:30,035 --> 02:13:31,069 DEVELOPMENT. 3952 02:13:31,136 --> 02:13:34,139 THEN FROM THERE, THESE OTHER 3953 02:13:34,206 --> 02:13:35,374 CATEGORIES, WHAT WE DECIDED TO 3954 02:13:35,440 --> 02:13:38,577 DO WAS ESSENTIALLY START TAKING 3955 02:13:38,643 --> 02:13:40,679 IN THAT CONTEXT OF THOSE 3956 02:13:40,746 --> 02:13:42,948 DIFFERENT TYPES OF STUDY 3957 02:13:43,014 --> 02:13:45,283 DESIGNS, SO WALKING THROUGH THE 3958 02:13:45,350 --> 02:13:47,252 STUDY PROCESS OR GRANT PROCESS 3959 02:13:47,319 --> 02:13:49,020 STARTING WITH, YOU KNOW, GOALS 3960 02:13:49,087 --> 02:13:51,089 AND HYPOTHESES AND MOVING ALONG 3961 02:13:51,156 --> 02:13:53,759 THROUGH, YOU KNOW, ANALYSES, 3962 02:13:53,825 --> 02:13:54,860 METHODS, OUTCOMES, THINGS OF 3963 02:13:54,926 --> 02:13:57,796 THAT NATURE. 3964 02:13:57,863 --> 02:13:59,164 SO SO I'M GOING TO GO THROUGH 3965 02:13:59,231 --> 02:14:01,666 JUST A HANDFUL OF SOME OF WHAT 3966 02:14:01,733 --> 02:14:02,834 THE GROUP CAME UP WITH ON EACH 3967 02:14:02,901 --> 02:14:04,703 ONE OF THOSE 10 TOPIC AREAS FOR 3968 02:14:04,770 --> 02:14:05,637 RECOMMENDATIONS ALONG THAT STUDY 3969 02:14:05,704 --> 02:14:09,374 PROCESS. 3970 02:14:09,441 --> 02:14:10,809 SO ON GOALS, AIMS AND 3971 02:14:10,876 --> 02:14:11,109 HYPOTHESES. 3972 02:14:11,176 --> 02:14:13,145 THIS WAS A FUN ONE TO DISCUSS 3973 02:14:13,211 --> 02:14:15,981 BECAUSE AGAIN, EVEN SOME OF THE 3974 02:14:16,047 --> 02:14:17,516 BASIC THINGS YOU THINK ARE 3975 02:14:17,582 --> 02:14:18,917 COMMON ACROSS GROUPS WERE NOT 3976 02:14:18,984 --> 02:14:20,752 ALWAYS CONSISTENTLY AGREED UPON 3977 02:14:20,819 --> 02:14:22,821 WHAT THEY MEANT, BUT WE ALL 3978 02:14:22,888 --> 02:14:24,222 AGREED THAT HYPOTHESES CAN BE 3979 02:14:24,289 --> 02:14:25,891 USEFUL AND SOMETIMES ESSENTIAL 3980 02:14:25,957 --> 02:14:29,060 FOR FORMULATING CONCEPTIONS IN 3981 02:14:29,127 --> 02:14:30,662 AWARDS, NOT ALWAYS REQUIRED 3982 02:14:30,729 --> 02:14:31,897 PARTICULARLY FOR DESCRIPTIVE 3983 02:14:31,963 --> 02:14:35,233 SPHU DIS AND TSTUDIES AND THINGT 3984 02:14:35,300 --> 02:14:37,335 NATURE BUT THEY CAN BE HELPFUL 3985 02:14:37,402 --> 02:14:38,904 IN NARROWING SCOPE PARTICULARLY 3986 02:14:38,970 --> 02:14:41,173 AMONG HIGH DIMENSIONAL FEATURES 3987 02:14:41,239 --> 02:14:43,074 BUT ALL ASPECTS OF THE RESEARCH 3988 02:14:43,141 --> 02:14:45,844 DESIGN SHOULD BE WELL JUSTIFIED 3989 02:14:45,911 --> 02:14:46,711 AND PREREGISTRATION PLANS IN 3990 02:14:46,778 --> 02:14:51,316 GRANTS MAY BE HELPFUL FOR 3991 02:14:51,383 --> 02:14:53,852 INVESTIGATORS AND NIH TO THINK 3992 02:14:53,919 --> 02:14:54,753 ABOUT. 3993 02:14:54,820 --> 02:14:56,521 ONE OF THE -- I'M GOING TO KEEP 3994 02:14:56,588 --> 02:14:57,589 MOVING ON TO MAKE SURE WE HIT 3995 02:14:57,656 --> 02:15:05,263 TIME. 3996 02:15:05,330 --> 02:15:09,668 ON EXPERIMENTAL DESIGN, THE 3997 02:15:09,734 --> 02:15:13,939 GRANTS, AN INVESTIGATOR SHOULD 3998 02:15:14,005 --> 02:15:15,707 CLEARLY STATE THEIR PROPOSED 3999 02:15:15,774 --> 02:15:17,075 EXPERIMENTAL DESIGN, CRITICAL 4000 02:15:17,142 --> 02:15:18,810 FOR EVALUATING PROPERLY SAMPLE 4001 02:15:18,877 --> 02:15:21,646 SIZES, POWER, THINGS OF THAT 4002 02:15:21,713 --> 02:15:22,314 NATURE. 4003 02:15:22,380 --> 02:15:23,682 IT'S NOT ALWAYS THE CASE. 4004 02:15:23,748 --> 02:15:26,318 IT'S STUDY THAT THE STUDY DESIGN 4005 02:15:26,384 --> 02:15:28,820 PROVIDED JUSTIFICATION FOR 4006 02:15:28,887 --> 02:15:29,855 HYPOTHESIS-FREE APPROACHES SUCH 4007 02:15:29,921 --> 02:15:31,590 AS THE EXPLORATORY DESCRIPTIVE 4008 02:15:31,656 --> 02:15:38,029 STUDIES THAT I WAS DESCRIBING. 4009 02:15:38,096 --> 02:15:39,197 SO WHEN THE DATA ARE COLLECTED 4010 02:15:39,264 --> 02:15:43,134 WITH THE EXPECTATION OF DOING 4011 02:15:43,201 --> 02:15:44,336 INFERENTIAL OR PREDICTIVE 4012 02:15:44,402 --> 02:15:45,604 STATISTICS, THE STUDY DESIGN 4013 02:15:45,670 --> 02:15:46,671 SHOULD BE ALIGNED WITH THE 4014 02:15:46,738 --> 02:15:48,306 SPECIFIC OBJECTIVE. 4015 02:15:48,373 --> 02:15:50,008 THERE'S A LOT OF TALK ON SAMPLE 4016 02:15:50,075 --> 02:15:50,775 SIZES SO YOU'LL HEAR MORE ABOUT 4017 02:15:50,842 --> 02:15:53,411 THAT NOW, BUT SO WHEN YOU'RE 4018 02:15:53,478 --> 02:15:55,180 RUNNING AN INFERENCE, SAMPLE 4019 02:15:55,247 --> 02:15:59,784 SIZE SHOULD BE LARGE ENOUGH TO 4020 02:15:59,851 --> 02:16:05,490 PROVIDE - EVIDENCE OF MEANINGFUL 4021 02:16:05,557 --> 02:16:08,093 EFFECT IF ONE EXISTS, SIMILARLY, 4022 02:16:08,159 --> 02:16:09,027 FOR PREDICTION, THE SAMPLE MUST 4023 02:16:09,094 --> 02:16:10,662 BE LARGE ENOUGH TO EXCEED A 4024 02:16:10,729 --> 02:16:15,734 MEANINGFUL CRITERION OF 4025 02:16:15,800 --> 02:16:17,502 PREDICTIVE ACCURACY IF THE 4026 02:16:17,569 --> 02:16:19,804 PREDICTOR IS TRULY EFFECTIVE. 4027 02:16:19,871 --> 02:16:21,673 FOR INFERENTIALAL STATISTICS ON 4028 02:16:21,740 --> 02:16:23,441 HIGH DIMENSIONAL DATA, IF YOU'RE 4029 02:16:23,508 --> 02:16:26,778 TRYING TO IDENTIFY WSH YOU'RE 4030 02:16:26,845 --> 02:16:28,947 TRYING TO REALLY PULL OUT THE 4031 02:16:29,014 --> 02:16:30,015 RELATIONSHIPS TO GIVEN CELLS OR 4032 02:16:30,081 --> 02:16:32,584 ANY GIVEN PREDICTOR IN A HIGH 4033 02:16:32,651 --> 02:16:33,218 DIMENSIONAL DATA SET, THAT'S 4034 02:16:33,285 --> 02:16:34,786 GOING TO HAVE A HIGHLY DIFFERENT 4035 02:16:34,853 --> 02:16:37,422 DESIGN OR SAMPLE OR POWER NEEDS 4036 02:16:37,489 --> 02:16:38,857 THAN IF YOU'RE ACTUALLY JUST 4037 02:16:38,924 --> 02:16:41,493 PREDICTING AN OUT COME WITH A 4038 02:16:41,560 --> 02:16:42,294 MULTIDIMENSIONAL DATASET. 4039 02:16:42,360 --> 02:16:43,929 SO MAKING SURE THAT'S SUPER 4040 02:16:43,995 --> 02:16:45,096 CLEAR IN THE GRANTS, THAT'S THE 4041 02:16:45,163 --> 02:16:46,665 ONLY WAY THAT YOU CAN EVALUATE 4042 02:16:46,731 --> 02:16:52,604 THE QUALITY OF THE STUDY DESIGN. 4043 02:16:52,671 --> 02:16:54,472 A BIG ONE AND POWER AND SAMPLE 4044 02:16:54,539 --> 02:16:55,574 SIZE ESTIMATES, SO WHAT WE CAME 4045 02:16:55,640 --> 02:16:57,142 UP WITH IS THAT LARGE SAMPLE 4046 02:16:57,208 --> 02:16:58,777 SIZES ARE GENERALLY NECESSARY 4047 02:16:58,843 --> 02:16:59,978 FOR POPULATION-LEVEL 4048 02:17:00,045 --> 02:17:00,545 ASSOCIATIONS. 4049 02:17:00,612 --> 02:17:01,646 NOT ALWAYS BUT GENERALLY IT 4050 02:17:01,713 --> 02:17:03,782 TRUE. 4051 02:17:03,848 --> 02:17:05,951 THEY'RE OFTEN EXPLORATORY AND 4052 02:17:06,017 --> 02:17:07,786 DESCRIPTIVE. 4053 02:17:07,852 --> 02:17:11,790 AND IN STUDIES WI WHERE SMALL 4054 02:17:11,856 --> 02:17:13,325 EFFECT SIZES ARE TYPICAL. 4055 02:17:13,391 --> 02:17:16,661 MORE DESCRIPTIVE STUDY, CENTRAL 4056 02:17:16,728 --> 02:17:17,862 TENDENCIES, AVERAGE 4057 02:17:17,929 --> 02:17:18,830 DESCRIPTIONS, WE'VE SEEN A LOT 4058 02:17:18,897 --> 02:17:20,165 OF WORK COME OUT AT LEAST IN THE 4059 02:17:20,231 --> 02:17:22,367 BRAIN SPACE IN FUNCTIONAL 4060 02:17:22,434 --> 02:17:22,601 ANATOMY. 4061 02:17:22,667 --> 02:17:23,468 SOME INTERVENTIONAL STUDIES. 4062 02:17:23,535 --> 02:17:25,203 THEY OFTEN DON'T REQUIRE LARGE 4063 02:17:25,270 --> 02:17:25,670 SAMPLE SIZES. 4064 02:17:25,737 --> 02:17:28,306 IN FACT, THEY CAN BE VERY SMALL 4065 02:17:28,373 --> 02:17:30,175 IN MANY CASES. 4066 02:17:30,241 --> 02:17:31,943 SO AGAIN, UNDERSTANDING THE 4067 02:17:32,010 --> 02:17:33,345 DESIGN AND INTENT OF THE WORK IS 4068 02:17:33,411 --> 02:17:35,146 REALLY IMPORTANT FOR EVALUATING 4069 02:17:35,213 --> 02:17:42,120 THE QUALITY OF THE APPLICATION. 4070 02:17:42,187 --> 02:17:43,355 THE POWER APPLICATIONS AND 4071 02:17:43,421 --> 02:17:46,358 AWARDS SHOULD BE BASED ON KNOWN, 4072 02:17:46,424 --> 02:17:47,425 EMPIRICALLY GENERATED EFFECT 4073 02:17:47,492 --> 02:17:49,060 SIZES AND STANDARD ERRORS OR 4074 02:17:49,127 --> 02:17:50,528 PERCENT VARIANCE EXPLAINED, AND 4075 02:17:50,595 --> 02:17:51,630 IMPORTANTLY, WHEN THERE ARE NO 4076 02:17:51,696 --> 02:17:52,731 PREVIOUSLY SUFFICIENTLY POWERED 4077 02:17:52,797 --> 02:17:54,299 DATA AVAILABLE FOR INVESTIGATORS 4078 02:17:54,366 --> 02:17:55,967 TO REFERENCE, POWER SHOULD BE 4079 02:17:56,034 --> 02:17:57,602 CONSIDERED ON A RANGE OF 4080 02:17:57,669 --> 02:17:58,603 PLAUSIBLE ESTIMATES AND EFFECT 4081 02:17:58,670 --> 02:18:00,238 SIZES. 4082 02:18:00,305 --> 02:18:04,309 AND AGAIN, IT SHOULD BE LEANING 4083 02:18:04,376 --> 02:18:05,844 ON HIGH POWER STUDIES FOR 4084 02:18:05,910 --> 02:18:08,380 GUIDANCE FOR THE CONSIDERATION 4085 02:18:08,446 --> 02:18:09,147 OF RANGES. 4086 02:18:09,214 --> 02:18:11,916 SO A LOT OF TIMES YOU'LL SEE IN 4087 02:18:11,983 --> 02:18:13,585 AWARDS WHERE THEY'RE LEVERAGING 4088 02:18:13,652 --> 02:18:16,521 EXISTING LITERATURE FOR 4089 02:18:16,588 --> 02:18:17,656 PREDICTING POWER AND THINGS OF 4090 02:18:17,722 --> 02:18:20,725 THAT NATURE, BUT -- AND THAT'S 4091 02:18:20,792 --> 02:18:24,029 THE WORK IN THE LITERATURE IS 4092 02:18:24,095 --> 02:18:25,530 ALSO WELL POWERED, EFFECTS ARE 4093 02:18:25,597 --> 02:18:27,332 OFTEN INFLATED FOR ALL SORTS OF 4094 02:18:27,399 --> 02:18:30,168 REASONS AND THAT CAN LEAD TO 4095 02:18:30,235 --> 02:18:31,503 ACTUALLY INSUFFICIENT POWER 4096 02:18:31,569 --> 02:18:33,071 STUDIES UNLESS YOU'RE BASING IT 4097 02:18:33,138 --> 02:18:34,606 ON STUDIES THAT ARE ACTUALLY 4098 02:18:34,673 --> 02:18:37,342 ALREADY POWERED. 4099 02:18:37,409 --> 02:18:41,212 ON MEASUREMENTS OF TRAITS AND 4100 02:18:41,279 --> 02:18:43,415 PHENOTYPES, SO JUST AS THE LARGE 4101 02:18:43,481 --> 02:18:45,917 SAMPLE SIZES CAN INCREASE POWER, 4102 02:18:45,984 --> 02:18:46,885 INCREASING MEASUREMENT PRECISION 4103 02:18:46,951 --> 02:18:47,852 IS ALSO REALLY IMPORTANT FOR 4104 02:18:47,919 --> 02:18:48,153 THAT. 4105 02:18:48,219 --> 02:18:49,688 SO THE QUALITY OF THE 4106 02:18:49,754 --> 02:18:52,157 PSYCHIATRIC TRAIT, THE PHENOTYPE 4107 02:18:52,223 --> 02:18:53,591 DATA IS A KEY DETERMINANT OF 4108 02:18:53,658 --> 02:18:55,927 RIGOR AND RELIABILITY, AS WELL 4109 02:18:55,994 --> 02:18:58,063 AS THE OTHER GENETICS AND BRAIN 4110 02:18:58,129 --> 02:18:59,764 IMAGING AND OTHER HIGH 4111 02:18:59,831 --> 02:19:00,732 DIMENSIONAL DATA, AND THAT 4112 02:19:00,799 --> 02:19:02,367 SHOULD BE REALLY EMPHASIZED IN 4113 02:19:02,434 --> 02:19:05,336 APPLICATIONS. 4114 02:19:05,403 --> 02:19:07,772 EVEN WHEN DEERCH IN COMMONLY 4115 02:19:07,839 --> 02:19:10,208 USED MEASURES THAT MAY NOT HAVE 4116 02:19:10,275 --> 02:19:12,277 HIGH RELIABILITY. 4117 02:19:12,343 --> 02:19:13,645 STUDIES SHOULD ALSO INCLUDE 4118 02:19:13,712 --> 02:19:14,946 SUFFICIENT BIOLOGICAL AND 4119 02:19:15,013 --> 02:19:17,248 TECHNICAL REPLICATES WHERE 4120 02:19:17,315 --> 02:19:18,483 APPLICABLE, AND INVESTIGATORS 4121 02:19:18,550 --> 02:19:20,351 SHOULD DESCRIBE HOW THE 4122 02:19:20,418 --> 02:19:21,886 ROBUSTNESS OF THE DATA 4123 02:19:21,953 --> 02:19:24,522 MEASUREMENTS WILL BE EVALUATED. 4124 02:19:24,589 --> 02:19:27,358 ON DIMENSIONALITY REDUCTION, 4125 02:19:27,425 --> 02:19:28,727 THIS WAS -- KIND OF WENT BACK 4126 02:19:28,793 --> 02:19:31,463 AND FORTH A LITTLE BIT, BUT THIS 4127 02:19:31,529 --> 02:19:33,064 IS JUST A QUICK ONE. 4128 02:19:33,131 --> 02:19:34,332 INVESTIGATORS SHOULD REALLY 4129 02:19:34,399 --> 02:19:36,601 PROVIDE DETAILS OF THE SPECIFICS 4130 02:19:36,668 --> 02:19:38,937 OF THE METHODS TO MAKE SURE THE 4131 02:19:39,003 --> 02:19:41,706 APPROACHES CAN BE REPLICATED AND 4132 02:19:41,773 --> 02:19:44,008 APPLIED INDEPENDENTLY. 4133 02:19:44,075 --> 02:19:45,744 ON INDEPENDENT REPLICATION AND 4134 02:19:45,810 --> 02:19:49,047 GENERALIZABILITY OF RESULTS. 4135 02:19:49,114 --> 02:19:50,749 SO BEST PRACTICES, YOU KNOW, 4136 02:19:50,815 --> 02:19:52,384 SHOULD BE HIGH PRIORITY OF 4137 02:19:52,450 --> 02:19:53,818 AWARDS SO INVESTIGATORS SHOULD 4138 02:19:53,885 --> 02:19:55,353 INCLUDE PLANS FOR REPLICATIONS, 4139 02:19:55,420 --> 02:19:58,223 YOU KNOW, AND TEST THE 4140 02:19:58,289 --> 02:19:58,723 GENERALIZABILITY IN THE 4141 02:19:58,790 --> 02:20:01,192 PROJECTS. 4142 02:20:01,259 --> 02:20:03,928 THAT WAS MOSTLY AGREED UPON 4143 02:20:03,995 --> 02:20:06,798 THROUGHOUT THE GROUP. 4144 02:20:06,865 --> 02:20:09,000 BEST PRACTICES INCLUDE PLANS FOR 4145 02:20:09,067 --> 02:20:10,635 REPLICATIONS AND TEST OF 4146 02:20:10,702 --> 02:20:12,070 GENERALIZABILITY THAT RELY ON 4147 02:20:12,137 --> 02:20:14,105 STUDIES THAT RELY ON HIGH 4148 02:20:14,172 --> 02:20:17,709 DIMENSIONAL DATA, AND 4149 02:20:17,776 --> 02:20:19,344 INVESTIGATORS SHOULD ALSO BE 4150 02:20:19,411 --> 02:20:21,479 SHARING PIPELINES AND ANALYTIC 4151 02:20:21,546 --> 02:20:23,982 TOOLS AND THINGS OF THAT NATURE. 4152 02:20:24,048 --> 02:20:25,650 TO ENSURE THAT REPRODUCIBILITY 4153 02:20:25,717 --> 02:20:30,355 IN RESEARCH. 4154 02:20:30,421 --> 02:20:32,757 ON PILOT STUDIES AND PRELIMINARY 4155 02:20:32,824 --> 02:20:33,792 DATA AND AWARDS. 4156 02:20:33,858 --> 02:20:37,929 SO ON THESE, OFTENTIMES WHEN 4157 02:20:37,996 --> 02:20:39,831 WE'RE LOOKING AT PILOT DATA, A 4158 02:20:39,898 --> 02:20:41,599 LOT OF THEM ARE UNDERPOWERED TO 4159 02:20:41,666 --> 02:20:45,303 BEGIN WITH. 4160 02:20:45,370 --> 02:20:49,007 AND SO YOU SHOULD BE APPROACHING 4161 02:20:49,073 --> 02:20:52,043 MEASURES OF EFFECT SIZE AND STA 4162 02:20:52,110 --> 02:20:52,811 STATISTICAL SIGNIFICANCE AND 4163 02:20:52,877 --> 02:20:55,380 THESE PILOT STUDIES SHOULD BE 4164 02:20:55,446 --> 02:20:56,481 APPROACHED -- IN MANY CASES YOU 4165 02:20:56,548 --> 02:20:57,582 PROBABLY SHOULDN'T BE SEEING 4166 02:20:57,649 --> 02:20:59,317 SIGNIFICANT RESULTS IF IT'S 4167 02:20:59,384 --> 02:21:00,285 UNDERPOWERED DATA. 4168 02:21:00,351 --> 02:21:03,221 SO THAT'S NOT NECESSARILY THE 4169 02:21:03,288 --> 02:21:09,027 CURRENT STANDARD, BUT STUDY 4170 02:21:09,093 --> 02:21:10,595 SECTIONS SHOULD BE EVALUATING 4171 02:21:10,662 --> 02:21:11,596 THE QUALITY OF THESE PRELIMINARY 4172 02:21:11,663 --> 02:21:12,363 STUDIES AND WHAT THEY'RE 4173 02:21:12,430 --> 02:21:13,665 ACTUALLY BEING USED FOR IN THE 4174 02:21:13,731 --> 02:21:14,232 AWARDS. 4175 02:21:14,299 --> 02:21:16,768 ON DATA SHARING, CODE AND 4176 02:21:16,835 --> 02:21:18,870 RESOURCE SHARING, IN THIS, 4177 02:21:18,937 --> 02:21:22,140 THERE'S A LOT OF ALREADY NIMH 4178 02:21:22,207 --> 02:21:23,374 AND NIH HAS DONE A LOT ALREADY 4179 02:21:23,441 --> 02:21:24,475 IN THIS SPACE. 4180 02:21:24,542 --> 02:21:26,544 SO WE KIND OF REITERATED SOME OF 4181 02:21:26,611 --> 02:21:28,313 THAT AND KIND OF TOOK IT A 4182 02:21:28,379 --> 02:21:29,314 LITTLE BIT FURTHER WITH SOME OF 4183 02:21:29,380 --> 02:21:30,748 THE CODE AND RESEARCH SHARING AS 4184 02:21:30,815 --> 02:21:33,818 WELL. 4185 02:21:33,885 --> 02:21:36,521 ON PUBLICATION PLANS, THERE WAS 4186 02:21:36,588 --> 02:21:37,956 A MIXED BAG, YOU KNOW, I WOULD 4187 02:21:38,022 --> 02:21:39,791 SAY IN THE GROUP, ON THE 4188 02:21:39,858 --> 02:21:44,929 IMPORTANCE OF PREREGISTRATION. 4189 02:21:44,996 --> 02:21:46,497 SO WHILE IT'S NOT NECESSARILY 4190 02:21:46,564 --> 02:21:48,733 REQUIRED, BUT PUTTING TOGETHER 4191 02:21:48,800 --> 02:21:50,468 IN AWARDS LIKE A PREREGISTRATION 4192 02:21:50,535 --> 02:21:51,769 PLAN WHICH SHOULD BE THOUGHT OF 4193 02:21:51,836 --> 02:21:54,305 AS A STRENGTH OF THE RESEARCH 4194 02:21:54,372 --> 02:21:55,540 APPROACH AND THEIR GENERAL 4195 02:21:55,607 --> 02:22:01,012 PUBLICATION PLANS. 4196 02:22:01,079 --> 02:22:03,114 THE ISSUES AROUND EARLY STAGE 4197 02:22:03,181 --> 02:22:06,084 INVESTIGATORS AND TRAINING 4198 02:22:06,150 --> 02:22:07,619 GRANTS, THIS WAS A HOT TOPIC 4199 02:22:07,685 --> 02:22:10,021 THAT WE SPENT MANY MEETINGS ON 4200 02:22:10,088 --> 02:22:13,992 BECAUSE AS YOU KNOW, TRAINING 4201 02:22:14,058 --> 02:22:16,194 GRANTS AND AWARDS FOR TRAINEES 4202 02:22:16,261 --> 02:22:19,364 COULD BE QUITE A BIT SMALLER IN 4203 02:22:19,430 --> 02:22:21,065 SIZE WITH REGARD TO RESOURCES, 4204 02:22:21,132 --> 02:22:23,268 SO GETTING ADEQUATELY POWERED 4205 02:22:23,334 --> 02:22:27,305 STUDIES IS NOT ALWAYS FEASIBLE. 4206 02:22:27,372 --> 02:22:33,678 SO THE SUGGESTED PRIORITIZING 4207 02:22:33,745 --> 02:22:34,579 PRIORITIES -- FOR RESEARCHERS 4208 02:22:34,646 --> 02:22:37,982 THAT USE REPOSITORIES IS REALLY 4209 02:22:38,049 --> 02:22:39,550 HIGHLY ENCOURAGED. 4210 02:22:39,617 --> 02:22:41,185 THERE SHOULD ALSO BE SUPPORT FOR 4211 02:22:41,252 --> 02:22:42,053 INVESTIGATORS TO COLLECT THEIR 4212 02:22:42,120 --> 02:22:48,459 OWN DATA, BUT IMPORTANTLY, THE 4213 02:22:48,526 --> 02:22:49,527 STUDY DESIGN SHOULD BE DESIGNED 4214 02:22:49,594 --> 02:22:53,197 IN A WAY THAT FACILITATE, YOU 4215 02:22:53,264 --> 02:23:00,505 KNOW, SMALLER END STU STUDIES BT 4216 02:23:00,571 --> 02:23:03,708 THE RESEARCH ALSO SHOULD BE 4217 02:23:03,775 --> 02:23:04,575 TAKEN INTO CONSIDERATION THE 4218 02:23:04,642 --> 02:23:05,610 TRAINING PURPOSES OF THE WORK, 4219 02:23:05,677 --> 02:23:07,045 IN SOME CASES YOU MAY HAVE TO 4220 02:23:07,111 --> 02:23:10,381 CHOOSE TO SUPPORT PROMISING 4221 02:23:10,448 --> 02:23:11,716 FOLKS THAT REQUIRE UNDERPOWERED 4222 02:23:11,783 --> 02:23:12,917 STUDIES OR THE STUDIES THAT NEED 4223 02:23:12,984 --> 02:23:14,452 TO BE COMBINED WITH OTHER 4224 02:23:14,519 --> 02:23:18,456 DATASETS. 4225 02:23:18,523 --> 02:23:19,857 I'M GOING TO END THERE TO TAKE 4226 02:23:19,924 --> 02:23:21,392 QUESTIONS FOR MYSELF AND LAURA. 4227 02:23:21,459 --> 02:23:22,860 I KNOW WE WENT A LITTLE BIT OVER 4228 02:23:22,927 --> 02:23:24,195 LAST SESSION SO TIME IS A LITTLE 4229 02:23:24,262 --> 02:23:24,729 BIT SHORT. 4230 02:23:24,796 --> 02:23:27,598 I JUST WANTED TO █AGAIN SAY 4231 02:23:27,665 --> 02:23:29,534 THANKS FOR REALLY QUITE AN 4232 02:23:29,600 --> 02:23:30,501 AMAZING LEARNING EXPERIENCE, YOU 4233 02:23:30,568 --> 02:23:32,804 KNOW, FOR THE LAST YEAR IN THIS 4234 02:23:32,870 --> 02:23:34,772 SPACE. 4235 02:23:34,839 --> 02:23:36,908 AND I DON'T KNOW WHAT LAURA 4236 02:23:36,975 --> 02:23:38,876 THINKS BUT I WAS ACTUALLY -- I 4237 02:23:38,943 --> 02:23:41,179 PRIDE MYSELF IN BEING BROAD IN 4238 02:23:41,245 --> 02:23:43,081 MY THINKING, IN HOW I SEARCH FOR 4239 02:23:43,147 --> 02:23:44,615 THINGS AND HOW I TRY TO REACH 4240 02:23:44,682 --> 02:23:46,584 OUT TO OTHER DIMENSIONS AND 4241 02:23:46,651 --> 02:23:48,386 OTHER DOMAINS THAT ARE OUTSIDE 4242 02:23:48,453 --> 02:23:50,688 OF MY WHEELHOUSE IN THE SCIENCE, 4243 02:23:50,755 --> 02:23:52,523 BUT I LEARNED QUITE QUICKLY, IN 4244 02:23:52,590 --> 02:23:54,492 FACT EVEN IN THE FIRST MONTH, 4245 02:23:54,559 --> 02:23:55,994 ABOUT HOW SIMILAR ISSUES ARE 4246 02:23:56,060 --> 02:23:57,195 BEING APPLIED IN ALL DIFFERENT 4247 02:23:57,261 --> 02:23:59,530 TYPES OF DOMAINS, PAPERS AND BIG 4248 02:23:59,597 --> 02:24:00,198 PUBLICATIONS THAT I DIDN'T EVEN 4249 02:24:00,264 --> 02:24:02,934 KNOW ABOUT AT ALL. 4250 02:24:03,001 --> 02:24:04,736 SO IT WAS QUITE A LEARNING 4251 02:24:04,802 --> 02:24:05,036 EXPERIENCE. 4252 02:24:05,103 --> 02:24:07,405 I REALLY APPRECIATE IT AND I 4253 02:24:07,472 --> 02:24:08,406 HOPE THAT THE RECOMMENDATION 4254 02:24:08,473 --> 02:24:10,008 THAT WE WERE ABLE TO PUT 4255 02:24:10,074 --> 02:24:13,378 TOGETHER CAN PROVIDE AT LEAST A 4256 02:24:13,444 --> 02:24:15,313 FRAMEWORK FOR HOW TO BE ABLE TO 4257 02:24:15,380 --> 02:24:16,881 EVALUATE AWARDS THAT COME IN TO 4258 02:24:16,948 --> 02:24:18,182 THE NIMH IN THE FUTURE. 4259 02:24:18,249 --> 02:24:28,359 THANK YOU. 4260 02:24:28,426 --> 02:24:30,261 >> LET ME ECHO MY THANKS TO THE 4261 02:24:30,328 --> 02:24:31,462 ENTIRE WORK GROUP AND ESPECIALLY 4262 02:24:31,529 --> 02:24:33,998 TO YOU AND LAURA FOR CHAIRING 4263 02:24:34,065 --> 02:24:38,202 IT, AND TO OUR NIMH STAFFERS WHO 4264 02:24:38,269 --> 02:24:39,303 WERE INVOLVED IN IT AS WELL. 4265 02:24:39,370 --> 02:24:40,505 AND WITH THAT, I WILL OPEN IT UP 4266 02:24:40,571 --> 02:24:42,006 AND I UNDERSTAND THAT LAURA 4267 02:24:42,073 --> 02:24:44,509 SCOTT, YOU'D LIKE TO KICK US OFF 4268 02:24:44,575 --> 02:24:47,812 WITH THE DISCUSSION. 4269 02:24:47,879 --> 02:24:48,579 >> THANKS VERY MUCH. 4270 02:24:48,646 --> 02:24:51,682 THAT WAS A GREAT SUMMARY OF THE 4271 02:24:51,749 --> 02:24:53,618 REPORT AND THE WORK THAT WENT IN 4272 02:24:53,684 --> 02:24:55,386 TO DOING IT. 4273 02:24:55,453 --> 02:24:57,055 SO AS DAMIEN SAID, THERE WERE 4274 02:24:57,121 --> 02:24:58,923 MANY DIFFERENT OPINIONS ON SOME 4275 02:24:58,990 --> 02:25:02,126 OF THE ISSUES, AND I'M HAPPY TO 4276 02:25:02,193 --> 02:25:04,629 SEE IT'S COME TO FRUITION FOR 4277 02:25:04,695 --> 02:25:10,835 CONSIDERATION OF ADOPTION. 4278 02:25:10,902 --> 02:25:12,236 I WANT TO TAKE JUST A MOMENT TO 4279 02:25:12,303 --> 02:25:13,104 TALK ABOUT THE LIFE OF THE 4280 02:25:13,171 --> 02:25:14,138 DOCUMENT AS WE GO FORWARD 4281 02:25:14,205 --> 02:25:16,074 BECAUSE IT REALLY HAS TWO OR 4282 02:25:16,140 --> 02:25:17,341 THREE POTENTIAL AUDIENCES. 4283 02:25:17,408 --> 02:25:19,210 SO ONE IS THE NIMH PROGRAM 4284 02:25:19,277 --> 02:25:20,411 OFFICERS WHO WOULD USE THE 4285 02:25:20,478 --> 02:25:21,646 DOCUMENT TO AID IN THEIR 4286 02:25:21,712 --> 02:25:23,948 EVALUATION OF PROPOSALS. 4287 02:25:24,015 --> 02:25:26,117 ANOTHER IS MENTAL HEALTH FOCUSED 4288 02:25:26,184 --> 02:25:27,718 RESEARCHERS ARE APPLYING FOR 4289 02:25:27,785 --> 02:25:29,020 FUNDING AND LOOKING FOR GUIDANCE 4290 02:25:29,087 --> 02:25:33,191 BEFORE SUBMITTING OR 4291 02:25:33,257 --> 02:25:33,724 RESUBMITTING RESPONSE TO 4292 02:25:33,791 --> 02:25:34,759 COMMENTS AND THE THIRD IS 4293 02:25:34,826 --> 02:25:35,660 PERHAPS THE BROADER RESEARCH 4294 02:25:35,726 --> 02:25:36,761 COMMUNITY WHO MIGHT BE LOOKING 4295 02:25:36,828 --> 02:25:41,132 FOR OPINIONS AND GUIDANCE. 4296 02:25:41,199 --> 02:25:42,733 AND IN THINKING INTO THE FUTURE, 4297 02:25:42,800 --> 02:25:44,001 I THINK IT'S IMPORTANT FOR NIMH 4298 02:25:44,068 --> 02:25:45,870 TO KNOW IF THE DOCUMENT HAS DONE 4299 02:25:45,937 --> 02:25:49,140 ITS JOB. 4300 02:25:49,207 --> 02:25:50,675 SO FOR PROGRAM OFFICERS DURING 4301 02:25:50,741 --> 02:25:51,742 OUR DISCUSSION, WE TALKED ABOUT 4302 02:25:51,809 --> 02:25:53,511 AN ALTERNATE REPORT STRUCTURE 4303 02:25:53,578 --> 02:25:55,646 WHERE WE WOULD USE CASE STUDIES 4304 02:25:55,713 --> 02:25:56,614 TO DEMONSTRATE PARTICULAR TYPES 4305 02:25:56,681 --> 02:26:00,017 OF ISSUES THAT PROGRAM OFFICERS 4306 02:26:00,084 --> 02:26:01,419 ENCOUNTER, AND WE ULTIMATELY 4307 02:26:01,486 --> 02:26:04,222 PRODUCED A DOCUMENT THAT HAD 4308 02:26:04,288 --> 02:26:05,857 PRETTY GENERAL ALTHOUGH 4309 02:26:05,923 --> 02:26:07,592 SOMETIMES PERHAPS MAYBE 4310 02:26:07,658 --> 02:26:10,294 CONTROVERSIAL RATIONALS OR 4311 02:26:10,361 --> 02:26:11,095 RECOMMENDATION, SO ONE QUESTION 4312 02:26:11,162 --> 02:26:12,597 I THINK TO ASK GOING FORWARD IS 4313 02:26:12,663 --> 02:26:15,733 HAS THIS DOCUMENT ACTUALLY AID 4314 02:26:15,800 --> 02:26:18,002 AIDED, IF WE ADOPT IT, THE NIMH 4315 02:26:18,069 --> 02:26:20,605 PROGRAM OFFICERS IN EVALUATING 4316 02:26:20,671 --> 02:26:22,507 GRANTS, AND IF NOT, IS THERE 4317 02:26:22,573 --> 02:26:23,207 FOLLOW-UP WORK THAT NEEDS TO BE 4318 02:26:23,274 --> 02:26:24,642 DONE TO ADDRESS SPECIFIC 4319 02:26:24,709 --> 02:26:26,811 QUESTIONS TO MAKE IT MORE -- OR 4320 02:26:26,878 --> 02:26:32,483 TO ADD ON TO IT LIKE AFTER THE 4321 02:26:32,550 --> 02:26:32,817 CONSTITUTION. 4322 02:26:32,884 --> 02:26:35,453 FOR PEOPLE APPLYING FOR GRANTS, 4323 02:26:35,520 --> 02:26:36,654 HOW WILL THEY FIND THIS 4324 02:26:36,721 --> 02:26:38,456 INFORMATION, WILL IT BE PUT INTO 4325 02:26:38,523 --> 02:26:41,492 FUNDING ANNOUNCEMENTS, AND IT 4326 02:26:41,559 --> 02:26:43,361 REALLY GOT ME THINKING ABOUT THE 4327 02:26:43,427 --> 02:26:44,328 TENSION WHEN YOU WRITE A GRANT 4328 02:26:44,395 --> 02:26:45,596 BETWEEN THE AMOUNT OF SPACE IT 4329 02:26:45,663 --> 02:26:48,466 WOULD TAKE TO FULFILL ALL THE 4330 02:26:48,533 --> 02:26:50,601 RECOMMENDATIONS AND TO DESCRIBE 4331 02:26:50,668 --> 02:26:52,170 THE BIOLOGY AND THE RATIONALE 4332 02:26:52,236 --> 02:26:52,937 BEHIND THE EXPERIMENTS THAT YOU 4333 02:26:53,004 --> 02:26:55,306 WERE DOING, SO IT'S A LITTLE BIT 4334 02:26:55,373 --> 02:26:58,142 OF AN ASPIRATIONAL GOAL, AND HOW 4335 02:26:58,209 --> 02:27:00,244 COULD NIMH TRACK HOW THIS 4336 02:27:00,311 --> 02:27:01,279 DOCUMENT IS BEING USED, HOW 4337 02:27:01,345 --> 02:27:04,682 OFTEN IT'S BEING ACCESSED, AND 4338 02:27:04,749 --> 02:27:06,751 IS IT POSSIBLE TO GATHER 4339 02:27:06,817 --> 02:27:07,885 FEEDBACK AND PUBLIC COMMENTARY 4340 02:27:07,952 --> 02:27:09,387 THAT MIGHT ACTUALLY PROVIDE AN 4341 02:27:09,453 --> 02:27:11,088 INTERESTING DIALOGUE GOING 4342 02:27:11,155 --> 02:27:14,492 FORWARD ON THESE ISSUES. 4343 02:27:14,559 --> 02:27:16,127 >> THANK YOU FOR THOSE 4344 02:27:16,194 --> 02:27:19,697 CHALLENGES, AND I THINK -- FOR 4345 02:27:19,764 --> 02:27:20,898 ELUCIDATING THOSE CHALLENGES, I 4346 02:27:20,965 --> 02:27:22,433 SHOULD SAY, AND I THINK WE CAN 4347 02:27:22,500 --> 02:27:24,168 DO THAT, WE CAN TRACK AND WE CAN 4348 02:27:24,235 --> 02:27:25,570 EXPLAIN AND WE CAN FOLLOW UP. 4349 02:27:25,636 --> 02:27:26,971 FIRST AND FOREMOST SO THAT 4350 02:27:27,038 --> 02:27:28,439 EVERYONE UNDERSTANDS WHAT 4351 02:27:28,506 --> 02:27:29,674 HAPPENS AFTER COUNCIL WORK GROUP 4352 02:27:29,740 --> 02:27:32,510 REPORT, ONCE IT'S ADOPTED IN 4353 02:27:32,577 --> 02:27:33,578 FINAL FORM FROM THIS GROUP, IT 4354 02:27:33,644 --> 02:27:34,879 GETS PUT ON OUR WEBSITE FOR ALL 4355 02:27:34,946 --> 02:27:35,846 TO SEE. 4356 02:27:35,913 --> 02:27:38,416 SO AT THE VERY LEAST, IT IS A 4357 02:27:38,482 --> 02:27:38,916 PUBLIC-FACING DOCUMENT. 4358 02:27:38,983 --> 02:27:40,518 SECOND, IT IS OUR INTENTION TO 4359 02:27:40,585 --> 02:27:41,953 REVIEW THE RECOMMENDATIONS AND 4360 02:27:42,019 --> 02:27:44,889 SEE IF THEY MERIT ANY PARTICULAR 4361 02:27:44,956 --> 02:27:45,690 POLICY CHANGES. 4362 02:27:45,756 --> 02:27:47,792 OF COURSE MOST OF YOU KNOW IN 4363 02:27:47,858 --> 02:27:50,194 THE WAKE OF THE COUNCIL WORK 4364 02:27:50,261 --> 02:27:51,862 GROUP REPORT, FOR EXAMPLE, ON 4365 02:27:51,929 --> 02:27:54,532 GENOMICS THAT WAS DONE ABOUT 4366 02:27:54,599 --> 02:27:56,167 EIGHT OR NINE YEARS A WE CREATED 4367 02:27:56,234 --> 02:27:59,804 A SERIES OF DOCUMENTS AND IT 4368 02:27:59,870 --> 02:28:02,240 AFFECTED OUR GRANT POLICY TO A 4369 02:28:02,306 --> 02:28:03,241 PRETTY SIGNIFICANT DEGREE AND 4370 02:28:03,307 --> 02:28:04,442 WE'LL BE LOOKING THROUGH THESE 4371 02:28:04,508 --> 02:28:07,044 RECOMMENDATIONS TO SEE WHETHER 4372 02:28:07,111 --> 02:28:08,012 THERE ARE THINGS WE NEED TO 4373 02:28:08,079 --> 02:28:09,647 ADOPT IN A FORMAL WAY AND LET 4374 02:28:09,714 --> 02:28:10,314 PEOPLE KNOW. 4375 02:28:10,381 --> 02:28:11,482 BUT I LOVE THE IDEA IN 4376 02:28:11,549 --> 02:28:12,783 PARTICULAR OF TRACKING AND 4377 02:28:12,850 --> 02:28:14,986 BRINGING BACK TO THIS BODY WHAT 4378 02:28:15,052 --> 02:28:18,022 WE SEE AS A CONSEQUENCE OF THE 4379 02:28:18,089 --> 02:28:18,289 DOCUMENT. 4380 02:28:18,356 --> 02:28:21,125 >> I HAD ONE MORE ACTUALLY, I 4381 02:28:21,192 --> 02:28:22,593 LOST THE END OF MY PAGE BUT IT'S 4382 02:28:22,660 --> 02:28:23,995 EXACTLY WHAT YOU SAID. 4383 02:28:24,061 --> 02:28:27,632 SO IN HAVING THESE DISCUSSIONS, 4384 02:28:27,698 --> 02:28:29,233 THE THING THAT KEPT GOING 4385 02:28:29,300 --> 02:28:31,068 THROUGH MY MIND IS, WHAT IF I 4386 02:28:31,135 --> 02:28:32,937 HAD A TRACKER ON ALL THE 4387 02:28:33,004 --> 02:28:36,207 ANALYSES THAT MY GROUP RUNS, AND 4388 02:28:36,274 --> 02:28:38,276 HOW ACCOUNTING FOR ALL THE TESTS 4389 02:28:38,342 --> 02:28:41,779 WE'VE RUN WOULD ACTUALLY AFFECT 4390 02:28:41,846 --> 02:28:43,147 THE NUMBER OF RESULTS THAT WE 4391 02:28:43,214 --> 02:28:43,614 CALLED SIGNIFICANT. 4392 02:28:43,681 --> 02:28:46,217 I THINK THERE'S ACTUALLY AN 4393 02:28:46,284 --> 02:28:47,885 INTERESTING PERHAPS BODY OF 4394 02:28:47,952 --> 02:28:50,221 RESEARCH TO BE DONE OR AN RFA ON 4395 02:28:50,288 --> 02:28:53,190 GRANTS THAT REALLY DELVE INTO 4396 02:28:53,257 --> 02:28:54,592 DEALING WITH THIS ON A VERY 4397 02:28:54,659 --> 02:28:57,295 PRACTICAL ISSUE. 4398 02:28:57,361 --> 02:28:58,095 >> OTHER QUESTIONS OR COMMENTS 4399 02:28:58,162 --> 02:29:04,969 FROM MEMBERS OF COUNCIL? 4400 02:29:05,036 --> 02:29:07,638 WHILE YOU'RE FORMULATING THAT, I 4401 02:29:07,705 --> 02:29:08,406 ACTUALLY HAVE A FEW I WOULD LIKE 4402 02:29:08,472 --> 02:29:13,010 TO ASK MYSELF. 4403 02:29:13,077 --> 02:29:15,613 FIRST, YOU MENTIONED IN YOUR 4404 02:29:15,680 --> 02:29:16,247 PRESENTATION, DAMIEN, AND MAYBE 4405 02:29:16,314 --> 02:29:18,983 SOMEONE ELSE COULD ANSWER IF NOT 4406 02:29:19,050 --> 02:29:20,318 YOU, ABOUT -- PARTICULARLY ABOUT 4407 02:29:20,384 --> 02:29:21,185 PILOT STUDIES. 4408 02:29:21,252 --> 02:29:23,754 I GUESS I WOULD LIKE TO ASK THE 4409 02:29:23,821 --> 02:29:26,123 QUESTION, IF A PILOT STUDY IS 4410 02:29:26,190 --> 02:29:28,292 NOT AIMED TO FIND A 4411 02:29:28,359 --> 02:29:28,826 STATISTICALLY SIGNIFICANT 4412 02:29:28,893 --> 02:29:29,493 RESULT, WHAT IS THE GOAL OF A 4413 02:29:29,560 --> 02:29:31,062 PILOT STUDY THAT THE GROUP WOULD 4414 02:29:31,128 --> 02:29:34,131 ENDORSE? 4415 02:29:34,198 --> 02:29:38,202 >> IT'S A GOOD QUESTION, I MEAN, 4416 02:29:38,269 --> 02:29:39,403 AND OF COURSE IT ALWAYS DEPENDS, 4417 02:29:39,470 --> 02:29:40,738 IT WOULDN'T NECESSARILY BE THAT 4418 02:29:40,805 --> 02:29:42,306 THERE WOULD BE NO CASES WHERE 4419 02:29:42,373 --> 02:29:43,941 YOU WOULD EXPECT A SIGNIFICANT 4420 02:29:44,008 --> 02:29:45,042 RESULT OF COURSE, BUT THINKING 4421 02:29:45,109 --> 02:29:47,645 ABOUT FEASIBILITY, LOOKING A AT 4422 02:29:47,712 --> 02:29:50,348 TRENDS, IN OTHER WORDS, WHAT DO 4423 02:29:50,414 --> 02:29:50,815 YOU VALUE. 4424 02:29:50,881 --> 02:29:52,450 IF YOU HAVE AN UNDERPOWERED 4425 02:29:52,516 --> 02:29:53,984 STUDY, YOU SEE A NOT SIGNIFICANT 4426 02:29:54,051 --> 02:29:55,019 RESULT IF THE TREND, THAT MEANS 4427 02:29:55,086 --> 02:29:56,887 YOU MIGHT BE RIGHT, RIGHT? 4428 02:29:56,954 --> 02:30:00,224 SO THAT WOULD BE -- BUT WE DON'T 4429 02:30:00,291 --> 02:30:02,526 TYPICALLY VALUE PILOT STUDIES 4430 02:30:02,593 --> 02:30:03,928 THAT DON'T HAVE THAT 4431 02:30:03,994 --> 02:30:04,929 SIGNIFICANCE TAG ON IT IN THE 4432 02:30:04,995 --> 02:30:06,297 SAME WAY, EVEN THOUGH YOU 4433 02:30:06,364 --> 02:30:07,932 PROBABLY SHOULD CONSIDER THEY'RE 4434 02:30:07,998 --> 02:30:08,265 UNDERPOWERED. 4435 02:30:08,332 --> 02:30:09,367 DO YOU SEE WHAT I MEAN? 4436 02:30:09,433 --> 02:30:10,868 SO IT'S A LITTLE BIT OF A SHIFT 4437 02:30:10,935 --> 02:30:12,970 OF HOW YOU'RE THINKING, I THINK. 4438 02:30:13,037 --> 02:30:16,674 >> SO OFTEN THE ROLE OF THE 4439 02:30:16,741 --> 02:30:18,209 PILOT STUDY IS TO DEMONSTRATE 4440 02:30:18,275 --> 02:30:20,010 THE TECHNOLOGICAL FEASIBILITY OF 4441 02:30:20,077 --> 02:30:24,148 WHAT'S PROPOSED, OR TO COMPARE 4442 02:30:24,215 --> 02:30:25,983 VARIOUS TECHNICAL APPROACHES AND 4443 02:30:26,050 --> 02:30:28,486 MAKE DECISIONS BETWEEN THEM. 4444 02:30:28,552 --> 02:30:30,254 I THINK WHAT THE GROUP IS 4445 02:30:30,321 --> 02:30:31,455 RECOMMENDING IS THAT YOU'VE GOT 4446 02:30:31,522 --> 02:30:34,725 A WINNER'S CURSE THING GOING ON 4447 02:30:34,792 --> 02:30:35,659 STATISTICALLY. 4448 02:30:35,726 --> 02:30:36,994 THE ONLY EFFECTS YOU CAN DETECT 4449 02:30:37,061 --> 02:30:38,729 IN A SAMPLE SIZE OF 50 4450 02:30:38,796 --> 02:30:39,997 INDIVIDUALS ARE THE REALLY, 4451 02:30:40,064 --> 02:30:41,399 REALLY HUGE ONES. 4452 02:30:41,465 --> 02:30:43,601 AND YOU CAN'T USE THAT TO SAY 4453 02:30:43,667 --> 02:30:44,835 LOOK, ALL THE EFFECTS ARE 4454 02:30:44,902 --> 02:30:46,303 REALLY, REALLY HUGE, SO WE HAVE 4455 02:30:46,370 --> 02:30:48,706 BASED OUR POWER CALCULATIONS ON 4456 02:30:48,773 --> 02:30:50,574 THE EXISTENCE OF GIGANTIC 4457 02:30:50,641 --> 02:30:51,342 EFFECTS. 4458 02:30:51,409 --> 02:30:53,711 >> THANK YOU. 4459 02:30:53,778 --> 02:30:55,813 RINAD. 4460 02:30:55,880 --> 02:30:57,948 >> THANK YOU FOR THIS VERY HARD 4461 02:30:58,015 --> 02:30:58,416 WORK. 4462 02:30:58,482 --> 02:31:00,384 WHEN I WAS READING THROUGH THE 4463 02:31:00,451 --> 02:31:01,752 REPORT, THE PIECE ABOUT THE 4464 02:31:01,819 --> 02:31:04,155 CLINICAL UTILITY WAS LESS CLEAR 4465 02:31:04,221 --> 02:31:06,457 TO ME, AND I WAS WONDERING IF 4466 02:31:06,524 --> 02:31:07,591 YOU ALL COULD SPEAK TO THAT A 4467 02:31:07,658 --> 02:31:08,058 LITTLE BIT. 4468 02:31:08,125 --> 02:31:10,127 I DON'T KNOW IF THAT MEANS CLING 4469 02:31:10,194 --> 02:31:13,597 SOME KIND OF DESCRIPTION OF 4470 02:31:13,664 --> 02:31:15,332 ENGAGEMENT OF COMMUNITY OR 4471 02:31:15,399 --> 02:31:17,301 TRANSLATIONAL SCIENCE BENEFIT OR 4472 02:31:17,368 --> 02:31:18,702 ABILITY TO CENTER EQUITY WITH 4473 02:31:18,769 --> 02:31:20,471 THE DATA OR IMPLEMENT ABILITY OF 4474 02:31:20,538 --> 02:31:22,573 WHAT'S FOUND FROM THE HIGH 4475 02:31:22,640 --> 02:31:23,908 DIMENSIONAL DATA, AND I MIGHT BE 4476 02:31:23,974 --> 02:31:25,476 COMPLETELY OFF AND THAT'S OKAY, 4477 02:31:25,543 --> 02:31:27,945 BECAUSE I DON'T THINK I USE HIGH 4478 02:31:28,012 --> 02:31:29,246 DIMENSIONAL DATA, BUT I'M 4479 02:31:29,313 --> 02:31:30,247 CURIOUS IF YOU COULD SPEAK A 4480 02:31:30,314 --> 02:31:33,717 LITTLE BIT MORE ABOUT THAT 4481 02:31:33,784 --> 02:31:34,885 FOURTH CHARGE, WHICH SEEMED TO 4482 02:31:34,952 --> 02:31:44,094 BE ABOUT THE CLINICAL UTILITY. 4483 02:31:44,161 --> 02:31:46,096 YOU WANT 4484 02:31:46,163 --> 02:31:48,666 >> YOU WANT TO TAKE THAT, LAURA? 4485 02:31:48,732 --> 02:31:50,868 >> MY ANSWER FOR YOU IS KIND OF 4486 02:31:50,935 --> 02:31:52,903 SQUISHY. 4487 02:31:52,970 --> 02:31:57,374 A MAJORITY OF THE WORKING GROUP 4488 02:31:57,441 --> 02:31:59,877 WAS MORE ON THE BASIC SCIENCE 4489 02:31:59,944 --> 02:32:02,913 KIND OF SIDE, THOUGH WE DID HAVE 4490 02:32:02,980 --> 02:32:05,082 A FEW REPRESENTATIVES IN THE 4491 02:32:05,149 --> 02:32:07,585 CLINICAL SPACE WHO BROUGHT US 4492 02:32:07,651 --> 02:32:09,787 BACK TO THAT QUESTION. 4493 02:32:09,854 --> 02:32:13,023 AND I THINK SOME OF THE 4494 02:32:13,090 --> 02:32:15,326 FUNDAMENTAL THEMES THAT CAME UP 4495 02:32:15,392 --> 02:32:22,233 WERE RECOGNIZING THAT THESE ARE 4496 02:32:22,299 --> 02:32:23,334 DIFFERENT THOUGHT SPACES AND 4497 02:32:23,400 --> 02:32:26,003 THAT WHAT CONSTITUTES A 4498 02:32:26,070 --> 02:32:26,604 SIGNIFICANT EFFECT DIFFERENT 4499 02:32:26,670 --> 02:32:28,405 WHEN YOU ARE TRYING TO GAIN 4500 02:32:28,472 --> 02:32:31,041 INSIGHT REGARDING MECHANISM THAN 4501 02:32:31,108 --> 02:32:37,047 WHEN YOU ARE TRYING TO ASSESS 4502 02:32:37,114 --> 02:32:38,115 WHETHER AN INTERVENTION HAS 4503 02:32:38,182 --> 02:32:40,951 HELPED OR NOT. 4504 02:32:41,018 --> 02:32:44,255 SO SOME OF THIS THINKING WENT 4505 02:32:44,321 --> 02:32:46,257 TOWARD WHAT'S A SIGNIFICANT 4506 02:32:46,323 --> 02:32:47,057 EFFECT SIZE? 4507 02:32:47,124 --> 02:32:51,428 AND THE IDEA THAT THE ISSUE OF 4508 02:32:51,495 --> 02:32:55,566 POWER IS SOMEWHAT DIFFERENT IN 4509 02:32:55,633 --> 02:32:57,167 THE CLINICAL SPACE BECAUSE OFTEN 4510 02:32:57,234 --> 02:32:59,870 WE ARE NOT INTERESTED IN WHETHER 4511 02:32:59,937 --> 02:33:01,038 IT'S DIFFERENT FROM ZERO, BUT 4512 02:33:01,105 --> 02:33:03,040 WHETHER IT IS A CLINICALLY 4513 02:33:03,107 --> 02:33:03,440 MEANINGFUL EFFECT. 4514 02:33:03,507 --> 02:33:09,280 >> YEAH. 4515 02:33:09,346 --> 02:33:10,514 LAURA IT'S IN PART SQUISHY 4516 02:33:10,581 --> 02:33:11,916 BECAUSE WE KIND OF FELL OFF A 4517 02:33:11,982 --> 02:33:13,517 CLIFF AT THE END OF THIS, LIKE 4518 02:33:13,584 --> 02:33:14,952 GETTING THROUGH ALL THE STUFF TO 4519 02:33:15,019 --> 02:33:17,888 BE HONEST, BUT WHAT I CAN SAY ON 4520 02:33:17,955 --> 02:33:19,523 THIS PARTICULAR TOPIC, WHAT WE 4521 02:33:19,590 --> 02:33:23,994 TRIED TO MAKE CLEAR IS THAT NOT 4522 02:33:24,061 --> 02:33:25,462 ALL USEFUL SCIENCE HAS TO HAVE 4523 02:33:25,529 --> 02:33:27,231 SOME KIND OF CLINICAL UTILITY, 4524 02:33:27,298 --> 02:33:27,631 LIKE TODAY. 4525 02:33:27,698 --> 02:33:28,265 THAT WAS ONE. 4526 02:33:28,332 --> 02:33:31,835 AND THEN NUMBER TWO IS, JUST 4527 02:33:31,902 --> 02:33:33,470 SAYING SOMETHING HAS CLINICAL 4528 02:33:33,537 --> 02:33:34,805 UTILITY IS MAYBE NOT ENOUGH IN 4529 02:33:34,872 --> 02:33:37,975 THESE AWARDS, BUT THAT IF IT 4530 02:33:38,042 --> 02:33:39,009 REALLY IS SOMETHING THAT'S GOING 4531 02:33:39,076 --> 02:33:40,444 TO BE CLINICALLY -- HAVE 4532 02:33:40,511 --> 02:33:41,645 CLINICAL UTILITY, HOW DO YOU 4533 02:33:41,712 --> 02:33:43,514 PLAY THAT FORWARD INTO HOW IT 4534 02:33:43,581 --> 02:33:45,115 WILL ACTUALLY BECOME CLINICALLY 4535 02:33:45,182 --> 02:33:45,683 USEFUL. 4536 02:33:45,749 --> 02:33:47,318 THAT REQUIRES A LITTLE BIT 4537 02:33:47,384 --> 02:33:49,386 DEEPER THOUGHT THAN WE TYPICALLY 4538 02:33:49,453 --> 02:33:50,888 ARE -- HOW WE TYPICALLY THINK 4539 02:33:50,955 --> 02:33:53,657 OF, YOU KNOW, IT'S NOT A PIE IN 4540 02:33:53,724 --> 02:33:55,059 THE SKY BUT THESE ARE PLAYING 4541 02:33:55,125 --> 02:33:57,628 FORWARD A LITTLE BIT WITH -- I'M 4542 02:33:57,695 --> 02:34:00,130 JUST GOING TO SAY SOMETHING KIND 4543 02:34:00,197 --> 02:34:01,565 OF OUT THERE SO PEOPLE GET IT, 4544 02:34:01,632 --> 02:34:04,802 BUT THERE'S PAYORS INVOLVED, 4545 02:34:04,868 --> 02:34:06,136 THERE'S -- BECAUSE IT 4546 02:34:06,203 --> 02:34:07,037 COMMERCIALIZES, IS THERE ALL 4547 02:34:07,104 --> 02:34:08,439 THESE DIFFERENT ASPECTS OF LIKE 4548 02:34:08,505 --> 02:34:10,240 MAKING SOMETHING CLINICALLY 4549 02:34:10,307 --> 02:34:11,709 USEFUL. 4550 02:34:11,775 --> 02:34:13,010 SO THAT SOME OF THOSE 4551 02:34:13,077 --> 02:34:15,946 DESCRIPTIONS OF HOW WE MAY WANT 4552 02:34:16,013 --> 02:34:18,349 TO VALUE MORE DETAIL ON HOW CAN 4553 02:34:18,415 --> 02:34:20,417 WE GET TO THAT CLINICAL UTILITY 4554 02:34:20,484 --> 02:34:22,386 THAN JUST SAYING IT IS TO BE SO 4555 02:34:22,453 --> 02:34:24,355 BECAUSE IT SOUNDS LIKE IT COULD 4556 02:34:24,421 --> 02:34:24,788 BE. 4557 02:34:24,855 --> 02:34:26,757 SO SOME OF THOSE ASPECTS, NOT 4558 02:34:26,824 --> 02:34:28,025 ALL THAT STUFF MADE TO THE END 4559 02:34:28,092 --> 02:34:29,660 OF THE DOCUMENT BUT LIKE I SAID, 4560 02:34:29,727 --> 02:34:31,862 FOLKS WERE GETTING TIRED AND WE 4561 02:34:31,929 --> 02:34:33,597 WERE -- WE DIDN'T GET INTO 4562 02:34:33,664 --> 02:34:35,232 THE -- TOO MUCH INTO THE WEEDS 4563 02:34:35,299 --> 02:34:36,333 ON THAT AT THE END OF THE DAY. 4564 02:34:36,400 --> 02:34:40,471 >> ANOTHER THEME THAT CAME UP 4565 02:34:40,537 --> 02:34:42,973 WAS IN THE CLINICAL UTILITY 4566 02:34:43,040 --> 02:34:44,475 SPACE, THE VALUE OF SOMETHING 4567 02:34:44,541 --> 02:34:53,550 THAT IS PURELY A PREDICT TER A D 4568 02:34:53,617 --> 02:34:54,284 OUR CLINICAL COLLEAGUES TELLING 4569 02:34:54,351 --> 02:34:57,354 US THAT THE ROLE OF HYPOTHESES 4570 02:34:57,421 --> 02:34:59,323 WERE SOMEWHAT DIFFERENT WHEN 4571 02:34:59,390 --> 02:35:02,159 WHAT YOU CARE ABOUT IS 4572 02:35:02,226 --> 02:35:04,228 BUILDING -- USING THE BIG DATA 4573 02:35:04,294 --> 02:35:06,730 TO BUILD A PREDICTOR THROUGH 4574 02:35:06,797 --> 02:35:08,599 YOUR MACHINE LEARNING ALGORITHM, 4575 02:35:08,666 --> 02:35:10,968 HAVING A HYPOTHESIS ABOUT WHAT 4576 02:35:11,035 --> 02:35:12,936 THE SPECIFIC MECHANISMS WERE 4577 02:35:13,003 --> 02:35:14,238 THAT CONNECT BETWEEN THE BIG 4578 02:35:14,304 --> 02:35:18,175 DATA AND TH THE OUTCOME WAS REAY 4579 02:35:18,242 --> 02:35:19,777 NOT IMPORTANT TO OUR CLINICAL 4580 02:35:19,843 --> 02:35:21,011 COLLEAGUES NECESSARILY AS 4581 02:35:21,078 --> 02:35:22,613 BUILDING THE PREDICTOR. 4582 02:35:22,680 --> 02:35:24,481 SO THINKING ABOUT THOSE KINDS OF 4583 02:35:24,548 --> 02:35:26,784 ISSUES AS TO HOW WE MIGHT 4584 02:35:26,850 --> 02:35:30,054 DIFFERENTLY PRIORITIZE THE ROLE 4585 02:35:30,120 --> 02:35:31,889 OF HYPOTHESIS AND STUDY DESIGN 4586 02:35:31,955 --> 02:35:36,360 WHEN WE WERE GOING TOWARD THOSE 4587 02:35:36,427 --> 02:35:36,927 DIFFERENT END POINTS. 4588 02:35:36,994 --> 02:35:38,095 >> THANK YOU. 4589 02:35:38,162 --> 02:35:42,733 ANGUS. 4590 02:35:42,800 --> 02:35:44,101 >> THANK YOU, AND THANKS TO THE 4591 02:35:44,168 --> 02:35:44,968 WORK GROUP FOR ALL OF THE 4592 02:35:45,035 --> 02:35:49,006 EFFORTS THAT YOU'VE PUT IN. 4593 02:35:49,073 --> 02:35:50,307 SORT OF PICKING UP ON THE LAST 4594 02:35:50,374 --> 02:35:52,810 TWO QUESTIONS IN THIS KIND OF 4595 02:35:52,876 --> 02:35:55,446 CATCH-22 AROUND THE POWER 4596 02:35:55,512 --> 02:36:01,118 ANALYSIS, IF YOU CAN'T SORT OF 4597 02:36:01,185 --> 02:36:03,487 RELY ON THE DATA OR EVEN THE 4598 02:36:03,554 --> 02:36:06,557 PUBLISHED DATA THAT ARE OUT 4599 02:36:06,623 --> 02:36:10,494 THERE AS WAS MENTIONED, WAS 4600 02:36:10,561 --> 02:36:11,995 THERE ANY DISCUSSION IN THE WORK 4601 02:36:12,062 --> 02:36:14,264 GROUP AROUND OTHER WAYS TO 4602 02:36:14,331 --> 02:36:17,434 THERNGTHINKOF THE PROBLEM, LIKEA 4603 02:36:17,501 --> 02:36:17,901 SENSITIVITY ANALYSIS? 4604 02:36:17,968 --> 02:36:20,070 ONE OF THE THINGS WE'RE SORT OF 4605 02:36:20,137 --> 02:36:21,271 MINDFUL AROUND HERE, WE WERE 4606 02:36:21,338 --> 02:36:24,742 JUST TALKING ABOUT BUDGET, SO -- 4607 02:36:24,808 --> 02:36:26,110 THERE ARE THESE CONSTRAINTS ON 4608 02:36:26,176 --> 02:36:28,445 THE KIND OF SCALE THAT PEOPLE 4609 02:36:28,512 --> 02:36:31,381 ARE ABLE TO COLLECT DATA AT. 4610 02:36:31,448 --> 02:36:33,550 A SENSITIVITY ANALYSIS IS OKAY, 4611 02:36:33,617 --> 02:36:36,787 THIS IS WHAT WE ARE 4612 02:36:36,854 --> 02:36:38,589 REALISTICALLY ABLE TO DO, WE 4613 02:36:38,655 --> 02:36:39,890 THINK THAT WE'RE GOING TO BE 4614 02:36:39,957 --> 02:36:42,493 SENSITIVE TO EFFECT SIZES OF 4615 02:36:42,559 --> 02:36:45,996 THIS SCALE AND WE THINK THAT 4616 02:36:46,063 --> 02:36:47,564 THOSE ARE REASONABLE EFFECT 4617 02:36:47,631 --> 02:36:52,035 SIZES TO BE SENSITIVE TO. 4618 02:36:52,102 --> 02:36:55,506 AND I WAS WONDERING IF -- WHICH 4619 02:36:55,572 --> 02:36:58,475 IS SORT OF TAKING TWO ELEMENTS, 4620 02:36:58,542 --> 02:37:01,512 WHICH IS AS OPPOSED TO SAYING 4621 02:37:01,578 --> 02:37:03,380 HOW MANY PEOPLE DO I HAVE AND 4622 02:37:03,447 --> 02:37:04,448 SAYING THIS IS HOW MANY PEOPLE I 4623 02:37:04,515 --> 02:37:05,916 HAVE, THIS IS THE ANALYSIS I'M 4624 02:37:05,983 --> 02:37:09,119 GOING TO BE USING, I'M GOING TO 4625 02:37:09,186 --> 02:37:11,722 BE -- I HAVE THIS MUCH POWER TO 4626 02:37:11,789 --> 02:37:12,489 BE SINCETIVE TO SOMETHING THAT'S 4627 02:37:12,556 --> 02:37:16,226 THIS SMALL. 4628 02:37:16,293 --> 02:37:20,597 AND THAT IS A WAY OF BACKING 4629 02:37:20,664 --> 02:37:22,666 INTO A POWER ANALYSIS. 4630 02:37:22,733 --> 02:37:26,603 AND PERHAPS ALLOWS ONE TO SAY, 4631 02:37:26,670 --> 02:37:28,138 WELL, THAT EFFECT SIZE IS MUCH 4632 02:37:28,205 --> 02:37:31,341 SMALLER OR NO SMALLER OR -- THAN 4633 02:37:31,408 --> 02:37:32,709 WHAT WAS PREVIOUSLY OBSERVED IN 4634 02:37:32,776 --> 02:37:35,546 THE DATA. 4635 02:37:35,612 --> 02:37:38,282 YOUR EXPRESSIONS, SORT OF 4636 02:37:38,348 --> 02:37:41,418 SUGGEST TO ME, NO, WE DID 4637 02:37:41,485 --> 02:37:43,520 SUGGEST SENSITIVITY ANALYSES OR 4638 02:37:43,587 --> 02:37:45,022 YOU'RE JUST WAITING FOR ME TO 4639 02:37:45,088 --> 02:37:47,224 STOP TALKING. 4640 02:37:47,291 --> 02:37:47,491 [LAUGHTER] 4641 02:37:47,558 --> 02:37:49,293 >> WE DID NOT -- WE DIDN'T 4642 02:37:49,359 --> 02:37:52,696 DISCUSS SENSITIVITY ANALYSES PER 4643 02:37:52,763 --> 02:37:53,397 SE. 4644 02:37:53,463 --> 02:37:55,632 BUT AGAIN, LIKE WHAT WE'RE -- 4645 02:37:55,699 --> 02:37:57,467 WHAT WAS PROPOSED HERE IS NOT 4646 02:37:57,534 --> 02:37:58,335 EXHAUSTIVE BY ANY MEANS. 4647 02:37:58,402 --> 02:37:59,336 IT DOESN'T MEAN THAT THAT 4648 02:37:59,403 --> 02:38:06,743 SHOULDN'T BE CONSIDERED. 4649 02:38:06,810 --> 02:38:09,580 I THINK THE MAIN POINT -- THE 4650 02:38:09,646 --> 02:38:10,547 RECOMMENDATION WE'RE TRYING TO 4651 02:38:10,614 --> 02:38:11,748 SPLIT THE NEEDLE WHERE WE'RE 4652 02:38:11,815 --> 02:38:12,916 NOT -- I DON'T THINK THERE WAS A 4653 02:38:12,983 --> 02:38:13,617 RECOMMENDATION THAT YOU SHOULD 4654 02:38:13,684 --> 02:38:17,321 NOT USE LITERATURE AT ALL. 4655 02:38:17,387 --> 02:38:19,690 BUT OFTENTIMES, YOU KNOW, IT'S 4656 02:38:19,756 --> 02:38:23,327 USING -- IF IT AVAILABLE, WELL 4657 02:38:23,393 --> 02:38:24,494 HIGHER POWERED STUDIES OR AT 4658 02:38:24,561 --> 02:38:25,729 LEAST THE PARAMETERS AROUND 4659 02:38:25,796 --> 02:38:27,097 THOSE HIGH POWERED STUDIES TO 4660 02:38:27,164 --> 02:38:28,131 HELP MAKE REASONABLE ESTIMATES 4661 02:38:28,198 --> 02:38:29,833 OF WHAT YOU SHOULD EXPECT FOR A 4662 02:38:29,900 --> 02:38:31,802 DIFFERENT EXPERIMENT. 4663 02:38:31,869 --> 02:38:32,970 I'D HAVE TO THINK THROUGH A LOT 4664 02:38:33,036 --> 02:38:35,172 MORE ABOUT LIKE THE SENSITIVITY 4665 02:38:35,239 --> 02:38:38,775 ANALYSIS ANGLE, ANGUS. 4666 02:38:38,842 --> 02:38:43,580 BUT I WENT R WOULDN'T RULE IT O. 4667 02:38:43,647 --> 02:38:44,681 I'D JUST HAVE TO THINK THROUGH 4668 02:38:44,748 --> 02:38:45,816 IT A ILL WILL BIT MORE. 4669 02:38:45,883 --> 02:38:46,049 >> TED. 4670 02:38:46,116 --> 02:38:48,485 >> CAN I RESPOND TO THAT COMMENT 4671 02:38:48,552 --> 02:38:48,685 ALSO? 4672 02:38:48,752 --> 02:38:49,486 >> SURE, GO AHEAD. 4673 02:38:49,553 --> 02:38:50,888 >> I ACTUALLY THINK THAT 4674 02:38:50,954 --> 02:38:52,256 INHERENT IN OUR DISCUSSION OF 4675 02:38:52,322 --> 02:38:54,691 THE POWER ANALYSES AND IN 4676 02:38:54,758 --> 02:38:58,095 WRITING A GRANT, RIGHT, BECAUSE 4677 02:38:58,161 --> 02:39:01,698 YOU'RE STRUGGLING WITH ENOUGH 4678 02:39:01,765 --> 02:39:04,468 SAMPLES OFTEN TO MATCH WHATEVER 4679 02:39:04,534 --> 02:39:05,969 EFFECT YOU HAVE THAT YOU ARE IN 4680 02:39:06,036 --> 02:39:08,605 ESSENCE DOING THAT, RIGHT, AND 4681 02:39:08,672 --> 02:39:10,741 IF THERE'S A PLACE WHERE WE 4682 02:39:10,807 --> 02:39:14,678 SUGGEST SIMULATIONS, SO I THINK 4683 02:39:14,745 --> 02:39:16,213 THAT -- I DON'T THINK IT'S SO 4684 02:39:16,280 --> 02:39:19,716 FAR AWAY FROM WHAT WE HAVE IN 4685 02:39:19,783 --> 02:39:21,985 HERE IN TERMS OF HOW YOU GO 4686 02:39:22,052 --> 02:39:23,754 ABOUT THAT AND MAYBE THERE CAN 4687 02:39:23,820 --> 02:39:26,456 BE LANGUAGE THAT WAS EXPLICIT 4688 02:39:26,523 --> 02:39:27,891 BUT I THINK IT WOULD FIT WITHIN 4689 02:39:27,958 --> 02:39:29,860 A COUPLE SENTENCES OF WHAT WE 4690 02:39:29,927 --> 02:39:31,461 HAVE IF WE PUT IT IN. 4691 02:39:31,528 --> 02:39:34,264 >> TED. 4692 02:39:34,331 --> 02:39:36,433 >> I WANTED TO MAKE A COMMENT 4693 02:39:36,500 --> 02:39:38,168 ABOUT THE REPORT REALLY FOR NIMH 4694 02:39:38,235 --> 02:39:41,972 STAFF AND FOR PROGRAM. 4695 02:39:42,039 --> 02:39:42,739 YOU THINK ABOUT THIS LOOKING AT 4696 02:39:42,806 --> 02:39:44,274 IT AND THINK OKAY FOR AN 4697 02:39:44,341 --> 02:39:45,475 INVESTIGATOR, WHAT KIND OF GRANT 4698 02:39:45,542 --> 02:39:48,078 AM I GOING TO WRITE, PROGRAM 4699 02:39:48,145 --> 02:39:49,947 OFFICER, WHAT SORT OF GRANT AM 4700 02:39:50,013 --> 02:39:50,847 YOU GOING TO FUND. 4701 02:39:50,914 --> 02:39:52,616 BUT THE OTHER THING TO REALIZE 4702 02:39:52,683 --> 02:39:53,951 AS YOU READ THROUGH THIS 4703 02:39:54,017 --> 02:39:54,584 DOCUMENT, PARTICULAR A LINEAR 4704 02:39:54,651 --> 02:39:56,053 THE END OF IT, IS THAT THERE'S 4705 02:39:56,119 --> 02:39:59,990 AN ASPECT OF THIS DOCUMENT THAT 4706 02:40:00,057 --> 02:40:03,126 SHAKES SCIENCE UP A LITTLE BIT. 4707 02:40:03,193 --> 02:40:05,562 THAT TALKS ABOUT DATA 4708 02:40:05,629 --> 02:40:07,164 AVAILABILITY, TALKS ABOUT 4709 02:40:07,230 --> 02:40:07,931 PREREGISTRATION, TALKS ABOUT 4710 02:40:07,998 --> 02:40:08,932 PREPRINTS, TALKS ABOUT HOW TO 4711 02:40:08,999 --> 02:40:10,567 THINK ABOUT YOUNG INVESTIGATORS 4712 02:40:10,634 --> 02:40:13,603 WHO ARE 252ND ON AN AUTHOR LIST 4713 02:40:13,670 --> 02:40:14,037 OF 290. 4714 02:40:14,104 --> 02:40:15,238 AND ALSO TALKS ABOUT RESOURCES 4715 02:40:15,305 --> 02:40:18,642 TO BE ABLE TO MAKE DATA 4716 02:40:18,709 --> 02:40:19,977 AVAILABLE, TO BE ABLE TO MAKE 4717 02:40:20,043 --> 02:40:20,644 CODE AVAILABLE. 4718 02:40:20,711 --> 02:40:21,611 FOR EXAMPLE, THERE'S BEEN A LOT 4719 02:40:21,678 --> 02:40:25,649 OF INVESTMENT IN WORK OF SPATIAL 4720 02:40:25,716 --> 02:40:27,718 TRANSCRIPTOMICS, BUT HOW DO YOU 4721 02:40:27,784 --> 02:40:29,987 ACTUALLY SHARE SPATIAL 4722 02:40:30,053 --> 02:40:31,321 TRANSCRIPTOMICS DATA? 4723 02:40:31,388 --> 02:40:32,389 THERE'S SOME EXAMPLES PEOPLE 4724 02:40:32,456 --> 02:40:35,759 HAVE DONE, BUT TO COMBINE THE 4725 02:40:35,826 --> 02:40:37,294 SPATIAL INFORMATION AND DO THAT 4726 02:40:37,361 --> 02:40:38,829 AKROT THE BRAIN, IT'S BACK TO 4727 02:40:38,895 --> 02:40:40,597 THE PROBLEM, NOW IT'S BEEN 4728 02:40:40,664 --> 02:40:43,400 SOLVED WITH CONSORTIUMS LIKE 4729 02:40:43,467 --> 02:40:44,167 ENIGMA. 4730 02:40:44,234 --> 02:40:45,602 THAT TAKES A LOT OF RESOURCES 4731 02:40:45,669 --> 02:40:46,903 FROM NIH TO INVEST IN SCIENCE 4732 02:40:46,970 --> 02:40:48,638 AND HOW WE DO SCIENCE. 4733 02:40:48,705 --> 02:40:50,374 SO I JUST WANT TO MAKE -- I JUST 4734 02:40:50,440 --> 02:40:53,877 WANT TO SORT OF POINT THAT OUT, 4735 02:40:53,944 --> 02:40:56,179 IF YOU REALLY LOOK AT THIS AND 4736 02:40:56,246 --> 02:40:59,649 KIND OF SQUINT A LITTLE BIT, YOU 4737 02:40:59,716 --> 02:41:01,151 REALIZE THERE'S SOME PUSHING AT 4738 02:41:01,218 --> 02:41:03,820 THE EDGES OF HOW WE DO SCIENCE. 4739 02:41:03,887 --> 02:41:06,056 YOU DESCRIBED THE BRAIN 4740 02:41:06,123 --> 02:41:06,656 INITIATIVE PROJECTS, SOMETHING 4741 02:41:06,723 --> 02:41:08,058 WE ALL HAVE TO THINK ABOUT 4742 02:41:08,125 --> 02:41:09,359 THAT'S A LITTLE BIT MORE FUZZIER 4743 02:41:09,426 --> 02:41:13,830 THAN JUST WHAT'S MY GRANT AND -- 4744 02:41:13,897 --> 02:41:14,064 FUNDING. 4745 02:41:14,131 --> 02:41:15,632 >> I THINK THAT'S A REALLY GOOD 4746 02:41:15,699 --> 02:41:17,134 POINT BUT I TEND TO BE CONCRETE 4747 02:41:17,200 --> 02:41:18,869 SO I'M GOING TO TRY TO GET CON 4748 02:41:18,935 --> 02:41:21,371 GREET FOR JUST A MOMENT. 4749 02:41:21,438 --> 02:41:23,607 DAMIEN, LAURA, ANYONE ELSE ON 4750 02:41:23,673 --> 02:41:28,045 THE COMMITTEE, ONE OF THE MOST 4751 02:41:28,111 --> 02:41:28,478 ACTUALLY CONCRETE 4752 02:41:28,545 --> 02:41:30,447 RECOMMENDATIONS FROM MY 4753 02:41:30,514 --> 02:41:33,383 PERSPECTIVE, YOU DIDN'T DETAIL 4754 02:41:33,450 --> 02:41:35,052 THE LANGUAGE OF IN YOUR 4755 02:41:35,118 --> 02:41:36,586 PRESENTATION BUT IT'S IN ONE OF 4756 02:41:36,653 --> 02:41:39,523 THE AREAS THAT YOU TALKED ABOUT, 4757 02:41:39,589 --> 02:41:42,225 IT HAS TO DO WITH VALIDATION AND 4758 02:41:42,292 --> 02:41:43,193 GENERALIZATION, AND I'M GOING TO 4759 02:41:43,260 --> 02:41:44,327 QUOTE FROM THE REPORT. 4760 02:41:44,394 --> 02:41:47,030 FOR EXAMPLE, PREDICTIVE STUDIES 4761 02:41:47,097 --> 02:41:48,365 SHOULD VALIDATE DEVELOPED 4762 02:41:48,432 --> 02:41:50,834 ALGORITHMS USING INDEPENDENT 4763 02:41:50,901 --> 02:41:52,502 DATA WITHOUT DEVELOPING ANY 4764 02:41:52,569 --> 02:41:55,539 ASPECTS OF THE MODEL IN ORDER TO 4765 02:41:55,605 --> 02:41:56,973 PREVENT ALGORITHMIC OVERFITTING. 4766 02:41:57,040 --> 02:41:58,742 SO TO MY MIND, THAT IS ACTUALLY 4767 02:41:58,809 --> 02:42:00,677 A VERY SPECIFIC AND PROVOCATIVE 4768 02:42:00,744 --> 02:42:02,312 SUGGESTION, WHICH IS NOT ADHERED 4769 02:42:02,379 --> 02:42:06,149 TO IN THE VAST MAJORITY OF THE 4770 02:42:06,216 --> 02:42:06,817 HIGH DIMENSIONAL DATA SET STUFF 4771 02:42:06,883 --> 02:42:07,717 THAT WE DO. 4772 02:42:07,784 --> 02:42:09,886 I WANT TO MAKE SURE I'M CORRECT, 4773 02:42:09,953 --> 02:42:12,722 THOUGH, BECAUSE THE LANGUAGE IS 4774 02:42:12,789 --> 02:42:13,957 A LITTLE BIT OBTUSE TO ME. 4775 02:42:14,024 --> 02:42:17,594 SO I THINK BHA YOU WHAT YOU'RE S 4776 02:42:17,661 --> 02:42:19,930 THAT WHEN YOU DESIGN A 4777 02:42:19,996 --> 02:42:21,231 PREDICTIVE MODEL, WHEN YOU BUILD 4778 02:42:21,298 --> 02:42:23,533 A PREDICTIVE MODEL, YOU SHOULD 4779 02:42:23,600 --> 02:42:28,438 PILD SHOULDBUILD IT ON PART OF R 4780 02:42:28,505 --> 02:42:29,639 DATASET, THEN WITHOUT CHANGING 4781 02:42:29,706 --> 02:42:31,575 ANY ASPECTS, WITHOUT CHANGING 4782 02:42:31,641 --> 02:42:32,776 ANY OF THE PARAMETERS YOU 4783 02:42:32,843 --> 02:42:35,078 SHOULD -- IN AN INDEPENDENT 4784 02:42:35,145 --> 02:42:35,412 DATASET. 4785 02:42:35,479 --> 02:42:37,647 THAT COULD BE A WITHHELD DATASET 4786 02:42:37,714 --> 02:42:39,616 OR A WHOLE NEW DATASET. 4787 02:42:39,683 --> 02:42:41,618 AM I CORRECT IN THE BASIC 4788 02:42:41,685 --> 02:42:42,419 UNDERSTANDING OF THAT 4789 02:42:42,486 --> 02:42:42,786 RECOMMENDATION? 4790 02:42:42,853 --> 02:42:43,253 >> THAT IS CORRECT. 4791 02:42:43,320 --> 02:42:47,858 YOU KNOW, AND THERE'S TWO AN 4792 02:42:47,924 --> 02:42:50,260 DWEANGLESWITH THIS. 4793 02:42:50,327 --> 02:42:52,095 I STARTED THIS IN MY OWN LAB BUT 4794 02:42:52,162 --> 02:42:54,731 ALL THE STATISTICS FOLKS, 4795 02:42:54,798 --> 02:42:56,032 EARMUFF, BUT IN MY LAB, WHAT 4796 02:42:56,099 --> 02:42:58,735 I'VE BEEN TRYING TO GET ACROSS 4797 02:42:58,802 --> 02:43:01,271 TO THE GROUP IS THAT YOU DO 4798 02:43:01,338 --> 02:43:03,473 EXACTLY WHAT YOU SAY, YOU DO 4799 02:43:03,540 --> 02:43:10,013 EVERYTHING ALL IN A COMPLET 4800 02:43:10,080 --> 02:43:10,647 COMPLETELY -- PART OF YOUR 4801 02:43:10,714 --> 02:43:12,349 DATASET, ALL THE WAY DOWN, YOU 4802 02:43:12,415 --> 02:43:14,117 CAN REPLICATE IT WITHIN THE SAME 4803 02:43:14,184 --> 02:43:15,886 DATASET AND THEN IDEALLY, THE 4804 02:43:15,952 --> 02:43:17,888 BEST BEST PRACTICE IS YOU HAVE A 4805 02:43:17,954 --> 02:43:19,823 COMPLETELY DIFFERENT DATASET, 4806 02:43:19,890 --> 02:43:20,824 DIFFERENT COLLECTION EACH AND 4807 02:43:20,891 --> 02:43:22,359 YOU VALIDATE IT IN A THIRD ONE. 4808 02:43:22,425 --> 02:43:23,426 USUALLY IF YOU CAN GET THROUGH 4809 02:43:23,493 --> 02:43:26,596 ALL THOSE PIECES THAT YOU'VE 4810 02:43:26,663 --> 02:43:29,900 KIND OF NAILED THE FINDING. 4811 02:43:29,966 --> 02:43:33,503 >> TO MY MIND, THAT PARALLELS 4812 02:43:33,570 --> 02:43:35,238 THE EVOLUTION THAT WENT IN THE 4813 02:43:35,305 --> 02:43:37,741 GWAS ASPECTS OF GENOMICS, I 4814 02:43:37,807 --> 02:43:41,878 THINK, RIGHT, WHERE IN ORDER TO 4815 02:43:41,945 --> 02:43:43,213 PUBLISH A GENETIC ASSOCIATION 4816 02:43:43,280 --> 02:43:44,648 RESULT, YOU NEEDED TO 4817 02:43:44,714 --> 02:43:46,383 ESSENTIALLY REPLICATE WHAT YOU 4818 02:43:46,449 --> 02:43:48,418 DID IN AN INDEPENDENT DATASET. 4819 02:43:48,485 --> 02:43:49,886 IS THAT MORE OR LESS TRUE? 4820 02:43:49,953 --> 02:43:51,388 LAURA IS LOOKING AT ME 4821 02:43:51,454 --> 02:43:51,688 SKEPTICALLY. 4822 02:43:51,755 --> 02:43:54,024 >> THAT WAS CERTAINLY TRUE AT 4823 02:43:54,090 --> 02:43:55,559 THE START, BECAUSE WHEN PEOPLE 4824 02:43:55,625 --> 02:43:57,627 HAD INDIVIDUAL STUDIES, THEY 4825 02:43:57,694 --> 02:43:59,829 WOULD TEST MULTIPLE VARIANTS, 4826 02:43:59,896 --> 02:44:03,733 RIGHT, OM UP WITH -- THERE'S 4827 02:44:03,800 --> 02:44:05,602 ACTUALLY A PARAGRAPH, THERE'S A 4828 02:44:05,669 --> 02:44:06,903 PIECE IN HERE ABOUT 4829 02:44:06,970 --> 02:44:07,470 META-ANALYSIS. 4830 02:44:07,537 --> 02:44:09,005 SO WHEN YOU GET OUT TO HAVING 4831 02:44:09,072 --> 02:44:11,074 MANY, MANY, MANY, MANY, MANY 4832 02:44:11,141 --> 02:44:12,809 STUDIES, YOU MAY STILL HAVE BIAS 4833 02:44:12,876 --> 02:44:15,212 WHEN YOU PUT THEM TOGETHER FOR 4834 02:44:15,278 --> 02:44:18,348 META-ANALYSIS, AND IT TURNS OUT 4835 02:44:18,415 --> 02:44:21,985 TO BE LESS TO HAVE A REPLICATION 4836 02:44:22,052 --> 02:44:22,586 GROUP. 4837 02:44:22,652 --> 02:44:23,853 THE DIFFERENCE, I THINK, BETWEEN 4838 02:44:23,920 --> 02:44:25,155 THESE TWO IS THAT WHEN YOU DO 4839 02:44:25,222 --> 02:44:26,690 GENETIC STUDIES, YOU HAVE A 4840 02:44:26,756 --> 02:44:27,657 REALLY SET THING THAT YOU'RE 4841 02:44:27,724 --> 02:44:28,191 DOING. 4842 02:44:28,258 --> 02:44:29,392 YOU ARE TESTING THE VARIANTS. 4843 02:44:29,459 --> 02:44:30,927 WHEREAS WHEN YOU'RE PREDICTING 4844 02:44:30,994 --> 02:44:32,028 AND YOU'VE TWEAKED AND YOU'VE 4845 02:44:32,095 --> 02:44:33,863 GONE DOWN THIS PATHWAY, THEN I 4846 02:44:33,930 --> 02:44:36,499 THINK IT BECOMES MORE IMPORTANT. 4847 02:44:36,566 --> 02:44:38,668 >> RIGHT, WHEN YOU HAVE A MODEL 4848 02:44:38,735 --> 02:44:41,738 THAT YOU FIT PARAMETERS TO OR 4849 02:44:41,805 --> 02:44:42,606 DIMENSIONALITY REDUCTION THAT 4850 02:44:42,672 --> 02:44:44,040 YOU'RE DOING, THAT YOU'RE 4851 02:44:44,107 --> 02:44:46,276 FITTING, AGAIN, PERHAPS TERES 4852 02:44:46,343 --> 02:44:48,478 TO, YOU NEED TO MAKE SURE THAT 4853 02:44:48,545 --> 02:44:48,812 REPLICATES. 4854 02:44:48,878 --> 02:44:50,013 LET ME JUST FURTHER CHALLENGE 4855 02:44:50,080 --> 02:44:50,680 THE GROUP ON THIS. 4856 02:44:50,747 --> 02:44:52,649 IN FACT, THIS IS INHERENT IN 4857 02:44:52,716 --> 02:44:53,516 SOME OF THE GRANTS WE'RE GOING 4858 02:44:53,583 --> 02:44:55,819 TO TALK ABOUT TOMORROW. 4859 02:44:55,885 --> 02:44:57,520 OFTEN IN THESE LARGE DATASET 4860 02:44:57,587 --> 02:44:58,321 THINGS, PARTICULARLY IN THOSE 4861 02:44:58,388 --> 02:45:00,924 THAT ARE AIMED AT PREDICTION, 4862 02:45:00,991 --> 02:45:03,760 YOU'LL SEE A MODEL BUILT AND 4863 02:45:03,827 --> 02:45:06,062 THEN WITH 10% OF THE DATA LEFT 4864 02:45:06,129 --> 02:45:06,830 OUT. 4865 02:45:06,896 --> 02:45:09,799 OR 5% OF THE DATA LEFT OUT. 4866 02:45:09,866 --> 02:45:13,937 AND THEN TESTED O ON THE REMAING 4867 02:45:14,004 --> 02:45:16,006 5% AND THEN THE MODEL REITERATED 4868 02:45:16,072 --> 02:45:18,842 ON A DIFFERENT 95% AND 5%. 4869 02:45:18,908 --> 02:45:24,514 I FORGET THE NAME FOR THIS, BUT 4870 02:45:24,581 --> 02:45:24,781 TENFOLD -- 4871 02:45:24,848 --> 02:45:25,682 >> CROSS VALIDATION. 4872 02:45:25,749 --> 02:45:27,317 >> TENFOLD CROSS VALIDATION. 4873 02:45:27,384 --> 02:45:29,486 WAS THERE -- I DON'T WANT TO 4874 02:45:29,552 --> 02:45:31,121 READ IN THE RECOMMENDATION, BUT 4875 02:45:31,187 --> 02:45:31,988 IT SEEMS LIKE THIS 4876 02:45:32,055 --> 02:45:33,390 RECOMMENDATION DOES NOT SUPPORT 4877 02:45:33,456 --> 02:45:42,332 AN END FOLD, A PURE INDEPENDENT 4878 02:45:42,399 --> 02:45:44,534 VERSUS AN END FOLD THAT CAN BE 4879 02:45:44,601 --> 02:45:46,936 AGREED UPON IN THE FIELD AS 4880 02:45:47,003 --> 02:45:49,205 BEING PRER PREFERABLE? 4881 02:45:49,272 --> 02:45:53,076 >> WELL, SO I THINK -- SO THE 4882 02:45:53,143 --> 02:45:56,346 CROSS VALIDATION IS A VERY TRIED 4883 02:45:56,413 --> 02:45:58,748 AND TRUE APPROACH TO ACTUALLY 4884 02:45:58,815 --> 02:46:00,150 REPLICATING OUTCOMES DATA, SO I 4885 02:46:00,216 --> 02:46:04,888 DON'T THINK YOU'D WABTD TO WANTI 4886 02:46:04,954 --> 02:46:06,122 DON'T THINK THAT'S A NEGATIVE, 4887 02:46:06,189 --> 02:46:07,023 PER SE. 4888 02:46:07,090 --> 02:46:08,358 IT'S JUST ANOTHER METHOD OF 4889 02:46:08,425 --> 02:46:12,529 DOING KIND OF THE -- WHAT DID 4890 02:46:12,595 --> 02:46:15,465 THEY CALL IT EARLIER, HOLDING 4891 02:46:15,532 --> 02:46:17,100 LIKE A DATASET OUT. 4892 02:46:17,167 --> 02:46:21,171 SO THOSE ARE IN THEORY, KIND OF 4893 02:46:21,237 --> 02:46:23,273 THEY'RE THE SAME, YOU KNOW, SO I 4894 02:46:23,340 --> 02:46:25,975 DON'T KNOW IF YOU'D WANT TO -- 4895 02:46:26,042 --> 02:46:28,144 WE NEVER GOT TO THAT MACHINE 4896 02:46:28,211 --> 02:46:30,113 LEARNING PRACTICES OR NOTHING 4897 02:46:30,180 --> 02:46:33,750 LIKE THAT, BUT THAT'S JUST MY 4898 02:46:33,817 --> 02:46:34,818 EXPERT OPINION THAT MAYBE SOME 4899 02:46:34,884 --> 02:46:36,152 PEOPLE DISAGREE, BUT I THINK YOU 4900 02:46:36,219 --> 02:46:37,120 HAVE TO BE CAREFUL ON THAT. 4901 02:46:37,187 --> 02:46:38,321 >> OKAY. 4902 02:46:38,388 --> 02:46:40,223 ANY OTHER COMMENTS? 4903 02:46:40,290 --> 02:46:40,523 ALL RIGHT. 4904 02:46:40,590 --> 02:46:41,291 THANK YOU. 4905 02:46:41,358 --> 02:46:45,862 I THINK WE WOULD LIKE -- I 4906 02:46:45,929 --> 02:46:47,630 DIDN'T HEAR ANY SPECIFIC 4907 02:46:47,697 --> 02:46:49,132 RECOMMENDATIONS FOR EDITS. 4908 02:46:49,199 --> 02:46:50,467 SO I THINK WHAT WE'D LIKE TO 4909 02:46:50,533 --> 02:46:51,768 KNOW IS WHETHER THIS REPORT CAN 4910 02:46:51,835 --> 02:46:56,773 BE ACCEPTED IN ITS CURRENT FORM. 4911 02:46:56,840 --> 02:46:58,074 DO I HAVE A MOTION TO ACCEPT THE 4912 02:46:58,141 --> 02:46:59,409 REPORT IN ITS CURRENT FORM? 4913 02:46:59,476 --> 02:47:04,114 I SEE A MOTION AND A SECOND. 4914 02:47:04,180 --> 02:47:05,415 LET'S TAKE A VOTE. 4915 02:47:05,482 --> 02:47:06,483 PLEASE DO USE ZOOM TO VOTE AND 4916 02:47:06,549 --> 02:47:08,585 RAISE YOUR HAND IN ZOOM. 4917 02:47:08,651 --> 02:47:11,521 SO THIS IS A VOTE TO ACCEPT THE 4918 02:47:11,588 --> 02:47:21,831 REPORT IN ITS CURRENT FORM. 4919 02:47:21,898 --> 02:47:22,999 HANDS DOWN NOW. 4920 02:47:23,066 --> 02:47:24,601 ANYONE VOTING AGAINST ACCEPTING 4921 02:47:24,667 --> 02:47:31,107 THE REPORT IN ITS CURRENT FORM? 4922 02:47:31,174 --> 02:47:33,176 AND IS ANYONE ABSTAINING FROM 4923 02:47:33,243 --> 02:47:34,177 VOTING ON THE ACCEPTANCE OF THE 4924 02:47:34,244 --> 02:47:37,580 REPORT? 4925 02:47:37,647 --> 02:47:37,781 NO? 4926 02:47:37,847 --> 02:47:38,415 ALL RIGHT. 4927 02:47:38,481 --> 02:47:40,817 WELL, THANK YOU VERY MUCH, LAURA 4928 02:47:40,884 --> 02:47:42,152 AND DAMIEN AND EVERYONE WHO 4929 02:47:42,218 --> 02:47:43,153 PARTICIPATED ON THE WORK GROUP, 4930 02:47:43,219 --> 02:47:46,189 AND I WANT TO ALSO ESPECIALLY 4931 02:47:46,256 --> 02:47:49,826 THANK THE NIMH STAFF, TRACY, 4932 02:47:49,893 --> 02:47:53,196 JONATHAN, AND LAURA AND ANYONE 4933 02:47:53,263 --> 02:47:54,964 ELSE FROM NIMH? 4934 02:47:55,031 --> 02:47:56,032 OR A LOT OF FOLKS FROM NIMH. 4935 02:47:56,099 --> 02:47:56,599 GO AHEAD. 4936 02:47:56,666 --> 02:47:59,102 >> WE HAD A LARGE GROUP 4937 02:47:59,169 --> 02:48:01,271 REPRESENTATIVE FROM EACH 4938 02:48:01,337 --> 02:48:02,071 SUBMISSION PARTICIPATED. 4939 02:48:02,138 --> 02:48:04,140 >> I KNOW THEY WORKED EQUALLY 4940 02:48:04,207 --> 02:48:05,542 HARD IN BETWEEN THE MEETINGS, 4941 02:48:05,608 --> 02:48:06,976 MAKING SURE TO PROGRESS THINGS. 4942 02:48:07,043 --> 02:48:07,977 SO THANK YOU VERY, VERY MUCH. 4943 02:48:08,044 --> 02:48:10,513 WE REALLY APPRECIATE IT. 4944 02:48:10,580 --> 02:48:11,815 >> THANK YOU ALL. 4945 02:48:11,881 --> 02:48:13,850 >> THANK YOU. 4946 02:48:13,917 --> 02:48:14,951 >> LET ME JUST SAY TWO THINGS 4947 02:48:15,018 --> 02:48:16,853 BEFORE WE MOVE ON. 4948 02:48:16,920 --> 02:48:19,355 NUMBER ONE, NIMH STAFF WILL BE 4949 02:48:19,422 --> 02:48:20,790 LOOKING TO THE REPORT TO SEE IN 4950 02:48:20,857 --> 02:48:22,525 ADDITION TO PUBLISHING ON THE 4951 02:48:22,592 --> 02:48:23,726 WEB WHAT OUR NEXT STEPS AND 4952 02:48:23,793 --> 02:48:24,828 WE'LL BRING THAT BACK TO THIS 4953 02:48:24,894 --> 02:48:26,162 GROUP SO THAT YOU UNDERSTAND 4954 02:48:26,229 --> 02:48:27,797 WHAT THE FOLLOW-UP HAS BEEN AND 4955 02:48:27,864 --> 02:48:29,532 WE'LL LOOK AT WAYS OF EVALUATING 4956 02:48:29,599 --> 02:48:30,667 THE IMPACT OF THE REPORT AS 4957 02:48:30,733 --> 02:48:32,936 WELL, SO THANK YOU. 4958 02:48:33,002 --> 02:48:33,903 THE SECOND THING I WANT TO SAY 4959 02:48:33,970 --> 02:48:35,104 IS WE'RE RUNNING ALMOST A 4960 02:48:35,171 --> 02:48:35,772 HALF-HOUR LATE. 4961 02:48:35,839 --> 02:48:36,873 I WANT TO MAKE SURE THAT PEOPLE 4962 02:48:36,940 --> 02:48:38,274 IN THE AUDIENCE, PARTICULARLY 4963 02:48:38,341 --> 02:48:39,476 THOSE WHO ARE HERE FOR THE 4964 02:48:39,542 --> 02:48:41,778 PUBLIC COMMENT SESSION, KNOW 4965 02:48:41,845 --> 02:48:42,345 THAT. 4966 02:48:42,412 --> 02:48:44,848 WE ARE SCHEDULED TO GO TO 4967 02:48:44,914 --> 02:48:45,715 4:30 WITH CONCEPT CLEARANCES, 4968 02:48:45,782 --> 02:48:47,617 BUT I IMAGINE IT WILL GO A BIT 4969 02:48:47,684 --> 02:48:48,251 BEYOND THAT. 4970 02:48:48,318 --> 02:48:50,420 BUT WE WILL GET TO THE PUBLIC 4971 02:48:50,487 --> 02:48:51,521 COMMENT SESSION, IT JUST MAY BE 4972 02:48:51,588 --> 02:48:53,823 A LITTLE BIT DELAYED. 4973 02:48:53,890 --> 02:48:56,626 SO WITH THAT, I THINK WE'LL MOVE 4974 02:48:56,693 --> 02:49:03,766 ON TO CONCEPT CLEARANCES. 4975 02:49:03,833 --> 02:49:06,936 AS YOU KNOW, EACH COUNCIL 4976 02:49:07,003 --> 02:49:09,138 MEETING, NIMH STAFF PRESENTS 4977 02:49:09,205 --> 02:49:12,509 SEVERAL CONCEPTS, THE PURPOSE OF 4978 02:49:12,575 --> 02:49:13,710 THESE CONCEPT CLEARANCES IS FOR 4979 02:49:13,776 --> 02:49:15,745 NIMH STAFF AND LEADERSHIP TO 4980 02:49:15,812 --> 02:49:17,547 RECEIVE EARLY FEEDBACK ON THESE 4981 02:49:17,614 --> 02:49:19,182 POTENTIAL FUTURE RESEARCH 4982 02:49:19,249 --> 02:49:19,849 INITIATIVES. 4983 02:49:19,916 --> 02:49:21,484 INCLUDING SUGGESTIONS TO HELP 4984 02:49:21,551 --> 02:49:25,121 BRING FURTHER SHAPE TO THEM. 4985 02:49:25,188 --> 02:49:26,422 A BRIEF DESCRIPTION OF EACH 4986 02:49:26,489 --> 02:49:27,624 COMMENT WAS MADE AVAILABLE TO 4987 02:49:27,690 --> 02:49:29,692 YOU VIA THE ASR, THAT'S THE 4988 02:49:29,759 --> 02:49:31,127 SOFTWARE WE USE FOR GRANTS. 4989 02:49:31,194 --> 02:49:35,498 WITH YOUR FEEDBACK, NIMH AIMS TO 4990 02:49:35,565 --> 02:49:36,799 PROCEED WITH THE RESEARCH 4991 02:49:36,866 --> 02:49:37,133 ACTIVITY. 4992 02:49:37,200 --> 02:49:38,101 HOWEVER, THE PUBLICATION AND 4993 02:49:38,167 --> 02:49:39,302 TIMING ARE NOT CERTAIN AND ALSO 4994 02:49:39,369 --> 02:49:40,637 DEPEND ON SUFFICIENT FUNDS BEING 4995 02:49:40,703 --> 02:49:43,573 AVAILABLE. 4996 02:49:43,640 --> 02:49:44,874 ONCE PRESENTED PUBLICLY AT 4997 02:49:44,941 --> 02:49:46,309 COUNCIL, CONCEPTS ARE POSTED ON 4998 02:49:46,376 --> 02:49:47,944 THE NIMH WEBSITE AND AVAILABLE 4999 02:49:48,011 --> 02:49:50,680 FOR FURTHER COMMENT. 5000 02:49:50,747 --> 02:49:51,548 FOR THE PURPOSE OF TODAY'S 5001 02:49:51,614 --> 02:49:53,149 DISCUSSION, WE'VE ASSIGNED TWO 5002 02:49:53,216 --> 02:49:55,184 COUNCILMEMBERS TO EACH CONCEPT, 5003 02:49:55,251 --> 02:49:56,252 THOSE WE WELCOME FEEDBACK FROM 5004 02:49:56,319 --> 02:49:58,221 ANY MEMBERS OF COUNCIL. 5005 02:49:58,288 --> 02:50:00,423 THE FIRST CONCEPT WILL BE 5006 02:50:00,490 --> 02:50:04,160 PRESENTED BY THE DIVISION OF 5007 02:50:04,227 --> 02:50:05,361 TRANSLATIONAL RESEARCH, AND THE 5008 02:50:05,428 --> 02:50:06,996 CONCEPT IS ON NEUROMODULATION 5009 02:50:07,063 --> 02:50:08,565 AND NEUROSTIMULATION DEVICE 5010 02:50:08,631 --> 02:50:09,265 DEVELOPMENT FOR MENTAL HEALTH 5011 02:50:09,332 --> 02:50:19,576 APPLICATIONS. 5012 02:50:49,806 --> 02:50:56,346 >> HELLO, I'M LIZZY ANKUDOWICH, 5013 02:50:56,412 --> 02:50:57,580 I HAVE THE PLEASURE OF 5014 02:50:57,647 --> 02:51:00,550 PRESENTING TWO CONCEPTS ON MAF 5015 02:51:00,617 --> 02:51:01,684 BEHALF OF MY COLLEAGUE, 5016 02:51:01,751 --> 02:51:04,187 DR. JESSICA TILLMAN. 5017 02:51:04,253 --> 02:51:05,588 THE FIRST IS CALLED 5018 02:51:05,655 --> 02:51:07,523 NEUROMODULATION AND 5019 02:51:07,590 --> 02:51:08,958 NEUROSTIMULATION DEVICE. 5020 02:51:09,025 --> 02:51:10,760 THE GOAL OF THIS CONCEPT IS TO 5021 02:51:10,827 --> 02:51:12,362 ENCOURAGE THE DEVELOPMENT OF 5022 02:51:12,428 --> 02:51:13,696 NOVEL BRAIN STIMULATION DEVICES 5023 02:51:13,763 --> 02:51:15,698 TO ENABLE IMPROVED DELIVERY OF 5024 02:51:15,765 --> 02:51:18,401 BOTH BRAIN STIMULATION FOR THE 5025 02:51:18,468 --> 02:51:19,869 TREATMENT OF DELIVERY OF BRAIN 5026 02:51:19,936 --> 02:51:25,642 STIMULATION FOR THE -- WITH THE 5027 02:51:25,708 --> 02:51:26,676 OVERARCHING GOALS OF IMPROVING 5028 02:51:26,743 --> 02:51:29,012 THE EFFECTIVENESS OF EXISTING 5029 02:51:29,078 --> 02:51:30,980 DEVICES, DEVELOPING NOVEL 5030 02:51:31,047 --> 02:51:33,716 TECHNOLOGIES, AND DESIGNING 5031 02:51:33,783 --> 02:51:35,318 STUDIES IN WAYS THAT WILL 5032 02:51:35,385 --> 02:51:37,053 OPTIMIZE FOR EVENTUAL REGULATORY 5033 02:51:37,120 --> 02:51:40,023 APPROVAL. 5034 02:51:40,089 --> 02:51:41,991 THE USE OF BRAIN STIMULATION 5035 02:51:42,058 --> 02:51:44,527 DEVICES PROVIDES A UNIQUE 5036 02:51:44,594 --> 02:51:45,928 OPPORTUNITY TO DEVELOP NOVEL 5037 02:51:45,995 --> 02:51:47,263 TREATMENTS FOR SERIOUS MENTAL 5038 02:51:47,330 --> 02:51:47,897 ILLNESS. 5039 02:51:47,964 --> 02:51:50,266 FOR CONTEXT, CURRENTLY USED 5040 02:51:50,333 --> 02:51:52,035 DEVICES INCLUDE 5041 02:51:52,101 --> 02:51:53,670 ELECTROCONVULSIVE THERAPY OR ECT 5042 02:51:53,736 --> 02:51:56,139 WHICH PROVIDES THE MOST 5043 02:51:56,205 --> 02:51:57,573 EFFICACIOUS I INTERVENTION FOR 5044 02:51:57,640 --> 02:51:59,208 SERIOUS DEPRESSION AND 5045 02:51:59,275 --> 02:52:00,176 TRANSCRANIAL MAGNETIC 5046 02:52:00,243 --> 02:52:01,878 STIMULATION OR TMS WHICH IS A 5047 02:52:01,944 --> 02:52:03,112 MORE RECENTLY CLEARED TREATMENT 5048 02:52:03,179 --> 02:52:03,880 FOR DEPRESSION. 5049 02:52:03,946 --> 02:52:05,982 HOWEVER, THESE SUCCESSES 5050 02:52:06,049 --> 02:52:06,949 DEMONSTRATE THE POTENTIAL TO 5051 02:52:07,016 --> 02:52:09,352 IMPROVE CLINICAL CARE, 5052 02:52:09,419 --> 02:52:11,754 LIMITATIONS OF A FEW EXISTING 5053 02:52:11,821 --> 02:52:13,156 FDA-CLEARED DEVICES SUCH AS 5054 02:52:13,222 --> 02:52:15,124 COGNITIVE SIDE EFFECTS OF ECT 5055 02:52:15,191 --> 02:52:17,326 AND VARIABILITY IN RESPONSE OF 5056 02:52:17,393 --> 02:52:20,763 TMS MAY HAMPER WIDER-SPREAD 5057 02:52:20,830 --> 02:52:21,631 CLINICAL USE. 5058 02:52:21,698 --> 02:52:22,865 INNOVATIVE BRAIN STIMULATION 5059 02:52:22,932 --> 02:52:24,701 DEVICES AND NOVEL APPROACHES TO 5060 02:52:24,767 --> 02:52:26,636 EXISTING DEVICES ARE URGENTLY 5061 02:52:26,703 --> 02:52:28,638 NEEDED TO DEVELOP EFFICACIOUS 5062 02:52:28,705 --> 02:52:30,273 TREATMENTS THAT WILL BE MORE 5063 02:52:30,339 --> 02:52:32,341 WIDELY UTILIZED ACROSS THE 5064 02:52:32,408 --> 02:52:35,111 SPECTRUM OF DISORDERS. 5065 02:52:35,178 --> 02:52:36,879 NEW DEVICES DEVELOPED WITH 5066 02:52:36,946 --> 02:52:38,381 SPECIFIC FOCUS ON FEATURES 5067 02:52:38,448 --> 02:52:40,049 UNIQUE TO SERIOUS MENTAL ILLNESS 5068 02:52:40,116 --> 02:52:42,318 ARE NEEDED TO EXPLORE MORE FULLY 5069 02:52:42,385 --> 02:52:43,853 THE POTENTIAL OF BRAIN 5070 02:52:43,920 --> 02:52:45,288 STIMULATION THERAPIES. 5071 02:52:45,354 --> 02:52:46,889 THIS SLIDE LISTS SEVERAL 5072 02:52:46,956 --> 02:52:49,959 CHALLENGES WHICH MOTIVATE THIS 5073 02:52:50,026 --> 02:52:51,728 CONCEPT AS WELL AS HOW WE EXPECT 5074 02:52:51,794 --> 02:52:56,466 THIS FUNDING OPPORTUNITY CONCEPT 5075 02:52:56,532 --> 02:52:57,467 TO ADDRESS THOSE CHALLENGES. 5076 02:52:57,533 --> 02:52:59,869 ADDRESSING THE LIMITED NUMBER OF 5077 02:52:59,936 --> 02:53:01,270 CURRENTLY AVAILABLE 5078 02:53:01,337 --> 02:53:02,438 TECHNOLOGIES, OVERCOMING THE 5079 02:53:02,505 --> 02:53:03,873 LIMITATIONS OF CURRENT DEVICES 5080 02:53:03,940 --> 02:53:05,708 WHICH HAMPER THEIR WIDER SPREAD 5081 02:53:05,775 --> 02:53:10,079 ADOPTION IN CLINICAL PRACTICE, 5082 02:53:10,146 --> 02:53:11,114 DEVELOPING DEVICES FOCUSED ON 5083 02:53:11,180 --> 02:53:13,249 THE NETWORK PATHOLOGIES SPECIFIC 5084 02:53:13,316 --> 02:53:14,450 TO MENTAL DISORDERS AND 5085 02:53:14,517 --> 02:53:16,185 FACILITATING A PATH TOWARD 5086 02:53:16,252 --> 02:53:17,587 REGULATORY APPROVAL. 5087 02:53:17,653 --> 02:53:20,323 TO ILLUSTRATE, DEEP BRAIN 5088 02:53:20,389 --> 02:53:22,058 STIMULATION AND VAGAL NERVE 5089 02:53:22,125 --> 02:53:23,593 STIMULATION ARE TWO APPROACHES 5090 02:53:23,659 --> 02:53:24,694 THAT WERE DEVELOPED FOR THE 5091 02:53:24,761 --> 02:53:26,395 TREATMENT OF PARKINSON'S DISEASE 5092 02:53:26,462 --> 02:53:26,729 AND EPILEPSY. 5093 02:53:26,796 --> 02:53:28,498 THEY HAVE SUBSEQUENTLY BEEN 5094 02:53:28,564 --> 02:53:29,799 STUDIED WITH MINIMAL 5095 02:53:29,866 --> 02:53:31,134 MODIFICATION FOR USE IN MENTAL 5096 02:53:31,200 --> 02:53:33,736 DISORDERS WITH MIXED RESULTS. 5097 02:53:33,803 --> 02:53:35,471 NEW DEVICES INFORMED BY BASIC 5098 02:53:35,538 --> 02:53:37,006 AND CLINICAL SCIENCE FINDINGS IN 5099 02:53:37,073 --> 02:53:40,042 MENTAL HEALTH RESEARCH MAY 5100 02:53:40,109 --> 02:53:42,311 PROVIDE IMPROVED TREATMENT. 5101 02:53:42,378 --> 02:53:45,348 MOREOVER, WHILE CURRENT DBS 5102 02:53:45,414 --> 02:53:46,816 ELECTRODES ARE LIMITED TO ONE OR 5103 02:53:46,883 --> 02:53:47,850 TWO STIMULATION SITES, 5104 02:53:47,917 --> 02:53:49,085 NEUROIMAGING STUDIES HAVE 5105 02:53:49,152 --> 02:53:52,855 DEMONSTRATED THE DISTRIBUTED 5106 02:53:52,922 --> 02:53:54,524 NETWORK-BASED NATURE OF MENTAL 5107 02:53:54,590 --> 02:53:54,957 DISORDERS. 5108 02:53:55,024 --> 02:53:57,260 THEREFORE, DISTRIBUTED 5109 02:53:57,326 --> 02:53:59,595 MULTIFOCAL ARRAY ELECTRODES MAY 5110 02:53:59,662 --> 02:54:00,496 BE NECESSARY TO MODULATE 5111 02:54:00,563 --> 02:54:02,331 NETWORKS BACK TO A DESIRED 5112 02:54:02,398 --> 02:54:02,565 STATE. 5113 02:54:02,632 --> 02:54:05,568 NEW FORMS OF ENERGY SUCH AS 5114 02:54:05,635 --> 02:54:06,135 ULTRASOUND HAVE ALSO HAD THE 5115 02:54:06,202 --> 02:54:07,470 POTENTIAL TO BE INCORPORATED 5116 02:54:07,537 --> 02:54:09,105 INTO THE NEXT GENERATION OF 5117 02:54:09,172 --> 02:54:12,508 BRAIN STIMULATION DEVICES. 5118 02:54:12,575 --> 02:54:15,945 THESE FOUNDATIONAL STUDIES AND 5119 02:54:16,012 --> 02:54:17,246 DEVICE DEVELOPMENT IN MENTAL 5120 02:54:17,313 --> 02:54:19,248 HEALTH MAY STREAMLINE PATHWAYS 5121 02:54:19,315 --> 02:54:20,016 TOWARDS REGULATORY APPROVAL. 5122 02:54:20,082 --> 02:54:22,318 IN ADDITION TO DEVELOPING NEW 5123 02:54:22,385 --> 02:54:23,486 DEVICES, SIGNIFICANTLY ENHANCING 5124 02:54:23,553 --> 02:54:26,322 THE CAPABILITIES OF EXISTING 5125 02:54:26,389 --> 02:54:27,190 DEVICES ALSO PRESENTS AN 5126 02:54:27,256 --> 02:54:29,692 OPPORTUNITY TO IMPROVE CLINICAL 5127 02:54:29,759 --> 02:54:31,994 CARE. 5128 02:54:32,061 --> 02:54:33,629 THESE DEVICES ARE AMENABLE TO 5129 02:54:33,696 --> 02:54:35,131 HARDWARE AND SOFTWARE 5130 02:54:35,198 --> 02:54:36,032 MODIFICATIONS THAT CAN READILY 5131 02:54:36,098 --> 02:54:36,999 TRANSLATE TO IMPROVE PATIENT 5132 02:54:37,066 --> 02:54:37,333 CARE. 5133 02:54:37,400 --> 02:54:43,039 FOR EXAMPLE, APPROACHES THAT 5134 02:54:43,105 --> 02:54:47,210 IMPROVE THE DEPTH OR DELIVERY OF 5135 02:54:47,276 --> 02:54:49,178 TMS CAN IMPROVE RESPONSE RATES. 5136 02:54:49,245 --> 02:54:50,279 DEVELOPMENT OF SOFTWARE 5137 02:54:50,346 --> 02:54:51,480 CAPABILITY THAT COULD ENABLE US 5138 02:54:51,547 --> 02:54:53,449 TO CLOSE THE LOOP WITH A BRAIN 5139 02:54:53,516 --> 02:54:55,151 STIMULATION DEVICE USING 5140 02:54:55,218 --> 02:54:55,952 NEUROIMAGING OR NEURAL 5141 02:54:56,018 --> 02:54:57,153 RECORDINGS FROM INDIVIDUAL 5142 02:54:57,220 --> 02:54:58,454 PATIENTS, WE CAN USE THIS TO 5143 02:54:58,521 --> 02:54:59,889 GUIDE STIMULATION. 5144 02:54:59,956 --> 02:55:02,158 OR WE COULD DEVELOP AUGMENTED 5145 02:55:02,225 --> 02:55:03,793 REALITY DELIVERY SYSTEMS TO 5146 02:55:03,860 --> 02:55:06,529 ENABLE PRACTITIONERS TO 5147 02:55:06,596 --> 02:55:08,030 INTERACTIVELY TARGET REGIONS OF 5148 02:55:08,097 --> 02:55:09,031 INTEREST WITH STIMULATION. 5149 02:55:09,098 --> 02:55:10,867 AND ALTHOUGH ECT PROVIDES THE 5150 02:55:10,933 --> 02:55:12,301 BEST REMISSION RATES FOR 5151 02:55:12,368 --> 02:55:14,337 DEPRESSION, THE WIDESPREAD 5152 02:55:14,403 --> 02:55:16,405 GENERALIZED SEIZURE INDUCED BY 5153 02:55:16,472 --> 02:55:17,506 THE DEVICE PRODUCES COGNITIVE 5154 02:55:17,573 --> 02:55:19,375 SIDE EFFECTS THAT LIMIT ITS USE. 5155 02:55:19,442 --> 02:55:20,476 THEREFORE, DEVELOPMENT OF 5156 02:55:20,543 --> 02:55:22,111 DEVICES THAT COULD DELIVER MORE 5157 02:55:22,178 --> 02:55:25,281 FOCUSED STIMULATION RESULTING IN 5158 02:55:25,348 --> 02:55:27,183 A SMALLER CONTROLLABLE SEIZURE 5159 02:55:27,250 --> 02:55:29,151 COULD PRODUCE HIGH LEVELS OF 5160 02:55:29,218 --> 02:55:30,253 THERAPEUTIC RESPONSE WHILE 5161 02:55:30,319 --> 02:55:34,757 MINIMIZING SIDE EFFECTS. 5162 02:55:34,824 --> 02:55:38,761 THIS FINAL SLIDE LISTS A SET OF 5163 02:55:38,828 --> 02:55:40,396 TOPICS THAT INCLUDE BUT ARE NOT 5164 02:55:40,463 --> 02:55:43,266 LIMITED TO MULTIFOCAL 5165 02:55:43,332 --> 02:55:45,067 CAPABILITIES, DEVICES CAPABLE OF 5166 02:55:45,134 --> 02:55:46,269 CLOSED LOOP CONTROL, NEXT 5167 02:55:46,335 --> 02:55:47,937 GENERATION ECT DEVICE, 5168 02:55:48,004 --> 02:55:49,972 VALIDATION OF NOVEL ENERGY FORMS 5169 02:55:50,039 --> 02:55:51,374 SUCH AS TRANSCRANIAL ULTRASOUND, 5170 02:55:51,440 --> 02:55:52,708 MACHINE LEARNING SOFTWARE 5171 02:55:52,775 --> 02:55:55,311 CAPABLE OF INCORPORATING 5172 02:55:55,378 --> 02:55:57,380 PATIENT-SPECIFIC BIOMARKERS, AND 5173 02:55:57,446 --> 02:55:58,481 IMPROVED SHAM CONTROLS THAT 5174 02:55:58,547 --> 02:56:00,549 ENABLE MORE RELIABLE CONTROLLED 5175 02:56:00,616 --> 02:56:03,452 CLINICAL TRIALS. 5176 02:56:03,519 --> 02:56:04,453 SO THAT'S WHAT I HAVE FOR YOU 5177 02:56:04,520 --> 02:56:05,788 TODAY AND THE DISCUSSANTS FOR 5178 02:56:05,855 --> 02:56:15,164 THIS WURNTION ONE I WAS T -- 5179 02:56:15,231 --> 02:56:15,932 >> I CAN START. 5180 02:56:15,998 --> 02:56:17,900 THIS IS AN EXCELLENT CONCEPT 5181 02:56:17,967 --> 02:56:19,001 CLEARANCE AND I THINK IT 5182 02:56:19,068 --> 02:56:20,436 ADDRESSES A LOT OF REALLY 5183 02:56:20,503 --> 02:56:23,606 IMPORTANT DEVELOPMENTS IN THE 5184 02:56:23,673 --> 02:56:26,242 FIELD LIKE TRANSCRANIAL 5185 02:56:26,309 --> 02:56:27,176 ULTRASOUND. 5186 02:56:27,243 --> 02:56:29,145 ONE AREA THAT I THINK WOULD BE 5187 02:56:29,211 --> 02:56:31,213 GOOD TO SORT OF FURTHER DEVELOP 5188 02:56:31,280 --> 02:56:34,817 IS ACTUALLY STIMULATED, NO PUN 5189 02:56:34,884 --> 02:56:39,789 INTENDED, SOBP AND THE WORKSHOP 5190 02:56:39,855 --> 02:56:43,726 THAT NIMH HELD ON REALTIME FMRI 5191 02:56:43,793 --> 02:56:44,727 NEUROFEEDBACK AND WHETHER THAT 5192 02:56:44,794 --> 02:56:46,429 WOULD BE CONSIDERED UNDER THE 5193 02:56:46,495 --> 02:56:48,297 PURVIEW OF THIS CONCEPT 5194 02:56:48,364 --> 02:56:55,104 CLEARANCE TO INCLUDE REALTIME 5195 02:56:55,171 --> 02:56:57,573 FEEDBACK SUPPORT BID POTENTIAL 5196 02:56:57,640 --> 02:56:58,441 FUNDING OPPORTUNITY. 5197 02:56:58,507 --> 02:57:00,810 >> I THINK THAT'S A GREAT IDEA. 5198 02:57:00,876 --> 02:57:01,911 I AM WRITING IT DOWN. 5199 02:57:01,978 --> 02:57:03,112 I THINK THAT'S SOMETHING WE 5200 02:57:03,179 --> 02:57:03,980 DEFINITELY WANT TO THINK ABOUT 5201 02:57:04,046 --> 02:57:06,716 HOW TO INCORPORATE IN THE FUTURE 5202 02:57:06,782 --> 02:57:08,684 MOVING FORWARD, ESPECIALLY SINCE 5203 02:57:08,751 --> 02:57:10,720 WE'VE GOTTEN SUCH GREAT FEEDBACK 5204 02:57:10,786 --> 02:57:11,420 WITH THAT WORKSHOP. 5205 02:57:11,487 --> 02:57:12,655 >> MATT? 5206 02:57:12,722 --> 02:57:14,724 >> I'LL JUST ADD, ALSO STRONGLY 5207 02:57:14,790 --> 02:57:15,524 SUPPORT THIS. 5208 02:57:15,591 --> 02:57:18,260 REALLY WELL REASONED, GREAT NEED 5209 02:57:18,327 --> 02:57:19,895 FOR T MY ONE SUGGESTION WOULD BE 5210 02:57:19,962 --> 02:57:21,530 TO CONTINUE TO FOCUS ON THE USE 5211 02:57:21,597 --> 02:57:22,932 OF THESE DEVICES ON REALLY 5212 02:57:22,999 --> 02:57:26,902 DIFFICULT TO TREAT CONDITIONS. 5213 02:57:26,969 --> 02:57:28,404 YOU MEANT MENGSED DEPRESSION, 5214 02:57:28,471 --> 02:57:30,606 SUICIDE IS ANOTHER ONE, WE KNOW 5215 02:57:30,673 --> 02:57:31,474 ECT FOR INSTANCE HAS WORKED 5216 02:57:31,540 --> 02:57:33,242 REALLY WELL FOR DECADES, NOW 5217 02:57:33,309 --> 02:57:35,211 IT'S MUCH SAFER THAN IT USED TO 5218 02:57:35,277 --> 02:57:36,812 BE BUT STILL NOT WIDELY USED, 5219 02:57:36,879 --> 02:57:38,781 AND WE DON'T HAVE A LOT OF OTHER 5220 02:57:38,848 --> 02:57:40,983 TREATMENTS THAT WORK SO QUICKLY, 5221 02:57:41,050 --> 02:57:43,019 SO I THINK WORKING ON THESE 5222 02:57:43,085 --> 02:57:44,120 DIFFICULT TO TREAT AREAS SHOULD 5223 02:57:44,186 --> 02:57:46,889 BE A VITAL FIRST STEP. 5224 02:57:46,956 --> 02:57:47,523 NEXT STEP. 5225 02:57:47,590 --> 02:57:49,759 GREAT JOB. 5226 02:57:49,825 --> 02:57:51,160 >> ANY QUESTIONS OR COMMENTS 5227 02:57:51,227 --> 02:57:56,932 FROM OTHER MEMBERS OF COUNCIL? 5228 02:57:56,999 --> 02:57:58,768 THANK YOU VERY MUCH, AND LIZZY 5229 02:57:58,834 --> 02:57:59,935 IS GOING TO GO AHEAD AND PRESENT 5230 02:58:00,002 --> 02:58:01,404 THE NEXT ONE AS WELL, WHICH IS 5231 02:58:01,470 --> 02:58:03,139 ON UTILIZING INVASIVE RECORDING 5232 02:58:03,205 --> 02:58:04,540 AND STIMULATING OPPORTUNITIES IN 5233 02:58:04,607 --> 02:58:06,442 HUMANS TO ADVANCE NEURAL 5234 02:58:06,509 --> 02:58:07,576 CIRCUITRY UNDERSTANDING OF 5235 02:58:07,643 --> 02:58:18,054 MENTAL HEALTH DISORDERS. 5236 02:58:41,477 --> 02:58:43,112 >> DR. GORDON JUST INTRODUCE 5237 02:58:43,179 --> 02:58:46,148 THIS HAD SON O'CONNOR SEPTEMBER 5238 02:58:46,215 --> 02:58:46,982 THIS CONCEPT. 5239 02:58:47,049 --> 02:58:48,184 THE GOAL IS TO ENCOURAGE 5240 02:58:48,250 --> 02:58:49,318 RESEARCH UTILIZING INVASIVE 5241 02:58:49,385 --> 02:58:50,319 NEURAL RECORDING OPPORTUNITIES 5242 02:58:50,386 --> 02:58:52,521 IN HUMANS TO STUDY THE NEURAL 5243 02:58:52,588 --> 02:58:53,456 CIRCUITRY UNDERLYING MENTAL 5244 02:58:53,522 --> 02:58:57,226 HEALTH DISORDERS. 5245 02:58:57,293 --> 02:59:00,062 INVASIVE RECORDINGS PROVIDE A 5246 02:59:00,129 --> 02:59:02,398 WINDOW INTO THE HUMAN BRAIN BY 5247 02:59:02,465 --> 02:59:03,232 FACILITATING EXPLORATION OF THE 5248 02:59:03,299 --> 02:59:04,834 NEURAL CIRCUITRY UNDERLYING 5249 02:59:04,900 --> 02:59:06,402 COMPLEX MOODS, EMOTIONS, 5250 02:59:06,469 --> 02:59:07,937 COGNITIVE FUNCTIONS AND 5251 02:59:08,003 --> 02:59:11,207 BEHAVIORS WITH HIGH SPATIAL 5252 02:59:11,273 --> 02:59:11,474 PRECISION. 5253 02:59:11,540 --> 02:59:14,110 THE ABILITY TO STIMULATE VIA THE 5254 02:59:14,176 --> 02:59:15,311 SAME ELECTRODES ALLOWS FOR 5255 02:59:15,377 --> 02:59:16,912 DIRECT CAUSAL TESTS BY 5256 02:59:16,979 --> 02:59:18,447 MODULATING NETWORK DYNAMICS. 5257 02:59:18,514 --> 02:59:21,150 IN TERMS OF TREATMENT 5258 02:59:21,217 --> 02:59:22,251 DEVELOPMENT, ELUCIDATING THE 5259 02:59:22,318 --> 02:59:23,686 CIRCUITS UNDERLYING COMPLEX 5260 02:59:23,752 --> 02:59:27,990 HUMAN BEHAVIORS AND DETERMINING 5261 02:59:28,057 --> 02:59:29,425 HOW TO MANIPULATE THOSE CIRCUITS 5262 02:59:29,492 --> 02:59:31,160 INTO DESIRED STATES COULD INFORM 5263 02:59:31,227 --> 02:59:33,162 INVASIVE AND NONINVASIVE BRAIN 5264 02:59:33,229 --> 02:59:34,330 STIMULATION THERAPIES OF THE 5265 02:59:34,396 --> 02:59:34,730 FUTURE. 5266 02:59:34,797 --> 02:59:35,831 ALTHOUGH EARLY DEEP BRAIN 5267 02:59:35,898 --> 02:59:37,266 STIMULATION STUDIES FOR 5268 02:59:37,333 --> 02:59:39,301 TREATMENT REFRACTORY DEPRESSED 5269 02:59:39,368 --> 02:59:42,004 PATIENTS SHOW POTENTIAL, LARGER 5270 02:59:42,071 --> 02:59:43,739 PIVOTAL STUDIES HAVE BEEN UNABLE 5271 02:59:43,806 --> 02:59:45,341 TO DEMONSTRATE EV FA SEE, 5272 02:59:45,407 --> 02:59:46,742 HIGHLIGHTING THE NEED TO DEPEP 5273 02:59:46,809 --> 02:59:48,944 OUR UNDERSTANDING OF THE NEURAL 5274 02:59:49,011 --> 02:59:50,379 CIRCLE TRY OF MENTAL HEALTH 5275 02:59:50,446 --> 02:59:50,746 DISORDERS. 5276 02:59:50,813 --> 02:59:54,483 DESPITE THE CLINICAL CHALLENGE, 5277 02:59:54,550 --> 02:59:57,119 INVASIVE RECORDINGS PROVIDE AN 5278 02:59:57,186 --> 02:59:58,888 EXCELLENT OPPORTUNITY TO EXPLORE 5279 02:59:58,954 --> 03:00:00,656 THE CIRCUITRY UNDERLYING COMPLEX 5280 03:00:00,723 --> 03:00:01,857 HUMAN BEHAVIOR AND TO TRANSLATE 5281 03:00:01,924 --> 03:00:04,994 LESSONS FROM ANIMAL RESEARCH. 5282 03:00:05,060 --> 03:00:05,761 OPPORTUNITIES ARISE DURING THE 5283 03:00:05,828 --> 03:00:07,329 NORMAL TREATMENT COURSE OF A 5284 03:00:07,396 --> 03:00:10,132 VARIETY OF CLINICAL CONDITIONS 5285 03:00:10,199 --> 03:00:12,468 INCLUDING INTRAOPERATIVE MICRO 5286 03:00:12,535 --> 03:00:15,004 ELECTRODE OR STRIP RECORDINGS 5287 03:00:15,070 --> 03:00:18,207 DURING DBS SURGERY, SUBACUTE 5288 03:00:18,274 --> 03:00:21,043 EPILEPSY MONITORING OR ECOG, 5289 03:00:21,110 --> 03:00:22,811 DEPTH ELECTRODE RECORDINGS, 5290 03:00:22,878 --> 03:00:24,547 CHRONIC DEEP BRAIN STIMULATION 5291 03:00:24,613 --> 03:00:26,815 AND RESPONSIVE NEURAL 5292 03:00:26,882 --> 03:00:29,518 STIMULATION OR DBS/RNS DEVICES 5293 03:00:29,585 --> 03:00:31,921 CAPABLE OF BOTH RECORDING AND 5294 03:00:31,987 --> 03:00:33,556 STIMULATING, AND MANY OF THESE 5295 03:00:33,622 --> 03:00:34,456 OPPORTUNITIES ARISE IN PATIENTS 5296 03:00:34,523 --> 03:00:36,625 THAT ARE BEING IMPLANTED FOR 5297 03:00:36,692 --> 03:00:37,793 NON-MENTAL HEALTH-RELATED 5298 03:00:37,860 --> 03:00:39,395 CONDITIONS. 5299 03:00:39,461 --> 03:00:40,729 HOWEVER, MANY RELEVANT CLINICAL 5300 03:00:40,796 --> 03:00:43,365 POPULATIONS SUCH AS THOSE 5301 03:00:43,432 --> 03:00:43,999 WITH -- INDIVIDUALS WITH 5302 03:00:44,066 --> 03:00:46,769 EPILEPSY AND PARKINSON'S 5303 03:00:46,835 --> 03:00:47,903 REPRESENT PATIENT COHORTS WITH 5304 03:00:47,970 --> 03:00:49,672 CO-MORBID MENTAL HEALTH 5305 03:00:49,738 --> 03:00:51,507 DISORDERS. 5306 03:00:51,574 --> 03:00:53,042 CAREFUL STUDY OF FLUCTUATING 5307 03:00:53,108 --> 03:00:54,543 MOOD, COGNITIVE FUNCTION AND 5308 03:00:54,610 --> 03:00:56,045 BEHAVIOR OF PATIENTS WITH AND 5309 03:00:56,111 --> 03:00:58,647 WITHOUT MENTAL HEALTH DISORDERS 5310 03:00:58,714 --> 03:01:02,685 CAN PROVIDE UNIQUE INSIGHT INTO 5311 03:01:02,751 --> 03:01:04,653 BEHAVIORAL NETWORK DYNAMICS. 5312 03:01:04,720 --> 03:01:06,522 DIRECT STIMULATION WILL 5313 03:01:06,589 --> 03:01:08,257 COMPLEMENT RECORDINGS BY 5314 03:01:08,324 --> 03:01:10,392 ENABLING RESEARCHERS TO TEST 5315 03:01:10,459 --> 03:01:11,493 MECHANISTIC HYPOTHESES AND 5316 03:01:11,560 --> 03:01:13,329 EXPLORE THERAPEUTIC OPTIONS. 5317 03:01:13,395 --> 03:01:14,763 NETWORKS CORRELATED WITH MOOD, 5318 03:01:14,830 --> 03:01:16,932 COGNITION AND BEHAVIOR USING 5319 03:01:16,999 --> 03:01:18,901 DENSE BEHAVIORAL ASSESSMENTS CAN 5320 03:01:18,968 --> 03:01:22,171 BE MODULATED TO ASSESS FOR 5321 03:01:22,238 --> 03:01:23,939 BEHAVIORAL IMPROVEMENTS. 5322 03:01:24,006 --> 03:01:26,175 WHILE CURRENT DBS AND 5323 03:01:26,242 --> 03:01:28,010 NONINVASIVE BRAIN STIMULATION 5324 03:01:28,077 --> 03:01:29,712 THERAPIES TARGET LOCALIZED 5325 03:01:29,778 --> 03:01:30,613 AREAS, THIS RESEARCH MAY 5326 03:01:30,679 --> 03:01:32,081 DEMONSTRATE THE DISTRIBUTED 5327 03:01:32,147 --> 03:01:33,782 NODES AND CIRCUITS INVOLVED IN 5328 03:01:33,849 --> 03:01:35,985 DISORDERS AND, THEREFORE, INFORM 5329 03:01:36,051 --> 03:01:38,587 THE DESIGN OF NEW DEVICES AND 5330 03:01:38,654 --> 03:01:39,521 FUTURE THERAPIES. 5331 03:01:39,588 --> 03:01:41,657 THIS CONCEPT WOULD TARGET A GAP 5332 03:01:41,724 --> 03:01:43,492 IN THE SCIENTIFIC KNOWLEDGE OF 5333 03:01:43,559 --> 03:01:44,393 NEURAL CIRCUIT RELATED TO MENTAL 5334 03:01:44,460 --> 03:01:47,896 HEALTH DISORDERS. 5335 03:01:47,963 --> 03:01:49,098 RESEARCH RELATED TO THIS CONCEPT 5336 03:01:49,164 --> 03:01:50,432 MAY INCLUDE BUT IS NOT LIMITED 5337 03:01:50,499 --> 03:01:52,101 TO STUDIES OF ACUTE 5338 03:01:52,167 --> 03:01:53,269 INTEROPERATIVE RECORDINGS FROM 5339 03:01:53,335 --> 03:01:55,871 SINGLE UNIT OR STRIP ELECTRODES, 5340 03:01:55,938 --> 03:01:56,905 SUBACUTE RECORDINGS FROM 5341 03:01:56,972 --> 03:01:59,608 EPILEPSY MONITORING UNIT OR 5342 03:01:59,675 --> 03:02:02,244 RELATED SITUATIONS, CHRONIC 5343 03:02:02,311 --> 03:02:03,479 RECORD TRANSPORTATION RECORDING 5344 03:02:03,545 --> 03:02:05,881 AND STIMULATING DBS SYSTEMS, 5345 03:02:05,948 --> 03:02:10,619 RESEARCH DOMAIN CRITERIA OR 5346 03:02:10,686 --> 03:02:11,253 RDOC-BASED PARADIGMS TO ADDRESS 5347 03:02:11,320 --> 03:02:12,988 THE RELEVANT NEURAL CIRCUITS OF 5348 03:02:13,055 --> 03:02:14,023 COGNITIVE EFFECTIVE AND SOCIAL 5349 03:02:14,089 --> 03:02:16,592 DOMAINS AT HIGH SPATIAL AND 5350 03:02:16,659 --> 03:02:18,027 TEMPORAL PRECISION, AND NOVEL 5351 03:02:18,093 --> 03:02:20,729 TECHNOLOGICAL APPROACHES TO 5352 03:02:20,796 --> 03:02:22,331 NEURAL AND BEHAVIORAL RECORDING 5353 03:02:22,398 --> 03:02:23,632 AND STIMULATION THAT 5354 03:02:23,699 --> 03:02:24,500 INCORPORATES ARTIFICIAL 5355 03:02:24,566 --> 03:02:25,601 INTELLIGENCE AND MACHINE 5356 03:02:25,668 --> 03:02:27,236 LEARNING, NOVEL ELECTRODE AND 5357 03:02:27,303 --> 03:02:29,305 RECORDING DEVICES, VIRTUAL OR 5358 03:02:29,371 --> 03:02:31,273 AUGMENTED REALITY INTERFACES, 5359 03:02:31,340 --> 03:02:33,042 AND DIGITAL PHENOTYPING AND 5360 03:02:33,108 --> 03:02:34,743 DENSE BEHAVIORAL TRACKERS. 5361 03:02:34,810 --> 03:02:37,379 AND WITH THAT, I'D LIKE TO 5362 03:02:37,446 --> 03:02:40,449 INVITE DISCUSSION FROM DRS. 5363 03:02:40,516 --> 03:02:41,850 MACDONALD AND NIGG, I BELIEVE 5364 03:02:41,917 --> 03:02:52,227 WERE ON THIS ONE. 5365 03:02:55,064 --> 03:02:59,835 >> ARE YOU PRIEPED FOR PREPARER 5366 03:02:59,902 --> 03:03:00,803 NOT? 5367 03:03:00,869 --> 03:03:01,670 WE'LL LET JOEL START AND THAT 5368 03:03:01,737 --> 03:03:04,273 WILL GIVE YOU SOME MOMENTS TO 5369 03:03:04,340 --> 03:03:05,841 PREPARE. 5370 03:03:05,908 --> 03:03:07,142 DID ANYONE ELSE GET ASSIGNED 5371 03:03:07,209 --> 03:03:09,111 THIS ONE BY ANY CHANCE? 5372 03:03:09,178 --> 03:03:12,381 OKAY. 5373 03:03:12,448 --> 03:03:13,248 GO AHEAD, JOEL. 5374 03:03:13,315 --> 03:03:15,451 >> THAT'S A FANCY WAY TO GET OUT 5375 03:03:15,517 --> 03:03:18,854 OF GOING FIRST. 5376 03:03:18,921 --> 03:03:20,389 I WARNED TRACY THAT I'M GOING TO 5377 03:03:20,456 --> 03:03:22,191 GIVE A DECIDEDLY NON-EXPERT 5378 03:03:22,257 --> 03:03:22,991 COMMENT HERE. 5379 03:03:23,058 --> 03:03:23,992 THIS IS WELL OUTSIDE MY AREA OF 5380 03:03:24,059 --> 03:03:25,527 WORK. 5381 03:03:25,594 --> 03:03:26,829 BUT THAT SAID, THE POTENTIAL 5382 03:03:26,895 --> 03:03:31,533 THAT YOU HIGHLIGHTED IN YOUR 5383 03:03:31,600 --> 03:03:33,402 PRIOR -- SEEMED SO PROMISING 5384 03:03:33,469 --> 03:03:35,070 THAT WE ALMOST HAVE TO SUPPORT 5385 03:03:35,137 --> 03:03:37,339 THIS TYPE OF EFFORT. 5386 03:03:37,406 --> 03:03:39,007 I THINK IF I WAS TO SUGGEST 5387 03:03:39,074 --> 03:03:40,542 ANYTHING HERE, IT WOULD BE TO 5388 03:03:40,609 --> 03:03:42,745 EMPHASIZE EVEN MORE THAN YOU DO 5389 03:03:42,811 --> 03:03:44,847 THE IMPORTANCE OF STUDYING THE 5390 03:03:44,913 --> 03:03:46,915 VARIABILITY IN WHICH BEHAVIOR IS 5391 03:03:46,982 --> 03:03:49,418 IMPLEMENTED IN CIRCUITS IN 5392 03:03:49,485 --> 03:03:50,052 DIFFERENT CONTEXTS. 5393 03:03:50,119 --> 03:03:52,888 THERE'S A DANGER OF CREATING A 5394 03:03:52,955 --> 03:03:53,856 MACHINE-LIKE MODEL OF THE BRAIN 5395 03:03:53,922 --> 03:03:55,624 THAT MAY BE FAULTY, AND SO 5396 03:03:55,691 --> 03:03:56,892 ESSENTIALLY THE QUESTION IS, WHY 5397 03:03:56,959 --> 03:03:58,794 ARE THE EFFECTS VARIABLE? 5398 03:03:58,861 --> 03:04:00,295 WHY DID THE PRIOR PROMISE FAIL 5399 03:04:00,362 --> 03:04:03,265 IN A SENSE, YOU KNOW, THAT THAT 5400 03:04:03,332 --> 03:04:05,401 MAY BECOME A CENTRAL QUESTION 5401 03:04:05,467 --> 03:04:07,102 RATHER THAN NOISE IN THE SYSTEM, 5402 03:04:07,169 --> 03:04:08,604 THE VARIABILITY MAY BE LAWFUL. 5403 03:04:08,670 --> 03:04:11,740 AND SO I WOULD PUT MORE EMPHASIS 5404 03:04:11,807 --> 03:04:12,775 ON RECOGNIZING THAT THE SURGICAL 5405 03:04:12,841 --> 03:04:15,043 CONTEXT IS ONE CONTEXT, AND THEN 5406 03:04:15,110 --> 03:04:17,312 THE COMPLEX -- BEHAVIORAL 5407 03:04:17,379 --> 03:04:22,518 COMPLEX IS ANOTHER AND THE BRAIN 5408 03:04:22,584 --> 03:04:23,919 CAN -- THE SAME BEHAVIOR IN 5409 03:04:23,986 --> 03:04:24,486 DIFFERENT CIRCUITS. 5410 03:04:24,553 --> 03:04:26,088 SO TO HAVE THAT VARIABILITY 5411 03:04:26,155 --> 03:04:27,289 RESPONSE THAT YOU HEIGHT LIE 5412 03:04:27,356 --> 03:04:29,258 HERE, I'D PUT MORE EMPHASIS ON 5413 03:04:29,324 --> 03:04:31,360 THAT, WOULD BE MY ONLY 5414 03:04:31,427 --> 03:04:31,760 SUGGESTION. 5415 03:04:31,827 --> 03:04:33,862 I THINK OF THAT AS EENG LOGICAL 5416 03:04:33,929 --> 03:04:34,329 VALIDITY, IF YOU WILL. 5417 03:04:34,396 --> 03:04:35,931 >> I THINK IT'S ALSO REALLY 5418 03:04:35,998 --> 03:04:37,366 IMPORTANT FOR UNDERSTANDING 5419 03:04:37,433 --> 03:04:40,202 PRECISION MEDICINE APPROACHES, 5420 03:04:40,269 --> 03:04:41,470 BECAUSE WE'RE SEEING VARIABILITY 5421 03:04:41,537 --> 03:04:43,372 AT THE LEVEL OF INDIVIDUAL THAT 5422 03:04:43,439 --> 03:04:44,907 WE NEED TO UNDERSTAND IN ORDER 5423 03:04:44,973 --> 03:04:47,543 TO BUILD CLOSED LOOP MODELS THAT 5424 03:04:47,609 --> 03:04:50,179 CAN BE MORE WIDELY GENERALIZED. 5425 03:04:50,245 --> 03:04:53,315 >> THANK YOU FOR THAT 5426 03:04:53,382 --> 03:04:54,283 AMPLIFICATION. 5427 03:04:54,349 --> 03:04:57,052 AND I'LL ADD THE DEVELOPMENT, 5428 03:04:57,119 --> 03:04:58,387 ALL THE WAY UP TO THE THIRD 5429 03:04:58,454 --> 03:05:00,122 DECADE OF LIFE, SO HOW DOES 5430 03:05:00,189 --> 03:05:02,825 BRAIN MATURATION AND AGING 5431 03:05:02,891 --> 03:05:03,926 AFFECT IMPLEMENTATION? 5432 03:05:03,992 --> 03:05:06,528 OBVIOUSLY WITH THE TRANSCRANIAL 5433 03:05:06,595 --> 03:05:08,163 STIMULATIONS AND SO ON, WE HAVE 5434 03:05:08,230 --> 03:05:10,132 THE ISSUE OF WHAT HAPPENS IN 5435 03:05:10,199 --> 03:05:11,467 PEDIATRIC DEVELOPING BRAINS 5436 03:05:11,533 --> 03:05:13,802 BEING A CHALLENGE, SO I WOULD 5437 03:05:13,869 --> 03:05:15,237 ENCOURAGE A REFLECTION ON 5438 03:05:15,304 --> 03:05:16,872 DEVELOPMENT HERE TOO WITHOUT 5439 03:05:16,939 --> 03:05:18,173 MAKING THIS BE ALL THINGS TO ALL 5440 03:05:18,240 --> 03:05:20,008 PEOPLE TO STILL HAVE THAT AS 5441 03:05:20,075 --> 03:05:22,744 PART OF THE THOUGHT. 5442 03:05:22,811 --> 03:05:24,480 >> IF YOU ARE PREPARED TO MAKE A 5443 03:05:24,546 --> 03:05:25,013 COMMENT, YOU CAN. 5444 03:05:25,080 --> 03:05:27,416 NOW YOU CAN ALSO REVIEW THE 5445 03:05:27,483 --> 03:05:28,884 PROPOSAL AND GIVE US ADDITIONAL 5446 03:05:28,951 --> 03:05:29,151 COMMENTS. 5447 03:05:29,218 --> 03:05:31,620 >> WELL, I READ IT PREVIOUSLY, 5448 03:05:31,687 --> 03:05:35,390 SO I'M HAPPY TO COLLECT SOME OF 5449 03:05:35,457 --> 03:05:36,692 MY THOUGHTS. 5450 03:05:36,758 --> 03:05:40,863 THIS IS REALLY AN EXCITING AREA 5451 03:05:40,929 --> 03:05:42,598 FOR WHERE PSYCHOPATHOLOGY 5452 03:05:42,664 --> 03:05:44,500 RESEARCH IS GOING. 5453 03:05:44,566 --> 03:05:46,235 IN MY READING OF IT, I WAS 5454 03:05:46,301 --> 03:05:49,304 EXCITED, YOU KNOW, DEEP BRAIN 5455 03:05:49,371 --> 03:05:51,974 STIMULATION HAS HELD PROMISE FOR 5456 03:05:52,040 --> 03:05:54,343 SOME OF THE MOST INTRACTABLE 5457 03:05:54,409 --> 03:05:55,777 ASPECTS OF MENTAL ILLNESS OVER 5458 03:05:55,844 --> 03:05:58,447 THE PAST DECADE OR SO, AND IS 5459 03:05:58,514 --> 03:06:00,949 BECOMING INCREASINGLY USED IN A 5460 03:06:01,016 --> 03:06:05,354 NUMBER OF ADDITIONAL 5461 03:06:05,420 --> 03:06:07,089 CIRCUMSTANCES AND WHAT'S REALLY 5462 03:06:07,155 --> 03:06:09,057 BEEN INSPIRING THAT WILL I'VE 5463 03:06:09,124 --> 03:06:11,026 SEEN ACROSS A NUMBER OF 5464 03:06:11,093 --> 03:06:12,461 INSTITUTIONS IS HOW THIS 5465 03:06:12,528 --> 03:06:13,629 TECHNOLOGY HAS INCREASED 5466 03:06:13,695 --> 03:06:15,030 COMMUNICATION BETWEEN SURGERY 5467 03:06:15,097 --> 03:06:19,735 DEPARTMENTS AND PSYCHIATRY 5468 03:06:19,801 --> 03:06:21,270 DEPARTMENTS AND BRINGING IN 5469 03:06:21,336 --> 03:06:23,338 NEUROSCIENCE DEPARTMENTS AND SO 5470 03:06:23,405 --> 03:06:26,909 FORTH, SO I'M GLAD TO SEE THAT 5471 03:06:26,975 --> 03:06:28,143 THERE'S SUPPORT GOING ON HERE. 5472 03:06:28,210 --> 03:06:31,280 I'M WONDERING HOW NIMH IS 5473 03:06:31,346 --> 03:06:33,882 REACHING OUT TO PERHAPS SOME OF 5474 03:06:33,949 --> 03:06:36,718 THOSE OTHER INSTITUTES THAT 5475 03:06:36,785 --> 03:06:39,354 WOULD BE NATURAL ALLIES WITH 5476 03:06:39,421 --> 03:06:40,989 REGARDS TO THIS KIND OF WORK AS 5477 03:06:41,056 --> 03:06:42,357 IT'S GOING FORWARD. 5478 03:06:42,424 --> 03:06:44,826 >> YEAH, I LIKE THAT QUESTION 5479 03:06:44,893 --> 03:06:48,564 BECAUSE I THINK FOR A LOT OF 5480 03:06:48,630 --> 03:06:51,199 THESE PATIENT POPULATIONS, IT'S 5481 03:06:51,266 --> 03:06:53,168 A NATIONWIDE KIND OF RECRUITMENT 5482 03:06:53,235 --> 03:06:57,873 AREA, SO THERE ARE POCKETS OF 5483 03:06:57,940 --> 03:06:59,608 PEOPLE, RESEARCH TEAMS THAT ARE 5484 03:06:59,675 --> 03:07:01,043 IN THE UNITED STATES KIND OF 5485 03:07:01,109 --> 03:07:03,145 DOING THIS WORK, AND SO BY 5486 03:07:03,211 --> 03:07:04,446 NECESSITY, THEY NEED TO REACH 5487 03:07:04,513 --> 03:07:07,282 OUT TO EACH OTHER AND 5488 03:07:07,349 --> 03:07:08,917 INCORPORATE OTHER KIND OF 5489 03:07:08,984 --> 03:07:09,818 PERSPECTIVES. 5490 03:07:09,885 --> 03:07:13,221 SO I THINK THIS PARTICULAR 5491 03:07:13,288 --> 03:07:15,724 CONCEPT DOES FACILITATE ANY 5492 03:07:15,791 --> 03:07:16,658 INTERDISCIPLINARY SCIENCE KIND 5493 03:07:16,725 --> 03:07:21,163 OF AS YOU MENTIONED, BUT IT ALSO 5494 03:07:21,229 --> 03:07:22,264 NECESSITATES KIND OF 5495 03:07:22,331 --> 03:07:23,899 COMMUNICATION IN ORDER TO KIND 5496 03:07:23,966 --> 03:07:26,935 OF FACILITATE THE SCIENCE JUST 5497 03:07:27,002 --> 03:07:29,004 BECAUSE IT'S NOT UBIQUITOUS TO 5498 03:07:29,071 --> 03:07:30,005 EACH INSTITUTION. 5499 03:07:30,072 --> 03:07:31,540 SO I THINK THIS IS THE PERFECT 5500 03:07:31,607 --> 03:07:35,210 OPPORTUNITY FOR THAT. 5501 03:07:35,277 --> 03:07:36,044 >> THANK YOU. 5502 03:07:36,111 --> 03:07:37,279 ANY OTHER COMMENTS OR QUESTIONS? 5503 03:07:37,346 --> 03:07:39,581 TED. 5504 03:07:39,648 --> 03:07:40,349 >> THANK YOU. 5505 03:07:40,415 --> 03:07:41,917 I THINK THIS IS REALLY A 5506 03:07:41,984 --> 03:07:43,652 TERRIFIC OPPORTUNITY. 5507 03:07:43,719 --> 03:07:46,054 I THINK -- I WOULD ACTUALLY 5508 03:07:46,121 --> 03:07:48,023 THINK ABOUT PERHAPS WORDING IT 5509 03:07:48,090 --> 03:07:50,492 EVEN A LITTLE BIT BROADER. 5510 03:07:50,559 --> 03:07:51,526 ONE OF THE THINGS I GET A SENSE 5511 03:07:51,593 --> 03:07:53,161 OF, I HEAR THE DIALOGUE BETWEEN 5512 03:07:53,228 --> 03:07:56,331 PSYCHIATRISTS AND NEUROSURGEONS, 5513 03:07:56,398 --> 03:08:00,702 BUT NOT NECESSARILY THE CLINICAL 5514 03:08:00,769 --> 03:08:01,937 LEVEL, BECAUSE FOR EXAMPLE, 5515 03:08:02,004 --> 03:08:03,238 THERE ARE SOME LIMITATIONS TO 5516 03:08:03,305 --> 03:08:05,207 WHAT YOU CAN DO IN PATIENTS WHO 5517 03:08:05,273 --> 03:08:08,276 MAY NOT WANT TO BE DIAGNOSED 5518 03:08:08,343 --> 03:08:09,044 WITH SCHIZOPHRENIA OR IN 5519 03:08:09,111 --> 03:08:11,346 CHILDREN WITH AUTISM, SO YOU CAN 5520 03:08:11,413 --> 03:08:14,383 DO LIKE A SOCIAL RESPONSIVENESS 5521 03:08:14,449 --> 03:08:16,218 QUESTIONNAIRE, SEC, THERE ARE 5522 03:08:16,284 --> 03:08:19,121 THINGS CAN YOU DO, SO TO ME ONE 5523 03:08:19,187 --> 03:08:21,189 OF THE BIG QUESTIONS IS, HOW IS 5524 03:08:21,256 --> 03:08:25,527 WHAT YOU CAN UNDERSTAND IN A 5525 03:08:25,594 --> 03:08:26,795 NEUROSURGICAL SETTING, HOW DOES 5526 03:08:26,862 --> 03:08:27,663 THAT RELATE CLINICALLY? 5527 03:08:27,729 --> 03:08:28,597 I THINK THAT'S ONE OF THE 5528 03:08:28,664 --> 03:08:29,297 PIGGEST CHALLENGES. 5529 03:08:29,364 --> 03:08:34,302 BIGGEST CHALLENGES. 5530 03:08:34,369 --> 03:08:37,039 WE CAN UNDERSTAND HOW -- THERE'S 5531 03:08:37,105 --> 03:08:38,740 THIS GREAT EXPERIMENT NOW OF 5532 03:08:38,807 --> 03:08:40,308 LOOKING AT NAVIGATION IN 5533 03:08:40,375 --> 03:08:42,044 PATIENTS THAT ARE WALKING AROUND 5534 03:08:42,110 --> 03:08:44,246 WITH THE ELECTRODES IMPLANTED, 5535 03:08:44,312 --> 03:08:46,081 WHICH IS JUST REALLY INTERESTING 5536 03:08:46,148 --> 03:08:46,815 FROM A BASIC SCIENCE 5537 03:08:46,882 --> 03:08:47,315 PERSPECTIVE. 5538 03:08:47,382 --> 03:08:48,884 AND I WOULD REALLY THINK ABOUT 5539 03:08:48,950 --> 03:08:50,952 HOW IS IT YOU CAN ACTUALLY MAKE 5540 03:08:51,019 --> 03:08:53,789 A BETTER CONNECTION TO CLINICAL 5541 03:08:53,855 --> 03:08:55,123 AS BE SPECTS OF DISEASE AND 5542 03:08:55,190 --> 03:08:55,424 TREATMENT. 5543 03:08:55,490 --> 03:08:57,192 THIS IS STILL WORDED IN MANY 5544 03:08:57,259 --> 03:08:58,393 WAYS IN A BASIC WAY. 5545 03:08:58,460 --> 03:09:01,363 DOES THAT MAKE SENSE? 5546 03:09:01,430 --> 03:09:02,998 >> WE CAN THINK ABOUT THAT. 5547 03:09:03,065 --> 03:09:05,701 APPRECIATE THAT. 5548 03:09:05,767 --> 03:09:06,234 THANK YOU VERY MUCH. 5549 03:09:06,301 --> 03:09:08,003 APPRECIATE THE INPUT, AND WE'RE 5550 03:09:08,070 --> 03:09:09,337 GOING TO BRING UP OUR NEXT 5551 03:09:09,404 --> 03:09:12,507 PERSON AND WHILE DR. MIRI GITIK 5552 03:09:12,574 --> 03:09:14,743 COMES UP, I JUST WANT TO REMIND 5553 03:09:14,810 --> 03:09:16,912 ANY MEMBERS HERE FOR PUBLIC 5554 03:09:16,978 --> 03:09:18,213 COMMENT, WE KNOW WE'RE RUNNING 5555 03:09:18,280 --> 03:09:18,413 LATE. 5556 03:09:18,480 --> 03:09:19,347 WE'RE VERY SORRY. 5557 03:09:19,414 --> 03:09:20,248 MY GUESS IS WE'LL BE READY FOR 5558 03:09:20,315 --> 03:09:21,650 THE PUBLIC COMMENT AROUND 5559 03:09:21,717 --> 03:09:22,651 5:00 P.M., AND FOR THOSE MEMBERS 5560 03:09:22,718 --> 03:09:23,952 OF COUNCIL, IT MEANS WE ARE 5561 03:09:24,019 --> 03:09:25,921 GOING TO RUN A LITTLE BIT OVER. 5562 03:09:25,987 --> 03:09:28,156 I APOLOGIZE. 5563 03:09:28,223 --> 03:09:30,192 NEXT PRESENTER IS DR. MIRI GITIK 5564 03:09:30,258 --> 03:09:31,126 FROM THE DIVISION OF 5565 03:09:31,193 --> 03:09:32,360 NEUROSCIENCE AND BASIC 5566 03:09:32,427 --> 03:09:32,994 BEHAVIORAL SCIENCE. 5567 03:09:33,061 --> 03:09:34,362 SHE'S GOING TO PRESENT ON 5568 03:09:34,429 --> 03:09:35,964 GENETIC ARC AT THE TOUR OF 5569 03:09:36,031 --> 03:09:37,799 MENTAL DISORDERS IN ANCESTRALLY 5570 03:09:37,866 --> 03:09:40,235 DIVERSE POPULATIONS, THE SEQUEL. 5571 03:09:40,302 --> 03:09:41,870 >> THANK YOU. 5572 03:09:41,937 --> 03:09:43,071 GOOD AFTERNOON, AND THANK YOU 5573 03:09:43,138 --> 03:09:45,474 FOR THE OPPORTUNITY TO PRESENT 5574 03:09:45,540 --> 03:09:49,845 THIS NUMBER TWO CONCEPT. 5575 03:09:49,911 --> 03:09:52,881 SO BRIEFLY, TO DATE, MOST 5576 03:09:52,948 --> 03:09:54,316 PARTICIPANTS IN PSYCHIATRIC 5577 03:09:54,382 --> 03:09:57,119 GENETIC STUDIES ARE OF EUROPEAN 5578 03:09:57,185 --> 03:09:58,320 ANCESTRY AS YOU CAN SEE IN THE 5579 03:09:58,386 --> 03:10:03,125 FIGURE HERE. 5580 03:10:03,191 --> 03:10:06,228 [INAUDIBLE] RELATIVELY SMALL. 5581 03:10:06,294 --> 03:10:08,263 WHILE THIS FOCUS HAS LED TO 5582 03:10:08,330 --> 03:10:10,432 SUCCESSFUL GENETIC DISCOVERIES, 5583 03:10:10,499 --> 03:10:12,267 THE TRANSLATION OF THESE 5584 03:10:12,334 --> 03:10:13,602 FINDINGS TO -- REMAINS 5585 03:10:13,668 --> 03:10:16,938 PROBLEMATIC. 5586 03:10:17,005 --> 03:10:19,574 -- CREATES EVEN GREATER HEALTH 5587 03:10:19,641 --> 03:10:20,475 DISPARITIES. 5588 03:10:20,542 --> 03:10:23,078 TO ADDRESS THIS GAP, IN 2021, 5589 03:10:23,145 --> 03:10:27,616 NIMH HAS CREATED AN ANCESTRAL 5590 03:10:27,682 --> 03:10:28,984 POPULATIONS NETWORK, OR PAN, 5591 03:10:29,050 --> 03:10:37,058 WAPN WITHTHE IMPORTANT GOAL OF H 5592 03:10:37,125 --> 03:10:44,432 EQUITY, -- UNDERPOPULATIONS. 5593 03:10:44,499 --> 03:10:46,368 WITH OVER 100 INVESTIGATORS 5594 03:10:46,434 --> 03:10:49,070 WORKING OVER 25 SITES ACROSS THE 5595 03:10:49,137 --> 03:10:51,706 WORLD, AND FOCUSING ON 5596 03:10:51,773 --> 03:10:53,542 COLLECTING AND JOINTLY ANALYZING 5597 03:10:53,608 --> 03:10:55,744 DATA FROM OVER 200,000 5598 03:10:55,811 --> 03:10:56,378 PARTICIPANTS. 5599 03:10:56,444 --> 03:11:00,882 IN ADDITION TOLL THE FOCUS ON -- 5600 03:11:00,949 --> 03:11:02,484 HAS ALSO ESTABLISHED ANOTHER 5601 03:11:02,551 --> 03:11:06,321 SCIENTIFIC FOCUS WORKING GROUPS. 5602 03:11:06,388 --> 03:11:07,522 WHICH ARE TRYING TO ADDRESS THE 5603 03:11:07,589 --> 03:11:09,691 QUESTIONS OF RELEVANCE TO 5604 03:11:09,758 --> 03:11:12,961 NATIONAL STUDIES. 5605 03:11:13,028 --> 03:11:16,131 WE THEN CLOSE -- CLINICAL AND 5606 03:11:16,198 --> 03:11:17,532 COGNITIVE PHENOTYPES ACROSS 5607 03:11:17,599 --> 03:11:23,872 DIFFERENT SETTINGS WORLDWIDE. 5608 03:11:23,939 --> 03:11:25,707 -- GLOBAL HUMAN RESEARCH AND 5609 03:11:25,774 --> 03:11:29,110 ETHICAL QUESTIONS IN UNDERSERVED 5610 03:11:29,177 --> 03:11:31,346 POPULATIONS WORLDWIDE, AND 5611 03:11:31,413 --> 03:11:33,915 CAPACITY BUILDING, OR RESEARCH 5612 03:11:33,982 --> 03:11:35,550 CAPACITY BUILDING IN PSYCHIATRIC 5613 03:11:35,617 --> 03:11:36,751 GENETICS. 5614 03:11:36,818 --> 03:11:44,192 IN WORLD POPULATIONS. 5615 03:11:44,259 --> 03:11:46,027 THE SECOND PHASE AIMS TO EXPAND 5616 03:11:46,094 --> 03:11:47,128 THE PREVIOUS SUPPORTED EFFORTS 5617 03:11:47,195 --> 03:11:49,531 IN THE FIELD BY SUPPORTING 5618 03:11:49,598 --> 03:11:51,533 STUDIES THAT WILL COLLECT LARGER 5619 03:11:51,600 --> 03:11:54,169 SAMPLES TO PUSH GENETIC 5620 03:11:54,236 --> 03:11:58,440 DISCOVERY AND PROVIDE 5621 03:11:58,506 --> 03:12:00,742 INVESTIGATION, AND STUDIES THAT 5622 03:12:00,809 --> 03:12:06,081 AIM TO -- IN WHICH PHENOTYPIC 5623 03:12:06,147 --> 03:12:07,716 FOCUS. 5624 03:12:07,782 --> 03:12:08,817 IN ADDITION THIS EFFORT IS 5625 03:12:08,884 --> 03:12:11,086 FOCUSED ON GENERATING RESOURCES 5626 03:12:11,152 --> 03:12:12,821 FOR COMMUNITY. 5627 03:12:12,888 --> 03:12:17,525 AND THE IDEA HERE IS TO 5628 03:12:17,592 --> 03:12:21,263 EXPAND -- AT FERVOR, HARMONIZE 5629 03:12:21,329 --> 03:12:22,530 THE ANALYSIS BETWEEN THE 5630 03:12:22,597 --> 03:12:26,167 DIFFERENT PROJECTS. 5631 03:12:26,234 --> 03:12:27,235 BEST PRACTICES WITH SPECIFIC 5632 03:12:27,302 --> 03:12:29,738 FOCUS ON PSYCHIATRIC GENETICS IN 5633 03:12:29,804 --> 03:12:32,674 VULNERABLE POPULATIONS. 5634 03:12:32,741 --> 03:12:34,209 RESEARCH CAPACITY BUILDING 5635 03:12:34,276 --> 03:12:35,744 ACTIVITIES, AND DEVELOP 5636 03:12:35,810 --> 03:12:37,946 PRACTICES FOR HOW WE ENGAGE 5637 03:12:38,013 --> 03:12:42,617 SOCIAL DETERMINANTS OF HEALTH IN 5638 03:12:42,684 --> 03:12:43,919 GENETIC STUDIES AT THIS LARGE 5639 03:12:43,985 --> 03:12:44,152 SCALE. 5640 03:12:44,219 --> 03:12:45,253 THANK YOU VERY MUCH AND HAPPY TO 5641 03:12:45,320 --> 03:12:51,493 ANSWER YOUR QUESTIONS. 5642 03:12:51,559 --> 03:12:52,527 >> THANK YOU. 5643 03:12:52,594 --> 03:12:54,729 FOR DISCUSSANTS WE'VE ASKED 5644 03:12:54,796 --> 03:12:56,164 DR. SCOTT AND COLLINS TO COVER. 5645 03:12:56,231 --> 03:13:01,202 WHO WOULD LIKE TO START? 5646 03:13:01,269 --> 03:13:02,570 >> THANK YOU. 5647 03:13:02,637 --> 03:13:04,539 THANK YOU FOR THE PRESENTATION 5648 03:13:04,606 --> 03:13:08,376 AND IT WAS GREAT TO SEE 5649 03:13:08,443 --> 03:13:09,477 ELABORATE PIECE OF THE CONCEPT 5650 03:13:09,544 --> 03:13:10,679 BECAUSE SOME OF THE THINGS YOU 5651 03:13:10,745 --> 03:13:11,746 LISTED ARE THINGS I HAD 5652 03:13:11,813 --> 03:13:12,614 QUESTIONED ABOUT. 5653 03:13:12,681 --> 03:13:13,515 FIRST OF ALL I'M REALLY 5654 03:13:13,581 --> 03:13:14,616 SUPPORTIVE OF THIS CONCEPT. 5655 03:13:14,683 --> 03:13:19,654 IT REALLY IS FOUNDATIONAL GLOBAL 5656 03:13:19,721 --> 03:13:21,289 MENTAL HEALTH RESEARCH, BECAUSE 5657 03:13:21,356 --> 03:13:24,659 IT EXTENDS THE OPPORTUNITY TO 5658 03:13:24,726 --> 03:13:27,295 EXTEND RESEARCH TO SO MANY 5659 03:13:27,362 --> 03:13:27,929 POPULATIONS. 5660 03:13:27,996 --> 03:13:30,131 MY QUESTIONS WERE ABOUT THE 5661 03:13:30,198 --> 03:13:31,933 STRATEGIES OF ENSURING 5662 03:13:32,000 --> 03:13:32,434 GEOGRAPHIC DIVERSITY AND 5663 03:13:32,500 --> 03:13:33,201 THINKING ABOUT WOULD YOU 5664 03:13:33,268 --> 03:13:34,202 ACTUALLY BUILD ON THE CENTERS 5665 03:13:34,269 --> 03:13:35,971 THAT YOU ALREADY HAVE OR IS THIS 5666 03:13:36,037 --> 03:13:36,905 ACTUALLY AN OPPORTUNITY TO 5667 03:13:36,972 --> 03:13:38,473 FIGURE OUT STRATEGIES FOR THOSE 5668 03:13:38,540 --> 03:13:40,342 CENTERS TO STRENGTHEN NEW 5669 03:13:40,408 --> 03:13:41,876 CENTERS TO DO SOME OF THIS WORK 5670 03:13:41,943 --> 03:13:44,045 BECAUSE I THINK THAT'S CERTAIN 5671 03:13:44,112 --> 03:13:45,580 LITTLE AN OPPORTUNITY. 5672 03:13:45,647 --> 03:13:46,681 AND MY OTHER QUESTION WAS 5673 03:13:46,748 --> 03:13:50,819 ACTUALLY GOING TO BE ABOUT THE 5674 03:13:50,885 --> 03:13:52,053 LC COMPONENT BUT I CAN SEE YOU 5675 03:13:52,120 --> 03:13:54,322 ALREADY HAVE THE ETHICS WORKING 5676 03:13:54,389 --> 03:13:57,158 GROUPS AND THE SOARM 5677 03:13:57,225 --> 03:13:58,994 DETERMINANTS OF CAPACITY 5678 03:13:59,060 --> 03:14:00,028 BUILDING. 5679 03:14:00,095 --> 03:14:03,331 SO WHEN YOU BUILD OUT THE -- ARE 5680 03:14:03,398 --> 03:14:04,499 THOSE COMPONENTS ALSO FUNDED, I 5681 03:14:04,566 --> 03:14:06,935 GUESS IS ONE OF MY QUESTIONS? 5682 03:14:07,002 --> 03:14:07,902 IS IT -- 5683 03:14:07,969 --> 03:14:09,604 >> SO I GUESS TO ANSWER -- 5684 03:14:09,671 --> 03:14:15,810 >> WORK GROUPS, BUT ARE THERE 5685 03:14:15,877 --> 03:14:16,811 QUESTIONS AROUND THOSE AS WELL? 5686 03:14:16,878 --> 03:14:18,146 >> TO ANSWER YOUR FIRST 5687 03:14:18,213 --> 03:14:20,648 QUESTION, WE WOULD LIKE TO 5688 03:14:20,715 --> 03:14:22,617 DIVERSIFY OUR POOL GOING BACK 5689 03:14:22,684 --> 03:14:25,053 TO -- YOU CAN SEE WE HAVE A 5690 03:14:25,120 --> 03:14:25,720 PRETTY NICE DIVERSITY ALREADY 5691 03:14:25,787 --> 03:14:27,689 BUT WE REALLY WOULD LIKE TO 5692 03:14:27,756 --> 03:14:28,289 DIVERSIFY. 5693 03:14:28,356 --> 03:14:30,625 THIS WAS MENTIONED PREVIOUSLY IN 5694 03:14:30,692 --> 03:14:32,293 COUNCIL DISCUSSIONS. 5695 03:14:32,360 --> 03:14:36,431 WE DO NEED LARGER SAMPLES AND 5696 03:14:36,498 --> 03:14:37,098 MAKE SIGNIFICANT DISCOVERIES SO 5697 03:14:37,165 --> 03:14:38,666 WE WOULD LIKE TO SUPPORT THAT AS 5698 03:14:38,733 --> 03:14:40,201 WELL, AND THE QUESTION OF HOW 5699 03:14:40,268 --> 03:14:43,705 DEEP DO WE GO, BOTH IN GENOMIC 5700 03:14:43,772 --> 03:14:44,806 AND PHENOTYPE SPACE, SO WE WOULD 5701 03:14:44,873 --> 03:14:46,775 LIKE TO SUPPORT ALL OF THESE 5702 03:14:46,841 --> 03:14:47,308 GOING FORWARD. 5703 03:14:47,375 --> 03:14:49,944 TO ANSWER YOUR SECOND QUESTION 5704 03:14:50,011 --> 03:14:51,713 ETHICS AND COMMUNITY ENGAGEMENT, 5705 03:14:51,780 --> 03:14:53,214 WE WOMAN LIKE THESE TO BE BUILT 5706 03:14:53,281 --> 03:14:56,284 INTO THE APPLICATION SO THE 5707 03:14:56,351 --> 03:14:57,052 APPLICATION WILL HAVE ASPECTS OF 5708 03:14:57,118 --> 03:14:58,053 THAT BUILT INTO THE RESEARCH 5709 03:14:58,119 --> 03:15:03,458 DESIGN. 5710 03:15:03,525 --> 03:15:05,126 GENOMICS IS MOVING SLOWLY 5711 03:15:05,193 --> 03:15:05,794 TOWARDS THAT SO THIS WILL 5712 03:15:05,860 --> 03:15:07,962 PROBABLY BE ONE OF THE FIRST 5713 03:15:08,029 --> 03:15:09,631 COORDINATED EFFORTS TOWARDS 5714 03:15:09,697 --> 03:15:11,099 THAT, AND INVESTIGATORS WILL BE 5715 03:15:11,166 --> 03:15:12,167 TASKED TO THINK ABOUT HOW WE DO 5716 03:15:12,233 --> 03:15:14,002 THAT IN A GENETICS -- 5717 03:15:14,069 --> 03:15:14,903 >> THAT'S GREAT. 5718 03:15:14,969 --> 03:15:16,905 I REALLY LIKE THIS. 5719 03:15:16,971 --> 03:15:17,439 MY EXPERIENCE WITH THIS IS 5720 03:15:17,505 --> 03:15:19,174 THROUGH THE NEUROGAP INITIATIVE 5721 03:15:19,240 --> 03:15:20,408 THAT WILL DID A REALLY LOVELY 5722 03:15:20,475 --> 03:15:22,911 JOB OF INCORPORATING ETHICS AND 5723 03:15:22,977 --> 03:15:23,912 SOME OF THE SOCIAL IMPLICATION 5724 03:15:23,978 --> 03:15:26,748 OF THIS WORK AND THE -- IN SOME 5725 03:15:26,815 --> 03:15:28,316 OF THE AFRICAN SITES LISTED 5726 03:15:28,383 --> 03:15:30,985 THERE, SO BE GREAT TO SEE THAT 5727 03:15:31,052 --> 03:15:31,252 CONTINUE. 5728 03:15:31,319 --> 03:15:34,189 >> THANK YOU. 5729 03:15:34,255 --> 03:15:35,690 >> THANKS VERY MUCH FOR YOUR 5730 03:15:35,757 --> 03:15:36,124 PRESENTATION. 5731 03:15:36,191 --> 03:15:38,426 THAT WAS REALLY CLEAR. 5732 03:15:38,493 --> 03:15:42,697 SO I ALSO AGREE THAT THIS SHOULD 5733 03:15:42,764 --> 03:15:44,332 CONTINUE FOR A HOST OF REASONS. 5734 03:15:44,399 --> 03:15:46,134 THERE'S GREAT VALUE IN HAVING A 5735 03:15:46,201 --> 03:15:49,504 RANGE OF ANCESTRIES REPRESENTED 5736 03:15:49,571 --> 03:15:50,505 HERE. 5737 03:15:50,572 --> 03:15:52,540 I HAD A FEW RELATED QUESTIONS, 5738 03:15:52,607 --> 03:15:55,610 SO ONE THE SAME AS WE HAD BEF 5739 03:15:55,677 --> 03:15:58,213 BEFORE, ABOUT WHEN YOU CONTINUE 5740 03:15:58,279 --> 03:16:00,582 THE FUNDING, DO YOU ANTICIPATE 5741 03:16:00,648 --> 03:16:02,183 CONTINUING TO FUND THE SAME 5742 03:16:02,250 --> 03:16:04,352 PEOPLE THAT YOU HAVE BUT 5743 03:16:04,419 --> 03:16:07,388 EXPANDING THEIR STUDIES, MOST OF 5744 03:16:07,455 --> 03:16:08,690 THE PEOPLE OR ALL THE PEOPLE WHO 5745 03:16:08,756 --> 03:16:11,025 LEAD THOSE ARE VERY WELL 5746 03:16:11,092 --> 03:16:13,194 ESTABLISHED INVESTIGATORS. 5747 03:16:13,261 --> 03:16:14,395 ARE THERE PLANS TO ENCOURAGE 5748 03:16:14,462 --> 03:16:18,366 PEOPLE AT EARLIER STAIB STAGES N 5749 03:16:18,433 --> 03:16:20,001 THEIR CAREER TO LEAD THE WORK? 5750 03:16:20,068 --> 03:16:21,769 AND THEN ANOTHER ONE, THERE'S A 5751 03:16:21,836 --> 03:16:25,273 MIX OF ANCESTRIES REPRESENTED IN 5752 03:16:25,340 --> 03:16:27,142 THE -- I THINK IT'S SEVEN 5753 03:16:27,208 --> 03:16:29,244 STUDIES, HOWEVER MANY STUDIES 5754 03:16:29,310 --> 03:16:30,245 LISTED, LIKE THE PRESENTATION WE 5755 03:16:30,311 --> 03:16:33,414 HAD EARLIER ON EQUITY, I'M 5756 03:16:33,481 --> 03:16:34,516 CURIOUS ABOUT THE DIVERSITY IN 5757 03:16:34,582 --> 03:16:36,618 TERMS OF ANCESTRIES AND 5758 03:16:36,684 --> 03:16:40,355 BACKGROUNDS OF THE PEOPLE WURNT 5759 03:16:40,421 --> 03:16:43,258 CURRENTLY LEADING, MANAGING AND 5760 03:16:43,324 --> 03:16:44,626 ANALYZING THE DATA, AND HOW THAT 5761 03:16:44,692 --> 03:16:46,594 CAN BE EXPANDED OR WHAT PLANS 5762 03:16:46,661 --> 03:16:48,029 YOU MIGHT HAVE TO EXPAND THAT IN 5763 03:16:48,096 --> 03:16:50,298 THE NEXT ITERATION, AND THEN THE 5764 03:16:50,365 --> 03:16:52,133 THIRD THING IS ON DATA 5765 03:16:52,200 --> 03:16:52,467 DEPOSITION. 5766 03:16:52,534 --> 03:16:55,537 BECAUSE THAT REALLY ALLOWS A 5767 03:16:55,603 --> 03:16:58,473 MUCH BROADER GROUP OF PEOPLE TO 5768 03:16:58,540 --> 03:17:02,510 ASK QUESTIONS ABOUT THE DATA AND 5769 03:17:02,577 --> 03:17:05,180 YOU GET LARGER AND LARGER SAMPLE 5770 03:17:05,246 --> 03:17:06,281 SIZES WHICH ARE REALLY GOING TO 5771 03:17:06,347 --> 03:17:07,715 BE NECESSARY TO DO ANYTHING, SO 5772 03:17:07,782 --> 03:17:09,651 I'D BE CURIOUS ABOUT HOW MUCH OF 5773 03:17:09,717 --> 03:17:13,521 THE DATA HAS BEEN DEPOSITED, IF 5774 03:17:13,588 --> 03:17:15,723 YOU COULD HAVE A SCORECARD ON 5775 03:17:15,790 --> 03:17:20,061 THE WEBSITE THAT TELLS WHAT DATA 5776 03:17:20,128 --> 03:17:22,830 HAS BEEN DEPOSITED AND IN WHAT 5777 03:17:22,897 --> 03:17:26,134 FORM, THE GENOTYPES, THE 5778 03:17:26,201 --> 03:17:27,235 PHENOTYPE FILES THAT WOULD 5779 03:17:27,302 --> 03:17:28,770 EASILY FUNNEL SOMEBODY INTO 5780 03:17:28,836 --> 03:17:31,105 GOING TO FIND THIS, AND I 5781 03:17:31,172 --> 03:17:32,540 WONDERED ALSO IF YOU ARE GOING 5782 03:17:32,607 --> 03:17:35,743 TO FUND STUDIES THAT HAVE 5783 03:17:35,810 --> 03:17:36,711 ALREADY GOTTEN FUNDING, WHETHER 5784 03:17:36,778 --> 03:17:39,881 NEW FUNDING MIGHT BE CONTINGENT 5785 03:17:39,948 --> 03:17:43,184 ON DATA DEPOSITION FROM THE 5786 03:17:43,251 --> 03:17:45,520 FIRST ROUND OF FUNDING JUST TO 5787 03:17:45,587 --> 03:17:47,288 HELP PROVIDE ENCOURAGEMENT. 5788 03:17:47,355 --> 03:17:51,059 >> SO LAURA, I'M GOING TO ASK 5789 03:17:51,125 --> 03:17:54,829 TRACY WALDECK TO ANSWER YOUR 5790 03:17:54,896 --> 03:17:56,464 QUESTIONS BECAUSE THEY'RE REALLY 5791 03:17:56,531 --> 03:17:58,700 GRANTS POLICY QUESTIONS AS 5792 03:17:58,766 --> 03:17:59,567 OPPOSED TO PROGRAMMATIC 5793 03:17:59,634 --> 03:18:00,268 QUESTIONS. 5794 03:18:00,335 --> 03:18:00,468 TRACY. 5795 03:18:00,535 --> 03:18:01,669 >> SO JUST A COUPLE THINGS. 5796 03:18:01,736 --> 03:18:03,571 REMEMBER WE ARE DOING A CONCEPT 5797 03:18:03,638 --> 03:18:04,906 CLEARANCE OF THE SCIENCE, THE 5798 03:18:04,973 --> 03:18:06,307 AREA OF SCIENCE, WE'RE NOT 5799 03:18:06,374 --> 03:18:08,243 SPEAKING ABOUT FUNDING OR 5800 03:18:08,309 --> 03:18:11,613 APPLICATIONS, SO WE CAN'T WE 5801 03:18:11,679 --> 03:18:13,248 CAN'T SPEAK ABOUT WHO MIGHT BE 5802 03:18:13,314 --> 03:18:15,683 FUNDED OR WHO MIGHT APPLY. 5803 03:18:15,750 --> 03:18:16,484 SECONDLY, WE CANNOT TAKE INTO 5804 03:18:16,551 --> 03:18:18,119 ACCOUNT RACE, GENDER, ETHNICITY 5805 03:18:18,186 --> 03:18:20,555 IN TERMS OF WHO IS FUNDED, SO WE 5806 03:18:20,622 --> 03:18:21,456 DON'T HAVE THAT INFORMATION, WE 5807 03:18:21,522 --> 03:18:23,958 CAN'T SPEAK TO THAT INFORMATION 5808 03:18:24,025 --> 03:18:25,159 WHEN WE SELECT AN APPLICATION 5809 03:18:25,226 --> 03:18:27,262 FOR FUNDING SO WE WANT TO BE 5810 03:18:27,328 --> 03:18:27,929 REALLY CAREFUL ABOUT THAT. 5811 03:18:27,996 --> 03:18:31,399 IN TERMS OF DATA SHARING, NIH 5812 03:18:31,466 --> 03:18:33,301 HAS PRETTY CLEAR DATA SHARING 5813 03:18:33,368 --> 03:18:34,502 POLICIES SO THE DATA WILL BE 5814 03:18:34,569 --> 03:18:36,371 SHARED, THEY HAVE TO SUBMIT A 5815 03:18:36,437 --> 03:18:37,639 DATA SHARING AND MANAGEMENT 5816 03:18:37,705 --> 03:18:38,373 PLAN. 5817 03:18:38,439 --> 03:18:39,607 IN TERMS OF HOW IT'S REPRESENTED 5818 03:18:39,674 --> 03:18:41,075 ON THE NIMH WEBSITE, I THINK THE 5819 03:18:41,142 --> 03:18:44,245 TEAM CAN CERTAINLY TAKE YOUR 5820 03:18:44,312 --> 03:18:44,846 SUGGESTIONS INTO CONSIDERATION 5821 03:18:44,912 --> 03:18:46,447 FOR FUTURE POSTING. 5822 03:18:46,514 --> 03:18:47,115 >> THANKS. 5823 03:18:47,181 --> 03:18:48,683 >> THANK YOU, LAURA. 5824 03:18:48,750 --> 03:18:51,252 AND THANK YOU, MARIE. 5825 03:18:51,319 --> 03:18:51,886 ANY OTHER COMMENTS OR QUESTIONS 5826 03:18:51,953 --> 03:18:54,889 BEFORE HE WITH MOVE ON? 5827 03:18:54,956 --> 03:18:56,758 WE MOVE ON? 5828 03:18:56,824 --> 03:18:58,993 PLEASE, JYOTI. 5829 03:18:59,060 --> 03:19:01,162 >> AS YOU THINK ABOUT PHASE TWO, 5830 03:19:01,229 --> 03:19:02,463 ARE THERE OPPORTUNITIES TO 5831 03:19:02,530 --> 03:19:05,700 POTENTIAL PARTNER WITH FOGARTY? 5832 03:19:05,767 --> 03:19:06,334 >> YES. 5833 03:19:06,401 --> 03:19:06,501 YES. 5834 03:19:06,567 --> 03:19:07,101 >> THAT'S ALL. 5835 03:19:07,168 --> 03:19:07,735 THANK YOU. 5836 03:19:07,802 --> 03:19:10,138 >> OKAY. 5837 03:19:10,204 --> 03:19:11,639 THE FINAL CONCEPT CLEARANCE WILL 5838 03:19:11,706 --> 03:19:21,816 BE PRESENTED BY DR. YAEL 5839 03:19:21,883 --> 03:19:24,552 MANDELBLAT-CERF, NATIONAL 5840 03:19:24,619 --> 03:19:25,753 COOPERATIVE DRUG DISE VICE 5841 03:19:25,820 --> 03:19:29,023 DISCOVERY DEVELOPMENT GROUPS FOR 5842 03:19:29,090 --> 03:19:30,325 THE TREATMENT OF MENTAL 5843 03:19:30,391 --> 03:19:40,568 DISORDERS. 5844 03:19:49,877 --> 03:20:00,154 >> HELLO, EVERYONE. 5845 03:20:01,222 --> 03:20:04,492 THE DIVISION OF NEUROSCIENCE AND 5846 03:20:04,559 --> 03:20:05,927 BASIC BEHAVIOR SCIENCE IN THE 5847 03:20:05,993 --> 03:20:06,561 DIVISION OF TRANSLATIONAL 5848 03:20:06,627 --> 03:20:13,468 RESEARCH. 5849 03:20:13,534 --> 03:20:14,769 SO THERAPEUTICS DEVELOPMENT IS 5850 03:20:14,836 --> 03:20:15,703 HARD. 5851 03:20:15,770 --> 03:20:17,972 WE ALL KNOW. 5852 03:20:18,039 --> 03:20:20,708 IT'S LONG RISKY AND HIGHLY 5853 03:20:20,775 --> 03:20:21,809 EXPENSIVE PROCESS. 5854 03:20:21,876 --> 03:20:24,512 IT TAKES BETWEEN 10 TO 15 YEARS 5855 03:20:24,579 --> 03:20:25,646 TO BRING A NEW DRUG TO THE 5856 03:20:25,713 --> 03:20:28,816 MARKET, AND IT COSTS BETWEEN 5857 03:20:28,883 --> 03:20:31,419 1 TO 2 BI BILLION DOLLARS. 5858 03:20:31,486 --> 03:20:33,154 THE PROCESS INCLUDES MULTIPLE 5859 03:20:33,221 --> 03:20:35,256 STEPS ALL AIMED AND DE-RISKING 5860 03:20:35,323 --> 03:20:37,658 THE THERAPEUTICS DEVELOPMENT AND 5861 03:20:37,725 --> 03:20:39,193 INCREASING THE PROBABILITY OF 5862 03:20:39,260 --> 03:20:39,761 SUCCESS. 5863 03:20:39,827 --> 03:20:42,930 THAT INCLUDES TARGET 5864 03:20:42,997 --> 03:20:45,400 AUTHENTIFICATION AND VALIDATION, 5865 03:20:45,466 --> 03:20:47,101 COMPOUND SCREENING LIKE 5866 03:20:47,168 --> 03:20:49,670 HIGH-THROUGHPUT SCREENING, 5867 03:20:49,737 --> 03:20:54,709 OPTIMIZATION OF PROPERTIES AND 5868 03:20:54,776 --> 03:20:56,978 ACTIVITY, PRE-CLINICAL TESTING, 5869 03:20:57,044 --> 03:20:59,046 BIOMARKER DEVELOPMENT, AND OF 5870 03:20:59,113 --> 03:21:01,983 COURSE EVENTUALLY OPTIMAL DESIGN 5871 03:21:02,049 --> 03:21:03,751 OF CLINICAL TRIAL. 5872 03:21:03,818 --> 03:21:05,920 STILL WITH ALL THESE EFFORTS, 5873 03:21:05,987 --> 03:21:07,789 EVENTUALLY FOR THOSE COMPOUNDS 5874 03:21:07,855 --> 03:21:08,990 THAT SUCCEED TO GET TO THE 5875 03:21:09,056 --> 03:21:13,461 CLINICAL PHASE, 90% OF THEM FAIL 5876 03:21:13,528 --> 03:21:16,030 BETWEEN PHASE ONE TO PHASE THREE 5877 03:21:16,097 --> 03:21:18,332 AND LEAVING PATIENTS EAGERLY 5878 03:21:18,399 --> 03:21:19,767 AWAITING FOR EFFECTIVE 5879 03:21:19,834 --> 03:21:20,201 THERAPEUTICS. 5880 03:21:20,268 --> 03:21:24,405 SO FOR THIS CONCEPT, THE AIM IS 5881 03:21:24,472 --> 03:21:28,676 TO ACCELERATE THE INNOVATIVE -- 5882 03:21:28,743 --> 03:21:30,178 FROM DISCOVERY AND PRE-CLINICAL 5883 03:21:30,244 --> 03:21:33,581 DEVELOPMENT UNTIL THE CLINICAL 5884 03:21:33,648 --> 03:21:35,016 EARLY TRIALS FOR NEW CANDIDATES 5885 03:21:35,082 --> 03:21:43,424 TO TREAT MENTAL DISORDERS. 5886 03:21:43,491 --> 03:21:44,759 THE 5887 03:21:44,826 --> 03:21:46,160 INITIATIVE GOALS, ADVANCE THE 5888 03:21:46,227 --> 03:21:48,029 DISCOVERY, DEVELOPMENT AND PLOOF 5889 03:21:48,095 --> 03:21:50,531 OF CONCEPT TESTING OF NEW 5890 03:21:50,598 --> 03:21:51,566 EVIDENCE-BASED CANDIDATE AGENTS 5891 03:21:51,632 --> 03:21:52,333 AND NEUROSTIMULATION APPROACHES 5892 03:21:52,400 --> 03:21:54,502 TO TREAT MENTAL DISORDERS, TO 5893 03:21:54,569 --> 03:21:56,938 DEVELOP PHARMACOLOGIC AND 5894 03:21:57,004 --> 03:21:57,805 NEUROMODULATORY TOOLS FOR BASIC 5895 03:21:57,872 --> 03:21:59,807 AND CLINICAL RESEARCH IN SUPPORT 5896 03:21:59,874 --> 03:22:01,809 OF EXPERIMENTAL THERAPEUTIC 5897 03:22:01,876 --> 03:22:02,043 STUDIES. 5898 03:22:02,109 --> 03:22:03,144 TO FOSTER COLLABORATIVE 5899 03:22:03,211 --> 03:22:04,212 PARTNERSHIPS BETWEEN ACADEMIC 5900 03:22:04,278 --> 03:22:05,980 AND INDUSTRY RESEARCHERS AND 5901 03:22:06,047 --> 03:22:07,148 MULTIDISCIPLINARY TEAMS OF 5902 03:22:07,215 --> 03:22:15,957 SCIENTISTS. 5903 03:22:16,023 --> 03:22:17,592 WE EXPECT TO GENERATE PROJECTS 5904 03:22:17,658 --> 03:22:20,661 THAT PROPOSE TRANSLATABLE NEW 5905 03:22:20,728 --> 03:22:21,696 THERAPEUTICS ACROSS DIFFERENT 5906 03:22:21,762 --> 03:22:21,996 MODALITIES. 5907 03:22:22,063 --> 03:22:25,500 WHETHAT CAN BE SMALL MOLECULES, 5908 03:22:25,566 --> 03:22:27,134 ASO, GENE THERAPY, AND ALSO 5909 03:22:27,201 --> 03:22:28,236 NOVEL NEUROSTIMULATION 5910 03:22:28,302 --> 03:22:30,204 TECHNOLOGIES INCLUDING FOR 5911 03:22:30,271 --> 03:22:31,973 EXAMPLE CLOSED LOOP STIMULATIONS 5912 03:22:32,039 --> 03:22:33,074 THAT WAS MENTIONED BEFORE AS 5913 03:22:33,140 --> 03:22:33,441 WELL. 5914 03:22:33,508 --> 03:22:35,610 WE ALSO EXPECT TO GENERATE 5915 03:22:35,676 --> 03:22:39,413 PROJECTS THAT PROPOSE NOVEL 5916 03:22:39,480 --> 03:22:41,082 PHARMACOLOGIC RESEARCH TOOLS FOR 5917 03:22:41,148 --> 03:22:42,283 BASIC AND CLINICAL RESEARCH TO 5918 03:22:42,350 --> 03:22:44,018 FURTHER CHARACTERIZE EXISTING 5919 03:22:44,085 --> 03:22:45,453 DRUG TARGETS OR TO VALIDATE NEW 5920 03:22:45,520 --> 03:22:47,388 ONES. 5921 03:22:47,455 --> 03:22:49,123 NEW CLINICAL MEASURES OR 5922 03:22:49,190 --> 03:22:50,858 BIOMARKERS FOR HUMAN PROOF OF 5923 03:22:50,925 --> 03:22:53,594 CONCEPT TRIALS OR NEW NOVEL 5924 03:22:53,661 --> 03:22:55,429 THERAPEUTICS FOR MENTAL HEALTH 5925 03:22:55,496 --> 03:22:56,097 DISORDERS. 5926 03:22:56,163 --> 03:22:57,632 ASSESS THE SAFETY, TOLERABILITY 5927 03:22:57,698 --> 03:23:00,601 AND EFFICACY FOR PROMISING NOVEL 5928 03:23:00,668 --> 03:23:02,803 THERAPEUTIC DRUGS AND DEVICES IN 5929 03:23:02,870 --> 03:23:07,308 EARLY CLINICAL TRIALS. 5930 03:23:07,375 --> 03:23:07,608 THAT'S ALL. 5931 03:23:07,675 --> 03:23:08,843 THANK YOU FOR LISTENING. 5932 03:23:08,910 --> 03:23:09,510 >> THANK YOU. 5933 03:23:09,577 --> 03:23:11,779 AND FOR OUR DISCUSSANTS, WE'VE 5934 03:23:11,846 --> 03:23:13,614 ASKED DRS. ABEL AND MACDONALD TO 5935 03:23:13,681 --> 03:23:14,615 COMMENT. 5936 03:23:14,682 --> 03:23:18,719 WHO'S GOING TO START? 5937 03:23:18,786 --> 03:23:20,154 >> I'M HAPPY TO GO. 5938 03:23:20,221 --> 03:23:22,089 >> I GOT A PASS LAST TIME. 5939 03:23:22,156 --> 03:23:23,324 >> GO AHEAD. 5940 03:23:23,391 --> 03:23:28,796 >> I'LL JUMP IN THIS TIME. 5941 03:23:28,863 --> 03:23:32,934 SO THIS IS HEADY STUFF, HOW DO 5942 03:23:33,000 --> 03:23:37,805 WE GET THE THERAPEUTICS PIPELINE 5943 03:23:37,872 --> 03:23:38,105 GOING. 5944 03:23:38,172 --> 03:23:40,508 I THINK A LOT OF US WILL FIND 5945 03:23:40,575 --> 03:23:41,609 THAT THERE'S AN ECHO BETWEEN 5946 03:23:41,676 --> 03:23:43,377 THIS AND THE FIRST CONCEPT 5947 03:23:43,444 --> 03:23:46,180 CLEARANCE. 5948 03:23:46,247 --> 03:23:53,821 SO MY FIRST COMMENT WAS IS THIS 5949 03:23:53,888 --> 03:23:57,224 AN OVERLAPPING VENN DIAGRAM IN 5950 03:23:57,291 --> 03:24:00,461 TERMS OF THE STIMULATION 5951 03:24:00,528 --> 03:24:00,695 DEVICES? 5952 03:24:00,761 --> 03:24:01,429 THIS OF COURSE ALSO INCLUDES 5953 03:24:01,495 --> 03:24:02,997 OTHER KINDS OF NEUROTHERAPEUTICS 5954 03:24:03,064 --> 03:24:06,300 AS WELL, BUT ARE THERE 5955 03:24:06,367 --> 03:24:07,368 CONVERSATIONS THERE THAT WOULD 5956 03:24:07,435 --> 03:24:10,805 BE USEFUL TO HAVE SO THAT YOU 5957 03:24:10,871 --> 03:24:13,975 GUYS CAN EITHER BE SURE TO KEEP 5958 03:24:14,041 --> 03:24:17,612 THESE CONCEPTS SEPARATE OR MERGE 5959 03:24:17,678 --> 03:24:25,653 THEM AS MAY BE APPROPRIATE? 5960 03:24:25,720 --> 03:24:27,254 AND I THINK ANOTHER ASPECT OF 5961 03:24:27,321 --> 03:24:30,658 THIS IS THAT THIS IS -- THIS 5962 03:24:30,725 --> 03:24:35,963 ALSO HAS AN HE C AN ECHO TO THET 5963 03:24:36,030 --> 03:24:38,265 CAME OUT IN 2022, WAS IT, A FEW 5964 03:24:38,332 --> 03:24:41,669 YEARS BACK THAT WAS THIS PLUS 5965 03:24:41,736 --> 03:24:44,605 ALCOHOL, AND NOW ALCOHOL, YOU 5966 03:24:44,672 --> 03:24:47,441 GUYS -- THERE ARE FOLKS FOR 5967 03:24:47,508 --> 03:24:50,378 THAT, SO IT SEEMS LIKE THERE 5968 03:24:50,444 --> 03:24:51,512 WOULD BE A TRACK RECORD FOR THIS 5969 03:24:51,579 --> 03:24:54,515 KIND OF PRIMING OF THE PUMP, AND 5970 03:24:54,582 --> 03:24:58,352 IT WOULD BE USEFUL TO -- I WAS 5971 03:24:58,419 --> 03:24:58,986 WONDERING WHAT HAD BEEN LEARNED 5972 03:24:59,053 --> 03:24:59,854 FROM THAT PROCESS. 5973 03:24:59,920 --> 03:25:02,156 FOR EXAMPLE, ARE THERE WAYS IN 5974 03:25:02,223 --> 03:25:04,992 WHICH THE FDA HAS BROUGHT IN TO 5975 03:25:05,059 --> 03:25:06,627 SOME PROJECTS VERSUS OTHER 5976 03:25:06,694 --> 03:25:09,363 PROJECTS OR HAS BEEN BROUGHT 5977 03:25:09,430 --> 03:25:10,998 IN -- THAT CAN BE BROUGHT IN 5978 03:25:11,065 --> 03:25:12,433 EARLY TO REDUCE REDUNDANT 5979 03:25:12,500 --> 03:25:17,271 EFFORT, TO REDUCE TO STREAMLINE 5980 03:25:17,338 --> 03:25:19,874 THAT INTEGRATION BECAUSE THESE 5981 03:25:19,940 --> 03:25:22,943 ARE ULTIMATELY CONVERSATIONS 5982 03:25:23,010 --> 03:25:27,615 THAT WILL COME BEFORE THE FDA. 5983 03:25:27,682 --> 03:25:30,818 SO THAT WAS THE SECOND QUESTION 5984 03:25:30,885 --> 03:25:31,352 I HAD. 5985 03:25:31,419 --> 03:25:36,991 AND THEN I ALSO WANTED TO 5986 03:25:37,058 --> 03:25:40,027 CHANNEL DR. BEIDAS A LITTLE BIT, 5987 03:25:40,094 --> 03:25:41,662 RINAD WOULD PROBABLY ASK YOU IS 5988 03:25:41,729 --> 03:25:44,432 THERE A WAY TO -- ABOUT 5989 03:25:44,498 --> 03:25:45,533 SCALABILITY, ABOUT 5990 03:25:45,599 --> 03:25:46,400 IMPLEMENTABILITY INTO THESE 5991 03:25:46,467 --> 03:25:50,337 APPLICATIONS SO THAT WE CAN BE 5992 03:25:50,404 --> 03:25:55,476 ASKING INVESTIGATORS BEFOREHAND, 5993 03:25:55,543 --> 03:25:56,477 WHAT DO THINGS LOOK LIKE GOING 5994 03:25:56,544 --> 03:25:58,245 FORWARD IN TERMS OF THE 5995 03:25:58,312 --> 03:26:01,615 IMPLEMENTABILITY OF THESE? 5996 03:26:01,682 --> 03:26:03,417 TWO COMPOUNDS THAT ARE OTHERWISE 5997 03:26:03,484 --> 03:26:03,951 INDISTINGUISHABLE, THE ONE 5998 03:26:04,018 --> 03:26:07,121 THAT'S MORE IMPLEMENTABLE IS THE 5999 03:26:07,188 --> 03:26:09,957 ONE THAT WE'RE GOING TO WANT TO 6000 03:26:10,024 --> 03:26:10,958 PUT MORE BEHIND. 6001 03:26:11,025 --> 03:26:12,727 AND THOSE ARE MY THREE THOUGHTS. 6002 03:26:12,793 --> 03:26:15,096 >> OKAY. 6003 03:26:15,162 --> 03:26:16,263 SO WHILE START WITH THE FIRST 6004 03:26:16,330 --> 03:26:16,964 ONE. 6005 03:26:17,031 --> 03:26:18,466 THE BIG DIFFERENCE IS THAT IN 6006 03:26:18,532 --> 03:26:20,167 THIS PROCESS, IN THIS CONCEPT, 6007 03:26:20,234 --> 03:26:23,471 WE ARE FOCUSING FROM THE EARLY 6008 03:26:23,537 --> 03:26:26,407 DEVELOPMENT OF DRUG/DEVICE AND 6009 03:26:26,474 --> 03:26:27,708 TAKING IT ALL THE WAY TO THE 6010 03:26:27,775 --> 03:26:31,145 FIRST IN HUMAN, WHILE TO MY 6011 03:26:31,212 --> 03:26:33,114 UNDERSTANDING, THE OTHER CONCEPT 6012 03:26:33,180 --> 03:26:35,683 WAR MORE ABOUT EXISTING DEVICES 6013 03:26:35,750 --> 03:26:37,184 AND OPTIMIZING THEM AND MAYBE 6014 03:26:37,251 --> 03:26:40,154 THOSE THAT ARE MORE LATE TO THE 6015 03:26:40,221 --> 03:26:41,922 DEVELOPMENT, SO IN THAT SENSE I 6016 03:26:41,989 --> 03:26:43,457 SEE THAT DOES NOT OVERLAP, BUT 6017 03:26:43,524 --> 03:26:47,595 WE CAN DEFINITELY MAKE SURE THAT 6018 03:26:47,661 --> 03:26:50,131 IT'S DEFINITELY SEPARATED. 6019 03:26:50,197 --> 03:26:53,234 THE SECOND QUESTION ABOUT THE -- 6020 03:26:53,300 --> 03:26:54,635 FROM TWO YEARS AGO, YES, IT IS A 6021 03:26:54,702 --> 03:26:58,239 CONTINUATION OF THAT, THEY 6022 03:26:58,305 --> 03:27:00,941 DECIDED NOT TO JOIN THIS NEW 6023 03:27:01,008 --> 03:27:02,376 CONCEPT. 6024 03:27:02,443 --> 03:27:04,478 AND LACKING BACK FOR THE LAST 10 6025 03:27:04,545 --> 03:27:07,348 YEARS, THERE WERE OVER 10 6026 03:27:07,414 --> 03:27:14,021 PROJECTS THAT WE AWARDED IN THIS 6027 03:27:14,088 --> 03:27:15,089 CONCEPT, DIFFERENT DEVELOPMENTS 6028 03:27:15,156 --> 03:27:20,461 OF IT, AND YES, IT'S HARD TO 6029 03:27:20,528 --> 03:27:21,896 FIND THOSE PROJECTS, IT'S HARD 6030 03:27:21,962 --> 03:27:23,130 TO GET THEM AND IT'S NOT -- I 6031 03:27:23,197 --> 03:27:28,169 WISH THERE WERE MORE -- A REASON 6032 03:27:28,235 --> 03:27:31,472 TO CONTINUE IT AND MAYBE GET 6033 03:27:31,539 --> 03:27:34,208 MORE, THINKING OTHER WAYS HOW TO 6034 03:27:34,275 --> 03:27:38,979 ENGAGE SI SCIENTISTS TO ATTRACT 6035 03:27:39,046 --> 03:27:40,281 THEM AND DEVELOP THOSE PROJECT, 6036 03:27:40,347 --> 03:27:42,316 BUT IN THAT SENSE, I'M NOT SURE 6037 03:27:42,383 --> 03:27:44,285 WHAT ELSE I'M -- 6038 03:27:44,351 --> 03:27:47,221 >> THE QUESTION, IF YOU'VE GOT A 6039 03:27:47,288 --> 03:27:48,088 POPULATION OF 10 STUDIES, WHICH 6040 03:27:48,155 --> 03:27:49,657 OF THOSE WERE SUCCESSFUL, WHICH 6041 03:27:49,723 --> 03:27:51,225 OF THOSE WEREN'T SUCCESSFUL, ARE 6042 03:27:51,292 --> 03:27:52,860 THERE LESSONS TO BE LEARNED FROM 6043 03:27:52,927 --> 03:27:53,928 THOSE SUCCESSES AND NOT 6044 03:27:53,994 --> 03:27:54,895 SUCCESSES, AND ALSO 6045 03:27:54,962 --> 03:27:56,096 CONSULTATIONS TO BE HAD WITH 6046 03:27:56,163 --> 03:27:58,065 PERHAPS SOME OF BOTH THE 6047 03:27:58,132 --> 03:28:00,434 SUCCESSFUL APPLICANTS AND THE 6048 03:28:00,501 --> 03:28:03,037 UNSUCCESSFUL APPLICANTS AS TO 6049 03:28:03,103 --> 03:28:08,275 HOW THAT RFA COULD BE TWEAKED 6050 03:28:08,342 --> 03:28:10,477 FURTHER TO OPTIMIZE IT FOR THEIR 6051 03:28:10,544 --> 03:28:18,219 CIRCUMSTANCES. 6052 03:28:18,285 --> 03:28:20,588 >> LINDA, IF YOU WANT TO CHIME 6053 03:28:20,654 --> 03:28:20,754 IN? 6054 03:28:20,821 --> 03:28:23,090 >> I THINK WE'LL MOVE TO TED'S 6055 03:28:23,157 --> 03:28:23,357 QUESTION. 6056 03:28:23,424 --> 03:28:24,692 >> THANK YOU. 6057 03:28:24,758 --> 03:28:26,861 FIRST A COMMENT, I THINK THIS IS 6058 03:28:26,927 --> 03:28:28,195 REALLY TERRIFIC AND I THINK IT 6059 03:28:28,262 --> 03:28:30,664 BUILDS ON A LOT OF THE FOCUS ON 6060 03:28:30,731 --> 03:28:32,766 PRECISION PSYCHIATRY AND 6061 03:28:32,833 --> 03:28:33,968 UNDERSTANDING TARGET ENGAGEMENT, 6062 03:28:34,034 --> 03:28:36,837 AND IT REQUIRES A LOT OF THESE 6063 03:28:36,904 --> 03:28:37,838 TESTS, WHICH IS MAYBE WHY 6064 03:28:37,905 --> 03:28:38,939 THERE'S SO FEW OF THEM, BECAUSE 6065 03:28:39,006 --> 03:28:40,007 YOU REALLY NEED TO HAVE 6066 03:28:40,074 --> 03:28:41,575 SOMETHING YOU ACTUALLY KNOW WHAT 6067 03:28:41,642 --> 03:28:43,811 IT'S GOING TO DO AND BE ABLE TO 6068 03:28:43,878 --> 03:28:45,246 FOLLOW IT, WHICH IS A PRETTY 6069 03:28:45,312 --> 03:28:45,880 HIGH BAR. 6070 03:28:45,946 --> 03:28:47,248 THE OTHER BAR IS A BAR THAT 6071 03:28:47,314 --> 03:28:48,449 COMPANIES MAY SET, WHERE THEY 6072 03:28:48,515 --> 03:28:50,985 MAY NOT WANT TO HAVE COMPOUNDS 6073 03:28:51,051 --> 03:28:52,486 TESTED IN THIS WAY, SO THAT'S 6074 03:28:52,553 --> 03:28:54,655 SOMETHING TO CONSIDER ABOUT 6075 03:28:54,722 --> 03:28:55,823 WHAT'S GOING TO BE KIND OF 6076 03:28:55,890 --> 03:28:58,025 ALLOWED AND WHAT'S GOING TO 6077 03:28:58,092 --> 03:28:59,560 HAPPEN. 6078 03:28:59,627 --> 03:29:00,928 I ALSO THINK ONCE YOU CONSIDER 6079 03:29:00,995 --> 03:29:01,862 THE FOLLOW YUN OF INDIVIDUALS IN 6080 03:29:01,929 --> 03:29:03,063 THESE STUDY, GRANTS THAT ARE 6081 03:29:03,130 --> 03:29:05,099 GOING TO BE FUNDED BY NIH ARE 6082 03:29:05,165 --> 03:29:06,133 GOING TO HAVE A DURATION BUT 6083 03:29:06,200 --> 03:29:07,001 THESE INDIVIDUALS HAVE A 6084 03:29:07,067 --> 03:29:09,203 LIFETIME THAT THEY LIVE. 6085 03:29:09,270 --> 03:29:11,105 AND IT WOULD BE IMPORTANT, I 6086 03:29:11,171 --> 03:29:11,772 THINK, TO HAVE SOME WAY TO KEEP 6087 03:29:11,839 --> 03:29:12,239 TRACK OF THEM. 6088 03:29:12,306 --> 03:29:13,874 IT'S A LITTLE BIT ABOUT WHAT 6089 03:29:13,941 --> 03:29:18,479 ANGUS WAS SAYING, WHAT WOULD 6090 03:29:18,545 --> 03:29:19,480 HAPPEN WITH THESE STUDIES. 6091 03:29:19,546 --> 03:29:20,581 HAVE YOU THOUGHT ABOUT HOW 6092 03:29:20,648 --> 03:29:23,984 ETHICAL CONCERNS WILL BE 6093 03:29:24,051 --> 03:29:28,155 INCORPORATED INTO THIS CONCEPT 6094 03:29:28,222 --> 03:29:32,660 CLEARANCE AND INTO THIS PROGRAM? 6095 03:29:32,726 --> 03:29:34,061 >> I HAVE NOT. 6096 03:29:34,128 --> 03:29:35,396 FROM MY POINT OF VIEW, MOST OF 6097 03:29:35,462 --> 03:29:37,631 THE WORK HERE IS ON THE 6098 03:29:37,698 --> 03:29:38,399 PRE-CLINICAL UNTIL GETTING TO 6099 03:29:38,465 --> 03:29:39,700 THE FIRST IN HUMAN, BUT I'LL BE 6100 03:29:39,767 --> 03:29:43,437 HAPPY TO HEAR THOUGHTS THAT YOU 6101 03:29:43,504 --> 03:29:46,507 WANT TO ADD. 6102 03:29:46,573 --> 03:29:47,474 SOMETHING THAT OTHERWISE -- 6103 03:29:47,541 --> 03:29:49,476 >> SO I WOULD MAKE A VERY 6104 03:29:49,543 --> 03:29:54,448 SPECIFIC SURGS A VERYSPECIFIC SU 6105 03:29:54,515 --> 03:29:55,549 THINK ABOUT IT, THAT YOU TALK TO 6106 03:29:55,616 --> 03:29:58,118 THE BRAIN INITIATIVE ABOUT IT. 6107 03:29:58,185 --> 03:30:00,654 ACTUALLY THIS APPLIES TO ALMOST 6108 03:30:00,721 --> 03:30:02,289 ALL OF THE CONCEPT CLEARANCES 6109 03:30:02,356 --> 03:30:04,224 WE'VE DONE TODAY, ESPECIALLY THE 6110 03:30:04,291 --> 03:30:05,926 HUMAN STUDY ONES. 6111 03:30:05,993 --> 03:30:06,961 SO NONE OF THE GRANTS THAT GO 6112 03:30:07,027 --> 03:30:08,896 INTO THE BRAIN INITIATIVE, THE 6113 03:30:08,963 --> 03:30:11,131 LARGE GRANTS, KIND OF WHAT -- 6114 03:30:11,198 --> 03:30:13,701 THE HUMAN BRAIN GRANTS, MANY OF 6115 03:30:13,767 --> 03:30:15,202 WHICH ARE NOT FAR FROM THE EARLY 6116 03:30:15,269 --> 03:30:17,771 CONCEPT CLEARANCES THAT LIZZY 6117 03:30:17,838 --> 03:30:19,606 DESCRIBED, THEY ALL HAVE A 6118 03:30:19,673 --> 03:30:21,275 NEUROETHICIST INVOLVED, ALL OF 6119 03:30:21,342 --> 03:30:21,976 THEM. 6120 03:30:22,042 --> 03:30:25,379 IN THE TEAM. 6121 03:30:25,446 --> 03:30:26,847 NOT THAT THEY TALK TO EVERY TWO 6122 03:30:26,914 --> 03:30:27,181 YEARS. 6123 03:30:27,247 --> 03:30:28,115 ON THE TEAM. 6124 03:30:28,182 --> 03:30:29,750 THAT'S SOMETHING -- AND THERE'S 6125 03:30:29,817 --> 03:30:31,552 A WHOLE NEUROETHICS WORK GROUP 6126 03:30:31,618 --> 03:30:34,154 WITH THE BRAIN NICHE TV. 6127 03:30:34,221 --> 03:30:34,455 INITIATIVE. 6128 03:30:34,521 --> 03:30:37,491 IT REALLY NEEDS TO BE -- THERE 6129 03:30:37,558 --> 03:30:38,993 ARE PLENTY OF EXAMPLES WHERE 6130 03:30:39,059 --> 03:30:40,761 FIRST IN HUMAN TRIALS WERE 6131 03:30:40,828 --> 03:30:45,766 ETHICALLY CHALLENGING. 6132 03:30:45,833 --> 03:30:46,266 SO IT'S VERY IMPORTANT. 6133 03:30:46,333 --> 03:30:48,202 >> THANK YOU. 6134 03:30:48,268 --> 03:30:49,169 >> THANK YOU. 6135 03:30:49,236 --> 03:30:50,137 ANY OTHER COMMENTS, QUESTIONS 6136 03:30:50,204 --> 03:30:50,904 FROM MEMBERS? 6137 03:30:50,971 --> 03:30:51,205 GO AHEAD. 6138 03:30:51,271 --> 03:30:53,073 >> I'LL BE BRIEF. 6139 03:30:53,140 --> 03:30:53,941 DR. MACDONALD WAS RIGHT, I DID 6140 03:30:54,008 --> 03:30:55,609 WANT TO SAY SOMETHING ABOUT 6141 03:30:55,676 --> 03:30:56,276 IMPLEMENTATION AND ACTUALLY IT'S 6142 03:30:56,343 --> 03:30:57,411 TRUE FOR ALL THESE CONCEPT 6143 03:30:57,478 --> 03:30:57,711 CLEARANCES. 6144 03:30:57,778 --> 03:30:59,046 I REALLY ENCOURAGE YOU ALL TO 6145 03:30:59,113 --> 03:31:00,748 THINK ABOUT DESIGNING FOR 6146 03:31:00,814 --> 03:31:01,982 IMPLEMENTATION EVEN THOUGH IT'S 6147 03:31:02,049 --> 03:31:05,219 EARLY TRANSLATIONAL RESEARCH, TO 6148 03:31:05,285 --> 03:31:06,820 OPTIMIZE FOR ACCEPTABILITY AND 6149 03:31:06,887 --> 03:31:08,455 INCLUDE END USERS LIKE 6150 03:31:08,522 --> 03:31:09,456 CLINICIANS AND HUMANS WHO WILL 6151 03:31:09,523 --> 03:31:12,659 BE RECEIVING THE DEVICES IN THE 6152 03:31:12,726 --> 03:31:13,761 FUTURE AND TO INCLUDE AN 6153 03:31:13,827 --> 03:31:14,428 IMPLEMENTATION SCIENTIST ON THE 6154 03:31:14,495 --> 03:31:16,597 TEAM IF POSSIBLE AS PART OF THE 6155 03:31:16,663 --> 03:31:18,832 KIND OF MULTIDISCIPLINARY TEAM. 6156 03:31:18,899 --> 03:31:20,701 >> I WOULD LIKE TO ADD TO THAT 6157 03:31:20,768 --> 03:31:23,003 THIS WHEN YOU START THE PROCESS 6158 03:31:23,070 --> 03:31:24,938 OF THERAPEUTIC DEVELOPMENT, YOU 6159 03:31:25,005 --> 03:31:26,573 START WITH A PATIENT AND YOU 6160 03:31:26,640 --> 03:31:30,077 THICK WHTHINK WHAT'S THE NEEDS N 6161 03:31:30,144 --> 03:31:34,381 YOU GO AND START THE DEVELOP 6162 03:31:34,448 --> 03:31:35,816 DEVELOPMENT. 6163 03:31:35,883 --> 03:31:37,718 THIS IS BASICALLY SAYING -- YOU 6164 03:31:37,785 --> 03:31:38,452 START WITH THAT AND YOU GO TO 6165 03:31:38,519 --> 03:31:41,255 THE TARGET AND DEVELOP -- 6166 03:31:41,321 --> 03:31:42,189 >> THANK YOU VERY MUCH, 6167 03:31:42,256 --> 03:31:42,823 EVERYONE. 6168 03:31:42,890 --> 03:31:46,360 THANK YOU VERY MUCH. 6169 03:31:46,427 --> 03:31:47,561 WE'LL MOVE ON TO THE FINAL ITEM 6170 03:31:47,628 --> 03:31:49,296 ON THE AGENDA, WHICH IS THE 6171 03:31:49,363 --> 03:31:50,731 PUBLIC COMMENT SESSION FOR 6172 03:31:50,798 --> 03:31:52,933 TODAY'S MEETING, WE RECEIVED TWO 6173 03:31:53,000 --> 03:31:53,967 REQUESTS FOR COMMENT. 6174 03:31:54,034 --> 03:31:55,202 WHEN I CALL YOUR NAME S PLEASE 6175 03:31:55,269 --> 03:31:58,672 , PLEASECOME TO THE MICROPHONE D 6176 03:31:58,739 --> 03:31:59,640 COMPUTER THAT'S DIRECTLY ACROSS 6177 03:31:59,706 --> 03:32:00,174 FROM ME. 6178 03:32:00,240 --> 03:32:01,542 THE COMPUTER IS GOING TO HAVE A 6179 03:32:01,608 --> 03:32:03,444 CAMERA SO YOU CAN BE SITTING BY 6180 03:32:03,510 --> 03:32:04,445 THE VIRTUAL AUDIENCE. 6181 03:32:04,511 --> 03:32:06,246 PLEASE LIMIT YOUR COMMENTS TO 6182 03:32:06,313 --> 03:32:06,580 THREE MINUTES. 6183 03:32:06,647 --> 03:32:08,482 THE FULL TEXT OF YOUR SUBMITTED 6184 03:32:08,549 --> 03:32:09,683 COMMENTS HAVE BEEN PROVIDED TO 6185 03:32:09,750 --> 03:32:12,019 OUR COUNCILMEMBERS IN ADVANCE OF 6186 03:32:12,086 --> 03:32:13,153 TODAY'S MEETING, AND WILL BE 6187 03:32:13,220 --> 03:32:14,254 APPENDED TO OUR MEETING MINUTES 6188 03:32:14,321 --> 03:32:16,990 WHEN THEY ARE POSTED PUBLICLY. 6189 03:32:17,057 --> 03:32:19,293 SO I'D LIKE TO THANK BOTH OF THE 6190 03:32:19,359 --> 03:32:21,161 INDIVIDUALS WHO'VE REQUESTED TO 6191 03:32:21,228 --> 03:32:23,030 GIVE COMMENT TODAY. 6192 03:32:23,097 --> 03:32:25,632 AND THE FIRST ONE IS JAMES 6193 03:32:25,699 --> 03:32:28,502 CROMWELL. 6194 03:32:28,569 --> 03:32:29,470 MR. CROMWELL, PLEASE COME AGAIN 6195 03:32:29,536 --> 03:32:32,506 AND SIT IN THE CHAIR, AND MAKE 6196 03:32:32,573 --> 03:32:34,041 SURE YOU PRESS THE BUTTON ON THE 6197 03:32:34,108 --> 03:32:35,275 MICROPHONE UNTIL THE BUTTON 6198 03:32:35,342 --> 03:32:37,778 TURNS GREEN. 6199 03:32:37,845 --> 03:32:40,180 AND GO AHEAD AND MAKE YOUR 6200 03:32:40,247 --> 03:32:50,691 REMARKS WHEN YOU'RE READY. 6201 03:32:57,598 --> 03:32:58,665 >> GOOD AFTERNOON. 6202 03:32:58,732 --> 03:33:00,868 MY NAME IS JAMES CROMWELL. 6203 03:33:00,934 --> 03:33:02,269 FIRST OF ALL, I'D LIKE TO THANK 6204 03:33:02,336 --> 03:33:04,571 THE ADVISORY COUNCIL OF THE 6205 03:33:04,638 --> 03:33:06,206 NATIONAL INSTITUTE OF MENTAL 6206 03:33:06,273 --> 03:33:07,407 HEALTH FOR THE WORK YOU DO TO 6207 03:33:07,474 --> 03:33:09,042 IMPROVE THE LIVES OF INDIVIDUALS 6208 03:33:09,109 --> 03:33:11,745 SUFFERING WITH MENTAL ILLNESS. 6209 03:33:11,812 --> 03:33:13,247 I AM HERE AS PGH >> TRUSTEE 6210 03:33:13,313 --> 03:33:20,888 CROSBAN ANIMAL ADVOCATEAND ON BK 6211 03:33:20,954 --> 03:33:22,756 THAT YOU STOP WASTING MILLIONS 6212 03:33:22,823 --> 03:33:25,025 OF TAXPAYER DOLLARS ON EAR RIL 6213 03:33:25,092 --> 03:33:26,927 VANT EXPERIMENTS ON ANIMALS. 6214 03:33:26,994 --> 03:33:28,362 I AM ALSO HERE ON BEHALF OF THE 6215 03:33:28,428 --> 03:33:30,898 PEOPLE IN THIS COUNTRY WHO ARE 6216 03:33:30,964 --> 03:33:31,932 IN STRUGGLE TO RECOVER THEIR 6217 03:33:31,999 --> 03:33:33,634 MENTAL HEALTH. 6218 03:33:33,700 --> 03:33:35,802 I AM SURE YOU FEEL THE WEIGHT OF 6219 03:33:35,869 --> 03:33:38,272 YOUR RESPONSIBILITY, MILLIONS 6220 03:33:38,338 --> 03:33:40,507 LOOK TO YOUR AGENCY HOPING FOR 6221 03:33:40,574 --> 03:33:42,476 RELIEF FROM THE RAVAGES OF 6222 03:33:42,543 --> 03:33:44,645 MENTAL ILLNESS. 6223 03:33:44,711 --> 03:33:48,582 WE NEED YOU TO DO BETTER. 6224 03:33:48,649 --> 03:33:49,816 UNFORTUNATELY, I KNOW FROM 6225 03:33:49,883 --> 03:33:50,884 PERSONAL EXPERIENCE HOW 6226 03:33:50,951 --> 03:33:53,086 DEVASTATING IT IS TO WATCH A 6227 03:33:53,153 --> 03:33:55,055 LOVED ONE GRAPPLE WITH 6228 03:33:55,122 --> 03:33:56,456 DEBILITATING MENTAL ILLNESS. 6229 03:33:56,523 --> 03:33:59,226 A GREAT MANY PEOPLE ARE UNABLE 6230 03:33:59,293 --> 03:34:00,294 TO ACCESS TREATMENT OR EVEN FIND 6231 03:34:00,360 --> 03:34:02,262 A TREATMENT PLAN THAT ALLEVIATES 6232 03:34:02,329 --> 03:34:04,231 THEIR SYMPTOMS. 6233 03:34:04,298 --> 03:34:06,500 MANY OTHERS HAVE GIVEN UP TRYING 6234 03:34:06,567 --> 03:34:08,702 TO FIND HELP BECAUSE PAST 6235 03:34:08,769 --> 03:34:11,338 TREATMENTS HAVE FAILED THEM. 6236 03:34:11,405 --> 03:34:13,974 AS THIS COMMITTEE IS WELL AWARE, 6237 03:34:14,041 --> 03:34:15,909 MOST TREATMENTS FOR MENTAL 6238 03:34:15,976 --> 03:34:17,344 ILLNESS WERE FIRST DEVELOPED 50 6239 03:34:17,411 --> 03:34:19,413 YEARS AGO, AND THEY HAVEN'T 6240 03:34:19,479 --> 03:34:20,847 IMPROVED SINCE. 6241 03:34:20,914 --> 03:34:22,382 MANY HAVE GROSSLY UNPLEASANT 6242 03:34:22,449 --> 03:34:24,985 SIDE EFFECTS, AND THEY MOSTLY 6243 03:34:25,052 --> 03:34:26,086 ASSUREDLY DO NOT WORK FOR THE 6244 03:34:26,153 --> 03:34:28,422 VAST MAJORITY OF PEOPLE WHO ARE 6245 03:34:28,488 --> 03:34:31,758 DESPERATELY SEEKING RELIEF. 6246 03:34:31,825 --> 03:34:32,859 YOU MAY ALSO BE AWARE THAT MUCH 6247 03:34:32,926 --> 03:34:34,728 OF THE ANIMAL-BASED 6248 03:34:34,795 --> 03:34:35,395 EXPERIMENTATION YOU ARE 6249 03:34:35,462 --> 03:34:37,698 CURRENTLY FUNDING HAS LITTLE TO 6250 03:34:37,764 --> 03:34:39,533 NO RELEVANCE TO HUMAN MENTAL 6251 03:34:39,600 --> 03:34:42,169 ILLNESS AND WILL ASSUREDLY NEVER 6252 03:34:42,236 --> 03:34:46,006 LEAD TO NEW TREATMENTS AND CURES 6253 03:34:46,073 --> 03:34:47,174 FOR HUMANS. 6254 03:34:47,241 --> 03:34:48,742 DESPITE THIS, THE NIMH CONTINUES 6255 03:34:48,809 --> 03:34:51,678 TO FUNNEL MILLIONS OF DOLLARS 6256 03:34:51,745 --> 03:34:53,080 EACH YEAR INTO EXPERIMENTS THAT 6257 03:34:53,146 --> 03:34:55,816 HAVE NO HOPE OF BRINGING RELIEF 6258 03:34:55,882 --> 03:34:57,351 TO PEOPLE STRUGGLING WITH MENTAL 6259 03:34:57,417 --> 03:34:57,584 ILLNESS. 6260 03:34:57,651 --> 03:35:01,955 BY THAT, I MEAN EXPERIMENTS SUCH 6261 03:35:02,022 --> 03:35:03,924 AS DELIBERATELY BRAIN DAMAGING A 6262 03:35:03,991 --> 03:35:04,925 MONKEY. 6263 03:35:04,992 --> 03:35:06,293 THIS MONKEY IS NAMED SAM SMITH 6264 03:35:06,360 --> 03:35:07,961 AND I URGE YOU ALL TO READ 6265 03:35:08,028 --> 03:35:11,565 WHAT'S ON THE BACK. 6266 03:35:11,632 --> 03:35:14,401 A DESCRIPTION OF HIS LIFE. 6267 03:35:14,468 --> 03:35:16,136 FORCING MICE TO FIGHT EACH OTHER 6268 03:35:16,203 --> 03:35:19,840 AND SLEEP-DEPRIVING PRAIRIE 6269 03:35:19,906 --> 03:35:22,576 BULLS, NONE OF WHICH HAVE LED TO 6270 03:35:22,643 --> 03:35:23,443 HUMAN-RELEVANT TREATMENTS. 6271 03:35:23,510 --> 03:35:24,945 THE NIMH ALSO CONTINUES TO FUND 6272 03:35:25,012 --> 03:35:26,613 PROJECTS THAT USE THE 6273 03:35:26,680 --> 03:35:29,149 DISCREDITED FORCED SWIM TEST 6274 03:35:29,216 --> 03:35:33,487 THAT USES SMALL ANIMALS THAT ARE 6275 03:35:33,553 --> 03:35:35,555 NEARLY DROWNED IN INESCAPABLE 6276 03:35:35,622 --> 03:35:37,257 BEAKERS OF WATER IN ORDER TO 6277 03:35:37,324 --> 03:35:39,426 REPLICATE HUMAN DEPREPTION. 6278 03:35:39,493 --> 03:35:39,826 DEPRESSION. 6279 03:35:39,893 --> 03:35:42,195 WHAT SENSE DOES THAT MAKE? 6280 03:35:42,262 --> 03:35:44,097 THESE EXPERIMENTS HARM AND KILL 6281 03:35:44,164 --> 03:35:46,833 TENS OF THOUSANDS OF ANIMALS 6282 03:35:46,900 --> 03:35:47,934 EACH YEAR, AND THEY ULTIMATELY 6283 03:35:48,001 --> 03:35:49,903 COME AT THE EXPENSE OF IMMEDIATE 6284 03:35:49,970 --> 03:35:53,407 COMMUNITY AND PATIENT NEEDS. 6285 03:35:53,473 --> 03:35:54,841 THERE ARE MILLIONS OF PEOPLE IN 6286 03:35:54,908 --> 03:35:56,043 THE U.S. SUFFERING WITH MENTAL 6287 03:35:56,109 --> 03:35:57,444 ILLNESS RIGHT NOW WHO NEED THE 6288 03:35:57,511 --> 03:35:59,079 NIMH TO HELP THEM. 6289 03:35:59,146 --> 03:36:00,881 RATHER THAN TO CONTINUE TO WASTE 6290 03:36:00,947 --> 03:36:02,215 PRECIOUS RESOURCES ON 6291 03:36:02,282 --> 03:36:03,684 EXPERIMENTS THAT WILL NOT 6292 03:36:03,750 --> 03:36:06,720 TRANSLATE TO HUMANS. 6293 03:36:06,787 --> 03:36:08,822 THIS MISAPPLICATION OF FUNDING 6294 03:36:08,889 --> 03:36:10,157 IS IRRESPONSIBLE. 6295 03:36:10,223 --> 03:36:12,192 IT IS IN DIRECT CONFLICT WITH 6296 03:36:12,259 --> 03:36:15,362 THE INSTITUTE'S MISSION TO PAVE 6297 03:36:15,429 --> 03:36:16,897 THE WAY FOR PREVENTION, RECOVERY 6298 03:36:16,963 --> 03:36:19,766 AND ULTIMATELY CURES. 6299 03:36:19,833 --> 03:36:20,934 TO ADDRESS THE MENTAL HEALTH 6300 03:36:21,001 --> 03:36:22,302 CRISIS OUR NATION IS FACING, WE 6301 03:36:22,369 --> 03:36:24,037 ARE ASKING THE ADVISORY COUNCIL 6302 03:36:24,104 --> 03:36:25,439 TO TAKE IMMEDIATE STEPS TO 6303 03:36:25,505 --> 03:36:27,641 REDIRECT THE RESOURCES BEING 6304 03:36:27,708 --> 03:36:30,811 WASTED ON USELESS ANIMAL-BASED 6305 03:36:30,877 --> 03:36:34,314 RESEARCH AT THE EXPENSE OF MORE 6306 03:36:34,381 --> 03:36:37,284 HUMAN -- OF MORE HUMAN RELEVANT 6307 03:36:37,351 --> 03:36:38,452 AND RESEARCH METHODS. 6308 03:36:38,518 --> 03:36:40,454 I AM NOT ALONE. 6309 03:36:40,520 --> 03:36:45,559 I HAVE HERE A LETTER SIGNED BY 6310 03:36:45,625 --> 03:36:47,427 NEARLY 400 PHYSICIANS, 6311 03:36:47,494 --> 03:36:49,629 SCIENTISTS AND MENTAL HEALTH 6312 03:36:49,696 --> 03:36:50,931 PROFESSIONALS, AS WELL AS A 6313 03:36:50,997 --> 03:36:52,632 PETITION SIGNED BY MORE THAN 6314 03:36:52,699 --> 03:36:54,768 50,000 MEMBERS OF THE GENERAL 6315 03:36:54,835 --> 03:36:57,270 PUBLIC, ALL OF WHOM IMPLORE NIMH 6316 03:36:57,337 --> 03:37:00,440 TO STOP FUNDING CRUEL AND 6317 03:37:00,507 --> 03:37:01,074 FRUITLESS EXPERIMENTS ON ANIMALS 6318 03:37:01,141 --> 03:37:02,509 AND START FUNDING RESEARCH THAT 6319 03:37:02,576 --> 03:37:04,044 CAN TRULY HELP THE PEOPLE 6320 03:37:04,111 --> 03:37:05,812 STRICKEN WITH THESE DEBILITATING 6321 03:37:05,879 --> 03:37:06,246 ILLNESSES. 6322 03:37:06,313 --> 03:37:09,616 IN CONCLUSION, WE URGE THE NIMH 6323 03:37:09,683 --> 03:37:14,187 TO DO THE FOLLOWING: REALLOCATE 6324 03:37:14,254 --> 03:37:15,989 NIMH INTRAMURAL AND EXTRAMURAL 6325 03:37:16,056 --> 03:37:18,925 RESEARCH FUNDING TO ANIMAL-FREE 6326 03:37:18,992 --> 03:37:20,927 HUMAN-RELEVANT MODELS. 6327 03:37:20,994 --> 03:37:22,662 TWO, PROVIDE REGULATORS AND 6328 03:37:22,729 --> 03:37:23,663 RESEARCHERS WITH TRAINING IN THE 6329 03:37:23,730 --> 03:37:26,600 USE OF HUMAN-RELEVANT MODELS. 6330 03:37:26,666 --> 03:37:28,135 AND THREE, INCREASE THE AMOUNT 6331 03:37:28,201 --> 03:37:31,605 OF FEDERAL FUNDING ALLOCATED TO 6332 03:37:31,671 --> 03:37:32,939 PREVENTIVE MEASURES, IMPROVING 6333 03:37:33,006 --> 03:37:34,374 ACCESS TO CARE. 6334 03:37:34,441 --> 03:37:35,375 THANK YOU FOR YOUR 6335 03:37:35,442 --> 03:37:37,778 CONSIDERATION. 6336 03:37:37,844 --> 03:37:39,179 >> THANK YOU FOR YOUR COMMENTS, 6337 03:37:39,246 --> 03:37:40,747 AND THANK YOU FOR MAKING THE 6338 03:37:40,814 --> 03:37:44,184 TRIP AND YOUR HEARTFELT ADVOCACY 6339 03:37:44,251 --> 03:37:45,519 FOR INDIVIDUALS WITH -- BEARING 6340 03:37:45,585 --> 03:37:48,321 THE BURDEN OF MENTAL ILLNESS. 6341 03:37:48,388 --> 03:37:51,858 OUR NEXT SPEAKER IS STEVEN 6342 03:37:51,925 --> 03:37:52,359 FARGOLI. 6343 03:37:52,426 --> 03:37:54,895 I HOPE I'M PRONOUNCING THAT 6344 03:37:54,961 --> 03:37:56,563 CORRECTLY. 6345 03:37:56,630 --> 03:37:57,397 PLEASE COME TO THE SAME 6346 03:37:57,464 --> 03:37:57,664 LOCATION. 6347 03:37:57,731 --> 03:37:58,698 >> WHEN CAN I SUBMIT THE 6348 03:37:58,765 --> 03:37:59,199 DOCUMENTS? 6349 03:37:59,266 --> 03:38:00,967 >> PLEASE, YOU CAN BRING IT 6350 03:38:01,034 --> 03:38:06,606 RIGHT HERE. 6351 03:38:06,673 --> 03:38:08,875 >> IS IT MR. FARGOLI? 6352 03:38:08,942 --> 03:38:12,379 ARE YOU HERE? 6353 03:38:12,446 --> 03:38:15,015 WELL, I NOTE WE HAVE 6354 03:38:15,081 --> 03:38:16,349 MR. FARGOLI'S WRITTEN COMMENTS. 6355 03:38:16,416 --> 03:38:18,652 THEY WILL BE, AGAIN, APPENDED TO 6356 03:38:18,718 --> 03:38:21,455 THE MINUTES AND PUBLICLY POSTED. 6357 03:38:21,521 --> 03:38:23,323 THANK YOU VERY MUCH. 6358 03:38:23,390 --> 03:38:24,958 THAT BRINGS US TO THE CONCLUSION 6359 03:38:25,025 --> 03:38:27,494 OF THIS OPEN SESSION OF COUNCIL. 6360 03:38:27,561 --> 03:38:30,030 I VERY MUCH APPRECIATE THE 6361 03:38:30,096 --> 03:38:32,432 OPPORTUNITY TO WORK WITH YOU 6362 03:38:32,499 --> 03:38:34,167 ALL, MEMBERS OF COUNCIL, FOR THE 6363 03:38:34,234 --> 03:38:35,602 PAST SEVERAL YEARS. 6364 03:38:35,669 --> 03:38:36,903 MEMBERS OF THE NIMH COMMUNITY 6365 03:38:36,970 --> 03:38:40,307 FOR MUCH LONGER. 6366 03:38:40,373 --> 03:38:44,444 AND IT'S BEEN A PLEASURE. 6367 03:38:44,511 --> 03:38:46,179 WE MEET TOMORROW AT -- 6368 03:38:46,246 --> 03:38:47,447 >> 9:00 A.M. 6369 03:38:47,514 --> 03:38:49,716 >> -- 9:00 A.M. IN THIS ROOM 6370 03:38:49,783 --> 03:38:51,151 FOR THE CLOSED SESSION, IN WHICH 6371 03:38:51,218 --> 03:38:52,452 WE WILL CONSIDER THE NEXT ROUND 6372 03:38:52,519 --> 03:38:54,354 OF GRANTS FOR FUNDING. 6373 03:38:54,421 --> 03:38:57,824 THANK YOU VERY, VERY MUCH. 6374 03:38:57,891 --> 03:39:05,065 [APPLAUSE]