1 00:00:07,960 --> 00:00:08,680 >>WELCOME TO ALL THE VIRTUAL 2 00:00:08,680 --> 00:00:11,400 COUNCIL MEMBERS AND GUESTS TO 3 00:00:11,400 --> 00:00:12,840 THE 231st MEETING OF THE 4 00:00:12,840 --> 00:00:19,160 NATIONAL ADVISORY DENTAL AND 5 00:00:19,160 --> 00:00:19,520 CRANIOFACIAL. 6 00:00:19,520 --> 00:00:22,600 I'M THE DIRECTOR EXECUTIVE 7 00:00:22,600 --> 00:00:23,560 SECRETARY OF THE COUNCIL 8 00:00:23,560 --> 00:00:24,040 MEETING. 9 00:00:24,040 --> 00:00:26,280 I'M GOING TO BEGIN WITH A FEW 10 00:00:26,280 --> 00:00:28,560 INFORMATIONAL AND PROCEDURAL 11 00:00:28,560 --> 00:00:28,840 ITEMS. 12 00:00:28,840 --> 00:00:30,200 TODAY'S PROCEEDINGS ARE BEING 13 00:00:30,200 --> 00:00:32,800 CONDUCTED VIA ZOOM WITH A VIDEO 14 00:00:32,800 --> 00:00:34,720 CAST REVIEWING BY THE PUBLIC. 15 00:00:34,720 --> 00:00:36,480 WE WILL NOT BE TAKING QUESTIONS 16 00:00:36,480 --> 00:00:37,960 OR COMMENTS FROM THE PUBLIC 17 00:00:37,960 --> 00:00:41,800 DURING THE LIVE BROADCAST BUT WE 18 00:00:41,800 --> 00:00:44,080 ENCOURAGE YOU TO SEND QUESTIONS 19 00:00:44,080 --> 00:00:45,720 OR COMMENTS UNTIL 20 00:00:45,720 --> 00:00:49,440 SEPTEMBER 30th, THAT ARE 21 00:00:49,440 --> 00:00:50,920 SUBMITTED TO AN NIDCR E-MAIL 22 00:00:50,920 --> 00:00:52,920 ADDRESS DISPLAYED AT THE END OF 23 00:00:52,920 --> 00:00:53,760 THE SESSION. 24 00:00:53,760 --> 00:00:55,600 WE ASK THAT COUNCIL MEMBERS AND 25 00:00:55,600 --> 00:00:57,360 STAFF PLEASE MAKE SURE THAT YOUR 26 00:00:57,360 --> 00:00:59,120 MICROPHONES ARE SET ON FUTURE 27 00:00:59,120 --> 00:01:00,760 AND WHEN SPEAKING, PLEASE 28 00:01:00,760 --> 00:01:01,920 IDENTIFY YOURSELVES TO ENSURE 29 00:01:01,920 --> 00:01:05,680 THE ACCURACY OF OUR RECORDS. 30 00:01:05,680 --> 00:01:07,040 IF ANYONE PARTICIPATING IN THE 31 00:01:07,040 --> 00:01:08,880 ZOOM VIDEO CONFERENCE NEEDS HELP 32 00:01:08,880 --> 00:01:12,520 WITH TECHNICAL PROBLEMS, TIM, 33 00:01:12,520 --> 00:01:14,840 AND RUSSELL FROM OUR I.T. 34 00:01:14,840 --> 00:01:16,160 SUPPORT TEAM, WILL BE AVAILABLE 35 00:01:16,160 --> 00:01:17,440 TO ASSIST YOU. 36 00:01:17,440 --> 00:01:19,240 AND THEY HAVE PROVIDED THEIR 37 00:01:19,240 --> 00:01:23,000 CONTACT INFORMATION IN THE 38 00:01:23,000 --> 00:01:23,760 CHATBOX. 39 00:01:23,760 --> 00:01:28,920 SO, THE FIRST ORDER OF BUSINESS 40 00:01:28,920 --> 00:01:31,120 WILL BE THE APPROVAL OF THE 41 00:01:31,120 --> 00:01:33,000 MINUTES FROM THE PREVIOUS 42 00:01:33,000 --> 00:01:34,000 COUNCIL MEETING. 43 00:01:34,000 --> 00:01:36,080 THE MINUTES FROM THE MAY 2022 44 00:01:36,080 --> 00:01:37,520 MEETING WERE MADE AVAILABLE TO 45 00:01:37,520 --> 00:01:39,440 COUNCIL MEMBERS FOR THEIR 46 00:01:39,440 --> 00:01:39,760 REVIEW. 47 00:01:39,760 --> 00:01:41,280 ARE THERE ANY COMMENTS OR 48 00:01:41,280 --> 00:01:43,440 CORRECTIONS FROM COUNCIL MEMBERS 49 00:01:43,440 --> 00:01:48,880 FOR THE MAY '22 COUNCIL MEETING 50 00:01:48,880 --> 00:01:52,800 MINUTES? 51 00:01:52,800 --> 00:01:53,440 NO COMMENTS. 52 00:01:53,440 --> 00:01:55,080 WOULD A MEMBER OF COUNCIL LIKE 53 00:01:55,080 --> 00:01:57,920 TO MAKE A MOTION TO APPROVE THE 54 00:01:57,920 --> 00:01:58,280 MINUTES? 55 00:01:58,280 --> 00:02:01,920 >> SO MOVED. 56 00:02:01,920 --> 00:02:02,160 JACK. 57 00:02:02,160 --> 00:02:02,960 >> Lynn M. King: WOULD SOMEONE 58 00:02:02,960 --> 00:02:04,680 LIKE TO SECOND THE MOTION? 59 00:02:04,680 --> 00:02:09,200 >> SECOND, HAL. 60 00:02:09,200 --> 00:02:10,040 >> Lynn M. King: ALL IN FAVOR. 61 00:02:10,040 --> 00:02:15,040 >> AYE. 62 00:02:15,040 --> 00:02:18,720 >> Lynn M. King: AND ANY OPPO 63 00:02:18,720 --> 00:02:19,560 OPPOSED? 64 00:02:19,560 --> 00:02:20,880 NO OPPOSED. 65 00:02:20,880 --> 00:02:22,520 SO AFTER THAT BRIEF 66 00:02:22,520 --> 00:02:23,560 INTRODUCTION, I WILL NOW TURN 67 00:02:23,560 --> 00:02:27,200 THE MEETING OVER TO THE Dr. 68 00:02:27,200 --> 00:02:33,160 D'SOUZA FOR THE DIRECTOR'S 69 00:02:33,160 --> 00:02:33,400 REPORT. 70 00:02:33,400 --> 00:02:34,960 >> THANK YOU, LYNN. 71 00:02:34,960 --> 00:02:38,880 AND I WANT TO SAY REALLY GREET 72 00:02:38,880 --> 00:02:42,520 EVERYONE WARMLY AND MY STAFF AT 73 00:02:42,520 --> 00:02:44,560 NIDCR STAFF WHO HAVE JOINED THIS 74 00:02:44,560 --> 00:02:47,560 SESSION AS WELL AS ALL OUR 75 00:02:47,560 --> 00:02:48,880 STAKEHOLDER GROUPS AND GRANTEES 76 00:02:48,880 --> 00:02:50,800 AND TRAINEES. 77 00:02:50,800 --> 00:02:55,000 IT'S BEEN A VERY INTENSELY 78 00:02:55,000 --> 00:02:56,520 PRODUCTIVE AND REWARDING TIME. 79 00:02:56,520 --> 00:02:58,520 FOR ME, OCTOBER WOULD MARK TWO 80 00:02:58,520 --> 00:03:00,400 YEARS OF BEING HERE AND I MUST 81 00:03:00,400 --> 00:03:02,720 SAY, THE HIGHLIGHT OF MY TERMS 82 00:03:02,720 --> 00:03:06,400 SO FAR HAS BEEN GETTING TO KNOW 83 00:03:06,400 --> 00:03:08,280 OUR COMMUNITY WELL. 84 00:03:08,280 --> 00:03:11,760 THE TRIPS TO SCHOOLS AND TO 85 00:03:11,760 --> 00:03:12,680 ORGANIZATIONS GIVING TALKS HAS 86 00:03:12,680 --> 00:03:14,440 FOR JENNIFER AND ME, BECAUSE SHE 87 00:03:14,440 --> 00:03:16,240 PARTNERS WITH ME IN THIS 88 00:03:16,240 --> 00:03:17,880 JOURNEY, HAS BEEN VERY, VERY 89 00:03:17,880 --> 00:03:19,960 MEANINGFUL AND REWARDING. 90 00:03:19,960 --> 00:03:21,520 WE'VE BEEN GREETED WARMLY AND WE 91 00:03:21,520 --> 00:03:26,880 HAVE A SENSE AND A FINGER ON THE 92 00:03:26,880 --> 00:03:28,720 PULSE AND THE PANDEMIC HAS TAKEN 93 00:03:28,720 --> 00:03:29,320 ITS TOLL. 94 00:03:29,320 --> 00:03:30,920 IT DOESN'T MEAN OUR PROFESSION 95 00:03:30,920 --> 00:03:32,880 AND EDUCATORS AND CLINICIANS ARE 96 00:03:32,880 --> 00:03:35,320 NOT UP TO THE TASK, I THINK IT'S 97 00:03:35,320 --> 00:03:38,520 POINTED OUT SO MANY NEW 98 00:03:38,520 --> 00:03:40,160 DIRECTIONS FOR US AS A COMMUNITY 99 00:03:40,160 --> 00:03:42,960 FOR ORAL HEALTH SCIENTISTS 100 00:03:42,960 --> 00:03:43,240 CLINICIANS. 101 00:03:43,240 --> 00:03:45,200 SO WHAT I WANT TO DO TODAY, IS 102 00:03:45,200 --> 00:03:47,400 TO START OFF WITH THE OVERVIEW 103 00:03:47,400 --> 00:03:49,480 INTRODUCTION OF THANKING 104 00:03:49,480 --> 00:03:51,040 INDIVIDUALS, WELCOMING NEW FOLKS 105 00:03:51,040 --> 00:03:53,480 ON BOARD AND THEN TO MOVE ON TO 106 00:03:53,480 --> 00:03:55,400 GIVING YOU A STATE OF WHERE WE 107 00:03:55,400 --> 00:03:58,480 ARE AS A NATION, WHAT ARE THE 108 00:03:58,480 --> 00:04:00,040 PRIORITIES OF THIS 109 00:04:00,040 --> 00:04:01,920 ADMINISTRATION AND HOW THEY 110 00:04:01,920 --> 00:04:05,040 ACTUALLY INFLUENCE WHAT NIH DOES 111 00:04:05,040 --> 00:04:06,120 AND CERTAINLY NIDCR AS WELL. 112 00:04:06,120 --> 00:04:10,960 I PUT IT IN THE CONTEXT WITH THE 113 00:04:10,960 --> 00:04:12,960 PANDEMIC AND HOW TODAY WE STAND 114 00:04:12,960 --> 00:04:16,160 READY TO REPORT ON SOME OF THE 115 00:04:16,160 --> 00:04:17,240 INVESTMENTS AND NIDCR MADE AND 116 00:04:17,240 --> 00:04:19,600 IT WAS A VERY QUICK PIVOTING, 117 00:04:19,600 --> 00:04:22,280 THE NIMBLENESS, THE CREATIVE TEE 118 00:04:22,280 --> 00:04:23,960 AND INNOVATION SHOULD COME 119 00:04:23,960 --> 00:04:24,800 THROUGH TO YOU ALL. 120 00:04:24,800 --> 00:04:26,480 AND THE KEY MESSAGE IS TO THINK 121 00:04:26,480 --> 00:04:29,000 THAT DESPITE THE TRAGEDY OF THE 122 00:04:29,000 --> 00:04:30,680 PANDEMIC, THAT THE LESSONS IT 123 00:04:30,680 --> 00:04:32,800 HAS TAUGHT US ABOUT HOW WE DO 124 00:04:32,800 --> 00:04:34,600 SCIENCE, HOW DO WE CONVERT WHAT 125 00:04:34,600 --> 00:04:36,960 WE KNOW INTO WHAT WE DO, ARE 126 00:04:36,960 --> 00:04:38,640 REALLY, REALLY IMPORTANT AND 127 00:04:38,640 --> 00:04:40,560 THEY WILL IN FACT GUIDE THE 128 00:04:40,560 --> 00:04:42,520 SHAPING OF OUR FUTURE BEYOND THE 129 00:04:42,520 --> 00:04:46,040 RETURN TO WORKPLACE ISSUES THAT 130 00:04:46,040 --> 00:04:47,560 ARE STILL BEING SORTED OUT AND 131 00:04:47,560 --> 00:04:48,600 WHETHER WE LINGER ON. 132 00:04:48,600 --> 00:04:51,120 LIKE 9/11, WHERE LIFE WILL NEVER 133 00:04:51,120 --> 00:04:52,440 GO BACK WHERE WE CAN WALK 134 00:04:52,440 --> 00:04:54,320 THROUGH AN AIRPORT SECURITY WITH 135 00:04:54,320 --> 00:04:55,600 EVERYTHING ON BOARD, RIGHT. 136 00:04:55,600 --> 00:04:58,360 THAT IS LIKELY NEVER TO CHANGE. 137 00:04:58,360 --> 00:04:59,760 IT COULD BE THAT WE WOULD NEVER 138 00:04:59,760 --> 00:05:03,440 CHANGE AS A SOCIETY, GO BACK TO 139 00:05:03,440 --> 00:05:04,680 PREVIOUS-PANDEMIC TIMES, BUT WE 140 00:05:04,680 --> 00:05:11,040 MAY COME UP WITH THE HAPPY 141 00:05:11,040 --> 00:05:12,200 EQUILIBRIUM WE SEEK. 142 00:05:12,200 --> 00:05:16,320 I WANT TO FOCUS ON NIDCR AND THE 143 00:05:16,320 --> 00:05:19,240 RESEARCH FROM COVID BUT ALSO 144 00:05:19,240 --> 00:05:21,040 BRINGING NEWS TO YOU FROM OUR 145 00:05:21,040 --> 00:05:22,320 INTRAMURAL AND EXTRAMURAL 146 00:05:22,320 --> 00:05:22,760 PROGRAMS. 147 00:05:22,760 --> 00:05:24,400 WE ROTATE OUR SPEAKERS AND I 148 00:05:24,400 --> 00:05:26,480 THOUGHT THIS TIME FOCUSING ON 149 00:05:26,480 --> 00:05:29,240 OUR SUCCESS STORIES AND THEN 150 00:05:29,240 --> 00:05:32,120 WOULD BE A GOOD WAY TO 151 00:05:32,120 --> 00:05:32,480 COMMUNICATE. 152 00:05:32,480 --> 00:05:33,440 BUT EVERYTHING FOR YOU NOW IN 153 00:05:33,440 --> 00:05:37,120 THE CONTEXT OF WHERE THE REPORT 154 00:05:37,120 --> 00:05:38,680 STANDS, WHAT THE DISSEMINATION 155 00:05:38,680 --> 00:05:40,680 HAS BEEN LIKE, WHAT WE HOPE TO 156 00:05:40,680 --> 00:05:42,240 ACHIEVE IN TERMS OF ORAL HEALTH 157 00:05:42,240 --> 00:05:45,320 FOR ALL AND HOW THAT IN FACT IS 158 00:05:45,320 --> 00:05:46,720 CONNECTED TO OUR STRATEGIC PLAN 159 00:05:46,720 --> 00:05:48,320 THAT SERVES AS A ROADMAP FOR ALL 160 00:05:48,320 --> 00:05:52,440 OF US WORKING AT NIDCR AND 161 00:05:52,440 --> 00:05:53,280 BEYOND. 162 00:05:53,280 --> 00:05:55,680 MUCH FOCUS ON DEIA 163 00:05:55,680 --> 00:05:57,040 ACCESSIBILITY, BEING THE TERM 164 00:05:57,040 --> 00:05:59,000 THAT WILL DEFINE THE INCLUSION 165 00:05:59,000 --> 00:06:01,400 AND WELCOMING OF INDIVIDUALS 166 00:06:01,400 --> 00:06:05,440 WITH DISABILITIES AND LGBTQ 167 00:06:05,440 --> 00:06:07,200 COMMUNITY. 168 00:06:07,200 --> 00:06:08,480 NEW INITIATIVES AND PROGRAMS 169 00:06:08,480 --> 00:06:10,720 THAT LINK SO YOU CAN REFER TO 170 00:06:10,720 --> 00:06:12,640 THIS AFTER AS THE POWER POINTS 171 00:06:12,640 --> 00:06:13,920 ARE MADE AVAILABLE TO YOU AND 172 00:06:13,920 --> 00:06:18,280 THEN JUST CASTING A LIGHT ON 173 00:06:18,280 --> 00:06:19,920 WHAT OUR NEXT 25 YEARS WILL 174 00:06:19,920 --> 00:06:20,640 SHAPE UP TO BE. 175 00:06:20,640 --> 00:06:23,200 SO THE WORLD HAS CHANGED AND 176 00:06:23,200 --> 00:06:26,440 I'LL SAY THAT NOW IN NO 177 00:06:26,440 --> 00:06:27,240 UNCERTAIN TERMS AND WE ARE START 178 00:06:27,240 --> 00:06:30,640 OF THAT AND IT TAUGHT US AS CAN 179 00:06:30,640 --> 00:06:34,520 YOU SEE, ABOUT THE IMPORTANCE OF 180 00:06:34,520 --> 00:06:36,440 TEAMWORK, OF INTEGRATION AND 181 00:06:36,440 --> 00:06:37,240 CONNECTING THE DOTS ACROSS THE 182 00:06:37,240 --> 00:06:39,920 BOARD AND THAT IS IN FACT THE 183 00:06:39,920 --> 00:06:42,000 MESSAGE OF TODAY'S REPORT AND 184 00:06:42,000 --> 00:06:43,440 TEAM SCIENCE, TEAMWORK, COMING 185 00:06:43,440 --> 00:06:44,840 TOGETHER WITH THAT SPIRIT THAT 186 00:06:44,840 --> 00:06:49,320 WE CAN DO FARBER WHEN YOU HAVE 187 00:06:49,320 --> 00:06:54,360 COLLECTIVE DIVERSE EXPERTISE AND 188 00:06:54,360 --> 00:06:54,960 IN DETERMINES OF THE NATIONAL 189 00:06:54,960 --> 00:06:56,960 FRONTS IT'S CLEAR THAT NIH IS 190 00:06:56,960 --> 00:06:58,400 MOVING TOWARDS THE AREA OF 191 00:06:58,400 --> 00:07:02,400 TRANSLATION AND I THINK THE 192 00:07:02,400 --> 00:07:03,720 PANDEMIC'S SUCCESS STORIES 193 00:07:03,720 --> 00:07:06,320 AMPLIFY THE IMPORTANCE OF TAKING 194 00:07:06,320 --> 00:07:08,760 RISK AND INVEST NORTH HIGH-RISK 195 00:07:08,760 --> 00:07:13,040 AND HIGH REWARD AND BEING ABLE 196 00:07:13,040 --> 00:07:23,560 TO DO IT MUST FROM THE EVIDENCE 197 00:07:29,560 --> 00:07:36,760 CREATED FROM OUR SCIENTIFIC SIGE 198 00:07:36,760 --> 00:07:37,840 ENDEAVOR AND WE CAN PROVIDE THE 199 00:07:37,840 --> 00:07:39,000 EVIDENCE THAT FORMS THE BASICS 200 00:07:39,000 --> 00:07:39,560 FOR IT. 201 00:07:39,560 --> 00:07:41,560 I'M JUST GUESSING THERE ARE 10 202 00:07:41,560 --> 00:07:42,680 NEW SCHOOLS THAT HAVE OPENED UP 203 00:07:42,680 --> 00:07:44,280 IN THE LAST FEW YEARS AND MORE 204 00:07:44,280 --> 00:07:48,240 TO COME AND CHANGING THE 205 00:07:48,240 --> 00:07:50,480 LANDSCAPE AGAIN OF ACADEMIA AND 206 00:07:50,480 --> 00:07:52,720 PRESSING DEMANDS FOR DIGITAL 207 00:07:52,720 --> 00:07:55,080 TECHNOLOGY BEING SO MUCH AN 208 00:07:55,080 --> 00:07:56,920 INVESTMENT TO DENTAL SCHOOLS 209 00:07:56,920 --> 00:07:57,960 THERE ARE DECLINING LEVELS OF 210 00:07:57,960 --> 00:08:00,400 SUPPORT EVEN AMONGST THE 211 00:08:00,400 --> 00:08:01,720 RESEARCH SCHOOLS AND IF YOU WANT 212 00:08:01,720 --> 00:08:04,240 TO USE THAT TERM, THE SCHOOLS 213 00:08:04,240 --> 00:08:06,160 ARE HEAVILY INVESTED IN IT SO 214 00:08:06,160 --> 00:08:08,400 IT'S IMPORTANT FOR NIDCR TO 215 00:08:08,400 --> 00:08:09,800 MAINTAIN ITS PRESENCE IN THAT 216 00:08:09,800 --> 00:08:12,000 SECTOR AND TO BE ENGAGING OTHER 217 00:08:12,000 --> 00:08:13,040 INSTITUTIONS TO MAKE THIS IN 218 00:08:13,040 --> 00:08:16,240 FACT A COMBINED INITIATIVE, WE 219 00:08:16,240 --> 00:08:18,480 DRAW EVERYONE IN AND EXPAND THE 220 00:08:18,480 --> 00:08:20,400 WORKFORCE TO INCLUDE CLINICIANS, 221 00:08:20,400 --> 00:08:22,760 CLINICAL FACULTY AND OTHERS WHO 222 00:08:22,760 --> 00:08:24,400 IN THE PAST HAVE NOT BEEN THAT 223 00:08:24,400 --> 00:08:27,040 ENGAGE FOR ONE REASON OR THE 224 00:08:27,040 --> 00:08:29,520 OTHER AND WE HAVE VERY STRONG 225 00:08:29,520 --> 00:08:31,480 SUPPORT FOR AND I MUST 226 00:08:31,480 --> 00:08:33,720 ACKNOWLEDGE GRATEFULLY FOR THE 227 00:08:33,720 --> 00:08:41,160 EFFORTS AND ADVOCACY AND REALLY 228 00:08:41,160 --> 00:08:43,240 CREATING THE FORUM WITH GRAINY 229 00:08:43,240 --> 00:08:44,600 AND GRANTEES WHICH ARE GENERAL 230 00:08:44,600 --> 00:08:47,240 SESSIONS AND WE HAVE SEEN AN 231 00:08:47,240 --> 00:08:50,920 INCREASE IN WEBINARS WHERE WE'RE 232 00:08:50,920 --> 00:08:52,360 INVOLVED AND IT'S THE TIME OF 233 00:08:52,360 --> 00:08:53,440 NEW AGE. 234 00:08:53,440 --> 00:08:54,840 MAYBE CONSIDER THOSE FORMS OF 235 00:08:54,840 --> 00:08:56,880 COMMUNICATION AND IN ADDITION TO 236 00:08:56,880 --> 00:08:59,880 OUR TRADITION. 237 00:08:59,880 --> 00:09:01,440 JENNIFER AND I HAVE WORKED HARD 238 00:09:01,440 --> 00:09:03,480 AND WE'LL CONTINUE TO ESTABLISH 239 00:09:03,480 --> 00:09:04,800 STRONG RELATIONSHIPS WITH THE 240 00:09:04,800 --> 00:09:07,000 NATIONAL DENTAL ASSOCIATION, 241 00:09:07,000 --> 00:09:09,120 HISPANIC DENTAL ASSOCIATION AND 242 00:09:09,120 --> 00:09:12,560 THE NATIVE AMERICAN SOCIETY THAT 243 00:09:12,560 --> 00:09:14,560 ARE TOGETHER HAVE FORMED DDS. 244 00:09:14,560 --> 00:09:16,960 THE DIVERSE DENTAL SOCIETY AND 245 00:09:16,960 --> 00:09:19,000 ALONG WITH ADA THAT HAS A NEW 246 00:09:19,000 --> 00:09:21,720 LEADER IN PLACE WE MEET 247 00:09:21,720 --> 00:09:23,160 REGULARLY AND FORGING 248 00:09:23,160 --> 00:09:24,120 COLLABORATIVES AND WE'RE COMING 249 00:09:24,120 --> 00:09:26,560 TOGETHER ACROSS OUR SEEKOSIS 250 00:09:26,560 --> 00:09:28,240 TOMORROW'S BECAUSE OUR CARE AND 251 00:09:28,240 --> 00:09:30,920 OUR MISSION TO PROVIDING QUALITY 252 00:09:30,920 --> 00:09:32,480 AFFORDABLE ORAL HEALTH FOR ALL 253 00:09:32,480 --> 00:09:37,080 IS COMMON TO US AND IT TIES IT 254 00:09:37,080 --> 00:09:38,320 TOGETHER AND OF COURSE THE 255 00:09:38,320 --> 00:09:40,360 SUPPORT OF OUR EDUCATIONAL 256 00:09:40,360 --> 00:09:42,320 LEADERS TO IDEA. 257 00:09:42,320 --> 00:09:47,080 WE ARE ESTABLISHING THROUGH 258 00:09:47,080 --> 00:09:49,080 AADOCR AND OUR DIRECT CONTACT 259 00:09:49,080 --> 00:09:51,000 WITH PATIENT ADD VOW SEE GROUPS 260 00:09:51,000 --> 00:09:52,640 AS THE PORTFOLIO ACTUALLY MOVES 261 00:09:52,640 --> 00:10:00,720 TO A VERY PATIENT-CENTERED FORM. 262 00:10:00,720 --> 00:10:01,320 AND THROUGHOUT NIDCR, THE 263 00:10:01,320 --> 00:10:03,320 EFFORTS OF MATT HOFMANN AND HIS 264 00:10:03,320 --> 00:10:05,360 GROUP OF INTRAMURAL RESEARCHERS 265 00:10:05,360 --> 00:10:06,880 IS COMMENDABLE BECAUSE THERE'S 266 00:10:06,880 --> 00:10:08,760 SO MUCH TRANSLATION OCCURRING 267 00:10:08,760 --> 00:10:11,000 AND IN LABS OF PRIMARILY 268 00:10:11,000 --> 00:10:15,760 COMMITTED TO FOUNDATIONAL 269 00:10:15,760 --> 00:10:17,120 SCIENCE SOMETHING IS TICKING. 270 00:10:17,120 --> 00:10:18,760 AND YOU WILL SEE ME TALK MUCH 271 00:10:18,760 --> 00:10:20,920 MORE ABOUT OUR OFFICE OF THE 272 00:10:20,920 --> 00:10:22,960 CLINICAL DIRECTOR IN A FEW 273 00:10:22,960 --> 00:10:23,200 MINUTES. 274 00:10:23,200 --> 00:10:26,280 VERY WARM WELCOME TO TWO 275 00:10:26,280 --> 00:10:33,080 LONGSTANDING COLLEAGUES, LOUIESA 276 00:10:33,080 --> 00:10:35,960 IS A LEADER IN THE FIELD AT 277 00:10:35,960 --> 00:10:37,240 HIGHER UNIVERSITY LEVELS AND HAS 278 00:10:37,240 --> 00:10:38,880 SERVED ON STUDY SECTIONS, 279 00:10:38,880 --> 00:10:40,440 SOMEONE I KNOW FOR MANY YEARS 280 00:10:40,440 --> 00:10:42,320 AND WILL LEND US A LOT OF WISDOM 281 00:10:42,320 --> 00:10:44,560 IN HER TIME. 282 00:10:44,560 --> 00:10:47,760 ESPECIALLY THRILLED TO HAVE 283 00:10:47,760 --> 00:10:48,720 TERRY DICK INSON. 284 00:10:48,720 --> 00:10:50,240 IT'S IMPORTANT TO BE 285 00:10:50,240 --> 00:10:51,120 REPRESENTATIVE OF THE NEEDS OF 286 00:10:51,120 --> 00:10:51,760 THE COMMUNITY. 287 00:10:51,760 --> 00:10:53,640 YOU'VE BEEN RECOGNIZED BY ADA 288 00:10:53,640 --> 00:10:55,160 FOR DISTINGUISHING SERVICE TO 289 00:10:55,160 --> 00:10:57,600 OUR PROFESSION AND YOU COME IN 290 00:10:57,600 --> 00:11:00,440 AS AN EXPERIENCED CLINICIAN, 291 00:11:00,440 --> 00:11:03,200 LEGISLATE OR HEADING STATE 292 00:11:03,200 --> 00:11:04,560 DENTAL ORGANIZATIONS, ET CETERA. 293 00:11:04,560 --> 00:11:06,400 YOU WERE MY MENTOR IN DENTAL 294 00:11:06,400 --> 00:11:06,640 SCHOOL. 295 00:11:06,640 --> 00:11:08,240 YOU WERE MY PRIVATE SECTOR 296 00:11:08,240 --> 00:11:09,680 MENTOR AND I'LL NEVER FORGET 297 00:11:09,680 --> 00:11:17,320 THAT INFLUENCE YOU HAD ON ME. 298 00:11:17,320 --> 00:11:19,960 I THOUGHT YOUR COMMUNICATION 299 00:11:19,960 --> 00:11:20,920 WITH OUR TEAM IN COUNCIL WOULD 300 00:11:20,920 --> 00:11:23,760 HELP US SHAPE INITIATIVES AND 301 00:11:23,760 --> 00:11:25,080 OPPORTUNITIES SO THAT WE CAN 302 00:11:25,080 --> 00:11:26,760 DRAW IN THAT COMMUNITY AND MAKE 303 00:11:26,760 --> 00:11:29,240 SURE THAT THEY ARE BEING GIVEN 304 00:11:29,240 --> 00:11:33,360 COMPASSIONATE CARE -- SPECIAL 305 00:11:33,360 --> 00:11:33,600 NEEDS. 306 00:11:33,600 --> 00:11:41,640 THRILLED TO HAVE BRINGS 307 00:11:41,640 --> 00:11:43,360 ENTHUSIASM, MATURITY AND WISDOM 308 00:11:43,360 --> 00:11:45,960 TO THIS VERY COMPLEX OFFICE THAT 309 00:11:45,960 --> 00:11:48,080 DEALS WITH COMMUNICATIONS AND 310 00:11:48,080 --> 00:11:49,920 EVER WHICH WAY AND HEALTH 311 00:11:49,920 --> 00:11:51,560 EDUCATION SO WHERE YOU SEE 312 00:11:51,560 --> 00:11:53,920 DEVELOPMENT IS IN THE OUTREACH 313 00:11:53,920 --> 00:11:57,160 ASPECT OF THE OFFICE SO WELCOME 314 00:11:57,160 --> 00:11:58,040 ALICIA AND WE'RE THRILLED TO 315 00:11:58,040 --> 00:12:00,120 HAVE YOU ON BOARD ALONG WITH TWO 316 00:12:00,120 --> 00:12:01,040 IMPORTANT INDIVIDUALS WHO WILL 317 00:12:01,040 --> 00:12:02,360 JOIN THE OFFICE OF SCIENCE, 318 00:12:02,360 --> 00:12:05,200 POLICY AND ANALYSIS. 319 00:12:05,200 --> 00:12:07,360 COMING BACK TO NIDCR, IS GOING 320 00:12:07,360 --> 00:12:08,960 TO HEAD ONE DIVISION AND SHE'S 321 00:12:08,960 --> 00:12:11,840 GOING TO BE CHIEF OF THE SCIENCE 322 00:12:11,840 --> 00:12:15,760 POLICY DIVISION AND MARUSHKA, 323 00:12:15,760 --> 00:12:18,600 ONE OF OUR PAST TRAINEES WHO 324 00:12:18,600 --> 00:12:21,160 COMES FROM GREAT EXPERTISE FROM 325 00:12:21,160 --> 00:12:23,120 NIAID WHERE SHE HEADED OFF 326 00:12:23,120 --> 00:12:24,440 TOBACCO CESSATION PROGRAM SO WE 327 00:12:24,440 --> 00:12:26,200 HAVE TWO VERY OUTSTANDING 328 00:12:26,200 --> 00:12:29,600 INDIVIDUALS WHO WILL HELP SHAPE 329 00:12:29,600 --> 00:12:30,920 OSPA IN THE NEAR FUTURE. 330 00:12:30,920 --> 00:12:34,360 A VERY GRATEFUL TO LESLEY 331 00:12:34,360 --> 00:12:34,760 FREEDON. 332 00:12:34,760 --> 00:12:38,000 MANY HAVE INTERACTED WITH HER, 333 00:12:38,000 --> 00:12:40,560 TRAINING ESPECIALLY HAVE 334 00:12:40,560 --> 00:12:42,200 BENEFITED FROM HER INDIVIDUAL 335 00:12:42,200 --> 00:12:43,720 GUIDANCE AND CARE FOR YOUR 336 00:12:43,720 --> 00:12:45,120 CAREER DEVELOPMENT. 337 00:12:45,120 --> 00:12:47,480 SHE IS MOVING ON TO A VERY 338 00:12:47,480 --> 00:12:49,040 IMPORTANT POSITION AT GEORGE 339 00:12:49,040 --> 00:12:51,200 MAYSON AND HAS DONE ALL THESE 340 00:12:51,200 --> 00:12:52,480 THINGS YOU SEE ON THE RIGHT. 341 00:12:52,480 --> 00:12:55,200 THANK YOU, LESLEY, FOR YOUR 342 00:12:55,200 --> 00:12:59,480 SERVICE WE WISH YOU ALL AND AS I 343 00:12:59,480 --> 00:13:00,640 ALWAYS SAY FOR NIDCR, WE'LL SEE 344 00:13:00,640 --> 00:13:02,360 YOU BACK, HOPEFULLY. 345 00:13:02,360 --> 00:13:04,280 SO WHAT IS NIH STAND TOGETHER? 346 00:13:04,280 --> 00:13:06,600 WE REMAIN A VERY ROBUST 347 00:13:06,600 --> 00:13:08,160 ORGANIZATION WITH BLESSED WITH 348 00:13:08,160 --> 00:13:11,120 SUPPORT FROM CONGRESS AND 349 00:13:11,120 --> 00:13:16,000 FUNDING THAT WAS ABLE TO I THINK 350 00:13:16,000 --> 00:13:16,840 MAKE A HUGE STRIDES DURING COVID 351 00:13:16,840 --> 00:13:18,160 THAT CONTINUES ON PREPARING FOR 352 00:13:18,160 --> 00:13:20,040 THE NEXT PANDEMIC AND HAVING 353 00:13:20,040 --> 00:13:21,840 PLATFORMS OF AVAILABILITY, BOTH 354 00:13:21,840 --> 00:13:24,160 IN THE COMMUNITY AND WITH LABS 355 00:13:24,160 --> 00:13:26,360 AT NIH AND IN ADDITION TO 356 00:13:26,360 --> 00:13:28,360 TRAINING AND COMMUNICATION, WE 357 00:13:28,360 --> 00:13:34,000 ALSO ARE PROUD TO HAVE SEVERAL 358 00:13:34,000 --> 00:13:36,680 NOBLE LAUREATES IN OUR MIDST. 359 00:13:36,680 --> 00:13:38,360 THE SEVEN CENTERS THAT HAVE NO 360 00:13:38,360 --> 00:13:40,000 FUNDING AUTHORITY ACTUALLY ARE 361 00:13:40,000 --> 00:13:42,600 COMING TOGETHER IN A VERY NICE 362 00:13:42,600 --> 00:13:42,960 WAY. 363 00:13:42,960 --> 00:13:47,800 I STRESSED BEFORE, NIDCR AND 364 00:13:47,800 --> 00:13:50,280 NINR THE TWO INSTITUTES THAT ARE 365 00:13:50,280 --> 00:13:51,840 ACTUALLY RESPONSIBLE FOR 366 00:13:51,840 --> 00:14:02,480 SHEPHERDING A PROFESSION OF CANY 367 00:14:04,200 --> 00:14:07,040 ENOUGH ABOUT LARRY TABAK WHO IS 368 00:14:07,040 --> 00:14:09,120 A DDS AS YOU KNOW AND LEADING 369 00:14:09,120 --> 00:14:11,120 NIH TODAY AND WILL CONTINUE TO 370 00:14:11,120 --> 00:14:14,960 DO SO BASED ON HIS COMMUNICATION 371 00:14:14,960 --> 00:14:16,920 AND HE WOULD LIKELY DAY IN THAT 372 00:14:16,920 --> 00:14:18,320 POSITION THROUGH THE END OF THE 373 00:14:18,320 --> 00:14:22,240 YEAR AND THROUGH THE SPRING OF 374 00:14:22,240 --> 00:14:26,800 NEXT YEAR. 375 00:14:26,800 --> 00:14:28,560 LARRY IS DOING AN AMAZING JOB. 376 00:14:28,560 --> 00:14:32,440 HE IS JUST AMAZING. 377 00:14:32,440 --> 00:14:34,800 THE NEXT HIRE IS THE FIRST WOMAN 378 00:14:34,800 --> 00:14:36,200 DIRECTOR OF THE NATIONAL CANCER 379 00:14:36,200 --> 00:14:37,640 INSTITUTE WHO COMES IN FROM 380 00:14:37,640 --> 00:14:43,440 HARVARD MEDICAL, BRIGHAM WOMEN'S 381 00:14:43,440 --> 00:14:45,360 HOSPITAL, SHE'S A CANCER 382 00:14:45,360 --> 00:14:47,720 SURGEON, ONCOLOGIST SURGEON AND 383 00:14:47,720 --> 00:14:51,200 HAS DONE WORK IN THE AREA OF 384 00:14:51,200 --> 00:14:52,800 G.I. ONCOLOGY AND WE'RE HAPPY TO 385 00:14:52,800 --> 00:14:55,040 HAVE MONICA ON BOARD. 386 00:14:55,040 --> 00:14:56,480 PRESIDENT JOE BIDEN HAS CAST OUR 387 00:14:56,480 --> 00:15:00,680 IMPERATIVES FOR US. 388 00:15:00,680 --> 00:15:07,280 HIS PRIORITIES ARE, FUNDING 389 00:15:07,280 --> 00:15:08,840 CONDITIONS THAT ARISE DUE TO SO 390 00:15:08,840 --> 00:15:11,840 MANY VIRUSES AND THREATS THAT IT 391 00:15:11,840 --> 00:15:13,720 IS IMPORTANT FOR US TO CONTINUE 392 00:15:13,720 --> 00:15:17,440 THIS JOURNEY AND SO THERE'S AN 393 00:15:17,440 --> 00:15:19,560 EMPHASIS ACROSS OUR CAMPUS ON 394 00:15:19,560 --> 00:15:19,800 CANCER. 395 00:15:19,800 --> 00:15:21,800 YOU CAN SEE FROM THE PAIN 396 00:15:21,800 --> 00:15:24,040 MANAGEMENT AND SUBSTANCE USE 397 00:15:24,040 --> 00:15:25,480 DISORDER CRISIS THAT WE FACE 398 00:15:25,480 --> 00:15:28,640 THAT THIS HAS TO BE A NATIONAL 399 00:15:28,640 --> 00:15:29,840 PUBLIC-HEALTH ISSUE, A 400 00:15:29,840 --> 00:15:31,440 PUBLIC-HEALTH ISSUE FOR OUR 401 00:15:31,440 --> 00:15:32,760 NATION AND THERE WAS A LOT OF 402 00:15:32,760 --> 00:15:35,000 FOCUS ON COMING UP AT 403 00:15:35,000 --> 00:15:38,600 REPLACEMENTS FOR OPIOIDS, 404 00:15:38,600 --> 00:15:42,320 MINIMIZING THE PRESCRIPTION, 405 00:15:42,320 --> 00:15:48,320 LOOKING AT DIFFERENT WAYS TO 406 00:15:48,320 --> 00:15:50,440 HANDLE CENTRAL VERSUS PERIPHERAL 407 00:15:50,440 --> 00:15:53,880 PAIN MECHANISMS AND THIS IS 408 00:15:53,880 --> 00:15:55,400 CLEARLY APPEARING AS ONE OF THE 409 00:15:55,400 --> 00:15:58,040 SAD ASPECTS OF THE PANDEMIC. 410 00:15:58,040 --> 00:16:00,440 THE RATES OF OPIOID RELATED 411 00:16:00,440 --> 00:16:03,800 SUICIDES, THE RATES OF FENTANYL 412 00:16:03,800 --> 00:16:04,720 CONTAMINATION AND IN DRUGS THAT 413 00:16:04,720 --> 00:16:07,200 ARE USED INCLUDING OPIOIDS IS 414 00:16:07,200 --> 00:16:11,080 JUST SICKENING ALARMING. 415 00:16:11,080 --> 00:16:13,320 WE ARE WORKING WITH NORAH WHO 416 00:16:13,320 --> 00:16:15,080 CAME TO US FROM THE NATIONAL 417 00:16:15,080 --> 00:16:18,880 INSTITUTE OF DENTAL DRUG ABUSE 418 00:16:18,880 --> 00:16:21,440 TO ASK IF WE WOULD COLLABORATE 419 00:16:21,440 --> 00:16:23,280 ON LOOKING AT THE ROLE OF ORAL 420 00:16:23,280 --> 00:16:25,560 HEALTH PROFESSIONALS AND 421 00:16:25,560 --> 00:16:27,760 DETECTING AND REFERRING 422 00:16:27,760 --> 00:16:29,800 TEENAGERS AND YOUNG ADOLESCENTS 423 00:16:29,800 --> 00:16:32,240 THAT ARE SUCK COMING TO THE 424 00:16:32,240 --> 00:16:34,600 STRAIN SO WE CAN COME UP WITH AN 425 00:16:34,600 --> 00:16:38,480 INTERVENTION EFFECTIVE FOR THIS 426 00:16:38,480 --> 00:16:38,920 NATION. 427 00:16:38,920 --> 00:16:40,400 IT'S INTERESTING THAT WE STAND 428 00:16:40,400 --> 00:16:42,640 AS ONE OF THE MOST DEVELOPED 429 00:16:42,640 --> 00:16:46,480 COUNTRIES BUT ALSO HAVE IS THE 430 00:16:46,480 --> 00:16:47,720 WORST STATISTICS WHEN IT COMES 431 00:16:47,720 --> 00:16:52,680 TO LOOKING AT MORBIDITY AND 432 00:16:52,680 --> 00:16:54,320 MORTALITY AND THIS IS SURPRISING 433 00:16:54,320 --> 00:16:56,080 ME WE WOULD RANK UP HIGH THERE. 434 00:16:56,080 --> 00:16:59,080 FOR THAT REASON, THE GOVERNMENT 435 00:16:59,080 --> 00:17:02,080 AS WELL AS NIH HAS PRIORITIZED A 436 00:17:02,080 --> 00:17:03,520 NATIONAL COHORT THAT IS ACTUALLY 437 00:17:03,520 --> 00:17:05,000 GOING TO BE INTERNATIONAL, 438 00:17:05,000 --> 00:17:07,760 LOOKING AT MATERNAL HEALTH 439 00:17:07,760 --> 00:17:09,800 ACTION AND ALL ACROSS HERE, WE 440 00:17:09,800 --> 00:17:10,880 HAVE MANY CONDITIONS WHETHER 441 00:17:10,880 --> 00:17:16,160 IT'S PREGNANCY AND NUTRITION, 442 00:17:16,160 --> 00:17:17,240 FLOOR I HAD, CRANIOFACIAL 443 00:17:17,240 --> 00:17:18,840 ANOMALIES AND NIDCR WILL PLAY A 444 00:17:18,840 --> 00:17:21,480 ROLE IN MATERNAL HEALTH ACTION 445 00:17:21,480 --> 00:17:25,280 AND ALSO PRE-NATAL AND EARLY 446 00:17:25,280 --> 00:17:25,960 PERINATAL HEALTH. 447 00:17:25,960 --> 00:17:27,760 MOST OF YOU HAVE HEARD OF THIS 448 00:17:27,760 --> 00:17:28,280 PROGRAM. 449 00:17:28,280 --> 00:17:30,240 THE FRANCIS COLLINS INITIATED IT 450 00:17:30,240 --> 00:17:32,320 WAS ONE OF HIS FLAGSHIP 451 00:17:32,320 --> 00:17:32,800 INITIATIVES. 452 00:17:32,800 --> 00:17:34,400 DRAWING ABOUT A MILLION PATIENTS 453 00:17:34,400 --> 00:17:37,360 INTO A REPOSITORY INTO A COHORT 454 00:17:37,360 --> 00:17:39,480 CALLED "ALL OF US" AND IT WOULD 455 00:17:39,480 --> 00:17:41,600 INVOLVE FOR THE FIRST TIME 456 00:17:41,600 --> 00:17:43,080 COLLECTING GENOMES AND LOOKING 457 00:17:43,080 --> 00:17:45,440 AT A MULTI-PRONGED APPROACH TO 458 00:17:45,440 --> 00:17:46,880 LOOKING AT WHAT IS HEALTH AND 459 00:17:46,880 --> 00:17:48,760 WHAT IS DISEASE. 460 00:17:48,760 --> 00:17:50,800 VERY POPULATION-SPECIFIC AND 461 00:17:50,800 --> 00:17:52,040 VERY ATTRACTIVE TO US BECAUSE 462 00:17:52,040 --> 00:17:54,400 FOR THE FIRST TIME, WE HAVE A 463 00:17:54,400 --> 00:18:00,080 DIVERSE ARRAY OF DATA TO DRAW 464 00:18:00,080 --> 00:18:00,280 FROM. 465 00:18:00,280 --> 00:18:02,960 NIDCR HAS MANAGED SO THE HELP OF 466 00:18:02,960 --> 00:18:04,800 LILLIAN AND JENNIFER AND I TO 467 00:18:04,800 --> 00:18:06,680 ACTUALLY CREATE A QUESTIONNAIRE 468 00:18:06,680 --> 00:18:08,000 TO INCLUDE QUESTIONS IN THE 469 00:18:08,000 --> 00:18:11,560 HISTORY TAKING THAT WE CAN MINE 470 00:18:11,560 --> 00:18:12,240 FURTHER ON. 471 00:18:12,240 --> 00:18:14,840 THERE ARE PROJECTS THAT ARE 472 00:18:14,840 --> 00:18:16,040 FUNDED THROUGH THE PROGRAM AND 473 00:18:16,040 --> 00:18:20,720 YOU CAN SEE THEM, THEY DEAL WITH 474 00:18:20,720 --> 00:18:24,440 AGE-RELATED OR LIFESPAN RELATED 475 00:18:24,440 --> 00:18:25,360 CONDITIONS, CLEFT PALATE AND 476 00:18:25,360 --> 00:18:28,720 LOOKING AT OUR ELECTRONIC HEALTH 477 00:18:28,720 --> 00:18:30,600 RECORDS AND FROM THE BIG MOUTH 478 00:18:30,600 --> 00:18:33,200 DENTAL DATA REPOSITORY TO 479 00:18:33,200 --> 00:18:34,840 UNDERSTAND HOW ETHNIC 480 00:18:34,840 --> 00:18:37,120 BACKGROUNDS, BEHAVIOR, SOCIAL 481 00:18:37,120 --> 00:18:38,160 ECONOMICS INFLUENCE HEALTH SO 482 00:18:38,160 --> 00:18:39,240 THERE'S A LOT MORE HERE 483 00:18:39,240 --> 00:18:40,280 AVAILABLE TO THE COMMUNITY. 484 00:18:40,280 --> 00:18:42,680 I URGE YOU ALL TO TAKE A LOOK AT 485 00:18:42,680 --> 00:18:43,000 IT. 486 00:18:43,000 --> 00:18:45,880 I BRING THIS UP BECAUSE I THINK 487 00:18:45,880 --> 00:18:47,200 IT SHAPES FOR NIDCR, A VISION 488 00:18:47,200 --> 00:18:50,160 FOR THE FUTURE IN TERMS OF OUR 489 00:18:50,160 --> 00:18:56,240 GLOBAL HEALTH RESEARCH 490 00:18:56,240 --> 00:18:56,520 INITIATIVES. 491 00:18:56,520 --> 00:18:58,320 WE ARE REVITALIZING THE PRESENCE 492 00:18:58,320 --> 00:19:00,840 AND IT'S INTERESTING HOW BILL 493 00:19:00,840 --> 00:19:03,040 AND MELINDA GATES FOUNDATION 494 00:19:03,040 --> 00:19:05,120 INITIATIVE TOOK A HOLISTIC 495 00:19:05,120 --> 00:19:06,520 STANCE ON GLOBAL HEALTH THAN 496 00:19:06,520 --> 00:19:09,480 EVER BEFORE AND SO THEY FOCUS ON 497 00:19:09,480 --> 00:19:11,000 TWO DISEASES THAT ARE PREVALENT 498 00:19:11,000 --> 00:19:14,000 IN AFRICA, HIV AND SICKLE CELL 499 00:19:14,000 --> 00:19:14,240 DISEASE. 500 00:19:14,240 --> 00:19:21,000 YOU CAN SEE FROM THESE OUTLINES 501 00:19:21,000 --> 00:19:23,480 IT'S INVOLVING OMICS IN MANY 502 00:19:23,480 --> 00:19:25,120 WAYS AND IT'S A COMBINATION OF 503 00:19:25,120 --> 00:19:27,720 LOOKING AT THE WHETHER THE 504 00:19:27,720 --> 00:19:29,120 INFRASTRUCTURE IS IN PLACE FOR 505 00:19:29,120 --> 00:19:31,200 SUSTAINABILITY AND ROBUSTNESS OF 506 00:19:31,200 --> 00:19:33,680 HEALTHCARE AND TO BE LOOKING AT 507 00:19:33,680 --> 00:19:35,240 REGIONAL REPOSITORIES ALONG WITH 508 00:19:35,240 --> 00:19:37,720 LOOKING AT GENOTYPE, PHENOTYPE 509 00:19:37,720 --> 00:19:39,920 CORRELATIONS AND THAT TO ME IS 510 00:19:39,920 --> 00:19:44,480 PROBABLY THE FIRST TIME THAT NIH 511 00:19:44,480 --> 00:19:45,920 HAS ENGAGE IN SOMETHING WITH THE 512 00:19:45,920 --> 00:19:47,360 BILL GATES, BECAUSE WE ARE 513 00:19:47,360 --> 00:19:48,680 INVOLVED WITH THAT THAT. IS IN 514 00:19:48,680 --> 00:19:50,400 FACT KEEPING THE PATIENT IN THE 515 00:19:50,400 --> 00:19:57,360 CENTER AND TRANSLATING TO 516 00:19:57,360 --> 00:19:59,360 COMMUNITIES OF RISK AND IN NEED. 517 00:19:59,360 --> 00:20:01,000 WHEN WE THINK WE COULD BE DOING 518 00:20:01,000 --> 00:20:02,640 FOR ORAL HEALTH GLOBALLY AND 519 00:20:02,640 --> 00:20:06,840 THERE ARE A LOT OF NEEDS THERE. 520 00:20:06,840 --> 00:20:08,960 I MENTIONED THE IMPORTANCE OF 521 00:20:08,960 --> 00:20:09,840 HUMAN CONNECTIONS. 522 00:20:09,840 --> 00:20:11,440 IT STRIKES ME NOW IN ADDITION TO 523 00:20:11,440 --> 00:20:13,120 THIS FORUM, WHERE WE CAN ONLY 524 00:20:13,120 --> 00:20:17,280 ACCESS A FEW PEOPLE, BY JUST A 525 00:20:17,280 --> 00:20:18,960 SKIMMING THE SURFACE SO TO 526 00:20:18,960 --> 00:20:19,480 SPEAK. 527 00:20:19,480 --> 00:20:21,360 I URGE ALL COMMUNITIES THAT IN 528 00:20:21,360 --> 00:20:23,960 ADDITION TO THE FORMAL SESSIONS, 529 00:20:23,960 --> 00:20:27,040 WHETHER IT'S LOOKING AT SPECIFIC 530 00:20:27,040 --> 00:20:28,680 MEETINGS THAT YOU HAVE THAT YOU 531 00:20:28,680 --> 00:20:31,640 CAN CONTINUE COMMUNICATION AND 532 00:20:31,640 --> 00:20:33,200 ENCOURAGING IT WITHIN OUR 533 00:20:33,200 --> 00:20:34,960 TRAINEES AS WELL AND THEY CAN 534 00:20:34,960 --> 00:20:35,480 FORM THESE FORM I AM SORRY 535 00:20:35,480 --> 00:20:43,280 THROFORUMS WHERE THERE'SSUCCESSE 536 00:20:43,280 --> 00:20:43,960 BEST PRACTICES. 537 00:20:43,960 --> 00:20:45,600 I THINK THAT LESSON HAS COME 538 00:20:45,600 --> 00:20:50,000 THROUGH CLEARLY TO ME AND ALL OF 539 00:20:50,000 --> 00:20:51,360 THIS PLACE OUT IN THE NEXT FEW 540 00:20:51,360 --> 00:20:53,360 SLIDES AS WE LOOKED AT 541 00:20:53,360 --> 00:20:54,920 PARTNERSHIPS, TEAMWORK, 542 00:20:54,920 --> 00:20:56,440 INNOVATION, THE NEED FOR 543 00:20:56,440 --> 00:20:59,400 BUILDING OF INFRASTRUCTURE WHERE 544 00:20:59,400 --> 00:21:01,840 NEEDED AND SHARK TANK 545 00:21:01,840 --> 00:21:03,400 APPROACHES, HEALTH INEQUITIES, 546 00:21:03,400 --> 00:21:05,640 REMAINING A HUGE CONCERN FOR US 547 00:21:05,640 --> 00:21:06,760 IN ORAL HEALTH. 548 00:21:06,760 --> 00:21:08,640 THE SUCCESS STORIES AND THE USE 549 00:21:08,640 --> 00:21:12,880 OF TELE DENTISTRY IN AREAS LIKE 550 00:21:12,880 --> 00:21:14,880 ROCHESTER AND BLAZING THE TRAIL 551 00:21:14,880 --> 00:21:16,400 THERE, HAS BEEN HUGELY 552 00:21:16,400 --> 00:21:17,720 SUCCESSFUL AND OPEN FOR THE 553 00:21:17,720 --> 00:21:19,280 FURTHER DEVELOPMENT OF THE 554 00:21:19,280 --> 00:21:21,160 FUTURE AS WE USE DATA SCIENCE 555 00:21:21,160 --> 00:21:23,880 AND DEVELOP THE ALGORITHMS BASED 556 00:21:23,880 --> 00:21:27,720 ON ARTIFICIAL INTELLIGENCE AND 557 00:21:27,720 --> 00:21:28,960 MACHINE LEANING TOOLS THAT WE 558 00:21:28,960 --> 00:21:30,800 HAVE GAINED AND SIGNS AND 559 00:21:30,800 --> 00:21:32,400 TECHNOLOGIES AND LEADERSHIP 560 00:21:32,400 --> 00:21:33,720 MATTERS OF COURSE IS OBVIOUS. 561 00:21:33,720 --> 00:21:35,800 SO WHAT CAME OUT OF THIS 562 00:21:35,800 --> 00:21:37,080 BLESSINGS, DESPITE THE SAD 563 00:21:37,080 --> 00:21:39,640 TRAGEDY OF LOSS OF LIVES, WE 564 00:21:39,640 --> 00:21:41,120 HAVE NOW A PROTOCOL IN PLACE 565 00:21:41,120 --> 00:21:45,040 WITH A U.S. PANEL FOR THE FIRST 566 00:21:45,040 --> 00:21:46,680 TIME BUILT TOGETHER SEPARATE 567 00:21:46,680 --> 00:21:48,080 AGENCIES TO THE TABLE TALKING 568 00:21:48,080 --> 00:21:49,360 DIFFERENT LANGUAGES BUT 569 00:21:49,360 --> 00:21:50,680 UNDERSTANDING THE COMMON THEME 570 00:21:50,680 --> 00:21:52,800 TO COME UP WITH WHAT DO WE DO IF 571 00:21:52,800 --> 00:21:55,880 WE HAVE ANOTHER THREATENING 572 00:21:55,880 --> 00:21:57,560 PATHOGEN, WHATEVER IT MIGHT BE. 573 00:21:57,560 --> 00:21:59,960 IT COULD BE BIO TERRORISM OR A 574 00:21:59,960 --> 00:22:00,840 NEW PATHOGEN. 575 00:22:00,840 --> 00:22:01,880 WE HAVE THE PLATFORMS IN PLACE 576 00:22:01,880 --> 00:22:05,200 TO ASSESS THE PATHOGENICITY AND 577 00:22:05,200 --> 00:22:10,840 PLATFORM IN PLACE TO CREATE A 578 00:22:10,840 --> 00:22:12,640 VACCINE, ALL OF THAT NOW IS IN 579 00:22:12,640 --> 00:22:14,840 PLACE AND THAT'S GOOD. 580 00:22:14,840 --> 00:22:16,640 IT ALSO ACCOMPANIES THE WORLD 581 00:22:16,640 --> 00:22:18,360 HEALTH ORGANIZATION REPORT FOR 582 00:22:18,360 --> 00:22:23,240 THE GLOBAL COMMUNITY. 583 00:22:23,240 --> 00:22:24,880 RECOVER IS A IMPORTANT PROGRAM. 584 00:22:24,880 --> 00:22:26,280 PAY ATTENTION BECAUSE IT'S A 585 00:22:26,280 --> 00:22:29,840 REGISTRY OF THOSE WHO SUFFER THE 586 00:22:29,840 --> 00:22:33,160 LONG-TERM EFFECTS OF COVID. 587 00:22:33,160 --> 00:22:38,400 WE HEAR REMARKS AND EXPERIENCES 588 00:22:38,400 --> 00:22:40,040 FROM INDIVIDUALS THAT SUFFER AND 589 00:22:40,040 --> 00:22:42,040 IT'S TELL YOU WILL TERES AND THE 590 00:22:42,040 --> 00:22:46,400 LOSS OF TASTE ASSISTING AND 591 00:22:46,400 --> 00:22:48,520 PROBABLY DUE TO STRESS BUT WE 592 00:22:48,520 --> 00:22:49,800 DON'T HAVE THE DATA IN PLACE SO 593 00:22:49,800 --> 00:22:52,080 IF YOU HAVE PATIENTS THEY CAN 594 00:22:52,080 --> 00:22:54,800 REGISTER AND THEY'RE SYMPTOMS 595 00:22:54,800 --> 00:22:57,640 AND THEY BECOME PART OF THE 596 00:22:57,640 --> 00:22:58,920 STUDY AND THEY HAVE HUBS, THAT'S 597 00:22:58,920 --> 00:23:01,080 THE HUB ACTUALLY THE SPOKES ARE 598 00:23:01,080 --> 00:23:03,120 ALL OVER THE COUNTRY AND IT'S 599 00:23:03,120 --> 00:23:05,320 AVAILABLE ON-LINE. 600 00:23:05,320 --> 00:23:07,200 I'VE THOUGHT OF THIS AS BEING A 601 00:23:07,200 --> 00:23:08,640 WONDERFUL TOOL, REALIZING BY 602 00:23:08,640 --> 00:23:10,680 BOTH FRANCIS COLLINS AND CONNIE 603 00:23:10,680 --> 00:23:14,000 FAUCI THAT WE REALLY DIDN'T HAVE 604 00:23:14,000 --> 00:23:14,920 SCIENCE COMMUNICATION DEVELOP TO 605 00:23:14,920 --> 00:23:21,080 THE EXTENT WE HOPED FOR AND 606 00:23:21,080 --> 00:23:22,640 NIH'S COMMITMENT WAS MADE 607 00:23:22,640 --> 00:23:25,280 EVIDENT BY THIS INITIATIVE WHERE 608 00:23:25,280 --> 00:23:26,440 THE INFRASTRUCTURE IS BEING 609 00:23:26,440 --> 00:23:30,520 BUILT RIGHT NOW FOR THE 610 00:23:30,520 --> 00:23:37,040 ALLIANCES AND READY WHETHER THEY 611 00:23:37,040 --> 00:23:48,000 COME FROM OCCUR OCC -- SHOULD WS 612 00:23:48,000 --> 00:23:49,800 WE CAN INCORPORATORRAL HEALTH 613 00:23:49,800 --> 00:23:52,760 EDUCATION AND LITERACY INTO THIS 614 00:23:52,760 --> 00:23:53,960 WONDERFUL NETWORK THAT I HOPE 615 00:23:53,960 --> 00:23:55,640 WILL SPREAD TO THE REST OF THE 616 00:23:55,640 --> 00:23:56,080 COUNTRY. 617 00:23:56,080 --> 00:23:57,200 SO THAT WOULD BE WHY I THINK 618 00:23:57,200 --> 00:23:59,240 IT'S A BLESSING. 619 00:23:59,240 --> 00:24:00,520 SO WHAT DID WE DO? 620 00:24:00,520 --> 00:24:03,520 WHAT CAME OUT OF OUR DENTAL 621 00:24:03,520 --> 00:24:05,760 PRACTICE-BASED RESEARCH NETWORK? 622 00:24:05,760 --> 00:24:11,960 WE FUNDED THESE STUDIES WITH 623 00:24:11,960 --> 00:24:13,160 GREAT -- IT WAS EFFICIENTLY 624 00:24:13,160 --> 00:24:13,440 CONDUCTED. 625 00:24:13,440 --> 00:24:15,400 THANK YOU TO OUR DIVISION OF 626 00:24:15,400 --> 00:24:17,640 RESEARCH AND WE WERE NOT BIASED 627 00:24:17,640 --> 00:24:18,600 IN OUR APPROACH. 628 00:24:18,600 --> 00:24:21,800 LOOKING AT CLINICAL CONDITIONS, 629 00:24:21,800 --> 00:24:23,360 PATIENTS-CENTERED, WE LOOKED AT 630 00:24:23,360 --> 00:24:24,600 VACCINE ACCEPTABILITY AND 631 00:24:24,600 --> 00:24:24,840 READINESS. 632 00:24:24,840 --> 00:24:27,240 I HAVE A SLIDE ON THAT AND 633 00:24:27,240 --> 00:24:29,440 VARIETY OF VERY CLINICALLY 634 00:24:29,440 --> 00:24:31,640 RELEVANT QUESTIONS THAT OUR 635 00:24:31,640 --> 00:24:34,920 PROFESSION WAS CHALLENGED WITH. 636 00:24:34,920 --> 00:24:36,840 THERE'S A NEW MASS THAT'S 637 00:24:36,840 --> 00:24:38,320 DEVELOPED, IT MAY NOT BE USED 638 00:24:38,320 --> 00:24:39,960 FOR COVID BUT OTHER PATHOGENS 639 00:24:39,960 --> 00:24:42,240 COME OUR WAY AND IT DETECTS 640 00:24:42,240 --> 00:24:43,400 THROUGH PRO TEE ACES IF YOU 641 00:24:43,400 --> 00:24:44,600 ACTUALLY ARE BREATHING THROUGH 642 00:24:44,600 --> 00:24:47,840 YOUR MOUTH AND THESE ENZYMES GET 643 00:24:47,840 --> 00:24:48,960 DEPOSITED AND IT CHANGES THE 644 00:24:48,960 --> 00:24:50,960 COLOR OF AN INDICATER THAT IS 645 00:24:50,960 --> 00:24:52,400 AVAILABLE ON THE MASK SO THAT 646 00:24:52,400 --> 00:24:54,800 AND YOU CAN SEE IT'S BEEN 647 00:24:54,800 --> 00:24:56,200 PUBLISHED AND I WANT TO THANK 648 00:24:56,200 --> 00:24:57,760 THESE INVESTIGATORS COMING UP 649 00:24:57,760 --> 00:24:59,280 WITH THESE STUDIES AND REALLY 650 00:24:59,280 --> 00:25:03,080 DOING THEM IN A VERY STRATEGIC 651 00:25:03,080 --> 00:25:03,440 WAY. 652 00:25:03,440 --> 00:25:11,160 THIS WAS LED BY (INAUDIBLE) 653 00:25:11,160 --> 00:25:12,960 RUTGERS HAS LOOKED AT LONG-TERM 654 00:25:12,960 --> 00:25:14,720 COVID IN CHILDREN AND ASSESS 655 00:25:14,720 --> 00:25:17,280 WHETHER DENTISTS AND WHETHER 656 00:25:17,280 --> 00:25:18,840 THEIR ATTITUDES TESTING AND RISK 657 00:25:18,840 --> 00:25:21,360 MITIGATION AND YOU CAN SEE THAT 658 00:25:21,360 --> 00:25:23,760 EVEN THOUGH DENTISTS WERE LESS 659 00:25:23,760 --> 00:25:26,080 LIKELY TO SELF-TEST, I DON'T 660 00:25:26,080 --> 00:25:29,000 KNOW WHAT THE ROOT CAUSE WOULD 661 00:25:29,000 --> 00:25:31,440 BE BUT WE'RE ADVOCATES AND EVEN 662 00:25:31,440 --> 00:25:34,040 DELIVERED VACCINES SO THIS WAS 663 00:25:34,040 --> 00:25:36,040 AN IMPORTANT STUDY OF AN 664 00:25:36,040 --> 00:25:36,920 OUTCOME. 665 00:25:36,920 --> 00:25:40,280 NOW, IN THIS MAGICAL PERIOD, I 666 00:25:40,280 --> 00:25:41,880 HAVE THIS POSITIVE ATTITUDE 667 00:25:41,880 --> 00:25:44,120 ABOUT WHAT THE PANDEMIC BROUGHT 668 00:25:44,120 --> 00:25:46,560 TO THE CAMPUS CAME THIS 669 00:25:46,560 --> 00:25:47,840 REMARKABLE PROGRAM CALLED RADX 670 00:25:47,840 --> 00:25:52,520 THAT WAS RUN BY THE NIBIB, BRUCE 671 00:25:52,520 --> 00:25:54,320 THORNBERG, THAT LOOKED AT 672 00:25:54,320 --> 00:25:55,200 DIAGNOSTICS THAT WOULD HELP AND 673 00:25:55,200 --> 00:25:59,240 THERE WERE 11 AWARDS MADE 674 00:25:59,240 --> 00:26:00,520 THROUGH THIS PARTICULAR OUTREACH 675 00:26:00,520 --> 00:26:02,920 WHICH WAS TO LOOK FOR BIO 676 00:26:02,920 --> 00:26:04,640 SENSORS FOR SCREENING, 677 00:26:04,640 --> 00:26:05,760 DIAGNOSING AND MONITORING COVID 678 00:26:05,760 --> 00:26:07,160 WITH THE INTENTION THAT THESE 679 00:26:07,160 --> 00:26:09,880 WERE TRANSFERABLE AND 680 00:26:09,880 --> 00:26:12,280 TRANSLATABLE FOR YEARS TO COME. 681 00:26:12,280 --> 00:26:17,200 AND I'M JUST GOING TO GO THROUGH 682 00:26:17,200 --> 00:26:17,840 THESE. 683 00:26:17,840 --> 00:26:19,520 USING TECHNOLOGY IT'S AMAZE WAG 684 00:26:19,520 --> 00:26:20,120 YOU CAN DO. 685 00:26:20,120 --> 00:26:21,720 IT REALLY IS. 686 00:26:21,720 --> 00:26:26,320 IF WE CAN ADAPT TO LOOKING AT 687 00:26:26,320 --> 00:26:27,840 THE STATE OF THE BREATH OR 688 00:26:27,840 --> 00:26:30,160 ANYTHING LIKE THAT THAT WOULD 689 00:26:30,160 --> 00:26:32,840 HELP US PREVENT EARLY AND EARLY 690 00:26:32,840 --> 00:26:35,200 DIAGNOSIS CONDITIONS THAT WE ARE 691 00:26:35,200 --> 00:26:36,400 WRESTLING WITH, THIS WOULD BE 692 00:26:36,400 --> 00:26:38,760 GREAT AND IT'S ALL HOOKED ON TO 693 00:26:38,760 --> 00:26:41,000 SOFTWARE AND YOU CAN ANALYZE 694 00:26:41,000 --> 00:26:43,600 DATA EFFECTIVELY. 695 00:26:43,600 --> 00:26:45,920 WE HAVE AN ANTI BODY AND MULTI 696 00:26:45,920 --> 00:26:48,440 MODEL PLATFORM THAT ACTUALLY 697 00:26:48,440 --> 00:26:50,560 USES ANTIBODIES IN NOW YOU GO 698 00:26:50,560 --> 00:26:53,760 FROM THE MACRO SYSTEM TO A 699 00:26:53,760 --> 00:26:56,600 NANO-CENSUS SYSTEM SO NANO 700 00:26:56,600 --> 00:26:58,960 CENSUS SYSTEMS THAT WOULD ALLOW 701 00:26:58,960 --> 00:27:02,040 US TO POINT OF CARE APPLICATIONS 702 00:27:02,040 --> 00:27:04,120 COME UP WITH SCREENING TOOLS 703 00:27:04,120 --> 00:27:07,000 THAT WOULD BE APPLICABLE FOR THE 704 00:27:07,000 --> 00:27:07,400 FUTURE. 705 00:27:07,400 --> 00:27:10,320 THE ANTIGEN RAPID SLIDER TEST 706 00:27:10,320 --> 00:27:12,040 REALLY BRINGS BACK TO THE 707 00:27:12,040 --> 00:27:14,440 FOREFRONT THE IMPORTANCE OF SAL 708 00:27:14,440 --> 00:27:16,080 A VARY DIAGNOSTICS AND IT 709 00:27:16,080 --> 00:27:17,440 REMAINS THAT PER VEILED THROUGH 710 00:27:17,440 --> 00:27:20,480 THE PANDEMIC OF HIGHLIGHTED THE 711 00:27:20,480 --> 00:27:21,920 ORAL GUT ACCESS AND ITS 712 00:27:21,920 --> 00:27:23,480 IMPORTANT IN TRANSMITTING THE 713 00:27:23,480 --> 00:27:27,360 VIRUS WAS HIGHLIGHTED BY BLACK 714 00:27:27,360 --> 00:27:29,840 WARNER AND HIS TEAM OF 715 00:27:29,840 --> 00:27:31,480 COLLABORATORS AND ADA TO SHOW 716 00:27:31,480 --> 00:27:34,560 THAT IN FACT, THE VIRUS CAN 717 00:27:34,560 --> 00:27:37,840 ATTACH TO SALIVA AND ATTACH TO 718 00:27:37,840 --> 00:27:39,080 TONGUE AND COULD ACCOUNT FOR THE 719 00:27:39,080 --> 00:27:41,360 MANY SYMPTOMS THAT PATIENTS 720 00:27:41,360 --> 00:27:41,800 EXPERIENCE. 721 00:27:41,800 --> 00:27:43,840 SO THIS CREATING THIS HOME CARE 722 00:27:43,840 --> 00:27:47,760 RAPID TEST RELIABLE BASED ON 723 00:27:47,760 --> 00:27:49,800 CHEMISTRY, IS IMPORTANT AND YOU 724 00:27:49,800 --> 00:27:51,240 CAN SEE IT'S A COLOR CHANGE THAT 725 00:27:51,240 --> 00:27:55,400 OCCURS OVER TIME. 726 00:27:55,400 --> 00:27:58,360 NOW, JUST TO GIVE YOU A QUICK, 727 00:27:58,360 --> 00:27:59,200 BRIEF RUN THROUGH WHERE WE ARE 728 00:27:59,200 --> 00:28:09,520 WITH THE REPORT. 729 00:28:09,520 --> 00:28:12,480 I WAS ONBOARDING AS A DIRECTOR 730 00:28:12,480 --> 00:28:14,600 AND FELT THIS WAS THE BEST 731 00:28:14,600 --> 00:28:15,960 PUBLIC SERVICE NIDCR TO CHAMPION 732 00:28:15,960 --> 00:28:17,680 AND DO. 733 00:28:17,680 --> 00:28:23,560 AND WE'RE VERY COMMITTED TO 734 00:28:23,560 --> 00:28:24,880 DISSEMINATING, STRATEGICALLY 735 00:28:24,880 --> 00:28:28,200 AGAIN, BUT WITH THE PURPOSE OF 736 00:28:28,200 --> 00:28:29,480 TRANSFERRING THE OWNERSHIP OF 737 00:28:29,480 --> 00:28:30,240 OUR COMMUNITIES. 738 00:28:30,240 --> 00:28:32,160 ONE OF YOU SHOULD HAVE READ THE 739 00:28:32,160 --> 00:28:34,280 EXECUTIVE SUMMARY, ONLY 25 PAGES 740 00:28:34,280 --> 00:28:41,120 LONG, THE REPORT ITSELF IS 7 # # 741 00:28:41,120 --> 00:28:48,000 0 P790PAGES LONG. 742 00:28:48,000 --> 00:28:50,200 BEN HAD TARGETED FOCUS POINTS 743 00:28:50,200 --> 00:28:51,440 THAT KIND OF CONNECTED THE 744 00:28:51,440 --> 00:28:52,880 THEMES OF REPORT, NOT LIKE IT 745 00:28:52,880 --> 00:28:54,720 WAS PRESENTED BUT IN A UNIQUE 746 00:28:54,720 --> 00:28:57,480 WAY SO THAT EDUCATORS, 747 00:28:57,480 --> 00:28:58,280 CLINICIANS, PUBLIC-HEALTH 748 00:28:58,280 --> 00:29:00,680 DENTIST AND RESEARCHERS WOULD BE 749 00:29:00,680 --> 00:29:01,960 INSPIRED BY WHAT WE NEED FOR THE 750 00:29:01,960 --> 00:29:03,960 FUTURE AND YOU CAN SEE HERE THE 751 00:29:03,960 --> 00:29:06,360 SOCIAL IMMEDIATE WHY HITS ALMOST 752 00:29:06,360 --> 00:29:07,920 10 MILLION AND WE KEEP TRACK OF 753 00:29:07,920 --> 00:29:09,480 THAT VERY RELIABLY. 754 00:29:09,480 --> 00:29:10,640 I THANK THE OFFICE OF 755 00:29:10,640 --> 00:29:12,560 COMMUNICATION FOR DOING THIS FOR 756 00:29:12,560 --> 00:29:12,760 US. 757 00:29:12,760 --> 00:29:16,480 BUT WHAT STRUCK ME WAS THIS 758 00:29:16,480 --> 00:29:17,640 COMMENT THAT WE PUT TOGETHER FOR 759 00:29:17,640 --> 00:29:22,400 THE NEW ENGLAND JUNE ENGLISH JO. 760 00:29:22,400 --> 00:29:25,040 IN OUR COUNTRY TODAY, PEOPLE 761 00:29:25,040 --> 00:29:26,480 EXPERIENCE ORAL HEALTH 762 00:29:26,480 --> 00:29:26,960 DIFFERENTLY. 763 00:29:26,960 --> 00:29:30,880 MANY TIMES NOT BECAUSE OF THEIR 764 00:29:30,880 --> 00:29:32,280 OWN THOUGHTS. 765 00:29:32,280 --> 00:29:34,240 BUT BECAUSE OF AGE, ECONOMIC 766 00:29:34,240 --> 00:29:34,480 STATUS. 767 00:29:34,480 --> 00:29:36,240 WE HAVE TO KEEP IN MIND DESPITE 768 00:29:36,240 --> 00:29:37,760 THE SIGNS AND TECHNOLOGY THAT 769 00:29:37,760 --> 00:29:39,720 WE'RE PROUD OF IN THE LAST 20 770 00:29:39,720 --> 00:29:44,120 YEARS, WE HAVE FOUR OUT OF FIVE 771 00:29:44,120 --> 00:29:45,560 CHILDREN WITH CARE EASE AND 772 00:29:45,560 --> 00:29:49,720 PROBABLY THE MOST COMMON REASON 773 00:29:49,720 --> 00:29:52,440 TO VISIT AN EMERGENCY ROOM BUT 774 00:29:52,440 --> 00:29:54,200 PRESCRIBE DRUGS THAT BECOME 775 00:29:54,200 --> 00:29:56,720 ADDICTIVE TO SO THERE'S A CIRC 776 00:29:56,720 --> 00:30:00,240 OF OF EVENTS, THAT WE NEED TO 777 00:30:00,240 --> 00:30:01,520 ESCAPE WITH SOLUTIONS AND THE 778 00:30:01,520 --> 00:30:03,160 ONLY SOLUTION, AS JENNIFER WILL 779 00:30:03,160 --> 00:30:05,160 ALWAYS TELL ME, WE NEED THE 780 00:30:05,160 --> 00:30:06,880 EVIDENCE AND WE NEED TO 781 00:30:06,880 --> 00:30:09,360 EMPHASIZE PREVENTION SO WE ARE 782 00:30:09,360 --> 00:30:14,280 BALANCING IT BETTER WITH 783 00:30:14,280 --> 00:30:15,560 INTERVENTIONAL-TYPE RESEARCH 784 00:30:15,560 --> 00:30:15,880 STRAT GEESE. 785 00:30:15,880 --> 00:30:17,360 I WAS REALLY ENCOURAGED TO SEE 786 00:30:17,360 --> 00:30:19,240 THIS AND I THANK SANTA FE AND 787 00:30:19,240 --> 00:30:20,760 THE LEADERS IN OUR COMMUNITY FOR 788 00:30:20,760 --> 00:30:26,640 REALLY BEING THAT VOICE FOR US. 789 00:30:26,640 --> 00:30:28,560 THE CURRENT ADMINISTRATION IS 790 00:30:28,560 --> 00:30:30,280 CONSIDER DENTAL COVERAGE. 791 00:30:30,280 --> 00:30:32,200 IT'S A FOOT IN THE DOOR AND I'M 792 00:30:32,200 --> 00:30:34,400 HOPING IT GETS APPROVED AND WE 793 00:30:34,400 --> 00:30:37,320 HAVE ORAL HEALTH AVAILABLE FOR 794 00:30:37,320 --> 00:30:38,160 ALL. 795 00:30:38,160 --> 00:30:41,320 NOW, EVEN THOUGH THE STRATEGIC 796 00:30:41,320 --> 00:30:42,440 PLAN TRULY DEVELOPED 797 00:30:42,440 --> 00:30:43,080 INDEPENDENTLY BECAUSE WE DIDN'T 798 00:30:43,080 --> 00:30:44,400 KNOW WHAT WAS THE DETAILS OF 799 00:30:44,400 --> 00:30:46,880 WHAT WAS IN THE REPORT, WE WERE 800 00:30:46,880 --> 00:30:48,520 DOING IT AT THE SAME TIME, IT'S 801 00:30:48,520 --> 00:30:50,560 AMAZING HOW THEY IN FACT HAVE 802 00:30:50,560 --> 00:30:52,240 PARALLELS AND THE STRATEGIC PLAN 803 00:30:52,240 --> 00:30:54,160 PLACES THE PATIENT IN THE MIDDLE 804 00:30:54,160 --> 00:30:56,080 AND IT EMPHASIZES THAT ALL ARMS 805 00:30:56,080 --> 00:30:57,120 RESEARCHER ARE IMPORTANT AND 806 00:30:57,120 --> 00:31:03,760 THEY ALL FEED INTO UNDERSTANDING 807 00:31:03,760 --> 00:31:06,120 THE HEALTH AND DISEASE, AND THAT 808 00:31:06,120 --> 00:31:08,040 ALL OF THESE CONNECT IN THIS 809 00:31:08,040 --> 00:31:12,080 CONTINUUM WHICH MEANS THAT OUR 810 00:31:12,080 --> 00:31:14,200 STRATEGIES AND FUNDING AND 811 00:31:14,200 --> 00:31:16,000 BRINGING TOGETHER COMMUNITIES 812 00:31:16,000 --> 00:31:19,840 HAS TO BE MORPHED TO MATCH THIS 813 00:31:19,840 --> 00:31:20,080 PLAN. 814 00:31:20,080 --> 00:31:23,880 WORD OF WISDOM, CAME FROM 815 00:31:23,880 --> 00:31:25,400 JENNIFER AND SO WE ARE, WE ARE 816 00:31:25,400 --> 00:31:27,440 ACTUALLY CONNECTING IT'S SUCH 817 00:31:27,440 --> 00:31:30,800 THAT OUR LEADERS AT NIDCR, ARE 818 00:31:30,800 --> 00:31:32,760 BEING EVALUATED IN THEIR 819 00:31:32,760 --> 00:31:33,960 PERFORMANCE EVALUATIONS EVERY 820 00:31:33,960 --> 00:31:34,160 YEAR. 821 00:31:34,160 --> 00:31:36,080 THEIR ANNUAL REPORTS, AS TO WHAT 822 00:31:36,080 --> 00:31:38,960 PROGRESS IS MADE FOR EACH OF OUR 823 00:31:38,960 --> 00:31:40,240 SPECIFIC GOALS THAT ARE OUTLINED 824 00:31:40,240 --> 00:31:43,440 IN THE PLAN, ALL CONNECTED TO 825 00:31:43,440 --> 00:31:44,640 SURGEON GENERAL'S CALL FOR 826 00:31:44,640 --> 00:31:45,920 ACTION AND NOT SURGEON GENERAL 827 00:31:45,920 --> 00:31:47,680 THE ORAL HEALTH IN AMERICA 828 00:31:47,680 --> 00:31:49,520 REPORT CALLS FOR ACTION AND I 829 00:31:49,520 --> 00:31:51,920 THINK THAT WOULD LEAD THEN THAT 830 00:31:51,920 --> 00:31:53,400 CONNECTIVITY WOULD LEAD TO THIS 831 00:31:53,400 --> 00:31:58,120 OUTCOME THAT WE ALL SEEK. 832 00:31:58,120 --> 00:31:59,760 SAYING THIS WITHOUT ANY 833 00:31:59,760 --> 00:32:02,320 HESITATION, WE CAN DO IT ALONE. 834 00:32:02,320 --> 00:32:04,240 JUST NOT THE FEDERAL AGENCY WITH 835 00:32:04,240 --> 00:32:07,360 THE FUNDS TO DISTRIBUTE BUT THE 836 00:32:07,360 --> 00:32:11,280 FEDERAL AGENCIES CHARGE TO MAKE 837 00:32:11,280 --> 00:32:13,440 ORAL HEALTH AVAILABLE FOR ALL 838 00:32:13,440 --> 00:32:14,040 THROUGH SCHOLARSHIP AND 839 00:32:14,040 --> 00:32:15,040 SCIENTIFIC DISCOVERY AND WE HAVE 840 00:32:15,040 --> 00:32:19,160 TO DO IT WITH CLINICAL 841 00:32:19,160 --> 00:32:20,320 CLINICIANS AND EDUCATORS WITH 842 00:32:20,320 --> 00:32:22,320 THE SENSE THAT WE HAVE TO HAVE A 843 00:32:22,320 --> 00:32:25,400 WORKFORCE, A RESEARCH WORKFORCE, 844 00:32:25,400 --> 00:32:27,440 THAT INCLUDES ALL COMMUNITIES IN 845 00:32:27,440 --> 00:32:29,320 THEIR STUDIES AND WHO WILL 846 00:32:29,320 --> 00:32:30,640 PARTICIPATE IN RESEARCH 847 00:32:30,640 --> 00:32:31,400 THEMSELVES AND BECAUSE THAT 848 00:32:31,400 --> 00:32:33,080 WOULD REPRESENT THE DEMOGRAPHICS 849 00:32:33,080 --> 00:32:34,280 OF OUR COUNTRY. 850 00:32:34,280 --> 00:32:36,400 THERE'S ONE THING THAT'S MORE 851 00:32:36,400 --> 00:32:38,600 IMPORTANT TO THE OTHER, THEY 852 00:32:38,600 --> 00:32:40,320 HAVE MUTUALLY REINFORCING AND 853 00:32:40,320 --> 00:32:43,600 THE SYSTEM BENEFITS IF ONE 854 00:32:43,600 --> 00:32:43,880 SUCCEEDS. 855 00:32:43,880 --> 00:32:46,960 SO I LOVE THIS DIAGRAM. 856 00:32:46,960 --> 00:32:48,440 IT CAME FROM THE UNIVERSITY OF 857 00:32:48,440 --> 00:32:50,240 UTAH WHEN I WAS THERE. 858 00:32:50,240 --> 00:32:51,320 THIS IS SO CONSTRUCTIVE FOR ME 859 00:32:51,320 --> 00:32:52,160 TO UNDERSTAND THE DIFFERENCE 860 00:32:52,160 --> 00:32:53,880 BETWEEN EQUALITY AND EQUITY. 861 00:32:53,880 --> 00:32:56,040 EQUALITY PERHAPS IS NOT ENOUGH. 862 00:32:56,040 --> 00:32:57,320 BY GIVING PEOPLE, EVERYONE THE 863 00:32:57,320 --> 00:32:58,640 SAME BENEFITS AND EVERYONE 864 00:32:58,640 --> 00:33:00,560 ACTUALLY HAS A DIFFERENT SET OF 865 00:33:00,560 --> 00:33:01,160 NEEDS. 866 00:33:01,160 --> 00:33:04,000 SO, WHAT WE SEEK IS THAT JUSTICE 867 00:33:04,000 --> 00:33:07,000 WHERE WE HAVE NO BARRIERS AND AS 868 00:33:07,000 --> 00:33:09,360 FEW AS POSSIBLE BECAUSE 869 00:33:09,360 --> 00:33:10,920 PREJUDICE AND BIASES WILL EXIST 870 00:33:10,920 --> 00:33:14,080 IT'S JUST WHAT WE HAVE IN THE 871 00:33:14,080 --> 00:33:15,200 CAPITALISTIC SOCIETY. 872 00:33:15,200 --> 00:33:16,840 WOULD THAT BE WORK FOR THAT 873 00:33:16,840 --> 00:33:17,800 UNIFORM TOGETHERNESS IS 874 00:33:17,800 --> 00:33:19,040 IMPORTANT AND NIDCR IS TAKING 875 00:33:19,040 --> 00:33:20,960 THAT VERY SERIOUSLY AND IT'S 876 00:33:20,960 --> 00:33:23,600 PART OF AN CAMPUS WIDE PLAN 877 00:33:23,600 --> 00:33:27,280 CALLED UNITE AND MANY OF OUR 878 00:33:27,280 --> 00:33:28,080 NISH IT WAS COMING THROUGH NIH 879 00:33:28,080 --> 00:33:29,520 THAT WE LEARNED FROM ALL THE 880 00:33:29,520 --> 00:33:29,720 TIME. 881 00:33:29,720 --> 00:33:31,640 WE GET TRAINED AND WE UNDERSTAND 882 00:33:31,640 --> 00:33:33,160 DIFFERENCES AND MUCH BETTER THAN 883 00:33:33,160 --> 00:33:35,640 WE DID BEFORE AND THIS REALLY 884 00:33:35,640 --> 00:33:37,320 RELATES TO OUR FUNDING 885 00:33:37,320 --> 00:33:39,480 STATISTICS THAT IS IMPROVING 886 00:33:39,480 --> 00:33:40,960 STEADILY, MORE EARLY STAGE 887 00:33:40,960 --> 00:33:43,040 INVESTIGATORS GETTING FUNDED AND 888 00:33:43,040 --> 00:33:45,800 FAR MORE UNDER REPRESENTED 889 00:33:45,800 --> 00:33:48,960 INDIVIDUALS BEING SUPPORTED IN 890 00:33:48,960 --> 00:33:52,600 DIFFERENT WAYS AND GRASS ROOTS 891 00:33:52,600 --> 00:33:53,760 MOVEMENTS WHO TRAIN INDIVIDUALS 892 00:33:53,760 --> 00:33:55,400 TO WRITE GRANTS AND HAVE THE 893 00:33:55,400 --> 00:33:57,520 MENTORING THAT THEY NEED IN AN 894 00:33:57,520 --> 00:33:58,960 INSTITUTION WHOSE CULTURE IS 895 00:33:58,960 --> 00:34:00,680 ACTUALLY CREATING THE BETTER 896 00:34:00,680 --> 00:34:01,880 SENSE OF BELONGING BECAUSE IF WE 897 00:34:01,880 --> 00:34:03,320 HAVE BELONGING, IT SEEMS LIKE 898 00:34:03,320 --> 00:34:05,760 THE OTHER PIECES WOULD NATURALLY 899 00:34:05,760 --> 00:34:12,040 FALL IN PLACE, AND THESE TWO ARE 900 00:34:12,040 --> 00:34:13,120 REALLY NIDCR'S PRIMARY MISSIONS 901 00:34:13,120 --> 00:34:15,640 AND THEY'VE BEEN LED BY JENNIFER 902 00:34:15,640 --> 00:34:18,440 AND HER TEAM, KELLY FROM 903 00:34:18,440 --> 00:34:23,400 DIVISION OF TR INTRAMURAL RESEAS 904 00:34:23,400 --> 00:34:23,880 WELL. 905 00:34:23,880 --> 00:34:25,480 THE TRANS NIH PROGRAMS AND WE 906 00:34:25,480 --> 00:34:26,720 ARE LEVERAGING FROM AND BECAUSE 907 00:34:26,720 --> 00:34:28,240 AS YOU KNOW OUR BUDGET DOESN'T 908 00:34:28,240 --> 00:34:30,360 MATCH THAT OF THE BIGGINS TO USE 909 00:34:30,360 --> 00:34:32,160 THE AND THE MULTI BILLION DOLLAR 910 00:34:32,160 --> 00:34:34,160 FUNDING MECHANISMS. 911 00:34:34,160 --> 00:34:38,240 SO WE HAVE TO TAKE ADVANTAGE 912 00:34:38,240 --> 00:34:41,560 RELATE TODAY PAIN AND AND WE 913 00:34:41,560 --> 00:34:43,000 HAVE RIGHT NOW A FUNDING 914 00:34:43,000 --> 00:34:53,520 OPPORTUNITY THAT IS LOOKING WE 915 00:34:54,400 --> 00:34:55,800 HAVE A STRIKING VIEW AND THEY 916 00:34:55,800 --> 00:34:57,800 ARE REMARKABLE AND CHARGING IN 917 00:34:57,800 --> 00:34:58,640 EVERY RESPECT. 918 00:34:58,640 --> 00:35:00,160 THERE'S NOTHING LIKE DENTAL PAIN 919 00:35:00,160 --> 00:35:02,400 WHERE YOU HAVE NO ROOM TO 920 00:35:02,400 --> 00:35:04,640 ACTUALLY SPAN AND YOU HAVE HARD 921 00:35:04,640 --> 00:35:05,600 TISSUE AND CASING. 922 00:35:05,600 --> 00:35:07,960 YOU HAVE THE PAIN OF CANCERS AND 923 00:35:07,960 --> 00:35:10,400 YOU HAVE -- I CAN GO ON AND ON. 924 00:35:10,400 --> 00:35:13,320 WE HAVE VERY CHALLENGING 925 00:35:13,320 --> 00:35:14,320 SITUATIONS THAT NEED TO BE 926 00:35:14,320 --> 00:35:15,480 LOOKED AT. 927 00:35:15,480 --> 00:35:19,600 LOOKING AT ALL COMPLICATIONS 928 00:35:19,600 --> 00:35:21,200 IT'S OPEN NOW TO LOOKING AT THE 929 00:35:21,200 --> 00:35:23,360 DRY MOUTH THAT IS -- OR THE LACK 930 00:35:23,360 --> 00:35:25,200 OF SALIVA THAT IS SITUATIONS 931 00:35:25,200 --> 00:35:27,440 THAT ARE NORMALLY ACCOMPANY 932 00:35:27,440 --> 00:35:28,760 LONG-TERM DRUG USE AND FINDING 933 00:35:28,760 --> 00:35:31,840 WAYS IN WHICH WE CAN CIRCUMVENT 934 00:35:31,840 --> 00:35:34,400 AND MITIGATE SIDE EFFECTS FROM 935 00:35:34,400 --> 00:35:36,600 NEW THERAPIES THAT HAVE COME UP. 936 00:35:36,600 --> 00:35:41,560 THIS IS A FASCINATING INITIATIVE 937 00:35:41,560 --> 00:35:44,880 THAT WAS A PARTING GIFT TO FROM 938 00:35:44,880 --> 00:35:45,120 FRANCIS. 939 00:35:45,120 --> 00:35:47,440 FOR GENE THERAPY IS THAT USES 940 00:35:47,440 --> 00:35:50,160 ADD NOR VIRAL VECTORS REAPPROVED 941 00:35:50,160 --> 00:35:51,600 SO THE PLATFORM THAT GOES 942 00:35:51,600 --> 00:35:53,760 THROUGH FDA APPROVAL FOR SAFETY 943 00:35:53,760 --> 00:35:55,880 AND EFFICACY BY ITSELF AND MADE 944 00:35:55,880 --> 00:35:57,560 AVAILABLE AS THE PLATFORM IN 945 00:35:57,560 --> 00:35:58,960 WHICH INDIVIDUALS CAN PUT THE 946 00:35:58,960 --> 00:36:02,600 GENE OF INTEREST OR THE CDNA 947 00:36:02,600 --> 00:36:04,640 INTEREST TARGETING THE TISSUE 948 00:36:04,640 --> 00:36:07,480 INTEREST SO YOU FAST TRACK A 949 00:36:07,480 --> 00:36:08,920 THERAPY THROUGH FDA WITHOUT 950 00:36:08,920 --> 00:36:11,840 HAVING TO GO THROUGH THE INITIAL 951 00:36:11,840 --> 00:36:14,280 APPROVAL AND THERE WAS A RFA 952 00:36:14,280 --> 00:36:18,000 RELEASED AND THERE WERE 14 953 00:36:18,000 --> 00:36:20,440 CANDIDATE GENES THAT MADE THE 954 00:36:20,440 --> 00:36:22,440 CUT WHICH THREE RELATE TO WHAT 955 00:36:22,440 --> 00:36:25,640 WE DO IN ORAL HEALTH, FOP 956 00:36:25,640 --> 00:36:27,720 PARTICULARLY AND ANOTHER TWO 957 00:36:27,720 --> 00:36:27,960 SYNDROMES. 958 00:36:27,960 --> 00:36:32,280 I WAS HOPING I COULD HAD A GROUP 959 00:36:32,280 --> 00:36:34,360 OF THE REAL EXPERTISE LIES 960 00:36:34,360 --> 00:36:36,200 OUTSIDE THE U.S. SO THEY WEREN'T 961 00:36:36,200 --> 00:36:38,520 QUITE ELIGIBLE TO COMPETE. 962 00:36:38,520 --> 00:36:42,360 I WANT TO LET EVERYONE KNOW THE 963 00:36:42,360 --> 00:36:43,880 LOAN REPAYMENT PROGRAM IS 964 00:36:43,880 --> 00:36:44,960 BROADENING THE SCOPE OF 965 00:36:44,960 --> 00:36:46,080 INFLUENCE HERE. 966 00:36:46,080 --> 00:36:47,800 IT USED TO BE ONLY FOCUSED ON 967 00:36:47,800 --> 00:36:50,680 THOSE WHO WERE FACULTY, 968 00:36:50,680 --> 00:36:53,000 DEPARTMENTISTS, SCIENTISTS AND 969 00:36:53,000 --> 00:36:54,520 PEDIATRIC RESEARCH AND IT'S 970 00:36:54,520 --> 00:36:56,280 EXTENDED TO CLINICAL HEALTH 971 00:36:56,280 --> 00:36:58,880 DISPARITIES RESEARCH AND OF 972 00:36:58,880 --> 00:37:01,080 COURSE, AREAS THAT ARE POLITICAL 973 00:37:01,080 --> 00:37:02,520 TO HUMAN HEALTH. 974 00:37:02,520 --> 00:37:05,120 SO WE SUPPORT THAT AND IT'S 975 00:37:05,120 --> 00:37:07,600 CALLED REACH AND WE ARE HOPING 976 00:37:07,600 --> 00:37:09,840 FROM FAR MORE INTEREST AND 977 00:37:09,840 --> 00:37:11,160 INVOLVEMENT FROM OUR COMMUNITY 978 00:37:11,160 --> 00:37:13,160 BECAUSE AS YOU KNOW, DENTAL 979 00:37:13,160 --> 00:37:14,680 SCHOOL TUITION AND LOANS ARE 980 00:37:14,680 --> 00:37:17,280 REALLY ON THE RISE AND I DON'T 981 00:37:17,280 --> 00:37:19,320 SEE THAT IS GOING TO REVERSE IN 982 00:37:19,320 --> 00:37:22,040 THE NEAR FUTURE BECAUSE OF THE 983 00:37:22,040 --> 00:37:23,920 PANDEMIC TOLL ON CLINICAL 984 00:37:23,920 --> 00:37:24,600 REVENUES. 985 00:37:24,600 --> 00:37:26,400 SO WHEN I WAS HERE THE LAST 986 00:37:26,400 --> 00:37:30,120 COUNCIL WHEN LARRY TABAK SPOKE 987 00:37:30,120 --> 00:37:32,600 AND I PROCEEDED HIM, HE REALLY 988 00:37:32,600 --> 00:37:34,960 BROUGHT TO LIFE THE SUCCESSES 989 00:37:34,960 --> 00:37:36,960 FROM THE DIVISION OF INTRAMURAL 990 00:37:36,960 --> 00:37:37,920 RESEARCH AND I'D LIKE FOR 991 00:37:37,920 --> 00:37:41,120 COUNCIL FOR ME TO KIND OF SHARE 992 00:37:41,120 --> 00:37:43,840 THE VIEW THE PROGRESS AND THE 993 00:37:43,840 --> 00:37:48,040 THINKING AND THE SIGNIFICANT 994 00:37:48,040 --> 00:37:49,560 ADVANCE FROM OTHER GROUPS AS 995 00:37:49,560 --> 00:37:50,000 WELL. 996 00:37:50,000 --> 00:37:52,120 TODAY WE'LL FOCUS ON JANICE 997 00:37:52,120 --> 00:37:54,160 LEE'S LEADERSHIP AND HER SUCCESS 998 00:37:54,160 --> 00:37:57,320 WITH THE OFFICE OF CLINICAL 999 00:37:57,320 --> 00:37:58,640 DIRECTOR WHICH IS PART OF THE 1000 00:37:58,640 --> 00:38:01,360 DIVISION OF INTRAMURAL RESEARCH 1001 00:38:01,360 --> 00:38:03,280 BUT STANDS AS AN INDEPENDENT 1002 00:38:03,280 --> 00:38:03,800 ENTITY. 1003 00:38:03,800 --> 00:38:06,920 VERY COLLABORATIVE WITH THE 1004 00:38:06,920 --> 00:38:09,400 OTHER ONE AND LILLIAN'S WORK IN 1005 00:38:09,400 --> 00:38:11,080 STRAT MURAL I SCRATCH MY HEAD TO 1006 00:38:11,080 --> 00:38:13,160 THINK OF WHAT A REMARKABLE SET 1007 00:38:13,160 --> 00:38:15,600 OF ACHIEVEMENTS THESE GROUPS 1008 00:38:15,600 --> 00:38:20,400 HAVE MADE. 1009 00:38:20,400 --> 00:38:21,440 SO, FOR EVERYONE THAT HASN'T 1010 00:38:21,440 --> 00:38:23,400 BEEN TO NIH, OUR PRESENCE IS 1011 00:38:23,400 --> 00:38:25,280 FELT IN BUILDING 10 WHERE WE SEE 1012 00:38:25,280 --> 00:38:31,760 PATIENTS WITH RARE AND 1013 00:38:31,760 --> 00:38:33,440 UNDIAGNOSED CONDITIONS ACROSS 1014 00:38:33,440 --> 00:38:34,880 THIS AMAZING COMPLEX OF BUILDING 1015 00:38:34,880 --> 00:38:37,520 WHERE THE LATEST CLINICAL TRIALS 1016 00:38:37,520 --> 00:38:39,160 IS ON GOING AND THREATENING 1017 00:38:39,160 --> 00:38:40,760 DISEASES ARE BEING COMBATED SO 1018 00:38:40,760 --> 00:38:43,160 THERE WAS A TEAM OF DENTIST 1019 00:38:43,160 --> 00:38:44,760 STAFF, DENTIST HOSPITAL AND 1020 00:38:44,760 --> 00:38:45,920 NURSES THAT WORK TOGETHER FOR 1021 00:38:45,920 --> 00:38:50,280 THE BENEFIT OF THIS PATIENTS. 1022 00:38:50,280 --> 00:38:54,040 THE INVESTIGATORS, THE SEVEN OF 1023 00:38:54,040 --> 00:38:55,600 THEM, ALSO ARE PART OF THE 1024 00:38:55,600 --> 00:38:57,560 DIVISION OF INTRAMURAL RESEARCH 1025 00:38:57,560 --> 00:39:00,480 ARE ENGAGE IN VERY IMPORTANT 1026 00:39:00,480 --> 00:39:01,760 AREAS OF RESEARCH. 1027 00:39:01,760 --> 00:39:04,280 THEY'RE NOT AS REPRESENTED AS 1028 00:39:04,280 --> 00:39:06,360 WELL IN STRAT MURAL AND FOR THAT 1029 00:39:06,360 --> 00:39:08,120 ALONE, THIS UNIT PLAYS A VERY 1030 00:39:08,120 --> 00:39:13,560 IMPORTANT ROLE AND I LIS LISTEM 1031 00:39:13,560 --> 00:39:15,000 HERE EACH ONE OF THEM THRIVING 1032 00:39:15,000 --> 00:39:20,120 IN THEIR OWN RIGHT AND THE 1033 00:39:20,120 --> 00:39:22,120 PATIENT IS AT AT THERE SO THEY 1034 00:39:22,120 --> 00:39:23,200 SEE PATIENTS WITH THESE 1035 00:39:23,200 --> 00:39:24,480 CONDITIONS AND TREATING THEM 1036 00:39:24,480 --> 00:39:26,040 WITH THERAPY UNDER APPROVAL NOW 1037 00:39:26,040 --> 00:39:30,400 OR IN TESTING AND MAKING A 1038 00:39:30,400 --> 00:39:35,400 DIFFERENCE TO THESE PATIENT HE'S 1039 00:39:35,400 --> 00:39:37,640 LIVES ONE EXAMPLE OF THE SUCCESS 1040 00:39:37,640 --> 00:39:38,840 STORY HAS GROWN OVER THE YEARS 1041 00:39:38,840 --> 00:39:40,880 FROM THE HARD-WORKING GROUP OF 1042 00:39:40,880 --> 00:39:44,880 THE BIOLOGY BRANCH OF DIR, LED 1043 00:39:44,880 --> 00:39:46,920 BY MIKE COLLINS AND Dr. 1044 00:39:46,920 --> 00:39:48,640 COLLINS AND THEY LITERALLY GO 1045 00:39:48,640 --> 00:39:53,720 FROM TRANSLATIONAL TO BENCH TO 1046 00:39:53,720 --> 00:39:55,280 BEDSIDE WITH AMAZING PROGRESS 1047 00:39:55,280 --> 00:39:57,400 MADE IN THESE PRE PRINCIPLE 1048 00:39:57,400 --> 00:39:58,840 AREAS AND WE WOULD BE DEDICATING 1049 00:39:58,840 --> 00:40:02,440 ONE OF THOSE IN A SYMPOSIUM NEXT 1050 00:40:02,440 --> 00:40:04,560 YEAR SO THAT WE BRING FOCUS AND 1051 00:40:04,560 --> 00:40:07,360 BRING THIS TO THE COMMUNITY. 1052 00:40:07,360 --> 00:40:09,280 YOU CAN SEE IN ALL OF THESE 1053 00:40:09,280 --> 00:40:11,920 CONDITIONS THAT THERE'S THAT 1054 00:40:11,920 --> 00:40:14,360 NATURAL TRANSITION FROM 1055 00:40:14,360 --> 00:40:15,800 UNDERSTANDING HISTORY TO DOING 1056 00:40:15,800 --> 00:40:19,200 ROBUST GENETICS UNDERSTANDING 1057 00:40:19,200 --> 00:40:20,760 THE MOLECULAR MECHANISM WITH THE 1058 00:40:20,760 --> 00:40:24,160 GOAL OF COMING UP WITH A 1059 00:40:24,160 --> 00:40:24,360 THERAPY. 1060 00:40:24,360 --> 00:40:27,520 HERE IS AN EXAMPLE OF WHAT IS 1061 00:40:27,520 --> 00:40:33,840 HAPPENED IN EACH OF THESE AREAS 1062 00:40:33,840 --> 00:40:38,920 AND IT'S A FGF BIOLOGY AND 1063 00:40:38,920 --> 00:40:41,880 SIGNALING FASCINATING AND NOW 1064 00:40:41,880 --> 00:40:43,520 WHAT IS REMARKABLE IS THAT IN 1065 00:40:43,520 --> 00:40:45,680 THE SHORT PERIOD OF TIME, THE 1066 00:40:45,680 --> 00:40:51,360 INFRASTRUCTURE FOR CREATING THAT 1067 00:40:51,360 --> 00:40:55,320 PLATFORMS WHERE THEY TAKE AN 1068 00:40:55,320 --> 00:40:58,080 IDEOLOGY ON IDEATION INTO AN 1069 00:40:58,080 --> 00:41:04,480 ACTUAL THERAPY HAS BEEN TESTED 1070 00:41:04,480 --> 00:41:05,800 IN UNION ET WHERE WE HAVE 1071 00:41:05,800 --> 00:41:08,440 SEVERAL COMPANIES, ABOUT 15 THAT 1072 00:41:08,440 --> 00:41:10,080 ARE UNDERWAY RIGHT NOW AND THAT 1073 00:41:10,080 --> 00:41:12,160 ARE TESTING NEW THERAPIES FOR 1074 00:41:12,160 --> 00:41:16,000 THESE INDIVIDUALS AND ALONG WITH 1075 00:41:16,000 --> 00:41:17,480 THE FACT THAT FOR THE FIRST TIME 1076 00:41:17,480 --> 00:41:18,920 WE HAVE FORMALIZED 1077 00:41:18,920 --> 00:41:21,200 COLLABORATIONS WITH UNIVERSITIES 1078 00:41:21,200 --> 00:41:23,240 AND INVESTIGATORS OUTSIDE NIH 1079 00:41:23,240 --> 00:41:27,760 THAT WORK, WHOSE EXPERTISE IS 1080 00:41:27,760 --> 00:41:28,920 CRITICAL FOR THE SUCCESS OF 1081 00:41:28,920 --> 00:41:29,760 THESE STUDIES. 1082 00:41:29,760 --> 00:41:31,160 YOU CAN SEE THE CONNECTIONS OF 1083 00:41:31,160 --> 00:41:33,640 THESE INVESTIGATORS, JACKIE AND 1084 00:41:33,640 --> 00:41:40,040 ALISON BOYS, MIKE COLLINS, HERE 1085 00:41:40,040 --> 00:41:42,160 IS JANICE AND THE GROUP OF OR AN 1086 00:41:42,160 --> 00:41:43,240 SURGEONS THAT COME DURING THIS 1087 00:41:43,240 --> 00:41:47,120 SUMMER PERIOD FROM HARVARD 1088 00:41:47,120 --> 00:41:49,320 UNIVERSITY TO EXPERIENCE THIS 1089 00:41:49,320 --> 00:41:50,440 SIDE OF THEIR TRAINING THEY 1090 00:41:50,440 --> 00:41:52,760 DON'T GET IN THEIR INSTITUTIONS. 1091 00:41:52,760 --> 00:41:54,600 I WOULDN'T BE GREAT OF YOU FOR 1092 00:41:54,600 --> 00:41:56,000 DOING THIS AND PATTING OURSELVES 1093 00:41:56,000 --> 00:41:57,760 ON THE BACK, IT WOULD BE 1094 00:41:57,760 --> 00:41:58,800 CREATING THE MODEL FOR THE REST 1095 00:41:58,800 --> 00:42:00,560 OF THE COUNTRY AND SHOULD OTHER 1096 00:42:00,560 --> 00:42:01,400 SCHOOLS TAKE THIS ON? 1097 00:42:01,400 --> 00:42:03,520 AND CREATE A CLINICAL RESEARCH 1098 00:42:03,520 --> 00:42:07,400 FELLOWSHIP PROGRAM THAT IS 1099 00:42:07,400 --> 00:42:09,640 IMMERSES INDIVIDUALS IN CLINICAL 1100 00:42:09,640 --> 00:42:10,920 RESEARCH METH OLD GEE THAT HAS 1101 00:42:10,920 --> 00:42:13,400 THE PATIENT IN THE CENTER. 1102 00:42:13,400 --> 00:42:14,960 THIS PROGRAM HAS NOW COMPLETED 1103 00:42:14,960 --> 00:42:17,400 ALMOST SEVEN YEARS I BELIEVE AND 1104 00:42:17,400 --> 00:42:19,480 SETTING THE STAGE IS NATIONALLY 1105 00:42:19,480 --> 00:42:23,440 VISIBLE AND IT IS AVAILABLE FOR 1106 00:42:23,440 --> 00:42:26,920 ALL WHO HAVE DDSs AND DDBHDs 1107 00:42:26,920 --> 00:42:28,160 AND CAN YOU SEE THAT INDIVIDUALS 1108 00:42:28,160 --> 00:42:30,200 DO GET PLACED WHERE THEY SHOULD 1109 00:42:30,200 --> 00:42:31,560 BE AND SO THERE'S A PLACE FOR 1110 00:42:31,560 --> 00:42:32,960 THEM AND IT'S NOT ALWAYS IN 1111 00:42:32,960 --> 00:42:34,160 DENTAL SCHOOLS BUT THEY'RE 1112 00:42:34,160 --> 00:42:35,960 LEADERS IN OUR COMMUNITY. 1113 00:42:35,960 --> 00:42:39,080 VERY HAPPY THAT NATALIA CHALMERS 1114 00:42:39,080 --> 00:42:42,720 IS THE FIRST CHIEF DENTAL 1115 00:42:42,720 --> 00:42:45,280 OFFICER FOR CMS IS IN PLACE NOW 1116 00:42:45,280 --> 00:42:46,960 AND SHE WAS A GRADUATE OF THIS 1117 00:42:46,960 --> 00:42:47,800 PROGRAM. 1118 00:42:47,800 --> 00:42:49,240 HAPPY TO HAVE SHAWN AND HIS 1119 00:42:49,240 --> 00:42:50,880 BEAUTIFUL SMILE TO HAVE HIM ON 1120 00:42:50,880 --> 00:42:55,600 BOARD AND JACKIE HELPS AND RUNS 1121 00:42:55,600 --> 00:42:57,480 THE PROGRAM WITH JANICE'S 1122 00:42:57,480 --> 00:42:57,720 GUIDANCE. 1123 00:42:57,720 --> 00:43:00,520 AND SO AGAIN, THANK YOU, MATT, 1124 00:43:00,520 --> 00:43:03,880 FOR KEEPING THE INTRAMURAL 1125 00:43:03,880 --> 00:43:05,360 PROGRAM STRONG AND ROBUST. 1126 00:43:05,360 --> 00:43:07,560 YOU'VE DONE WELL IN DIVERSIFYING 1127 00:43:07,560 --> 00:43:09,160 OUR POOL OF INVESTIGATORS, 1128 00:43:09,160 --> 00:43:10,440 TRAINEES AND THE RESEARCH THAT 1129 00:43:10,440 --> 00:43:12,800 IS MOVING CLEARLY IN TRANSLATION 1130 00:43:12,800 --> 00:43:13,520 AREAS. 1131 00:43:13,520 --> 00:43:16,000 VERY THANKFUL FOR THIS. 1132 00:43:16,000 --> 00:43:19,840 NOW, WE HAVE THE AMAZING PROGRAM 1133 00:43:19,840 --> 00:43:23,320 FOR WHICH $350 MILLION OF OUR 1134 00:43:23,320 --> 00:43:25,320 TOTAL BUDGET GOES TO, WHICH JUST 1135 00:43:25,320 --> 00:43:27,080 TO FUND YOU IN THE EXTRAMURAL 1136 00:43:27,080 --> 00:43:28,680 WORLD AND YOU CAN JUST RUN 1137 00:43:28,680 --> 00:43:30,960 THROUGH THIS LIST AND YOU SEE WE 1138 00:43:30,960 --> 00:43:32,640 COVER SO MUCH. 1139 00:43:32,640 --> 00:43:37,080 THESE ARE INDIVIDUALS, WE FUND 1140 00:43:37,080 --> 00:43:38,080 OUR PRINCE PLEA OURS AND 1141 00:43:38,080 --> 00:43:39,360 DIFFERENT KINDS OF TRAINING 1142 00:43:39,360 --> 00:43:41,160 GRANTS AND CO-OPERATIVE 1143 00:43:41,160 --> 00:43:44,040 AGREEMENTS AND AS THE AGE 1144 00:43:44,040 --> 00:43:45,400 DICTATED, WE FUNDED INDIVIDUALS 1145 00:43:45,400 --> 00:43:48,280 OR INDIVIDUAL PROJECTS AND NOW 1146 00:43:48,280 --> 00:43:51,640 THEY'RE GOING TO SEE A TREND TO 1147 00:43:51,640 --> 00:43:52,440 DECKING THE DOTS. 1148 00:43:52,440 --> 00:43:54,120 THEY CAN BE ENGAGE COMMUNITIES 1149 00:43:54,120 --> 00:43:56,360 WORKING AT DIFFERENT ASPECTS OF 1150 00:43:56,360 --> 00:43:58,360 THE PREVENTION AND WE COULD 1151 00:43:58,360 --> 00:44:00,920 BRING ALL CANCER TO THE FLOOR 1152 00:44:00,920 --> 00:44:04,280 USING THESE CROSS-CUTTING 1153 00:44:04,280 --> 00:44:04,760 THEMES. 1154 00:44:04,760 --> 00:44:06,320 NOW, IT DOESN'T ALWAYS HAVE TO 1155 00:44:06,320 --> 00:44:07,520 TAKE MONEY, SOMETIMES IT JUST 1156 00:44:07,520 --> 00:44:08,920 TAKES A COMMITMENT FROM THE 1157 00:44:08,920 --> 00:44:10,720 OUTSIDE WORLD TO CREATE THESE 1158 00:44:10,720 --> 00:44:13,160 FORMS OF COMMUNICATION SO THIS 1159 00:44:13,160 --> 00:44:14,360 IS A SHARING OF CURRENT 1160 00:44:14,360 --> 00:44:15,800 KNOWLEDGE AND BEST PRACTICES AND 1161 00:44:15,800 --> 00:44:21,000 SO HERE ARE EXAMPLES OF THE SIX 1162 00:44:21,000 --> 00:44:22,160 NOTICES OF SPECIAL INTEREST SO 1163 00:44:22,160 --> 00:44:23,800 YOU CAN SEE WHEN YOU GO THROUGH 1164 00:44:23,800 --> 00:44:25,400 THEM THAT THEY ARE DIVERSE AND 1165 00:44:25,400 --> 00:44:27,720 THEY COVER DIFFERENT ASPECTS OF 1166 00:44:27,720 --> 00:44:29,040 OUR PORTFOLIO. 1167 00:44:29,040 --> 00:44:31,600 HEALTH DISPARITIES AND DIVERSITY 1168 00:44:31,600 --> 00:44:35,800 HELP DISPARITY RESEARCH BEING 1169 00:44:35,800 --> 00:44:36,520 THE CENTER. 1170 00:44:36,520 --> 00:44:40,520 I MENTIONED THIS BEFORE, DRAWING 1171 00:44:40,520 --> 00:44:42,680 FROM THE SUCCESSES THAT OUR 1172 00:44:42,680 --> 00:44:45,960 DISTINGUISHED SPEAKER WILL 1173 00:44:45,960 --> 00:44:47,960 AMPLIFY AND CAME, THE IDEA THAT 1174 00:44:47,960 --> 00:44:51,360 IF YOU INCORPORATE IN THE 1175 00:44:51,360 --> 00:44:54,280 SYSTEMS APPROACH RESEARCH THAT 1176 00:44:54,280 --> 00:44:56,000 WOULD DRAW AGAIN IN A CONNECTED 1177 00:44:56,000 --> 00:44:58,400 WAY COMMUNITIES ACROSS OUR 1178 00:44:58,400 --> 00:45:00,760 SOCIAL AND SALIVARY COMMUNITIES 1179 00:45:00,760 --> 00:45:03,160 TO REALLY COME UP WITH 1180 00:45:03,160 --> 00:45:04,360 THERAPIES, WITH EARLY 1181 00:45:04,360 --> 00:45:05,840 INTERVENTIONS AND DIAGNOSIS TO 1182 00:45:05,840 --> 00:45:07,640 THIS COMPLEX DISEASE THAT 1183 00:45:07,640 --> 00:45:10,360 EFFECTS SO MANY AND MORE WOMEN 1184 00:45:10,360 --> 00:45:12,280 THAN MEN AND THIS WAS AWARDED TO 1185 00:45:12,280 --> 00:45:13,880 THE UNIVERSITY OF CALIFORNIA AT 1186 00:45:13,880 --> 00:45:18,760 SAN FRANCISCO LED BY CAROLINE 1187 00:45:18,760 --> 00:45:20,760 SHABOSKI WITH GREAT PARTNERSHIPS 1188 00:45:20,760 --> 00:45:23,560 WITH JOHN HOPKINS, OKLAHOMA, 1189 00:45:23,560 --> 00:45:25,840 NIDCR AND NIAMS SO WE'RE ALL ON 1190 00:45:25,840 --> 00:45:27,080 IT TOGETHER. 1191 00:45:27,080 --> 00:45:28,560 AND NED SHARP LESS, BEFORE HE 1192 00:45:28,560 --> 00:45:29,800 RETIRED, CAME ON BOARD WITH ME 1193 00:45:29,800 --> 00:45:32,560 TO KICKOFF A THINK-TANK DRAWING 1194 00:45:32,560 --> 00:45:34,160 ALL CANCER RESEARCHERS TO THE 1195 00:45:34,160 --> 00:45:40,840 FIELD AND RECOGNIZING THAT HPV 1196 00:45:40,840 --> 00:45:42,920 POSITIVE EXCEED CERVICAL CANCERS 1197 00:45:42,920 --> 00:45:45,720 IN TERMS OF HPB AND THEY'RE 1198 00:45:45,720 --> 00:45:46,000 THREATENING. 1199 00:45:46,000 --> 00:45:48,160 WE DETECT THEM TOO LATE, WE 1200 00:45:48,160 --> 00:45:50,520 DON'T HAVE RELIABLE BIOMARKERS 1201 00:45:50,520 --> 00:45:52,080 AND THE TREATMENT STRATEGIES ARE 1202 00:45:52,080 --> 00:45:56,760 SOMETIMES VERY HARSH WHERE YOU 1203 00:45:56,760 --> 00:45:59,360 TAKE OUT ALONG WITH THE TONGUE 1204 00:45:59,360 --> 00:46:01,000 BUT HUGE ISSUES FOR PATIENTS AND 1205 00:46:01,000 --> 00:46:05,040 THE PREVENTION ASPECTS STILL 1206 00:46:05,040 --> 00:46:08,800 NEEDING TO BE REINFORCED SO WITH 1207 00:46:08,800 --> 00:46:13,800 NCI WE HAVE AN INITIATIVE CALLED 1208 00:46:13,800 --> 00:46:16,280 AHEAD AND THAT I HOPE WILL DRAW 1209 00:46:16,280 --> 00:46:17,480 INDIVIDUALS FROM OUTSIDE ORAL 1210 00:46:17,480 --> 00:46:19,640 HEALTH SCIENCES TO COME TO THE 1211 00:46:19,640 --> 00:46:22,120 TABLE TO HELP US WITH IMAGING, 1212 00:46:22,120 --> 00:46:24,920 EARLY DIAGNOSIS, ET CETERA. 1213 00:46:24,920 --> 00:46:27,600 THE SAME ATTITUDE OR PHILOSOPHY 1214 00:46:27,600 --> 00:46:31,320 WAS APPLIED TO TMD AS YOU KNOW, 1215 00:46:31,320 --> 00:46:34,000 IT'S EXISTED, WE FUNDED QUITE A 1216 00:46:34,000 --> 00:46:34,160 BIT. 1217 00:46:34,160 --> 00:46:36,960 WE HAD 48 INDIVIDUAL AWARDS 1218 00:46:36,960 --> 00:46:37,200 RIGHT NOW. 1219 00:46:37,200 --> 00:46:39,560 HAVE WE REALLY COME UP WITH A 1220 00:46:39,560 --> 00:46:40,400 PATIENT-CENTERED APPROACH WAS 1221 00:46:40,400 --> 00:46:42,640 THE QUESTION WE ASKED OURSELVES. 1222 00:46:42,640 --> 00:46:45,080 WE LEARNED FROM THE ACADEMY'S 1223 00:46:45,080 --> 00:46:45,320 REPORT. 1224 00:46:45,320 --> 00:46:47,080 WE HAD THE DEDICATION OF A 1225 00:46:47,080 --> 00:46:49,800 PATIENT ADVOCACY GROUP LED BY 1226 00:46:49,800 --> 00:46:53,600 JUST INDIVIDUALS WHO CARE SO 1227 00:46:53,600 --> 00:46:54,560 DEEPLY. 1228 00:46:54,560 --> 00:46:57,000 TERRY COLLIE THANK YOU FOR THAT 1229 00:46:57,000 --> 00:47:00,760 COMMITMENT AND BROUGHT TO PLAY 1230 00:47:00,760 --> 00:47:01,760 INDIVIDUALS WHO DIFFERENT 1231 00:47:01,760 --> 00:47:02,640 INSTITUTES AND CENTERS SO IT WAS 1232 00:47:02,640 --> 00:47:05,600 A MULTI-COUNCIL WHO 1233 00:47:05,600 --> 00:47:08,080 REPRESENTATIVES THAT MADE 1234 00:47:08,080 --> 00:47:10,320 RECOMMENDATIONS WITH THE 1235 00:47:10,320 --> 00:47:12,360 WELCOMENESS AGAIN AND LILLIAN 1236 00:47:12,360 --> 00:47:16,200 THAT IT WAS THOUGHT THE BEST 1237 00:47:16,200 --> 00:47:17,440 NATIONAL COLLABORATIVE AND CAN 1238 00:47:17,440 --> 00:47:19,280 YOU SEE THAT THIS IS JUST NOT 1239 00:47:19,280 --> 00:47:22,400 INVOLVING THE JOINT ITSELF BUT 1240 00:47:22,400 --> 00:47:31,320 PERRY ARCTIC YOU LAR CONDITIONS, 1241 00:47:31,320 --> 00:47:41,560 TISSUE, AND WITH THE PATIENT AT 1242 00:47:41,560 --> 00:47:42,160 THE CENTER. 1243 00:47:42,160 --> 00:47:43,680 THANK YOU FOR THOSE WHO ACTUALLY 1244 00:47:43,680 --> 00:47:46,440 DID RESPOND TO SOUR CALLS. 1245 00:47:46,440 --> 00:47:47,600 WHAT IS THIS DOING TO YOUR 1246 00:47:47,600 --> 00:47:48,160 LIVES? 1247 00:47:48,160 --> 00:47:50,920 I WILL SAY, THAT INDIVIDUALS ARE 1248 00:47:50,920 --> 00:47:52,680 DRIVEN TO SUICIDES AND WE GET 1249 00:47:52,680 --> 00:47:54,320 THOSE NOTICES AS WELL. 1250 00:47:54,320 --> 00:47:56,720 BECAUSE OF JUST EXTREME PAIN AND 1251 00:47:56,720 --> 00:47:58,000 DISCOMFORT, NOT BEING ABLE TO 1252 00:47:58,000 --> 00:48:00,720 OPEN YOUR MOUTH, FAILED 1253 00:48:00,720 --> 00:48:01,320 SURGERIES, ET CETERA. 1254 00:48:01,320 --> 00:48:03,600 WE HAVE TO DO THIS IN A MATTER 1255 00:48:03,600 --> 00:48:05,360 THAT WOULD CREATE A WAVE OF 1256 00:48:05,360 --> 00:48:06,800 CHANGE FOR THE FUTURE. 1257 00:48:06,800 --> 00:48:09,920 AND IT INCLUDES INVOLVING MULTI 1258 00:48:09,920 --> 00:48:12,320 STAKEHOLDERS, AND WE'VE GOT TO 1259 00:48:12,320 --> 00:48:13,840 REALLY BRILLIANT GROUP OF 1260 00:48:13,840 --> 00:48:15,440 PARTNERS FROM NIH AND EDUCATING 1261 00:48:15,440 --> 00:48:17,120 AND TRAINING THE NEXT GENERATION 1262 00:48:17,120 --> 00:48:19,080 TO GET INVOLVED IN THIS 1263 00:48:19,080 --> 00:48:19,360 RESEARCH. 1264 00:48:19,360 --> 00:48:22,040 AND TO KEEP THAT ENTHUSIASM UP. 1265 00:48:22,040 --> 00:48:24,320 SO THIS IS CALLED IMPACT SO THE 1266 00:48:24,320 --> 00:48:27,400 FIRST ONE IS AHEAD AND IMPACT 1267 00:48:27,400 --> 00:48:29,040 AND THEN WE HAVE ONE MORE 1268 00:48:29,040 --> 00:48:29,280 COMING. 1269 00:48:29,280 --> 00:48:31,480 SO THIS IS THE TIMELINE IN PLACE 1270 00:48:31,480 --> 00:48:36,120 FOR THE RELEASE OF THE 1271 00:48:36,120 --> 00:48:36,960 ANNOUNCEMENT AND WE ARE 1272 00:48:36,960 --> 00:48:39,440 OBVIOUSLY WANTING TO SUPPORT A 1273 00:48:39,440 --> 00:48:41,240 PLANNING PHASE INITIALLY. 1274 00:48:41,240 --> 00:48:43,640 HOPING THAT TEAMS WILL COALESCE 1275 00:48:43,640 --> 00:48:45,240 TOGETHER IN A VERY THOUGHTFUL 1276 00:48:45,240 --> 00:48:47,320 WAY TO ADDRESS NOT ALL OF THE 1277 00:48:47,320 --> 00:48:50,000 GOALS BUT AT LEAST MANY IN A 1278 00:48:50,000 --> 00:48:53,240 VERY MULTI-DISCIPLINARY WAY. 1279 00:48:53,240 --> 00:48:54,640 WE ENCOURAGE OUTSIDE 1280 00:48:54,640 --> 00:48:56,120 PARTICIPATION FROM EXPERTS IN 1281 00:48:56,120 --> 00:48:59,200 PAIN AND NEUROSCIENCES AND 1282 00:48:59,200 --> 00:49:00,880 BIOLOGY AND IN CARTILAGE 1283 00:49:00,880 --> 00:49:02,440 REGENERATION, AND THE WHOLE 1284 00:49:02,440 --> 00:49:02,880 SPECTRUM. 1285 00:49:02,880 --> 00:49:05,480 AND AFTER THE PLANNING PHASE, WE 1286 00:49:05,480 --> 00:49:08,000 WILL VISIT THE CONCEPT OF 1287 00:49:08,000 --> 00:49:09,320 IMPLEMENTATION AND THE EXECUTION 1288 00:49:09,320 --> 00:49:10,600 OF THE RESEARCH. 1289 00:49:10,600 --> 00:49:15,320 SO THAT'S THE WAY IT'S GOING TO 1290 00:49:15,320 --> 00:49:15,640 UNFOLD. 1291 00:49:15,640 --> 00:49:17,840 THIS ONE WILL EXCITE ALL OF YOU 1292 00:49:17,840 --> 00:49:19,200 IF IT HASN'T ALREADY. 1293 00:49:19,200 --> 00:49:21,200 IT'S CALLED PRIME. 1294 00:49:21,200 --> 00:49:23,000 NOTE WE ARE PRIMED TO MOVE AHEAD 1295 00:49:23,000 --> 00:49:24,040 WITH IMPACT. 1296 00:49:24,040 --> 00:49:27,640 SO SOMEHOW THOSE THREE ACRONYMS 1297 00:49:27,640 --> 00:49:29,240 SEEM TO FIT INTO A SENTENCE THAT 1298 00:49:29,240 --> 00:49:31,320 IS MEANINGFUL FOR US AND THIS IS 1299 00:49:31,320 --> 00:49:33,720 A CULTURE-CHANGING 1300 00:49:33,720 --> 00:49:34,560 TRANSFORMATIVE PROGRAM AND COMES 1301 00:49:34,560 --> 00:49:37,160 WITH IT RISKS, I DO SOMETIMES 1302 00:49:37,160 --> 00:49:38,560 WAKE UP AT NIGHT THINKING ABOUT 1303 00:49:38,560 --> 00:49:40,200 THEM AND WORRY ABOUT IT. 1304 00:49:40,200 --> 00:49:44,360 IT'S TO CREATE DENTAL SCHOOLS 1305 00:49:44,360 --> 00:49:45,800 THE ACCEPTS OF EXCITEMENT OF 1306 00:49:45,800 --> 00:49:48,760 CURIOSITY, OF ENGAGEMENT, OF 1307 00:49:48,760 --> 00:49:50,160 BELONGING TO RESEARCH BY USING 1308 00:49:50,160 --> 00:49:52,920 THE PATIENT AT THE EXPERIMENT AS 1309 00:49:52,920 --> 00:49:55,080 WE'RE DOING ALL OUR PROCEDURES 1310 00:49:55,080 --> 00:49:58,400 IN A SAFETY NET UNIT, 1311 00:49:58,400 --> 00:50:01,080 UNPARALLELED IN OUR SOCIETY. 1312 00:50:01,080 --> 00:50:02,080 DENTAL SCHOOLS TREAT PATIENTS 1313 00:50:02,080 --> 00:50:05,000 FROM SIMPLE TO COMPLEX TO VERY 1314 00:50:05,000 --> 00:50:06,880 SPECIAL NEEDS, MEDICALLY 1315 00:50:06,880 --> 00:50:07,880 COMPROMISED, RIGHT. 1316 00:50:07,880 --> 00:50:09,880 AND WE HAVE DIGITAL TOOLS TO 1317 00:50:09,880 --> 00:50:12,360 ASSIST US IN KEEPING THOSE 1318 00:50:12,360 --> 00:50:14,440 RECORDS HOLISTIC AND ACTIVE AND 1319 00:50:14,440 --> 00:50:17,680 TO ENGAGE OUR STUDENTS AND OUR 1320 00:50:17,680 --> 00:50:19,000 FACULTY WITH SOME TRAINING, OF 1321 00:50:19,000 --> 00:50:21,200 COURSE, TO ENGAGE THEM WITH 1322 00:50:21,200 --> 00:50:24,880 CTSAs ACROSS CAMPUS SO THAT 1323 00:50:24,880 --> 00:50:28,120 SMALL SCHOOLS ARE THOUGHT THEY 1324 00:50:28,120 --> 00:50:28,840 DON'T BUILDING BECAUSE THEY 1325 00:50:28,840 --> 00:50:30,400 DON'T HAVE THE RESOURCES OR 1326 00:50:30,400 --> 00:50:31,680 INFRASTRUCTURE TO FEEL THEY CAN 1327 00:50:31,680 --> 00:50:36,160 ACTUALLY PARTNER WITH A SCHOOL 1328 00:50:36,160 --> 00:50:43,120 THAT CAN E -- IF YOU HAVE A LARE 1329 00:50:43,120 --> 00:50:44,440 MEDICAL SCHOOL ON SITE THAT 1330 00:50:44,440 --> 00:50:45,200 WOULD BE ANOTHER PARTNERSHIP 1331 00:50:45,200 --> 00:50:50,320 THAT COULD WORK VERY WELL. 1332 00:50:50,320 --> 00:50:52,200 WE ARE CONDUCTING A WEBINAR CAN 1333 00:50:52,200 --> 00:50:54,360 YOU SEE THE APPLICATION WILL 1334 00:50:54,360 --> 00:50:55,720 ENCOURAGE THESE FOUR, THEY'RE 1335 00:50:55,720 --> 00:50:57,360 MUST SO THEY HAVE TO HAVE THESE 1336 00:50:57,360 --> 00:51:02,200 FOUR COMPONENTS AND FROM THERE 1337 00:51:02,200 --> 00:51:03,960 WILL BE CLINICAL SCHOOL ARREST 1338 00:51:03,960 --> 00:51:06,160 FOR THE PRIVATE SECTOR WHO WOULD 1339 00:51:06,160 --> 00:51:07,120 ENGAGE IN THE NATIONAL PRACTICE 1340 00:51:07,120 --> 00:51:10,480 BASED RESEARCH NETWORK WHO COULD 1341 00:51:10,480 --> 00:51:12,880 COME TO TERRY DICK INSON'S CALL 1342 00:51:12,880 --> 00:51:14,800 FOR ACTION IN VIRGINIA GET 1343 00:51:14,800 --> 00:51:16,040 INVOLVED IN COMMUNITY RESEARCH 1344 00:51:16,040 --> 00:51:17,560 AND PROVIDING THE EVIDENCE WE 1345 00:51:17,560 --> 00:51:19,920 NEED FOR POLICY REFORM AND THERE 1346 00:51:19,920 --> 00:51:27,120 ARE SO MANY OTHER MAGICAL FALL 1347 00:51:27,120 --> 00:51:30,000 OUTS. 1348 00:51:30,000 --> 00:51:33,680 DO THEIR MASTERS AND 1349 00:51:33,680 --> 00:51:34,600 WELL-INFORMED THIS IS MEANINGFUL 1350 00:51:34,600 --> 00:51:39,040 SCIENCE AND MAKE A DIFFERENCE TO 1351 00:51:39,040 --> 00:51:48,240 SPECIALTIES AS WELL. 1352 00:51:48,240 --> 00:51:49,800 HERE ARE THE NEW OPPORTUNITIES 1353 00:51:49,800 --> 00:51:51,000 THAT WE HAVE AVAILABLE AND ONE 1354 00:51:51,000 --> 00:51:55,240 TO DEVELOP A NEW SET OF 1355 00:51:55,240 --> 00:51:56,520 MATERIALS. 1356 00:51:56,520 --> 00:52:00,200 ORLANDO AND JAYS AN JUST RAN A 1357 00:52:00,200 --> 00:52:01,120 BRILLIANT THINK-TANK. 1358 00:52:01,120 --> 00:52:06,600 WE HAD PEOPLE WHO STANFORD AND 1359 00:52:06,600 --> 00:52:07,840 OTHER TO IN M AND LOOK WHAT 1360 00:52:07,840 --> 00:52:09,040 WE'RE DOING IN THE AREAS OF 1361 00:52:09,040 --> 00:52:10,000 DENTAL MATERIAL SCIENCE AND NOT 1362 00:52:10,000 --> 00:52:11,560 ONLY WITH THE FOCUS OF COMING UP 1363 00:52:11,560 --> 00:52:22,080 WITH THE REPLACEMENT ABOUT THE 1364 00:52:25,640 --> 00:52:27,480 USEFULNESS AS A RESTORATION THAT 1365 00:52:27,480 --> 00:52:31,760 LASTS LONG IS LOW COST IS 1366 00:52:31,760 --> 00:52:35,800 IMPORTANT AND WE HAVE MATERIAL 1367 00:52:35,800 --> 00:52:37,320 THAT TAKES ADVANTAGE OF HOST 1368 00:52:37,320 --> 00:52:40,320 RESPONSES AND CAN PREVENT THE 1369 00:52:40,320 --> 00:52:41,200 CURRENT DECAY, ET CETERA. 1370 00:52:41,200 --> 00:52:43,480 HERE IS ANOTHER ONE THAT IS 1371 00:52:43,480 --> 00:52:47,440 LOOKING AT DATA-DRIVEN TOO SO WE 1372 00:52:47,440 --> 00:52:48,880 CAN ACTUALLY MOVE BIO MATERIALS 1373 00:52:48,880 --> 00:52:52,640 DOWN FASTER AND THAT'S SUCH AN 1374 00:52:52,640 --> 00:52:54,480 EXCITING AREA, THIS WAS ACTUALLY 1375 00:52:54,480 --> 00:52:57,240 GOING TO BE THE TECHNICAL 1376 00:52:57,240 --> 00:52:59,720 WEBINAR THAT WOULD PROVIDE THE 1377 00:52:59,720 --> 00:53:01,280 ADDITIONAL INFORMATION THROUGH 1378 00:53:01,280 --> 00:53:03,640 Q&As SO THAT ANYONE INTERESTED 1379 00:53:03,640 --> 00:53:05,920 IN THIS AREA COULD BE WELL 1380 00:53:05,920 --> 00:53:07,440 POSITIONED TO SUCCEED. 1381 00:53:07,440 --> 00:53:11,880 I MENTIONED THIS BEFORE AS BEING 1382 00:53:11,880 --> 00:53:15,000 A HEALTH EQUITY PROGRAM DRIVEN 1383 00:53:15,000 --> 00:53:17,040 TOWARDS DIVERSE TRAININGS AND WE 1384 00:53:17,040 --> 00:53:23,920 WANT TO LOOK TO AN R25 AND IN 1385 00:53:23,920 --> 00:53:26,680 LOOKING AT SEX AS A BIOLOGICAL 1386 00:53:26,680 --> 00:53:31,600 VARIANT AND COMING UP AS 1387 00:53:31,600 --> 00:53:34,280 COMPETENCY AND CULTURAL 1388 00:53:34,280 --> 00:53:35,360 SENSITIVITY AND TREAT STRATEGIES 1389 00:53:35,360 --> 00:53:37,120 BASED ON THE BIOLOGY AND HOW 1390 00:53:37,120 --> 00:53:41,480 BEST TO DEVELOP THIS IN THE 1391 00:53:41,480 --> 00:53:41,720 FUTURE. 1392 00:53:41,720 --> 00:53:43,360 A FEW EXAMPLES THAT CAME FROM 1393 00:53:43,360 --> 00:53:45,080 THE RESEARCH REALLY DRAWING ON 1394 00:53:45,080 --> 00:53:50,120 THE SUCCESS STORIES OF OUR 1395 00:53:50,120 --> 00:53:52,120 FUNDED AWARDEES AND YOU SEE HOW 1396 00:53:52,120 --> 00:53:53,760 DIVERSE THIS PLATFORM IS AND SO 1397 00:53:53,760 --> 00:54:04,280 HERE IS A WONDERFUL EXAMPLE OF 1398 00:54:07,200 --> 00:54:08,480 OR ALKAN SER PAIN AND THOSE WHO 1399 00:54:08,480 --> 00:54:10,600 TREATED HEAD AND NECK YOU NOW 1400 00:54:10,600 --> 00:54:11,720 HOE THREAT EP TAG IS AND THERE'S 1401 00:54:11,720 --> 00:54:13,560 NOTHING LIKE IT AND NOTHING 1402 00:54:13,560 --> 00:54:14,920 REALLY SEEMS TO BE WORKING SO 1403 00:54:14,920 --> 00:54:20,200 THIS IS AN IMPORTANT MECHANISTIC 1404 00:54:20,200 --> 00:54:22,720 STUDY SO WE HAVE A COLLABORATION 1405 00:54:22,720 --> 00:54:26,720 WITH THE NATIONAL SCIENCE AND 1406 00:54:26,720 --> 00:54:27,120 TECHNOLOGY. 1407 00:54:27,120 --> 00:54:29,440 WHICH IS FEDERAL AGENCIES WE 1408 00:54:29,440 --> 00:54:32,920 COLLABORATE WITH LOOKING BIO COM 1409 00:54:32,920 --> 00:54:35,600 PAT BLEE TESTING IN A HOLISTIC 1410 00:54:35,600 --> 00:54:37,320 WAY AND WE ARE USING CELLS THERE 1411 00:54:37,320 --> 00:54:38,720 AND THEY DO SERVE THEIR PURPOSE 1412 00:54:38,720 --> 00:54:40,360 BECAUSE WE HAVE A PLATFORM THAT 1413 00:54:40,360 --> 00:54:44,440 IS STANDARDIZED AND UNIFORMLY 1414 00:54:44,440 --> 00:54:45,000 APPLIED. 1415 00:54:45,000 --> 00:54:46,600 LOOKING HERE AT SUPER STRUCTURES 1416 00:54:46,600 --> 00:54:50,520 OF WHAT ARE EXCITE SET OF 1417 00:54:50,520 --> 00:54:53,880 ROBOTIC-BASED OR DERIVED 1418 00:54:53,880 --> 00:54:54,560 RESEARCH FROM MICHELLE COONS' 1419 00:54:54,560 --> 00:54:55,680 GROUP AT THE UNIVERSITY OF 1420 00:54:55,680 --> 00:55:02,320 PENNSYLVANIA AND YOU CAN SEE 1421 00:55:02,320 --> 00:55:10,400 THAT USING SPECIFIC TOOLS AND 1422 00:55:10,400 --> 00:55:12,440 BEING ABLE TO REMOVE THEM 1423 00:55:12,440 --> 00:55:15,320 THROUGH NOT THROUGH A -- YOU USE 1424 00:55:15,320 --> 00:55:16,520 A BRUSH BUT IT'S USING A 1425 00:55:16,520 --> 00:55:18,200 DIFFERENT TECHNOLOGY THAT CAN BE 1426 00:55:18,200 --> 00:55:20,120 APPLIED AND TO OTHER CONDITIONS 1427 00:55:20,120 --> 00:55:22,560 FROM THE ORAL CAVITY. 1428 00:55:22,560 --> 00:55:26,520 IN THE SPACE OF OR ALKAN SER WE 1429 00:55:26,520 --> 00:55:28,400 HAVE NOW WHAT A STUDY THAT WAS 1430 00:55:28,400 --> 00:55:32,200 RECENTLY PUBLISHED IN JAN AND 1431 00:55:32,200 --> 00:55:33,960 LOOKING AT POST TREATMENT 1432 00:55:33,960 --> 00:55:35,240 SURVEILLANCE TIMING AND HOW 1433 00:55:35,240 --> 00:55:38,440 IMPORTANT THAT IS AND TO LOOK AT 1434 00:55:38,440 --> 00:55:39,760 THE LATEN SEE BETWEEN THE LAST 1435 00:55:39,760 --> 00:55:41,440 SURGERY OF THE LAST INTERVENTION 1436 00:55:41,440 --> 00:55:45,760 AND HOW THAT SHOULD BE STAGED IN 1437 00:55:45,760 --> 00:55:47,440 THROUGH THE LIFETIME OF THE 1438 00:55:47,440 --> 00:55:51,720 PATIENT AND LOOKING CAREFULLY AT 1439 00:55:51,720 --> 00:55:53,560 POST RADIO THERAPY CARRIES. 1440 00:55:53,560 --> 00:55:56,080 IT'S NOT JUST A DISEASE OF 1441 00:55:56,080 --> 00:55:57,280 CHILDHOOD, IT CAN COME UP ANY 1442 00:55:57,280 --> 00:55:59,400 TIME MANY OF IT'S A LIFESPAN 1443 00:55:59,400 --> 00:56:00,800 LONG ONE AND THE AGING 1444 00:56:00,800 --> 00:56:02,000 POPULATION FOR THOSE WHO 1445 00:56:02,000 --> 00:56:04,120 RECEIVED RADIATION THERAPY, FOR 1446 00:56:04,120 --> 00:56:05,640 CANCERS IT'S VERY THREATENING 1447 00:56:05,640 --> 00:56:07,320 WHEN DUE HAVE THAT PROTECTIVE 1448 00:56:07,320 --> 00:56:11,080 INFLUENCE AND SO THIS IS LOOKING 1449 00:56:11,080 --> 00:56:13,680 AT POST RADIO THERAPY 1450 00:56:13,680 --> 00:56:16,280 MAINTENANCE OF MONITORING AND 1451 00:56:16,280 --> 00:56:20,240 WHEN YOU HAVE A DEFICIENT 1452 00:56:20,240 --> 00:56:21,520 SALIVARY FLOW AND I'M GLAD THAT 1453 00:56:21,520 --> 00:56:23,920 WE HAVE REMOVING TOWARDS MORE 1454 00:56:23,920 --> 00:56:26,920 DIGITAL WORKFLOWS FOR 1455 00:56:26,920 --> 00:56:28,480 RECONSTRUCTING BONE USING 1456 00:56:28,480 --> 00:56:30,720 DIFFERENT SCAFFOLD IN THIS CASE 1457 00:56:30,720 --> 00:56:36,000 IT WAS PHOSPHATE AND OSTEO INC 1458 00:56:36,000 --> 00:56:40,440 PUBLISHED BY DONEL KIGLER AND 1459 00:56:40,440 --> 00:56:41,840 THEY HAVE APPLICATIONS FOR WHAT 1460 00:56:41,840 --> 00:56:47,000 WE DO IN DENTISTRY. 1461 00:56:47,000 --> 00:56:48,280 I WAS VERY STRUCK BY THE LEVEL 1462 00:56:48,280 --> 00:56:50,120 OF SUPPORT IN STATES LIKE NEW 1463 00:56:50,120 --> 00:56:51,640 YORK AND IN CALIFORNIA FOR THE 1464 00:56:51,640 --> 00:56:53,080 SPECIAL NEEDS' POPULATION. 1465 00:56:53,080 --> 00:56:57,200 THOSE WHO ARE INTELLECTUALLY OR 1466 00:56:57,200 --> 00:56:58,240 MENTALLY DISABLED. 1467 00:56:58,240 --> 00:57:00,600 THERE'S A WHOLE ARRAY OF SPECIAL 1468 00:57:00,600 --> 00:57:02,600 NEEDS' PATIENTS WHERE YOU HAVE 1469 00:57:02,600 --> 00:57:04,200 CONDITIONS OF MULTIPLE 1470 00:57:04,200 --> 00:57:06,400 SCLEROSIS, CEREBRAL PALSY AND 1471 00:57:06,400 --> 00:57:08,000 CHILDREN THAT PARTICULARLY IT'S 1472 00:57:08,000 --> 00:57:09,760 CHALLENGING AND IT'S NOT EASY TO 1473 00:57:09,760 --> 00:57:13,640 ACCESS CARE AND VERY OFTEN THE 1474 00:57:13,640 --> 00:57:14,920 CARE OR CARE TAKERS ARE NOT 1475 00:57:14,920 --> 00:57:16,800 TRAINED IN ORAL HEALTH NEEDS AND 1476 00:57:16,800 --> 00:57:18,080 THEY'RE MODULES BEING DEVELOPED 1477 00:57:18,080 --> 00:57:19,520 AND IT'S A HIGH LEVEL OF 1478 00:57:19,520 --> 00:57:21,160 TURNOVER AND SO I WAS VERY HAPPY 1479 00:57:21,160 --> 00:57:25,160 TO SEE THAT WE HAVE THE STUDY 1480 00:57:25,160 --> 00:57:26,480 OUT THERE TALKING ABOUT HOW 1481 00:57:26,480 --> 00:57:30,520 AUTISTIC AND NON AUTISTIC LATINO 1482 00:57:30,520 --> 00:57:38,640 CHILDREN RESPOND TO ORAL HYGIENE 1483 00:57:38,640 --> 00:57:39,920 EDUCATION AND WE ARE OPEN TO THE 1484 00:57:39,920 --> 00:57:41,320 NEEDS AND APPLICATIONS THAT YOU 1485 00:57:41,320 --> 00:57:42,920 WILL BRING TO COUNCIL FOR OUR 1486 00:57:42,920 --> 00:57:43,200 ATTENTION. 1487 00:57:43,200 --> 00:57:45,960 JUST TO REMIND YOU THAT 1488 00:57:45,960 --> 00:57:48,800 SEPTEMBER IS WHEN YOUR SKULL 1489 00:57:48,800 --> 00:57:50,240 FUSES TO ARTICLE AND YOUR BRAIN 1490 00:57:50,240 --> 00:57:51,040 IS GROWING AT THE SAME TIME AND 1491 00:57:51,040 --> 00:57:52,600 YOU HAVE CHILDREN BORN WITH THIS 1492 00:57:52,600 --> 00:57:55,200 DUE TO SINGLE LOSS OF FUNCTION 1493 00:57:55,200 --> 00:57:58,720 OR GAIN OF FUNCTION MUTATIONS IN 1494 00:57:58,720 --> 00:58:01,600 TWISTS OR FJRF2 AND IT'S 1495 00:58:01,600 --> 00:58:02,400 THREATENING BECAUSE THESE KIDS 1496 00:58:02,400 --> 00:58:04,680 HAVE TO UNDERGO SERIES OF 1497 00:58:04,680 --> 00:58:07,040 SURGERIES AND THEY ARE TYPICALLY 1498 00:58:07,040 --> 00:58:09,600 IT'S OBVIOUSLY EXPOSING THE 1499 00:58:09,600 --> 00:58:10,960 BRAIN AND COMING THROUGH THE 1500 00:58:10,960 --> 00:58:15,040 SKULL AND REPOSITIONING THE CAL 1501 00:58:15,040 --> 00:58:20,560 VAR WHY SOCALLIA AND WE NEED TON 1502 00:58:20,560 --> 00:58:22,840 THE FUTURE TO DEVELOP IF IT'S A 1503 00:58:22,840 --> 00:58:32,800 SINGLE GENE BASE AND TO KICK A 1504 00:58:32,800 --> 00:58:34,840 SIGNALING PATHWAY INTO ACTION TO 1505 00:58:34,840 --> 00:58:36,360 PREVENT THIS FROM HAPPENING. 1506 00:58:36,360 --> 00:58:37,840 YOU'VE HEARD FROM LYNN, OF 1507 00:58:37,840 --> 00:58:42,080 COURSE, WHO IS RUNNING COUNCIL 1508 00:58:42,080 --> 00:58:44,800 AND ANISA BROWN, JUST FABULOUS 1509 00:58:44,800 --> 00:58:46,440 TO HAVE HER ON BOARD WITH HER 1510 00:58:46,440 --> 00:58:48,240 EXPERTISE AND WISDOM AND 1511 00:58:48,240 --> 00:58:56,920 MATURITY BUT BELINDA HAUSER JURY 1512 00:58:56,920 --> 00:58:58,720 ENERGY AND CARE THROUGH THESE 1513 00:58:58,720 --> 00:59:01,080 PROGRAMS HAS BENEFITED NIDCR. 1514 00:59:01,080 --> 00:59:03,520 A SHOUT OUT TO AADOCR WHO IS ONE 1515 00:59:03,520 --> 00:59:07,320 OF OUR GRANTEES FOR THIS MIND 1516 00:59:07,320 --> 00:59:12,720 THE FUTURE, THE GRANTEE ALONG 1517 00:59:12,720 --> 00:59:14,960 WITH DAVID DRAKE AND EFFIE FROM 1518 00:59:14,960 --> 00:59:17,120 CONNECTICUT AS CHIEF OR PIs 1519 00:59:17,120 --> 00:59:19,800 AND RECRUIT INTERESTING ACROSS 1520 00:59:19,800 --> 00:59:22,600 OUR COUNTRY, EARLY-STAGE FACULTY 1521 00:59:22,600 --> 00:59:24,120 MEMBERS, SOME HAVE FORMAL 1522 00:59:24,120 --> 00:59:24,920 RESEARCH EXPERIENCE AND SOME 1523 00:59:24,920 --> 00:59:27,040 DON'T BUT THEY'RE OUT THERE AND 1524 00:59:27,040 --> 00:59:34,560 THEY GET MEN FORW MENTORED AND % 1525 00:59:34,560 --> 00:59:35,680 HAVE AN NIH GRANT. 1526 00:59:35,680 --> 00:59:37,080 SO VERY PLEASED WITH THIS OUT 1527 00:59:37,080 --> 00:59:41,600 AND WELCOME TO CLASS OF 2022-23. 1528 00:59:41,600 --> 00:59:44,560 YOU CAN SEE THESE ARE OUR FUTURE 1529 00:59:44,560 --> 00:59:45,920 ORAL HEALTH SCIENCE AND I WANT 1530 00:59:45,920 --> 00:59:49,160 EACH OF YOU TO KNOW YOUR VALUED 1531 00:59:49,160 --> 00:59:50,200 AND YOU ARE TREASURED ACTUALLY 1532 00:59:50,200 --> 00:59:51,960 AND YOU ARE MOST PRECIOUS 1533 00:59:51,960 --> 00:59:53,880 INVESTMENTS AND WE HOPE YOU STAY 1534 00:59:53,880 --> 00:59:58,520 TRUE TO COURSE AND KEEP ON YOUR 1535 00:59:58,520 --> 00:59:59,640 PATH TO SUCCESS. 1536 00:59:59,640 --> 01:00:01,160 THIS IS A SLIDE THAT DESCRIBES 1537 01:00:01,160 --> 01:00:03,520 THE PROGRAMS THAT BELINDA 1538 01:00:03,520 --> 01:00:06,280 MANAGES FOR THE DIVISION OF 1539 01:00:06,280 --> 01:00:07,120 INTRAMURAL RESEARCH. 1540 01:00:07,120 --> 01:00:09,560 THERE ARE SUMMER INTERNSHIP 1541 01:00:09,560 --> 01:00:11,080 PROGRAMS AND IT ENCOURAGES 1542 01:00:11,080 --> 01:00:11,440 STUDENTS. 1543 01:00:11,440 --> 01:00:12,280 YOU WOULD BE SURPRISED. 1544 01:00:12,280 --> 01:00:14,160 THEY TOOK A BREAK IN THE SUMMER 1545 01:00:14,160 --> 01:00:16,640 OR CAME FROM A YEAR TO NIDCR, IT 1546 01:00:16,640 --> 01:00:19,120 CAN BE TRANSFORMATIVE FOR THEIR 1547 01:00:19,120 --> 01:00:19,480 LIVES. 1548 01:00:19,480 --> 01:00:25,440 BECAUSE THEY'RE IMMERSED IN A 1549 01:00:25,440 --> 01:00:28,400 INTELLECTUAL RIGOROUS 1550 01:00:28,400 --> 01:00:28,720 ENVIRONMENT. 1551 01:00:28,720 --> 01:00:30,200 YOU CAN SEE IT GOES ALL THE WAY 1552 01:00:30,200 --> 01:00:33,320 TO CARE WARDS, CAREER TRANSITION 1553 01:00:33,320 --> 01:00:33,680 WARDS. 1554 01:00:33,680 --> 01:00:35,320 HERE IS OUR GROUP OF SUMMER 1555 01:00:35,320 --> 01:00:37,080 TRAINEES AND I HAD A CHANCE TO 1556 01:00:37,080 --> 01:00:38,160 VIEW THEIR POSTERS. 1557 01:00:38,160 --> 01:00:40,280 EACH ONE IS BRIGHT AND ENGAGING. 1558 01:00:40,280 --> 01:00:44,080 SOME ARE DDSs AND SOME ARE 1559 01:00:44,080 --> 01:00:45,440 DDP-PH.D AND SOME ARE PRE DICK 1560 01:00:45,440 --> 01:00:48,800 DOCTORAL. 1561 01:00:48,800 --> 01:00:51,400 OUR NEW PROGRAM ON MENTORING AND 1562 01:00:51,400 --> 01:00:53,160 DIVERSITY HAS YIELDED A REALLY A 1563 01:00:53,160 --> 01:00:55,840 STRONG SET OF FELLOWS WHO ARE 1564 01:00:55,840 --> 01:01:02,280 NOVAK TIVE IN LABS AND IN THE 1565 01:01:02,280 --> 01:01:04,920 INTRAMURAL PROGRAM AND THANK YOU 1566 01:01:04,920 --> 01:01:15,280 FOR CARING FOR THEM. 1567 01:01:17,160 --> 01:01:19,440 WE ARE FOCUSED ON TRAINING THAT 1568 01:01:19,440 --> 01:01:20,720 DELIVER DENTAL PUBLIC-HEALTH 1569 01:01:20,720 --> 01:01:22,080 SPECIFIC KNOWLEDGE BECAUSE OUR 1570 01:01:22,080 --> 01:01:26,560 TRAINEES ARE ENCOURAGED TO HAVE 1571 01:01:26,560 --> 01:01:28,560 MPHs THEY COME WITH 1572 01:01:28,560 --> 01:01:29,760 PUBLIC-HEALTH IN GENERAL AND 1573 01:01:29,760 --> 01:01:31,400 THEY'RE GIVEN ORAL 1574 01:01:31,400 --> 01:01:32,240 HEALTH-SPECIFIC INFORMATION AND 1575 01:01:32,240 --> 01:01:35,320 THEY ROTATE THROUGH CDC AND HRSA 1576 01:01:35,320 --> 01:01:37,800 AND VIRGINIA STATE DENTAL IN ALL 1577 01:01:37,800 --> 01:01:39,360 THESE NON PROFITS AVAILABLE SO 1578 01:01:39,360 --> 01:01:43,520 THEY GET A CHANCE TO EXPERIENCE 1579 01:01:43,520 --> 01:01:44,840 THAT SIDE AND THEY'LL DO TWO 1580 01:01:44,840 --> 01:01:47,840 YEARS OF A POSTDOC BASED 1581 01:01:47,840 --> 01:01:49,320 RESEARCH WITH A ANOTHER 1582 01:01:49,320 --> 01:01:50,520 INSTITUTE OR OR OWN DEALING WITH 1583 01:01:50,520 --> 01:01:53,640 THE EMERGING AREAS OF NEED FOR 1584 01:01:53,640 --> 01:01:54,680 WHICH GOUGH NEED DATA AND WE DO 1585 01:01:54,680 --> 01:01:58,360 NEED THE EVIDENCE AND WHETHER 1586 01:01:58,360 --> 01:02:02,800 IT'S CMSs OR WE DO NEED THESE 1587 01:02:02,800 --> 01:02:05,320 INDIVIDUALS TO GO OUT INTO THE 1588 01:02:05,320 --> 01:02:09,080 WORLD AS THOUGHT LEADERS FOR 1589 01:02:09,080 --> 01:02:09,840 PUBLIC-HEALTH. 1590 01:02:09,840 --> 01:02:11,680 DENTISTRY OR ORAL HEALTH AND I 1591 01:02:11,680 --> 01:02:13,080 WANTED THIS TO ACTUALLY SERVE AS 1592 01:02:13,080 --> 01:02:16,840 THE MODEL FOR OTHER 1593 01:02:16,840 --> 01:02:25,760 PUBLIC-HEALTH PROGRAMS -- IT'S 1594 01:02:25,760 --> 01:02:28,040 FINE BUT WE DO NEED TO KNOW, TO 1595 01:02:28,040 --> 01:02:30,160 UNDERSTAND THAT OUR ROLE IN 1596 01:02:30,160 --> 01:02:31,720 PUBLIC-HEALTH IS SO IMPORTANT 1597 01:02:31,720 --> 01:02:33,040 FOR OUR NATION. 1598 01:02:33,040 --> 01:02:36,320 SO I'M HOPING THAT THIS SERVES 1599 01:02:36,320 --> 01:02:43,280 AS A MODEL OF SUCCESS. 1600 01:02:43,280 --> 01:02:45,840 WE ARE PREPARING TO CELEBRATE 1601 01:02:45,840 --> 01:02:49,640 OUR 75th, NO FLASHY GALAS, 1602 01:02:49,640 --> 01:02:53,280 JUST RECOGNITION OF WHO WE ARE, 1603 01:02:53,280 --> 01:02:56,120 WHY WE WERE CREATED 75 YEARS AGO 1604 01:02:56,120 --> 01:03:01,720 BY HARRY TRUEMAN, DRIVEN BY THE 1605 01:03:01,720 --> 01:03:04,560 NEED TO TAKE CARE APPEARING TO 1606 01:03:04,560 --> 01:03:05,280 RAVAGE THE MOUTHS OF YOUNG MEN 1607 01:03:05,280 --> 01:03:07,280 WHO FAILED TO GET RECRUITED TO 1608 01:03:07,280 --> 01:03:09,080 THE CAR AND HE FELT THE NEED FOR 1609 01:03:09,080 --> 01:03:11,120 AN INSTITUTE THAT WOULD CARE 1610 01:03:11,120 --> 01:03:12,520 ABOUT THAT PUBLIC-HEALTH CRISIS 1611 01:03:12,520 --> 01:03:14,040 IN HIS TERMS. 1612 01:03:14,040 --> 01:03:16,360 WE'VE STAYED TRUE TO THAT COURSE 1613 01:03:16,360 --> 01:03:17,920 IN 75 YEARS AND NOW WE LOOK TO 1614 01:03:17,920 --> 01:03:19,320 THE FUTURE SO THE WHOLE 1615 01:03:19,320 --> 01:03:20,840 CELEBRATION IS GOING TO BE 1616 01:03:20,840 --> 01:03:22,840 FUTURISTIC, IT'S GOING TO BE, 1617 01:03:22,840 --> 01:03:24,880 WHAT DO WE WANT TO BE 25 YEARS 1618 01:03:24,880 --> 01:03:25,720 FROM NOW? 1619 01:03:25,720 --> 01:03:27,280 WHAT DO WE WANT ANOTHER REPORT 1620 01:03:27,280 --> 01:03:29,280 ON THE ORAL HEALTH IN AMERICA TO 1621 01:03:29,280 --> 01:03:30,080 TELL US? 1622 01:03:30,080 --> 01:03:32,160 THAT WE MADE PROGRESS? 1623 01:03:32,160 --> 01:03:33,360 SO WE'RE DOING ALL OF THESE 1624 01:03:33,360 --> 01:03:35,200 THINGS AND IT'S JUST A SKETCH ON 1625 01:03:35,200 --> 01:03:36,800 ALL THE DETAILS AND UNFOLD AND 1626 01:03:36,800 --> 01:03:40,280 I'M SO GRATEFUL THAT IT IS A 1627 01:03:40,280 --> 01:03:40,920 TEAM-APPROACH. 1628 01:03:40,920 --> 01:03:42,160 I JUST SAT BACK AND LET THE 1629 01:03:42,160 --> 01:03:44,280 MAGIC UNFOLD AND WE'VE GOT SAY 1630 01:03:44,280 --> 01:03:50,200 PAST DIRECTORS, WE HAVE OTHER 1631 01:03:50,200 --> 01:03:52,400 LEADERS OF NIDCR AND NIH 1632 01:03:52,400 --> 01:03:56,200 PARTICIPATING WITH SUCH 1633 01:03:56,200 --> 01:03:56,440 EXPERTISE. 1634 01:03:56,440 --> 01:03:57,440 JIM LIPTON, I'M HAPPY TO HAVE 1635 01:03:57,440 --> 01:04:00,560 THEM AND TO HAVE OUR CURRENT 1636 01:04:00,560 --> 01:04:02,600 STAFFERS, WHICH IS PLANNING 1637 01:04:02,600 --> 01:04:03,000 THIS. 1638 01:04:03,000 --> 01:04:05,760 WE'LL KICK IT OFF IN '23 IN 1639 01:04:05,760 --> 01:04:06,840 PORTLAND BECAUSE THAT'S THE 1640 01:04:06,840 --> 01:04:08,120 FORUM WE HAVE AVAILABLE WITH A 1641 01:04:08,120 --> 01:04:10,120 NICE SYMPOSIUM THAT LOOKS AT THE 1642 01:04:10,120 --> 01:04:11,560 FUTURE AND IT'S GOING TO BE 1643 01:04:11,560 --> 01:04:13,280 DELIVERED BY OUR PAST DIRECTORS 1644 01:04:13,280 --> 01:04:16,880 AND MYSELF. 1645 01:04:16,880 --> 01:04:18,400 THEN WE'LL HAVE -- WE'LL KICKOFF 1646 01:04:18,400 --> 01:04:20,640 THE YEAR WITH A SYMPOSIUM AGAIN 1647 01:04:20,640 --> 01:04:24,080 HOPEFULLY WITH ONE OF OUR NEW 1648 01:04:24,080 --> 01:04:26,600 NOBEL LAUREATES AND LARRY 1649 01:04:26,600 --> 01:04:28,240 MCCAULEY IS A SPEAKER FOR THAT 1650 01:04:28,240 --> 01:04:30,120 ONE AND JUST RECOGNIZING OUR 1651 01:04:30,120 --> 01:04:32,520 STAFFERS FOR THEIR DISTINGUISHED 1652 01:04:32,520 --> 01:04:34,080 SERVICES AND THEN THIS AS I 1653 01:04:34,080 --> 01:04:37,000 MENTIONED BEFORE, A DEDICATED 1654 01:04:37,000 --> 01:04:40,640 SEMINAR OR SYMPOSIUM TO 1655 01:04:40,640 --> 01:04:41,880 CELEBRATE 25 YEARS OF RESEARCH 1656 01:04:41,880 --> 01:04:45,000 THAT HAS COME FROM THE MIKE 1657 01:04:45,000 --> 01:04:46,120 COLLINS' GROUP. 1658 01:04:46,120 --> 01:04:47,600 IT'S HELD ANOTHER TIME, TRAINING 1659 01:04:47,600 --> 01:04:49,760 AND CAREER DEVELOPMENT WILL BE 1660 01:04:49,760 --> 01:04:50,800 THE FLAGSHIP ACTIVITY BECAUSE 1661 01:04:50,800 --> 01:04:53,200 THAT IS THE FUTURE. 1662 01:04:53,200 --> 01:04:54,840 350 ODD TRAINEES WILL COME TO 1663 01:04:54,840 --> 01:04:57,120 OUR CAMPUS WITH THEIR MENTORS 1664 01:04:57,120 --> 01:04:58,760 HOPEFULLY AND DIRECTORS OF 1665 01:04:58,760 --> 01:05:00,240 PROGRAMS AND PERHAPS DEANS TO 1666 01:05:00,240 --> 01:05:04,080 LISTEN TO ENGAGE AND TO SHOWCASE 1667 01:05:04,080 --> 01:05:05,520 THE SCIENCE AND SUCCESS AND 1668 01:05:05,520 --> 01:05:07,080 WE'RE PLANNING THAT WITH A LOT 1669 01:05:07,080 --> 01:05:09,560 OF DEDICATION AND RESOLVE SO 1670 01:05:09,560 --> 01:05:12,720 THAT IS THE HIGHLIGHT AND THE 1671 01:05:12,720 --> 01:05:15,440 FLAGSHIP AND WE'LL END THE YEAR 1672 01:05:15,440 --> 01:05:17,760 WITH THE SYMPOSIUM IN NEW 1673 01:05:17,760 --> 01:05:22,080 ORLEANS AND NOW THERE ARE THEY 1674 01:05:22,080 --> 01:05:24,120 WILL FOLLOW THE THEMES FOR THE 1675 01:05:24,120 --> 01:05:26,040 INFORM AND ALWAYS ATTRACTED TO 1676 01:05:26,040 --> 01:05:27,440 THE SCIENCE THAT WE PRODUCE AND 1677 01:05:27,440 --> 01:05:30,520 THE SCIENCE THAT WE HOPE TO 1678 01:05:30,520 --> 01:05:31,960 PRODUCE SO WHERE THE PROGRESS 1679 01:05:31,960 --> 01:05:33,440 HAS BEEN MADE WHETHER THE 1680 01:05:33,440 --> 01:05:34,840 CHALLENGES LIE AND OUR PATH 1681 01:05:34,840 --> 01:05:36,160 FORWARD AND THAT WOULD BE THE 1682 01:05:36,160 --> 01:05:42,480 THEME FOR THAT PARTICULAR SET OF 1683 01:05:42,480 --> 01:05:44,040 VINIERS AND WE'LL HEAR FROM 1684 01:05:44,040 --> 01:05:44,680 COUNCIL MEMBERS THEIR THOUGHTS 1685 01:05:44,680 --> 01:05:47,560 OF COMING UP WITH INTEGRATIVE 1686 01:05:47,560 --> 01:05:49,200 THEMES OF OF EDITORIALS THAT GO 1687 01:05:49,200 --> 01:05:51,200 OUT TO OUR STAKEHOLDER GROUPS, 1688 01:05:51,200 --> 01:05:53,560 KIND OF SAYING, WELCOME, COME ON 1689 01:05:53,560 --> 01:05:55,720 IN AND HERE IS THE PARTNERSHIP 1690 01:05:55,720 --> 01:05:56,960 THAT BEGINS AND I MEAN IT'S 1691 01:05:56,960 --> 01:05:58,360 ALREADY THERE BUT IT WOULD BE 1692 01:05:58,360 --> 01:05:59,920 ONE STRENGTHENING IT AND MAKING 1693 01:05:59,920 --> 01:06:01,720 IT APPLICABLE TO THE FUTURE. 1694 01:06:01,720 --> 01:06:06,200 SO HERE I AM, NOT HAVING DONE 1695 01:06:06,200 --> 01:06:09,880 VERY MUCH MORE THAN RELY ON THIS 1696 01:06:09,880 --> 01:06:10,960 AMAZING TEAM OF STAFF WHOSE 1697 01:06:10,960 --> 01:06:12,440 DEDICATION AND COMMITMENT 1698 01:06:12,440 --> 01:06:14,160 THROUGH THIS HARD TIMES HAS BEEN 1699 01:06:14,160 --> 01:06:15,560 REALLY OUTSTANDING. 1700 01:06:15,560 --> 01:06:17,840 FOR ME MAKING IT TRULY AN HONOR 1701 01:06:17,840 --> 01:06:19,400 AND A PRIVILEGE TO BE HERE 1702 01:06:19,400 --> 01:06:22,440 EVERYDAY, LOOKING FORWARD TO 25 1703 01:06:22,440 --> 01:06:23,760 YEARS, LOOKING FORWARD TO NEXT 1704 01:06:23,760 --> 01:06:25,120 YEAR AND THE NEXT MONTH WITH A 1705 01:06:25,120 --> 01:06:28,760 LOT OF ENTHUSIASM AND CARE FOR 1706 01:06:28,760 --> 01:06:30,520 THIS INSTITUTE AND ALL THAT WE 1707 01:06:30,520 --> 01:06:31,960 ARE RESPONSIBLE FOR. 1708 01:06:31,960 --> 01:06:37,680 SO, DO STAY ENGAGE, TALK TO YOUR 1709 01:06:37,680 --> 01:06:39,440 INDIVIDUAL CONSTITUENTS AND YOUR 1710 01:06:39,440 --> 01:06:41,360 ECOSYSTEM AND HELP THEM ACTUALLY 1711 01:06:41,360 --> 01:06:43,520 COME ON BOARD BY LISTENING TO 1712 01:06:43,520 --> 01:06:45,440 THIS, LISTENING TO COUNCIL 1713 01:06:45,440 --> 01:06:46,360 RECORDINGS AND PARTICIPATING 1714 01:06:46,360 --> 01:06:48,280 MORE ACTIVELY. 1715 01:06:48,280 --> 01:06:49,560 BECAUSE WE NEED YOU. 1716 01:06:49,560 --> 01:06:51,360 WE CAN'T JUST DO THIS ON OUR 1717 01:06:51,360 --> 01:06:51,520 OWN. 1718 01:06:51,520 --> 01:06:54,200 THANK YOU, AGAIN, AND NOW IT'S 1719 01:06:54,200 --> 01:06:57,720 MY GREAT PLEASURE TO INTRODUCE 1720 01:06:57,720 --> 01:06:59,760 AMAZING SLATE OF SPEAKERS. 1721 01:06:59,760 --> 01:07:04,400 BOB CARTER, WHO FOR ME WAS A 1722 01:07:04,400 --> 01:07:07,960 FONT OF VIS D WISDOM. 1723 01:07:07,960 --> 01:07:13,400 WE WORKED CLOSELY IN SUITE OF 1724 01:07:13,400 --> 01:07:15,000 OUR MUSS CUE LOWSKELETAL AND HE 1725 01:07:15,000 --> 01:07:25,560 HAS REALLY WEALTH OF EXPERIENCEN 1726 01:07:26,560 --> 01:07:28,480 THE AREA OF AUTOIMMUNE DISORDERS 1727 01:07:28,480 --> 01:07:30,920 THAT WE ARE BENEFITING FROM SO 1728 01:07:30,920 --> 01:07:33,560 BOB WILL TALK TO US ABOUT 1729 01:07:33,560 --> 01:07:35,600 LESSONS LEARNED, FROM AN 1730 01:07:35,600 --> 01:07:37,880 INITIATIVE CALLED BACKPACK WHICH 1731 01:07:37,880 --> 01:07:40,400 IS BROAD BACK PAIN WHICH 1732 01:07:40,400 --> 01:07:42,200 UNDOUBTEDLY ALL OF US ARE 1733 01:07:42,200 --> 01:07:44,280 SUFFERING FROM THROUGH THESE 1734 01:07:44,280 --> 01:07:46,920 ZOOM SESSIONS AND MANY OF THE 1735 01:07:46,920 --> 01:07:48,680 PIECES OF ADVICE HE CAN SHARE 1736 01:07:48,680 --> 01:07:49,800 WITH US AND WORE GRATEFUL TO 1737 01:07:49,800 --> 01:07:52,000 HAVE YOU HERE. 1738 01:07:52,000 --> 01:07:55,160 WELCOME BACK, AXEL. 1739 01:07:55,160 --> 01:07:56,680 YOU HEADING THIS SPECIAL WORKING 1740 01:07:56,680 --> 01:07:58,680 GROUP FOR US IS A VERY IMPORTANT 1741 01:07:58,680 --> 01:08:00,200 CONTRIBUTION AND IT'S AN AREA 1742 01:08:00,200 --> 01:08:01,960 THAT WE ARE DEEPLY COMMITTED TO 1743 01:08:01,960 --> 01:08:04,320 AND IT'S AN EXPENSIVE 1744 01:08:04,320 --> 01:08:04,640 INVESTMENT. 1745 01:08:04,640 --> 01:08:06,240 DATA SCIENCE SO WE WANT TO BE 1746 01:08:06,240 --> 01:08:07,760 WISE AND STRATEGIC AND WHAT YOU 1747 01:08:07,760 --> 01:08:09,680 SHARE WITH US THROUGH THE YEAR, 1748 01:08:09,680 --> 01:08:11,360 ON PROGRESS MADE BY YOUR GROUP 1749 01:08:11,360 --> 01:08:15,840 IS GOING TO BE CRITICAL IN HOW 1750 01:08:15,840 --> 01:08:18,920 WE SHAPE THE OFFICE LED BY JOHN 1751 01:08:18,920 --> 01:08:22,400 PRUGH AND Dr. LIEU WANG AT 1752 01:08:22,400 --> 01:08:22,600 NIDCR. 1753 01:08:22,600 --> 01:08:24,680 WE HAVE DANA GRAVES WHO IS SUCH 1754 01:08:24,680 --> 01:08:27,280 A FAMILIAR FACE AND EXPERT FOR 1755 01:08:27,280 --> 01:08:28,400 OUR FIELD. 1756 01:08:28,400 --> 01:08:31,200 BEING A ROLE MODEL, MENTOR AND 1757 01:08:31,200 --> 01:08:33,480 LEADER FOR ORAL HEALTH RESEARCH 1758 01:08:33,480 --> 01:08:36,240 BASED AT PENN AND DANA IS 1759 01:08:36,240 --> 01:08:37,400 HEADING THE WORKING GROUP 1760 01:08:37,400 --> 01:08:39,160 LOOKING AT HOW WE DO THINGS 1761 01:08:39,160 --> 01:08:40,560 DIFFERENTLY IN TRAINING OUR 1762 01:08:40,560 --> 01:08:41,640 CLINICIAN SCIENTISTS FOR THE 1763 01:08:41,640 --> 01:08:44,960 FUTURE AND LOOKING AT WHETHER 1764 01:08:44,960 --> 01:08:48,400 THE DDS DHB IS GIVING US THE 1765 01:08:48,400 --> 01:08:49,360 RETURN OF INVESTMENT AND IF NOT 1766 01:08:49,360 --> 01:08:50,800 WHAT WE CAN DO TO SHAPE IT FOR 1767 01:08:50,800 --> 01:08:51,280 THE FUTURE. 1768 01:08:51,280 --> 01:08:54,800 SO DANA, THANK YOU FOR ACCEPTING 1769 01:08:54,800 --> 01:08:55,240 THAT. 1770 01:08:55,240 --> 01:08:57,440 AND THEN NOT BY ANY MEANS THE 1771 01:08:57,440 --> 01:09:02,720 LEAST IS BRUCE DONOFF WHO I HAVE 1772 01:09:02,720 --> 01:09:05,080 KNOWN FOR YEARS AND I HAVE NOT 1773 01:09:05,080 --> 01:09:06,720 MET ANY INDIVIDUAL WHO CARES AS 1774 01:09:06,720 --> 01:09:09,200 DEEPLY ABOUT OUR PROFESSION AS 1775 01:09:09,200 --> 01:09:11,440 BRUCE, ABOUT ORAL HEALTHCARE FOR 1776 01:09:11,440 --> 01:09:11,600 ALL. 1777 01:09:11,600 --> 01:09:12,720 IT WAS BRUTE THAT GOT ME SET UP 1778 01:09:12,720 --> 01:09:14,600 FOR THE NEW ENGLAND JOURNAL OF 1779 01:09:14,600 --> 01:09:16,440 MEDICINE PERSPECTIVE ARTICLE AND 1780 01:09:16,440 --> 01:09:18,560 HE IS IN ADDITION TO SERVING AS 1781 01:09:18,560 --> 01:09:20,720 DEAN OF HARVARD, THE LONGEST 1782 01:09:20,720 --> 01:09:22,000 STANDING DEAN FOR 28 OR 30 1783 01:09:22,000 --> 01:09:24,160 YEARS, BRUCE HAS BEEN A PERSON 1784 01:09:24,160 --> 01:09:26,640 OF MENTOR AND FRIEND TO ME OVER 1785 01:09:26,640 --> 01:09:29,880 THE YEARS AND IS VERY KEEN ON 1786 01:09:29,880 --> 01:09:30,920 SHARING HIS THOUGHTS THAT ARE 1787 01:09:30,920 --> 01:09:33,080 GROWN OUT OF HIS YEARS OF 1788 01:09:33,080 --> 01:09:34,480 INTERACTING WITH THE HARVARD 1789 01:09:34,480 --> 01:09:37,680 SCHOOL OF MEDICINE AS AN ORAL 1790 01:09:37,680 --> 01:09:38,960 SURGEON AND WE HOPE TO LEARN 1791 01:09:38,960 --> 01:09:41,920 FROM YOU, BRUCE, ABOUT THIS -- 1792 01:09:41,920 --> 01:09:43,840 IT MAY SOUND RADICAL TO COME BUT 1793 01:09:43,840 --> 01:09:45,720 IT'S A WISE PLATFORM TO BE ON. 1794 01:09:45,720 --> 01:09:47,160 SO THANK YOU FOR BEING HERE AND 1795 01:09:47,160 --> 01:09:50,840 ALL OF YOU AND I WILL NOW END BY 1796 01:09:50,840 --> 01:09:57,280 GETTING OUT OF MY POWERPOINT. 1797 01:09:57,280 --> 01:09:58,000 SHARE SCREEN. 1798 01:09:58,000 --> 01:09:58,600 THANK YOU. 1799 01:09:58,600 --> 01:09:59,800 ARE THERE ANY QUESTIONS? 1800 01:09:59,800 --> 01:10:03,240 THERE ARE SOME. 1801 01:10:03,240 --> 01:10:04,080 THAT'S NICE. 1802 01:10:04,080 --> 01:10:07,200 IT WAS JUST MANY THANK YOUS. 1803 01:10:07,200 --> 01:10:08,920 IF THERE ARE QUESTIONS, FEEL 1804 01:10:08,920 --> 01:10:09,520 FREE TO ANSWER THEM. 1805 01:10:09,520 --> 01:10:11,280 YOU DO HAVE A CHATBOX FOR THOSE 1806 01:10:11,280 --> 01:10:12,560 THAT ARE NOT LISTED IN THIS 1807 01:10:12,560 --> 01:10:14,120 GROUP OF PARTICIPANTS. 1808 01:10:14,120 --> 01:10:16,600 WE WILL TAKE THE TIME TO ANSWER 1809 01:10:16,600 --> 01:10:17,520 YOU. 1810 01:10:17,520 --> 01:10:19,640 BECAUSE YOUR NAME OR YOUR 1811 01:10:19,640 --> 01:10:23,480 IDENTIFY WOULD BE UP THERE. 1812 01:10:23,480 --> 01:10:26,080 THANK YOU. 1813 01:10:26,080 --> 01:10:26,800 >> Lynn M. King: ARE THERE ANY 1814 01:10:26,800 --> 01:10:33,440 QUESTIONS OR COMMENTS FOR RENA? 1815 01:10:33,440 --> 01:10:37,720 >> I EXPECT SOME FROM THE 1816 01:10:37,720 --> 01:10:44,800 NEWCOMERS. 1817 01:10:44,800 --> 01:10:45,480 >> Lynn M. King: ANYONE? 1818 01:10:45,480 --> 01:10:47,080 DID ANYTHING RAISE QUESTIONS IN 1819 01:10:47,080 --> 01:10:48,640 TERMS IF I WASN'T CLEAR ENOUGH 1820 01:10:48,640 --> 01:10:50,040 OR DIDN'T COVER POINTS WELL 1821 01:10:50,040 --> 01:10:51,320 ENOUGH, ANYTHING LIKE THAT JUST 1822 01:10:51,320 --> 01:11:01,560 LET ME KNOW. 1823 01:11:05,080 --> 01:11:10,160 >> TERRY, ANYTHING THAT EXCITED 1824 01:11:10,160 --> 01:11:10,320 YOU? 1825 01:11:10,320 --> 01:11:19,320 >> YOUR AUDIO IS OFF. 1826 01:11:19,320 --> 01:11:25,360 >> Lynn M. King: UNMUTE 1827 01:11:25,360 --> 01:11:35,560 YOURSELF. 1828 01:12:32,800 --> 01:12:37,240 >> LIKE NEVER BEFORE. 1829 01:12:37,240 --> 01:12:40,200 THEY'RE GOING TO FUND THOSE THAT 1830 01:12:40,200 --> 01:12:40,680 FOSTER TA TEAM SCIENCE. 1831 01:12:40,680 --> 01:12:43,880 HOW THE CULTURE CHANGES AND 1832 01:12:43,880 --> 01:12:46,200 ACADEMIA AND HOW IT'S REWARDED 1833 01:12:46,200 --> 01:12:47,920 FOR TENURE, WE CAN GET INTO THAT 1834 01:12:47,920 --> 01:12:50,240 BUSINESS AND I HOPE IT HAPPENS 1835 01:12:50,240 --> 01:12:50,760 AT THE SAME TIME. 1836 01:12:50,760 --> 01:12:52,280 >> I HAD IN MIND SOMETHING LIKE 1837 01:12:52,280 --> 01:12:54,080 AN RFA. 1838 01:12:54,080 --> 01:12:58,840 NOT NECESSARILY A NEW MECHANISM 1839 01:12:58,840 --> 01:13:01,800 BUT BY HAVING AN RFA, YOU CAN 1840 01:13:01,800 --> 01:13:08,560 BRING REVIEWERS WHO ARE SIMBA 1841 01:13:08,560 --> 01:13:09,440 NET TICK TO THAT CONCEPT AND YOU 1842 01:13:09,440 --> 01:13:19,840 CAN HAVE HAD AS A FOCUS. 1843 01:13:21,280 --> 01:13:23,360 I THROW IT OUT AS SOMETHING TO 1844 01:13:23,360 --> 01:13:23,800 SPEAK ABOUT. 1845 01:13:23,800 --> 01:13:25,880 >> I INVITE LYNN TO COMMENT AS 1846 01:13:25,880 --> 01:13:26,080 WELL. 1847 01:13:26,080 --> 01:13:29,840 I WILL SAY RIGHT OFF THE TOP, WE 1848 01:13:29,840 --> 01:13:31,480 DON'T HAVE CRITICAL MASS OF 1849 01:13:31,480 --> 01:13:34,560 EXPERTISE IN OUR SCIENCES PEER 1850 01:13:34,560 --> 01:13:36,120 REVIEW TENDS TO BE NOT AS 1851 01:13:36,120 --> 01:13:38,520 REWARDING TO ORAL HEALTH RELATED 1852 01:13:38,520 --> 01:13:44,160 PROJECTS AS IT COULD BE. 1853 01:13:44,160 --> 01:13:46,800 WE HAVE TO CREATE TA PATHWAY FOR 1854 01:13:46,800 --> 01:13:50,480 INDIVIDUALS TO BE REPRESENTED IN 1855 01:13:50,480 --> 01:13:50,720 PEOPLE. 1856 01:13:50,720 --> 01:13:52,800 >> THANK YOU FOR POSTING THE 1857 01:13:52,800 --> 01:13:53,200 COMMENTS. 1858 01:13:53,200 --> 01:13:55,240 SO, DANA, YOU WOULD BE, I HOPE 1859 01:13:55,240 --> 01:13:58,200 YOU WOULD BE PLEASED TO HEAR THE 1860 01:13:58,200 --> 01:14:03,200 FIRST CONCEPT IN THE CLEARANCE 1861 01:14:03,200 --> 01:14:05,960 AT ABOUT 1:25 THIS AFTERNOON. 1862 01:14:05,960 --> 01:14:10,520 IT IS A CONCEPT TO EMPHASIS 1863 01:14:10,520 --> 01:14:12,360 COLLABORATIVE SCIENCE, TO BRING 1864 01:14:12,360 --> 01:14:14,760 UPON DIS REPRESENTATIVE 1865 01:14:14,760 --> 01:14:16,240 TECHNOLOGIES AND NEW KNOWLEDGE 1866 01:14:16,240 --> 01:14:21,120 TO A FIELD THAT MIGHT HAVE NOT 1867 01:14:21,120 --> 01:14:23,360 BEEN PROCESSING AS FAST AS WE 1868 01:14:23,360 --> 01:14:26,200 WANT IT TO. 1869 01:14:26,200 --> 01:14:26,800 SO STAY TUNED. 1870 01:14:26,800 --> 01:14:28,640 >> YES. 1871 01:14:28,640 --> 01:14:30,080 THANK YOU, LILLIAN. 1872 01:14:30,080 --> 01:14:32,160 >> I JUST WANTED TO TELL YOU 1873 01:14:32,160 --> 01:14:37,600 THAT FRANKLY I WAS OVERWHELMED. 1874 01:14:37,600 --> 01:14:40,400 I HAD NO IDEA THAT ALL THIS 1875 01:14:40,400 --> 01:14:41,840 STUFF GOES ON WITH NIDCR AND 1876 01:14:41,840 --> 01:14:43,000 MAYBE THAT'S SOMETHING THAT 1877 01:14:43,000 --> 01:14:43,880 NEEDS TO BE CHANGED. 1878 01:14:43,880 --> 01:14:45,920 I THINK THE PRACTICING COMMUNITY 1879 01:14:45,920 --> 01:14:49,880 NEEDS TO BE AWARE OF ALL OF THE 1880 01:14:49,880 --> 01:14:50,960 THINGS THAT NIDCR DOES. 1881 01:14:50,960 --> 01:14:57,520 I MEAN, IT'S JUST BLOWING AWAY, 1882 01:14:57,520 --> 01:14:58,600 IT'S AMAZING. 1883 01:14:58,600 --> 01:15:01,280 >> I'M GOING TO TRY -- IT'S 1884 01:15:01,280 --> 01:15:02,760 NEVER TO SHOWCASE AS MUCH AS IT 1885 01:15:02,760 --> 01:15:12,480 IS TO INVITE. 1886 01:15:12,480 --> 01:15:13,280 THANK YOU. 1887 01:15:13,280 --> 01:15:15,720 FOR US IT MEANS THAT THERE'S -- 1888 01:15:15,720 --> 01:15:21,680 WE NED TO DO MORE IN THE AREA OF 1889 01:15:21,680 --> 01:15:22,000 COMMUNICATION. 1890 01:15:22,000 --> 01:15:25,080 THANK YOU. 1891 01:15:25,080 --> 01:15:26,800 WE CAN MOVE ON, BECAUSE I CAN 1892 01:15:26,800 --> 01:15:29,200 ADDRESS THE OTHER CONCEPTS, OR 1893 01:15:29,200 --> 01:15:31,400 THE OTHER QUESTIONS AS THEY 1894 01:15:31,400 --> 01:15:31,640 ARISE. 1895 01:15:31,640 --> 01:15:32,800 >> Lynn M. King: THAT SOUNDS 1896 01:15:32,800 --> 01:15:33,280 GOOD. 1897 01:15:33,280 --> 01:15:39,040 SO THE NEXT IS Dr. ROBERT 1898 01:15:39,040 --> 01:15:40,360 CARTER FROM THE NATIONAL 1899 01:15:40,360 --> 01:15:43,480 INSTITUTE OF ARTHRITIS AND 1900 01:15:43,480 --> 01:15:44,800 MUSCULO SKELETAL DISEASES. 1901 01:15:44,800 --> 01:15:46,880 >> GOOD MORNING AND THANK YOU, I 1902 01:15:46,880 --> 01:15:47,560 REALLY ENJOYED BEING HERE AND 1903 01:15:47,560 --> 01:15:52,120 CAUGHT THE END OF THAT 1904 01:15:52,120 --> 01:15:54,160 CONVERSATION AND THIS IS QUITE 1905 01:15:54,160 --> 01:15:54,560 GERMANE. 1906 01:15:54,560 --> 01:15:55,800 WHEN WE TALK ABOUT OUR 1907 01:15:55,800 --> 01:15:57,480 APPROACHES TO COMPLEX DISEASES 1908 01:15:57,480 --> 01:15:58,680 AND PARTICULARLY BECAUSE WE'VE 1909 01:15:58,680 --> 01:16:02,640 HAD THE CHANCE TO WORK WITH 1910 01:16:02,640 --> 01:16:03,600 NIDCR ON THESE IN TWO DIFFERENT 1911 01:16:03,600 --> 01:16:06,840 CASE AND I'M GOING TO GO BEYOND 1912 01:16:06,840 --> 01:16:08,480 PACK BACK BUT THE POINT IS TO 1913 01:16:08,480 --> 01:16:12,520 LESSONS LEARNED OF HOW WE PUT 1914 01:16:12,520 --> 01:16:16,640 TOGETHER GROUPS TO TACKLE THESE 1915 01:16:16,640 --> 01:16:19,680 COMPLEX PROBLEMS AND I DO NEED 1916 01:16:19,680 --> 01:16:24,080 TO START THE ROT, RPG REMAINS 1917 01:16:24,080 --> 01:16:26,680 THE BETTER ACTIVE NIH FUNDING 1918 01:16:26,680 --> 01:16:27,560 RESEARCH BECAUSE INDIVIDUALS 1919 01:16:27,560 --> 01:16:32,720 DRIVE INNOVATIONS AND I DO WANT 1920 01:16:32,720 --> 01:16:34,240 TO MADE AND YOU HAVE TO BRING 1921 01:16:34,240 --> 01:16:37,000 MORE THAN ONE DISCIPLINE INTO 1922 01:16:37,000 --> 01:16:37,720 PLAY TO UNDERSTAND THEM AND 1923 01:16:37,720 --> 01:16:39,720 UNLESS IT TAKES A TEAM TO TACKLE 1924 01:16:39,720 --> 01:16:41,160 THE COMPLEX PROBLEMS AND THAT IS 1925 01:16:41,160 --> 01:16:44,560 THE FOCUS FOR TODAY, NEXT SLIDE. 1926 01:16:44,560 --> 01:16:48,440 SO WE'LL START WITH BACKPACK AND 1927 01:16:48,440 --> 01:16:49,400 I DON'T BEYOND THAT. 1928 01:16:49,400 --> 01:16:51,320 THIS IS ONE THAT I THINK YOU 1929 01:16:51,320 --> 01:16:53,320 WILL SEE SOME PARALLELS BETWEEN 1930 01:16:53,320 --> 01:16:55,600 SOME OF THE ISSUES THAT YOU HAVE 1931 01:16:55,600 --> 01:17:02,040 DEALT WITH AND PARTICULARLY 1932 01:17:02,040 --> 01:17:02,760 DISORDERS. 1933 01:17:02,760 --> 01:17:04,680 BACKPACK IS A CONSORTIUM IN THIS 1934 01:17:04,680 --> 01:17:06,560 DOES GET TO THE QUESTION ABOUT 1935 01:17:06,560 --> 01:17:07,600 RFAs BECAUSE IT'S VERY 1936 01:17:07,600 --> 01:17:08,800 IMPORTANT THAT YOU PUT TOGETHER 1937 01:17:08,800 --> 01:17:11,680 A NETWORK NOT JUST INDIVIDUAL 1938 01:17:11,680 --> 01:17:13,400 INVESTIGATORS, WHO COME FROM 1939 01:17:13,400 --> 01:17:16,040 DIFFERENT PERSPECTIVES. 1940 01:17:16,040 --> 01:17:20,680 FOR BACPAC IT'S THE INTEGRATED 1941 01:17:20,680 --> 01:17:23,760 MODEL OF LOW BACK PAIN, THE 1942 01:17:23,760 --> 01:17:34,760 TRANSLATION ALF TRANSLATION AL S 1943 01:17:34,760 --> 01:17:36,640 THAT BEST -- TO WHICH THEY WILL 1944 01:17:36,640 --> 01:17:37,720 RESPOND BEST WHICH YOU KNOW 1945 01:17:37,720 --> 01:17:41,720 ABOUT THEIR PHENOTYPE IN THE 1946 01:17:41,720 --> 01:17:43,080 CYCLE SOCIAL CONTEXT. 1947 01:17:43,080 --> 01:17:49,840 SO THE STRUCTURE FOR BACPAC THAT 1948 01:17:49,840 --> 01:17:50,600 PULSE DATA FROM THE DIFFERENT 1949 01:17:50,600 --> 01:17:50,920 SITES. 1950 01:17:50,920 --> 01:18:01,480 THERE'S A DOCK TECHNOLOGY SIT 1951 01:18:08,600 --> 01:18:10,480 SITES -- THERE ARE THREE 1952 01:18:10,480 --> 01:18:11,880 MECHANISTIC RESEARCH CENTERS. 1953 01:18:11,880 --> 01:18:13,400 THESE BRING DIFFERENT 1954 01:18:13,400 --> 01:18:14,600 PERSPECTIVES TO BACK PAIN, ONE 1955 01:18:14,600 --> 01:18:19,200 AT UCSF IS FOCUSED ON THE 1956 01:18:19,200 --> 01:18:21,120 INPLAIN AND ONE AT MICHIGAN 1957 01:18:21,120 --> 01:18:22,880 FOCUSED ON CENTRAL MECHANISMS OF 1958 01:18:22,880 --> 01:18:24,760 PAIN AND PAIN PROCESSING, AND 1959 01:18:24,760 --> 01:18:27,120 THE THIRD IS PITTSBURG FOCUSED 1960 01:18:27,120 --> 01:18:28,800 ON CLINICAL TREATMENT IN 1961 01:18:28,800 --> 01:18:30,360 OUTCOMES OF PATIENTS WITH 1962 01:18:30,360 --> 01:18:32,480 CHRONIC LOW BACK PAIN. 1963 01:18:32,480 --> 01:18:35,720 SO, IT DOES TAKE A GROUP OF 1964 01:18:35,720 --> 01:18:37,080 INDIVIDUALS WITH DIFFERENT 1965 01:18:37,080 --> 01:18:38,320 EXPERTISE TO COME TOGETHER IN 1966 01:18:38,320 --> 01:18:40,120 THE NETWORK. 1967 01:18:40,120 --> 01:18:43,080 AND IT WAS ALLUDED TO THE RFA 1968 01:18:43,080 --> 01:18:45,240 ACTUALLY IS A SEPARATE REVIEW 1969 01:18:45,240 --> 01:18:47,280 PROCESS FROM THE USUAL RO1s 1970 01:18:47,280 --> 01:18:50,560 AND IN THE SELECTING SITES TO 1971 01:18:50,560 --> 01:18:52,600 FUND IT'S NOT ABOUT WHO SCORES 1972 01:18:52,600 --> 01:18:54,200 THE BEST, IT'S ABOUT WHO IS 1973 01:18:54,200 --> 01:18:55,920 GOING TO CONTRIBUTE THE MOST TO 1974 01:18:55,920 --> 01:18:58,600 THE NETWORK AND WHAT YOUR GOAL 1975 01:18:58,600 --> 01:19:00,840 IS, IS A NETWORK WHERE THE 1976 01:19:00,840 --> 01:19:03,200 OUTPUT IS CONSIDERABLY MORE THAN 1977 01:19:03,200 --> 01:19:04,280 THE SUM OF THE INDIVIDUAL 1978 01:19:04,280 --> 01:19:09,720 CENTERS THAT YOU FUND. 1979 01:19:09,720 --> 01:19:15,440 NIH HAS TO NOT SURE TO ENSURE FK 1980 01:19:15,440 --> 01:19:15,720 TOGETHER. 1981 01:19:15,720 --> 01:19:17,800 IT ISN'T EASY, SOMETIMES IT 1982 01:19:17,800 --> 01:19:18,760 TAKES BLOOD AND TEARS. 1983 01:19:18,760 --> 01:19:20,400 BUT I WOULD SAY WE GENERALLY GET 1984 01:19:20,400 --> 01:19:21,480 THERE IN ALL CASES. 1985 01:19:21,480 --> 01:19:22,800 I'M GOING TO SPEAK QUICKLY ABOUT 1986 01:19:22,800 --> 01:19:24,680 A CO-OPERATIVE CLINICAL TRIAL 1987 01:19:24,680 --> 01:19:26,080 WITH THE GROUP IS DOING ACROSS 1988 01:19:26,080 --> 01:19:28,960 THE NETWORK. 1989 01:19:28,960 --> 01:19:31,360 SO FIRST, I'M GOING TO FOCUS ON 1990 01:19:31,360 --> 01:19:32,840 THIS THEORETICAL MODEL OF LOW 1991 01:19:32,840 --> 01:19:33,560 BACK PAIN. 1992 01:19:33,560 --> 01:19:35,360 IN THIS TAKES JUST THE PARTS OF 1993 01:19:35,360 --> 01:19:37,960 THE BODY THAT ARE FOCUSING OF 1994 01:19:37,960 --> 01:19:39,840 LOW BACK PAIN ON THE BOTTOM OF 1995 01:19:39,840 --> 01:19:41,280 THE THINGS THAT HAPPEN IN THE 1996 01:19:41,280 --> 01:19:41,520 SPINE. 1997 01:19:41,520 --> 01:19:42,960 THE DIFFERENT COMPONENTS OF THE 1998 01:19:42,960 --> 01:19:44,200 SPINE THAT CONTRIBUTE TO THE 1999 01:19:44,200 --> 01:19:44,400 PAIN. 2000 01:19:44,400 --> 01:19:45,600 IN THE MIDDLE IS THE 2001 01:19:45,600 --> 01:19:49,160 TRANSMISSION OF THE SIGNALS FROM 2002 01:19:49,160 --> 01:19:50,680 THIS LOCAL STRUCTURES IN THE 2003 01:19:50,680 --> 01:19:51,800 SPINE THROUGH THE SPINAL CORD 2004 01:19:51,800 --> 01:19:53,600 AND THE TOP IS THE PROCESSING OF 2005 01:19:53,600 --> 01:19:55,720 PAIN IN THE CNS. 2006 01:19:55,720 --> 01:19:57,600 SOME OF THIS IS SPECIFIC TO LOW 2007 01:19:57,600 --> 01:20:00,160 BACK PAIN AND A LOT OF IT 2008 01:20:00,160 --> 01:20:01,360 ACTUALLY COULD BE USED FOR 2009 01:20:01,360 --> 01:20:04,240 ALMOST ANY DISEASE WHERE THIS IS 2010 01:20:04,240 --> 01:20:06,480 PERIPHERAL PAIN MECHANISM OR 2011 01:20:06,480 --> 01:20:10,480 EVEN A TMD PAIN MECHANISM, IN 2012 01:20:10,480 --> 01:20:15,960 THE TRY AGAINERRAL GANGLION FOR 2013 01:20:15,960 --> 01:20:17,160 DOR SAL GANGLIA. 2014 01:20:17,160 --> 01:20:22,080 IT'S COMPLICATED ENOUGH, ALL THE 2015 01:20:22,080 --> 01:20:22,760 DIFFERENT PARTS AND 2016 01:20:22,760 --> 01:20:23,840 UNDERSTANDING THEM. 2017 01:20:23,840 --> 01:20:25,280 THE RESPONSE TO PAIN AND 2018 01:20:25,280 --> 01:20:26,840 RESPONSE TO INTERVENTIONS TO 2019 01:20:26,840 --> 01:20:29,040 REDUCE PAIN, ARE HUGELY 2020 01:20:29,040 --> 01:20:30,960 INFLUENCED BY A NUMBER OF 2021 01:20:30,960 --> 01:20:31,920 FACTORS BEYOND WHAT IS HAPPENING 2022 01:20:31,920 --> 01:20:34,560 IN THE LOCAL STRUCTURES OR IN 2023 01:20:34,560 --> 01:20:36,040 THE CENTRAL PROCESSING. 2024 01:20:36,040 --> 01:20:37,840 AND YOU CAN SEE ALL THE 2025 01:20:37,840 --> 01:20:39,680 DIFFERENT BOXES HERE THAT 2026 01:20:39,680 --> 01:20:41,240 OUTLINE THOSE DIFFERENT FACTORS 2027 01:20:41,240 --> 01:20:43,240 OUTSIDE OF THE PERSON THAT CAN 2028 01:20:43,240 --> 01:20:45,000 CONTRIBUTE TO THE EXPERIENCE OF 2029 01:20:45,000 --> 01:20:45,280 PAIN. 2030 01:20:45,280 --> 01:20:51,840 THE CRUCIAL FACT IN BOTH THIS 2031 01:20:51,840 --> 01:20:53,600 SLIDE AND THE ONE BEFORE, WE ARE 2032 01:20:53,600 --> 01:20:55,040 POPULATING THESE BOXES WITH DATA 2033 01:20:55,040 --> 01:20:59,120 DRAWING ON PREVIOUS PATIENTS 2034 01:20:59,120 --> 01:21:00,760 PHENOTYPE FOR OTHER LOW BACK 2035 01:21:00,760 --> 01:21:02,600 PAIN AS WELL AS THE OTHERS WHO 2036 01:21:02,600 --> 01:21:04,200 RECRUITED WITHIN BACPAC SO WE 2037 01:21:04,200 --> 01:21:11,880 CAN PUT NUMBERS ON THESE DIFFERT 2038 01:21:11,880 --> 01:21:13,040 BOXES ON SECESSION OF PAIN AND 2039 01:21:13,040 --> 01:21:15,160 THE OUTCOMES OF INTERVENTIONS ON 2040 01:21:15,160 --> 01:21:15,440 PATIENTS. 2041 01:21:15,440 --> 01:21:16,800 AGAIN, IF YOU TAKE A LOOK AT 2042 01:21:16,800 --> 01:21:18,680 THIS, PRETTY MUCH EVERY ONE OF 2043 01:21:18,680 --> 01:21:24,160 THESE BOXES CAN BE QUITE 2044 01:21:24,160 --> 01:21:27,960 IMPACTED AND SIMILAR TO SAY TMD. 2045 01:21:27,960 --> 01:21:29,520 THIS MODEL IS GENERALIZABLE. 2046 01:21:29,520 --> 01:21:33,520 THERE ARE A FEW THINGS THAT ARE 2047 01:21:33,520 --> 01:21:34,120 DIFFERENT. 2048 01:21:34,120 --> 01:21:35,880 THE FEMALE PREDOMINANCE SO THERE 2049 01:21:35,880 --> 01:21:37,640 ARE OTHER ISSUES AND I THINK 2050 01:21:37,640 --> 01:21:40,320 THIS TYPE OF EXERCISE OF 2051 01:21:40,320 --> 01:21:41,280 UNDERSTANDING AS BEST YOU CAN 2052 01:21:41,280 --> 01:21:42,680 THE DIFFERENT FACTORS THAT 2053 01:21:42,680 --> 01:21:47,280 IMPORTANT TO CONTRIBUTORS OF 2054 01:21:47,280 --> 01:21:49,240 PAIN, QUANTITYTATIVE THROUGH 2055 01:21:49,240 --> 01:21:50,520 BIG-DATA EFFORTS AND USING IT AS 2056 01:21:50,520 --> 01:21:54,240 A PREDICTIVE MODEL IS PART OF 2057 01:21:54,240 --> 01:21:54,640 THE FUTURE. 2058 01:21:54,640 --> 01:21:56,080 THE OTHER THING I WANT TODAY 2059 01:21:56,080 --> 01:21:57,840 TOUCH ON WAS THIS CO-OPERATIVE 2060 01:21:57,840 --> 01:21:58,520 CLINICAL TRIAL. 2061 01:21:58,520 --> 01:22:01,840 SO IT'S A VERY BROAD, VERY FEW 2062 01:22:01,840 --> 01:22:03,360 EXCLUSION FOR PATIENTS WITH 2063 01:22:03,360 --> 01:22:05,720 CHRONIC LOW BACK PAIN AND THIS 2064 01:22:05,720 --> 01:22:09,000 IS INITIAL RANDOM NATION TO ONE 2065 01:22:09,000 --> 01:22:10,400 OF FOUR DIFFERENT INTERVENTIONS 2066 01:22:10,400 --> 01:22:13,840 THAT ARE DIFFERENT AND AT 12 2067 01:22:13,840 --> 01:22:15,920 WEEKS, WHICH ACTS AS THE INITIAL 2068 01:22:15,920 --> 01:22:17,000 RANDOMIZATION, THE PATIENTS ARE 2069 01:22:17,000 --> 01:22:17,680 SEEN AGAIN. 2070 01:22:17,680 --> 01:22:19,480 IT'S INTERESTING THE DESIGN HERE 2071 01:22:19,480 --> 01:22:20,840 IS THAT IF THE PATIENTS ARE 2072 01:22:20,840 --> 01:22:22,440 DOING WELL, THEY CAN CONTINUE ON 2073 01:22:22,440 --> 01:22:25,480 WHATEVER THE INITIAL 2074 01:22:25,480 --> 01:22:26,320 RANDOMIZATION WAS. 2075 01:22:26,320 --> 01:22:27,280 THEY'RE DOING OK BUT NOT QUITE 2076 01:22:27,280 --> 01:22:28,120 WHERE YOU WANT. 2077 01:22:28,120 --> 01:22:30,320 YOU CAN ADD AN INTERVENTION. 2078 01:22:30,320 --> 01:22:32,200 OR IF THE PATIENT IS REALLY 2079 01:22:32,200 --> 01:22:34,480 HAVEN'T BENEFITED, DROP THE 2080 01:22:34,480 --> 01:22:35,640 INITIAL INTERVENTION AND MOVE ON 2081 01:22:35,640 --> 01:22:36,720 TO A DIFFERENT ONE. 2082 01:22:36,720 --> 01:22:41,320 SO YOU CAN GET BOTH DATA ON THE 2083 01:22:41,320 --> 01:22:43,440 IMPACT OF SEQUENTIAL 2084 01:22:43,440 --> 01:22:44,960 INTERVENTIONS AS WELL AS 2085 01:22:44,960 --> 01:22:48,760 MULTIPLE INTERVENTIONS INCLUDING 2086 01:22:48,760 --> 01:22:50,160 ADDING OBJECT SUBTRACTING SO 2087 01:22:50,160 --> 01:22:53,320 IT'S DIFFERENT THAN THE USUAL 2088 01:22:53,320 --> 01:22:56,680 CLINICAL TRIAL. 2089 01:22:56,680 --> 01:22:59,480 IN THE CRITICAL POINT THIS IS 2090 01:22:59,480 --> 01:23:00,640 NOT POWERED TO UNDERSTAND WHAT 2091 01:23:00,640 --> 01:23:05,880 IS BEST FOR THE POPULATION. 2092 01:23:05,880 --> 01:23:07,200 IT'S POWERED TO WE CAN DETECT A 2093 01:23:07,200 --> 01:23:09,600 DIFFERENCE IN OUTCOME, ON THE 2094 01:23:09,600 --> 01:23:11,000 INTERVENTION BASED ON THE 2095 01:23:11,000 --> 01:23:19,200 PATIENT'S PRESENTING PHENOTYPE. 2096 01:23:19,200 --> 01:23:22,440 IT REQUIRES MODELING TO 2097 01:23:22,440 --> 01:23:25,200 DETERMINE THE TYPES OF PATIENTS 2098 01:23:25,200 --> 01:23:27,200 WHO RESPOND BEST TO WHICH 2099 01:23:27,200 --> 01:23:28,880 TREATMENTS SO A VERY DIFFERENT 2100 01:23:28,880 --> 01:23:31,080 TYPE OF APPROACH TO A COMPLEX, 2101 01:23:31,080 --> 01:23:32,160 CLINICAL PROBLEM WITH ALL THOSE 2102 01:23:32,160 --> 01:23:36,240 DIFFERENT COMPONENTS THAT GO 2103 01:23:36,240 --> 01:23:45,760 INTO IT. 2104 01:23:45,760 --> 01:23:47,600 THE NEXT ARE TO ALLOW TREATMENT 2105 01:23:47,600 --> 01:23:48,640 FOR OUTCOME. 2106 01:23:48,640 --> 01:23:50,720 GOING ON BEHIND THAT ARE ALL THE 2107 01:23:50,720 --> 01:23:53,000 MECHANISTIC STUDIES SO WE CAN 2108 01:23:53,000 --> 01:23:54,960 UNDERSTAND HOW THE PATIENT 2109 01:23:54,960 --> 01:23:56,960 PHENOTYPE IS LINKED TO THE 2110 01:23:56,960 --> 01:23:58,640 MECHANISMS IN THE BODY TO 2111 01:23:58,640 --> 01:24:02,320 CONTRIBUTE TO PAIN AND USE THOSE 2112 01:24:02,320 --> 01:24:03,120 TO UNDERSTAND THE TRANSLATION TO 2113 01:24:03,120 --> 01:24:05,280 BLOCK THOSE MECHANISMS OF PAIN 2114 01:24:05,280 --> 01:24:10,160 TO IMPROVE OUTCOMES IN THE LONG 2115 01:24:10,160 --> 01:24:11,320 RUN. 2116 01:24:11,320 --> 01:24:12,920 SO THE SECOND INITIATIVE I'D 2117 01:24:12,920 --> 01:24:14,960 LIKE TO DESCRIBE TO DO TODAY 2118 01:24:14,960 --> 01:24:18,760 THAT WE HAVE UNDERTAKEN JOINTLY 2119 01:24:18,760 --> 01:24:20,320 WITH NIDCR WITH RENA'S 2120 01:24:20,320 --> 01:24:22,400 LEADERSHIP IS REJOIN. 2121 01:24:22,400 --> 01:24:24,200 THE ACRONYM COMES OUT OF 2122 01:24:24,200 --> 01:24:25,000 RESTORING JOINT HEALTH. 2123 01:24:25,000 --> 01:24:26,360 THE CONCEPT HERE IS WE SHOULD 2124 01:24:26,360 --> 01:24:28,960 TAKE THE JOINT AS A WHOLE ORGAN. 2125 01:24:28,960 --> 01:24:32,240 THAT WE CAN'T JUST CONSIDER SAY 2126 01:24:32,240 --> 01:24:35,240 THE CARTILAGE AND UNDERSTAND 2127 01:24:35,240 --> 01:24:35,720 OSTEO ARTHRITIS. 2128 01:24:35,720 --> 01:24:39,680 SO THE NEXT SLIDE -- WE TAKE ALL 2129 01:24:39,680 --> 01:24:42,200 THOSE DIFFERENT COMPONENTS AND 2130 01:24:42,200 --> 01:24:45,000 THIS DOESN'T HAVE TO BE SOME 2131 01:24:45,000 --> 01:24:47,320 NICHE HERE AND THIS COULD BE 2132 01:24:47,320 --> 01:24:48,440 OTHER JOINTS YOU WITH PICK YOUR 2133 01:24:48,440 --> 01:24:52,760 FAVORITE ONE INCLUDING THE TMJ 2134 01:24:52,760 --> 01:24:54,200 AND WE ASCERTAIN WHAT IS 2135 01:24:54,200 --> 01:24:55,880 HAPPENING IN THOSE DIFFERENT 2136 01:24:55,880 --> 01:24:58,120 TISSUES ACROSS ALL THOSE 2137 01:24:58,120 --> 01:24:59,880 DIFFERENT THINGS AND THE CONCEPT 2138 01:24:59,880 --> 01:25:01,520 IS THE DIFFERENT TYPES OF PAIN 2139 01:25:01,520 --> 01:25:04,120 COMING OUT OF DIFFERENT TYPES OF 2140 01:25:04,120 --> 01:25:06,840 MCCAINAL INJURIES AND WILL 2141 01:25:06,840 --> 01:25:10,760 RESULT IN INJURIES FOR THESE 2142 01:25:10,760 --> 01:25:13,680 DIFFERENT COMPONENTS AND THEY 2143 01:25:13,680 --> 01:25:14,920 MANIFEST DIFFERENTLY IN TERMS OF 2144 01:25:14,920 --> 01:25:16,760 SYMPTOMS AND IMPORTANTLY HELP 2145 01:25:16,760 --> 01:25:18,680 DETERMINE WHICH INTERVENTIONS 2146 01:25:18,680 --> 01:25:19,960 TARGETED WHICH TISSUE WILL MOST 2147 01:25:19,960 --> 01:25:29,120 HELP THAT GIVEN PATIENT. 2148 01:25:29,120 --> 01:25:33,840 THE YOU WILL MALT ULTIMATE GOALD 2149 01:25:33,840 --> 01:25:35,480 TO TISSUE DAMAGE WHETHER IT'S IN 2150 01:25:35,480 --> 01:25:39,440 THE TMD OR THE SPINE OR KNEE OR 2151 01:25:39,440 --> 01:25:40,040 WHAT HAVE YOU. 2152 01:25:40,040 --> 01:25:43,400 AS A FIRST STEP WE'RE DOING IN 2153 01:25:43,400 --> 01:25:47,280 REJOIN IS SHOWN BEFORE THE 2154 01:25:47,280 --> 01:25:49,320 ARCTIC YOU LAR TISSUE IS 2155 01:25:49,320 --> 01:25:50,720 STUDYING WHICH NERVES ARE 2156 01:25:50,720 --> 01:25:54,800 PRESENT IN THOSE TISSUE AND 2157 01:25:54,800 --> 01:25:55,840 WHETHER THEY DIFFER BETWEEN 2158 01:25:55,840 --> 01:26:01,440 INDIVIDUALS AND THE 2159 01:26:01,440 --> 01:26:03,800 HYPOTHESIS IS THERE ARE 2160 01:26:03,800 --> 01:26:07,160 DIFFERENT NOI NERVES THAT MAKE P 2161 01:26:07,160 --> 01:26:08,720 THE JOINT AND THEY'RE 2162 01:26:08,720 --> 01:26:09,800 RESPONSIBLE FOR THE DIFFERENT 2163 01:26:09,800 --> 01:26:10,440 PAIN I DESCRIBED. 2164 01:26:10,440 --> 01:26:12,240 IN ADDITION, WITH WE KNOW WHAT 2165 01:26:12,240 --> 01:26:14,040 TYPES OF NERVES ARE THERE, WE 2166 01:26:14,040 --> 01:26:15,960 KNOW AND FROM THE EXPRESSION 2167 01:26:15,960 --> 01:26:17,960 PROFILES OF THOSE TYPES OF 2168 01:26:17,960 --> 01:26:20,320 NERVES, WHAT MEDIATORS ARE 2169 01:26:20,320 --> 01:26:23,280 ACTIVATING THEM, WE CAN THEN USE 2170 01:26:23,280 --> 01:26:26,320 THEM TO BLOCK THOSE TYPES OF 2171 01:26:26,320 --> 01:26:28,560 ACTIVATION AND REDUCE PAIN SO 2172 01:26:28,560 --> 01:26:30,520 LONG-TERM GOAL OF RESTORING 2173 01:26:30,520 --> 01:26:32,280 JOINT HEALTH BY CONSIDERING THE 2174 01:26:32,280 --> 01:26:34,560 PERSON AND THE JOINTS AS WHOLE 2175 01:26:34,560 --> 01:26:40,280 THINGS, WITH FOCUS ON INITIALLY 2176 01:26:40,280 --> 01:26:46,720 FOR THE NERVES. 2177 01:26:46,720 --> 01:26:48,560 WE EXPECT THESE NOTICE OF WORDS 2178 01:26:48,560 --> 01:26:59,080 TO GO OUT IN THERE'S MORE NEWS 2179 01:27:52,280 --> 01:27:55,080 TO FINDMENT TURNING TO THE 2180 01:27:55,080 --> 01:27:55,640 ACCELERATING MEDICINE 2181 01:27:55,640 --> 01:27:59,160 PARTNERSHIP THAT WE ALLUDED TO 2182 01:27:59,160 --> 01:28:00,320 AND I HAVE BEEN WATCHING THIS 2183 01:28:00,320 --> 01:28:04,800 FOR OVER A DECADE WHICH HAS BEEN 2184 01:28:04,800 --> 01:28:05,520 MY PLEASURE. 2185 01:28:05,520 --> 01:28:07,440 IT'S A PARTNERSHIP MADE UP OF 2186 01:28:07,440 --> 01:28:09,760 BOTH OF NIH AND INDUSTRY AND 2187 01:28:09,760 --> 01:28:10,680 ADVOCACY GROUPS. 2188 01:28:10,680 --> 01:28:12,480 IT WAS STARTED WHEN FRANCIS 2189 01:28:12,480 --> 01:28:13,760 COLLINS WAS AT A MEETING OF THE 2190 01:28:13,760 --> 01:28:17,880 HEADS OF RND OF MAJOR PHARMA 2191 01:28:17,880 --> 01:28:21,680 COMPANIES WHO WERE NOTING THE 2192 01:28:21,680 --> 01:28:23,080 FACT THEY WERE HAVING FAILURES 2193 01:28:23,080 --> 01:28:25,760 IN THEIR PHASE 3 BILLION-DOLLAR 2194 01:28:25,760 --> 01:28:26,320 CLINICAL TRIALS AND THEY'RE 2195 01:28:26,320 --> 01:28:29,040 FAILING FOR LACK OF EFFICACY AND 2196 01:28:29,040 --> 01:28:31,040 WE REALLY DIDN'T UNDERSTAND THE 2197 01:28:31,040 --> 01:28:33,240 ROLE OF SPECIFIC TARGETS IN THIS 2198 01:28:33,240 --> 01:28:34,320 DISEASE AND SO SOME OF THE 2199 01:28:34,320 --> 01:28:35,680 THINGS THAT WE WERE TARGETING 2200 01:28:35,680 --> 01:28:39,000 JUST WEREN'T WORKING. 2201 01:28:39,000 --> 01:28:41,840 THIS STARTED WITH THREE PROJECTS 2202 01:28:41,840 --> 01:28:44,080 ONE OF WHICH WILL HELP LEAD IN 2203 01:28:44,080 --> 01:28:45,240 ARTHRITIS AND LUPUS BUT IT'S 2204 01:28:45,240 --> 01:28:46,560 GONE TO NINE DIFFERENT PROGRAMS 2205 01:28:46,560 --> 01:28:48,400 AND I'M GOING TO INTRODUCE A 2206 01:28:48,400 --> 01:28:52,040 PARTICULAR TENTH ONE AT THE END. 2207 01:28:52,040 --> 01:28:52,880 NEXT SLIDE. 2208 01:28:52,880 --> 01:28:58,440 SO THIS STARTED WITH THE RIN 2209 01:28:58,440 --> 01:29:00,480 LUPUS TO IDENTIFY TARGETS THAT 2210 01:29:00,480 --> 01:29:04,240 COULD BE BETTER FOR DRUG TARGETS 2211 01:29:04,240 --> 01:29:05,880 FOR TREATING PATIENTS BEYOND 2212 01:29:05,880 --> 01:29:06,720 WHAT WE CAN DO NOW. 2213 01:29:06,720 --> 01:29:09,560 IN THE FOCUS WHAT WAS WE CALLED 2214 01:29:09,560 --> 01:29:10,280 DISEASE DECONSTRUCTION. 2215 01:29:10,280 --> 01:29:11,840 ONE OF THE KEY THINGS THAT WE 2216 01:29:11,840 --> 01:29:14,360 COULD DO, WAS START GETTING 2217 01:29:14,360 --> 01:29:15,760 BIOPSIES OF THE TARGET TISSUE 2218 01:29:15,760 --> 01:29:18,760 FROM PATIENTS WITH LUPUS SO WE 2219 01:29:18,760 --> 01:29:22,400 DID RESEARCH BIOPSIES IN 2220 01:29:22,400 --> 01:29:24,360 ARTHRITIS AND WE ALSO COULD GET 2221 01:29:24,360 --> 01:29:26,000 FRAGMENTS OF KIDNEYS FROM 2222 01:29:26,000 --> 01:29:28,360 PATIENTS WHO ARE UNDERGOING 2223 01:29:28,360 --> 01:29:30,480 MEDICAL INDICATED KIDNEY 2224 01:29:30,480 --> 01:29:33,800 BIOPSIES FROM LUPUS AND WE DIS 2225 01:29:33,800 --> 01:29:35,280 AGGREGATE THE CELLS AND 2226 01:29:35,280 --> 01:29:36,280 INTERROGATE THEM WITH THE 2227 01:29:36,280 --> 01:29:39,360 EMERGING TECHNOLOGIES FOR SINGLE 2228 01:29:39,360 --> 01:29:41,920 CELL PROTEIN EXPRESSION AND THEN 2229 01:29:41,920 --> 01:29:44,360 MAP THE INTRA CELLULAR PATHWAYS 2230 01:29:44,360 --> 01:29:46,280 THAT WERE ACTIVE AND LOOK AT THE 2231 01:29:46,280 --> 01:29:47,800 DIFFERENT CELLS AND SUBSETS AND 2232 01:29:47,800 --> 01:29:49,480 THE STATE OF THE CELLS AND THEN 2233 01:29:49,480 --> 01:29:51,240 LOOK FOR CLINICAL CORRELATIONS 2234 01:29:51,240 --> 01:29:52,800 AND I HAVE TO SAY, ACTUALLY, IT 2235 01:29:52,800 --> 01:29:56,600 WAS REMARKABLY SUCCESSFUL AND WE 2236 01:29:56,600 --> 01:29:57,520 HAVE DEVELOPED INFRASTRUCTURE 2237 01:29:57,520 --> 01:29:59,880 FOR START GETTING TARGET TISSUE 2238 01:29:59,880 --> 01:30:02,560 FOR RESEARCH. 2239 01:30:02,560 --> 01:30:05,640 THE TISSUE IS CRITICAL IT IS 2240 01:30:05,640 --> 01:30:08,440 VERY DIFFERENT FOR TISSUE 2241 01:30:08,440 --> 01:30:11,240 INFORMED AND WE'RE ABLE TO RIDE 2242 01:30:11,240 --> 01:30:17,240 THE WAVY MERGING TECHNOLOGIES 2243 01:30:17,240 --> 01:30:20,520 AND WE WILL AND FROM DIFFERENT 2244 01:30:20,520 --> 01:30:27,400 TYPE OF TECHNOLOGIES NO SINGLE 2245 01:30:27,400 --> 01:30:37,840 AN IS THE SEES NOW WE HAVE 2246 01:30:39,400 --> 01:30:41,800 LAUNCHED LUPUS PROJECT CALLED 2247 01:30:41,800 --> 01:30:43,360 AMP AIM, THE AUTOIMMUNE AND 2248 01:30:43,360 --> 01:30:47,480 MEDIA DISEASES AND THIS IS BEEN 2249 01:30:47,480 --> 01:30:51,520 WITH NIDCR AND THEY'RE TER 2250 01:30:51,520 --> 01:30:54,120 TERRIFIC PARTNER SO THE FOCUS 2251 01:30:54,120 --> 01:30:55,520 WAS ON DECONSTRUCTION OF TAKING 2252 01:30:55,520 --> 01:30:57,400 THIS TISSUE, PULLING THE CELLS 2253 01:30:57,400 --> 01:30:59,640 OUT AND ANALYZING THE CELLS IN 2254 01:30:59,640 --> 01:31:01,840 ISOLATION AND THE FOCUS OF AMP 2255 01:31:01,840 --> 01:31:04,440 AIM WILL BE DISEASE 2256 01:31:04,440 --> 01:31:05,480 RECONSTRUCTION, IN OTHER WORDS, 2257 01:31:05,480 --> 01:31:06,680 WE KNOW WHO THE PLAYERS ARE BUT 2258 01:31:06,680 --> 01:31:08,600 WE NEED TO KNOW HOW THEY 2259 01:31:08,600 --> 01:31:10,680 INTERACT TO PUT THE PIECES BACK 2260 01:31:10,680 --> 01:31:12,320 TOGETHER AGAIN AND USING THE 2261 01:31:12,320 --> 01:31:17,440 EMERGING INSIGHTS AND 2262 01:31:17,440 --> 01:31:18,280 TECHNOLOGIES, NEXT SLIDE. 2263 01:31:18,280 --> 01:31:28,800 THIS WAS LAUNCHED A YEAR AGO AND 2264 01:31:40,200 --> 01:31:42,840 AND WE'VE GONE BEYOND THE 2265 01:31:42,840 --> 01:31:44,880 STUDIES OF ART IN LUPUS TO 2266 01:31:44,880 --> 01:31:49,680 INCLUDES PSORIASIS AND THIS IS 2267 01:31:49,680 --> 01:31:56,280 WHERE THE PARTNERSHIP HAS COME 2268 01:31:56,280 --> 01:32:06,360 IN. 2269 01:32:11,200 --> 01:32:13,400 REALLY IMPORTANT COMING OUT THE 2270 01:32:13,400 --> 01:32:14,920 R.A. AND LUPUS STUDIES IS 2271 01:32:14,920 --> 01:32:16,880 AMAZING HOW HETERO GENIOUS THE 2272 01:32:16,880 --> 01:32:19,160 TISSUES ARE IN A SINGLE 2273 01:32:19,160 --> 01:32:20,360 DIAGNOSIS. 2274 01:32:20,360 --> 01:32:21,080 THEY'RE ACTUALLY NEIGHBORHOODS 2275 01:32:21,080 --> 01:32:22,480 WITHIN TISSUE AND VERY DIFFERENT 2276 01:32:22,480 --> 01:32:23,560 PATHOLOGIES GOING ON. 2277 01:32:23,560 --> 01:32:25,480 SO, WE HAVE TO ACTUALLY ALMOST 2278 01:32:25,480 --> 01:32:27,480 RETHINK THESE DISEASES. 2279 01:32:27,480 --> 01:32:30,120 WE NEED TO UNDERSTAND HOW THE 2280 01:32:30,120 --> 01:32:33,600 CELL AND MOLECULAR PATH ARE 2281 01:32:33,600 --> 01:32:35,360 SPECIFIC TO A GIVEN DISEASE OR 2282 01:32:35,360 --> 01:32:41,320 COMMON ACROSS DISEASES. 2283 01:32:41,320 --> 01:32:42,160 DELIVERABLES ARE UNDERSTAND HOW 2284 01:32:42,160 --> 01:32:45,200 CELL CELL INTERACTIONS NEED TO 2285 01:32:45,200 --> 01:32:46,840 DISEASE THROUGH SPACIAL ANALYSIS 2286 01:32:46,840 --> 01:32:48,040 AND GOING BEYOND THAT TO 2287 01:32:48,040 --> 01:32:50,280 UNDERSTAND THE MEDIATORS THAT 2288 01:32:50,280 --> 01:32:52,040 THE CELLS USE TO TALK BETWEEN 2289 01:32:52,040 --> 01:32:53,120 THEMSELVES AND THEN INTEGRATE 2290 01:32:53,120 --> 01:32:55,760 ALL OF THAT WITH THE SYSTEMS 2291 01:32:55,760 --> 01:32:57,080 BIOLOGY APPROACH TO INTEGRATE 2292 01:32:57,080 --> 01:32:58,440 WHAT IS GOING ON IN THE TISSUES 2293 01:32:58,440 --> 01:33:00,160 WITH THE GENOMICS OF THE PERSON 2294 01:33:00,160 --> 01:33:02,920 AND THE EP GENETICS TO IDENTIFY 2295 01:33:02,920 --> 01:33:04,920 NEW TARGET MOLECULES CAUSE TIVE 2296 01:33:04,920 --> 01:33:15,400 FOR THE DISEASES, NEXT SLIDE. 2297 01:33:16,800 --> 01:33:19,080 THIS FOCUSED ON MOLECULAR 2298 01:33:19,080 --> 01:33:19,440 PATHWAYS. 2299 01:33:19,440 --> 01:33:21,000 YOU START WITH THE PERSON. 2300 01:33:21,000 --> 01:33:21,640 THE PERSON OF COURSE BRIDGES THE 2301 01:33:21,640 --> 01:33:23,240 AGAIN ET STICKS THAT THEY HAVE. 2302 01:33:23,240 --> 01:33:29,560 BASED ON THE INTERACTIONS OF THE 2303 01:33:29,560 --> 01:33:33,800 DISEASES, GENETIC DISEASE 2304 01:33:33,800 --> 01:33:36,640 ACTUALLY ARE EQTLs THEY MODIFY 2305 01:33:36,640 --> 01:33:39,120 THROUGH CHANGING EPI GENETIC 2306 01:33:39,120 --> 01:33:40,160 REGULATIONS AND SO BETWEEN THE 2307 01:33:40,160 --> 01:33:41,720 GENES AND THE ENVIRONMENT AND 2308 01:33:41,720 --> 01:33:44,080 THE MICROBIOME, THEY'RE CHANGES 2309 01:33:44,080 --> 01:33:46,920 IN THE EP DEGENETICS THAT LEAD 2310 01:33:46,920 --> 01:33:48,200 WHAT GETS TRANCE DESCRIBED 2311 01:33:48,200 --> 01:33:52,000 INSIDE THE CELLS AND THAT IS THE 2312 01:33:52,000 --> 01:33:53,320 THEY DICTATE WHICH PROTEINS GET 2313 01:33:53,320 --> 01:33:55,840 PRESSED AND WHAT THE SELL STATE 2314 01:33:55,840 --> 01:33:58,640 IS OF THE CELLS AND ALSO THE 2315 01:33:58,640 --> 01:34:00,040 MOLECULES THAT CELLS USE TO TALK 2316 01:34:00,040 --> 01:34:01,840 BETWEEN EACH OTHER AND THEN YOU 2317 01:34:01,840 --> 01:34:02,760 CAN USE SILLS TOMORROW'S BIOLOGY 2318 01:34:02,760 --> 01:34:04,080 APPROACH TO INTEGRATE ALL OF 2319 01:34:04,080 --> 01:34:05,880 THOSE THINGS TO HELP UNDERSTAND 2320 01:34:05,880 --> 01:34:08,120 DISEASE PHENOTYPES AND OUTCOMES 2321 01:34:08,120 --> 01:34:15,720 AND ALSO ASSOCIATED WITH BIO 2322 01:34:15,720 --> 01:34:16,480 MARK SOURCE YOU CAN UNDERSTAND 2323 01:34:16,480 --> 01:34:18,240 WHAT IS A PERSONS TISSUE BASED 2324 01:34:18,240 --> 01:34:22,240 ON THE READILY ACCESSIBLE 2325 01:34:22,240 --> 01:34:22,880 BIOMARKER. 2326 01:34:22,880 --> 01:34:23,640 IMPORTANT POINT THOUGH IS EACH 2327 01:34:23,640 --> 01:34:28,000 ONE OF THESE BOXES CAN BE 2328 01:34:28,000 --> 01:34:30,720 QUANTIFIED AND IN SOME DAYS AND 2329 01:34:30,720 --> 01:34:32,840 CELLS AND IF I HAD THE SAME CELL 2330 01:34:32,840 --> 01:34:35,480 IN THE SAME PERSON SO WE CAN NOW 2331 01:34:35,480 --> 01:34:37,520 INTEGRATE ACROSS THESE DIFFERENT 2332 01:34:37,520 --> 01:34:39,080 DOMAINS TO UNDERSTAND THE 2333 01:34:39,080 --> 01:34:45,720 MOLECULAR PATHWAYS THAT DRIVE 2334 01:34:45,720 --> 01:34:46,120 BIOLOGY. 2335 01:34:46,120 --> 01:34:50,320 IF LUPUS WAS ON THE LEFT SIDE, 2336 01:34:50,320 --> 01:35:00,840 FOCUSED ON THE CELLS USE TO TALK 2337 01:35:02,600 --> 01:35:06,720 TO EACH OTHER. 2338 01:35:06,720 --> 01:35:07,920 AND THIS DATA WILL BE AVAILABLE 2339 01:35:07,920 --> 01:35:10,760 IN A PORTAL THAT STOOD UP NOW 2340 01:35:10,760 --> 01:35:12,360 AND IT'S ACCESSIBLE TO THE 2341 01:35:12,360 --> 01:35:22,800 MEMBERS OF THE NETWORK AND 2342 01:35:27,600 --> 01:35:28,600 RESEARCH IS CONTROLLED ACCESS 2343 01:35:28,600 --> 01:35:31,560 AND THEY CAN INTEG GATE THE 2344 01:35:31,560 --> 01:35:34,960 POPULATION INTEREST AND -- 2345 01:35:34,960 --> 01:35:38,720 THE GENES AND THE MOLECULES AND 2346 01:35:38,720 --> 01:35:43,440 IT SETS US UP FOR THE FUTURE. 2347 01:35:43,440 --> 01:35:48,400 NEXT SLIDE. 2348 01:35:48,400 --> 01:35:50,280 THIS CREATING DATA ECOSYSTEM 2349 01:35:50,280 --> 01:35:51,920 THAT NO ONE PERSON FILLS IN 2350 01:35:51,920 --> 01:35:53,080 THOSE BOXES BY THEMSELVES. 2351 01:35:53,080 --> 01:35:54,880 WE HAVE TO HAVE A DIFFERENT 2352 01:35:54,880 --> 01:35:59,560 EXPERTISE BROUGHT TOGETHER. 2353 01:35:59,560 --> 01:36:01,800 THEY CAN GO ON OUTSIDE AND THE 2354 01:36:01,800 --> 01:36:03,680 BEHAVIOR AND PSYCHOSOCIAL 2355 01:36:03,680 --> 01:36:05,200 INTERACTIONS AND IT TAKES THE 2356 01:36:05,200 --> 01:36:06,520 INTEGRATION ACROSS RESEARCH 2357 01:36:06,520 --> 01:36:09,240 TEAMS AND ACROSS ANALYTIC 2358 01:36:09,240 --> 01:36:11,240 PLATFORMS AND ACROSS DISEASES AS 2359 01:36:11,240 --> 01:36:14,240 I MENTIONED AND ACROSS AND 2360 01:36:14,240 --> 01:36:16,600 INSTITUTES AND CENTERS AND I 2361 01:36:16,600 --> 01:36:18,040 THINK NIH HAS TO MOVE AWAY FROM 2362 01:36:18,040 --> 01:36:22,960 THE SILOED APPROACH TO DISEASES 2363 01:36:22,960 --> 01:36:33,480 AND THINKING THIS THE SYSTEMS 2364 01:36:36,120 --> 01:36:37,000 BIOLOGY INFORMATION WHICH WE'RE 2365 01:36:37,000 --> 01:36:38,720 TRYING TO LAUNCH IS A NEW AMP 2366 01:36:38,720 --> 01:36:40,200 PROJECT FROM A CONCEPT 2367 01:36:40,200 --> 01:36:42,440 PRESENTATION BY SUSAN AND MYSELF 2368 01:36:42,440 --> 01:36:44,440 AND THROUGH THE AMP EXECUTIVE 2369 01:36:44,440 --> 01:36:45,680 COMMITTEE. 2370 01:36:45,680 --> 01:36:48,160 NEXT SLIDE. 2371 01:36:48,160 --> 01:36:49,680 SO, WHAT IT DOES IS TAKE ALL THE 2372 01:36:49,680 --> 01:36:51,200 DIFFERENT AMP PROJECTS AND ALL 2373 01:36:51,200 --> 01:36:54,160 BUT ONE OF THEM HAVE OMIC DATA 2374 01:36:54,160 --> 01:36:55,600 OF SOME SORT AND TRIED TO 2375 01:36:55,600 --> 01:36:57,280 INTEGRATE ACROSS SOME VERY 2376 01:36:57,280 --> 01:36:59,040 DIFFERENT DISEASES AND SO 2377 01:36:59,040 --> 01:37:02,200 DISEASES THAT WE USED TO THINK 2378 01:37:02,200 --> 01:37:05,000 AND IT'S COMPLETELY SEPARATE AND 2379 01:37:05,000 --> 01:37:06,760 ALL REST ON THE SAME SUBSTRATE, 2380 01:37:06,760 --> 01:37:08,200 WE KNOW THAT BECAUSE EVERYTHING 2381 01:37:08,200 --> 01:37:10,560 IS BASED ON OUR OWN GENOMES AND 2382 01:37:10,560 --> 01:37:12,440 THERE ARE QUITE SIMILAR PATHWAYS 2383 01:37:12,440 --> 01:37:13,920 ACTIVE IN DISEASES THAT YOU 2384 01:37:13,920 --> 01:37:15,800 WOULD NEVER THOUGHT OF THE SAME. 2385 01:37:15,800 --> 01:37:17,520 WE CAN FIND SIMILARITIES AND 2386 01:37:17,520 --> 01:37:19,960 FLAM TORI PATHWAYS BETWEEN 2387 01:37:19,960 --> 01:37:21,520 ALZHEIMER'S DISEASE AND 2388 01:37:21,520 --> 01:37:23,880 PARKINSON'S, RHUMATOID ARTHRITIS 2389 01:37:23,880 --> 01:37:24,360 AND LUPUS. 2390 01:37:24,360 --> 01:37:25,880 SO, IT'S A NEW WAY OF 2391 01:37:25,880 --> 01:37:33,960 APPROACHING THESE DISEASES. 2392 01:37:33,960 --> 01:37:36,120 SO WHAT IT WOULD DO IS TAKE THE 2393 01:37:36,120 --> 01:37:37,240 EXISTING DATASETS PRODUCED IN 2394 01:37:37,240 --> 01:37:39,160 ALL THE DIFFERENT AMP PROJECTS 2395 01:37:39,160 --> 01:37:42,480 AND USE THOSE TO INTEGRATE 2396 01:37:42,480 --> 01:37:45,640 ACROSS THE DISEASES USING LENS 2397 01:37:45,640 --> 01:37:47,320 OF INFLAMMATION AND SO THEY CAN 2398 01:37:47,320 --> 01:37:49,280 WE CAN DO DRUG DEVELOPMENT IN 2399 01:37:49,280 --> 01:37:50,520 POSITIONING OF DRUGS BASED ON 2400 01:37:50,520 --> 01:37:52,680 THE MECHANISM OF ACTIVE AND AN 2401 01:37:52,680 --> 01:37:54,240 INDIVIDUAL AND NOT ACCORDING TO 2402 01:37:54,240 --> 01:37:56,880 THE CLINICAL LABEL. 2403 01:37:56,880 --> 01:37:58,280 WE CAN USE BLOOD OMICS DATA TO 2404 01:37:58,280 --> 01:38:00,040 LOOK AT HOW THE SYSTEMIC 2405 01:38:00,040 --> 01:38:01,680 INFLAMMATION RELATES TO WHAT 2406 01:38:01,680 --> 01:38:03,760 HAPPENS IN TISSUES AND WE CAN 2407 01:38:03,760 --> 01:38:05,520 UNDERSTAND THE CONTRIBUTION OF 2408 01:38:05,520 --> 01:38:10,600 CHRONIC FROM MISSCRON INFLAMMATS 2409 01:38:10,600 --> 01:38:12,680 DISEASES AND NEXT -- AT THE END 2410 01:38:12,680 --> 01:38:14,760 OF THE DAY, WHAT WE WANT TO DO 2411 01:38:14,760 --> 01:38:17,640 IS DEVELOP A MOLECULAR TAXONOMY 2412 01:38:17,640 --> 01:38:19,920 OF DISEASE TO DRIVE TREATMENTS 2413 01:38:19,920 --> 01:38:22,360 BASED ON ACTIVE PATHWAYS IN A 2414 01:38:22,360 --> 01:38:23,760 GIVEN PATIENT REGARDLESS OF THE 2415 01:38:23,760 --> 01:38:24,880 CLINICAL DIAGNOSIS. 2416 01:38:24,880 --> 01:38:27,960 SO THAT IS THE BIG ASK AND WE 2417 01:38:27,960 --> 01:38:29,080 HOPE THAT NIDCR WILL JOIN US IN 2418 01:38:29,080 --> 01:38:32,960 THIS JOURNEY. 2419 01:38:32,960 --> 01:38:34,720 NEXT SLIDE. 2420 01:38:34,720 --> 01:38:37,320 THIS IS NOT PIE IN THE SKY THIS 2421 01:38:37,320 --> 01:38:38,880 IS THE LUPUS INVESTIGATORS WHO 2422 01:38:38,880 --> 01:38:40,400 CAN DEMONSTRATE A SIMILAR TYPE 2423 01:38:40,400 --> 01:38:43,640 OF MACROPHAGE ACROSS A RANGE OF 2424 01:38:43,640 --> 01:38:45,640 NOT JUST AUTOIMMUNE DISEASES BUT 2425 01:38:45,640 --> 01:38:47,320 EVEN IN COVID SO THIS TYPE OF 2426 01:38:47,320 --> 01:38:49,200 THING IS POSSIBLE AND IT IS 2427 01:38:49,200 --> 01:38:51,800 HAPPENING AND I THINK WE NEED 2428 01:38:51,800 --> 01:38:55,040 NIH JOINED TOGETHER ACROSS ICs 2429 01:38:55,040 --> 01:38:57,440 TO MOVE THIS APPROACH DISEASE 2430 01:38:57,440 --> 01:39:04,280 BEFORE AND THIS IS THE NEXT 2431 01:39:04,280 --> 01:39:09,720 SLIDE. 2432 01:39:09,720 --> 01:39:10,440 NEXT SLIDE. 2433 01:39:10,440 --> 01:39:16,400 SO WE HAVE A LOT TO TALK ABOUT 2434 01:39:16,400 --> 01:39:24,440 BETWEEN NIDCR AND HOW DOES PERRY 2435 01:39:24,440 --> 01:39:26,960 PER -- HOW DOES OSTEO ARTHRITIS 2436 01:39:26,960 --> 01:39:29,080 RESPOND TO REGENERATION. 2437 01:39:29,080 --> 01:39:31,440 SO THANK YOU FOR YOUR ATTENTION 2438 01:39:31,440 --> 01:39:32,880 AND I HOPE TO ANSWER ANY 2439 01:39:32,880 --> 01:39:34,200 QUESTIONS AND HOPE WE CAN 2440 01:39:34,200 --> 01:39:37,840 CONTINUE TO WORK TOGETHER. 2441 01:39:37,840 --> 01:39:44,720 THANK YOU. 2442 01:39:44,720 --> 01:39:45,720 >> THANK YOU, VERY MUCH. 2443 01:39:45,720 --> 01:39:46,720 THAT WAS AMAZING. 2444 01:39:46,720 --> 01:39:48,520 ARE THERE QUESTIONS FOR Dr. 2445 01:39:48,520 --> 01:39:48,760 CARTER. 2446 01:39:48,760 --> 01:39:51,800 >> THAT WAS SUCH A BROAD SWEEP 2447 01:39:51,800 --> 01:39:53,800 OF IN-DEPTH WORK. 2448 01:39:53,800 --> 01:39:57,560 CAN YOU TALK ABOUT THE 2449 01:39:57,560 --> 01:39:58,800 THERAPEUTICS THAT THIS WORK 2450 01:39:58,800 --> 01:39:59,960 ACTUALLY GAVE RISE TO, 2451 01:39:59,960 --> 01:40:04,440 ESPECIALLY FOR SYSTEMIC LUPUS 2452 01:40:04,440 --> 01:40:07,560 AND RHUMATOID ARTHRITIS? 2453 01:40:07,560 --> 01:40:08,560 >> THERE'S ARE A COUPLE THINGS 2454 01:40:08,560 --> 01:40:09,280 IN THE WORKS. 2455 01:40:09,280 --> 01:40:11,680 I'M GOING TO DIGRESS TO MAKE THE 2456 01:40:11,680 --> 01:40:12,880 POINT BECAUSE THERE ARE SEVERAL 2457 01:40:12,880 --> 01:40:15,200 THINGS WRAPPED UP IN THAT BUT WE 2458 01:40:15,200 --> 01:40:17,160 ALWAYS THOUGHT OF RA AS AN 2459 01:40:17,160 --> 01:40:19,120 EXPANSION OF A SET OF CELLS THAT 2460 01:40:19,120 --> 01:40:23,760 ARE ON THE OUTSIDE OF THE SLOGAN 2461 01:40:23,760 --> 01:40:25,280 LINING CELLS AND WHEN WE FOUND 2462 01:40:25,280 --> 01:40:26,760 WAS THAT ACTUALLY IT WASN'T 2463 01:40:26,760 --> 01:40:30,600 THOSE CELLS, THERE WAS A 2464 01:40:30,600 --> 01:40:33,600 DIFFERENT TYPE OF FIBREGLASS 2465 01:40:33,600 --> 01:40:36,240 UNDER THE LINING AND THOSE CELLS 2466 01:40:36,240 --> 01:40:36,520 EXPANDED. 2467 01:40:36,520 --> 01:40:37,800 THEY WERE THIGH ONE POSITIVE AND 2468 01:40:37,800 --> 01:40:40,720 DIFFERENT SET OF CELLS AND RARE 2469 01:40:40,720 --> 01:40:42,120 IN NORMAL PEOPLE WITHOUT 2470 01:40:42,120 --> 01:40:42,560 ARTHRITIS. 2471 01:40:42,560 --> 01:40:44,640 AND WHAT WE COULD DO EVENTUALLY 2472 01:40:44,640 --> 01:40:47,040 THE GROUP AT BRIGHAM MAPPED 2473 01:40:47,040 --> 01:40:48,800 THOSE TWO IN INTERACTION WITH 2474 01:40:48,800 --> 01:40:52,440 BLOOD STRESS VESSEL AND THOUGH 2475 01:40:52,440 --> 01:40:56,320 THE EXPANSION OF THE SUB LINING 2476 01:40:56,320 --> 01:40:58,080 FIBER BLAST AND IT CORRELATED 2477 01:40:58,080 --> 01:41:05,560 WITH DISEASE OUTCOMES AND 2478 01:41:05,560 --> 01:41:07,160 SEVERITY. 2479 01:41:07,160 --> 01:41:08,240 THEY WERE DEVELOPED FOR CANCER 2480 01:41:08,240 --> 01:41:09,920 AND I'M NOT PRIVY TO EXACTLY 2481 01:41:09,920 --> 01:41:11,440 WHAT IS GOING THERE BECAUSE 2482 01:41:11,440 --> 01:41:13,120 EVERYTHING WE DO IS PRE 2483 01:41:13,120 --> 01:41:14,320 COMPETITIVE BUT IT'S NOW OPENING 2484 01:41:14,320 --> 01:41:16,360 UP A NEW WINDOW HOW TO TREAT IT 2485 01:41:16,360 --> 01:41:21,600 AND THE OTHER SIDE OF THE THINGS 2486 01:41:21,600 --> 01:41:22,760 THE DRUG COMPANIES ARE NOT 2487 01:41:22,760 --> 01:41:25,720 WORKING ON AND THEY'RE NOT VERY 2488 01:41:25,720 --> 01:41:29,280 RARE AND RHUMATOID. 2489 01:41:29,280 --> 01:41:32,000 MOUSE MODELS, THINGS LIKE IL17 2490 01:41:32,000 --> 01:41:34,760 GET PRESS BECAUSE THEY COME OUT 2491 01:41:34,760 --> 01:41:37,680 OF MOUSE MODELS AND LITTLE IL17 2492 01:41:37,680 --> 01:41:39,600 MANY OF THERE'S SOME BUT FEW. 2493 01:41:39,600 --> 01:41:42,440 ACTUALLY IF YOU ASK THE INDUSTRY 2494 01:41:42,440 --> 01:41:43,840 THE WIG BIGGEST THING AND 2495 01:41:43,840 --> 01:41:48,880 THEY'VE STOPPED THE NUMBER OF 2496 01:41:48,880 --> 01:41:50,040 DRUG PROTOCOL DEVELOPMENT 2497 01:41:50,040 --> 01:41:51,240 BECAUSE THERE WASN'T EVIDENCE 2498 01:41:51,240 --> 01:41:56,240 AND I THINK YOU KNOW, A LOT OF 2499 01:41:56,240 --> 01:41:59,520 TIMES THINGS GET THINGS AS 2500 01:41:59,520 --> 01:42:00,960 FISHING EXPEDITIONS AND IF YOU 2501 01:42:00,960 --> 01:42:03,160 DID KNOW THE PLAYERS, HOW CAN 2502 01:42:03,160 --> 01:42:05,040 YOU COME UP WITH EFFECTIVE 2503 01:42:05,040 --> 01:42:06,160 TREATMENT AND THIS DISCOVERY 2504 01:42:06,160 --> 01:42:07,520 THING WHERE YOU PRODUCE A 2505 01:42:07,520 --> 01:42:08,960 DATASET AND THERE'S ONE OTHER 2506 01:42:08,960 --> 01:42:10,160 SITUATION WHERE SOMEONE WAS 2507 01:42:10,160 --> 01:42:11,800 WORKING ON A GENE AND A MOUSE 2508 01:42:11,800 --> 01:42:13,000 MODEL BUT DIDN'T KNOW RELEVANCE 2509 01:42:13,000 --> 01:42:16,320 BUT WENT IN AND FOUND IT PRESENT 2510 01:42:16,320 --> 01:42:18,000 IN LUPUS KIDNEY, COULD SHOW IT 2511 01:42:18,000 --> 01:42:19,520 IN THE CERTAIN TYPE OF CELL 2512 01:42:19,520 --> 01:42:20,960 WHICH MATCHED THEIR HYPOTHESIS 2513 01:42:20,960 --> 01:42:22,400 FROM THEIR MOUSE WORK AND GOT 2514 01:42:22,400 --> 01:42:26,720 HIS RO1 FUNDED. 2515 01:42:26,720 --> 01:42:28,040 SO, THERE'S AN IMPACT ALTHOUGH 2516 01:42:28,040 --> 01:42:31,320 IN TERMS OF NEW THERAPY, THERE'S 2517 01:42:31,320 --> 01:42:33,120 NONE THAT HAVE GOTTEN ACROSS THE 2518 01:42:33,120 --> 01:42:36,240 FINISH LINE YET. 2519 01:42:36,240 --> 01:42:40,960 >> ANY OTHER QUESTIONS? 2520 01:42:40,960 --> 01:42:42,840 >> THIS IS VERY EXCITING. 2521 01:42:42,840 --> 01:42:44,000 THANK YOU SO MUCH. 2522 01:42:44,000 --> 01:42:45,560 ACROSS THIS NEW INITIATIVE, THIS 2523 01:42:45,560 --> 01:42:47,080 CROSS CUTTING INITIATIVE WHERE 2524 01:42:47,080 --> 01:42:52,000 YOU ARE GOING TO LOOK AT THE 2525 01:42:52,000 --> 01:42:53,640 COMMONALITY WITHIN THE CHRONIC 2526 01:42:53,640 --> 01:42:55,080 INFLAMMATION, IT WOULD BE VERY 2527 01:42:55,080 --> 01:43:00,240 INTERESTING TO LOOK AT THE ROLE 2528 01:43:00,240 --> 01:43:05,760 OF PERRY DON TAL DISEASE BECAUSE 2529 01:43:05,760 --> 01:43:09,480 THEY HAVE THIS CHRONIC 2530 01:43:09,480 --> 01:43:20,000 INFLAMMATION AND TO -- AND IT'S 2531 01:43:26,760 --> 01:43:27,960 MAKING SYSTEMIC CONTRIBUTION AND 2532 01:43:27,960 --> 01:43:29,880 I WANTED TO SHARE THE POTENTIAL 2533 01:43:29,880 --> 01:43:30,520 FOR COLLABORATION. 2534 01:43:30,520 --> 01:43:32,360 >> THANK YOU, I AGREE. 2535 01:43:32,360 --> 01:43:37,080 >> ALSO, COUNTING ON YOUR 2536 01:43:37,080 --> 01:43:39,440 EXPERIENCES TO HELP US WITH THE 2537 01:43:39,440 --> 01:43:41,760 TMD WITH IMPACT BECAUSE WE HAVE 2538 01:43:41,760 --> 01:43:43,360 A CONDITION THAT HAS A GENDER 2539 01:43:43,360 --> 01:43:45,960 BIAS SO THAT'S THE FIRST UNIQUE 2540 01:43:45,960 --> 01:43:46,320 THING. 2541 01:43:46,320 --> 01:43:47,840 THE JOINT ITSELF IS UNIQUE AND 2542 01:43:47,840 --> 01:43:50,320 THE FIBER CARTILAGE ELEMENTS AND 2543 01:43:50,320 --> 01:43:51,840 IT'S ALSO UNIQUE BECAUSE WE PUT 2544 01:43:51,840 --> 01:43:53,240 MAXIMUM AMOUNT OF STRESS ON IT 2545 01:43:53,240 --> 01:43:56,480 AS COMPARED TO KNEE AND HIP. 2546 01:43:56,480 --> 01:44:00,640 BUT THEN YOU HAVE A BUY BIO 2547 01:44:00,640 --> 01:44:02,160 CYCLE SOCIAL ELEMENT. 2548 01:44:02,160 --> 01:44:03,640 WHICH COMES FIRST? 2549 01:44:03,640 --> 01:44:06,360 DOES THAT STRESS CAUSE TMD OR IS 2550 01:44:06,360 --> 01:44:09,080 THE CLINCHING GOING TO AGGRAVATE 2551 01:44:09,080 --> 01:44:10,280 AN EXISTING CONDITION. 2552 01:44:10,280 --> 01:44:12,120 HOW DOES ONE DISSECT OUT THIS 2553 01:44:12,120 --> 01:44:12,320 LOOP? 2554 01:44:12,320 --> 01:44:14,320 IS IT A FEEDBACK LOOP? 2555 01:44:14,320 --> 01:44:18,960 WHAT IS PRIMARY AND IT'S ALL 2556 01:44:18,960 --> 01:44:20,160 DIFFICULT BECAUSE WE HAVE THIS 2557 01:44:20,160 --> 01:44:24,920 BIO CYCLE SOCIAL AGENDA BIAS OF 2558 01:44:24,920 --> 01:44:27,520 THE AGENDA BASE FOR DIFFERENCES. 2559 01:44:27,520 --> 01:44:30,240 >> I AGREE. 2560 01:44:30,240 --> 01:44:34,040 THE CAUSAL INFERENCE IS A 2561 01:44:34,040 --> 01:44:34,560 PROBLEM. 2562 01:44:34,560 --> 01:44:37,360 STATISTICS AROUND IT ARE TOUGH. 2563 01:44:37,360 --> 01:44:39,640 AND IT JUST GOES TO THE 2564 01:44:39,640 --> 01:44:40,800 CONFOUNDERS ARE SO TOUGH. 2565 01:44:40,800 --> 01:44:45,720 I DO THINK THAT YOU CAN USE AI 2566 01:44:45,720 --> 01:44:47,280 TO UNDERSTAND PATHWAYS THAT YOU 2567 01:44:47,280 --> 01:44:49,640 WOULD NOT SUSPECTED BEFORE. 2568 01:44:49,640 --> 01:44:52,920 AND I THINK THAT'S THE HOPE 2569 01:44:52,920 --> 01:44:54,480 THAT, IN SOME CASES, THINGS ARE 2570 01:44:54,480 --> 01:44:56,800 JUST SO ENTANGLED BUT IN OTHER 2571 01:44:56,800 --> 01:45:00,440 CASES, BY UNDERSTANDING THE LINK 2572 01:45:00,440 --> 01:45:04,240 TO THE BIO PSYCHOSOCIAL TO THE 2573 01:45:04,240 --> 01:45:06,880 SYMPTOMS AND TO THE MOLECULAR 2574 01:45:06,880 --> 01:45:08,320 PATHWAYS, AT THAT POINT I THINK 2575 01:45:08,320 --> 01:45:11,240 CAN YOU START TO AT LEAST COME 2576 01:45:11,240 --> 01:45:13,280 UP WITH HYPOTHESIS OF CAUSE TIVE 2577 01:45:13,280 --> 01:45:18,360 AND MECHANISMS. 2578 01:45:18,360 --> 01:45:18,920 >> Lynn M. King: GREAT. 2579 01:45:18,920 --> 01:45:19,320 THANK YOU. 2580 01:45:19,320 --> 01:45:20,960 I THINK WE NEED TO MOVE ON TO 2581 01:45:20,960 --> 01:45:23,800 OUR NEXT SPEAKER. 2582 01:45:23,800 --> 01:45:26,160 Mr. AXLE VISEL. 2583 01:45:26,160 --> 01:45:31,600 HE IS A COUPLE ME COUNCILMEMBERR 2584 01:45:31,600 --> 01:45:32,920 OF THE DATA SCIENCE WORKING 2585 01:45:32,920 --> 01:45:34,920 GROUP WHICH RONA PRESENT TODAY 2586 01:45:34,920 --> 01:45:36,040 COUNCIL BACK IN JANUARY AND MAY 2587 01:45:36,040 --> 01:45:40,200 OF THIS YEAR. 2588 01:45:40,200 --> 01:45:44,040 I'M GOING TO TURN IT OVER TO 2589 01:45:44,040 --> 01:45:46,520 Dr. VISEL WHO PROVIDE AN 2590 01:45:46,520 --> 01:45:50,960 UPDATE AND STATUS OF THIS 2591 01:45:50,960 --> 01:45:51,320 WORKING GROUP. 2592 01:45:51,320 --> 01:46:01,800 >> WE'RE WAITING TO SEE YOUR 2593 01:46:20,640 --> 01:46:21,440 SLIDES, AXEL. 2594 01:46:21,440 --> 01:46:25,000 OR WOULD YOU LIKE NIDCR TO 2595 01:46:25,000 --> 01:46:35,160 PRESENT? 2596 01:46:38,240 --> 01:46:39,840 SHOULD WE MOVE DANA UP FOR NOW 2597 01:46:39,840 --> 01:46:43,560 OR JUST WAIT. 2598 01:46:43,560 --> 01:46:47,480 EITHER ONE. 2599 01:46:47,480 --> 01:46:48,720 HE HAS BEEN ON SO I DON'T KNOW 2600 01:46:48,720 --> 01:46:50,600 WHAT IS HAPPENING HERE. 2601 01:46:50,600 --> 01:46:52,680 >> WHEN WE WAIT, I WAS GOING TO 2602 01:46:52,680 --> 01:46:54,000 ASK DANA AND OTHERS BECAUSE YOU 2603 01:46:54,000 --> 01:46:56,680 KNOW AS JENNIFER MENTIONED, THE 2604 01:46:56,680 --> 01:46:57,960 APPLICATIONS ARE THERE. 2605 01:46:57,960 --> 01:47:01,040 >> GREAT. 2606 01:47:01,040 --> 01:47:03,280 >> TO PATIENTS. 2607 01:47:03,280 --> 01:47:05,480 >> YEAH. 2608 01:47:05,480 --> 01:47:08,280 MY COMPUTER JUST FROZE, RIGHT. 2609 01:47:08,280 --> 01:47:09,960 I STARTED MY PRESENTATION AND 2610 01:47:09,960 --> 01:47:14,000 DIDN'T DO ANYTHING FOR A MINUTE 2611 01:47:14,000 --> 01:47:24,120 OR SO. 2612 01:47:24,520 --> 01:47:30,040 I DID ADVANCE THE SLIDES. 2613 01:47:30,040 --> 01:47:30,840 EXTENT. 2614 01:47:30,840 --> 01:47:31,080 HOCKEY. 2615 01:47:31,080 --> 01:47:32,600 GOOD MORNING AND I'M IN THE MOOD 2616 01:47:32,600 --> 01:47:34,760 FOR MOST OF IT AT THAT POINT, 2617 01:47:34,760 --> 01:47:35,080 EVERYBODY. 2618 01:47:35,080 --> 01:47:37,760 SO I'M REALLY EXCITED TO GIVE 2619 01:47:37,760 --> 01:47:39,920 THIS UPDATE ABOUT THE DATA 2620 01:47:39,920 --> 01:47:42,280 SCIENCE STRATEGY WORKING GROUP. 2621 01:47:42,280 --> 01:47:45,920 MY NAME IS AXEL AND I'M AT 2622 01:47:45,920 --> 01:47:47,040 GEORGE BERKELEY NATIONAL LAB AND 2623 01:47:47,040 --> 01:47:48,880 I WAS APPOINTED AS THE CHAIR OF 2624 01:47:48,880 --> 01:47:59,640 THE WORKING GROUP AND REMINDING 2625 01:47:59,640 --> 01:48:01,360 EVERYBODY WHAT THESE COUNCIL 2626 01:48:01,360 --> 01:48:05,360 WORKING GROUPS ARE AND SO THESE 2627 01:48:05,360 --> 01:48:08,520 ARE GROUPS THAT ESSENTIALLY ARE 2628 01:48:08,520 --> 01:48:11,840 TASKED TO FOCUS ON A SPECIFIC 2629 01:48:11,840 --> 01:48:16,800 PROBABLE, A LIMITED PROJECT THT 2630 01:48:16,800 --> 01:48:18,600 I WOULD GET UNPUT ON SO THEY 2631 01:48:18,600 --> 01:48:20,800 SERVICE FACT-FINDING BODIES 2632 01:48:20,800 --> 01:48:24,560 BRINGING TOGETHER EXPERTS WITH 2633 01:48:24,560 --> 01:48:27,600 THE GOAL TO ASSESS THE FACT AND 2634 01:48:27,600 --> 01:48:29,080 PROVIDE RECOMMENDATIONS. 2635 01:48:29,080 --> 01:48:30,520 SOMETHING THAT IS IMPORTANT HERE 2636 01:48:30,520 --> 01:48:31,640 IS THESE ARE COUNCIL WORKING 2637 01:48:31,640 --> 01:48:33,480 GROUP SO THEY MAKE THEIR 2638 01:48:33,480 --> 01:48:36,160 RECOMMENDATIONS NOT DIRECTINGLY 2639 01:48:36,160 --> 01:48:37,920 TO NIDCR BUT TO COUNCIL AND IT 2640 01:48:37,920 --> 01:48:40,480 CAN THEN IN TURN USE THESE 2641 01:48:40,480 --> 01:48:44,480 RECOMMENDATION TO PROVIDE ADVICE 2642 01:48:44,480 --> 01:48:45,040 TO COUNCIL. 2643 01:48:45,040 --> 01:48:46,360 THERE ARE CURRENTLY THREE 2644 01:48:46,360 --> 01:48:47,920 COUNCIL WORKING GROUPS PLANNED 2645 01:48:47,920 --> 01:48:58,240 OR IN PROGRESS AND. 2646 01:50:12,240 --> 01:50:16,520 >> THESE APPROACHES HAVE TO BE 2647 01:50:16,520 --> 01:50:21,080 TRANSFORMATIVE IN MANY AREAS OF 2648 01:50:21,080 --> 01:50:23,200 SCIENCE THE KNOWN EXAMPLE THAT 2649 01:50:23,200 --> 01:50:24,960 GOT PRESS LAST YEAR THIS THIS 2650 01:50:24,960 --> 01:50:27,560 NEWS TO ALPHA PHOTOGRAPHIC 2651 01:50:27,560 --> 01:50:28,760 DEVELOPED UNDER THE GOOGLE 2652 01:50:28,760 --> 01:50:30,520 UMBRELLA AND A REVOLUTIONARY 2653 01:50:30,520 --> 01:50:34,440 TOOL THAT USED ARTIFICIAL 2654 01:50:34,440 --> 01:50:37,040 INTELLIGENCE TO GET SETS TO 2655 01:50:37,040 --> 01:50:39,040 ENABLE ACCURATE PREDICTIONS OF 2656 01:50:39,040 --> 01:50:40,760 C2 STRUCTURES FOR MANY PROTEINS 2657 01:50:40,760 --> 01:50:44,480 SO THIS IS SOMETHING THAT 2658 01:50:44,480 --> 01:50:46,080 STRUCTURAL BIOLOGIST HAVE BEEN 2659 01:50:46,080 --> 01:50:47,400 DREAMING OF FOR MANY DECADES 2660 01:50:47,400 --> 01:50:49,560 IT'S TRANSFORMATIVE AND CHANGING 2661 01:50:49,560 --> 01:50:50,720 AN ENTIRE FEET. 2662 01:50:50,720 --> 01:50:52,280 NOW THESE TERMS GET A LOT OF 2663 01:50:52,280 --> 01:50:53,680 PRESS BUT WHEN WE THINK ABOUT 2664 01:50:53,680 --> 01:50:56,600 DATA SCIENCE, AND THIS IS TRUE 2665 01:50:56,600 --> 01:50:58,640 FOR BOTH THE WAY OUR WORKING 2666 01:50:58,640 --> 01:51:00,760 GROUP THINKS ABOUT DATA SCIENCE 2667 01:51:00,760 --> 01:51:02,200 AND THE WAY NIDCR THINKS ABOUT 2668 01:51:02,200 --> 01:51:04,280 DATA SCIENCE IT'S IMPORTANT TO 2669 01:51:04,280 --> 01:51:06,320 ACKNOWLEDGE THERE'S MUCH MORE 2670 01:51:06,320 --> 01:51:08,280 THAN THESE FLASHY TERMS AND MANY 2671 01:51:08,280 --> 01:51:11,720 DATA SCIENCE AND DATA ENABLE 2672 01:51:11,720 --> 01:51:16,240 APPROACHES THAT ARE REALLY 2673 01:51:16,240 --> 01:51:17,800 IMPORTANT FOR ADVANCING THE 2674 01:51:17,800 --> 01:51:20,680 MISSION IN PARTICULAR AND SOME 2675 01:51:20,680 --> 01:51:22,000 EXAMPLES ARE SHOWN HERE ON THIS 2676 01:51:22,000 --> 01:51:22,920 SLIDE, RIGHT. 2677 01:51:22,920 --> 01:51:25,320 SO THIS INCLUDES THINGS SUCH AS 2678 01:51:25,320 --> 01:51:28,960 INTEGRATIVE DATA SYSTEMS AND I 2679 01:51:28,960 --> 01:51:30,160 THINK IN THE NIDCR SPACE IT'S 2680 01:51:30,160 --> 01:51:33,480 BEEN A SPECTACULARLY SUCCESSFUL 2681 01:51:33,480 --> 01:51:36,800 EXAMPLE OF THAT AND THE 2682 01:51:36,800 --> 01:51:39,600 DEVELOPMENT OF CONTROLLED FOR 2683 01:51:39,600 --> 01:51:40,640 VOCABULARY THAT DESCRIBE 2684 01:51:40,640 --> 01:51:42,800 BIOLOGICAL AND MEDICAL ENTITIES 2685 01:51:42,800 --> 01:51:45,600 SUCH AS GENES, ANATOMY AND 2686 01:51:45,600 --> 01:51:47,040 PHENOTYPES AND DIFFERENT ACCESS 2687 01:51:47,040 --> 01:51:51,120 TO THESE KINDS OF BIOLOGICAL 2688 01:51:51,120 --> 01:51:52,680 ENTITIES FOR DATA SCIENCE 2689 01:51:52,680 --> 01:51:56,080 APPROACHES AND AI READINESS AND 2690 01:51:56,080 --> 01:51:57,480 DATA ACCESS AND SHARING. 2691 01:51:57,480 --> 01:51:59,240 YOU MAY HAVE HEARD ABOUT THIS 2692 01:51:59,240 --> 01:52:01,240 PRINCIPLES THAT DESCRIBE HOW YOU 2693 01:52:01,240 --> 01:52:02,520 MAKE DATA FINE ABLE AND 2694 01:52:02,520 --> 01:52:09,800 ACCESSIBLE AND SO ON SO THEY CAN 2695 01:52:09,800 --> 01:52:11,000 REUSE DAYTONA AND IT'S REALLY 2696 01:52:11,000 --> 01:52:14,000 HARD TO DO SO AND SO DATA 2697 01:52:14,000 --> 01:52:15,320 ECOSYSTEMS FOR RESEARCH AND 2698 01:52:15,320 --> 01:52:19,600 TRAINING THESE ARE INCREASING IN 2699 01:52:19,600 --> 01:52:21,600 IMPORTANCE AND DIFFICULT TO 2700 01:52:21,600 --> 01:52:22,880 BUILD AND THEN WHEN WE THINK 2701 01:52:22,880 --> 01:52:26,000 ABOUT THE CLINICAL SIDE, 2702 01:52:26,000 --> 01:52:28,760 ELECTRONIC CLINICAL RECORDS THAT 2703 01:52:28,760 --> 01:52:31,000 ARE IMPORTANT FOR IMPROVING 2704 01:52:31,000 --> 01:52:33,960 HEALTHCARE BUT ALSO FOR USING 2705 01:52:33,960 --> 01:52:40,000 HEALTHCARE DATA AND ANALYZING IT 2706 01:52:40,000 --> 01:52:41,920 USING THESE APPROACH AND THEY 2707 01:52:41,920 --> 01:52:43,600 REQUIRED DATA HARMONIZATION AND 2708 01:52:43,600 --> 01:52:46,080 IN SOME CASES IT'S TRIVIAL AND 2709 01:52:46,080 --> 01:52:47,760 HARD IN PRACTICE AND THEN 2710 01:52:47,760 --> 01:52:49,800 FINALLY OF COURSE THIS RELATES 2711 01:52:49,800 --> 01:52:52,560 DIRECTLY TO ONE OTHER MAJOR 2712 01:52:52,560 --> 01:52:54,680 FOCUS AREA OF NIDCR ADDRESSING 2713 01:52:54,680 --> 01:52:56,600 DISPARITIES AND INEQUALITIES IN 2714 01:52:56,600 --> 01:52:58,480 HEALTHCARE AND THIS RELATES BOTH 2715 01:52:58,480 --> 01:53:00,360 TO ACCESS TO HEALTHCARE FOR 2716 01:53:00,360 --> 01:53:02,960 PATIENTS BUT ALSO, TO 2717 01:53:02,960 --> 01:53:04,240 DISPARITIES AND INEQUALITIES 2718 01:53:04,240 --> 01:53:05,800 WHEN WE THINK ABOUT OUR 2719 01:53:05,800 --> 01:53:07,080 EDUCATIONAL APPROACH AND ABOUT 2720 01:53:07,080 --> 01:53:08,520 DIVERSITY OF OUR WORKFORCE AND 2721 01:53:08,520 --> 01:53:10,760 SO ON AND ALL OF THESE HAVE 2722 01:53:10,760 --> 01:53:12,560 EXCITING OPPORTUNITIES FOR DATA 2723 01:53:12,560 --> 01:53:16,560 SCIENCE AND DATA ENABLED 2724 01:53:16,560 --> 01:53:18,760 APPROACHES TO ADVANCE THIS. 2725 01:53:18,760 --> 01:53:20,400 WHEN WE THINK ABOUT DATA SCIENCE 2726 01:53:20,400 --> 01:53:23,600 IN THE CONTEXT OF NIH AND AS THE 2727 01:53:23,600 --> 01:53:25,600 BACKGROUND FOR OUR WORKING 2728 01:53:25,600 --> 01:53:27,920 GROUP, IT'S IMPORTANT TO POINT 2729 01:53:27,920 --> 01:53:30,760 OUT THAT NIH AS THE OVERARCHING 2730 01:53:30,760 --> 01:53:31,600 UMBRELLA OF COURSE HAS 2731 01:53:31,600 --> 01:53:33,040 RECOGNIZED IMPORTANCE OF DATA 2732 01:53:33,040 --> 01:53:43,560 FOR A LONG TIME SO, IT CAME OUT 2733 01:53:59,840 --> 01:54:02,040 IN 2018 AND IT HIGHLIGHTS HOW 2734 01:54:02,040 --> 01:54:03,800 BIO MEDICINE HAS ADVANCED INTO 2735 01:54:03,800 --> 01:54:07,800 AN ERA WHERE MANY TYPES OF DATA 2736 01:54:07,800 --> 01:54:08,680 FALL UNDER THE SPHERE OF BIG 2737 01:54:08,680 --> 01:54:10,520 DATA AND ALONG WITH IT COMES 2738 01:54:10,520 --> 01:54:11,600 ENORMOUS OPPORTUNITIES. 2739 01:54:11,600 --> 01:54:14,240 AND THIS HAS OF COURSE SPURRED A 2740 01:54:14,240 --> 01:54:17,160 VARIETY OF ACTIVITIES AT NIH IN 2741 01:54:17,160 --> 01:54:19,280 VARIOUS IOCs AND JUST ONE 2742 01:54:19,280 --> 01:54:20,800 EXAMPLE THAT I RANDOMLY PUT ON 2743 01:54:20,800 --> 01:54:23,200 THESE IS THE DIGITAL NIH 2744 01:54:23,200 --> 01:54:24,840 INITIATIVE AND INNOVATION 2745 01:54:24,840 --> 01:54:26,280 TECHNOLOGY COMMUTATION FOR THE 2746 01:54:26,280 --> 01:54:27,800 FUTURE OF NIH SO THIS IS A 2747 01:54:27,800 --> 01:54:31,640 REPORT PRESENTED IN 2022 AND 2748 01:54:31,640 --> 01:54:35,200 THAT HIGHLIGHTS VARIOUS AREAS OF 2749 01:54:35,200 --> 01:54:37,320 ACTIVITY OVERARCHING AT NIH. 2750 01:54:37,320 --> 01:54:40,760 WHEN WE THINK MORE SPECIFICALLY 2751 01:54:40,760 --> 01:54:41,920 ABOUT NIDCR, WE ALREADY SAW THE 2752 01:54:41,920 --> 01:54:46,880 COVER OF THIS EXCITING STRATEGIC 2753 01:54:46,880 --> 01:54:48,080 VISION AND NIDCR PUBLISHED AT 2754 01:54:48,080 --> 01:54:50,160 LAST YEAR AND IN THIS VISION, 2755 01:54:50,160 --> 01:54:55,240 DATA AND DATA SCIENCE PLAYS A 2756 01:54:55,240 --> 01:55:00,720 BIG ROLE SUCCESSFUL PACE-BASED 2757 01:55:00,720 --> 01:55:06,680 AS AN WAY HOW SIGNS AND WHEN YOU 2758 01:55:06,680 --> 01:55:08,720 LOOK AT THIS PLAN MORE CROWSLY, 2759 01:55:08,720 --> 01:55:10,000 DATA AND DATA SCIENCE IS ALL 2760 01:55:10,000 --> 01:55:12,120 OVER THE PLACE. 2761 01:55:12,120 --> 01:55:14,360 AND SO, WHEN YOU LOOK AT HOW THE 2762 01:55:14,360 --> 01:55:15,240 STRATEGIC PLAN IS ORGANIZED SO 2763 01:55:15,240 --> 01:55:17,760 THIS IS ESSENTIALLY WHAT Dr. 2764 01:55:17,760 --> 01:55:19,680 D'SOUZA SHOWED IN HER 2765 01:55:19,680 --> 01:55:20,640 INTRODUCTION JUST ORGANIZE 2766 01:55:20,640 --> 01:55:21,680 SLIGHTLY DIFFERENTLY THERE ARE 2767 01:55:21,680 --> 01:55:23,480 FIVE STRATEGIC PRIORITIES. 2768 01:55:23,480 --> 01:55:28,480 AND WHEN YOU LOOK MORE CLOSELY, 2769 01:55:28,480 --> 01:55:30,120 AT THE SPECIFIC GOALS TO EACH OF 2770 01:55:30,120 --> 01:55:31,440 THESE STRATEGIC PRIORITIES THAT 2771 01:55:31,440 --> 01:55:33,560 YOU FIND IN THIS STRATEGIC PLAN, 2772 01:55:33,560 --> 01:55:36,480 YOU WILL FIND MANY EXAMPLES 2773 01:55:36,480 --> 01:55:38,840 WHERE DATA IS REALLY AN INTEGRAL 2774 01:55:38,840 --> 01:55:41,800 COMPONENT AND CRITICALLY NEEDED 2775 01:55:41,800 --> 01:55:44,160 TO ACHIEVE THESE PRIORITIES. 2776 01:55:44,160 --> 01:55:45,800 SO, FOR EXAMPLE, THE FIRST ONE 2777 01:55:45,800 --> 01:55:48,840 IS INTEGRATE AND GENERAL HEALTH 2778 01:55:48,840 --> 01:55:51,360 AND WE HEARD ABOUT ALL OF US 2779 01:55:51,360 --> 01:55:54,520 DATA EARLIER TODAY RIGHT. 2780 01:55:54,520 --> 01:55:55,440 INTEGRATION OF THE CONDITIONS 2781 01:55:55,440 --> 01:55:57,440 WITH SYSTEMIC DISEASES ASKING 2782 01:55:57,440 --> 01:55:59,440 ALL OF US DATA AND THE 2783 01:55:59,440 --> 01:56:02,400 DEVELOPMENT OF UNIQUE AND SHARED 2784 01:56:02,400 --> 01:56:04,560 TAXONOMY FOR THE RESEARCH AND 2785 01:56:04,560 --> 01:56:06,080 VOCABULARY THAT HELP US PERFORM 2786 01:56:06,080 --> 01:56:10,040 THIS INTEGRATION. 2787 01:56:10,040 --> 01:56:13,200 PRECISION DENTAL MEDICINE. 2788 01:56:13,200 --> 01:56:15,000 HERE, OUR DATA ECOSYSTEM NEEDS 2789 01:56:15,000 --> 01:56:17,080 TO BE CREATED AND EXPANDED TO 2790 01:56:17,080 --> 01:56:20,880 IMPROVE HEALTH OUTCOMES IN 2791 01:56:20,880 --> 01:56:24,480 INDIVIDUALS POPULATION AND 2792 01:56:24,480 --> 01:56:26,120 REMOTE TELE DENT TREE REQUIRE 2793 01:56:26,120 --> 01:56:30,000 NEW APPROACHES FOR CAPTURING AND 2794 01:56:30,000 --> 01:56:30,800 HANDLING DATA. 2795 01:56:30,800 --> 01:56:32,240 THE THIRD STRATEGIC PRIORITY TO 2796 01:56:32,240 --> 01:56:35,480 TRANSLATE AND IMPLEMENT THIS 2797 01:56:35,480 --> 01:56:37,160 LINKS BACK TO WHAT I MENTIONED 2798 01:56:37,160 --> 01:56:39,880 EARLIER, ELECTRONIC HEALTH 2799 01:56:39,880 --> 01:56:40,400 RECORDS. 2800 01:56:40,400 --> 01:56:41,560 HOW DO WE COLLECT THIS DATA AND 2801 01:56:41,560 --> 01:56:45,040 MAKE IT AVAILABLE ACROSS SYSTEMS 2802 01:56:45,040 --> 01:56:47,560 AND HOW DO WE DEVELOP THESE AND 2803 01:56:47,560 --> 01:56:53,920 ACTION ON MWE SEE STANDARD TECHD 2804 01:56:53,920 --> 01:56:55,240 STRATEGIES PRIORITY FOUR IS THE 2805 01:56:55,240 --> 01:56:57,600 DIVERSE RESEARCH PIPELINE HERE 2806 01:56:57,600 --> 01:56:58,920 AND THIS OF COURSE NEEDS TO GO 2807 01:56:58,920 --> 01:57:01,200 HAND AND HAND WITH TRAINING AND 2808 01:57:01,200 --> 01:57:02,920 CAREER DEVELOPMENT OPPORTUNITIES 2809 01:57:02,920 --> 01:57:07,280 AND TO BID A RESEARCH PIPELINE 2810 01:57:07,280 --> 01:57:09,200 AROUND DATA SCIENCE AND THEN THE 2811 01:57:09,200 --> 01:57:14,000 FIFTH PARTY IS PARTNERING AND 2812 01:57:14,000 --> 01:57:14,360 COLLABORATION. 2813 01:57:14,360 --> 01:57:15,800 KNOWLEDGE SHARING OF 2814 01:57:15,800 --> 01:57:18,360 STAKEHOLDERS AND OUTREACH AS 2815 01:57:18,360 --> 01:57:19,480 ENORMOUS OPPORTUNITIES THROUGH 2816 01:57:19,480 --> 01:57:21,440 NEW DATA-DRIVEN APPROACHES. 2817 01:57:21,440 --> 01:57:25,120 WITH ALL OF THIS IN MIND, TO 2818 01:57:25,120 --> 01:57:27,400 SUMMARIZE WHAT OUR DATA SIGNS 2819 01:57:27,400 --> 01:57:28,560 STRATEGIES WORKING GROUP HAS 2820 01:57:28,560 --> 01:57:31,720 BEEN CHARGED WITH IS AS A 2821 01:57:31,720 --> 01:57:34,600 DRIVER, BUILDING ON THE NIDCR 2822 01:57:34,600 --> 01:57:36,400 STRATEGIC PLAN WHICH PUTS FOURTH 2823 01:57:36,400 --> 01:57:41,880 THE VISION FOR THE FUTURE AND 2824 01:57:41,880 --> 01:57:43,320 RECOGNIZING THE OPPORTUNITY THAT 2825 01:57:43,320 --> 01:57:45,800 LIES IN DATA SCIENCE FOR 2826 01:57:45,800 --> 01:57:47,800 PROVIDING A NEW BIOMEDICAL 2827 01:57:47,800 --> 01:57:49,320 INSIGHTS AND ADVANCING THE 2828 01:57:49,320 --> 01:57:50,880 DEVELOPMENT AND DELIVERY OF 2829 01:57:50,880 --> 01:57:51,960 HEALTH SOLUTIONS. 2830 01:57:51,960 --> 01:57:54,640 SO, THIS SPECIFIC ASK, FOR OUR 2831 01:57:54,640 --> 01:58:01,720 WORKING GROUP IS TO HELP 2832 01:58:01,720 --> 01:58:05,320 DEVELOPED A DATA SCIENCE 2833 01:58:05,320 --> 01:58:10,080 STRATEGY THAT POLITICIANS ALL OL 2834 01:58:10,080 --> 01:58:10,600 OF THIS. 2835 01:58:10,600 --> 01:58:11,920 THINKING ABOUT THE GAPS AND 2836 01:58:11,920 --> 01:58:12,880 OPPORTUNITIES OF INTEREST. 2837 01:58:12,880 --> 01:58:14,760 HERE SAY FIRST SET OF GAPS OF 2838 01:58:14,760 --> 01:58:15,600 OPPORTUNITIES AND IN THE 2839 01:58:15,600 --> 01:58:16,800 INTEREST OF TIME SO THAT WE HAVE 2840 01:58:16,800 --> 01:58:18,120 A LITTLE BIT OF TIME FOR 2841 01:58:18,120 --> 01:58:19,600 DISCUSSION LATER ON, I WILL NOT 2842 01:58:19,600 --> 01:58:21,560 TALK ABOUT ALL OF THESE IN 2843 01:58:21,560 --> 01:58:21,800 DETAIL. 2844 01:58:21,800 --> 01:58:25,800 YOU CAN FIND THE SLIDES IN YOUR 2845 01:58:25,800 --> 01:58:26,280 MATERIALS. 2846 01:58:26,280 --> 01:58:27,960 BROADLY SPEAKING, THESE FALL 2847 01:58:27,960 --> 01:58:32,200 INTO THE AREAS OF EVOLVING THE 2848 01:58:32,200 --> 01:58:35,040 ECOSYSTEM AND APPLYING DATA AND 2849 01:58:35,040 --> 01:58:38,800 DATA SCIENCE METHODS AND 2850 01:58:38,800 --> 01:58:39,720 EMPOWERING RESEARCH AND HEALTH 2851 01:58:39,720 --> 01:58:41,400 DISPARITIES AND UNI QUALITY AND 2852 01:58:41,400 --> 01:58:42,960 SOME OF THESE MAY LOOK FORWARD 2853 01:58:42,960 --> 01:58:45,120 AND I THINK DID D'SOUZA SHOWED 2854 01:58:45,120 --> 01:58:46,560 SOME OF THESE IN A PRESENTATION 2855 01:58:46,560 --> 01:58:50,080 THAT SHE GAVE AT THE MAY COUNCIL 2856 01:58:50,080 --> 01:58:50,320 MEETING. 2857 01:58:50,320 --> 01:58:51,800 AND WITHOUT GOING INTO TOO MUCH 2858 01:58:51,800 --> 01:58:55,400 DETAIL I WANT TO POINT OUT THIS 2859 01:58:55,400 --> 01:58:57,200 IS A LOT OF BULLETS HERE BUT 2860 01:58:57,200 --> 01:58:58,720 EVEN THAT MIGHT NOT CAPTURE 2861 01:58:58,720 --> 01:58:59,200 EVERYTHING. 2862 01:58:59,200 --> 01:59:01,440 SO ONE IMPORTANT TASK FORCE FOR 2863 01:59:01,440 --> 01:59:02,760 OUR DATA SCIENCE STRATEGY 2864 01:59:02,760 --> 01:59:04,160 WORKING GROUP IS TO LOOK AT 2865 01:59:04,160 --> 01:59:06,200 THESE CAREFULLY AND THINK ABOUT 2866 01:59:06,200 --> 01:59:08,080 WHICH OF THESE ARE THE HIGHEST 2867 01:59:08,080 --> 01:59:09,360 PRIORITIES AND THINK ABOUT 2868 01:59:09,360 --> 01:59:12,960 ADDITIONAL ONCE THAT SHOULD BE 2869 01:59:12,960 --> 01:59:13,320 RELEVANT. 2870 01:59:13,320 --> 01:59:17,240 SO, IN TERMS OF THE WAY OUR 2871 01:59:17,240 --> 01:59:20,760 WORKING GROUP IS INTENDED TO 2872 01:59:20,760 --> 01:59:21,680 OPERATE, THIS IS A BUILDING ON 2873 01:59:21,680 --> 01:59:24,520 THIS WORKING GROUP MODEL THAT 2874 01:59:24,520 --> 01:59:26,000 HAS BEEN QUITE SUCCESSFULLY USED 2875 01:59:26,000 --> 01:59:30,440 BUY ICs AND IN SOME CASES 2876 01:59:30,440 --> 01:59:33,880 SPECIFICALLY AROUND THE DATA 2877 01:59:33,880 --> 01:59:44,240 SCIENCE AND THAT COVER THE WHOLE 2878 01:59:44,240 --> 01:59:45,920 SPECTRUM OF SCIENTIFIC AND 2879 01:59:45,920 --> 01:59:47,840 CLINICAL EXPERTISE THAT WE WANT 2880 01:59:47,840 --> 01:59:50,760 TO COVER AND THAT IMPORTANTLY, 2881 01:59:50,760 --> 01:59:54,600 COVER THE TRANSLATIONAL SPECTRUM 2882 01:59:54,600 --> 01:59:56,120 THAT IS COVERED BY NIDCR. 2883 01:59:56,120 --> 01:59:57,800 WE WANT TO BE ABLE TO ADDRESS 2884 01:59:57,800 --> 02:00:01,200 DATA SCIENCE NEEDS FOR ALL FIVE 2885 02:00:01,200 --> 02:00:02,960 NIDCR STRATEGIC AREAS. 2886 02:00:02,960 --> 02:00:05,360 IN THE RECOMMENDATIONS THAT WE 2887 02:00:05,360 --> 02:00:07,040 WOULD PROVIDE TO COUNCIL, WE 2888 02:00:07,040 --> 02:00:10,600 WANT TO HAVE A MIX OF BOTH SHORT 2889 02:00:10,600 --> 02:00:13,000 TERM WHICH MEANS IMMEDIATELY 2890 02:00:13,000 --> 02:00:14,080 ACTIONABLE ITEMS AS WELL AS 2891 02:00:14,080 --> 02:00:16,440 LONG-TERM STRATEGIC 2892 02:00:16,440 --> 02:00:20,520 RECOMMENDATIONS THAT CAN BE 2893 02:00:20,520 --> 02:00:21,000 CONSIDERED. 2894 02:00:21,000 --> 02:00:22,520 AND I WILL SHOW YOU IN A MOMENT 2895 02:00:22,520 --> 02:00:26,360 AND WE KICKED OFF THE WORKING 2896 02:00:26,360 --> 02:00:36,880 GROUP AND IT WAS ABOUT A YEAR 2897 02:00:40,920 --> 02:00:42,240 FROM NOW AND WE WILL HOLD 2898 02:00:42,240 --> 02:00:43,720 RECOGNIZE WORKING GROUP MEETINGS 2899 02:00:43,720 --> 02:00:45,880 AND POSSIBLY DEDICATED WORKSHOP 2900 02:00:45,880 --> 02:00:49,080 WHICH WOULD BE IN-PERSON OR 2901 02:00:49,080 --> 02:00:52,760 VIRTUAL AND WE WILL GIVE REGULAR 2902 02:00:52,760 --> 02:00:53,720 UPDATES AT NIDCR COUNCIL AND BY 2903 02:00:53,720 --> 02:00:55,840 MYSELF OR THE CO-CHAIR MIGHT 2904 02:00:55,840 --> 02:00:58,960 GIVE THEM AND THEN THE MAIN 2905 02:00:58,960 --> 02:01:01,360 DELIVERABLE WILL BE A FINAL 2906 02:01:01,360 --> 02:01:03,040 REPORT TO COUNCIL TYPICALLY 2907 02:01:03,040 --> 02:01:04,600 GIVEN IN A FORM OF A 2908 02:01:04,600 --> 02:01:06,160 PRESENTATION ALONG WITH A 2909 02:01:06,160 --> 02:01:08,160 DOCUMENT AND THAT SUMMARIZES 2910 02:01:08,160 --> 02:01:10,040 WHAT WE'RE RECOMMENDING AND 2911 02:01:10,040 --> 02:01:16,680 PRIORITIZES THE VARIOUS ITEMS 2912 02:01:16,680 --> 02:01:19,080 AND WE MAY FOLLOW IT UP AND SOME 2913 02:01:19,080 --> 02:01:20,000 WORKING GROUPS HAVE DONE WHICH 2914 02:01:20,000 --> 02:01:21,480 CAN HELP TO INCREASE THE 2915 02:01:21,480 --> 02:01:23,000 VISIBILITY OF THIS 2916 02:01:23,000 --> 02:01:25,120 RECOMMENDATIONS AND FOR THE 2917 02:01:25,120 --> 02:01:26,120 LARGER COMMUNITY. 2918 02:01:26,120 --> 02:01:27,680 SO WHERE DO WE STAND? 2919 02:01:27,680 --> 02:01:30,800 OF THE PAST MONTH WE'VE BEEN 2920 02:01:30,800 --> 02:01:32,960 WORKING HARD ON THIS SO THOSE 2921 02:01:32,960 --> 02:01:36,800 WORKING CLOSELY TOGETHER WITH 2922 02:01:36,800 --> 02:01:37,480 NIDCR STAFF WE HAVE A CHAIR 2923 02:01:37,480 --> 02:01:43,280 WHICH IS ME AND A CO-CHAIR AND 2924 02:01:43,280 --> 02:01:47,200 WE HAVE OF THE LAST MONTH OR TWO 2925 02:01:47,200 --> 02:01:50,400 AND WORKED WITH TO COLLABORATE 2926 02:01:50,400 --> 02:01:51,880 IDENTIFY CANDIDATES WHO MIGHT 2927 02:01:51,880 --> 02:01:54,520 SERVE ON THIS AND 12 MEMBERS 2928 02:01:54,520 --> 02:01:56,720 WERE SELECTED AND INVITED BY 2929 02:01:56,720 --> 02:01:58,640 Dr. D'SOUZA AND THEY HAVE NOW 2930 02:01:58,640 --> 02:02:06,400 BEEN APPOINTED SO, I'M EXCITED 2931 02:02:06,400 --> 02:02:07,720 THE MEMBERS OF OUR WORKING GROUP 2932 02:02:07,720 --> 02:02:09,480 SO WE HAVE THE 12 MEMBERS THAT 2933 02:02:09,480 --> 02:02:11,240 MAKE UP THE WORKING GROUP AND WE 2934 02:02:11,240 --> 02:02:14,200 HAVE THREE STAFF FROM NIDCR WHO 2935 02:02:14,200 --> 02:02:15,960 PARTICIPATED IN THESE MEETINGS, 2936 02:02:15,960 --> 02:02:20,640 LYNN AND JOHN AND LIEU WANG WHO 2937 02:02:20,640 --> 02:02:22,200 SUPPORT US IN DRIVING 24 WORKING 2938 02:02:22,200 --> 02:02:22,440 GROUP. 2939 02:02:22,440 --> 02:02:24,240 WHEN YOU LOCK AT OUR 12 MEMBERS, 2940 02:02:24,240 --> 02:02:26,960 YOU CAN SEE THAT THERE ARE VERY 2941 02:02:26,960 --> 02:02:28,480 DIVERSE BOTH IN TERMS OF THE 2942 02:02:28,480 --> 02:02:31,240 PEOPLE WHO ARE REPRESENTED BUT 2943 02:02:31,240 --> 02:02:33,720 MORE IMPORTANTLY IN THE 2944 02:02:33,720 --> 02:02:35,120 EXPERTISE THEY CAN CARRY. 2945 02:02:35,120 --> 02:02:36,760 CAN YOU SEE WE COVER A WIDE 2946 02:02:36,760 --> 02:02:40,080 RANGE OF SCIENTIFIC AND CLINICAL 2947 02:02:40,080 --> 02:02:41,240 DISCIPLINES GOING FROM THINGS 2948 02:02:41,240 --> 02:02:45,200 LIKE GENOMICS, MYSELF, ONCOLOGY, 2949 02:02:45,200 --> 02:02:46,840 MACHINE LEARNING SO BASIC 2950 02:02:46,840 --> 02:02:48,520 COMPUTATIONAL SCIENCE AND ALL 2951 02:02:48,520 --> 02:02:50,320 THE WAY THINGS SUCH AS BEHAVIOR 2952 02:02:50,320 --> 02:02:53,560 AND THEN IT GOES INTO CLINICAL 2953 02:02:53,560 --> 02:02:55,920 AND COMMUNITY RELATED ISSUES AND 2954 02:02:55,920 --> 02:02:57,480 HEALTH INFORMATION TECHNOLOGY 2955 02:02:57,480 --> 02:02:59,720 AND HEALTH EQUITY. 2956 02:02:59,720 --> 02:03:01,280 SO SOMETHING THAT WAS ALSO 2957 02:03:01,280 --> 02:03:03,280 IMPORTANT FOR US TO COVER THE 2958 02:03:03,280 --> 02:03:06,520 ENTIRE TRANSLATIONAL SPECTRUM. 2959 02:03:06,520 --> 02:03:11,360 THIS IS TYPICALLY CATEGORIZED 2960 02:03:11,360 --> 02:03:12,720 THAT COVER FROM BASIC RESEARCH 2961 02:03:12,720 --> 02:03:15,440 TO TRANSLATION TO HUMANS AND 2962 02:03:15,440 --> 02:03:17,560 PATIENTS FOR CLINICAL STUDIES 2963 02:03:17,560 --> 02:03:18,920 AND TRANSLATION AND LIMITATIONS 2964 02:03:18,920 --> 02:03:20,440 IN CLINICAL PRACTICE AND THEN 2965 02:03:20,440 --> 02:03:28,080 ALL THE WAY INTO TRANSLATION TO 2966 02:03:28,080 --> 02:03:28,400 COMMUNITIES. 2967 02:03:28,400 --> 02:03:29,720 AS WE SELECTED THE PARTICIPANTS 2968 02:03:29,720 --> 02:03:31,520 IN THIS WORKING GROUP, WE AIMED 2969 02:03:31,520 --> 02:03:33,160 TO COVER THIS SPECTRUM AND YOU 2970 02:03:33,160 --> 02:03:35,520 SEE HERE BASED ON 2971 02:03:35,520 --> 02:03:36,840 SELF-IDENTIFIED AREAS OF 2972 02:03:36,840 --> 02:03:39,760 COVERAGE THAT WE NICELY COVERED 2973 02:03:39,760 --> 02:03:41,400 THE SPECTRUM AND THIS HOPEFULLY 2974 02:03:41,400 --> 02:03:43,560 WOULD ENABLE US TO COME UP WITH 2975 02:03:43,560 --> 02:03:46,560 A SET OF RECOMMENDATIONS THAT 2976 02:03:46,560 --> 02:03:48,400 CARRIES ALL AREAS OF SCIENTIFIC 2977 02:03:48,400 --> 02:03:51,560 AND CLINICAL EXPERTISE BY ALSO 2978 02:03:51,560 --> 02:03:54,400 COVERING ALL ASPECTS OF 2979 02:03:54,400 --> 02:03:57,120 DEVELOPING BASIC RESEARCH INSIDE 2980 02:03:57,120 --> 02:04:03,560 AND TAKE THEM ALL THE WAY INTO 2981 02:04:03,560 --> 02:04:03,960 PRACTICE. 2982 02:04:03,960 --> 02:04:06,400 WE JUST HAD OUR KICKOFF MEETING 2983 02:04:06,400 --> 02:04:07,560 SEPTEMBER 1st AND TODAY'S MY 2984 02:04:07,560 --> 02:04:10,760 FIRST OFFICIAL REPORT TO 2985 02:04:10,760 --> 02:04:11,120 COUNCIL. 2986 02:04:11,120 --> 02:04:16,360 THE NEXT STEPS FOR US WILL BE TO 2987 02:04:16,360 --> 02:04:17,680 ESTABLISH REMEMBER MEETINGS FOR 2988 02:04:17,680 --> 02:04:18,600 THE SCOPE, BOUNDARIES AND 2989 02:04:18,600 --> 02:04:20,920 APPROACH AND DELIVERABLES AND A 2990 02:04:20,920 --> 02:04:22,360 MAJOR EFFORT HERE WILL BE TO 2991 02:04:22,360 --> 02:04:25,200 DEFINE THE SCOPE AND BOUNDARIES 2992 02:04:25,200 --> 02:04:26,800 BECAUSE AS YOU SAW, THIS IS 2993 02:04:26,800 --> 02:04:33,200 POTENTIALLY AN ENORMOUS PROGRESS 2994 02:04:33,200 --> 02:04:34,760 AND WE WANT MEANINGFUL 2995 02:04:34,760 --> 02:04:37,480 RECOMMENDATIONS IN THE TIME 2996 02:04:37,480 --> 02:04:38,800 RANGE OF A YEAR SO WE HAVE TO 2997 02:04:38,800 --> 02:04:40,480 DECIDE WHAT WE WANT TO FOCUS ON 2998 02:04:40,480 --> 02:04:41,640 AND HOW WE DO THIS. 2999 02:04:41,640 --> 02:04:43,440 WE WILL KEEP YOU POSTED THROUGH 3000 02:04:43,440 --> 02:04:44,320 REGULAR UPDATES AND IN THE 3001 02:04:44,320 --> 02:04:46,720 FUTURE OF THE COUNCIL MEETINGS 3002 02:04:46,720 --> 02:04:49,640 AND OF COURSE WE WILL FILL THE 3003 02:04:49,640 --> 02:04:50,600 NIDCR PARTICIPANTS IN OUR 3004 02:04:50,600 --> 02:04:52,120 WORKING GROUP AND MAKE SURE IS 3005 02:04:52,120 --> 02:04:54,560 THAT WHATEVER WE DO IS CLOSELY 3006 02:04:54,560 --> 02:04:59,560 ALIGNED WITH THE EXPECTATIONS OF 3007 02:04:59,560 --> 02:05:01,000 NIDCR P THAT CONCLUDES MY REPORT 3008 02:05:01,000 --> 02:05:03,880 AND I HOPE I LEFT A MINUTE OR 3009 02:05:03,880 --> 02:05:07,960 TWO FOR QUESTIONS. 3010 02:05:07,960 --> 02:05:11,480 >> Lynn M. King: THANK YOU. 3011 02:05:11,480 --> 02:05:11,960 ANY QUESTIONS? 3012 02:05:11,960 --> 02:05:14,560 ABOUT THE COUNCIL WORKING GROUP. 3013 02:05:14,560 --> 02:05:17,080 >> A BIG VIRTUAL HUG TO YOU. 3014 02:05:17,080 --> 02:05:19,560 THIS IS EXACTLY THE DIRECTION WE 3015 02:05:19,560 --> 02:05:24,440 HAD ENVISIONED AND I WONDERED IF 3016 02:05:24,440 --> 02:05:26,360 YOU GROUP WOULD CONSIDER THE 3017 02:05:26,360 --> 02:05:27,080 TRAINING OPPORTUNITIES. 3018 02:05:27,080 --> 02:05:28,960 WE'RE FINDING THAT DENTISTS OR 3019 02:05:28,960 --> 02:05:34,000 ORAL HEALTH RESEARCHERS ARE 3020 02:05:34,000 --> 02:05:35,280 NEEDED FOR THE DATA SCIENCE 3021 02:05:35,280 --> 02:05:39,280 FIELD SO THIS NEED FOR TRAINING 3022 02:05:39,280 --> 02:05:49,800 AND THE WOULD YOU DO RESOURCE 3023 02:06:01,800 --> 02:06:03,640 AND WHERE GAPS LIE, RIGHT? 3024 02:06:03,640 --> 02:06:06,840 >> YES, SO TO YOUR FIRST POINT, 3025 02:06:06,840 --> 02:06:08,120 YES, TRAINING OPPORTUNITIES THAT 3026 02:06:08,120 --> 02:06:10,640 TALK BRIEFLY ABOUT HOW THIS GOES 3027 02:06:10,640 --> 02:06:15,320 HAND AND HAND WITH BUILDING A 3028 02:06:15,320 --> 02:06:19,960 FUTURE WORKFORCE THAT COVERS 3029 02:06:19,960 --> 02:06:25,560 THIS AREA OF EXPERTISE AND 3030 02:06:25,560 --> 02:06:28,120 SPECIFICALLY, MAKES IT INTER 3031 02:06:28,120 --> 02:06:29,320 ELECT WITH THE NEEDS SO THAT 3032 02:06:29,320 --> 02:06:31,040 WOULD BE AN IMPORTANT ASPECT OF 3033 02:06:31,040 --> 02:06:32,680 IT. 3034 02:06:32,680 --> 02:06:35,480 IN TERMS OF LEVERAGING EXISTING 3035 02:06:35,480 --> 02:06:40,640 SYSTEMS, I THINK FIRST IMPORTANT 3036 02:06:40,640 --> 02:06:43,360 TASK WILL BE THE FACT FINDING 3037 02:06:43,360 --> 02:06:45,360 STAGE OF THIS WORKING GROUP TO 3038 02:06:45,360 --> 02:06:55,720 REALLY GET A SENSE OF. 3039 02:07:29,320 --> 02:07:31,520 >> ONE QUICK QUESTION. 3040 02:07:31,520 --> 02:07:34,400 THANK YOU FOR A TERRIFIC 3041 02:07:34,400 --> 02:07:36,080 PRESENTATION AND PUTTING ALL 3042 02:07:36,080 --> 02:07:39,920 THIS INFORMATION AND THE WORKING 3043 02:07:39,920 --> 02:07:50,200 GROUP TOGETHER. 3044 02:08:06,320 --> 02:08:08,680 >> THANK YOU FOR THAT 3045 02:08:08,680 --> 02:08:08,960 SUGGESTION. 3046 02:08:08,960 --> 02:08:18,080 >> WE DO HAVE THAT. 3047 02:08:18,080 --> 02:08:19,760 I'VE ALSO BECOME AWARE OF THESE 3048 02:08:19,760 --> 02:08:24,800 DENTAL INFORM ATTICS PROGRAMS ON 3049 02:08:24,800 --> 02:08:27,040 GOING SO IT'S TRAINING OUR NEXT 3050 02:08:27,040 --> 02:08:28,440 GENERATION OF PEOPLE WHO ARE 3051 02:08:28,440 --> 02:08:30,680 LIKELY CARRYING OUT THESE DATA 3052 02:08:30,680 --> 02:08:33,160 SCIENCES SO I'M JUST WONDERING 3053 02:08:33,160 --> 02:08:37,120 ABOUT INCLUSION OF THAT AS A 3054 02:08:37,120 --> 02:08:38,880 IMPORTANT STAKEHOLDER AS WE MOVE 3055 02:08:38,880 --> 02:08:43,200 FORWARD WITH THIS EFFORT, AXEL. 3056 02:08:43,200 --> 02:08:48,400 >> SO I THINK THIS WILL GO HAND 3057 02:08:48,400 --> 02:08:58,600 AND HAND. 3058 02:09:05,080 --> 02:09:06,680 AS WE MAKE RECOMMENDATIONS 3059 02:09:06,680 --> 02:09:08,720 VEMMING THE FUTURE WORKFORCE, 3060 02:09:08,720 --> 02:09:10,200 THIS SHOULD BE AN INTEGRAL PART 3061 02:09:10,200 --> 02:09:12,680 OF IT BECAUSE BY MAKING 3062 02:09:12,680 --> 02:09:16,080 RECOMMENDATIONS OF HOW THIS MAY 3063 02:09:16,080 --> 02:09:18,360 BE BUILT AND THIS CAN AT THE 3064 02:09:18,360 --> 02:09:20,200 SAME TIME, TAKE INTO 3065 02:09:20,200 --> 02:09:21,240 CONSIDERATION IN PARTICULAR 3066 02:09:21,240 --> 02:09:22,200 RECOMMENDATIONS THAT WE MAY GET 3067 02:09:22,200 --> 02:09:23,640 EVEN FROM THE OTHER WORKING 3068 02:09:23,640 --> 02:09:25,800 GROUP THAT FOCUSES MORE 3069 02:09:25,800 --> 02:09:28,320 SPECIFICALLY ON THESE ASPECTS. 3070 02:09:28,320 --> 02:09:28,840 >> YEAH. 3071 02:09:28,840 --> 02:09:29,920 >> IF THAT MAKES SENSE. 3072 02:09:29,920 --> 02:09:33,240 >> YEAH. 3073 02:09:33,240 --> 02:09:36,080 >> OK. 3074 02:09:36,080 --> 02:09:42,320 AT THIS POINT, WE HAVE A BREAK 3075 02:09:42,320 --> 02:09:44,520 SCHEDULED UNTIL 12:35 AND THAT 3076 02:09:44,520 --> 02:09:47,200 IS SHORTED BY THREE MINUTES IS 3077 02:09:47,200 --> 02:09:50,040 THAT OK BY EVERYONE TO RECONVENE 3078 02:09:50,040 --> 02:09:54,200 BY 12:35? 3079 02:09:54,200 --> 02:09:57,160 >> THANK YOU, VERY MUCH. 3080 02:09:57,160 --> 02:10:00,400 IT'S SETTING US UP FOR THE 3081 02:10:00,400 --> 02:10:00,640 FUTURE. 3082 02:10:00,640 --> 02:10:01,720 >> THANK YOU. 3083 02:10:01,720 --> 02:10:04,840 AND WE'LL SEE EVERYONE BACK. 3084 02:10:04,840 --> 02:10:07,920 >> MAY I INTERJECT. 3085 02:10:07,920 --> 02:10:11,240 THERE'S A TRADITION WAY TO DO 3086 02:10:11,240 --> 02:10:12,680 WORKING GROUPS BUT IF THERE'S A 3087 02:10:12,680 --> 02:10:14,560 WEBINAR IN THE MIDDLE OF THE 3088 02:10:14,560 --> 02:10:17,720 YEAR WHILE AXEL IS GATHERED HIS 3089 02:10:17,720 --> 02:10:20,160 DUE DILIGENCE TO JUST MAKE SURE 3090 02:10:20,160 --> 02:10:21,840 THE CONNECTIONS TO ADA AND THE 3091 02:10:21,840 --> 02:10:25,160 OTHER ORGANIZATIONS ARE MAINTAIN 3092 02:10:25,160 --> 02:10:27,040 AND TO OUR CONSTITUENTS IN 3093 02:10:27,040 --> 02:10:29,520 GENERAL AND IT COULD BE, I GUESS 3094 02:10:29,520 --> 02:10:32,000 THERE'S FLEXIBILITY TO DO THAT 3095 02:10:32,000 --> 02:10:32,920 STUFF, RIGHT. 3096 02:10:32,920 --> 02:10:33,240 COMMUNICATION. 3097 02:10:33,240 --> 02:10:34,680 >> ABSOLUTELY. 3098 02:10:34,680 --> 02:10:36,640 INVOLVING THE PUBLIC IN THE 3099 02:10:36,640 --> 02:10:38,280 CONVERSATION IS A KEY COMPONENT 3100 02:10:38,280 --> 02:10:48,600 OF THE WORKING GROUP. 3101 02:10:48,600 --> 02:10:51,520 >> WITH THAT COMES A WEBSITE 3102 02:10:51,520 --> 02:10:52,920 WITH PEOPLE COMING HERE AND 3103 02:10:52,920 --> 02:10:54,360 GIVING SEMINARS AND WORKSHOPS 3104 02:10:54,360 --> 02:10:58,680 AND THINGS SO THAT WE CAN BUILD 3105 02:10:58,680 --> 02:10:59,080 THE INTEREST. 3106 02:10:59,080 --> 02:10:59,840 >> YES. 3107 02:10:59,840 --> 02:11:03,160 WE SHOULD HAVE A SITE FOR A 3108 02:11:03,160 --> 02:11:08,560 WORKING GROUP POSTED ON YO OUR 3109 02:11:08,560 --> 02:11:10,120 PUBLIC FACING PART OF YOU ARE 3110 02:11:10,120 --> 02:11:13,560 INTERNET WEBSITE AND WE NEED TO 3111 02:11:13,560 --> 02:11:17,160 DEVELOP AND WE CAN POST ALL THAT 3112 02:11:17,160 --> 02:11:18,240 ADDITIONAL INFORMATION AND 3113 02:11:18,240 --> 02:11:19,160 MATERIALS THAT WOULD BE OF OF 3114 02:11:19,160 --> 02:11:29,320 INTEREST. 3115 02:11:40,200 --> 02:11:43,640 >> OUR NEXT 3116 02:11:43,640 --> 02:11:45,920 SPEAKER WILL BE Dr. DANA 3117 02:11:45,920 --> 02:11:47,240 GRAVES AND HE WILL PROVIDE AN 3118 02:11:47,240 --> 02:11:48,080 ORAL HEALTH RESEARCH WORKING 3119 02:11:48,080 --> 02:11:49,120 GROUP WHICH IS THE SECOND 3120 02:11:49,120 --> 02:11:53,080 WORKING GROUP THAT HAS BEEN 3121 02:11:53,080 --> 02:11:55,560 STOOD UP BY NIDCR. 3122 02:11:55,560 --> 02:11:57,760 IF WE CAN Dr. Dr. GRAVES, IF 3123 02:11:57,760 --> 02:12:03,200 YOU ARE GOING TO PRESENT YOUR 3124 02:12:03,200 --> 02:12:03,400 SLIDES. 3125 02:12:03,400 --> 02:12:08,920 >> JUST GIVE ME ONE SECOND. 3126 02:12:08,920 --> 02:12:11,760 CAN YOU SEE MY SCREEN? 3127 02:12:11,760 --> 02:12:12,480 >> Lynn M. King: YES, IT LOOKS 3128 02:12:12,480 --> 02:12:12,680 GREAT. 3129 02:12:12,680 --> 02:12:14,560 >> THANK YOU. 3130 02:12:14,560 --> 02:12:17,040 SO IT'S A REAL PLEASURE TO HAVE 3131 02:12:17,040 --> 02:12:18,560 THIS OPPORTUNITY TO SHARE THIS 3132 02:12:18,560 --> 02:12:23,240 IMPORTANT WORKING GROUP AND WHEN 3133 02:12:23,240 --> 02:12:24,520 RENA FIRST TOLD ME SHE'S GOING 3134 02:12:24,520 --> 02:12:26,560 TO GIVE ME A CHARGE, I THOUGHT, 3135 02:12:26,560 --> 02:12:27,920 WELL I DON'T HAVE AN ELECTRIC 3136 02:12:27,920 --> 02:12:30,240 CAR WITH A BATTERY PROBLEM BUT 3137 02:12:30,240 --> 02:12:31,960 IT TURNED OUT WHAT SHE WAS 3138 02:12:31,960 --> 02:12:34,360 REFERRING TO AS TASK OF 3139 02:12:34,360 --> 02:12:42,640 DEVELOPING AND RECOMMENDING AN 3140 02:12:42,640 --> 02:12:43,400 EVIDENCE BASED APPROACH TO 3141 02:12:43,400 --> 02:12:44,160 RETAIN WORKERS. 3142 02:12:44,160 --> 02:12:47,080 THIS IS IMPORTANT IN DENTAL, 3143 02:12:47,080 --> 02:12:49,720 CORRAL AND CRANIOFACIAL RESEARCH 3144 02:12:49,720 --> 02:12:51,880 FOR BECAUSE OF DWINDLING 3145 02:12:51,880 --> 02:12:52,120 NUMBERS. 3146 02:12:52,120 --> 02:12:55,560 WE HAVE FORMED AN WORKING GROUP 3147 02:12:55,560 --> 02:13:01,960 WITH HELP FROM LYNN KING AND 3148 02:13:01,960 --> 02:13:03,360 ANISA BROWN WHOA ARE MEMBERS AND 3149 02:13:03,360 --> 02:13:06,000 THIS IS IS A VERY ENERGETIC, 3150 02:13:06,000 --> 02:13:08,480 DIVERSE AND CHATTY GROUP AND WHO 3151 02:13:08,480 --> 02:13:09,680 ENJOY TALKING ABOUT TRAINING AND 3152 02:13:09,680 --> 02:13:14,840 ARE PASSIONATE ABOUT IT. 3153 02:13:14,840 --> 02:13:19,720 AS BACKGROUND, THERE'S A 3154 02:13:19,720 --> 02:13:25,680 SIGNIFICANT ISSUE WITH THE 3155 02:13:25,680 --> 02:13:26,760 WORKFORCE WHICH HAS DECLINED 3156 02:13:26,760 --> 02:13:28,120 OVER TIME IN DECADES. 3157 02:13:28,120 --> 02:13:30,840 THE DIVERSITY OF THIS WORKFORCE 3158 02:13:30,840 --> 02:13:32,840 IS LOW AND AN ISSUE THAT IS 3159 02:13:32,840 --> 02:13:34,360 IMPORTANT AND COMES UP 3160 02:13:34,360 --> 02:13:37,360 FREQUENTLY IS THE CAREER 3161 02:13:37,360 --> 02:13:38,880 PROGRESSION OF WOMEN DECLINING 3162 02:13:38,880 --> 02:13:41,120 COMPARED TO MEN. 3163 02:13:41,120 --> 02:13:43,120 FOR A DENTIST SCIENTIST, THERE 3164 02:13:43,120 --> 02:13:47,000 ARE ALSO SPECIFIC ISSUES THAT 3165 02:13:47,000 --> 02:13:48,640 INCLUDE THE HIGH LOAD OF 3166 02:13:48,640 --> 02:13:50,760 EDUCATIONAL DEBT, CHALLENGES AND 3167 02:13:50,760 --> 02:13:54,880 BALANCING CLINICAL AND RESEARCH 3168 02:13:54,880 --> 02:13:56,080 TRAINING, DIFFICULTY IN 3169 02:13:56,080 --> 02:13:58,360 BALANCING CAREER OBJECTIVES, AND 3170 02:13:58,360 --> 02:14:04,080 LACK OF SUPPORT AND INCENTIVES 3171 02:14:04,080 --> 02:14:05,800 WHICH IS OFTEN FELT BY THE 3172 02:14:05,800 --> 02:14:07,840 TRAINEES GOING INTO A CAREER 3173 02:14:07,840 --> 02:14:14,480 WITH LONG HORSE HOURS AND LOW PH 3174 02:14:14,480 --> 02:14:15,160 THAT IS NOT TRUE. 3175 02:14:15,160 --> 02:14:17,320 THERE'S A NEED TO INVIGORATE 3176 02:14:17,320 --> 02:14:19,640 TRAINING TO ENHANCE EMERGING 3177 02:14:19,640 --> 02:14:25,640 SCIENCES AND TECHNOLOGIES AND TO 3178 02:14:25,640 --> 02:14:28,560 ENHANCE INCREASE SCIENCE OF 3179 02:14:28,560 --> 02:14:31,200 WHICH AND ALSO TO INCREASE 3180 02:14:31,200 --> 02:14:32,520 TRANSLATIONAL RESEARCH WHICH IS 3181 02:14:32,520 --> 02:14:40,560 AN IMPORTANT OBJECTIVE FOR NIDCR 3182 02:14:40,560 --> 02:14:41,960 AND FOR NCCIH. 3183 02:14:41,960 --> 02:14:44,600 THE COMMITTEE HAS MET TWICE. 3184 02:14:44,600 --> 02:14:45,760 WE CAN FIND QUESTIONS THAT WERE 3185 02:14:45,760 --> 02:14:48,400 GOING TO BE IMPORTANT TO 3186 02:14:48,400 --> 02:14:48,600 ADDRESS. 3187 02:14:48,600 --> 02:14:52,160 AND SOME OF THESE QUESTIONS ARE, 3188 02:14:52,160 --> 02:14:53,600 WHAT DOES AN EXCELLENT PROGRAM 3189 02:14:53,600 --> 02:14:54,200 LOOK LIKE? 3190 02:14:54,200 --> 02:14:56,760 WHAT ARE THE OUTCOMES OF AN 3191 02:14:56,760 --> 02:14:57,600 OUTSTANDING PROGRAM? 3192 02:14:57,600 --> 02:14:59,880 WHAT TYPES OF TRAINING PROGRAMS 3193 02:14:59,880 --> 02:15:00,440 ARE EFFECTIVE? 3194 02:15:00,440 --> 02:15:02,560 AND WHAT CAN WE LEARN FROM 3195 02:15:02,560 --> 02:15:06,800 TRAINING PROGRAMS THAT ALREADY 3196 02:15:06,800 --> 02:15:07,640 EXIT AT NIDCR AND OTHER 3197 02:15:07,640 --> 02:15:11,120 INSTITUTES AND AGENCIES. 3198 02:15:11,120 --> 02:15:16,960 ADDITIONAL QUESTIONS ARE, WHAT 3199 02:15:16,960 --> 02:15:23,360 METHODS ARE USED FOR PROGRAMS 3200 02:15:23,360 --> 02:15:33,680 AND IT WOULD INCLUDE 3201 02:15:34,080 --> 02:15:34,960 INTERACTIONS WITH PHARMA WHICH 3202 02:15:34,960 --> 02:15:37,560 IS IMPORTANT AS WELL AS A 3203 02:15:37,560 --> 02:15:41,520 PARTNERSHIP WITH OTHER 3204 02:15:41,520 --> 02:15:42,200 STAKEHOLDERS. 3205 02:15:42,200 --> 02:15:45,000 THE OTHER ISSUE THAT THIS 3206 02:15:45,000 --> 02:15:47,280 WORKING GROUP IS GOING TO TACKLE 3207 02:15:47,280 --> 02:15:50,840 IS THE ISSUE OF DIVERSITY AND AN 3208 02:15:50,840 --> 02:15:54,480 IMPORTANT COMPONENT OF ENHANCING 3209 02:15:54,480 --> 02:15:55,920 DIVERSITY IS WHEN SHOULD THE 3210 02:15:55,920 --> 02:16:01,840 LEVEL OF ENGAGEMENT BEGIN. 3211 02:16:01,840 --> 02:16:02,840 SO THAT'S AN IMPORTANT QUESTION 3212 02:16:02,840 --> 02:16:03,840 THAT WAS BROUGHT UP. 3213 02:16:03,840 --> 02:16:06,280 SO WE HAVE OUTLINED FAIRLY 3214 02:16:06,280 --> 02:16:08,520 AGGRESSIVE AGENDA. 3215 02:16:08,520 --> 02:16:11,720 THE INITIAL MEETINGS FROM NOW 3216 02:16:11,720 --> 02:16:15,280 UNTIL DECEMBER WILL BE BASED ON 3217 02:16:15,280 --> 02:16:16,360 ACQUIRING INFORMATION, MEETING 3218 02:16:16,360 --> 02:16:18,680 WITH DIFFERENT STAKEHOLDER 3219 02:16:18,680 --> 02:16:22,360 GROUPS AND GETTING INFORMATION 3220 02:16:22,360 --> 02:16:23,560 FROM NIDCR AND OTHER TRAINING 3221 02:16:23,560 --> 02:16:27,000 PROGRAMS AT NIH. 3222 02:16:27,000 --> 02:16:28,920 THAT WILL BE FOLLOWED FROM 3223 02:16:28,920 --> 02:16:32,280 JANUARY TO MARCH WITH ADDRESSING 3224 02:16:32,280 --> 02:16:35,040 ACTION ITEMS AND THIS IS AN 3225 02:16:35,040 --> 02:16:36,680 EVALUATION PERIOD SO WE'LL TAKE 3226 02:16:36,680 --> 02:16:38,200 THE INFORMATION THAT WE RECEIVED 3227 02:16:38,200 --> 02:16:41,800 AND EVALUATE IT AND THEN FROM 3228 02:16:41,800 --> 02:16:44,400 APRIL TO JULY, WE WILL WORK ON 3229 02:16:44,400 --> 02:16:49,200 DEVELOPING RECOMMENDATIONS TO 3230 02:16:49,200 --> 02:16:53,360 THE COUNCIL. 3231 02:16:53,360 --> 02:16:54,960 SO THE INFORMATION SESSION HAVE 3232 02:16:54,960 --> 02:16:58,160 BEEN DEVELOPED AND OUTLINED. 3233 02:16:58,160 --> 02:17:01,600 THEY WILL INCLUDE A CURRENT 3234 02:17:01,600 --> 02:17:02,520 INFORMATION ON NIDCR RESEARCH 3235 02:17:02,520 --> 02:17:03,720 TRAINING PROGRAMS AND WE'VE 3236 02:17:03,720 --> 02:17:07,040 ALREADY HAD THIS INFORMATION 3237 02:17:07,040 --> 02:17:16,000 SESSION AND AN KNE ANISA BROWN N 3238 02:17:16,000 --> 02:17:16,720 EXCELLENT JOB. 3239 02:17:16,720 --> 02:17:23,560 WET ASSESS RESEARCH TRAINING 3240 02:17:23,560 --> 02:17:24,920 SESSIONS AND WE WILL LISTEN AND 3241 02:17:24,920 --> 02:17:26,400 THEY WILL BE WITH CURRENT AND 3242 02:17:26,400 --> 02:17:28,400 PREVIOUS TRAINEES AS WELL AS KEY 3243 02:17:28,400 --> 02:17:30,360 STAKEHOLDERS AND SOME OF THEE 3244 02:17:30,360 --> 02:17:32,600 SKI STAKE SHOULDERS GROUPS 3245 02:17:32,600 --> 02:17:34,480 INCLUDES PROGRAM DIRECTORS, 3246 02:17:34,480 --> 02:17:38,440 UNIVERSITY TRAINING PROGRAMS, 3247 02:17:38,440 --> 02:17:42,600 THEY WILL INCLUDE CHAIRS AND 3248 02:17:42,600 --> 02:17:43,840 DEANS THAT REPRESENT KEY 3249 02:17:43,840 --> 02:17:47,960 DECISION MAKERS AND HIRING 3250 02:17:47,960 --> 02:17:52,000 TRAINEES AND ALSO INDIVIDUALS IN 3251 02:17:52,000 --> 02:17:53,400 INDUSTRY CONSIDERING THEIR 3252 02:17:53,400 --> 02:17:55,800 TRAINEES CAN HAVE PRODUCTIVE 3253 02:17:55,800 --> 02:17:59,280 CAREERS, RESEARCH CAREERS IN 3254 02:17:59,280 --> 02:17:59,720 PHARMA. 3255 02:17:59,720 --> 02:18:01,920 THAT'S RELATED TO ORAL BIOLOGY. 3256 02:18:01,920 --> 02:18:04,960 WE'LL ALSO HAVE INFORMATION 3257 02:18:04,960 --> 02:18:08,000 SESSIONS FROM LEADERS OF 3258 02:18:08,000 --> 02:18:09,200 PROGRAMS, THESE ARE TRAINING 3259 02:18:09,200 --> 02:18:12,040 PROGRAMS AND OTHER INSTITUTES AT 3260 02:18:12,040 --> 02:18:12,200 NIH. 3261 02:18:12,200 --> 02:18:15,320 WE HAVE WRITTEN A REQUEST FOR 3262 02:18:15,320 --> 02:18:18,320 INFORMATION WHICH HAS BEEN 3263 02:18:18,320 --> 02:18:20,000 VETTED BY NIDCR NOW AND FOR 3264 02:18:20,000 --> 02:18:21,680 PUBLIC COMMENT ON TRAINING 3265 02:18:21,680 --> 02:18:24,280 PROGRAMS AND WE'VE ASKED THE 3266 02:18:24,280 --> 02:18:25,880 PUBLIC TO COMMENT ON THE 3267 02:18:25,880 --> 02:18:28,320 QUESTIONS WHICH I HAVE OUTLINED 3268 02:18:28,320 --> 02:18:28,520 HERE. 3269 02:18:28,520 --> 02:18:31,680 AND THEN WE WILL HAVE ADDITIONAL 3270 02:18:31,680 --> 02:18:33,480 STAKEHOLDER MEETINGS WITH 3271 02:18:33,480 --> 02:18:36,400 LISTENING SESSIONS AT THE 3272 02:18:36,400 --> 02:18:41,720 CONFERENCE IN MARCH AT AADOCR. 3273 02:18:41,720 --> 02:18:43,880 WE WILL THEN EVALUATE THE 3274 02:18:43,880 --> 02:18:47,680 INFORMATION THAT WE HAVE 3275 02:18:47,680 --> 02:18:49,800 RECEIVED AND OUR ACTION ITEMS 3276 02:18:49,800 --> 02:18:51,240 WILL BE ASSESSMENT OF FEEDBACK 3277 02:18:51,240 --> 02:18:52,680 FROM THE STAKEHOLDER GROUPS FROM 3278 02:18:52,680 --> 02:18:57,520 THE LISTENING SESSIONS AND AN 3279 02:18:57,520 --> 02:19:00,120 ASSESSMENT FROM THE ARFI WHICH 3280 02:19:00,120 --> 02:19:03,480 HAS BEEN DISSEMINATED TO THE 3281 02:19:03,480 --> 02:19:03,720 PUBLIC. 3282 02:19:03,720 --> 02:19:07,520 WE WILL EVALUATE CURRENT 3283 02:19:07,520 --> 02:19:08,760 INSTITUTIONAL PROGRAMS WITHIN 3284 02:19:08,760 --> 02:19:11,440 EMPHASIS ON SUCCESSES AND GAPS 3285 02:19:11,440 --> 02:19:17,120 AND WE WILL EVALUATE CURRENT 3286 02:19:17,120 --> 02:19:18,920 INDIVIDUAL PROGRAMS EVALUATING 3287 02:19:18,920 --> 02:19:20,240 SUCCESSES AND GAPS. 3288 02:19:20,240 --> 02:19:23,200 ONE OF THE IMPORTANT AREAS OF 3289 02:19:23,200 --> 02:19:25,600 INVESTIGATION AND ACTION WILL BE 3290 02:19:25,600 --> 02:19:28,200 WHAT TYPES OF PROGRAMS ARE MOST 3291 02:19:28,200 --> 02:19:28,880 SUCCESSFUL? 3292 02:19:28,880 --> 02:19:30,320 WHAT GIVES OUTCOMES THAT ARE 3293 02:19:30,320 --> 02:19:34,080 MOST PRODUCTIVE AND ONE 3294 02:19:34,080 --> 02:19:35,400 COMPARISON IS INSTITUTION 3295 02:19:35,400 --> 02:19:38,320 PROGRAMS VERSUS INDIVIDUAL 3296 02:19:38,320 --> 02:19:45,240 PROGRAMS WHERE THE APPLICANT 3297 02:19:45,240 --> 02:19:46,840 WRITES AN AWARD FOR FUNDING AND 3298 02:19:46,840 --> 02:19:48,320 WE WILL MAKE RECOMMENDATIONS TO 3299 02:19:48,320 --> 02:19:50,400 THE COUNCIL ON BOTH INDIVIDUAL 3300 02:19:50,400 --> 02:19:53,760 AND INSTITUTION BASED PROGRAMS 3301 02:19:53,760 --> 02:19:56,640 AND EMBEDDED IN ALL OF THESE 3302 02:19:56,640 --> 02:19:57,680 RECOMMENDATIONS WILL BE THE 3303 02:19:57,680 --> 02:20:01,080 CONCEPT OF INCREASING DIVERSITY 3304 02:20:01,080 --> 02:20:11,320 AND INCLUSION. 3305 02:20:15,880 --> 02:20:18,400 THIS WOULD INCLUDE ELEMENTARY 3306 02:20:18,400 --> 02:20:21,440 SCHOOL GOING FORWARD TO 3307 02:20:21,440 --> 02:20:23,760 ESPECIALLY UNDER REPRESENTED 3308 02:20:23,760 --> 02:20:26,120 COMMUNITIES WHO MAKE THE 3309 02:20:26,120 --> 02:20:28,600 STUDENTS AWARE THAT THERE ARE 3310 02:20:28,600 --> 02:20:30,640 OPPORTUNITIES FOR RESEARCH IN 3311 02:20:30,640 --> 02:20:34,600 ORAL HEALTH OR CRANIAL RESEARCH. 3312 02:20:34,600 --> 02:20:36,480 WE WILL DEVELOP NEW PROGRAMS TO 3313 02:20:36,480 --> 02:20:40,920 INCLUDE AND SUPPORT DOCTORAL OR 3314 02:20:40,920 --> 02:20:43,480 CANDIDATES FOR DOC RESEARCH AS 3315 02:20:43,480 --> 02:20:45,080 WELL AS DEVELOP NEW PROGRAMS TO 3316 02:20:45,080 --> 02:20:49,520 RECRUIT, SUPPORT AND RETAIN 3317 02:20:49,520 --> 02:20:52,040 POSTDOCS, NOT TRADITIONAL PH.D 3318 02:20:52,040 --> 02:20:54,160 OR FACULTY THAT ARE IN DOM 3319 02:20:54,160 --> 02:20:55,080 RESEARCH ALREADY. 3320 02:20:55,080 --> 02:20:59,720 THE NONTRADITIONAL RESEARCH IN 3321 02:20:59,720 --> 02:21:04,160 TERMS OF DOC REPRESENTS BIO 3322 02:21:04,160 --> 02:21:05,800 BIO-INFORMATICS, ENGINEERING AND 3323 02:21:05,800 --> 02:21:09,000 OTHER FIELDS WHERE THERE'S A 3324 02:21:09,000 --> 02:21:10,320 NATURAL RELATIONSHIP TO DENTAL 3325 02:21:10,320 --> 02:21:13,320 AND ORAL CRANE CRASH FACIAL 3326 02:21:13,320 --> 02:21:13,600 RESEARCH. 3327 02:21:13,600 --> 02:21:18,920 AS WELL AS CLINICAL RESEARCH. 3328 02:21:18,920 --> 02:21:22,200 WE WILL DEVELOP METRICS TO 3329 02:21:22,200 --> 02:21:24,240 ACCESSORY SEARCH TRAINING 3330 02:21:24,240 --> 02:21:28,720 PROGRAMS AND TO ACCESSORY 3331 02:21:28,720 --> 02:21:29,480 TENSION PROGRAMS. 3332 02:21:29,480 --> 02:21:36,320 WE WILL ADDRESS ISSUES OF 3333 02:21:36,320 --> 02:21:37,400 TRAINEE RESEARCH AS WELL AS 3334 02:21:37,400 --> 02:21:39,280 CAPACITY AND THIS WILL PROVIDE 3335 02:21:39,280 --> 02:21:40,280 DATABASES AND INFORMATION FOR 3336 02:21:40,280 --> 02:21:43,280 THOSE WHO ARE INTERESTED AS WELL 3337 02:21:43,280 --> 02:21:50,800 AS PROVIDE A PATH FOR THEM TO 3338 02:21:50,800 --> 02:21:54,000 FOLLOW. 3339 02:21:54,000 --> 02:21:54,840 SO THEY HAVE STRUCTURE OF WHAT 3340 02:21:54,840 --> 02:21:55,800 IS AVAILABLE. 3341 02:21:55,800 --> 02:21:58,760 WE'LL ALSO PROMOTE RESEARCH OR 3342 02:21:58,760 --> 02:22:00,160 DEVELOP PROGRAMS THAT PROMOTE 3343 02:22:00,160 --> 02:22:03,800 RESEARCH IN TRAINING AREAS THAT 3344 02:22:03,800 --> 02:22:05,600 WILL ALIGN WITH THE STRATEGIC 3345 02:22:05,600 --> 02:22:07,680 PLAN AND THAT'S BEEN OUTLINED 3346 02:22:07,680 --> 02:22:10,240 ALREADY AND INCLUDES THE PAIN 3347 02:22:10,240 --> 02:22:13,320 RESEARCH OF BIG DATA AND 3348 02:22:13,320 --> 02:22:17,240 TRANSLATIONAL RESEARCH AND SO ON 3349 02:22:17,240 --> 02:22:19,240 AND WILL ALSO DEVELOP TRAINING 3350 02:22:19,240 --> 02:22:21,480 PROGRAMS SO THAT TRAINEES ARE 3351 02:22:21,480 --> 02:22:23,000 EXPOSED TO EMERGING AND CUTTING 3352 02:22:23,000 --> 02:22:27,880 EDGE RESEARCH. 3353 02:22:27,880 --> 02:22:29,160 IT MIGHT GO BEYOND WHAT THEY 3354 02:22:29,160 --> 02:22:30,880 WOULD RECEIVE IN THEIR DEGREE 3355 02:22:30,880 --> 02:22:31,320 PROGRAMS. 3356 02:22:31,320 --> 02:22:32,920 SO WITH THAT I WOULD LIKE TO 3357 02:22:32,920 --> 02:22:35,960 SAY, THANK YOU AND TO REASSURE 3358 02:22:35,960 --> 02:22:37,720 EVERYONE THAT WE WILL BE WORKING 3359 02:22:37,720 --> 02:22:46,560 VERY DILIGENT LEON THIS TOPIC. 3360 02:22:46,560 --> 02:22:47,960 THANK YOU Dr. GRAVES, ARE 3361 02:22:47,960 --> 02:22:55,560 THERE ANY COMMENTS OR QUESTIONS. 3362 02:22:55,560 --> 02:23:00,480 NO ONE HAS ANY THOUGHTS? 3363 02:23:00,480 --> 02:23:09,280 COMMENTS ON THE WORKING GROUP. 3364 02:23:09,280 --> 02:23:13,960 >> I DO HAVE ONE IF I COULD. 3365 02:23:13,960 --> 02:23:17,840 I MEAN, LOOKING AT THE ENTIRE 3366 02:23:17,840 --> 02:23:20,000 HISTORY OF TRAINING WOULD BE 3367 02:23:20,000 --> 02:23:21,560 PROBABLY A LITTLE BIT TOO 3368 02:23:21,560 --> 02:23:25,120 AMBITIOUS BECAUSE IT WAS IN JIM 3369 02:23:25,120 --> 02:23:26,520 LIPTON'S TIME HOW THEY WERE 3370 02:23:26,520 --> 02:23:28,760 HANDLED BUT, HOWEVER I WAS MORE 3371 02:23:28,760 --> 02:23:30,120 CURIOUS AS TO HOW THE BALANCE 3372 02:23:30,120 --> 02:23:32,120 WOULD BE CREATED AND IN KIND OF 3373 02:23:32,120 --> 02:23:35,400 ALMOST TAKING FOR GRANTED WHAT 3374 02:23:35,400 --> 02:23:36,960 THE GLITCHES ARE WHICH ARE 3375 02:23:36,960 --> 02:23:38,720 OBVIOUS, RIGHT, HIGH TUITION, 3376 02:23:38,720 --> 02:23:41,800 LONG TRAINING PROGRAMS FOR 3377 02:23:41,800 --> 02:23:44,200 DDSBHDs AND PROJECTS THAT THEY 3378 02:23:44,200 --> 02:23:45,840 NOT ALWAYS CAN CREE LATE TO IN 3379 02:23:45,840 --> 02:23:48,480 TERMS OF THEIR CLINICAL SKILLS. 3380 02:23:48,480 --> 02:23:49,920 THERE'S ALL OF THESE THAT ARE 3381 02:23:49,920 --> 02:23:50,800 PRETTY OBVIOUS. 3382 02:23:50,800 --> 02:23:53,080 WOULD YOU BE BALANCING IT OUT 3383 02:23:53,080 --> 02:23:56,520 MORE WITH LOOKING AT OUTCOMES OF 3384 02:23:56,520 --> 02:23:58,760 RETURN OF INVESTMENTS SO WE CAN 3385 02:23:58,760 --> 02:24:01,520 REALLY LOOK TO THE FUTURE WITH A 3386 02:24:01,520 --> 02:24:03,320 REVISED SET OF GOALS? 3387 02:24:03,320 --> 02:24:04,320 I DON'T KNOW HOW WOULD YOU DO 3388 02:24:04,320 --> 02:24:05,880 THAT BECAUSE IF IT'S A VERY -- 3389 02:24:05,880 --> 02:24:08,600 IT'S A LABOR INTENSE PROCESS. 3390 02:24:08,600 --> 02:24:14,200 >> YES, SO, I LAID OUT PRE 3391 02:24:14,200 --> 02:24:16,000 TEMPORAL TRANSITIONS THAT WE 3392 02:24:16,000 --> 02:24:18,320 WILL UNDERTAKE AND THE FIRST 3393 02:24:18,320 --> 02:24:19,920 WILL BE INFORMATION GATHERING 3394 02:24:19,920 --> 02:24:21,720 THE INFORMATION AND THEN THE 3395 02:24:21,720 --> 02:24:23,880 SECOND PHASE WILL BE EVALUATING 3396 02:24:23,880 --> 02:24:26,280 IT AND ONE OF THE KEY THINGS IS 3397 02:24:26,280 --> 02:24:29,680 TO EVALUATE WHAT ENABLES A 3398 02:24:29,680 --> 02:24:31,400 PERSON OR STUDENTS TO 3399 02:24:31,400 --> 02:24:33,280 SUCCESSFULLY TRANSITION TO A 3400 02:24:33,280 --> 02:24:35,320 RESEARCH CAREER FROM BEING A 3401 02:24:35,320 --> 02:24:35,800 STUDENT. 3402 02:24:35,800 --> 02:24:38,160 HOW DO YOU OPEN DOORS AND I 3403 02:24:38,160 --> 02:24:44,000 EXPECT WE'LL BE LOOKING AT HOW 3404 02:24:44,000 --> 02:24:45,880 DO YOU INCENTIVIZE MENTORS 3405 02:24:45,880 --> 02:24:49,840 BECAUSE THEY OPEN THE DOORS FOR 3406 02:24:49,840 --> 02:24:58,400 THE STUDENTS NOTHING FURTHER 3407 02:24:58,400 --> 02:25:00,640 PEOPLE INTEND TO BE DENTISTS NOT 3408 02:25:00,640 --> 02:25:01,480 RESEARCHERS BUT THESE STORIES 3409 02:25:01,480 --> 02:25:03,320 ARE OPEN SO TO YOU DO YOU MAKE 3410 02:25:03,320 --> 02:25:05,080 PEOPLE OR STUDENTS AWARE THAT 3411 02:25:05,080 --> 02:25:11,520 THEY HAVE THESE OPPORTUNITIES 3412 02:25:11,520 --> 02:25:12,560 AND THEY ARE WELL ESTABLISHED 3413 02:25:12,560 --> 02:25:14,480 AND OUR OWN RISK SO I THINK THAT 3414 02:25:14,480 --> 02:25:23,760 WHEN WE EVALUATE THAT WILL BE A 3415 02:25:23,760 --> 02:25:30,120 DIVAC OR. 3416 02:25:30,120 --> 02:25:32,080 >> ANYONE ELSE? 3417 02:25:32,080 --> 02:25:34,880 >> WELL, IF NOT -- 3418 02:25:34,880 --> 02:25:37,480 >> I WOULD MAKE A COMMENT, 3419 02:25:37,480 --> 02:25:37,680 MAYBE. 3420 02:25:37,680 --> 02:25:39,360 >> AS I'M PREPARING THE 3421 02:25:39,360 --> 02:25:42,920 COMMITTEE WITH DANA, I THINK AS 3422 02:25:42,920 --> 02:25:44,520 WE MOVE THROUGH YOUR CAREER 3423 02:25:44,520 --> 02:25:45,600 SOMETIMES IT BECOMES OBVIOUS 3424 02:25:45,600 --> 02:25:46,680 THAT THERE'S NOTHING MORE 3425 02:25:46,680 --> 02:25:48,720 IMPORTANT THAN TRAINING THE NEXT 3426 02:25:48,720 --> 02:25:51,160 GENERATION SO I THINK WE'RE VERY 3427 02:25:51,160 --> 02:25:52,720 LUCKY TO HAVE THIS WORKING GROUP 3428 02:25:52,720 --> 02:25:56,400 AND I WANT TO THANK YOU FOR 3429 02:25:56,400 --> 02:25:58,200 ESTABLISHING IT AND DANA FOR 3430 02:25:58,200 --> 02:26:02,040 LEADING IT AND I THINK WE HAVE A 3431 02:26:02,040 --> 02:26:03,640 WONDERFUL GROUP AND I EXPECT 3432 02:26:03,640 --> 02:26:05,280 WE'LL HAVE SOME TERRIFIC 3433 02:26:05,280 --> 02:26:06,600 RECOMMENDATIONS THAT CAN REALLY 3434 02:26:06,600 --> 02:26:09,640 MOVE THE BAR AND I MY SO 3435 02:26:09,640 --> 02:26:11,480 SUBPOENA OF OBVIOUS BEEN 3436 02:26:11,480 --> 02:26:13,000 FRUSTRATED BY SEEING TALENTED 3437 02:26:13,000 --> 02:26:17,680 YOUNG SCIENTISTS IN OUR FIELD 3438 02:26:17,680 --> 02:26:28,200 WHO DON'T CONDITION SO THINGS 3439 02:26:36,120 --> 02:26:38,800 ARE A LITTLE WONKY BUT ANYWAY, 3440 02:26:38,800 --> 02:26:41,720 I'M HAPPY TO BE HERE AND THANK 3441 02:26:41,720 --> 02:26:41,880 YOU. 3442 02:26:41,880 --> 02:26:44,040 >> THANK YOU. 3443 02:26:44,040 --> 02:26:48,320 >> THANK YOU FOR THOSE COMMENTS. 3444 02:26:48,320 --> 02:26:51,040 >> THANK YOU SO MUCH FOR LEADING 3445 02:26:51,040 --> 02:26:53,160 THE WAY ON THIS AND IT SEEMS 3446 02:26:53,160 --> 02:26:56,240 LIKE IN THE RECORDING THE ARENA 3447 02:26:56,240 --> 02:26:57,320 PRESENTED WE ALREADY HAVE TWO 3448 02:26:57,320 --> 02:26:58,960 KIND OF MODEL PROGRAMS IN A 3449 02:26:58,960 --> 02:27:02,760 SENSE AND ONE IS THE FUNDED 3450 02:27:02,760 --> 02:27:04,640 ACTIVITIES THAT THE AVCOR HAS 3451 02:27:04,640 --> 02:27:06,520 WHICH IS FINE THE FUTURE PROGRAM 3452 02:27:06,520 --> 02:27:08,280 TO GRAB FOLKS RIGHT AT THAT 3453 02:27:08,280 --> 02:27:09,400 CHALLENGING PERIOD AND EARLY 3454 02:27:09,400 --> 02:27:11,800 STAGE IN THEIR CAREER AND NOW WE 3455 02:27:11,800 --> 02:27:13,800 HAVE THE PRIME PROGRAM RFA OUT 3456 02:27:13,800 --> 02:27:15,880 THERE BUT THOSE ARE TWO GREAT 3457 02:27:15,880 --> 02:27:17,200 EXAMPLES POTENTIALLY THAT COULD 3458 02:27:17,200 --> 02:27:19,080 FIT RIGHT INTO WHAT YOUR 3459 02:27:19,080 --> 02:27:20,280 WORKGROUP IS FOCUSING ON. 3460 02:27:20,280 --> 02:27:24,080 >> I ALSO THINK THAT THEY 3461 02:27:24,080 --> 02:27:34,600 REPRESENT PARTNERSHIPS WHICH IS 3462 02:27:35,880 --> 02:27:37,240 PART OF THIS AND THE DENTAL 3463 02:27:37,240 --> 02:27:38,800 SCHOOLS NEED TO BE PART OF THIS 3464 02:27:38,800 --> 02:27:40,040 THAT'S WHY WE'RE HAVING 3465 02:27:40,040 --> 02:27:41,880 INFORMATION SESSIONS WITH DEANS 3466 02:27:41,880 --> 02:27:44,840 EX CHAIRS TO GET WHAT DO THEY 3467 02:27:44,840 --> 02:27:45,920 WANT IN? 3468 02:27:45,920 --> 02:27:47,960 WHAT TYPE OF DIALOGUE NEEDS TO 3469 02:27:47,960 --> 02:27:52,240 TAKE PLACE SO IS THAT THEY CAN 3470 02:27:52,240 --> 02:27:56,880 NURTURE A STUDENT. 3471 02:27:56,880 --> 02:27:59,600 >> YEAH, OBVIOUSLY, YOU KNOW, 3472 02:27:59,600 --> 02:28:01,160 THE I REMEMBER LARRY TABAK 3473 02:28:01,160 --> 02:28:04,480 SHARING HA HE HAD THAT MEETING 3474 02:28:04,480 --> 02:28:05,440 WITH DEAN'S COUNCIL AND HE SAID 3475 02:28:05,440 --> 02:28:06,720 THE JOB OPPORTUNITIES LION 3476 02:28:06,720 --> 02:28:07,800 SPECIALTY DEPARTMENTS AND THAT 3477 02:28:07,800 --> 02:28:08,840 IS TRUE. 3478 02:28:08,840 --> 02:28:10,640 EVEN UNTIL TODAY. 3479 02:28:10,640 --> 02:28:13,160 BUT YOU CAN HAVE A DDS AND A 3480 02:28:13,160 --> 02:28:15,120 PH.D AND STILL BE IN A SPECIALTY 3481 02:28:15,120 --> 02:28:16,400 DEPARTMENT YOU DON'T HAVE TO 3482 02:28:16,400 --> 02:28:17,800 HAVE A SPECIALTY BECAUSE WHAT 3483 02:28:17,800 --> 02:28:19,240 THAT DOES IS MEET THE NEEDS OF 3484 02:28:19,240 --> 02:28:20,720 THE IMMEDIATE NEEDS OF THE 3485 02:28:20,720 --> 02:28:24,080 DEPARTMENT AT HAND AND YOU LAND 3486 02:28:24,080 --> 02:28:26,080 OF DILUTING OUT YOUR TIME IN THE 3487 02:28:26,080 --> 02:28:26,240 LAB. 3488 02:28:26,240 --> 02:28:28,680 I HOPE YOU WILL GIVE IT A REAL 3489 02:28:28,680 --> 02:28:30,280 BROAD SWEEP AND DEEP AS WELL. 3490 02:28:30,280 --> 02:28:33,240 DIVE DEEP AS WELL. 3491 02:28:33,240 --> 02:28:35,520 THANK YOU. 3492 02:28:35,520 --> 02:28:36,800 AND CREATIVE. 3493 02:28:36,800 --> 02:28:37,160 YES. 3494 02:28:37,160 --> 02:28:39,160 >> THANK YOU. 3495 02:28:39,160 --> 02:28:42,400 >> THANK YOU. 3496 02:28:42,400 --> 02:28:45,520 >> LYNN, CAN I JUST KEEP 3497 02:28:45,520 --> 02:28:47,680 INTERRUPTING BUT IF YOU ALL HAVE 3498 02:28:47,680 --> 02:28:49,480 IDEAS HOW WE CAN FULLY LEVERAGE 3499 02:28:49,480 --> 02:28:52,560 AND CAPITALIZE ON OUR TRAINING 3500 02:28:52,560 --> 02:28:53,640 CELEBRATIONS, OUR CELEBRATIONS 3501 02:28:53,640 --> 02:28:56,320 OF OUR TRAINEES FOR OUR 75t 3502 02:28:56,320 --> 02:29:00,320 75th IN OCTOBER OF NEXT YEAR, 3503 02:29:00,320 --> 02:29:02,000 PLEASE DO FEEL IT IN AND IT WILL 3504 02:29:02,000 --> 02:29:04,120 BE BASED ON WHAT YOU GATHER AS 3505 02:29:04,120 --> 02:29:04,360 DATA. 3506 02:29:04,360 --> 02:29:06,280 WE COULD HAVE BREAKOUT SESSIONS, 3507 02:29:06,280 --> 02:29:07,800 MENTORING, LUNCHES AND THINGS 3508 02:29:07,800 --> 02:29:08,240 LIKE THAT. 3509 02:29:08,240 --> 02:29:11,840 >> YEAH, WE CAN TALK ABOUT THAT 3510 02:29:11,840 --> 02:29:14,560 EVENT WITH A WORKING GROUP AND 3511 02:29:14,560 --> 02:29:17,920 SEE WHAT THEY MIGHT HAVE. 3512 02:29:17,920 --> 02:29:19,480 WHAT THEY WOULD LIKE TO ENGAGE 3513 02:29:19,480 --> 02:29:20,840 IN TOO SO THAT'S A GREAT IDEA. 3514 02:29:20,840 --> 02:29:28,240 >> THANK YOU. 3515 02:29:28,240 --> 02:29:29,280 >> Lynn M. King: SO MOVING ON WE 3516 02:29:29,280 --> 02:29:32,800 HAVE Dr. BRUCE DONOFF. 3517 02:29:32,800 --> 02:29:34,120 YOU HEARD HIS INTRODUCTION 3518 02:29:34,120 --> 02:29:35,760 EARLIER ON REDESIGNING AND 3519 02:29:35,760 --> 02:29:37,760 IMPROVING HEALTHCARE THROUGH 3520 02:29:37,760 --> 02:29:42,560 INTEGRATION OF ORAL AND MEDICAL 3521 02:29:42,560 --> 02:29:48,200 RESEARCH AND PRACTICE. 3522 02:29:48,200 --> 02:29:49,200 >> THANK YOU, VERY MUCH. 3523 02:29:49,200 --> 02:29:52,000 IF SOMEONE CAN PUT UP MY SLIDES. 3524 02:29:52,000 --> 02:29:54,240 I AM VERY HONORED AND PLEASED TO 3525 02:29:54,240 --> 02:29:57,800 HAVE BEEN ASKED TO ADDRESS THIS. 3526 02:29:57,800 --> 02:30:00,280 I'M SITTING HERE, I'M TRYING TO 3527 02:30:00,280 --> 02:30:02,640 THINK DOES OMB2 STILL EXIST. 3528 02:30:02,640 --> 02:30:05,680 I USED TO SERVE ON OMB2. 3529 02:30:05,680 --> 02:30:06,080 [LAUGHTER] 3530 02:30:06,080 --> 02:30:09,680 >> THAT DATES YOU. 3531 02:30:09,680 --> 02:30:12,560 >> SO, I'D LIKE TO START BY 3532 02:30:12,560 --> 02:30:16,200 QUOTING THE PAPER THAT RENA AND 3533 02:30:16,200 --> 02:30:18,880 SUSAN, FRANCIS COLLINS AND THEY 3534 02:30:18,880 --> 02:30:21,400 HAD IN THE NEW ENGLAND JOURNAL 3535 02:30:21,400 --> 02:30:31,960 BACK IN MARCH AND IT'S CRITICAL 3536 02:30:34,440 --> 02:30:35,640 THAT WE BUILD ON THIS KNOWLEDGE 3537 02:30:35,640 --> 02:30:38,280 AND THE SCIENTIFIC PROGRESS WE 3538 02:30:38,280 --> 02:30:40,720 MADE TO ENSURE THAT ORAL HEALTH 3539 02:30:40,720 --> 02:30:43,760 IS FULLY INTEGRATED INTO THIS 3540 02:30:43,760 --> 02:30:48,120 NEW ERA OF DISCOVERY AND TO 3541 02:30:48,120 --> 02:30:50,720 HARNESS POLICY CHANGES AND 3542 02:30:50,720 --> 02:30:54,080 TECHNOLOGICAL DISADVANTAGES TO 3543 02:30:54,080 --> 02:30:55,920 DISRUPT SYSTEMIC INEQUITIES. 3544 02:30:55,920 --> 02:30:59,760 ONLY THEN WILL WE TRULY IMPROVE 3545 02:30:59,760 --> 02:31:02,320 THE HEALTH OF PEOPLE, FAMILIES 3546 02:31:02,320 --> 02:31:08,720 AND COMMUNITIES AND I BELIEVE 3547 02:31:08,720 --> 02:31:09,080 THAT. 3548 02:31:09,080 --> 02:31:10,480 SO I WILL TALK ABOUT REDESIGNING 3549 02:31:10,480 --> 02:31:12,720 AND IMPROVING HEALTHCARE BY 3550 02:31:12,720 --> 02:31:15,680 INTEGRATED ORAL AND MEDICAL 3551 02:31:15,680 --> 02:31:16,920 RESEARCH AND PRACTICE SOMETHING 3552 02:31:16,920 --> 02:31:23,640 I AM QUITE PASSIONATE ABOUT. 3553 02:31:23,640 --> 02:31:26,760 INNOVATION, HAS ITS ENEMIES AND 3554 02:31:26,760 --> 02:31:28,280 VERY OFTEN ORGANIZED HEALTHCARE 3555 02:31:28,280 --> 02:31:31,240 GROUPS ARE THE ENEMIES, WHETHER 3556 02:31:31,240 --> 02:31:33,280 IT'S THE AMERICAN MEDICAL 3557 02:31:33,280 --> 02:31:34,720 ASSOCIATION OR THE AMERICAN 3558 02:31:34,720 --> 02:31:37,400 DENTAL ASSOCIATION. 3559 02:31:37,400 --> 02:31:39,920 SO THE REAL QUESTION, IS CAN HE 3560 02:31:39,920 --> 02:31:42,960 WE CREATE DENTAL MEDICAL 3561 02:31:42,960 --> 02:31:43,800 CHAMPIONS FOR CHANGE. 3562 02:31:43,800 --> 02:31:46,200 IN FACT, I THINK YOU INTRODUCED 3563 02:31:46,200 --> 02:31:49,880 ONE AT YOUR OWN INSTITUTE, 3564 02:31:49,880 --> 02:31:52,720 SOMEONE I KNOW, AND THAT IS 3565 02:31:52,720 --> 02:31:53,560 JANICE LEE. 3566 02:31:53,560 --> 02:31:56,360 SO WHAT I WOULD LIKE TO DO IS 3567 02:31:56,360 --> 02:31:57,680 REVIEW THE HISTORY. 3568 02:31:57,680 --> 02:31:58,840 MORE RECENT DISCUSSIONS ABOUT 3569 02:31:58,840 --> 02:32:01,200 THIS TOPIC AND THE POS ABILITIES 3570 02:32:01,200 --> 02:32:11,440 FOR CHANGE NOW. 3571 02:32:17,520 --> 02:32:18,800 SO, I THINK ONE OF THE THINGS 3572 02:32:18,800 --> 02:32:20,560 THAT WE HAVE TO CONSIDER IN 3573 02:32:20,560 --> 02:32:22,880 DOING THIS IS CHANGING THE SCOPE 3574 02:32:22,880 --> 02:32:24,520 OF DEPARTMENTAL PRACTICE. 3575 02:32:24,520 --> 02:32:26,520 I THINK THAT THERE'S A PLACE FOR 3576 02:32:26,520 --> 02:32:28,440 OLYMPIC ORAL HEALTH AND PRIMARY 3577 02:32:28,440 --> 02:32:30,080 CARE AND I THINK WE NEED TO 3578 02:32:30,080 --> 02:32:32,720 THINK OF CHANGE VERSUS 3579 02:32:32,720 --> 02:32:34,720 CONTINUITY AND WE NEED TO THINK 3580 02:32:34,720 --> 02:32:36,600 OF INNOVATION VERSUS INKUM BEN 3581 02:32:36,600 --> 02:32:40,080 SEE AND TWO OF MY FAVORITE AREAS 3582 02:32:40,080 --> 02:32:42,240 DISRUPTIVE INNOVATION, WHICH WAS 3583 02:32:42,240 --> 02:32:48,680 THE BRAINCHILD OF CLAY 3584 02:32:48,680 --> 02:32:59,040 CHRISTIANSON. 3585 02:32:59,040 --> 02:33:00,520 AND IN CERTAIN OF THOSE CHANGES 3586 02:33:00,520 --> 02:33:02,760 I'M REMINDED THAT ABOUT TWO AND 3587 02:33:02,760 --> 02:33:05,400 A HALF YEARS AGO, THE AMERICAN 3588 02:33:05,400 --> 02:33:07,680 DENTAL ASSOCIATION HAD AN 3589 02:33:07,680 --> 02:33:09,400 ANNOUNCEMENT THAT SAID THAT ALL 3590 02:33:09,400 --> 02:33:13,560 DENTISTS SHOULD ADVOCATE FOR 3591 02:33:13,560 --> 02:33:16,880 PATIENTS GETTING HPV 3592 02:33:16,880 --> 02:33:17,480 VACCINATIONS. 3593 02:33:17,480 --> 02:33:19,280 AND MY RESPONSE TO THAT IS, WHY 3594 02:33:19,280 --> 02:33:23,760 DON'T DENTISTS GIVE HPV 3595 02:33:23,760 --> 02:33:25,480 VACCINATIONS? 3596 02:33:25,480 --> 02:33:33,760 WE GIVE BIG MAN DIBULA BLOCKS. 3597 02:33:33,760 --> 02:33:35,160 LET'S RETURN TO A HISTORY OF 3598 02:33:35,160 --> 02:33:36,840 THIS TOPIC IN THE UNITED STATES. 3599 02:33:36,840 --> 02:33:38,360 THE BALTIMORE COLLEGE OF 3600 02:33:38,360 --> 02:33:41,520 DENTISTRY WAS THE FIRST DENTAL 3601 02:33:41,520 --> 02:33:43,200 SCHOOL IN AMERICA. 3602 02:33:43,200 --> 02:33:45,200 WHAT IF IT HAD BECOME PART OF 3603 02:33:45,200 --> 02:33:47,360 THE UNIVERSITY OF MARYLAND 3604 02:33:47,360 --> 02:33:49,040 MEDICAL SCHOOL, NO ONE IS QUITE 3605 02:33:49,040 --> 02:33:52,240 SURE IF THE DENTISTS ORIGINATORS 3606 02:33:52,240 --> 02:33:53,800 DIDN'T WANT TO JOIN OR THE 3607 02:33:53,800 --> 02:33:55,880 MEDICAL SCHOOL DIDN'T WANT THEM. 3608 02:33:55,880 --> 02:33:58,480 BUT JUST THINK OF WHAT WOULD BE 3609 02:33:58,480 --> 02:34:00,640 DIFFERENT IF THAT DENTAL SCHOOL 3610 02:34:00,640 --> 02:34:02,400 WAS PART OF THE MEDICAL SCHOOL. 3611 02:34:02,400 --> 02:34:04,880 NEXT, WE HAD MY OWN INSTITUTION, 3612 02:34:04,880 --> 02:34:06,640 THE HARVARD DENTAL SCHOOL WHICH 3613 02:34:06,640 --> 02:34:10,440 CAUSED ALL SORTS OF PROBLEMS IN 3614 02:34:10,440 --> 02:34:12,480 1867 BY FORMING A DENTAL SCHOOL 3615 02:34:12,480 --> 02:34:15,200 AND GIVING A DMD DEGREE. 3616 02:34:15,200 --> 02:34:25,360 HOW SILLY. 3617 02:35:14,440 --> 02:35:16,240 >> SO THERE ARE ATTEMPTS THROUGH 3618 02:35:16,240 --> 02:35:19,080 THE YEARS AND JUST A QUICK 3619 02:35:19,080 --> 02:35:20,640 REVIEW, THE GUYS REPORT SAID 3620 02:35:20,640 --> 02:35:23,120 THAT DENTISTRY SHOULD ALWAYS BE 3621 02:35:23,120 --> 02:35:25,600 ALIGN FROM SEPARATE FROM 3622 02:35:25,600 --> 02:35:25,880 MEDICINE. 3623 02:35:25,880 --> 02:35:30,880 LITTLE GUYS WAS . CHEMIST AT 3624 02:35:30,880 --> 02:35:31,160 COLOMBIA. 3625 02:35:31,160 --> 02:35:33,440 ALFRED OWRE WAS THE DEAN AT 3626 02:35:33,440 --> 02:35:33,720 COLOMBIA. 3627 02:35:33,720 --> 02:35:35,440 HE WAS A DUEL-DEGREE DENTIST AND 3628 02:35:35,440 --> 02:35:38,480 HE WAS PASSIONATE ABOUT MEDICAL, 3629 02:35:38,480 --> 02:35:39,560 DENTAL INTEGRATION AND GUESS 3630 02:35:39,560 --> 02:35:41,720 WHAT HAPPENED, THE FIRST 3631 02:35:41,720 --> 02:35:43,800 DIRECTING DENTAL SOCIETY OF NEW 3632 02:35:43,800 --> 02:35:48,560 YORK CITY RAN HIM OUT OF TOWN. 3633 02:35:48,560 --> 02:35:55,800 IN THE 1930s AND LATE 1940s 3634 02:35:55,800 --> 02:35:56,480 DEAN FROM YALE MEDICAL SCHOOL 3635 02:35:56,480 --> 02:35:57,800 WAS VERY PROGRESSIVE AND 3636 02:35:57,800 --> 02:35:59,800 DEVELOPED AN MD PROGRAM FOR 3637 02:35:59,800 --> 02:36:01,640 DENTISTS AND HE FELT 3638 02:36:01,640 --> 02:36:03,920 SPECIFICALLY IT WOULD IMPROVE 3639 02:36:03,920 --> 02:36:04,840 THEIR KNOWLEDGE AND ABILITY TO 3640 02:36:04,840 --> 02:36:15,040 DO RESEARCH. 3641 02:36:17,880 --> 02:36:19,320 THAT EXPERIMENTS ARE IMPORTANT 3642 02:36:19,320 --> 02:36:23,200 AND PILOT PROGRAMS ARE 3643 02:36:23,200 --> 02:36:23,680 IMPORTANT. 3644 02:36:23,680 --> 02:36:24,840 SO JUST THREE PEOPLE CAME OUT OF 3645 02:36:24,840 --> 02:36:27,880 THAT PROGRAM, LESTER BURKETT 3646 02:36:27,880 --> 02:36:31,600 FROM THE UNIVERSITY OF 3647 02:36:31,600 --> 02:36:34,680 PENNSYLVANIA AND KRESHOVER WHO 3648 02:36:34,680 --> 02:36:37,200 BECAME A DIRECTOR OF THE NIDCR 3649 02:36:37,200 --> 02:36:40,880 AND DAVID WEISBERGER WHO WAS A 3650 02:36:40,880 --> 02:36:42,800 LEADER AND MY TEACHER AT 3651 02:36:42,800 --> 02:36:43,040 HARVARD. 3652 02:36:43,040 --> 02:36:45,160 AND THEN THERE WAS THE HARVARD 3653 02:36:45,160 --> 02:36:47,520 EXPERIMENT OF 1940 DEEM TO 3654 02:36:47,520 --> 02:36:48,720 FAILURE WHERE EVERYBODY COMING 3655 02:36:48,720 --> 02:36:52,640 INTO THE DENTAL SCHOOL GOT BOTH 3656 02:36:52,640 --> 02:36:55,040 AN M.D. AND A DMD AND THE VERY 3657 02:36:55,040 --> 02:36:58,360 SUCCESSFUL MGH ORAL AND FACIAL 3658 02:36:58,360 --> 02:37:02,880 SURGERY PROGRAM WHICH BEGAN IN 3659 02:37:02,880 --> 02:37:06,040 1961 AND WHICH NOW NUMBERS ABOUT 3660 02:37:06,040 --> 02:37:07,040 50 PLUS PROGRAMS MANY OF THE 3661 02:37:07,040 --> 02:37:08,440 IMPORTANT THING ABOUT THE LAST 3662 02:37:08,440 --> 02:37:11,040 PROGRAM IS, THAT PROGRAM CAME 3663 02:37:11,040 --> 02:37:14,440 ABOUT BECAUSE OF THE DESIRES OF 3664 02:37:14,440 --> 02:37:15,080 APPLICANTS. 3665 02:37:15,080 --> 02:37:17,480 IT WASN'T NECESSARY, THE DESIRES 3666 02:37:17,480 --> 02:37:20,240 OF ACADEMICS OR PEOPLE IN POWER. 3667 02:37:20,240 --> 02:37:24,520 THE NEXT, PLEASE. 3668 02:37:24,520 --> 02:37:26,160 THERE HAVE BEEN A NUMBER OF 3669 02:37:26,160 --> 02:37:29,360 REPORTS OF IMPORTANCE. 3670 02:37:29,360 --> 02:37:33,000 THE GIES REPORT WHICH I 3671 02:37:33,000 --> 02:37:34,040 MENTIONED, DENTAL APPLICATION 3672 02:37:34,040 --> 02:37:35,240 FROM THE CROSS ROADS FROM THE 3673 02:37:35,240 --> 02:37:38,200 PREVIOUS INSTITUTE OF MEDICINE 3674 02:37:38,200 --> 02:37:40,680 IN 1995 WAS A WONDERFUL REPORT 3675 02:37:40,680 --> 02:37:43,560 IN FACT, RECOMMENDING CERTAIN 3676 02:37:43,560 --> 02:37:46,960 CHANGES AND CERTAIN STABILITY IN 3677 02:37:46,960 --> 02:37:47,800 EDUCATION. 3678 02:37:47,800 --> 02:37:51,360 IT HAD ON ITS COLORS LAVENDER 3679 02:37:51,360 --> 02:37:53,640 AND GREEN, THE ACADEMIC COLORS 3680 02:37:53,640 --> 02:37:55,600 OF MEDICINE AND DENTISTRY BUT 3681 02:37:55,600 --> 02:37:57,680 STUDIES SHOWED THAT IT WAS READ 3682 02:37:57,680 --> 02:38:01,080 BY LESS THAN 15% OF PEOPLE IN 3683 02:38:01,080 --> 02:38:03,160 THE HEALTH PROFESSIONS. 3684 02:38:03,160 --> 02:38:07,080 AND THEN THERE WAS THE 21 CENTS 3685 02:38:07,080 --> 02:38:12,120 REGUYS REPORT LED BY ALAN FORMER 3686 02:38:12,120 --> 02:38:14,640 SUPPORTED BY THE ADA AND OTHER 3687 02:38:14,640 --> 02:38:16,480 GROUPS. 3688 02:38:16,480 --> 02:38:19,560 AND THAT WAS A VERY SUBSTANTIAL 3689 02:38:19,560 --> 02:38:22,880 REPORT BUT REALLY LED TO VERY 3690 02:38:22,880 --> 02:38:23,600 LITTLE CHANGES. 3691 02:38:23,600 --> 02:38:25,240 THERE WERE LOTS OF SUGGESTIONS 3692 02:38:25,240 --> 02:38:29,320 AND SOME REALLY KEY PLAYERS 3693 02:38:29,320 --> 02:38:31,720 INCLUDING LORI MCCAULEY AND 3694 02:38:31,720 --> 02:38:37,640 MYSELF AND OTHER PEOPLE WHO WERE 3695 02:38:37,640 --> 02:38:39,960 VERY WROTE PAPERS AND THE PEOPLE 3696 02:38:39,960 --> 02:38:41,920 AND THE AREA YOU ARE TRYING TO 3697 02:38:41,920 --> 02:38:44,600 CHANGE HAVE TO WANT TO CHANGE 3698 02:38:44,600 --> 02:38:46,440 AND THEN THERE WAS THE VERY 3699 02:38:46,440 --> 02:38:49,640 SUCCESSFUL ORAL HEALTH IN 3700 02:38:49,640 --> 02:38:51,440 AMERICAN REPORT THAT STARTED OUT 3701 02:38:51,440 --> 02:38:53,800 AS A SECOND SURGEON GENERAL'S 3702 02:38:53,800 --> 02:38:59,000 REPORT AND WAS EVENTUALLY ISSUED 3703 02:38:59,000 --> 02:38:59,440 THROUGH THE NIDCR. 3704 02:38:59,440 --> 02:39:02,160 ON THE RIGHT, IS A PAPER BY 3705 02:39:02,160 --> 02:39:04,440 HENDRICKSON AND PETER COHEN, 3706 02:39:04,440 --> 02:39:07,600 ORAL HEALTHCARE IN THE 21s 3707 02:39:07,600 --> 02:39:08,080 21st CENTURY. 3708 02:39:08,080 --> 02:39:09,480 IMPLICATIONS FOR DENTAL AND 3709 02:39:09,480 --> 02:39:10,360 MEDICAL EDUCATION. 3710 02:39:10,360 --> 02:39:12,640 THIS CAME OUT IN DECEMBER OF 3711 02:39:12,640 --> 02:39:15,400 2021 AND ACADEMIC MEDICINE AND 3712 02:39:15,400 --> 02:39:18,160 IN FACT, IT WAS THE LAST PAPER 3713 02:39:18,160 --> 02:39:21,040 ON THIS TOPIC THAT APPEARED IN A 3714 02:39:21,040 --> 02:39:23,400 MEDICAL EDUCATION JOURNAL. 3715 02:39:23,400 --> 02:39:26,880 THAT IS TELLING. 3716 02:39:26,880 --> 02:39:27,560 NEXT, PLEASE. 3717 02:39:27,560 --> 02:39:30,440 NOW, THERE ARE STRATEGIC 3718 02:39:30,440 --> 02:39:32,680 PRIORITIES AT THE NIDCR AND I'LL 3719 02:39:32,680 --> 02:39:34,120 HIGHLIGHT THIS PAPER WHICH 3720 02:39:34,120 --> 02:39:36,720 APPEARED IN FRONTIERS WHICH IS 3721 02:39:36,720 --> 02:39:39,400 AUTHORED BY Dr. MERIDIAN, 3722 02:39:39,400 --> 02:39:42,600 JANICE LEE, MARTHA SUMMERMAN AND 3723 02:39:42,600 --> 02:39:46,600 IT CALLED FOR THESE PRIORITIES 3724 02:39:46,600 --> 02:39:49,120 FOR THE NIDCR TO INTEGRATE ORAL 3725 02:39:49,120 --> 02:39:50,640 AND GENERAL HEALTH, DEVELOP 3726 02:39:50,640 --> 02:39:52,640 PRECISE AND INDIVIDUALIZED 3727 02:39:52,640 --> 02:39:55,960 TREATMENTS AND TRANSLATE AND 3728 02:39:55,960 --> 02:39:57,640 IMPLEMENT THAT NEW KNOWLEDGE AND 3729 02:39:57,640 --> 02:39:59,760 TO CREATE DIVERSE RESEARCH 3730 02:39:59,760 --> 02:40:02,160 PIPELINE AND TO PARTNER AND 3731 02:40:02,160 --> 02:40:04,440 COLLABORATE TO MAKE THAT PART OF 3732 02:40:04,440 --> 02:40:05,960 ONCE' BEING SO TO SPEAK. 3733 02:40:05,960 --> 02:40:08,240 THE OTHER THING I MUST SAY 3734 02:40:08,240 --> 02:40:10,360 HAVING SEEN THIS PRIMATE COME 3735 02:40:10,360 --> 02:40:12,680 OUT, WHEN I WOULD SEE MARTHA 3736 02:40:12,680 --> 02:40:14,560 SUMMERMAN IN A MEETING, SHE KNEW 3737 02:40:14,560 --> 02:40:18,800 HOW I FELT ABOUT THE PBRNs AND 3738 02:40:18,800 --> 02:40:20,240 SO SHE ALWAYS WOULD TRY AND 3739 02:40:20,240 --> 02:40:21,400 CHANGE THE SUBJECT. 3740 02:40:21,400 --> 02:40:24,240 SO REALLY, I'M REALLY HAPPY THAT 3741 02:40:24,240 --> 02:40:33,640 YOU ARE DOING -- NEXT SLIDE. 3742 02:40:33,640 --> 02:40:34,080 THANK YOU. 3743 02:40:34,080 --> 02:40:36,240 SO THE MAIN ISSUES FOR CHANGE 3744 02:40:36,240 --> 02:40:38,720 NOW, WHICH YOU HAVE HEARD ABOUT 3745 02:40:38,720 --> 02:40:40,120 BEFORE, AND WHICH I'LL TRY AND 3746 02:40:40,120 --> 02:40:42,880 MAKE THE POINT THAT A DUEL 3747 02:40:42,880 --> 02:40:44,840 DEGREE CAN HELP ACHIEVE, ACCESS 3748 02:40:44,840 --> 02:40:46,840 AND DISPARITIES OF CARE 3749 02:40:46,840 --> 02:40:50,440 PARTICULARLY THE UNDERSERVED 3750 02:40:50,440 --> 02:40:53,440 GROUPS AND THE ENDANGERED 3751 02:40:53,440 --> 02:40:55,360 SCIENTIST TO ADVANCE SIGNS AND 3752 02:40:55,360 --> 02:41:02,200 MEDICAL TREATMENT OF SURGICAL 3753 02:41:02,200 --> 02:41:12,720 DISEASE, TO TEACH ORAL HEALTH TO 3754 02:41:26,400 --> 02:41:27,440 MEDICAL STUDENTS AND RESIDENTS 3755 02:41:27,440 --> 02:41:29,200 BECAUSE I DO NOT THINK THAT 3756 02:41:29,200 --> 02:41:33,160 INTER PROFESSIONAL EDUCATION IS 3757 02:41:33,160 --> 02:41:36,040 DOING IT. 3758 02:41:36,040 --> 02:41:37,480 CHANGE IS CARD. 3759 02:41:37,480 --> 02:41:46,760 AND JUST I'M A STORY TELLER. 3760 02:41:46,760 --> 02:41:48,920 TALKED ABOUT HOW QUICKLY ETHER 3761 02:41:48,920 --> 02:41:50,320 ANESTHESIAIA, THE ANNIVERSARY OF 3762 02:41:50,320 --> 02:41:51,880 WHICH IS COMING UP IN OCTOBER, 3763 02:41:51,880 --> 02:41:54,200 HOW QUICKLY IT WAS ADOPTED BY 3764 02:41:54,200 --> 02:41:55,640 THE MEDICAL COMMUNITY. 3765 02:41:55,640 --> 02:41:59,760 AND IN THOSE DAYS, 1846, ABOUT 3766 02:41:59,760 --> 02:42:02,120 THE ONLY OPERATION THAT DID 3767 02:42:02,120 --> 02:42:03,400 SUCCESSFULLY WAS AM YOUTATIONS 3768 02:42:03,400 --> 02:42:05,840 BUT THAT WAS REALLY LATCHED ON 3769 02:42:05,840 --> 02:42:09,760 TO VERSUS LISTERS, IDEAS AN A 3770 02:42:09,760 --> 02:42:11,240 SEPSIS WHICH MEANT WORK FOR THE 3771 02:42:11,240 --> 02:42:12,640 DOCTORS AND WAS VERY SLOW AT 3772 02:42:12,640 --> 02:42:15,480 BEING ADOPTED. 3773 02:42:15,480 --> 02:42:17,640 I DRAW THE COMPARISON BETWEEN 3774 02:42:17,640 --> 02:42:25,480 TAKING CARE OF HIV AND IMPLANTS. 3775 02:42:25,480 --> 02:42:29,000 IMPLANTS WERE ADAPTED BY 3776 02:42:29,000 --> 02:42:31,040 WILDFIRE AND THE DENTAL 3777 02:42:31,040 --> 02:42:34,120 PROFESSION WAS SLOW TO DEAL WITH 3778 02:42:34,120 --> 02:42:36,840 HIV-INFECTED PATIENTS. 3779 02:42:36,840 --> 02:42:38,440 LINSK TALKED ABOUT ADAPTIVE 3780 02:42:38,440 --> 02:42:39,520 VERSUS TECHNICAL CHANGEMENT 3781 02:42:39,520 --> 02:42:41,640 WE'RE GOOD AT TECHNICAL CHANGE 3782 02:42:41,640 --> 02:42:43,760 BUT ADAPTIVE CHANGE IS 3783 02:42:43,760 --> 02:42:44,360 TRANSFORMATIVE AND THAT'S WHAT 3784 02:42:44,360 --> 02:42:46,040 YOU ARE TRYING TO DO AND THAT'S 3785 02:42:46,040 --> 02:42:47,920 WHAT I'M TRYING TO TALK ABOUT. 3786 02:42:47,920 --> 02:42:50,000 IT ALWAYS INVOLVES A LOSS FOR 3787 02:42:50,000 --> 02:42:52,720 SOMEONE AND THAT IS HARD FOR 3788 02:42:52,720 --> 02:42:54,280 PROFESSIONALS WHO HAVE BEEN AT 3789 02:42:54,280 --> 02:42:55,960 THEIR WORK FOR SOME TIME TAKING 3790 02:42:55,960 --> 02:42:59,680 GREAT CARE OF PATIENTS TO ADMIT. 3791 02:42:59,680 --> 02:43:05,520 SO TWO QUICK STORIES FROM 1973. 3792 02:43:05,520 --> 02:43:07,880 SECRETARY AT WAS A GREAT RACE 3793 02:43:07,880 --> 02:43:08,120 HORSE. 3794 02:43:08,120 --> 02:43:12,120 HE WON THE KENTUCKY DERBY AND HE 3795 02:43:12,120 --> 02:43:13,640 WON THE PREAKNESS AND HE STOPPED 3796 02:43:13,640 --> 02:43:13,920 TRAINING. 3797 02:43:13,920 --> 02:43:15,600 HE WOULDN'T RUN WELL AND THE 3798 02:43:15,600 --> 02:43:20,760 BELMONT WAS COMING UP AND HIS 3799 02:43:20,760 --> 02:43:21,840 TRAINER CALLED THE VET. 3800 02:43:21,840 --> 02:43:25,040 THE VET CAME TO SEE THE HORSE 3801 02:43:25,040 --> 02:43:27,280 AND FOUND A DENTAL ABSCESS. 3802 02:43:27,280 --> 02:43:30,400 THAT VET WASN'T RESTRICTED BY 3803 02:43:30,400 --> 02:43:31,320 ANY PRACTICE ACTS IN DOING WHAT 3804 02:43:31,320 --> 02:43:34,760 HE NEEDED TO DO TO TAKE CARE OF 3805 02:43:34,760 --> 02:43:36,720 THAT INFECTION. 3806 02:43:36,720 --> 02:43:38,960 HE DRAINED IT AND SECRETARIATE 3807 02:43:38,960 --> 02:43:42,760 BEGAN TO TRAIN AND EAT AND WON 3808 02:43:42,760 --> 02:43:44,560 THE BELMONT BY 23 FUR LONGS. 3809 02:43:44,560 --> 02:43:46,800 WHEN I WAS A MEDICAL STUDENT, I 3810 02:43:46,800 --> 02:43:49,880 WAS ASKED TO SEE A PATIENT AT A 3811 02:43:49,880 --> 02:43:54,320 PARTICULAR HARVARD HOSPITAL, WHO 3812 02:43:54,320 --> 02:43:57,000 HAD 105° FEVER, COMATOSE AND 3813 02:43:57,000 --> 02:43:58,440 THEY WERE SURE HE HAD MENINGITIS 3814 02:43:58,440 --> 02:43:59,400 BUT THEY COULDN'T FIND THE 3815 02:43:59,400 --> 02:44:00,920 SOURCE OF THE INFECTION. 3816 02:44:00,920 --> 02:44:03,080 WELL, LOW AND BEHOLD, LOOKING IN 3817 02:44:03,080 --> 02:44:08,000 THE MOUTH, DISCLOSED AN INFECTED 3818 02:44:08,000 --> 02:44:08,960 WISDOM TOOTH. 3819 02:44:08,960 --> 02:44:10,600 PHYSICIANS DON'T NECESSARILY 3820 02:44:10,600 --> 02:44:12,760 LOOK IN THE MOUTH AND THAT IS 3821 02:44:12,760 --> 02:44:14,200 WHAT MY CALL IS. 3822 02:44:14,200 --> 02:44:18,800 PUT THE MOUTH BACK IN THE BODY. 3823 02:44:18,800 --> 02:44:20,400 TALKING ABOUT SOME OF THE THINGS 3824 02:44:20,400 --> 02:44:24,360 IN DATABASES I REMEMBER WHEN THE 3825 02:44:24,360 --> 02:44:26,040 JUPITER TRIAL OF PROTEIN IN STAT 3826 02:44:26,040 --> 02:44:29,400 ENTERS CAME OUT, I MET WITH PAUL 3827 02:44:29,400 --> 02:44:30,600 RIDKA BECAUSE I WAS VERY 3828 02:44:30,600 --> 02:44:35,080 SURPRISED THAT THEY HAD IT 3829 02:44:35,080 --> 02:44:36,640 17,803 PATIENTS BUT NOT ONE 3830 02:44:36,640 --> 02:44:37,920 DENTIST WAS INVOLVED IN THE 3831 02:44:37,920 --> 02:44:38,120 STUDY. 3832 02:44:38,120 --> 02:44:43,560 THERE WAS NO EXAMINATION FOR 3833 02:44:43,560 --> 02:44:54,920 PERRY TONIGPERPERTONIGHTAL DISED 3834 02:44:57,200 --> 02:45:07,560 TO SEE ME -- EVERY LECTURE 3835 02:45:11,520 --> 02:45:12,840 STARTED WITH, WE DON'T SEE WHY 3836 02:45:12,840 --> 02:45:13,680 YOU SHOULD KNOW THIS. 3837 02:45:13,680 --> 02:45:14,240 IT'S SAD. 3838 02:45:14,240 --> 02:45:20,880 WELL WE SHOULD KNOW THIS. 3839 02:45:20,880 --> 02:45:26,400 IT'S TIME FOR A NEW GIES REPORT 3840 02:45:26,400 --> 02:45:27,560 THAT I WROTE IN 2009. 3841 02:45:27,560 --> 02:45:30,160 THE IMPORTANT POINT THAT 3842 02:45:30,160 --> 02:45:31,840 EXPERIMENTS CAN WORK. 3843 02:45:31,840 --> 02:45:33,280 THIS TALKS ABOUT A LOT OF 3844 02:45:33,280 --> 02:45:34,760 DIFFERENT KINDS OF PROGRAMS, ONE 3845 02:45:34,760 --> 02:45:36,760 OF THE MOST SUCCESSFUL, ARE 3846 02:45:36,760 --> 02:45:38,680 PREVIOUS SPEAKER IS A PRODUCT 3847 02:45:38,680 --> 02:45:38,880 OF. 3848 02:45:38,880 --> 02:45:40,760 THE Dr. MEDICAL SCIENCE 3849 02:45:40,760 --> 02:45:45,360 PROGRAM WHICH WAS INITIATED BY 3850 02:45:45,360 --> 02:45:47,640 PAUL GOLDAVER. 3851 02:45:47,640 --> 02:45:48,800 153 PEOPLE WENT INTO THAT 3852 02:45:48,800 --> 02:45:50,600 PROGRAM AND 93 STAYED IN FULL 3853 02:45:50,600 --> 02:45:53,440 TIME ACADEMICS AND RESEARCH. 3854 02:45:53,440 --> 02:45:54,280 AMAZING WORK. 3855 02:45:54,280 --> 02:45:55,720 I MEAN, THOSE ARE THE KINDS OF 3856 02:45:55,720 --> 02:46:00,600 THINGS THAT REALLY WORK AND IT'S 3857 02:46:00,600 --> 02:46:01,840 INTERESTING THAT OTHER PROGRAMS 3858 02:46:01,840 --> 02:46:12,360 IN THAT CATEGORY ORAL SCIENCE 3859 02:46:13,600 --> 02:46:16,120 PH.D THAT HAD A NIDCR TRAINING 3860 02:46:16,120 --> 02:46:17,720 GRANT AND WITH SEVERAL OTHER 3861 02:46:17,720 --> 02:46:18,720 WELL-KNOWN PEOPLE WENT THROUGH 3862 02:46:18,720 --> 02:46:21,040 THAT PROGRAM SO THE KINDS OF 3863 02:46:21,040 --> 02:46:23,240 THINGS THAT YOUR CONSIDERING 3864 02:46:23,240 --> 02:46:25,560 DOING, AS EXPERIMENTS IN PILOT 3865 02:46:25,560 --> 02:46:28,200 PROGRAMS ARE IMPORTANT. 3866 02:46:28,200 --> 02:46:30,120 AND THEY'RE RIGHT INTEGRATING 3867 02:46:30,120 --> 02:46:31,600 ORAL HEALTH IN GENERAL. 3868 02:46:31,600 --> 02:46:34,040 THE IMPORTANT THING AS RENA HAS 3869 02:46:34,040 --> 02:46:39,480 POINTED OUT, THAT A DENTAL 3870 02:46:39,480 --> 02:46:40,720 INSTITUTE CAME ABOUT BECAUSE OF 3871 02:46:40,720 --> 02:46:43,440 THE FAILURE OF PEOPLE TO BE 3872 02:46:43,440 --> 02:46:46,880 DRAFTED FOR WORLD WAR II AND WE 3873 02:46:46,880 --> 02:46:49,800 NEEDED SEVERAL MAN DAB YOU LAR 3874 02:46:49,800 --> 02:46:53,200 TEETH TO PULL A PIN ON A HAND 3875 02:46:53,200 --> 02:46:54,600 GRENADE IF YOU CAN'T DO THAT YOU 3876 02:46:54,600 --> 02:46:55,840 COULDN'T SERVE IN THE SERVICE. 3877 02:46:55,840 --> 02:47:06,400 IT'S COME A LONG WAY SINCE THEN. 3878 02:47:14,040 --> 02:47:15,280 THEY NEED TO STAY INVOLVED. 3879 02:47:15,280 --> 02:47:17,400 NEXT SLIDE, PLEASE. 3880 02:47:17,400 --> 02:47:17,960 THANK YOU. 3881 02:47:17,960 --> 02:47:19,880 SO HERE IS THE INTRODUCTION TO 3882 02:47:19,880 --> 02:47:21,280 ADVANCING DENTAL EDUCATION. 3883 02:47:21,280 --> 02:47:25,920 THIS WAS THE 21st CENTURY GIES 3884 02:47:25,920 --> 02:47:27,800 REPORT THAT LOOKED AT THE 3885 02:47:27,800 --> 02:47:31,560 PROFESSION IN GREAT DEPTH AND IN 3886 02:47:31,560 --> 02:47:33,280 DEED, THE PROBLEM IS THAT PEOPLE 3887 02:47:33,280 --> 02:47:35,640 DON'T WANT TO MAKE CHANGES. 3888 02:47:35,640 --> 02:47:38,800 WE INTRODUCED INTO PROFESSIONAL 3889 02:47:38,800 --> 02:47:39,280 EDUCATION. 3890 02:47:39,280 --> 02:47:41,440 WE TALK ABOUT A LOT OF THINGS 3891 02:47:41,440 --> 02:47:47,240 AND IN DEED, MOST OF DENTAL 3892 02:47:47,240 --> 02:47:48,240 EDUCATION IS ABOUT PROCEDURES 3893 02:47:48,240 --> 02:47:49,640 AND ON THE RIGHT WAS ATTEMPTED 3894 02:47:49,640 --> 02:47:51,160 WE MADE AT HARVARD TO INTRODUCE 3895 02:47:51,160 --> 02:47:55,040 AN INTEGRATED PRIMARY DENTAL 3896 02:47:55,040 --> 02:47:56,680 CARE SERVICES CLINIC WHICH HAS 3897 02:47:56,680 --> 02:47:58,240 WORKED OUT WITH NURSE 3898 02:47:58,240 --> 02:47:59,520 PRACTITIONERS VERY WELL AND HAS 3899 02:47:59,520 --> 02:48:03,200 BEEN A MODEL FOR OTHER PEOPLE TO 3900 02:48:03,200 --> 02:48:06,440 COPY. 3901 02:48:06,440 --> 02:48:09,000 NEXT, PLEASE. 3902 02:48:09,000 --> 02:48:13,040 MONTE MCNEIL AT UCONN MADE A 3903 02:48:13,040 --> 02:48:14,720 VERY GOOD CASE FOR INTEGRATED 3904 02:48:14,720 --> 02:48:16,840 ORAL AND PRIMARY MEDICAL 3905 02:48:16,840 --> 02:48:19,640 HEALTHCARE DELIVERY AND A FEW 3906 02:48:19,640 --> 02:48:21,320 YEARS AGO I WROTE WITH THE DEAN 3907 02:48:21,320 --> 02:48:22,760 OF MEDICAL SCHOOL THAT IT'S TIME 3908 02:48:22,760 --> 02:48:24,520 FOR THE INTEGRATION OF DENTAL 3909 02:48:24,520 --> 02:48:27,120 AND MEDICAL EDUCATION AND WE'RE 3910 02:48:27,120 --> 02:48:29,640 STILL AT THE POINT OF 3911 02:48:29,640 --> 02:48:30,920 NEGOTIATING THOSE CHANGES 3912 02:48:30,920 --> 02:48:33,120 BECAUSE YOU KNOW WHAT GOT IN THE 3913 02:48:33,120 --> 02:48:34,040 WAY OF PANDEMIC. 3914 02:48:34,040 --> 02:48:38,800 THE NEXT PLEASE. 3915 02:48:38,800 --> 02:48:40,880 HERE IS THE PAPER THAT ORAL 3916 02:48:40,880 --> 02:48:43,000 HEALTH FOR ALL REALIZING THE 3917 02:48:43,000 --> 02:48:46,080 PROMISE OF SCIENCE AND IT REALLY 3918 02:48:46,080 --> 02:48:47,200 IS WELL WRITTEN BUT ON THE RIGHT 3919 02:48:47,200 --> 02:48:49,200 IS A PIECE FROM THE SCIENCE 3920 02:48:49,200 --> 02:48:52,640 TIMES TUESDAY IN THE "NEW YORK 3921 02:48:52,640 --> 02:48:54,400 TIMES" BEHIND HEALTH ROBBING 3922 02:48:54,400 --> 02:48:56,080 AILMENTS, INFLAMMATION AND GUESS 3923 02:48:56,080 --> 02:49:02,720 WHAT IS NOT MENTIONED AT ALL -- 3924 02:49:02,720 --> 02:49:06,240 PERPERIODONTAL DISEASE. 3925 02:49:06,240 --> 02:49:09,400 WE HAVE A LOT OF WORK TO DO. 3926 02:49:09,400 --> 02:49:13,960 WE CAN'T JUST TALK TO OURSELVES. 3927 02:49:13,960 --> 02:49:15,840 THERE HAVE BEEN SEVERAL 3928 02:49:15,840 --> 02:49:18,800 RECOMMENDATIONS FOR REVIEW OF 3929 02:49:18,800 --> 02:49:21,120 INSTITUTIONS THAT HAVE DONE 3930 02:49:21,120 --> 02:49:24,600 MEDICAL INTEGRATION, KAISER 3931 02:49:24,600 --> 02:49:26,840 PERMANENTE, HEALTH PARTNERS IN 3932 02:49:26,840 --> 02:49:28,600 MINNESOTA. 3933 02:49:28,600 --> 02:49:30,080 GREATER 'EM PHYSICIAN SHOULD BE 3934 02:49:30,080 --> 02:49:31,440 PLACED ON FOUNDATIONAL AND 3935 02:49:31,440 --> 02:49:32,960 APPLIED MEDICAL EDUCATION WITHIN 3936 02:49:32,960 --> 02:49:34,720 THE DENTAL CURRICULUM. 3937 02:49:34,720 --> 02:49:36,480 DENTAL SCHOOLS AND OTHER DENTAL 3938 02:49:36,480 --> 02:49:37,920 EDUCATION INSTITUTIONS SHOULD 3939 02:49:37,920 --> 02:49:40,400 PURSUE AN INTEGRATED 3940 02:49:40,400 --> 02:49:41,160 MULTI-DISCIPLINARY APPROACH IN 3941 02:49:41,160 --> 02:49:43,960 THE OVER ALL CURRICULUM AND 3942 02:49:43,960 --> 02:49:45,160 DENTAL GRADUATES SHOULD BE MORE 3943 02:49:45,160 --> 02:49:48,360 KILLED AND USING HEALTH ANALYTIC 3944 02:49:48,360 --> 02:49:50,480 TOOLS AND IN THE INTERPRETATION 3945 02:49:50,480 --> 02:49:53,040 OF SUMMARY INFORMATION FROM THE 3946 02:49:53,040 --> 02:49:55,320 LARGE SETS OF HEALTHCARE DATA 3947 02:49:55,320 --> 02:49:58,920 AVAILABLE AND THEY'VE TALKED 3948 02:49:58,920 --> 02:50:09,000 ABOUT THAT. 3949 02:50:09,000 --> 02:50:10,320 DENTAL EDUCATION MUST MAKE A 3950 02:50:10,320 --> 02:50:12,560 BOLD MOVE TO ACQUIRE HEALTH 3951 02:50:12,560 --> 02:50:13,080 RECOMMENDATIONS WHICH IS 3952 02:50:13,080 --> 02:50:14,120 IMPORTANT AND CHANGING THE 3953 02:50:14,120 --> 02:50:16,000 CULTURAL AND THE PROFESSION IS 3954 02:50:16,000 --> 02:50:24,880 MUCH MORE IMPORTANT SO, I USED 3955 02:50:24,880 --> 02:50:28,080 TO, WHEN WE HAVE THESE THINGS 3956 02:50:28,080 --> 02:50:30,120 HERE, HOW DO WE OPT FOR CHANGE? 3957 02:50:30,120 --> 02:50:32,680 WE CAN CHANGE THE PRACTICE ACTS 3958 02:50:32,680 --> 02:50:36,360 IN THE FACE OF POLITICS, VERY 3959 02:50:36,360 --> 02:50:36,640 DIFFICULT. 3960 02:50:36,640 --> 02:50:39,200 WE CAN ADD IPE PRACTICE AND 3961 02:50:39,200 --> 02:50:41,600 NURSE PRACTITIONERS AND WE CAN 3962 02:50:41,600 --> 02:50:45,320 CHANGE DENTAL EDUCATION. 3963 02:50:45,320 --> 02:50:47,120 IT'S NOT AN EASY TASK. 3964 02:50:47,120 --> 02:50:49,760 BUT I LIKE THE IDEA OF A 3965 02:50:49,760 --> 02:50:51,960 DUEL-DEGREE AND RESIDENCY THAT 3966 02:50:51,960 --> 02:50:54,800 WOULD MAKE SOMEONE THE 3967 02:50:54,800 --> 02:50:58,680 EQUIVALENT OF ANYONE ELSE IN 3968 02:50:58,680 --> 02:51:01,480 HEALTHCARE SO THAT YOU COULD 3969 02:51:01,480 --> 02:51:03,400 REALLY DEVELOP CHAMPIONS FOR 3970 02:51:03,400 --> 02:51:05,040 PUTTING THE MOUTH BACK IN THE 3971 02:51:05,040 --> 02:51:06,520 BODY AND YOU DON'T NEED A 3972 02:51:06,520 --> 02:51:09,360 THOUSAND OF THESE PEOPLE. 3973 02:51:09,360 --> 02:51:11,640 YOU YOU DON'T NEED 15000 OF 3974 02:51:11,640 --> 02:51:14,040 THESE PEOPLE BUT MAYBE 50 TO 100 3975 02:51:14,040 --> 02:51:15,640 COULD CHANGE THE SCENE AND IN 3976 02:51:15,640 --> 02:51:18,480 FACT, ALTHOUGH THE ORIGINAL 3977 02:51:18,480 --> 02:51:20,720 PLANS WAS FOR DENTAL SCHOOL TO 3978 02:51:20,720 --> 02:51:22,040 MEDICAL SCHOOL IS PART OF THIS 3979 02:51:22,040 --> 02:51:24,680 KIND OF TRAINING, FOLLOWED BY 3980 02:51:24,680 --> 02:51:27,280 APPROPRIATE RESIDENCY, YOU WOULD 3981 02:51:27,280 --> 02:51:31,920 HAVE TWO OPPORTUNITIES NOW FOR 3982 02:51:31,920 --> 02:51:34,320 MEDICAL SCHOOLS STUDENTS TO COME 3983 02:51:34,320 --> 02:51:36,080 THOUGH DENTAL SCHOOLS WITH 3984 02:51:36,080 --> 02:51:39,240 ADVANCED STANDINGS AND IT'S AN 3985 02:51:39,240 --> 02:51:41,200 INTERESTING WAY TO DO IT AND 3986 02:51:41,200 --> 02:51:45,880 ALTHOUGH WORKING WITH TWO VERY 3987 02:51:45,880 --> 02:51:46,800 FINE MEDICAL SCHOOLS THAT DON'T 3988 02:51:46,800 --> 02:51:49,280 HAVE DENTAL SCHOOLS TO TRY AND 3989 02:51:49,280 --> 02:51:50,920 ACCOMPLISH IT AND IN FACT, THE 3990 02:51:50,920 --> 02:51:52,200 WHOLE IDEA OF WHAT YOU'VE DONE 3991 02:51:52,200 --> 02:51:56,960 HERE IN TRANSFORMING THE PBRN IS 3992 02:51:56,960 --> 02:51:58,280 VERY EXCITE TO ME. 3993 02:51:58,280 --> 02:52:00,400 I HAVEN'T HAD A WHOLE HOST OF 3994 02:52:00,400 --> 02:52:03,560 TIME TO LOOK AT THIS BY THINK 3995 02:52:03,560 --> 02:52:06,840 ALTHOUGH IT WAS MEANT TO MOVE 3996 02:52:06,840 --> 02:52:10,000 PVRNs AND RESEARCH OUT OF THE 3997 02:52:10,000 --> 02:52:11,800 PRIVATE OFFICE, EVEN UNDER THE 3998 02:52:11,800 --> 02:52:15,840 INFLUENCE OF DENTAL SERVICE 3999 02:52:15,840 --> 02:52:24,040 ORGANIZATIONS, DO YOU THIS IN 4000 02:52:24,040 --> 02:52:25,560 DENTAL SCHOOLS AND HOSPITALS SO 4001 02:52:25,560 --> 02:52:26,760 THAT STUDENTS WORKED WITH OTHER 4002 02:52:26,760 --> 02:52:28,560 MEMBERS OF THE HEALTH 4003 02:52:28,560 --> 02:52:34,120 PROFESSIONAL AND I THINK SINCE 4004 02:52:34,120 --> 02:52:36,000 THIS IS COME OUT AND ME READING 4005 02:52:36,000 --> 02:52:40,560 IT I THINK IT'S A REAL 4006 02:52:40,560 --> 02:52:40,840 POSSIBILITY. 4007 02:52:40,840 --> 02:52:42,560 SOMEONE JUST ASKED ABOUT GPRs 4008 02:52:42,560 --> 02:52:44,200 AND I SERVED FOR SEVEN YEARS 4009 02:52:44,200 --> 02:52:47,040 WITH ALAN FORMER COLA ON A 4010 02:52:47,040 --> 02:52:51,400 COMMITTEE TO MAKE GPRs MORE 4011 02:52:51,400 --> 02:53:01,920 IMPORTANT AND IN FACT, AND HE 4012 02:53:46,520 --> 02:53:49,040 USED TO SAY, WHEN I WANT TO GET 4013 02:53:49,040 --> 02:53:54,840 A PRESENT FOR SOMEONE, I WOULD 4014 02:53:54,840 --> 02:53:55,560 GO TO BEST BUY. 4015 02:53:55,560 --> 02:53:57,360 IF I WANTED TO GET SOMETHING TO 4016 02:53:57,360 --> 02:53:59,640 FIX SOMETHING AROUND MY HOUSE, I 4017 02:53:59,640 --> 02:54:02,640 WOULD GO TO HOME DEPOT BUT THEN 4018 02:54:02,640 --> 02:54:06,320 I COULD GO TO ONE STORE, 4019 02:54:06,320 --> 02:54:08,080 WAL-MART AND IF I NEEDED 4020 02:54:08,080 --> 02:54:11,360 GASOLINE, I WOULD GO TO AN ESSO 4021 02:54:11,360 --> 02:54:12,080 GAS STATION. 4022 02:54:12,080 --> 02:54:14,480 IF I NEEDED A SNACK I WENT TO A 4023 02:54:14,480 --> 02:54:16,840 711 BUT THEN I COULD GO TO AN 4024 02:54:16,840 --> 02:54:18,880 INTEGRATED GAS STATION SNACK 4025 02:54:18,880 --> 02:54:20,200 PLACE AND TO ACCOMPLISH THIS AND 4026 02:54:20,200 --> 02:54:23,040 HE WAS A GREAT FAN OF THE IDEA 4027 02:54:23,040 --> 02:54:28,280 OF INTEGRATED PRACTICE. 4028 02:54:28,280 --> 02:54:29,240 NEXT, PLEASE. 4029 02:54:29,240 --> 02:54:30,880 SO, THERE HAVE BEEN LOTS OF 4030 02:54:30,880 --> 02:54:32,600 MAJOR REPORTS. 4031 02:54:32,600 --> 02:54:34,080 WE HAVE ENOUGH REPORTS TO LAST 4032 02:54:34,080 --> 02:54:35,680 US A LIFETIME. 4033 02:54:35,680 --> 02:54:37,760 THE IOM REPORT, THE FIRST 4034 02:54:37,760 --> 02:54:39,920 SURGEON GENERAL'S REPORT AND 4035 02:54:39,920 --> 02:54:41,200 IDEAS, EFFORTS AND INTER 4036 02:54:41,200 --> 02:54:43,520 PROFESSIONAL ALLIANCE AND THE 4037 02:54:43,520 --> 02:54:45,800 21st CENTURY GEIS REPORT, THE 4038 02:54:45,800 --> 02:54:47,360 DENTIST SCIENTIST WORKFORCE 4039 02:54:47,360 --> 02:54:49,760 ISSUE AND THE 2020 SURGEON 4040 02:54:49,760 --> 02:54:51,760 GENERAL'S REPORT ON ORAL HEALTH, 4041 02:54:51,760 --> 02:54:56,280 WHICH WE ALL KNOW ABOUT, THE 4042 02:54:56,280 --> 02:55:03,520 NEXT, PLEASE. 4043 02:55:03,520 --> 02:55:12,160 THE NEXT. 4044 02:55:12,160 --> 02:55:14,440 I PUT HIM TO SLEEP. 4045 02:55:14,440 --> 02:55:14,840 [LAUGHTER] 4046 02:55:14,840 --> 02:55:16,640 >> DON'T LET A CRISIS GO TO 4047 02:55:16,640 --> 02:55:19,840 WASTE AND WE CERTAINLY HAD A 4048 02:55:19,840 --> 02:55:20,080 CRISIS. 4049 02:55:20,080 --> 02:55:21,760 THE PANDEMIC, MANY SMARTER 4050 02:55:21,760 --> 02:55:23,400 PEOPLE THAN I HAVE WRITTEN ABOUT 4051 02:55:23,400 --> 02:55:28,560 WHAT IT'S DONE TO HEALTHCARE AND 4052 02:55:28,560 --> 02:55:29,480 ECONOMICS PUBLIC-HEALTH BUT WHAT 4053 02:55:29,480 --> 02:55:31,880 I REMEMBER IN THE EARLY 1990s, 4054 02:55:31,880 --> 02:55:35,200 WHEN I WAS STILL CHIEF OF ORAL 4055 02:55:35,200 --> 02:55:36,640 AND FACIAL SURGERY AT THE MASS 4056 02:55:36,640 --> 02:55:38,960 GENERAL HOSPITAL, I HEARD FOR 4057 02:55:38,960 --> 02:55:41,360 THE FIRST TIME, THE TERM 4058 02:55:41,360 --> 02:55:44,080 "COVERED LIVES." 4059 02:55:44,080 --> 02:55:46,440 NOT PATIENTS. 4060 02:55:46,440 --> 02:55:48,800 AND AT THE SAME TIME, WE STOPPED 4061 02:55:48,800 --> 02:55:50,480 CALLING PEOPLE DOCTORS AND BEGAN 4062 02:55:50,480 --> 02:55:53,400 TO CALL THEM PROVIDERS. 4063 02:55:53,400 --> 02:55:54,720 WELL, COVERED LIVES AND 4064 02:55:54,720 --> 02:55:57,640 PROVIDERS HAVE DOMINATED HEALTH 4065 02:55:57,640 --> 02:56:02,040 CARE DELIVERY SINCE THAT TIME. 4066 02:56:02,040 --> 02:56:03,400 THEODORE ROSE BERRY AND THE 4067 02:56:03,400 --> 02:56:05,840 30th ANNIVERSARY OF THE GEIS 4068 02:56:05,840 --> 02:56:08,560 REPORT IN 1955, BELIEVE IF OR 4069 02:56:08,560 --> 02:56:09,640 NOT, MADE AN INTERESTING 4070 02:56:09,640 --> 02:56:16,400 STATEMENT THAT UP UNTIL THAT 4071 02:56:16,400 --> 02:56:19,360 TIME, DENTISTRY HAD BIG WINS 4072 02:56:19,360 --> 02:56:23,440 I.E. FLUORIDE BUT THEY HAD NOT 4073 02:56:23,440 --> 02:56:24,800 DEVELOPED ANY MEDICAL TREATMENTS 4074 02:56:24,800 --> 02:56:26,520 OF DISEASE THAT COULDN'T RAID 4075 02:56:26,520 --> 02:56:28,040 INDICATE DISEASE AND THAT'S WHAT 4076 02:56:28,040 --> 02:56:29,800 WE STILL NEED TO DO AND MEDICINE 4077 02:56:29,800 --> 02:56:33,720 HAS BEEN ABLE TO DO IT AND 4078 02:56:33,720 --> 02:56:38,320 THAT'S WHY SCIENCE IS MUCH MORE 4079 02:56:38,320 --> 02:56:40,440 APART OF MEDICINE THAN IT IS 4080 02:56:40,440 --> 02:56:45,440 DENTISTRY UNFORTUNATELY. 4081 02:56:45,440 --> 02:56:49,080 HE WAS A SCIENCE ADVISER AND SET 4082 02:56:49,080 --> 02:56:51,120 STAGE FOR THE NIH, REALLY 4083 02:56:51,120 --> 02:56:56,760 BELIEVED IN SCIENCE AND VIETNAM 4084 02:56:56,760 --> 02:56:58,640 WAR, FOR THOSE AT MY AGE, 4085 02:56:58,640 --> 02:57:00,160 REMEMBERS THE YELLOW BERETS THAT 4086 02:57:00,160 --> 02:57:02,400 WENT TO THE NIH AND BECAME 4087 02:57:02,400 --> 02:57:03,440 OUTSTANDING SCIENTISTS AND 4088 02:57:03,440 --> 02:57:04,760 THAT'S WHAT YOU ARE TRYING TO DO 4089 02:57:04,760 --> 02:57:06,640 AGAIN AND THEN I ALSO REMEMBER 4090 02:57:06,640 --> 02:57:08,000 CHANGE IS POSSIBLE. 4091 02:57:08,000 --> 02:57:09,840 THE NATIONAL INSTITUTES FOR 4092 02:57:09,840 --> 02:57:12,920 DENTAL RESEARCH BECAME THE NEXT 4093 02:57:12,920 --> 02:57:15,400 INSTITUTES OF DENTAL AND CRANIAL 4094 02:57:15,400 --> 02:57:18,480 FACIAL RESEARCH UNDER Dr. 4095 02:57:18,480 --> 02:57:20,840 SLAVKA SO THE ALLIANCE BETWEEN 4096 02:57:20,840 --> 02:57:24,080 MEDICINE AND DENTISTRY IS 4097 02:57:24,080 --> 02:57:25,120 IMPORTANT AND SIGNALS A 4098 02:57:25,120 --> 02:57:26,200 COMMITMENT TO SCIENCE AND I DO 4099 02:57:26,200 --> 02:57:29,040 NOT THINK THE STATUS QUO IS 4100 02:57:29,040 --> 02:57:31,400 INEVITABLE AND I THINK EDUCATION 4101 02:57:31,400 --> 02:57:34,000 AND RESEARCH CAN DRIVE THE 4102 02:57:34,000 --> 02:57:35,680 PROFESSION AND THAT IS AN 4103 02:57:35,680 --> 02:57:41,400 IMPORTANT ROLE FOR THE NIH AND 4104 02:57:41,400 --> 02:57:41,680 THE NIDCR. 4105 02:57:41,680 --> 02:57:50,040 NEXT SLIDE. 4106 02:57:50,040 --> 02:57:53,040 NEXT, PLEASE. 4107 02:57:53,040 --> 02:57:56,680 SO, THERE ARE A LOT OF REPORTS 4108 02:57:56,680 --> 02:57:59,400 ON MEDICAL INTEGRATION. 4109 02:57:59,400 --> 02:58:04,320 I WROTE THIS IN 1993. 4110 02:58:04,320 --> 02:58:07,760 STAKEHOLDERS WHO ARE INTERESTED 4111 02:58:07,760 --> 02:58:09,640 IN THIS. 4112 02:58:09,640 --> 02:58:14,480 LA CASCADA TALKING ABOUT MEDICAL 4113 02:58:14,480 --> 02:58:16,440 DENTAL AND EDUCATION AND WE'VE 4114 02:58:16,440 --> 02:58:18,120 STARTED THE HARVARD INITIATIVE 4115 02:58:18,120 --> 02:58:22,560 FOR INTEGRATION AND CIPCOH, 4116 02:58:22,560 --> 02:58:23,040 CENTER FOR INCOMPETENT 4117 02:58:23,040 --> 02:58:24,200 INAUGURATION OF PRIMARY CARE AND 4118 02:58:24,200 --> 02:58:27,040 IN FACT, UNDER THIS THE FIRST 4119 02:58:27,040 --> 02:58:29,040 DENTAL RESIDENCY IN NEW 4120 02:58:29,040 --> 02:58:31,400 HAMPSHIRE HAS BEEN APPROVED AND 4121 02:58:31,400 --> 02:58:33,040 WILL START VERY SOON. 4122 02:58:33,040 --> 02:58:34,320 CAN YOU IMAGINE THAT? 4123 02:58:34,320 --> 02:58:37,000 NO DENTAL RESIDENCIES IN RURAL 4124 02:58:37,000 --> 02:58:37,760 NEW HAMPSHIRE. 4125 02:58:37,760 --> 02:58:39,640 SO THE QUESTION IS, HOW DO WE 4126 02:58:39,640 --> 02:58:41,920 CREATE LEADERS THAT FALLS BACK 4127 02:58:41,920 --> 02:58:45,080 TO THE PROGRAM THAT DANA GRAVES 4128 02:58:45,080 --> 02:58:46,800 IS RUNNING AND I'M HAPPY TO BE 4129 02:58:46,800 --> 02:58:47,960 PART OF IT. 4130 02:58:47,960 --> 02:58:50,320 WE NEED MENTORS, WE NEED 4131 02:58:50,320 --> 02:58:51,960 HEAR-OUT PROGRAMS AND WE NEED TO 4132 02:58:51,960 --> 02:58:53,240 CHANGE THE CULTURE. 4133 02:58:53,240 --> 02:58:58,760 THE NEXT, PLEASE. 4134 02:58:58,760 --> 02:59:01,080 SO, WE NEED TO CREATE CAT A LID 4135 02:59:01,080 --> 02:59:03,720 I CAN MECHANISMS FOR CHANGE. 4136 02:59:03,720 --> 02:59:07,480 DUEL-DEGREE PROGRAMS AND PRIMARY 4137 02:59:07,480 --> 02:59:16,000 CARE AND IT WAS DESIGNED TO 4138 02:59:16,000 --> 02:59:17,880 PERMIT SURGICAL TRAINING AT AN 4139 02:59:17,880 --> 02:59:19,800 APPROPRIATE LEVEL OF 4140 02:59:19,800 --> 02:59:20,160 RESPONSIBILITY. 4141 02:59:20,160 --> 02:59:22,160 WHICH IS ENABLED BY THE MD. 4142 02:59:22,160 --> 02:59:24,560 AND THAT IS WHAT THIS 4143 02:59:24,560 --> 02:59:26,280 EDUCATIONAL PROGRAM IS ABOUT. 4144 02:59:26,280 --> 02:59:28,120 MAKE ORAL HEALTH PART OF OVER 4145 02:59:28,120 --> 02:59:31,320 ALL HEALTH AND IN PRACTICE AND 4146 02:59:31,320 --> 02:59:33,680 RESEARCH AND SAVE THE ENDANGERED 4147 02:59:33,680 --> 02:59:35,680 DENTIST SCIENTISTS, I REALLY 4148 02:59:35,680 --> 02:59:40,240 THINK IT'S POSSIBLE. 4149 02:59:40,240 --> 02:59:41,760 OTHER IMPORTANT ISSUES. 4150 02:59:41,760 --> 02:59:49,840 IT'S BEEN TAKEN ON BY THE WORLD 4151 02:59:49,840 --> 02:59:53,320 BUT WE HAVE TO DEAL WITH THE 4152 02:59:53,320 --> 02:59:53,640 UNITED STATES. 4153 02:59:53,640 --> 02:59:57,000 IT'S VERY IMPORTANT AND WE SEE 4154 02:59:57,000 --> 02:59:58,760 BUSINESS PLAYING THIS GAME. 4155 02:59:58,760 --> 03:00:01,000 AMAZON BUYING ONE MEDICAL AND 4156 03:00:01,000 --> 03:00:03,000 LAST BUT NOT LEAST, WHAT THE 4157 03:00:03,000 --> 03:00:05,560 PANDEMIC HAS DONE WITH THE LOSS, 4158 03:00:05,560 --> 03:00:07,040 VACANTED BUDGETED FACULTY 4159 03:00:07,040 --> 03:00:08,480 POSITIONS IN U.S. DENTAL. 4160 03:00:08,480 --> 03:00:09,680 IT'S INCREDIBLE. 4161 03:00:09,680 --> 03:00:11,080 WHO IS GOING TO TEACH? 4162 03:00:11,080 --> 03:00:17,680 WHO IS GOING TO TEACH THE NEXT 4163 03:00:17,680 --> 03:00:17,920 PLEASE. 4164 03:00:17,920 --> 03:00:19,960 SO, HERE IS DENTAL EDUCATION 4165 03:00:19,960 --> 03:00:21,160 CROSS ROADS INSTITUTE OF 4166 03:00:21,160 --> 03:00:24,520 MEDICINE AND 1995. 4167 03:00:24,520 --> 03:00:30,440 IF YOU HAVE A CHANCE, READ IT. 4168 03:00:30,440 --> 03:00:34,440 GIES REPORT, GOOD REPORT, READ 4169 03:00:34,440 --> 03:00:35,080 IT. 4170 03:00:35,080 --> 03:00:36,960 INNOVATORS DILEMMA, GREAT BOOK. 4171 03:00:36,960 --> 03:00:39,000 READ IT. 4172 03:00:39,000 --> 03:00:40,960 BLUE OCEAN STRATEGY. 4173 03:00:40,960 --> 03:00:42,400 AN INTERESTING BOOK AND TALKS 4174 03:00:42,400 --> 03:00:44,560 ABOUT DIFFERENT WAYS OF THINKING 4175 03:00:44,560 --> 03:00:49,520 ABOUT IT AND JUST CONSIDER THIS, 4176 03:00:49,520 --> 03:00:52,160 WRING LING BROTHERS BAR LEM AND 4177 03:00:52,160 --> 03:00:54,320 BAILEY CIRCUS NO LONGER EXISTS 4178 03:00:54,320 --> 03:00:55,880 BUT CIRQUE DU SOLEIL IS THRIVING 4179 03:00:55,880 --> 03:00:58,440 SO CHANGE IS POSSIBLE. 4180 03:00:58,440 --> 03:01:00,640 MOST OF ALL, THE MOST INNOVATIVE 4181 03:01:00,640 --> 03:01:08,000 THING, EVER, IS AN OREO PACKAGE 4182 03:01:08,000 --> 03:01:14,120 THAT CAN YOU OPEN BY RIPPING THE 4183 03:01:14,120 --> 03:01:14,360 FLAP UP. 4184 03:01:14,360 --> 03:01:16,520 >> I REALLY BELIEVE IN THIS AND 4185 03:01:16,520 --> 03:01:19,880 THE KEY TO REFORM OF ALMOST ANY 4186 03:01:19,880 --> 03:01:21,520 KIND OF HIGHER TED INDICATION 4187 03:01:21,520 --> 03:01:22,800 LIES NOT IN THE WAY THAT 4188 03:01:22,800 --> 03:01:24,480 KNOWLEDGE IS PRODUCED, IT LIES 4189 03:01:24,480 --> 03:01:29,000 IN THE WAY THAT THE PRODUCERS OF 4190 03:01:29,000 --> 03:01:30,560 KNOWLEDGE ARE PRODUCED FROM THE 4191 03:01:30,560 --> 03:01:34,560 MARKETPLACE OF IDEAS AND BY 4192 03:01:34,560 --> 03:01:37,440 LOUIS MENARD WHO TEACHES AT 4193 03:01:37,440 --> 03:01:37,640 HARVARD. 4194 03:01:37,640 --> 03:01:38,960 IF YOU HAVEN'T READ IT, THIS IS 4195 03:01:38,960 --> 03:01:41,360 A RECENT AUGUST EDITORIAL IN THE 4196 03:01:41,360 --> 03:01:44,280 JOURNAL OF THE AMERICAN DENTAL 4197 03:01:44,280 --> 03:01:46,040 ASSOCIATION AND BY MYSELF AND 4198 03:01:46,040 --> 03:01:51,520 THE FUTURE LEASE ASSIGNMENT AND 4199 03:01:51,520 --> 03:01:53,440 WHAT NEEDS TO HAPPEN IN DENTAL 4200 03:01:53,440 --> 03:01:53,720 EDUCATION. 4201 03:01:53,720 --> 03:01:55,200 THANK YOU VERY MUCH AND I'M 4202 03:01:55,200 --> 03:02:00,360 HAPPY TO ANSWER ANY QUESTIONS. 4203 03:02:00,360 --> 03:02:09,920 >> ARE THERE ANY QUESTIONS. 4204 03:02:09,920 --> 03:02:10,560 OR COMMENTS? 4205 03:02:10,560 --> 03:02:15,360 >> IT'S TERRY DICK INSON. 4206 03:02:15,360 --> 03:02:25,440 SO MANY THINGS YOU SAID -- I 4207 03:02:25,440 --> 03:02:27,720 KNOW OF ONE SPOT HEALTH-CARE 4208 03:02:27,720 --> 03:02:29,400 SYSTEM IN VIRGINIA AND THEY'VE 4209 03:02:29,400 --> 03:02:30,840 DONE THIS FOR A NUMBER OF YEARS 4210 03:02:30,840 --> 03:02:32,760 AND THEY HAD A CHAMPION WHICH 4211 03:02:32,760 --> 03:02:35,040 YOU SPEAK TO AND THAT'S WHAT YOU 4212 03:02:35,040 --> 03:02:35,280 NEED. 4213 03:02:35,280 --> 03:02:39,040 THEY'VE REALLY INTEGRATED DENTAL 4214 03:02:39,040 --> 03:02:42,240 INTO THE MEDICAL SCHOOL THERE 4215 03:02:42,240 --> 03:02:43,440 AND SO YOU ARE RIGHT, THERE'S 4216 03:02:43,440 --> 03:02:46,040 NOT MANY OF THEM OUT THERE BUT 4217 03:02:46,040 --> 03:02:47,960 THERE ARE SOME OUT THERE BUT IT 4218 03:02:47,960 --> 03:02:49,680 DEPENDS SO MUCH ON THAT CHAMPION 4219 03:02:49,680 --> 03:02:52,440 THAT IS WILLING TO PUT THE TIME 4220 03:02:52,440 --> 03:02:55,080 AND ENERGY AND HEART INTO 4221 03:02:55,080 --> 03:02:58,520 GETTING THAT THING TO WORK. 4222 03:02:58,520 --> 03:02:59,600 WE JUST HAVE TO KEEP TRYING. 4223 03:02:59,600 --> 03:03:01,920 >> THIS IS A GREAT PROGRAM. 4224 03:03:01,920 --> 03:03:02,640 >> THANK YOU. 4225 03:03:02,640 --> 03:03:06,120 >> AND THEN I WOULD SAY ALSO, 4226 03:03:06,120 --> 03:03:07,920 BRUCE, THAT IF YOU REMEMBER THE 4227 03:03:07,920 --> 03:03:11,600 DAYS WHEN MARGI, GOD BLESS HER 4228 03:03:11,600 --> 03:03:13,480 SOUL, RAN THOSE STUDIES WHERE 4229 03:03:13,480 --> 03:03:15,520 SHE COMPARED IT WAS DELTA DENTAL 4230 03:03:15,520 --> 03:03:17,640 AND ANOTHER COHORT OF RECORDS 4231 03:03:17,640 --> 03:03:19,640 SHE LOCKED AT TO SHOW THAT IF 4232 03:03:19,640 --> 03:03:22,880 YOU ACTUALLY TREATED GUM DISEASE 4233 03:03:22,880 --> 03:03:30,120 OR PRAIR PERRY TONIGHTAL DISEASU 4234 03:03:30,120 --> 03:03:40,760 WERE ABLE TO -- ALLOWS US TO CRE 4235 03:03:43,200 --> 03:03:44,840 THE EVIDENCE THAT THAT 4236 03:03:44,840 --> 03:03:46,240 INTEGRATION IS NECESSARY, RIGHT. 4237 03:03:46,240 --> 03:03:49,920 SO I SEE ANOTHER ADVANTAGE TO 4238 03:03:49,920 --> 03:03:51,360 TRAINING INDIVIDUALS AND PORT 4239 03:03:51,360 --> 03:03:53,400 LEADERS AND WHO WOULD SAY I'VE 4240 03:03:53,400 --> 03:03:54,920 GOT THIS WHOLE PATIENT AND I'M 4241 03:03:54,920 --> 03:03:56,240 LOOKING AT EVERYTHING FROM 4242 03:03:56,240 --> 03:03:57,280 HEAD-TO-TOE AND NOT CUTTING THE 4243 03:03:57,280 --> 03:04:02,960 HEAD AND HAVING IT FLOAT IN 4244 03:04:02,960 --> 03:04:05,120 SPACE BECAUSE VISION AND HEARING 4245 03:04:05,120 --> 03:04:07,600 IS ALSO LOST IN SPACE SO YEAH, I 4246 03:04:07,600 --> 03:04:10,240 SO AM HOPING THAT DAN A. I 4247 03:04:10,240 --> 03:04:12,800 ENCOURAGE DANA'S GROUP TO LOOK 4248 03:04:12,800 --> 03:04:14,960 AT THIS MODEL AS A TESTING 4249 03:04:14,960 --> 03:04:17,200 SYSTEM PERHAPS THAT WE CAN 4250 03:04:17,200 --> 03:04:23,840 CONSIDER OUR LAUNCH INTO. 4251 03:04:23,840 --> 03:04:30,000 >> THANK YOU FOR ASKING ME TO 4252 03:04:30,000 --> 03:04:30,200 SPEAK. 4253 03:04:30,200 --> 03:04:33,200 >> Lynn M. King: THANK YOU Dr. 4254 03:04:33,200 --> 03:04:33,440 DONOFF. 4255 03:04:33,440 --> 03:04:36,280 >> SO, THIS IS JACK FROM 4256 03:04:36,280 --> 03:04:38,680 UNIVERSITY OF MICHIGAN AND 4257 03:04:38,680 --> 03:04:42,000 EXCELLENT PRESENTATION Dr. 4258 03:04:42,000 --> 03:04:42,240 DONOFF. 4259 03:04:42,240 --> 03:04:43,160 I WAS INTRIGUED WHEN YOU WERE 4260 03:04:43,160 --> 03:04:46,400 TALKING ABOUT THE REVIEW FROM 4261 03:04:46,400 --> 03:04:48,040 KAISER PERMANENTE ABOUT GOING 4262 03:04:48,040 --> 03:04:49,960 BEYOND TRADITIONAL IPE PROGRAMS 4263 03:04:49,960 --> 03:04:51,800 AND CAN YOU EXPAND A LITTLE BIT 4264 03:04:51,800 --> 03:04:53,960 MORE ON THAT? 4265 03:04:53,960 --> 03:04:59,240 >> WELL, I HAVE NOT VISITED OUT 4266 03:04:59,240 --> 03:05:02,560 THERE FOR ABOUT THREE YEARS BUT 4267 03:05:02,560 --> 03:05:05,200 THEY HAD CLINICS WHERE THEY 4268 03:05:05,200 --> 03:05:06,360 ACTUALLY DID THIS. 4269 03:05:06,360 --> 03:05:11,040 THEY HAD PHYSICIANS AND NURSE 4270 03:05:11,040 --> 03:05:11,680 PRACTITIONERS WORKING TOGETHER 4271 03:05:11,680 --> 03:05:14,480 AND OF COURSE, NOW, KAISER HAS 4272 03:05:14,480 --> 03:05:18,120 THEIR OWN MEDICAL SCHOOL IN 4273 03:05:18,120 --> 03:05:20,560 PASADENA AND SINCE I KNEW THE 4274 03:05:20,560 --> 03:05:21,760 DEAN AT CHILDREN'S HOSPITAL IN 4275 03:05:21,760 --> 03:05:23,880 BOSTON I TRIED TO GET TO FORM A 4276 03:05:23,880 --> 03:05:26,040 DENTAL SCHOOL BUT HE RAN OUT OF 4277 03:05:26,040 --> 03:05:28,320 MONEY AND IN ANY CASE, YEAH, I 4278 03:05:28,320 --> 03:05:30,560 THINK THIS CAN WORK. 4279 03:05:30,560 --> 03:05:34,840 YOU DON'T HAVE TO BE THE DENTIST 4280 03:05:34,840 --> 03:05:37,680 WHO IS GOING TO DO EVERY 4281 03:05:37,680 --> 03:05:37,920 PROCEDURE. 4282 03:05:37,920 --> 03:05:41,920 BUT YOU CERTAINLY NEED TO BE 4283 03:05:41,920 --> 03:05:45,560 SOMEONE WHO LISTENING TO THE 4284 03:05:45,560 --> 03:05:47,320 CONVERSATIONS ABOUT OR ALKAN SER 4285 03:05:47,320 --> 03:05:52,400 DETECTION TODAY, YOU KNOW, THE 4286 03:05:52,400 --> 03:05:54,760 LEADING CAUSE FOR SUITES AGAINST 4287 03:05:54,760 --> 03:05:57,440 DENTIST IS NATIONALLY, FAILURE 4288 03:05:57,440 --> 03:05:59,440 TO DETECT THE OR ALKAN SER 4289 03:05:59,440 --> 03:06:07,160 BECAUSE THEY DON'T LIKE IN THE 4290 03:06:07,160 --> 03:06:17,440 MOUTH -- WHAT -- 4291 03:06:22,520 --> 03:06:27,960 >> OPPORTUNITIES AND MEDICAL AND 4292 03:06:27,960 --> 03:06:32,560 TEST IN AND SO THAT WOULD BE 4293 03:06:32,560 --> 03:06:36,320 TRAINED TO BE LOOKING AT THOSE 4294 03:06:36,320 --> 03:06:40,440 RECORDS FROM A DATA MINING 4295 03:06:40,440 --> 03:06:43,400 PERSPECTIVE AS WELL. 4296 03:06:43,400 --> 03:06:46,760 >> THANK YOU. 4297 03:06:46,760 --> 03:06:51,480 >> THANK YOU, BRUCE. 4298 03:06:51,480 --> 03:07:01,920 >> MY PLEASURE, THANK YOU. 4299 03:07:04,200 --> 03:07:05,400 >> Lynn M. King: NEXT ON THE 4300 03:07:05,400 --> 03:07:07,600 AGENDA WE'RE MOVING FORWARD TO 4301 03:07:07,600 --> 03:07:13,440 THE SIX CONCEPT CLEARANCES. 4302 03:07:13,440 --> 03:07:14,880 CLEARANCE OF CONCEPTS BY 4303 03:07:14,880 --> 03:07:16,080 PRESENTING THE PURPOSE, SCOPE 4304 03:07:16,080 --> 03:07:18,000 AND OBJECTIVES IN A PUBLIC FORUM 4305 03:07:18,000 --> 03:07:20,240 SUCH AS THE COUNCIL MEETING. 4306 03:07:20,240 --> 03:07:22,160 AND GETTING COUNCIL MEMBERS AND 4307 03:07:22,160 --> 03:07:24,760 THE PUBLIC AN OPPORTUNITY TO 4308 03:07:24,760 --> 03:07:25,160 COMMENT. 4309 03:07:25,160 --> 03:07:28,240 FOLLOWING THE PRESENTATIONS BY 4310 03:07:28,240 --> 03:07:30,600 NIDCR STAFF, DESIGNATED COUNCIL 4311 03:07:30,600 --> 03:07:32,640 MEMBERS WILL BE THE DISCUSSION 4312 03:07:32,640 --> 03:07:34,080 FOLLOWED BY A VOTE. 4313 03:07:34,080 --> 03:07:37,560 WHBY THE COUNCIL MEMBERS FOR 4314 03:07:37,560 --> 03:07:38,920 APPROVAL OF THE CONCEPT AS A 4315 03:07:38,920 --> 03:07:41,400 BASIS FOR DEVELOPING A FUTURE 4316 03:07:41,400 --> 03:07:42,840 FUNDING OPPORTUNITY 4317 03:07:42,840 --> 03:07:44,080 ANNOUNCEMENT. 4318 03:07:44,080 --> 03:07:47,640 Dr. AMANDA MELILIO WILL 4319 03:07:47,640 --> 03:07:49,160 PROVIDE THE FIRST CONCEPT SHE'S 4320 03:07:49,160 --> 03:07:53,840 FROM THE CHIEF OF THE INTEGRATED 4321 03:07:53,840 --> 03:07:57,480 PROGRAM OFFICER FOR THE ORAL 4322 03:07:57,480 --> 03:07:58,880 OPPORTUNITIES PATHOGENS AND 4323 03:07:58,880 --> 03:08:02,760 VIRAL DISEASE PROGRAMS. 4324 03:08:02,760 --> 03:08:04,040 >> THANK YOU, LYNN. 4325 03:08:04,040 --> 03:08:05,560 AND THANK YOU FOR THE 4326 03:08:05,560 --> 03:08:07,200 OPPORTUNITY TODAY TO PRESENT 4327 03:08:07,200 --> 03:08:09,600 THIS CONCEPT ON COLLABORATIVE 4328 03:08:09,600 --> 03:08:12,520 SCIENCE TO ACHIEVE DESTRUCTIVE, 4329 03:08:12,520 --> 03:08:15,600 INNOVATION AND DENTAL, ORAL AND 4330 03:08:15,600 --> 03:08:16,880 CRANIOFACIAL RESEARCH AND TODAY 4331 03:08:16,880 --> 03:08:18,440 WE'RE SEEKING COUNCIL CLEARANCE 4332 03:08:18,440 --> 03:08:28,040 ON THIS CONCEPT. 4333 03:08:28,040 --> 03:08:30,160 THE GOAL IS TO ADDRESS 4334 03:08:30,160 --> 03:08:31,240 CHALLENGING QUESTIONS WITH 4335 03:08:31,240 --> 03:08:35,080 POTENTIAL TO SIGNIFICANTLY 4336 03:08:35,080 --> 03:08:36,600 ADVANCE DOC RESEARCH FIELDS. 4337 03:08:36,600 --> 03:08:39,120 WE NEED TO MOVE AWAY FROM A 4338 03:08:39,120 --> 03:08:41,000 REDUCTIONIST VIEW OF SCIENCE AND 4339 03:08:41,000 --> 03:08:42,800 TRANCE DIS PLAIN ARY TEAMS ARE 4340 03:08:42,800 --> 03:08:44,920 REALLY NEEDED TO MAKE THIS 4341 03:08:44,920 --> 03:08:45,600 SHIFT. 4342 03:08:45,600 --> 03:08:47,200 SO, I NEED TO THANK SOME OF THE 4343 03:08:47,200 --> 03:08:48,440 EARLIER SPEAKERS TODAY FOR 4344 03:08:48,440 --> 03:08:50,800 SETTING UP THIS CONCEPT SO 4345 03:08:50,800 --> 03:08:58,880 NICELY AND AS Dr. D D'SOUZA TALD 4346 03:08:58,880 --> 03:09:00,720 ABOUT COLLABORATIVE TEAM SCIENCE 4347 03:09:00,720 --> 03:09:04,320 APPROACH IS REALLY ESSENTIAL IN 4348 03:09:04,320 --> 03:09:05,760 MOVING SOME AREAS OF SCIENCE 4349 03:09:05,760 --> 03:09:06,000 FORWARD. 4350 03:09:06,000 --> 03:09:08,880 SO, I WOULD ALSO JUST LIKE TO 4351 03:09:08,880 --> 03:09:11,720 REITERATE WHAT Dr. CARTER 4352 03:09:11,720 --> 03:09:12,160 MENTIONED EARLIER THAT 4353 03:09:12,160 --> 03:09:12,800 INDIVIDUALS DRIVEN OVATION BUT 4354 03:09:12,800 --> 03:09:15,840 IT TAKES A TEAM TO TACKLE A 4355 03:09:15,840 --> 03:09:18,480 COMPLEX PROBLEM AND THAT IS 4356 03:09:18,480 --> 03:09:19,880 EXACTLY WHAT THIS INITIATIVE IS 4357 03:09:19,880 --> 03:09:21,880 TRYING TO DO. 4358 03:09:21,880 --> 03:09:24,160 IN ADDITION TO THAT, WE ALSO SAW 4359 03:09:24,160 --> 03:09:25,480 EXCELLENT EXAMPLES OF TEAM 4360 03:09:25,480 --> 03:09:27,480 SCIENCE IN RESPONSE TO THE 4361 03:09:27,480 --> 03:09:28,520 COVID-19 PANDEMIC. 4362 03:09:28,520 --> 03:09:30,800 WHEN THERE WERE UNPRECEDENTED 4363 03:09:30,800 --> 03:09:32,120 SCIENTIFIC COLLABORATIONS AS 4364 03:09:32,120 --> 03:09:38,440 EXPERTS FROM AROUND THE WORLD 4365 03:09:38,440 --> 03:09:40,560 CAPE TOGETHER ASK COLLABORATED 4366 03:09:40,560 --> 03:09:46,440 TO FACE THAT CAUSE AND THE 4367 03:09:46,440 --> 03:09:46,720 PANDEMIC. 4368 03:09:46,720 --> 03:09:48,960 SO THERE'S A NUMBER OF 4369 03:09:48,960 --> 03:09:49,520 ADVANTAGES TO TEAM SCIENCE. 4370 03:09:49,520 --> 03:09:51,920 THESE INCLUDE ADVANCING 4371 03:09:51,920 --> 03:09:53,320 SCIENTIFIC ASK TECHNOLOGY 4372 03:09:53,320 --> 03:09:54,720 INNOVATIONS BY INCREASING 4373 03:09:54,720 --> 03:09:58,960 RESEARCH IMPACT AND NOVELTY AND 4374 03:09:58,960 --> 03:10:00,840 PRODUCTIVITY AND THEN A TEAM 4375 03:10:00,840 --> 03:10:01,720 SCIENCE APPROACH IS MORE LIKELY 4376 03:10:01,720 --> 03:10:03,840 TO PUT NOVEL COMBINATIONS OF 4377 03:10:03,840 --> 03:10:05,600 WORK TOGETHER AND TO DEVELOP 4378 03:10:05,600 --> 03:10:08,200 WORK THAT INTEGRATES NOVEL IDEAS 4379 03:10:08,200 --> 03:10:12,800 INTO HIGH-IMPACT OUTPUTS. 4380 03:10:12,800 --> 03:10:13,800 TEAM SCIENCE CAN HELP BROADEN 4381 03:10:13,800 --> 03:10:18,360 THE REACH OF RESEARCH FINDINGS 4382 03:10:18,360 --> 03:10:19,800 ACROSS AREAS OF SCIENCE COMPARED 4383 03:10:19,800 --> 03:10:21,360 TO TRADITIONAL APPROACH AND HELP 4384 03:10:21,360 --> 03:10:25,120 SPEED THE GENERATION AND 4385 03:10:25,120 --> 03:10:30,080 DISSEMINATION OF KNOWLEDGE. 4386 03:10:30,080 --> 03:10:31,680 IT CAN HELP INCREASE DIVERSITY 4387 03:10:31,680 --> 03:10:33,440 OF PARTICIPANTS, RESEARCHERS, 4388 03:10:33,440 --> 03:10:35,640 AND THE RESEARCH QUESTIONS. 4389 03:10:35,640 --> 03:10:36,960 SO YOU MIGHT BE ASKING 4390 03:10:36,960 --> 03:10:38,480 YOURSELVES, HOW WILL THIS 4391 03:10:38,480 --> 03:10:43,800 COMPARE TO OTHER MULTI-P.I. 4392 03:10:43,800 --> 03:10:44,120 AWARDS. 4393 03:10:44,120 --> 03:10:49,840 SO THE TRADITIONAL M.P.I. AWARD 4394 03:10:49,840 --> 03:10:51,880 ARE TYPICALLY P.I.s CAN 4395 03:10:51,880 --> 03:10:53,760 DIFFERENT DISCIPLINES WORKING 4396 03:10:53,760 --> 03:10:55,920 TOGETHER, DRAWING ON THEIR 4397 03:10:55,920 --> 03:10:57,120 DISCIPLINARY KNOWLEDGE AS 4398 03:10:57,120 --> 03:11:00,000 ILLUSTRATED BY THESE INDIVIDUALS 4399 03:11:00,000 --> 03:11:01,920 CIRCLES ON THIS GRAPH. 4400 03:11:01,920 --> 03:11:03,960 AND THIS IS MORE TYPICAL FOR 4401 03:11:03,960 --> 03:11:07,240 YOUR TRADITIONAL INVESTIGATOR 4402 03:11:07,240 --> 03:11:09,720 INITIATED RESEARCH AND IN THOSE 4403 03:11:09,720 --> 03:11:11,800 TYPE OF FUNDING OPPORTUNITIES, 4404 03:11:11,800 --> 03:11:13,240 THERE'S ALSO NO REQUIREMENT TO 4405 03:11:13,240 --> 03:11:15,720 HAVE P.I.s WORKING TOGETHER 4406 03:11:15,720 --> 03:11:16,920 ACROSS DISCIPLINES AND SO IN 4407 03:11:16,920 --> 03:11:18,880 THESE TYPE OF SETTINGS, THE P., 4408 03:11:18,880 --> 03:11:20,600 WORKS LARGELY INDEPENDENTLY AND 4409 03:11:20,600 --> 03:11:22,600 ON A RESEARCH PROBLEM IN THEIR 4410 03:11:22,600 --> 03:11:23,680 OWN LAB. 4411 03:11:23,680 --> 03:11:26,640 SO, NEXT CLICK, PLEASE. 4412 03:11:26,640 --> 03:11:28,280 WHILE PROGRAM PROJECT AWARDS, 4413 03:11:28,280 --> 03:11:30,000 THEY BRING TOGETHER MULTIPLE 4414 03:11:30,000 --> 03:11:32,640 INDEPENDENT ANT PROJECTS IN A 4415 03:11:32,640 --> 03:11:34,600 GRADING KNOWLEDGE FROM DIFFERENT 4416 03:11:34,600 --> 03:11:36,760 DISCIPLINES. 4417 03:11:36,760 --> 03:11:38,080 WHILE EACH GROUP BRINGS 4418 03:11:38,080 --> 03:11:39,240 EXPERTISE TO ADDRESS THE 4419 03:11:39,240 --> 03:11:40,520 RESEARCH PROBLEM THEY'RE WORKING 4420 03:11:40,520 --> 03:11:42,960 ON SEPARATE SCIENTIFIC PARTS OF 4421 03:11:42,960 --> 03:11:45,840 THE PROBLEM WHICH ARE LATER 4422 03:11:45,840 --> 03:11:46,320 INTEGRATED. 4423 03:11:46,320 --> 03:11:48,880 NEXT CLICK, PLEASE. 4424 03:11:48,880 --> 03:11:51,520 WHILE A TRUE TEAM SCIENCE 4425 03:11:51,520 --> 03:11:53,280 APPROACH, WE'RE LOOKING AT A 4426 03:11:53,280 --> 03:11:56,080 SINGLE WELL INTEGRATED RESEARCH 4427 03:11:56,080 --> 03:12:00,680 PLAN WITH A SINGLE DISCIPLINARY 4428 03:12:00,680 --> 03:12:00,960 PERSPECTIVE. 4429 03:12:00,960 --> 03:12:03,280 AND THIS ALLOWS FOR AN 4430 03:12:03,280 --> 03:12:04,400 INTEGRATED TEAM TO BRING 4431 03:12:04,400 --> 03:12:05,640 COMPLIMENTARY APPROACHES TO 4432 03:12:05,640 --> 03:12:07,040 ACCOMPLISH A UNION FIGHT 4433 03:12:07,040 --> 03:12:08,600 SCIENTIFIC GOAL SO WE'RE REALLY 4434 03:12:08,600 --> 03:12:10,240 THINKING ABOUT THAT UNIFIED 4435 03:12:10,240 --> 03:12:14,640 SCIENTIFIC GOAL HERE AND THIS 4436 03:12:14,640 --> 03:12:15,400 INTEGRATED EFFORT WOULD BE 4437 03:12:15,400 --> 03:12:17,520 REQUIRED TO HAVE THREE TO SIX 4438 03:12:17,520 --> 03:12:20,600 P.I.s WHO WOULD EACH BRING 4439 03:12:20,600 --> 03:12:22,360 SCIENTIFIC EXPERTISE AND THE 4440 03:12:22,360 --> 03:12:23,720 PROJECT SHOULD BE COHESIVE AND 4441 03:12:23,720 --> 03:12:26,520 WELL DEFINED AND A FOCUS ON A 4442 03:12:26,520 --> 03:12:27,720 INDIVIDUAL RESEARCH GOAL THAT IS 4443 03:12:27,720 --> 03:12:30,120 EXPECTED TO YIELD A SPECIFIC 4444 03:12:30,120 --> 03:12:31,160 OUTCOME OR DELIVERABLE BY THE 4445 03:12:31,160 --> 03:12:32,600 END OF THE PROJECT PERIOD. 4446 03:12:32,600 --> 03:12:34,680 SO THIS IS NOT MEANT FOR AN 4447 03:12:34,680 --> 03:12:36,600 INCREMENTAL ADVANCEMENTS. 4448 03:12:36,600 --> 03:12:38,440 AND FURTHERMORE, THIS CONCEPT 4449 03:12:38,440 --> 03:12:40,160 SUPPORTS THE IDEA OF BRINGING 4450 03:12:40,160 --> 03:12:42,480 TOGETHER NEW INTERSECTIONS OF 4451 03:12:42,480 --> 03:12:47,440 EXPERTISE AND THEY DID NOT 4452 03:12:47,440 --> 03:12:48,560 PREVIOUSLY EXIST REGARDLESS OF 4453 03:12:48,560 --> 03:12:50,080 THE TEAM OF INVESTIGATORS IS 4454 03:12:50,080 --> 03:12:51,880 NEWLY COLLABORATING OR HAS 4455 03:12:51,880 --> 03:12:53,880 COLLABORATED IN THE PAST. 4456 03:12:53,880 --> 03:12:59,920 NEXT SLIDE, PLEASE. 4457 03:12:59,920 --> 03:13:06,360 SO, AS I MENTIONED, THE GOALS TO 4458 03:13:06,360 --> 03:13:08,400 ADDRESS AMBITIOUS AND CHARGING 4459 03:13:08,400 --> 03:13:09,840 RESEARCH QUESTIONS OF HIGH 4460 03:13:09,840 --> 03:13:10,440 PRIORITY TO NIDCR. 4461 03:13:10,440 --> 03:13:12,320 SO THE FIRST SET OF CHALLENGING 4462 03:13:12,320 --> 03:13:14,680 AND DISRUPTIVE TOPICS THAT THIS 4463 03:13:14,680 --> 03:13:17,600 CONCEPT WILL ADDRESS ARE THE 4464 03:13:17,600 --> 03:13:19,000 FOLLOWING -- PATIENT-CONTROLLED 4465 03:13:19,000 --> 03:13:20,640 TECHNOLOGIES TO REDUCE HEALTH 4466 03:13:20,640 --> 03:13:22,200 DISPARITIES AND THEY SHOULD DRAW 4467 03:13:22,200 --> 03:13:24,560 BEST PRACTICES FROM OTHER 4468 03:13:24,560 --> 03:13:25,080 FIELDS. 4469 03:13:25,080 --> 03:13:27,760 MEDICINE TO IMPROVE ORAL HEALTH. 4470 03:13:27,760 --> 03:13:29,920 NOVEL APPROACHES FOR PREVENTION 4471 03:13:29,920 --> 03:13:32,640 OF CHILDHOOD CARRIES TO 4472 03:13:32,640 --> 03:13:35,000 SIGNIFICANTLY REDUCE INCIDENTS 4473 03:13:35,000 --> 03:13:37,160 OF DISEASE. 4474 03:13:37,160 --> 03:13:39,000 NOVEL NON OPIOID FARM OWE 4475 03:13:39,000 --> 03:13:41,760 THERAPY APPROACHES FOR 4476 03:13:41,760 --> 03:13:44,000 DOC-RELATED PAIN THAT MINIMIZES 4477 03:13:44,000 --> 03:13:46,840 SIDE EFFECTS AND DENTAL 4478 03:13:46,840 --> 03:13:51,880 RESTORATIVE SYSTEMS WITH LIFE 4479 03:13:51,880 --> 03:13:52,920 THAT EXCEEDS COMMERCIAL 4480 03:13:52,920 --> 03:13:54,240 MATERIALS AND NOVEL APPROACHES 4481 03:13:54,240 --> 03:13:56,280 TO ADVANCE PREVENTION AND 4482 03:13:56,280 --> 03:13:57,240 THERAPEUTICS STRATEGIES TO 4483 03:13:57,240 --> 03:13:59,000 MANAGE HIV AND ITS ORAL 4484 03:13:59,000 --> 03:14:02,800 MANIFESTATIONS AND 4485 03:14:02,800 --> 03:14:03,160 CO-MORBIDITIES. 4486 03:14:03,160 --> 03:14:05,400 AS YOU CAN ENVISION, ALL THESE 4487 03:14:05,400 --> 03:14:08,040 TOPICS WOULD REALLY BRING 4488 03:14:08,040 --> 03:14:09,040 TOGETHER VARIOUS INTERSECTIONS 4489 03:14:09,040 --> 03:14:11,160 OF EXPERTISE TO REALLY COME UP 4490 03:14:11,160 --> 03:14:13,760 WITH INNOVATIVE AND DISRUPTIVE 4491 03:14:13,760 --> 03:14:15,920 WAYS TO SOLVE THESE PROBLEMS. 4492 03:14:15,920 --> 03:14:17,200 AND FOR EXAMPLE, ONE CAN 4493 03:14:17,200 --> 03:14:19,920 ENVISION THAT A 4494 03:14:19,920 --> 03:14:21,120 PATIENT-CONTROLLED TECHNOLOGIES 4495 03:14:21,120 --> 03:14:22,640 TO REDUCE HEALTH DISPARITIES 4496 03:14:22,640 --> 03:14:24,640 WOULD INVOLVE ENGINEERS, 4497 03:14:24,640 --> 03:14:26,240 CLINICIANS, BEHAVIORAL 4498 03:14:26,240 --> 03:14:27,680 SCIENTISTS, PERHAPS 4499 03:14:27,680 --> 03:14:28,920 MICROBIOLOGISTS IF THE 4500 03:14:28,920 --> 03:14:30,680 TECHNOLOGY WAS IN THE INTRA ORAL 4501 03:14:30,680 --> 03:14:31,600 ENVIRONMENT AND THROUGH ALL 4502 03:14:31,600 --> 03:14:33,640 THESE RESEARCH OPPORTUNITIES, WE 4503 03:14:33,640 --> 03:14:34,680 ALSO THINK THAT THERE SHOULD BE 4504 03:14:34,680 --> 03:14:37,520 A FOCUS ON DATA SCIENCE AND THAT 4505 03:14:37,520 --> 03:14:39,320 REALLY IS CRUCIAL SO INVOLVEMENT 4506 03:14:39,320 --> 03:14:41,280 OF DATA SCIENTISTS ARE 4507 03:14:41,280 --> 03:14:43,080 COMPUTATIONAL BIOLOGISTS IS ALSO 4508 03:14:43,080 --> 03:14:45,160 SEEN AS AN ESSENTIAL PART OF 4509 03:14:45,160 --> 03:14:45,360 THIS. 4510 03:14:45,360 --> 03:14:49,200 SO NEXT SLIDE, PLEASE. 4511 03:14:49,200 --> 03:14:51,000 FROM HERE I WILL TURN IT OVER TO 4512 03:14:51,000 --> 03:14:54,880 THE THREE CONCEPTS COUNCIL 4513 03:14:54,880 --> 03:14:59,520 REVIEWERS AND I'M HAPPY TO THEN 4514 03:14:59,520 --> 03:15:02,360 ADDRESS ANY QUESTIONS. 4515 03:15:02,360 --> 03:15:03,720 >> WHICH ONE OF WOULD YOU LIKE 4516 03:15:03,720 --> 03:15:05,480 TO PRESENT FIRST? 4517 03:15:05,480 --> 03:15:06,280 >> I WILL. 4518 03:15:06,280 --> 03:15:07,760 >> I WOULD LIKE TO. 4519 03:15:07,760 --> 03:15:12,320 >> SO, THANK YOU. 4520 03:15:12,320 --> 03:15:15,160 I HAVE A LOT OF ENTHUSIASM FOR 4521 03:15:15,160 --> 03:15:16,240 THIS CONCEPT. 4522 03:15:16,240 --> 03:15:19,080 I THINK IT'S VERY ATTRACTIVE FOR 4523 03:15:19,080 --> 03:15:20,240 SEVERAL REASONS. 4524 03:15:20,240 --> 03:15:23,360 I DON'T THINK ANY OF THIS WOULD 4525 03:15:23,360 --> 03:15:24,200 DISAGREE THAT TEAM SCIENCE IS 4526 03:15:24,200 --> 03:15:25,600 REALLY COME TO THE FOREFRONT AND 4527 03:15:25,600 --> 03:15:28,720 WE ALL UNDERSTAND THE POWER OF 4528 03:15:28,720 --> 03:15:29,160 THAT. 4529 03:15:29,160 --> 03:15:32,400 THIS PARTICULAR MECHANISM IS 4530 03:15:32,400 --> 03:15:33,480 UNLIKE ANY OTHER NIDCR MECHANISM 4531 03:15:33,480 --> 03:15:34,720 AND THAT IS WHERE THE POWER 4532 03:15:34,720 --> 03:15:38,680 LIES, I THINK, IN THE FACT THAT 4533 03:15:38,680 --> 03:15:41,520 IT REQUIRES, AS AMANDA SAID, A 4534 03:15:41,520 --> 03:15:43,320 SINGLE, WELL INTEGRATED 4535 03:15:43,320 --> 03:15:43,720 QUESTION. 4536 03:15:43,720 --> 03:15:45,320 AND BRINGING SCIENTISTS TOGETHER 4537 03:15:45,320 --> 03:15:47,720 IN THIS WAY, IN THIS TYPE OF 4538 03:15:47,720 --> 03:15:48,960 TEAM, WHERE THEY ALL ARE 4539 03:15:48,960 --> 03:15:50,760 BRINGING THEIR EXPERTISE TO BEAR 4540 03:15:50,760 --> 03:15:53,960 ON A SINGLE UNIFIED VERY 4541 03:15:53,960 --> 03:15:55,760 IMPORTANT PROBLEM, IS SOMETHING 4542 03:15:55,760 --> 03:15:59,280 THAT I THINK IS LIKELY TO BE 4543 03:15:59,280 --> 03:16:01,320 VERY -- TO CREATE VERY 4544 03:16:01,320 --> 03:16:03,120 TRANSFORMATIVE DISCOVERY AND 4545 03:16:03,120 --> 03:16:04,800 KNOWLEDGE AND I WILL SAY THE 4546 03:16:04,800 --> 03:16:06,440 POSSIBLE ISSUES I SEE ARE IT 4547 03:16:06,440 --> 03:16:10,160 WILL TAKE SOME TIME FOR PIs TO 4548 03:16:10,160 --> 03:16:11,600 UNDERSTAND THIS MECHANISM AND 4549 03:16:11,600 --> 03:16:14,080 WE'RE USED TO MORE TRADITIONAL 4550 03:16:14,080 --> 03:16:17,160 MECHANISMS, MULTI P.I.s AND AS 4551 03:16:17,160 --> 03:16:18,720 MENTIONED, OR PROGRAM PROJECTS 4552 03:16:18,720 --> 03:16:20,160 WITH INDIVIDUAL PROJECTS THAT 4553 03:16:20,160 --> 03:16:23,960 HAVE SYNERGY AND HERE, EVERYONE 4554 03:16:23,960 --> 03:16:26,000 COMES TOGETHER AND WORKS 4555 03:16:26,000 --> 03:16:26,280 TOGETHER. 4556 03:16:26,280 --> 03:16:28,280 SO, I THINK IT WOULDN'T BE A 4557 03:16:28,280 --> 03:16:29,800 SURPRISE IF THERE'S KIND OF A 4558 03:16:29,800 --> 03:16:31,840 LEARNING PERIOD FOR THE 4559 03:16:31,840 --> 03:16:34,560 APPLICANTS AND I THINK THAT WITH 4560 03:16:34,560 --> 03:16:35,640 EDUCATION, FREE EDUCATION AS I 4561 03:16:35,640 --> 03:16:40,960 KNOW THAT YOU WILL DO, THEY WILN 4562 03:16:40,960 --> 03:16:43,320 WHAT THIS MECHANISM IS ABOUT AND 4563 03:16:43,320 --> 03:16:44,520 HOW TO CONSTRUCT A SUCCESSFUL 4564 03:16:44,520 --> 03:16:45,040 PROJECT. 4565 03:16:45,040 --> 03:16:46,520 AND ALSO, MANAGEMENT OF THE TEAM 4566 03:16:46,520 --> 03:16:48,480 WILL BE CRITICAL AND PERHAPS 4567 03:16:48,480 --> 03:16:50,120 MANAGEMENT OF 24 TYPE OF TEAM 4568 03:16:50,120 --> 03:16:51,800 WHERE THERE ARE PIs ALL 4569 03:16:51,800 --> 03:16:53,960 WORKING VERY CLOSELY TOGETHER, 4570 03:16:53,960 --> 03:16:56,560 WITH NO ONE SINGLE P.I.s IS 4571 03:16:56,560 --> 03:16:58,360 SOMETHING THAT MIGHT BE A LITTLE 4572 03:16:58,360 --> 03:17:00,760 FOREIGN TO SOME P.I.s SO, 4573 03:17:00,760 --> 03:17:02,560 THOSE ARE MY COMMENTS AND IN 4574 03:17:02,560 --> 03:17:03,600 ADDITION, I THINK WE HAD 4575 03:17:03,600 --> 03:17:05,960 DISCUSSED THAT PERHAPS THE 4576 03:17:05,960 --> 03:17:08,840 TARGET AREAS SHOULD BE REVISITED 4577 03:17:08,840 --> 03:17:09,720 FAIRLY FREQUENTLY SO THAT YOU 4578 03:17:09,720 --> 03:17:11,200 SELECT THOSE THAT ARE LIKELY TO 4579 03:17:11,200 --> 03:17:12,760 BENEFIT FROM THIS MECHANISM, THE 4580 03:17:12,760 --> 03:17:19,080 MOST AND BE THE MOST FRUITFUL. 4581 03:17:19,080 --> 03:17:27,840 >> THANK YOU. 4582 03:17:27,840 --> 03:17:31,760 >> SO, I GROW WITH EVERYTHING 4583 03:17:31,760 --> 03:17:33,360 THAT WAS SAID. 4584 03:17:33,360 --> 03:17:35,480 I THINK THIS IS A REALLY 4585 03:17:35,480 --> 03:17:37,280 IMPORTANT CONCEPT. 4586 03:17:37,280 --> 03:17:39,280 SO, JUST TO ADD A LITTLE BIT OF 4587 03:17:39,280 --> 03:17:39,720 PERSPECTIVE. 4588 03:17:39,720 --> 03:17:40,840 MY GROUP IS LOCATED NOT AT A 4589 03:17:40,840 --> 03:17:43,240 UNIVERSITY BUT AT A NATIONAL LAB 4590 03:17:43,240 --> 03:17:45,440 WHERE WE HAVE HISTORICALLY USED 4591 03:17:45,440 --> 03:17:47,360 TEAM SCIENCE APPROACH TO TACKLE 4592 03:17:47,360 --> 03:17:49,040 GRAND CHARGE AND SCIENCE THAT 4593 03:17:49,040 --> 03:17:50,880 TEND TO BE TOO DIFFICULT TO 4594 03:17:50,880 --> 03:17:53,280 SOLVE BY INDIVIDUALS SINGLE 4595 03:17:53,280 --> 03:17:54,240 INVESTIGATORS GROUPS. 4596 03:17:54,240 --> 03:17:56,360 AND SO HERE AT THE NATIONAL LAB 4597 03:17:56,360 --> 03:17:59,320 THIS APPROACH REALLY AROSE OUT 4598 03:17:59,320 --> 03:18:00,840 OF PHYSICAL TICKS RESEARCH WHERE 4599 03:18:00,840 --> 03:18:02,880 THE NEED TO LARGE SHARED 4600 03:18:02,880 --> 03:18:04,400 IMPLEMENTATION PROGRAMS NEED TO 4601 03:18:04,400 --> 03:18:05,920 ASSEMBLE THESE 4602 03:18:05,920 --> 03:18:06,600 MULTI-DISCIPLINARY TEAMS AND 4603 03:18:06,600 --> 03:18:09,960 FIND WAYS TO INCENTIVISE AND 4604 03:18:09,960 --> 03:18:11,520 REWARD THEM IN WORKING CLOSELY 4605 03:18:11,520 --> 03:18:13,640 TOGETHER BUT THIS HAS GUN A MORE 4606 03:18:13,640 --> 03:18:15,080 RECENTLY APPLIED WITH GREAT 4607 03:18:15,080 --> 03:18:17,200 SUCCESS AND THE BIOMEDICAL SPACE 4608 03:18:17,200 --> 03:18:22,280 SO MOST ♪LY NOTELY FOR THE GENOE 4609 03:18:22,280 --> 03:18:23,600 INSTITUTE IT'S MY PERSONAL 4610 03:18:23,600 --> 03:18:25,520 PERSPECTIVE AND WHY I AM SO 4611 03:18:25,520 --> 03:18:32,680 APPRECIATIVE OF THIS AND ALSO, 4612 03:18:32,680 --> 03:18:35,520 TO BE PART OF THE FAITH-BASED 4613 03:18:35,520 --> 03:18:39,560 CONSORTIUM SINCE THE INCEPTION A 4614 03:18:39,560 --> 03:18:42,040 DECADE AGO AND I'VE SEEN 4615 03:18:42,040 --> 03:18:43,560 BRINGING TOGETHER 4616 03:18:43,560 --> 03:18:44,840 MULTI-DISCIPLINARY RESEARCHERS 4617 03:18:44,840 --> 03:18:47,280 AND FACILITATED BY A SUSTAINABLE 4618 03:18:47,280 --> 03:18:57,840 AND SUPER FUNDING STRUCTURE AND 4619 03:18:58,880 --> 03:19:00,480 DESIGNED TO FOSTER SUCH 4620 03:19:00,480 --> 03:19:02,320 COLLABORATION IN OTHER AREAS OFF 4621 03:19:02,320 --> 03:19:06,160 THE MISSION MOVING FORWARD AND I 4622 03:19:06,160 --> 03:19:08,320 THINK THAT IT WILL CREATE 4623 03:19:08,320 --> 03:19:10,200 IMPACTFUL OUTCOMES MY ONLY 4624 03:19:10,200 --> 03:19:14,200 COMMENT IS THAT I WOULD 4625 03:19:14,200 --> 03:19:16,120 ENCOURAGE NIDCR TO CONSIDER NOT 4626 03:19:16,120 --> 03:19:17,640 RESTRICTING ITS STRICTLY TO THE 4627 03:19:17,640 --> 03:19:28,120 FIVE FOCUS AREAS WITHOUT THE 4628 03:19:40,080 --> 03:19:40,960 SCOPE TO THOSE. 4629 03:19:40,960 --> 03:19:43,320 THAT SAID, WITH OR WITHOUT I'M 4630 03:19:43,320 --> 03:19:44,480 EXCITE BESIDE THIS CONCEPT AND 4631 03:19:44,480 --> 03:19:54,800 FULLY SUPPORTIVE. 4632 03:19:58,680 --> 03:19:58,840 >> 4633 03:19:58,840 --> 03:20:04,560 >> HE COMPLA EXPLAINED OUR SUPPE 4634 03:20:04,560 --> 03:20:06,880 ARE IN DEEP SUPPORT FOR 4635 03:20:06,880 --> 03:20:08,320 ENCOURAGEMENT OF THIS TEAM 4636 03:20:08,320 --> 03:20:09,760 SCIENCE AND I WILL JUST 4637 03:20:09,760 --> 03:20:16,280 REITERATE THAT YEAH, I THINK 4638 03:20:16,280 --> 03:20:26,720 THAT HAVE ANYTHING TO ADD. 4639 03:20:38,440 --> 03:20:40,280 THIS ISSUE OF THE HAVING TO 4640 03:20:40,280 --> 03:20:41,560 DEFINED AREAS I DO THINK IT'S 4641 03:20:41,560 --> 03:20:43,480 SOMETHING THAT ALL OF US HAVE A 4642 03:20:43,480 --> 03:20:50,120 LITTLE BIT OF QUESTIONS ABOUT 4643 03:20:50,120 --> 03:21:00,640 AND -- WITHOUT HAVING TO DECIDE 4644 03:21:16,440 --> 03:21:22,520 WHAT THOSE TOPICS ARE. 4645 03:21:22,520 --> 03:21:23,480 >> ANY COMMENTS OR QUESTIONS 4646 03:21:23,480 --> 03:21:26,520 ABOUT THIS CONCEPT? 4647 03:21:26,520 --> 03:21:28,320 >> I HAVE A COMMENT. 4648 03:21:28,320 --> 03:21:30,160 ONE IS THAT THERE WILL NEEDS TO 4649 03:21:30,160 --> 03:21:32,720 BE A MECHANISM TO SHARE CREDIT 4650 03:21:32,720 --> 03:21:34,040 FOR APPOINTMENT AND PROMOTIONS 4651 03:21:34,040 --> 03:21:41,200 IT'S VERY IMPORTANT TO BE P.I. 4652 03:21:41,200 --> 03:21:46,880 AND YOU HAVE TO IDENTIFY THEM AS 4653 03:21:46,880 --> 03:21:49,720 P.I.s AND THE CREDIT IS NOT 4654 03:21:49,720 --> 03:21:50,520 SHARED EQUALLY IS. 4655 03:21:50,520 --> 03:21:57,960 >> SO IT IS AN PMI THERE'S A 4656 03:21:57,960 --> 03:22:01,600 CONTACT PI AND OTHER PIs AND 4657 03:22:01,600 --> 03:22:06,800 IT'S A LESSER STATUS AND IT'S. 4658 03:22:06,800 --> 03:22:08,160 >> I AGREE WITH YOU AND YOU ARE 4659 03:22:08,160 --> 03:22:09,440 COMING FROM A PRACTICAL 4660 03:22:09,440 --> 03:22:10,640 STANDPOINT WHICH IS OUR 4661 03:22:10,640 --> 03:22:11,600 UNIVERSITY ISSUE, RIGHT. 4662 03:22:11,600 --> 03:22:12,040 >> YES. 4663 03:22:12,040 --> 03:22:13,360 >> IT'S REALLY UNIVERSITIES NEED 4664 03:22:13,360 --> 03:22:23,880 TO GRAPPLE WITH THIS ISSUE AND 4665 03:22:31,800 --> 03:22:32,760 IT'S UNTORT AT AND THE CHANGE 4666 03:22:32,760 --> 03:22:43,280 AND FOR THE UNIVERSITY LEVEL. 4667 03:22:47,240 --> 03:22:50,280 IS THAT WAY OF CHANGE SWEEPING 4668 03:22:50,280 --> 03:22:52,640 THROUGH AND THAT IT'S FROM THE 4669 03:22:52,640 --> 03:22:57,960 SUCCESS OF HIGH-RISK HIGH GAIN 4670 03:22:57,960 --> 03:23:00,120 THAT ARE DISRUPTIVE THAT'S HOW 4671 03:23:00,120 --> 03:23:04,640 THE GPS WAS CREATE AND SOL, THEY 4672 03:23:04,640 --> 03:23:07,160 JUST APPOINTED AND PRESIDENT 4673 03:23:07,160 --> 03:23:09,280 JUST ANNOUNCED HIS CHOICE FOR 4674 03:23:09,280 --> 03:23:12,200 DIRECTOR OF ARPA-H WHICH USES 4675 03:23:12,200 --> 03:23:13,600 REALLY THE PRINCIPLES CAPTURED 4676 03:23:13,600 --> 03:23:16,840 IN THIS CONCEPT AND SO KEEPING 4677 03:23:16,840 --> 03:23:27,080 AN EYE OUT ON. 4678 03:23:58,880 --> 03:24:00,440 >> -- SO THERE ARE OPPORTUNITIES 4679 03:24:00,440 --> 03:24:02,480 FOR US HERE. 4680 03:24:02,480 --> 03:24:07,640 >> YEAH, I'M JUST ECHOING THAT 4681 03:24:07,640 --> 03:24:09,760 SPECIFICALLY THIS TYPE OF 4682 03:24:09,760 --> 03:24:11,360 APPROACH HAS BEEN DONE RECENTLY 4683 03:24:11,360 --> 03:24:14,080 AT A FEW DIFFERENT INSTITUTES 4684 03:24:14,080 --> 03:24:16,640 ACROSS NIH AND THEY ARE ALL 4685 03:24:16,640 --> 03:24:19,840 RELATIVELY NEW SO NIH EMS WAS 4686 03:24:19,840 --> 03:24:21,840 THE FIRST TO PUT A MECHANISM 4687 03:24:21,840 --> 03:24:26,240 SIMILAR TO THIS FORWARD AND 4688 03:24:26,240 --> 03:24:28,720 NIDCR AND PUT THIS OUT AS WELL 4689 03:24:28,720 --> 03:24:29,760 THIS YEAR. 4690 03:24:29,760 --> 03:24:31,200 >> AND DO YOU SEE THE PROSPECT 4691 03:24:31,200 --> 03:24:37,280 OF PARTNERING WITH NIDCR AND 4692 03:24:37,280 --> 03:24:39,440 WAMC HAS A BIG ROLE IN CREATING 4693 03:24:39,440 --> 03:24:44,000 IS THAT LEVEL PLAYING FIELD IN 4694 03:24:44,000 --> 03:24:48,120 AK DEEMIA SO THAT TEAM SCIENCE 4695 03:24:48,120 --> 03:24:58,280 IS NOT SQUISHED OR DEVALUED. 4696 03:24:58,280 --> 03:24:59,680 AND THEY CAN CHANGE CULTURE IN 4697 03:24:59,680 --> 03:25:00,840 AN INSTITUTION. 4698 03:25:00,840 --> 03:25:05,440 >> BEYOND ALL SCOPE. 4699 03:25:05,440 --> 03:25:08,040 >> SOME OF THE REST OF US SHOULD 4700 03:25:08,040 --> 03:25:08,920 DO THAT TOO. 4701 03:25:08,920 --> 03:25:14,400 >> I'VE GIT'S A CHANGE,ABSOLUTE. 4702 03:25:14,400 --> 03:25:16,960 I WANTED TO SAY -- 4703 03:25:16,960 --> 03:25:18,760 >> JUST SOME OF MY EXPERIENCE, 4704 03:25:18,760 --> 03:25:20,240 I'VE HAD SOME EXPERIENCE WITH 4705 03:25:20,240 --> 03:25:23,080 THE NIGMS MECHANISM AND THAT'S 4706 03:25:23,080 --> 03:25:24,600 MY COMMENTS THAT PI IS NOT 4707 03:25:24,600 --> 03:25:26,200 REALLY UNDERSTANDING THE 4708 03:25:26,200 --> 03:25:27,200 MECHANISM CAME FROM BECAUSE 4709 03:25:27,200 --> 03:25:32,600 EARLY ON THERE, A LOT OF THE 4710 03:25:32,600 --> 03:25:34,440 APPLICATIONS LOOK LIKE PROGRAM 4711 03:25:34,440 --> 03:25:36,760 PROJECT GRANTS AND WE WERE WOVEN 4712 03:25:36,760 --> 03:25:39,120 TOGETHER BUT IT WASN'T REALLY 4713 03:25:39,120 --> 03:25:40,080 WHAT THE MECHANISM WAS AFTER SO 4714 03:25:40,080 --> 03:25:41,560 PERHAPS WE CAN LEARN FROM THAT. 4715 03:25:41,560 --> 03:25:42,920 >> YEAH. 4716 03:25:42,920 --> 03:25:43,360 DEFINITELY. 4717 03:25:43,360 --> 03:25:44,480 AND THAT IS WHAT I WAS GOING TO 4718 03:25:44,480 --> 03:25:46,000 SAY TOO. 4719 03:25:46,000 --> 03:25:48,240 WE CAN ALSO CERTAINLY WE CAN 4720 03:25:48,240 --> 03:25:51,200 DISCUSS WITH MY COLLEAGUES AT 4721 03:25:51,200 --> 03:25:52,840 NIGMS ABOUT THE EXPERIENCE OF 4722 03:25:52,840 --> 03:25:54,880 THE MULTI-PI APPROACH AND THE 4723 03:25:54,880 --> 03:25:57,160 TEAM SCIENCE APPROACH AND HOW IF 4724 03:25:57,160 --> 03:25:58,600 THEY FEEL THEY'VE SEEN EFFECTS 4725 03:25:58,600 --> 03:26:00,600 AT THE UNIVERSITY LEVEL OF 4726 03:26:00,600 --> 03:26:03,000 CREDIT AND THAT AND AS Dr. 4727 03:26:03,000 --> 03:26:04,440 GRAVES MENTIONED. 4728 03:26:04,440 --> 03:26:05,640 >> THANK YOU. 4729 03:26:05,640 --> 03:26:10,080 >> AND MAYBE -- MAYBE WE ALL THE 4730 03:26:10,080 --> 03:26:12,560 TO HAVE AN WEBINAR ON CONDITION 4731 03:26:12,560 --> 03:26:12,760 FOLKS. 4732 03:26:12,760 --> 03:26:14,880 >> ABSOLUTELY. 4733 03:26:14,880 --> 03:26:16,520 THAT IS PLANNED AS PART OF THIS. 4734 03:26:16,520 --> 03:26:22,320 >> THANK YOU. 4735 03:26:22,320 --> 03:26:23,040 >> Lynn M. King: ANYTHING ELSE? 4736 03:26:23,040 --> 03:26:26,840 ANY OTHER COMMENTS? 4737 03:26:26,840 --> 03:26:32,400 WE CAN MOVE ON TO DOES A 4738 03:26:32,400 --> 03:26:33,480 COUNCILMEMBER LIKE TO MAKE A 4739 03:26:33,480 --> 03:26:37,680 MOTION TO APPROVE THIS CONCEPT? 4740 03:26:37,680 --> 03:26:39,840 >> I WOULD LIKE TO MAKE A 4741 03:26:39,840 --> 03:26:40,040 MOTION. 4742 03:26:40,040 --> 03:26:40,640 >> LEE. 4743 03:26:40,640 --> 03:26:41,680 >> THANK YOU. 4744 03:26:41,680 --> 03:26:43,280 >> AND WOULD ANYONE LIKE TO 4745 03:26:43,280 --> 03:26:43,520 SECOND? 4746 03:26:43,520 --> 03:26:49,280 >> I CAN SECOND IT. 4747 03:26:49,280 --> 03:26:49,480 JACK. 4748 03:26:49,480 --> 03:26:50,200 ALL IN FAVOR. 4749 03:26:50,200 --> 03:26:52,640 >> AYE. 4750 03:26:52,640 --> 03:26:58,320 ANY OPPOSED? 4751 03:26:58,320 --> 03:26:59,760 THANK YOU, AMANDA. 4752 03:26:59,760 --> 03:27:06,680 >> THANK YOU. 4753 03:27:06,680 --> 03:27:07,400 >> Lynn M. King: THE NEXT 4754 03:27:07,400 --> 03:27:08,840 CONCEPT WILL BE PRESENTED BY 4755 03:27:08,840 --> 03:27:12,320 CENTER MARGARET GRISIUS. 4756 03:27:12,320 --> 03:27:16,880 AND THE CLINICAL TECHNOLOGIES 4757 03:27:16,880 --> 03:27:23,080 RESEARCH PROGRAM. 4758 03:27:23,080 --> 03:27:25,160 SHOULD SHE WILL PRESENT ON 4759 03:27:25,160 --> 03:27:26,320 MATERNAL HEALTH AND DENTSAL AND 4760 03:27:26,320 --> 03:27:27,520 ORAL AND CRANIOFACIAL HEALTH AND 4761 03:27:27,520 --> 03:27:32,760 DEVELOPMENT OF THEIR OFFSPRING. 4762 03:27:45,720 --> 03:27:46,920 >> GOOD AFTERNOON, THANK YOU FOR 4763 03:27:46,920 --> 03:27:48,080 THE OPPORTUNITY TO PRESENT 4764 03:27:48,080 --> 03:27:48,360 TODAY. 4765 03:27:48,360 --> 03:27:49,840 I'M SEEKING COUNCIL'S 4766 03:27:49,840 --> 03:27:53,600 CONCURRENCE ON THE CONCEPT TITLE 4767 03:27:53,600 --> 03:27:55,120 MATERNAL HEALTH IN THE DENTAL 4768 03:27:55,120 --> 03:27:56,520 ORAL AND CRANIOFACIAL HEALTH AND 4769 03:27:56,520 --> 03:28:02,320 HAVEMENT OF THEIR CHILDREN. 4770 03:28:02,320 --> 03:28:04,240 THE MATERNAL MORBIDITY AND 4771 03:28:04,240 --> 03:28:04,960 MORTALITY RATE IN THE UNITED 4772 03:28:04,960 --> 03:28:06,760 STATES IS ONE OF THE HIGHEST IN 4773 03:28:06,760 --> 03:28:07,800 THE WORLD. 4774 03:28:07,800 --> 03:28:09,360 MATERNAL MORBIDITY AND MORTALITY 4775 03:28:09,360 --> 03:28:11,720 HAS BEEN ASSOCIATED WITH POOR 4776 03:28:11,720 --> 03:28:12,920 PRE-NATAL CARE AND LIMITED 4777 03:28:12,920 --> 03:28:15,000 ACCESS TO HOSPITALS. 4778 03:28:15,000 --> 03:28:16,440 IT'S RECOGNIZED THE HIGHEST 4779 03:28:16,440 --> 03:28:19,280 RATES OF MATERNAL MORBIDITY AND 4780 03:28:19,280 --> 03:28:22,040 MORTALITY, DISPROPORTIONATELY 4781 03:28:22,040 --> 03:28:24,080 IMPACTS THE UNDER REPRESENTED 4782 03:28:24,080 --> 03:28:25,240 MINORITIES, LOWER SOCIOECONOMIC 4783 03:28:25,240 --> 03:28:27,560 AND RURAL POPULATIONS. 4784 03:28:27,560 --> 03:28:28,880 THERE'S A NATIONWIDE 4785 03:28:28,880 --> 03:28:31,200 PUBLIC-HEALTH AWARENESS OF THE 4786 03:28:31,200 --> 03:28:33,760 NEED TIME PROVE MATERNAL HEALTH. 4787 03:28:33,760 --> 03:28:35,200 THE NIH OFFICE OF THE DIRECTOR 4788 03:28:35,200 --> 03:28:37,440 OFFICE OF WOMEN'S HEALTH AND THE 4789 03:28:37,440 --> 03:28:38,760 INSTITUTE OF CHILD HEALTH AND 4790 03:28:38,760 --> 03:28:40,880 HUMAN DEVELOPMENT, ARE CURRENTLY 4791 03:28:40,880 --> 03:28:42,160 LEADING THE TASK FORCE ON 4792 03:28:42,160 --> 03:28:43,880 MATERNAL MORTALITY. 4793 03:28:43,880 --> 03:28:45,600 THE WHITE HOUSE IS RECENTLY 4794 03:28:45,600 --> 03:28:48,680 RELEASED THE WHITE HOUSE 4795 03:28:48,680 --> 03:28:49,840 MATERNAL HEALTH BLUE PRINT THAT 4796 03:28:49,840 --> 03:28:51,760 OUTLINES ACTIONS UNDERTAKEN TO 4797 03:28:51,760 --> 03:28:55,240 IMPROVE MATERNAL CARE. 4798 03:28:55,240 --> 03:28:56,360 MATERNAL HEALTH IMPACTS THE 4799 03:28:56,360 --> 03:28:58,600 MOTHER BUT IMPACTS THE 4800 03:28:58,600 --> 03:29:00,040 DEVELOPING CHILD. 4801 03:29:00,040 --> 03:29:01,680 MATERNAL HEALTH AND EXPOSURE 4802 03:29:01,680 --> 03:29:06,320 HAVE BEEN LINKED TO DOC IN THEIR 4803 03:29:06,320 --> 03:29:16,840 CHILDREN AND AND HYPO PLAY SHA 4804 03:29:25,760 --> 03:29:27,440 AND FOR EXAMPLE, CHILDREN WHOSE 4805 03:29:27,440 --> 03:29:29,040 MOTHERS WERE INFECTED WITH ZIKA 4806 03:29:29,040 --> 03:29:31,240 VIRUS DURING PREGNANCY, OFTEN 4807 03:29:31,240 --> 03:29:36,880 SUFFERED FROM MICROCEPHALY AND 4808 03:29:36,880 --> 03:29:39,320 THE TEETH AND CRANIAL STRUCTURES 4809 03:29:39,320 --> 03:29:41,920 ARE DEVELOPING IN UTERO AND IT 4810 03:29:41,920 --> 03:29:44,960 MAYING LINKED TO MATERNAL 4811 03:29:44,960 --> 03:29:47,240 EXPOSURES, FOR EXAMPLE, IN THE 4812 03:29:47,240 --> 03:29:48,400 PRIMARY DEN ADVERTISE HAS BEEN 4813 03:29:48,400 --> 03:29:51,200 ASSOCIATED WITH DIFFERENCES IN 4814 03:29:51,200 --> 03:29:55,440 MATERNAL AND MEET OWE NATAL 4815 03:29:55,440 --> 03:29:59,240 HOMEOSTASIS AND IN THE EX TEETH 4816 03:29:59,240 --> 03:30:01,040 OF CHILDREN WHOSE MOTHERS 4817 03:30:01,040 --> 03:30:04,600 EXPERIENCED STRESS DURING 4818 03:30:04,600 --> 03:30:05,000 PREGNANCY. 4819 03:30:05,000 --> 03:30:07,280 EX FOLEYATED TEETH HAVE BEEN 4820 03:30:07,280 --> 03:30:09,200 USED TO INDICATE MATERNAL 4821 03:30:09,200 --> 03:30:10,440 EXPOSURES AND THE INTENSITY OF 4822 03:30:10,440 --> 03:30:12,280 THE EXPOSURE PROVIDING A WINDOW 4823 03:30:12,280 --> 03:30:14,360 TO FETAL EXPOSURE. 4824 03:30:14,360 --> 03:30:15,680 THE GOAL OF THIS INITIATIVE IS 4825 03:30:15,680 --> 03:30:19,160 TO SUPPORT RESEARCH ON PRE-NATAL 4826 03:30:19,160 --> 03:30:21,040 ENVIRONMENT AND PHYSICAL 4827 03:30:21,040 --> 03:30:22,480 STRESSORS EXPERIENCED DURING 4828 03:30:22,480 --> 03:30:23,960 PREGNANCY THAT EFFECT THEIR 4829 03:30:23,960 --> 03:30:25,680 CHILD'S DENTAL, ORAL AND 4830 03:30:25,680 --> 03:30:27,600 CRANIOFACIAL DEVELOPMENT THROUGH 4831 03:30:27,600 --> 03:30:34,760 ALTERED MATERNAL PHYSIOLOGY. 4832 03:30:34,760 --> 03:30:35,840 GAPS EXIST IN THE UNDERSTANDING 4833 03:30:35,840 --> 03:30:41,160 OF THESE LINKS BETWEEN MATERNAL 4834 03:30:41,160 --> 03:30:42,480 PRE-NATAL HEALTH AND EXPOSURE 4835 03:30:42,480 --> 03:30:44,440 AND DOC. 4836 03:30:44,440 --> 03:30:50,960 EXAMPLES INCLU INDIABETES, LOOPD 4837 03:30:50,960 --> 03:30:51,880 INFECTIOUS ACCIDENTS AND 4838 03:30:51,880 --> 03:30:54,600 EXAMPLES OF MATERNAL PRENATAL 4839 03:30:54,600 --> 03:30:56,760 EXPOSURES INCLUDE TRAUMA, 4840 03:30:56,760 --> 03:30:59,080 DIETARY HABITS, HIGH PROCESSED 4841 03:30:59,080 --> 03:31:00,480 FOODS, OR VEGAN DIET, 4842 03:31:00,480 --> 03:31:02,360 PRESCRIPTION MEDICATIONS, 4843 03:31:02,360 --> 03:31:05,560 SUBSTANCE EXPOSURES, PERHAPS DUE 4844 03:31:05,560 --> 03:31:07,840 TO UNMONITORED WELL WATER, 4845 03:31:07,840 --> 03:31:09,800 TOBACCO PRODUCTS, CANNABIS OR 4846 03:31:09,800 --> 03:31:10,200 OPIOIDS. 4847 03:31:10,200 --> 03:31:11,960 THIS IS AN OPPORTUNITY TO 4848 03:31:11,960 --> 03:31:14,280 IDENTIFY MECHANISMS THAT MAY 4849 03:31:14,280 --> 03:31:17,800 HAVE MODIFY AND RISK FACTORS AND 4850 03:31:17,800 --> 03:31:19,640 LEAD TO THE DEVELOPMENT OF 4851 03:31:19,640 --> 03:31:24,400 POTENTIAL DIAGNOSTIC AND 4852 03:31:24,400 --> 03:31:30,360 MODALITIES WITH OTHER NIH 4853 03:31:30,360 --> 03:31:31,760 INSTITUTES AND OFFICES AND WE'RE 4854 03:31:31,760 --> 03:31:42,240 SEEKING THEIR COLLABORATION. 4855 03:32:20,200 --> 03:32:23,400 >> OBSERVATIONAL AND MECHANISTIC 4856 03:32:23,400 --> 03:32:26,240 STUDIES OF PREGNANT MOTHERS WHO 4857 03:32:26,240 --> 03:32:26,960 HAVE UNDERGONE EMOTIONAL EXPRESS 4858 03:32:26,960 --> 03:32:29,400 AND THE IMPACT ON DEVELOPING 4859 03:32:29,400 --> 03:32:30,240 TEETH AND CRANIOFACIAL 4860 03:32:30,240 --> 03:32:37,320 STRUCTURES OF THEIR OFFSPRING. 4861 03:32:37,320 --> 03:32:39,400 AND THE CHILD DENTAL AND 4862 03:32:39,400 --> 03:32:40,480 CRANIOFACIAL DEVELOPMENT TO GAIN 4863 03:32:40,480 --> 03:32:42,160 A BETTER UNDERSTANDING OF 4864 03:32:42,160 --> 03:32:44,360 UNDERLYING DISEASE MECHANISMS 4865 03:32:44,360 --> 03:32:46,000 AND OBSERVATIONAL AND 4866 03:32:46,000 --> 03:32:47,400 MECHANISTIC STUDIES MONITORING 4867 03:32:47,400 --> 03:32:49,640 THE MATERNAL PRE-NATAL EXPOSURE 4868 03:32:49,640 --> 03:32:51,680 AND THE KOC DEVELOPMENT OF THEIR 4869 03:32:51,680 --> 03:32:52,040 CHILDREN. 4870 03:32:52,040 --> 03:32:53,560 -- DOC DEVELOPMENT OF THEIR 4871 03:32:53,560 --> 03:32:53,880 CHILDREN. 4872 03:32:53,880 --> 03:32:58,320 I'M HAPPY TO TAKE QUESTIONS. 4873 03:32:58,320 --> 03:33:01,000 THE DESIGNATED REVIEWERS AND 4874 03:33:01,000 --> 03:33:03,800 BELIEVE Dr. NICEWONGER WAS 4875 03:33:03,800 --> 03:33:04,600 GOING TO INITIATE THE 4876 03:33:04,600 --> 03:33:04,960 CONVERSATION. 4877 03:33:04,960 --> 03:33:07,200 >> GREAT, THANK YOU VERY MUCH. 4878 03:33:07,200 --> 03:33:09,560 I WANT TO SAY THAT AS REVIEWERS, 4879 03:33:09,560 --> 03:33:12,920 WE HAVE A LOT OF ENTHUSIASM FOR 4880 03:33:12,920 --> 03:33:15,120 THIS CONCEPT RELATE TODAY 4881 03:33:15,120 --> 03:33:17,720 MATERNAL HEALTH AND IMPACT ON 4882 03:33:17,720 --> 03:33:19,160 FETAL AND CHILDHOOD DEVELOPMENT. 4883 03:33:19,160 --> 03:33:20,080 IT'S REALLY TIMELY. 4884 03:33:20,080 --> 03:33:22,680 I MEAN WE HEARD THIS MORNING 4885 03:33:22,680 --> 03:33:25,400 DURING THE REPORT ABOUT HOW 4886 03:33:25,400 --> 03:33:28,920 THERE'S RENEWED EMPHASIS AND 4887 03:33:28,920 --> 03:33:33,480 FOCUS ON THE WHITE HOUSE AND 4888 03:33:33,480 --> 03:33:35,160 NIDCR AND OTHER AGENCIES ON 4889 03:33:35,160 --> 03:33:36,960 IMPROVING MATERNAL HEALTH SO THE 4890 03:33:36,960 --> 03:33:39,320 POTENTIAL FOR PARTNERSHIPS AND 4891 03:33:39,320 --> 03:33:43,560 IS REALLY HIGH AND ALSO, THE 4892 03:33:43,560 --> 03:33:45,960 TECHNOLOGIES AND THE RESOURCES 4893 03:33:45,960 --> 03:33:47,600 THAT HAVE ARE COMING TO THE 4894 03:33:47,600 --> 03:33:51,240 FOREFRONT TO WE CAN MOVE FROM 4895 03:33:51,240 --> 03:33:52,840 OBSERVATIONAL STUDIES TO THESE 4896 03:33:52,840 --> 03:33:54,040 MECHANIC NICE TICKS AND INSIGHTS 4897 03:33:54,040 --> 03:33:56,320 OF THE EFFECT OF MATERNAL HEALTH 4898 03:33:56,320 --> 03:34:02,320 ON DOC TISSUE FORMATION SO I 4899 03:34:02,320 --> 03:34:03,720 APPLAUD THIS CONCEPT AND THE 4900 03:34:03,720 --> 03:34:06,160 GOALS ARE GREAT AND THE RESEARCH 4901 03:34:06,160 --> 03:34:10,760 ON HOW THE MATERNAL HEALTH AND 4902 03:34:10,760 --> 03:34:11,800 PHYSICAL STRESSORS CAN EFFECT 4903 03:34:11,800 --> 03:34:14,920 THE CHILDREN AND THEIR DENTAL, 4904 03:34:14,920 --> 03:34:16,800 ORAL AND CRANIOFACIAL 4905 03:34:16,800 --> 03:34:17,120 DEVELOPMENT. 4906 03:34:17,120 --> 03:34:20,600 AS REVIEWERS, THE CONCEPT WAS 4907 03:34:20,600 --> 03:34:22,360 ALREADY WELL DEFINED AND I THINK 4908 03:34:22,360 --> 03:34:24,240 WE JUST HELPED TO REFINE IT A 4909 03:34:24,240 --> 03:34:28,240 LITTLE BIT MOSTLY IN TERMS OF IS 4910 03:34:28,240 --> 03:34:31,800 HELPING DRAW IN AND OUTSIDE AND 4911 03:34:31,800 --> 03:34:38,520 THE TRADITIONAL AREAS AND MIGHT 4912 03:34:38,520 --> 03:34:43,960 BE IT WOULD BE PART OF THIS AND 4913 03:34:43,960 --> 03:34:47,000 ALSO HIGHLIGHTING THE STUDY OF 4914 03:34:47,000 --> 03:34:48,760 IMPACTS TO THE EMOTIONAL STRESS 4915 03:34:48,760 --> 03:34:50,960 DURING PREGNANCY WOULD BE VERY 4916 03:34:50,960 --> 03:34:53,600 WELCOME. 4917 03:34:53,600 --> 03:34:55,800 AND SO, I'LL TEND IT THAT AND 4918 03:34:55,800 --> 03:35:00,040 LET AMY AND THEIR THOUGHTS BUT 4919 03:35:00,040 --> 03:35:04,480 WE'RE ENTHUSIASTIC ABOUT THIS. 4920 03:35:04,480 --> 03:35:07,280 I CAN ADD THAT YOU DID A GREAT 4921 03:35:07,280 --> 03:35:07,560 JOB. 4922 03:35:07,560 --> 03:35:09,320 I THINK YOU COVERED OUR WHOLE 4923 03:35:09,320 --> 03:35:19,840 CONVERSATION THAT WE HAD AND. 4924 03:36:36,840 --> 03:36:40,000 >> I KIND OF LIKEN IT TO THE 4925 03:36:40,000 --> 03:36:41,440 REIGNS ON A TREE ABOUT WHAT GOES 4926 03:36:41,440 --> 03:36:42,920 ON IN THE LIFE OF THAT TREE. 4927 03:36:42,920 --> 03:36:48,080 WHAT COULD WE LEARN THAT WE CAN 4928 03:36:48,080 --> 03:36:49,120 IN FACT WHAT HAPPENS BEFORE 4929 03:36:49,120 --> 03:36:51,720 SOMEONE GETS PREGNANT EVEN. 4930 03:36:51,720 --> 03:36:54,520 TO BE ABLE TO PREDICT WHAT'S 4931 03:36:54,520 --> 03:36:56,920 GOING TO MAP DOWN THE ROAD. 4932 03:36:56,920 --> 03:36:58,960 WE JUST DON'T HAVE ANYTHING AS 4933 03:36:58,960 --> 03:37:00,760 FAR AS I KNOW THAT ADDRESSES 4934 03:37:00,760 --> 03:37:04,840 THAT SO I'M REALLY ENTHUSIASTIC 4935 03:37:04,840 --> 03:37:06,400 ABOUT IT AND I FULLY SUPPORT 4936 03:37:06,400 --> 03:37:11,440 THIS PROJECT. 4937 03:37:11,440 --> 03:37:12,800 >> ANYBODY ELSE HAVE QUESTIONS 4938 03:37:12,800 --> 03:37:15,640 OR COMMENTS? 4939 03:37:15,640 --> 03:37:19,200 ABOUT THIS CONCEPT? 4940 03:37:19,200 --> 03:37:23,200 >> RENA. 4941 03:37:23,200 --> 03:37:25,960 >> I THINK THE STRIKING DATA 4942 03:37:25,960 --> 03:37:35,040 THAT DIANA BIAN BIANCHI, THE MOL 4943 03:37:35,040 --> 03:37:37,440 TEE MORBIDITY AND MORTALITY WAS 4944 03:37:37,440 --> 03:37:39,600 MOST PREVALENT IN AFRICAN 4945 03:37:39,600 --> 03:37:40,000 AMERICANS WOMEN. 4946 03:37:40,000 --> 03:37:43,480 THEY WERE THE MOST VULNERABLE 4947 03:37:43,480 --> 03:37:46,200 AND SO THAT DISPARITIES ISSUE 4948 03:37:46,200 --> 03:37:50,640 PREVAILS AND OBVIOUSLY EFFECTS 4949 03:37:50,640 --> 03:37:53,560 THE POPULATION. 4950 03:37:53,560 --> 03:37:55,840 AND IT'S PROBABLY A CORRELATION 4951 03:37:55,840 --> 03:37:59,480 WITH PERINATAL AS WELL AND 4952 03:37:59,480 --> 03:38:02,160 INFANT A DEATHS. 4953 03:38:02,160 --> 03:38:11,200 WHY SI DON'T SEE THATDATA. 4954 03:38:11,200 --> 03:38:14,320 >> Lynn M. King: ANY OTHER 4955 03:38:14,320 --> 03:38:15,840 COMMENTS? 4956 03:38:15,840 --> 03:38:23,360 >> OK, ARE WE READY TO VOTE. 4957 03:38:23,360 --> 03:38:24,760 DOES ANYONE HAVE -- WOULD 4958 03:38:24,760 --> 03:38:26,440 SOMEONE LIKE TO MAKE A MOTION TO 4959 03:38:26,440 --> 03:38:27,880 APPROVE THIS CONCEPT? 4960 03:38:27,880 --> 03:38:29,960 >> I WOULD LIKE TO MAKE A MOTION 4961 03:38:29,960 --> 03:38:30,720 TO APPROVE. 4962 03:38:30,720 --> 03:38:31,640 >> Lynn M. King: THANK YOU, LEE. 4963 03:38:31,640 --> 03:38:32,560 >> ANYONE SECOND? 4964 03:38:32,560 --> 03:38:35,920 >> I CAN SECOND IT. 4965 03:38:35,920 --> 03:38:36,080 HAL. 4966 03:38:36,080 --> 03:38:39,240 >> ALL IN FAVOR. 4967 03:38:39,240 --> 03:38:39,560 AYE. 4968 03:38:39,560 --> 03:38:45,640 >> Lynn M. King: ANY OPPOSED? 4969 03:38:45,640 --> 03:38:45,800 OK. 4970 03:38:45,800 --> 03:38:46,120 THANK YOU. 4971 03:38:46,120 --> 03:38:49,280 >> THANK YOU, VERY MUCH. 4972 03:38:49,280 --> 03:38:52,240 >> NEXT CONCEPT WILL BE 4973 03:38:52,240 --> 03:38:55,280 PRESENTED DID I Dr. HONGEN 4974 03:38:55,280 --> 03:38:57,600 YIN, THE PROGRAM OFFICER FOR THE 4975 03:38:57,600 --> 03:38:59,280 HIV/AIDS AND ORAL HEALTH 4976 03:38:59,280 --> 03:39:02,040 RESEARCH PROGRAM. 4977 03:39:02,040 --> 03:39:06,480 AND THE REVIEWERS FOR HER 4978 03:39:06,480 --> 03:39:08,120 CONCEPT WILL BE -- 4979 03:39:10,080 --> 03:39:10,800 THANK YOU. 4980 03:39:10,800 --> 03:39:13,000 GO AHEAD AFTERNOON. 4981 03:39:13,000 --> 03:39:14,840 THANK YOU FOR THIS OPPORTUNITY 4982 03:39:14,840 --> 03:39:18,720 TO PRESENT THE CONCEPT. 4983 03:39:18,720 --> 03:39:22,000 UNDERSTANDING PERSISTENT ORAL 4984 03:39:22,000 --> 03:39:24,560 HPV AND HIV CO-INFECTION AND ITS 4985 03:39:24,560 --> 03:39:33,280 ROLE WITH OROPHARYNGEAL CANCER 4986 03:39:33,280 --> 03:39:33,560 INDUCTION. 4987 03:39:33,560 --> 03:39:36,720 THIS IS FOR THE EPIDEMIOLOGY 4988 03:39:36,720 --> 03:39:39,440 STUDIES IN THE AREA AND THE GOAL 4989 03:39:39,440 --> 03:39:45,760 FOR THE CURRENT CONCEPT IS TO SP 4990 03:39:45,760 --> 03:39:47,000 IS ITS BETTER RESEARCH FOR PER 4991 03:39:47,000 --> 03:39:50,600 IS THE ANT ORAL HIV AND HPV AS 4992 03:39:50,600 --> 03:39:53,400 WELL AS ITS ROLE IN THE 4993 03:39:53,400 --> 03:39:55,800 INDUCTION AND PATHOGENESIS OF 4994 03:39:55,800 --> 03:40:02,880 HPV ASSOCIATED OR CANCER. 4995 03:40:02,880 --> 03:40:04,200 PEOPLE WITH HIV HAVE A GREATER 4996 03:40:04,200 --> 03:40:07,840 RISK TO GET INFECTIONS SUCH AS 4997 03:40:07,840 --> 03:40:10,280 ORAL HPV INFECTION WHICH WAS TWO 4998 03:40:10,280 --> 03:40:14,320 TO FOUR COMPARED WITH HIV 4999 03:40:14,320 --> 03:40:15,840 INACTIVE INDIVIDUALS. 5000 03:40:15,840 --> 03:40:19,040 RECENT SYSTEMIC REVIEWS AND THE 5001 03:40:19,040 --> 03:40:24,600 ANALYSIS SHOWED A STRONG 5002 03:40:24,600 --> 03:40:26,600 EPIDEMICOLOGY EVIDENCE OF THE 5003 03:40:26,600 --> 03:40:27,480 SYNERGISTIC RELATIONSHIP BETWEEN 5004 03:40:27,480 --> 03:40:29,360 THESE TWO VIRUSES. 5005 03:40:29,360 --> 03:40:33,240 ALTHOUGH THE BIOLOGY 5006 03:40:33,240 --> 03:40:35,240 RELATIONSHIP WOULD NOT WELL 5007 03:40:35,240 --> 03:40:35,840 STUDIED. 5008 03:40:35,840 --> 03:40:38,560 SO BESIDES THE HIGH-RISK OF CO 5009 03:40:38,560 --> 03:40:41,960 INFECTION, WHAT IS IMPORTANT TO 5010 03:40:41,960 --> 03:40:43,720 UNDERSTAND THIS WAS TO SHOW THAT 5011 03:40:43,720 --> 03:40:50,640 MORE THAN 20% OF OROPHARYNGEAL 5012 03:40:50,640 --> 03:40:52,440 CANCER SHOW HPV INFECTION AND 5013 03:40:52,440 --> 03:40:55,760 PEOPLE WITH HIV, THIS INSTANCE 5014 03:40:55,760 --> 03:40:58,720 INCREASES TO 80%. 5015 03:40:58,720 --> 03:41:03,760 SO, THE GR STATISTICS ENCOURAGEU 5016 03:41:03,760 --> 03:41:10,240 TO ADVANCE RESEARCH IN THIS 5017 03:41:10,240 --> 03:41:10,600 FIELD. 5018 03:41:10,600 --> 03:41:14,640 IS FOCUSING ON THE (INAUDIBLE) 5019 03:41:14,640 --> 03:41:18,280 IT'S KNOWN THAT ALL ORAL MUCOSAL 5020 03:41:18,280 --> 03:41:21,000 EP THEILIA IS A PERFECT IMMUNITY 5021 03:41:21,000 --> 03:41:26,560 BARRIER TO PROTECT INFECTIONS, 5022 03:41:26,560 --> 03:41:28,760 INFLAMMATION AND CORRAL CANCER 5023 03:41:28,760 --> 03:41:30,760 HOWEVER, ORAL HPV INFECTION CAN 5024 03:41:30,760 --> 03:41:35,320 DAMAGE THIS IMMUNITY BARRIER BY 5025 03:41:35,320 --> 03:41:37,560 BOOST INNATE AND ADAPTIVE 5026 03:41:37,560 --> 03:41:43,160 IMMUNITY IN ORAL EP THEILIA. 5027 03:41:43,160 --> 03:41:45,840 ALTHOUGH THE THERAPY BROUGHT A 5028 03:41:45,840 --> 03:41:47,080 REVOLUTIONARY IMPROVEMENT IN 5029 03:41:47,080 --> 03:41:57,600 TERMS OF MY CONTROL, THAT CAN 5030 03:42:03,040 --> 03:42:04,800 DAMAGE WITH EPITHELIA BARRIER 5031 03:42:04,800 --> 03:42:06,720 AND THE WORSE CASE SCENARIOS THE 5032 03:42:06,720 --> 03:42:14,440 LAWS OF ORAL MUCOSAL EPITHELIAL 5033 03:42:14,440 --> 03:42:17,800 IN HOMEOSTASIS IS IN CANCER 5034 03:42:17,800 --> 03:42:18,600 INDUCTION AND WITHOUT 5035 03:42:18,600 --> 03:42:20,880 PROTECTION, HIGH-RISK HPV ACCESS 5036 03:42:20,880 --> 03:42:23,760 THAT EPITHELIAL CELLS IN 5037 03:42:23,760 --> 03:42:25,080 INTEGRITY TO THE HOST GENOME 5038 03:42:25,080 --> 03:42:27,880 WHICH IS ONE OF THE MOST 5039 03:42:27,880 --> 03:42:31,000 CRITICAL STEPS FOR CANCER 5040 03:42:31,000 --> 03:42:31,600 DEVELOPMENT. 5041 03:42:31,600 --> 03:42:38,480 DESPITE ALL THIS STRONG 5042 03:42:38,480 --> 03:42:47,880 EVIDENCE, THERE ARE GAPS IN OUR 5043 03:42:47,880 --> 03:42:49,040 UNDERSTANDING OF THE 5044 03:42:49,040 --> 03:42:51,080 PATHOGENESIS RELATED TO THE 5045 03:42:51,080 --> 03:42:54,520 PERSISTENT ORAL HPV AND HIV CO 5046 03:42:54,520 --> 03:42:58,360 INFECTION AS WELL AS HOW IT 5047 03:42:58,360 --> 03:43:08,760 CONTRIBUTED TO THE INDUCTION OF 5048 03:43:08,760 --> 03:43:11,280 OROPHARYNGEA. 5049 03:43:11,280 --> 03:43:12,680 >> Marla: CANCER AND IT 5050 03:43:12,680 --> 03:43:14,960 PROVIDES INSIDE INFORMATION FOR 5051 03:43:14,960 --> 03:43:16,960 MECHANISTIC TARGETS CAN FURTHER 5052 03:43:16,960 --> 03:43:20,040 GUIDE THE DEVELOPMENT OF MORE 5053 03:43:20,040 --> 03:43:24,080 EFFICIENT PREVENTIONS AND THE 5054 03:43:24,080 --> 03:43:27,720 THERAPEUTICS. 5055 03:43:27,720 --> 03:43:30,320 SO HERE I'M OFFERING SOME 5056 03:43:30,320 --> 03:43:31,960 SPECIFIC AREAS OF INTEREST THAT 5057 03:43:31,960 --> 03:43:35,360 COULD FEED THE SCOPE OF THIS 5058 03:43:35,360 --> 03:43:35,640 CONCEPT. 5059 03:43:35,640 --> 03:43:38,600 WE CONTINUE TO ENCOURAGE 5060 03:43:38,600 --> 03:43:40,880 STUDYING THE EPIDEMIOLOGY AND 5061 03:43:40,880 --> 03:43:46,600 BIOLOGY OF ORAL HPV PERSISTENT 5062 03:43:46,600 --> 03:43:49,080 AND PROGRESSION IN PEOPLE WITH 5063 03:43:49,080 --> 03:43:49,360 HIV. 5064 03:43:49,360 --> 03:43:56,040 THE HIGH-RISK FACTORS SUCH AS 5065 03:43:56,040 --> 03:43:57,240 AGE, SOCIAL DETERMINATION AND 5066 03:43:57,240 --> 03:43:59,760 WHAT EFFECTS THIS VULNERABLE 5067 03:43:59,760 --> 03:44:00,120 POPULATION. 5068 03:44:00,120 --> 03:44:03,240 AND TO REITERATE THIS CONCEPT IS 5069 03:44:03,240 --> 03:44:05,400 FOCUSING ON THE MECHANISTIC 5070 03:44:05,400 --> 03:44:09,520 STUDIES INCLUDING STUDIES 5071 03:44:09,520 --> 03:44:11,760 EXPLORING THE EPIDEMIOLOGY AND 5072 03:44:11,760 --> 03:44:14,680 BIOLOGY FOR SYNERGISTIC 5073 03:44:14,680 --> 03:44:16,040 RELATIONSHIPS BETWEEN HIV AND 5074 03:44:16,040 --> 03:44:19,520 ORAL HPV INFECTIONS. 5075 03:44:19,520 --> 03:44:22,040 FOR EXAMPLE, IN STUDIES AND 5076 03:44:22,040 --> 03:44:24,440 ANIMAL STUDIES TO DETERMINE THE 5077 03:44:24,440 --> 03:44:32,360 THIS TWO VIRUSES AND STUDIES AND 5078 03:44:32,360 --> 03:44:35,560 AND ATTEND HIV INFECTION EFFECTS 5079 03:44:35,560 --> 03:44:39,640 ORAL HPV SUCH AS ORAL PROFILE 5080 03:44:39,640 --> 03:44:42,920 IMMUNOLOGY AND DYNAMIC 5081 03:44:42,920 --> 03:44:43,280 PATHOGENIC. 5082 03:44:43,280 --> 03:44:48,760 STUDIES EVALUATING THE IMPACT OF 5083 03:44:48,760 --> 03:44:51,400 ORAL MICRO BILE AND THE IMMUNE 5084 03:44:51,400 --> 03:44:52,600 PATHOGENIC CHANGES ASSOCIATED 5085 03:44:52,600 --> 03:44:55,640 WITH ORAL HPV ACQUISITION AND 5086 03:44:55,640 --> 03:44:58,240 PERSISTENCE AND PEOPLE WITH HIV. 5087 03:44:58,240 --> 03:45:01,080 AND LAST BUT NOT LEAST, STUDIES 5088 03:45:01,080 --> 03:45:11,440 AND COVERING THE PATHOGENESIS OF 5089 03:45:11,440 --> 03:45:12,520 ONCO-IMMUNOLOGY ON HOW 5090 03:45:12,520 --> 03:45:17,640 CONTRIBUTE TO THE INDUCTION OF 5091 03:45:17,640 --> 03:45:23,400 HPV-ASSOCIATED OROPHARYNGEAL 5092 03:45:23,400 --> 03:45:24,760 CANCER. 5093 03:45:24,760 --> 03:45:26,520 BIOMARKERS, MOLECULE DRIVERS AND 5094 03:45:26,520 --> 03:45:28,280 THE COMPONENTS AND PATHWAYS THAT 5095 03:45:28,280 --> 03:45:32,040 CONTRIBUTE TO THIS PATHOGENIC 5096 03:45:32,040 --> 03:45:32,440 PROGRESSION. 5097 03:45:32,440 --> 03:45:35,240 TO TAKE THE MESSAGE, I 5098 03:45:35,240 --> 03:45:38,080 APPRECIATE A COUNCIL'S DURATION 5099 03:45:38,080 --> 03:45:40,480 TO APPROVE THIS CONCEPT WHICH IS 5100 03:45:40,480 --> 03:45:43,360 TRYING TO ADDRESS AN IMPORTANT 5101 03:45:43,360 --> 03:45:45,640 PUBLIC-HEALTH AND CLINICAL 5102 03:45:45,640 --> 03:45:46,200 PROBLEM. 5103 03:45:46,200 --> 03:45:54,760 I JUST SINCERELY ACKNOWLE A ACKE 5104 03:45:54,760 --> 03:45:57,560 DOCTOR FOR THEIR VALUABLE TIME 5105 03:45:57,560 --> 03:45:58,560 ON THIS CONCEPT. 5106 03:45:58,560 --> 03:46:01,920 I'M TAKE QUESTIONS AND COMMENTS, 5107 03:46:01,920 --> 03:46:02,200 THANK YOU. 5108 03:46:02,200 --> 03:46:10,840 >> THANK YOU, AGAIN. 5109 03:46:10,840 --> 03:46:16,280 >> I CAN GET STARTED. 5110 03:46:16,280 --> 03:46:20,520 SO, I AM STRONG SUPPORT FOR THIS 5111 03:46:20,520 --> 03:46:20,920 CONCEPT. 5112 03:46:20,920 --> 03:46:25,480 WE'VE KNOWN FOR MANY YEARS THAT 5113 03:46:25,480 --> 03:46:28,320 PATIENTS WITH HIV HAVE INCREASES 5114 03:46:28,320 --> 03:46:31,040 FOR SARCOMA BUT AS PEOPLE WITH 5115 03:46:31,040 --> 03:46:36,040 HIV ARE LIVING MUCH LONGER NOW, 5116 03:46:36,040 --> 03:46:37,800 WITH THE SUCCESS OF THE THERAPY 5117 03:46:37,800 --> 03:46:40,640 WE'RE STARTING TOE SEE THAT THIS 5118 03:46:40,640 --> 03:46:42,120 PATIENTS ARE ALSO A LOT 5119 03:46:42,120 --> 03:46:46,640 INCREASED RISK FOR ORAL FAR 5120 03:46:46,640 --> 03:46:53,680 HANGAL CANCER WHICH HAS BEEN CA. 5121 03:46:53,680 --> 03:46:57,400 THE RELATIONSHIP WE KNOW HIV AND 5122 03:46:57,400 --> 03:47:00,120 HPV NEEDS TO BE MUCH BETTER 5123 03:47:00,120 --> 03:47:02,560 UNDERSTOOD IN ORDER FOR US TO 5124 03:47:02,560 --> 03:47:04,160 UNDERSTAND THE PATHOGENESIS OF 5125 03:47:04,160 --> 03:47:09,280 THIS DISEASE IN THIS PATIENTS 5126 03:47:09,280 --> 03:47:10,800 WITH HIV AND COME UP WITH A 5127 03:47:10,800 --> 03:47:15,120 BETTER PREVENTATIVE STRATEGIES 5128 03:47:15,120 --> 03:47:22,840 AND SO SHE DID A WONDERFUL JOB 5129 03:47:22,840 --> 03:47:26,200 PUTTING TOGETHER THESE CONCEPT 5130 03:47:26,200 --> 03:47:27,400 AND I THINK THIS IS SPECIFIC 5131 03:47:27,400 --> 03:47:32,080 AREAS OF INTEREST AND ARE 5132 03:47:32,080 --> 03:47:35,440 FOCUSED ON STUDIES THAT LOOK AT 5133 03:47:35,440 --> 03:47:43,080 BETWEEN THE TWO VIRUSES AND THIS 5134 03:47:43,080 --> 03:47:44,640 CAN BE IMPORTANT STUDIES FOR 5135 03:47:44,640 --> 03:47:47,840 THESE FIELD SO I THINK THAT THIS 5136 03:47:47,840 --> 03:47:51,640 IS A VERY TIMELY CONCEPT AND 5137 03:47:51,640 --> 03:47:53,480 HIGHLY SIGNIFICANT AND 5138 03:47:53,480 --> 03:47:54,800 ESPECIALLY IN LIGHT OF THE MANY, 5139 03:47:54,800 --> 03:47:58,800 MANY CASES THAT WE'VE SEEN OF 5140 03:47:58,800 --> 03:48:06,160 PATIENTS WITH ORROPHARYNGEAL 5141 03:48:06,160 --> 03:48:08,120 PATIENTS AND POSITIVE PATIENTS 5142 03:48:08,120 --> 03:48:10,200 WHO HAVE CANCER SO I STRONGLY 5143 03:48:10,200 --> 03:48:15,960 SUPPORT THIS CONCEPT. 5144 03:48:15,960 --> 03:48:16,360 >> THANK YOU. 5145 03:48:16,360 --> 03:48:18,480 >> I'M HAPPY TO GO NEXT AND ADD 5146 03:48:18,480 --> 03:48:20,520 MY SUPPORT AS WELL. 5147 03:48:20,520 --> 03:48:22,520 I MET WITH Dr. YIN AND I HAD A 5148 03:48:22,520 --> 03:48:25,280 NICE DISCUSSION ABOUT CONCEPT 5149 03:48:25,280 --> 03:48:30,600 CLEARANCE AND ENTHUSIASM FOR IT 5150 03:48:30,600 --> 03:48:32,560 BART BECAUSE IT'S ALIGNED WITH 5151 03:48:32,560 --> 03:48:33,080 NIH AND NIDCR. 5152 03:48:33,080 --> 03:48:34,640 THERE'S REALLY GOOD ALIGNMENT 5153 03:48:34,640 --> 03:48:38,920 WITH FISCAL YEAR 22 TO 25 FOR 5154 03:48:38,920 --> 03:48:40,720 HIV AND HIV RELATED RESEARCH AND 5155 03:48:40,720 --> 03:48:42,800 ONE GOAL THAT IS TO BETTER 5156 03:48:42,800 --> 03:48:45,600 UNDERSTAND ORAL HIV ASSOCIATED 5157 03:48:45,600 --> 03:48:46,480 CO MORBID TEASE AND CO 5158 03:48:46,480 --> 03:48:48,200 INFECTIONS AND COMPUTATIONS AND 5159 03:48:48,200 --> 03:48:49,880 THIS IS VERY WELL RIGHT IN THE 5160 03:48:49,880 --> 03:48:52,040 MIDDLE OF THAT AND ALSO EVEN 5161 03:48:52,040 --> 03:48:54,520 MORE ALIGNED WITH THE NIDCR 5162 03:48:54,520 --> 03:48:55,880 STRATEGIC PLAN AND INITIATIVES 5163 03:48:55,880 --> 03:48:57,680 TO INTEGRATE ORAL AND GENERAL 5164 03:48:57,680 --> 03:48:59,600 HEALTH SO WE HEARD A LOT ABOUT 5165 03:48:59,600 --> 03:49:01,840 THAT JUST RECENTLY AND THIS IS 5166 03:49:01,840 --> 03:49:03,720 REALLY WELL PLACED IN THE MIDDLE 5167 03:49:03,720 --> 03:49:07,840 OF THE INITIATIVE THAT BRUCE 5168 03:49:07,840 --> 03:49:09,240 DONOFF JUST TOLD US ABOUT AND IT 5169 03:49:09,240 --> 03:49:13,120 PUTS THE MOUTH BACK IN THE BODY, 5170 03:49:13,120 --> 03:49:13,320 RIGHT. 5171 03:49:13,320 --> 03:49:16,400 THIS IS CENTRAL IN A REALLY 5172 03:49:16,400 --> 03:49:17,000 COMPLICATED DIAGRAM WHERE YOU 5173 03:49:17,000 --> 03:49:19,440 HAVE ORAL HEALTH, VIROLOGY, 5174 03:49:19,440 --> 03:49:21,200 EPIDEMIOLOGY, CANCER, 5175 03:49:21,200 --> 03:49:23,440 POTENTIALLY IMMUNOTHERAPIES AND 5176 03:49:23,440 --> 03:49:24,080 VACCINES, MICROBIOME RESEARCH 5177 03:49:24,080 --> 03:49:26,400 AND IT REALLY SITS IN THE MIDDLE 5178 03:49:26,400 --> 03:49:29,920 OF IS THAT DENTAL AND GENERAL 5179 03:49:29,920 --> 03:49:30,160 HEALTH. 5180 03:49:30,160 --> 03:49:31,360 IT CAN LEAD TO OPPORTUNITIES 5181 03:49:31,360 --> 03:49:33,680 WITH NCI TO DEVELOP 5182 03:49:33,680 --> 03:49:34,480 MULTI-DISCIPLINARY RESEARCH 5183 03:49:34,480 --> 03:49:37,600 AREAS AND SO I THINK MUCH CAN BE 5184 03:49:37,600 --> 03:49:40,920 BUILT FROM THIS CONCEPT. 5185 03:49:40,920 --> 03:49:42,360 THERE'S GREAT BUILDING ON COUPLE 5186 03:49:42,360 --> 03:49:45,320 OF RECENT RFAs AND THEY WERE 5187 03:49:45,320 --> 03:49:47,320 MORE FOCUSED AND REALLY JUST 5188 03:49:47,320 --> 03:49:48,840 TOUCHED ON THE FIRST BULLET 5189 03:49:48,840 --> 03:49:50,520 POINT HERE ON THE SLIDE THAT IS 5190 03:49:50,520 --> 03:49:53,400 STILL UP, STUDYING THE 5191 03:49:53,400 --> 03:49:55,400 EPIDEMIOLOGY AND BIOLOGY OF 5192 03:49:55,400 --> 03:49:56,920 PERSISTENT AND PROGRESSION AND 5193 03:49:56,920 --> 03:50:00,040 PEOPLE WITH HIV AND THE CONCEPT 5194 03:50:00,040 --> 03:50:03,920 GOES ON MUCH PAST THAT IMPACT OF 5195 03:50:03,920 --> 03:50:06,280 ANTI-RETRO FIE RAL THERAPY, 5196 03:50:06,280 --> 03:50:07,680 MECHANISMS OF HOW HIV INFECTION 5197 03:50:07,680 --> 03:50:10,400 CAN CHANGE AND ASPECTS AND HOW 5198 03:50:10,400 --> 03:50:12,760 MICROBIOME FEEDS INTO THAT AND 5199 03:50:12,760 --> 03:50:15,000 IMMUNO LOGIC CHANGES AND 5200 03:50:15,000 --> 03:50:16,840 EPIDEMIOLOGY AND MORE MECHANISMS 5201 03:50:16,840 --> 03:50:19,360 AND SO I THINK IT'S REALLY 5202 03:50:19,360 --> 03:50:22,960 EXCEEDINGLY WELL POSITIONED 5203 03:50:22,960 --> 03:50:23,440 STRATEGICALLY. 5204 03:50:23,440 --> 03:50:25,400 IN OUR DISCUSSION WE TALKED 5205 03:50:25,400 --> 03:50:28,200 ABOUT A COUPLE OF OTHER ISSUES 5206 03:50:28,200 --> 03:50:31,640 OR RECOMMENDATIONS TO MAYBE 5207 03:50:31,640 --> 03:50:32,800 TWEAK THIS AND ONE SO THE 5208 03:50:32,800 --> 03:50:34,320 RESPONSE TO THE PREVIOUS RFAs 5209 03:50:34,320 --> 03:50:36,560 ARE REALLY, REALLY, AS I 5210 03:50:36,560 --> 03:50:38,080 UNDERSTAND, MIKE OWE BIOME 5211 03:50:38,080 --> 03:50:40,600 FOCUSED AND WHILE MICROBIOME IS 5212 03:50:40,600 --> 03:50:42,000 ESSENTIAL TO THESE KINDS OF 5213 03:50:42,000 --> 03:50:43,440 RESEARCH QUESTIONS, WE WANTED TO 5214 03:50:43,440 --> 03:50:45,720 DO WHAT WE CAN TO MAKE SURE THAT 5215 03:50:45,720 --> 03:50:48,120 IT IS NOT -- IT SUCKS ALL THE 5216 03:50:48,120 --> 03:50:48,600 ATTENTION. 5217 03:50:48,600 --> 03:50:50,120 THERE ARE SO MANY OTHER ASPECTS 5218 03:50:50,120 --> 03:50:54,360 OF IMMUNOLOGY, THAT WE HOPE WE 5219 03:50:54,360 --> 03:50:57,440 CAN SORT OF MAKE SURE TO GET 5220 03:50:57,440 --> 03:50:59,080 ATTENTION AS WELL AS THE 5221 03:50:59,080 --> 03:51:09,440 MICROBIOME ASPECTS. 5222 03:51:10,040 --> 03:51:11,880 >> ONE PRIORITY WAS WE WANT TO 5223 03:51:11,880 --> 03:51:16,920 MAKE SURE THAT THE CONCEPT 5224 03:51:16,920 --> 03:51:18,560 CENTERS POPULATIONS THAT ARE 5225 03:51:18,560 --> 03:51:19,920 SPECIFICALLY VULNERABLE AND WE 5226 03:51:19,920 --> 03:51:21,680 WANT TO MAKE SURE THAT 5227 03:51:21,680 --> 03:51:24,600 SITUATIONS LIKE NURSING MOTHERS, 5228 03:51:24,600 --> 03:51:27,800 THE LGBTQIA PLUS COMMUNITY, 5229 03:51:27,800 --> 03:51:29,560 RECEIVE PARTICULAR ATTENTION 5230 03:51:29,560 --> 03:51:31,080 BECAUSE THOSE ARE THE MOST 5231 03:51:31,080 --> 03:51:32,560 VULNERABLE POPULATIONS AND THESE 5232 03:51:32,560 --> 03:51:34,560 CO INFECTIONS SITUATIONS AND 5233 03:51:34,560 --> 03:51:36,800 LASTLY, I'M . ENGINEER AND A 5234 03:51:36,800 --> 03:51:39,520 TECHNOLOGY DEVELOPER SO, YOU 5235 03:51:39,520 --> 03:51:41,320 KNOW, IT SORT OF WAS NATURAL FOR 5236 03:51:41,320 --> 03:51:44,040 ME TO WONDER HOW THIS MIGHT LEAD 5237 03:51:44,040 --> 03:51:46,440 TO IMMUNOTHERAPY DESIGN OR EVEN 5238 03:51:46,440 --> 03:51:47,840 DIAGNOSTIC DESIGN FOR CO 5239 03:51:47,840 --> 03:51:50,520 INFECTION SITUATIONS AND IT 5240 03:51:50,520 --> 03:51:52,720 SEEMS LIKE THIS SHOULD BE 5241 03:51:52,720 --> 03:51:53,880 POSITIONED CAREFULLY WITH 5242 03:51:53,880 --> 03:51:55,400 RESPECT TO IMMUNOTHERAPY 5243 03:51:55,400 --> 03:51:58,040 DEVELOPMENT AT NCI AND 5244 03:51:58,040 --> 03:52:01,360 HOPEFULLY, COLLABORATIVELY WITH 5245 03:52:01,360 --> 03:52:03,800 NCI SO THAT THE PATH TOWARDS 5246 03:52:03,800 --> 03:52:06,000 ACTUAL ADDRESSING IS CO 5247 03:52:06,000 --> 03:52:08,400 INFECTIONS AND CAN BE MORE 5248 03:52:08,400 --> 03:52:14,200 CLEARLY SORT OF MAPPED OUT. 5249 03:52:14,200 --> 03:52:16,840 SO BECAUSE IT'S SO STRATEGICALLY 5250 03:52:16,840 --> 03:52:18,880 POSITIONED WELL WITHIN IMPORTANT 5251 03:52:18,880 --> 03:52:26,080 INITIATIVES FOR NIH AND NIDCR. 5252 03:52:26,080 --> 03:52:29,160 >> I GROW WITH MY COLLEAGUES. 5253 03:52:29,160 --> 03:52:32,400 THIS IS A VERY TIMELY CONCEPT 5254 03:52:32,400 --> 03:52:34,360 AND IT WAS VERY LOGIC AND THE 5255 03:52:34,360 --> 03:52:36,920 BEAUTY AND THE EPIDEMIOLOGY DATA 5256 03:52:36,920 --> 03:52:38,560 AND NOW GUIDING THE PEOPLE GOING 5257 03:52:38,560 --> 03:52:41,960 TO THE MECHANISTIC STUDY WHICH 5258 03:52:41,960 --> 03:52:43,520 WOULD LEAD TO THE DIAGNOSTIC AND 5259 03:52:43,520 --> 03:52:46,600 THE THERAPEUTIC TOOLS. 5260 03:52:46,600 --> 03:52:48,440 SO, I HAVE NOTHING MORE TO 5261 03:52:48,440 --> 03:52:51,440 ADJUST SAYING THAT THIS IS 5262 03:52:51,440 --> 03:52:53,680 SUPPORTED AND Dr. YIN DID A 5263 03:52:53,680 --> 03:53:01,720 GREAT JOB TO PUT THIS CONCEPT 5264 03:53:01,720 --> 03:53:01,960 TOGETHER. 5265 03:53:01,960 --> 03:53:02,600 >> Lynn M. King: ARE THERE ANY 5266 03:53:02,600 --> 03:53:13,080 OTHER COMMENTS OR QUESTIONS? 5267 03:53:16,480 --> 03:53:17,920 IF NOT, WOULD A MEMBER OF 5268 03:53:17,920 --> 03:53:19,320 COUNCIL LIKE TO MAKE A MOTION 5269 03:53:19,320 --> 03:53:20,840 FOR RECOMMENDATIONS TO APPROVE 5270 03:53:20,840 --> 03:53:23,080 THIS CONCEPT? 5271 03:53:23,080 --> 03:53:27,480 >> SO MOVED, JACK. 5272 03:53:27,480 --> 03:53:32,960 >> SECOND. 5273 03:53:32,960 --> 03:53:33,240 WEN CHIEF. 5274 03:53:33,240 --> 03:53:36,920 >>.>> AYE. 5275 03:53:36,920 --> 03:53:38,760 >> ANY OPPOSED? 5276 03:53:38,760 --> 03:53:42,480 >> OK. 5277 03:53:42,480 --> 03:53:42,960 THANK YOU. 5278 03:53:42,960 --> 03:53:45,720 >> THANK YOU SO MUCH FOR YOUR 5279 03:53:45,720 --> 03:53:45,960 SUPPORT. 5280 03:53:45,960 --> 03:53:49,520 I REALLY APPRECIATE IT. 5281 03:53:49,520 --> 03:53:50,800 >> Lynn M. King: THANK YOU. 5282 03:53:50,800 --> 03:53:52,560 NEXT TWO CONCEPTS WILL BE 5283 03:53:52,560 --> 03:53:58,480 PRESENTED BY Dr. PREETHI 5284 03:53:58,480 --> 03:54:00,120 CHANDER FROM IMMUNOLOGY PROGRAM 5285 03:54:00,120 --> 03:54:03,760 AND THE FIRST CONCEPT WILL BE 5286 03:54:03,760 --> 03:54:08,040 LED BY REVIEWERS Dr. NOR AND 5287 03:54:08,040 --> 03:54:10,160 CHI AND GO AHEAD AND BEGIN WITH 5288 03:54:10,160 --> 03:54:13,680 YOUR FIRST CONCEPT, CHRONIC 5289 03:54:13,680 --> 03:54:24,200 INFLAMMATION OF THE ORAL CAVITY. 5290 03:54:58,360 --> 03:54:58,960 >> Lynn M. King: WE HAVE THE 5291 03:54:58,960 --> 03:55:00,440 NEXT CONCEPT READY? 5292 03:55:00,440 --> 03:55:10,840 CHRONIC INFLAMMATION? 5293 03:55:17,360 --> 03:55:18,120 >> THANK YOU. 5294 03:55:18,120 --> 03:55:20,760 GOOD AFTERNOON, EVERYBODY. 5295 03:55:20,760 --> 03:55:24,120 I AM PROGRAM OFFICER FOR THE 5296 03:55:24,120 --> 03:55:26,080 NIDCR BIOLOGY AND IMMUNOLOGY 5297 03:55:26,080 --> 03:55:27,520 PROGRAM AND I'M HERE TODAY ALONG 5298 03:55:27,520 --> 03:55:30,360 WITH MY COLLEAGUE Dr. MCNEIL' 5299 03:55:30,360 --> 03:55:33,040 THE PROGRAM OFFICER FOR THE 5300 03:55:33,040 --> 03:55:35,680 NIDCR ORAL MICRO AND BACTERIAL 5301 03:55:35,680 --> 03:55:36,440 DISEASES PROGRAM. 5302 03:55:36,440 --> 03:55:38,040 WE WOULD LIKE TO THANK YOU ALL 5303 03:55:38,040 --> 03:55:39,960 FOR THE OPPORTUNITY TO PRESENT 5304 03:55:39,960 --> 03:55:42,000 THIS AND SEEK COUNCIL 5305 03:55:42,000 --> 03:55:44,560 CONCURRENCE ON THE CONCEPT. 5306 03:55:44,560 --> 03:55:46,520 CHRONIC INFLAMMATION OF THE ORAL 5307 03:55:46,520 --> 03:55:52,360 CAVITY AN AGENT FOR ORAL MUCOSAL 5308 03:55:52,360 --> 03:55:52,760 DISEASE. 5309 03:55:52,760 --> 03:55:54,880 SO THE GOAL OF THIS CONCEPT IS 5310 03:55:54,880 --> 03:55:56,280 TO INVESTIGATE THE MECHANISMS 5311 03:55:56,280 --> 03:55:58,400 ARE CHRONIC INFLAMMATION AS THEY 5312 03:55:58,400 --> 03:56:01,360 RELATE TO THE ORAL ENVIRONMENT. 5313 03:56:01,360 --> 03:56:03,360 INCLUDING ORAL MANIFESTATIONS OF 5314 03:56:03,360 --> 03:56:06,200 CHRONIC SYSTEMIC DISEASES. 5315 03:56:06,200 --> 03:56:09,240 IT'S CLEAR FROM RESEARCH THAT 5316 03:56:09,240 --> 03:56:11,120 BOTH PETS OWE AGAINST IN ORAL 5317 03:56:11,120 --> 03:56:12,080 CAVITY PLAY A ROLE IN THE 5318 03:56:12,080 --> 03:56:15,080 DEVELOPMENT OF INFLAMMATION AND 5319 03:56:15,080 --> 03:56:17,520 THAT ALSO ALTERED THE 5320 03:56:17,520 --> 03:56:19,320 INFLAMMATION STATE LEADING TO 5321 03:56:19,320 --> 03:56:21,800 YET OTHER CONDITIONS IN THE 5322 03:56:21,800 --> 03:56:22,600 MOUTH. 5323 03:56:22,600 --> 03:56:24,560 HOWEVER, THE MECHANISMS BY WHICH 5324 03:56:24,560 --> 03:56:27,160 THIS HEIGHTENED STATE PRIMES THE 5325 03:56:27,160 --> 03:56:29,520 IMMUNE MEMORY AND THEN EFFECTS 5326 03:56:29,520 --> 03:56:34,280 THE ONSET AND PROGRESS OF 5327 03:56:34,280 --> 03:56:37,800 MUCOSAL DISEASE OF THE ORAL 5328 03:56:37,800 --> 03:56:38,640 CAVITY IS LESS CLEAR. 5329 03:56:38,640 --> 03:56:41,280 THE RESULTS OF THIS INITIATIVE 5330 03:56:41,280 --> 03:56:42,400 WILL DRIVE OUR UNDERSTANDING OF 5331 03:56:42,400 --> 03:56:44,440 THE COMPLEX PHENOMENON AND SET 5332 03:56:44,440 --> 03:56:47,080 THE STAGE FOR EFFORTS LEADING TO 5333 03:56:47,080 --> 03:56:50,280 PREVENTION OF ONSET OF CONNICK 5334 03:56:50,280 --> 03:56:51,520 INFLAMMATION IN CONDITIONS FOR 5335 03:56:51,520 --> 03:56:54,400 EXAMPLE LIKE CANCER, AUTO UM 5336 03:56:54,400 --> 03:56:59,280 UNITY AN MUCOSAL DISEASE AND 5337 03:56:59,280 --> 03:57:00,680 DISEASES OF THE ORAL CAVITY. 5338 03:57:00,680 --> 03:57:02,680 I WANT TO MAKE CLEAR THAT THIS 5339 03:57:02,680 --> 03:57:05,320 INITIATIVE IS NOT FOCUSED ON THE 5340 03:57:05,320 --> 03:57:09,360 DEVELOPMENT OF A TRANSITION TO 5341 03:57:09,360 --> 03:57:11,160 DIS PIOSIS OR DIE BIOTICS 5342 03:57:11,160 --> 03:57:12,080 COMMUNITIES BUT THE FOCUS IS 5343 03:57:12,080 --> 03:57:14,320 HERE USING CHRONIC INFLAMMATION 5344 03:57:14,320 --> 03:57:17,520 OF THE STARTLING POINT AND THEN 5345 03:57:17,520 --> 03:57:18,400 GOING ONWARDS TO THE OTHER 5346 03:57:18,400 --> 03:57:19,920 CONDITIONS THAT EFFECT THE ORAL 5347 03:57:19,920 --> 03:57:22,840 CAVITY AND TO UNDERSTAND THE 5348 03:57:22,840 --> 03:57:23,280 MECHANISMS. 5349 03:57:23,280 --> 03:57:27,240 NEXT SLIDE, PLEASE. 5350 03:57:27,240 --> 03:57:29,640 A COMBINATION OF WHO EXISTS IN 5351 03:57:29,640 --> 03:57:32,560 THE MICROBIOME, THE ENVIRONMENT, 5352 03:57:32,560 --> 03:57:35,920 BOTH THE HOST AND THE EXTERNAL, 5353 03:57:35,920 --> 03:57:39,080 AND THE HOST PLAY A ROLE IN 5354 03:57:39,080 --> 03:57:41,000 MAINTAINING HEALTH OF ORAL 5355 03:57:41,000 --> 03:57:41,600 CAVITY. 5356 03:57:41,600 --> 03:57:43,400 DISRUPTIONS IN ANY OF THESE MAY 5357 03:57:43,400 --> 03:57:45,640 LEAD TO THE INFLAMMATION STATE 5358 03:57:45,640 --> 03:57:47,760 WHICH IS IF UNCONTROLLED MAY BE 5359 03:57:47,760 --> 03:57:49,520 CHRONIC AND LEAD TO THE CONCEPT 5360 03:57:49,520 --> 03:57:52,880 AND PROGRESSION OF OTHER ORAL 5361 03:57:52,880 --> 03:57:53,120 DISEASES. 5362 03:57:53,120 --> 03:57:55,480 SO THIS INITIATIVE SEEKS TO 5363 03:57:55,480 --> 03:57:56,880 EXPAND OUR KNOWLEDGE ON THE ROLE 5364 03:57:56,880 --> 03:57:59,200 OF THIS EARLY CHRONIC 5365 03:57:59,200 --> 03:58:00,600 INFLAMMATORY STATE OF THE ORAL 5366 03:58:00,600 --> 03:58:02,520 CAVITY AND HOW IT RELATES TO THE 5367 03:58:02,520 --> 03:58:04,080 ON GOING AND PROGRESSION OF 5368 03:58:04,080 --> 03:58:06,920 OTHER ORAL DISEASES. 5369 03:58:06,920 --> 03:58:09,360 FOR EXAMPLE, IT'S NOW ACCEPTED 5370 03:58:09,360 --> 03:58:11,400 THAT SHIFTS IN MICROBIOME 5371 03:58:11,400 --> 03:58:14,720 INDUCED BY INFLAMMATION, FEVER 5372 03:58:14,720 --> 03:58:16,560 OVER GROWTH OF COMMON CELLS 5373 03:58:16,560 --> 03:58:19,160 ALTERATION AND EXPRESSION OF 5374 03:58:19,160 --> 03:58:20,600 FACTORS AND THESE MAY LEAD TO 5375 03:58:20,600 --> 03:58:22,840 CONDITIONS SUCH AS ORAL CANCER 5376 03:58:22,840 --> 03:58:30,680 AND LEADING TO VARIOUS OTHER 5377 03:58:30,680 --> 03:58:31,240 CONDITIONS. 5378 03:58:31,240 --> 03:58:33,720 GIVEN THIS, WE CAN SEE A NUMBER 5379 03:58:33,720 --> 03:58:35,160 OF OPPORTUNITIES AND SOME OF 5380 03:58:35,160 --> 03:58:37,520 THESE BUT NOT ALL ARE LISTED 5381 03:58:37,520 --> 03:58:37,840 HERE. 5382 03:58:37,840 --> 03:58:40,480 THE ROLE OF ORAL CHRONIC 5383 03:58:40,480 --> 03:58:42,440 INFLAMMATION I AM POST WORLD 5384 03:58:42,440 --> 03:58:44,760 CONDITIONS SUCH AS HIGHLIGHTED 5385 03:58:44,760 --> 03:58:46,320 BY THE PANDEMIC AND IS SEEN IN 5386 03:58:46,320 --> 03:58:48,280 THE CASE OF LONG COVID. 5387 03:58:48,280 --> 03:58:50,840 AND ALSO THE ROLE OF VARIOUS 5388 03:58:50,840 --> 03:58:52,440 VIRUSES LIKE EPSTEIN BAR VIRUS 5389 03:58:52,440 --> 03:58:54,200 AND THE PRESENCE IN THE SALIVARY 5390 03:58:54,200 --> 03:58:55,600 GRAND AND OTHER IMMUNE ISSUES 5391 03:58:55,600 --> 03:58:57,480 HAVE HIGHLIGHTED SOME OF THE 5392 03:58:57,480 --> 03:58:59,600 ROLES THAT EARLY INFLAMMATION 5393 03:58:59,600 --> 03:59:01,480 SETS THE STAGE FOR. 5394 03:59:01,480 --> 03:59:03,640 AND INFLAMMATION, ALTHOUGH 5395 03:59:03,640 --> 03:59:06,040 SUSPECTED TO PLAY A ROLE IN 5396 03:59:06,040 --> 03:59:09,680 PATHOGEN OF CANCER, ALSO EFFECTS 5397 03:59:09,680 --> 03:59:13,080 ON COMMON CELLS WHICH THEN DO 5398 03:59:13,080 --> 03:59:14,760 INFLUENCE OF ORAL CANCER 5399 03:59:14,760 --> 03:59:15,720 DEVELOPMENT AND PROGRESSION AND 5400 03:59:15,720 --> 03:59:17,960 MUCH NEEDS TO BE UNDERSTAND 5401 03:59:17,960 --> 03:59:19,760 GUIDING THE AK IS BETWEEN THE 5402 03:59:19,760 --> 03:59:21,400 HIKE ROW BIOME, THE IMMUNE 5403 03:59:21,400 --> 03:59:25,040 REACTIONS AND CANCER. 5404 03:59:25,040 --> 03:59:27,040 MOST MICROBIOME INTERACTIONS 5405 03:59:27,040 --> 03:59:28,720 WITH CHRONIC INFLAMMATION MAY 5406 03:59:28,720 --> 03:59:31,680 ALSO LEAD TO OTHER REACTIVITY. 5407 03:59:31,680 --> 03:59:34,640 ACTIVATING MECHANISMS SUCH AS 5408 03:59:34,640 --> 03:59:40,080 SMALL MIMIC REAND EPITOPES AND 5409 03:59:40,080 --> 03:59:41,920 INFECTED B CELLS THAT CAN LEN 5410 03:59:41,920 --> 03:59:45,280 THEY HAD TO AUTOIMMUNE RELATED 5411 03:59:45,280 --> 03:59:45,880 ILLNESSES. 5412 03:59:45,880 --> 03:59:47,080 I FOCUS ON CONTROLLING OR 5413 03:59:47,080 --> 03:59:48,560 PREVENTING CHRONIC INFLAMMATION 5414 03:59:48,560 --> 03:59:51,960 MAY LEAD TO NEW IDEAS TO PREVENT 5415 03:59:51,960 --> 03:59:53,760 FUNCTIONAL END POINTS RESULT 5416 03:59:53,760 --> 03:59:56,200 INTERESTING SUCH A STATE. 5417 03:59:56,200 --> 03:59:58,360 THIS INITIATIVE PROVIDES THE 5418 03:59:58,360 --> 04:00:00,400 OPPORTUNITY FOR A DEEPER 5419 04:00:00,400 --> 04:00:02,160 EXPLORATION OF THE SPECIFIC ORAL 5420 04:00:02,160 --> 04:00:04,280 MAN PHYSICALTATIONS OF 5421 04:00:04,280 --> 04:00:07,240 INFLAMMATION OF SOME CONDITIONS 5422 04:00:07,240 --> 04:00:14,440 LIKE ORAL LICHEN PLANUS AND 5423 04:00:14,440 --> 04:00:16,200 BULLOUS AND THIS IS ACROSS 5424 04:00:16,200 --> 04:00:17,520 DISCIPLINES TO MOVE THIS FIELD 5425 04:00:17,520 --> 04:00:19,120 TO OUR UNDERSTANDING OF THE ROLE 5426 04:00:19,120 --> 04:00:22,960 OF CHRONIC INFLAMMATION THAT IS 5427 04:00:22,960 --> 04:00:25,040 PLAYING AND OTHER CONDITIONS AS 5428 04:00:25,040 --> 04:00:27,800 THEY RELATE TO THE ORAL CAVITY. 5429 04:00:27,800 --> 04:00:30,840 THE OUTCOMES ARE HOPED TO LEAD 5430 04:00:30,840 --> 04:00:32,440 THERAPEUTIC STRATEGIES THAT THEN 5431 04:00:32,440 --> 04:00:35,840 ALLOW FOR ADDRESSING THIS STATE 5432 04:00:35,840 --> 04:00:38,080 OF THE MOUTH. 5433 04:00:38,080 --> 04:00:39,920 WITH THAT I WILL STOP, TAKE 5434 04:00:39,920 --> 04:00:41,480 QUESTIONS AND THANK THE 5435 04:00:41,480 --> 04:00:43,160 REVIEWERS Dr. NOR AND SHE AND 5436 04:00:43,160 --> 04:00:44,520 TURN IT OVER TO THEM AND I 5437 04:00:44,520 --> 04:00:48,760 BELIEVE Dr. NOR IS GOING 5438 04:00:48,760 --> 04:00:48,960 FIRST. 5439 04:00:48,960 --> 04:00:49,760 THANK YOU. 5440 04:00:49,760 --> 04:00:53,640 >> THANK YOU, Dr. CHANDER. 5441 04:00:53,640 --> 04:00:55,720 IT WAS A GREAT SUMMARY OF THIS 5442 04:00:55,720 --> 04:00:56,360 CONCEPT. 5443 04:00:56,360 --> 04:00:58,920 SO WE KNOW FOR A LONG TIME THAT 5444 04:00:58,920 --> 04:01:00,920 THE CHRONIC INFLAMMATION IN THE 5445 04:01:00,920 --> 04:01:05,640 ORAL CAVITY IS ASSOCIATED WITH 5446 04:01:05,640 --> 04:01:08,440 ORAL CONDITIONS, ORAL DISEASE 5447 04:01:08,440 --> 04:01:10,000 AND ORAL CANCER IS ONE OF THEM 5448 04:01:10,000 --> 04:01:14,080 BUT THERE ARE MANY OTHERS SO FOR 5449 04:01:14,080 --> 04:01:19,040 EXAMPLE, WE CAN PLAN Dr. CHA 5450 04:01:19,040 --> 04:01:20,080 CHANDER MENTIONED. 5451 04:01:20,080 --> 04:01:23,120 MANY OF THESE STUDIES HAVE BEEN 5452 04:01:23,120 --> 04:01:25,600 ASSOCIATION STUDIES. 5453 04:01:25,600 --> 04:01:29,240 IT REALLY HAVEN'T DIG VERY DEEP 5454 04:01:29,240 --> 04:01:32,280 IN TERMS OF MECHANISMS 5455 04:01:32,280 --> 04:01:33,040 UNDERLYING THIS ASSOCIATION. 5456 04:01:33,040 --> 04:01:34,840 WHAT I LIKE ABOUT THIS CONCEPT 5457 04:01:34,840 --> 04:01:36,720 HERE IS THAT IT'S REALLY 5458 04:01:36,720 --> 04:01:45,160 FOCUSING ON MECHANISTIC STUDIES 5459 04:01:45,160 --> 04:01:46,480 LOOKING HOW IT CAN CAUSE OR 5460 04:01:46,480 --> 04:01:49,520 PROMOTE THE PROGRESSION OF ORAL 5461 04:01:49,520 --> 04:01:49,800 DISEASES. 5462 04:01:49,800 --> 04:01:52,480 SO THIS I BELIEVE IS AN 5463 04:01:52,480 --> 04:01:56,080 IMPORTANT GAP OF KNOWLEDGE THAT 5464 04:01:56,080 --> 04:01:59,120 THIS CONCEPT IS ADDRESSING. 5465 04:01:59,120 --> 04:02:00,920 AND ALSO WHAT I BELIEVE IS 5466 04:02:00,920 --> 04:02:06,040 IMPORTANT HERE IS THE SPECIFIC 5467 04:02:06,040 --> 04:02:09,760 AREAS OF INTEREST, THAT ARE IN 5468 04:02:09,760 --> 04:02:12,520 THIS SLIDE THAT IS STILL PRESENT 5469 04:02:12,520 --> 04:02:18,640 HERE WITH US AND IT IS -- THIS 5470 04:02:18,640 --> 04:02:25,120 FOCUS ALSO ON ONLY MECHANISM BUT 5471 04:02:25,120 --> 04:02:32,120 A LARGER CONDITIONS THAT PREVENT 5472 04:02:32,120 --> 04:02:32,840 THIS PROCESS. 5473 04:02:32,840 --> 04:02:40,040 I CONSIDER THIS CONCEPT VERY 5474 04:02:40,040 --> 04:02:44,800 SIGNIFICANT IT TRANCATIONAL 5475 04:02:44,800 --> 04:02:49,840 STUDIES THAT CENTRAL GEEZ AND AS 5476 04:02:49,840 --> 04:02:54,440 SUCH I SUPPORT THIS CONCEPT. 5477 04:02:54,440 --> 04:02:58,920 THANK YOU. 5478 04:02:58,920 --> 04:03:00,680 >> YEAH. 5479 04:03:00,680 --> 04:03:03,720 SO, I'M TOTALLY SUPPORTIVE OF 5480 04:03:03,720 --> 04:03:06,520 THIS CONCEPT AS WELL AND VERY 5481 04:03:06,520 --> 04:03:07,960 EXCITING AND I WOULDN'T REPEAT 5482 04:03:07,960 --> 04:03:10,200 ALL OF THE GOOD THINGS ALREADY 5483 04:03:10,200 --> 04:03:12,120 TALKING ABOUT. 5484 04:03:12,120 --> 04:03:14,000 THE ONLY THING OF SOME OF THE 5485 04:03:14,000 --> 04:03:16,600 CONCERNS DURING THE DISCUSSION 5486 04:03:16,600 --> 04:03:20,960 IS THIS IS A TOPIC THAT WE BE 5487 04:03:20,960 --> 04:03:22,760 INVESTING IN FOR A LONG TIME, I 5488 04:03:22,760 --> 04:03:24,640 WANT TO MAKE SURE WHEN THEY 5489 04:03:24,640 --> 04:03:26,680 RESPOND TO THE CONCEPT THAT IT'S 5490 04:03:26,680 --> 04:03:29,040 NOT GOING TO BE IN A BUSINESS AS 5491 04:03:29,040 --> 04:03:30,640 USUAL AND IT'S STILL DOING A LOT 5492 04:03:30,640 --> 04:03:41,000 OF CORRELATION STUDY. 5493 04:03:48,280 --> 04:03:49,960 >> THE TOPIC IS BIG AND HOW DO 5494 04:03:49,960 --> 04:03:55,360 WE MAKE A QUANTUM LEAP INSTEAD 5495 04:03:55,360 --> 04:03:57,120 OF SOME SMALL INCREMENTAL 5496 04:03:57,120 --> 04:03:59,800 CHANGES AND THOSE ARE SOME OF 5497 04:03:59,800 --> 04:04:01,040 THE CONCERNS THAT WE DISCUSSED 5498 04:04:01,040 --> 04:04:05,120 BUT OVER ALL THIS IS A GREAT 5499 04:04:05,120 --> 04:04:07,440 CONCEPT AND MANY UNSOLVED 5500 04:04:07,440 --> 04:04:09,560 PROBLEMS SO WE'RE SUPPORTIVE OF 5501 04:04:09,560 --> 04:04:14,360 THIS CONCEPT. 5502 04:04:14,360 --> 04:04:15,120 >> THANK YOU. 5503 04:04:15,120 --> 04:04:16,720 >> ANY OTHER COMMENTS OR 5504 04:04:16,720 --> 04:04:20,040 QUESTIONS ABOUT THIS CONCEPT? 5505 04:04:20,040 --> 04:04:22,640 >> I HAVE ONE QUICK QUESTION. 5506 04:04:22,640 --> 04:04:27,320 I DON'T FULLY UNDERSTAND THE 5507 04:04:27,320 --> 04:04:31,560 EXCLUSION THAT I REFERRED TO OF 5508 04:04:31,560 --> 04:04:32,880 INFECTION-RELATED INFLAMMATION 5509 04:04:32,880 --> 04:04:34,440 AND MAYBE IT JUST NEEDS TO BE 5510 04:04:34,440 --> 04:04:36,800 WORDED A LITTLE DIFFERENT TEE? 5511 04:04:36,800 --> 04:04:38,080 >> GOOD POINT. 5512 04:04:38,080 --> 04:04:39,520 I WILL MAKE A NOTE OF THAT. 5513 04:04:39,520 --> 04:04:41,720 BUT I THINK THAT THE REAL POINT 5514 04:04:41,720 --> 04:04:43,800 WAS THAT, LIKE Dr. SHE SAID, 5515 04:04:43,800 --> 04:04:46,160 WE'VE HAD A LOT OF ASSOCIATED 5516 04:04:46,160 --> 04:04:50,680 STUD SKIS WHE'S WHERE WE'VE SEEY 5517 04:04:50,680 --> 04:04:52,600 CHANGE IN MICROBIOME BUT HERE WE 5518 04:04:52,600 --> 04:04:57,000 LOCK AT THE FUNCTIONAL EFFECTS 5519 04:04:57,000 --> 04:04:58,400 OF THAT THAT EFFECT WE SEEN. 5520 04:04:58,400 --> 04:05:02,520 WE WANT THE FOCUS TO STAY ON THE 5521 04:05:02,520 --> 04:05:04,520 FUNCTIONALITY AND WHAT ACTUALLY 5522 04:05:04,520 --> 04:05:08,080 IS THE EFFECT THAT SHIFTS THE 5523 04:05:08,080 --> 04:05:09,880 HOMEOSTATIC CONDITION OF THE 5524 04:05:09,880 --> 04:05:11,720 MOUTH TOWARDS SOME MORE DISEASE 5525 04:05:11,720 --> 04:05:13,360 STATE AND HOW THOSE CAN BE 5526 04:05:13,360 --> 04:05:17,080 PREVENTED BUT THANK YOU. 5527 04:05:17,080 --> 04:05:21,160 IT SOUNDS LIKE IF IT'S INFECTION 5528 04:05:21,160 --> 04:05:26,400 OR RELATED INFLAMMATION IT CAN'T 5529 04:05:26,400 --> 04:05:27,840 BE A PURSUIT HERE. 5530 04:05:27,840 --> 04:05:28,960 >> YEAH. 5531 04:05:28,960 --> 04:05:34,760 >> OK. 5532 04:05:34,760 --> 04:05:37,840 >> Lynn M. King: ANY OTHER 5533 04:05:37,840 --> 04:05:45,680 COMMENTS? 5534 04:05:45,680 --> 04:05:47,120 DOES ANYONE WANT -- WOULD A 5535 04:05:47,120 --> 04:05:48,520 MEMBER OF COUNCIL LIKE TO MAKE A 5536 04:05:48,520 --> 04:05:49,720 MOTION FOR RECOMMENDATION TO 5537 04:05:49,720 --> 04:05:53,760 APPROVE THIS CONCEPT? 5538 04:05:53,760 --> 04:06:00,000 >> SO MOVED. 5539 04:06:00,000 --> 04:06:00,880 WEN SHI. 5540 04:06:00,880 --> 04:06:03,280 >> SECOND. 5541 04:06:03,280 --> 04:06:04,880 HAL. 5542 04:06:04,880 --> 04:06:05,360 ALL IN FAVOR. 5543 04:06:05,360 --> 04:06:06,320 >> AYE. 5544 04:06:06,320 --> 04:06:11,240 >> ANY OPPOSED? 5545 04:06:11,240 --> 04:06:11,400 OK. 5546 04:06:11,400 --> 04:06:15,480 NOW WE CAN MOVE ON TO Dr. CHAN 5547 04:06:15,480 --> 04:06:25,640 DER'S SECOND CONCEPT. 5548 04:06:25,640 --> 04:06:28,000 THE NEXT TOPIC, GO AHEAD. 5549 04:06:28,000 --> 04:06:29,040 >> THANK YOU. 5550 04:06:29,040 --> 04:06:29,760 THANK YOU. 5551 04:06:29,760 --> 04:06:31,560 SO, IT'S MY PLEASURE HERE TO 5552 04:06:31,560 --> 04:06:32,800 PRESENT THE NEXT CONCEPT AND 5553 04:06:32,800 --> 04:06:43,280 THIS ONE IS TITLED DEVELOPING 5554 04:06:45,000 --> 04:06:47,520 SALIVARY COMPONENTS AS 5555 04:06:47,520 --> 04:06:50,240 THERAPEUTICS OF ORAL HEALTH. 5556 04:06:50,240 --> 04:06:51,680 SALIVA MAINTAIN ORAL HEALTH. 5557 04:06:51,680 --> 04:06:56,240 WHEN IT FLOWS REDUCED, THE OVER 5558 04:06:56,240 --> 04:06:59,800 ALL HEALTH ISSUES LIKE DENTAL 5559 04:06:59,800 --> 04:07:08,040 CARRY, ORAL MY CAN DEVELOP. 5560 04:07:08,040 --> 04:07:10,880 WE ALSO KNOW THAT RADIATION 5561 04:07:10,880 --> 04:07:13,120 INDUCED IN PATIENTS UNDERGOING 5562 04:07:13,120 --> 04:07:14,480 TREATMENT FOR HEAD AND NECK 5563 04:07:14,480 --> 04:07:17,360 CANCER ARE AUTOIMMUNE CONDITION 5564 04:07:17,360 --> 04:07:19,680 ARE OTHER MEDICATIONS AND JUST 5565 04:07:19,680 --> 04:07:21,720 THE GENERAL PROCESS OF AGING, 5566 04:07:21,720 --> 04:07:24,720 ARE KNOWN TO REDUCE AND IMPAIR 5567 04:07:24,720 --> 04:07:26,600 SALIVA PRODUCTION LEADING TO 5568 04:07:26,600 --> 04:07:29,080 VARIOUS HEALTH PROBLEMS IN THE 5569 04:07:29,080 --> 04:07:29,400 MOUTH. 5570 04:07:29,400 --> 04:07:33,000 BUT THERE ARE ALSO EXISTS THE 5571 04:07:33,000 --> 04:07:34,680 CLINICAL ISSUE WHERE THE 5572 04:07:34,680 --> 04:07:36,560 EXISTING SALIVA SUBSTITUTES 5573 04:07:36,560 --> 04:07:37,640 AVAILABLE BEFORE SIGNIFICANTLY 5574 04:07:37,640 --> 04:07:43,160 FROM HUMAN SALIVA AND OUR 5575 04:07:43,160 --> 04:07:44,800 CLINICAL ELECTRICAL CONNECTIVITY 5576 04:07:44,800 --> 04:07:47,680 AND THESE ARE FOR IN ADEQUATE OR 5577 04:07:47,680 --> 04:07:52,800 SHOT DOWN RELIEF IN PATIENTS. 5578 04:07:52,800 --> 04:07:54,440 OVER THE YEARS WE HAVE EX TO 5579 04:07:54,440 --> 04:07:56,080 APPRECIATE THE FACT THAT EACH 5580 04:07:56,080 --> 04:07:57,400 SALIVA COMPONENT PLAYS AN 5581 04:07:57,400 --> 04:07:58,920 ESSENTIAL ROLE IN LOSS OF WHICH 5582 04:07:58,920 --> 04:08:01,400 WILL COMPROMISE HEALTH AND 5583 04:08:01,400 --> 04:08:03,280 REPLENISHING THESE COMPONENTS IS 5584 04:08:03,280 --> 04:08:05,520 ESSENTIAL FOR PROCESSES SOME OF 5585 04:08:05,520 --> 04:08:08,200 WHICH ARE, MANY OF WHICH ARE 5586 04:08:08,200 --> 04:08:10,160 IMPORTANT TO ENHANCING WOUND 5587 04:08:10,160 --> 04:08:11,920 HEALING, AND INCREASING BY OWE 5588 04:08:11,920 --> 04:08:16,440 MATERIALS SURVIVAL, AND 5589 04:08:16,440 --> 04:08:21,080 REPLENISHING (INAUDIBLE). 5590 04:08:21,080 --> 04:08:23,360 THE GOAL OF THIS INITIATIVE IS 5591 04:08:23,360 --> 04:08:25,480 THUS TO ENCOURAGE INTER 5592 04:08:25,480 --> 04:08:28,480 DISCIPLINARY RESEARCH THAT 5593 04:08:28,480 --> 04:08:29,400 HARNESSES THE FUNCTIONAL 5594 04:08:29,400 --> 04:08:31,880 COMPONENTS OF SALIVA TOWARDS 5595 04:08:31,880 --> 04:08:35,760 BIOLOGIC THERAPIES AND THIS WILL 5596 04:08:35,760 --> 04:08:37,320 ENCOURAGE STUDIES FOR THE 5597 04:08:37,320 --> 04:08:38,680 CONSTITUENTS AND IT MOVE THEM 5598 04:08:38,680 --> 04:08:44,800 TOWARDS RECEIPT TWITH A FOCUS OD 5599 04:08:44,800 --> 04:08:46,400 RESILIENCE OF THE ORAL CAVITY SO 5600 04:08:46,400 --> 04:08:48,640 THE OUTCOMES ARE EXPECTED TO 5601 04:08:48,640 --> 04:08:50,800 FACILITATE THE DEVELOPMENT OF 5602 04:08:50,800 --> 04:08:53,440 INDIVIDUALS EFFECTIVE SORROW GOT 5603 04:08:53,440 --> 04:08:56,360 SALIVA FOR CLINICAL APPLICATIONS 5604 04:08:56,360 --> 04:08:59,560 PROMOTE AND RESTORE ORAL HEALTH. 5605 04:08:59,560 --> 04:09:01,200 LIKE THE OTHER ONE, I WOULD LIKE 5606 04:09:01,200 --> 04:09:02,640 TO HIGHLIGHT THAT THIS 5607 04:09:02,640 --> 04:09:04,760 INITIATIVE IS NOT FOCUSED ON 5608 04:09:04,760 --> 04:09:07,320 DEVELOPMENT OF BIOMARKERS OR 5609 04:09:07,320 --> 04:09:09,080 DIAGNOSTIC BUT DEVELOPMENT OF 5610 04:09:09,080 --> 04:09:11,200 BIOLOGIC THERAPIES, NOT THE 5611 04:09:11,200 --> 04:09:15,560 ORGANIC COMPONENTS AND OR EVEN 5612 04:09:15,560 --> 04:09:17,200 PROBIOTICS BUT REALLY THE 5613 04:09:17,200 --> 04:09:18,960 BIOLOGIC COMPONENTS THAT MAKE UP 5614 04:09:18,960 --> 04:09:21,120 SALIVA AND HAVE A FUNCTIONAL 5615 04:09:21,120 --> 04:09:22,400 CONSEQUENCE AND THUS CAN ARE 5616 04:09:22,400 --> 04:09:26,040 RESTORED TO PROMOTE HEALTH OF 5617 04:09:26,040 --> 04:09:27,560 THE MOUTH. 5618 04:09:27,560 --> 04:09:31,040 SO, THE SMALL FRACTION OF 5619 04:09:31,040 --> 04:09:34,360 SALIVA, WHICH IS THE ONE PERSON 5620 04:09:34,360 --> 04:09:41,120 NON COMPONENTS CONTAIN GLYCANS 5621 04:09:41,120 --> 04:09:44,440 THAT ENABLE SALIVA TO PLAY A 5622 04:09:44,440 --> 04:09:46,200 ROLE IN DEFENSE AGAINST 5623 04:09:46,200 --> 04:09:48,320 INFECTIONS AND MAINTENANCE OF 5624 04:09:48,320 --> 04:09:50,560 ORAL MICROBIOME AND WOUND 5625 04:09:50,560 --> 04:09:51,760 HEALING AND MAINTENANCE OF 5626 04:09:51,760 --> 04:09:52,120 HEALTH. 5627 04:09:52,120 --> 04:09:53,480 SO THE EARLY STUDIES THAT WE 5628 04:09:53,480 --> 04:09:57,680 HAVE SEEN SO FAR, HAVE BEEN ABLE 5629 04:09:57,680 --> 04:09:59,360 TO DELINEATE SOME OF THESE 5630 04:09:59,360 --> 04:10:00,640 FUNCTIONS BUT WE'RE AT A POINT 5631 04:10:00,640 --> 04:10:02,400 WHERE WE NEED TO HARNESS THIS 5632 04:10:02,400 --> 04:10:05,080 KNOWLEDGE TO MOVE TO ITS 5633 04:10:05,080 --> 04:10:07,240 THERAPEUTIC DEVELOPMENT OF THESE 5634 04:10:07,240 --> 04:10:09,000 COMPONENTS FOR APPLICATIONS IN 5635 04:10:09,000 --> 04:10:09,840 ORAL HEALTH. 5636 04:10:09,840 --> 04:10:12,680 SOME OF THE DEVELOPMENTS THAT 5637 04:10:12,680 --> 04:10:15,240 COVID AND THE CREATIVITY OF OUR 5638 04:10:15,240 --> 04:10:20,360 INVESTIGATORS HAVE LED TO CAN BE 5639 04:10:20,360 --> 04:10:22,400 SEEN AND THE INTEGRATION OF 5640 04:10:22,400 --> 04:10:24,040 SALIVA AND BLOOD PLASMA 5641 04:10:24,040 --> 04:10:25,960 COMPONENTS AND ENABLE LINKINGS 5642 04:10:25,960 --> 04:10:27,760 SALIVA PROTEINS TO THEIR SOURCE 5643 04:10:27,760 --> 04:10:31,000 AND IDENTIFICATION OF SALIVARY 5644 04:10:31,000 --> 04:10:33,040 GLANDS-SPECIFIC GENES, 5645 04:10:33,040 --> 04:10:33,880 UNCOVERING GENE REPERTOIRE 5646 04:10:33,880 --> 04:10:35,440 LINKING THE EXAMINATION OF THE 5647 04:10:35,440 --> 04:10:38,280 SPECIFIC SALIVARY COMPONENT IN A 5648 04:10:38,280 --> 04:10:46,520 SPECIFIC CONTEXT AND THE HUMAN 5649 04:10:46,520 --> 04:10:47,720 ARE AVAILABLE TO THE COMMUNITY 5650 04:10:47,720 --> 04:10:56,000 AS THE HUMAN SALIVARY PRO TEEOME 5651 04:10:56,000 --> 04:11:00,800 IT INCLUDES SEEKEL CELL 5652 04:11:00,800 --> 04:11:02,680 SEQUENCING OF THE CRANIOFACIAL 5653 04:11:02,680 --> 04:11:03,680 BIOLOGICAL WORK. 5654 04:11:03,680 --> 04:11:04,920 IT'S SPECIFICALLY FOR COVID 5655 04:11:04,920 --> 04:11:09,640 RELATED STUDIES OF THE ORAL 5656 04:11:09,640 --> 04:11:14,680 CAVITY. 5657 04:11:14,680 --> 04:11:18,360 WE CAN SEE THE AREAS OF INTEREST 5658 04:11:18,360 --> 04:11:28,760 THAT THESE DEVELOPMENT. 5659 04:11:49,200 --> 04:11:55,280 WITH THAT EIGHTH I WILL TURN ITE 5660 04:11:55,280 --> 04:11:55,640 REVIEWERS. 5661 04:11:55,640 --> 04:11:57,960 DID SHI WILL GO FIRST. 5662 04:11:57,960 --> 04:12:00,760 >> SO WE'RE SUPER EXCITED ABOUT 5663 04:12:00,760 --> 04:12:03,560 THIS CONCEPT AND THIS IS REALLY 5664 04:12:03,560 --> 04:12:07,200 I THINK IS A QUANTUM LEAP IN 5665 04:12:07,200 --> 04:12:11,080 HIGHLY INNOVATIVE WITH NIDCR 5666 04:12:11,080 --> 04:12:14,600 HAVE INVESTED SO MUCH MONEY ON 5667 04:12:14,600 --> 04:12:20,640 DEVELOPING THE SALIVARY 5668 04:12:20,640 --> 04:12:20,920 PROTEASOME. 5669 04:12:20,920 --> 04:12:21,680 >> Omar: AND THIS IS THE TIME 5670 04:12:21,680 --> 04:12:23,000 AND DISCOVERIES INTO A 5671 04:12:23,000 --> 04:12:35,080 AND WEEXPECT TO HAVE A GREAT OUE 5672 04:12:35,840 --> 04:12:38,240 AND WE'RE EXCITED ABOUT THIS AND 5673 04:12:38,240 --> 04:12:39,320 DURING THE DISCUSSION THE ONLY 5674 04:12:39,320 --> 04:12:43,880 THING WE WANT TO MAKE SURE IS 5675 04:12:43,880 --> 04:12:47,240 LET'S NOT OVERLAP WITH THE 5676 04:12:47,240 --> 04:12:48,440 TRADITIONAL SALIVARY FUNCTION 5677 04:12:48,440 --> 04:12:52,200 WHICH IS A LOOK AT AND IT'S 5678 04:12:52,200 --> 04:12:54,280 INORGANIC COMPONENTS OR THE 5679 04:12:54,280 --> 04:12:55,960 PROBIOTICS AND WE WANT THAT IS 5680 04:12:55,960 --> 04:12:59,760 THE FOCUS ON THE ORGANIC 5681 04:12:59,760 --> 04:13:01,760 COMPONENT OF THOSE SALIVARY 5682 04:13:01,760 --> 04:13:03,760 COMPONENTS THAT WE'VE 5683 04:13:03,760 --> 04:13:04,080 DISCOVERED. 5684 04:13:04,080 --> 04:13:04,600 GREAT CONCEPT. 5685 04:13:04,600 --> 04:13:11,760 VERY EXCITED ABOUT IT. 5686 04:13:11,760 --> 04:13:13,560 >> HE AGREE. 5687 04:13:13,560 --> 04:13:14,720 I'M VERY EXCITE BESIDE THIS 5688 04:13:14,720 --> 04:13:17,200 CONCEPT AND I THINK THAT AGAIN 5689 04:13:17,200 --> 04:13:19,040 Dr. CHANDER DID A WONDERFUL 5690 04:13:19,040 --> 04:13:22,280 JOB PUTTING IT TOGETHER AND VERY 5691 04:13:22,280 --> 04:13:25,040 TIMELY AND I MEAN, WE KNOW FOR A 5692 04:13:25,040 --> 04:13:28,600 VERY LONG TIME THAT SALIVA IS 5693 04:13:28,600 --> 04:13:30,360 VERY IMPORTANT IN MANY 5694 04:13:30,360 --> 04:13:32,080 BIOLOGICAL PROCESSES AND ONE OF 5695 04:13:32,080 --> 04:13:35,920 THEM IS ONE HEALING. 5696 04:13:35,920 --> 04:13:37,080 REALLY UNDERSTANDING WHAT ARE 5697 04:13:37,080 --> 04:13:39,520 THE BIO MOLECULES IN SALIVA THAT 5698 04:13:39,520 --> 04:13:40,760 DO THE JOB? 5699 04:13:40,760 --> 04:13:44,080 IT WILL BE CRITICAL SO IF 5700 04:13:44,080 --> 04:13:45,840 FUNCTION OF STUDIES ARE CRITICAL 5701 04:13:45,840 --> 04:13:51,840 AND THEY MAY LEAD TO NEW 5702 04:13:51,840 --> 04:14:02,240 PRODUCTS AND FROM MID 5703 04:14:06,720 --> 04:14:17,040 INDICATIONS USE AND -- 5704 04:14:25,200 --> 04:14:25,840 >> THANK YOU. 5705 04:14:25,840 --> 04:14:36,080 >> THANK YOU. 5706 04:14:39,840 --> 04:14:41,280 >> YOU CAN THINK BIGGER BECAUSE 5707 04:14:41,280 --> 04:14:42,760 WHEN I SAW THE TITLE AS 5708 04:14:42,760 --> 04:14:44,440 THERAPEUTIC FOR ORAL HEALTH, IT 5709 04:14:44,440 --> 04:14:47,920 OCCURS TO ME AS MANY OF THESE 5710 04:14:47,920 --> 04:14:49,440 DISCOVERIES MAY APPLY TO OTHER 5711 04:14:49,440 --> 04:14:51,000 AREAS OF THE BODY, PARTICULARLY 5712 04:14:51,000 --> 04:14:52,160 WHEN YOU THINK ABOUT WORKING ON 5713 04:14:52,160 --> 04:14:55,280 IT THERE'S A TREMENDOUS NEED FOR 5714 04:14:55,280 --> 04:14:59,200 THERAPEUTICS ALL OVER THE BODY. 5715 04:14:59,200 --> 04:15:01,600 AND IT COULD BE WE KNOW THEY 5716 04:15:01,600 --> 04:15:02,640 FEEL WELL UNDER NORMAL 5717 04:15:02,640 --> 04:15:03,840 CIRCUMSTANCES AND IT COULD BE 5718 04:15:03,840 --> 04:15:05,440 THAT THERE'S SOME VERY IMPORTANT 5719 04:15:05,440 --> 04:15:07,600 DISCOVERY THERE THAT CAN BEING 5720 04:15:07,600 --> 04:15:12,160 TRANSLATED INTO DIABETIC ULCERS 5721 04:15:12,160 --> 04:15:14,640 OR SERIOUS DISEASES SO I GUESS 5722 04:15:14,640 --> 04:15:16,400 WE'RE CONNECTING HEAD BACK TO 5723 04:15:16,400 --> 04:15:18,160 THE BODY AGAIN. 5724 04:15:18,160 --> 04:15:19,920 SO JUST A SUGGESTION. 5725 04:15:19,920 --> 04:15:20,400 THANK YOU. 5726 04:15:20,400 --> 04:15:26,600 >> THANK YOU. 5727 04:15:26,600 --> 04:15:30,520 >> Lynn M. King: ANY OTHER 5728 04:15:30,520 --> 04:15:34,120 COMMENTS? 5729 04:15:34,120 --> 04:15:35,440 WOULD A MEMBER OF COUNCIL LIKE 5730 04:15:35,440 --> 04:15:36,840 TO MAKE A MOTION FOR 5731 04:15:36,840 --> 04:15:39,280 RECOMMENDATIONS TO APPROVE THIS 5732 04:15:39,280 --> 04:15:39,560 CONCEPT? 5733 04:15:39,560 --> 04:15:43,600 >> SO MOVED. 5734 04:15:43,600 --> 04:15:46,200 >> WEN SHI SECOND. 5735 04:15:46,200 --> 04:15:50,080 >> ALL IN FAVOR. 5736 04:15:50,080 --> 04:15:50,240 AYE. 5737 04:15:50,240 --> 04:15:53,360 >> ANY OPPOSED? 5738 04:15:53,360 --> 04:15:53,960 >> Lynn M. King: OK. 5739 04:15:53,960 --> 04:15:55,960 THE FINAL CONCEPT TODAY WILL BE 5740 04:15:55,960 --> 04:15:59,240 PRESENTED BY Dr. LU WANG CHIEF 5741 04:15:59,240 --> 04:16:02,120 OF THE TRANSLATION ALGAE NOMICS 5742 04:16:02,120 --> 04:16:05,160 BRANCH. 5743 04:16:05,160 --> 04:16:15,600 AND SHE WILL PRESENT THIS 5744 04:16:21,120 --> 04:16:21,800 CONCEPT. 5745 04:16:21,800 --> 04:16:23,880 >> THANK YOU, LYNN. 5746 04:16:23,880 --> 04:16:25,680 GOOD AFTERNOON COUNCIL. 5747 04:16:25,680 --> 04:16:28,760 TODAY I SEEK YOUR CONCURRENCE ON 5748 04:16:28,760 --> 04:16:31,560 THE PROGRAM INITIATIVE CONCEPT 5749 04:16:31,560 --> 04:16:35,040 ENTITLED APPLY DATA SIGNS IN 5750 04:16:35,040 --> 04:16:41,000 TRANSLATIONAL DIDN'TAL ORAL AND 5751 04:16:41,000 --> 04:16:42,040 CRANIOFACIAL RESEARCH. 5752 04:16:42,040 --> 04:16:45,280 I WOULD LIKE TO THANKS Dr. 5753 04:16:45,280 --> 04:16:47,400 AXEL VISEL ON THE UPDATE ON THE 5754 04:16:47,400 --> 04:16:49,280 COUNCIL DATA SIGNS STRATEGY 5755 04:16:49,280 --> 04:16:53,040 WORKING GROUP WHICH PROVIDES 5756 04:16:53,040 --> 04:16:55,520 TIMELY, COMPREHENSIVE AND 5757 04:16:55,520 --> 04:16:58,920 EXCITING CONTEXT FOR THIS 5758 04:16:58,920 --> 04:17:00,000 CONCEPT. 5759 04:17:00,000 --> 04:17:03,320 SO, THIS INITIATIVE IS AIMED TO 5760 04:17:03,320 --> 04:17:07,280 PROMOTE EFFORTS AND THE NEXT 5761 04:17:07,280 --> 04:17:08,240 SLIDE, PLEASE. 5762 04:17:08,240 --> 04:17:11,200 THIS INITIATIVE IS AIMED TO 5763 04:17:11,200 --> 04:17:12,800 PROMOTE EFFORTS THAT WILL USE 5764 04:17:12,800 --> 04:17:16,280 AND FACILITATE THE USE OF DATA 5765 04:17:16,280 --> 04:17:19,120 SIZE APPROACHES IN DENTAL, ORAL 5766 04:17:19,120 --> 04:17:24,480 AND CRANIOFACIAL RESEARCH OR DOC 5767 04:17:24,480 --> 04:17:26,360 RESEARCH THAT FANS THE FULL 5768 04:17:26,360 --> 04:17:29,000 SPECTRUM OF BASIC, PRE CLINICAL, 5769 04:17:29,000 --> 04:17:32,240 CLINICAL, CLINICAL 5770 04:17:32,240 --> 04:17:34,160 IMPLEMENTATION AND TOPIC HEATH. 5771 04:17:34,160 --> 04:17:35,680 THE FAR-REACHING APPROACH WILL 5772 04:17:35,680 --> 04:17:38,880 BE TAKEN TO DRAW GRANT 5773 04:17:38,880 --> 04:17:41,680 APPLICATIONS FROM DIVERSE 5774 04:17:41,680 --> 04:17:44,880 TALENTS WHO ARE CURRENTLY ACTIVE 5775 04:17:44,880 --> 04:17:47,120 EITHER IN THE AREA OF DOC OR 5776 04:17:47,120 --> 04:17:50,840 OTHER SITES AND DISEASES OR 5777 04:17:50,840 --> 04:17:53,640 DISEASE AGNOSTIC DATA SIGNS. 5778 04:17:53,640 --> 04:17:55,880 THE BROAD RANGE OF SUPPORTS WILL 5779 04:17:55,880 --> 04:17:59,560 BE PROVIDED INCLUDING FOR 5780 04:17:59,560 --> 04:18:02,400 RESEARCH, RESEARCH AND CAREER 5781 04:18:02,400 --> 04:18:04,320 DEVELOPMENT, PRODUCT 5782 04:18:04,320 --> 04:18:06,920 DEVELOPMENT, AND CONFERENCES. 5783 04:18:06,920 --> 04:18:09,760 OVER ALL, THE INITIATIVE WILL 5784 04:18:09,760 --> 04:18:13,600 PROMOTE THE DEVELOPMENT, 5785 04:18:13,600 --> 04:18:15,520 DISSEMINATION, AND USE OF THE 5786 04:18:15,520 --> 04:18:18,240 STATE OF THE ART DATA SCIENCE 5787 04:18:18,240 --> 04:18:21,760 RESOURCES AND TOOLS IN DOC 5788 04:18:21,760 --> 04:18:23,680 RESEARCH WITH MORE FOCUS ON 5789 04:18:23,680 --> 04:18:25,480 MAXIMIZING DATA REUSE TO DEVELOP 5790 04:18:25,480 --> 04:18:26,920 AND DELIVER EVIDENCE-BASED 5791 04:18:26,920 --> 04:18:37,320 CLINICAL APPLICATIONS. 5792 04:18:38,160 --> 04:18:42,640 THIS INITIATIVE IS INSPIRED BY 5793 04:18:42,640 --> 04:18:46,000 NIDCR'S CURRENT STRATEGIC PLAN 5794 04:18:46,000 --> 04:18:50,080 AND THE DAM ON THE RIGHT IS 5795 04:18:50,080 --> 04:18:54,400 INTENDED TO DEPICT ALL FIVE 5796 04:18:54,400 --> 04:18:59,240 STRATEGIC PRIORITIES AND 5797 04:18:59,240 --> 04:19:02,880 OFFER OPTIMIZED REUSABILITY, 5798 04:19:02,880 --> 04:19:04,520 DATA ANALYTICS, AND STATE OF THE 5799 04:19:04,520 --> 04:19:07,240 ART OF DATA SCIENCE METHODS AND 5800 04:19:07,240 --> 04:19:09,520 RESOURCES AND TO ALLOW 5801 04:19:09,520 --> 04:19:13,560 INVESTIGATORS AND CLINICIANS TO 5802 04:19:13,560 --> 04:19:15,720 CLASSIFY DATA TYPES SO, SORT 5803 04:19:15,720 --> 04:19:18,680 PATTERNS AND UNCOVER LINEAGES 5804 04:19:18,680 --> 04:19:21,680 AND IN SO DOING, ADDRESS 5805 04:19:21,680 --> 04:19:23,760 FOUNDATIONAL TRANSLATIONAL AND 5806 04:19:23,760 --> 04:19:26,240 CLINICAL RESEARCH QUESTIONS. 5807 04:19:26,240 --> 04:19:29,240 AND AS Dr. VISEL PRESENTED, 5808 04:19:29,240 --> 04:19:32,440 FACING THESE CHALLENGES AND 5809 04:19:32,440 --> 04:19:34,560 OPPORTUNITIES, THE COUNCIL DATA 5810 04:19:34,560 --> 04:19:37,360 SCIENCE STRATEGY WORKING GROUP 5811 04:19:37,360 --> 04:19:40,320 HAS BEEN CHARGED TO MAKE 5812 04:19:40,320 --> 04:19:42,720 RECOMMENDATIONS ON DATA SIGNS 5813 04:19:42,720 --> 04:19:43,120 STRATEGIES. 5814 04:19:43,120 --> 04:19:45,840 FOLLOWING THE RECOMMENDATIONS, 5815 04:19:45,840 --> 04:19:48,560 MORE SPECIFICALLY FOCUSED 5816 04:19:48,560 --> 04:19:51,760 FOUNDING AND RESEARCH 5817 04:19:51,760 --> 04:19:53,240 OPPORTUNITIES ARE ANTICIPATED 5818 04:19:53,240 --> 04:19:57,960 WITHIN THE NEXT YEARS DEFINITELY 5819 04:19:57,960 --> 04:20:00,000 IN THE FORESEEABLE YEARS. 5820 04:20:00,000 --> 04:20:02,920 THIS INITIATIVE WILL START NOW 5821 04:20:02,920 --> 04:20:06,640 TO INVESTIGATORS WHO WILL BE 5822 04:20:06,640 --> 04:20:13,640 MORE PRIME TO ACT ON THOSE 5823 04:20:13,640 --> 04:20:23,880 OPPORTUNITIES. 5824 04:20:28,680 --> 04:20:30,280 TO EXPEDITE THE POWER OF DATA 5825 04:20:30,280 --> 04:20:33,000 SCIENCE IN DEVELOPING AND 5826 04:20:33,000 --> 04:20:35,120 DELIVERING HEATH SOLUTIONS. 5827 04:20:35,120 --> 04:20:40,600 NEXT SLIDE, PLEASE. 5828 04:20:40,600 --> 04:20:43,600 SO EXAMPLES OF RESEARCH INTEREST 5829 04:20:43,600 --> 04:20:47,840 UNDER THIS INITIATIVE ARE AS 5830 04:20:47,840 --> 04:20:50,360 FOLLOWS -- MAXIMIZE THE REUSE OF 5831 04:20:50,360 --> 04:20:53,480 RESEARCH AND CLINICAL DATA AND 5832 04:20:53,480 --> 04:20:55,040 ENABLE DATA DRIVEN RESEARCH BY 5833 04:20:55,040 --> 04:20:58,720 MAKING BOTH RETROSPECTIVE AND 5834 04:20:58,720 --> 04:21:00,200 PROSPECTIVE DATA FAIR AND 5835 04:21:00,200 --> 04:21:02,840 MACHINE LEARNING READY. 5836 04:21:02,840 --> 04:21:05,080 AND BY DEVELOPING DATA 5837 04:21:05,080 --> 04:21:07,760 ANALYTICS, COMMON DATA ELEMENTS 5838 04:21:07,760 --> 04:21:10,480 AND SYSTEMS AND AS WELL AS THE 5839 04:21:10,480 --> 04:21:12,640 NATURAL LANGUAGE PROCESSING 5840 04:21:12,640 --> 04:21:19,240 CAPABILITIES THAT ARE APPLICABLE 5841 04:21:19,240 --> 04:21:21,960 SUCH AS ELECTRONIC HEALTH 5842 04:21:21,960 --> 04:21:32,040 RECORDS AND PUBLICATIONS. 5843 04:21:32,040 --> 04:21:34,680 TO IMPROVE DIAGNOSTIC TEST 5844 04:21:34,680 --> 04:21:36,760 EFFICACY AND TREATMENT PLANNING 5845 04:21:36,760 --> 04:21:42,120 AND EXAMPLE MAY BE MERGING RNA 5846 04:21:42,120 --> 04:21:44,640 SEQUENCE BASED DIAGNOSTICS INTO 5847 04:21:44,640 --> 04:21:47,080 DIGITAL PATHOLOGY BASED CLINICAL 5848 04:21:47,080 --> 04:21:49,600 DIAGNOSTICS PIPELINE. 5849 04:21:49,600 --> 04:21:52,920 AND ANOTHER EXAMPLE SPEAKS TO 5850 04:21:52,920 --> 04:21:55,080 THE INTEGRATION OF ELECTRONIC 5851 04:21:55,080 --> 04:21:58,000 DENTAL AND MEDICAL RECORDS TO 5852 04:21:58,000 --> 04:22:01,440 PROMOTE COMPREHENSIVE AND 5853 04:22:01,440 --> 04:22:03,720 DATA-DRIVEN RESEARCH IN ORDER TO 5854 04:22:03,720 --> 04:22:05,600 FACILITATE BETTER INFORMED CARE 5855 04:22:05,600 --> 04:22:10,000 AND TREATMENT PLANNING. 5856 04:22:10,000 --> 04:22:12,800 ALSO, THERE'S OPPORTUNITIES IN 5857 04:22:12,800 --> 04:22:16,360 DEVELOPING DEEP PHENOTYPING DATA 5858 04:22:16,360 --> 04:22:19,080 CURATION AND DATA ANALYSIS WEB 5859 04:22:19,080 --> 04:22:22,960 INTERFACING TO SUPPORT 5860 04:22:22,960 --> 04:22:24,480 DECISION-MAKING FOR INSTANCE, 5861 04:22:24,480 --> 04:22:28,080 INTERFACE MAY HAVE IMAGING AND 5862 04:22:28,080 --> 04:22:29,000 MONDAY AT THE OMICS DATA 5863 04:22:29,000 --> 04:22:30,880 CURATION AND ANALYSIS FUNCTIONS 5864 04:22:30,880 --> 04:22:33,480 FOR CLINICIANS TO USE AND THAT 5865 04:22:33,480 --> 04:22:36,560 IS TO BE INFORMED FOR TREATMENT 5866 04:22:36,560 --> 04:22:37,240 PLANNING. 5867 04:22:37,240 --> 04:22:41,680 LAST BUT NOT LEAST, 5868 04:22:41,680 --> 04:22:44,400 OPPORTUNITIES THERE'S A LOT OF 5869 04:22:44,400 --> 04:22:47,360 OPPORTUNITIES IN BROADLY IN 5870 04:22:47,360 --> 04:22:51,080 RECRUITING DATA AND THEN 5871 04:22:51,080 --> 04:22:53,120 CURATING AND ANALYZING MULTI 5872 04:22:53,120 --> 04:22:55,600 DIMENSIONAL DATA INCLUDING 5873 04:22:55,600 --> 04:22:58,120 BIOLOGICAL, BEHAVIORAL, 5874 04:22:58,120 --> 04:23:00,040 ENVIRONMENTAL, SOCIAL, AND 5875 04:23:00,040 --> 04:23:02,240 HEALTH DATA THAT ARE OBTAINED 5876 04:23:02,240 --> 04:23:06,880 FROM MULTIPLE POPULATIONS AND 5877 04:23:06,880 --> 04:23:08,440 AGE GROUPS AND HEALTH 5878 04:23:08,440 --> 04:23:14,040 DISPARITIES AND PREVENTION AND 5879 04:23:14,040 --> 04:23:16,400 ORAL HEALTH AND CONDITIONS 5880 04:23:16,400 --> 04:23:20,640 INCLUDING CHILDHOOD DENTAL CARE. 5881 04:23:20,640 --> 04:23:23,920 AND SO THAT WAS THE LAST SLIDE. 5882 04:23:23,920 --> 04:23:26,640 WITH THAT, I THANK YOU FOR YOUR 5883 04:23:26,640 --> 04:23:31,280 ATTENTION AND I'M READY TO 5884 04:23:31,280 --> 04:23:41,560 ADDRESS QUESTIONS. 5885 04:23:53,800 --> 04:23:55,680 >> IT WILL COME AS NO SURPRISE 5886 04:23:55,680 --> 04:23:59,600 THAT WE'RE ALL VERY ENTHUSIASTIC 5887 04:23:59,600 --> 04:24:05,080 ABOUT THIS CONCEPT AND IT FITS 5888 04:24:05,080 --> 04:24:07,720 NICELY WITH THE PRESENTATION 5889 04:24:07,720 --> 04:24:10,920 THAT AXEL GAVE ABOUT THE WORKING 5890 04:24:10,920 --> 04:24:11,960 GROUP. 5891 04:24:11,960 --> 04:24:14,880 IT'S OBVIOUS THAT THIS IS SORT 5892 04:24:14,880 --> 04:24:16,880 OF THE NEXT FRONTIER IN SOME 5893 04:24:16,880 --> 04:24:23,840 RESPECT AND IN TERMS OF BEING 5894 04:24:23,840 --> 04:24:28,080 ABLE TO USE THESE MASSIVE DATASO 5895 04:24:28,080 --> 04:24:31,120 THE REAL WORLD AND UNDERSTAND 5896 04:24:31,120 --> 04:24:33,600 MORE ABOUT WHAT IS GOING ON. 5897 04:24:33,600 --> 04:24:38,640 I DID NOT HAVE ANY CONCERNS 5898 04:24:38,640 --> 04:24:44,520 ABOUT ANYTHING IN THE CONCEPT. 5899 04:24:44,520 --> 04:24:45,400 LOU AND I SPOKE A LITTLE BIT 5900 04:24:45,400 --> 04:24:48,400 ABOUT JUST TRYING TO MAKE SURE 5901 04:24:48,400 --> 04:24:50,880 THAT NOT ONLY IS THE MOUTH 5902 04:24:50,880 --> 04:24:53,120 ATTACHED TO THE BODY BUT WE 5903 04:24:53,120 --> 04:24:57,000 THINK ABOUT THE BODY AS BEING 5904 04:24:57,000 --> 04:24:59,600 WHOLE PEOPLE AND SO EMBEDDED IN 5905 04:24:59,600 --> 04:25:00,960 SOCIAL AND CULTURAL CONTEXT 5906 04:25:00,960 --> 04:25:02,120 BECAUSE I THINK THAT'S A PIECE 5907 04:25:02,120 --> 04:25:03,800 OF WHAT WE'RE GOING TO BE ABLE 5908 04:25:03,800 --> 04:25:08,680 TO GET BY MOVING IN THIS DATA 5909 04:25:08,680 --> 04:25:09,480 SCIENCE WAY. 5910 04:25:09,480 --> 04:25:16,840 SO WE WERE SUPER ENTHUSIASTIC 5911 04:25:16,840 --> 04:25:23,640 AND THAT SUMS UP MY THOUGHTS. 5912 04:25:23,640 --> 04:25:27,400 >> THANK YOU, AMY. 5913 04:25:27,400 --> 04:25:30,800 I DON'T HAVE TOO MUCH TO ADD. 5914 04:25:30,800 --> 04:25:33,800 AS PART OF THE WORKING GROUP. 5915 04:25:33,800 --> 04:25:35,440 I'M VERY EXCITED ABOUT THIS 5916 04:25:35,440 --> 04:25:39,640 CONCEPT AND I JUST HAD ANY 5917 04:25:39,640 --> 04:25:40,840 PRESENTATION TODAY HOW DATA 5918 04:25:40,840 --> 04:25:42,880 SCIENCE WILL HAVE MAJOR IMPACTS 5919 04:25:42,880 --> 04:25:44,880 ON ALL AREAS OF NIDCR'S 5920 04:25:44,880 --> 04:25:55,360 ACTIVITIES IN THE FUTURE. 5921 04:26:13,680 --> 04:26:15,120 THAT WE SAW FROM THIS CONCEPT 5922 04:26:15,120 --> 04:26:16,200 DOWN THE ROAD. 5923 04:26:16,200 --> 04:26:18,080 THE OTHER PART THAT I LIKE ABOUT 5924 04:26:18,080 --> 04:26:22,080 THIS CONCEPT IS IT'S VERY BROAD 5925 04:26:22,080 --> 04:26:23,720 AND AS I DESCRIBED DATA SCIENCE 5926 04:26:23,720 --> 04:26:25,400 IS MORE THAN MACHINE LEARNING 5927 04:26:25,400 --> 04:26:27,560 ARTIFICIAL INTELLIGENCE AND THIS 5928 04:26:27,560 --> 04:26:29,040 CONCEPT TAKES A HOLISTIC 5929 04:26:29,040 --> 04:26:30,560 APPROACH AND COVERS ALL OF THESE 5930 04:26:30,560 --> 04:26:32,200 OTHER IMPORTANT COMPLIMENTARY 5931 04:26:32,200 --> 04:26:34,200 AREAS THAT I DESCRIBED AND I 5932 04:26:34,200 --> 04:26:35,000 EXPECTED THEY HAVE TO BE 5933 04:26:35,000 --> 04:26:37,760 PARTICULARLY IMPACTFUL IN 5934 04:26:37,760 --> 04:26:39,400 ADVANCING THE NIDCR MOTION. 5935 04:26:39,400 --> 04:26:42,560 SO, IN SUMMARY, I'M EXCITED AND 5936 04:26:42,560 --> 04:26:43,720 ENTHUSIASTIC AND FULLY 5937 04:26:43,720 --> 04:26:49,600 SUPPORTIVE OF THIS CONCEPT. 5938 04:26:49,600 --> 04:26:50,720 >> Lynn M. King: ANY QUESTIONS 5939 04:26:50,720 --> 04:26:51,160 OR COMMENTS? 5940 04:26:51,160 --> 04:26:52,960 >> IT'S TERRY. 5941 04:26:52,960 --> 04:26:57,520 I'M REALLY EXCITED ABOUT THE 5942 04:26:57,520 --> 04:26:59,880 INTEGRATION OF MEDICAL RECORDS 5943 04:26:59,880 --> 04:27:02,480 AND FROM A CLINICIAN STANDPOINT 5944 04:27:02,480 --> 04:27:06,040 BECAUSE AS IT SAYS, FACILITATE 5945 04:27:06,040 --> 04:27:13,440 AND TREATMENT AND THAT IS SO 5946 04:27:13,440 --> 04:27:23,640 VALUABLE. 5947 04:27:29,920 --> 04:27:38,160 >> ANY OTHER COMMENTS. 5948 04:27:38,160 --> 04:27:39,320 >> ANY OTHER COMMENTS? 5949 04:27:39,320 --> 04:27:40,520 WOULD A MEMBER OF COUNCIL LIKE 5950 04:27:40,520 --> 04:27:42,240 TO MAKE A MOTION FOR 5951 04:27:42,240 --> 04:27:46,120 RECOMMENDATIONS TO APPROVE THIS 5952 04:27:46,120 --> 04:27:46,360 CONCEPT. 5953 04:27:46,360 --> 04:27:48,640 >> I MAKE A RECOMMENDATION. 5954 04:27:48,640 --> 04:27:50,600 >> ANYONE LIKE TO SECOND? 5955 04:27:50,600 --> 04:27:54,400 >> I'LL SECOND IT. 5956 04:27:54,400 --> 04:27:58,480 >> I'LL IN FAVOR? 5957 04:27:58,480 --> 04:28:00,320 >> AYE. 5958 04:28:00,320 --> 04:28:05,520 >> ANYONE OPPOSED? 5959 04:28:05,520 --> 04:28:05,760 OK. 5960 04:28:05,760 --> 04:28:10,040 SO WE REACHED THE END OF THIS 5961 04:28:10,040 --> 04:28:10,360 SESSION. 5962 04:28:10,360 --> 04:28:13,480 AND EYE LIKE TO THANK THE DOCTOR 5963 04:28:13,480 --> 04:28:15,440 FOR PARTICIPATING AND CONTRIBUTE 5964 04:28:15,440 --> 04:28:17,600 TO GO THE DISCUSSIONS. 5965 04:28:17,600 --> 04:28:23,680 AND I WOULD LIKE TO REMIND THE 5966 04:28:23,680 --> 04:28:26,640 LISTENING TO THE AUDIENCE TO YOU 5967 04:28:26,640 --> 04:28:27,880 MAY SUBMIT COMMENTS OR QUESTIONS 5968 04:28:27,880 --> 04:28:30,400 ABOUT THE OPEN SESSION TO THE 5969 04:28:30,400 --> 04:28:31,640 MAILBOX WHICH WE'LL PRESENT AT 5970 04:28:31,640 --> 04:28:34,840 END OF THIS AND I TURNOVER TO 5971 04:28:34,840 --> 04:28:41,440 Dr. RE MARINA VON STAKELBERG Dr. 5972 04:28:41,440 --> 04:28:41,680 D'SOUZA. 5973 04:28:41,680 --> 04:28:42,960 >> THANK YOU, I KNOW HOW HARD 5974 04:28:42,960 --> 04:28:44,400 YOU WORK TO MAKE THESE 5975 04:28:44,400 --> 04:28:45,440 PRESENTATIONS SEAMLESS SO THANK 5976 04:28:45,440 --> 04:28:45,600 YOU. 5977 04:28:45,600 --> 04:28:47,000 YOU ALL DID VERY WELL. 5978 04:28:47,000 --> 04:28:48,600 AND JUST TO LET EVERYONE KNOW 5979 04:28:48,600 --> 04:28:50,440 THAT THAT WHOLE PROCESS OF 5980 04:28:50,440 --> 04:28:53,400 CONCEPT CLEARANCE IS A REALLY 5981 04:28:53,400 --> 04:28:54,840 MULTI-DIRECTIONAL STREAM OF 5982 04:28:54,840 --> 04:28:56,280 INPUT THAT WE SEEK FROM YOU ALL. 5983 04:28:56,280 --> 04:28:58,800 WE PICK UP THE MEETINGS FROM 5984 04:28:58,800 --> 04:29:00,480 PUBLICATIONS AND SO KEEP THAT 5985 04:29:00,480 --> 04:29:04,360 FLOWING BECAUSE THAT'S HOW IDEAS 5986 04:29:04,360 --> 04:29:06,480 GEL AND YOU CAN SEE THERE'S SO 5987 04:29:06,480 --> 04:29:08,160 MUCH TO DO AND SO MUCH WE CAN 5988 04:29:08,160 --> 04:29:09,120 LOOK FORWARD TO. 5989 04:29:09,120 --> 04:29:11,680 SO THANK YOU FOR THAT AFTERNOON. 5990 04:29:11,680 --> 04:29:14,560 I'M LIKELY TO WANT TO CHANGE -- 5991 04:29:14,560 --> 04:29:17,600 I WAS JUST TELLING LYNN YAM THE 5992 04:29:17,600 --> 04:29:19,240 DIRECTORS POWER BECAUSE WE 5993 04:29:19,240 --> 04:29:28,240 BASKETBALBABBLEI. I'M GOING TO H 5994 04:29:28,240 --> 04:29:30,120 THE EXECUTIVE TEAM SO WE MOVE 5995 04:29:30,120 --> 04:29:32,840 THROUGH PRESENTATION AND HAVE A 5996 04:29:32,840 --> 04:29:33,720 LITTLE BIT OF CHANGE AND I'M 5997 04:29:33,720 --> 04:29:37,280 GOING TO TRY A FEW APPROACH 5998 04:29:37,280 --> 04:29:39,080 THAT'S WOULD ALLOW US TO BE 5999 04:29:39,080 --> 04:29:41,000 INTERACTIVE AND ENGAGE 6000 04:29:41,000 --> 04:29:44,120 THROUGHOUT THESE LONG SESSIONS. 6001 04:29:44,120 --> 04:29:46,640 ALWAYS LOOKING FOR SUGGESTIONS 6002 04:29:46,640 --> 04:29:47,120 FROM YOU. 6003 04:29:47,120 --> 04:29:52,040 WAYS TO IMPROVE OUR 6004 04:29:52,040 --> 04:29:55,800 COMMUNICATIONS AND TO TRY TO 6005 04:29:55,800 --> 04:29:58,960 MAKE IT MORE INTERACTIVE IN A 6006 04:29:58,960 --> 04:30:01,120 ZOOM THAT ENGAGES PARTICIPANTS 6007 04:30:01,120 --> 04:30:04,320 NOT IN THIS GROUP OF INTERN ALS. 6008 04:30:04,320 --> 04:30:09,080 WE HOPE TO EXPAND SO WE CAN GET 6009 04:30:09,080 --> 04:30:14,960 CHAT COMMENTS GOING. 6010 04:30:14,960 --> 04:30:16,080 WE'RE GOING TO WORK TOWARDS THAT 6011 04:30:16,080 --> 04:30:17,840 AND OF COURSE THE IN-PERSON 6012 04:30:17,840 --> 04:30:20,200 SESSION THAT HOPEFULLY WE'LL BE 6013 04:30:20,200 --> 04:30:23,680 POSSIBLE FOR MAY HAVE NEXT YEAR. 6014 04:30:23,680 --> 04:30:26,760 THANK YOU VERY MUCH FOR SIGNING 6015 04:30:26,760 --> 04:30:28,800 UP, STICKING WITH IT AND 6016 04:30:28,800 --> 04:30:29,040 ENJOYING. 6017 04:30:29,040 --> 04:30:32,240 I HOPE ENJOYING HEARING ABOUT 6018 04:30:32,240 --> 04:30:33,200 WHERE NIDCR IS MOVING INTO THIS 6019 04:30:33,200 --> 04:30:34,800 NEW ERA OF SUCCESS. 6020 04:30:34,800 --> 04:30:44,960 THANK YOU.