>>WELCOME TO ALL THE VIRTUAL
COUNCIL MEMBERS AND GUESTS TO
THE 231st MEETING OF THE
NATIONAL ADVISORY DENTAL AND
CRANIOFACIAL.
I'M THE DIRECTOR EXECUTIVE
SECRETARY OF THE COUNCIL
MEETING.
I'M GOING TO BEGIN WITH A FEW
INFORMATIONAL AND PROCEDURAL
ITEMS.
TODAY'S PROCEEDINGS ARE BEING
CONDUCTED VIA ZOOM WITH A VIDEO
CAST REVIEWING BY THE PUBLIC.
WE WILL NOT BE TAKING QUESTIONS
OR COMMENTS FROM THE PUBLIC
DURING THE LIVE BROADCAST BUT WE
ENCOURAGE YOU TO SEND QUESTIONS
OR COMMENTS UNTIL
SEPTEMBER 30th, THAT ARE
SUBMITTED TO AN NIDCR E-MAIL
ADDRESS DISPLAYED AT THE END OF
THE SESSION.
WE ASK THAT COUNCIL MEMBERS AND
STAFF PLEASE MAKE SURE THAT YOUR
MICROPHONES ARE SET ON FUTURE
AND WHEN SPEAKING, PLEASE
IDENTIFY YOURSELVES TO ENSURE
THE ACCURACY OF OUR RECORDS.
IF ANYONE PARTICIPATING IN THE
ZOOM VIDEO CONFERENCE NEEDS HELP
WITH TECHNICAL PROBLEMS, TIM,
AND RUSSELL FROM OUR I.T.
SUPPORT TEAM, WILL BE AVAILABLE
TO ASSIST YOU.
AND THEY HAVE PROVIDED THEIR
CONTACT INFORMATION IN THE
CHATBOX.
SO, THE FIRST ORDER OF BUSINESS
WILL BE THE APPROVAL OF THE
MINUTES FROM THE PREVIOUS
COUNCIL MEETING.
THE MINUTES FROM THE MAY 2022
MEETING WERE MADE AVAILABLE TO
COUNCIL MEMBERS FOR THEIR
REVIEW.
ARE THERE ANY COMMENTS OR
CORRECTIONS FROM COUNCIL MEMBERS
FOR THE MAY '22 COUNCIL MEETING
MINUTES?
NO COMMENTS.
WOULD A MEMBER OF COUNCIL LIKE
TO MAKE A MOTION TO APPROVE THE
MINUTES?
>> SO MOVED.
JACK.
>> Lynn M. King: WOULD SOMEONE
LIKE TO SECOND THE MOTION?
>> SECOND, HAL.
>> Lynn M. King: ALL IN FAVOR.
>> AYE.
>> Lynn M. King: AND ANY OPPO
OPPOSED?
NO OPPOSED.
SO AFTER THAT BRIEF
INTRODUCTION, I WILL NOW TURN
THE MEETING OVER TO THE Dr.
D'SOUZA FOR THE DIRECTOR'S
REPORT.
>> THANK YOU, LYNN.
AND I WANT TO SAY REALLY GREET
EVERYONE WARMLY AND MY STAFF AT
NIDCR STAFF WHO HAVE JOINED THIS
SESSION AS WELL AS ALL OUR
STAKEHOLDER GROUPS AND GRANTEES
AND TRAINEES.
IT'S BEEN A VERY INTENSELY
PRODUCTIVE AND REWARDING TIME.
FOR ME, OCTOBER WOULD MARK TWO
YEARS OF BEING HERE AND I MUST
SAY, THE HIGHLIGHT OF MY TERMS
SO FAR HAS BEEN GETTING TO KNOW
OUR COMMUNITY WELL.
THE TRIPS TO SCHOOLS AND TO
ORGANIZATIONS GIVING TALKS HAS
FOR JENNIFER AND ME, BECAUSE SHE
PARTNERS WITH ME IN THIS
JOURNEY, HAS BEEN VERY, VERY
MEANINGFUL AND REWARDING.
WE'VE BEEN GREETED WARMLY AND WE
HAVE A SENSE AND A FINGER ON THE
PULSE AND THE PANDEMIC HAS TAKEN
ITS TOLL.
IT DOESN'T MEAN OUR PROFESSION
AND EDUCATORS AND CLINICIANS ARE
NOT UP TO THE TASK, I THINK IT'S
POINTED OUT SO MANY NEW
DIRECTIONS FOR US AS A COMMUNITY
FOR ORAL HEALTH SCIENTISTS
CLINICIANS.
SO WHAT I WANT TO DO TODAY, IS
TO START OFF WITH THE OVERVIEW
INTRODUCTION OF THANKING
INDIVIDUALS, WELCOMING NEW FOLKS
ON BOARD AND THEN TO MOVE ON TO
GIVING YOU A STATE OF WHERE WE
ARE AS A NATION, WHAT ARE THE
PRIORITIES OF THIS
ADMINISTRATION AND HOW THEY
ACTUALLY INFLUENCE WHAT NIH DOES
AND CERTAINLY NIDCR AS WELL.
I PUT IT IN THE CONTEXT WITH THE
PANDEMIC AND HOW TODAY WE STAND
READY TO REPORT ON SOME OF THE
INVESTMENTS AND NIDCR MADE AND
IT WAS A VERY QUICK PIVOTING,
THE NIMBLENESS, THE CREATIVE TEE
AND INNOVATION SHOULD COME
THROUGH TO YOU ALL.
AND THE KEY MESSAGE IS TO THINK
THAT DESPITE THE TRAGEDY OF THE
PANDEMIC, THAT THE LESSONS IT
HAS TAUGHT US ABOUT HOW WE DO
SCIENCE, HOW DO WE CONVERT WHAT
WE KNOW INTO WHAT WE DO, ARE
REALLY, REALLY IMPORTANT AND
THEY WILL IN FACT GUIDE THE
SHAPING OF OUR FUTURE BEYOND THE
RETURN TO WORKPLACE ISSUES THAT
ARE STILL BEING SORTED OUT AND
WHETHER WE LINGER ON.
LIKE 9/11, WHERE LIFE WILL NEVER
GO BACK WHERE WE CAN WALK
THROUGH AN AIRPORT SECURITY WITH
EVERYTHING ON BOARD, RIGHT.
THAT IS LIKELY NEVER TO CHANGE.
IT COULD BE THAT WE WOULD NEVER
CHANGE AS A SOCIETY, GO BACK TO
PREVIOUS-PANDEMIC TIMES, BUT WE
MAY COME UP WITH THE HAPPY
EQUILIBRIUM WE SEEK.
I WANT TO FOCUS ON NIDCR AND THE
RESEARCH FROM COVID BUT ALSO
BRINGING NEWS TO YOU FROM OUR
INTRAMURAL AND EXTRAMURAL
PROGRAMS.
WE ROTATE OUR SPEAKERS AND I
THOUGHT THIS TIME FOCUSING ON
OUR SUCCESS STORIES AND THEN
WOULD BE A GOOD WAY TO
COMMUNICATE.
BUT EVERYTHING FOR YOU NOW IN
THE CONTEXT OF WHERE THE REPORT
STANDS, WHAT THE DISSEMINATION
HAS BEEN LIKE, WHAT WE HOPE TO
ACHIEVE IN TERMS OF ORAL HEALTH
FOR ALL AND HOW THAT IN FACT IS
CONNECTED TO OUR STRATEGIC PLAN
THAT SERVES AS A ROADMAP FOR ALL
OF US WORKING AT NIDCR AND
BEYOND.
MUCH FOCUS ON DEIA
ACCESSIBILITY, BEING THE TERM
THAT WILL DEFINE THE INCLUSION
AND WELCOMING OF INDIVIDUALS
WITH DISABILITIES AND LGBTQ
COMMUNITY.
NEW INITIATIVES AND PROGRAMS
THAT LINK SO YOU CAN REFER TO
THIS AFTER AS THE POWER POINTS
ARE MADE AVAILABLE TO YOU AND
THEN JUST CASTING A LIGHT ON
WHAT OUR NEXT 25 YEARS WILL
SHAPE UP TO BE.
SO THE WORLD HAS CHANGED AND
I'LL SAY THAT NOW IN NO
UNCERTAIN TERMS AND WE ARE START
OF THAT AND IT TAUGHT US AS CAN
YOU SEE, ABOUT THE IMPORTANCE OF
TEAMWORK, OF INTEGRATION AND
CONNECTING THE DOTS ACROSS THE
BOARD AND THAT IS IN FACT THE
MESSAGE OF TODAY'S REPORT AND
TEAM SCIENCE, TEAMWORK, COMING
TOGETHER WITH THAT SPIRIT THAT
WE CAN DO FARBER WHEN YOU HAVE
COLLECTIVE DIVERSE EXPERTISE AND
IN DETERMINES OF THE NATIONAL
FRONTS IT'S CLEAR THAT NIH IS
MOVING TOWARDS THE AREA OF
TRANSLATION AND I THINK THE
PANDEMIC'S SUCCESS STORIES
AMPLIFY THE IMPORTANCE OF TAKING
RISK AND INVEST NORTH HIGH-RISK
AND HIGH REWARD AND BEING ABLE
TO DO IT MUST FROM THE EVIDENCE
CREATED FROM OUR SCIENTIFIC SIGE
ENDEAVOR AND WE CAN PROVIDE THE
EVIDENCE THAT FORMS THE BASICS
FOR IT.
I'M JUST GUESSING THERE ARE 10
NEW SCHOOLS THAT HAVE OPENED UP
IN THE LAST FEW YEARS AND MORE
TO COME AND CHANGING THE
LANDSCAPE AGAIN OF ACADEMIA AND
PRESSING DEMANDS FOR DIGITAL
TECHNOLOGY BEING SO MUCH AN
INVESTMENT TO DENTAL SCHOOLS
THERE ARE DECLINING LEVELS OF
SUPPORT EVEN AMONGST THE
RESEARCH SCHOOLS AND IF YOU WANT
TO USE THAT TERM, THE SCHOOLS
ARE HEAVILY INVESTED IN IT SO
IT'S IMPORTANT FOR NIDCR TO
MAINTAIN ITS PRESENCE IN THAT
SECTOR AND TO BE ENGAGING OTHER
INSTITUTIONS TO MAKE THIS IN
FACT A COMBINED INITIATIVE, WE
DRAW EVERYONE IN AND EXPAND THE
WORKFORCE TO INCLUDE CLINICIANS,
CLINICAL FACULTY AND OTHERS WHO
IN THE PAST HAVE NOT BEEN THAT
ENGAGE FOR ONE REASON OR THE
OTHER AND WE HAVE VERY STRONG
SUPPORT FOR AND I MUST
ACKNOWLEDGE GRATEFULLY FOR THE
EFFORTS AND ADVOCACY AND REALLY
CREATING THE FORUM WITH GRAINY
AND GRANTEES WHICH ARE GENERAL
SESSIONS AND WE HAVE SEEN AN
INCREASE IN WEBINARS WHERE WE'RE
INVOLVED AND IT'S THE TIME OF
NEW AGE.
MAYBE CONSIDER THOSE FORMS OF
COMMUNICATION AND IN ADDITION TO
OUR TRADITION.
JENNIFER AND I HAVE WORKED HARD
AND WE'LL CONTINUE TO ESTABLISH
STRONG RELATIONSHIPS WITH THE
NATIONAL DENTAL ASSOCIATION,
HISPANIC DENTAL ASSOCIATION AND
THE NATIVE AMERICAN SOCIETY THAT
ARE TOGETHER HAVE FORMED DDS.
THE DIVERSE DENTAL SOCIETY AND
ALONG WITH ADA THAT HAS A NEW
LEADER IN PLACE WE MEET
REGULARLY AND FORGING
COLLABORATIVES AND WE'RE COMING
TOGETHER ACROSS OUR SEEKOSIS
TOMORROW'S BECAUSE OUR CARE AND
OUR MISSION TO PROVIDING QUALITY
AFFORDABLE ORAL HEALTH FOR ALL
IS COMMON TO US AND IT TIES IT
TOGETHER AND OF COURSE THE
SUPPORT OF OUR EDUCATIONAL
LEADERS TO IDEA.
WE ARE ESTABLISHING THROUGH
AADOCR AND OUR DIRECT CONTACT
WITH PATIENT ADD VOW SEE GROUPS
AS THE PORTFOLIO ACTUALLY MOVES
TO A VERY PATIENT-CENTERED FORM.
AND THROUGHOUT NIDCR, THE
EFFORTS OF MATT HOFMANN AND HIS
GROUP OF INTRAMURAL RESEARCHERS
IS COMMENDABLE BECAUSE THERE'S
SO MUCH TRANSLATION OCCURRING
AND IN LABS OF PRIMARILY
COMMITTED TO FOUNDATIONAL
SCIENCE SOMETHING IS TICKING.
AND YOU WILL SEE ME TALK MUCH
MORE ABOUT OUR OFFICE OF THE
CLINICAL DIRECTOR IN A FEW
MINUTES.
VERY WARM WELCOME TO TWO
LONGSTANDING COLLEAGUES, LOUIESA
IS A LEADER IN THE FIELD AT
HIGHER UNIVERSITY LEVELS AND HAS
SERVED ON STUDY SECTIONS,
SOMEONE I KNOW FOR MANY YEARS
AND WILL LEND US A LOT OF WISDOM
IN HER TIME.
ESPECIALLY THRILLED TO HAVE
TERRY DICK INSON.
IT'S IMPORTANT TO BE
REPRESENTATIVE OF THE NEEDS OF
THE COMMUNITY.
YOU'VE BEEN RECOGNIZED BY ADA
FOR DISTINGUISHING SERVICE TO
OUR PROFESSION AND YOU COME IN
AS AN EXPERIENCED CLINICIAN,
LEGISLATE OR HEADING STATE
DENTAL ORGANIZATIONS, ET CETERA.
YOU WERE MY MENTOR IN DENTAL
SCHOOL.
YOU WERE MY PRIVATE SECTOR
MENTOR AND I'LL NEVER FORGET
THAT INFLUENCE YOU HAD ON ME.
I THOUGHT YOUR COMMUNICATION
WITH OUR TEAM IN COUNCIL WOULD
HELP US SHAPE INITIATIVES AND
OPPORTUNITIES SO THAT WE CAN
DRAW IN THAT COMMUNITY AND MAKE
SURE THAT THEY ARE BEING GIVEN
COMPASSIONATE CARE -- SPECIAL
NEEDS.
THRILLED TO HAVE BRINGS
ENTHUSIASM, MATURITY AND WISDOM
TO THIS VERY COMPLEX OFFICE THAT
DEALS WITH COMMUNICATIONS AND
EVER WHICH WAY AND HEALTH
EDUCATION SO WHERE YOU SEE
DEVELOPMENT IS IN THE OUTREACH
ASPECT OF THE OFFICE SO WELCOME
ALICIA AND WE'RE THRILLED TO
HAVE YOU ON BOARD ALONG WITH TWO
IMPORTANT INDIVIDUALS WHO WILL
JOIN THE OFFICE OF SCIENCE,
POLICY AND ANALYSIS.
COMING BACK TO NIDCR, IS GOING
TO HEAD ONE DIVISION AND SHE'S
GOING TO BE CHIEF OF THE SCIENCE
POLICY DIVISION AND MARUSHKA,
ONE OF OUR PAST TRAINEES WHO
COMES FROM GREAT EXPERTISE FROM
NIAID WHERE SHE HEADED OFF
TOBACCO CESSATION PROGRAM SO WE
HAVE TWO VERY OUTSTANDING
INDIVIDUALS WHO WILL HELP SHAPE
OSPA IN THE NEAR FUTURE.
A VERY GRATEFUL TO LESLEY
FREEDON.
MANY HAVE INTERACTED WITH HER,
TRAINING ESPECIALLY HAVE
BENEFITED FROM HER INDIVIDUAL
GUIDANCE AND CARE FOR YOUR
CAREER DEVELOPMENT.
SHE IS MOVING ON TO A VERY
IMPORTANT POSITION AT GEORGE
MAYSON AND HAS DONE ALL THESE
THINGS YOU SEE ON THE RIGHT.
THANK YOU, LESLEY, FOR YOUR
SERVICE WE WISH YOU ALL AND AS I
ALWAYS SAY FOR NIDCR, WE'LL SEE
YOU BACK, HOPEFULLY.
SO WHAT IS NIH STAND TOGETHER?
WE REMAIN A VERY ROBUST
ORGANIZATION WITH BLESSED WITH
SUPPORT FROM CONGRESS AND
FUNDING THAT WAS ABLE TO I THINK
MAKE A HUGE STRIDES DURING COVID
THAT CONTINUES ON PREPARING FOR
THE NEXT PANDEMIC AND HAVING
PLATFORMS OF AVAILABILITY, BOTH
IN THE COMMUNITY AND WITH LABS
AT NIH AND IN ADDITION TO
TRAINING AND COMMUNICATION, WE
ALSO ARE PROUD TO HAVE SEVERAL
NOBLE LAUREATES IN OUR MIDST.
THE SEVEN CENTERS THAT HAVE NO
FUNDING AUTHORITY ACTUALLY ARE
COMING TOGETHER IN A VERY NICE
WAY.
I STRESSED BEFORE, NIDCR AND
NINR THE TWO INSTITUTES THAT ARE
ACTUALLY RESPONSIBLE FOR
SHEPHERDING A PROFESSION OF CANY
ENOUGH ABOUT LARRY TABAK WHO IS
A DDS AS YOU KNOW AND LEADING
NIH TODAY AND WILL CONTINUE TO
DO SO BASED ON HIS COMMUNICATION
AND HE WOULD LIKELY DAY IN THAT
POSITION THROUGH THE END OF THE
YEAR AND THROUGH THE SPRING OF
NEXT YEAR.
LARRY IS DOING AN AMAZING JOB.
HE IS JUST AMAZING.
THE NEXT HIRE IS THE FIRST WOMAN
DIRECTOR OF THE NATIONAL CANCER
INSTITUTE WHO COMES IN FROM
HARVARD MEDICAL, BRIGHAM WOMEN'S
HOSPITAL, SHE'S A CANCER
SURGEON, ONCOLOGIST SURGEON AND
HAS DONE WORK IN THE AREA OF
G.I. ONCOLOGY AND WE'RE HAPPY TO
HAVE MONICA ON BOARD.
PRESIDENT JOE BIDEN HAS CAST OUR
IMPERATIVES FOR US.
HIS PRIORITIES ARE, FUNDING
CONDITIONS THAT ARISE DUE TO SO
MANY VIRUSES AND THREATS THAT IT
IS IMPORTANT FOR US TO CONTINUE
THIS JOURNEY AND SO THERE'S AN
EMPHASIS ACROSS OUR CAMPUS ON
CANCER.
YOU CAN SEE FROM THE PAIN
MANAGEMENT AND SUBSTANCE USE
DISORDER CRISIS THAT WE FACE
THAT THIS HAS TO BE A NATIONAL
PUBLIC-HEALTH ISSUE, A
PUBLIC-HEALTH ISSUE FOR OUR
NATION AND THERE WAS A LOT OF
FOCUS ON COMING UP AT
REPLACEMENTS FOR OPIOIDS,
MINIMIZING THE PRESCRIPTION,
LOOKING AT DIFFERENT WAYS TO
HANDLE CENTRAL VERSUS PERIPHERAL
PAIN MECHANISMS AND THIS IS
CLEARLY APPEARING AS ONE OF THE
SAD ASPECTS OF THE PANDEMIC.
THE RATES OF OPIOID RELATED
SUICIDES, THE RATES OF FENTANYL
CONTAMINATION AND IN DRUGS THAT
ARE USED INCLUDING OPIOIDS IS
JUST SICKENING ALARMING.
WE ARE WORKING WITH NORAH WHO
CAME TO US FROM THE NATIONAL
INSTITUTE OF DENTAL DRUG ABUSE
TO ASK IF WE WOULD COLLABORATE
ON LOOKING AT THE ROLE OF ORAL
HEALTH PROFESSIONALS AND
DETECTING AND REFERRING
TEENAGERS AND YOUNG ADOLESCENTS
THAT ARE SUCK COMING TO THE
STRAIN SO WE CAN COME UP WITH AN
INTERVENTION EFFECTIVE FOR THIS
NATION.
IT'S INTERESTING THAT WE STAND
AS ONE OF THE MOST DEVELOPED
COUNTRIES BUT ALSO HAVE IS THE
WORST STATISTICS WHEN IT COMES
TO LOOKING AT MORBIDITY AND
MORTALITY AND THIS IS SURPRISING
ME WE WOULD RANK UP HIGH THERE.
FOR THAT REASON, THE GOVERNMENT
AS WELL AS NIH HAS PRIORITIZED A
NATIONAL COHORT THAT IS ACTUALLY
GOING TO BE INTERNATIONAL,
LOOKING AT MATERNAL HEALTH
ACTION AND ALL ACROSS HERE, WE
HAVE MANY CONDITIONS WHETHER
IT'S PREGNANCY AND NUTRITION,
FLOOR I HAD, CRANIOFACIAL
ANOMALIES AND NIDCR WILL PLAY A
ROLE IN MATERNAL HEALTH ACTION
AND ALSO PRE-NATAL AND EARLY
PERINATAL HEALTH.
MOST OF YOU HAVE HEARD OF THIS
PROGRAM.
THE FRANCIS COLLINS INITIATED IT
WAS ONE OF HIS FLAGSHIP
INITIATIVES.
DRAWING ABOUT A MILLION PATIENTS
INTO A REPOSITORY INTO A COHORT
CALLED "ALL OF US" AND IT WOULD
INVOLVE FOR THE FIRST TIME
COLLECTING GENOMES AND LOOKING
AT A MULTI-PRONGED APPROACH TO
LOOKING AT WHAT IS HEALTH AND
WHAT IS DISEASE.
VERY POPULATION-SPECIFIC AND
VERY ATTRACTIVE TO US BECAUSE
FOR THE FIRST TIME, WE HAVE A
DIVERSE ARRAY OF DATA TO DRAW
FROM.
NIDCR HAS MANAGED SO THE HELP OF
LILLIAN AND JENNIFER AND I TO
ACTUALLY CREATE A QUESTIONNAIRE
TO INCLUDE QUESTIONS IN THE
HISTORY TAKING THAT WE CAN MINE
FURTHER ON.
THERE ARE PROJECTS THAT ARE
FUNDED THROUGH THE PROGRAM AND
YOU CAN SEE THEM, THEY DEAL WITH
AGE-RELATED OR LIFESPAN RELATED
CONDITIONS, CLEFT PALATE AND
LOOKING AT OUR ELECTRONIC HEALTH
RECORDS AND FROM THE BIG MOUTH
DENTAL DATA REPOSITORY TO
UNDERSTAND HOW ETHNIC
BACKGROUNDS, BEHAVIOR, SOCIAL
ECONOMICS INFLUENCE HEALTH SO
THERE'S A LOT MORE HERE
AVAILABLE TO THE COMMUNITY.
I URGE YOU ALL TO TAKE A LOOK AT
IT.
I BRING THIS UP BECAUSE I THINK
IT SHAPES FOR NIDCR, A VISION
FOR THE FUTURE IN TERMS OF OUR
GLOBAL HEALTH RESEARCH
INITIATIVES.
WE ARE REVITALIZING THE PRESENCE
AND IT'S INTERESTING HOW BILL
AND MELINDA GATES FOUNDATION
INITIATIVE TOOK A HOLISTIC
STANCE ON GLOBAL HEALTH THAN
EVER BEFORE AND SO THEY FOCUS ON
TWO DISEASES THAT ARE PREVALENT
IN AFRICA, HIV AND SICKLE CELL
DISEASE.
YOU CAN SEE FROM THESE OUTLINES
IT'S INVOLVING OMICS IN MANY
WAYS AND IT'S A COMBINATION OF
LOOKING AT THE WHETHER THE
INFRASTRUCTURE IS IN PLACE FOR
SUSTAINABILITY AND ROBUSTNESS OF
HEALTHCARE AND TO BE LOOKING AT
REGIONAL REPOSITORIES ALONG WITH
LOOKING AT GENOTYPE, PHENOTYPE
CORRELATIONS AND THAT TO ME IS
PROBABLY THE FIRST TIME THAT NIH
HAS ENGAGE IN SOMETHING WITH THE
BILL GATES, BECAUSE WE ARE
INVOLVED WITH THAT THAT. IS IN
FACT KEEPING THE PATIENT IN THE
CENTER AND TRANSLATING TO
COMMUNITIES OF RISK AND IN NEED.
WHEN WE THINK WE COULD BE DOING
FOR ORAL HEALTH GLOBALLY AND
THERE ARE A LOT OF NEEDS THERE.
I MENTIONED THE IMPORTANCE OF
HUMAN CONNECTIONS.
IT STRIKES ME NOW IN ADDITION TO
THIS FORUM, WHERE WE CAN ONLY
ACCESS A FEW PEOPLE, BY JUST A
SKIMMING THE SURFACE SO TO
SPEAK.
I URGE ALL COMMUNITIES THAT IN
ADDITION TO THE FORMAL SESSIONS,
WHETHER IT'S LOOKING AT SPECIFIC
MEETINGS THAT YOU HAVE THAT YOU
CAN CONTINUE COMMUNICATION AND
ENCOURAGING IT WITHIN OUR
TRAINEES AS WELL AND THEY CAN
FORM THESE FORM I AM SORRY
THROFORUMS WHERE THERE'SSUCCESSE
BEST PRACTICES.
I THINK THAT LESSON HAS COME
THROUGH CLEARLY TO ME AND ALL OF
THIS PLACE OUT IN THE NEXT FEW
SLIDES AS WE LOOKED AT
PARTNERSHIPS, TEAMWORK,
INNOVATION, THE NEED FOR
BUILDING OF INFRASTRUCTURE WHERE
NEEDED AND SHARK TANK
APPROACHES, HEALTH INEQUITIES,
REMAINING A HUGE CONCERN FOR US
IN ORAL HEALTH.
THE SUCCESS STORIES AND THE USE
OF TELE DENTISTRY IN AREAS LIKE
ROCHESTER AND BLAZING THE TRAIL
THERE, HAS BEEN HUGELY
SUCCESSFUL AND OPEN FOR THE
FURTHER DEVELOPMENT OF THE
FUTURE AS WE USE DATA SCIENCE
AND DEVELOP THE ALGORITHMS BASED
ON ARTIFICIAL INTELLIGENCE AND
MACHINE LEANING TOOLS THAT WE
HAVE GAINED AND SIGNS AND
TECHNOLOGIES AND LEADERSHIP
MATTERS OF COURSE IS OBVIOUS.
SO WHAT CAME OUT OF THIS
BLESSINGS, DESPITE THE SAD
TRAGEDY OF LOSS OF LIVES, WE
HAVE NOW A PROTOCOL IN PLACE
WITH A U.S. PANEL FOR THE FIRST
TIME BUILT TOGETHER SEPARATE
AGENCIES TO THE TABLE TALKING
DIFFERENT LANGUAGES BUT
UNDERSTANDING THE COMMON THEME
TO COME UP WITH WHAT DO WE DO IF
WE HAVE ANOTHER THREATENING
PATHOGEN, WHATEVER IT MIGHT BE.
IT COULD BE BIO TERRORISM OR A
NEW PATHOGEN.
WE HAVE THE PLATFORMS IN PLACE
TO ASSESS THE PATHOGENICITY AND
PLATFORM IN PLACE TO CREATE A
VACCINE, ALL OF THAT NOW IS IN
PLACE AND THAT'S GOOD.
IT ALSO ACCOMPANIES THE WORLD
HEALTH ORGANIZATION REPORT FOR
THE GLOBAL COMMUNITY.
RECOVER IS A IMPORTANT PROGRAM.
PAY ATTENTION BECAUSE IT'S A
REGISTRY OF THOSE WHO SUFFER THE
LONG-TERM EFFECTS OF COVID.
WE HEAR REMARKS AND EXPERIENCES
FROM INDIVIDUALS THAT SUFFER AND
IT'S TELL YOU WILL TERES AND THE
LOSS OF TASTE ASSISTING AND
PROBABLY DUE TO STRESS BUT WE
DON'T HAVE THE DATA IN PLACE SO
IF YOU HAVE PATIENTS THEY CAN
REGISTER AND THEY'RE SYMPTOMS
AND THEY BECOME PART OF THE
STUDY AND THEY HAVE HUBS, THAT'S
THE HUB ACTUALLY THE SPOKES ARE
ALL OVER THE COUNTRY AND IT'S
AVAILABLE ON-LINE.
I'VE THOUGHT OF THIS AS BEING A
WONDERFUL TOOL, REALIZING BY
BOTH FRANCIS COLLINS AND CONNIE
FAUCI THAT WE REALLY DIDN'T HAVE
SCIENCE COMMUNICATION DEVELOP TO
THE EXTENT WE HOPED FOR AND
NIH'S COMMITMENT WAS MADE
EVIDENT BY THIS INITIATIVE WHERE
THE INFRASTRUCTURE IS BEING
BUILT RIGHT NOW FOR THE
ALLIANCES AND READY WHETHER THEY
COME FROM OCCUR OCC -- SHOULD WS
WE CAN INCORPORATORRAL HEALTH
EDUCATION AND LITERACY INTO THIS
WONDERFUL NETWORK THAT I HOPE
WILL SPREAD TO THE REST OF THE
COUNTRY.
SO THAT WOULD BE WHY I THINK
IT'S A BLESSING.
SO WHAT DID WE DO?
WHAT CAME OUT OF OUR DENTAL
PRACTICE-BASED RESEARCH NETWORK?
WE FUNDED THESE STUDIES WITH
GREAT -- IT WAS EFFICIENTLY
CONDUCTED.
THANK YOU TO OUR DIVISION OF
RESEARCH AND WE WERE NOT BIASED
IN OUR APPROACH.
LOOKING AT CLINICAL CONDITIONS,
PATIENTS-CENTERED, WE LOOKED AT
VACCINE ACCEPTABILITY AND
READINESS.
I HAVE A SLIDE ON THAT AND
VARIETY OF VERY CLINICALLY
RELEVANT QUESTIONS THAT OUR
PROFESSION WAS CHALLENGED WITH.
THERE'S A NEW MASS THAT'S
DEVELOPED, IT MAY NOT BE USED
FOR COVID BUT OTHER PATHOGENS
COME OUR WAY AND IT DETECTS
THROUGH PRO TEE ACES IF YOU
ACTUALLY ARE BREATHING THROUGH
YOUR MOUTH AND THESE ENZYMES GET
DEPOSITED AND IT CHANGES THE
COLOR OF AN INDICATER THAT IS
AVAILABLE ON THE MASK SO THAT
AND YOU CAN SEE IT'S BEEN
PUBLISHED AND I WANT TO THANK
THESE INVESTIGATORS COMING UP
WITH THESE STUDIES AND REALLY
DOING THEM IN A VERY STRATEGIC
WAY.
THIS WAS LED BY (INAUDIBLE)
RUTGERS HAS LOOKED AT LONG-TERM
COVID IN CHILDREN AND ASSESS
WHETHER DENTISTS AND WHETHER
THEIR ATTITUDES TESTING AND RISK
MITIGATION AND YOU CAN SEE THAT
EVEN THOUGH DENTISTS WERE LESS
LIKELY TO SELF-TEST, I DON'T
KNOW WHAT THE ROOT CAUSE WOULD
BE BUT WE'RE ADVOCATES AND EVEN
DELIVERED VACCINES SO THIS WAS
AN IMPORTANT STUDY OF AN
OUTCOME.
NOW, IN THIS MAGICAL PERIOD, I
HAVE THIS POSITIVE ATTITUDE
ABOUT WHAT THE PANDEMIC BROUGHT
TO THE CAMPUS CAME THIS
REMARKABLE PROGRAM CALLED RADX
THAT WAS RUN BY THE NIBIB, BRUCE
THORNBERG, THAT LOOKED AT
DIAGNOSTICS THAT WOULD HELP AND
THERE WERE 11 AWARDS MADE
THROUGH THIS PARTICULAR OUTREACH
WHICH WAS TO LOOK FOR BIO
SENSORS FOR SCREENING,
DIAGNOSING AND MONITORING COVID
WITH THE INTENTION THAT THESE
WERE TRANSFERABLE AND
TRANSLATABLE FOR YEARS TO COME.
AND I'M JUST GOING TO GO THROUGH
THESE.
USING TECHNOLOGY IT'S AMAZE WAG
YOU CAN DO.
IT REALLY IS.
IF WE CAN ADAPT TO LOOKING AT
THE STATE OF THE BREATH OR
ANYTHING LIKE THAT THAT WOULD
HELP US PREVENT EARLY AND EARLY
DIAGNOSIS CONDITIONS THAT WE ARE
WRESTLING WITH, THIS WOULD BE
GREAT AND IT'S ALL HOOKED ON TO
SOFTWARE AND YOU CAN ANALYZE
DATA EFFECTIVELY.
WE HAVE AN ANTI BODY AND MULTI
MODEL PLATFORM THAT ACTUALLY
USES ANTIBODIES IN NOW YOU GO
FROM THE MACRO SYSTEM TO A
NANO-CENSUS SYSTEM SO NANO
CENSUS SYSTEMS THAT WOULD ALLOW
US TO POINT OF CARE APPLICATIONS
COME UP WITH SCREENING TOOLS
THAT WOULD BE APPLICABLE FOR THE
FUTURE.
THE ANTIGEN RAPID SLIDER TEST
REALLY BRINGS BACK TO THE
FOREFRONT THE IMPORTANCE OF SAL
A VARY DIAGNOSTICS AND IT
REMAINS THAT PER VEILED THROUGH
THE PANDEMIC OF HIGHLIGHTED THE
ORAL GUT ACCESS AND ITS
IMPORTANT IN TRANSMITTING THE
VIRUS WAS HIGHLIGHTED BY BLACK
WARNER AND HIS TEAM OF
COLLABORATORS AND ADA TO SHOW
THAT IN FACT, THE VIRUS CAN
ATTACH TO SALIVA AND ATTACH TO
TONGUE AND COULD ACCOUNT FOR THE
MANY SYMPTOMS THAT PATIENTS
EXPERIENCE.
SO THIS CREATING THIS HOME CARE
RAPID TEST RELIABLE BASED ON
CHEMISTRY, IS IMPORTANT AND YOU
CAN SEE IT'S A COLOR CHANGE THAT
OCCURS OVER TIME.
NOW, JUST TO GIVE YOU A QUICK,
BRIEF RUN THROUGH WHERE WE ARE
WITH THE REPORT.
I WAS ONBOARDING AS A DIRECTOR
AND FELT THIS WAS THE BEST
PUBLIC SERVICE NIDCR TO CHAMPION
AND DO.
AND WE'RE VERY COMMITTED TO
DISSEMINATING, STRATEGICALLY
AGAIN, BUT WITH THE PURPOSE OF
TRANSFERRING THE OWNERSHIP OF
OUR COMMUNITIES.
ONE OF YOU SHOULD HAVE READ THE
EXECUTIVE SUMMARY, ONLY 25 PAGES
LONG, THE REPORT ITSELF IS 7 # #
0 P790PAGES LONG.
BEN HAD TARGETED FOCUS POINTS
THAT KIND OF CONNECTED THE
THEMES OF REPORT, NOT LIKE IT
WAS PRESENTED BUT IN A UNIQUE
WAY SO THAT EDUCATORS,
CLINICIANS, PUBLIC-HEALTH
DENTIST AND RESEARCHERS WOULD BE
INSPIRED BY WHAT WE NEED FOR THE
FUTURE AND YOU CAN SEE HERE THE
SOCIAL IMMEDIATE WHY HITS ALMOST
10 MILLION AND WE KEEP TRACK OF
THAT VERY RELIABLY.
I THANK THE OFFICE OF
COMMUNICATION FOR DOING THIS FOR
US.
BUT WHAT STRUCK ME WAS THIS
COMMENT THAT WE PUT TOGETHER FOR
THE NEW ENGLAND JUNE ENGLISH JO.
IN OUR COUNTRY TODAY, PEOPLE
EXPERIENCE ORAL HEALTH
DIFFERENTLY.
MANY TIMES NOT BECAUSE OF THEIR
OWN THOUGHTS.
BUT BECAUSE OF AGE, ECONOMIC
STATUS.
WE HAVE TO KEEP IN MIND DESPITE
THE SIGNS AND TECHNOLOGY THAT
WE'RE PROUD OF IN THE LAST 20
YEARS, WE HAVE FOUR OUT OF FIVE
CHILDREN WITH CARE EASE AND
PROBABLY THE MOST COMMON REASON
TO VISIT AN EMERGENCY ROOM BUT
PRESCRIBE DRUGS THAT BECOME
ADDICTIVE TO SO THERE'S A CIRC
OF OF EVENTS, THAT WE NEED TO
ESCAPE WITH SOLUTIONS AND THE
ONLY SOLUTION, AS JENNIFER WILL
ALWAYS TELL ME, WE NEED THE
EVIDENCE AND WE NEED TO
EMPHASIZE PREVENTION SO WE ARE
BALANCING IT BETTER WITH
INTERVENTIONAL-TYPE RESEARCH
STRAT GEESE.
I WAS REALLY ENCOURAGED TO SEE
THIS AND I THANK SANTA FE AND
THE LEADERS IN OUR COMMUNITY FOR
REALLY BEING THAT VOICE FOR US.
THE CURRENT ADMINISTRATION IS
CONSIDER DENTAL COVERAGE.
IT'S A FOOT IN THE DOOR AND I'M
HOPING IT GETS APPROVED AND WE
HAVE ORAL HEALTH AVAILABLE FOR
ALL.
NOW, EVEN THOUGH THE STRATEGIC
PLAN TRULY DEVELOPED
INDEPENDENTLY BECAUSE WE DIDN'T
KNOW WHAT WAS THE DETAILS OF
WHAT WAS IN THE REPORT, WE WERE
DOING IT AT THE SAME TIME, IT'S
AMAZING HOW THEY IN FACT HAVE
PARALLELS AND THE STRATEGIC PLAN
PLACES THE PATIENT IN THE MIDDLE
AND IT EMPHASIZES THAT ALL ARMS
RESEARCHER ARE IMPORTANT AND
THEY ALL FEED INTO UNDERSTANDING
THE HEALTH AND DISEASE, AND THAT
ALL OF THESE CONNECT IN THIS
CONTINUUM WHICH MEANS THAT OUR
STRATEGIES AND FUNDING AND
BRINGING TOGETHER COMMUNITIES
HAS TO BE MORPHED TO MATCH THIS
PLAN.
WORD OF WISDOM, CAME FROM
JENNIFER AND SO WE ARE, WE ARE
ACTUALLY CONNECTING IT'S SUCH
THAT OUR LEADERS AT NIDCR, ARE
BEING EVALUATED IN THEIR
PERFORMANCE EVALUATIONS EVERY
YEAR.
THEIR ANNUAL REPORTS, AS TO WHAT
PROGRESS IS MADE FOR EACH OF OUR
SPECIFIC GOALS THAT ARE OUTLINED
IN THE PLAN, ALL CONNECTED TO
SURGEON GENERAL'S CALL FOR
ACTION AND NOT SURGEON GENERAL
THE ORAL HEALTH IN AMERICA
REPORT CALLS FOR ACTION AND I
THINK THAT WOULD LEAD THEN THAT
CONNECTIVITY WOULD LEAD TO THIS
OUTCOME THAT WE ALL SEEK.
SAYING THIS WITHOUT ANY
HESITATION, WE CAN DO IT ALONE.
JUST NOT THE FEDERAL AGENCY WITH
THE FUNDS TO DISTRIBUTE BUT THE
FEDERAL AGENCIES CHARGE TO MAKE
ORAL HEALTH AVAILABLE FOR ALL
THROUGH SCHOLARSHIP AND
SCIENTIFIC DISCOVERY AND WE HAVE
TO DO IT WITH CLINICAL
CLINICIANS AND EDUCATORS WITH
THE SENSE THAT WE HAVE TO HAVE A
WORKFORCE, A RESEARCH WORKFORCE,
THAT INCLUDES ALL COMMUNITIES IN
THEIR STUDIES AND WHO WILL
PARTICIPATE IN RESEARCH
THEMSELVES AND BECAUSE THAT
WOULD REPRESENT THE DEMOGRAPHICS
OF OUR COUNTRY.
THERE'S ONE THING THAT'S MORE
IMPORTANT TO THE OTHER, THEY
HAVE MUTUALLY REINFORCING AND
THE SYSTEM BENEFITS IF ONE
SUCCEEDS.
SO I LOVE THIS DIAGRAM.
IT CAME FROM THE UNIVERSITY OF
UTAH WHEN I WAS THERE.
THIS IS SO CONSTRUCTIVE FOR ME
TO UNDERSTAND THE DIFFERENCE
BETWEEN EQUALITY AND EQUITY.
EQUALITY PERHAPS IS NOT ENOUGH.
BY GIVING PEOPLE, EVERYONE THE
SAME BENEFITS AND EVERYONE
ACTUALLY HAS A DIFFERENT SET OF
NEEDS.
SO, WHAT WE SEEK IS THAT JUSTICE
WHERE WE HAVE NO BARRIERS AND AS
FEW AS POSSIBLE BECAUSE
PREJUDICE AND BIASES WILL EXIST
IT'S JUST WHAT WE HAVE IN THE
CAPITALISTIC SOCIETY.
WOULD THAT BE WORK FOR THAT
UNIFORM TOGETHERNESS IS
IMPORTANT AND NIDCR IS TAKING
THAT VERY SERIOUSLY AND IT'S
PART OF AN CAMPUS WIDE PLAN
CALLED UNITE AND MANY OF OUR
NISH IT WAS COMING THROUGH NIH
THAT WE LEARNED FROM ALL THE
TIME.
WE GET TRAINED AND WE UNDERSTAND
DIFFERENCES AND MUCH BETTER THAN
WE DID BEFORE AND THIS REALLY
RELATES TO OUR FUNDING
STATISTICS THAT IS IMPROVING
STEADILY, MORE EARLY STAGE
INVESTIGATORS GETTING FUNDED AND
FAR MORE UNDER REPRESENTED
INDIVIDUALS BEING SUPPORTED IN
DIFFERENT WAYS AND GRASS ROOTS
MOVEMENTS WHO TRAIN INDIVIDUALS
TO WRITE GRANTS AND HAVE THE
MENTORING THAT THEY NEED IN AN
INSTITUTION WHOSE CULTURE IS
ACTUALLY CREATING THE BETTER
SENSE OF BELONGING BECAUSE IF WE
HAVE BELONGING, IT SEEMS LIKE
THE OTHER PIECES WOULD NATURALLY
FALL IN PLACE, AND THESE TWO ARE
REALLY NIDCR'S PRIMARY MISSIONS
AND THEY'VE BEEN LED BY JENNIFER
AND HER TEAM, KELLY FROM
DIVISION OF TR INTRAMURAL RESEAS
WELL.
THE TRANS NIH PROGRAMS AND WE
ARE LEVERAGING FROM AND BECAUSE
AS YOU KNOW OUR BUDGET DOESN'T
MATCH THAT OF THE BIGGINS TO USE
THE AND THE MULTI BILLION DOLLAR
FUNDING MECHANISMS.
SO WE HAVE TO TAKE ADVANTAGE
RELATE TODAY PAIN AND AND WE
HAVE RIGHT NOW A FUNDING
OPPORTUNITY THAT IS LOOKING WE
HAVE A STRIKING VIEW AND THEY
ARE REMARKABLE AND CHARGING IN
EVERY RESPECT.
THERE'S NOTHING LIKE DENTAL PAIN
WHERE YOU HAVE NO ROOM TO
ACTUALLY SPAN AND YOU HAVE HARD
TISSUE AND CASING.
YOU HAVE THE PAIN OF CANCERS AND
YOU HAVE -- I CAN GO ON AND ON.
WE HAVE VERY CHALLENGING
SITUATIONS THAT NEED TO BE
LOOKED AT.
LOOKING AT ALL COMPLICATIONS
IT'S OPEN NOW TO LOOKING AT THE
DRY MOUTH THAT IS -- OR THE LACK
OF SALIVA THAT IS SITUATIONS
THAT ARE NORMALLY ACCOMPANY
LONG-TERM DRUG USE AND FINDING
WAYS IN WHICH WE CAN CIRCUMVENT
AND MITIGATE SIDE EFFECTS FROM
NEW THERAPIES THAT HAVE COME UP.
THIS IS A FASCINATING INITIATIVE
THAT WAS A PARTING GIFT TO FROM
FRANCIS.
FOR GENE THERAPY IS THAT USES
ADD NOR VIRAL VECTORS REAPPROVED
SO THE PLATFORM THAT GOES
THROUGH FDA APPROVAL FOR SAFETY
AND EFFICACY BY ITSELF AND MADE
AVAILABLE AS THE PLATFORM IN
WHICH INDIVIDUALS CAN PUT THE
GENE OF INTEREST OR THE CDNA
INTEREST TARGETING THE TISSUE
INTEREST SO YOU FAST TRACK A
THERAPY THROUGH FDA WITHOUT
HAVING TO GO THROUGH THE INITIAL
APPROVAL AND THERE WAS A RFA
RELEASED AND THERE WERE 14
CANDIDATE GENES THAT MADE THE
CUT WHICH THREE RELATE TO WHAT
WE DO IN ORAL HEALTH, FOP
PARTICULARLY AND ANOTHER TWO
SYNDROMES.
I WAS HOPING I COULD HAD A GROUP
OF THE REAL EXPERTISE LIES
OUTSIDE THE U.S. SO THEY WEREN'T
QUITE ELIGIBLE TO COMPETE.
I WANT TO LET EVERYONE KNOW THE
LOAN REPAYMENT PROGRAM IS
BROADENING THE SCOPE OF
INFLUENCE HERE.
IT USED TO BE ONLY FOCUSED ON
THOSE WHO WERE FACULTY,
DEPARTMENTISTS, SCIENTISTS AND
PEDIATRIC RESEARCH AND IT'S
EXTENDED TO CLINICAL HEALTH
DISPARITIES RESEARCH AND OF
COURSE, AREAS THAT ARE POLITICAL
TO HUMAN HEALTH.
SO WE SUPPORT THAT AND IT'S
CALLED REACH AND WE ARE HOPING
FROM FAR MORE INTEREST AND
INVOLVEMENT FROM OUR COMMUNITY
BECAUSE AS YOU KNOW, DENTAL
SCHOOL TUITION AND LOANS ARE
REALLY ON THE RISE AND I DON'T
SEE THAT IS GOING TO REVERSE IN
THE NEAR FUTURE BECAUSE OF THE
PANDEMIC TOLL ON CLINICAL
REVENUES.
SO WHEN I WAS HERE THE LAST
COUNCIL WHEN LARRY TABAK SPOKE
AND I PROCEEDED HIM, HE REALLY
BROUGHT TO LIFE THE SUCCESSES
FROM THE DIVISION OF INTRAMURAL
RESEARCH AND I'D LIKE FOR
COUNCIL FOR ME TO KIND OF SHARE
THE VIEW THE PROGRESS AND THE
THINKING AND THE SIGNIFICANT
ADVANCE FROM OTHER GROUPS AS
WELL.
TODAY WE'LL FOCUS ON JANICE
LEE'S LEADERSHIP AND HER SUCCESS
WITH THE OFFICE OF CLINICAL
DIRECTOR WHICH IS PART OF THE
DIVISION OF INTRAMURAL RESEARCH
BUT STANDS AS AN INDEPENDENT
ENTITY.
VERY COLLABORATIVE WITH THE
OTHER ONE AND LILLIAN'S WORK IN
STRAT MURAL I SCRATCH MY HEAD TO
THINK OF WHAT A REMARKABLE SET
OF ACHIEVEMENTS THESE GROUPS
HAVE MADE.
SO, FOR EVERYONE THAT HASN'T
BEEN TO NIH, OUR PRESENCE IS
FELT IN BUILDING 10 WHERE WE SEE
PATIENTS WITH RARE AND
UNDIAGNOSED CONDITIONS ACROSS
THIS AMAZING COMPLEX OF BUILDING
WHERE THE LATEST CLINICAL TRIALS
IS ON GOING AND THREATENING
DISEASES ARE BEING COMBATED SO
THERE WAS A TEAM OF DENTIST
STAFF, DENTIST HOSPITAL AND
NURSES THAT WORK TOGETHER FOR
THE BENEFIT OF THIS PATIENTS.
THE INVESTIGATORS, THE SEVEN OF
THEM, ALSO ARE PART OF THE
DIVISION OF INTRAMURAL RESEARCH
ARE ENGAGE IN VERY IMPORTANT
AREAS OF RESEARCH.
THEY'RE NOT AS REPRESENTED AS
WELL IN STRAT MURAL AND FOR THAT
ALONE, THIS UNIT PLAYS A VERY
IMPORTANT ROLE AND I LIS LISTEM
HERE EACH ONE OF THEM THRIVING
IN THEIR OWN RIGHT AND THE
PATIENT IS AT AT THERE SO THEY
SEE PATIENTS WITH THESE
CONDITIONS AND TREATING THEM
WITH THERAPY UNDER APPROVAL NOW
OR IN TESTING AND MAKING A
DIFFERENCE TO THESE PATIENT HE'S
LIVES ONE EXAMPLE OF THE SUCCESS
STORY HAS GROWN OVER THE YEARS
FROM THE HARD-WORKING GROUP OF
THE BIOLOGY BRANCH OF DIR, LED
BY MIKE COLLINS AND Dr.
COLLINS AND THEY LITERALLY GO
FROM TRANSLATIONAL TO BENCH TO
BEDSIDE WITH AMAZING PROGRESS
MADE IN THESE PRE PRINCIPLE
AREAS AND WE WOULD BE DEDICATING
ONE OF THOSE IN A SYMPOSIUM NEXT
YEAR SO THAT WE BRING FOCUS AND
BRING THIS TO THE COMMUNITY.
YOU CAN SEE IN ALL OF THESE
CONDITIONS THAT THERE'S THAT
NATURAL TRANSITION FROM
UNDERSTANDING HISTORY TO DOING
ROBUST GENETICS UNDERSTANDING
THE MOLECULAR MECHANISM WITH THE
GOAL OF COMING UP WITH A
THERAPY.
HERE IS AN EXAMPLE OF WHAT IS
HAPPENED IN EACH OF THESE AREAS
AND IT'S A FGF BIOLOGY AND
SIGNALING FASCINATING AND NOW
WHAT IS REMARKABLE IS THAT IN
THE SHORT PERIOD OF TIME, THE
INFRASTRUCTURE FOR CREATING THAT
PLATFORMS WHERE THEY TAKE AN
IDEOLOGY ON IDEATION INTO AN
ACTUAL THERAPY HAS BEEN TESTED
IN UNION ET WHERE WE HAVE
SEVERAL COMPANIES, ABOUT 15 THAT
ARE UNDERWAY RIGHT NOW AND THAT
ARE TESTING NEW THERAPIES FOR
THESE INDIVIDUALS AND ALONG WITH
THE FACT THAT FOR THE FIRST TIME
WE HAVE FORMALIZED
COLLABORATIONS WITH UNIVERSITIES
AND INVESTIGATORS OUTSIDE NIH
THAT WORK, WHOSE EXPERTISE IS
CRITICAL FOR THE SUCCESS OF
THESE STUDIES.
YOU CAN SEE THE CONNECTIONS OF
THESE INVESTIGATORS, JACKIE AND
ALISON BOYS, MIKE COLLINS, HERE
IS JANICE AND THE GROUP OF OR AN
SURGEONS THAT COME DURING THIS
SUMMER PERIOD FROM HARVARD
UNIVERSITY TO EXPERIENCE THIS
SIDE OF THEIR TRAINING THEY
DON'T GET IN THEIR INSTITUTIONS.
I WOULDN'T BE GREAT OF YOU FOR
DOING THIS AND PATTING OURSELVES
ON THE BACK, IT WOULD BE
CREATING THE MODEL FOR THE REST
OF THE COUNTRY AND SHOULD OTHER
SCHOOLS TAKE THIS ON?
AND CREATE A CLINICAL RESEARCH
FELLOWSHIP PROGRAM THAT IS
IMMERSES INDIVIDUALS IN CLINICAL
RESEARCH METH OLD GEE THAT HAS
THE PATIENT IN THE CENTER.
THIS PROGRAM HAS NOW COMPLETED
ALMOST SEVEN YEARS I BELIEVE AND
SETTING THE STAGE IS NATIONALLY
VISIBLE AND IT IS AVAILABLE FOR
ALL WHO HAVE DDSs AND DDBHDs
AND CAN YOU SEE THAT INDIVIDUALS
DO GET PLACED WHERE THEY SHOULD
BE AND SO THERE'S A PLACE FOR
THEM AND IT'S NOT ALWAYS IN
DENTAL SCHOOLS BUT THEY'RE
LEADERS IN OUR COMMUNITY.
VERY HAPPY THAT NATALIA CHALMERS
IS THE FIRST CHIEF DENTAL
OFFICER FOR CMS IS IN PLACE NOW
AND SHE WAS A GRADUATE OF THIS
PROGRAM.
HAPPY TO HAVE SHAWN AND HIS
BEAUTIFUL SMILE TO HAVE HIM ON
BOARD AND JACKIE HELPS AND RUNS
THE PROGRAM WITH JANICE'S
GUIDANCE.
AND SO AGAIN, THANK YOU, MATT,
FOR KEEPING THE INTRAMURAL
PROGRAM STRONG AND ROBUST.
YOU'VE DONE WELL IN DIVERSIFYING
OUR POOL OF INVESTIGATORS,
TRAINEES AND THE RESEARCH THAT
IS MOVING CLEARLY IN TRANSLATION
AREAS.
VERY THANKFUL FOR THIS.
NOW, WE HAVE THE AMAZING PROGRAM
FOR WHICH $350 MILLION OF OUR
TOTAL BUDGET GOES TO, WHICH JUST
TO FUND YOU IN THE EXTRAMURAL
WORLD AND YOU CAN JUST RUN
THROUGH THIS LIST AND YOU SEE WE
COVER SO MUCH.
THESE ARE INDIVIDUALS, WE FUND
OUR PRINCE PLEA OURS AND
DIFFERENT KINDS OF TRAINING
GRANTS AND CO-OPERATIVE
AGREEMENTS AND AS THE AGE
DICTATED, WE FUNDED INDIVIDUALS
OR INDIVIDUAL PROJECTS AND NOW
THEY'RE GOING TO SEE A TREND TO
DECKING THE DOTS.
THEY CAN BE ENGAGE COMMUNITIES
WORKING AT DIFFERENT ASPECTS OF
THE PREVENTION AND WE COULD
BRING ALL CANCER TO THE FLOOR
USING THESE CROSS-CUTTING
THEMES.
NOW, IT DOESN'T ALWAYS HAVE TO
TAKE MONEY, SOMETIMES IT JUST
TAKES A COMMITMENT FROM THE
OUTSIDE WORLD TO CREATE THESE
FORMS OF COMMUNICATION SO THIS
IS A SHARING OF CURRENT
KNOWLEDGE AND BEST PRACTICES AND
SO HERE ARE EXAMPLES OF THE SIX
NOTICES OF SPECIAL INTEREST SO
YOU CAN SEE WHEN YOU GO THROUGH
THEM THAT THEY ARE DIVERSE AND
THEY COVER DIFFERENT ASPECTS OF
OUR PORTFOLIO.
HEALTH DISPARITIES AND DIVERSITY
HELP DISPARITY RESEARCH BEING
THE CENTER.
I MENTIONED THIS BEFORE, DRAWING
FROM THE SUCCESSES THAT OUR
DISTINGUISHED SPEAKER WILL
AMPLIFY AND CAME, THE IDEA THAT
IF YOU INCORPORATE IN THE
SYSTEMS APPROACH RESEARCH THAT
WOULD DRAW AGAIN IN A CONNECTED
WAY COMMUNITIES ACROSS OUR
SOCIAL AND SALIVARY COMMUNITIES
TO REALLY COME UP WITH
THERAPIES, WITH EARLY
INTERVENTIONS AND DIAGNOSIS TO
THIS COMPLEX DISEASE THAT
EFFECTS SO MANY AND MORE WOMEN
THAN MEN AND THIS WAS AWARDED TO
THE UNIVERSITY OF CALIFORNIA AT
SAN FRANCISCO LED BY CAROLINE
SHABOSKI WITH GREAT PARTNERSHIPS
WITH JOHN HOPKINS, OKLAHOMA,
NIDCR AND NIAMS SO WE'RE ALL ON
IT TOGETHER.
AND NED SHARP LESS, BEFORE HE
RETIRED, CAME ON BOARD WITH ME
TO KICKOFF A THINK-TANK DRAWING
ALL CANCER RESEARCHERS TO THE
FIELD AND RECOGNIZING THAT HPV
POSITIVE EXCEED CERVICAL CANCERS
IN TERMS OF HPB AND THEY'RE
THREATENING.
WE DETECT THEM TOO LATE, WE
DON'T HAVE RELIABLE BIOMARKERS
AND THE TREATMENT STRATEGIES ARE
SOMETIMES VERY HARSH WHERE YOU
TAKE OUT ALONG WITH THE TONGUE
BUT HUGE ISSUES FOR PATIENTS AND
THE PREVENTION ASPECTS STILL
NEEDING TO BE REINFORCED SO WITH
NCI WE HAVE AN INITIATIVE CALLED
AHEAD AND THAT I HOPE WILL DRAW
INDIVIDUALS FROM OUTSIDE ORAL
HEALTH SCIENCES TO COME TO THE
TABLE TO HELP US WITH IMAGING,
EARLY DIAGNOSIS, ET CETERA.
THE SAME ATTITUDE OR PHILOSOPHY
WAS APPLIED TO TMD AS YOU KNOW,
IT'S EXISTED, WE FUNDED QUITE A
BIT.
WE HAD 48 INDIVIDUAL AWARDS
RIGHT NOW.
HAVE WE REALLY COME UP WITH A
PATIENT-CENTERED APPROACH WAS
THE QUESTION WE ASKED OURSELVES.
WE LEARNED FROM THE ACADEMY'S
REPORT.
WE HAD THE DEDICATION OF A
PATIENT ADVOCACY GROUP LED BY
JUST INDIVIDUALS WHO CARE SO
DEEPLY.
TERRY COLLIE THANK YOU FOR THAT
COMMITMENT AND BROUGHT TO PLAY
INDIVIDUALS WHO DIFFERENT
INSTITUTES AND CENTERS SO IT WAS
A MULTI-COUNCIL WHO
REPRESENTATIVES THAT MADE
RECOMMENDATIONS WITH THE
WELCOMENESS AGAIN AND LILLIAN
THAT IT WAS THOUGHT THE BEST
NATIONAL COLLABORATIVE AND CAN
YOU SEE THAT THIS IS JUST NOT
INVOLVING THE JOINT ITSELF BUT
PERRY ARCTIC YOU LAR CONDITIONS,
TISSUE, AND WITH THE PATIENT AT
THE CENTER.
THANK YOU FOR THOSE WHO ACTUALLY
DID RESPOND TO SOUR CALLS.
WHAT IS THIS DOING TO YOUR
LIVES?
I WILL SAY, THAT INDIVIDUALS ARE
DRIVEN TO SUICIDES AND WE GET
THOSE NOTICES AS WELL.
BECAUSE OF JUST EXTREME PAIN AND
DISCOMFORT, NOT BEING ABLE TO
OPEN YOUR MOUTH, FAILED
SURGERIES, ET CETERA.
WE HAVE TO DO THIS IN A MATTER
THAT WOULD CREATE A WAVE OF
CHANGE FOR THE FUTURE.
AND IT INCLUDES INVOLVING MULTI
STAKEHOLDERS, AND WE'VE GOT TO
REALLY BRILLIANT GROUP OF
PARTNERS FROM NIH AND EDUCATING
AND TRAINING THE NEXT GENERATION
TO GET INVOLVED IN THIS
RESEARCH.
AND TO KEEP THAT ENTHUSIASM UP.
SO THIS IS CALLED IMPACT SO THE
FIRST ONE IS AHEAD AND IMPACT
AND THEN WE HAVE ONE MORE
COMING.
SO THIS IS THE TIMELINE IN PLACE
FOR THE RELEASE OF THE
ANNOUNCEMENT AND WE ARE
OBVIOUSLY WANTING TO SUPPORT A
PLANNING PHASE INITIALLY.
HOPING THAT TEAMS WILL COALESCE
TOGETHER IN A VERY THOUGHTFUL
WAY TO ADDRESS NOT ALL OF THE
GOALS BUT AT LEAST MANY IN A
VERY MULTI-DISCIPLINARY WAY.
WE ENCOURAGE OUTSIDE
PARTICIPATION FROM EXPERTS IN
PAIN AND NEUROSCIENCES AND
BIOLOGY AND IN CARTILAGE
REGENERATION, AND THE WHOLE
SPECTRUM.
AND AFTER THE PLANNING PHASE, WE
WILL VISIT THE CONCEPT OF
IMPLEMENTATION AND THE EXECUTION
OF THE RESEARCH.
SO THAT'S THE WAY IT'S GOING TO
UNFOLD.
THIS ONE WILL EXCITE ALL OF YOU
IF IT HASN'T ALREADY.
IT'S CALLED PRIME.
NOTE WE ARE PRIMED TO MOVE AHEAD
WITH IMPACT.
SO SOMEHOW THOSE THREE ACRONYMS
SEEM TO FIT INTO A SENTENCE THAT
IS MEANINGFUL FOR US AND THIS IS
A CULTURE-CHANGING
TRANSFORMATIVE PROGRAM AND COMES
WITH IT RISKS, I DO SOMETIMES
WAKE UP AT NIGHT THINKING ABOUT
THEM AND WORRY ABOUT IT.
IT'S TO CREATE DENTAL SCHOOLS
THE ACCEPTS OF EXCITEMENT OF
CURIOSITY, OF ENGAGEMENT, OF
BELONGING TO RESEARCH BY USING
THE PATIENT AT THE EXPERIMENT AS
WE'RE DOING ALL OUR PROCEDURES
IN A SAFETY NET UNIT,
UNPARALLELED IN OUR SOCIETY.
DENTAL SCHOOLS TREAT PATIENTS
FROM SIMPLE TO COMPLEX TO VERY
SPECIAL NEEDS, MEDICALLY
COMPROMISED, RIGHT.
AND WE HAVE DIGITAL TOOLS TO
ASSIST US IN KEEPING THOSE
RECORDS HOLISTIC AND ACTIVE AND
TO ENGAGE OUR STUDENTS AND OUR
FACULTY WITH SOME TRAINING, OF
COURSE, TO ENGAGE THEM WITH
CTSAs ACROSS CAMPUS SO THAT
SMALL SCHOOLS ARE THOUGHT THEY
DON'T BUILDING BECAUSE THEY
DON'T HAVE THE RESOURCES OR
INFRASTRUCTURE TO FEEL THEY CAN
ACTUALLY PARTNER WITH A SCHOOL
THAT CAN E -- IF YOU HAVE A LARE
MEDICAL SCHOOL ON SITE THAT
WOULD BE ANOTHER PARTNERSHIP
THAT COULD WORK VERY WELL.
WE ARE CONDUCTING A WEBINAR CAN
YOU SEE THE APPLICATION WILL
ENCOURAGE THESE FOUR, THEY'RE
MUST SO THEY HAVE TO HAVE THESE
FOUR COMPONENTS AND FROM THERE
WILL BE CLINICAL SCHOOL ARREST
FOR THE PRIVATE SECTOR WHO WOULD
ENGAGE IN THE NATIONAL PRACTICE
BASED RESEARCH NETWORK WHO COULD
COME TO TERRY DICK INSON'S CALL
FOR ACTION IN VIRGINIA GET
INVOLVED IN COMMUNITY RESEARCH
AND PROVIDING THE EVIDENCE WE
NEED FOR POLICY REFORM AND THERE
ARE SO MANY OTHER MAGICAL FALL
OUTS.
DO THEIR MASTERS AND
WELL-INFORMED THIS IS MEANINGFUL
SCIENCE AND MAKE A DIFFERENCE TO
SPECIALTIES AS WELL.
HERE ARE THE NEW OPPORTUNITIES
THAT WE HAVE AVAILABLE AND ONE
TO DEVELOP A NEW SET OF
MATERIALS.
ORLANDO AND JAYS AN JUST RAN A
BRILLIANT THINK-TANK.
WE HAD PEOPLE WHO STANFORD AND
OTHER TO IN M AND LOOK WHAT
WE'RE DOING IN THE AREAS OF
DENTAL MATERIAL SCIENCE AND NOT
ONLY WITH THE FOCUS OF COMING UP
WITH THE REPLACEMENT ABOUT THE
USEFULNESS AS A RESTORATION THAT
LASTS LONG IS LOW COST IS
IMPORTANT AND WE HAVE MATERIAL
THAT TAKES ADVANTAGE OF HOST
RESPONSES AND CAN PREVENT THE
CURRENT DECAY, ET CETERA.
HERE IS ANOTHER ONE THAT IS
LOOKING AT DATA-DRIVEN TOO SO WE
CAN ACTUALLY MOVE BIO MATERIALS
DOWN FASTER AND THAT'S SUCH AN
EXCITING AREA, THIS WAS ACTUALLY
GOING TO BE THE TECHNICAL
WEBINAR THAT WOULD PROVIDE THE
ADDITIONAL INFORMATION THROUGH
Q&As SO THAT ANYONE INTERESTED
IN THIS AREA COULD BE WELL
POSITIONED TO SUCCEED.
I MENTIONED THIS BEFORE AS BEING
A HEALTH EQUITY PROGRAM DRIVEN
TOWARDS DIVERSE TRAININGS AND WE
WANT TO LOOK TO AN R25 AND IN
LOOKING AT SEX AS A BIOLOGICAL
VARIANT AND COMING UP AS
COMPETENCY AND CULTURAL
SENSITIVITY AND TREAT STRATEGIES
BASED ON THE BIOLOGY AND HOW
BEST TO DEVELOP THIS IN THE
FUTURE.
A FEW EXAMPLES THAT CAME FROM
THE RESEARCH REALLY DRAWING ON
THE SUCCESS STORIES OF OUR
FUNDED AWARDEES AND YOU SEE HOW
DIVERSE THIS PLATFORM IS AND SO
HERE IS A WONDERFUL EXAMPLE OF
OR ALKAN SER PAIN AND THOSE WHO
TREATED HEAD AND NECK YOU NOW
HOE THREAT EP TAG IS AND THERE'S
NOTHING LIKE IT AND NOTHING
REALLY SEEMS TO BE WORKING SO
THIS IS AN IMPORTANT MECHANISTIC
STUDY SO WE HAVE A COLLABORATION
WITH THE NATIONAL SCIENCE AND
TECHNOLOGY.
WHICH IS FEDERAL AGENCIES WE
COLLABORATE WITH LOOKING BIO COM
PAT BLEE TESTING IN A HOLISTIC
WAY AND WE ARE USING CELLS THERE
AND THEY DO SERVE THEIR PURPOSE
BECAUSE WE HAVE A PLATFORM THAT
IS STANDARDIZED AND UNIFORMLY
APPLIED.
LOOKING HERE AT SUPER STRUCTURES
OF WHAT ARE EXCITE SET OF
ROBOTIC-BASED OR DERIVED
RESEARCH FROM MICHELLE COONS'
GROUP AT THE UNIVERSITY OF
PENNSYLVANIA AND YOU CAN SEE
THAT USING SPECIFIC TOOLS AND
BEING ABLE TO REMOVE THEM
THROUGH NOT THROUGH A -- YOU USE
A BRUSH BUT IT'S USING A
DIFFERENT TECHNOLOGY THAT CAN BE
APPLIED AND TO OTHER CONDITIONS
FROM THE ORAL CAVITY.
IN THE SPACE OF OR ALKAN SER WE
HAVE NOW WHAT A STUDY THAT WAS
RECENTLY PUBLISHED IN JAN AND
LOOKING AT POST TREATMENT
SURVEILLANCE TIMING AND HOW
IMPORTANT THAT IS AND TO LOOK AT
THE LATEN SEE BETWEEN THE LAST
SURGERY OF THE LAST INTERVENTION
AND HOW THAT SHOULD BE STAGED IN
THROUGH THE LIFETIME OF THE
PATIENT AND LOOKING CAREFULLY AT
POST RADIO THERAPY CARRIES.
IT'S NOT JUST A DISEASE OF
CHILDHOOD, IT CAN COME UP ANY
TIME MANY OF IT'S A LIFESPAN
LONG ONE AND THE AGING
POPULATION FOR THOSE WHO
RECEIVED RADIATION THERAPY, FOR
CANCERS IT'S VERY THREATENING
WHEN DUE HAVE THAT PROTECTIVE
INFLUENCE AND SO THIS IS LOOKING
AT POST RADIO THERAPY
MAINTENANCE OF MONITORING AND
WHEN YOU HAVE A DEFICIENT
SALIVARY FLOW AND I'M GLAD THAT
WE HAVE REMOVING TOWARDS MORE
DIGITAL WORKFLOWS FOR
RECONSTRUCTING BONE USING
DIFFERENT SCAFFOLD IN THIS CASE
IT WAS PHOSPHATE AND OSTEO INC
PUBLISHED BY DONEL KIGLER AND
THEY HAVE APPLICATIONS FOR WHAT
WE DO IN DENTISTRY.
I WAS VERY STRUCK BY THE LEVEL
OF SUPPORT IN STATES LIKE NEW
YORK AND IN CALIFORNIA FOR THE
SPECIAL NEEDS' POPULATION.
THOSE WHO ARE INTELLECTUALLY OR
MENTALLY DISABLED.
THERE'S A WHOLE ARRAY OF SPECIAL
NEEDS' PATIENTS WHERE YOU HAVE
CONDITIONS OF MULTIPLE
SCLEROSIS, CEREBRAL PALSY AND
CHILDREN THAT PARTICULARLY IT'S
CHALLENGING AND IT'S NOT EASY TO
ACCESS CARE AND VERY OFTEN THE
CARE OR CARE TAKERS ARE NOT
TRAINED IN ORAL HEALTH NEEDS AND
THEY'RE MODULES BEING DEVELOPED
AND IT'S A HIGH LEVEL OF
TURNOVER AND SO I WAS VERY HAPPY
TO SEE THAT WE HAVE THE STUDY
OUT THERE TALKING ABOUT HOW
AUTISTIC AND NON AUTISTIC LATINO
CHILDREN RESPOND TO ORAL HYGIENE
EDUCATION AND WE ARE OPEN TO THE
NEEDS AND APPLICATIONS THAT YOU
WILL BRING TO COUNCIL FOR OUR
ATTENTION.
JUST TO REMIND YOU THAT
SEPTEMBER IS WHEN YOUR SKULL
FUSES TO ARTICLE AND YOUR BRAIN
IS GROWING AT THE SAME TIME AND
YOU HAVE CHILDREN BORN WITH THIS
DUE TO SINGLE LOSS OF FUNCTION
OR GAIN OF FUNCTION MUTATIONS IN
TWISTS OR FJRF2 AND IT'S
THREATENING BECAUSE THESE KIDS
HAVE TO UNDERGO SERIES OF
SURGERIES AND THEY ARE TYPICALLY
IT'S OBVIOUSLY EXPOSING THE
BRAIN AND COMING THROUGH THE
SKULL AND REPOSITIONING THE CAL
VAR WHY SOCALLIA AND WE NEED TON
THE FUTURE TO DEVELOP IF IT'S A
SINGLE GENE BASE AND TO KICK A
SIGNALING PATHWAY INTO ACTION TO
PREVENT THIS FROM HAPPENING.
YOU'VE HEARD FROM LYNN, OF
COURSE, WHO IS RUNNING COUNCIL
AND ANISA BROWN, JUST FABULOUS
TO HAVE HER ON BOARD WITH HER
EXPERTISE AND WISDOM AND
MATURITY BUT BELINDA HAUSER JURY
ENERGY AND CARE THROUGH THESE
PROGRAMS HAS BENEFITED NIDCR.
A SHOUT OUT TO AADOCR WHO IS ONE
OF OUR GRANTEES FOR THIS MIND
THE FUTURE, THE GRANTEE ALONG
WITH DAVID DRAKE AND EFFIE FROM
CONNECTICUT AS CHIEF OR PIs
AND RECRUIT INTERESTING ACROSS
OUR COUNTRY, EARLY-STAGE FACULTY
MEMBERS, SOME HAVE FORMAL
RESEARCH EXPERIENCE AND SOME
DON'T BUT THEY'RE OUT THERE AND
THEY GET MEN FORW MENTORED AND %
HAVE AN NIH GRANT.
SO VERY PLEASED WITH THIS OUT
AND WELCOME TO CLASS OF 2022-23.
YOU CAN SEE THESE ARE OUR FUTURE
ORAL HEALTH SCIENCE AND I WANT
EACH OF YOU TO KNOW YOUR VALUED
AND YOU ARE TREASURED ACTUALLY
AND YOU ARE MOST PRECIOUS
INVESTMENTS AND WE HOPE YOU STAY
TRUE TO COURSE AND KEEP ON YOUR
PATH TO SUCCESS.
THIS IS A SLIDE THAT DESCRIBES
THE PROGRAMS THAT BELINDA
MANAGES FOR THE DIVISION OF
INTRAMURAL RESEARCH.
THERE ARE SUMMER INTERNSHIP
PROGRAMS AND IT ENCOURAGES
STUDENTS.
YOU WOULD BE SURPRISED.
THEY TOOK A BREAK IN THE SUMMER
OR CAME FROM A YEAR TO NIDCR, IT
CAN BE TRANSFORMATIVE FOR THEIR
LIVES.
BECAUSE THEY'RE IMMERSED IN A
INTELLECTUAL RIGOROUS
ENVIRONMENT.
YOU CAN SEE IT GOES ALL THE WAY
TO CARE WARDS, CAREER TRANSITION
WARDS.
HERE IS OUR GROUP OF SUMMER
TRAINEES AND I HAD A CHANCE TO
VIEW THEIR POSTERS.
EACH ONE IS BRIGHT AND ENGAGING.
SOME ARE DDSs AND SOME ARE
DDP-PH.D AND SOME ARE PRE DICK
DOCTORAL.
OUR NEW PROGRAM ON MENTORING AND
DIVERSITY HAS YIELDED A REALLY A
STRONG SET OF FELLOWS WHO ARE
NOVAK TIVE IN LABS AND IN THE
INTRAMURAL PROGRAM AND THANK YOU
FOR CARING FOR THEM.
WE ARE FOCUSED ON TRAINING THAT
DELIVER DENTAL PUBLIC-HEALTH
SPECIFIC KNOWLEDGE BECAUSE OUR
TRAINEES ARE ENCOURAGED TO HAVE
MPHs THEY COME WITH
PUBLIC-HEALTH IN GENERAL AND
THEY'RE GIVEN ORAL
HEALTH-SPECIFIC INFORMATION AND
THEY ROTATE THROUGH CDC AND HRSA
AND VIRGINIA STATE DENTAL IN ALL
THESE NON PROFITS AVAILABLE SO
THEY GET A CHANCE TO EXPERIENCE
THAT SIDE AND THEY'LL DO TWO
YEARS OF A POSTDOC BASED
RESEARCH WITH A ANOTHER
INSTITUTE OR OR OWN DEALING WITH
THE EMERGING AREAS OF NEED FOR
WHICH GOUGH NEED DATA AND WE DO
NEED THE EVIDENCE AND WHETHER
IT'S CMSs OR WE DO NEED THESE
INDIVIDUALS TO GO OUT INTO THE
WORLD AS THOUGHT LEADERS FOR
PUBLIC-HEALTH.
DENTISTRY OR ORAL HEALTH AND I
WANTED THIS TO ACTUALLY SERVE AS
THE MODEL FOR OTHER
PUBLIC-HEALTH PROGRAMS -- IT'S
FINE BUT WE DO NEED TO KNOW, TO
UNDERSTAND THAT OUR ROLE IN
PUBLIC-HEALTH IS SO IMPORTANT
FOR OUR NATION.
SO I'M HOPING THAT THIS SERVES
AS A MODEL OF SUCCESS.
WE ARE PREPARING TO CELEBRATE
OUR 75th, NO FLASHY GALAS,
JUST RECOGNITION OF WHO WE ARE,
WHY WE WERE CREATED 75 YEARS AGO
BY HARRY TRUEMAN, DRIVEN BY THE
NEED TO TAKE CARE APPEARING TO
RAVAGE THE MOUTHS OF YOUNG MEN
WHO FAILED TO GET RECRUITED TO
THE CAR AND HE FELT THE NEED FOR
AN INSTITUTE THAT WOULD CARE
ABOUT THAT PUBLIC-HEALTH CRISIS
IN HIS TERMS.
WE'VE STAYED TRUE TO THAT COURSE
IN 75 YEARS AND NOW WE LOOK TO
THE FUTURE SO THE WHOLE
CELEBRATION IS GOING TO BE
FUTURISTIC, IT'S GOING TO BE,
WHAT DO WE WANT TO BE 25 YEARS
FROM NOW?
WHAT DO WE WANT ANOTHER REPORT
ON THE ORAL HEALTH IN AMERICA TO
TELL US?
THAT WE MADE PROGRESS?
SO WE'RE DOING ALL OF THESE
THINGS AND IT'S JUST A SKETCH ON
ALL THE DETAILS AND UNFOLD AND
I'M SO GRATEFUL THAT IT IS A
TEAM-APPROACH.
I JUST SAT BACK AND LET THE
MAGIC UNFOLD AND WE'VE GOT SAY
PAST DIRECTORS, WE HAVE OTHER
LEADERS OF NIDCR AND NIH
PARTICIPATING WITH SUCH
EXPERTISE.
JIM LIPTON, I'M HAPPY TO HAVE
THEM AND TO HAVE OUR CURRENT
STAFFERS, WHICH IS PLANNING
THIS.
WE'LL KICK IT OFF IN '23 IN
PORTLAND BECAUSE THAT'S THE
FORUM WE HAVE AVAILABLE WITH A
NICE SYMPOSIUM THAT LOOKS AT THE
FUTURE AND IT'S GOING TO BE
DELIVERED BY OUR PAST DIRECTORS
AND MYSELF.
THEN WE'LL HAVE -- WE'LL KICKOFF
THE YEAR WITH A SYMPOSIUM AGAIN
HOPEFULLY WITH ONE OF OUR NEW
NOBEL LAUREATES AND LARRY
MCCAULEY IS A SPEAKER FOR THAT
ONE AND JUST RECOGNIZING OUR
STAFFERS FOR THEIR DISTINGUISHED
SERVICES AND THEN THIS AS I
MENTIONED BEFORE, A DEDICATED
SEMINAR OR SYMPOSIUM TO
CELEBRATE 25 YEARS OF RESEARCH
THAT HAS COME FROM THE MIKE
COLLINS' GROUP.
IT'S HELD ANOTHER TIME, TRAINING
AND CAREER DEVELOPMENT WILL BE
THE FLAGSHIP ACTIVITY BECAUSE
THAT IS THE FUTURE.
350 ODD TRAINEES WILL COME TO
OUR CAMPUS WITH THEIR MENTORS
HOPEFULLY AND DIRECTORS OF
PROGRAMS AND PERHAPS DEANS TO
LISTEN TO ENGAGE AND TO SHOWCASE
THE SCIENCE AND SUCCESS AND
WE'RE PLANNING THAT WITH A LOT
OF DEDICATION AND RESOLVE SO
THAT IS THE HIGHLIGHT AND THE
FLAGSHIP AND WE'LL END THE YEAR
WITH THE SYMPOSIUM IN NEW
ORLEANS AND NOW THERE ARE THEY
WILL FOLLOW THE THEMES FOR THE
INFORM AND ALWAYS ATTRACTED TO
THE SCIENCE THAT WE PRODUCE AND
THE SCIENCE THAT WE HOPE TO
PRODUCE SO WHERE THE PROGRESS
HAS BEEN MADE WHETHER THE
CHALLENGES LIE AND OUR PATH
FORWARD AND THAT WOULD BE THE
THEME FOR THAT PARTICULAR SET OF
VINIERS AND WE'LL HEAR FROM
COUNCIL MEMBERS THEIR THOUGHTS
OF COMING UP WITH INTEGRATIVE
THEMES OF OF EDITORIALS THAT GO
OUT TO OUR STAKEHOLDER GROUPS,
KIND OF SAYING, WELCOME, COME ON
IN AND HERE IS THE PARTNERSHIP
THAT BEGINS AND I MEAN IT'S
ALREADY THERE BUT IT WOULD BE
ONE STRENGTHENING IT AND MAKING
IT APPLICABLE TO THE FUTURE.
SO HERE I AM, NOT HAVING DONE
VERY MUCH MORE THAN RELY ON THIS
AMAZING TEAM OF STAFF WHOSE
DEDICATION AND COMMITMENT
THROUGH THIS HARD TIMES HAS BEEN
REALLY OUTSTANDING.
FOR ME MAKING IT TRULY AN HONOR
AND A PRIVILEGE TO BE HERE
EVERYDAY, LOOKING FORWARD TO 25
YEARS, LOOKING FORWARD TO NEXT
YEAR AND THE NEXT MONTH WITH A
LOT OF ENTHUSIASM AND CARE FOR
THIS INSTITUTE AND ALL THAT WE
ARE RESPONSIBLE FOR.
SO, DO STAY ENGAGE, TALK TO YOUR
INDIVIDUAL CONSTITUENTS AND YOUR
ECOSYSTEM AND HELP THEM ACTUALLY
COME ON BOARD BY LISTENING TO
THIS, LISTENING TO COUNCIL
RECORDINGS AND PARTICIPATING
MORE ACTIVELY.
BECAUSE WE NEED YOU.
WE CAN'T JUST DO THIS ON OUR
OWN.
THANK YOU, AGAIN, AND NOW IT'S
MY GREAT PLEASURE TO INTRODUCE
AMAZING SLATE OF SPEAKERS.
BOB CARTER, WHO FOR ME WAS A
FONT OF VIS D WISDOM.
WE WORKED CLOSELY IN SUITE OF
OUR MUSS CUE LOWSKELETAL AND HE
HAS REALLY WEALTH OF EXPERIENCEN
THE AREA OF AUTOIMMUNE DISORDERS
THAT WE ARE BENEFITING FROM SO
BOB WILL TALK TO US ABOUT
LESSONS LEARNED, FROM AN
INITIATIVE CALLED BACKPACK WHICH
IS BROAD BACK PAIN WHICH
UNDOUBTEDLY ALL OF US ARE
SUFFERING FROM THROUGH THESE
ZOOM SESSIONS AND MANY OF THE
PIECES OF ADVICE HE CAN SHARE
WITH US AND WORE GRATEFUL TO
HAVE YOU HERE.
WELCOME BACK, AXEL.
YOU HEADING THIS SPECIAL WORKING
GROUP FOR US IS A VERY IMPORTANT
CONTRIBUTION AND IT'S AN AREA
THAT WE ARE DEEPLY COMMITTED TO
AND IT'S AN EXPENSIVE
INVESTMENT.
DATA SCIENCE SO WE WANT TO BE
WISE AND STRATEGIC AND WHAT YOU
SHARE WITH US THROUGH THE YEAR,
ON PROGRESS MADE BY YOUR GROUP
IS GOING TO BE CRITICAL IN HOW
WE SHAPE THE OFFICE LED BY JOHN
PRUGH AND Dr. LIEU WANG AT
NIDCR.
WE HAVE DANA GRAVES WHO IS SUCH
A FAMILIAR FACE AND EXPERT FOR
OUR FIELD.
BEING A ROLE MODEL, MENTOR AND
LEADER FOR ORAL HEALTH RESEARCH
BASED AT PENN AND DANA IS
HEADING THE WORKING GROUP
LOOKING AT HOW WE DO THINGS
DIFFERENTLY IN TRAINING OUR
CLINICIAN SCIENTISTS FOR THE
FUTURE AND LOOKING AT WHETHER
THE DDS DHB IS GIVING US THE
RETURN OF INVESTMENT AND IF NOT
WHAT WE CAN DO TO SHAPE IT FOR
THE FUTURE.
SO DANA, THANK YOU FOR ACCEPTING
THAT.
AND THEN NOT BY ANY MEANS THE
LEAST IS BRUCE DONOFF WHO I HAVE
KNOWN FOR YEARS AND I HAVE NOT
MET ANY INDIVIDUAL WHO CARES AS
DEEPLY ABOUT OUR PROFESSION AS
BRUCE, ABOUT ORAL HEALTHCARE FOR
ALL.
IT WAS BRUTE THAT GOT ME SET UP
FOR THE NEW ENGLAND JOURNAL OF
MEDICINE PERSPECTIVE ARTICLE AND
HE IS IN ADDITION TO SERVING AS
DEAN OF HARVARD, THE LONGEST
STANDING DEAN FOR 28 OR 30
YEARS, BRUCE HAS BEEN A PERSON
OF MENTOR AND FRIEND TO ME OVER
THE YEARS AND IS VERY KEEN ON
SHARING HIS THOUGHTS THAT ARE
GROWN OUT OF HIS YEARS OF
INTERACTING WITH THE HARVARD
SCHOOL OF MEDICINE AS AN ORAL
SURGEON AND WE HOPE TO LEARN
FROM YOU, BRUCE, ABOUT THIS --
IT MAY SOUND RADICAL TO COME BUT
IT'S A WISE PLATFORM TO BE ON.
SO THANK YOU FOR BEING HERE AND
ALL OF YOU AND I WILL NOW END BY
GETTING OUT OF MY POWERPOINT.
SHARE SCREEN.
THANK YOU.
ARE THERE ANY QUESTIONS?
THERE ARE SOME.
THAT'S NICE.
IT WAS JUST MANY THANK YOUS.
IF THERE ARE QUESTIONS, FEEL
FREE TO ANSWER THEM.
YOU DO HAVE A CHATBOX FOR THOSE
THAT ARE NOT LISTED IN THIS
GROUP OF PARTICIPANTS.
WE WILL TAKE THE TIME TO ANSWER
YOU.
BECAUSE YOUR NAME OR YOUR
IDENTIFY WOULD BE UP THERE.
THANK YOU.
>> Lynn M. King: ARE THERE ANY
QUESTIONS OR COMMENTS FOR RENA?
>> I EXPECT SOME FROM THE
NEWCOMERS.
>> Lynn M. King: ANYONE?
DID ANYTHING RAISE QUESTIONS IN
TERMS IF I WASN'T CLEAR ENOUGH
OR DIDN'T COVER POINTS WELL
ENOUGH, ANYTHING LIKE THAT JUST
LET ME KNOW.
>> TERRY, ANYTHING THAT EXCITED
YOU?
>> YOUR AUDIO IS OFF.
>> Lynn M. King: UNMUTE
YOURSELF.
>> LIKE NEVER BEFORE.
THEY'RE GOING TO FUND THOSE THAT
FOSTER TA TEAM SCIENCE.
HOW THE CULTURE CHANGES AND
ACADEMIA AND HOW IT'S REWARDED
FOR TENURE, WE CAN GET INTO THAT
BUSINESS AND I HOPE IT HAPPENS
AT THE SAME TIME.
>> I HAD IN MIND SOMETHING LIKE
AN RFA.
NOT NECESSARILY A NEW MECHANISM
BUT BY HAVING AN RFA, YOU CAN
BRING REVIEWERS WHO ARE SIMBA
NET TICK TO THAT CONCEPT AND YOU
CAN HAVE HAD AS A FOCUS.
I THROW IT OUT AS SOMETHING TO
SPEAK ABOUT.
>> I INVITE LYNN TO COMMENT AS
WELL.
I WILL SAY RIGHT OFF THE TOP, WE
DON'T HAVE CRITICAL MASS OF
EXPERTISE IN OUR SCIENCES PEER
REVIEW TENDS TO BE NOT AS
REWARDING TO ORAL HEALTH RELATED
PROJECTS AS IT COULD BE.
WE HAVE TO CREATE TA PATHWAY FOR
INDIVIDUALS TO BE REPRESENTED IN
PEOPLE.
>> THANK YOU FOR POSTING THE
COMMENTS.
SO, DANA, YOU WOULD BE, I HOPE
YOU WOULD BE PLEASED TO HEAR THE
FIRST CONCEPT IN THE CLEARANCE
AT ABOUT 1:25 THIS AFTERNOON.
IT IS A CONCEPT TO EMPHASIS
COLLABORATIVE SCIENCE, TO BRING
UPON DIS REPRESENTATIVE
TECHNOLOGIES AND NEW KNOWLEDGE
TO A FIELD THAT MIGHT HAVE NOT
BEEN PROCESSING AS FAST AS WE
WANT IT TO.
SO STAY TUNED.
>> YES.
THANK YOU, LILLIAN.
>> I JUST WANTED TO TELL YOU
THAT FRANKLY I WAS OVERWHELMED.
I HAD NO IDEA THAT ALL THIS
STUFF GOES ON WITH NIDCR AND
MAYBE THAT'S SOMETHING THAT
NEEDS TO BE CHANGED.
I THINK THE PRACTICING COMMUNITY
NEEDS TO BE AWARE OF ALL OF THE
THINGS THAT NIDCR DOES.
I MEAN, IT'S JUST BLOWING AWAY,
IT'S AMAZING.
>> I'M GOING TO TRY -- IT'S
NEVER TO SHOWCASE AS MUCH AS IT
IS TO INVITE.
THANK YOU.
FOR US IT MEANS THAT THERE'S --
WE NED TO DO MORE IN THE AREA OF
COMMUNICATION.
THANK YOU.
WE CAN MOVE ON, BECAUSE I CAN
ADDRESS THE OTHER CONCEPTS, OR
THE OTHER QUESTIONS AS THEY
ARISE.
>> Lynn M. King: THAT SOUNDS
GOOD.
SO THE NEXT IS Dr. ROBERT
CARTER FROM THE NATIONAL
INSTITUTE OF ARTHRITIS AND
MUSCULO SKELETAL DISEASES.
>> GOOD MORNING AND THANK YOU, I
REALLY ENJOYED BEING HERE AND
CAUGHT THE END OF THAT
CONVERSATION AND THIS IS QUITE
GERMANE.
WHEN WE TALK ABOUT OUR
APPROACHES TO COMPLEX DISEASES
AND PARTICULARLY BECAUSE WE'VE
HAD THE CHANCE TO WORK WITH
NIDCR ON THESE IN TWO DIFFERENT
CASE AND I'M GOING TO GO BEYOND
PACK BACK BUT THE POINT IS TO
LESSONS LEARNED OF HOW WE PUT
TOGETHER GROUPS TO TACKLE THESE
COMPLEX PROBLEMS AND I DO NEED
TO START THE ROT, RPG REMAINS
THE BETTER ACTIVE NIH FUNDING
RESEARCH BECAUSE INDIVIDUALS
DRIVE INNOVATIONS AND I DO WANT
TO MADE AND YOU HAVE TO BRING
MORE THAN ONE DISCIPLINE INTO
PLAY TO UNDERSTAND THEM AND
UNLESS IT TAKES A TEAM TO TACKLE
THE COMPLEX PROBLEMS AND THAT IS
THE FOCUS FOR TODAY, NEXT SLIDE.
SO WE'LL START WITH BACKPACK AND
I DON'T BEYOND THAT.
THIS IS ONE THAT I THINK YOU
WILL SEE SOME PARALLELS BETWEEN
SOME OF THE ISSUES THAT YOU HAVE
DEALT WITH AND PARTICULARLY
DISORDERS.
BACKPACK IS A CONSORTIUM IN THIS
DOES GET TO THE QUESTION ABOUT
RFAs BECAUSE IT'S VERY
IMPORTANT THAT YOU PUT TOGETHER
A NETWORK NOT JUST INDIVIDUAL
INVESTIGATORS, WHO COME FROM
DIFFERENT PERSPECTIVES.
FOR BACPAC IT'S THE INTEGRATED
MODEL OF LOW BACK PAIN, THE
TRANSLATION ALF TRANSLATION AL S
THAT BEST -- TO WHICH THEY WILL
RESPOND BEST WHICH YOU KNOW
ABOUT THEIR PHENOTYPE IN THE
CYCLE SOCIAL CONTEXT.
SO THE STRUCTURE FOR BACPAC THAT
PULSE DATA FROM THE DIFFERENT
SITES.
THERE'S A DOCK TECHNOLOGY SIT
SITES -- THERE ARE THREE
MECHANISTIC RESEARCH CENTERS.
THESE BRING DIFFERENT
PERSPECTIVES TO BACK PAIN, ONE
AT UCSF IS FOCUSED ON THE
INPLAIN AND ONE AT MICHIGAN
FOCUSED ON CENTRAL MECHANISMS OF
PAIN AND PAIN PROCESSING, AND
THE THIRD IS PITTSBURG FOCUSED
ON CLINICAL TREATMENT IN
OUTCOMES OF PATIENTS WITH
CHRONIC LOW BACK PAIN.
SO, IT DOES TAKE A GROUP OF
INDIVIDUALS WITH DIFFERENT
EXPERTISE TO COME TOGETHER IN
THE NETWORK.
AND IT WAS ALLUDED TO THE RFA
ACTUALLY IS A SEPARATE REVIEW
PROCESS FROM THE USUAL RO1s
AND IN THE SELECTING SITES TO
FUND IT'S NOT ABOUT WHO SCORES
THE BEST, IT'S ABOUT WHO IS
GOING TO CONTRIBUTE THE MOST TO
THE NETWORK AND WHAT YOUR GOAL
IS, IS A NETWORK WHERE THE
OUTPUT IS CONSIDERABLY MORE THAN
THE SUM OF THE INDIVIDUAL
CENTERS THAT YOU FUND.
NIH HAS TO NOT SURE TO ENSURE FK
TOGETHER.
IT ISN'T EASY, SOMETIMES IT
TAKES BLOOD AND TEARS.
BUT I WOULD SAY WE GENERALLY GET
THERE IN ALL CASES.
I'M GOING TO SPEAK QUICKLY ABOUT
A CO-OPERATIVE CLINICAL TRIAL
WITH THE GROUP IS DOING ACROSS
THE NETWORK.
SO FIRST, I'M GOING TO FOCUS ON
THIS THEORETICAL MODEL OF LOW
BACK PAIN.
IN THIS TAKES JUST THE PARTS OF
THE BODY THAT ARE FOCUSING OF
LOW BACK PAIN ON THE BOTTOM OF
THE THINGS THAT HAPPEN IN THE
SPINE.
THE DIFFERENT COMPONENTS OF THE
SPINE THAT CONTRIBUTE TO THE
PAIN.
IN THE MIDDLE IS THE
TRANSMISSION OF THE SIGNALS FROM
THIS LOCAL STRUCTURES IN THE
SPINE THROUGH THE SPINAL CORD
AND THE TOP IS THE PROCESSING OF
PAIN IN THE CNS.
SOME OF THIS IS SPECIFIC TO LOW
BACK PAIN AND A LOT OF IT
ACTUALLY COULD BE USED FOR
ALMOST ANY DISEASE WHERE THIS IS
PERIPHERAL PAIN MECHANISM OR
EVEN A TMD PAIN MECHANISM, IN
THE TRY AGAINERRAL GANGLION FOR
DOR SAL GANGLIA.
IT'S COMPLICATED ENOUGH, ALL THE
DIFFERENT PARTS AND
UNDERSTANDING THEM.
THE RESPONSE TO PAIN AND
RESPONSE TO INTERVENTIONS TO
REDUCE PAIN, ARE HUGELY
INFLUENCED BY A NUMBER OF
FACTORS BEYOND WHAT IS HAPPENING
IN THE LOCAL STRUCTURES OR IN
THE CENTRAL PROCESSING.
AND YOU CAN SEE ALL THE
DIFFERENT BOXES HERE THAT
OUTLINE THOSE DIFFERENT FACTORS
OUTSIDE OF THE PERSON THAT CAN
CONTRIBUTE TO THE EXPERIENCE OF
PAIN.
THE CRUCIAL FACT IN BOTH THIS
SLIDE AND THE ONE BEFORE, WE ARE
POPULATING THESE BOXES WITH DATA
DRAWING ON PREVIOUS PATIENTS
PHENOTYPE FOR OTHER LOW BACK
PAIN AS WELL AS THE OTHERS WHO
RECRUITED WITHIN BACPAC SO WE
CAN PUT NUMBERS ON THESE DIFFERT
BOXES ON SECESSION OF PAIN AND
THE OUTCOMES OF INTERVENTIONS ON
PATIENTS.
AGAIN, IF YOU TAKE A LOOK AT
THIS, PRETTY MUCH EVERY ONE OF
THESE BOXES CAN BE QUITE
IMPACTED AND SIMILAR TO SAY TMD.
THIS MODEL IS GENERALIZABLE.
THERE ARE A FEW THINGS THAT ARE
DIFFERENT.
THE FEMALE PREDOMINANCE SO THERE
ARE OTHER ISSUES AND I THINK
THIS TYPE OF EXERCISE OF
UNDERSTANDING AS BEST YOU CAN
THE DIFFERENT FACTORS THAT
IMPORTANT TO CONTRIBUTORS OF
PAIN, QUANTITYTATIVE THROUGH
BIG-DATA EFFORTS AND USING IT AS
A PREDICTIVE MODEL IS PART OF
THE FUTURE.
THE OTHER THING I WANT TODAY
TOUCH ON WAS THIS CO-OPERATIVE
CLINICAL TRIAL.
SO IT'S A VERY BROAD, VERY FEW
EXCLUSION FOR PATIENTS WITH
CHRONIC LOW BACK PAIN AND THIS
IS INITIAL RANDOM NATION TO ONE
OF FOUR DIFFERENT INTERVENTIONS
THAT ARE DIFFERENT AND AT 12
WEEKS, WHICH ACTS AS THE INITIAL
RANDOMIZATION, THE PATIENTS ARE
SEEN AGAIN.
IT'S INTERESTING THE DESIGN HERE
IS THAT IF THE PATIENTS ARE
DOING WELL, THEY CAN CONTINUE ON
WHATEVER THE INITIAL
RANDOMIZATION WAS.
THEY'RE DOING OK BUT NOT QUITE
WHERE YOU WANT.
YOU CAN ADD AN INTERVENTION.
OR IF THE PATIENT IS REALLY
HAVEN'T BENEFITED, DROP THE
INITIAL INTERVENTION AND MOVE ON
TO A DIFFERENT ONE.
SO YOU CAN GET BOTH DATA ON THE
IMPACT OF SEQUENTIAL
INTERVENTIONS AS WELL AS
MULTIPLE INTERVENTIONS INCLUDING
ADDING OBJECT SUBTRACTING SO
IT'S DIFFERENT THAN THE USUAL
CLINICAL TRIAL.
IN THE CRITICAL POINT THIS IS
NOT POWERED TO UNDERSTAND WHAT
IS BEST FOR THE POPULATION.
IT'S POWERED TO WE CAN DETECT A
DIFFERENCE IN OUTCOME, ON THE
INTERVENTION BASED ON THE
PATIENT'S PRESENTING PHENOTYPE.
IT REQUIRES MODELING TO
DETERMINE THE TYPES OF PATIENTS
WHO RESPOND BEST TO WHICH
TREATMENTS SO A VERY DIFFERENT
TYPE OF APPROACH TO A COMPLEX,
CLINICAL PROBLEM WITH ALL THOSE
DIFFERENT COMPONENTS THAT GO
INTO IT.
THE NEXT ARE TO ALLOW TREATMENT
FOR OUTCOME.
GOING ON BEHIND THAT ARE ALL THE
MECHANISTIC STUDIES SO WE CAN
UNDERSTAND HOW THE PATIENT
PHENOTYPE IS LINKED TO THE
MECHANISMS IN THE BODY TO
CONTRIBUTE TO PAIN AND USE THOSE
TO UNDERSTAND THE TRANSLATION TO
BLOCK THOSE MECHANISMS OF PAIN
TO IMPROVE OUTCOMES IN THE LONG
RUN.
SO THE SECOND INITIATIVE I'D
LIKE TO DESCRIBE TO DO TODAY
THAT WE HAVE UNDERTAKEN JOINTLY
WITH NIDCR WITH RENA'S
LEADERSHIP IS REJOIN.
THE ACRONYM COMES OUT OF
RESTORING JOINT HEALTH.
THE CONCEPT HERE IS WE SHOULD
TAKE THE JOINT AS A WHOLE ORGAN.
THAT WE CAN'T JUST CONSIDER SAY
THE CARTILAGE AND UNDERSTAND
OSTEO ARTHRITIS.
SO THE NEXT SLIDE -- WE TAKE ALL
THOSE DIFFERENT COMPONENTS AND
THIS DOESN'T HAVE TO BE SOME
NICHE HERE AND THIS COULD BE
OTHER JOINTS YOU WITH PICK YOUR
FAVORITE ONE INCLUDING THE TMJ
AND WE ASCERTAIN WHAT IS
HAPPENING IN THOSE DIFFERENT
TISSUES ACROSS ALL THOSE
DIFFERENT THINGS AND THE CONCEPT
IS THE DIFFERENT TYPES OF PAIN
COMING OUT OF DIFFERENT TYPES OF
MCCAINAL INJURIES AND WILL
RESULT IN INJURIES FOR THESE
DIFFERENT COMPONENTS AND THEY
MANIFEST DIFFERENTLY IN TERMS OF
SYMPTOMS AND IMPORTANTLY HELP
DETERMINE WHICH INTERVENTIONS
TARGETED WHICH TISSUE WILL MOST
HELP THAT GIVEN PATIENT.
THE YOU WILL MALT ULTIMATE GOALD
TO TISSUE DAMAGE WHETHER IT'S IN
THE TMD OR THE SPINE OR KNEE OR
WHAT HAVE YOU.
AS A FIRST STEP WE'RE DOING IN
REJOIN IS SHOWN BEFORE THE
ARCTIC YOU LAR TISSUE IS
STUDYING WHICH NERVES ARE
PRESENT IN THOSE TISSUE AND
WHETHER THEY DIFFER BETWEEN
INDIVIDUALS AND THE
HYPOTHESIS IS THERE ARE
DIFFERENT NOI NERVES THAT MAKE P
THE JOINT AND THEY'RE
RESPONSIBLE FOR THE DIFFERENT
PAIN I DESCRIBED.
IN ADDITION, WITH WE KNOW WHAT
TYPES OF NERVES ARE THERE, WE
KNOW AND FROM THE EXPRESSION
PROFILES OF THOSE TYPES OF
NERVES, WHAT MEDIATORS ARE
ACTIVATING THEM, WE CAN THEN USE
THEM TO BLOCK THOSE TYPES OF
ACTIVATION AND REDUCE PAIN SO
LONG-TERM GOAL OF RESTORING
JOINT HEALTH BY CONSIDERING THE
PERSON AND THE JOINTS AS WHOLE
THINGS, WITH FOCUS ON INITIALLY
FOR THE NERVES.
WE EXPECT THESE NOTICE OF WORDS
TO GO OUT IN THERE'S MORE NEWS
TO FINDMENT TURNING TO THE
ACCELERATING MEDICINE
PARTNERSHIP THAT WE ALLUDED TO
AND I HAVE BEEN WATCHING THIS
FOR OVER A DECADE WHICH HAS BEEN
MY PLEASURE.
IT'S A PARTNERSHIP MADE UP OF
BOTH OF NIH AND INDUSTRY AND
ADVOCACY GROUPS.
IT WAS STARTED WHEN FRANCIS
COLLINS WAS AT A MEETING OF THE
HEADS OF RND OF MAJOR PHARMA
COMPANIES WHO WERE NOTING THE
FACT THEY WERE HAVING FAILURES
IN THEIR PHASE 3 BILLION-DOLLAR
CLINICAL TRIALS AND THEY'RE
FAILING FOR LACK OF EFFICACY AND
WE REALLY DIDN'T UNDERSTAND THE
ROLE OF SPECIFIC TARGETS IN THIS
DISEASE AND SO SOME OF THE
THINGS THAT WE WERE TARGETING
JUST WEREN'T WORKING.
THIS STARTED WITH THREE PROJECTS
ONE OF WHICH WILL HELP LEAD IN
ARTHRITIS AND LUPUS BUT IT'S
GONE TO NINE DIFFERENT PROGRAMS
AND I'M GOING TO INTRODUCE A
PARTICULAR TENTH ONE AT THE END.
NEXT SLIDE.
SO THIS STARTED WITH THE RIN
LUPUS TO IDENTIFY TARGETS THAT
COULD BE BETTER FOR DRUG TARGETS
FOR TREATING PATIENTS BEYOND
WHAT WE CAN DO NOW.
IN THE FOCUS WHAT WAS WE CALLED
DISEASE DECONSTRUCTION.
ONE OF THE KEY THINGS THAT WE
COULD DO, WAS START GETTING
BIOPSIES OF THE TARGET TISSUE
FROM PATIENTS WITH LUPUS SO WE
DID RESEARCH BIOPSIES IN
ARTHRITIS AND WE ALSO COULD GET
FRAGMENTS OF KIDNEYS FROM
PATIENTS WHO ARE UNDERGOING
MEDICAL INDICATED KIDNEY
BIOPSIES FROM LUPUS AND WE DIS
AGGREGATE THE CELLS AND
INTERROGATE THEM WITH THE
EMERGING TECHNOLOGIES FOR SINGLE
CELL PROTEIN EXPRESSION AND THEN
MAP THE INTRA CELLULAR PATHWAYS
THAT WERE ACTIVE AND LOOK AT THE
DIFFERENT CELLS AND SUBSETS AND
THE STATE OF THE CELLS AND THEN
LOOK FOR CLINICAL CORRELATIONS
AND I HAVE TO SAY, ACTUALLY, IT
WAS REMARKABLY SUCCESSFUL AND WE
HAVE DEVELOPED INFRASTRUCTURE
FOR START GETTING TARGET TISSUE
FOR RESEARCH.
THE TISSUE IS CRITICAL IT IS
VERY DIFFERENT FOR TISSUE
INFORMED AND WE'RE ABLE TO RIDE
THE WAVY MERGING TECHNOLOGIES
AND WE WILL AND FROM DIFFERENT
TYPE OF TECHNOLOGIES NO SINGLE
AN IS THE SEES NOW WE HAVE
LAUNCHED LUPUS PROJECT CALLED
AMP AIM, THE AUTOIMMUNE AND
MEDIA DISEASES AND THIS IS BEEN
WITH NIDCR AND THEY'RE TER
TERRIFIC PARTNER SO THE FOCUS
WAS ON DECONSTRUCTION OF TAKING
THIS TISSUE, PULLING THE CELLS
OUT AND ANALYZING THE CELLS IN
ISOLATION AND THE FOCUS OF AMP
AIM WILL BE DISEASE
RECONSTRUCTION, IN OTHER WORDS,
WE KNOW WHO THE PLAYERS ARE BUT
WE NEED TO KNOW HOW THEY
INTERACT TO PUT THE PIECES BACK
TOGETHER AGAIN AND USING THE
EMERGING INSIGHTS AND
TECHNOLOGIES, NEXT SLIDE.
THIS WAS LAUNCHED A YEAR AGO AND
AND WE'VE GONE BEYOND THE
STUDIES OF ART IN LUPUS TO
INCLUDES PSORIASIS AND THIS IS
WHERE THE PARTNERSHIP HAS COME
IN.
REALLY IMPORTANT COMING OUT THE
R.A. AND LUPUS STUDIES IS
AMAZING HOW HETERO GENIOUS THE
TISSUES ARE IN A SINGLE
DIAGNOSIS.
THEY'RE ACTUALLY NEIGHBORHOODS
WITHIN TISSUE AND VERY DIFFERENT
PATHOLOGIES GOING ON.
SO, WE HAVE TO ACTUALLY ALMOST
RETHINK THESE DISEASES.
WE NEED TO UNDERSTAND HOW THE
CELL AND MOLECULAR PATH ARE
SPECIFIC TO A GIVEN DISEASE OR
COMMON ACROSS DISEASES.
DELIVERABLES ARE UNDERSTAND HOW
CELL CELL INTERACTIONS NEED TO
DISEASE THROUGH SPACIAL ANALYSIS
AND GOING BEYOND THAT TO
UNDERSTAND THE MEDIATORS THAT
THE CELLS USE TO TALK BETWEEN
THEMSELVES AND THEN INTEGRATE
ALL OF THAT WITH THE SYSTEMS
BIOLOGY APPROACH TO INTEGRATE
WHAT IS GOING ON IN THE TISSUES
WITH THE GENOMICS OF THE PERSON
AND THE EP GENETICS TO IDENTIFY
NEW TARGET MOLECULES CAUSE TIVE
FOR THE DISEASES, NEXT SLIDE.
THIS FOCUSED ON MOLECULAR
PATHWAYS.
YOU START WITH THE PERSON.
THE PERSON OF COURSE BRIDGES THE
AGAIN ET STICKS THAT THEY HAVE.
BASED ON THE INTERACTIONS OF THE
DISEASES, GENETIC DISEASE
ACTUALLY ARE EQTLs THEY MODIFY
THROUGH CHANGING EPI GENETIC
REGULATIONS AND SO BETWEEN THE
GENES AND THE ENVIRONMENT AND
THE MICROBIOME, THEY'RE CHANGES
IN THE EP DEGENETICS THAT LEAD
WHAT GETS TRANCE DESCRIBED
INSIDE THE CELLS AND THAT IS THE
THEY DICTATE WHICH PROTEINS GET
PRESSED AND WHAT THE SELL STATE
IS OF THE CELLS AND ALSO THE
MOLECULES THAT CELLS USE TO TALK
BETWEEN EACH OTHER AND THEN YOU
CAN USE SILLS TOMORROW'S BIOLOGY
APPROACH TO INTEGRATE ALL OF
THOSE THINGS TO HELP UNDERSTAND
DISEASE PHENOTYPES AND OUTCOMES
AND ALSO ASSOCIATED WITH BIO
MARK SOURCE YOU CAN UNDERSTAND
WHAT IS A PERSONS TISSUE BASED
ON THE READILY ACCESSIBLE
BIOMARKER.
IMPORTANT POINT THOUGH IS EACH
ONE OF THESE BOXES CAN BE
QUANTIFIED AND IN SOME DAYS AND
CELLS AND IF I HAD THE SAME CELL
IN THE SAME PERSON SO WE CAN NOW
INTEGRATE ACROSS THESE DIFFERENT
DOMAINS TO UNDERSTAND THE
MOLECULAR PATHWAYS THAT DRIVE
BIOLOGY.
IF LUPUS WAS ON THE LEFT SIDE,
FOCUSED ON THE CELLS USE TO TALK
TO EACH OTHER.
AND THIS DATA WILL BE AVAILABLE
IN A PORTAL THAT STOOD UP NOW
AND IT'S ACCESSIBLE TO THE
MEMBERS OF THE NETWORK AND
RESEARCH IS CONTROLLED ACCESS
AND THEY CAN INTEG GATE THE
POPULATION INTEREST AND --
THE GENES AND THE MOLECULES AND
IT SETS US UP FOR THE FUTURE.
NEXT SLIDE.
THIS CREATING DATA ECOSYSTEM
THAT NO ONE PERSON FILLS IN
THOSE BOXES BY THEMSELVES.
WE HAVE TO HAVE A DIFFERENT
EXPERTISE BROUGHT TOGETHER.
THEY CAN GO ON OUTSIDE AND THE
BEHAVIOR AND PSYCHOSOCIAL
INTERACTIONS AND IT TAKES THE
INTEGRATION ACROSS RESEARCH
TEAMS AND ACROSS ANALYTIC
PLATFORMS AND ACROSS DISEASES AS
I MENTIONED AND ACROSS AND
INSTITUTES AND CENTERS AND I
THINK NIH HAS TO MOVE AWAY FROM
THE SILOED APPROACH TO DISEASES
AND THINKING THIS THE SYSTEMS
BIOLOGY INFORMATION WHICH WE'RE
TRYING TO LAUNCH IS A NEW AMP
PROJECT FROM A CONCEPT
PRESENTATION BY SUSAN AND MYSELF
AND THROUGH THE AMP EXECUTIVE
COMMITTEE.
NEXT SLIDE.
SO, WHAT IT DOES IS TAKE ALL THE
DIFFERENT AMP PROJECTS AND ALL
BUT ONE OF THEM HAVE OMIC DATA
OF SOME SORT AND TRIED TO
INTEGRATE ACROSS SOME VERY
DIFFERENT DISEASES AND SO
DISEASES THAT WE USED TO THINK
AND IT'S COMPLETELY SEPARATE AND
ALL REST ON THE SAME SUBSTRATE,
WE KNOW THAT BECAUSE EVERYTHING
IS BASED ON OUR OWN GENOMES AND
THERE ARE QUITE SIMILAR PATHWAYS
ACTIVE IN DISEASES THAT YOU
WOULD NEVER THOUGHT OF THE SAME.
WE CAN FIND SIMILARITIES AND
FLAM TORI PATHWAYS BETWEEN
ALZHEIMER'S DISEASE AND
PARKINSON'S, RHUMATOID ARTHRITIS
AND LUPUS.
SO, IT'S A NEW WAY OF
APPROACHING THESE DISEASES.
SO WHAT IT WOULD DO IS TAKE THE
EXISTING DATASETS PRODUCED IN
ALL THE DIFFERENT AMP PROJECTS
AND USE THOSE TO INTEGRATE
ACROSS THE DISEASES USING LENS
OF INFLAMMATION AND SO THEY CAN
WE CAN DO DRUG DEVELOPMENT IN
POSITIONING OF DRUGS BASED ON
THE MECHANISM OF ACTIVE AND AN
INDIVIDUAL AND NOT ACCORDING TO
THE CLINICAL LABEL.
WE CAN USE BLOOD OMICS DATA TO
LOOK AT HOW THE SYSTEMIC
INFLAMMATION RELATES TO WHAT
HAPPENS IN TISSUES AND WE CAN
UNDERSTAND THE CONTRIBUTION OF
CHRONIC FROM MISSCRON INFLAMMATS
DISEASES AND NEXT -- AT THE END
OF THE DAY, WHAT WE WANT TO DO
IS DEVELOP A MOLECULAR TAXONOMY
OF DISEASE TO DRIVE TREATMENTS
BASED ON ACTIVE PATHWAYS IN A
GIVEN PATIENT REGARDLESS OF THE
CLINICAL DIAGNOSIS.
SO THAT IS THE BIG ASK AND WE
HOPE THAT NIDCR WILL JOIN US IN
THIS JOURNEY.
NEXT SLIDE.
THIS IS NOT PIE IN THE SKY THIS
IS THE LUPUS INVESTIGATORS WHO
CAN DEMONSTRATE A SIMILAR TYPE
OF MACROPHAGE ACROSS A RANGE OF
NOT JUST AUTOIMMUNE DISEASES BUT
EVEN IN COVID SO THIS TYPE OF
THING IS POSSIBLE AND IT IS
HAPPENING AND I THINK WE NEED
NIH JOINED TOGETHER ACROSS ICs
TO MOVE THIS APPROACH DISEASE
BEFORE AND THIS IS THE NEXT
SLIDE.
NEXT SLIDE.
SO WE HAVE A LOT TO TALK ABOUT
BETWEEN NIDCR AND HOW DOES PERRY
PER -- HOW DOES OSTEO ARTHRITIS
RESPOND TO REGENERATION.
SO THANK YOU FOR YOUR ATTENTION
AND I HOPE TO ANSWER ANY
QUESTIONS AND HOPE WE CAN
CONTINUE TO WORK TOGETHER.
THANK YOU.
>> THANK YOU, VERY MUCH.
THAT WAS AMAZING.
ARE THERE QUESTIONS FOR Dr.
CARTER.
>> THAT WAS SUCH A BROAD SWEEP
OF IN-DEPTH WORK.
CAN YOU TALK ABOUT THE
THERAPEUTICS THAT THIS WORK
ACTUALLY GAVE RISE TO,
ESPECIALLY FOR SYSTEMIC LUPUS
AND RHUMATOID ARTHRITIS?
>> THERE'S ARE A COUPLE THINGS
IN THE WORKS.
I'M GOING TO DIGRESS TO MAKE THE
POINT BECAUSE THERE ARE SEVERAL
THINGS WRAPPED UP IN THAT BUT WE
ALWAYS THOUGHT OF RA AS AN
EXPANSION OF A SET OF CELLS THAT
ARE ON THE OUTSIDE OF THE SLOGAN
LINING CELLS AND WHEN WE FOUND
WAS THAT ACTUALLY IT WASN'T
THOSE CELLS, THERE WAS A
DIFFERENT TYPE OF FIBREGLASS
UNDER THE LINING AND THOSE CELLS
EXPANDED.
THEY WERE THIGH ONE POSITIVE AND
DIFFERENT SET OF CELLS AND RARE
IN NORMAL PEOPLE WITHOUT
ARTHRITIS.
AND WHAT WE COULD DO EVENTUALLY
THE GROUP AT BRIGHAM MAPPED
THOSE TWO IN INTERACTION WITH
BLOOD STRESS VESSEL AND THOUGH
THE EXPANSION OF THE SUB LINING
FIBER BLAST AND IT CORRELATED
WITH DISEASE OUTCOMES AND
SEVERITY.
THEY WERE DEVELOPED FOR CANCER
AND I'M NOT PRIVY TO EXACTLY
WHAT IS GOING THERE BECAUSE
EVERYTHING WE DO IS PRE
COMPETITIVE BUT IT'S NOW OPENING
UP A NEW WINDOW HOW TO TREAT IT
AND THE OTHER SIDE OF THE THINGS
THE DRUG COMPANIES ARE NOT
WORKING ON AND THEY'RE NOT VERY
RARE AND RHUMATOID.
MOUSE MODELS, THINGS LIKE IL17
GET PRESS BECAUSE THEY COME OUT
OF MOUSE MODELS AND LITTLE IL17
MANY OF THERE'S SOME BUT FEW.
ACTUALLY IF YOU ASK THE INDUSTRY
THE WIG BIGGEST THING AND
THEY'VE STOPPED THE NUMBER OF
DRUG PROTOCOL DEVELOPMENT
BECAUSE THERE WASN'T EVIDENCE
AND I THINK YOU KNOW, A LOT OF
TIMES THINGS GET THINGS AS
FISHING EXPEDITIONS AND IF YOU
DID KNOW THE PLAYERS, HOW CAN
YOU COME UP WITH EFFECTIVE
TREATMENT AND THIS DISCOVERY
THING WHERE YOU PRODUCE A
DATASET AND THERE'S ONE OTHER
SITUATION WHERE SOMEONE WAS
WORKING ON A GENE AND A MOUSE
MODEL BUT DIDN'T KNOW RELEVANCE
BUT WENT IN AND FOUND IT PRESENT
IN LUPUS KIDNEY, COULD SHOW IT
IN THE CERTAIN TYPE OF CELL
WHICH MATCHED THEIR HYPOTHESIS
FROM THEIR MOUSE WORK AND GOT
HIS RO1 FUNDED.
SO, THERE'S AN IMPACT ALTHOUGH
IN TERMS OF NEW THERAPY, THERE'S
NONE THAT HAVE GOTTEN ACROSS THE
FINISH LINE YET.
>> ANY OTHER QUESTIONS?
>> THIS IS VERY EXCITING.
THANK YOU SO MUCH.
ACROSS THIS NEW INITIATIVE, THIS
CROSS CUTTING INITIATIVE WHERE
YOU ARE GOING TO LOOK AT THE
COMMONALITY WITHIN THE CHRONIC
INFLAMMATION, IT WOULD BE VERY
INTERESTING TO LOOK AT THE ROLE
OF PERRY DON TAL DISEASE BECAUSE
THEY HAVE THIS CHRONIC
INFLAMMATION AND TO -- AND IT'S
MAKING SYSTEMIC CONTRIBUTION AND
I WANTED TO SHARE THE POTENTIAL
FOR COLLABORATION.
>> THANK YOU, I AGREE.
>> ALSO, COUNTING ON YOUR
EXPERIENCES TO HELP US WITH THE
TMD WITH IMPACT BECAUSE WE HAVE
A CONDITION THAT HAS A GENDER
BIAS SO THAT'S THE FIRST UNIQUE
THING.
THE JOINT ITSELF IS UNIQUE AND
THE FIBER CARTILAGE ELEMENTS AND
IT'S ALSO UNIQUE BECAUSE WE PUT
MAXIMUM AMOUNT OF STRESS ON IT
AS COMPARED TO KNEE AND HIP.
BUT THEN YOU HAVE A BUY BIO
CYCLE SOCIAL ELEMENT.
WHICH COMES FIRST?
DOES THAT STRESS CAUSE TMD OR IS
THE CLINCHING GOING TO AGGRAVATE
AN EXISTING CONDITION.
HOW DOES ONE DISSECT OUT THIS
LOOP?
IS IT A FEEDBACK LOOP?
WHAT IS PRIMARY AND IT'S ALL
DIFFICULT BECAUSE WE HAVE THIS
BIO CYCLE SOCIAL AGENDA BIAS OF
THE AGENDA BASE FOR DIFFERENCES.
>> I AGREE.
THE CAUSAL INFERENCE IS A
PROBLEM.
STATISTICS AROUND IT ARE TOUGH.
AND IT JUST GOES TO THE
CONFOUNDERS ARE SO TOUGH.
I DO THINK THAT YOU CAN USE AI
TO UNDERSTAND PATHWAYS THAT YOU
WOULD NOT SUSPECTED BEFORE.
AND I THINK THAT'S THE HOPE
THAT, IN SOME CASES, THINGS ARE
JUST SO ENTANGLED BUT IN OTHER
CASES, BY UNDERSTANDING THE LINK
TO THE BIO PSYCHOSOCIAL TO THE
SYMPTOMS AND TO THE MOLECULAR
PATHWAYS, AT THAT POINT I THINK
CAN YOU START TO AT LEAST COME
UP WITH HYPOTHESIS OF CAUSE TIVE
AND MECHANISMS.
>> Lynn M. King: GREAT.
THANK YOU.
I THINK WE NEED TO MOVE ON TO
OUR NEXT SPEAKER.
Mr. AXLE VISEL.
HE IS A COUPLE ME COUNCILMEMBERR
OF THE DATA SCIENCE WORKING
GROUP WHICH RONA PRESENT TODAY
COUNCIL BACK IN JANUARY AND MAY
OF THIS YEAR.
I'M GOING TO TURN IT OVER TO
Dr. VISEL WHO PROVIDE AN
UPDATE AND STATUS OF THIS
WORKING GROUP.
>> WE'RE WAITING TO SEE YOUR
SLIDES, AXEL.
OR WOULD YOU LIKE NIDCR TO
PRESENT?
SHOULD WE MOVE DANA UP FOR NOW
OR JUST WAIT.
EITHER ONE.
HE HAS BEEN ON SO I DON'T KNOW
WHAT IS HAPPENING HERE.
>> WHEN WE WAIT, I WAS GOING TO
ASK DANA AND OTHERS BECAUSE YOU
KNOW AS JENNIFER MENTIONED, THE
APPLICATIONS ARE THERE.
>> GREAT.
>> TO PATIENTS.
>> YEAH.
MY COMPUTER JUST FROZE, RIGHT.
I STARTED MY PRESENTATION AND
DIDN'T DO ANYTHING FOR A MINUTE
OR SO.
I DID ADVANCE THE SLIDES.
EXTENT.
HOCKEY.
GOOD MORNING AND I'M IN THE MOOD
FOR MOST OF IT AT THAT POINT,
EVERYBODY.
SO I'M REALLY EXCITED TO GIVE
THIS UPDATE ABOUT THE DATA
SCIENCE STRATEGY WORKING GROUP.
MY NAME IS AXEL AND I'M AT
GEORGE BERKELEY NATIONAL LAB AND
I WAS APPOINTED AS THE CHAIR OF
THE WORKING GROUP AND REMINDING
EVERYBODY WHAT THESE COUNCIL
WORKING GROUPS ARE AND SO THESE
ARE GROUPS THAT ESSENTIALLY ARE
TASKED TO FOCUS ON A SPECIFIC
PROBABLE, A LIMITED PROJECT THT
I WOULD GET UNPUT ON SO THEY
SERVICE FACT-FINDING BODIES
BRINGING TOGETHER EXPERTS WITH
THE GOAL TO ASSESS THE FACT AND
PROVIDE RECOMMENDATIONS.
SOMETHING THAT IS IMPORTANT HERE
IS THESE ARE COUNCIL WORKING
GROUP SO THEY MAKE THEIR
RECOMMENDATIONS NOT DIRECTINGLY
TO NIDCR BUT TO COUNCIL AND IT
CAN THEN IN TURN USE THESE
RECOMMENDATION TO PROVIDE ADVICE
TO COUNCIL.
THERE ARE CURRENTLY THREE
COUNCIL WORKING GROUPS PLANNED
OR IN PROGRESS AND.
>> THESE APPROACHES HAVE TO BE
TRANSFORMATIVE IN MANY AREAS OF
SCIENCE THE KNOWN EXAMPLE THAT
GOT PRESS LAST YEAR THIS THIS
NEWS TO ALPHA PHOTOGRAPHIC
DEVELOPED UNDER THE GOOGLE
UMBRELLA AND A REVOLUTIONARY
TOOL THAT USED ARTIFICIAL
INTELLIGENCE TO GET SETS TO
ENABLE ACCURATE PREDICTIONS OF
C2 STRUCTURES FOR MANY PROTEINS
SO THIS IS SOMETHING THAT
STRUCTURAL BIOLOGIST HAVE BEEN
DREAMING OF FOR MANY DECADES
IT'S TRANSFORMATIVE AND CHANGING
AN ENTIRE FEET.
NOW THESE TERMS GET A LOT OF
PRESS BUT WHEN WE THINK ABOUT
DATA SCIENCE, AND THIS IS TRUE
FOR BOTH THE WAY OUR WORKING
GROUP THINKS ABOUT DATA SCIENCE
AND THE WAY NIDCR THINKS ABOUT
DATA SCIENCE IT'S IMPORTANT TO
ACKNOWLEDGE THERE'S MUCH MORE
THAN THESE FLASHY TERMS AND MANY
DATA SCIENCE AND DATA ENABLE
APPROACHES THAT ARE REALLY
IMPORTANT FOR ADVANCING THE
MISSION IN PARTICULAR AND SOME
EXAMPLES ARE SHOWN HERE ON THIS
SLIDE, RIGHT.
SO THIS INCLUDES THINGS SUCH AS
INTEGRATIVE DATA SYSTEMS AND I
THINK IN THE NIDCR SPACE IT'S
BEEN A SPECTACULARLY SUCCESSFUL
EXAMPLE OF THAT AND THE
DEVELOPMENT OF CONTROLLED FOR
VOCABULARY THAT DESCRIBE
BIOLOGICAL AND MEDICAL ENTITIES
SUCH AS GENES, ANATOMY AND
PHENOTYPES AND DIFFERENT ACCESS
TO THESE KINDS OF BIOLOGICAL
ENTITIES FOR DATA SCIENCE
APPROACHES AND AI READINESS AND
DATA ACCESS AND SHARING.
YOU MAY HAVE HEARD ABOUT THIS
PRINCIPLES THAT DESCRIBE HOW YOU
MAKE DATA FINE ABLE AND
ACCESSIBLE AND SO ON SO THEY CAN
REUSE DAYTONA AND IT'S REALLY
HARD TO DO SO AND SO DATA
ECOSYSTEMS FOR RESEARCH AND
TRAINING THESE ARE INCREASING IN
IMPORTANCE AND DIFFICULT TO
BUILD AND THEN WHEN WE THINK
ABOUT THE CLINICAL SIDE,
ELECTRONIC CLINICAL RECORDS THAT
ARE IMPORTANT FOR IMPROVING
HEALTHCARE BUT ALSO FOR USING
HEALTHCARE DATA AND ANALYZING IT
USING THESE APPROACH AND THEY
REQUIRED DATA HARMONIZATION AND
IN SOME CASES IT'S TRIVIAL AND
HARD IN PRACTICE AND THEN
FINALLY OF COURSE THIS RELATES
DIRECTLY TO ONE OTHER MAJOR
FOCUS AREA OF NIDCR ADDRESSING
DISPARITIES AND INEQUALITIES IN
HEALTHCARE AND THIS RELATES BOTH
TO ACCESS TO HEALTHCARE FOR
PATIENTS BUT ALSO, TO
DISPARITIES AND INEQUALITIES
WHEN WE THINK ABOUT OUR
EDUCATIONAL APPROACH AND ABOUT
DIVERSITY OF OUR WORKFORCE AND
SO ON AND ALL OF THESE HAVE
EXCITING OPPORTUNITIES FOR DATA
SCIENCE AND DATA ENABLED
APPROACHES TO ADVANCE THIS.
WHEN WE THINK ABOUT DATA SCIENCE
IN THE CONTEXT OF NIH AND AS THE
BACKGROUND FOR OUR WORKING
GROUP, IT'S IMPORTANT TO POINT
OUT THAT NIH AS THE OVERARCHING
UMBRELLA OF COURSE HAS
RECOGNIZED IMPORTANCE OF DATA
FOR A LONG TIME SO, IT CAME OUT
IN 2018 AND IT HIGHLIGHTS HOW
BIO MEDICINE HAS ADVANCED INTO
AN ERA WHERE MANY TYPES OF DATA
FALL UNDER THE SPHERE OF BIG
DATA AND ALONG WITH IT COMES
ENORMOUS OPPORTUNITIES.
AND THIS HAS OF COURSE SPURRED A
VARIETY OF ACTIVITIES AT NIH IN
VARIOUS IOCs AND JUST ONE
EXAMPLE THAT I RANDOMLY PUT ON
THESE IS THE DIGITAL NIH
INITIATIVE AND INNOVATION
TECHNOLOGY COMMUTATION FOR THE
FUTURE OF NIH SO THIS IS A
REPORT PRESENTED IN 2022 AND
THAT HIGHLIGHTS VARIOUS AREAS OF
ACTIVITY OVERARCHING AT NIH.
WHEN WE THINK MORE SPECIFICALLY
ABOUT NIDCR, WE ALREADY SAW THE
COVER OF THIS EXCITING STRATEGIC
VISION AND NIDCR PUBLISHED AT
LAST YEAR AND IN THIS VISION,
DATA AND DATA SCIENCE PLAYS A
BIG ROLE SUCCESSFUL PACE-BASED
AS AN WAY HOW SIGNS AND WHEN YOU
LOOK AT THIS PLAN MORE CROWSLY,
DATA AND DATA SCIENCE IS ALL
OVER THE PLACE.
AND SO, WHEN YOU LOOK AT HOW THE
STRATEGIC PLAN IS ORGANIZED SO
THIS IS ESSENTIALLY WHAT Dr.
D'SOUZA SHOWED IN HER
INTRODUCTION JUST ORGANIZE
SLIGHTLY DIFFERENTLY THERE ARE
FIVE STRATEGIC PRIORITIES.
AND WHEN YOU LOOK MORE CLOSELY,
AT THE SPECIFIC GOALS TO EACH OF
THESE STRATEGIC PRIORITIES THAT
YOU FIND IN THIS STRATEGIC PLAN,
YOU WILL FIND MANY EXAMPLES
WHERE DATA IS REALLY AN INTEGRAL
COMPONENT AND CRITICALLY NEEDED
TO ACHIEVE THESE PRIORITIES.
SO, FOR EXAMPLE, THE FIRST ONE
IS INTEGRATE AND GENERAL HEALTH
AND WE HEARD ABOUT ALL OF US
DATA EARLIER TODAY RIGHT.
INTEGRATION OF THE CONDITIONS
WITH SYSTEMIC DISEASES ASKING
ALL OF US DATA AND THE
DEVELOPMENT OF UNIQUE AND SHARED
TAXONOMY FOR THE RESEARCH AND
VOCABULARY THAT HELP US PERFORM
THIS INTEGRATION.
PRECISION DENTAL MEDICINE.
HERE, OUR DATA ECOSYSTEM NEEDS
TO BE CREATED AND EXPANDED TO
IMPROVE HEALTH OUTCOMES IN
INDIVIDUALS POPULATION AND
REMOTE TELE DENT TREE REQUIRE
NEW APPROACHES FOR CAPTURING AND
HANDLING DATA.
THE THIRD STRATEGIC PRIORITY TO
TRANSLATE AND IMPLEMENT THIS
LINKS BACK TO WHAT I MENTIONED
EARLIER, ELECTRONIC HEALTH
RECORDS.
HOW DO WE COLLECT THIS DATA AND
MAKE IT AVAILABLE ACROSS SYSTEMS
AND HOW DO WE DEVELOP THESE AND
ACTION ON MWE SEE STANDARD TECHD
STRATEGIES PRIORITY FOUR IS THE
DIVERSE RESEARCH PIPELINE HERE
AND THIS OF COURSE NEEDS TO GO
HAND AND HAND WITH TRAINING AND
CAREER DEVELOPMENT OPPORTUNITIES
AND TO BID A RESEARCH PIPELINE
AROUND DATA SCIENCE AND THEN THE
FIFTH PARTY IS PARTNERING AND
COLLABORATION.
KNOWLEDGE SHARING OF
STAKEHOLDERS AND OUTREACH AS
ENORMOUS OPPORTUNITIES THROUGH
NEW DATA-DRIVEN APPROACHES.
WITH ALL OF THIS IN MIND, TO
SUMMARIZE WHAT OUR DATA SIGNS
STRATEGIES WORKING GROUP HAS
BEEN CHARGED WITH IS AS A
DRIVER, BUILDING ON THE NIDCR
STRATEGIC PLAN WHICH PUTS FOURTH
THE VISION FOR THE FUTURE AND
RECOGNIZING THE OPPORTUNITY THAT
LIES IN DATA SCIENCE FOR
PROVIDING A NEW BIOMEDICAL
INSIGHTS AND ADVANCING THE
DEVELOPMENT AND DELIVERY OF
HEALTH SOLUTIONS.
SO, THIS SPECIFIC ASK, FOR OUR
WORKING GROUP IS TO HELP
DEVELOPED A DATA SCIENCE
STRATEGY THAT POLITICIANS ALL OL
OF THIS.
THINKING ABOUT THE GAPS AND
OPPORTUNITIES OF INTEREST.
HERE SAY FIRST SET OF GAPS OF
OPPORTUNITIES AND IN THE
INTEREST OF TIME SO THAT WE HAVE
A LITTLE BIT OF TIME FOR
DISCUSSION LATER ON, I WILL NOT
TALK ABOUT ALL OF THESE IN
DETAIL.
YOU CAN FIND THE SLIDES IN YOUR
MATERIALS.
BROADLY SPEAKING, THESE FALL
INTO THE AREAS OF EVOLVING THE
ECOSYSTEM AND APPLYING DATA AND
DATA SCIENCE METHODS AND
EMPOWERING RESEARCH AND HEALTH
DISPARITIES AND UNI QUALITY AND
SOME OF THESE MAY LOOK FORWARD
AND I THINK DID D'SOUZA SHOWED
SOME OF THESE IN A PRESENTATION
THAT SHE GAVE AT THE MAY COUNCIL
MEETING.
AND WITHOUT GOING INTO TOO MUCH
DETAIL I WANT TO POINT OUT THIS
IS A LOT OF BULLETS HERE BUT
EVEN THAT MIGHT NOT CAPTURE
EVERYTHING.
SO ONE IMPORTANT TASK FORCE FOR
OUR DATA SCIENCE STRATEGY
WORKING GROUP IS TO LOOK AT
THESE CAREFULLY AND THINK ABOUT
WHICH OF THESE ARE THE HIGHEST
PRIORITIES AND THINK ABOUT
ADDITIONAL ONCE THAT SHOULD BE
RELEVANT.
SO, IN TERMS OF THE WAY OUR
WORKING GROUP IS INTENDED TO
OPERATE, THIS IS A BUILDING ON
THIS WORKING GROUP MODEL THAT
HAS BEEN QUITE SUCCESSFULLY USED
BUY ICs AND IN SOME CASES
SPECIFICALLY AROUND THE DATA
SCIENCE AND THAT COVER THE WHOLE
SPECTRUM OF SCIENTIFIC AND
CLINICAL EXPERTISE THAT WE WANT
TO COVER AND THAT IMPORTANTLY,
COVER THE TRANSLATIONAL SPECTRUM
THAT IS COVERED BY NIDCR.
WE WANT TO BE ABLE TO ADDRESS
DATA SCIENCE NEEDS FOR ALL FIVE
NIDCR STRATEGIC AREAS.
IN THE RECOMMENDATIONS THAT WE
WOULD PROVIDE TO COUNCIL, WE
WANT TO HAVE A MIX OF BOTH SHORT
TERM WHICH MEANS IMMEDIATELY
ACTIONABLE ITEMS AS WELL AS
LONG-TERM STRATEGIC
RECOMMENDATIONS THAT CAN BE
CONSIDERED.
AND I WILL SHOW YOU IN A MOMENT
AND WE KICKED OFF THE WORKING
GROUP AND IT WAS ABOUT A YEAR
FROM NOW AND WE WILL HOLD
RECOGNIZE WORKING GROUP MEETINGS
AND POSSIBLY DEDICATED WORKSHOP
WHICH WOULD BE IN-PERSON OR
VIRTUAL AND WE WILL GIVE REGULAR
UPDATES AT NIDCR COUNCIL AND BY
MYSELF OR THE CO-CHAIR MIGHT
GIVE THEM AND THEN THE MAIN
DELIVERABLE WILL BE A FINAL
REPORT TO COUNCIL TYPICALLY
GIVEN IN A FORM OF A
PRESENTATION ALONG WITH A
DOCUMENT AND THAT SUMMARIZES
WHAT WE'RE RECOMMENDING AND
PRIORITIZES THE VARIOUS ITEMS
AND WE MAY FOLLOW IT UP AND SOME
WORKING GROUPS HAVE DONE WHICH
CAN HELP TO INCREASE THE
VISIBILITY OF THIS
RECOMMENDATIONS AND FOR THE
LARGER COMMUNITY.
SO WHERE DO WE STAND?
OF THE PAST MONTH WE'VE BEEN
WORKING HARD ON THIS SO THOSE
WORKING CLOSELY TOGETHER WITH
NIDCR STAFF WE HAVE A CHAIR
WHICH IS ME AND A CO-CHAIR AND
WE HAVE OF THE LAST MONTH OR TWO
AND WORKED WITH TO COLLABORATE
IDENTIFY CANDIDATES WHO MIGHT
SERVE ON THIS AND 12 MEMBERS
WERE SELECTED AND INVITED BY
Dr. D'SOUZA AND THEY HAVE NOW
BEEN APPOINTED SO, I'M EXCITED
THE MEMBERS OF OUR WORKING GROUP
SO WE HAVE THE 12 MEMBERS THAT
MAKE UP THE WORKING GROUP AND WE
HAVE THREE STAFF FROM NIDCR WHO
PARTICIPATED IN THESE MEETINGS,
LYNN AND JOHN AND LIEU WANG WHO
SUPPORT US IN DRIVING 24 WORKING
GROUP.
WHEN YOU LOCK AT OUR 12 MEMBERS,
YOU CAN SEE THAT THERE ARE VERY
DIVERSE BOTH IN TERMS OF THE
PEOPLE WHO ARE REPRESENTED BUT
MORE IMPORTANTLY IN THE
EXPERTISE THEY CAN CARRY.
CAN YOU SEE WE COVER A WIDE
RANGE OF SCIENTIFIC AND CLINICAL
DISCIPLINES GOING FROM THINGS
LIKE GENOMICS, MYSELF, ONCOLOGY,
MACHINE LEARNING SO BASIC
COMPUTATIONAL SCIENCE AND ALL
THE WAY THINGS SUCH AS BEHAVIOR
AND THEN IT GOES INTO CLINICAL
AND COMMUNITY RELATED ISSUES AND
HEALTH INFORMATION TECHNOLOGY
AND HEALTH EQUITY.
SO SOMETHING THAT WAS ALSO
IMPORTANT FOR US TO COVER THE
ENTIRE TRANSLATIONAL SPECTRUM.
THIS IS TYPICALLY CATEGORIZED
THAT COVER FROM BASIC RESEARCH
TO TRANSLATION TO HUMANS AND
PATIENTS FOR CLINICAL STUDIES
AND TRANSLATION AND LIMITATIONS
IN CLINICAL PRACTICE AND THEN
ALL THE WAY INTO TRANSLATION TO
COMMUNITIES.
AS WE SELECTED THE PARTICIPANTS
IN THIS WORKING GROUP, WE AIMED
TO COVER THIS SPECTRUM AND YOU
SEE HERE BASED ON
SELF-IDENTIFIED AREAS OF
COVERAGE THAT WE NICELY COVERED
THE SPECTRUM AND THIS HOPEFULLY
WOULD ENABLE US TO COME UP WITH
A SET OF RECOMMENDATIONS THAT
CARRIES ALL AREAS OF SCIENTIFIC
AND CLINICAL EXPERTISE BY ALSO
COVERING ALL ASPECTS OF
DEVELOPING BASIC RESEARCH INSIDE
AND TAKE THEM ALL THE WAY INTO
PRACTICE.
WE JUST HAD OUR KICKOFF MEETING
SEPTEMBER 1st AND TODAY'S MY
FIRST OFFICIAL REPORT TO
COUNCIL.
THE NEXT STEPS FOR US WILL BE TO
ESTABLISH REMEMBER MEETINGS FOR
THE SCOPE, BOUNDARIES AND
APPROACH AND DELIVERABLES AND A
MAJOR EFFORT HERE WILL BE TO
DEFINE THE SCOPE AND BOUNDARIES
BECAUSE AS YOU SAW, THIS IS
POTENTIALLY AN ENORMOUS PROGRESS
AND WE WANT MEANINGFUL
RECOMMENDATIONS IN THE TIME
RANGE OF A YEAR SO WE HAVE TO
DECIDE WHAT WE WANT TO FOCUS ON
AND HOW WE DO THIS.
WE WILL KEEP YOU POSTED THROUGH
REGULAR UPDATES AND IN THE
FUTURE OF THE COUNCIL MEETINGS
AND OF COURSE WE WILL FILL THE
NIDCR PARTICIPANTS IN OUR
WORKING GROUP AND MAKE SURE IS
THAT WHATEVER WE DO IS CLOSELY
ALIGNED WITH THE EXPECTATIONS OF
NIDCR P THAT CONCLUDES MY REPORT
AND I HOPE I LEFT A MINUTE OR
TWO FOR QUESTIONS.
>> Lynn M. King: THANK YOU.
ANY QUESTIONS?
ABOUT THE COUNCIL WORKING GROUP.
>> A BIG VIRTUAL HUG TO YOU.
THIS IS EXACTLY THE DIRECTION WE
HAD ENVISIONED AND I WONDERED IF
YOU GROUP WOULD CONSIDER THE
TRAINING OPPORTUNITIES.
WE'RE FINDING THAT DENTISTS OR
ORAL HEALTH RESEARCHERS ARE
NEEDED FOR THE DATA SCIENCE
FIELD SO THIS NEED FOR TRAINING
AND THE WOULD YOU DO RESOURCE
AND WHERE GAPS LIE, RIGHT?
>> YES, SO TO YOUR FIRST POINT,
YES, TRAINING OPPORTUNITIES THAT
TALK BRIEFLY ABOUT HOW THIS GOES
HAND AND HAND WITH BUILDING A
FUTURE WORKFORCE THAT COVERS
THIS AREA OF EXPERTISE AND
SPECIFICALLY, MAKES IT INTER
ELECT WITH THE NEEDS SO THAT
WOULD BE AN IMPORTANT ASPECT OF
IT.
IN TERMS OF LEVERAGING EXISTING
SYSTEMS, I THINK FIRST IMPORTANT
TASK WILL BE THE FACT FINDING
STAGE OF THIS WORKING GROUP TO
REALLY GET A SENSE OF.
>> ONE QUICK QUESTION.
THANK YOU FOR A TERRIFIC
PRESENTATION AND PUTTING ALL
THIS INFORMATION AND THE WORKING
GROUP TOGETHER.
>> THANK YOU FOR THAT
SUGGESTION.
>> WE DO HAVE THAT.
I'VE ALSO BECOME AWARE OF THESE
DENTAL INFORM ATTICS PROGRAMS ON
GOING SO IT'S TRAINING OUR NEXT
GENERATION OF PEOPLE WHO ARE
LIKELY CARRYING OUT THESE DATA
SCIENCES SO I'M JUST WONDERING
ABOUT INCLUSION OF THAT AS A
IMPORTANT STAKEHOLDER AS WE MOVE
FORWARD WITH THIS EFFORT, AXEL.
>> SO I THINK THIS WILL GO HAND
AND HAND.
AS WE MAKE RECOMMENDATIONS
VEMMING THE FUTURE WORKFORCE,
THIS SHOULD BE AN INTEGRAL PART
OF IT BECAUSE BY MAKING
RECOMMENDATIONS OF HOW THIS MAY
BE BUILT AND THIS CAN AT THE
SAME TIME, TAKE INTO
CONSIDERATION IN PARTICULAR
RECOMMENDATIONS THAT WE MAY GET
EVEN FROM THE OTHER WORKING
GROUP THAT FOCUSES MORE
SPECIFICALLY ON THESE ASPECTS.
>> YEAH.
>> IF THAT MAKES SENSE.
>> YEAH.
>> OK.
AT THIS POINT, WE HAVE A BREAK
SCHEDULED UNTIL 12:35 AND THAT
IS SHORTED BY THREE MINUTES IS
THAT OK BY EVERYONE TO RECONVENE
BY 12:35?
>> THANK YOU, VERY MUCH.
IT'S SETTING US UP FOR THE
FUTURE.
>> THANK YOU.
AND WE'LL SEE EVERYONE BACK.
>> MAY I INTERJECT.
THERE'S A TRADITION WAY TO DO
WORKING GROUPS BUT IF THERE'S A
WEBINAR IN THE MIDDLE OF THE
YEAR WHILE AXEL IS GATHERED HIS
DUE DILIGENCE TO JUST MAKE SURE
THE CONNECTIONS TO ADA AND THE
OTHER ORGANIZATIONS ARE MAINTAIN
AND TO OUR CONSTITUENTS IN
GENERAL AND IT COULD BE, I GUESS
THERE'S FLEXIBILITY TO DO THAT
STUFF, RIGHT.
COMMUNICATION.
>> ABSOLUTELY.
INVOLVING THE PUBLIC IN THE
CONVERSATION IS A KEY COMPONENT
OF THE WORKING GROUP.
>> WITH THAT COMES A WEBSITE
WITH PEOPLE COMING HERE AND
GIVING SEMINARS AND WORKSHOPS
AND THINGS SO THAT WE CAN BUILD
THE INTEREST.
>> YES.
WE SHOULD HAVE A SITE FOR A
WORKING GROUP POSTED ON YO OUR
PUBLIC FACING PART OF YOU ARE
INTERNET WEBSITE AND WE NEED TO
DEVELOP AND WE CAN POST ALL THAT
ADDITIONAL INFORMATION AND
MATERIALS THAT WOULD BE OF OF
INTEREST.
>> OUR NEXT
SPEAKER WILL BE Dr. DANA
GRAVES AND HE WILL PROVIDE AN
ORAL HEALTH RESEARCH WORKING
GROUP WHICH IS THE SECOND
WORKING GROUP THAT HAS BEEN
STOOD UP BY NIDCR.
IF WE CAN Dr. Dr. GRAVES, IF
YOU ARE GOING TO PRESENT YOUR
SLIDES.
>> JUST GIVE ME ONE SECOND.
CAN YOU SEE MY SCREEN?
>> Lynn M. King: YES, IT LOOKS
GREAT.
>> THANK YOU.
SO IT'S A REAL PLEASURE TO HAVE
THIS OPPORTUNITY TO SHARE THIS
IMPORTANT WORKING GROUP AND WHEN
RENA FIRST TOLD ME SHE'S GOING
TO GIVE ME A CHARGE, I THOUGHT,
WELL I DON'T HAVE AN ELECTRIC
CAR WITH A BATTERY PROBLEM BUT
IT TURNED OUT WHAT SHE WAS
REFERRING TO AS TASK OF
DEVELOPING AND RECOMMENDING AN
EVIDENCE BASED APPROACH TO
RETAIN WORKERS.
THIS IS IMPORTANT IN DENTAL,
CORRAL AND CRANIOFACIAL RESEARCH
FOR BECAUSE OF DWINDLING
NUMBERS.
WE HAVE FORMED AN WORKING GROUP
WITH HELP FROM LYNN KING AND
ANISA BROWN WHOA ARE MEMBERS AND
THIS IS IS A VERY ENERGETIC,
DIVERSE AND CHATTY GROUP AND WHO
ENJOY TALKING ABOUT TRAINING AND
ARE PASSIONATE ABOUT IT.
AS BACKGROUND, THERE'S A
SIGNIFICANT ISSUE WITH THE
WORKFORCE WHICH HAS DECLINED
OVER TIME IN DECADES.
THE DIVERSITY OF THIS WORKFORCE
IS LOW AND AN ISSUE THAT IS
IMPORTANT AND COMES UP
FREQUENTLY IS THE CAREER
PROGRESSION OF WOMEN DECLINING
COMPARED TO MEN.
FOR A DENTIST SCIENTIST, THERE
ARE ALSO SPECIFIC ISSUES THAT
INCLUDE THE HIGH LOAD OF
EDUCATIONAL DEBT, CHALLENGES AND
BALANCING CLINICAL AND RESEARCH
TRAINING, DIFFICULTY IN
BALANCING CAREER OBJECTIVES, AND
LACK OF SUPPORT AND INCENTIVES
WHICH IS OFTEN FELT BY THE
TRAINEES GOING INTO A CAREER
WITH LONG HORSE HOURS AND LOW PH
THAT IS NOT TRUE.
THERE'S A NEED TO INVIGORATE
TRAINING TO ENHANCE EMERGING
SCIENCES AND TECHNOLOGIES AND TO
ENHANCE INCREASE SCIENCE OF
WHICH AND ALSO TO INCREASE
TRANSLATIONAL RESEARCH WHICH IS
AN IMPORTANT OBJECTIVE FOR NIDCR
AND FOR NCCIH.
THE COMMITTEE HAS MET TWICE.
WE CAN FIND QUESTIONS THAT WERE
GOING TO BE IMPORTANT TO
ADDRESS.
AND SOME OF THESE QUESTIONS ARE,
WHAT DOES AN EXCELLENT PROGRAM
LOOK LIKE?
WHAT ARE THE OUTCOMES OF AN
OUTSTANDING PROGRAM?
WHAT TYPES OF TRAINING PROGRAMS
ARE EFFECTIVE?
AND WHAT CAN WE LEARN FROM
TRAINING PROGRAMS THAT ALREADY
EXIT AT NIDCR AND OTHER
INSTITUTES AND AGENCIES.
ADDITIONAL QUESTIONS ARE, WHAT
METHODS ARE USED FOR PROGRAMS
AND IT WOULD INCLUDE
INTERACTIONS WITH PHARMA WHICH
IS IMPORTANT AS WELL AS A
PARTNERSHIP WITH OTHER
STAKEHOLDERS.
THE OTHER ISSUE THAT THIS
WORKING GROUP IS GOING TO TACKLE
IS THE ISSUE OF DIVERSITY AND AN
IMPORTANT COMPONENT OF ENHANCING
DIVERSITY IS WHEN SHOULD THE
LEVEL OF ENGAGEMENT BEGIN.
SO THAT'S AN IMPORTANT QUESTION
THAT WAS BROUGHT UP.
SO WE HAVE OUTLINED FAIRLY
AGGRESSIVE AGENDA.
THE INITIAL MEETINGS FROM NOW
UNTIL DECEMBER WILL BE BASED ON
ACQUIRING INFORMATION, MEETING
WITH DIFFERENT STAKEHOLDER
GROUPS AND GETTING INFORMATION
FROM NIDCR AND OTHER TRAINING
PROGRAMS AT NIH.
THAT WILL BE FOLLOWED FROM
JANUARY TO MARCH WITH ADDRESSING
ACTION ITEMS AND THIS IS AN
EVALUATION PERIOD SO WE'LL TAKE
THE INFORMATION THAT WE RECEIVED
AND EVALUATE IT AND THEN FROM
APRIL TO JULY, WE WILL WORK ON
DEVELOPING RECOMMENDATIONS TO
THE COUNCIL.
SO THE INFORMATION SESSION HAVE
BEEN DEVELOPED AND OUTLINED.
THEY WILL INCLUDE A CURRENT
INFORMATION ON NIDCR RESEARCH
TRAINING PROGRAMS AND WE'VE
ALREADY HAD THIS INFORMATION
SESSION AND AN KNE ANISA BROWN N
EXCELLENT JOB.
WET ASSESS RESEARCH TRAINING
SESSIONS AND WE WILL LISTEN AND
THEY WILL BE WITH CURRENT AND
PREVIOUS TRAINEES AS WELL AS KEY
STAKEHOLDERS AND SOME OF THEE
SKI STAKE SHOULDERS GROUPS
INCLUDES PROGRAM DIRECTORS,
UNIVERSITY TRAINING PROGRAMS,
THEY WILL INCLUDE CHAIRS AND
DEANS THAT REPRESENT KEY
DECISION MAKERS AND HIRING
TRAINEES AND ALSO INDIVIDUALS IN
INDUSTRY CONSIDERING THEIR
TRAINEES CAN HAVE PRODUCTIVE
CAREERS, RESEARCH CAREERS IN
PHARMA.
THAT'S RELATED TO ORAL BIOLOGY.
WE'LL ALSO HAVE INFORMATION
SESSIONS FROM LEADERS OF
PROGRAMS, THESE ARE TRAINING
PROGRAMS AND OTHER INSTITUTES AT
NIH.
WE HAVE WRITTEN A REQUEST FOR
INFORMATION WHICH HAS BEEN
VETTED BY NIDCR NOW AND FOR
PUBLIC COMMENT ON TRAINING
PROGRAMS AND WE'VE ASKED THE
PUBLIC TO COMMENT ON THE
QUESTIONS WHICH I HAVE OUTLINED
HERE.
AND THEN WE WILL HAVE ADDITIONAL
STAKEHOLDER MEETINGS WITH
LISTENING SESSIONS AT THE
CONFERENCE IN MARCH AT AADOCR.
WE WILL THEN EVALUATE THE
INFORMATION THAT WE HAVE
RECEIVED AND OUR ACTION ITEMS
WILL BE ASSESSMENT OF FEEDBACK
FROM THE STAKEHOLDER GROUPS FROM
THE LISTENING SESSIONS AND AN
ASSESSMENT FROM THE ARFI WHICH
HAS BEEN DISSEMINATED TO THE
PUBLIC.
WE WILL EVALUATE CURRENT
INSTITUTIONAL PROGRAMS WITHIN
EMPHASIS ON SUCCESSES AND GAPS
AND WE WILL EVALUATE CURRENT
INDIVIDUAL PROGRAMS EVALUATING
SUCCESSES AND GAPS.
ONE OF THE IMPORTANT AREAS OF
INVESTIGATION AND ACTION WILL BE
WHAT TYPES OF PROGRAMS ARE MOST
SUCCESSFUL?
WHAT GIVES OUTCOMES THAT ARE
MOST PRODUCTIVE AND ONE
COMPARISON IS INSTITUTION
PROGRAMS VERSUS INDIVIDUAL
PROGRAMS WHERE THE APPLICANT
WRITES AN AWARD FOR FUNDING AND
WE WILL MAKE RECOMMENDATIONS TO
THE COUNCIL ON BOTH INDIVIDUAL
AND INSTITUTION BASED PROGRAMS
AND EMBEDDED IN ALL OF THESE
RECOMMENDATIONS WILL BE THE
CONCEPT OF INCREASING DIVERSITY
AND INCLUSION.
THIS WOULD INCLUDE ELEMENTARY
SCHOOL GOING FORWARD TO
ESPECIALLY UNDER REPRESENTED
COMMUNITIES WHO MAKE THE
STUDENTS AWARE THAT THERE ARE
OPPORTUNITIES FOR RESEARCH IN
ORAL HEALTH OR CRANIAL RESEARCH.
WE WILL DEVELOP NEW PROGRAMS TO
INCLUDE AND SUPPORT DOCTORAL OR
CANDIDATES FOR DOC RESEARCH AS
WELL AS DEVELOP NEW PROGRAMS TO
RECRUIT, SUPPORT AND RETAIN
POSTDOCS, NOT TRADITIONAL PH.D
OR FACULTY THAT ARE IN DOM
RESEARCH ALREADY.
THE NONTRADITIONAL RESEARCH IN
TERMS OF DOC REPRESENTS BIO
BIO-INFORMATICS, ENGINEERING AND
OTHER FIELDS WHERE THERE'S A
NATURAL RELATIONSHIP TO DENTAL
AND ORAL CRANE CRASH FACIAL
RESEARCH.
AS WELL AS CLINICAL RESEARCH.
WE WILL DEVELOP METRICS TO
ACCESSORY SEARCH TRAINING
PROGRAMS AND TO ACCESSORY
TENSION PROGRAMS.
WE WILL ADDRESS ISSUES OF
TRAINEE RESEARCH AS WELL AS
CAPACITY AND THIS WILL PROVIDE
DATABASES AND INFORMATION FOR
THOSE WHO ARE INTERESTED AS WELL
AS PROVIDE A PATH FOR THEM TO
FOLLOW.
SO THEY HAVE STRUCTURE OF WHAT
IS AVAILABLE.
WE'LL ALSO PROMOTE RESEARCH OR
DEVELOP PROGRAMS THAT PROMOTE
RESEARCH IN TRAINING AREAS THAT
WILL ALIGN WITH THE STRATEGIC
PLAN AND THAT'S BEEN OUTLINED
ALREADY AND INCLUDES THE PAIN
RESEARCH OF BIG DATA AND
TRANSLATIONAL RESEARCH AND SO ON
AND WILL ALSO DEVELOP TRAINING
PROGRAMS SO THAT TRAINEES ARE
EXPOSED TO EMERGING AND CUTTING
EDGE RESEARCH.
IT MIGHT GO BEYOND WHAT THEY
WOULD RECEIVE IN THEIR DEGREE
PROGRAMS.
SO WITH THAT I WOULD LIKE TO
SAY, THANK YOU AND TO REASSURE
EVERYONE THAT WE WILL BE WORKING
VERY DILIGENT LEON THIS TOPIC.
THANK YOU Dr. GRAVES, ARE
THERE ANY COMMENTS OR QUESTIONS.
NO ONE HAS ANY THOUGHTS?
COMMENTS ON THE WORKING GROUP.
>> I DO HAVE ONE IF I COULD.
I MEAN, LOOKING AT THE ENTIRE
HISTORY OF TRAINING WOULD BE
PROBABLY A LITTLE BIT TOO
AMBITIOUS BECAUSE IT WAS IN JIM
LIPTON'S TIME HOW THEY WERE
HANDLED BUT, HOWEVER I WAS MORE
CURIOUS AS TO HOW THE BALANCE
WOULD BE CREATED AND IN KIND OF
ALMOST TAKING FOR GRANTED WHAT
THE GLITCHES ARE WHICH ARE
OBVIOUS, RIGHT, HIGH TUITION,
LONG TRAINING PROGRAMS FOR
DDSBHDs AND PROJECTS THAT THEY
NOT ALWAYS CAN CREE LATE TO IN
TERMS OF THEIR CLINICAL SKILLS.
THERE'S ALL OF THESE THAT ARE
PRETTY OBVIOUS.
WOULD YOU BE BALANCING IT OUT
MORE WITH LOOKING AT OUTCOMES OF
RETURN OF INVESTMENTS SO WE CAN
REALLY LOOK TO THE FUTURE WITH A
REVISED SET OF GOALS?
I DON'T KNOW HOW WOULD YOU DO
THAT BECAUSE IF IT'S A VERY --
IT'S A LABOR INTENSE PROCESS.
>> YES, SO, I LAID OUT PRE
TEMPORAL TRANSITIONS THAT WE
WILL UNDERTAKE AND THE FIRST
WILL BE INFORMATION GATHERING
THE INFORMATION AND THEN THE
SECOND PHASE WILL BE EVALUATING
IT AND ONE OF THE KEY THINGS IS
TO EVALUATE WHAT ENABLES A
PERSON OR STUDENTS TO
SUCCESSFULLY TRANSITION TO A
RESEARCH CAREER FROM BEING A
STUDENT.
HOW DO YOU OPEN DOORS AND I
EXPECT WE'LL BE LOOKING AT HOW
DO YOU INCENTIVIZE MENTORS
BECAUSE THEY OPEN THE DOORS FOR
THE STUDENTS NOTHING FURTHER
PEOPLE INTEND TO BE DENTISTS NOT
RESEARCHERS BUT THESE STORIES
ARE OPEN SO TO YOU DO YOU MAKE
PEOPLE OR STUDENTS AWARE THAT
THEY HAVE THESE OPPORTUNITIES
AND THEY ARE WELL ESTABLISHED
AND OUR OWN RISK SO I THINK THAT
WHEN WE EVALUATE THAT WILL BE A
DIVAC OR.
>> ANYONE ELSE?
>> WELL, IF NOT --
>> I WOULD MAKE A COMMENT,
MAYBE.
>> AS I'M PREPARING THE
COMMITTEE WITH DANA, I THINK AS
WE MOVE THROUGH YOUR CAREER
SOMETIMES IT BECOMES OBVIOUS
THAT THERE'S NOTHING MORE
IMPORTANT THAN TRAINING THE NEXT
GENERATION SO I THINK WE'RE VERY
LUCKY TO HAVE THIS WORKING GROUP
AND I WANT TO THANK YOU FOR
ESTABLISHING IT AND DANA FOR
LEADING IT AND I THINK WE HAVE A
WONDERFUL GROUP AND I EXPECT
WE'LL HAVE SOME TERRIFIC
RECOMMENDATIONS THAT CAN REALLY
MOVE THE BAR AND I MY SO
SUBPOENA OF OBVIOUS BEEN
FRUSTRATED BY SEEING TALENTED
YOUNG SCIENTISTS IN OUR FIELD
WHO DON'T CONDITION SO THINGS
ARE A LITTLE WONKY BUT ANYWAY,
I'M HAPPY TO BE HERE AND THANK
YOU.
>> THANK YOU.
>> THANK YOU FOR THOSE COMMENTS.
>> THANK YOU SO MUCH FOR LEADING
THE WAY ON THIS AND IT SEEMS
LIKE IN THE RECORDING THE ARENA
PRESENTED WE ALREADY HAVE TWO
KIND OF MODEL PROGRAMS IN A
SENSE AND ONE IS THE FUNDED
ACTIVITIES THAT THE AVCOR HAS
WHICH IS FINE THE FUTURE PROGRAM
TO GRAB FOLKS RIGHT AT THAT
CHALLENGING PERIOD AND EARLY
STAGE IN THEIR CAREER AND NOW WE
HAVE THE PRIME PROGRAM RFA OUT
THERE BUT THOSE ARE TWO GREAT
EXAMPLES POTENTIALLY THAT COULD
FIT RIGHT INTO WHAT YOUR
WORKGROUP IS FOCUSING ON.
>> I ALSO THINK THAT THEY
REPRESENT PARTNERSHIPS WHICH IS
PART OF THIS AND THE DENTAL
SCHOOLS NEED TO BE PART OF THIS
THAT'S WHY WE'RE HAVING
INFORMATION SESSIONS WITH DEANS
EX CHAIRS TO GET WHAT DO THEY
WANT IN?
WHAT TYPE OF DIALOGUE NEEDS TO
TAKE PLACE SO IS THAT THEY CAN
NURTURE A STUDENT.
>> YEAH, OBVIOUSLY, YOU KNOW,
THE I REMEMBER LARRY TABAK
SHARING HA HE HAD THAT MEETING
WITH DEAN'S COUNCIL AND HE SAID
THE JOB OPPORTUNITIES LION
SPECIALTY DEPARTMENTS AND THAT
IS TRUE.
EVEN UNTIL TODAY.
BUT YOU CAN HAVE A DDS AND A
PH.D AND STILL BE IN A SPECIALTY
DEPARTMENT YOU DON'T HAVE TO
HAVE A SPECIALTY BECAUSE WHAT
THAT DOES IS MEET THE NEEDS OF
THE IMMEDIATE NEEDS OF THE
DEPARTMENT AT HAND AND YOU LAND
OF DILUTING OUT YOUR TIME IN THE
LAB.
I HOPE YOU WILL GIVE IT A REAL
BROAD SWEEP AND DEEP AS WELL.
DIVE DEEP AS WELL.
THANK YOU.
AND CREATIVE.
YES.
>> THANK YOU.
>> LYNN, CAN I JUST KEEP
INTERRUPTING BUT IF YOU ALL HAVE
IDEAS HOW WE CAN FULLY LEVERAGE
AND CAPITALIZE ON OUR TRAINING
CELEBRATIONS, OUR CELEBRATIONS
OF OUR TRAINEES FOR OUR 75t
75th IN OCTOBER OF NEXT YEAR,
PLEASE DO FEEL IT IN AND IT WILL
BE BASED ON WHAT YOU GATHER AS
DATA.
WE COULD HAVE BREAKOUT SESSIONS,
MENTORING, LUNCHES AND THINGS
LIKE THAT.
>> YEAH, WE CAN TALK ABOUT THAT
EVENT WITH A WORKING GROUP AND
SEE WHAT THEY MIGHT HAVE.
WHAT THEY WOULD LIKE TO ENGAGE
IN TOO SO THAT'S A GREAT IDEA.
>> THANK YOU.
>> Lynn M. King: SO MOVING ON WE
HAVE Dr. BRUCE DONOFF.
YOU HEARD HIS INTRODUCTION
EARLIER ON REDESIGNING AND
IMPROVING HEALTHCARE THROUGH
INTEGRATION OF ORAL AND MEDICAL
RESEARCH AND PRACTICE.
>> THANK YOU, VERY MUCH.
IF SOMEONE CAN PUT UP MY SLIDES.
I AM VERY HONORED AND PLEASED TO
HAVE BEEN ASKED TO ADDRESS THIS.
I'M SITTING HERE, I'M TRYING TO
THINK DOES OMB2 STILL EXIST.
I USED TO SERVE ON OMB2.
[LAUGHTER]
>> THAT DATES YOU.
>> SO, I'D LIKE TO START BY
QUOTING THE PAPER THAT RENA AND
SUSAN, FRANCIS COLLINS AND THEY
HAD IN THE NEW ENGLAND JOURNAL
BACK IN MARCH AND IT'S CRITICAL
THAT WE BUILD ON THIS KNOWLEDGE
AND THE SCIENTIFIC PROGRESS WE
MADE TO ENSURE THAT ORAL HEALTH
IS FULLY INTEGRATED INTO THIS
NEW ERA OF DISCOVERY AND TO
HARNESS POLICY CHANGES AND
TECHNOLOGICAL DISADVANTAGES TO
DISRUPT SYSTEMIC INEQUITIES.
ONLY THEN WILL WE TRULY IMPROVE
THE HEALTH OF PEOPLE, FAMILIES
AND COMMUNITIES AND I BELIEVE
THAT.
SO I WILL TALK ABOUT REDESIGNING
AND IMPROVING HEALTHCARE BY
INTEGRATED ORAL AND MEDICAL
RESEARCH AND PRACTICE SOMETHING
I AM QUITE PASSIONATE ABOUT.
INNOVATION, HAS ITS ENEMIES AND
VERY OFTEN ORGANIZED HEALTHCARE
GROUPS ARE THE ENEMIES, WHETHER
IT'S THE AMERICAN MEDICAL
ASSOCIATION OR THE AMERICAN
DENTAL ASSOCIATION.
SO THE REAL QUESTION, IS CAN HE
WE CREATE DENTAL MEDICAL
CHAMPIONS FOR CHANGE.
IN FACT, I THINK YOU INTRODUCED
ONE AT YOUR OWN INSTITUTE,
SOMEONE I KNOW, AND THAT IS
JANICE LEE.
SO WHAT I WOULD LIKE TO DO IS
REVIEW THE HISTORY.
MORE RECENT DISCUSSIONS ABOUT
THIS TOPIC AND THE POS ABILITIES
FOR CHANGE NOW.
SO, I THINK ONE OF THE THINGS
THAT WE HAVE TO CONSIDER IN
DOING THIS IS CHANGING THE SCOPE
OF DEPARTMENTAL PRACTICE.
I THINK THAT THERE'S A PLACE FOR
OLYMPIC ORAL HEALTH AND PRIMARY
CARE AND I THINK WE NEED TO
THINK OF CHANGE VERSUS
CONTINUITY AND WE NEED TO THINK
OF INNOVATION VERSUS INKUM BEN
SEE AND TWO OF MY FAVORITE AREAS
DISRUPTIVE INNOVATION, WHICH WAS
THE BRAINCHILD OF CLAY
CHRISTIANSON.
AND IN CERTAIN OF THOSE CHANGES
I'M REMINDED THAT ABOUT TWO AND
A HALF YEARS AGO, THE AMERICAN
DENTAL ASSOCIATION HAD AN
ANNOUNCEMENT THAT SAID THAT ALL
DENTISTS SHOULD ADVOCATE FOR
PATIENTS GETTING HPV
VACCINATIONS.
AND MY RESPONSE TO THAT IS, WHY
DON'T DENTISTS GIVE HPV
VACCINATIONS?
WE GIVE BIG MAN DIBULA BLOCKS.
LET'S RETURN TO A HISTORY OF
THIS TOPIC IN THE UNITED STATES.
THE BALTIMORE COLLEGE OF
DENTISTRY WAS THE FIRST DENTAL
SCHOOL IN AMERICA.
WHAT IF IT HAD BECOME PART OF
THE UNIVERSITY OF MARYLAND
MEDICAL SCHOOL, NO ONE IS QUITE
SURE IF THE DENTISTS ORIGINATORS
DIDN'T WANT TO JOIN OR THE
MEDICAL SCHOOL DIDN'T WANT THEM.
BUT JUST THINK OF WHAT WOULD BE
DIFFERENT IF THAT DENTAL SCHOOL
WAS PART OF THE MEDICAL SCHOOL.
NEXT, WE HAD MY OWN INSTITUTION,
THE HARVARD DENTAL SCHOOL WHICH
CAUSED ALL SORTS OF PROBLEMS IN
1867 BY FORMING A DENTAL SCHOOL
AND GIVING A DMD DEGREE.
HOW SILLY.
>> SO THERE ARE ATTEMPTS THROUGH
THE YEARS AND JUST A QUICK
REVIEW, THE GUYS REPORT SAID
THAT DENTISTRY SHOULD ALWAYS BE
ALIGN FROM SEPARATE FROM
MEDICINE.
LITTLE GUYS WAS . CHEMIST AT
COLOMBIA.
ALFRED OWRE WAS THE DEAN AT
COLOMBIA.
HE WAS A DUEL-DEGREE DENTIST AND
HE WAS PASSIONATE ABOUT MEDICAL,
DENTAL INTEGRATION AND GUESS
WHAT HAPPENED, THE FIRST
DIRECTING DENTAL SOCIETY OF NEW
YORK CITY RAN HIM OUT OF TOWN.
IN THE 1930s AND LATE 1940s
DEAN FROM YALE MEDICAL SCHOOL
WAS VERY PROGRESSIVE AND
DEVELOPED AN MD PROGRAM FOR
DENTISTS AND HE FELT
SPECIFICALLY IT WOULD IMPROVE
THEIR KNOWLEDGE AND ABILITY TO
DO RESEARCH.
THAT EXPERIMENTS ARE IMPORTANT
AND PILOT PROGRAMS ARE
IMPORTANT.
SO JUST THREE PEOPLE CAME OUT OF
THAT PROGRAM, LESTER BURKETT
FROM THE UNIVERSITY OF
PENNSYLVANIA AND KRESHOVER WHO
BECAME A DIRECTOR OF THE NIDCR
AND DAVID WEISBERGER WHO WAS A
LEADER AND MY TEACHER AT
HARVARD.
AND THEN THERE WAS THE HARVARD
EXPERIMENT OF 1940 DEEM TO
FAILURE WHERE EVERYBODY COMING
INTO THE DENTAL SCHOOL GOT BOTH
AN M.D. AND A DMD AND THE VERY
SUCCESSFUL MGH ORAL AND FACIAL
SURGERY PROGRAM WHICH BEGAN IN
1961 AND WHICH NOW NUMBERS ABOUT
50 PLUS PROGRAMS MANY OF THE
IMPORTANT THING ABOUT THE LAST
PROGRAM IS, THAT PROGRAM CAME
ABOUT BECAUSE OF THE DESIRES OF
APPLICANTS.
IT WASN'T NECESSARY, THE DESIRES
OF ACADEMICS OR PEOPLE IN POWER.
THE NEXT, PLEASE.
THERE HAVE BEEN A NUMBER OF
REPORTS OF IMPORTANCE.
THE GIES REPORT WHICH I
MENTIONED, DENTAL APPLICATION
FROM THE CROSS ROADS FROM THE
PREVIOUS INSTITUTE OF MEDICINE
IN 1995 WAS A WONDERFUL REPORT
IN FACT, RECOMMENDING CERTAIN
CHANGES AND CERTAIN STABILITY IN
EDUCATION.
IT HAD ON ITS COLORS LAVENDER
AND GREEN, THE ACADEMIC COLORS
OF MEDICINE AND DENTISTRY BUT
STUDIES SHOWED THAT IT WAS READ
BY LESS THAN 15% OF PEOPLE IN
THE HEALTH PROFESSIONS.
AND THEN THERE WAS THE 21 CENTS
REGUYS REPORT LED BY ALAN FORMER
SUPPORTED BY THE ADA AND OTHER
GROUPS.
AND THAT WAS A VERY SUBSTANTIAL
REPORT BUT REALLY LED TO VERY
LITTLE CHANGES.
THERE WERE LOTS OF SUGGESTIONS
AND SOME REALLY KEY PLAYERS
INCLUDING LORI MCCAULEY AND
MYSELF AND OTHER PEOPLE WHO WERE
VERY WROTE PAPERS AND THE PEOPLE
AND THE AREA YOU ARE TRYING TO
CHANGE HAVE TO WANT TO CHANGE
AND THEN THERE WAS THE VERY
SUCCESSFUL ORAL HEALTH IN
AMERICAN REPORT THAT STARTED OUT
AS A SECOND SURGEON GENERAL'S
REPORT AND WAS EVENTUALLY ISSUED
THROUGH THE NIDCR.
ON THE RIGHT, IS A PAPER BY
HENDRICKSON AND PETER COHEN,
ORAL HEALTHCARE IN THE 21s
21st CENTURY.
IMPLICATIONS FOR DENTAL AND
MEDICAL EDUCATION.
THIS CAME OUT IN DECEMBER OF
2021 AND ACADEMIC MEDICINE AND
IN FACT, IT WAS THE LAST PAPER
ON THIS TOPIC THAT APPEARED IN A
MEDICAL EDUCATION JOURNAL.
THAT IS TELLING.
NEXT, PLEASE.
NOW, THERE ARE STRATEGIC
PRIORITIES AT THE NIDCR AND I'LL
HIGHLIGHT THIS PAPER WHICH
APPEARED IN FRONTIERS WHICH IS
AUTHORED BY Dr. MERIDIAN,
JANICE LEE, MARTHA SUMMERMAN AND
IT CALLED FOR THESE PRIORITIES
FOR THE NIDCR TO INTEGRATE ORAL
AND GENERAL HEALTH, DEVELOP
PRECISE AND INDIVIDUALIZED
TREATMENTS AND TRANSLATE AND
IMPLEMENT THAT NEW KNOWLEDGE AND
TO CREATE DIVERSE RESEARCH
PIPELINE AND TO PARTNER AND
COLLABORATE TO MAKE THAT PART OF
ONCE' BEING SO TO SPEAK.
THE OTHER THING I MUST SAY
HAVING SEEN THIS PRIMATE COME
OUT, WHEN I WOULD SEE MARTHA
SUMMERMAN IN A MEETING, SHE KNEW
HOW I FELT ABOUT THE PBRNs AND
SO SHE ALWAYS WOULD TRY AND
CHANGE THE SUBJECT.
SO REALLY, I'M REALLY HAPPY THAT
YOU ARE DOING -- NEXT SLIDE.
THANK YOU.
SO THE MAIN ISSUES FOR CHANGE
NOW, WHICH YOU HAVE HEARD ABOUT
BEFORE, AND WHICH I'LL TRY AND
MAKE THE POINT THAT A DUEL
DEGREE CAN HELP ACHIEVE, ACCESS
AND DISPARITIES OF CARE
PARTICULARLY THE UNDERSERVED
GROUPS AND THE ENDANGERED
SCIENTIST TO ADVANCE SIGNS AND
MEDICAL TREATMENT OF SURGICAL
DISEASE, TO TEACH ORAL HEALTH TO
MEDICAL STUDENTS AND RESIDENTS
BECAUSE I DO NOT THINK THAT
INTER PROFESSIONAL EDUCATION IS
DOING IT.
CHANGE IS CARD.
AND JUST I'M A STORY TELLER.
TALKED ABOUT HOW QUICKLY ETHER
ANESTHESIAIA, THE ANNIVERSARY OF
WHICH IS COMING UP IN OCTOBER,
HOW QUICKLY IT WAS ADOPTED BY
THE MEDICAL COMMUNITY.
AND IN THOSE DAYS, 1846, ABOUT
THE ONLY OPERATION THAT DID
SUCCESSFULLY WAS AM YOUTATIONS
BUT THAT WAS REALLY LATCHED ON
TO VERSUS LISTERS, IDEAS AN A
SEPSIS WHICH MEANT WORK FOR THE
DOCTORS AND WAS VERY SLOW AT
BEING ADOPTED.
I DRAW THE COMPARISON BETWEEN
TAKING CARE OF HIV AND IMPLANTS.
IMPLANTS WERE ADAPTED BY
WILDFIRE AND THE DENTAL
PROFESSION WAS SLOW TO DEAL WITH
HIV-INFECTED PATIENTS.
LINSK TALKED ABOUT ADAPTIVE
VERSUS TECHNICAL CHANGEMENT
WE'RE GOOD AT TECHNICAL CHANGE
BUT ADAPTIVE CHANGE IS
TRANSFORMATIVE AND THAT'S WHAT
YOU ARE TRYING TO DO AND THAT'S
WHAT I'M TRYING TO TALK ABOUT.
IT ALWAYS INVOLVES A LOSS FOR
SOMEONE AND THAT IS HARD FOR
PROFESSIONALS WHO HAVE BEEN AT
THEIR WORK FOR SOME TIME TAKING
GREAT CARE OF PATIENTS TO ADMIT.
SO TWO QUICK STORIES FROM 1973.
SECRETARY AT WAS A GREAT RACE
HORSE.
HE WON THE KENTUCKY DERBY AND HE
WON THE PREAKNESS AND HE STOPPED
TRAINING.
HE WOULDN'T RUN WELL AND THE
BELMONT WAS COMING UP AND HIS
TRAINER CALLED THE VET.
THE VET CAME TO SEE THE HORSE
AND FOUND A DENTAL ABSCESS.
THAT VET WASN'T RESTRICTED BY
ANY PRACTICE ACTS IN DOING WHAT
HE NEEDED TO DO TO TAKE CARE OF
THAT INFECTION.
HE DRAINED IT AND SECRETARIATE
BEGAN TO TRAIN AND EAT AND WON
THE BELMONT BY 23 FUR LONGS.
WHEN I WAS A MEDICAL STUDENT, I
WAS ASKED TO SEE A PATIENT AT A
PARTICULAR HARVARD HOSPITAL, WHO
HAD 105° FEVER, COMATOSE AND
THEY WERE SURE HE HAD MENINGITIS
BUT THEY COULDN'T FIND THE
SOURCE OF THE INFECTION.
WELL, LOW AND BEHOLD, LOOKING IN
THE MOUTH, DISCLOSED AN INFECTED
WISDOM TOOTH.
PHYSICIANS DON'T NECESSARILY
LOOK IN THE MOUTH AND THAT IS
WHAT MY CALL IS.
PUT THE MOUTH BACK IN THE BODY.
TALKING ABOUT SOME OF THE THINGS
IN DATABASES I REMEMBER WHEN THE
JUPITER TRIAL OF PROTEIN IN STAT
ENTERS CAME OUT, I MET WITH PAUL
RIDKA BECAUSE I WAS VERY
SURPRISED THAT THEY HAD IT
17,803 PATIENTS BUT NOT ONE
DENTIST WAS INVOLVED IN THE
STUDY.
THERE WAS NO EXAMINATION FOR
PERRY TONIGPERPERTONIGHTAL DISED
TO SEE ME -- EVERY LECTURE
STARTED WITH, WE DON'T SEE WHY
YOU SHOULD KNOW THIS.
IT'S SAD.
WELL WE SHOULD KNOW THIS.
IT'S TIME FOR A NEW GIES REPORT
THAT I WROTE IN 2009.
THE IMPORTANT POINT THAT
EXPERIMENTS CAN WORK.
THIS TALKS ABOUT A LOT OF
DIFFERENT KINDS OF PROGRAMS, ONE
OF THE MOST SUCCESSFUL, ARE
PREVIOUS SPEAKER IS A PRODUCT
OF.
THE Dr. MEDICAL SCIENCE
PROGRAM WHICH WAS INITIATED BY
PAUL GOLDAVER.
153 PEOPLE WENT INTO THAT
PROGRAM AND 93 STAYED IN FULL
TIME ACADEMICS AND RESEARCH.
AMAZING WORK.
I MEAN, THOSE ARE THE KINDS OF
THINGS THAT REALLY WORK AND IT'S
INTERESTING THAT OTHER PROGRAMS
IN THAT CATEGORY ORAL SCIENCE
PH.D THAT HAD A NIDCR TRAINING
GRANT AND WITH SEVERAL OTHER
WELL-KNOWN PEOPLE WENT THROUGH
THAT PROGRAM SO THE KINDS OF
THINGS THAT YOUR CONSIDERING
DOING, AS EXPERIMENTS IN PILOT
PROGRAMS ARE IMPORTANT.
AND THEY'RE RIGHT INTEGRATING
ORAL HEALTH IN GENERAL.
THE IMPORTANT THING AS RENA HAS
POINTED OUT, THAT A DENTAL
INSTITUTE CAME ABOUT BECAUSE OF
THE FAILURE OF PEOPLE TO BE
DRAFTED FOR WORLD WAR II AND WE
NEEDED SEVERAL MAN DAB YOU LAR
TEETH TO PULL A PIN ON A HAND
GRENADE IF YOU CAN'T DO THAT YOU
COULDN'T SERVE IN THE SERVICE.
IT'S COME A LONG WAY SINCE THEN.
THEY NEED TO STAY INVOLVED.
NEXT SLIDE, PLEASE.
THANK YOU.
SO HERE IS THE INTRODUCTION TO
ADVANCING DENTAL EDUCATION.
THIS WAS THE 21st CENTURY GIES
REPORT THAT LOOKED AT THE
PROFESSION IN GREAT DEPTH AND IN
DEED, THE PROBLEM IS THAT PEOPLE
DON'T WANT TO MAKE CHANGES.
WE INTRODUCED INTO PROFESSIONAL
EDUCATION.
WE TALK ABOUT A LOT OF THINGS
AND IN DEED, MOST OF DENTAL
EDUCATION IS ABOUT PROCEDURES
AND ON THE RIGHT WAS ATTEMPTED
WE MADE AT HARVARD TO INTRODUCE
AN INTEGRATED PRIMARY DENTAL
CARE SERVICES CLINIC WHICH HAS
WORKED OUT WITH NURSE
PRACTITIONERS VERY WELL AND HAS
BEEN A MODEL FOR OTHER PEOPLE TO
COPY.
NEXT, PLEASE.
MONTE MCNEIL AT UCONN MADE A
VERY GOOD CASE FOR INTEGRATED
ORAL AND PRIMARY MEDICAL
HEALTHCARE DELIVERY AND A FEW
YEARS AGO I WROTE WITH THE DEAN
OF MEDICAL SCHOOL THAT IT'S TIME
FOR THE INTEGRATION OF DENTAL
AND MEDICAL EDUCATION AND WE'RE
STILL AT THE POINT OF
NEGOTIATING THOSE CHANGES
BECAUSE YOU KNOW WHAT GOT IN THE
WAY OF PANDEMIC.
THE NEXT PLEASE.
HERE IS THE PAPER THAT ORAL
HEALTH FOR ALL REALIZING THE
PROMISE OF SCIENCE AND IT REALLY
IS WELL WRITTEN BUT ON THE RIGHT
IS A PIECE FROM THE SCIENCE
TIMES TUESDAY IN THE "NEW YORK
TIMES" BEHIND HEALTH ROBBING
AILMENTS, INFLAMMATION AND GUESS
WHAT IS NOT MENTIONED AT ALL --
PERPERIODONTAL DISEASE.
WE HAVE A LOT OF WORK TO DO.
WE CAN'T JUST TALK TO OURSELVES.
THERE HAVE BEEN SEVERAL
RECOMMENDATIONS FOR REVIEW OF
INSTITUTIONS THAT HAVE DONE
MEDICAL INTEGRATION, KAISER
PERMANENTE, HEALTH PARTNERS IN
MINNESOTA.
GREATER 'EM PHYSICIAN SHOULD BE
PLACED ON FOUNDATIONAL AND
APPLIED MEDICAL EDUCATION WITHIN
THE DENTAL CURRICULUM.
DENTAL SCHOOLS AND OTHER DENTAL
EDUCATION INSTITUTIONS SHOULD
PURSUE AN INTEGRATED
MULTI-DISCIPLINARY APPROACH IN
THE OVER ALL CURRICULUM AND
DENTAL GRADUATES SHOULD BE MORE
KILLED AND USING HEALTH ANALYTIC
TOOLS AND IN THE INTERPRETATION
OF SUMMARY INFORMATION FROM THE
LARGE SETS OF HEALTHCARE DATA
AVAILABLE AND THEY'VE TALKED
ABOUT THAT.
DENTAL EDUCATION MUST MAKE A
BOLD MOVE TO ACQUIRE HEALTH
RECOMMENDATIONS WHICH IS
IMPORTANT AND CHANGING THE
CULTURAL AND THE PROFESSION IS
MUCH MORE IMPORTANT SO, I USED
TO, WHEN WE HAVE THESE THINGS
HERE, HOW DO WE OPT FOR CHANGE?
WE CAN CHANGE THE PRACTICE ACTS
IN THE FACE OF POLITICS, VERY
DIFFICULT.
WE CAN ADD IPE PRACTICE AND
NURSE PRACTITIONERS AND WE CAN
CHANGE DENTAL EDUCATION.
IT'S NOT AN EASY TASK.
BUT I LIKE THE IDEA OF A
DUEL-DEGREE AND RESIDENCY THAT
WOULD MAKE SOMEONE THE
EQUIVALENT OF ANYONE ELSE IN
HEALTHCARE SO THAT YOU COULD
REALLY DEVELOP CHAMPIONS FOR
PUTTING THE MOUTH BACK IN THE
BODY AND YOU DON'T NEED A
THOUSAND OF THESE PEOPLE.
YOU YOU DON'T NEED 15000 OF
THESE PEOPLE BUT MAYBE 50 TO 100
COULD CHANGE THE SCENE AND IN
FACT, ALTHOUGH THE ORIGINAL
PLANS WAS FOR DENTAL SCHOOL TO
MEDICAL SCHOOL IS PART OF THIS
KIND OF TRAINING, FOLLOWED BY
APPROPRIATE RESIDENCY, YOU WOULD
HAVE TWO OPPORTUNITIES NOW FOR
MEDICAL SCHOOLS STUDENTS TO COME
THOUGH DENTAL SCHOOLS WITH
ADVANCED STANDINGS AND IT'S AN
INTERESTING WAY TO DO IT AND
ALTHOUGH WORKING WITH TWO VERY
FINE MEDICAL SCHOOLS THAT DON'T
HAVE DENTAL SCHOOLS TO TRY AND
ACCOMPLISH IT AND IN FACT, THE
WHOLE IDEA OF WHAT YOU'VE DONE
HERE IN TRANSFORMING THE PBRN IS
VERY EXCITE TO ME.
I HAVEN'T HAD A WHOLE HOST OF
TIME TO LOOK AT THIS BY THINK
ALTHOUGH IT WAS MEANT TO MOVE
PVRNs AND RESEARCH OUT OF THE
PRIVATE OFFICE, EVEN UNDER THE
INFLUENCE OF DENTAL SERVICE
ORGANIZATIONS, DO YOU THIS IN
DENTAL SCHOOLS AND HOSPITALS SO
THAT STUDENTS WORKED WITH OTHER
MEMBERS OF THE HEALTH
PROFESSIONAL AND I THINK SINCE
THIS IS COME OUT AND ME READING
IT I THINK IT'S A REAL
POSSIBILITY.
SOMEONE JUST ASKED ABOUT GPRs
AND I SERVED FOR SEVEN YEARS
WITH ALAN FORMER COLA ON A
COMMITTEE TO MAKE GPRs MORE
IMPORTANT AND IN FACT, AND HE
USED TO SAY, WHEN I WANT TO GET
A PRESENT FOR SOMEONE, I WOULD
GO TO BEST BUY.
IF I WANTED TO GET SOMETHING TO
FIX SOMETHING AROUND MY HOUSE, I
WOULD GO TO HOME DEPOT BUT THEN
I COULD GO TO ONE STORE,
WAL-MART AND IF I NEEDED
GASOLINE, I WOULD GO TO AN ESSO
GAS STATION.
IF I NEEDED A SNACK I WENT TO A
711 BUT THEN I COULD GO TO AN
INTEGRATED GAS STATION SNACK
PLACE AND TO ACCOMPLISH THIS AND
HE WAS A GREAT FAN OF THE IDEA
OF INTEGRATED PRACTICE.
NEXT, PLEASE.
SO, THERE HAVE BEEN LOTS OF
MAJOR REPORTS.
WE HAVE ENOUGH REPORTS TO LAST
US A LIFETIME.
THE IOM REPORT, THE FIRST
SURGEON GENERAL'S REPORT AND
IDEAS, EFFORTS AND INTER
PROFESSIONAL ALLIANCE AND THE
21st CENTURY GEIS REPORT, THE
DENTIST SCIENTIST WORKFORCE
ISSUE AND THE 2020 SURGEON
GENERAL'S REPORT ON ORAL HEALTH,
WHICH WE ALL KNOW ABOUT, THE
NEXT, PLEASE.
THE NEXT.
I PUT HIM TO SLEEP.
[LAUGHTER]
>> DON'T LET A CRISIS GO TO
WASTE AND WE CERTAINLY HAD A
CRISIS.
THE PANDEMIC, MANY SMARTER
PEOPLE THAN I HAVE WRITTEN ABOUT
WHAT IT'S DONE TO HEALTHCARE AND
ECONOMICS PUBLIC-HEALTH BUT WHAT
I REMEMBER IN THE EARLY 1990s,
WHEN I WAS STILL CHIEF OF ORAL
AND FACIAL SURGERY AT THE MASS
GENERAL HOSPITAL, I HEARD FOR
THE FIRST TIME, THE TERM
"COVERED LIVES."
NOT PATIENTS.
AND AT THE SAME TIME, WE STOPPED
CALLING PEOPLE DOCTORS AND BEGAN
TO CALL THEM PROVIDERS.
WELL, COVERED LIVES AND
PROVIDERS HAVE DOMINATED HEALTH
CARE DELIVERY SINCE THAT TIME.
THEODORE ROSE BERRY AND THE
30th ANNIVERSARY OF THE GEIS
REPORT IN 1955, BELIEVE IF OR
NOT, MADE AN INTERESTING
STATEMENT THAT UP UNTIL THAT
TIME, DENTISTRY HAD BIG WINS
I.E. FLUORIDE BUT THEY HAD NOT
DEVELOPED ANY MEDICAL TREATMENTS
OF DISEASE THAT COULDN'T RAID
INDICATE DISEASE AND THAT'S WHAT
WE STILL NEED TO DO AND MEDICINE
HAS BEEN ABLE TO DO IT AND
THAT'S WHY SCIENCE IS MUCH MORE
APART OF MEDICINE THAN IT IS
DENTISTRY UNFORTUNATELY.
HE WAS A SCIENCE ADVISER AND SET
STAGE FOR THE NIH, REALLY
BELIEVED IN SCIENCE AND VIETNAM
WAR, FOR THOSE AT MY AGE,
REMEMBERS THE YELLOW BERETS THAT
WENT TO THE NIH AND BECAME
OUTSTANDING SCIENTISTS AND
THAT'S WHAT YOU ARE TRYING TO DO
AGAIN AND THEN I ALSO REMEMBER
CHANGE IS POSSIBLE.
THE NATIONAL INSTITUTES FOR
DENTAL RESEARCH BECAME THE NEXT
INSTITUTES OF DENTAL AND CRANIAL
FACIAL RESEARCH UNDER Dr.
SLAVKA SO THE ALLIANCE BETWEEN
MEDICINE AND DENTISTRY IS
IMPORTANT AND SIGNALS A
COMMITMENT TO SCIENCE AND I DO
NOT THINK THE STATUS QUO IS
INEVITABLE AND I THINK EDUCATION
AND RESEARCH CAN DRIVE THE
PROFESSION AND THAT IS AN
IMPORTANT ROLE FOR THE NIH AND
THE NIDCR.
NEXT SLIDE.
NEXT, PLEASE.
SO, THERE ARE A LOT OF REPORTS
ON MEDICAL INTEGRATION.
I WROTE THIS IN 1993.
STAKEHOLDERS WHO ARE INTERESTED
IN THIS.
LA CASCADA TALKING ABOUT MEDICAL
DENTAL AND EDUCATION AND WE'VE
STARTED THE HARVARD INITIATIVE
FOR INTEGRATION AND CIPCOH,
CENTER FOR INCOMPETENT
INAUGURATION OF PRIMARY CARE AND
IN FACT, UNDER THIS THE FIRST
DENTAL RESIDENCY IN NEW
HAMPSHIRE HAS BEEN APPROVED AND
WILL START VERY SOON.
CAN YOU IMAGINE THAT?
NO DENTAL RESIDENCIES IN RURAL
NEW HAMPSHIRE.
SO THE QUESTION IS, HOW DO WE
CREATE LEADERS THAT FALLS BACK
TO THE PROGRAM THAT DANA GRAVES
IS RUNNING AND I'M HAPPY TO BE
PART OF IT.
WE NEED MENTORS, WE NEED
HEAR-OUT PROGRAMS AND WE NEED TO
CHANGE THE CULTURE.
THE NEXT, PLEASE.
SO, WE NEED TO CREATE CAT A LID
I CAN MECHANISMS FOR CHANGE.
DUEL-DEGREE PROGRAMS AND PRIMARY
CARE AND IT WAS DESIGNED TO
PERMIT SURGICAL TRAINING AT AN
APPROPRIATE LEVEL OF
RESPONSIBILITY.
WHICH IS ENABLED BY THE MD.
AND THAT IS WHAT THIS
EDUCATIONAL PROGRAM IS ABOUT.
MAKE ORAL HEALTH PART OF OVER
ALL HEALTH AND IN PRACTICE AND
RESEARCH AND SAVE THE ENDANGERED
DENTIST SCIENTISTS, I REALLY
THINK IT'S POSSIBLE.
OTHER IMPORTANT ISSUES.
IT'S BEEN TAKEN ON BY THE WORLD
BUT WE HAVE TO DEAL WITH THE
UNITED STATES.
IT'S VERY IMPORTANT AND WE SEE
BUSINESS PLAYING THIS GAME.
AMAZON BUYING ONE MEDICAL AND
LAST BUT NOT LEAST, WHAT THE
PANDEMIC HAS DONE WITH THE LOSS,
VACANTED BUDGETED FACULTY
POSITIONS IN U.S. DENTAL.
IT'S INCREDIBLE.
WHO IS GOING TO TEACH?
WHO IS GOING TO TEACH THE NEXT
PLEASE.
SO, HERE IS DENTAL EDUCATION
CROSS ROADS INSTITUTE OF
MEDICINE AND 1995.
IF YOU HAVE A CHANCE, READ IT.
GIES REPORT, GOOD REPORT, READ
IT.
INNOVATORS DILEMMA, GREAT BOOK.
READ IT.
BLUE OCEAN STRATEGY.
AN INTERESTING BOOK AND TALKS
ABOUT DIFFERENT WAYS OF THINKING
ABOUT IT AND JUST CONSIDER THIS,
WRING LING BROTHERS BAR LEM AND
BAILEY CIRCUS NO LONGER EXISTS
BUT CIRQUE DU SOLEIL IS THRIVING
SO CHANGE IS POSSIBLE.
MOST OF ALL, THE MOST INNOVATIVE
THING, EVER, IS AN OREO PACKAGE
THAT CAN YOU OPEN BY RIPPING THE
FLAP UP.
>> I REALLY BELIEVE IN THIS AND
THE KEY TO REFORM OF ALMOST ANY
KIND OF HIGHER TED INDICATION
LIES NOT IN THE WAY THAT
KNOWLEDGE IS PRODUCED, IT LIES
IN THE WAY THAT THE PRODUCERS OF
KNOWLEDGE ARE PRODUCED FROM THE
MARKETPLACE OF IDEAS AND BY
LOUIS MENARD WHO TEACHES AT
HARVARD.
IF YOU HAVEN'T READ IT, THIS IS
A RECENT AUGUST EDITORIAL IN THE
JOURNAL OF THE AMERICAN DENTAL
ASSOCIATION AND BY MYSELF AND
THE FUTURE LEASE ASSIGNMENT AND
WHAT NEEDS TO HAPPEN IN DENTAL
EDUCATION.
THANK YOU VERY MUCH AND I'M
HAPPY TO ANSWER ANY QUESTIONS.
>> ARE THERE ANY QUESTIONS.
OR COMMENTS?
>> IT'S TERRY DICK INSON.
SO MANY THINGS YOU SAID -- I
KNOW OF ONE SPOT HEALTH-CARE
SYSTEM IN VIRGINIA AND THEY'VE
DONE THIS FOR A NUMBER OF YEARS
AND THEY HAD A CHAMPION WHICH
YOU SPEAK TO AND THAT'S WHAT YOU
NEED.
THEY'VE REALLY INTEGRATED DENTAL
INTO THE MEDICAL SCHOOL THERE
AND SO YOU ARE RIGHT, THERE'S
NOT MANY OF THEM OUT THERE BUT
THERE ARE SOME OUT THERE BUT IT
DEPENDS SO MUCH ON THAT CHAMPION
THAT IS WILLING TO PUT THE TIME
AND ENERGY AND HEART INTO
GETTING THAT THING TO WORK.
WE JUST HAVE TO KEEP TRYING.
>> THIS IS A GREAT PROGRAM.
>> THANK YOU.
>> AND THEN I WOULD SAY ALSO,
BRUCE, THAT IF YOU REMEMBER THE
DAYS WHEN MARGI, GOD BLESS HER
SOUL, RAN THOSE STUDIES WHERE
SHE COMPARED IT WAS DELTA DENTAL
AND ANOTHER COHORT OF RECORDS
SHE LOCKED AT TO SHOW THAT IF
YOU ACTUALLY TREATED GUM DISEASE
OR PRAIR PERRY TONIGHTAL DISEASU
WERE ABLE TO -- ALLOWS US TO CRE
THE EVIDENCE THAT THAT
INTEGRATION IS NECESSARY, RIGHT.
SO I SEE ANOTHER ADVANTAGE TO
TRAINING INDIVIDUALS AND PORT
LEADERS AND WHO WOULD SAY I'VE
GOT THIS WHOLE PATIENT AND I'M
LOOKING AT EVERYTHING FROM
HEAD-TO-TOE AND NOT CUTTING THE
HEAD AND HAVING IT FLOAT IN
SPACE BECAUSE VISION AND HEARING
IS ALSO LOST IN SPACE SO YEAH, I
SO AM HOPING THAT DAN A. I
ENCOURAGE DANA'S GROUP TO LOOK
AT THIS MODEL AS A TESTING
SYSTEM PERHAPS THAT WE CAN
CONSIDER OUR LAUNCH INTO.
>> THANK YOU FOR ASKING ME TO
SPEAK.
>> Lynn M. King: THANK YOU Dr.
DONOFF.
>> SO, THIS IS JACK FROM
UNIVERSITY OF MICHIGAN AND
EXCELLENT PRESENTATION Dr.
DONOFF.
I WAS INTRIGUED WHEN YOU WERE
TALKING ABOUT THE REVIEW FROM
KAISER PERMANENTE ABOUT GOING
BEYOND TRADITIONAL IPE PROGRAMS
AND CAN YOU EXPAND A LITTLE BIT
MORE ON THAT?
>> WELL, I HAVE NOT VISITED OUT
THERE FOR ABOUT THREE YEARS BUT
THEY HAD CLINICS WHERE THEY
ACTUALLY DID THIS.
THEY HAD PHYSICIANS AND NURSE
PRACTITIONERS WORKING TOGETHER
AND OF COURSE, NOW, KAISER HAS
THEIR OWN MEDICAL SCHOOL IN
PASADENA AND SINCE I KNEW THE
DEAN AT CHILDREN'S HOSPITAL IN
BOSTON I TRIED TO GET TO FORM A
DENTAL SCHOOL BUT HE RAN OUT OF
MONEY AND IN ANY CASE, YEAH, I
THINK THIS CAN WORK.
YOU DON'T HAVE TO BE THE DENTIST
WHO IS GOING TO DO EVERY
PROCEDURE.
BUT YOU CERTAINLY NEED TO BE
SOMEONE WHO LISTENING TO THE
CONVERSATIONS ABOUT OR ALKAN SER
DETECTION TODAY, YOU KNOW, THE
LEADING CAUSE FOR SUITES AGAINST
DENTIST IS NATIONALLY, FAILURE
TO DETECT THE OR ALKAN SER
BECAUSE THEY DON'T LIKE IN THE
MOUTH -- WHAT --
>> OPPORTUNITIES AND MEDICAL AND
TEST IN AND SO THAT WOULD BE
TRAINED TO BE LOOKING AT THOSE
RECORDS FROM A DATA MINING
PERSPECTIVE AS WELL.
>> THANK YOU.
>> THANK YOU, BRUCE.
>> MY PLEASURE, THANK YOU.
>> Lynn M. King: NEXT ON THE
AGENDA WE'RE MOVING FORWARD TO
THE SIX CONCEPT CLEARANCES.
CLEARANCE OF CONCEPTS BY
PRESENTING THE PURPOSE, SCOPE
AND OBJECTIVES IN A PUBLIC FORUM
SUCH AS THE COUNCIL MEETING.
AND GETTING COUNCIL MEMBERS AND
THE PUBLIC AN OPPORTUNITY TO
COMMENT.
FOLLOWING THE PRESENTATIONS BY
NIDCR STAFF, DESIGNATED COUNCIL
MEMBERS WILL BE THE DISCUSSION
FOLLOWED BY A VOTE.
WHBY THE COUNCIL MEMBERS FOR
APPROVAL OF THE CONCEPT AS A
BASIS FOR DEVELOPING A FUTURE
FUNDING OPPORTUNITY
ANNOUNCEMENT.
Dr. AMANDA MELILIO WILL
PROVIDE THE FIRST CONCEPT SHE'S
FROM THE CHIEF OF THE INTEGRATED
PROGRAM OFFICER FOR THE ORAL
OPPORTUNITIES PATHOGENS AND
VIRAL DISEASE PROGRAMS.
>> THANK YOU, LYNN.
AND THANK YOU FOR THE
OPPORTUNITY TODAY TO PRESENT
THIS CONCEPT ON COLLABORATIVE
SCIENCE TO ACHIEVE DESTRUCTIVE,
INNOVATION AND DENTAL, ORAL AND
CRANIOFACIAL RESEARCH AND TODAY
WE'RE SEEKING COUNCIL CLEARANCE
ON THIS CONCEPT.
THE GOAL IS TO ADDRESS
CHALLENGING QUESTIONS WITH
POTENTIAL TO SIGNIFICANTLY
ADVANCE DOC RESEARCH FIELDS.
WE NEED TO MOVE AWAY FROM A
REDUCTIONIST VIEW OF SCIENCE AND
TRANCE DIS PLAIN ARY TEAMS ARE
REALLY NEEDED TO MAKE THIS
SHIFT.
SO, I NEED TO THANK SOME OF THE
EARLIER SPEAKERS TODAY FOR
SETTING UP THIS CONCEPT SO
NICELY AND AS Dr. D D'SOUZA TALD
ABOUT COLLABORATIVE TEAM SCIENCE
APPROACH IS REALLY ESSENTIAL IN
MOVING SOME AREAS OF SCIENCE
FORWARD.
SO, I WOULD ALSO JUST LIKE TO
REITERATE WHAT Dr. CARTER
MENTIONED EARLIER THAT
INDIVIDUALS DRIVEN OVATION BUT
IT TAKES A TEAM TO TACKLE A
COMPLEX PROBLEM AND THAT IS
EXACTLY WHAT THIS INITIATIVE IS
TRYING TO DO.
IN ADDITION TO THAT, WE ALSO SAW
EXCELLENT EXAMPLES OF TEAM
SCIENCE IN RESPONSE TO THE
COVID-19 PANDEMIC.
WHEN THERE WERE UNPRECEDENTED
SCIENTIFIC COLLABORATIONS AS
EXPERTS FROM AROUND THE WORLD
CAPE TOGETHER ASK COLLABORATED
TO FACE THAT CAUSE AND THE
PANDEMIC.
SO THERE'S A NUMBER OF
ADVANTAGES TO TEAM SCIENCE.
THESE INCLUDE ADVANCING
SCIENTIFIC ASK TECHNOLOGY
INNOVATIONS BY INCREASING
RESEARCH IMPACT AND NOVELTY AND
PRODUCTIVITY AND THEN A TEAM
SCIENCE APPROACH IS MORE LIKELY
TO PUT NOVEL COMBINATIONS OF
WORK TOGETHER AND TO DEVELOP
WORK THAT INTEGRATES NOVEL IDEAS
INTO HIGH-IMPACT OUTPUTS.
TEAM SCIENCE CAN HELP BROADEN
THE REACH OF RESEARCH FINDINGS
ACROSS AREAS OF SCIENCE COMPARED
TO TRADITIONAL APPROACH AND HELP
SPEED THE GENERATION AND
DISSEMINATION OF KNOWLEDGE.
IT CAN HELP INCREASE DIVERSITY
OF PARTICIPANTS, RESEARCHERS,
AND THE RESEARCH QUESTIONS.
SO YOU MIGHT BE ASKING
YOURSELVES, HOW WILL THIS
COMPARE TO OTHER MULTI-P.I.
AWARDS.
SO THE TRADITIONAL M.P.I. AWARD
ARE TYPICALLY P.I.s CAN
DIFFERENT DISCIPLINES WORKING
TOGETHER, DRAWING ON THEIR
DISCIPLINARY KNOWLEDGE AS
ILLUSTRATED BY THESE INDIVIDUALS
CIRCLES ON THIS GRAPH.
AND THIS IS MORE TYPICAL FOR
YOUR TRADITIONAL INVESTIGATOR
INITIATED RESEARCH AND IN THOSE
TYPE OF FUNDING OPPORTUNITIES,
THERE'S ALSO NO REQUIREMENT TO
HAVE P.I.s WORKING TOGETHER
ACROSS DISCIPLINES AND SO IN
THESE TYPE OF SETTINGS, THE P.,
WORKS LARGELY INDEPENDENTLY AND
ON A RESEARCH PROBLEM IN THEIR
OWN LAB.
SO, NEXT CLICK, PLEASE.
WHILE PROGRAM PROJECT AWARDS,
THEY BRING TOGETHER MULTIPLE
INDEPENDENT ANT PROJECTS IN A
GRADING KNOWLEDGE FROM DIFFERENT
DISCIPLINES.
WHILE EACH GROUP BRINGS
EXPERTISE TO ADDRESS THE
RESEARCH PROBLEM THEY'RE WORKING
ON SEPARATE SCIENTIFIC PARTS OF
THE PROBLEM WHICH ARE LATER
INTEGRATED.
NEXT CLICK, PLEASE.
WHILE A TRUE TEAM SCIENCE
APPROACH, WE'RE LOOKING AT A
SINGLE WELL INTEGRATED RESEARCH
PLAN WITH A SINGLE DISCIPLINARY
PERSPECTIVE.
AND THIS ALLOWS FOR AN
INTEGRATED TEAM TO BRING
COMPLIMENTARY APPROACHES TO
ACCOMPLISH A UNION FIGHT
SCIENTIFIC GOAL SO WE'RE REALLY
THINKING ABOUT THAT UNIFIED
SCIENTIFIC GOAL HERE AND THIS
INTEGRATED EFFORT WOULD BE
REQUIRED TO HAVE THREE TO SIX
P.I.s WHO WOULD EACH BRING
SCIENTIFIC EXPERTISE AND THE
PROJECT SHOULD BE COHESIVE AND
WELL DEFINED AND A FOCUS ON A
INDIVIDUAL RESEARCH GOAL THAT IS
EXPECTED TO YIELD A SPECIFIC
OUTCOME OR DELIVERABLE BY THE
END OF THE PROJECT PERIOD.
SO THIS IS NOT MEANT FOR AN
INCREMENTAL ADVANCEMENTS.
AND FURTHERMORE, THIS CONCEPT
SUPPORTS THE IDEA OF BRINGING
TOGETHER NEW INTERSECTIONS OF
EXPERTISE AND THEY DID NOT
PREVIOUSLY EXIST REGARDLESS OF
THE TEAM OF INVESTIGATORS IS
NEWLY COLLABORATING OR HAS
COLLABORATED IN THE PAST.
NEXT SLIDE, PLEASE.
SO, AS I MENTIONED, THE GOALS TO
ADDRESS AMBITIOUS AND CHARGING
RESEARCH QUESTIONS OF HIGH
PRIORITY TO NIDCR.
SO THE FIRST SET OF CHALLENGING
AND DISRUPTIVE TOPICS THAT THIS
CONCEPT WILL ADDRESS ARE THE
FOLLOWING -- PATIENT-CONTROLLED
TECHNOLOGIES TO REDUCE HEALTH
DISPARITIES AND THEY SHOULD DRAW
BEST PRACTICES FROM OTHER
FIELDS.
MEDICINE TO IMPROVE ORAL HEALTH.
NOVEL APPROACHES FOR PREVENTION
OF CHILDHOOD CARRIES TO
SIGNIFICANTLY REDUCE INCIDENTS
OF DISEASE.
NOVEL NON OPIOID FARM OWE
THERAPY APPROACHES FOR
DOC-RELATED PAIN THAT MINIMIZES
SIDE EFFECTS AND DENTAL
RESTORATIVE SYSTEMS WITH LIFE
THAT EXCEEDS COMMERCIAL
MATERIALS AND NOVEL APPROACHES
TO ADVANCE PREVENTION AND
THERAPEUTICS STRATEGIES TO
MANAGE HIV AND ITS ORAL
MANIFESTATIONS AND
CO-MORBIDITIES.
AS YOU CAN ENVISION, ALL THESE
TOPICS WOULD REALLY BRING
TOGETHER VARIOUS INTERSECTIONS
OF EXPERTISE TO REALLY COME UP
WITH INNOVATIVE AND DISRUPTIVE
WAYS TO SOLVE THESE PROBLEMS.
AND FOR EXAMPLE, ONE CAN
ENVISION THAT A
PATIENT-CONTROLLED TECHNOLOGIES
TO REDUCE HEALTH DISPARITIES
WOULD INVOLVE ENGINEERS,
CLINICIANS, BEHAVIORAL
SCIENTISTS, PERHAPS
MICROBIOLOGISTS IF THE
TECHNOLOGY WAS IN THE INTRA ORAL
ENVIRONMENT AND THROUGH ALL
THESE RESEARCH OPPORTUNITIES, WE
ALSO THINK THAT THERE SHOULD BE
A FOCUS ON DATA SCIENCE AND THAT
REALLY IS CRUCIAL SO INVOLVEMENT
OF DATA SCIENTISTS ARE
COMPUTATIONAL BIOLOGISTS IS ALSO
SEEN AS AN ESSENTIAL PART OF
THIS.
SO NEXT SLIDE, PLEASE.
FROM HERE I WILL TURN IT OVER TO
THE THREE CONCEPTS COUNCIL
REVIEWERS AND I'M HAPPY TO THEN
ADDRESS ANY QUESTIONS.
>> WHICH ONE OF WOULD YOU LIKE
TO PRESENT FIRST?
>> I WILL.
>> I WOULD LIKE TO.
>> SO, THANK YOU.
I HAVE A LOT OF ENTHUSIASM FOR
THIS CONCEPT.
I THINK IT'S VERY ATTRACTIVE FOR
SEVERAL REASONS.
I DON'T THINK ANY OF THIS WOULD
DISAGREE THAT TEAM SCIENCE IS
REALLY COME TO THE FOREFRONT AND
WE ALL UNDERSTAND THE POWER OF
THAT.
THIS PARTICULAR MECHANISM IS
UNLIKE ANY OTHER NIDCR MECHANISM
AND THAT IS WHERE THE POWER
LIES, I THINK, IN THE FACT THAT
IT REQUIRES, AS AMANDA SAID, A
SINGLE, WELL INTEGRATED
QUESTION.
AND BRINGING SCIENTISTS TOGETHER
IN THIS WAY, IN THIS TYPE OF
TEAM, WHERE THEY ALL ARE
BRINGING THEIR EXPERTISE TO BEAR
ON A SINGLE UNIFIED VERY
IMPORTANT PROBLEM, IS SOMETHING
THAT I THINK IS LIKELY TO BE
VERY -- TO CREATE VERY
TRANSFORMATIVE DISCOVERY AND
KNOWLEDGE AND I WILL SAY THE
POSSIBLE ISSUES I SEE ARE IT
WILL TAKE SOME TIME FOR PIs TO
UNDERSTAND THIS MECHANISM AND
WE'RE USED TO MORE TRADITIONAL
MECHANISMS, MULTI P.I.s AND AS
MENTIONED, OR PROGRAM PROJECTS
WITH INDIVIDUAL PROJECTS THAT
HAVE SYNERGY AND HERE, EVERYONE
COMES TOGETHER AND WORKS
TOGETHER.
SO, I THINK IT WOULDN'T BE A
SURPRISE IF THERE'S KIND OF A
LEARNING PERIOD FOR THE
APPLICANTS AND I THINK THAT WITH
EDUCATION, FREE EDUCATION AS I
KNOW THAT YOU WILL DO, THEY WILN
WHAT THIS MECHANISM IS ABOUT AND
HOW TO CONSTRUCT A SUCCESSFUL
PROJECT.
AND ALSO, MANAGEMENT OF THE TEAM
WILL BE CRITICAL AND PERHAPS
MANAGEMENT OF 24 TYPE OF TEAM
WHERE THERE ARE PIs ALL
WORKING VERY CLOSELY TOGETHER,
WITH NO ONE SINGLE P.I.s IS
SOMETHING THAT MIGHT BE A LITTLE
FOREIGN TO SOME P.I.s SO,
THOSE ARE MY COMMENTS AND IN
ADDITION, I THINK WE HAD
DISCUSSED THAT PERHAPS THE
TARGET AREAS SHOULD BE REVISITED
FAIRLY FREQUENTLY SO THAT YOU
SELECT THOSE THAT ARE LIKELY TO
BENEFIT FROM THIS MECHANISM, THE
MOST AND BE THE MOST FRUITFUL.
>> THANK YOU.
>> SO, I GROW WITH EVERYTHING
THAT WAS SAID.
I THINK THIS IS A REALLY
IMPORTANT CONCEPT.
SO, JUST TO ADD A LITTLE BIT OF
PERSPECTIVE.
MY GROUP IS LOCATED NOT AT A
UNIVERSITY BUT AT A NATIONAL LAB
WHERE WE HAVE HISTORICALLY USED
TEAM SCIENCE APPROACH TO TACKLE
GRAND CHARGE AND SCIENCE THAT
TEND TO BE TOO DIFFICULT TO
SOLVE BY INDIVIDUALS SINGLE
INVESTIGATORS GROUPS.
AND SO HERE AT THE NATIONAL LAB
THIS APPROACH REALLY AROSE OUT
OF PHYSICAL TICKS RESEARCH WHERE
THE NEED TO LARGE SHARED
IMPLEMENTATION PROGRAMS NEED TO
ASSEMBLE THESE
MULTI-DISCIPLINARY TEAMS AND
FIND WAYS TO INCENTIVISE AND
REWARD THEM IN WORKING CLOSELY
TOGETHER BUT THIS HAS GUN A MORE
RECENTLY APPLIED WITH GREAT
SUCCESS AND THE BIOMEDICAL SPACE
SO MOST ♪LY NOTELY FOR THE GENOE
INSTITUTE IT'S MY PERSONAL
PERSPECTIVE AND WHY I AM SO
APPRECIATIVE OF THIS AND ALSO,
TO BE PART OF THE FAITH-BASED
CONSORTIUM SINCE THE INCEPTION A
DECADE AGO AND I'VE SEEN
BRINGING TOGETHER
MULTI-DISCIPLINARY RESEARCHERS
AND FACILITATED BY A SUSTAINABLE
AND SUPER FUNDING STRUCTURE AND
DESIGNED TO FOSTER SUCH
COLLABORATION IN OTHER AREAS OFF
THE MISSION MOVING FORWARD AND I
THINK THAT IT WILL CREATE
IMPACTFUL OUTCOMES MY ONLY
COMMENT IS THAT I WOULD
ENCOURAGE NIDCR TO CONSIDER NOT
RESTRICTING ITS STRICTLY TO THE
FIVE FOCUS AREAS WITHOUT THE
SCOPE TO THOSE.
THAT SAID, WITH OR WITHOUT I'M
EXCITE BESIDE THIS CONCEPT AND
FULLY SUPPORTIVE.
>>
>> HE COMPLA EXPLAINED OUR SUPPE
ARE IN DEEP SUPPORT FOR
ENCOURAGEMENT OF THIS TEAM
SCIENCE AND I WILL JUST
REITERATE THAT YEAH, I THINK
THAT HAVE ANYTHING TO ADD.
THIS ISSUE OF THE HAVING TO
DEFINED AREAS I DO THINK IT'S
SOMETHING THAT ALL OF US HAVE A
LITTLE BIT OF QUESTIONS ABOUT
AND -- WITHOUT HAVING TO DECIDE
WHAT THOSE TOPICS ARE.
>> ANY COMMENTS OR QUESTIONS
ABOUT THIS CONCEPT?
>> I HAVE A COMMENT.
ONE IS THAT THERE WILL NEEDS TO
BE A MECHANISM TO SHARE CREDIT
FOR APPOINTMENT AND PROMOTIONS
IT'S VERY IMPORTANT TO BE P.I.
AND YOU HAVE TO IDENTIFY THEM AS
P.I.s AND THE CREDIT IS NOT
SHARED EQUALLY IS.
>> SO IT IS AN PMI THERE'S A
CONTACT PI AND OTHER PIs AND
IT'S A LESSER STATUS AND IT'S.
>> I AGREE WITH YOU AND YOU ARE
COMING FROM A PRACTICAL
STANDPOINT WHICH IS OUR
UNIVERSITY ISSUE, RIGHT.
>> YES.
>> IT'S REALLY UNIVERSITIES NEED
TO GRAPPLE WITH THIS ISSUE AND
IT'S UNTORT AT AND THE CHANGE
AND FOR THE UNIVERSITY LEVEL.
IS THAT WAY OF CHANGE SWEEPING
THROUGH AND THAT IT'S FROM THE
SUCCESS OF HIGH-RISK HIGH GAIN
THAT ARE DISRUPTIVE THAT'S HOW
THE GPS WAS CREATE AND SOL, THEY
JUST APPOINTED AND PRESIDENT
JUST ANNOUNCED HIS CHOICE FOR
DIRECTOR OF ARPA-H WHICH USES
REALLY THE PRINCIPLES CAPTURED
IN THIS CONCEPT AND SO KEEPING
AN EYE OUT ON.
>> -- SO THERE ARE OPPORTUNITIES
FOR US HERE.
>> YEAH, I'M JUST ECHOING THAT
SPECIFICALLY THIS TYPE OF
APPROACH HAS BEEN DONE RECENTLY
AT A FEW DIFFERENT INSTITUTES
ACROSS NIH AND THEY ARE ALL
RELATIVELY NEW SO NIH EMS WAS
THE FIRST TO PUT A MECHANISM
SIMILAR TO THIS FORWARD AND
NIDCR AND PUT THIS OUT AS WELL
THIS YEAR.
>> AND DO YOU SEE THE PROSPECT
OF PARTNERING WITH NIDCR AND
WAMC HAS A BIG ROLE IN CREATING
IS THAT LEVEL PLAYING FIELD IN
AK DEEMIA SO THAT TEAM SCIENCE
IS NOT SQUISHED OR DEVALUED.
AND THEY CAN CHANGE CULTURE IN
AN INSTITUTION.
>> BEYOND ALL SCOPE.
>> SOME OF THE REST OF US SHOULD
DO THAT TOO.
>> I'VE GIT'S A CHANGE,ABSOLUTE.
I WANTED TO SAY --
>> JUST SOME OF MY EXPERIENCE,
I'VE HAD SOME EXPERIENCE WITH
THE NIGMS MECHANISM AND THAT'S
MY COMMENTS THAT PI IS NOT
REALLY UNDERSTANDING THE
MECHANISM CAME FROM BECAUSE
EARLY ON THERE, A LOT OF THE
APPLICATIONS LOOK LIKE PROGRAM
PROJECT GRANTS AND WE WERE WOVEN
TOGETHER BUT IT WASN'T REALLY
WHAT THE MECHANISM WAS AFTER SO
PERHAPS WE CAN LEARN FROM THAT.
>> YEAH.
DEFINITELY.
AND THAT IS WHAT I WAS GOING TO
SAY TOO.
WE CAN ALSO CERTAINLY WE CAN
DISCUSS WITH MY COLLEAGUES AT
NIGMS ABOUT THE EXPERIENCE OF
THE MULTI-PI APPROACH AND THE
TEAM SCIENCE APPROACH AND HOW IF
THEY FEEL THEY'VE SEEN EFFECTS
AT THE UNIVERSITY LEVEL OF
CREDIT AND THAT AND AS Dr.
GRAVES MENTIONED.
>> THANK YOU.
>> AND MAYBE -- MAYBE WE ALL THE
TO HAVE AN WEBINAR ON CONDITION
FOLKS.
>> ABSOLUTELY.
THAT IS PLANNED AS PART OF THIS.
>> THANK YOU.
>> Lynn M. King: ANYTHING ELSE?
ANY OTHER COMMENTS?
WE CAN MOVE ON TO DOES A
COUNCILMEMBER LIKE TO MAKE A
MOTION TO APPROVE THIS CONCEPT?
>> I WOULD LIKE TO MAKE A
MOTION.
>> LEE.
>> THANK YOU.
>> AND WOULD ANYONE LIKE TO
SECOND?
>> I CAN SECOND IT.
JACK.
ALL IN FAVOR.
>> AYE.
ANY OPPOSED?
THANK YOU, AMANDA.
>> THANK YOU.
>> Lynn M. King: THE NEXT
CONCEPT WILL BE PRESENTED BY
CENTER MARGARET GRISIUS.
AND THE CLINICAL TECHNOLOGIES
RESEARCH PROGRAM.
SHOULD SHE WILL PRESENT ON
MATERNAL HEALTH AND DENTSAL AND
ORAL AND CRANIOFACIAL HEALTH AND
DEVELOPMENT OF THEIR OFFSPRING.
>> GOOD AFTERNOON, THANK YOU FOR
THE OPPORTUNITY TO PRESENT
TODAY.
I'M SEEKING COUNCIL'S
CONCURRENCE ON THE CONCEPT TITLE
MATERNAL HEALTH IN THE DENTAL
ORAL AND CRANIOFACIAL HEALTH AND
HAVEMENT OF THEIR CHILDREN.
THE MATERNAL MORBIDITY AND
MORTALITY RATE IN THE UNITED
STATES IS ONE OF THE HIGHEST IN
THE WORLD.
MATERNAL MORBIDITY AND MORTALITY
HAS BEEN ASSOCIATED WITH POOR
PRE-NATAL CARE AND LIMITED
ACCESS TO HOSPITALS.
IT'S RECOGNIZED THE HIGHEST
RATES OF MATERNAL MORBIDITY AND
MORTALITY, DISPROPORTIONATELY
IMPACTS THE UNDER REPRESENTED
MINORITIES, LOWER SOCIOECONOMIC
AND RURAL POPULATIONS.
THERE'S A NATIONWIDE
PUBLIC-HEALTH AWARENESS OF THE
NEED TIME PROVE MATERNAL HEALTH.
THE NIH OFFICE OF THE DIRECTOR
OFFICE OF WOMEN'S HEALTH AND THE
INSTITUTE OF CHILD HEALTH AND
HUMAN DEVELOPMENT, ARE CURRENTLY
LEADING THE TASK FORCE ON
MATERNAL MORTALITY.
THE WHITE HOUSE IS RECENTLY
RELEASED THE WHITE HOUSE
MATERNAL HEALTH BLUE PRINT THAT
OUTLINES ACTIONS UNDERTAKEN TO
IMPROVE MATERNAL CARE.
MATERNAL HEALTH IMPACTS THE
MOTHER BUT IMPACTS THE
DEVELOPING CHILD.
MATERNAL HEALTH AND EXPOSURE
HAVE BEEN LINKED TO DOC IN THEIR
CHILDREN AND AND HYPO PLAY SHA
AND FOR EXAMPLE, CHILDREN WHOSE
MOTHERS WERE INFECTED WITH ZIKA
VIRUS DURING PREGNANCY, OFTEN
SUFFERED FROM MICROCEPHALY AND
THE TEETH AND CRANIAL STRUCTURES
ARE DEVELOPING IN UTERO AND IT
MAYING LINKED TO MATERNAL
EXPOSURES, FOR EXAMPLE, IN THE
PRIMARY DEN ADVERTISE HAS BEEN
ASSOCIATED WITH DIFFERENCES IN
MATERNAL AND MEET OWE NATAL
HOMEOSTASIS AND IN THE EX TEETH
OF CHILDREN WHOSE MOTHERS
EXPERIENCED STRESS DURING
PREGNANCY.
EX FOLEYATED TEETH HAVE BEEN
USED TO INDICATE MATERNAL
EXPOSURES AND THE INTENSITY OF
THE EXPOSURE PROVIDING A WINDOW
TO FETAL EXPOSURE.
THE GOAL OF THIS INITIATIVE IS
TO SUPPORT RESEARCH ON PRE-NATAL
ENVIRONMENT AND PHYSICAL
STRESSORS EXPERIENCED DURING
PREGNANCY THAT EFFECT THEIR
CHILD'S DENTAL, ORAL AND
CRANIOFACIAL DEVELOPMENT THROUGH
ALTERED MATERNAL PHYSIOLOGY.
GAPS EXIST IN THE UNDERSTANDING
OF THESE LINKS BETWEEN MATERNAL
PRE-NATAL HEALTH AND EXPOSURE
AND DOC.
EXAMPLES INCLU INDIABETES, LOOPD
INFECTIOUS ACCIDENTS AND
EXAMPLES OF MATERNAL PRENATAL
EXPOSURES INCLUDE TRAUMA,
DIETARY HABITS, HIGH PROCESSED
FOODS, OR VEGAN DIET,
PRESCRIPTION MEDICATIONS,
SUBSTANCE EXPOSURES, PERHAPS DUE
TO UNMONITORED WELL WATER,
TOBACCO PRODUCTS, CANNABIS OR
OPIOIDS.
THIS IS AN OPPORTUNITY TO
IDENTIFY MECHANISMS THAT MAY
HAVE MODIFY AND RISK FACTORS AND
LEAD TO THE DEVELOPMENT OF
POTENTIAL DIAGNOSTIC AND
MODALITIES WITH OTHER NIH
INSTITUTES AND OFFICES AND WE'RE
SEEKING THEIR COLLABORATION.
>> OBSERVATIONAL AND MECHANISTIC
STUDIES OF PREGNANT MOTHERS WHO
HAVE UNDERGONE EMOTIONAL EXPRESS
AND THE IMPACT ON DEVELOPING
TEETH AND CRANIOFACIAL
STRUCTURES OF THEIR OFFSPRING.
AND THE CHILD DENTAL AND
CRANIOFACIAL DEVELOPMENT TO GAIN
A BETTER UNDERSTANDING OF
UNDERLYING DISEASE MECHANISMS
AND OBSERVATIONAL AND
MECHANISTIC STUDIES MONITORING
THE MATERNAL PRE-NATAL EXPOSURE
AND THE KOC DEVELOPMENT OF THEIR
CHILDREN.
-- DOC DEVELOPMENT OF THEIR
CHILDREN.
I'M HAPPY TO TAKE QUESTIONS.
THE DESIGNATED REVIEWERS AND
BELIEVE Dr. NICEWONGER WAS
GOING TO INITIATE THE
CONVERSATION.
>> GREAT, THANK YOU VERY MUCH.
I WANT TO SAY THAT AS REVIEWERS,
WE HAVE A LOT OF ENTHUSIASM FOR
THIS CONCEPT RELATE TODAY
MATERNAL HEALTH AND IMPACT ON
FETAL AND CHILDHOOD DEVELOPMENT.
IT'S REALLY TIMELY.
I MEAN WE HEARD THIS MORNING
DURING THE REPORT ABOUT HOW
THERE'S RENEWED EMPHASIS AND
FOCUS ON THE WHITE HOUSE AND
NIDCR AND OTHER AGENCIES ON
IMPROVING MATERNAL HEALTH SO THE
POTENTIAL FOR PARTNERSHIPS AND
IS REALLY HIGH AND ALSO, THE
TECHNOLOGIES AND THE RESOURCES
THAT HAVE ARE COMING TO THE
FOREFRONT TO WE CAN MOVE FROM
OBSERVATIONAL STUDIES TO THESE
MECHANIC NICE TICKS AND INSIGHTS
OF THE EFFECT OF MATERNAL HEALTH
ON DOC TISSUE FORMATION SO I
APPLAUD THIS CONCEPT AND THE
GOALS ARE GREAT AND THE RESEARCH
ON HOW THE MATERNAL HEALTH AND
PHYSICAL STRESSORS CAN EFFECT
THE CHILDREN AND THEIR DENTAL,
ORAL AND CRANIOFACIAL
DEVELOPMENT.
AS REVIEWERS, THE CONCEPT WAS
ALREADY WELL DEFINED AND I THINK
WE JUST HELPED TO REFINE IT A
LITTLE BIT MOSTLY IN TERMS OF IS
HELPING DRAW IN AND OUTSIDE AND
THE TRADITIONAL AREAS AND MIGHT
BE IT WOULD BE PART OF THIS AND
ALSO HIGHLIGHTING THE STUDY OF
IMPACTS TO THE EMOTIONAL STRESS
DURING PREGNANCY WOULD BE VERY
WELCOME.
AND SO, I'LL TEND IT THAT AND
LET AMY AND THEIR THOUGHTS BUT
WE'RE ENTHUSIASTIC ABOUT THIS.
I CAN ADD THAT YOU DID A GREAT
JOB.
I THINK YOU COVERED OUR WHOLE
CONVERSATION THAT WE HAD AND.
>> I KIND OF LIKEN IT TO THE
REIGNS ON A TREE ABOUT WHAT GOES
ON IN THE LIFE OF THAT TREE.
WHAT COULD WE LEARN THAT WE CAN
IN FACT WHAT HAPPENS BEFORE
SOMEONE GETS PREGNANT EVEN.
TO BE ABLE TO PREDICT WHAT'S
GOING TO MAP DOWN THE ROAD.
WE JUST DON'T HAVE ANYTHING AS
FAR AS I KNOW THAT ADDRESSES
THAT SO I'M REALLY ENTHUSIASTIC
ABOUT IT AND I FULLY SUPPORT
THIS PROJECT.
>> ANYBODY ELSE HAVE QUESTIONS
OR COMMENTS?
ABOUT THIS CONCEPT?
>> RENA.
>> I THINK THE STRIKING DATA
THAT DIANA BIAN BIANCHI, THE MOL
TEE MORBIDITY AND MORTALITY WAS
MOST PREVALENT IN AFRICAN
AMERICANS WOMEN.
THEY WERE THE MOST VULNERABLE
AND SO THAT DISPARITIES ISSUE
PREVAILS AND OBVIOUSLY EFFECTS
THE POPULATION.
AND IT'S PROBABLY A CORRELATION
WITH PERINATAL AS WELL AND
INFANT A DEATHS.
WHY SI DON'T SEE THATDATA.
>> Lynn M. King: ANY OTHER
COMMENTS?
>> OK, ARE WE READY TO VOTE.
DOES ANYONE HAVE -- WOULD
SOMEONE LIKE TO MAKE A MOTION TO
APPROVE THIS CONCEPT?
>> I WOULD LIKE TO MAKE A MOTION
TO APPROVE.
>> Lynn M. King: THANK YOU, LEE.
>> ANYONE SECOND?
>> I CAN SECOND IT.
HAL.
>> ALL IN FAVOR.
AYE.
>> Lynn M. King: ANY OPPOSED?
OK.
THANK YOU.
>> THANK YOU, VERY MUCH.
>> NEXT CONCEPT WILL BE
PRESENTED DID I Dr. HONGEN
YIN, THE PROGRAM OFFICER FOR THE
HIV/AIDS AND ORAL HEALTH
RESEARCH PROGRAM.
AND THE REVIEWERS FOR HER
CONCEPT WILL BE --
THANK YOU.
GO AHEAD AFTERNOON.
THANK YOU FOR THIS OPPORTUNITY
TO PRESENT THE CONCEPT.
UNDERSTANDING PERSISTENT ORAL
HPV AND HIV CO-INFECTION AND ITS
ROLE WITH OROPHARYNGEAL CANCER
INDUCTION.
THIS IS FOR THE EPIDEMIOLOGY
STUDIES IN THE AREA AND THE GOAL
FOR THE CURRENT CONCEPT IS TO SP
IS ITS BETTER RESEARCH FOR PER
IS THE ANT ORAL HIV AND HPV AS
WELL AS ITS ROLE IN THE
INDUCTION AND PATHOGENESIS OF
HPV ASSOCIATED OR CANCER.
PEOPLE WITH HIV HAVE A GREATER
RISK TO GET INFECTIONS SUCH AS
ORAL HPV INFECTION WHICH WAS TWO
TO FOUR COMPARED WITH HIV
INACTIVE INDIVIDUALS.
RECENT SYSTEMIC REVIEWS AND THE
ANALYSIS SHOWED A STRONG
EPIDEMICOLOGY EVIDENCE OF THE
SYNERGISTIC RELATIONSHIP BETWEEN
THESE TWO VIRUSES.
ALTHOUGH THE BIOLOGY
RELATIONSHIP WOULD NOT WELL
STUDIED.
SO BESIDES THE HIGH-RISK OF CO
INFECTION, WHAT IS IMPORTANT TO
UNDERSTAND THIS WAS TO SHOW THAT
MORE THAN 20% OF OROPHARYNGEAL
CANCER SHOW HPV INFECTION AND
PEOPLE WITH HIV, THIS INSTANCE
INCREASES TO 80%.
SO, THE GR STATISTICS ENCOURAGEU
TO ADVANCE RESEARCH IN THIS
FIELD.
IS FOCUSING ON THE (INAUDIBLE)
IT'S KNOWN THAT ALL ORAL MUCOSAL
EP THEILIA IS A PERFECT IMMUNITY
BARRIER TO PROTECT INFECTIONS,
INFLAMMATION AND CORRAL CANCER
HOWEVER, ORAL HPV INFECTION CAN
DAMAGE THIS IMMUNITY BARRIER BY
BOOST INNATE AND ADAPTIVE
IMMUNITY IN ORAL EP THEILIA.
ALTHOUGH THE THERAPY BROUGHT A
REVOLUTIONARY IMPROVEMENT IN
TERMS OF MY CONTROL, THAT CAN
DAMAGE WITH EPITHELIA BARRIER
AND THE WORSE CASE SCENARIOS THE
LAWS OF ORAL MUCOSAL EPITHELIAL
IN HOMEOSTASIS IS IN CANCER
INDUCTION AND WITHOUT
PROTECTION, HIGH-RISK HPV ACCESS
THAT EPITHELIAL CELLS IN
INTEGRITY TO THE HOST GENOME
WHICH IS ONE OF THE MOST
CRITICAL STEPS FOR CANCER
DEVELOPMENT.
DESPITE ALL THIS STRONG
EVIDENCE, THERE ARE GAPS IN OUR
UNDERSTANDING OF THE
PATHOGENESIS RELATED TO THE
PERSISTENT ORAL HPV AND HIV CO
INFECTION AS WELL AS HOW IT
CONTRIBUTED TO THE INDUCTION OF
OROPHARYNGEA.
>> Marla: CANCER AND IT
PROVIDES INSIDE INFORMATION FOR
MECHANISTIC TARGETS CAN FURTHER
GUIDE THE DEVELOPMENT OF MORE
EFFICIENT PREVENTIONS AND THE
THERAPEUTICS.
SO HERE I'M OFFERING SOME
SPECIFIC AREAS OF INTEREST THAT
COULD FEED THE SCOPE OF THIS
CONCEPT.
WE CONTINUE TO ENCOURAGE
STUDYING THE EPIDEMIOLOGY AND
BIOLOGY OF ORAL HPV PERSISTENT
AND PROGRESSION IN PEOPLE WITH
HIV.
THE HIGH-RISK FACTORS SUCH AS
AGE, SOCIAL DETERMINATION AND
WHAT EFFECTS THIS VULNERABLE
POPULATION.
AND TO REITERATE THIS CONCEPT IS
FOCUSING ON THE MECHANISTIC
STUDIES INCLUDING STUDIES
EXPLORING THE EPIDEMIOLOGY AND
BIOLOGY FOR SYNERGISTIC
RELATIONSHIPS BETWEEN HIV AND
ORAL HPV INFECTIONS.
FOR EXAMPLE, IN STUDIES AND
ANIMAL STUDIES TO DETERMINE THE
THIS TWO VIRUSES AND STUDIES AND
AND ATTEND HIV INFECTION EFFECTS
ORAL HPV SUCH AS ORAL PROFILE
IMMUNOLOGY AND DYNAMIC
PATHOGENIC.
STUDIES EVALUATING THE IMPACT OF
ORAL MICRO BILE AND THE IMMUNE
PATHOGENIC CHANGES ASSOCIATED
WITH ORAL HPV ACQUISITION AND
PERSISTENCE AND PEOPLE WITH HIV.
AND LAST BUT NOT LEAST, STUDIES
AND COVERING THE PATHOGENESIS OF
ONCO-IMMUNOLOGY ON HOW
CONTRIBUTE TO THE INDUCTION OF
HPV-ASSOCIATED OROPHARYNGEAL
CANCER.
BIOMARKERS, MOLECULE DRIVERS AND
THE COMPONENTS AND PATHWAYS THAT
CONTRIBUTE TO THIS PATHOGENIC
PROGRESSION.
TO TAKE THE MESSAGE, I
APPRECIATE A COUNCIL'S DURATION
TO APPROVE THIS CONCEPT WHICH IS
TRYING TO ADDRESS AN IMPORTANT
PUBLIC-HEALTH AND CLINICAL
PROBLEM.
I JUST SINCERELY ACKNOWLE A ACKE
DOCTOR FOR THEIR VALUABLE TIME
ON THIS CONCEPT.
I'M TAKE QUESTIONS AND COMMENTS,
THANK YOU.
>> THANK YOU, AGAIN.
>> I CAN GET STARTED.
SO, I AM STRONG SUPPORT FOR THIS
CONCEPT.
WE'VE KNOWN FOR MANY YEARS THAT
PATIENTS WITH HIV HAVE INCREASES
FOR SARCOMA BUT AS PEOPLE WITH
HIV ARE LIVING MUCH LONGER NOW,
WITH THE SUCCESS OF THE THERAPY
WE'RE STARTING TOE SEE THAT THIS
PATIENTS ARE ALSO A LOT
INCREASED RISK FOR ORAL FAR
HANGAL CANCER WHICH HAS BEEN CA.
THE RELATIONSHIP WE KNOW HIV AND
HPV NEEDS TO BE MUCH BETTER
UNDERSTOOD IN ORDER FOR US TO
UNDERSTAND THE PATHOGENESIS OF
THIS DISEASE IN THIS PATIENTS
WITH HIV AND COME UP WITH A
BETTER PREVENTATIVE STRATEGIES
AND SO SHE DID A WONDERFUL JOB
PUTTING TOGETHER THESE CONCEPT
AND I THINK THIS IS SPECIFIC
AREAS OF INTEREST AND ARE
FOCUSED ON STUDIES THAT LOOK AT
BETWEEN THE TWO VIRUSES AND THIS
CAN BE IMPORTANT STUDIES FOR
THESE FIELD SO I THINK THAT THIS
IS A VERY TIMELY CONCEPT AND
HIGHLY SIGNIFICANT AND
ESPECIALLY IN LIGHT OF THE MANY,
MANY CASES THAT WE'VE SEEN OF
PATIENTS WITH ORROPHARYNGEAL
PATIENTS AND POSITIVE PATIENTS
WHO HAVE CANCER SO I STRONGLY
SUPPORT THIS CONCEPT.
>> THANK YOU.
>> I'M HAPPY TO GO NEXT AND ADD
MY SUPPORT AS WELL.
I MET WITH Dr. YIN AND I HAD A
NICE DISCUSSION ABOUT CONCEPT
CLEARANCE AND ENTHUSIASM FOR IT
BART BECAUSE IT'S ALIGNED WITH
NIH AND NIDCR.
THERE'S REALLY GOOD ALIGNMENT
WITH FISCAL YEAR 22 TO 25 FOR
HIV AND HIV RELATED RESEARCH AND
ONE GOAL THAT IS TO BETTER
UNDERSTAND ORAL HIV ASSOCIATED
CO MORBID TEASE AND CO
INFECTIONS AND COMPUTATIONS AND
THIS IS VERY WELL RIGHT IN THE
MIDDLE OF THAT AND ALSO EVEN
MORE ALIGNED WITH THE NIDCR
STRATEGIC PLAN AND INITIATIVES
TO INTEGRATE ORAL AND GENERAL
HEALTH SO WE HEARD A LOT ABOUT
THAT JUST RECENTLY AND THIS IS
REALLY WELL PLACED IN THE MIDDLE
OF THE INITIATIVE THAT BRUCE
DONOFF JUST TOLD US ABOUT AND IT
PUTS THE MOUTH BACK IN THE BODY,
RIGHT.
THIS IS CENTRAL IN A REALLY
COMPLICATED DIAGRAM WHERE YOU
HAVE ORAL HEALTH, VIROLOGY,
EPIDEMIOLOGY, CANCER,
POTENTIALLY IMMUNOTHERAPIES AND
VACCINES, MICROBIOME RESEARCH
AND IT REALLY SITS IN THE MIDDLE
OF IS THAT DENTAL AND GENERAL
HEALTH.
IT CAN LEAD TO OPPORTUNITIES
WITH NCI TO DEVELOP
MULTI-DISCIPLINARY RESEARCH
AREAS AND SO I THINK MUCH CAN BE
BUILT FROM THIS CONCEPT.
THERE'S GREAT BUILDING ON COUPLE
OF RECENT RFAs AND THEY WERE
MORE FOCUSED AND REALLY JUST
TOUCHED ON THE FIRST BULLET
POINT HERE ON THE SLIDE THAT IS
STILL UP, STUDYING THE
EPIDEMIOLOGY AND BIOLOGY OF
PERSISTENT AND PROGRESSION AND
PEOPLE WITH HIV AND THE CONCEPT
GOES ON MUCH PAST THAT IMPACT OF
ANTI-RETRO FIE RAL THERAPY,
MECHANISMS OF HOW HIV INFECTION
CAN CHANGE AND ASPECTS AND HOW
MICROBIOME FEEDS INTO THAT AND
IMMUNO LOGIC CHANGES AND
EPIDEMIOLOGY AND MORE MECHANISMS
AND SO I THINK IT'S REALLY
EXCEEDINGLY WELL POSITIONED
STRATEGICALLY.
IN OUR DISCUSSION WE TALKED
ABOUT A COUPLE OF OTHER ISSUES
OR RECOMMENDATIONS TO MAYBE
TWEAK THIS AND ONE SO THE
RESPONSE TO THE PREVIOUS RFAs
ARE REALLY, REALLY, AS I
UNDERSTAND, MIKE OWE BIOME
FOCUSED AND WHILE MICROBIOME IS
ESSENTIAL TO THESE KINDS OF
RESEARCH QUESTIONS, WE WANTED TO
DO WHAT WE CAN TO MAKE SURE THAT
IT IS NOT -- IT SUCKS ALL THE
ATTENTION.
THERE ARE SO MANY OTHER ASPECTS
OF IMMUNOLOGY, THAT WE HOPE WE
CAN SORT OF MAKE SURE TO GET
ATTENTION AS WELL AS THE
MICROBIOME ASPECTS.
>> ONE PRIORITY WAS WE WANT TO
MAKE SURE THAT THE CONCEPT
CENTERS POPULATIONS THAT ARE
SPECIFICALLY VULNERABLE AND WE
WANT TO MAKE SURE THAT
SITUATIONS LIKE NURSING MOTHERS,
THE LGBTQIA PLUS COMMUNITY,
RECEIVE PARTICULAR ATTENTION
BECAUSE THOSE ARE THE MOST
VULNERABLE POPULATIONS AND THESE
CO INFECTIONS SITUATIONS AND
LASTLY, I'M . ENGINEER AND A
TECHNOLOGY DEVELOPER SO, YOU
KNOW, IT SORT OF WAS NATURAL FOR
ME TO WONDER HOW THIS MIGHT LEAD
TO IMMUNOTHERAPY DESIGN OR EVEN
DIAGNOSTIC DESIGN FOR CO
INFECTION SITUATIONS AND IT
SEEMS LIKE THIS SHOULD BE
POSITIONED CAREFULLY WITH
RESPECT TO IMMUNOTHERAPY
DEVELOPMENT AT NCI AND
HOPEFULLY, COLLABORATIVELY WITH
NCI SO THAT THE PATH TOWARDS
ACTUAL ADDRESSING IS CO
INFECTIONS AND CAN BE MORE
CLEARLY SORT OF MAPPED OUT.
SO BECAUSE IT'S SO STRATEGICALLY
POSITIONED WELL WITHIN IMPORTANT
INITIATIVES FOR NIH AND NIDCR.
>> I GROW WITH MY COLLEAGUES.
THIS IS A VERY TIMELY CONCEPT
AND IT WAS VERY LOGIC AND THE
BEAUTY AND THE EPIDEMIOLOGY DATA
AND NOW GUIDING THE PEOPLE GOING
TO THE MECHANISTIC STUDY WHICH
WOULD LEAD TO THE DIAGNOSTIC AND
THE THERAPEUTIC TOOLS.
SO, I HAVE NOTHING MORE TO
ADJUST SAYING THAT THIS IS
SUPPORTED AND Dr. YIN DID A
GREAT JOB TO PUT THIS CONCEPT
TOGETHER.
>> Lynn M. King: ARE THERE ANY
OTHER COMMENTS OR QUESTIONS?
IF NOT, WOULD A MEMBER OF
COUNCIL LIKE TO MAKE A MOTION
FOR RECOMMENDATIONS TO APPROVE
THIS CONCEPT?
>> SO MOVED, JACK.
>> SECOND.
WEN CHIEF.
>>.>> AYE.
>> ANY OPPOSED?
>> OK.
THANK YOU.
>> THANK YOU SO MUCH FOR YOUR
SUPPORT.
I REALLY APPRECIATE IT.
>> Lynn M. King: THANK YOU.
NEXT TWO CONCEPTS WILL BE
PRESENTED BY Dr. PREETHI
CHANDER FROM IMMUNOLOGY PROGRAM
AND THE FIRST CONCEPT WILL BE
LED BY REVIEWERS Dr. NOR AND
CHI AND GO AHEAD AND BEGIN WITH
YOUR FIRST CONCEPT, CHRONIC
INFLAMMATION OF THE ORAL CAVITY.
>> Lynn M. King: WE HAVE THE
NEXT CONCEPT READY?
CHRONIC INFLAMMATION?
>> THANK YOU.
GOOD AFTERNOON, EVERYBODY.
I AM PROGRAM OFFICER FOR THE
NIDCR BIOLOGY AND IMMUNOLOGY
PROGRAM AND I'M HERE TODAY ALONG
WITH MY COLLEAGUE Dr. MCNEIL'
THE PROGRAM OFFICER FOR THE
NIDCR ORAL MICRO AND BACTERIAL
DISEASES PROGRAM.
WE WOULD LIKE TO THANK YOU ALL
FOR THE OPPORTUNITY TO PRESENT
THIS AND SEEK COUNCIL
CONCURRENCE ON THE CONCEPT.
CHRONIC INFLAMMATION OF THE ORAL
CAVITY AN AGENT FOR ORAL MUCOSAL
DISEASE.
SO THE GOAL OF THIS CONCEPT IS
TO INVESTIGATE THE MECHANISMS
ARE CHRONIC INFLAMMATION AS THEY
RELATE TO THE ORAL ENVIRONMENT.
INCLUDING ORAL MANIFESTATIONS OF
CHRONIC SYSTEMIC DISEASES.
IT'S CLEAR FROM RESEARCH THAT
BOTH PETS OWE AGAINST IN ORAL
CAVITY PLAY A ROLE IN THE
DEVELOPMENT OF INFLAMMATION AND
THAT ALSO ALTERED THE
INFLAMMATION STATE LEADING TO
YET OTHER CONDITIONS IN THE
MOUTH.
HOWEVER, THE MECHANISMS BY WHICH
THIS HEIGHTENED STATE PRIMES THE
IMMUNE MEMORY AND THEN EFFECTS
THE ONSET AND PROGRESS OF
MUCOSAL DISEASE OF THE ORAL
CAVITY IS LESS CLEAR.
THE RESULTS OF THIS INITIATIVE
WILL DRIVE OUR UNDERSTANDING OF
THE COMPLEX PHENOMENON AND SET
THE STAGE FOR EFFORTS LEADING TO
PREVENTION OF ONSET OF CONNICK
INFLAMMATION IN CONDITIONS FOR
EXAMPLE LIKE CANCER, AUTO UM
UNITY AN MUCOSAL DISEASE AND
DISEASES OF THE ORAL CAVITY.
I WANT TO MAKE CLEAR THAT THIS
INITIATIVE IS NOT FOCUSED ON THE
DEVELOPMENT OF A TRANSITION TO
DIS PIOSIS OR DIE BIOTICS
COMMUNITIES BUT THE FOCUS IS
HERE USING CHRONIC INFLAMMATION
OF THE STARTLING POINT AND THEN
GOING ONWARDS TO THE OTHER
CONDITIONS THAT EFFECT THE ORAL
CAVITY AND TO UNDERSTAND THE
MECHANISMS.
NEXT SLIDE, PLEASE.
A COMBINATION OF WHO EXISTS IN
THE MICROBIOME, THE ENVIRONMENT,
BOTH THE HOST AND THE EXTERNAL,
AND THE HOST PLAY A ROLE IN
MAINTAINING HEALTH OF ORAL
CAVITY.
DISRUPTIONS IN ANY OF THESE MAY
LEAD TO THE INFLAMMATION STATE
WHICH IS IF UNCONTROLLED MAY BE
CHRONIC AND LEAD TO THE CONCEPT
AND PROGRESSION OF OTHER ORAL
DISEASES.
SO THIS INITIATIVE SEEKS TO
EXPAND OUR KNOWLEDGE ON THE ROLE
OF THIS EARLY CHRONIC
INFLAMMATORY STATE OF THE ORAL
CAVITY AND HOW IT RELATES TO THE
ON GOING AND PROGRESSION OF
OTHER ORAL DISEASES.
FOR EXAMPLE, IT'S NOW ACCEPTED
THAT SHIFTS IN MICROBIOME
INDUCED BY INFLAMMATION, FEVER
OVER GROWTH OF COMMON CELLS
ALTERATION AND EXPRESSION OF
FACTORS AND THESE MAY LEAD TO
CONDITIONS SUCH AS ORAL CANCER
AND LEADING TO VARIOUS OTHER
CONDITIONS.
GIVEN THIS, WE CAN SEE A NUMBER
OF OPPORTUNITIES AND SOME OF
THESE BUT NOT ALL ARE LISTED
HERE.
THE ROLE OF ORAL CHRONIC
INFLAMMATION I AM POST WORLD
CONDITIONS SUCH AS HIGHLIGHTED
BY THE PANDEMIC AND IS SEEN IN
THE CASE OF LONG COVID.
AND ALSO THE ROLE OF VARIOUS
VIRUSES LIKE EPSTEIN BAR VIRUS
AND THE PRESENCE IN THE SALIVARY
GRAND AND OTHER IMMUNE ISSUES
HAVE HIGHLIGHTED SOME OF THE
ROLES THAT EARLY INFLAMMATION
SETS THE STAGE FOR.
AND INFLAMMATION, ALTHOUGH
SUSPECTED TO PLAY A ROLE IN
PATHOGEN OF CANCER, ALSO EFFECTS
ON COMMON CELLS WHICH THEN DO
INFLUENCE OF ORAL CANCER
DEVELOPMENT AND PROGRESSION AND
MUCH NEEDS TO BE UNDERSTAND
GUIDING THE AK IS BETWEEN THE
HIKE ROW BIOME, THE IMMUNE
REACTIONS AND CANCER.
MOST MICROBIOME INTERACTIONS
WITH CHRONIC INFLAMMATION MAY
ALSO LEAD TO OTHER REACTIVITY.
ACTIVATING MECHANISMS SUCH AS
SMALL MIMIC REAND EPITOPES AND
INFECTED B CELLS THAT CAN LEN
THEY HAD TO AUTOIMMUNE RELATED
ILLNESSES.
I FOCUS ON CONTROLLING OR
PREVENTING CHRONIC INFLAMMATION
MAY LEAD TO NEW IDEAS TO PREVENT
FUNCTIONAL END POINTS RESULT
INTERESTING SUCH A STATE.
THIS INITIATIVE PROVIDES THE
OPPORTUNITY FOR A DEEPER
EXPLORATION OF THE SPECIFIC ORAL
MAN PHYSICALTATIONS OF
INFLAMMATION OF SOME CONDITIONS
LIKE ORAL LICHEN PLANUS AND
BULLOUS AND THIS IS ACROSS
DISCIPLINES TO MOVE THIS FIELD
TO OUR UNDERSTANDING OF THE ROLE
OF CHRONIC INFLAMMATION THAT IS
PLAYING AND OTHER CONDITIONS AS
THEY RELATE TO THE ORAL CAVITY.
THE OUTCOMES ARE HOPED TO LEAD
THERAPEUTIC STRATEGIES THAT THEN
ALLOW FOR ADDRESSING THIS STATE
OF THE MOUTH.
WITH THAT I WILL STOP, TAKE
QUESTIONS AND THANK THE
REVIEWERS Dr. NOR AND SHE AND
TURN IT OVER TO THEM AND I
BELIEVE Dr. NOR IS GOING
FIRST.
THANK YOU.
>> THANK YOU, Dr. CHANDER.
IT WAS A GREAT SUMMARY OF THIS
CONCEPT.
SO WE KNOW FOR A LONG TIME THAT
THE CHRONIC INFLAMMATION IN THE
ORAL CAVITY IS ASSOCIATED WITH
ORAL CONDITIONS, ORAL DISEASE
AND ORAL CANCER IS ONE OF THEM
BUT THERE ARE MANY OTHERS SO FOR
EXAMPLE, WE CAN PLAN Dr. CHA
CHANDER MENTIONED.
MANY OF THESE STUDIES HAVE BEEN
ASSOCIATION STUDIES.
IT REALLY HAVEN'T DIG VERY DEEP
IN TERMS OF MECHANISMS
UNDERLYING THIS ASSOCIATION.
WHAT I LIKE ABOUT THIS CONCEPT
HERE IS THAT IT'S REALLY
FOCUSING ON MECHANISTIC STUDIES
LOOKING HOW IT CAN CAUSE OR
PROMOTE THE PROGRESSION OF ORAL
DISEASES.
SO THIS I BELIEVE IS AN
IMPORTANT GAP OF KNOWLEDGE THAT
THIS CONCEPT IS ADDRESSING.
AND ALSO WHAT I BELIEVE IS
IMPORTANT HERE IS THE SPECIFIC
AREAS OF INTEREST, THAT ARE IN
THIS SLIDE THAT IS STILL PRESENT
HERE WITH US AND IT IS -- THIS
FOCUS ALSO ON ONLY MECHANISM BUT
A LARGER CONDITIONS THAT PREVENT
THIS PROCESS.
I CONSIDER THIS CONCEPT VERY
SIGNIFICANT IT TRANCATIONAL
STUDIES THAT CENTRAL GEEZ AND AS
SUCH I SUPPORT THIS CONCEPT.
THANK YOU.
>> YEAH.
SO, I'M TOTALLY SUPPORTIVE OF
THIS CONCEPT AS WELL AND VERY
EXCITING AND I WOULDN'T REPEAT
ALL OF THE GOOD THINGS ALREADY
TALKING ABOUT.
THE ONLY THING OF SOME OF THE
CONCERNS DURING THE DISCUSSION
IS THIS IS A TOPIC THAT WE BE
INVESTING IN FOR A LONG TIME, I
WANT TO MAKE SURE WHEN THEY
RESPOND TO THE CONCEPT THAT IT'S
NOT GOING TO BE IN A BUSINESS AS
USUAL AND IT'S STILL DOING A LOT
OF CORRELATION STUDY.
>> THE TOPIC IS BIG AND HOW DO
WE MAKE A QUANTUM LEAP INSTEAD
OF SOME SMALL INCREMENTAL
CHANGES AND THOSE ARE SOME OF
THE CONCERNS THAT WE DISCUSSED
BUT OVER ALL THIS IS A GREAT
CONCEPT AND MANY UNSOLVED
PROBLEMS SO WE'RE SUPPORTIVE OF
THIS CONCEPT.
>> THANK YOU.
>> ANY OTHER COMMENTS OR
QUESTIONS ABOUT THIS CONCEPT?
>> I HAVE ONE QUICK QUESTION.
I DON'T FULLY UNDERSTAND THE
EXCLUSION THAT I REFERRED TO OF
INFECTION-RELATED INFLAMMATION
AND MAYBE IT JUST NEEDS TO BE
WORDED A LITTLE DIFFERENT TEE?
>> GOOD POINT.
I WILL MAKE A NOTE OF THAT.
BUT I THINK THAT THE REAL POINT
WAS THAT, LIKE Dr. SHE SAID,
WE'VE HAD A LOT OF ASSOCIATED
STUD SKIS WHE'S WHERE WE'VE SEEY
CHANGE IN MICROBIOME BUT HERE WE
LOCK AT THE FUNCTIONAL EFFECTS
OF THAT THAT EFFECT WE SEEN.
WE WANT THE FOCUS TO STAY ON THE
FUNCTIONALITY AND WHAT ACTUALLY
IS THE EFFECT THAT SHIFTS THE
HOMEOSTATIC CONDITION OF THE
MOUTH TOWARDS SOME MORE DISEASE
STATE AND HOW THOSE CAN BE
PREVENTED BUT THANK YOU.
IT SOUNDS LIKE IF IT'S INFECTION
OR RELATED INFLAMMATION IT CAN'T
BE A PURSUIT HERE.
>> YEAH.
>> OK.
>> Lynn M. King: ANY OTHER
COMMENTS?
DOES ANYONE WANT -- WOULD A
MEMBER OF COUNCIL LIKE TO MAKE A
MOTION FOR RECOMMENDATION TO
APPROVE THIS CONCEPT?
>> SO MOVED.
WEN SHI.
>> SECOND.
HAL.
ALL IN FAVOR.
>> AYE.
>> ANY OPPOSED?
OK.
NOW WE CAN MOVE ON TO Dr. CHAN
DER'S SECOND CONCEPT.
THE NEXT TOPIC, GO AHEAD.
>> THANK YOU.
THANK YOU.
SO, IT'S MY PLEASURE HERE TO
PRESENT THE NEXT CONCEPT AND
THIS ONE IS TITLED DEVELOPING
SALIVARY COMPONENTS AS
THERAPEUTICS OF ORAL HEALTH.
SALIVA MAINTAIN ORAL HEALTH.
WHEN IT FLOWS REDUCED, THE OVER
ALL HEALTH ISSUES LIKE DENTAL
CARRY, ORAL MY CAN DEVELOP.
WE ALSO KNOW THAT RADIATION
INDUCED IN PATIENTS UNDERGOING
TREATMENT FOR HEAD AND NECK
CANCER ARE AUTOIMMUNE CONDITION
ARE OTHER MEDICATIONS AND JUST
THE GENERAL PROCESS OF AGING,
ARE KNOWN TO REDUCE AND IMPAIR
SALIVA PRODUCTION LEADING TO
VARIOUS HEALTH PROBLEMS IN THE
MOUTH.
BUT THERE ARE ALSO EXISTS THE
CLINICAL ISSUE WHERE THE
EXISTING SALIVA SUBSTITUTES
AVAILABLE BEFORE SIGNIFICANTLY
FROM HUMAN SALIVA AND OUR
CLINICAL ELECTRICAL CONNECTIVITY
AND THESE ARE FOR IN ADEQUATE OR
SHOT DOWN RELIEF IN PATIENTS.
OVER THE YEARS WE HAVE EX TO
APPRECIATE THE FACT THAT EACH
SALIVA COMPONENT PLAYS AN
ESSENTIAL ROLE IN LOSS OF WHICH
WILL COMPROMISE HEALTH AND
REPLENISHING THESE COMPONENTS IS
ESSENTIAL FOR PROCESSES SOME OF
WHICH ARE, MANY OF WHICH ARE
IMPORTANT TO ENHANCING WOUND
HEALING, AND INCREASING BY OWE
MATERIALS SURVIVAL, AND
REPLENISHING (INAUDIBLE).
THE GOAL OF THIS INITIATIVE IS
THUS TO ENCOURAGE INTER
DISCIPLINARY RESEARCH THAT
HARNESSES THE FUNCTIONAL
COMPONENTS OF SALIVA TOWARDS
BIOLOGIC THERAPIES AND THIS WILL
ENCOURAGE STUDIES FOR THE
CONSTITUENTS AND IT MOVE THEM
TOWARDS RECEIPT TWITH A FOCUS OD
RESILIENCE OF THE ORAL CAVITY SO
THE OUTCOMES ARE EXPECTED TO
FACILITATE THE DEVELOPMENT OF
INDIVIDUALS EFFECTIVE SORROW GOT
SALIVA FOR CLINICAL APPLICATIONS
PROMOTE AND RESTORE ORAL HEALTH.
LIKE THE OTHER ONE, I WOULD LIKE
TO HIGHLIGHT THAT THIS
INITIATIVE IS NOT FOCUSED ON
DEVELOPMENT OF BIOMARKERS OR
DIAGNOSTIC BUT DEVELOPMENT OF
BIOLOGIC THERAPIES, NOT THE
ORGANIC COMPONENTS AND OR EVEN
PROBIOTICS BUT REALLY THE
BIOLOGIC COMPONENTS THAT MAKE UP
SALIVA AND HAVE A FUNCTIONAL
CONSEQUENCE AND THUS CAN ARE
RESTORED TO PROMOTE HEALTH OF
THE MOUTH.
SO, THE SMALL FRACTION OF
SALIVA, WHICH IS THE ONE PERSON
NON COMPONENTS CONTAIN GLYCANS
THAT ENABLE SALIVA TO PLAY A
ROLE IN DEFENSE AGAINST
INFECTIONS AND MAINTENANCE OF
ORAL MICROBIOME AND WOUND
HEALING AND MAINTENANCE OF
HEALTH.
SO THE EARLY STUDIES THAT WE
HAVE SEEN SO FAR, HAVE BEEN ABLE
TO DELINEATE SOME OF THESE
FUNCTIONS BUT WE'RE AT A POINT
WHERE WE NEED TO HARNESS THIS
KNOWLEDGE TO MOVE TO ITS
THERAPEUTIC DEVELOPMENT OF THESE
COMPONENTS FOR APPLICATIONS IN
ORAL HEALTH.
SOME OF THE DEVELOPMENTS THAT
COVID AND THE CREATIVITY OF OUR
INVESTIGATORS HAVE LED TO CAN BE
SEEN AND THE INTEGRATION OF
SALIVA AND BLOOD PLASMA
COMPONENTS AND ENABLE LINKINGS
SALIVA PROTEINS TO THEIR SOURCE
AND IDENTIFICATION OF SALIVARY
GLANDS-SPECIFIC GENES,
UNCOVERING GENE REPERTOIRE
LINKING THE EXAMINATION OF THE
SPECIFIC SALIVARY COMPONENT IN A
SPECIFIC CONTEXT AND THE HUMAN
ARE AVAILABLE TO THE COMMUNITY
AS THE HUMAN SALIVARY PRO TEEOME
IT INCLUDES SEEKEL CELL
SEQUENCING OF THE CRANIOFACIAL
BIOLOGICAL WORK.
IT'S SPECIFICALLY FOR COVID
RELATED STUDIES OF THE ORAL
CAVITY.
WE CAN SEE THE AREAS OF INTEREST
THAT THESE DEVELOPMENT.
WITH THAT EIGHTH I WILL TURN ITE
REVIEWERS.
DID SHI WILL GO FIRST.
>> SO WE'RE SUPER EXCITED ABOUT
THIS CONCEPT AND THIS IS REALLY
I THINK IS A QUANTUM LEAP IN
HIGHLY INNOVATIVE WITH NIDCR
HAVE INVESTED SO MUCH MONEY ON
DEVELOPING THE SALIVARY
PROTEASOME.
>> Omar: AND THIS IS THE TIME
AND DISCOVERIES INTO A
AND WEEXPECT TO HAVE A GREAT OUE
AND WE'RE EXCITED ABOUT THIS AND
DURING THE DISCUSSION THE ONLY
THING WE WANT TO MAKE SURE IS
LET'S NOT OVERLAP WITH THE
TRADITIONAL SALIVARY FUNCTION
WHICH IS A LOOK AT AND IT'S
INORGANIC COMPONENTS OR THE
PROBIOTICS AND WE WANT THAT IS
THE FOCUS ON THE ORGANIC
COMPONENT OF THOSE SALIVARY
COMPONENTS THAT WE'VE
DISCOVERED.
GREAT CONCEPT.
VERY EXCITED ABOUT IT.
>> HE AGREE.
I'M VERY EXCITE BESIDE THIS
CONCEPT AND I THINK THAT AGAIN
Dr. CHANDER DID A WONDERFUL
JOB PUTTING IT TOGETHER AND VERY
TIMELY AND I MEAN, WE KNOW FOR A
VERY LONG TIME THAT SALIVA IS
VERY IMPORTANT IN MANY
BIOLOGICAL PROCESSES AND ONE OF
THEM IS ONE HEALING.
REALLY UNDERSTANDING WHAT ARE
THE BIO MOLECULES IN SALIVA THAT
DO THE JOB?
IT WILL BE CRITICAL SO IF
FUNCTION OF STUDIES ARE CRITICAL
AND THEY MAY LEAD TO NEW
PRODUCTS AND FROM MID
INDICATIONS USE AND --
>> THANK YOU.
>> YOU CAN THINK BIGGER BECAUSE
WHEN I SAW THE TITLE AS
THERAPEUTIC FOR ORAL HEALTH, IT
OCCURS TO ME AS MANY OF THESE
DISCOVERIES MAY APPLY TO OTHER
AREAS OF THE BODY, PARTICULARLY
WHEN YOU THINK ABOUT WORKING ON
IT THERE'S A TREMENDOUS NEED FOR
THERAPEUTICS ALL OVER THE BODY.
AND IT COULD BE WE KNOW THEY
FEEL WELL UNDER NORMAL
CIRCUMSTANCES AND IT COULD BE
THAT THERE'S SOME VERY IMPORTANT
DISCOVERY THERE THAT CAN BEING
TRANSLATED INTO DIABETIC ULCERS
OR SERIOUS DISEASES SO I GUESS
WE'RE CONNECTING HEAD BACK TO
THE BODY AGAIN.
SO JUST A SUGGESTION.
THANK YOU.
>> THANK YOU.
>> Lynn M. King: ANY OTHER
COMMENTS?
WOULD A MEMBER OF COUNCIL LIKE
TO MAKE A MOTION FOR
RECOMMENDATIONS TO APPROVE THIS
CONCEPT?
>> SO MOVED.
>> WEN SHI SECOND.
>> ALL IN FAVOR.
AYE.
>> ANY OPPOSED?
>> Lynn M. King: OK.
THE FINAL CONCEPT TODAY WILL BE
PRESENTED BY Dr. LU WANG CHIEF
OF THE TRANSLATION ALGAE NOMICS
BRANCH.
AND SHE WILL PRESENT THIS
CONCEPT.
>> THANK YOU, LYNN.
GOOD AFTERNOON COUNCIL.
TODAY I SEEK YOUR CONCURRENCE ON
THE PROGRAM INITIATIVE CONCEPT
ENTITLED APPLY DATA SIGNS IN
TRANSLATIONAL DIDN'TAL ORAL AND
CRANIOFACIAL RESEARCH.
I WOULD LIKE TO THANKS Dr.
AXEL VISEL ON THE UPDATE ON THE
COUNCIL DATA SIGNS STRATEGY
WORKING GROUP WHICH PROVIDES
TIMELY, COMPREHENSIVE AND
EXCITING CONTEXT FOR THIS
CONCEPT.
SO, THIS INITIATIVE IS AIMED TO
PROMOTE EFFORTS AND THE NEXT
SLIDE, PLEASE.
THIS INITIATIVE IS AIMED TO
PROMOTE EFFORTS THAT WILL USE
AND FACILITATE THE USE OF DATA
SIZE APPROACHES IN DENTAL, ORAL
AND CRANIOFACIAL RESEARCH OR DOC
RESEARCH THAT FANS THE FULL
SPECTRUM OF BASIC, PRE CLINICAL,
CLINICAL, CLINICAL
IMPLEMENTATION AND TOPIC HEATH.
THE FAR-REACHING APPROACH WILL
BE TAKEN TO DRAW GRANT
APPLICATIONS FROM DIVERSE
TALENTS WHO ARE CURRENTLY ACTIVE
EITHER IN THE AREA OF DOC OR
OTHER SITES AND DISEASES OR
DISEASE AGNOSTIC DATA SIGNS.
THE BROAD RANGE OF SUPPORTS WILL
BE PROVIDED INCLUDING FOR
RESEARCH, RESEARCH AND CAREER
DEVELOPMENT, PRODUCT
DEVELOPMENT, AND CONFERENCES.
OVER ALL, THE INITIATIVE WILL
PROMOTE THE DEVELOPMENT,
DISSEMINATION, AND USE OF THE
STATE OF THE ART DATA SCIENCE
RESOURCES AND TOOLS IN DOC
RESEARCH WITH MORE FOCUS ON
MAXIMIZING DATA REUSE TO DEVELOP
AND DELIVER EVIDENCE-BASED
CLINICAL APPLICATIONS.
THIS INITIATIVE IS INSPIRED BY
NIDCR'S CURRENT STRATEGIC PLAN
AND THE DAM ON THE RIGHT IS
INTENDED TO DEPICT ALL FIVE
STRATEGIC PRIORITIES AND
OFFER OPTIMIZED REUSABILITY,
DATA ANALYTICS, AND STATE OF THE
ART OF DATA SCIENCE METHODS AND
RESOURCES AND TO ALLOW
INVESTIGATORS AND CLINICIANS TO
CLASSIFY DATA TYPES SO, SORT
PATTERNS AND UNCOVER LINEAGES
AND IN SO DOING, ADDRESS
FOUNDATIONAL TRANSLATIONAL AND
CLINICAL RESEARCH QUESTIONS.
AND AS Dr. VISEL PRESENTED,
FACING THESE CHALLENGES AND
OPPORTUNITIES, THE COUNCIL DATA
SCIENCE STRATEGY WORKING GROUP
HAS BEEN CHARGED TO MAKE
RECOMMENDATIONS ON DATA SIGNS
STRATEGIES.
FOLLOWING THE RECOMMENDATIONS,
MORE SPECIFICALLY FOCUSED
FOUNDING AND RESEARCH
OPPORTUNITIES ARE ANTICIPATED
WITHIN THE NEXT YEARS DEFINITELY
IN THE FORESEEABLE YEARS.
THIS INITIATIVE WILL START NOW
TO INVESTIGATORS WHO WILL BE
MORE PRIME TO ACT ON THOSE
OPPORTUNITIES.
TO EXPEDITE THE POWER OF DATA
SCIENCE IN DEVELOPING AND
DELIVERING HEATH SOLUTIONS.
NEXT SLIDE, PLEASE.
SO EXAMPLES OF RESEARCH INTEREST
UNDER THIS INITIATIVE ARE AS
FOLLOWS -- MAXIMIZE THE REUSE OF
RESEARCH AND CLINICAL DATA AND
ENABLE DATA DRIVEN RESEARCH BY
MAKING BOTH RETROSPECTIVE AND
PROSPECTIVE DATA FAIR AND
MACHINE LEARNING READY.
AND BY DEVELOPING DATA
ANALYTICS, COMMON DATA ELEMENTS
AND SYSTEMS AND AS WELL AS THE
NATURAL LANGUAGE PROCESSING
CAPABILITIES THAT ARE APPLICABLE
SUCH AS ELECTRONIC HEALTH
RECORDS AND PUBLICATIONS.
TO IMPROVE DIAGNOSTIC TEST
EFFICACY AND TREATMENT PLANNING
AND EXAMPLE MAY BE MERGING RNA
SEQUENCE BASED DIAGNOSTICS INTO
DIGITAL PATHOLOGY BASED CLINICAL
DIAGNOSTICS PIPELINE.
AND ANOTHER EXAMPLE SPEAKS TO
THE INTEGRATION OF ELECTRONIC
DENTAL AND MEDICAL RECORDS TO
PROMOTE COMPREHENSIVE AND
DATA-DRIVEN RESEARCH IN ORDER TO
FACILITATE BETTER INFORMED CARE
AND TREATMENT PLANNING.
ALSO, THERE'S OPPORTUNITIES IN
DEVELOPING DEEP PHENOTYPING DATA
CURATION AND DATA ANALYSIS WEB
INTERFACING TO SUPPORT
DECISION-MAKING FOR INSTANCE,
INTERFACE MAY HAVE IMAGING AND
MONDAY AT THE OMICS DATA
CURATION AND ANALYSIS FUNCTIONS
FOR CLINICIANS TO USE AND THAT
IS TO BE INFORMED FOR TREATMENT
PLANNING.
LAST BUT NOT LEAST,
OPPORTUNITIES THERE'S A LOT OF
OPPORTUNITIES IN BROADLY IN
RECRUITING DATA AND THEN
CURATING AND ANALYZING MULTI
DIMENSIONAL DATA INCLUDING
BIOLOGICAL, BEHAVIORAL,
ENVIRONMENTAL, SOCIAL, AND
HEALTH DATA THAT ARE OBTAINED
FROM MULTIPLE POPULATIONS AND
AGE GROUPS AND HEALTH
DISPARITIES AND PREVENTION AND
ORAL HEALTH AND CONDITIONS
INCLUDING CHILDHOOD DENTAL CARE.
AND SO THAT WAS THE LAST SLIDE.
WITH THAT, I THANK YOU FOR YOUR
ATTENTION AND I'M READY TO
ADDRESS QUESTIONS.
>> IT WILL COME AS NO SURPRISE
THAT WE'RE ALL VERY ENTHUSIASTIC
ABOUT THIS CONCEPT AND IT FITS
NICELY WITH THE PRESENTATION
THAT AXEL GAVE ABOUT THE WORKING
GROUP.
IT'S OBVIOUS THAT THIS IS SORT
OF THE NEXT FRONTIER IN SOME
RESPECT AND IN TERMS OF BEING
ABLE TO USE THESE MASSIVE DATASO
THE REAL WORLD AND UNDERSTAND
MORE ABOUT WHAT IS GOING ON.
I DID NOT HAVE ANY CONCERNS
ABOUT ANYTHING IN THE CONCEPT.
LOU AND I SPOKE A LITTLE BIT
ABOUT JUST TRYING TO MAKE SURE
THAT NOT ONLY IS THE MOUTH
ATTACHED TO THE BODY BUT WE
THINK ABOUT THE BODY AS BEING
WHOLE PEOPLE AND SO EMBEDDED IN
SOCIAL AND CULTURAL CONTEXT
BECAUSE I THINK THAT'S A PIECE
OF WHAT WE'RE GOING TO BE ABLE
TO GET BY MOVING IN THIS DATA
SCIENCE WAY.
SO WE WERE SUPER ENTHUSIASTIC
AND THAT SUMS UP MY THOUGHTS.
>> THANK YOU, AMY.
I DON'T HAVE TOO MUCH TO ADD.
AS PART OF THE WORKING GROUP.
I'M VERY EXCITED ABOUT THIS
CONCEPT AND I JUST HAD ANY
PRESENTATION TODAY HOW DATA
SCIENCE WILL HAVE MAJOR IMPACTS
ON ALL AREAS OF NIDCR'S
ACTIVITIES IN THE FUTURE.
THAT WE SAW FROM THIS CONCEPT
DOWN THE ROAD.
THE OTHER PART THAT I LIKE ABOUT
THIS CONCEPT IS IT'S VERY BROAD
AND AS I DESCRIBED DATA SCIENCE
IS MORE THAN MACHINE LEARNING
ARTIFICIAL INTELLIGENCE AND THIS
CONCEPT TAKES A HOLISTIC
APPROACH AND COVERS ALL OF THESE
OTHER IMPORTANT COMPLIMENTARY
AREAS THAT I DESCRIBED AND I
EXPECTED THEY HAVE TO BE
PARTICULARLY IMPACTFUL IN
ADVANCING THE NIDCR MOTION.
SO, IN SUMMARY, I'M EXCITED AND
ENTHUSIASTIC AND FULLY
SUPPORTIVE OF THIS CONCEPT.
>> Lynn M. King: ANY QUESTIONS
OR COMMENTS?
>> IT'S TERRY.
I'M REALLY EXCITED ABOUT THE
INTEGRATION OF MEDICAL RECORDS
AND FROM A CLINICIAN STANDPOINT
BECAUSE AS IT SAYS, FACILITATE
AND TREATMENT AND THAT IS SO
VALUABLE.
>> ANY OTHER COMMENTS.
>> ANY OTHER COMMENTS?
WOULD A MEMBER OF COUNCIL LIKE
TO MAKE A MOTION FOR
RECOMMENDATIONS TO APPROVE THIS
CONCEPT.
>> I MAKE A RECOMMENDATION.
>> ANYONE LIKE TO SECOND?
>> I'LL SECOND IT.
>> I'LL IN FAVOR?
>> AYE.
>> ANYONE OPPOSED?
OK.
SO WE REACHED THE END OF THIS
SESSION.
AND EYE LIKE TO THANK THE DOCTOR
FOR PARTICIPATING AND CONTRIBUTE
TO GO THE DISCUSSIONS.
AND I WOULD LIKE TO REMIND THE
LISTENING TO THE AUDIENCE TO YOU
MAY SUBMIT COMMENTS OR QUESTIONS
ABOUT THE OPEN SESSION TO THE
MAILBOX WHICH WE'LL PRESENT AT
END OF THIS AND I TURNOVER TO
Dr. RE MARINA VON STAKELBERG Dr.
D'SOUZA.
>> THANK YOU, I KNOW HOW HARD
YOU WORK TO MAKE THESE
PRESENTATIONS SEAMLESS SO THANK
YOU.
YOU ALL DID VERY WELL.
AND JUST TO LET EVERYONE KNOW
THAT THAT WHOLE PROCESS OF
CONCEPT CLEARANCE IS A REALLY
MULTI-DIRECTIONAL STREAM OF
INPUT THAT WE SEEK FROM YOU ALL.
WE PICK UP THE MEETINGS FROM
PUBLICATIONS AND SO KEEP THAT
FLOWING BECAUSE THAT'S HOW IDEAS
GEL AND YOU CAN SEE THERE'S SO
MUCH TO DO AND SO MUCH WE CAN
LOOK FORWARD TO.
SO THANK YOU FOR THAT AFTERNOON.
I'M LIKELY TO WANT TO CHANGE --
I WAS JUST TELLING LYNN YAM THE
DIRECTORS POWER BECAUSE WE
BASKETBALBABBLEI. I'M GOING TO H
THE EXECUTIVE TEAM SO WE MOVE
THROUGH PRESENTATION AND HAVE A
LITTLE BIT OF CHANGE AND I'M
GOING TO TRY A FEW APPROACH
THAT'S WOULD ALLOW US TO BE
INTERACTIVE AND ENGAGE
THROUGHOUT THESE LONG SESSIONS.
ALWAYS LOOKING FOR SUGGESTIONS
FROM YOU.
WAYS TO IMPROVE OUR
COMMUNICATIONS AND TO TRY TO
MAKE IT MORE INTERACTIVE IN A
ZOOM THAT ENGAGES PARTICIPANTS
NOT IN THIS GROUP OF INTERN ALS.
WE HOPE TO EXPAND SO WE CAN GET
CHAT COMMENTS GOING.
WE'RE GOING TO WORK TOWARDS THAT
AND OF COURSE THE IN-PERSON
SESSION THAT HOPEFULLY WE'LL BE
POSSIBLE FOR MAY HAVE NEXT YEAR.
THANK YOU VERY MUCH FOR SIGNING
UP, STICKING WITH IT AND
ENJOYING.
I HOPE ENJOYING HEARING ABOUT
WHERE NIDCR IS MOVING INTO THIS
NEW ERA OF SUCCESS.
THANK YOU.