>>WELCOME TO NIGMS COUNCIL MEETING THIS MAY. I AM JOHN, DIRECTOR OF NIGMS AND WE'RE GOING TO START BY DOING INTRODUCTIONS AND I WILL GO AROUND THE ROOM BASED ON THE ROSTER BUT FIRST LET'S INTRODUCE SOME OF THE NG I GM S PEOPLE. >> HI, I AM TERESA, DEPUTY DIRECTOR OF NIGMS. >> AND WE ALSO HAVE DAR RAIN HERE, IF YOU HAVE ANY PROBLEMS OR ISSUES, PLEASE SEND A NOTE TO DAR RAIN OR ERICA AND THEY CAN HELP RESOLVE THAT. WHY DON'T WE START WITH COUNCIL MEMBERS NATALIE, YOU WANT TO INTRODUCE YOURSELF? >> HI, I AM NATALIE AHN UNIVERSITY OF COLORADO DEPARTMENT OF BIOCHEMISTRY. >> GREAT, DAR RAIN? >> HI EVERYBODY, I AM DARRIN AKINS, OKLAHOMA UNIVERSITY SCIENCE CENTER, DIRECTOR OF MICROBIOLOGY AND IMMUNOLOGY AND WE WORK ON HOW PROTEINS ARE TRANSPORTED AND INSERTED IN THE LIPID BIOLAYERS. >> THANK YOU, SQUIRE? >> GOOD MORNING -- [ INDISCERNIBLE ] MEDICAL INSTITUTE, DEPARTMENT OF BIOCHEMISTRY, DEPARTMENT OF CHEMISTRY, WE WORK WITH ENZYME REACTION MECHANISMS, PARTICULARLY ENZYMES THAT USE COFACTORS AND CATHOLISIS AND WORK ON BIOESSENCE OF NATIONAL PRODUCTS. >> THANK YOU, ANGELA? >> GOOD MORNING, UNIVERSITY OF WISCONSIN MADISON, PROFESSOR OF DEPARTMENT OF MEDICINE AND MY RESEARCH IS FOCUSING ON THE EFFECTIVE MENTORSHIP, MULTICULTURAL ISSUES AND FUNCTION THING IN. THANK YOU. >> THANK YOU, SARAH? >> HI, I AM SARAH COHEN, ASSISTANT PROFESSOR AT UNC CHAPEL HILL AND WORK ON LIPID TRAFFICKING IN BETWEEN CELLS. >> THANK YOU, ANGELA? >> GOOD MORNING, EVERYBODY, MY NAME IS ANGELA DEPACE AND ASSOCIATE PROFESSOR AT BIO-- [INDISCERNIBLE] AND MOST RECENTLY THROUGH BEING A FACTOR DIRECTOR OF THE SCIENTIFIC CITIZENSHIP INITIATIVE WHICH TEACHES STUDENTS SKILLS AND DISPOGZ FOR EFFECTIVE -- [INDISCERNIBLE] >> THANK YOU, PETER? >> MORNING, I AM PETER ES PENSHADE FROM JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE IN THE DEPARTMENT OF BIOLOGY. AND I AM ALSO THE DEAN OF THE GRADUATE STUDENTS AT THE SCHOOL. >> THANK YOU, LAURA GIBSON? >> GOOD MORNING, I'M AT WEST VIRGINIA UNIVERSITY HEALTH SCIENCE CENTER, PROFESSOR IN THE DEPARTMENT OF MICROBIOLOGY, IMMUNOLOGY AND CELL BIOLOGY. OUR LAST FOCUS IS ON UNDERSTANDING HOW THE MICROBIOLOGY DEPARTMENT THERAPY -- [INDISCERNIBLE] ON THE SIDE, I AM BC FOR RESEARCH AND GRADUATES. >> GOOD MORNING, EVERYONE, I AM WITH UNIVERSITY OF SOUTHERN CALIFORNIA, DEPARTMENT OF TRANSLATIONAL GENUINE MOMENT MIX, THE SCHOOL OF MEDICINE. MY FOCUS IS A LITTLE DIFFERENT WHICH IS THE ACTUAL TRANSLATION AND COMMERCIALIZATION OF BIOMEDICAL PRODUCTS AND SERVICES. >> THANK YOU, ANDRE, GREAT TO HAVE YOU HERE, TERRY KINSEY? >> TERRY THERE YET? ALL RIGHT, LOOKS LIKE TERRY IS NOT HERE YET. >> HE IS HERE. I AM NOT SURE WHY SHE IS NOT ANSWERING AT THE MOMENT. >> WELL WE'LL COME BACK TO TERRY IN A MINUTE -- >> CAN YOU HEAR ME? CAN YOU HEAR ME NOW? >> THERE YOU ARE. >> SORRY, I AM ON THE PHONE TEMPORARILY, TERRY KINSEY, PROFESSOR OF BIOLOGICAL SCIENCES. MY RESEARCH IS FOCUSED ON TRANSLATIONAL ELONGATION. >> EXCELLENT, THANK YOU, TERRY. DANIELLE LI? >> HI, I AM ASSOCIATE PROFESSOR AT MIT SLOAN SCHOOL AND -- [INDISCERNIBLE] >> THANK YOU, DANIELLE, DAVID MATTHEWS? >> UNIVERSITY OF ROCHESTER, DEPARTMENT OF OUTCOME STREAK RECOMMENDS AND MICROSPACE RNA USING COMPUTATIONAL METHODS. >> THANK YOU, VERA? >> FROM THE DEPARTMENT OF SYSTEM FORM COLLING AND THERAPEUTICS AT THE UNIVERSITY OF PENN AND ON THE SIDE STUDYING -- [INDISCERNIBLE] >> THANK YOU, LESLIE RHODES? >> GOOD MORNING, I AM A PROFESSOR AT THE UNIVERSITY OF CALIFORNIA UC DAVIS AND MY LAB STUDIES CLINICAL POSITION AND POLE LATER IN ASYMMETRIC DIVISION. >> THANK YOU, AMY? >> HI, I AM AMY ROSENZWEIG, IN THE DEPARTMENTS OF MICROBIOLOGY AND CHEMISTRY, A BIOCHEMIST AND STRUCTURAL BIOLOGIST AND WE'RE INTERESTED IN META HOMEOSTASIS AND ENZYMES. >> THANK YOU, MELANIE SANFORD? >> HEY, I AM IN THE DEPARTMENT OF CHEMISTRY AT THE UNIVERSITY OF MICHIGAN AND MY GROUP, I AM AN ORGANIC CHEMIST AND MY GROUP STUDIES -- [INDISCERNIBLE] >> THANK YOU, CRIST -- CHRIS MOORE? >> HI, EVERYONE, CLINICAL PROFESSOR AT UNIVERSITY OF PITTSBURGH, SPEND MY TIME AS CHEMICAL -- [INDISCERNIBLE] >> THANK YOU. PAUL? >> GOOD MORNING, IMPROV SORE IN THE DEPARTMENT OF BIOCHEMISTRY AT THE UNIVERSITY OF UTAH SCHOOL OF MEDICINE SALT LAKE CITY AND WE'RE INTERESTED IN UNDERSTANDING METABOLIC ADAPTATIONS AND ORGAN FUNCTIONS IN. >> PAM? >> I AM NOT SEEING PAM YET. >> OKAY, THEN WE GO TO JEFF. >> PROFESSOR OF LAW AT UNIVERSITY OF GOOGLE AND STUDY THE INTERSECTION OF HIGHER EDUCATIONAL LAW. >> EXCELLENT, I THINK THAT IS EVERYBODY WHO IS SUPPOSED TO BE HERE, PAM ARE YOU HERE? >> YES, GOOD MORNING, GOOD TO BE WITH YOU ALTHOUGH LATE, I AM A PROFESSOR EMERITUS AT SAN JOSE STATE UNIVERSITY DEPARTMENT OF CHEMISTRY AND FORMER ASSOCIATE VICE-PRESIDENT FOR RESEARCH. GOOD TO BE HERE. >> THANK YOU PAM AND WE CERTAINLY UNDERSTAND THE TIME DIFFERENCE BETWEEN HERE AND THE WEST COAST SO THANK YOU FOR GETTING ON EARLY. WE HAVE, LET'S SEE, ONE ORDER OF ADMINISTRATIVE BUSINESS I NEED TO TAKE CARE OF WHICH IS CONSIDERATION OF THE MINUTES FROM THE LAST MEETING. DO WE HAVE ANY COMMENTS ON THE MINUTES OR REQUESTS FOR CHANGES? OKAY, HEARING NONE, I WILL ASK IF THERE IS ANYONE WHO DISCENTS FROM APPROVING THE MINUTES, RAISE YOUR HAND? OKAY, I DON'T SEE ANY DISSENT SO WE WILL CONSIDER THE MINUTES FROM THE LAST MEETING APPROVED AND WITH THAT, I MUST TURN TO THE DIRECTOR'S REPORT AND GIVE YOU UPDATES ON WHAT HAS BEEN GOING ON AROUND THE INSTITUTE IN THE LAST FEW MONTHS. THERE WE GO. SO THANK YOU ALL AGAIN FOR PARTICIPATING IN THE COUNCIL ROUND THIS MAY. NEXT SLIDE, PLEASE. JUST TO REINTRODUCE A COUPLE OF PEOPLE, WE HAVE A COUPLE OF AD HOC COUNCIL PARTICIPANTS, VERA AND CHRIS WHO JUST INTRODUCED THEMSELVES AND WELCOME TO THEM AND WE'RE LOOKING FORWARD TO GETTING THEIR INPUT AND PERSPECTIVES. NEXT SLIDE, PLEASE. AND AS WE HAVE DONE FOR YEARS NOW, WE HAVE TWO EARLY INVESTIGATORS PARTICIPANTS, SARAH AND PAUL AND VALUE THE INPUT OF HAVING THEM ON OUR COUNCIL AND HOPE THEY WILL HAVE US DISSEMINATE WHAT GOES ON THE COUNCIL AND MAKE IT A LITTLE MORE TRANSPARENT TO EARLY CAREER INVESTIGATORS AND TRAINEES. NEXT SLIDE, PLEASE. WE DO HAVE SOME PERSONNEL CHANGES AROUND THE INSTITUTE. FIRST WE WANT TO WELCOME KEE WING CHOW IN THE DIVISIONAL GENETICS CELLULAR AND DEVELOPMENTAL BIOLOGY -- CHI-WING CHOW. WELCOME. AND THEN WE HAVE SOME DEPARTURES, AND NEXT SLIDE, PLEASE. AND TANYA HAS ALSO TAKEN A NEW POSITION, A PROMOTION AT THE NATIONAL INSTITUTE OF DENTAL CRANIOFACIAL RESEARCH AND ALSO GIVING GOODBYE TO GARY MARLOWE WHO WILL BE MOVING ON TO NI GM S. WE WISH THEM THE BEST. NEXT SLIDE, PLEASE. A BIG DEPARTURE HAS BEEN NED SHARPLETS WHO TOOK A 7-MONTH HIATUS IN 2018 TO BE ACTING COMMISSIONER OF THE FDA K-FPLT HE WAS REALLY A GREAT COLLEAGUE, ADVOCATED FOR POLICIES TO INSURE MORE SUPPORT FOR INVESTORS -- INVESTIGATIVE ISSUES IN CANCER RESEARCH AS WELL AS DIVERSITY IN CANCER RESEARCH AND SUPPORT FOR EARLY CAREER INVESTIGATORS. HE WILL BE MISSED, NOT JUST AT NIH BUT I THINK FOR THE GOVERNMENT IN GENERAL TO HAVE NED RETURN TO NORTH CAROLINA AND HOPEFULLY WILL CONTINUE, I AM SURE, TO DO GREAT THINGS THERE. DOUG LOWR Y WILL, I THINK FOR THE THIRD TIME, BE THE ACTING DIRECTOR OF NCI WHILE A SEARCH FOR NED'S REPLACEMENT TAKES PLACE. NEXT SLIDE, PLEASE. COUPLE OF SAVE THE DATES WE WANT TO MAKE YOU AWARE OF, THE JUDITH GREENBURG EARLY CAREER INVESTIGATOR LECTURE, THAT WILL BE SEPTEMBER 28TH, 1-2:00 P.M. AND BROADCAST VIA VIDEOCAST AND RECORDED SO PEOPLE CAN WATCH IT LATER IF THEY CAN'T COME AT THAT TIME. THE DEWITT STETTEN LECTURE WILL BE GIVEN BY SALLY HODDER FROM WEST VIRGINIA UNIVERSITY AND TALKING ABOUT CLINICAL RESEARCH HER AND HER COLLEAGUES HAVE BEEN DOING AND WHAT THEY HAVE DONE TO BUILD CAPACITY AT THE INSTITUTION. THAT WILL BE NOVEMBER 30TH, 3-4:00 P.M. AND WILL BE RECORDED SO YOU CAN WATCH IT AT A LATER DAY. PUT THOSE ON YOUR CALENDAR. I THINK THEY WILL BE TERRIFIC TALKS. NEXT SLIDE, PLEASE. AND A NEW RESOURCE THAT HAS JUST BEEN STOOD UP WITH NEW LEADERSHIP AT NIGMS IS A NEW STEM TEACHING RESEARCH PORTAL PROVIDING FREE AND EASY ACCESS MATERIAL THAT EDUCATORS OR PARENTS OR OTHERS CAN USE TO ENGAGE K-12 STUDENTS IN SCIENCE. IT WAS LAUNCHED LAST MONTH AND MANAGED BY NIGMS AND WE ALSO STOOD UP A NIH-WIDE COORDINATING STEM COMMITTEE THAT NIH IS LEADING WITH HELP FROM OTHER CENTERS. THE SITE FEATURES A WHOLE LOT OF EDUCATIONAL MATERIAL INCLUDING RESOURCES FUNDED THROUGH OUR SEPA PROGRAM WHICH YOU WILL BE HEARING ABOUT SOON. THE SITE WAS FEATURED IN THE NATIONAL SCIENCE TEACHING ASSOCIATION NEWSLETTER WHICH HAS CLOSE TO 250,000 SUBSCRIBERS SO THAT MAKES IT PRETTY EXCITING THAT THEY WERE ABLE TO PICK THAT UP AND WE HAVE BEEN SHARING IT ON SOCIAL MEDIA BUT PLEASE HELP MAKE OTHERS AWARE OF THE WEBSITE AND RESOURCES IT HAS, IT IS GIVEN HERE AND I THINK THERE ARE QUITE USEFUL SITES FOR YOUNG PEOPLE TO GET ENGAGED ABOUT LEARNING IN SCIENCE. NEXT SLIDE, PLEASE. RELATED TO THAT WE HAVE PUT OUT ANOTHER ISSUE OF PATHWAYS MAGAZINE, THIS ONE WE DID IN COLLABORATION WITH THE VICE-PRESIDENT, KAMALA HARRIS AND IT IS ON THE VIRUS, VACCINES, PARTICULARLY THE COVID-19 VIRUS. IT REACHED AN ESTIMATED TWO AND A HALF MILLION MIDDLE AND HIGH SCHOOL STUDENTS AND 19,000 TEACHERS ACROSS ALL 50 STATES. IT HAS A LOT OF ASSOCIATED CONTENT IN THE MAGAZINE, ONLINE INFORMATION THAT IS FREE INCLUDING RESEARCH, LESSON PLANS TO CURRICULUM STANDARDS SO TEACHERS CAN USE THEM IN THE CLASSROOM. IF YOU ARE INTERESTED IN THAT, YOU CAN GO TO THE WEBSITE THERE AND SEE WHAT THAT IS ALL ABOUT BUT THE IDEA WHICH WAS THE VICE-PRESIDENT'S WAS TO LEVERAGE THE PANDEMIC TO BE SORT OF A SPUTNIK KIND OF A MOMENT TO GET KIDS MORE INTERESTED IN FOLLOWING CAREERS IN BIOMEDICAL RESEARCH. AND AS YOU KNOW, THE VICE-PRESIDENT HERSELF HAS A CONNECTION TO BIOMEDICAL RESEARCH BECAUSE HER MOTHER WAS A CANCER RESEARCHER. NEXT SLIDE, PLEASE. NOW RELATED TO S EPA WHICH I MENTIONED JUST A MINUTE AGO, A NEW INITIATIVE THAT COMES FROM THE UNITE PROGRAM WHICH YOU MAY RECALL FROM PREVIOUS COUNCIL ROUNDS, AN NIH-WIDE INITIALIVE TO COMBAT STRUCTURAL RACISM IN BIOMEDICAL RESEARCH AND THE BIOMEDICAL RESEARCH ENTERPRISE. THIS NEW INITIATIVE IS TO EXPAND THE S EPA PROGRAM AND PARTNERSHIP PROGRAM TO INCLUDE OTHER NIH CENTERS. SO THE NATIONAL INSTITUTE OF HUMAN GENETICS, HUMAN GENOMICS, PUT OUT A NOTICE THAT WAS ANNOUNCED BY THE PARTICIPATION OF ADDITIONAL NIH CENTERS IN S EPA AND THAT WILL ALLOW THEM TO FUND PROJECTS WHICH AGAIN ARE IN THE PRE-K THROUGH 12 EDUCATION SPACE. SO FAR, 16NIH CENTERS HAVE JOINED NIGMS AND WILL BE ABLE TO FUND SEPA AWARDS. APPLICATIONS WILL COME IN AS THEY HAVE IN THE PAST THROUGH NIGMS AND PARTICIPATING ICS WILL BE ABLE TO SELECT THE ONES THEY WILL INTERESTED IN TO FUND AND THE SEPA AWARDEES FUNDED BY ALL THE OTHER ICS WILL BE ABLE TO PARTICIPATE IN PROGRAM-WIDE ACTIVITIES THAT NIGMS LEADS AND ABLE TO PARTICIPATE FROM THE PAST SO IT WILL BE SEEN FROM THE GRANTEES POINT OF VIEW. VERY IMPORTANTLY, THE GOAL HERE IS TO FUND MORE SEPA GRANTS SO NIGMS CONTINUES ITS COMMITMENT ARE TO FUND THE S EPA PROGRAM, AND THE PARTICIPATION OF OTHER ICS WILL ALLOW MORE TO BE FUNDED. SO THAT MEANS WE NEED TO SEE MORE SEPA APPLICATIONS SO WE CAN HAVE A SUFFICIENT NUMBER OF MER TORE -- MER TORE CROSS APPLICATIONS TO AWARD SO THAT MEANS WE WILL HAVE MORE FROM EVERY STATE IN THE COUNTRY HOPEFULLY. NEXT SLIDE, PLEASE. WANT TO GIVE YOU A BRIEF UPDATE ON MOSAIC PROGRAM, A PROGRAM LED BY IGMS AIMED AT PROMOTING CAREER TRANSITION FROM POSTDOC TO RESEARCH INTENSIVE CAREERS OF DIVERSE RESEARCHERS. AND THE GOAL IS TO ENHANCE THE DIVERSITY OF FACULTY AT RESEARCH-INTENSIVE POSITIONS. SO FAR, 23NIH INSTITUTE CENTERS AND OFFICES NOW PARTICIPATE IN MOSAIC MAKING IT A TRUE ALIGNS PROGRAM AND PART OF THE PROGRAM YOU MAY RECALL ARE THE K99 AWARDS AND WE JUST ANNOUNCED THE FIRST GROUP OF AWARDEES IN 2022 SHOWN HERE. APPLICATIONS COME IN THREE TIMES A YEAR SO WE WILL BE MAKING TWO MORE ROUNDS THIS YEAR OF ADDITIONAL SCHOLARS. YOU CAN LEARN MORE ABOUT THE PROGRAM ON THE URL GIVEN THERE AND LOOK FORWARD TO ANOTHER TREMENDOUS CLASS OF DIVERSE RESEARCHERS AND HELPING THEM FOLLOW THEIR CAREERS INTO INDEPENDENT RESEARCH POSITIONS. NEXT SLIDE, PLEASE. ALSO IN THE TRAINING FRONT, WE ARE LOOKING AT SEEKING INPUT FROM STUDENTS AND TRAINEES TO GENERALLY FIND OUT WHAT THEY ARE FEELING AND EXPERIENCING AND HOW TO IMPROVE THE RESEARCH TRAINING SO THE PROGRAM IS TRYING TO GET MORE INFORMATION FROM TRAINEES, WE PUT OUT OUR REQUEST FOR INFORMATION ON IMPROVING RESEARCH TRAINING, CAREER PROGRESSION AND EDUCATIONA L ENVIRONMENT, INTERESTED IN HEARING FROM ALL TRAINEES BUT ESPECIALLY THOSE INVOLVED WITH THE NIGMS-FUNDED PROGRAMS AND THE COMMENT DEADLINE IS MAY 28TH SO LET THOSE YOU KNOW IN YOUR LAB AND ELSEWHERE ABOUT THE OPPORTUNITY. YOU CAN POINT THEM BACK TO THE FEEDBACK LOOP BLOG POST AT THE SUBJECT URL AND WE HOPE TO GET ROBUST RESPONSE AND DIRECT INPUT FROM TRAINEES. NEXT SLIDE, PLEASE. NOW, I WOULD LIKE TO TALK A LITTLE BIT ABOUT SOME OF THE WORK WE ARE DOING IN CLOUD COMPUTING AND THE REASON I THINK AS WE DISCUSSED IN PREVIOUS COUNCIL ROUNDS THAT WE'RE PARTICULARLY INTERESTED AND EXCITED ABOUT THE POSSIBILITIES OF CLOUD COMPUTING ARE WE THINK IT HAS A POTENTIAL TO DEMOCRATIZE SCIENCE. AS YOU KNOW, NIGMS SUPPORTS CAPTAIN PAST BUILDING AND TRAINING AT MANY INSTITUTIONS, 400 IN 24IDEA STATES AND 100 MINORITY SERVING INSTITUTIONS ACROSS THE COUNTRY. MOST OF THEM DON'T HAVE THEIR OWN COMPUTING SYSTEMS THAT SUPPORT THAT KIND OF RESEARCH DIRECTLY WHICH IS A CHALLENGE CERTAINLY GIVEN THE INCREASING IMPORTANCE OF BIG DATA AND DATA SCIENCE BUT THE CLOUD REALLY PROVIDES A OPPORTUNITY TO OPEN THAT RESEARCH UP TO ANY INSTITUTION OF THE COUNTRY BECAUSE WE DON'T HAVE TO SUPPORT -- INSTITUTIONS DON'T HAVE TO SUPPORT THEIR OWN HIGH PERFORMANCE COMPUTERS, ACCESS TO DATA SCIENCE TOOLS OR THEIR OWN STORAGE OF THE DATA. THAT CAN ALL BE DONE IN THE CLOUD AND ALL THEY REALLY NEED IS A HIGH SPEED INTERNET CONNECTION. AND SO WE THINK THAT THE OPPORTUNITY TO DRAMATICALLY INCREASE ACCESS TO THESE KINDS OF TOOLS AND DRAMATICALLY INCREASE TRAINING AND RESEARCH IN DATA SCIENCE AT INSTITUTIONS WITH LESSER RESOURCES IS REALLY TREMENDOUS THROUGH THE CLOUD AND SO THAT'S SOMETHING WE'RE TRYING TO EXPLORE HOW WE CAN FURTHER LEVERAGE THE CLOUD IN THIS WAY AND MAKE AVAILABLE THESE KINDS OF RESEARCH AND TRAINING OPPORTUNITIES. NEXT SLIDE, PLEASE. SO WE HAVE DONE A FEW THINGS. ONE IS WE HAVE JUST ASKED THE COMMUNITY FOR THEIR THOUGHTS ON THIS GENERAL STRATEGY AND SO WE HAD A CLOUD COMPUTING REQUEST FOR INFORMATION LAST SUMMER AS WELL AS A WORKSHOP IN THE FALL. THIS WAS IN COLLABORATION WITH THE NIH OFFICE OF DATA SCIENCE STRATEGY AND THE NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES. THE RFI CLOSED IN SEPTEMBER AND THEN WE HAD A WORKSHOP ALSO IN SEPTEMBER WHERE WE INVITED PEOPLE FROM UNDERSERVED, UNDER RESOURCED INSTITUTIONS, PARTICULARLY MINORITY SERVING INSTITUTIONS TO GET INPUT ON BOTH THEIR OPPORTUNITIES THEY SEE PROVIDED BY THE CLOUD AS WELL AS CHALLENGES IN MEETING THOSE OPPORTUNITIES. AND THAT WAS REALLY ONE CLEAR NEED IDENTIFIED WHICH WAS THE NEED FOR MORE TRAINING OPPORTUNITIES IN CLOUD COMPUTING AND HOW TO USE THE CLOUD. NEXT SLIDE PLEASE. SO WE HAVE BEEN PILOTING A IDEA IN HOW TO, IN ONE WAY TO DO THAT, WHICH IS TO ENABLE THE CREATION OF TRAINING MODULES, OF LEARNING MODULES THAT BOTH HELP STUDENTS AND RESEARCHERS LEARN A SPECIFIC AREA OF DATA ANALYSIS, PARTICULARLY USING THE CLOUD, HOW TO DO DATA ANALYSIS IN THAT AREA IN THE CLOUD, BUT AT THE SAME TIME, LEARNING THE BASIC FUNDAMENTALS OF WORKING WITHIN THE CLOUD. SO THEY LEARN THE SCIENTIFIC AREAS OF THE DATA ANALYSIS AREA, BUILD THE DATA SCIENCE, ANALYTICS TOOLS AND ALSO LEARN CLOUD COMPUTING TOOLS IN GENERAL BECAUSE THE ENVIRONMENT THEY ARE WORKING IN IS IN THE CLOUD. AND WE DID AS A PILOT SUPPORT THE DEVELOPMENT OF TWO SUCH LEARNING MODULES LAST YEAR. THESE WERE A MASSPEC DATA ANALYSIS BY THE UNIVERSITY OF ARKANSAS AND THEN A RNA SEQ ANALYSIS BY THE UNIVERSITY OF MAIN. SO THESE MODULES ALONG WITH COMPLETING MODULES THAT WILL BE HOUSED BY NIH AND THEIR STRIDES PROGRAM WILL BE FREELY AVAILABLE ON WHAT WE'RE CALLING A SAND BOX, NIGMS CLOUD SAND BOX SO ANY TRAINEE OR RESEARCHER CAN LOG IN AND DO THESE TRAINING COURSES, DEVELOP THEIR SKILLS IN THOSE AREAS AND ALSO LEARN THE CLOUD COMPUTING SKILLS. THIS YEAR WE'RE FUNDING TEN MORE TEAMS TO BUILD ADDITIONAL LEARNING MODULES AND THEN WE WILL ALSO DEPLOY THOSE IN THIS SAND BOX ENVIRONMENT SO THAT WILL INVOLVE PRETTY RICH EXPLORATION OF DIFFERENT KINDS OF AREAS WE THINK, GIVE DIFFERENT OPPORTUNITIES FOR PEOPLE TO LEARN THE SCIENTIFIC DATA ANALYSIS AREAS AND ALSO HOW TO WORK IN THE CLOUD ENVIRONMENT. NEXT SLIDE, PLEASE. SO THIS SLIDE JUST GIVES YOU A SENSE OF THOSE TEN MORE THAT WE'RE IN PROCESS -- OR WE HAVE FUNDED THIS WEEK ACTUALLY IN A VARIETY OF DIFFERENT AREAS, EVERYTHING FROM FUNDAMENTALS OF BIOINFOMATICS TO DATA ANALYSIS OF SPECIFIC AREAS TO SERVING DATA SCIENCE APPROACHES IN THIS CASE, ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING, VARIOUS TOOLS THERE, ET CETERA. SO IT WILL PROVIDE A RICH ARRAY OF DIFFERENT LEARNING OPPORTUNITIES AND THEY ARE BEING CONSTRUCTED BY INSTITUTIONS THROUGHOUT THE COUNTRY. NOW WE HAD THIS OPPORTUNITY OPEN TO INSTITUTIONS IN MINORITY STATES AS WELL AS MINORITY INSTITUTIONS FUNDED THROUGH THE NWIT DIVISION. WHAT YOU DO SEE HERE IS THE RESPONSE WAS VERY STRONG, FROM THE INGRAIN INSTITUTIONS, NOT NEARLY AS STRONG FROM THE OTHER ORGANIZATIONS AND I THINK IN DOES INDICATE AN OPPORTUNITY FOR US TO TRY TO STRENGTHEN UNDERRESOURCED INSTITUTIONS NOT IN IDEA STATES. ONE OF THE REASONS THE INGRAIN OPPORTUNITIES WERE SO -- NOT SURE WHAT HAPPENED TO MY SLIDES. CAN I GET THE SLIDES BACK, MATT? THANKS. IS THAT THEY ARE REQUIRED TO HAVE A DATA SCIENCE CORE, ONE OF THE REQUIREMENTS OF THE FOA. SO THAT IS SOMETHING WE NEED TO THINK ABOUT IN TERMS OF OUR SUPPORT WITH UNDERSTAND RESOURCED AND MINORITY SERVING INSTITUTIONS, IS HOW TO HELP THEM BUILD THEIR DATA SCIENCE CAPACITY IN WAYS PERHAPS MONITORING WHAT WE HAVE DONE IN THE INGRAIN PROGRAM AND MOVING THIS OPPORTUNITY FORWARD. SO WE'RE LOOKING FORWARD TO THIS IN HAVING PEOPLE USE THE MODELS THAT ARE AVAILABLE. NEXT SLIDE, PLEASE. NOW I WANT TO END BY TELLING YOU A LITTLE MORE ABOUT THE ONGOING ANALYSIS WE'RE DOING OF OUTCOMES OF THE MIRROR PROGRAM -- MIRA PROGRAM, A PARADIGM ON HOW WE CONDUCT AND SUPPORT BIOMEDICAL RESEARCH. I SHOWED YOU LAST FEBRUARY THE DATA WE HAD COME UP WITH FOR SEVERAL ASPECTS OF THE MIRA PROGRAM WITH THOSE OUTCOMES AND THAT FROM THE MATCHED INVESTIGATORS AND THE TAKEAWAYS ARE THE ESTABLISHED INVESTIGATOR, EIMIRA HOLDERS AND WHAT WE CALL THE EARLY STAGE EX-MIRA HOLDERS, PEOPLE RENEWING THEIR GRANT WITH MIRA AS WELL AS CONVERSIONS OF RO1S TO MIRAS HAD HIGHER AWARD RATES THAN THOSE TRYING TO RENEW RO1. BOTH RECEIVED BUDGETING INCREASES SO THAT WAS A BIT OF A MYTH THAT NIGMS WAS NOT GIVING INCREASES TO MIRA INVESTIGATORS, THAT WAS NOT TRUE BASED ON OUR INITIAL DATA. EX EARLY STAGE INVESTIGATORS RENEWING THEIR MIRAS AS WELL AS PEOPLE WHO HAD LOWER BUDGET MIRAS COMING IN RECEIVED THE LARGEST INCREASES ALTHOUGH MOST PEOPLE DID GET SOME KIND OF INCREASE. R01 INCREASES OVERALL, WE SHOWED YOU THOSE DATA WITH PIS THAT HAD RO1S WITH LESS THAN 250,000 IN DIRECT COSTS WERE BROUGHT UP TO AT LEAST 250,000 IN DIRECT COSTS WHICH IS KIND OF THE FLOOR WE'RE TRYING TO MAINTAIN FOR INVESTIGATORS AND PIS WITH LARGE BUDGETS IN CONVERSE AND WE DEFINE LARGE BUDGETS WITH GREATER THAN $400,000 IN DIRECT COSTS WERE GENERALLY CUT BY PERCENT AND BY 12 PERCENT AND ARE THAT ALLOWS US TO AWARD MORE PROGRAMS. AND THEY ARE NOT LOCKED IN TO THE $250,000. MOST GOT BUDGETING INCREASES, SOME OF THEM GOT FAIRLY SUBSTANTIAL BUDGETING INCREASES. SO THAT WAS WHAT I TOLD YOU LAST MEETING, JUST A SUMMARY OF THOSE DATA BUT I WANT TO TELL YOU SOME ADDITIONAL DATA ON MIRAS VERSUS RO1S NOW. NEXT SLIDE, PLEASE. SO THESE ARE ADDITIONAL QUESTIONS AND AN ANALYSIS DONE BY TRAVIS DORSEY. SO NEXT QUESTION, NEXT SLIDE, PLEASE, WAS RPI STILL APPLYING FOR MIRAS, A POPULAR PROGRAM THAT PIS ARE INTERESTED IN APPLYING FOR AND WE HAVE A STRATEGIC GOAL IT THAT IS IN OUR STRATEGIC PLAN THAT BY 2025 WE WOULD LIKE TO HAVE AT LEAST 60 PERCENT OF OUR RO1 EQUIVALENT POOL BE MIRAS. SO WE WANT TO BE A MAJORITY, A STRONG MAJORITY OF THAT POOL AS MIRAS INSTEAD OF RO1S. NEXT SLIDE, PLEASE. WE ALSO WANT TO KNOW WHAT THE DEMOGRAPHICS OF MIRAS ARE AND HOW THEY COMPARE TO THE RO1 DEMOGRAPHICS AND WHAT MAKES MIRAS MORE LIKELY TO APPLY FOR FUNDING THROUGH NIH CENTERS. SO THIS IS SOMETHING WE HAVE SEEN IN THE COMMUNITY, THAT BECAUSE MIRA PIS ARE RESTRICTED TO THAT ONE RESEARCH GRANT, IT WAS GOING TO FORCE THEM TO APPLY TO OTHER NIH CENTERS IN ORDER TO GET MORE FUNDING AND WE WANTED TO INVESTIGATE WHETHER THAT WAS TRUE OR NOT. NEXT SLIDE, PLEASE. AND FINALLY WE ALSO WANT TO KNOW HOW THE PRODUCTIVITY AND SCIENTIFIC IMPORTANCE OF M IRA PI RESEARCH COMPARE TO SIMILAR FUNDED R01PIS, SO ARE THEY DOING MORE IN TERMS OF PRODUCTIVITY, OR LESS AND THAT IS AN IMPORTANT QUESTION IN EVALUATING THIS PROGRAM AND ITS OUTCOMES. NEXT SLIDE, PLEASE. OKAY IN TERMS OF INTEREST IN MIRA, THE GRAPH HERE SHOWS FOR EIS, THE TOTAL OF PERCENTAGE AWARDS COMPRISED IN DARK SOLID BLUE, RO1, STRIPED PURPLE BARS, THOSE ARE THE MIRAS AND IN THE HASHED GREEN BARS, OTHER RESEARCH PROGRAMS OR RPGS. SO YOU CAN SEE IN 2021, AFTER STARTING FUNDING IN 2016, YOU CAN SEE THE PERCENTAGE OF MIRAS HAS BEEN STEADILY GROWING EACH YEAR, RELATIVE TO R01, GETTING CHOSE TO BEING 50 PERCENT OF THE COMPETING RPGS WE AWARDED TO ESTABLISHED INVESTIGATORS AND THEN YOU CAN SEE THE EARLY STAGE INVESTIGATORS IS EVEN MORE POPULAR AND BY 2018, A MAJORITY OF COMPETING RPGS FOR ESTABLISHED INVESTIGATORS AND THIS YEAR BEING 70 PERCENT, 2021, OF THE AWARDS WE MADE TO ESTABLISHED INVESTIGATORS WERE FROM MIRA. SO IN CONCLUSION, MIRA HAS POM AN INCREASINGLY LARGER COMPONENT OF OUR PORTFOLIO AND NOT ONLY HIGH BUT CONTINUES GROWING AND PARTICULARLY IMPORTANT AMONG EARLY STAGE INVESTIGATORS. AND MORE THAN HALF OF THE COMPETING AWARDS EACH YEAR ARE NOW MIRAS. NEXT SLIDE, PLEASE. SO IN TERMS OF DEMOGRAPHICS, FIRST COMPARING GENDER, ONE CAN SEE THAT FOR R01S, CURRENTLY ABOUT 21 PERCENT FUNDED R01S ARE FOR WOMEN PIS, 79 PERCENT ARE FOR MEN PIS, COMPARING THAT TO MIRAS, A LITTLE BIT CLOSE TO PARITY ALTHOUGH NOT A LOT OF PARITY, 27 PERCENT OF ESTABLISHED INVESTIGATORS ARE MIRAS ARE WOMEN AND 73 PERCENT REPORTING AS MEN. IN TERMS OF THE ESIS IN BOTH CATEGORIES, IT IS SOMEWHAT CLOSER TO PARITY ALTHOUGH AGAIN, STILL WE'RE NOT AT THAT 50 PERCENT LEVEL. FOR ESI R01S, 27 PERCENT WOMEN AND FOR MIRAS, ABOUT 32 PERCENT WOMEN. THIS IS ENCOURAGING, SOMEWHAT BETTER THAN THE R01 POOL BUT CERTAINLY DISCOURAGING THAT WE'RE NOT AT 50 PERCENT YET WHICH IS WHERE WE SHOULD BE IN TERMS OF THE GRADUATION DEMOGRAPHICS. NIH WIDE, I THINK SOMEWHERE BETWEEN 25-30 PERCENT IS WHAT THE DEMOGRAPHICS SHOW IN TERMS OF THE APPLICANT POOL. WE DO KNOW HAVING LOOKED AT DATA IN THE PAST THERE IS NO SIGNIFICANT DIFFERENCE EITHER FOR RO1S OR FOR MIRAS IN TERMS OF SUCCESS RATES OR SCORES BETWEEN WOMEN AND MEN SO THAT AT LEAST IS ENCOURAGING. AND THEN IN TERMS OF DEMOGRAPHICS FROM A RACIAL AND ETHNIC STANDPOINT, WE BROKE THIS DOWN IN TERMS OF STRIPED BARS BEING WHITE PIS, THE BLUE DOTTED BARS BEING ASIAN PIS, THE GREEN CROSS HASH BARS BEING HISPANIC OR BLACK AND YELLOW BEING THOSE WHO DIDN'T REPORT OR OTHER. ONE CAN SEE AS WE COMPARE THE ESTABLISHED INVESTIGATORS MIRA TO THE RO1, THAT ONLY 3 PERCENT, 4 PERCENT SELF-REPORT AS HISPANIC OR BLACK WHICH IS QUITE A BIT BELOW THE COLLEGE AGE GRADUATES OR COLLEGE GRADUATES IN LIFE SCIENCES BY SEVERAL FOLD, A NUMBER FOLD. IN TERMS OF THE EARLY STAGE INVESTIGATOR MIRA AND EARLY INVESTIGATOR RO1, MIRA IS A LITTLE BETTER AT 7 PERCENT HISPANIC OR BLACK. AGAIN, I THINK WE NEED TO INCREASE THAT NUMBER 3-4-FOLD TO GET TO THE POINT WE WOULD EXPECT BASED ON COLLEGE GRADUATION RATES IN THE LIFE SCIENCES. SO STILL MORE WORK TO BE DONE THERE, PERHAPS ENCOURAGING THAT, YOU KNOW, MIRA SLIGHTLY BETTER THAN RO1S AND THE EARLY STAGE INVESTIGATOR POOL IS A LITTLE BETTER THAN THE ESTABLISHED INVESTIGATOR POOL. WE HAVE DONE SOME PRELIMINARY ANALYSIS IN THE PAST LOOKING AT SUCCESS RATES AND SCORING AND DID NOT SEE A DIFFERENCE BETWEEN THE UNDER REPRESENTED GROUP AT THAT POINT ALTHOUGH WE'RE CONTINUING THAT ANALYSIS AND WILL REPORT BACK TO YOU WHEN WE HAVE DATA UP TO 2021 TO SHOW FOR THAT, BUT SOMETHING WE'RE CERTAINLY LOOKING AT. BUT ANY WAYS, MORE WORK TO BE DONE IN TERMS OF THE DEMOGRAPHICS, BOTH R01 POOLS AND MIRA POOLS IN THIS REGARD. NEXT SLIDE, PLEASE. SO IN TERMS OF THE MYTH THAT THE -- OR THE CONTENTION, WHICH I WILL SHOW YOU TURNS OUT TO BE A MYTH THAT THE MIRA PROGRAM AND ITS CONSTRAINTS ON GETTING ADDITIONAL NIGMS RESEARCH GRANTS WAS FORCING INVESTIGATORS TO GET FUNDING AT OTHER NIH CENTERS AND WHEN WE LOOKED AT THAT, IT TURNED OUT THAT WAS NOT WHAT SEEMS WAS HAPPENING. SO WHEN YOU LOOK AT THE GRAPH, THE SOLID PURPLE LINES THE M IRA INVESTIGATORS, THE DOTTED GREEN LINES ARE MATCHED R01 INVESTIGATORS, MATCHED IN TERMS OF HOW MUCH FUNDING THEY HAVE IN TERMS OF THEIR CAREER STAGE, DEMOGRAPHICS, ET CETERA, AND THIS IS THE PERCENTAGE OF THOSE INVESTIGATORS WHO HAD POST AWARD NET NEUTRALITY NIGMS APPLICATIONS SO APPLIED TO OTHER NIH CENTERS FOR RESEARCH GRANTS AFTER THEY GOT THEIR M IRA OR R01 AND YOU CAN SEE FOR MOST YEARS, THE MIRA INVESTIGATORS IN BOTH ESTABLISHED AND EARLY INVESTIGATOR CATEGORIES ARE APPLYING FOR FEWER APPLICATIONS -- OR GRANTS FROM OTHER NIH INSTITUTES AND CENTERS THAN WERE THE R01 INVESTIGATORS WHO WERE APPLYING FOR MORE. SO THAT IS CONTRARY TO THE MYTHOLOGY THAT IS OUT THERE THAT IT WOULD BE THE OTHER WAY AROUND AND YOU CAN READ MORE ABOUT THIS ANALYSIS IN THE FEEDBACK TO THE POST. SO THE CONCLUSION HERE, MIRA INVESTIGATORS SUBMIT COMPETING AWARDS TO ANOTHER NIH CENTERS LESS OFTEN THAN NIGMS R01 INVESTIGATORS WHICH IS COUNTER TO THE CONVENTIONAL WISDOM IN THE COMMUNITY. NEXT SLIDE, PLEASE. AND THEN FINALLY WE WANTED TO LOOK AT PRODUCTIVITY AND SCIENTIFIC IMPACT OF INVESTIGATORS AND THIS AGAIN IS LOOKING AT MIRA INVESTIGATORS VERSUS MAX COHORTS OF R01 COME PARROT TORSION, MATCHED WITH FUNDING, CAREER STAINING, ET CETERA, SO JUST YOU KNOW FROM THE INITIAL ANALYSIS FOR SIMPLICITY, WE HOOKED AT PUBLICATION RATES, CITATION RATES AND FIELD NORMAL CITATION RATES USING THE RCR METRICS AND WHAT I AM SHOWING HERE ARE THE MIRA RATES THAT ARE VERY SIMILAR TO THIS. SO WHAT IS SHOWN IN THE ESTABLISHED INVESTIGATOR MIRA, ESTABLISHED MIRA COME PARROT TORE, THE TOP TWO, OR THE BOTTOM TWO AND WE ACTUALLY -- OR TRAVIS BROKE THEM INTO EARLY COHORTS VERSUS THE LATER COHORTS BECAUSE FOR THE ESTABLISHED INVESTIGATOR COHORTS, THERE WERE DIFFERENT ELIGIBILITY REQUIREMENTS FOR THOSE WHO APPLIED FOR MIRA SO WE WANTED TO ESTABLISH THOSE COHORTS AND ALSO THEY HAD DIFFERENT LENGTHS OF TIME TO PUBLISH SO THAT BREAKS THEM INTO THE TWO DIFFERENT COHORTS. WHAT YOU CAN SEE WHEN YOU COMPARE THE CURVES PARTICULARLY FOR ESTABLISHED INVESTIGATORS IS THE MIRA COHORTS ARE SHIFTED TO THE RIGHT MEANING MORE PUBLICATIONS IN THE TIME PERIOD AND THE PERCENTILE SHOWN IN THE TOP SO THE RIGHT-SHIFTING IS ACTUALLY SIGNIFICANT WITH BOTH COHORTS BUT THE MIRA INVESTIGATORS WERE PUBLISHING MORE PAPERS IN THE TIME PERIOD THAN THE MATCHED COMPARATIVE INVESTIGATORS OF R01. IT YOU CAN SEE A LITTLE TIM LAR TREND BUT NOT MUCH OF DIFFERENCE FOR LATER COHORT TO EARLY STAGE INVESTIGATORS BUT THEY HAVE HAD VERY LITTLE TIME TO PUBLISH PARROT AND YOU CAN SEE ONLY PUBLISHED ONE OR TWO IN THE TIME THEY HAD. SO IN GENERAL I THINK THE CONCLUSION FROM THIS IS THAT THE ESTABLISHED VEST FATIVE MIRAS AND AT LEAST POTENTIALLY ONE OF THE EARLY COHORT OF EARLY INVESTIGATOR MIRAS DID HAVE HIGHER PUBLICATION RIGHTS THAN MATCHED COMPARATOR GROUPS AND AS I SAID SIMILAR TRENDS WERE SEEN WITH CITATIONS AND FIELD NORMALIZED CITATIONS USING RCR. NEXT SLIDE, PLEASE. SO THE KEY FINDINGS THERE, NEXT SLIDE, MIRA HAS BECOME AN INCREASINGLY LARGE PORTION OF OUR PORTFOLIO AND CONTINUES TO BE HIGH AMONG EARLY STAGE INVESTIGATORS. NEXT SLIDE, PLEASE. MIRAEIS A LITTLE MORE DIVERSE, BUT STILL WELL BELOW THE LEVEL FOR PH.D. GRADUATES IN LIFE SCIENCES AS WELL AS UNDER GRADUATES GRADUATING IN LIFE SCIENCES SO THIS IS AN AREA WE NEED TO CONTINUE TO FOCUS ON, BOTH TO MAKE SURE WE'RE NOT SEEING DISPARITIES IN THE LEVEL OF FUNDING BUT ALSO IMPORTANTLY TO MAKE SURE WE GET INCREASING NUMBER OF APPLICATIONS FROM RESEARCHERS FROM DIVERSE BACKGROUNDS. NEXT SLIDE, PLEASE. MIRA INVESTIGATORS HAVE SUBMITTED SUBSEQUENT APPLICATIONS AFTER THEY GOT THEIR M IRA TO OTHER NIH ICS THAN THE MATCHED GROUP OF RO1 INVESTIGATORS COUNT TO COMMON WISDOM. NEXT SLIDE, PLEASE. AND ESTABLISHED INVESTIGATIVE MIRA INVESTIGATORS SR-R SLIGHTLY HIGHER PRODUCTIVITY IN CITATIONS THAN COMPARABLE ESTABLISHED INVESTIGATOR RO1 RESEARCHERS. SO THAT, I THINK THE TAKE HOME FROM THAT WOULD PROBABLY BE MIRA FUNDED INVESTIGATORS ARE DOING AT LEAST AS WELL IN TERMS OF THEIR PRODUCTIVITY AND SCIENTIFIC IMPACT AS R01 INVESTIGATORS IF NOT SLIGHTLY BETTER SO THAT CERTAINLY SUGGESTS THAT THEY HAVE NOT, YOU KNOW, GONE OFF ON VACATION BECAUSE THEY HAVE BEEN GIVEN ADDITIONAL FREEDOM AND THEY ARE CONTINUING TO DO IMPORTANT AND IMPACTFUL SCIENCE. NEXT SLIDE, PLEASE. FINALLY I WOULD JUST LIKE TO ENCOURAGE ALL OF YOU, IF YOU HAVEN'T, TO SUBSCRIBE TO OUR FEEDBACK LOOP POST. SOME OF THE ANALYSIS I TOLD YOU ABOUT HAVE ALREADY APPEARED ON THE FEEDBACK LOOP AND MORE WILL APPEAR IN THE FUTURE SO IT IS A GOOD WAY FOR YOU TO KEEP UP WITH THE ANALYSIS, THE RESEARCH AND FUNDING AND IMPORTANT IDEAS TO GET OUT TO THE COMMUNITY AND HAVE THE COMMUNITY THINKING ABOUT. YOU CAN SUBSCRIBE IN TWO WAYS. EVERY TIME A POST COMES OUT YOU CAN GET A E-MAIL NOTIFICATION OR YOU CAN JUST GET THE DIGEST OF POSTS AFTER A NUMBER HAVE ACCUMULATED SO IT DOESN'T CLUTTER YOUR INBOX AS MUCH. SO PLEASE SUBSCRIBE YOURSELF, SUGGEST TO OTHERS THAT THEY SUBSCRIBE. I THINK THERE ARE A LOT OF MYTHS OUT THERE IN THE COMMUNITY THAT COULD BE DISPELLED MUCH MORE EASILY IF PEOPLE WOULD READ THE FEEDBACK POST LOOP AND INFORMATION WE PUT UP THERE. NEXT SLIDE, PLEASE. YOU CAN FOLLOW US ON SOCIAL MEDIA SO PLEASE DO THAT AS WELL IN ADDITION TO SUBSCRIBING TO THE FEEDBACK POST, NEXT SLIDE. AND I AM HAPPY TO TAKE QUESTIONS. SQUIRE, GO AHEAD. >> HI, JON, REALLY VERY INFORMATIVE. SO I HAVE A COUPLE OF QUESTIONS. THE FIRST ONE IS THAT YOU SAID THAT ESIS WHEN THEY RENEWED THEIR MIRA GOT BUDGET INCREASES AND UNTIL CASES, SUBSTANTIAL BUDGET INCREASES. CAN YOU SORT OF CLARIFY WHAT SUBSTANTIAL MEANS IN THAT? >> YEAH, THAT IS A GOOD QUESTION. SO THERE IS ACTUALLY A FEEDBACK LOOP POST ABOUT THAT AND WE CAN POINT YOU TO THAT, A LOT OF DATA ON THE SUBJECT. THE AVERAGE INCREASE FOR EVERYBODY WAS ABOUT 3 PERCENT. >> I GOTCHA. >> THERE WERE SOME PEOPLE WHO GOT MORE, YOU KNOW, 10 PERCENT, MAYBE AS HIGH AS 20 PERCENT INCREASES, RIGHT? >> WOW. >> SO SOME HAD THEIR BUDGET DOUBLE, SOME MAY HAVE GONE FROM 250K TO 300K FOR EXAMPLE IF THEIR PRODUCTIVITY AND WORK THEY WERE DOING REALLY SEEMED TO MERIT THAT BUDGET INCREASE. >> RIGHT. SO MY OTHER QUESTION CONCERNS THE MOSAIC PROGRAM. SO I AM ON THE STEERING COMMITTEE AND I JUST MET WITH THE SCHOLARS LAST WEEK AND THERE WERE, YOU KNOW, A NUMBER OF QUESTIONS AND SOME -- A COUPLE OF THEM CONFUSING. FIRST OF ALL WHEN THEY GO INTO R00 PHASE, RIGHT, IT IS MY UNDERSTANDING THAT THEY EACH GET $249,000 AND THAT'S TOTAL. THAT'S DIRECT PLUS INDIRECT. SO WHAT THEY ACTUALLY ARE GOING TO END UP RECEIVING DEPENDS ON WHAT THE INDIRECT IS AS THEIR INSTITUTIONS WHEN THEY GET THERE. >> I AM GOING TO DEFER THAT TO MAYBE ALISON JANNE. SO YOUR CONCERN IS IF THEY HIRE INDIRECT, THEY ARE GETTING LESS MONEY? >> EXACTLY. >> ALISON, YOU WANT TO COMMENT ON THAT? >> YES, SORRY, COMING OFF MUTE. I AM GOING TO SEE IF PENNY, ARE YOU IN THE -- WE'RE DOING A -- >> PENNY IS NOT ON, ALISON. >> SHE SAYS IT IS THE SAME AS IT FOR THE PARENT, K99 R00. AND SHE IS STILL TYPING. >> RIGHT, IT IS THE SAME OF WHATEVER THE PARENT R00 WORKS, THAT PHASE. >> BUT THE DIFFERENCE IS WHEN YOU MOVE TO THE 00, IT IS WITH A DIFFERENT INSTITUTION WITH DIFFERENT INDIRECT RATES AND SUFFICIENT LIKE THAT. I JUST ASSUMED THAT NUMBER WOULD BE DIRECT BUT IT IS NOT, IT IS DIRECT PLUS WHATEVER THE INDIRECT IS. SO WHILE THEY ARE SEARCHING FOR THAT QUESTION -- [LAUGHTER] -- I HAVE A SECOND QUESTION. SO IF THEY -- SAY THEY ARE IN THEIR R00 PHASE AND THEY GET AN R35, DO THEY HAVE TO GIVE UP THE 00? >> I BELIEVE SO, YES. I THINK WE USUALLY RUN THAT OUT FOR THE YEAR AND THEN THEY MOVE TO THE 35, YEAH. >> BUT DO YOU THINK THAT IS RIGHT? I MEAN IF YOU LOOK AT COMPARABLE PROGRAMS, FOR EXAMPLE, YOU KNOW, WHERE YOU HAVE THIS TRANSITION FOR GRANTS LIKE HANNAH GRAY, WOULD THEY HAVE TO GIVE UP THE 35? >> THAT IS AN INTERESTING QUESTION. NO, BECAUSE IT IS NOT A NIGMS -- >> THAT IS WHAT I FIGURED BUT I WOULD THINK WE WANT OUR PROGRAM TO BE ON PAR WITH OTHER PROGRAMS OR IT MAKES OURS IMFEAR. I M -- INFERIOR. >> THAT IS SOMETHING WE SHOULD THINK ABOUT. >> IS THIS SOMETHING WE CAN VOTE ON? >> WHAT'S THAT? >> IS THIS SOMETHING COUNCIL CAN DISCUSS AND VOTE ON? >> WELL, WE ARE TAKING THAT COMMENT VERY SERIOUSLY TO LOOK AT SO -- [OVERLAPPING SPEAKERS] >> RIGHT, SO THANKS SO MUCH PENNY FOR BEING ONLINE AND REMINDING ME THAT THE -- THIS IS A LITTLE DIFFERENT FROM THE RESEARCH PROJECT IN THE 8 PERCENT STANDARD AMOUNT, SO THEY GET A STANDARD AMOUNT AND IT WILL VARY ACCORDING TO THE HE HAS INSTITUTION BEFORE THEY TRANSITION TO THE 00S. >> THE PERCENT IS THE SAME. >> SO IT DOESN'T VARY AND THIS IS NIH-WIDE POLICY AND SO WE'RE JUST FOLLOWING ALL OF THE NIH-WIDE POLICIES. WE WILL CERTAINLY TAKE THINGS INTO CONSIDERATION AND I THINK ANY POLICY WE MAKE FOR MOSAIC WOULD HAVE TO BE CONFIGURED ALL THE WAY THROUGH NIH. AND LET'S SEE, KENNY -- WOW, HE IS GIVING A LOT -- [LAUGHTER] LET'S SEE. SORRY, YEAH. NO, AT ANY RATE, I THINK WE CAN CERTAINLY GET BACK TO YOU. I AM GOING TO HAVE TO HAVE MAYBE A SIDE CONVERSATION WITH PENNY AND COME BACK TO -- >> OKAY, WE WILL COME BACK TO YOU. >> THANK YOU, SORRY ABOUT THAT, OKAY. >> DANIELLE? >> SO I HAVE TWO QUESTIONS, ONE IS MORE LIKE A SOAP BOX STYLE QUESTION/COMMENT AND THE OTHER IS A LITTLE MORE SPECIFIC. SO SORT OF ON THE SOAP BOXING I WAS THINKING OF THESE MIRA AND CONVERSION RATES WHICH WE TALKED ABOUT LAST TIME AND THEY ARE QUITE HIGH AND THE QUESTION I HAD LAST TIME WHICH I KIND OF WANT TO PUSH AGAIN AS RELATED TO THIS IS WE HAVE BEEN SPENDING A LOT OF OUR CONVERSATIONS TALKING ESSENTIALLY ABOUT THINGS RELATED TO THE PIPELINE ISSUES AND ALSO THE VP PIPELINE ISSUES ARE ABOUT DEMOGRAPHICS SO LIKE MINORITIES SEEKING OUT MORE AND THAT KIND OF UNDERLINES THE PHILOSOPHY BEHIND ALL OF THESE DISCUSSIONS IS THAT WE WANT TO PLUG IN THESE BUT IN A BROAD WORLD SENSE, WE DON'T WANT THE PIPELINE TO LEAK AT ALL, WE JUST DON'T WANT IT TO DIFFERENTIALLY LEAK. LIKE EVERY KID THAT ENTERS SAOEUBZ SCHOOL CLASS SHOULD NOT END UP BEING LIKE A NIH FUNDED INVESTIGATOR. AND SO MY SORT OF BROADER POINT IS IT SHOULD BE EASY TO ANALYZE WHERE WOMEN LEAK MORE OR WHAT THE DIFFERENCE IS ACROSS DEMOGRAPHIC GROUPS BECAUSE THAT IS MORE AMENABLE TO THE ANALYSIS. BUT ONE OF THE QUESTIONS I FEEL I HAVE LESS CLARITY ABOUT IS WHAT THE NIH AND NIGMS THINKS ABOUT AS LEAK CAGE FROM ONE PART TO THE OTHER. SO THE RENEWAL RATE SHOULDN'T BE 0 BUT SHOULDN'T BE 100 PERCENT BECAUSE 100 PERCENT IS EITHER TOO PICKY AND NOT GIVING PEOPLE MUCH OPPORTUNITY AND THEN THE R01 PERCENT IS WHERE PEOPLE ARE JUST GETTING FUNDED AND FUNDED AND FUNDED. SO IS THERE SOME THOUGHT -- I MEAN WHAT I SAW WAS LIKE 70 PERCENT OR SOMETHING, VERY HIGH RATE AND YOU WOULDN'T WANT TO -- LIKE WE DON'T TAKE OUT 25 PERCENT GRADUATE SCHOOL PROGRAMS SO LIKE 75 PERCENT SHOULD BE HIGHER BUT YOU WOULDN'T KEEP 75 PERCENT OF THE PORTFOLIOS FROM ONE PAGE TO THE NEXT AND SO LIKE WHAT ARE THE THOUGHTS ABOUT WHAT SORT OF IS THE RIGHT LEVEL ON AVERAGE FOR EVERYONE BEFORE WE THINK ABOUT WOMEN VERSUS MINORITIES ARE SORT OF DIFFERENTIALLY DIFFERENT ON THAT LEVEL. >> I THINK IT IS AN EXCELLENT QUESTION. THE FRAMEWORK YOU LAYOUT IS ONE OF THE THINGS THAT THE M IRA PROGRAM ALLOWS, RIGHT, BECAUSE IF PEOPLE ARE FUNDED BY BASICALLY ONE NIGMS GRANT AND THE FUNDING THAT SUPPORTS THEIR LAB, IT SIMPLIFIES THE SYSTEM BECAUSE THEIR IN-FLOW AND OUTFLOW, WHAT YOU ARE SAYING, YOU DON'T HAVE MULTIPLE GRANTS WHICH WOULD COMPLICATE THAT ANALYSIS. >> ONE OF THE THINGS THAT WAS STRIKING WHEN YOU WERE LOOKING AT THE ANALYSIS, YOU WERE SORT OF COMPARING LIKE MIRA VERSUS NONMIRA WITHIN ESTABLISHED AND THEN SEPARATELY EARLY STAGE INVESTIGATORS BUT THE COHORT WHEN YOU LOOKED AT THAT GROUP, LOOKS LIKE THE ESTABLISHED INVESTIGATORS WERE PUBLISHED AS MUCH AS EARLY INVESTIGATORS SO CONSIDERING ESTABLISHED AND NONESTABLISHED AND IT SEEMS AS THOUGH ONE WAY TO DO READ THAT DATA IS THERE IS TOO MANY EARLY STAGE INVESTIGATORS. >> WE WOULD HAVE TO GO BACK AND LOOK AT THE DATA AND I THINK THEY ARE SHIFTED OFF OF EACH OTHER BUT TO YOUR EARLIER POINT, THERE NEEDS TO BE A OUTFLOW, IF YOU WILL, AND THAT IS ABSOLUTELY TRUE. YOU CAN'T -- IF THERE WAS A 100 PERCENT RENEWAL RATE, THAT CANNOT BE A HEALTHY SYSTEM BECAUSE HOW COULD YOU HAVE ANYONE COMING INTO THE SYSTEM? SO AT SOME LEVEL THE OUTFLOW RATE NEEDS TO MATCH THE RATE YOU WANT NEW PEOPLE COMING INTO THE SYSTEM, THE PRIMARY GROUP COMING IN AS NEW, RIGHT, UNLESS YOU HAVE SIGNIFICANT AMOUNTS OF NEW FUNDING TO INCREASE THE SIZE OF THE POOL. RIGHT? SO THOSE ARE THE PARTS OF THE EQUATION WE'RE TRYING TO BALANCE OF CAN I GIVE YOU THE EXACT NUMBER OF WHAT THE OUTFLOW RATE NEEDS TO BE. WE HAVE MODELED IN THE PAST BUT THERE ARE A LOT OF VARIABLES TO TRY TO UNDERSTAND WHAT EXACTLY IT SHOULD BE. I THINK YOU ARE RIGHT, 100 PERCENT OBVIOUSLY -- OR ZERO PERCENT ATTRITION IS NOT AT ALL HEALTHY AND NOT GOING TO WORK. 30PERCENT A YEAR, I MEAN -- [OVERLAPPING SPEAKERS] -- TOO HIGH WHEN YOU ARE TALKING ABOUT PEOPLE WHO HAVE GONE THROUGH A LOT OF VETTING TO GET TO THE STAGE THEY ARE AT, RIGHT, YOU KNOW, THEY GOT DEGREES, THEY GOT HIRED BY ACADEMIC INSTITUTIONS, THEY THEN WERE SELECTED TO GET A GRANT WITH THIS PEER REVIEW PROCESS, SO SOMEWHERE BETWEEN THOSE TWO NUMBERS, I THINK, IS THE RIGHT NUMBER. >> OKAY. >> BUT EXACTLY WHAT IT IS MAY BE YOU BEING INTERESTED IN MODELING, RIGHT? IT IS A REALLY GOOD QUESTION. WHAT DO YOU NEED THE RATE OF PEOPLE LEAVING TO BE TO HAVE THE SYSTEM HEALTHY? >> YEAH, AND I THINK THAT IS LESS ABOUT GETTING THE NUMBERS MATCHING ON THE INSIDE AND THE OUTSIDE, IT IS MORE LIKE PEOPLE SHOULD LEAVE ONCE THEIR RESEARCH POTENTIAL IS REVEALED AS OPPOSED TO LOWERING THE OPPORTUNITY. >> AND IT SOUNDS VERY HARSH TO SAY THAT BUT I THINK ONE OF THE THINGS WE HAVE TO RECOGNIZE IN THE PARADIGM OF MIRA PROGRAM IS ALTHOUGH WE'RE TRYING TO MAKE THINGS MUCH MORE STABLE FOR INVESTIGATORS, I THINK AT THE SAME TIME, THE LEAVING PART IS PROBABLY GOING TO BE MORE FINAL. >> YEAH, I MEAN I THINK -- >> IT SHOULD BE RO1 PARADIGM, YOU KEEP APPLYING AND YOU ARE BOPPING IN AND OUT OF THE SYSTEM ALL THE TIME AND THAT IS PROBABLY NOT A VERY HEALTHY PARADIGM FOR ANYBODY. >> YEAH, AND THE SECOND SORT OF PROXY POINT, YOU ARE MAKING THESE MODULES AND PEOPLE WATCH THESE BUT I FEEL A LOT OF TIMES, LIKE WHEN I THINK OF MYSELF AS A ENGINEER, THERE IS THIS LOOMING TRANSITION FOR OVERFLOW SO PART ONE OF THE QUESTION IS, IS THERE SOME STACK OVERFLOW FOR THESE SORT OF CLOUD COMPUTING APPLIES TO LIFE SCIENCE ISSUES AND ARE THERE WAYS TO LIKE CREATE RESOURCES THAT GET PEOPLE TO BE MORE EFFICIENT INDEPENDENT GOOGLERS? >> GOOGLERS, IS THAT YOUR -- >> LIKE PROGRAMMING DATA COUNT, JUST TO GET BETTER AT GOOGLING WHAT I NEED INSTEAD OF RIGHT NOW I CAN'T GOOGLE ANYTHING BECAUSE I DON'T KNOW WHAT I NEED AND HOW TO PROCESS IT. SO ANOTHER WAY TO KEEP IN MIND WHAT ARE THE RESOURCES OUT THERE AND CAN WE GET PEOPLE TECHED UP TO A POSITION WHERE THEY BECOME MORE INDEPENDENT IN LOOKING FOR SOLUTIONS? >> GOOD QUESTION. PART OF THE SAND BOX APPROACH IS THAT THEY WILL ACTUALLY INCORPORATE POSITIONS ON THINGS YOU WILL WATCH, INCORPORATE HANDS-ON WHERE PEOPLE WILL BE I GUESS WRITING CODE AND THINGS LIKE THAT TO SEE HOW IT WORKS, SO THEY WILL BE GETTING FAMILIAR. WHERE WE LIKE TO EXPAND INTO MORE THAN THAT, THERE IS REAL DATA SETS THEY ARE LINKED TO AND THEN THEY ARE ACTUALLY TRYING TO DEVELOP WAYS TO PROCESS THE DATA AS THEY ARE LEARNING, RIGHT? SO KIND OF MORE WHAT YOU ARE SAYING, IS LIKE YOU KNOW TESTING OUT YOUR OWN IDEAS AS PART OF THE LEARNING PROCESS IN A ENVIRONMENT THAT ALLOWS YOU TO DO, YOU KNOW, "EXPERIMENTS", IF YOU WILL, AND SEE IF IT WORKS. SO THAT IS WHERE WE WOULD LIKE TO HEAD AS AN INTERMEDIATE STAGE WHERE THEY WILL HAVE THE ABILITY TO DO SOME OF THAT BUT IN A MORE CONTROLLED WAY LIKE WHAT YOU ARE SAYING, TESTING OUT TO SEE WHAT WORKS. IN TERMS OF FINDING THE RESOURCES YOU NEED, ABSOLUTELY. YOU KNOW I THINK THERE ARE A LOT OF RESOURCES OUT THERE ALREADY THAT PEOPLE COULD FIND BUT WE'RE TRYING TO CREATE MORE THAN ARE TARGETED TO THE SCIENTIFIC THINGS THAT THEY ARE DOING. I THINK ONE OF THE THINGS WE HEARD WAS THERE ARE RESOURCES THAT ARE VERY GENERIC BUT TO THE THING YOU WANT TO DO SPECIFICALLY THAT IS SCIENTIFIC, IT IS HARD TO MAKE THE TRANSITION FROM THE GENERIC ONE TO THE MORE SPECIFIC ONE. SO WE'RE TRYING TO BRIDGE THAT GAP AS WELL. >> THANK YOU SO MUCH. >> THANKS, DAVID? >> THANKS, I WANTED TO ASK A LITTLE BIT MORE ABOUT THE CLOUD COMPUTING WHICH I THINK IS A REALLY NICE INITIATIVE. AND IN PARTICULAR, I AM CONCERNED IN A YOU HAVE THE NICE TRAINING MODULES THAT WILL GET PEOPLE INTO THE RESEARCH BUT THEN THE NEXT BARRIER IS PAYING FOR THE CLOUD COMPUTING COSTS. >> RIGHT. >> AND SOMETHING WE HAVE TALKED ABOUT IS WHETHER THERE COULD BE A ADMINISTRATIVE VIEW OF GRANTS THAT COULD BE PROVIDED TO INVESTIGATORS TO DO THE NEXT PHASE TO COVER THE CLOUD COMPUTING COSTS AND IS THAT ABLE TO BE WORKED ON AND THOUGHT ABOUT? >> YES, I THINK IT IS MORE COST EFFECTIVE VERSUS WHAT IS SAFE. SO PART OF THIS PILOTING WE'RE DOING IS TO SEE HOW DO WE GET THE GUARDRAILS IN PLACE, IS IT MORE EFFECTIVE FOR US TO, YOU KNOW, SOMEHOW PAY THE CLASSIFIER UPFRONT WITH A CERTAIN AMOUNT AND THEN METER THAT OUT FOR DIFFERENT PEOPLE TO USE, IS IT MORE EFFECTIVE TO GIVE MONEY TO PEOPLE IN THEIR GRANTS OR YOU ARE SAYING IT IS SUPPLEMENTAL OR ADDITIONAL GRANTS SO YOU ARE ASKING THE RIGHT QUESTIONS. I THINK WE DON'T KNOW THE RIGHT ANSWERS YET AND THAT IS WHY WE'RE TRYING TO DO THESE PILOTS TO FIGURE OUT THE BEST WAY TO DO IT. >> IT SEEMS TO ME IF NIH AND NIGMS CAN BUY THE TIME AND DOLE IT OUT TO INVESTIGATORS, THAT SEEMS LIKE THE MORE COST EFFECTIVE APPROACH. >> IT MAY BE. WE'LL SEE. AND THAT'S WHAT THIS MODEL ON SOME LEVEL IS EXPLORING, RIGHT? BUT DOES THAT SCALE, RIGHT? I MEAN FOR A SMALL NUMBER OF USERS, LIKE TRAINEES, IT MAY WORK. BUT IF YOU ARE TALKING ABOUT, YOU KNOW ACTUAL PEOPLE DOING REAL COMPUTING INTENSIVE RESEARCH WHERE THEY ARE GOING TO BE USING A LOT OF COMPUTING TIME, THAT MAY NOT SCALE AND YOU MAY HAVE TO DO IT A DIFFERENT WAY. SO IT MAY NOT BE ONE SIZE FITS ALL FOR EVERY KIND OF THING YOU ARE TRYING TO DO. >> I IMAGINE BECAUSE OF THE DEM MOSTCRATIZATION IDEA AND TRYING TO HELP OUT INVESTIGATORS IN IDEA STATES, MANY OF THEM PROBABLY DON'T HAVE A HUGE REQUIREMENT FOR COMPUTING AND SO -- BUT IT STILL REPRESENTS A BARRIER SO I THINK MAYBE TARGETING TO INVESTIGATORS, YOU KNOW, WHO NEED THAT ADDITIONAL HELP, ARE IT MAY NOT COST A LOT BUT WOULD REALLY OPEN OUT UP THE ABILITY TO DO NICE RESEARCH. >> YES, GREAT POINT, THANK YOU. >> THANKS. >> NATALIE? >> WELL, I JUST WANTED TO GIVE YOU SOME FEEDBACK FROM INVESTIGATORS I HAVE BEEN TALKING TO ABOUT MIR AV. IT IS BROADLY SUCCESSFUL, VERY BROADLY VIEWED AS BEING ONE OF THE MOST STABILIZING FORCES FOR BASIC SCIENCES. BUT IT IS VERY -- MOST OF THE DISCUSSIONS I HAVE ARE PEOPLE TRYING TO FIGURE OUT HOW TO GET INTO THE SYSTEM GIVEN THAT THEY -- AND SO TO THE EXTENT THAT YOU WANT TO INCREASE THE NUMBER OF ESTABLISHED MIRA INVESTIGATORS, YOU KNOW, SOME SORT OF WAY TO ALLOW PEOPLE WHO PREVIOUSLY HAD R01S AND WHO ARE IN THE AREA OF BASIC SCIENCES TO QUALIFY FOR APPLICATION AND ONE SPECIFIC EXAMPLE I SAW WAS AN INVESTIGATOR WHO HAD ACTUALLY MADE IT TO NIGMS R01S BUT THEY WERE MPIS AND EXCLUDED FROM APPLYING AND IT WAS SORT OF LIKE -- HE SAW IT AS A CATCH-22 BECAUSE THE REASON HE SET IT UP AS A MPI IS HE THOUGHT NIH WANTED THE COLLABORATION AND THEN GOT BITTEN IN THE BUTT BECAUSE ALL OF HIS GRANTS WERE DENIED. SO I DON'T KNOW WHETHER THERE'S A MECHANISM TO DEAL WITH THAT. MY SUGGESTION TO HIM WAS DURING THE NONCOMPETITIVE AS A RULE, CHANGE HIS STATUS AND I DON'T KNOW IF THAT IS A DO BELIEVE THING BUT IT PRECLUDED HIM FROM ENTERING THE MIRA PROGRAM. >> THANK YOU VERY MUCH, THAT IS CERTAINLY AN ISSUE, THE MPIS WE RECOGNIZE. THEY DO MAKE THINGS COMPLICATED FOR US BECAUSE WHAT DO YOU DO ABOUT THE MPI INVESTIGATORS -- YOU KNOW, WOULD WE DID HAVE A ROUND WHERE WE WERE CONVERTING THEM TO MIRAS AND THEN REALIZED THAT WOULD BE MUCH TOO COMPLICATED BECAUSE THERE WERE THE OTHERS WHO DIDN'T GET M IRA GRANTS AND DO WE GIVE ALL THE MONEY TO THEM AND INCREASE COSTS IN A WAY THAT ISN'T NECESSARILY RIGHT SO WE WILL KEEP WORKING ON THAT. AND IN TERMS OF GETTING NEW PEOPLE IN THE SYSTEM, COMPLETELY AGREE. YOU MAY RECALL WE ARE EXPANDING ELIGIBILITY IN THE NEXT ROUND TO INCLUDE NEW INVESTIGATORS SO THAT WON'T GET AT THE POOL YOU MENTIONED OF PEOPLE WHO PREVIOUSLY HAD GRANTS BUT IT WILL, WE HOPE, DIVERSIFY THE POOL SO PEOPLE WHO AREN'T ESIS BUT HAVE NOT HAD A MAJOR NIH GRANT WILL BE ELIGIBLE. >> AND I CAN SEE THE HESITATION BECAUSE SORT OF OPENING IT UP FURTHER ALLOWS PEOPLE WHO ARE DOING -- [GARBLED] JUMP IN AND THEN PUSH IT OUT TO BASIC SCIENCES. I DON'T KNOW, MY SUGGESTION MIGHT BE TO IDENTIFY THOSE WHO ARE IN THAT SITUATION OF HAVING 100 PERCENT MPI GRANTS AND OPEN IT UP FOR DISCUSSION ON HOW IT MIGHT BE DONE. >> THANK YOU TO ARE THAT AND THE LAST WORD TO ALISON. >> MY APOLOGIES, I MISSPOKE EARLIER SO THE 8 PERCENT INDIRECT COSTS IS FOR THE F -- FOR THE -- [INDISCERNIBLE] , R00 USER DIRECT COSTS ARE INSTITUTIONAL SO WHEN THEY SUBMIT A TAILED BUDGET AT THE TIME OF THE TRANSITION, TYPICALLY THIS TRANSLATES INTO 100 TO $150,000 FOR DIRECT COSTS. WE WILL CERTAINLY TAKE BACK YOUR COMMENT TO NIH CENTRAL WHICH IS WE DON'T HAVE ANY CONTROL OVER THIS POLICY ABOUT HOW THIS CAN CAUSE DISCREPANCY ACROSS INSTITUTIONS DEPENDING ON WHERE THE INDIVIDUAL TRANSITIONS SO THAT IS A GOOD POINT. IN TERMS OF THE JUST TYPICALLY WHEN SOMEBODY DOES GET A RESEARCH PROJECT GRANT, IT TENDS TO HAPPEN IN THE FINAL YEAR OF THE -- OF THE R00 SO THAT THEY ARE ABLE TO FINISH IT OUT AND TRANSITION TO THE -- SO THAT IS MOSTLY HOW IT HAPPENS ON THE WHOLE. SO I -- THERE MIGHT HAVE BEEN A FEW MORE QUESTIONS I MISSED AND I REALLY APOLOGIZE, I AM SORT OF GOING BACK AND FORTH. SO DOES THAT ANSWER ALL OF YOUR QUESTIONS? I KNOW THERE ARE CONCERNS THAT ARE UNADDRESSED BUT WE CAN TAKE THOSE CONCERNS BACK TO NIH. >> YEAH, I JUST WANTED A CLARIFICATION ON THE INDIRECT RATE ONCE YOU GET TO R00. SO IT SOUNDS LIKE I AM CORRECT THAT -- >> YEAH, YOU ARE CORRECT, YEAH. >> IT IS VERY SPECIFIC DEPENDING ON WHAT YOUR SNA IS WILL DEPEND ON HOW MUCH MONEY YOU WILL GET BECAUSE YOUR TOTAL COST CANNOT BE MORE THAN $249,000 AND ANOTHER ISSUE I THINK YOU GUYS SHOULD CHECK ON IS WHETHER PEOPLE IN THE R00 HAVE TO GIVE UP THE R -- HAVE TO GIVE UP THE -- PEOPLE WHO APPLY AND GET AN R35 IF THEY HAVE TO GIVE UP THE R00. THAT CAUSES CONFUSION AMONG THE MOSAIC SCHOLARS BECAUSE THEY DON'T KNOW WHEN THEY ARE SUPPOSED TO APPLY FOR THE R35, YOU KNOW? >> SURE. >> BECAUSE THEY THINK THEY ARE GIVING UP MONEY. >> RIGHT, GOT IT, SO I CAN TAKE THAT -- THAT IS ON US, WE REALLY NEED TO BETTER ADVERTISE THAT, HOW TO DO THOSE TRANSITIONS AND WHEN TO APPLY AND ALSO SORT OF WHICH CYCLES TO COME IN. SO THAT IS SOMETHING WE CAN COMMUNICATE A LITTLE BETTER -- >> BUT I THINK THE EASIEST THING IS JUST TO LET THEM FINISH OUT THE R00, KEEP THE MONEY, LIKE HANNAH GRAYS AND OTHER TYPES OF SKILLS AND WE DON'T WANT THE PROGRAMS TO BE LOW RISK, YOU WANT IT ON PAR AS THE OTHER PROGRAMS SO THAT IS MY POINT. >> GREAT POINT. THANK YOU, SQUIRE. OKAY WE'RE GOING TO MOVE ON NOW AND THANK YOU FOR THAT VERY RICH DISCUSSION. I THINK THAT WAS, AS ALWAYS, VERY USEFUL. SO WE'RE GOING TO MOVE ON TO CONCEPT CLEARANCES AND WE HAVE QUITE THE NUMBER OF THEM AND I AM GOING TO START WITH THE ONES THAT ARE JUST REISSUANCES OF CURRENT PROGRAMS WITH MINOR OR NO CHANGES AND ERICA, SHOULD WE TAKE A VOTE AFTER EACH ONE OR AT THE END? >> I WILL NEED TO GET A VOTE ON EACH ONE. >> OKAY, NEXT SLIDE, PLEASE. OKAY, FIRST ONE IS A PROGRAM YOU HAVE ALREADY HEARD ABOUT. SCIENCE EDUCATION PROGRAM AWARDS, SUPPORTS PRE-K THROUGH 12 CLASSROOM BASED AND INFORMAL SCIENCE ACTIONIVITY TO ENHANCE THE DIVERSITY OF THE BIOMEDICAL RESEARCH WORKFORCE AND FOSTER A BETTER UNDERSTANDING OF BIOMEDICAL RESEARCH FUNDED BY NIH. THERE ARE SEVERAL HIGH PROGRAM AREAS TO S EPA THIS PERIOD. FIRST IS EDUCATIONAL PROGRAMS THAT PROVIDE ACCESS TO RESEARCH GENERATED DATA TO TRAIN STUDENTS IN THINGS YOU WERE TALKING ABOUT BEFORE, INFORMATICS, BIOINFORMA TICS AND DATA SCIENCE CAREERS, PROJECTS WITH EMBEDDED MATH AND READING CONTENT FOR P-8 STUDENTS AND ADAPTATIONS OF SUCCESSFUL SEPA PROGRAMS IN NEW LOCATIONS OR POPULATIONS. THERE ARE ONLY A FEW MAJOR CHANGES FROM FOA, ONE I TOLD YOU ABOUT THAT THEY INCORPORATE OTHER NIH CENTERS AND OFFICES THAT MAY PARTICIPATE IN FUNDING APPLICATIONS. SO ANY QUESTIONS ON THAT? DON'T SEE ANY, ERICA, YOU WANT TO CALL FOR THE VOTE? >> I MOVE WE APPROVE THE CONCEPT FOR FURTHER DEVELOPMENT OF FOA. ARE ANY OPPOSED? AND FOR VOTING, WE ASK YOU RAISE YOUR HAND USING THE ZOOM MODULES SO WE CAN SEE IT. OKAY IT, LOOKS LIKE THE MOTION IS UNANIMOUSLY APPROVED -- OH WAIT, WE HAVE A COMMENT FROM PAUL. >> NO, SORRY, I WAS JUST VOTING. >> THE HAND RAISE IS TO OPPOSE, TO KEEP IT SIMPLE. THANK YOU. >> SO ARE YOU OPPOSING OR VOTING FOR? >> I AM VOTING FOR, SORRY. >> SO I WILL CONCLUDE AGAIN, THE MOTION IS UNANIMOUSLY APPROVED, THANK YOU. >> THANK YOU, NEXT SLIDE, PLEASE. THEN THE SECOND ONE IS AN ACOMPLIMENT TO THE MAIN SEPA PROGRAM WHICH IS THE SMALL BUSINESS PORTION OF SEPA WHICH IS AN SIR AND SDIRFOA, IT PROVIDERS OPPORTUNITIES FOR ELIGIBLE SMALL BUSINESS CONCERNS TO DEVELOP INTERACTIVE DIGITAL MEDIA SCIENCE, TECHNOLOGY, ENGINEERING AND MATH MATHEMATICS, PRODUCTS THAT ADDRESS STUDENT CAREER CHOICE AND HEALTH AND MEDICINE TOPICS. TRANSLATION OF NEW OR EXISTING HEALTH AND MEDICINE-BASED STEM CURRICULA INTO EDUCATIONAL IDM PRODUCTS THAT WILL PROVIDE HANDS-ON AND LEARNING BY EXPERIENCES FOR PRE-K TO GRADE 12 AND GENERAL PUBLIC. NO SPWAPBTIVE CHANGES FROM PREVIOUS FOA. ERICA? >> ARE THERE ANY OPPOSED TO THE MOTION? RAISE YOUR HAND IF YOU ARE OPPOSED. IT IS EASIER TO CAPTURE IT THIS WAY. THANK YOU, THE MOTION IS UNANIMOUSLY APPROVED. >> NEXT SLIDE, PLEASE. AND THEN WE HAVE THE RENEWALS OF OUR PREDOCTORAL INSTITUTIONAL TRAINING AWARDS AND ARE THERE ARE TWO FLAVORS OF THOSE, THE MAIN ONE WHICH ARE THE BIOMEDICAL ONES ALLOWING GRANTEES TO GET FUNDING IN BIOMEDICAL PROGRAMS AND THEN THERE IS THE DUAL DEGREE SCIENTIST TRAINING PROGRAMS. THE PURPOSE OF BOTH PROGRAMS IS TO DEVELOP A DIVERSE POOL OF WELL TRAINED SCIENTISTS TO MEET THE NATION'S BIOMEDICAL RESEARCH NEEDS AGENDA. THEY SUPPORT ELIGIBLE DOMESTIC INSTITUTIONS TO DEVELOP APPROACHES FOR BIOSCIENCE TRAINING AND THE GOAL IS TO KEEP PACE WITH RAPID EVOLUTION TO THE ENTERPRISE AND DON'T JUST KEEP USING THE SAME MODEL BUT H*EUPB KNOW STATE AND EXPLORE NEW AND OPTIMIZED MODELS AS THE SITUATION EVOLVES. WE EXPECT THE TRAINING PROGRAMS TO INCORPORATE DIDACTIC RESEARCH AND CAREER DEVELOPMENT ELEMENTS THAT PREPARE TRAINEES FOR CAREERS THAT WILL HAVE SIGNIFICANT IMPACT ON THE HEALTH RELATED RESEARCH AND NEEDS OF THE NATION AND THAT IS THAT THEY DON'T JUST PICK GOOD STUDENTS BUT TRAIN THEM IN WAYS TO MAKE THEM MORE EFFECTIVE RESEARCHERS. THE CHANGES THEY ARE PROPOSING ARE MINOR AND JUST TO ALIGN THE T32'S WITH OUR OTHER TRAINING FOAS, SPECIFICALLY THE RECRUITMENT PLAN TO ENHANCE DIVERSITY AND THE TRAINING AND RESPONSIBLE PRODUCT RESEARCH PLAN FOR SCORE DRIVING. IN THE PAST THEY WERE COMMENTED ON AS ACCEPTABLE OR NOT ACCEPTABLE BUT NOW WILL BE SCORE DRIVING WHICH WE ARE DOING IN OTHER PROGRAMS AND ACTUALLY SOMETHING THE COMMUNITY HAS BEEN PRESSING US TO DO SO THIS IS GOING ALONG WITH COMMUNITY INPUT. SO ANY COMMENTS ON THOSE? OKAY, DON'T HEAR ANY SO ERICA? >> I MOVE WE APPROVE THE COPS SEPTEMBER FOR FURTHER DEVELOPMENT OF FOA. ARE ANY OPPOSED? I I THINK THE MOTION IS UNANIMOUSLY APPROVED. THANK YOU. >> NEXT SLIDE. NOW WE HAVE A CONCEPT CLEARANCE FOR A NEW PROGRAM AND ACTUALLY NOT A NIGMS PROGRAM BUT A PROGRAM COMING OUT OF THE UNITE E COMMITTEE WHICH I MENTIONED PREVIOUSLY, THE PART OF UNITE THAT IS FOCUSING ON THE EXTRAMURAL ECOSYSTEM AND COMBATING STRUCTURAL RACISM IN THAT ECOSYSTEM AND THE UNITE E COMMITTEE IS CO-CHAIRED BY MYSELF, ERICA BOONE AND AND ORDONEZ. SO JUST TO REMIND YOU, NEXT SLIDE PLEASE, THE COMMITTEE HAS THREE DIFFERENT -- OR FOUR DIFFERENT WORKING GROUPS OR COMPONENTS. THE ONE WE ARE TALKING ABOUT TODAY IS LOWER LEFT, RESEARCH AND CAPACITY BUILDING AT MINORITY INSTITUTIONS. NEXT SLIDE, PLEASE. SO I THINK NO ONE WILL ARGUE, I DON'T THINK, WITH THE FACT THAT CUTTING-EDGE INSTRUMENTATION IS ESSENTIAL FOR AN INSTITUTION TO BE ABLE TO CONDUCT BIOMEDICAL RESEARCH AND BIOMEDICAL RESEARCH TRAINING SO THIS REPRESENTS A SIGNIFICANT BARRIER BECAUSE, YOU KNOW, PURCHASING AND MAINTAINING THAT EQUIPMENT AND OPERATING THAT EQUIPMENT IS OFTEN NOT SOMETHING THAT THEY HAVE THE RESOURCES IMMEDIATELY TO DO. AND SO THE COMMITTEE FELT THIS WAS AN IMPORTANT OBSTACLE TO ENHANCING THE RESEARCH AND THE RESEARCH TRAINING ENVIRONMENT AT UNDER RESOURCED INSTITUTIONS AND PARTICULARLY UNDERRESOURCED MINORITY SERVING INSTITUTIONS. NEXT SLIDE. SO NIH RECENTLY STARTED A PROGRAM WHICH IS CALLED THE BASIC INSATION GRANT S-10 PROGRAM AND USES THE S-10 ACTIVITY CODE WHICH IS OPEN TO INSTITUTIONS INCLUDING LOWER-RESOURCED MINORITY SERVING I BELIEVE SO R INSTITUTIONS AND THE HOPE WAS THAT IT WOULD INCREASE THE NUMBER OF S-10 EQUIPMENT GRANTS THESE KIND OF INSTITUTIONS COULD COMPETE FOR. THIS IS MANAGED BY ORIP, A LIMITED COMPETITION SO IT IS ONLY OPEN TO INSTITUTIONS THAT HAVE NOT RECEIVED 110 GRANTS -- 110 GRANTS OVER $250,000 IN THE PAST THREE YEARS, THE AWARDS RANGE 25,000 TO 250,000, A GROUP OF THREE MAJOR USERS MUST BE MAINTAINED WITH AN ACTIVE NIH RESEARCH AWARD. THAT IS A BARRIER TO MANY UNDER RESOURCED INSTITUTIONS WHO WANT TO USE A SPECIFIC PIECE OF EQUIPMENT, ALL MUST HAVE AN ACTIVE NIH RESEARCH GRANT. AND IN ADDITION, MAJOR USERS SHOULD USE THE INSTRUMENT 25 PERCENT OR GREATER OF ACCESSIBLE USER TIME SO THEY HAVE TO BE VERY HEAVY USERS OF THIS EQUIPMENT. NEXT SLIDE, PLEASE. SO IF YOU LOOK AT THE DATA SO FAR, KIND OF A NEW PROGRAM BUT SO FAR FROM 2019 TO 21, ONLY SIX ORIP AWARDS GIVEN TO MINORITY SERVING INSTITUTIONS THAT HAD LESS THAN $25 MILLION IN NIH RESEARCH PROJECT GRAND FUNDS SO THAT IS ONLY 1.6 PERCENT OF ALL S-10 AWARDS AND ARE LESS THAN A THIRD OR APPROXIMATELY A QUARTER OF S-10 AWARDS THAT WENT TO MINOR SERVING INSTITUTIONS, THOSE LESS THAN 25 MILLION IN R RPG FUNDING AND I WILL POINT OUT 28 PERCENT IS QUITE A SUBSTANTIAL AMOUNT SO INSTITUTIONS THAT ARE NOT ALREADY FAIRLY WELL ESTABLISHED IN GETTING NIH FUNDING, NOT GETTING MANY EQUIPMENT GRANTS FROM NIH TO SUPPORT THE BUILDING OF THAT RESEARCH CAPACITY AND INFRASTRUCTURE AND RESEARCH TRAINING INFRASTRUCTURE. AND SO BASED ON THIS, THE GROUP FELT THAT A TARGETED PROGRAM WOULD ENCOURAGE APPLICATIONS FROM LOWER RESOURCED MINORITY SERVING INSTITUTIONS AND HELP THEM BUILD THEIR RESEARCH CAPACITY AND THAT IN TURN WILL HELP ENHANCE RESEARCH AND EDUCATIONAL EXPERIENCES FOR STUDENTS FROM UNDER REPRESENTED GROUPS WHO ARE ATTENDING THE MINORITY SERVING INSTITUTIONS. NEXT SLIDE, PLEASE. SO THE PROPOSAL IS TO DEVELOP AN EQUIPMENT GRANT FOA TARGETED TO MINORITY SERVING INSTITUTIONS WITH LIMITED RESOURCES. THE FOA WOULD HELP PRO VIED INSATION TO HELP THEIR RESEARCH CAPACITY, NIGMS HAS AGREED TO SERVE AS LEAD IC TO SUPPORT OVERALL COURT NATION OF THE PROGRAM AND THE IDEA IS OTHER ICS AT OTHER CENTERS WOULD PARTICIPATE BY SIGNING ON TO FOAS AND FUNDING AWARDS ON THEIR OWN. NEXT SLIDE, PLEASE. A COUPLE OF OTHER CONSIDERATIONS AND I THINK RATIONALIZATIONS FOR WHY A SPECIFIC PROGRAM FOR EQUIPMENT GRANTS TO UNDERRESOURCE MINORITY SERVING INSTITUTIONS ARE WARRANTED WOULD BE THAT THE INSTRUMENTS MUST BE HOUSED AT THE ELIGIBLE MINORITY SERVING INSTITUTION SO THEY WOULD BE THE OWNERS AND OPERATORS OF IT. BUT LOCAL COLLABORATIONS WITH OTHER INSTITUTIONS WOULD NOT JUST BE ALLOWED BUT ENCOURAGED. SO THE MAJOR USERS COULD BE RESOURCED RESEARCHERS AT THE MINORITY SERVING INSTITUTION, OTHER THE SAME DEPARTMENT OR SEVERAL DEPARTMENTS OR DIVISIONS BUT ALSO FROM NEARBY OR REGIONAL INSTITUTIONS AND SO THAT REQUIREMENT OF THREE MAJOR USERS OF NIH GRANTS AT THE INSTITUTION WOULD BE EASIER TO MEET BECAUSE RESEARCHERS AT OTHER INSTITUTIONS COULD BE SOME OF THOSE MAJOR USERS BUT SHIFT OF THE BALANCE THAT THE CENTER OF GRAVITY IS SHIFTED FROM THE INSTITUTIONS IN THE NEIGHBORHOOD TO THE LOWER RESOURCED INSTITUTION BECAUSE THEY ARE THE ONES WITH THE EQUIPMENT AND THE BETTER RESOURCED INSTITUTIONS WOULD BE COMING TO THEM AND HAVING TO COLLABORATE FROM THAT ANGLE. AND THEN ADDITIONAL USERS IN THIS NEW VERSION PROGRAM WOULDN'T HAVE TO BE PRINCIPLE INVESTIGATORS, THEY COULD BE PEOPLE PARTICIPATING IN TRAINING OR RESEARCH EDUCATIONAL PROGRAMS, STUDENTS, POSTDOCS, ET CETERA, AND THEREFORE WE WOULD BE SPECIFICALLY RECOGNIZING IMPLEMENTATION WOULD BE NOT JUST FOR THE RESEARCH PART OF THE INSTITUTION BUT ALSO FOR THE TRAINING AND EDUCATION PART OF THE INSTITUTION. NEXT SLIDE, PLEASE. SO WITH THAT, ARE THERE ANY COMMENTS ON THIS PROPOSAL? LESLIE? >> OKAY, YEAH, WITH ANY BIG EQUIPMENT, THERE ARE OFTEN THE MAINTENANCE ASPECT, RIGHT, SERVICE CONTRACTS, SO IS THERE A MECHANISM WORKED INTO THAT BECAUSE I FEEL LIKE EVEN AT DAVIS WE HAVE TROUBLE WITH THE SERVICE CONTRACTS FOR OUR FANCY MARC SCOPES SO AT NSI, IT WOULD BE EVEN HARDER TO MAINTAIN THESE THINGS AFTER THEY GET THEM. >> YEAH, I THINK THAT IS SOMETHING WE WILL HAVE TO BE LOOKING AT. IT IS AN EXCELLENT POINT AS WE DEVELOP THE FO FOA AND COULD SERVICE CONTRACTS BE IMPLEMENTED AS PART OF THE FOA WOULD BE PART OF THAT. AND I THINK ANCILLARY PROGRAMS, WAYS TO FUND SERVICE, TECHNICIANS WITHIN THE INSTITUTION WOULD BE SOMETHING TO THINK OF AS WELL. WHEN I WAS AN UNDERGRADUATE, SOMEONE IN THE CHEMISTRY DEPARTMENT WAS THE GURU OF ALL THE ININS MULTIPLES INSTRUMENTS AND KNEW HOW TO SUPPORT THEM AND I WAS INCREDIBLY GRATEFUL THERE WAS THAT. AND THERE MAY BE COLLABORATION BETWEEN THE UNDER RESOURCED INSTITUTION AND MAJOR INSTITUTION TO PROVIDE ECONOMIES OF SCALE IN THOSE CAPACITIES TO CERTAINLY SOMETHING TO THINK ABOUT AS WE DEVELOP THE PROGRAM. DAVID? >> SO ADDRESSING THE PROBLEM OF FUNDING MAJOR USERS I THINK IS REALLY IMPORTANT AND I HYPOTHESIZE THAT MAY BE THE BIGGEST BARRIER TO HIS TANS TO APPLY FOR THE GRANT. SO YOU HAVE ON THE SLIDE THAT USERS COULD BE A EDUCATIONAL PROGRAM OR ENDEAVOR, COULD THE UNDER USER BE THE EDUCATIONAL MEMBER OR MEMBER FROM THE LAB? >> I THINK THAT IS A GOOD IDEA AND WOULD BE A UNIQUE ASPECT OF THIS PROGRAM IN PARTICULAR. >> I THINK THAT IS GREAT AND IF YOU ARE EXPLICIT ABOUT THAT THAT AN ONGOING TEACHER PROGRAM COULD BE A MAJOR USER -- >> I THINK THAT IS VERY IMPORTANT AND MAKE SURE THAT GETS SPECIFICALLY SPELLED OUT, A GREAT POINT. SQUIRE? >> YES, AS LONG AS WE ARE FACTORING, IT IS HARD TO SAY AND I GUESS MY QUESTION IS DID YOU SAY THAT YOU HAVE TO HAVE AT LEAST THREE PEOPLE WITHIN NIH GRANTS TO APPLY? >> THAT IS THE CURRENT PROGRAM AT ORIP. ONE OF THE ITEMS IN THE PROGRAMMING IS TO MODIFY AND HAVE DIFFERENT ONES. >> SO NOBODY WOULD HAVE TO HAVE A NIH GRANT? >> WE COULD -- >> I MEAN, I DON'T -- AT A RO1 INSTITUTION WHERE NOBODY HAS A NIH GRANT, RIGHT, I THINK THAT IS A POTENTIAL BARRIER. >> YEAH, I THINK YOU ARE ABSOLUTELY RIGHT. I AGREE. >> OKAY. >> AND I THINK WE WILL HAVE TO THINK ABOUT HOW TO BALANCE WHAT LESLIE SAID, MAKING SURE THERE ARE SOME RESOURCES TO SUPPORT THE INSTRUMENT AND MAINTAIN IT AND -- >> ABSOLUTELY, THAT IS A VERY GOOD POINT, YEAH. [OVERLAPPING SPEAKERS] YOU KNOW BECAUSE YOU DON'T WANT TO INVEST AND THEN CAN'T MAINTAIN IT. >> EXACTLY RIGHT OR NOBODY IS ACTUALLY GOING TO USE IT AND IT WILL JUST SIT THERE SO I THINK THOSE ARE IMPORTANT POINTS ABOUT IT, TO MAKE SURE THAT, YOU KNOW, CORRECT INFORMATION IS REQUESTED IN THE APPLICATION AND ASSESSED BY THE PANEL TO MAKE SURE THOSE THINGS ARE ALL MET. >> YEAH, IT IS A BIT OF A SLIPPERY SLOPE BECAUSE EDUCATORS, YOU DO IT FOR EDUCATION AND THAT WOULD BE A WIN FOR EVERYBODY BUT THERE IS NO MONEY THEN FOR THE STUDENTS THAT ARE BEING TRAINED TO ACTUALLY DO REAL RESEARCH PROJECTS. >> YEAH. >> SO ALL BECAUSE SORT OF ALMOST, YOU KNOW, ARTIFICIAL -- SO THEY KIND OF -- THIS IS HOW YOU WOULD USE THE MACHINE IF WE ACTUALLY COULD USE THIS TO DO AN ACTUAL BIOMEDICAL RESEARCH PROJECT. >> BUT THERE ARE OTHER SOURCES OF MONEY THESE PEOPLE HAVE. >> THAT IS WHAT I AM SAYING, SO IF THEY COULD JUSTIFY WHAT FUNDS AND PROJECTS WOULD BE ENHANCED, YEAH. >> YEAH AND ENGINE WE CAN CERTAINLY BROADEN THE NIH FUNDING AND I THINK THOSE ARE EXCELLENT POINTS AND WE NEED TO MAKE SURE WE GET THE RIGHT BALANCE IN WHAT WE'RE LOOKING FOR IN PUTTING IN THE FOA. PAMELA? >> YES, THANK YOU. ONE OF THE THINGS THAT -- SO A LOT OF THESE ADVANCES REALLY MAKE IT POSSIBLE SO THAT'S REALLY TO BE APPLAUDED. THE OTHER JUST SORT OF COMPARING SOME OF THE NSF MAJOR RESEARCH INSATION INS INSTRUMENTATION PROGRAMS THAT ARE POSSIBLE DON'T HAVE 25 PERCENT USAGE OF THE EQUIPMENT AND YET YOU COULD HAVE AS SQUIRE I WANTED INDICATED, YOU COULD HAVE A PIECE OF EQUIPMENT THAT HAS REALLY MAJOR IMPACT BUT IN SECTIONS OF MULTIPLE PROJECTS. AND THAT MODEL HAS BEEN IMMENSELY HELPFUL TO INCREASING THE CAPACITY OF SOME OF THE INSTITUTIONS OF THE NSIS. >> EXCELLENT AND I THINK AGAIN THAT IS WHY THIS NEW FOA IS WARRANTED SO THAT WE WOULD NOT HAVE TO HAVE THAT 25 PERCENT USAGE REQUIREMENT, ARE ABSOLUTELY RIGHT. LAURA? >> THERE IS OBVIOUSLY ENTHUSIASM FOR IT SO THAT IS COOL. I AM WONDERING IF THE USER JUSTIFICATION COULD BE A TEAM OF INVESTIGATORS THAT ARE REALLY CLEARLY ALIGNED WITH AN INSTITUTIONAL PRIORITY AREA BECAUSE THAT WAY THERE COULD BE OTHER INVESTMENT FROM AN INSTITUTIONAL PERSPECTIVE TO AMPLIFY YOUR INVESTMENT AND SPRING BOARD THAT POTENTIALLY AND THEN MIGHT ALSO COLLECTIVELY STIMULATE A REASONABLE AMOUNT OF FUNDING FROM OTHER FOUNDATIONS OR RESOURCES OUTSIDE OF NIH OF THAT CRITICAL MASS. MAKE ANY SENSE? >> MAKES A LOT OF SENSE. YOU COULD THINK OF PROJECTS TO DO SURVEILLANCE FOR VIRUSES AND JUSTIFYING SEQUENCING, YOU KNOW, EQUIPMENT, ET CETERA. YEAH. AND I THINK IT ALSO BRINGS UP THE QUESTION OF, YOU KNOW, WHO ELSE COULD BE USING THAT FACILITY? COULD IT BE STATE LABS THAT HAVE A NEED FOR SOME KIND, COULD IT BE INDUSTRY, LOCAL SMALL BUSINESSES, I THINK WE NEED TO EXPLORE SOME OF THESE POTENTIALS TO SEE WHO ELSE COULD HELP SUPPORT IT AND USE IT. GREAT POINT. OKAY, THAT WAS A GREAT DISCUSSION. ERICA? DO YOUR THING. >> OKAY, I MOVE WE APPROVE THIS CONCEPT FOR FURTHER DEVELOPMENT AS AN FOA. ARE ANY OPPOSED? UNANIMOUSLY APPROVED, THANK YOU. >> AND THOSE WERE EXTREMELY HELPFUL COMMENTS WE HAVE CAPTURED AND WILL DEFINITELY INCORPORATE AS WE MOVE FORWARD WITH THE -- SO THANK YOU ALL VERY MUCH. I THINK AT THIS POINT WE WILL TAKE A SHORT BREAK SO WHY DON'T WE COME BACK AT 11: 15 AND WE WILL CONTINUE WITH SOME MORE CONS ZEST -- CONCEPT CLEARANCES SO THANK YOU ALL AND WE'LL SEE YOU AT 11: 15. WELCOME BACK. WE ARE NOW GOING TO KEEP GOING WITH THE CONCEPT CLEARANCES AND WE ARE GOING TO HEAR FROM DOROTHY BECKETT WHO IS GOING TO TALK TO US ABOUT THE BTDD PROGRAM WHICH IS NOT A NEW PROGRAM BUT THERE ARE SOME CHANGES WE'RE PROPOSING AND WE MOSTLYT TO JUST REMIND PEOPLE OF THE PROGRAM. DOROTHY? >> OKAY, SO, MY NAME'S DOROTHY BECKETT AND I'M THE DIRECTOR OF THE DCBG HERE AT NIGMS AND TODAY I WILL TALK ABOUT THE REISSUANCE OF FUNDING ANNOUNCEMENT FOR THE BTDD PROGRAM, SO THE BTDD PROGRAM IS THE BIOMEDICAL TECHNOLOGY AND DEVELOPMENT AND DISSEMINATION. I WILL TELL YOU ABOUT THE PURPOSE AND HOW THIS PROGRAM WORKS AND THE CHANGES WE WILL MAKE IN THE FOA, OR WE'RE PLANNING TO. NEXT SLIDE. SO WHAT'S THE PURPOSE OF THESE CENTERS? AS PART OF OUR TECHNOLOGY DEVELOPMENT PIPELINE AND THE IDEA IS TO SUPPORT DEVELOPMENT OF LATE STAGE TECHNOLOGIES THAT HAVE BROAD UTILITY FOR BIOMEDICAL RESEARCH, ONCE THEIR FEASIBILITY HAS BEEN ESTABLISHED. AND EQUALLY IMPORTANT THE PURPOSE IS TO DISSEMINATE THESE TECHNOLOGIES TO THE WIDER BIOMEDICAL RESEARCH COMMUNITY SO THAT THEY COULD USE THEM. SO THE IDEA IS TO ESTABLISH A MEANS OF SUPPORTING CENTERS THAT ARE AT THE MEETING EDGE OF THEIR FIELDS WITH RESPECT TO BOTH TECHNOLOGY DEVELOPMENT AND ENGAGEMENT WITH RELEVANT RESEARCH COMMUNITIES AND FINALLY, IS TO DISSEMINATE THESE TECHNOLOGIES IN A SUSTAINABLE MANNER AND PROVIDE USER TRAINING, SO, ULTIMATELY, THE IDEA IS THAT THESE CENTERS WILL PUT THEMSELVES OUT OF BUSINESS BY MAKING--BY BRINGING THE TECHNOLOGY TO A STAGE AT WHICH IT CAN BE BROADLY UTILIZED BUT EQUALLY IMPORTANT BY PROVIDING USER TRAINING IN THE CORRECT USE OF THE TECHNOLOGY. NEXT SLIDE, PLEASE. SO HOW DO THESE CENTERS WORK? THEY ARE--IT'S INTEGRATION OF 3 COMPONENTS, BUT IT IS A SINGLE RESEARCH EFFORT THAT INCORPORATES TECHNOLOGY DEVELOPMENT, BY O MEDICAL RESEARCH PROJECTS AND COMMUNITY ENGAGEMENT. SO FIRST I'M GOING TO DISCUSS HOW THE TECHNOLOGY DEVELOPMENT IS INTEGRATED WITH THE RESEARCH PROJECTS. NEXT SLIDE, PLEASE. SO THE IDEA IS THAT THROUGH THE COUPLING OF THE TECHNOLOGY DEVELOPMENT PROJECTS WITH DRIVING BIOMEDICAL RESEARCH PROJECTS, YOU REFINE AND OPTIMIZE THE TECHNOLOGY. AND ON THE TECHNOLOGY DEVELOPMENT PROJECT SIDE, THE TDDs, THIS MUST--THEY SHOULD BE LATE STAGE TECHNOLOGIES THAT ARE AT THE STAGE OF OPTIMIZATION. THE FOCUS CAN BE ON A SINGLE SECNOLOGY OR AN INTEGRATED TECHNICAL APPROACH. AND THE CENTERS MAY UTILIZE SHORT-TERM TECHNOLOGY PARTNERSHIPS TO ACCELERATE THE TECHNOLOGY DEVELOPMENT. AND ON THE DRIVING BIOMEDICAL PROJECT SIDE, THESE ARE TEST BEDS, SO BASICALLY, THE TECHNOLOGY IS CHALLENGED BY THE DRIVING BIOMEDICAL PROJECTS. THEY SHOULD ADDRESS A RANGE OF BIOMEDICAL RESEARCH QUESTIONS, OBVIOUSLY RELEVANT TO THE TECHNOLOGY AND THE BTDD SHOULD HAVE A GEOGRAPHICAL DISTRIBUTION AND THESE PROJECTS SHOULD BE INDEPENDENTLY FUNDED SO AGAIN, THROUGH THE ITERATIVE INTERACTION, THE INTERACTION BETWEEN THE TDPs AND THE DDPs, YOU OPTIMIZE THE TECHNOLOGY. NEXT SLIDE, PLEASE. AND A VERY LARGE COMPONENT OF THESE CENTERS IS COMMUNITY ENGAGEMENT BECAUSE AGAIN, POINT IS TO BROADLY DISSEMINATE THIS TECHNOLOGY AND YOU'RE GOING TO DISSEMINATE IT THROUGH TRAINING, THROUGH MECHANISMS OF DISSEMINATION AND ALSO THERE IS AN OPTIONAL COMPONENT WHICH IS THAT YOU CAN ENGAGE THE BROADER COMMUNITY THROUGH COLLABORATIONS AND SERVICE PROJECTS WITH THE MORE MATURE COMPONENTS OF THE TECHNOLOGY. SO IN THE TRAINING, THE IDEA IS TO ENHANCE THE USER UNDERSTANDING OF THE TECHNOLOGY, IT SHOULD BE GEARED TOWARD BOTH EXPERTS AND NONEXPERTS AND THE IDEA OF COURSE IS TO CREATE A LARGE USER COMMUNITY OF NONSPECIALISTS AND RESEARCHERS. DISSEMINATION CAN TAKE MANY FORMS. THESE CENTERS CAN DIRECTLY TRANSFER THEIR TECHNOLOGIES TO OTHER LABORATORIES. THEY SHOULD PUBLICIZE THE TECHNOLOGY THROUGH USER FRIENDLY WEBSITES AND OTHER MECHANISMS AND THEY CAN HAVE PARTNERSHIPS OR THEY CAN FILE PATENTS, THEY CAN ALSO LICENSE THE TECHNOLOGY TO INDUSTRIAL PARTNERS. NEXT SLIDE. SO WHAT ARE THEIR CHANGES THAT WE'RE PROPOSING IN THE PROGRAM. THE PROGRAM AS YOU SAW, THE ORIGINAL ANNOUNCEMENT WAS RELEASED IN 2020. AND WHAT WE WOULD LIKE TO DO IN THE NEXT RELEASE IS TO CLARIFY THE MEANING OF OR THE INTENT OF LATE STAGE TECHNOLOGIES, YOU KNOW WHAT'S THE DIFFERENCE BETWEEN EARLY AND LATE STAGE. ADVERTISE THE BREDTH OF THE TECHNOLOGY AREAS THAT ARE SUPPORTED BY THE NIGMS TECHNOLOGY DEVELOPMENT PROGRAMS, IN ORDER TO--THE SECOND POINT IS IN ORDINANCE NUMBER TORE EMPHASIZE THE LATE STAGE NATURE OF THE TECHNOLOGY, WE WANT TO CHANGE THE NAME OF THE PROGRAM FROM BTDD TO BTOD WHICH IS BIOMEDICAL TECHNOLOGY OPTIMIZATION AND DISSEMINATION AND LIKEWISE CHANGE THE TDPs TO TECHNOLOGY OPTIMIZATION PROJECTS OR TOPs. AND FINALLY WE WOULD LIKE TO SIMPLIFY THE REVIEW PROCESS AS MUCH AS POSSIBLE. NEXT SLIDE. AND I'D LIKE TO THANK YOU FOR YOUR ATTENTION. IF HAVE YOU ANY COMMENTS OR QUESTIONS, PLEASE RAISE YOUR HAND. >> THANK YOU DOROTHY. QUESTIONS OR COMMENTS? >> NO QUESTIONS OR COMMENTS, THEN ERICA IT'S IN YOUR HANDS. >> OKAY, I MOVE THAT WE MAKE A MOTION TO MOVE THESE, ANY OPPOSE? >> MOTION IS UNANIMOUSLY APPROVED. THANK YOU MUCH. >> THANK YOU VERY MUCH DOROTHY. NEXT ALEXANDRA AINSZTEIN IS GOING TO TALK TO ABOUT THE TEAM SCIENCE COLLABORATIVE GRANT. >> GOOD MORNING EVERYONE, THIS IS THE REISSUANCE OF P A R2103, THE NIGMS COLLABORATIVE PROGRAM GRANT FOR MULTIDISCIPLINARY TEAM. I AM ALEXANDRA AINSZTEIN, AND I'M THE PROGRAM DIRECTOR FOR THIS PROGRAM. SO JUST A BIT OF BACKGROUND FIRST. WE ARE NOT INTENDING ANY MAJOR CHANGES TO THIS PROGRAM BUT WE'RE USING THIS OPPORTUNITY TO REMIND THE COMMUNITY OF THIS PROGRAM AND THE KEY FEATURES OF IT. THIS PROGRAM WAS FIRST STARTED IN 2017 AND THIS IS THE SECOND REISSUANCE, THIS PROGRAM COVERS ALL THE RESEARCH WITHIN THE NIGMS MISSION AND A LINK TO THE COMPLETE LIST OF AWARDED GRANTS AND RESOURCES INCLUDING WEBINARS AND FAQs CAN BE FOUNDOT NIGMS WEBSITE, AT THIS LINK. NEXT SLIDE, PLEASE. THIS PROGRAM IS DESIGNED TO SUPPORT AMBITIOUS AND CHALLENGING PROJECTS THAT WILL SOLVE SIGNIFICANT BIOMEDICAL PROBLEMS THAT CANNOT BE ACCOMPLISHED THROUGH INDIVIDUAL AWARDS LIKE RO1s. MULTIDISCIPLINARY TEAM IS KEY TO THIS PROGRAM WITH TEAMS COMPOSED OF 3 TO 6 INVESTIGATORS WITH SHARED SCIENTIFIC LEADERSHIP AND MANAGEMENT RESPONSIBILITIES, CONSIDERABLE TEAM INTERACTIONS ARE REALLY KEY A SINGLE WELL IMPOSSIBLE TO BUILD GREATED SET OF AIMS AND A BUDGET SHOULD BE PRESENTED. THERE ARE NO SUBPROJECTS PERMITTED. THERE SHOULD BE CO COLLABORATIONS FUNDED. THERE IS AN OPTION TO ADD NEW ESI TEAM MEMBERS IN FUTURE YEARS AS AN OPPORTUNITY TO EXPAND THEIR INITIAL GOALS OF THE GRANT AND THE EXPERTISE OF THE TEAM. NEXT SLIDE, PLEASE. SO JUST A FEW FEATURES OF AWARDED APPLICATIONS. EACH PI SHOULD BE COMMITTED TO TEAM SCIENCE AND BE WILLING TO DEVOTE A MAJOR PART OF THEIR RESEARCH EFFORT TO THIS TEAM PROJECT. TEAM SCIENCE APPROACH MUST BE ESSENTIAL FOR ACHIEVING THE GOALS IN THE APPLICATION. AIMS AND GOALS MUST BE WITHIN THE NIGMS MISSION INCLUDING GENERALIZABLE, FUNDAMENTAL BASIC RESEARCH AND A LIMITED NUMBER OF CLINICAL AREAS THAT AFFECT MULTIPLE ORGAN SYSTEMS. AND AGAIN, THAT'S AVAILABLE, OUR MISSION IS AVAILABLE THROUGH THE FIRST LINK THAT I SHOWED YOU ON OUR WEBSITE. A COHESIVE TEAM WITH AN INTEGRATIVE APPROACH FOR EACH BIOLOGICAL QUESTION POSED AND AN EFFECTIVE TEAM MANAGEMENT STRUCTURE TO ACHIEVE THESE PROGRAM GOALS. NEXT SLIDE, PLEASE. AND THIS IS THE ESTIMATED TIMELINE OF THE FOA, WILL EXPIRE IN JANUARY OF 2023. THE CONCEPT CLEARANCE IS BEING DONE TODAY, THE FIRST RECEIVED IN MAY OF 2023 WITH THE FIRST AWARDS BEING DONE IN APRIL OF 2024. ARE THERE ANY QUESTIONS? >> QUESTIONS OR COMMENTS FOR ALEXANDRA? >> I THINK 1 TECHNOLOGY TRANSFER I WILL JUST NOTE IS THAT WE FEEL LIKE WE FUNDED A NUMBER OF THINGS THAT WE DO MEET THAT ALEXANDRA LAID OUT BUT WE ALSO FEEL THAT WE'VE SEEN A LOT OF APPLICATIONS THAT DON'T MEET THOSE REQUIREMENTS AND SO, PART OF THE GOAL HERE WAS TO TRY TO HELP GET OUT TO THE COMMUNITY AGAIN, WHAT IT IS WE ARE LOOKING FOR AND WHAT IT IS WE'RE NOT LOOKING FOR SO I THINK SHE DID A NICE JOB LAYING THAT OUT. ANY OTHER COMMENTS OR QUESTIONS? OKAY. ERICA? >> I MOVE THAT WE APPROVE THIS CONCEPT FOR FURTHER DEVELOPMENT AS AN FOA, ARE THERE ANY OPPOSED? OKAY, THE MOTION IS UNANIMOUSLY APPROVED. >> GREAT. THANK YOU VERY MUCH ALEXANDRA. NEXT WE ARE GOING TO HEAR FROM MING WHO IS GOING TO TALK ABOUT A COUPLE OF CONCEPT CLEARANCES, 1 FOR THE NARCH PROGRAM ITSELF AND THE FIRST OF WHAT WILL BE SEVERAL ANCILLARY PROGRAMS RELATED TO NARCH THAT CAME FROM THE TRIBAL EVALUATION AND CONSULTATION. MING? >> THANK YOU, JOHN. HELLO EVERYONE. AS JOHN JUST MENTIONED, I AM GOING TO--FOR HEALTH OR NARCH, FOA, THE SECOND IS ISSUANCE OF THE NEW FOA TO SUPPORT PLANNING GRANTS THAT HELP DEVELOP NARCH APPLICATIONS. SO YOU MAY--NEXT SLIDE, PLEASE. YOU MAY RECALL THAT NIGMS CONDUCTED AN EVALUATION OF THE NARCH PROGRAM FOR THE PURPOSE OF STRENGTHENING THE PROGRAM. THE EVALUATIONS STARTED WITH A COLLECTION OF A COMPREHENSIVE SET OF DATA ON NARCH PROGRAM PERFORMANCE AND OUTCOMES. THEN, A COUNCIL WORKING GROUP LED BY DARREN AKENS AND THE [INDISCERNIBLE] ANALYZED THE DATA AND DEVELOPED RECOMMENDATIONS. THEN THEY PRESENTED THEIR FINDINGS AND A RECOMMENDATIONS TO THE [INDISCERNIBLE] EDGE TRIBAL ADVISORY COMMITTEES FOR INPUT. AFTER THAT NIGMS DIRECTOR JOHN LORSCH HELD A FORMAL CONSULTATION WITH TRIBAL LEADERS. FOLLOWING THE CONSULTATION, THE TRIBAL LEADERS PROVIDED THEIR FORNLAL FEEDBACK IN WRITING WHICH HELPED GM DEVELOP IMPLEMENTATION PLAN THAT WAS PRESENTED TO COUNCIL BY JOHN LAST SEPTEMBER AND THE PLAN HAS BEEN POSTED ON GM WEBSITE WHICH IS AVAILABLE FOR EVERYBODY. NEXT SLIDE, PLEASE. SO HERE IS A SUMMARY OF THE TRIBAL LEADERS FEEDBACK. WE RECOGNIZE THE IMPORTANCE OF NARCH AS THE FEDERAL GOVERNMENT'S PREMIER PROGRAM THAT IT CAN HOUSE RESEARCH FOR AMERICAN INDIANS AND ALASKA NATIVES AND IT ASKED US TO EXPAND THE PROGRAM IN SEVERAL IMPORTANT ASPECTS. FIRST, IS TO INSURE THAT RESEARCH AND THE CAPACITY BUILDING SUPPORTED BY THE PROGRAM ARE PRIMARILY CONDUCTED BY TRIBAL NATIONS OR ORGANIZATIONS INSTEAD OF THEIR ACADEMIC COLLABORATORS. THEY ALSO WANT TO SEE AN EXPANSION IN APPLICANT AND GRANTEE POOLS. REMIND YOU THERE ARE 574 ELIGIBLE TRIBAL NATIONS IN THE COUNTRY, ALSO THAT THIS EXPANSION IS TO BE ACCOMPLISHED BY REDUCING THE COMPLEXITY OF APPLICATIONS AND EFFORTS TO DEVELOP NEW APPLICANTS AND OF COURSE, THEY EXPECT ADDITIONAL FUNDING TO SUPPORT THE BIGGER GRANTEE POOL. THEY ALSO WANT TO SEE LARGE PROGRAM TO SUPPORT A/AN TRAINEES STARTING HIGH SCHOOL AND STRENGTHEN ITS SUPPORT OF LEVELS OF COLLEGE AND ABOVE. AND IMPORTANTLY THEY EXPECT THE CULTURALLY APPROPRIATE REVIEWED GUIDELINES LISTED AT THE BOTTOM OF THE SLIDES THAT WAS DEVELOPED BY NIH AFTER THEY ARE FULLY IMPLEMENTED IN FUTURE AND LARGE APPLICATION REVIEW. AND FINALLY, THEY WANT TO HAVE TRIBAL CONCELTATION AS A REGULAR ACTIVITY OF NARCH PROGRAM. NEXT SLIDE, PLEASE. SO IN RESPONSE TO THE TRIBAL LEADERS REBUT, GM PLANS TO STRENGTHEN THE NARCH PROGRAM WITH A COLLECTION OF NEW FUNDING INITIATIVES THAT ADDRESS VARIOUS NEED. AS PART OF THE PLAN, I WILL DISCUSS THE TOP 2 ON THE LIST, NEXT SLIDE PLEASE. SO FIRST THE NARCH PROGRAM. THE OBJECTIVE OF THE PROGRAM HAVE BEEN AND WILL REMAIN TO BE TO SUPPORT HEALTH RESEARCH PRIORITIZED BY AI/AN COMMUNITIES. TO PROMOTE HEALTH EQUITY FOR AI/AN POPULATIONS, TO BUILD CAPACITY AND INFRASTRUCTURE WITHIN TRIBAL ORGANIZATIONS TO ENGAGE IN HEALTH RESEARCH AND TO DEVELOP A CADRE OF SCIENTISTS AND RESEARCH RESEARCH PROFESSIONALS COMMITTED TO AI/AN HEALTH RESEARCH. NEXT SLIDE, PLEASE. OBJECTIVES OF THE PROGRAM REMAIN THE SAME. WE WILL CONSIDER A NUMBER OF PROGRAMMATIC CHANGES IN THE NEW FOA FOR IMPROVEMENT EXPECTED BY THE TRIBAL LEADERS. ONE IS TO ENCOURAGE AI/AN ORGANIZATIONS TO LEAD AND CONDUCT A NARCH SUPPORTED ACTIVITIES BY INCREASING THE PORTION OF AWARD BUDGET TO BE SPENT FOR AI/AN ORGANIZATIONS. CURRENTLY THAT NUMBER STANDS AT 30% AND WE'RE TO CONSIDER INCREASE THAT. ANOTHER MAJOR CHANGE IS TO PROVIDE CLEAR INSTRUCTION TO BOTH APPLICANTS AND THE REVIEWERS THAT ENCOURAGE RESEARCH APPROACHES THAT ARE CULTURALLY APPROPRIATE FOR AI/AN COMMUNITIES. WE WILL ALSO CONSIDER EXPANDING EVALUATION CRITERIA TO INCLUDE NONTRADITIONAL ACADEMIC INDICATORS SUCH AS APPLICATIONS, IMPACT ON TRIBAL HEALTH AND HEALTH POLICY AND APPLICANT AND GRANTEES COMMUNITY SERVICE AND TRIBAL LEADERSHIP ROLE AS FOR SUCCESSFUL MEASURES. WE WILL SUPPORT K-12 STEM EDUCATION ACTIVITIES IN ADDITION TO SUPPORT TO COLLEGE LEVEL AND ABOVE TRAINING. NEXT SLIDE, PLEASE. WE WILL MAKE AN EFFORT TO INCLUDE CULTURALLY APPROPRIATE REVIEW LANGUAGE IN REVIEW CRITERIA OF THE NEW FOA AND TO WORK WITH OUR COLLEAGUES IN CSR, TO MAKE SURE THAT THEY--THOSE NEW GUIDELINES ARE ADAPTED OR IMPLEMENTED. FURTHER MORE, WE WILL MAKE SURE THAT RESEARCH, CAPACITY BUILDING AND CAREER ENHANCEMENT, THOSE ARE 3 PILLARS OF THE NARCH PROGRAM, THE EXPERTISE IN ALL 3 AREAS, ALL REPRESENTED IN REVIEW [INDISCERNIBLE]. FURTHER MORE, WE WILL MAKE THE FOA ACTIVITY EVERY YEAR IN OTHER WORDS TO ACCEPT APPLICATIONS, EVERY YEAR INSTEAD OF THE CURRENT 2 YEARS ON, 2 YEARS OFF ARRANGEMENT AND EXTEND AWARD FROM 4-5 YEARS. IT WILL SIMPLIFY APPLICATION WITH CLEAR INSTRUCTIONS AND STREAMLINE REQUIREMENT FOR APPLICATIONS AND FINALLY, WE WILL ALSO STREAMLINE ADMINISTRATIVE PROCESS TO SPEED UP THE WORK ISSUING TO THE GRANTEE INSTITUTIONS. WITH THE NEW FOA WILL MAKE A SERIES OUTREACH EFFORT TO MAKE SURE THAT THE COMMUNITY IS WELL INFORMED ABOUT ALL THE CHANGES IN THE NEW FOA FOR THEIR OPERATION FOR THE NEXT APPLICATION. NEXT SLIDE, PLEASE. SO THAT'S FOR NARCH. I WILL MOVE ON TO THE SECOND CONCEPT THAT IS FOR THE NEW INITIATIVE TO FUND PLANNING GRANTS FOR NARCH APPLICATIONS FOR TRIBEs OR TRIBAL COMMUNITY ORGANIZATIONS THAT DON'T HAVE NARCH AWARD CURRENTLY. NEXT SLIDE, PLEASE. SO THE GOAL FOR THIS NEW INITIATIVE IS TO INCREASE MEMBER OF THIS NEW NARCH APPLICATIONS SO THE TARGET AUDIENCE APPLICANT WILL BE THE FEDERALLY RECOGNIZED TRIBES AND TRIBAL ORGANIZATIONS THAT DON'T HOLD ACTIVE NARCH AWARD CURRENTLY. THE INITIATIVE OR NEW AWARD MAY SUPPORT ACTIVITIES INCLUDE EFFORT TO DEFINE RESEARCH QUESTIONS AND DEVELOP PLANS TO ANSWER THEM, NEEDS ASSESSMENT FOR CAPACITY-BUILDING AND CAREER ENHANCEMENT BY THE NARCH PROGRAM, EFFORT TO STRENGTHEN OFFICE OF TO SPONSOR PROGRAMS TO SUPPORT APPLICATION SUBMISSION AND GRANTS MANAGEMENT AND EFFORT TO SECURE EXTERNAL SUPPORT FOR DEVELOPING NARCH APPLICATIONS INCLUDING IDENTIFYING CONSULTING CONTRACTORS AND COLLABORATORS AS WELL AS TRAVEL AND MEETINGS. AND WITH THAT, I WILL BE HAPPY TO ANSWER YOUR QUESTIONS. >> THANKS, MING. QUESTIONS, COMMENTS? TERRY? >> HI, MING, IF I REMEMBER CORRECTLY WHEN WE HEARD THE ORIGINAL PRESENTATION, THERE WAS ALSO AN ISSUE THAT WHEN AN ORGANIZATION RECEIVED THE AWARD THEY ALMOST NEVER WENT IN FOR RENEWAL, IF I REMEMBER THAT CORRECTLY, IF SOMEONE HAS A LAPSED FORMER AWARD, THEY WOULD BE ELIGIBLE TO STILL GET THE PLANNING GRANT BECAUSE I HAPPEN TO BE A BIG FAN OF PLANNING GRANTS. I THINK THEY ARE REALLY INSPIRATIONAL IN GETTING PEOPLE TOGETHER THAT MIGHT NOT BE WILLING TO PUT IN THE EFFORT ON A BIG GRANT. >> YES, YOU ARE CORRECT. THE 1S WHO HAD 1 WHO IS CURRENTLY GAP OR THE 1S WITH APPLIED ACTUALLY NEVER SUCCEEDED, THEY ARE ALL ELIGIBLE FOR THE PLANNING GRANT. >> THANK YOU. >> DARRIN? >> YEAH, AS A CO-CHAIR OF THIS COMMITTEE WHICH WAS A VERY LONG PROCESS, I JUST WANT TO THANK MING, YOU AND JOHN AND THE WHOLE STAFF, I MEAN, IT SEEMS LIKE EVERYTHING WE DISCUSSED OVER A VERY LONG TOWARD HAS BEEN I THINK INCORPORATED IN A VERY SUCCINCT VERY WELL WAY SO I WANT TO GIVE YOU KUDOS, THIS IS EXACTLY WHAT I WAS HOPING TO SEE. SO, I AM BEHIND IT. >> AND I WOULD SAY DARIN, WE'RE VERY GRATEFUL TO THE GREAT WORK AND RECOMMENDATIONS BY THE WORKING GROUP LED BY YOU AND PAM. >> ABSOLUTELY, SPEAKING OF PAM, PAM? >> THANKS. YES, DITTO TO DARIN'S COMMENTS. ADDITIONALLY, IT JUST FELT LIKE THERE WERE A LOT OF LESSONS, A LOT OF LESSONS LEARNED IN TERMS OF THE--HOW WE THINK ABOUT PARTNERSHIPS, AND THE CLEAR NOTION ABOUT HOW TO BUILD CAPACITY CERTAINLY THERE'S NUANCES IN TERMS OF DIFFERENT KINDS OF COMMUNITIES THAT WE'RE SEEKING TO PROVIDE HEALTH EQUITY ISSUES AND RESEARCH, BUT I WAS THINKING ABOUT SOME OF THE OTHER PROGRAMS THAT WE WILL BE DISCUSSING LATER HOW TO INSURE THAT THE COMMUNITIES THAT WE'RE SERVING ACTUALLY HAVE THE ABILITY TO BUILD THAT RESEARCH CAPACITY AND HAVING THESE PLANNING GRANTS, I THINK WITH THE EXTENSIVE ROLE OF OUTREACH AS WELL IS GOING TO BE REALLY CRITICAL. SO I REALLY APPLAUD THE EFFORTS OF NIGMS ON THIS. THANK YOU. >> THAT'S A GREAT COMMENT, PAM. I STATED THAT WE'RE GOING TO DO A SERIES OUTREACH TO INFORM THE COMMUNITY ABOUT THE CHANGES FOR THE NARCH PROGRAM. OBVIOUSLY WE'RE GOING TO DO THE SAME FOR THE PLANNING GRANTS TO INSURE THE LARGE NUMBER OF ELIGIBLE TRIBES AND ORGANIZATIONS WHERE AND WELL INFORMED ABOUT THIS NEW OPPORTUNITY. ? GREAT, ANY ADDITIONAL COMMENTS OR QUESTIONS? OKAY, DON'T HEAR ANY. ERICA? >> OKAY, I MOVE THAT WE,A PROVE THESE CONCEPTS FOR FURTHER DEVELOPMENT AS FOAs, IS ANYONE OPPOSED? >> THANK YOU, THE MOTION IS UNANIMOUSLY APPROVED. >> THANK YOU. GREAT, SO I THINK THAT ACTUALLY CONCLUDES THE BUSINESS OF THE OPEN SESSION. ARE THERE ANY OTHER TOPICS THAT ANYONE WOULD LIKE TO BRING UP OR FOR A FUTURE CONSIDERATION OR QUESTIONS THEY HAVE NOW? >> SO JOHN THIS IS SCWIER, YOU KNOW, I THINK AT THE LAST COUNCIL MEETING, WE GOT ANI MAIL ABOUT TOPICS FOR DISCUSSION AND I THINK IT WAS PETER ESPEN SHADE, SORRY PETE FER IT WASN'T YOU, BROUGHT UP THIS ISSUE OF YOU KNOW THE GRANTS JUST NOT GOING AS FAR AS THEY USED TO GO IN TERMS OF AMOUNTS, RIGHT? ESPECIALLY NOW THAT WE'RE EXPERIENCING THIS INFLATION THING, OUR GRANTS ARE EASILY 20% LESS THAN WHAT THEY WERE, YOU KNOW A YEAR AGO, BUT I GUESS THE QUESTION I HAVE IS I DON'T THINK WE EVER HAD THAT DISCUSSION ABOUT THAT TOPIC LAST TIME? >> PART OF IT WAS TO SHOW THE DATA FROM THE RENEWALS THAT BUDGET INCREASES DO HAPPEN, I THINK-- >> YEAH, I SAW THAT. >> THERE HAVE BEEN STATEMENTS IN THE COMMUNITY THAT THERE HAS BEEN NOTHING TO KEEP UP WITH INFLATION AND BUDGET VS BEEN FLAT, OVER THE LAST 20 YEARS AND THAT'S JUST NOT TRUE WHEN YOU LOOK AT THE DATA. BUDGETS HAVE ACTUALLY INCREED MORE OR LESS KEPT UP WITH INFLATION AT SOME LEVEL UNTIL RECENTLY, RIGHT WHEN INFLATION'S GOTTEN BIGGER. BUT WE COULD HAVE A MORE INDEPTH DISCUSSION ABOUT--WITH,A DITIONAL DAT DATA. >> RIGHT, BUT IT WASN'T ALWAYS JUST INFLATION, IT WAS YOU KNOW NEW PAY LEVELS FOR EXAMPLE THAT WERE INSTITUTED BY NIH FOR POST DOCKERS AND THINGS LIKE THAT, IT SEEMED LIKE WE HAD TALKED ABOUT, YOU KNOW THE AMOUNT THAT PEOPLE TYPICALLY GET FOR AN RO1 FOR EXAMPLE, IT USED TO BE SOMETHING LIKE 192 OR SOMETHING LIKE THAT AND IT HAD BEEN THE SAME FOR QUITE SOMETIME IF I CAN REMEMBER AND IT HASN'T KEPT UP WITH THE RECENT COSTS, NOT JUST INFLATION. >> SO WE COULD CERTAINLY HAVE A MORE INDEPTH DISCUSSION WITH MORE DATA, WOULD PROBABLY BE THE BEST THING TO DO. >> SO TELL ME THIS, SO TYPICALLY WHEN YOU ASK FOR 250, THE STANDARD AMOUNT THAT 1 USED TO GET WAS LIKE SOMEWHERE AROUND 192, I CAN'T REMEMBER EXACTLY. HAS THAT CHANGED? >> YES, THAT HAS GONE UP,. >> OKAY, ALL RIGHT. >> IN THE LOW 200S NOW. >> OH, OKAY. ALL RIGHT. >> BUT YOU KNOW, YOU ARE CORRECT THAT OTHER COSTS DO INCREASE. YOU CAN LOOK AT THE OTHER SIDE OF THIS, OF COURSE, YOU CAN SEE WHERE IT'S GOING. >> WITH A LIMITED POOL OF MONEY,. >> RIGHT, RIGHT, RIGHT. I UNDERSTAND. >> PETER? >> YEAH, THANKS JOHN AND THANKS THANKS SCWIER FOR BRINGING THAT UP, I THINK IT WOULD BE INTERESTING TO HAVE A DISCUSSION OF LOOKING OVER THE 20 YEAR TIMELINE FOR THAT FUNDING, IT'S NOT NECESSARILY NIGMS, IT'S AN NIH WIDE ISSUE, SO WHEN I BRING IT UP I'M NOT CALLING OUT NIGMS SPECIFICALLY ON THAT. BUT 1 THING I DO IS I WORK CLOSELY WITH OUR STUDENTSA THE HOPKINS SCHOOL OF MEDICINE AND I CAN SAY THIS, WHETHER IT'S YOUR STAFF, POST DOCS, YOUR STUDENTS THAT INFLATION'S VERY REAL FOR THESE INDIVIDUALS AND JUST WANT TO PUT IT ON GM'S RADAR THAT THESE COSTS ARE GOING TO GET PASSED THROUGH, SO TYPE ENDS FOR ALL GRADUATE STUDENTS ACROSS THE COUNTRY WILL BE INCREASING, GRANTS PAY FOR THOSE IN LARGE PART. SO THAT MEANS THERE'S GOING TO BE FURTHER PRESSURES ON THE BUDGETS OF YOU KNOW EVERY NIH GRANT, SAME LIKELY HAPPEN TO POST DOC GRANTS SO I JUST WANT TO MAKE SURE THAT YOU'RE ACTIVELY THINK BEING HOW, YOU KNOW HOW TO ADDRESS THAT NEED, SINCE THOSE PERSONNEL COSTS ARE PROBABLY THE LARGEST PART OF THE GRANTS THAN EQUIP AND SUPPLIES WOULD BE DROPPING. >> ABSOLUTELY MPLET UNDERSTOOD. WE CAN SEE IF WE CAN DEVELOP SOME ADDITION DATA TO HELP GUIDE A CONVERSATION IN THE FUTURE. TERRY? >> I'M JUST GOING TO FOLLOW UP ON YOUR COMMENT ABOUT GRADUATE STUDENTS IN PARTICULAR. AS WE'RE SEEING INCREASING UNIONIZATION OF GRADUATE STUDENTS, IT IS DEFINITELY AFFECTING THE COST, SO ANYTHING THAT--WHETHER IT'S WORKING WITH THE COUNCIL ON GRADUATE SCHOOLS OR MONITORING WHAT THAT LOOKS LIKE BECAUSE IT'S MORE THAN JUST INFLATION, IT'S ALSO INCREASING MUCH LARGER REQUESTS FOR HEALTH INSURANCE AND THINGS LIKE THAT, THAT ARE PUSHING SOME OF THE COSTS WHICH WOULD ALSO IMPACT TRAINING GRANTS, AND FELLOWSHIPS, ET CETERA, IT'S SOMETHING TO KEEP AN EYE ON BEFORE BEFORE IT PERCOLATES UP AGAIN. >> THANK YOU. >> VERA SO IN THE UNIVERSITY OF PENNSYLVANIA 1 OF MY GRADUATE STUDENTS, SHE'S BASICALLY A PRESIDENT OF THE STUDENT ASSOCIATION AND WHAT I LEARNED RECENTLY IS THE STUDENTS ACTUALLY THE UNIVERSITY OF STUDENTS INCREASE RECENTLY TYPE END TO 36 OR 37,000, BUT AGAIN IT GOES TO RO1s. THEY ACTUALLY GO INTO FOOD PANTRIES AND DOING SOME THINGS THAT I'M SO SHOCKED AND THE OTHER BIG PORTION IS THAT NOW ON A LOT OF THINGS WE DO AS STRUCTURAL BIOLOGIST AND CRYOEM, WE CAN'T FIND PEOPLE ANYWHERE, THOAR GOING TO POST DOCTORALS, NOW, THEY SAID THAT $55,000 AS A TYPE END IS NOT GOING TO CUT IT MUCH AND THEY'VE BEEN GOING TO OTHER PLACES AND WE DISCUSS THIS AT SEVERAL MEETINGS THAT WHEN WE SEE EACH OTHER IN PERSON AGAIN THAT WE CANNOT FIND PEOPLE AND THE REASON IS THE INFLATION, COST OF LIVING AND ALL THAT. I WILL BRING IT UP WITH WHAT WE ARE SEEING HERE ON OUR SIDE. THANK YOU. >> THANKS FOR BRINGING THOSE POINTS UP. QUITE TROUBLING. >> AMY? >> TWO THINGS, FIRST OF ALL, I THINK SOMETIMES EARLY INVESTIGATORS DON'T REALIZE THAT CAN DO THINGS LIKE APPLY FOR ADMINISTRATIVE SUPPLEMENTS TO GET INSTRUMENTS THEY NEED AND SO MAYBE SOME MORE DISSEMINATION OF OTHER WAYS TO GET MONEY ON TOP OF THE LIMITED BUDGET BECAUSE I AGREE WITH SQUIRE, I DON'T FEEL LIKE IT'S CHAIMPLE THAD MUCH OVER THE YEARS SO THOSE TYPES OF THINGS MIGHT BE MORE PUBLICIZED. THE OTHER THING I WAS WONDERING WHICH HAS PROBABLY BEEN DISCUSSED BEFORE BUT WHY DOES NIGMS HAVE PREDOCTORAL FELLOWSHIPS? >> WE HAVE DIVERSITY F38. >> RIGHT, BUT IF YOU WANT TO APPLY FOR AN F--IS IT AN F30? >> IT WAS AN F31. WE'RE REQUIRED TO GIVE THEM FOR A COUPLE OF YEARS, WHAT WE FOUND WAS FIRST OF ALL THAT, YOU KNOW IT'S A SET POOL OF MONEY SO THAT MONEY WAS COMING OUT OF THE T32s AND WE THINK IT'S MUCH MORE VALUABLE FOR US TO INVEST OUR MONEY IN INSTITUTIONAL TRAINING GRANTS BECAUSE WE HAVE SO MUCH OF A MULTIPLIER EFFECT IN GIVING INSTITUTIONAL TRAINING GRANT RELATIVE TO JUST AN INDIVIDUAL FELLOWSHIP. FURTHER MORE, I WILL TELL YOU THAT WHAT WE REALLY WANTED TO DO IF WE'RE GOING TO GIVE F31s WAS TO GIVE IT TO PEOPLE WHO OTHERWISE WOULD NOT HAVE BEEN ABLE TO YOU KNOW CONDUCT GRADUATE RESEARCH OR CONDUCT IT IN THE LAB THEY WANTED TO WORK IN, BUT THAT'S NOT AT ALL WHAT WE SAW. WHAT WE SAW WAS THAT BASED ON WHAT CAME OUT OF THE STUDY SECTIONS, THE PEOPLE WHO WERE GETTING THEM WERE PEOPLE IN EXTREMELY WELL FUNDED LABS AT EXTREMELY WELL FUNDED INSTITUTIONS WHO WERE ABSOLUTELY GOING TO HAVE NO PROBLEM CONDUCTING, YOU KNOW THEIR GRADUATE RESEARCH IN THE LAB, THEY WANT TO DO IT IN, WITHOUT THE FELLOWSHIP, SO IT WAS BASICALLY, WE WERE GIVING MONEY TO PUT A LINE ON SOMEONE'S CV, THAT'S WHAT IT ENDED UP BEING AND THERE'S JUST--WE COULD NOT RATIONALIZE THOSE 2 THINGS FOR CONTINUING TO GIVE F31s. IF--YOU KNOW IF WE HAD BEEN GIVING THEM TO PEOPLE WHO AGAIN WOULDN'T HAVE BEEN ABLE TO CONDUCT RESEARCH OR WHERE THEY WANTED TO DO IT WITHOUT THE FELLOWSHIP, I THINK WE WOULD HAVE THOUGHT VERY HARD ABOUT CONTINUING IT, BUT IT JUST--IT JUST DID NOT SEEM MONEY WORTH GIVING. JUST TO BE FRANK. THAT'S WHAT WE SAW. >> THAT MAKES SENSE BUT THAT'S ANOTHER WAY TO HELP DEFRAY THESE EXPENSES THAT ARE GETTING HIGHER AND HIGHER. >> AGAIN, YOU KNOW I THINK THAT GOES BACK TO THE POINT I WAS JUST MAKING THAT, IF THE FELLOWSHIPS WERE GOING TO LABS THAT WERE OPERATING ON A SINGLE GRANT, I WOULD AGREE WITH YOUR POINT BUT THEY WEREN'T, THEY WERE GOING TO LABS THAT HAD, YOU KNOW HHMI, PLUS MULTIPLE GRANTS PLUS, YOU KNOW WHATEVER ELSE AND IT WAS MORE MONEY TO LABS THAT ALREADY HAD A LOT OF MONEY TO BE HONEST. >> LAURA? >> SO THE TYPE END ISSUE I KNOW PUSHES ON ALL OF US IT SOUNDS LIKE. SO WE LOOKED RECENTLY, WE'RE ALWAYS--WE CHECKED TWICE A YEAR BECAUSE THE STUDENTS PUSH US TO CHECK TWICE A YEAR. WHERE DO WE RANK NATIONALLY? SO WE LOOK AT BIG INSTITUTIONS AND LAND AND GET A SENSE OF PEER INSTITUTIONS, I WONDER IF YOU MAY HAVE SHARED WITH US BEFORE AND I FORGET, WHETHER WE HAVE IDEA STATE VERSUS NONIDEA STATE AFFILIATED INSTITUTIONS IN TERMS OF WHERE TYPE ENDS ARE LANDING BECAUSE I-- >> THAT'S A GOOD QUESTION, I HAVE NOT SEEN THOSE DATA. WE CAN LOOK INTO WHETHER THEY'RE AVAILABLE. I'M NOT SURE THAT WE CAN GET THEM EASILY OURSELVES BECAUSE YOU KNOW THOSE ARE INSTITUTIONAL DECISIONS. WE WOULD HAVE TO ACTUALLY GO THROUGH AND SEE WHAT PEOPLE BEING PAID OFF OF GRANTS TO DO IT. IT MAY BE POSSIBLE THAT WE COULD DO IT BUT-- >> YEAH, IT MIGHT BE REALLY TEDIOUS, BUT PART OF THE REASON I ASK IS MY GUT FEELING, YOU KNOW OBVIOUSLY STUDENTS ARE HUMAN AND WE ROUTINELY LOSE THEM TO HIGHER STIPEND PLAYING, PAYING, PLACES. AND THEN RIGHT BEHIND THAT IS A FEW OFFSET FEES WHICH IS SOME KIND OF BLACK HOLE HERE THAT I JUST CAN'T FIGURE OUT. YOU KNOW IT'S ALLOWABLE IN CERTAIN WAYS, NOT OTHER WAYS SO WE JUST DIG AROUND IN THERE BUT I CAN'T FIND GOOD SOLUTIONS, SO I'M JUST CURIOUS BECAUSE IT FEELS LIKE IT MIGHT BE PUSHING AGAINST SOME OF THE NIGMS GOALS. IF WE HAVE AN EFFLUX OF OPPORTUNITIES FROM IDEA STATE TO INSTITUTIONS TO OTHER AREAS BECAUSE THERE'S JUST SUCH A FABULOUS TALENT POOL. >> ABSOLUTELY. >> I THINK THE EFFORT IN THE EQUATION OF COURSE IS THE COST OF LIVING WHICH, YOU KNOW WOULD BE SOMETHING THAT'S STUDENTS PROBABLY SHOULD BE EDUCATED IN BECAUSE IF YOU GO TO A--YOU KNOW. >> YEAH, WE PUT THAT-- >> THE SCHOOLS, THE COST OF LIVING COULD EASILY BE 50% OR MORE, MORE THAN WHAT IT IS, YOU KNOW SAY IN MORGAN TOWN, RIGHT? >> ABSOLUTELY. WE'RE TRYING TO HIT HARD ON ALL OF THOSE. SO I'M JUST CURIOUS PARTLY TO KEEP-- >> WE CAN LOOK AT IT. >> --STUDENTS INTO--INTO THE PROGRAM. TO THE OTHER POINT YOU TALKED ABOUT IN TERMS OF NIGMS INDIVIDUAL FELLOWSHIPS, WE GET IT, YEE JUST DID AN ANALYSIS OF ALL OUR SUMMARY STATEMENTS BECAUSE OUR INDIVIDUAL FELLOWSHIP SUBMISSIONS WE'VE PUSHED UP AND UP, THAT ARE HIT RATE, I WILL ADMIT IS FLAT. RIGHT? SO NOW WE HAVE TO DEAL WITH COMPETITIVENESS AND WHEN WE ELECTRIC AT THOSE CRITIQUES IT WAS ALMOST ENTIRELY DRIVEN BY FUNDING OF THE PI, IT WAS SO INTERESTING, AND SO SIMPLE AND A LITTLE FRUSTRATING IN A WAY. BUT FRUSTRATION'S GONE, NOW WE'RE JUST GOING TO FIGURE IT OUT BUT THAT'S THE DRIVING FORCE. >> THAT MAKES MY POINT EXACTLY, THE MORE MONEY THE PI HAS, THE MORE LIKELY THEIR STUDENT IS TO GET A FELLOWSHIP. >> THAT IS LITERALLY TRUE AND YOU JUST CONFIRMED, YOU KNOW-- >> IT WAS REALLY STRAIGHT FORWARD. >> YEAH. >> IN A WAY WE WERE HOPING WAS NOT THE CASE. >> AGREED. AGREED. >> BUT IT IS. >> DANIELLE? >> SO I FEEL LIKE I ALWAYS HAVE THESE LONG STANDING QUESTIONS ABOUT WHAT WE'RE PAYING IN LONG STANDING SALARY SUPPORT AND THESE UNIVERSITIES BUT LEADING OFF THAT ASIDE AND LEADING OFF THE OF HOW MUCH COSTS ARE INCREASING IS THERE SOME KIND OF PLAN TO THINK ABOUT INCREASING APPROPRIATIONS AND KIND OF MARKETING THE IMPACT OF NIGMS RESEARCH IN A WAY THAT--I'M HAPPY TO VOLUNTARY LABOR ON THIS ANALYSIS TO MAKE IT MORE CLEAR TO CONGRESS, THE IMPABLGHT OF THIS MONEY TO TRY TO RAISE THE APPROPRIATIONS? SO THAT'S -- >> SO THAT'S NOT SOMETHING WE CAN COMMENT ON OR DO, IT'S NOT PART OF OUR JOB TO INFLUENZ APPROPRIATIONS, WE HAVE TO USE WHAT CONGRESS GIVES US. LUCKILY THEY HAVE BEEN GENEROUS OVER THE PAST 5 YEARS OR SO SO THAT'S BEEN QUITE POSITIVE BUT WE CAN'T--WE CANNOT ADDRESS THAT PARTICULAR ISSUE OURSELVES. >> NEXT QUESTION. PRESUMABLY CONGRESS LIKE TAKES INFORMATION AND MAKES A DECISION BASED ON HOW VALUABLE THEY THINK THAT INVESTMENT IS. WHAT IS THE ORGANIZATION THAT INFORMATION PRESUMABLY, INFORMATION PROVIDED TO CONGRESS AND THAT HELPS MACK A DETERMINE NATION. >> I THINK THERE ARE SEVERAL PEOPLE ON COUNCIL WHO HAVE HAD OR HAVE ROLES IN PROFESSIONAL SOCIETIES FOR EXAMPLE. I THINK TERRY'S GOT HER HAND UP, MAYBE SHE HAS A COMMENT. >> THIS IS MY ONLY-- >> JUST A GENERAL STATEMENT THAT MANY SCIENTIFIC SOCIETIES HAVE COMMITTEES SUCH AS A PUBLIC AFFAIRS ADVISORY COMMITTEE THAT MEMBERS CAN JOIN AND THEY FREQUENTLY WILL DO VERY POSITIVE HILL DAYS FOR MEDICAL SCIENCE AND NOT JUST NIH AND ASSESS EOE, AND HOW THOSE GO TOGETHER AND HOW THAT PUT IT TOGETHER AND PARTICULARLY FUNDAMENTAL SCIENCE, AND IF YOU WANT TO CONTACT ME DIRECTLY, I CAN GET YOU INFORMATION AND GET YOU INVOLVED, I DON'T WANT TO GO TOO FAR BUT THERE'S A LOT OF SOCIETIES. >> PART OF MY JOB. >> OKAY, AMERICAN SOCIETY FOR BIOSOCIETY FOR IN LEC BAR BIOLOGY HAS A PARTICULARLY ROBUST COMMITTEE I USED TO CHAIR IT, I'M ROTATING OFF THE COMMITTEE AND THEY JUST DID A HILL DAY AND I'LL ADD THESE SOCIETIES OFTEN BRING IN STUDENTS AND POST DOCS AND TRAIN THEM ABOUT THE APPROPRIATION PROCESS ALONG WITH FACULTY AND SOMETIMES PEOPLE FROM INDUSTRY SO IT IS A ROBUST SYSTEM TO EDUCATE OUR ELECTED OFFICIALS ABOUT THE IMPORTANCE OF FUNDMENTAL RESEARCH FOR THE ECONOMY FOR PUBLIC HEALTH, SO, WE ARE THE BEST ADVOCATES FOR NIH OURSELVES. >> THANKS. AND TO YOUR POINT DANIELLE, TO YOUR COMMENT ABOUT SALARY SUPPORT, I AGREE WITH YOU ENTIRELY. THAT IS AN ISSUE. I HAVE TRIED TO PUSH ON THIS AS MUCH AS I CAN, IT'S NOT CLEAR HOW MANY LEVERS WE HAVE TO AFFECT IT BUT I THINK IT IS A DRAG ON THE SYSTEM IS THE AMOUNT OF SALARY THAT--THE AMOUNT OF SALARY SUPPORT THAT MANY INVESTIGATORS ARE BEING REQUIRED TO TAKE OFF THEIR GRANTS AS OPPOSED TO WHAT IT USED TO BE WHICH IS MORE INSTITUTIONAL SUPPORT FOR SALARY. SO AGAIN, I THINK IT'S AN AREA THAT MORE DATA ARE NEEDED TO UNDERSTAND FULLY. >> IF THERE'S ANYTHING I CAN DO. >> GOOD. THANK YOU. THANK YOU. PETER? >> YEAH, THANKS. AT THE RISK OF SORT OF BEATING THIS TOO MUCH, I JUST WANT TO SAY THAT IT'S GREAT TO HEAR THAT APPROPRIATIONS ARE INCREASING, THAT'S WONDERFUL, WE ALWAYS WANT TO DO NEW THINGS WHEN WE HAVE NEW RESOURCES AND I JUST WANT TO CONVEY THAT I THINK BASIC SCIENCES IN GENERAL ARE REALLY SUFFERING AND THAT BEING ABLE TO INVEST ACROSS THE BOARD IN INCREASING THE AMOUNT OF FUNDING TO EXISTING GRANTS WOULD BE REALLY WISE DECISION ALTHOUGH NOT NECESSARILY, YOU KNOW AS EXCITING AS LAUNCHING NEW THINGS BUT IT'S REALLY TOUGH. THERE ARE SOME INSTITUTIONS THAT HAVE BEEN FANTASTIC AT RAISING MONEY FOR PHILANTHROPY FOR BASIC SCIENCE IT'S IT'S A HARD SELL FOR OTHER AREAS OF BIOMEDICAL RESEARCH. >> ABSOLUTELY. AND POINT WELL TAKEN. AND 1 OF THE THINGS IN THE FUNDING LEVELS IS THAT THAT IS A PRIORITY FOR US IN THE MIRA PROGRAM IS TO FLOAT ALL BOATS AND TO BRING THE MINIMUM LEVEL OF FUNDING UP SO, YOU KNOW FROM THE START, WE HAVE SAID THAT TO BE 250, I MEAN SQUIRE WAS NIGHT, RO1s USED TO BE 190 AND NOW IT'S 210 BUT STILL WELL BELOW WHAT YEAR SHOOTING FOR IN MIRA, THE FLOOR UP EVEN FURTHER, I THINK THAT WOULD BE FOR THE GOOD SO,--BUT AGAIN, I DO WANT TO MAKE CLEAR THAT OUR FOCUS IS AT THE SORT OF--THE LEVEL OF THE TIDE NOT THE LEVEL--THE LEVEL OF LOW TIDE, NOT THE LEVEL OF HIGH TIDE, IF YOU WILL, RIGHT? SO INVESTIGATORS WHO ALREADY HAVE, YOU KNOW PRETTY DIG 95 CANT AWARD CHESTS AND JUST WANT TO MAINTAIN THE SAME NUMBER OF STAFF THEY HAVE IN THEIR LAB, YOU KNOW AT 15 OR 20 OR WHATEVER THEY HAVE, WE'RE NOT TERRIBLY SYMPATHETIC TO THAT, I'M MUCH MORE SYMPATHETIC TO SOMEONE TRYING TO RUN THEIR LAB OFF OF 1 GRANT WITH A MODEST SIZE LAB THAT WE COULD BRING THAT LEVEL UP HIGHER. PAUL? >> YEAH, I JUST HAD PART PERSPECTIVE, PART QUESTION ON THIS TOPIC OF TRAINEE SUPPORT THAT I THINK ALSO RELATES TO THE OVERALL GOAL OF ENHANCING DIVERSITY IN THE SCIENTIFIC WORKFORCE AND THAT IS IN 1 ISSUE THAT I NEVER REALLY APPRECIATED UNTIL BECOMING A PI WAS WHERE INTERNATIONAL STUDENTS AND TRAINEES FIT INTO OVERALL TRAINING SUPPORT ISSUES AT LEAST HERE IN UTAH, 25% OF OUR GRADUATE STUDENTS IN HEALTH SCIENCES ARE INTERNATIONAL AND THEY ARE NOT ELIGIBLE FOR T32 AND OTHER THINGS AND TO SOME EXTENT ALTHOUGH THEY CAN BE SUPPORTED OFF RESEARCH GRANTS ARE A LITTLE BIT INVISIBLE TO THE NIH'S RADAR AND I ASSUME THAT'S PROBABLY NOT GOING TO CHANGE ANYTIME SOON, SO WE'VE BEEN LOOKING FOR WAYS HERE INSTITUTIONALLY TO MOBILIZE INTERNAL SUPPORT TO ALLIFE ON EARTH TO EXISTING T32s TO HELP SUPPORT THEM BUT I GUESS THIS RELATES TO DIVERSITY IN BETTER WAYS BECAUSE I ASSUME MANY INSTITUTIONS ARE KIND OF WHERE INTERNATIONAL STUDENTS ARE COMING FROM IS SHIFTING A BIT AND WE'VE SEEN A LOT OF TRENDS TOWARDS COUNTRY THAT THESE ARE STUDENT FIST THEY CONTINUE IN THE PIPELINE BECOME U.S. RESIDENTS AND BECOME U.S. CITIZEN SO CERTAINLY, OUR 1 CONDUIT TOWARDS ADDRESSING AN OVERALL CHALLENGE THAT WE CERTAINLY BRING TREMENDOUS DIVERSITY THERE, SO, MY QUESTION IS WITHIN CURRENT CONSTRAINTS THAT EXIST AND MAY OR MAY NOT BE LIKELY TO CHANGE, ARE THERE OTHER CREATIVE WAYS THAT NIGMS AND NIH MORE BROADLY CAN LOOK TO SUPPORT AND ENHANCE THE ROLE THAT INTERNATIONAL TRAINEES PLAY IN OVERALL WELCOMER FORCE DEVELOPMENT. >> YEAH, I THINK THOSE ARE FREQUENT TOPICS OF DISCUSSION, THAT'S A REALLY GOOD POINT, PAUL, THERE ARE SOME PROGRAMS LIKE TD PARENT K99 R00 WHERE THAT CAN SUPPORT INTERNATIONAL STUDENTS. THE NRSA, THE T32s, THE Fs, THAT'S IN LAW THAT THEY ARE FOR U.S. CITIZEN AND PERMANENT PRESIDENTS SO CAN'T CHANGE THAT. YOU KNOW I THINK THE BALANCE HERE ON YOUR POINTS ARE EXTREMELY WELL TAKEN, THE BALANCE OF COURSE IS THAT 1 DOESN'T WANT TO IF YOU'RE TALKING ABOUT DIVERSITY FOR EXAMPLE, FOCUS ON THAT AS THE SOLUTION AS OPPOSE TO SUPPORTING UNDERREPRESENTED STUDENTS WHO ARE, YOU KNOW U.S. BORN BECAUSE, YOU KNOW IT'S PERCEIVED AS BEING EASIER TO DO THE FORMER THAN THE LATTER, WE DON'T WANT TO FALL INTO THAT TRAP, I THINK SO WE NEED TO MAKE SURE WE BALANCE THOSE 2 THINGS. OTHER COMMENTS? ANGELA? >> YEAH THIS, IS MOSTLY FOR OBSERVATION AND I HAVEN'T YET BEEN ABLE TO CRAFT IT INTO AN INTERESTING QUESTION, BUT IT'S AN INTERESTING TOPIC WHICH IS TO THINK ABOUT THE LOCAL ENVIRONMENT OF THE PRIVATE SECTOR AND HOW THAT'S DIFFERENT ACROSS THE COUNTRY AND HOW IT MIGHT BE INFLUENCING TRAINING BOTH IN TERMS OF TRAINING GOALS AND ALSO ALUMNI NETWORK ACCESS BECAUSE THIS SEEMS TO BE A REALLY BIG DRIVER OF POST GRADUATION PLACEMENT AND GIVEN HOW CLUSTERED PRIVATE SECTOR OPPORTUNITIES ARE ACROSS THE COUNTRY, I COULD IMAGINE THAT MIGHT JUST BE A PIECE THAT'S SORT OF UNDERAPPRECIATED AND HOW IT'S IMPACTING T32S AND OTHER KINDS OF TRAINING PROGRAMS. SO I JUST WANTED TO PUT THAT OUT THERE, YOU KNOW I'M IN BOSTON SO THERE'S A HUGE LIFE SCIENCES PRIVATE SECTOR HERE AND IT'S--IT'S VERY VISIBLE TO THE STUDENTS BOTH IN TERMS OF SALARY PRESSURES AND OPPORTUNITIES POST GRADUATION SO I'M NOT SURE WHAT KIND OF ROLE NIGMS COULD PLAY IN ANALYZING THAT LAND CAPE AND THINKING ABOUT IT BUT IT'S VERY REAL. >> IT IS A VERY GOOD POINT AND IT IS SOMETHING WE'RE VERY INTERESTED IN BECAUSE OF OUR FOCUS ON UNDERRESOURCED STATES AND INSTITUTIONS LIKE THE IDEA STATES OR MINORITY SERVING INSTITUTIONS ACROSS THE COUNTRY AND TRYING TO BUILD THAT ENTREPRENEURIAL CULTURE AND THAT BIOTECH SECTOR AND THOSE PLACES, I THINK YOUR POINT FEEDS THAT QUESTION EXACTLY, HOW DO YOU--HOW DO YOU GET THE BENEFITS THAT YOU HAVE IN BOSTON OR SAN FRANCISCO, YOU KNOW IN OTHER PLACES AND YOU POINTED TO IT, VERY SPECIFIC 1 THAT BENEFIT FOR STUDENTS IN THERE, SAY, INTERNSHIPS OR POTENTIAL JOB PROSPECTS WHICH IS A VERY GOOD 1 BUT ALL KINDS OF CIALGHT 1S AS WELL, RIGHT? >> ABSOLUTELY AND I THINK IT'S JUST SOMETHING THAT'S HARD FOR NECESSARILY ACADEMIC INSTITUTIONS TO ASSESS SYSTEMATICALLY AND LONGITUDINALLY AND THOUGHTFULLY SO I DON'T KNOW, IT MIGHT BE A GOOD PLACE TO THINK ABOUT HOW TO ASK THE RIGHT QUESTIONS AND GET THE RIGHT DATA. >> ABSOLUTELY. LAURA DID YOU HAVE A COMMENT? >> JUST A FOLLOW UP TO PAUL'S COMMENTS AROUND INTERNATIONALLY STUDENTS WHICH I THOUGHT WERE SPOT-ON AND 1 STRATEGY THAT WE'VE UNDERTAKEN HERE WAS AS ADDITIONAL T32s HIT AND IT LIGHTENED UP, A PUSH ON MY OFFICE BUDGET A LITTLE, WE CREATED A PEER REVIEW INTERNATIONAL INDIVIDUAL FELLOWSHIP PROGRAM OUT OF THE OFFICE. AND THAT WAS IN PART TO--BECAUSE THOSE ARE FABULOUS STUDENTS AND AS WE ALL KNOW NOT QUITE AS MANY OPPORTUNITIES AND THEY WERE FEELING OUT OF THE MAIN STREAM AS THEIR COLLEAGUES WERE PARTICIPATE NOTHING WRITING GROUPS AND PUTTING IN THEIR INDIVIDUAL FELLOWSHIPS AND THERE WEREN'T EQUAL OPPORTUNITIES. SO THAT'S BEEN REALLY HIGHLY SUBSCRIBED AS YOU MIGHT IMAGINE AND WE MADE IT MATCH AS IF THEY HAD GONE EXTERNAL AND PUSHED HARD ON REALLY ROBUST PEER REVIEW FOR THE EDUCATIONAL COMPONENT OF THE EXERCISE AS WELL. SO IT DOESN'T SOLVE THE PROBLEM IN ANY WAY BUT IT WAS A WAY WE WERE TRYING TO PICK AT IT A LITTLE BIT. YEAH, THAT'S A GREAT IDEA. OF COURSE, THERE ARE SOME INTERNATIONAL OPPORTUNITIES YOU KNOW PEOPLE'S HOME COUNTRIES OR THE HUMAN FRONTIER SCIENCE PROGRAM WHICH NIH ACTUALLY CONTRIBUTES FUND BEING TOWARDS, I'M NOT SURE IF THAT'S WELL KNOWN BUT 1 OF THE FUNDERS OF HFSP IS THE NIH, YOU KNOW, SO 1 COULD DO SOMETHING LIKE THAT WITH THOSE PROGRAMS AS WELL, IT'S A VERY GOOD IDEA. >> GREAT. WELL, THIS IS A VERY ROBUST DISCUSSION AT THE END AND I APPRECIATE THAT. WE ARE A LITTLE EARLY IN ENDING. THERE WAS A MOTION TO MAYBE START THE CLOSED SESSION A LITTLE EARLY, MAYBE 1:15. WOULD THAT BE A PROBLEM FOR ANYBODY IF WE STARTED AT 1:15 INSTEAD OF 1:30? LET PEOPLE OUT A BIT EARLIER? OKAY, SO WHY DON'T WE START AT 1:15 AND JUST REMEMBER, PLEASE THAT THAT'S A DIFFERENT LINK THAN THIS 1 BECAUSE IT'S THE CLOSED SESSION. SO DON'T--DON'T TRY TO COME BACK TO THIS MEETING, IT WILL BE CLOSED. THANK YOU EVERYONE FOR THE GREAT DISCUSSION, AND EVERYONE WHO HELPED ORGANIZE THIS, AND ALL OF YOU FOR DOING ALL THIS HARD WORK, SO WE WILL SEE YOU AGAIN AT 1:15 CLOSED SESSION.