1 00:00:05,360 --> 00:00:10,680 >>WELCOME TO THE 230th 2 00:00:10,680 --> 00:00:13,320 MEETING OF THE NATIONAL ADVISORY 3 00:00:13,320 --> 00:00:15,200 DENTAL AND CRANIOFACIAL RESEARCH 4 00:00:15,200 --> 00:00:16,040 COUNCIL. 5 00:00:16,040 --> 00:00:18,240 I'M LYNN KING, DIRECTOR OF THE 6 00:00:18,240 --> 00:00:20,440 DIVISION OF EXTRAMURAL ACTIVITY, 7 00:00:20,440 --> 00:00:22,520 EXECUTIVE SECRETARY OF THE NIDCR 8 00:00:22,520 --> 00:00:24,800 COUNCIL, I'M GOING TO BEGIN WITH 9 00:00:24,800 --> 00:00:26,680 A FEW INFORMATIONAL PROCEDURE 10 00:00:26,680 --> 00:00:27,440 ITEMS. 11 00:00:27,440 --> 00:00:29,640 TODAY'S PROCEEDINGS ARE BEING 12 00:00:29,640 --> 00:00:31,400 CONDUCTED VIA ZOOM WITH 13 00:00:31,400 --> 00:00:32,040 ACCOMPANYING VIDEOCAST FOR 14 00:00:32,040 --> 00:00:34,560 VIEWING BY THE GENERAL PUBLIC. 15 00:00:34,560 --> 00:00:36,440 WE'LL NOT BE TAKING QUESTIONS OR 16 00:00:36,440 --> 00:00:39,200 COMMENTS FROM THE PUBLIC DURING 17 00:00:39,200 --> 00:00:41,120 THE WEBCAST BUT WELCOME 18 00:00:41,120 --> 00:00:43,040 QUESTIONS OR COMMENTS UNTIL JUNE 19 00:00:43,040 --> 00:00:45,960 1, SUBMITTED TO A SPECIAL NIDCR 20 00:00:45,960 --> 00:00:47,160 E-MAIL BOX THAT WILL BE 21 00:00:47,160 --> 00:00:49,240 DISPLAYED AT THE END OF THIS 22 00:00:49,240 --> 00:00:49,480 SESSION. 23 00:00:49,480 --> 00:00:51,200 WE ASK THE COUNCIL MEMBERS AND 24 00:00:51,200 --> 00:00:54,040 STAFF TO PLEASE MAKE SURE THAT 25 00:00:54,040 --> 00:00:56,240 YOUR MICROPHONES ARE SET ON MUTE 26 00:00:56,240 --> 00:00:58,200 AND YOUR VIDEO CAMERAS ARE OFF 27 00:00:58,200 --> 00:00:59,520 UNLESS YOU'RE SPEAKING. 28 00:00:59,520 --> 00:01:01,600 WHEN SPEAKING AT ANY TIME, 29 00:01:01,600 --> 00:01:02,360 PLEASE IDENTIFY YOURSELF SO WE 30 00:01:02,360 --> 00:01:05,000 KNOW WHO IT IS WHO IS SPEAKING 31 00:01:05,000 --> 00:01:08,920 AND TO ENSURE ACCURACY OF OUR 32 00:01:08,920 --> 00:01:09,160 RECORDS. 33 00:01:09,160 --> 00:01:10,880 IF ANYONE PARTICIPATING IN THE 34 00:01:10,880 --> 00:01:13,040 ZOOM VIDEOCAST NEEDS TECHNICAL I 35 00:01:13,040 --> 00:01:17,480 A SIS TANS, THE NIDCR I.T. TEAM 36 00:01:17,480 --> 00:01:19,320 TIM AND KEVIN WILL BE AVAILABLE 37 00:01:19,320 --> 00:01:20,760 TO ASSIST YOU. 38 00:01:20,760 --> 00:01:22,720 THEIR CONTACT INFORMATION IS IN 39 00:01:22,720 --> 00:01:24,400 THE CHAT BOX. 40 00:01:24,400 --> 00:01:31,360 NOW WE'LL HEAR FROM THE DIRECTOR 41 00:01:31,360 --> 00:01:36,840 OF NIDCR, DR. RENA D'SOUZA. 42 00:01:36,840 --> 00:01:38,000 >> GOOD MORNING, I'M HAPPY TO 43 00:01:38,000 --> 00:01:41,000 SEE YOU PARTICIPATE IN THE 44 00:01:41,000 --> 00:01:42,600 230th COUNCIL, SEEMS TO GET 45 00:01:42,600 --> 00:01:44,040 BETTER FOR ME OVER TIME. 46 00:01:44,040 --> 00:01:47,040 I WANT TO START OFF BY SAYING 47 00:01:47,040 --> 00:01:49,720 WHAT WE EXPERIENCED IN THE PAST 48 00:01:49,720 --> 00:01:51,920 WEEK UNLEASHING OF ANOTHER 49 00:01:51,920 --> 00:01:53,880 HORRIFIC AND RACIALLY MOTIVATED 50 00:01:53,880 --> 00:01:55,520 SHOOTING TO INNOCENT CIVILIANS 51 00:01:55,520 --> 00:01:56,760 IN BUFFALO, NEW YORK, JENNIFER 52 00:01:56,760 --> 00:02:02,000 AND I JUST SENT OUT A MESSAGE 53 00:02:02,000 --> 00:02:04,640 THAT I WANT TO READ. 54 00:02:04,640 --> 00:02:07,040 WE REALLY WROTE TO EXTEND THE 55 00:02:07,040 --> 00:02:08,160 SUPPORT AND COMFORT TO OUR 56 00:02:08,160 --> 00:02:09,360 AFRICAN AMERICAN COLLEAGUES FOR 57 00:02:09,360 --> 00:02:12,400 WHOM THE BURDEN OF SOCIETAL 58 00:02:12,400 --> 00:02:14,360 INJUSTICE REMAINS ONEROUS AND 59 00:02:14,360 --> 00:02:16,120 BECOMES HEAVIER WITH EVERY 60 00:02:16,120 --> 00:02:17,840 ADDITIONAL INCIDENT. 61 00:02:17,840 --> 00:02:19,440 KNOW THAT NIDCR IS FIERCELY 62 00:02:19,440 --> 00:02:24,440 COMMITTED TO A COMMUNITY THAT 63 00:02:24,440 --> 00:02:26,040 EMBRACES ALL, IRRESPECTIVE OF 64 00:02:26,040 --> 00:02:31,440 RACE, RELIGION, GENDER IDENTITY. 65 00:02:31,440 --> 00:02:36,160 WE'RINTENTIONAL TO IMPROVING, 66 00:02:36,160 --> 00:02:38,000 BELONGING IS OUR RESPONSE TO 67 00:02:38,000 --> 00:02:40,760 COMBAT SYSTEMIC INJUSTICE THAT 68 00:02:40,760 --> 00:02:42,560 IS MANIFESTED ITSELF IN OUR 69 00:02:42,560 --> 00:02:43,360 COMMUNITY OVER TIME. 70 00:02:43,360 --> 00:02:44,920 PLEASE JOIN US IN KNOWING THAT 71 00:02:44,920 --> 00:02:47,000 YOU DO NOT STAND ALONE AS WE 72 00:02:47,000 --> 00:02:48,240 WORK TOWARDS THE REALIZE AGO 73 00:02:48,240 --> 00:02:52,520 THAT AFTER ALL THERE IS ONLY ONE 74 00:02:52,520 --> 00:02:54,880 RACE, THE HUMAN RACE. 75 00:02:54,880 --> 00:02:57,520 WE ALSO WEAR AT NIDCR AND I'M 76 00:02:57,520 --> 00:02:59,720 SURE IN YOUR VARIOUS 77 00:02:59,720 --> 00:03:00,920 INSTITUTIONS, STAFF THAT 78 00:03:00,920 --> 00:03:02,040 SUFFERED PERSONAL LOSSES, MAY 79 00:03:02,040 --> 00:03:05,920 EACH OF YOU FIND SOLACE AS YOU 80 00:03:05,920 --> 00:03:07,080 GRIEVE THIS LOSS. 81 00:03:07,080 --> 00:03:11,200 WE'RE AWARE OF THE SURGE OF 82 00:03:11,200 --> 00:03:13,160 MANY PEOPLE NOT FEELING QUITE 83 00:03:13,160 --> 00:03:15,280 WELL, TAKE CARE AND STAY HOME 84 00:03:15,280 --> 00:03:18,320 AND BE WATCHFUL. 85 00:03:18,320 --> 00:03:20,080 I END THAT SYMPATHY AND RESOLVE 86 00:03:20,080 --> 00:03:21,600 TOWARDS BUILDING A BETTER 87 00:03:21,600 --> 00:03:21,880 TOMORROW. 88 00:03:21,880 --> 00:03:24,880 THAT'S MY OPENING STATEMENT TO 89 00:03:24,880 --> 00:03:29,240 YOU, COUNCIL MEMBERS, AND THOSE 90 00:03:29,240 --> 00:03:29,760 ATTENDING. 91 00:03:29,760 --> 00:03:33,120 ON A SAD MIXED FEELING NOTE I 92 00:03:33,120 --> 00:03:35,520 WANT TO SAY FAREWELL AND THANK 93 00:03:35,520 --> 00:03:37,080 YOU TO FOUR OUTSTANDING COUNCIL 94 00:03:37,080 --> 00:03:39,120 MEMBERS WHO DEDICATED THEIR TIME 95 00:03:39,120 --> 00:03:41,720 AND EFFORTS TO MOVING NIDCR 96 00:03:41,720 --> 00:03:46,240 FORWARD IN YOUR TERM ON COUNCIL, 97 00:03:46,240 --> 00:03:48,120 KATHY, DAVID, CLARK AND JOEL, 98 00:03:48,120 --> 00:03:49,760 I'LL MESS YOU BECAUSE YOU 99 00:03:49,760 --> 00:03:51,600 WELCOMED ME SO WARMLY AS I 100 00:03:51,600 --> 00:03:52,920 STARTED MY FIRST JOURNEY HERE 101 00:03:52,920 --> 00:03:53,680 WITH YOU. 102 00:03:53,680 --> 00:03:55,560 PLEASE DO STAY IN TOUCH. 103 00:03:55,560 --> 00:03:59,040 WE INTEND TO ENGAGE YOU AS WE 104 00:03:59,040 --> 00:04:01,800 ADVANCE NIDCR INTO A NEW ERA OF 105 00:04:01,800 --> 00:04:02,200 SUCCESS. 106 00:04:02,200 --> 00:04:04,000 WE HAVE NEWCOMERS ON BOARD THAT 107 00:04:04,000 --> 00:04:05,280 WOULD BE INTRODUCED AT NEXT 108 00:04:05,280 --> 00:04:06,960 COUNCIL WHICH WOULD BE IN 109 00:04:06,960 --> 00:04:09,720 SEPTEMBER. 110 00:04:09,720 --> 00:04:12,520 LIKELY TO BE VIRTUAL. 111 00:04:12,520 --> 00:04:14,480 THRILLED TO WELCOME A SENIOR 112 00:04:14,480 --> 00:04:16,960 MEMBER ON THE STAFF HEADING 113 00:04:16,960 --> 00:04:18,840 RESEARCH TRAINING AND CAREER 114 00:04:18,840 --> 00:04:20,560 DEVELOPMENT BRANCH, WHO COMES 115 00:04:20,560 --> 00:04:31,080 WITH A WEALTH OF EXPERIENCE IN 116 00:04:33,320 --> 00:04:39,280 NIGMS, WHO FORGED AVENUES OF 117 00:04:39,280 --> 00:04:39,920 DIVERSE PIPELINES, SO ANISSA, 118 00:04:39,920 --> 00:04:40,920 WELCOME ON BOARD. 119 00:04:40,920 --> 00:04:43,360 WE LOOK FORWARD TO YOUR 120 00:04:43,360 --> 00:04:44,440 LEADERSHIP IN THAT BRANCH. 121 00:04:44,440 --> 00:04:46,520 YOU TAKE OVER FOR LYNN KING WHO 122 00:04:46,520 --> 00:04:48,160 LEFT A GREAT LEGACY AND YOU HAVE 123 00:04:48,160 --> 00:04:51,360 GREAT STAFF IN LESLIE FRIEDEN 124 00:04:51,360 --> 00:04:53,600 WHO WILL ASSIST YOU TO ACHIEVE 125 00:04:53,600 --> 00:04:57,000 ALL THAT YOU DREAM ABOUT FOR 126 00:04:57,000 --> 00:04:58,400 NIDCR AND FOR US. 127 00:04:58,400 --> 00:05:00,760 THANK YOU AND WELCOME. 128 00:05:00,760 --> 00:05:03,520 NOW, IT'S A VERY SPECIAL 129 00:05:03,520 --> 00:05:05,800 MEETING, SPECIAL IN MANY WAYS. 130 00:05:05,800 --> 00:05:07,640 WE HAVE A GREAT PANEL OF 131 00:05:07,640 --> 00:05:09,920 SPEAKERS WHO WILL SHARE THEIR 132 00:05:09,920 --> 00:05:12,240 EXPERIENCES AND EXPERTISE WITH 133 00:05:12,240 --> 00:05:13,440 US. 134 00:05:13,440 --> 00:05:15,280 TOP ON THAT LIST IS LARRY TABAK. 135 00:05:15,280 --> 00:05:18,040 I WAS THINKING OF THE TIME OF 136 00:05:18,040 --> 00:05:20,520 TRANSITION FOR OUR SOCIETY, 137 00:05:20,520 --> 00:05:23,520 CULTURE, THE COUNTRY, THE WORLD, 138 00:05:23,520 --> 00:05:29,280 AND NIH WE'RE NOT EXCLUDED FROM 139 00:05:29,280 --> 00:05:31,400 THIS TIME OF CHANGE, SOUL 140 00:05:31,400 --> 00:05:33,560 SEARCHING AND REFORM, NO BETTER 141 00:05:33,560 --> 00:05:34,880 PERSON THAN LARRY WHO WOULD GIVE 142 00:05:34,880 --> 00:05:38,600 A TRUE SENSE FOR NIH IS TODAY 143 00:05:38,600 --> 00:05:42,840 AND WHERE IT'S HEADING IN THE 144 00:05:42,840 --> 00:05:44,960 FUTURE. 145 00:05:44,960 --> 00:05:47,040 FOR ME HE'S BEEN INDISPENSABLE 146 00:05:47,040 --> 00:05:49,400 TO MY CAREER AND LIFE. 147 00:05:49,400 --> 00:05:51,320 WONDERFUL FOR OUR PROFESSION, NO 148 00:05:51,320 --> 00:05:52,520 DOUBT ABOUT THAT, ONE OF A KIND 149 00:05:52,520 --> 00:06:02,880 IN THE WAY HE ACTUALLY CHANNELS 150 00:06:02,880 --> 00:06:04,840 HIS SON'S MUSICAL TALENT, HE 151 00:06:04,840 --> 00:06:07,600 SAYS HE HAS NONE, IN A 152 00:06:07,600 --> 00:06:10,160 SELF-DEPRECATING WAY MAKES US 153 00:06:10,160 --> 00:06:13,400 LAUGH, A ONE OF A FIND SCIENTIST 154 00:06:13,400 --> 00:06:15,640 IN BIOCHEMISTRY, FUNCTION, ALL 155 00:06:15,640 --> 00:06:19,160 WHICH LAID THE FRAMEWORK FOR 156 00:06:19,160 --> 00:06:19,920 DIAGNOSTICS. 157 00:06:19,920 --> 00:06:20,920 LARRY HAS DISTINGUISHED HIMSELF 158 00:06:20,920 --> 00:06:23,440 AS A LEADER ON OUR CAMPUS AND IN 159 00:06:23,440 --> 00:06:27,120 MORE WAYS THAN I CAN POSSIBLY 160 00:06:27,120 --> 00:06:27,360 DESCRIBE. 161 00:06:27,360 --> 00:06:29,280 HE HAS KEPT US SAFE AND STABLE 162 00:06:29,280 --> 00:06:31,120 THROUGH THIS TIME, THE TIME 163 00:06:31,120 --> 00:06:32,760 PRECEDING THE PANDEMIC, DURING 164 00:06:32,760 --> 00:06:34,960 THE PANDEMIC, AND SURELY MAKING 165 00:06:34,960 --> 00:06:36,720 SURE THAT WE ARE WELL POSITIONED 166 00:06:36,720 --> 00:06:39,000 FOR THE FUTURE. 167 00:06:39,000 --> 00:06:42,520 WE OWE HIM AN IMMEASURABLE 168 00:06:42,520 --> 00:06:43,600 AMOUNT OF GRATITUDE AND 169 00:06:43,600 --> 00:06:45,320 APPRECIATION FOR IN HIS HUMBLE 170 00:06:45,320 --> 00:06:47,240 WAY FOR ELEVATING THE ORAL 171 00:06:47,240 --> 00:06:49,080 HEALTH PROFESSION, FOR STANDING 172 00:06:49,080 --> 00:06:50,920 BY US THROUGH ALL OF THESE 173 00:06:50,920 --> 00:06:54,240 WONDERFUL ADVENTURES THAT HE'S 174 00:06:54,240 --> 00:06:55,640 HAD, AND IT'S JUST A PRIVILEGE 175 00:06:55,640 --> 00:06:56,960 TO HAVE HAD THE OPPORTUNITY TO 176 00:06:56,960 --> 00:07:00,120 WORK WITH LARRY AND TO BE KIND 177 00:07:00,120 --> 00:07:03,760 OF JUST LOOKING UP AT HIM IN THE 178 00:07:03,760 --> 00:07:05,640 WAY HE ADMINISTERS WITH SUCH 179 00:07:05,640 --> 00:07:08,000 SAVVY AND SUCH GRACE. 180 00:07:08,000 --> 00:07:10,080 LARRY, IF YOU'RE HERE, PLEASE 181 00:07:10,080 --> 00:07:12,800 TAKE OVER AND I'LL DO ONE MORE 182 00:07:12,800 --> 00:07:14,440 THING, WHICH IS TO SAY AT THE 183 00:07:14,440 --> 00:07:17,200 END OF OUR OPEN SESSION, TOWARDS 184 00:07:17,200 --> 00:07:20,680 THE END, WE'LL HAVE TWO 185 00:07:20,680 --> 00:07:22,000 WONDERFUL SPEAKERS, SUSAN IS AN 186 00:07:22,000 --> 00:07:26,840 EXPERT IN DATA SCIENCE TALKING 187 00:07:26,840 --> 00:07:30,080 ABOUT THE NIH'S PLANS AND NIKI 188 00:07:30,080 --> 00:07:32,520 MOUTSOPOULOS, WHOSE WORK I WILL 189 00:07:32,520 --> 00:07:34,920 BRIEFLY MENTION, FORGING NEW 190 00:07:34,920 --> 00:07:38,760 PATHS IN UNDERSTANDING OF 191 00:07:38,760 --> 00:07:43,360 INFORMATION AND IN MUCOSAL 192 00:07:43,360 --> 00:07:45,000 IMMUNITY AND PERIODONTAL 193 00:07:45,000 --> 00:07:45,200 DISEASE. 194 00:07:45,200 --> 00:07:46,280 LARRY, WELCOME AND THANK YOU FOR 195 00:07:46,280 --> 00:07:50,000 TAKING THE TIME TO BE WITH US. 196 00:07:50,000 --> 00:07:51,760 IF YOU'RE NOT QUITE THERE, LET 197 00:07:51,760 --> 00:08:00,080 ME GET OUT OF HERE, SORRY. 198 00:08:00,080 --> 00:08:02,160 199 00:08:02,160 --> 00:08:08,480 WE STILL HAVE 8 MINUTES. 200 00:08:08,480 --> 00:08:09,320 IS HE ON? 201 00:08:09,320 --> 00:08:11,120 >> RENA, I CAN TAKE THIS FEW 202 00:08:11,120 --> 00:08:12,880 MINUTES TO DO THE FIRST ORDER OF 203 00:08:12,880 --> 00:08:13,160 BUSINESS. 204 00:08:13,160 --> 00:08:14,720 >> THAT WOULD BE NICE. 205 00:08:14,720 --> 00:08:16,480 >> YEAH, THE APPROVAL OF THE 206 00:08:16,480 --> 00:08:20,160 MINUTES. 207 00:08:20,160 --> 00:08:22,840 THE MINUTES FROM THE JANUARY 208 00:08:22,840 --> 00:08:24,240 2022 MEETING WERE MADE AVAILABLE 209 00:08:24,240 --> 00:08:26,440 TO COUNCIL MEMBERS FOR REVIEW. 210 00:08:26,440 --> 00:08:28,600 AT THIS POINT WE ASK FOR 211 00:08:28,600 --> 00:08:30,160 COMMENTS OR CORRECTIONS TO THE 212 00:08:30,160 --> 00:08:33,720 MINUTES THAT ANYONE WOULD LIKE 213 00:08:33,720 --> 00:08:37,280 TO RAISE. 214 00:08:37,280 --> 00:08:39,360 IF THERE ARE NO COMMENTS OR 215 00:08:39,360 --> 00:08:41,080 QUESTIONS, WOULD A MEMBER OF 216 00:08:41,080 --> 00:08:44,720 COUNCIL LIKE TO MAKE A MOTION TO 217 00:08:44,720 --> 00:08:46,160 APPROVE THE MINUTES? 218 00:08:46,160 --> 00:08:48,480 >> I'LL MOVE. 219 00:08:48,480 --> 00:08:54,400 IS THERE SOMEONE TO SECOND THAT 220 00:08:54,400 --> 00:08:54,600 MOTION? 221 00:08:54,600 --> 00:08:57,920 >> SECOND. 222 00:08:57,920 --> 00:08:59,840 HAL EBERTINO. 223 00:08:59,840 --> 00:09:01,360 >> ALL IN FAVOR? 224 00:09:01,360 --> 00:09:01,800 >> AYE. 225 00:09:01,800 --> 00:09:02,920 >> ANY OPPOSED? 226 00:09:02,920 --> 00:09:03,160 OKAY. 227 00:09:03,160 --> 00:09:04,440 SO WE'VE COMPLETED THAT ACTION. 228 00:09:04,440 --> 00:09:07,720 AND THE NEXT ON THE AGENDA IS 229 00:09:07,720 --> 00:09:09,120 DR. TABAK. 230 00:09:09,120 --> 00:09:19,640 WHO SHOULD BE JOINING US IN A 231 00:09:19,640 --> 00:09:20,400 FEW MINUTES. 232 00:09:20,400 --> 00:09:21,960 >> MY TALK IS TO REFRESH, FOR 233 00:09:21,960 --> 00:09:24,120 THOSE WHO READ THE MINUTES IT'S 234 00:09:24,120 --> 00:09:27,000 RECORDED THERE, THAT WE DO WANT 235 00:09:27,000 --> 00:09:28,400 TO TAKE ADVANTAGE EVEN MORE SO 236 00:09:28,400 --> 00:09:32,120 THAN IN THE PAST OF THE GREAT 237 00:09:32,120 --> 00:09:34,080 PRIVILEGE AND RESOURCES WE HAVE 238 00:09:34,080 --> 00:09:37,360 AMONGST OUR COUNCIL MEMBERS, TO 239 00:09:37,360 --> 00:09:40,680 BE ABLE TO UTILIZE THE EXPERTISE 240 00:09:40,680 --> 00:09:43,920 AND COUNCIL AND BRING THE VOICE 241 00:09:43,920 --> 00:09:46,120 OF THE EXTRAMURAL COMMUNITY INTO 242 00:09:46,120 --> 00:09:47,320 OUR PLANNING AND PROCESS AND 243 00:09:47,320 --> 00:09:47,920 STRATEGIC THINKING. 244 00:09:47,920 --> 00:09:51,520 IT'S GOING TO BE CRITICAL FOR 245 00:09:51,520 --> 00:09:51,880 NIDCR. 246 00:09:51,880 --> 00:09:54,240 TODAY WOULD BE LAUNCHING INTO 247 00:09:54,240 --> 00:09:56,760 THE WORKING GROUP FORMAT WHERE 248 00:09:56,760 --> 00:09:58,960 WE'VE BEEN VERY SELECTIVE AND 249 00:09:58,960 --> 00:10:00,360 DISCREET IN PICKING WHO FOCUS 250 00:10:00,360 --> 00:10:02,200 AREAS FROM A LONG LIST, AND ONE 251 00:10:02,200 --> 00:10:04,720 OF THEM IS DATA SCIENCE, AS WE 252 00:10:04,720 --> 00:10:08,360 WOULD EXPECT, TO LOOK AT WAYS IN 253 00:10:08,360 --> 00:10:10,240 WHICH NIDCR CAN CAPTURE ITS 254 00:10:10,240 --> 00:10:12,480 RESOURCES AS THEY STAND TODAY, 255 00:10:12,480 --> 00:10:14,800 AND EXPAND THEM TO THE ADVANTAGE 256 00:10:14,800 --> 00:10:16,240 OF OUR PATIENTS AND OUR 257 00:10:16,240 --> 00:10:17,680 COMMUNITIES AND CLINICIANS AND 258 00:10:17,680 --> 00:10:19,600 OUR EDUCATORS. 259 00:10:19,600 --> 00:10:21,240 AND YOU CAN THINK OF SOMETHING 260 00:10:21,240 --> 00:10:23,880 TO BE TALKED ABOUT FOR A LONG 261 00:10:23,880 --> 00:10:25,640 TIME, INTEGRATION OF COMBINED 262 00:10:25,640 --> 00:10:26,840 HEALTH RECORDS IS ONE ASPECT. 263 00:10:26,840 --> 00:10:30,560 BUT YOU CAN GO ALL THE WAY INTO 264 00:10:30,560 --> 00:10:31,640 ARTIFICIAL INTELLIGENCE AND 265 00:10:31,640 --> 00:10:33,400 MACHINE LEARNING TOOLS THAT NOW 266 00:10:33,400 --> 00:10:35,920 ARE REALLY TRULY AVAILABLE TO US 267 00:10:35,920 --> 00:10:37,440 AS SCHOOLS INVEST IN DIGITAL 268 00:10:37,440 --> 00:10:39,840 TECHNOLOGY, SO THAT WE CAN 269 00:10:39,840 --> 00:10:42,240 ACTUALLY USE IT FOR TO 270 00:10:42,240 --> 00:10:43,240 IMPROVE -- FOR THE GOOD OF 271 00:10:43,240 --> 00:10:45,120 SOCIETY, THE GOOD OF ALL, THAT 272 00:10:45,120 --> 00:10:48,520 WE CAN TRACK DOWN HEALTH 273 00:10:48,520 --> 00:10:49,520 DISPARITIES THROUGH MODEL 274 00:10:49,520 --> 00:10:50,720 SYSTEMS WOULD BE TRUE ADVANTAGES 275 00:10:50,720 --> 00:10:51,680 FOR THE FUTURE. 276 00:10:51,680 --> 00:10:59,440 WE'RE GOING TO HAVE A TEAM OF 277 00:10:59,440 --> 00:11:00,960 EXPERTS, STRUCTURED PROCESS THAT 278 00:11:00,960 --> 00:11:02,600 NIH PRESCRIBES HOW A WORKING 279 00:11:02,600 --> 00:11:03,800 GROUP MUST FUNCTION WITH MEMBERS 280 00:11:03,800 --> 00:11:06,200 OF COUNCIL AS WELL AS THOSE 281 00:11:06,200 --> 00:11:07,600 RECRUITED FROM THE EXTRAMURAL 282 00:11:07,600 --> 00:11:09,080 COMMUNITY WHO ARE THOUGHT 283 00:11:09,080 --> 00:11:10,280 LEADERS AND EXPERTS. 284 00:11:10,280 --> 00:11:12,360 THEY WILL SPEND TIME IN THIS 285 00:11:12,360 --> 00:11:13,800 CASE PROBABLY ABOUT A YEAR, 286 00:11:13,800 --> 00:11:16,400 PERHAPS GIVING US UPDATES OF 287 00:11:16,400 --> 00:11:18,320 PROGRESS REPORTS, AS WE PROGRESS 288 00:11:18,320 --> 00:11:19,240 THROUGH COUNCIL THROUGH THE 289 00:11:19,240 --> 00:11:22,120 YEAR, AND THEN COME BACK WITH A 290 00:11:22,120 --> 00:11:23,680 DISCRETE SET OF RECOMMENDATIONS. 291 00:11:23,680 --> 00:11:28,360 SO WE BALANCE THAT INITIATIVE, 292 00:11:28,360 --> 00:11:31,320 WHICH IS VERY EMERGING AND 293 00:11:31,320 --> 00:11:34,360 VISIONARY IN MANY WAYS BUT WITH 294 00:11:34,360 --> 00:11:35,280 REALISTIC CONTEXT OF WHAT 295 00:11:35,280 --> 00:11:36,920 RESOURCES ARE NEED AND HOW WE 296 00:11:36,920 --> 00:11:38,440 CAN PROGRESS EXTRAMURALLY AND 297 00:11:38,440 --> 00:11:38,800 EXTRAMURALLY. 298 00:11:38,800 --> 00:11:40,320 THE OTHER QUESTION THAT IS VERY 299 00:11:40,320 --> 00:11:41,840 CRITICAL IS FOR US TO TAKE A 300 00:11:41,840 --> 00:11:47,440 GOOD LOOK AT HOW WE'RE TRAINING 301 00:11:47,440 --> 00:11:51,920 OUR WORKFORCE, OF CLINICIAN 302 00:11:51,920 --> 00:11:53,520 SCHOLARS/SCIENTISTS, FOR THE 303 00:11:53,520 --> 00:11:56,840 FUTURE, ARE WE TAPPING INTO 304 00:11:56,840 --> 00:12:02,320 RESOURCES, IS IT TIME TO LOOK AT 305 00:12:02,320 --> 00:12:04,640 THE RETURN OF INVESTMENT, LOOK 306 00:12:04,640 --> 00:12:06,240 AT OUR Ks AND Fs AND ANY 307 00:12:06,240 --> 00:12:08,720 OTHER WAY WE CAN ENRICH THAT 308 00:12:08,720 --> 00:12:09,760 WORKFORCE FOR THE FUTURE. 309 00:12:09,760 --> 00:12:11,840 THE TIME HAS COME TO TRANSLATE. 310 00:12:11,840 --> 00:12:14,360 THOSE ARE THE TWO WORKING 311 00:12:14,360 --> 00:12:17,560 GROUPS, THE SECOND ONE IS GOING 312 00:12:17,560 --> 00:12:19,160 TO BE LED BY DANA GRAVES AT THE 313 00:12:19,160 --> 00:12:20,240 UNIVERSITY OF PENNSYLVANIA, HE 314 00:12:20,240 --> 00:12:23,120 WILL FOLLOW THE SAME PROTOCOL 315 00:12:23,120 --> 00:12:27,720 AND DELIVER FOR US A SET OF VERY 316 00:12:27,720 --> 00:12:30,760 DISCRETE FORWARD-LOOKING 317 00:12:30,760 --> 00:12:33,040 INITIATIVES THAT WE CAN 318 00:12:33,040 --> 00:12:33,760 HIGHLIGHT 75th ANNIVERSARY 319 00:12:33,760 --> 00:12:35,560 CELEBRATION WITH NEXT YEAR. 320 00:12:35,560 --> 00:12:38,640 WITH THAT, IS LARRY ON BOARD? 321 00:12:38,640 --> 00:12:39,960 NOT AS YET. 322 00:12:39,960 --> 00:12:43,440 SO HE IS -- OKAY, THREE MORE 323 00:12:43,440 --> 00:12:44,040 MINUTES. 324 00:12:44,040 --> 00:12:45,280 >> HERE. 325 00:12:45,280 --> 00:12:46,200 >> OH, HERE'S LARRY. 326 00:12:46,200 --> 00:12:47,280 YOU MISSED ALL THE GOOD THINGS I 327 00:12:47,280 --> 00:12:48,840 SAID ABOUT YOU. 328 00:12:48,840 --> 00:12:50,120 >> GOOD, I'M GLAD. 329 00:12:50,120 --> 00:12:53,200 NO, THANKS. 330 00:12:53,200 --> 00:12:54,840 GOOD MORNING, EVERYBODY. 331 00:12:54,840 --> 00:12:57,160 SO, I DON'T KNOW IF YOU ALL WANT 332 00:12:57,160 --> 00:12:59,240 TO DRIVE MY SLIDES OR IF YOU 333 00:12:59,240 --> 00:13:00,920 PREFER THAT I SHARE MY SCREEN, 334 00:13:00,920 --> 00:13:02,160 WHAT'S BEST FOR YOU? 335 00:13:02,160 --> 00:13:04,120 >> I THINK IT'S BEST THAT YOU DO 336 00:13:04,120 --> 00:13:05,560 IT YOURSELF, LARRY. 337 00:13:05,560 --> 00:13:05,840 >> OKAY. 338 00:13:05,840 --> 00:13:11,160 JUST GIVE ME A MOMENT TO 339 00:13:11,160 --> 00:13:11,560 NAVIGATE THAT. 340 00:13:11,560 --> 00:13:13,160 NO MATTER HOW MANY TIMES I DO 341 00:13:13,160 --> 00:13:14,680 IT, I NEVER GET IT RIGHT THE 342 00:13:14,680 --> 00:13:21,120 FIRST TIME. 343 00:13:21,120 --> 00:13:31,240 OKAY. 344 00:13:34,040 --> 00:13:35,840 >> SHARE SCREEN, YEAH. 345 00:13:35,840 --> 00:13:37,680 >> WELL, SO NOW YOU'RE SEEING 346 00:13:37,680 --> 00:13:38,960 PRESENTER MODE. 347 00:13:38,960 --> 00:13:40,160 DID THAT NOW WORK? 348 00:13:40,160 --> 00:13:42,680 >> IT'S SHOWING UP AS A TINY 349 00:13:42,680 --> 00:13:44,560 SCREEN ON MY LEFT. 350 00:13:44,560 --> 00:13:48,120 HAVE YOU PRESSED SHARE SCREEN, 351 00:13:48,120 --> 00:13:48,320 LARRY? 352 00:13:48,320 --> 00:13:49,360 >> YEAH, OF COURSE. 353 00:13:49,360 --> 00:13:51,600 SOMETIMES YOU HAVE TO STOP 354 00:13:51,600 --> 00:13:55,200 SHARING AND RESHARE. 355 00:13:55,200 --> 00:13:56,400 LET'S TRY THAT TRICK. 356 00:13:56,400 --> 00:13:59,440 LET'S SEE IF THAT WORKED. 357 00:13:59,440 --> 00:14:06,840 358 00:14:06,840 --> 00:14:07,400 359 00:14:07,400 --> 00:14:08,720 >> FOR THOSE THAT JOINED LATE 360 00:14:08,720 --> 00:14:13,640 THERE'S NO BETTER PERSON TO GIVE 361 00:14:13,640 --> 00:14:13,960 THIS. 362 00:14:13,960 --> 00:14:16,080 WHAT LARRY WILL TALK ABOUT IS 363 00:14:16,080 --> 00:14:18,240 NOT -- I MADE SURE I WOULDN'T 364 00:14:18,240 --> 00:14:22,520 COVER THE TOPICS OF COVID AND 365 00:14:22,520 --> 00:14:23,840 BUDGETS AND THINGS LIKE THAT 366 00:14:23,840 --> 00:14:26,040 BECAUSE LARRY WILL TOUCH ON 367 00:14:26,040 --> 00:14:26,760 THOSE. 368 00:14:26,760 --> 00:14:27,720 >> MAYBE. 369 00:14:27,720 --> 00:14:27,920 OKAY. 370 00:14:27,920 --> 00:14:29,520 DID THAT WORK? 371 00:14:29,520 --> 00:14:33,240 >> NO. 372 00:14:33,240 --> 00:14:34,240 KEVIN, CAN YOU TROUBLESHOOT? 373 00:14:34,240 --> 00:14:35,800 >> EVERYTHING SHOULD BE GOOD 374 00:14:35,800 --> 00:14:35,960 NOW. 375 00:14:35,960 --> 00:14:37,520 >> IT'S NOW OKAY? 376 00:14:37,520 --> 00:14:38,160 >> GREAT. 377 00:14:38,160 --> 00:14:38,920 >> AH, WONDERFUL. 378 00:14:38,920 --> 00:14:40,800 WELL, THANK YOU. 379 00:14:40,800 --> 00:14:44,880 I APOLOGIZE FOR NOT BEING ABLE 380 00:14:44,880 --> 00:14:48,520 TO DO THIS IN A FACILE WAY. 381 00:14:48,520 --> 00:14:52,200 SO GOOD MORNING, EVERYBODY. 382 00:14:52,200 --> 00:14:55,600 GOOD TO BE HOME AGAIN AND WE'LL 383 00:14:55,600 --> 00:14:59,360 COVER TOPICS THAT ARE LISTED 384 00:14:59,360 --> 00:15:00,200 HERE THIS MORNING. 385 00:15:00,200 --> 00:15:06,440 SO IT'S GOING TO BE A RAPID 386 00:15:06,440 --> 00:15:07,960 SERIES OF COMMENTS. 387 00:15:07,960 --> 00:15:09,160 LET'S BEGIN WITH LEADERSHIP 388 00:15:09,160 --> 00:15:09,480 CHANGES. 389 00:15:09,480 --> 00:15:12,560 AS I THINK YOU ALL KNOW, FRANCIS 390 00:15:12,560 --> 00:15:15,080 COLLINS STEPPED DOWN AS NIH 391 00:15:15,080 --> 00:15:17,000 DIRECTOR TOWARDS THE END OF 392 00:15:17,000 --> 00:15:18,720 DECEMBER OF LAST YEAR. 393 00:15:18,720 --> 00:15:20,560 AND IT WAS INTERESTING, NOBODY 394 00:15:20,560 --> 00:15:24,160 REALLY NOTICED THAT I HAD TAKEN 395 00:15:24,160 --> 00:15:26,240 OVER AS ACTING DIRECTOR UNTIL 396 00:15:26,240 --> 00:15:32,800 THIS ARTICLE APPEARED IN THE 397 00:15:32,800 --> 00:15:33,240 SYRACUSE NEWSPAPER. 398 00:15:33,240 --> 00:15:35,800 IT WAS ALSO IN THE BUFFALO 399 00:15:35,800 --> 00:15:37,080 NEWSPAPER, ABOUT THIS FORMER 400 00:15:37,080 --> 00:15:38,440 UPSTATE NEW YORK DENTIST WHO 401 00:15:38,440 --> 00:15:40,040 TOOK OVER NIH. 402 00:15:40,040 --> 00:15:41,440 BUT OF COURSE THE PUNCHLINE IS 403 00:15:41,440 --> 00:15:45,080 THAT I BECAME DR. FAUCI'S BOSS. 404 00:15:45,080 --> 00:15:50,000 THIS IS WHAT ATTRACTED ALL THE 405 00:15:50,000 --> 00:15:50,600 ATTENTION. 406 00:15:50,600 --> 00:15:52,760 AND SO WE ALL GOT A GOOD CHUCKLE 407 00:15:52,760 --> 00:15:55,080 OUT OF THIS ONE. 408 00:15:55,080 --> 00:15:58,120 ALL KIDDING ASIDE, THERE HAVE 409 00:15:58,120 --> 00:16:01,280 BEEN A SERIES OF LEADERSHIP 410 00:16:01,280 --> 00:16:02,120 CHANGES DURING THIS TRANSITIONAL 411 00:16:02,120 --> 00:16:03,240 PERIOD I WANT TO DRAW YOUR 412 00:16:03,240 --> 00:16:07,120 ATTENTION TO. 413 00:16:07,120 --> 00:16:11,160 THE FIRST IS THAT I ASSUME THE 414 00:16:11,160 --> 00:16:15,640 ROLE OF DIRECTOR, DR. TARA 415 00:16:15,640 --> 00:16:19,960 SCHWETZ HAS MOVE INTO THE NIH 416 00:16:19,960 --> 00:16:25,520 PRINCIPAL DEPUTY DIRECTOR ROLE. 417 00:16:25,520 --> 00:16:26,840 ADDITIONALLY, COURTNEY AKLIN HAS 418 00:16:26,840 --> 00:16:31,880 NOW TAKEN TARA'S PLACE AS ACTING 419 00:16:31,880 --> 00:16:35,680 ASSOCIATE DEPUTY DIRECTOR FOR 420 00:16:35,680 --> 00:16:35,840 NIH. 421 00:16:35,840 --> 00:16:37,480 FINALLY LYRIC JORGENSON IS 422 00:16:37,480 --> 00:16:38,840 ACTING DIRECTOR OF OFFICE OF 423 00:16:38,840 --> 00:16:39,960 SCIENCE POLICY. 424 00:16:39,960 --> 00:16:45,440 WE'RE REALLY, REALLY LUCKY TO 425 00:16:45,440 --> 00:16:47,240 HAVE SUCH TALENTED LEADERS STEP 426 00:16:47,240 --> 00:16:48,840 UP AND TAKE ON THESE ACTING 427 00:16:48,840 --> 00:16:51,240 ROLES DURING THIS TIME OF 428 00:16:51,240 --> 00:16:52,480 TRANSITION. 429 00:16:52,480 --> 00:16:54,560 AND I AM EXTREMELY GRATEFUL TO 430 00:16:54,560 --> 00:16:57,920 THEM FOR ALL THE WORK THEY ARE 431 00:16:57,920 --> 00:16:58,400 DOING. 432 00:16:58,400 --> 00:17:00,680 IN THESE THREE WOMEN YOU'RE 433 00:17:00,680 --> 00:17:04,520 SEEING THE REAL FUTURE OF NIH 434 00:17:04,520 --> 00:17:04,800 LEADERSHIP. 435 00:17:04,800 --> 00:17:07,200 SO REALLY VERY PROUD TO HAVE 436 00:17:07,200 --> 00:17:11,840 THEM ON BOARD DURING THIS 437 00:17:11,840 --> 00:17:13,200 TRANSITION TIME. 438 00:17:13,200 --> 00:17:15,840 OKAY. 439 00:17:15,840 --> 00:17:18,040 SO FUNDING TRENDS, WHICH IS 440 00:17:18,040 --> 00:17:20,440 USUALLY WHAT COUNCILS ARE 441 00:17:20,440 --> 00:17:24,280 PARTICULARLY INTERESTED IN. 442 00:17:24,280 --> 00:17:28,920 SO, THIS CHART DISPLAYS THE NIH 443 00:17:28,920 --> 00:17:31,080 FUNDING FROM 1990 THROUGH 2023. 444 00:17:31,080 --> 00:17:36,560 AND THIS IS NORMALIZED TO 445 00:17:36,560 --> 00:17:37,880 $2,019, USING INFLATIONARY INDEX 446 00:17:37,880 --> 00:17:41,960 THAT WE REFER TO AS THE 447 00:17:41,960 --> 00:17:44,200 BIOMEDICAL RESEARCH AND PRICE 448 00:17:44,200 --> 00:17:48,600 INDEX, IT'S KNOWN AS BRDPI. 449 00:17:48,600 --> 00:17:52,640 AS YOU CAN SEE, BEGINNING IN 450 00:17:52,640 --> 00:18:00,520 2014, 2015, NIH HAS REALLY 451 00:18:00,520 --> 00:18:01,680 ENJOYED SUSTAINED GROWTH, THE 452 00:18:01,680 --> 00:18:06,720 RESULT OF BIPARTISAN SUPPORT 453 00:18:06,720 --> 00:18:08,960 FROM THE CONGRESS, AND THIS 454 00:18:08,960 --> 00:18:12,280 GROWTH IS KEEPING PACE WITH 455 00:18:12,280 --> 00:18:16,560 BRDPI, AND THE HOPE IS GOING 456 00:18:16,560 --> 00:18:19,160 FORWARD THAT WE SEE THIS 457 00:18:19,160 --> 00:18:21,800 SUSTAINED IN YEARS TO COME. 458 00:18:21,800 --> 00:18:24,760 SOME OF YOU MAY KNOW THAT 459 00:18:24,760 --> 00:18:29,040 YESTERDAY WE HAD OUR SENATE 460 00:18:29,040 --> 00:18:30,040 APPROPRIATIONS HEARING. 461 00:18:30,040 --> 00:18:33,920 AND CHAIR MURRAY AND RANKING 462 00:18:33,920 --> 00:18:36,880 MEMBER BLUNT BOTH EXPRESSED HOPE 463 00:18:36,880 --> 00:18:42,920 THAT NIH WOULD CONTINUE ON THIS 464 00:18:42,920 --> 00:18:45,320 PATHWAY OF GROWTH, BOTH THE 465 00:18:45,320 --> 00:18:47,960 CHAIR MURRAY AND THE RANKING 466 00:18:47,960 --> 00:18:50,240 MEMBER BLUNT HAVE BEEN 467 00:18:50,240 --> 00:18:52,760 EXTRAORDINARILY STALWART IN 468 00:18:52,760 --> 00:18:55,200 THEIR SUPPORT NIH. 469 00:18:55,200 --> 00:18:58,600 SADLY, THIS LIKELY WAS THE LAST 470 00:18:58,600 --> 00:19:02,600 HEARING FOR NIH THAT MR. BLUNT 471 00:19:02,600 --> 00:19:06,280 WILL APPEAR AT, AS HE ANNOUNCED 472 00:19:06,280 --> 00:19:07,480 HIS RETIREMENT FROM THE SENATE 473 00:19:07,480 --> 00:19:14,720 AT THE CLOSE OF THE SESSION. 474 00:19:14,720 --> 00:19:15,600 BUT PRESUMABLY SENATOR MURRAY 475 00:19:15,600 --> 00:19:17,560 WILL CONTINUE HER GOOD WORK IN 476 00:19:17,560 --> 00:19:24,200 THIS SPACE, TOGETHER WITH 477 00:19:24,200 --> 00:19:26,440 WHOMEVER SUCCEEDS MR. BLUNT. 478 00:19:26,440 --> 00:19:28,800 NOW, IF YOU LOOK AT THE 21 479 00:19:28,800 --> 00:19:34,880 BUDGET AT A HIGH LEVEL, IN THE 480 00:19:34,880 --> 00:19:38,120 DIFFERENT BUCKETS THAT WE 481 00:19:38,120 --> 00:19:40,000 SUPPORT, OVERWHELMINGLY OUR 482 00:19:40,000 --> 00:19:43,200 RESOURCES ARE DIRECTED TO 483 00:19:43,200 --> 00:19:46,120 RESEARCH PROJECT GRANTS, WITH A 484 00:19:46,120 --> 00:19:49,320 MUCH SMALLER AMOUNT TO OTHER 485 00:19:49,320 --> 00:19:52,040 CATEGORIES SUCH AS RESEARCH 486 00:19:52,040 --> 00:19:54,560 CENTERS AND TRAINING. 487 00:19:54,560 --> 00:19:57,560 THE INTRAMURAL RESEARCH PROGRAM 488 00:19:57,560 --> 00:20:01,800 IS ROUGHLY 10 TO 11% OF THE 489 00:20:01,800 --> 00:20:06,840 OVERALL BUDGET, AND THE 490 00:20:06,840 --> 00:20:10,120 SBIR/STTR, THE SMALL BUSINESS 491 00:20:10,120 --> 00:20:10,880 PROGRAM CONGRESSIONALLY MANDATED 492 00:20:10,880 --> 00:20:14,040 AT $1.2 BILLION, IN 2021. 493 00:20:14,040 --> 00:20:19,920 WHAT IS NOT DISPLAYED IN ANY OF 494 00:20:19,920 --> 00:20:23,480 THE PRECEDING TWO CHARTS ARE THE 495 00:20:23,480 --> 00:20:24,440 EMERGENCY SUPPLEMENTAL FUNDS FOR 496 00:20:24,440 --> 00:20:28,080 COVID-19 THAT THE CONGRESS HAS 497 00:20:28,080 --> 00:20:29,560 GENEROUSLY SUPPORTED US WITH, 498 00:20:29,560 --> 00:20:31,480 AND THESE ARE DISPLAYED HERE 499 00:20:31,480 --> 00:20:35,040 JUST TO SERVE AS A REMINDER OF 500 00:20:35,040 --> 00:20:36,600 THE ADDITIONAL RESOURCES THAT 501 00:20:36,600 --> 00:20:40,200 NIH HAS BEEN ABLE TO MOBILIZE TO 502 00:20:40,200 --> 00:20:42,240 THE COVID RESPONSE WHICH I'LL 503 00:20:42,240 --> 00:20:44,720 COVER IN A LITTLE BIT MORE 504 00:20:44,720 --> 00:20:46,960 DETAIL IN A MOMENT. 505 00:20:46,960 --> 00:20:50,480 MOST OF THE RESOURCES 506 00:20:50,480 --> 00:20:52,760 UNDERSTANDABLY WENT TO NIAID, 507 00:20:52,760 --> 00:20:57,120 BUT SOME RESOURCES WENT TO OTHER 508 00:20:57,120 --> 00:20:57,920 ENTITIES AROUND NIH. 509 00:20:57,920 --> 00:21:01,960 THE WORK IN THE OFFICE OF THE 510 00:21:01,960 --> 00:21:05,640 DIRECTOR WAS REDISTRIBUTED TO 511 00:21:05,640 --> 00:21:08,720 SUPPORT ASPECTS OF THE SO-CALLED 512 00:21:08,720 --> 00:21:10,120 RADx PROGRAM, WHICH I'LL TOUCH 513 00:21:10,120 --> 00:21:14,000 UPON IN A BIT. 514 00:21:14,000 --> 00:21:18,040 BUT THIS IS MOSTLY RELATED TO 515 00:21:18,040 --> 00:21:20,560 RECOVER FUNDS, WHICH WE'LL BE 516 00:21:20,560 --> 00:21:23,480 INVOLVED WITH, WHICH IS A LONG 517 00:21:23,480 --> 00:21:25,600 STUDY ON LONG COVID, AND THEN 518 00:21:25,600 --> 00:21:28,200 ALSO TO THE COMMON FUND WHICH 519 00:21:28,200 --> 00:21:32,160 ALSO BECAME ENGAGED IN SOME OF 520 00:21:32,160 --> 00:21:34,480 THE SUPPLEMENTAL WORK. 521 00:21:34,480 --> 00:21:37,840 NOW, THE 22 APPROPRIATIONS AS 522 00:21:37,840 --> 00:21:39,200 YOU KNOW WE RECENTLY RECEIVED IN 523 00:21:39,200 --> 00:21:45,040 THE FORM OF AN OMNIBUS, GENERAL 524 00:21:45,040 --> 00:21:48,360 INCREASE FOR INSTITUTES AND 525 00:21:48,360 --> 00:21:50,560 CENTERS 3.4%, OVERALL 5.2% 526 00:21:50,560 --> 00:21:52,720 INCREASE OVER FISCAL YEAR 21 527 00:21:52,720 --> 00:21:55,480 WHICH WAS QUITE REMARKABLE GIVEN 528 00:21:55,480 --> 00:21:57,800 THE LANDSCAPE, SPECIFIC 529 00:21:57,800 --> 00:22:02,360 INCREASES ARE OUTLINED HERE. 530 00:22:02,360 --> 00:22:03,920 AND THESE INCLUDE SIGNIFICANT 531 00:22:03,920 --> 00:22:08,520 INCREASE FOR ALZHEIMER'S DISEASE 532 00:22:08,520 --> 00:22:10,760 RESEARCH, FOR CANCER, OPIOIDS, 533 00:22:10,760 --> 00:22:13,760 THE BRAIN INITIATIVE, AND THE 534 00:22:13,760 --> 00:22:15,720 HEALTH DISPARITIES RESEARCH. 535 00:22:15,720 --> 00:22:18,880 THE PRESIDENT'S BUDGET WHICH WE 536 00:22:18,880 --> 00:22:21,640 WERE DEFENDING YESTERDAY IN THE 537 00:22:21,640 --> 00:22:28,760 SENATE AND PREVIOUS WEEK IN THE 538 00:22:28,760 --> 00:22:32,920 HOUSE INCLUDES $16.3 BILLION 539 00:22:32,920 --> 00:22:34,600 INCREASE, BUT OF THAT, 540 00:22:34,600 --> 00:22:36,720 $12.05 BILLION ARE MANDATORY 541 00:22:36,720 --> 00:22:37,920 RELATED TO PANDEMIC 542 00:22:37,920 --> 00:22:39,400 PREPAREDNESS. 543 00:22:39,400 --> 00:22:42,840 SO THAT'S REALLY A SEPARATE 544 00:22:42,840 --> 00:22:45,800 BUCKET OF MONEY. 545 00:22:45,800 --> 00:22:49,080 AND THEN $4 BILLION DIRECTED TO 546 00:22:49,080 --> 00:22:53,200 ARPA-H, AND THEN THE REMAINING 547 00:22:53,200 --> 00:22:54,800 INCREASES ARE DISPLAYED. 548 00:22:54,800 --> 00:22:57,560 WE'VE ASKED FOR VERY LARGE 549 00:22:57,560 --> 00:22:59,000 INCREASE IN HEALTH DISPARITIES 550 00:22:59,000 --> 00:23:00,200 RESEARCH FOR NEW RESOURCES 551 00:23:00,200 --> 00:23:04,280 RELATED TO CLIMATE CHANGE AND 552 00:23:04,280 --> 00:23:05,120 NUTRITION SCIENCE. 553 00:23:05,120 --> 00:23:10,920 A LOT HAS BEEN MADE ABOUT THE 554 00:23:10,920 --> 00:23:14,960 BUDGET NUMBERS IN FISCAL YEAR 23 555 00:23:14,960 --> 00:23:19,440 REQUEST BY THE ADMINISTRATION, 556 00:23:19,440 --> 00:23:21,400 VERSUS THE FISCAL YEAR 22 557 00:23:21,400 --> 00:23:24,160 OMNIBUS, OUR CURRENT FISCAL 558 00:23:24,160 --> 00:23:24,480 YEAR. 559 00:23:24,480 --> 00:23:27,240 AND AS I EXPLAINED YESTERDAY IN 560 00:23:27,240 --> 00:23:32,240 THE SENATE AND PRECEDING WEEK IN 561 00:23:32,240 --> 00:23:34,080 THE HOUSE, THE SEEMINGLY MODEST 562 00:23:34,080 --> 00:23:36,160 BUDGET INCREASE INDEED IN SOME 563 00:23:36,160 --> 00:23:38,600 INSTANCES DISPLAYED FOR 564 00:23:38,600 --> 00:23:41,120 INSTITUTES AND CENTERS A 565 00:23:41,120 --> 00:23:45,960 DECREASE IS REALLY THE RESULT OF 566 00:23:45,960 --> 00:23:46,320 TIMING ARTIFACT. 567 00:23:46,320 --> 00:23:48,240 THE ADMINISTRATION NEEDED TO PUT 568 00:23:48,240 --> 00:23:50,880 ITS BUDGET TOGETHER BASED UPON A 569 00:23:50,880 --> 00:23:52,120 BASELINE THAT WAS AVAILABLE AT 570 00:23:52,120 --> 00:23:54,040 THE TIME, AND AT THE TIME THE 571 00:23:54,040 --> 00:23:57,160 BUDGET WAS PUT TOGETHER THE ONLY 572 00:23:57,160 --> 00:23:59,240 BASELINE AVAILABLE WAS THE 573 00:23:59,240 --> 00:24:00,400 CONTINUING RESOLUTION. 574 00:24:00,400 --> 00:24:03,120 WE WERE VERY FORTUNATE THAT THE 575 00:24:03,120 --> 00:24:05,520 CONGRESS WENT WELL BEYOND THE 576 00:24:05,520 --> 00:24:06,880 CONTINUING RESOLUTION IN 577 00:24:06,880 --> 00:24:08,240 PROVIDING US WITH AN INCREASE 578 00:24:08,240 --> 00:24:12,000 THIS PHYSICAL FISCAL YEAR IN 579 00:24:12,000 --> 00:24:13,200 THE OMNIBUS AND THEREFORE MUCH 580 00:24:13,200 --> 00:24:17,000 OF THE INCREASE PROPOSED IN THE 581 00:24:17,000 --> 00:24:21,960 23 BUDGET WAS, IF YOU WILL, 582 00:24:21,960 --> 00:24:24,160 CONSUMED BY THE INCREASE THE 583 00:24:24,160 --> 00:24:25,720 OMNIBUS ALREADY PROVIDED. 584 00:24:25,720 --> 00:24:29,000 SO ON RELATIVE TERMS IT LOOKS 585 00:24:29,000 --> 00:24:30,520 LIKE THERE'S A DECREASE RATHER 586 00:24:30,520 --> 00:24:32,920 THAN ANY INCREASE GOING FORWARD. 587 00:24:32,920 --> 00:24:34,880 AS THE SECRETARY OF HHS 588 00:24:34,880 --> 00:24:36,880 INDICATED, AND AS I INDICATED 589 00:24:36,880 --> 00:24:39,960 LAST WEEK AND YESTERDAY, TO THE 590 00:24:39,960 --> 00:24:40,960 HOUSE AND SENATE RESPECTIVELY, 591 00:24:40,960 --> 00:24:43,560 WE LOOK FORWARD TO WORKING WITH 592 00:24:43,560 --> 00:24:45,760 THE CONGRESS AS THE 23 BUDGET 593 00:24:45,760 --> 00:24:48,160 PLAYS OUT, AND THEY MADE IT 594 00:24:48,160 --> 00:24:50,920 CLEAR IN BOTH HOUSES THAT THEIR 595 00:24:50,920 --> 00:24:54,160 EXPECTATION IS THAT WE SHOULD, 596 00:24:54,160 --> 00:24:55,800 YOU KNOW, RECEIVE AN INCREASE 597 00:24:55,800 --> 00:24:57,480 HOPEFULLY IN LINE WITH THE TYPES 598 00:24:57,480 --> 00:24:59,560 OF INCREASES THAT WE'VE BEEN 599 00:24:59,560 --> 00:25:01,800 RECEIVING IN THE PAST GOING 600 00:25:01,800 --> 00:25:02,000 FORWARD. 601 00:25:02,000 --> 00:25:03,240 SO PLEASE STAY TUNED. 602 00:25:03,240 --> 00:25:05,360 THERE'S STILL QUITE A BIT TO DO 603 00:25:05,360 --> 00:25:08,200 WITH THE 23 BUDGET BEFORE WE 604 00:25:08,200 --> 00:25:11,840 KNOW WHAT THE FINAL RESULT WILL 605 00:25:11,840 --> 00:25:12,000 BE. 606 00:25:12,000 --> 00:25:14,240 SO, NOW I'D LIKE TO GIVE YOU A 607 00:25:14,240 --> 00:25:16,440 QUICK UPDATE ON THE COVID 608 00:25:16,440 --> 00:25:19,040 RESPONSE, AND I'LL GO THROUGH 609 00:25:19,040 --> 00:25:22,600 THIS RATHER RAPIDLY JUST TO GIVE 610 00:25:22,600 --> 00:25:24,480 SOME OF THE HIGHLIGHTS. 611 00:25:24,480 --> 00:25:27,920 THE PUBLIC/PRIVATE PARTNERSHIP 612 00:25:27,920 --> 00:25:30,320 KNOWN AS ACTIV WAS LAUNCHED IN 613 00:25:30,320 --> 00:25:33,400 APRIL OF 2020, WITH THE MISSION 614 00:25:33,400 --> 00:25:35,560 OF DEVELOPING A COORDINATED 615 00:25:35,560 --> 00:25:39,480 RESPONSE TO SPEED TREATMENT AND 616 00:25:39,480 --> 00:25:41,840 VACCINE OPTIONS. 617 00:25:41,840 --> 00:25:42,440 THE PARTNERSHIPS ARE DISPLAYED 618 00:25:42,440 --> 00:25:44,440 IN THE LOWER PART OF THIS SLIDE, 619 00:25:44,440 --> 00:25:49,240 AND AS YOU CAN SEE 20 INDUSTRY 620 00:25:49,240 --> 00:25:50,400 LEADERS, STAKEHOLDER GROUPS FROM 621 00:25:50,400 --> 00:25:56,120 ALL ACROSS THE UNITED STATES 622 00:25:56,120 --> 00:26:01,560 GOVERNMENT AND FOUR NOT FOR 623 00:26:01,560 --> 00:26:06,840 PROFITS AND A SHOUT OUT TO THE 624 00:26:06,840 --> 00:26:08,200 FOUNDATION FOR NIH, I CANNOT SAY 625 00:26:08,200 --> 00:26:10,680 ENOUGH FOR HOW IMPORTANT THAT 626 00:26:10,680 --> 00:26:14,600 PARTNERSHIP HAS BEEN FOR US. 627 00:26:14,600 --> 00:26:17,560 THE NET RESULT HAS BEEN 628 00:26:17,560 --> 00:26:18,120 DOCUMENTED MANY, MANY, MANY 629 00:26:18,120 --> 00:26:21,800 TIMES, HAS BEEN AN IMPRESSIVE 630 00:26:21,800 --> 00:26:23,480 ARRAY, UNPRECEDENTED TIMELINES 631 00:26:23,480 --> 00:26:28,080 FOR VACCINES AS WELL AS THE 632 00:26:28,080 --> 00:26:28,520 ANTI-VIRALS. 633 00:26:28,520 --> 00:26:30,600 THIS IS JUST A REALLY BRIEF 634 00:26:30,600 --> 00:26:33,440 SUMMARY OF THE STATUS OF THE 635 00:26:33,440 --> 00:26:35,160 CURRENT AGENTS THAT HAVE BEEN 636 00:26:35,160 --> 00:26:38,800 TESTED IN THE VARIOUS ARMS OF 637 00:26:38,800 --> 00:26:41,520 THE ACTIV EFFORT. 638 00:26:41,520 --> 00:26:43,400 THE SECOND COLUMN CEASED 639 00:26:43,400 --> 00:26:45,960 ENROLLMENT LISTS THOSE THINGS 640 00:26:45,960 --> 00:26:47,680 THAT HAVE BEEN STOPPED EITHER 641 00:26:47,680 --> 00:26:51,840 DUE TO LOW CLINICAL VALUE OR TO 642 00:26:51,840 --> 00:26:56,240 FUTILITY, ON THE FAR RIGHT 643 00:26:56,240 --> 00:27:00,600 EVERYTHING WITH COMPLETED 644 00:27:00,600 --> 00:27:08,360 ENROLLINGMENT IS DISPLAYED. 645 00:27:08,360 --> 00:27:11,600 AWAITING RESULTS, SOME WORK IS 646 00:27:11,600 --> 00:27:20,040 NOT YET REMOVED IN THE ACTIV 2 647 00:27:20,040 --> 00:27:24,800 PROTEASE INHIBITOR FROM SHENOGI, 648 00:27:24,800 --> 00:27:32,000 ADDITIONAL AGENTS IN 2/2B ARE 649 00:27:32,000 --> 00:27:33,120 AWAITING RESULTS. 650 00:27:33,120 --> 00:27:35,720 ACTIVE 3 DID NOT REACH ENDPOINT 651 00:27:35,720 --> 00:27:37,600 BUT SHOWED EFFECT ON ALL CAUSE 652 00:27:37,600 --> 00:27:40,200 MORTALITY WHICH WILL BE FOLLOWED 653 00:27:40,200 --> 00:27:41,960 UP ON. 654 00:27:41,960 --> 00:27:48,120 AND THEN SIMILARLY, THE WORK 655 00:27:48,120 --> 00:27:50,520 WITH HEPARIN, WHICH SHOWS TO BE 656 00:27:50,520 --> 00:27:55,560 QUITE USEFUL IN CERTAIN CLINICAL 657 00:27:55,560 --> 00:27:56,240 SITUATIONS. 658 00:27:56,240 --> 00:27:59,840 TOGETHER WITH OTHER EFFORTS IN 659 00:27:59,840 --> 00:28:01,920 THE VARIOUS ACTIV 4 TRIALS. 660 00:28:01,920 --> 00:28:04,400 FINALLY WE'RE WAITING FOR 661 00:28:04,400 --> 00:28:07,400 TOPLINE DATA ON VARIOUS ACTIV 5 662 00:28:07,400 --> 00:28:10,880 AND ACTIV 6 EFFORTS. 663 00:28:10,880 --> 00:28:16,680 THE LATTER PRAGMATIC TRIALS, LOW 664 00:28:16,680 --> 00:28:18,600 TOUCH DONE MOSTLY BY MAIL AND 665 00:28:18,600 --> 00:28:26,760 VIRTUALLY, WE'RE WAITING ON THE 666 00:28:26,760 --> 00:28:35,160 IVERMECTIN READOUT, AND 667 00:28:35,160 --> 00:28:35,760 FLUTICASONE, FLUVOXAMINE 668 00:28:35,760 --> 00:28:36,880 AWAITING ENROLLMENT. 669 00:28:36,880 --> 00:28:40,280 I'M OFTEN ASKED HAS THIS BEEN A 670 00:28:40,280 --> 00:28:41,880 SUCCESS BECAUSE ONLY A FEW 671 00:28:41,880 --> 00:28:43,520 THINGS CAME OUT TO SHOW EFFICACY 672 00:28:43,520 --> 00:28:44,640 AND SO FORTH. 673 00:28:44,640 --> 00:28:47,480 THE ANSWER IS THIS IS AN 674 00:28:47,480 --> 00:28:49,440 UNPARALLELED SUCCESS BECAUSE WE 675 00:28:49,440 --> 00:28:51,160 DO HAVE A SERIES OF APPROACHES 676 00:28:51,160 --> 00:28:53,640 THAT CAN BE USED IN DIFFERENT 677 00:28:53,640 --> 00:28:55,520 STAGES OF THE DISEASE, BUT 678 00:28:55,520 --> 00:28:57,200 EQUALLY IMPORTANTLY WE'VE 679 00:28:57,200 --> 00:28:59,760 LEARNED WHAT DOESN'T WORK, AND 680 00:28:59,760 --> 00:29:01,720 THAT'S SO VERY, VERY USEFUL. 681 00:29:01,720 --> 00:29:06,280 AND I HOPE PEOPLE KEEP THAT IN 682 00:29:06,280 --> 00:29:08,520 MIND BECAUSE AS YOU PARSE 683 00:29:08,520 --> 00:29:09,880 THROUGH THIS IN AN EMERGENCY 684 00:29:09,880 --> 00:29:11,480 CIRCUMSTANCE, KNOWING WHAT 685 00:29:11,480 --> 00:29:12,840 DOESN'T WORK IS EQUALLY 686 00:29:12,840 --> 00:29:15,120 IMPORTANT TO WHAT DOES. 687 00:29:15,120 --> 00:29:19,480 NOW, AS YOU ALL KNOW, 688 00:29:19,480 --> 00:29:23,640 INDIVIDUALS WHO ARE INFECTED 689 00:29:23,640 --> 00:29:26,800 WITH COVID, A PERCENTAGE OF 690 00:29:26,800 --> 00:29:30,640 PEOPLE DO GO ON WITH SO-CALLED 691 00:29:30,640 --> 00:29:34,920 LONG COVID, AND WE HAVE LAUNCHED 692 00:29:34,920 --> 00:29:36,640 A RATHER COMPREHENSIVE 693 00:29:36,640 --> 00:29:39,880 INITIATIVE KNOWN AS RECOVER TO 694 00:29:39,880 --> 00:29:40,920 REALLY IMPROVE OUR UNDERSTANDING 695 00:29:40,920 --> 00:29:44,440 OF AND OUR ABILITY TO PREDICT 696 00:29:44,440 --> 00:29:47,440 AND TREAT AND HOPEFULLY PREVENT 697 00:29:47,440 --> 00:29:49,400 LONG COVID. 698 00:29:49,400 --> 00:29:53,000 THE SCIENTIFIC AIMS ARE 699 00:29:53,000 --> 00:29:54,480 ELABORATED HERE. 700 00:29:54,480 --> 00:29:59,600 AND REALLY WE'RE STILL NOT 701 00:29:59,600 --> 00:30:01,880 EXACTLY SURE WHAT WE ARE DEALING 702 00:30:01,880 --> 00:30:04,600 WITH IN THE SENSE THAT THE 703 00:30:04,600 --> 00:30:06,040 PRESENTATION COVERS SO MANY 704 00:30:06,040 --> 00:30:08,680 DIFFERENT ORGAN SYSTEMS OF THE 705 00:30:08,680 --> 00:30:08,880 BODY. 706 00:30:08,880 --> 00:30:10,840 AND SO THE FIRST AIM 707 00:30:10,840 --> 00:30:13,720 UNDERSTANDABLY IS TO REALLY 708 00:30:13,720 --> 00:30:14,920 UNDERSTAND THAT CLINICAL 709 00:30:14,920 --> 00:30:17,320 SPECTRUM IN BIOLOGY UNDERLYING 710 00:30:17,320 --> 00:30:19,680 RECOVERY OVER TIME, WE WANTED TO 711 00:30:19,680 --> 00:30:22,840 FIND RISK FACTORS, WE WANT TO 712 00:30:22,840 --> 00:30:24,600 STUDY PATHOGENESIS, AND 713 00:30:24,600 --> 00:30:29,200 ULTIMATELY TO IDENTIFY THE 714 00:30:29,200 --> 00:30:29,880 INTERVENTIONS. 715 00:30:29,880 --> 00:30:31,360 THE GUIDING PRINCIPLES ARE 716 00:30:31,360 --> 00:30:33,720 SUMMARIZED HERE. 717 00:30:33,720 --> 00:30:37,080 THIS IS A COLLABORATION AMONG 718 00:30:37,080 --> 00:30:38,640 PATIENTS AND CAREGIVERS, 719 00:30:38,640 --> 00:30:41,040 SCIENTIFIC COMMUNITY, COMMUNITY 720 00:30:41,040 --> 00:30:42,080 AND FEDERAL PARTNERS, PRIVATE 721 00:30:42,080 --> 00:30:44,080 SECTOR, AND OF COURSE CLINICAL 722 00:30:44,080 --> 00:30:44,840 GROUPS. 723 00:30:44,840 --> 00:30:48,280 IF ALL OF THE DIFFERENT GROUPS 724 00:30:48,280 --> 00:30:51,280 DON'T WORK TOGETHER, WE WILL NOT 725 00:30:51,280 --> 00:30:54,800 BE SUCCESSFUL IN ACHIEVING OUR 726 00:30:54,800 --> 00:30:55,160 GOALS. 727 00:30:55,160 --> 00:30:59,760 THE GUIDING PRINCIPLES, PATIENT 728 00:30:59,760 --> 00:31:03,240 CENTRIC, NATIONAL SCALE TO 729 00:31:03,240 --> 00:31:04,760 ENSURE INCLUSIVE AND DIVERSE 730 00:31:04,760 --> 00:31:07,040 PARTICIPATION, WE'RE USING 731 00:31:07,040 --> 00:31:09,160 UNIFORM PLATFORMS ACROSS ALL OF 732 00:31:09,160 --> 00:31:09,680 THE EFFORTS. 733 00:31:09,680 --> 00:31:12,320 AND WE'RE GOING TO HAVE TO ADAPT 734 00:31:12,320 --> 00:31:14,280 BECAUSE AS THE VIRUS, YOU KNOW, 735 00:31:14,280 --> 00:31:16,800 ADAPTS, WE HAVE TO ADAPT. 736 00:31:16,800 --> 00:31:21,720 AND SO THIS WILL BE AN ADAPTIVE 737 00:31:21,720 --> 00:31:26,120 APPROACH, AS THE SCIENCE 738 00:31:26,120 --> 00:31:33,360 CONTINUES TO EVOLVE. 739 00:31:33,360 --> 00:31:38,720 ANOTHER ACTIVE EFFORT 740 00:31:38,720 --> 00:31:44,720 TRACK RESISTANCE TO CORONAVIRUS, 741 00:31:44,720 --> 00:31:48,440 MONITORING GLOBAL EMERGENCE AND 742 00:31:48,440 --> 00:31:49,640 CIRCULATION OF SARS-COV-2 743 00:31:49,640 --> 00:31:57,640 MUTATIONS, AND WHAT'S TAKELY 744 00:31:57,640 --> 00:31:58,400 VALUABLE -- PARTICULARLY 745 00:31:58,400 --> 00:32:00,520 VALUABLE, WHETHER THE AVAILABLE 746 00:32:00,520 --> 00:32:01,880 INTERVENTIONS ARE STILL 747 00:32:01,880 --> 00:32:03,720 EFFICACIOUS WITH THE MUTATED 748 00:32:03,720 --> 00:32:10,840 FORMS, AND THIS DATABASE IS 749 00:32:10,840 --> 00:32:14,000 CONSTANTLY BEING UPDATED AND 750 00:32:14,000 --> 00:32:15,680 INDUSTRY, ACADEMIA, AND USG FEED 751 00:32:15,680 --> 00:32:17,200 INTO THIS. 752 00:32:17,200 --> 00:32:20,480 WHICH LEADS TO A RATHER 753 00:32:20,480 --> 00:32:21,800 COMPREHENSIVE DATASET THAT HAS 754 00:32:21,800 --> 00:32:29,400 PROVEN TO BE VERY HELPFUL. 755 00:32:29,400 --> 00:32:31,640 AND THEN FINALLY, NIH, NIAID IN 756 00:32:31,640 --> 00:32:34,840 THE LEAD, HAVE A SERIES OF 757 00:32:34,840 --> 00:32:37,880 EXPERTS, A U.S. PANEL, DEVELOPED 758 00:32:37,880 --> 00:32:39,200 TREATMENT GUIDELINES FOR 759 00:32:39,200 --> 00:32:41,120 COVID-19. 760 00:32:41,120 --> 00:32:47,080 THESE ARE EVER EVOLVING. 761 00:32:47,080 --> 00:32:49,760 STARTED IN 2020, AND THERE HAVE 762 00:32:49,760 --> 00:32:51,400 BEEN 51 UPDATES. 763 00:32:51,400 --> 00:32:53,120 AS YOU CAN SEE, ALMOST 36 764 00:32:53,120 --> 00:32:54,440 MILLION PAGE VIEWS. 765 00:32:54,440 --> 00:32:57,360 SO, THIS SITE IS LOOKED AT VERY 766 00:32:57,360 --> 00:33:07,600 CAREFULLY, AND HAS REALLY GUIDED 767 00:33:07,600 --> 00:33:13,280 CLINICIANS THROUGHOUT THE NATION 768 00:33:13,280 --> 00:33:14,760 IN APPROACH TO TREATING, AND 769 00:33:14,760 --> 00:33:17,280 THIS WILL CONTINUE TO BE UPDATED 770 00:33:17,280 --> 00:33:18,040 AS IT EVOLVES. 771 00:33:18,040 --> 00:33:20,800 THE STATUS OF THE NIH CAMPUS, I 772 00:33:20,800 --> 00:33:23,320 HOPE THIS IS REDUNDANT TO WHAT 773 00:33:23,320 --> 00:33:26,960 DR. D'SOUZA SHARED, I APOLOGIZE, 774 00:33:26,960 --> 00:33:28,360 BASICALLY TRENDS IN VIRAL CASE 775 00:33:28,360 --> 00:33:30,520 LOADS AMONG OUR STAFF MIRROR THE 776 00:33:30,520 --> 00:33:31,320 REST OF THE COUNTRY. 777 00:33:31,320 --> 00:33:34,880 OVER THE PAST MONTH OR SO THINGS 778 00:33:34,880 --> 00:33:36,360 ARE TICKING UPWARDS AGAIN. 779 00:33:36,360 --> 00:33:38,640 ALL STAFF HAVE RETURNED TO THE 780 00:33:38,640 --> 00:33:40,400 PHYSICAL WORKPLACE IN SOME 781 00:33:40,400 --> 00:33:42,480 CAPACITY, BUT WE REALLY DO HAVE 782 00:33:42,480 --> 00:33:47,800 AN EXPANSION OF WORKPLACE 783 00:33:47,800 --> 00:33:48,520 FLEXIBILITIES. 784 00:33:48,520 --> 00:33:53,000 OUR OWN STAFF ARE ENGAGED IN 785 00:33:53,000 --> 00:33:54,880 VOLUNTARY TESTING PROGRAMS, 786 00:33:54,880 --> 00:33:57,440 EITHER ASYMPTOMATIC OR 787 00:33:57,440 --> 00:33:58,360 SYMPTOMATIC. 788 00:33:58,360 --> 00:33:59,880 THIS HAS BEEN SUPPLEMENTED WITH 789 00:33:59,880 --> 00:34:00,960 PROCUREMENT OF HOME ANTIGEN 790 00:34:00,960 --> 00:34:03,160 TESTS FOR STAFF, THIS WAS BEFORE 791 00:34:03,160 --> 00:34:06,640 THE FEDERAL GOVERNMENT WAS ABLE 792 00:34:06,640 --> 00:34:08,160 TO PROVIDE THIS BROADLY. 793 00:34:08,160 --> 00:34:10,080 BUT OUR STAFF HAVE BEEN ABLE TO 794 00:34:10,080 --> 00:34:20,600 USE THE ANTIGEN TESTS AS WELL AS 795 00:34:25,400 --> 00:34:26,360 AN ADJUNCT. 796 00:34:26,360 --> 00:34:28,200 WE'RE NOW AT MEDIUM, SO ANY I 797 00:34:28,200 --> 00:34:33,120 HAVES TOSH -- VISITOR HAS TO 798 00:34:33,120 --> 00:34:34,440 ATTEST TO VACCINATION OR SHOW 799 00:34:34,440 --> 00:34:37,160 RECENT NEGATIVE TEST. 800 00:34:37,160 --> 00:34:39,120 STARTING NEXT MONTH, BSCs AND 801 00:34:39,120 --> 00:34:41,200 COUNCILS WILL BE ALLOWED TO USE 802 00:34:41,200 --> 00:34:41,880 HYBRID FORMATS. 803 00:34:41,880 --> 00:34:44,280 IF WE GO TO HIGH WE'LL REVISIT 804 00:34:44,280 --> 00:34:47,120 THAT AND SADLY THE TRENDS ARE IN 805 00:34:47,120 --> 00:34:48,240 THAT DIRECTION. 806 00:34:48,240 --> 00:34:51,920 BUT WE ARE AT LEAST FOR THE 807 00:34:51,920 --> 00:34:53,840 MOMENT CONSIDERING HYBRID 808 00:34:53,840 --> 00:34:54,880 FORMATS AS BEING POSSIBLE. 809 00:34:54,880 --> 00:34:56,880 I DO KNOW MANY COUNCILS HAVE 810 00:34:56,880 --> 00:35:00,160 DETERMINED THAT THEY ARE JUST 811 00:35:00,160 --> 00:35:09,240 GOING TO REMAIN WITH THE VIRTUAL 812 00:35:09,240 --> 00:35:09,440 FORMAT. 813 00:35:09,440 --> 00:35:11,000 SO NOW I'D LIKE TO SHIFT GEARS 814 00:35:11,000 --> 00:35:12,960 AND HAVE A LITTLE FUN. 815 00:35:12,960 --> 00:35:16,080 WHENEVER I TALK ABOUT SCIENCE, 816 00:35:16,080 --> 00:35:17,680 THAT'S FUN. 817 00:35:17,680 --> 00:35:26,480 AND SO I WANTED TO TALK ABOUT 818 00:35:26,480 --> 00:35:28,960 SOME HIGHLIGHTS FROM NIDCR. 819 00:35:28,960 --> 00:35:32,880 AND THESE ARE VERY HIGH LEVEL 820 00:35:32,880 --> 00:35:36,040 AND VERY LIMITED IN SCOPE. 821 00:35:36,040 --> 00:35:41,200 OBVIOUSLY MANY HOURS COULD BE 822 00:35:41,200 --> 00:35:45,560 SPENT ON TALKING ABOUT THIS, BUT 823 00:35:45,560 --> 00:35:47,480 THE TIME ALLOTTED DOESN'T PERMIT 824 00:35:47,480 --> 00:35:47,640 IT. 825 00:35:47,640 --> 00:35:50,000 SO, WHAT I'D LIKE TO HIGHLIGHT 826 00:35:50,000 --> 00:35:53,120 AMONG THE MANY, MANY, MANY, MANY 827 00:35:53,120 --> 00:35:56,880 THINGS GOING ON EXTRAMURALLY, AT 828 00:35:56,880 --> 00:36:00,520 NIDCR, IS THE NIDCR ROLE IN NIH 829 00:36:00,520 --> 00:36:02,360 HEAL INITIATIVE, ADDRESSING THE 830 00:36:02,360 --> 00:36:03,760 OPIOID USE CRISIS IN THIS 831 00:36:03,760 --> 00:36:04,160 NATION. 832 00:36:04,160 --> 00:36:08,160 I'M SURE YOU ALL KNOW THAT WE 833 00:36:08,160 --> 00:36:12,200 HAVE A HORRIBLE PRICE TO PAY 834 00:36:12,200 --> 00:36:15,840 WITH THE OPIOID USE CRISIS WHICH 835 00:36:15,840 --> 00:36:17,560 HAS BEEN NOW EXACERBATED BOTH BY 836 00:36:17,560 --> 00:36:20,760 THE PANDEMIC AND BY THE INFLUX 837 00:36:20,760 --> 00:36:22,280 OF SYNTHETIC OPIOIDS LIKE 838 00:36:22,280 --> 00:36:25,680 FENTANYL WHICH ARE SO VERY, 839 00:36:25,680 --> 00:36:26,960 VERY, VERY DEADLY. 840 00:36:26,960 --> 00:36:28,720 NIDCR IS PLAYING AN IMPORTANT 841 00:36:28,720 --> 00:36:30,600 ROLE IN THIS. 842 00:36:30,600 --> 00:36:35,760 AS YOU CAN SEE, LOWER PORTION OF 843 00:36:35,760 --> 00:36:39,800 THE SLIDE, DR. D'SOUZA WORKED 844 00:36:39,800 --> 00:36:42,000 TOGETHER -- WORKS TOGETHER WITH 845 00:36:42,000 --> 00:36:43,280 DR. REBECCA BAKER, DIRECTOR OF 846 00:36:43,280 --> 00:36:46,800 THE HEAL INITIATIVE, AND THEY 847 00:36:46,800 --> 00:36:51,720 PARTICIPATED THROUGH A Q&A AND 848 00:36:51,720 --> 00:36:53,800 UNDERSCORING NIDCR'S COMMITMENT 849 00:36:53,800 --> 00:36:58,840 TO THIS VERY, VERY IMPORTANT 850 00:36:58,840 --> 00:36:59,120 INITIATIVE. 851 00:36:59,120 --> 00:37:04,840 AND AS YOU CAN SEE, THE OVERALL 852 00:37:04,840 --> 00:37:07,040 APPROACH IS TO BOTH IMPROVE 853 00:37:07,040 --> 00:37:10,760 PREVENTION AND TREATMENT FOR 854 00:37:10,760 --> 00:37:11,520 OPIOID MISUSE, OPIOID USE 855 00:37:11,520 --> 00:37:14,600 DISORDER, BUT ALSO TO COME UP 856 00:37:14,600 --> 00:37:17,520 WITH NEW WAYS OF ENHANCING PAIN 857 00:37:17,520 --> 00:37:21,120 MANAGEMENT WITHOUT THE USE OF 858 00:37:21,120 --> 00:37:22,840 OPIOIDS. 859 00:37:22,840 --> 00:37:24,640 SO, SPECIFICALLY, NIDCR IS 860 00:37:24,640 --> 00:37:27,480 ENGAGED IN TWO VERY IMPORTANT 861 00:37:27,480 --> 00:37:28,480 INITIATIVES. 862 00:37:28,480 --> 00:37:30,040 THE FIRST ON MYOFASCIAL PAIN. 863 00:37:30,040 --> 00:37:36,360 AND AS YOU CAN SEE, THIS IS 864 00:37:36,360 --> 00:37:40,200 BEING SUPPORTED BROADLY ACROSS 865 00:37:40,200 --> 00:37:40,520 NIH. 866 00:37:40,520 --> 00:37:44,040 BUT TO HIGHLIGHT THE FUNDING 867 00:37:44,040 --> 00:37:44,920 OPPORTUNITY ANNOUNCEMENT WILL 868 00:37:44,920 --> 00:37:48,520 INCREASE KNOWLEDGE ABOUT OTHER 869 00:37:48,520 --> 00:37:51,280 IMPORTANT PAIN CONDITIONS, 870 00:37:51,280 --> 00:37:52,520 INVOLVING MYOFASCIAL TISSUES 871 00:37:52,520 --> 00:37:54,200 INCLUDING TEMPOROMANDIBULAR 872 00:37:54,200 --> 00:37:55,000 DISORDERS AS WELL AS CHRONIC 873 00:37:55,000 --> 00:37:56,080 NECK AND SHOULDER PAIN AND 874 00:37:56,080 --> 00:37:57,040 HEADACHE. 875 00:37:57,040 --> 00:38:00,280 THIS IS A VERY IMPORTANT AREA, 876 00:38:00,280 --> 00:38:02,320 RIPE FOR DISCOVERY. 877 00:38:02,320 --> 00:38:04,080 AND WE'RE DELIGHTED THAT NIDCR 878 00:38:04,080 --> 00:38:07,920 IS TAKING LEADERSHIP IN THIS 879 00:38:07,920 --> 00:38:09,000 ASPECT. 880 00:38:09,000 --> 00:38:10,640 SIMILARLY, A HEAL INITIATIVE 881 00:38:10,640 --> 00:38:12,080 RESTORING JOINT HEALTH AND 882 00:38:12,080 --> 00:38:16,800 FUNCTION TO REDUCE PAIN, THIS IS 883 00:38:16,800 --> 00:38:22,040 A CONSORTIUM WHICH, AGAIN, IS 884 00:38:22,040 --> 00:38:23,480 PRIORITIZING BOTH 885 00:38:23,480 --> 00:38:24,280 TEMPOROMANDIBULAR JOINTS AND 886 00:38:24,280 --> 00:38:24,920 KNEE JOINTS. 887 00:38:24,920 --> 00:38:26,360 ONE OR BOTH OF THESE JOINTS NEED 888 00:38:26,360 --> 00:38:27,440 TO BE A FOCUS. 889 00:38:27,440 --> 00:38:33,320 THIS IS, AGAIN, AN INITIATIVE 890 00:38:33,320 --> 00:38:34,520 WHICH IS BEING DRIVEN BY A 891 00:38:34,520 --> 00:38:35,960 NUMBER OF INSTITUTES AND CENTERS 892 00:38:35,960 --> 00:38:38,320 BUT OF COURSE INCLUDING NIDCR. 893 00:38:38,320 --> 00:38:41,120 SO, I REALLY WANT TO THANK THE 894 00:38:41,120 --> 00:38:42,960 NIDCR STAFF WHO ENGAGED IN THESE 895 00:38:42,960 --> 00:38:46,920 AND OF COURSE DR. D'SOUZA FOR 896 00:38:46,920 --> 00:38:48,760 HER LEADERSHIP. 897 00:38:48,760 --> 00:38:50,120 SO, NOW, SIMILARLY I COULD GO ON 898 00:38:50,120 --> 00:38:55,880 AND ON AND ON AND ON ABOUT THE 899 00:38:55,880 --> 00:38:56,880 INTRAMURAL PROGRAM, AND AS I 900 00:38:56,880 --> 00:39:00,680 THINK YOU KNOW THERE ARE 26 901 00:39:00,680 --> 00:39:06,160 INVESTIGATOR LABS, FIVE RESEARCH 902 00:39:06,160 --> 00:39:09,480 FOCI, A VERY STRONG COMMITMENT 903 00:39:09,480 --> 00:39:16,120 WITH DR. D'SOUZA JOINING NIDCR 904 00:39:16,120 --> 00:39:18,760 ON TRANSLATION, THERE ARE SEVEN 905 00:39:18,760 --> 00:39:19,560 P.I.s. 906 00:39:19,560 --> 00:39:25,440 OF THE MANY EXAMPLES I COULD 907 00:39:25,440 --> 00:39:30,240 PICK FROM WITHIN THE INTRAMURAL 908 00:39:30,240 --> 00:39:32,360 PROGRAM THIS IS A PAPER, AN 909 00:39:32,360 --> 00:39:34,960 INVESTIGATOR IN THE INTRAMURAL 910 00:39:34,960 --> 00:39:37,280 PROGRAM, MARK HOON, HE'S 911 00:39:37,280 --> 00:39:38,680 INTERESTED IN ITCH. 912 00:39:38,680 --> 00:39:43,040 YOU MIGHT THINK, WELL, THAT'S AN 913 00:39:43,040 --> 00:39:45,480 ODD THING, BUT, YOU KNOW, WHAT 914 00:39:45,480 --> 00:39:48,520 MIGHT BE A NUISANCE FOR SOME 915 00:39:48,520 --> 00:39:51,560 DISEASES AND CONDITIONS SUCH AS 916 00:39:51,560 --> 00:39:53,600 PSORIASIS, ATOPIC DERMATITIS, 917 00:39:53,600 --> 00:40:02,440 THIS IS A VERY SIGNIFICANT 918 00:40:02,440 --> 00:40:02,800 ISSUE. 919 00:40:02,800 --> 00:40:12,640 AND WHAT TSENG AND HOON GOOD 920 00:40:12,640 --> 00:40:16,480 DEMONSTRATED, ONCOSTATIN M IS 921 00:40:16,480 --> 00:40:18,920 ABLE TO MODULATE THE ITCH 922 00:40:18,920 --> 00:40:23,280 RESPONSE AND SO IF YOU CAN 923 00:40:23,280 --> 00:40:26,400 AMELIORATE SIGNALING ON THE 924 00:40:26,400 --> 00:40:29,000 ONCOSTATIN PATHWAY YOU'RE 925 00:40:29,000 --> 00:40:31,640 ACTUALLY ABLE TO REDUCE THE NEED 926 00:40:31,640 --> 00:40:34,600 FOR ITCH, AND THEY HAVE 927 00:40:34,600 --> 00:40:35,800 CONSTRUCTED A MOUSE MODEL. 928 00:40:35,800 --> 00:40:40,120 AND AS YOU CAN SEE, BY REDUCING 929 00:40:40,120 --> 00:40:41,200 THE SIGNALING THAT'S IN THE 930 00:40:41,200 --> 00:40:43,240 LOWER CURVE IN THE RED, YOU CAN 931 00:40:43,240 --> 00:40:44,560 REDUCE THE AMOUNT OF ITCH. 932 00:40:44,560 --> 00:40:50,800 THIS IS GOING TO LEAD NO DOUBT 933 00:40:50,800 --> 00:40:52,880 TO THERAPEUTIC OPTIONS GOING 934 00:40:52,880 --> 00:41:00,200 FORWARD FOR SOME OF THESE VERY 935 00:41:00,200 --> 00:41:00,960 SEVERE DERMATOLOGICAL 936 00:41:00,960 --> 00:41:05,160 CONDITIONS. 937 00:41:05,160 --> 00:41:07,640 NEXT IS A BIT OF AN INDULGENCE 938 00:41:07,640 --> 00:41:09,960 SO PLEASE FORGIVE ME, BUT I'M 939 00:41:09,960 --> 00:41:11,600 SHOWING IT MORE TO HIGHLIGHT 940 00:41:11,600 --> 00:41:13,800 SOMETHING ABOUT THE INTRAMURAL 941 00:41:13,800 --> 00:41:17,840 PROGRAM. 942 00:41:17,840 --> 00:41:21,040 SO, THIS IS A COLLABORATION 943 00:41:21,040 --> 00:41:22,240 WHICH STARTED WITH OUR 944 00:41:22,240 --> 00:41:24,760 INTERESTS, WHEN I SAY OUR, I 945 00:41:24,760 --> 00:41:29,720 MEAN MY INTEREST, DR. KELLY TEN 946 00:41:29,720 --> 00:41:32,880 HAGEN AND DR. NADINE SAMARA'S 947 00:41:32,880 --> 00:41:33,840 INTEREST THOUSAND GLYCOPROTEINS 948 00:41:33,840 --> 00:41:36,720 ARE DECORATED WITH A CERTAIN 949 00:41:36,720 --> 00:41:41,080 CLASS OF SUGAR, O-GLYCANS, ALL 950 00:41:41,080 --> 00:41:46,440 ABOUT HOW YOU MAKE A PROPER 951 00:41:46,440 --> 00:41:47,600 MUCIN AND -- AND OTHER 952 00:41:47,600 --> 00:41:51,800 SECRETIONS COATING MUCOSAL 953 00:41:51,800 --> 00:41:52,920 SURFACES. 954 00:41:52,920 --> 00:41:53,560 CAN COLLEAGUES FROM UNIVERSITY 955 00:41:53,560 --> 00:41:59,480 MEDICAL CENTER IN THE 956 00:41:59,480 --> 00:42:06,800 NETHERLANDS, KELLY, NADINE AND I 957 00:42:06,800 --> 00:42:11,200 HAVE BEEN LOOKING AT HOW ONE OF 958 00:42:11,200 --> 00:42:13,160 THOSE ENZYMES THAT INITIATES 959 00:42:13,160 --> 00:42:15,000 O-GLYCOSYLATION ARE INVOLVED IN 960 00:42:15,000 --> 00:42:18,160 OVERALL ENERGY HOMEOSTASIS, SO 961 00:42:18,160 --> 00:42:22,160 TURNS OUT, CHART TO THE TOP 962 00:42:22,160 --> 00:42:26,640 LEFT, SHOWS THE ASSOCIATIONS 963 00:42:26,640 --> 00:42:32,640 BETWEEN GENE VARIANTS AND GALNT2 964 00:42:32,640 --> 00:42:35,680 GENE RELATED TOED ON POSITIVITY 965 00:42:35,680 --> 00:42:37,040 AND BMI IN HUMANS. 966 00:42:37,040 --> 00:42:42,080 AND IF YOU CAN MAKE OUT THE 967 00:42:42,080 --> 00:42:49,200 DATA, THIS IS ALL COMING OUT OF 968 00:42:49,200 --> 00:42:51,960 THE STUDY IN THE U.K., THE 969 00:42:51,960 --> 00:42:56,360 BIOBANK STUDY IN THE U.K., IN 970 00:42:56,360 --> 00:43:02,440 INDIVIDUALS WHO DO NOT HAVE A 971 00:43:02,440 --> 00:43:05,040 FULLY FUNCTIONAL GALNT2 YOU HAVE 972 00:43:05,040 --> 00:43:07,360 DECREASE IN LEG FAT PERCENTAGE, 973 00:43:07,360 --> 00:43:09,440 DECREASE IN BODY FAT PERCENTAGE, 974 00:43:09,440 --> 00:43:11,080 SO FORTH. 975 00:43:11,080 --> 00:43:13,120 A NULL MOUSE FOR THE SAME GENE 976 00:43:13,120 --> 00:43:17,320 CREATED IN MICE A NUMBER OF 977 00:43:17,320 --> 00:43:20,360 YEARS AGO, THESE MICE, WE SHOW 978 00:43:20,360 --> 00:43:24,640 EXAMPLES OF THIS, EXHIBIT 979 00:43:24,640 --> 00:43:26,400 SIMILAR DECREASED ADIPOSITY 980 00:43:26,400 --> 00:43:28,520 SIMILAR CHANGES IN THEIR BMI, IF 981 00:43:28,520 --> 00:43:30,320 YOU WILL. 982 00:43:30,320 --> 00:43:34,680 AND SO AS YOU DISSECT DOWN IN 983 00:43:34,680 --> 00:43:36,120 TERMS OF THE METABOLIC 984 00:43:36,120 --> 00:43:39,040 UNDERPINNINGS OF THIS, IT'S DUE 985 00:43:39,040 --> 00:43:41,680 TO INSULIN SIGNALING AND LOCAL 986 00:43:41,680 --> 00:43:45,360 EFFECTS APPEAR TO BE MEDIATED 987 00:43:45,360 --> 00:43:48,320 FOR INSULIN RECEPTOR 988 00:43:48,320 --> 00:43:48,760 GLYCOSYLATION. 989 00:43:48,760 --> 00:43:50,960 WHAT'S MOST REMARKABLE ABOUT 990 00:43:50,960 --> 00:43:52,880 THIS STUDY IS THAT IT'S BEEN 991 00:43:52,880 --> 00:43:59,320 GOING ON FOR ABOUT NINE YEARS, 992 00:43:59,320 --> 00:44:00,760 AND IT UNDERSCORES DIFFERENCE IN 993 00:44:00,760 --> 00:44:02,520 THE INTRAMURAL VERSUS EXTRAMURAL 994 00:44:02,520 --> 00:44:02,760 PROGRAM. 995 00:44:02,760 --> 00:44:04,160 THIS IS ONE OF THE ADVANTAGES OF 996 00:44:04,160 --> 00:44:06,120 THE INTRAMURAL PROGRAM IS YOU 997 00:44:06,120 --> 00:44:07,840 CAN SUSTAIN STUDIES OVER VERY, 998 00:44:07,840 --> 00:44:09,640 VERY LONG PERIOD OF TIME. 999 00:44:09,640 --> 00:44:11,280 IT TOOK TIME FOR SCIENCE TO 1000 00:44:11,280 --> 00:44:16,720 CATCH UP FOR US TO GET TO THIS 1001 00:44:16,720 --> 00:44:17,480 POINT. 1002 00:44:17,480 --> 00:44:19,560 CHRISTY FROM THE UMCG WAS THE 1003 00:44:19,560 --> 00:44:21,640 LEAD SHORE AND DID JUST A 1004 00:44:21,640 --> 00:44:23,080 REMARKABLE JOB. 1005 00:44:23,080 --> 00:44:25,160 SHE AND HER COLLEAGUES IN THE 1006 00:44:25,160 --> 00:44:26,680 NETHERLANDS SHOULD BE 1007 00:44:26,680 --> 00:44:28,680 CONGRATULATED, BUT ALSO GREAT 1008 00:44:28,680 --> 00:44:30,960 THANKS TO KELLY'S GROUP AND TO 1009 00:44:30,960 --> 00:44:34,000 NADINE'S GROUP AS WELL FOR ALL 1010 00:44:34,000 --> 00:44:35,240 OF THEIR CONTRIBUTIONS. 1011 00:44:35,240 --> 00:44:40,360 SO, NOW LET ME TURN TO THE TOPIC 1012 00:44:40,360 --> 00:44:42,280 OF DIVERSITY, EQUITY, AND 1013 00:44:42,280 --> 00:44:43,240 INCLUSION AND ACCESSIBILITY IN 1014 00:44:43,240 --> 00:44:45,480 THE ACTIVITIES. 1015 00:44:45,480 --> 00:44:52,280 I HAVE TO SAY THE TRAGIC 1016 00:44:52,280 --> 00:44:53,920 INCOMPREHENSIBLE EVENTS THAT 1017 00:44:53,920 --> 00:44:56,040 OCCURRED IN BUFFALO REALLY 1018 00:44:56,040 --> 00:45:00,600 UNDERSCORE THE NEED FOR NIH TO 1019 00:45:00,600 --> 00:45:04,400 REDOUBLE OUR EFFORTS IN THIS 1020 00:45:04,400 --> 00:45:04,600 SPACE. 1021 00:45:04,600 --> 00:45:06,960 SOME OF YOU KNOW I WAS AT THE 1022 00:45:06,960 --> 00:45:13,760 UNIVERSITY OF BUFFALO FOR NINE 1023 00:45:13,760 --> 00:45:14,640 YEARS, HOWEVER HORRIBLE THESE 1024 00:45:14,640 --> 00:45:16,600 TYPES OF EVENTS ARE AROUND THE 1025 00:45:16,600 --> 00:45:20,680 COUNTRY, WHEN IT OCCURS IN A 1026 00:45:20,680 --> 00:45:22,280 PLACE THAT YOU KNOW, IT HAS EVEN 1027 00:45:22,280 --> 00:45:25,480 A GREATER IMPACT. 1028 00:45:25,480 --> 00:45:31,880 IT'S REALLY QUITE REMARKABLE. 1029 00:45:31,880 --> 00:45:34,120 GOVERNMENT-WIDE, WE ARE WORKING 1030 00:45:34,120 --> 00:45:38,720 TO ADVANCE DEIA IN THE FEDERAL 1031 00:45:38,720 --> 00:45:41,800 WORKFORCE, IN RESPONSE TO OUR 1032 00:45:41,800 --> 00:45:44,480 NEED TO IMPLEMENT EXECUTIVE 1033 00:45:44,480 --> 00:45:45,800 ORDER 14035. 1034 00:45:45,800 --> 00:45:48,320 AND WE'VE RECEIVED REPORT 1035 00:45:48,320 --> 00:45:50,400 LANGUAGE, WHICH REQUIRES US TO 1036 00:45:50,400 --> 00:45:53,080 DEVELOP A STRATEGIC PLAN TO 1037 00:45:53,080 --> 00:45:54,360 INCLUDE SHORT- AND LONG-TERM 1038 00:45:54,360 --> 00:45:57,000 GOALS TO ADJUST RACIAL, ETHNIC, 1039 00:45:57,000 --> 00:45:58,520 GENDER DISPARITIES AT NIH AND 1040 00:45:58,520 --> 00:45:59,960 IDENTIFY AND ADDRESS BARRIERS IN 1041 00:45:59,960 --> 00:46:02,720 ACCESS TO NIH FUNDING BY 1042 00:46:02,720 --> 00:46:04,320 INVESTIGATORS WHO ARE STUDYING 1043 00:46:04,320 --> 00:46:05,440 HEALTH DISPARITIES. 1044 00:46:05,440 --> 00:46:07,720 WE ACTUALLY WERE WELL AHEAD OF 1045 00:46:07,720 --> 00:46:08,840 THIS EXECUTIVE ORDER, AND WELL 1046 00:46:08,840 --> 00:46:11,280 AHEAD OF THE REPORT LANGUAGE, 1047 00:46:11,280 --> 00:46:14,800 AND HAD BEEN DOING QUITE A BIT 1048 00:46:14,800 --> 00:46:16,680 OF WORK ALREADY. 1049 00:46:16,680 --> 00:46:22,960 THIS IS OUR FRAMEWORK FOR THE 1050 00:46:22,960 --> 00:46:24,680 OVERALL DEIA STRATEGIC PLAN. 1051 00:46:24,680 --> 00:46:29,480 THE OBJECTIVES ARE LISTED ON THE 1052 00:46:29,480 --> 00:46:29,880 LEFT. 1053 00:46:29,880 --> 00:46:31,480 AN INVENTORY ON THE RIGHT, WHICH 1054 00:46:31,480 --> 00:46:35,080 OF COURSE FEEDS IN TO OUR 1055 00:46:35,080 --> 00:46:38,120 ABILITY TO AMPLIFY UPON THE 1056 00:46:38,120 --> 00:46:41,160 FRAMEWORK, AND MUCH OF THE 1057 00:46:41,160 --> 00:46:44,560 INITIAL DATA WAS COLLECTED 1058 00:46:44,560 --> 00:46:46,280 THROUGH OUR UNITE INITIATIVE, IN 1059 00:46:46,280 --> 00:46:50,880 PARTICULAR THE U COMMITTEE, WITH 1060 00:46:50,880 --> 00:46:52,960 EDI'S EFFORTS FROM THE MD-715 1061 00:46:52,960 --> 00:46:53,520 REPORT. 1062 00:46:53,520 --> 00:46:56,800 THE UNITE INITIATIVE IS A 1063 00:46:56,800 --> 00:46:59,560 BOTTOM-UP EFFORT, FIVE WORK 1064 00:46:59,560 --> 00:47:02,280 STREAMS THAT ARE SUMMARIZED 1065 00:47:02,280 --> 00:47:03,680 HERE. 1066 00:47:03,680 --> 00:47:07,640 AND AS YOU CAN SEE, IT INCLUDES 1067 00:47:07,640 --> 00:47:08,880 LISTENING TO STAKEHOLDER 1068 00:47:08,880 --> 00:47:09,920 EXPERIENCE, DEVELOPING NEW 1069 00:47:09,920 --> 00:47:12,200 APPROACHES AND NEW OPPORTUNITIES 1070 00:47:12,200 --> 00:47:13,120 FOR RESEARCH IN HEALTH 1071 00:47:13,120 --> 00:47:14,640 DISPARITIES, MINORITY HEALTH AND 1072 00:47:14,640 --> 00:47:15,440 HEALTH EQUITY. 1073 00:47:15,440 --> 00:47:20,120 HOW CAN WE IMPROVE THE CULTURE 1074 00:47:20,120 --> 00:47:24,680 HERE AT NIH, HOW DO WE INCREASE 1075 00:47:24,680 --> 00:47:25,280 TRANSPARENCY, ACCOUNTABILITY, 1076 00:47:25,280 --> 00:47:27,120 ACROSS BOTH INTERNAL AND 1077 00:47:27,120 --> 00:47:27,800 EXTERNAL STAKEHOLDERS AND 1078 00:47:27,800 --> 00:47:31,600 FINALLY WHAT DO WE DO IN THE 1079 00:47:31,600 --> 00:47:32,800 EXTRAMURAL RESEARCH ECOSYSTEM. 1080 00:47:32,800 --> 00:47:36,280 THIS IS SOMETHING I'M VERY PROUD 1081 00:47:36,280 --> 00:47:39,280 OF TO HAVE HELPED INITIATE AND, 1082 00:47:39,280 --> 00:47:41,000 AGAIN, BOTTOM UP HUNDREDS OF 1083 00:47:41,000 --> 00:47:44,480 VOLUNTEERS ACROSS THE INSTITUTES 1084 00:47:44,480 --> 00:47:46,880 AND CENTERS, NIDCR OF COURSE 1085 00:47:46,880 --> 00:47:49,360 REPRESENTED IN THIS EFFORT. 1086 00:47:49,360 --> 00:47:55,720 DR. D'SOUZA IS HERSELF ON ONE OF 1087 00:47:55,720 --> 00:47:57,000 THE COMMITTEES. 1088 00:47:57,000 --> 00:48:02,720 SO THE SO-CALLED I COMMITTEE HAS 1089 00:48:02,720 --> 00:48:04,120 RELEASED REQUEST FOR 1090 00:48:04,120 --> 00:48:06,080 INFORMATION, AND THE IDEA IS TO 1091 00:48:06,080 --> 00:48:09,160 SEE IF WE SHOULD OFFER PRIZES 1092 00:48:09,160 --> 00:48:11,160 FOR INSTITUTIONAL EXCELLENCE IN 1093 00:48:11,160 --> 00:48:13,600 THIS SPACE TO ENABLE 1094 00:48:13,600 --> 00:48:16,400 ACKNOWLEDGMENT OF THESE EFFORTS. 1095 00:48:16,400 --> 00:48:19,120 WE ARE SEEKING BROAD INPUT. 1096 00:48:19,120 --> 00:48:25,200 THE RFI LINK IS DISPLAYED HERE. 1097 00:48:25,200 --> 00:48:28,000 RESPONSES ARE DUE BY JULY 28. 1098 00:48:28,000 --> 00:48:31,800 AND WE DO HOPE THAT PEOPLE WILL 1099 00:48:31,800 --> 00:48:34,160 ENGAGE IN THIS EFFORT AS WE TRY 1100 00:48:34,160 --> 00:48:39,000 AND COLLECT AS MANY GREAT IDEAS 1101 00:48:39,000 --> 00:48:41,400 AS POSSIBLE. 1102 00:48:41,400 --> 00:48:42,280 NOW, AGAIN, I WOULD NEED 1103 00:48:42,280 --> 00:48:45,000 TREMENDOUS AMOUNT OF TIME TO GO 1104 00:48:45,000 --> 00:48:47,160 THROUGH THE MANY, MANY EFFORTS 1105 00:48:47,160 --> 00:48:50,880 THE NIDCR IS DOING, BUT THESE 1106 00:48:50,880 --> 00:48:55,280 ARE JUST VERY HIGH LEVEL 1107 00:48:55,280 --> 00:49:00,560 EXAMPLES, NOT EXCLUSIVE BUT 1108 00:49:00,560 --> 00:49:02,000 ILLUSTRATIVE. 1109 00:49:02,000 --> 00:49:05,160 AWARDS TO ENHANCE DIVERSITY ARE 1110 00:49:05,160 --> 00:49:07,800 LISTED, A PARTNERSHIP WITH THE 1111 00:49:07,800 --> 00:49:12,840 AADR ON MENTORING AND INCLUSION, 1112 00:49:12,840 --> 00:49:18,680 AND THEN OF COURSE NIDCR HAS A 1113 00:49:18,680 --> 00:49:20,520 FORMALLY ESTABLISHED EQUITY, 1114 00:49:20,520 --> 00:49:21,920 DIVERSITY AND INCLUSION PLAN AS 1115 00:49:21,920 --> 00:49:22,880 A GUIDING PRINCIPLE IN 1116 00:49:22,880 --> 00:49:28,840 EVERYTHING THAT THEY DO. 1117 00:49:28,840 --> 00:49:29,560 ANTI-HARASSMENT, CONGRESS 1118 00:49:29,560 --> 00:49:35,600 STRENGTHENED OUR ABILITY TO 1119 00:49:35,600 --> 00:49:38,560 ADDRESS HARASSMENT THROUGH 1120 00:49:38,560 --> 00:49:39,560 CONSOLIDATED ACT, AND UNIVERSE 1121 00:49:39,560 --> 00:49:40,360 FER UNIVERSITIES ARE OBLIGATED 1122 00:49:40,360 --> 00:49:42,280 TO TELL US IF PEOPLE HAVE BEEN 1123 00:49:42,280 --> 00:49:45,240 IDENTIFIED EITHER THOSE WHO ARE 1124 00:49:45,240 --> 00:49:46,440 P.I.s OR KEY PERSONNEL, IF 1125 00:49:46,440 --> 00:49:48,640 THEY HAVE BEEN REMOVED FROM 1126 00:49:48,640 --> 00:49:51,480 POSITIONS OR DISCIPLINED DUE TO 1127 00:49:51,480 --> 00:49:55,080 HARASSMENT, BULLYING, 1128 00:49:55,080 --> 00:49:56,560 RETALIATION, HOSTILE WORKING 1129 00:49:56,560 --> 00:49:57,520 CONDITIONS, AND SO THIS IS 1130 00:49:57,520 --> 00:49:59,000 SOMETHING THAT WE'VE BEEN 1131 00:49:59,000 --> 00:50:00,760 WORKING HARD AT OVER THE LAST 1132 00:50:00,760 --> 00:50:05,160 FIVE YEARS TO ENSURE SAFE 1133 00:50:05,160 --> 00:50:08,320 WORKPLACE BUT NOW THIS IS NO 1134 00:50:08,320 --> 00:50:11,840 LONGER A NEGOTIATION WITH 1135 00:50:11,840 --> 00:50:12,880 INSTITUTIONS, APPLICANT 1136 00:50:12,880 --> 00:50:13,240 ORGANIZATIONS. 1137 00:50:13,240 --> 00:50:15,040 THIS IS NOW A REQUIREMENT OF THE 1138 00:50:15,040 --> 00:50:15,200 LAW. 1139 00:50:15,200 --> 00:50:18,960 AND SO WE NOW HAVE THE AUTHORITY 1140 00:50:18,960 --> 00:50:21,280 TO REQUIRE INSTITUTIONS TO 1141 00:50:21,280 --> 00:50:22,760 REPORT HARASSMENT-RELATED 1142 00:50:22,760 --> 00:50:24,120 PERSONNEL CHANGES ON GRANTS. 1143 00:50:24,120 --> 00:50:25,880 WE'RE VERY GRATEFUL TO THE 1144 00:50:25,880 --> 00:50:27,400 CONGRESS FOR PROVIDING US WITH 1145 00:50:27,400 --> 00:50:31,840 THIS ADDITIONAL SET OF TOOLS. 1146 00:50:31,840 --> 00:50:35,720 AND FINALLY, TO SAY A LITTLE BIT 1147 00:50:35,720 --> 00:50:37,760 ABOUT ARPA-H, THE ADVANCED 1148 00:50:37,760 --> 00:50:44,240 RESEARCH PROJECTS AGENCY FOR 1149 00:50:44,240 --> 00:50:45,560 HELP, THE OMNIBUS APPROPRIATED 1150 00:50:45,560 --> 00:50:49,720 $1 BILLION TO ESTABLISH THIS NEW 1151 00:50:49,720 --> 00:50:50,360 ENTITY WITHIN THE DEPARTMENT OF 1152 00:50:50,360 --> 00:50:52,640 HEALTH AND HUMAN SERVICES. 1153 00:50:52,640 --> 00:50:54,080 THE SECRETARY TRANSFERRED ARPA-H 1154 00:50:54,080 --> 00:50:55,720 TO NIH. 1155 00:50:55,720 --> 00:50:59,880 AND THE FUNDS TO NIH. 1156 00:50:59,880 --> 00:51:01,720 BUT DETERMINED THAT THE 1157 00:51:01,720 --> 00:51:03,160 INDIVIDUAL WHO IS ULTIMATELY 1158 00:51:03,160 --> 00:51:05,720 REPORTED AS INAUGURAL DIRECTOR 1159 00:51:05,720 --> 00:51:07,240 OF ARPA-H WILL REPORT TO THE 1160 00:51:07,240 --> 00:51:07,520 SECRETARY. 1161 00:51:07,520 --> 00:51:11,080 THIS WILL BE A PRESIDENTIAL 1162 00:51:11,080 --> 00:51:11,360 APPOINTEE. 1163 00:51:11,360 --> 00:51:13,760 AND THIS INDIVIDUAL WILL HAVE 1164 00:51:13,760 --> 00:51:19,200 FULL AUTHORITY FOR ALL THE 1165 00:51:19,200 --> 00:51:22,240 ADMINISTRATION AND OPERATIONS. 1166 00:51:22,240 --> 00:51:23,680 THE SECRETARY AND I THINK 1167 00:51:23,680 --> 00:51:27,080 INTERIM DIRECTOR IS PROBABLY NOT 1168 00:51:27,080 --> 00:51:29,280 ACCURATE, BUT WILL LIKELY BE 1169 00:51:29,280 --> 00:51:32,240 REPORTED SOME OPERATIONAL STAFF 1170 00:51:32,240 --> 00:51:34,920 TO HELP US PROVIDE 1171 00:51:34,920 --> 00:51:36,040 ADMINISTRATIVE AND OPERATIONAL 1172 00:51:36,040 --> 00:51:40,960 SUPPORT AS WE SORT OF BUILD THE 1173 00:51:40,960 --> 00:51:43,480 WIRING AND SO FORTH, 1174 00:51:43,480 --> 00:51:44,560 ADMINISTRATIVELY, AWAITING THE 1175 00:51:44,560 --> 00:51:46,280 INAUGURAL DIRECTOR WHICH, AGAIN, 1176 00:51:46,280 --> 00:51:47,840 IS A PRESIDENTIAL APPOINTMENT. 1177 00:51:47,840 --> 00:51:49,920 TODAY THE ENERGY AND COMMERCE 1178 00:51:49,920 --> 00:51:53,200 COMMITTEE MARKS UP ITS BILL, 1179 00:51:53,200 --> 00:51:55,720 WHICH AT LEAST FROM INITIAL WORD 1180 00:51:55,720 --> 00:52:00,760 THAT I'VE RECEIVED MAY SEEK TO 1181 00:52:00,760 --> 00:52:04,600 MOVE ARPA-H OUTSIDE OF NIH BACK 1182 00:52:04,600 --> 00:52:06,480 INTO HHS, SO STAY TUNED. 1183 00:52:06,480 --> 00:52:08,280 WE'LL HAVE TO WAIT TO SEE HOW 1184 00:52:08,280 --> 00:52:09,560 THIS ALL PLAYS OUT. 1185 00:52:09,560 --> 00:52:12,280 REGARDLESS OF HOW IT PLAYS OUT, 1186 00:52:12,280 --> 00:52:15,360 NIH STANDS READY TO PROVIDE 1187 00:52:15,360 --> 00:52:17,400 WHATEVER EFFORT WE CAN TO HELP 1188 00:52:17,400 --> 00:52:19,840 STAND UP THE ORGANIZATION 1189 00:52:19,840 --> 00:52:20,760 ADMINISTRATIVELY, FROM A 1190 00:52:20,760 --> 00:52:21,680 PRACTICAL STANDPOINT WE WANT TO 1191 00:52:21,680 --> 00:52:24,760 BE ABLE TO USE ALL THE EQUITIES 1192 00:52:24,760 --> 00:52:28,840 WE HAVE AVAILABLE TO ENSURE A 1193 00:52:28,840 --> 00:52:30,640 RAPID AND SUCCESSFUL STANDUP OF 1194 00:52:30,640 --> 00:52:31,960 THIS NEW AGENCY. 1195 00:52:31,960 --> 00:52:41,080 WITH THAT, AND WITH APOLOGIES 1196 00:52:41,080 --> 00:52:42,720 FOR RACING THROUGH, I THANK YOU 1197 00:52:42,720 --> 00:52:43,360 FOR LISTENING. 1198 00:52:43,360 --> 00:52:45,040 I'LL STOP SHARING MY SLIDES, I 1199 00:52:45,040 --> 00:52:45,240 HOPE. 1200 00:52:45,240 --> 00:52:47,640 OF COURSE IF THERE ARE COMMENTS 1201 00:52:47,640 --> 00:52:49,800 OR QUESTIONS I'D BE DELIGHTED TO 1202 00:52:49,800 --> 00:52:51,800 ANSWER THOSE. 1203 00:52:51,800 --> 00:52:53,440 SO THANK YOU. 1204 00:52:53,440 --> 00:52:53,640 OKAY. 1205 00:52:53,640 --> 00:52:56,600 I ASSUME I'VE STOPPED SHARING MY 1206 00:52:56,600 --> 00:52:57,320 SLIDES, RIGHT? 1207 00:52:57,320 --> 00:52:57,800 OKAY, GOOD. 1208 00:52:57,800 --> 00:53:00,280 >> THANK YOU VERY MUCH, LARRY, 1209 00:53:00,280 --> 00:53:01,760 FOR THE GREAT OVERVIEW. 1210 00:53:01,760 --> 00:53:06,240 I OPEN THE FLOOR FOR ANY 1211 00:53:06,240 --> 00:53:07,840 QUESTIONS FROM COUNCIL AND 1212 00:53:07,840 --> 00:53:10,080 NIDCR. 1213 00:53:10,080 --> 00:53:12,280 1214 00:53:12,280 --> 00:53:14,320 I DON'T SEE ANYTHING IN THE 1215 00:53:14,320 --> 00:53:14,920 THAT'S PRESSING. 1216 00:53:14,920 --> 00:53:19,480 THERE MAY BE SOME FROM OUR -- 1217 00:53:19,480 --> 00:53:20,480 >> I'VE ANESTHETIZED EVERYBODY. 1218 00:53:20,480 --> 00:53:27,040 I WASN'T SO GOOD AT THIS WHEN I 1219 00:53:27,040 --> 00:53:28,680 WAS PRACTICING. 1220 00:53:28,680 --> 00:53:30,560 >> I'VE ALREADY DESCRIBED YOUR 1221 00:53:30,560 --> 00:53:31,840 BIO, AS LIVING VICARIOUSLY 1222 00:53:31,840 --> 00:53:33,280 THROUGH YOUR MUSICAL SON AND 1223 00:53:33,280 --> 00:53:36,640 YOU'VE BECOME A FANTASTIC 1224 00:53:36,640 --> 00:53:37,760 STANDUP COMIC, WE LOOK FORWARD 1225 00:53:37,760 --> 00:53:38,640 TO BEING ENTERTAINED. 1226 00:53:38,640 --> 00:53:44,240 >> I WAS A STANDUP COMIC LONG 1227 00:53:44,240 --> 00:53:46,200 BEFORE THIS. 1228 00:53:46,200 --> 00:53:48,040 >> ANY QUESTIONS FROM THE 1229 00:53:48,040 --> 00:53:48,320 AUDIENCE? 1230 00:53:48,320 --> 00:53:49,280 OBVIOUSLY WHAT I'VE HEARD MOST 1231 00:53:49,280 --> 00:53:50,880 OFTEN IS WHAT ABOUT THE NEW 1232 00:53:50,880 --> 00:53:51,280 DIRECTOR. 1233 00:53:51,280 --> 00:53:53,120 I KNOW THERE ARE RUMORS FLOATING 1234 00:53:53,120 --> 00:53:53,960 AROUND, LARRY. 1235 00:53:53,960 --> 00:53:58,200 >> THE NEW DIRECTOR? 1236 00:53:58,200 --> 00:54:00,400 OH, YES, THAT. 1237 00:54:00,400 --> 00:54:01,400 THANKS, RENA. 1238 00:54:01,400 --> 00:54:05,040 OF COURSE, AS YOU KNOW, THIS IS 1239 00:54:05,040 --> 00:54:07,040 A SENATE CONFIRMED PRESIDENTIAL 1240 00:54:07,040 --> 00:54:08,760 APPOINTEE, THE WAY IT WORKS IS 1241 00:54:08,760 --> 00:54:12,440 THE PRESIDENT WILL NEED TO 1242 00:54:12,440 --> 00:54:14,480 ANNOUNCE HIS CHOICE OF NOMINEE 1243 00:54:14,480 --> 00:54:18,280 FOR THE NEXT PERMANENT DIRECTOR 1244 00:54:18,280 --> 00:54:19,440 OF NIH. 1245 00:54:19,440 --> 00:54:22,280 THAT NOMINATION GOES TO THE 1246 00:54:22,280 --> 00:54:25,280 SENATE FOR THEIR CONSIDERATION. 1247 00:54:25,280 --> 00:54:27,720 THE NOMINEE WILL HAVE TO MEET 1248 00:54:27,720 --> 00:54:30,680 WITH MEMBERS OF THE SUBCOMMITTEE 1249 00:54:30,680 --> 00:54:33,040 THAT WILL REPORT OUT ON THE 1250 00:54:33,040 --> 00:54:33,360 NOMINATION. 1251 00:54:33,360 --> 00:54:36,880 AND THEN ULTIMATELY IT GOES TO 1252 00:54:36,880 --> 00:54:41,160 THE FULL SENATE. 1253 00:54:41,160 --> 00:54:45,960 THE CALCULUS OF COURSE IS THAT 1254 00:54:45,960 --> 00:54:50,440 THE CONGRESS DOES GO INTO RECESS 1255 00:54:50,440 --> 00:54:51,880 TOWARDS EARLY AUGUST. 1256 00:54:51,880 --> 00:54:55,240 AND WHEN THEY RETURN IN THE 1257 00:54:55,240 --> 00:55:00,200 FALL, AS YOU KNOW, THIS IS AN 1258 00:55:00,200 --> 00:55:01,080 ELECTION YEAR. 1259 00:55:01,080 --> 00:55:03,280 AND SO THE HOPE OF COURSE IS 1260 00:55:03,280 --> 00:55:08,800 THAT THEY WILL HAVE A NOMINEE 1261 00:55:08,800 --> 00:55:11,240 CONFIRMED BEFORE RECESS OCCURS. 1262 00:55:11,240 --> 00:55:13,560 BUT AS OF THIS MORNING WE DO NOT 1263 00:55:13,560 --> 00:55:15,160 YET HAVE A NOMINEE, AND BY THE 1264 00:55:15,160 --> 00:55:17,480 WAY, AS FAR AS MY INSIGHT, I 1265 00:55:17,480 --> 00:55:18,920 WILL READ ABOUT IT IN THE 1266 00:55:18,920 --> 00:55:21,000 "WASHINGTON POST" ALONG WITH 1267 00:55:21,000 --> 00:55:21,800 EVERYBODY ELSE. 1268 00:55:21,800 --> 00:55:25,520 SO BECAUSE AS THE ACTING 1269 00:55:25,520 --> 00:55:29,440 DIRECTOR, I'M ACTUALLY REMOVED 1270 00:55:29,440 --> 00:55:32,920 FROM ANY OF THE, YOU KNOW, 1271 00:55:32,920 --> 00:55:34,440 ENGAGEMENT IN THIS. 1272 00:55:34,440 --> 00:55:39,600 AND, YOU KNOW, APPROPRIATELY SO. 1273 00:55:39,600 --> 00:55:42,120 SO, WE'LL SEE WHAT THE TIMING 1274 00:55:42,120 --> 00:55:42,360 IS. 1275 00:55:42,360 --> 00:55:44,280 IN THE MEANTIME, AS I TRY TO 1276 00:55:44,280 --> 00:55:47,040 REASSURE BOTH THE HOUSE AND THE 1277 00:55:47,040 --> 00:55:49,440 SENATE, AS THE ACTING DIRECTOR 1278 00:55:49,440 --> 00:55:50,880 WE'RE MOVING FORWARD ON THE 1279 00:55:50,880 --> 00:55:53,840 MANY, MANY THINGS THAT NIH NEEDS 1280 00:55:53,840 --> 00:55:55,160 TO DO. 1281 00:55:55,160 --> 00:56:01,840 AND AMONG THOSE THINGS IS WE'RE 1282 00:56:01,840 --> 00:56:02,520 PREPARING MATERIALS, MUCH 1283 00:56:02,520 --> 00:56:05,120 CONDENSED FROM WHAT THEY USED TO 1284 00:56:05,120 --> 00:56:06,920 BE, BUT MATERIALS FOR ANY 1285 00:56:06,920 --> 00:56:07,840 TRANSITION THAT WILL OCCUR. 1286 00:56:07,840 --> 00:56:11,680 SO THAT WE CAN GET THE NEW 1287 00:56:11,680 --> 00:56:14,840 PERMANENT NIH DIRECTOR UP AND 1288 00:56:14,840 --> 00:56:17,160 RUNNING AS RAPIDLY AS POSSIBLE. 1289 00:56:17,160 --> 00:56:21,120 WHEN YOU SEE STUFF IN THE 1290 00:56:21,120 --> 00:56:24,120 NEWSPAPER, THAT'S WHAT IT IS. 1291 00:56:24,120 --> 00:56:24,880 IT'S STUFF. 1292 00:56:24,880 --> 00:56:29,840 AND THERE'S REALLY NO WAY OF 1293 00:56:29,840 --> 00:56:31,080 KNOWING WHETHER IT'S TRUE AND 1294 00:56:31,080 --> 00:56:32,480 TRIAL BALLOONS ARE BEING FLOATED 1295 00:56:32,480 --> 00:56:34,360 OR IF IT'S FALSE AND PEOPLE ARE 1296 00:56:34,360 --> 00:56:36,920 JUST MAKING THINGS UP. 1297 00:56:36,920 --> 00:56:40,560 OR EVERYTHING IN BETWEEN. 1298 00:56:40,560 --> 00:56:42,000 THE OLD WISDOM OF WASHINGTON IS 1299 00:56:42,000 --> 00:56:43,400 IF SOMEBODY TELLS YOU THEY KNOW 1300 00:56:43,400 --> 00:56:44,360 SOMETHING, THEY DON'T. 1301 00:56:44,360 --> 00:56:46,080 IF SOMEBODY TELLS YOU THEY DON'T 1302 00:56:46,080 --> 00:56:49,000 KNOW SOMETHING, THEY DO. 1303 00:56:49,000 --> 00:56:50,520 SO THERE YOU GO. 1304 00:56:50,520 --> 00:56:51,320 >> ABSOLUTELY. 1305 00:56:51,320 --> 00:56:53,600 LARRY, I DO HAVE AN OVERARCHING 1306 00:56:53,600 --> 00:56:56,600 QUESTION, AND I KNOW THAT YOU 1307 00:56:56,600 --> 00:56:57,760 WOULD HAVE SOMEBODY WISE TO 1308 00:56:57,760 --> 00:57:00,280 INFORM US ABOUT. 1309 00:57:00,280 --> 00:57:02,480 YOU KNOW, WE AT NIDCR ARE CAUGHT 1310 00:57:02,480 --> 00:57:04,080 IN A VIRTUAL CYCLE WHERE WE PAY 1311 00:57:04,080 --> 00:57:06,080 ATTENTION TO TRENDS IN OUR 1312 00:57:06,080 --> 00:57:08,040 EDUCATIONAL SECTOR AS WELL AS 1313 00:57:08,040 --> 00:57:10,240 OUR PRACTICING FRONTS, AND YOU 1314 00:57:10,240 --> 00:57:11,920 KNOW WHAT THOSE ARE WELL 1315 00:57:11,920 --> 00:57:14,200 REFLECTED IN THE REPORT ON ORAL 1316 00:57:14,200 --> 00:57:16,640 HEALTH STATUS OF AMERICA. 1317 00:57:16,640 --> 00:57:18,160 AS I TRAVEL AROUND, I'VE GAUGED 1318 00:57:18,160 --> 00:57:19,960 THERE ARE SCHOOLS THAT 1319 00:57:19,960 --> 00:57:21,280 EXPERIENCED GREAT DIFFICULTY 1320 00:57:21,280 --> 00:57:24,240 BECAUSE OF REVENUE STREAMS BEING 1321 00:57:24,240 --> 00:57:26,800 NARROWED THROUGH THE PANDEMIC. 1322 00:57:26,800 --> 00:57:29,040 ADMINISTRATIVE PRIORITIES, NEW 1323 00:57:29,040 --> 00:57:31,040 SCHOOLS POPPING UP, NOW 70 ON 1324 00:57:31,040 --> 00:57:33,560 THE MAP, MANY BEING PROPRIETARY 1325 00:57:33,560 --> 00:57:34,080 SCHOOLS. 1326 00:57:34,080 --> 00:57:38,840 WHAT ADVICE WOULD YOU GIVE US AT 1327 00:57:38,840 --> 00:57:39,800 NIDCR BOTH, FOR KNOWLEDGE 1328 00:57:39,800 --> 00:57:42,080 CREATION AND TAKE IT SERIOUSLY, 1329 00:57:42,080 --> 00:57:44,080 WHAT COULD YOU INFORM US ABOUT 1330 00:57:44,080 --> 00:57:47,680 AS WE FACE THESE CHALLENGES? 1331 00:57:47,680 --> 00:57:52,480 >> WELL, THEY ARE INDEED 1332 00:57:52,480 --> 00:57:56,760 CHALLENGES, RENA. 1333 00:57:56,760 --> 00:58:00,560 NIDCR UNDERGIRDS THE PROFESSION 1334 00:58:00,560 --> 00:58:03,800 OF DENTISTRY, AND SO IT IS 1335 00:58:03,800 --> 00:58:05,640 INCUMBENT UPON NIDCR AND NIH AS 1336 00:58:05,640 --> 00:58:13,400 A WHOLE OF COURSE TO BE 1337 00:58:13,400 --> 00:58:15,520 SUPPORTIVE OF ANY PROFESSIONAL 1338 00:58:15,520 --> 00:58:17,720 SCHOOL IN DENTISTRY. 1339 00:58:17,720 --> 00:58:22,920 THE HOPE BEING THAT ALL THESE 1340 00:58:22,920 --> 00:58:25,440 SCHOOLS WILL FIND THEIR NICHE 1341 00:58:25,440 --> 00:58:30,160 AND WILL SUPPORT SCHOLARLY 1342 00:58:30,160 --> 00:58:30,480 ACTIVITY. 1343 00:58:30,480 --> 00:58:32,440 ABSENT THAT, AND I'VE LIKENED 1344 00:58:32,440 --> 00:58:34,960 THE PROFESSION OF DENTISTRY AND 1345 00:58:34,960 --> 00:58:37,240 THE TRIALS AND TRIBULATIONS TO 1346 00:58:37,240 --> 00:58:39,040 EYE CARE, SO FORGIVE ME, I'LL GO 1347 00:58:39,040 --> 00:58:40,440 THROUGH THAT FOR A MOMENT. 1348 00:58:40,440 --> 00:58:45,480 YOU KNOW, WE LIKE TO THINK OF 1349 00:58:45,480 --> 00:58:50,400 OURSELVES AS OPHTHALMOLOGISTS, 1350 00:58:50,400 --> 00:58:53,480 PHYSICIANS OF THE MOUTHS. 1351 00:58:53,480 --> 00:58:58,160 MANY ARE MORE LIKE OPTOMETRISTS, 1352 00:58:58,160 --> 00:59:00,680 YOU KNOW, DELIVERING 1353 00:59:00,680 --> 00:59:02,760 HIGH-QUALITY CARE, BUT NOT AT 1354 00:59:02,760 --> 00:59:06,040 THE LEVEL OF, YOU KNOW, THE 1355 00:59:06,040 --> 00:59:06,720 OPHTHALMOLOGIST, SAY. 1356 00:59:06,720 --> 00:59:10,080 IF WE'RE NOT CAREFUL WE'RE GOING 1357 00:59:10,080 --> 00:59:12,480 TO BECOME OPTICIANS. 1358 00:59:12,480 --> 00:59:14,680 AND I FEAR THAT SOME, NOT ALL, 1359 00:59:14,680 --> 00:59:19,320 BUT SOME OF THESE SO-CALLED 1360 00:59:19,320 --> 00:59:20,280 NEWER PROPRIETARY SCHOOLS FALL 1361 00:59:20,280 --> 00:59:28,160 OR COULD FALL IN THAT BUCKET. 1362 00:59:28,160 --> 00:59:32,760 TO BE A PROFESSION, YOU NEED 1363 00:59:32,760 --> 00:59:36,400 STRONG INQUIRY. 1364 00:59:36,400 --> 00:59:37,600 YOU NEED STRONG EXPLORATION. 1365 00:59:37,600 --> 00:59:40,200 AND THAT CAN COME IN MANY, MANY, 1366 00:59:40,200 --> 00:59:41,160 MANY FORMS. 1367 00:59:41,160 --> 00:59:44,640 YOU CAN MAKE KNOCKOUT MICE OR 1368 00:59:44,640 --> 00:59:48,400 YOU CAN DO SURVEYS OF PROVIDER 1369 00:59:48,400 --> 00:59:48,720 EXPERIENCE. 1370 00:59:48,720 --> 00:59:51,120 I MEAN, EVERYTHING IN BETWEEN. 1371 00:59:51,120 --> 00:59:54,200 BUT YOU'VE GOT TO ENGAGE IN 1372 00:59:54,200 --> 00:59:55,200 SCHOLARLY ACTIVITY. 1373 00:59:55,200 --> 00:59:58,840 AND I -- AND SO THE CHALLENGE, 1374 00:59:58,840 --> 01:00:01,480 RENA, AND THE CHALLENGE TO ALL 1375 01:00:01,480 --> 01:00:02,880 OF MY COLLEAGUES AT NIDCR, AND 1376 01:00:02,880 --> 01:00:11,320 TO ALL OF YOU ON THE COUNCIL, IS 1377 01:00:11,320 --> 01:00:16,560 MAKE AVAILABLE THE OPPORTUNITIES 1378 01:00:16,560 --> 01:00:18,440 THAT ALL SCHOOLS OF DENTISTRY 1379 01:00:18,440 --> 01:00:21,760 ARE ABLE TO EMBRACE BECAUSE 1380 01:00:21,760 --> 01:00:27,080 SHUNNING THEM WON'T WORK. 1381 01:00:27,080 --> 01:00:31,920 AND BUT ENABLING WON'T EITHER. 1382 01:00:31,920 --> 01:00:36,480 SO I THINK WE'VE GOT TO STRIKE 1383 01:00:36,480 --> 01:00:38,560 THAT BALANCE. 1384 01:00:38,560 --> 01:00:40,400 AND I HOPE THAT, YOU KNOW, IF 1385 01:00:40,400 --> 01:00:43,160 I'VE UPSET SOME FOLKS OUT THERE, 1386 01:00:43,160 --> 01:00:45,440 YOU KNOW, WHO ARE INVOLVED WITH 1387 01:00:45,440 --> 01:00:47,320 SOME OF THESE SO-CALLED 1388 01:00:47,320 --> 01:00:48,920 PROPRIETARY SCHOOLS, IT'S A 1389 01:00:48,920 --> 01:00:52,440 WAKEUP CALL TO YOU. 1390 01:00:52,440 --> 01:00:53,000 HONESTLY. 1391 01:00:53,000 --> 01:00:55,520 AND SO I DO HOPE YOU WILL FIND A 1392 01:00:55,520 --> 01:00:57,480 WAY FOR YOUR FACULTY AND FIND A 1393 01:00:57,480 --> 01:01:00,880 WAY FOR YOUR STUDENTS TO ENGAGE 1394 01:01:00,880 --> 01:01:02,280 IN SCHOLARLY INQUIRY. 1395 01:01:02,280 --> 01:01:04,360 YOU KNOW, AT WHATEVER LEVEL IT 1396 01:01:04,360 --> 01:01:05,040 IS. 1397 01:01:05,040 --> 01:01:07,960 >> WE DO HAVE OPPORTUNITIES 1398 01:01:07,960 --> 01:01:10,800 COMING FORTH AND THERE IS A HAND 1399 01:01:10,800 --> 01:01:11,040 RAISED. 1400 01:01:11,040 --> 01:01:11,240 RAUL? 1401 01:01:11,240 --> 01:01:13,000 >> THANK YOU VERY MUCH, DR. 1402 01:01:13,000 --> 01:01:13,440 TABAK. 1403 01:01:13,440 --> 01:01:15,000 IMPRESSIVE TO SEE THE PROGRESS 1404 01:01:15,000 --> 01:01:17,920 THAT THE NIH OVERALL HAS MADE, 1405 01:01:17,920 --> 01:01:19,880 OF COURSE THE NIDCR IN THE AREA 1406 01:01:19,880 --> 01:01:21,520 OF DIVERSITY AND KUDOS TO YOU 1407 01:01:21,520 --> 01:01:22,040 ALL ON THAT. 1408 01:01:22,040 --> 01:01:24,240 I HAVE A SPECIFIC QUESTION IN 1409 01:01:24,240 --> 01:01:25,240 THAT REGARD. 1410 01:01:25,240 --> 01:01:35,680 DO YOU NOT THINK THE 2019 NEEDS 1411 01:01:35,680 --> 01:01:37,720 TO BE UPDATED? 1412 01:01:37,720 --> 01:01:41,360 THE 2019 NIH NOTICE MAKES NO 1413 01:01:41,360 --> 01:01:42,760 MENTION, SILENT ON THE LGBTQ 1414 01:01:42,760 --> 01:01:44,080 COMMUNITY IN REGARDS TO 1415 01:01:44,080 --> 01:01:45,600 DIVERSITY AND WOULD IT NOT BE 1416 01:01:45,600 --> 01:01:48,360 TIMELY FOR THE NIH TO TAKE THAT 1417 01:01:48,360 --> 01:01:49,120 ON? 1418 01:01:49,120 --> 01:01:52,640 >> YEAH, THANK YOU. 1419 01:01:52,640 --> 01:01:57,920 YEAH, WE'VE BEEN DISCUSSING THE 1420 01:01:57,920 --> 01:01:58,680 TIMING. 1421 01:01:58,680 --> 01:02:04,000 LGBTQI GROUPS OF COURSE ARE PART 1422 01:02:04,000 --> 01:02:05,560 OF THE DIVERSITY GROUP THAT 1423 01:02:05,560 --> 01:02:11,480 NIMHD AND THE REST OF NIH 1424 01:02:11,480 --> 01:02:13,200 RECOGNIZES, APPROPRIATELY SO. 1425 01:02:13,200 --> 01:02:17,240 AND AS YOU MAY KNOW, AS PART OF 1426 01:02:17,240 --> 01:02:21,440 THIS YEAR'S PRESIDENTIAL BUDGET, 1427 01:02:21,440 --> 01:02:25,160 WE'VE REQUESTED RESOURCES FOR A 1428 01:02:25,160 --> 01:02:27,200 SMALL CENTER WITHIN THE OFFICE 1429 01:02:27,200 --> 01:02:30,400 OF THE DIRECTOR, AND THE SEXUAL 1430 01:02:30,400 --> 01:02:32,920 AND GENDER MINORITY RESEARCH 1431 01:02:32,920 --> 01:02:34,680 OFFICE TO SPECIFICALLY ENHANCE 1432 01:02:34,680 --> 01:02:36,880 OUR ABILITY AND THE RESEARCH 1433 01:02:36,880 --> 01:02:43,440 COMMUNITY TO TAKE ADVANTAGE OF 1434 01:02:43,440 --> 01:02:46,400 THE RECENT REPORT ON DESCRIPTORS 1435 01:02:46,400 --> 01:02:50,480 AND SO FORTH IN THIS SPACE, AND 1436 01:02:50,480 --> 01:02:52,400 YOU'RE CORRECT FOR POINTING THAT 1437 01:02:52,400 --> 01:02:52,960 OUT. 1438 01:02:52,960 --> 01:02:55,160 THAT IS ONE ADDITIONAL THING WE 1439 01:02:55,160 --> 01:02:58,560 COULD ADD, SO I APPRECIATE THAT 1440 01:02:58,560 --> 01:03:00,040 YOU MENTIONED THAT. 1441 01:03:00,040 --> 01:03:01,640 >> THANKS, LARRY. 1442 01:03:01,640 --> 01:03:02,920 AND ANOTHER HAND UP. 1443 01:03:02,920 --> 01:03:05,640 >> YES, THANKS FOR A GREAT 1444 01:03:05,640 --> 01:03:05,920 OVERVIEW. 1445 01:03:05,920 --> 01:03:08,840 MY COMMENT OR QUESTION HAS TO DO 1446 01:03:08,840 --> 01:03:09,400 WITH COVID. 1447 01:03:09,400 --> 01:03:11,120 SO WHAT WE SEE AND WHAT YOU'VE 1448 01:03:11,120 --> 01:03:15,000 SHOWN US IS THAT THERE ARE THESE 1449 01:03:15,000 --> 01:03:16,520 NEW IMMUNOMODULATORY AGENTS THAT 1450 01:03:16,520 --> 01:03:18,920 HAVEN'T BEEN USED PREVIOUSLY IN 1451 01:03:18,920 --> 01:03:21,560 THE CONTEXT OF VIRAL INFECTIONS, 1452 01:03:21,560 --> 01:03:23,400 WE'RE SEEING REALLY A NEW 1453 01:03:23,400 --> 01:03:25,720 MEANING OF WHAT SYSTEMIC 1454 01:03:25,720 --> 01:03:27,480 DISEASES OR SYSTEMIC ILLNESS IS 1455 01:03:27,480 --> 01:03:32,040 IN THE CONTEXT OF COVID. 1456 01:03:32,040 --> 01:03:34,040 >> I'VE LOST HER. 1457 01:03:34,040 --> 01:03:39,720 HAVE I LOST YOU ALL? 1458 01:03:39,720 --> 01:03:40,320 NO? 1459 01:03:40,320 --> 01:03:40,520 >> NO. 1460 01:03:40,520 --> 01:03:41,960 >> BUT I LOST JENNIFER. 1461 01:03:41,960 --> 01:03:43,880 I'VE LOST RENA. 1462 01:03:43,880 --> 01:03:46,400 OH MY. 1463 01:03:46,400 --> 01:03:48,120 1464 01:03:48,120 --> 01:03:50,240 THEY MUST BE IN BUILDING 31. 1465 01:03:50,240 --> 01:03:51,640 AH, THEY DIDN'T PAY THE BILL. 1466 01:03:51,640 --> 01:03:56,560 THAT'S WHAT IT IS, OKAY. 1467 01:03:56,560 --> 01:03:58,200 >> BUILDING 30 IS STILL WORKING. 1468 01:03:58,200 --> 01:04:00,280 >> AS IS BUILDING 1, LET THE 1469 01:04:00,280 --> 01:04:00,800 RECORD SHOW. 1470 01:04:00,800 --> 01:04:01,520 [LAUGHTER] 1471 01:04:01,520 --> 01:04:02,280 OH MY. 1472 01:04:02,280 --> 01:04:08,080 WELL, I'M NOT QUITE SURE WHAT 1473 01:04:08,080 --> 01:04:10,440 JENNIFER HAD TO SAY. 1474 01:04:10,440 --> 01:04:12,040 >> HOPEFULLY WE'LL BE ABLE TO 1475 01:04:12,040 --> 01:04:12,400 REJOIN. 1476 01:04:12,400 --> 01:04:13,640 >> I'M SURE THEY ARE FRANTICALLY 1477 01:04:13,640 --> 01:04:15,400 TRYING TO GET THIS THING SET 1478 01:04:15,400 --> 01:04:18,360 BACK UP AGAIN. 1479 01:04:18,360 --> 01:04:20,560 WE'VE LOST JENNIFER AND RENA. 1480 01:04:20,560 --> 01:04:23,160 I'LL HANG OUT UNTIL THEY SHOW 1481 01:04:23,160 --> 01:04:23,360 UP. 1482 01:04:23,360 --> 01:04:26,360 >> DOES ANYBODY ELSE HAVE A 1483 01:04:26,360 --> 01:04:28,560 QUESTION FOR DR. TABAK WHILE 1484 01:04:28,560 --> 01:04:29,280 WE'RE WAITING? 1485 01:04:29,280 --> 01:04:31,840 NICE TO SEE YOU, LARRY. 1486 01:04:31,840 --> 01:04:35,000 >> YEAH. 1487 01:04:35,000 --> 01:04:36,720 >> WELL, I WAS REMISS. 1488 01:04:36,720 --> 01:04:39,360 IT IS REALLY NICE TO SEE A 1489 01:04:39,360 --> 01:04:40,320 NUMBER OF COLLEAGUES THAT I 1490 01:04:40,320 --> 01:04:42,200 HAVEN'T SEEN IN A WHILE. 1491 01:04:42,200 --> 01:04:45,600 GOOD TO SEE YOU ALL. 1492 01:04:45,600 --> 01:04:49,640 1493 01:04:49,640 --> 01:04:52,280 >> I DON'T SEE -- 1494 01:04:52,280 --> 01:04:54,320 >> LARRY, TELL US MORE ABOUT 1495 01:04:54,320 --> 01:04:54,760 ARPA-H. 1496 01:04:54,760 --> 01:04:56,720 YOU HAD IT ON YOUR SLIDE BUT I 1497 01:04:56,720 --> 01:04:58,120 THINK IT'S SOMETHING THAT MANY 1498 01:04:58,120 --> 01:05:00,040 WANT TO HEAR ABOUT. 1499 01:05:00,040 --> 01:05:00,320 >> YEAH. 1500 01:05:00,320 --> 01:05:05,200 SO, THIS IS PATTERNED AFTER 1501 01:05:05,200 --> 01:05:07,600 DARPA, WHICH HAS ONLY ONE 1502 01:05:07,600 --> 01:05:10,360 CLIENT, THE DEFENSE DEPARTMENT. 1503 01:05:10,360 --> 01:05:16,040 AND THEY HAVE HAD A SERIES OF 1504 01:05:16,040 --> 01:05:16,800 SUCCESSES INCLUDING THE 1505 01:05:16,800 --> 01:05:19,840 INTERNET, AT LEAST WHAT BECAME 1506 01:05:19,840 --> 01:05:21,080 THE INTERNET. 1507 01:05:21,080 --> 01:05:25,880 AND IT'S A DIFFERENT WAY OF 1508 01:05:25,880 --> 01:05:26,360 IDENTIFYING SCIENTIFIC 1509 01:05:26,360 --> 01:05:28,960 OPPORTUNITIES AND IT IS A 1510 01:05:28,960 --> 01:05:34,040 DIFFERENT WAY OF SUPPORTING 1511 01:05:34,040 --> 01:05:35,880 THOSE SCIENTIFIC OPPORTUNITIES. 1512 01:05:35,880 --> 01:05:40,360 IT'S MUCH MORE GOAL ORIENTED, 1513 01:05:40,360 --> 01:05:41,800 MUCH MORE DELIVERY OF A 1514 01:05:41,800 --> 01:05:47,440 PLATFORM. 1515 01:05:47,440 --> 01:05:49,960 DELIVERY OF A PRODUCT. 1516 01:05:49,960 --> 01:05:52,840 DOESN'T DO A LOT OF BASIC 1517 01:05:52,840 --> 01:05:55,000 SCIENCE UNLESS BASIC SCIENCE 1518 01:05:55,000 --> 01:05:56,440 NEEDS TO BE INVENTED. 1519 01:05:56,440 --> 01:05:58,280 I DON'T MEAN TO BE HYPERBOLIC. 1520 01:05:58,280 --> 01:06:00,240 I MEANS IT TAKES ON VERY, VERY, 1521 01:06:00,240 --> 01:06:01,920 VERY HIGH RISK EFFORTS SO YOU 1522 01:06:01,920 --> 01:06:03,720 NEED TO DEVELOP NEW MATH TO 1523 01:06:03,720 --> 01:06:04,720 FIGURE SOMETHING OUT, YOU 1524 01:06:04,720 --> 01:06:10,600 DEVELOP THE NEW MATH. 1525 01:06:10,600 --> 01:06:11,600 AND SO FORTH. 1526 01:06:11,600 --> 01:06:15,000 BASED UPON THE DARPA MODEL FOR 1527 01:06:15,000 --> 01:06:18,280 DEFENSE AND IARPA, WHICH IS USED 1528 01:06:18,280 --> 01:06:22,640 IN THE INTELLIGENCE COMMUNITY, 1529 01:06:22,640 --> 01:06:28,840 AND ARPA-E IN THE ENERGY FIELD 1530 01:06:28,840 --> 01:06:30,040 THE ADMINISTRATION FELT STRONGLY 1531 01:06:30,040 --> 01:06:34,720 THAT HEALTH COULD ALSO USE THIS 1532 01:06:34,720 --> 01:06:35,320 APPROACH. 1533 01:06:35,320 --> 01:06:37,560 THE APPROACH IS VERY DIFFERENT 1534 01:06:37,560 --> 01:06:41,360 THAN NIH'S. 1535 01:06:41,360 --> 01:06:43,440 THE DIRECTOR OF THE ORGANIZATION 1536 01:06:43,440 --> 01:06:46,840 RECRUITS A SERIES OF PROJECT 1537 01:06:46,840 --> 01:06:48,680 MANAGERS, WHO ARE HIRED ON THE 1538 01:06:48,680 --> 01:06:51,640 BASIS OF THE IDEAS THEY BRING TO 1539 01:06:51,640 --> 01:06:56,120 THE TABLE ABOUT NEW THINGS, NEW 1540 01:06:56,120 --> 01:06:57,320 EXCITING RISKY THINGS. 1541 01:06:57,320 --> 01:07:00,840 THE PROGRAM, THESE PROJECT 1542 01:07:00,840 --> 01:07:03,120 MANAGERS ARE EMPOWERED TO MAKE 1543 01:07:03,120 --> 01:07:08,120 MANY DECISIONS IN TERMS OF WHO 1544 01:07:08,120 --> 01:07:08,680 IS SUPPORTED. 1545 01:07:08,680 --> 01:07:11,800 WE DO NOT -- THEY DO NOT USE THE 1546 01:07:11,800 --> 01:07:15,000 PEER REVIEW SYSTEM, THE REVIEW 1547 01:07:15,000 --> 01:07:19,680 IS DONE INTERNALLY BY FEDERAL 1548 01:07:19,680 --> 01:07:20,040 EMPLOYEES. 1549 01:07:20,040 --> 01:07:25,480 THERE ARE VERY STRICT 1550 01:07:25,480 --> 01:07:26,600 MILESTONE-DRIVEN ACTIVITIES, AND 1551 01:07:26,600 --> 01:07:29,800 YOU FAIL EARLY AND RAPIDLY. 1552 01:07:29,800 --> 01:07:34,040 SO YOU WOULD NOT BE DOING A 1553 01:07:34,040 --> 01:07:36,480 NINE-YEAR PROJECT IS THE ONE I 1554 01:07:36,480 --> 01:07:37,880 DESCRIBED KELLY, NADINE AND MY 1555 01:07:37,880 --> 01:07:42,400 GROUP AND THE GROUP IN THE 1556 01:07:42,400 --> 01:07:42,720 NETHERLAND. 1557 01:07:42,720 --> 01:07:43,320 YOU FAIL QUICKLY. 1558 01:07:43,320 --> 01:07:44,600 IF IT'S NOT GOING TO GO, IT'S 1559 01:07:44,600 --> 01:07:45,760 NOT GOING TO GO. 1560 01:07:45,760 --> 01:07:48,400 THE CLOSEST WE HAVE TO THIS AT 1561 01:07:48,400 --> 01:07:50,240 NIH IS OUR USE OF OTHER 1562 01:07:50,240 --> 01:07:51,440 TRANSACTION AUTHORITIES WHICH 1563 01:07:51,440 --> 01:07:52,520 SOME INSTITUTES AND CENTERS USE 1564 01:07:52,520 --> 01:07:58,360 AND WE USE IN THE OFFICE OF THE 1565 01:07:58,360 --> 01:07:59,120 DIRECTOR. 1566 01:07:59,120 --> 01:08:02,720 BUT NOT USING TRADITIONAL PEER 1567 01:08:02,720 --> 01:08:05,640 REVIEW SYSTEM, BEING ABLE TO MIX 1568 01:08:05,640 --> 01:08:07,000 AND MATCH YOUR RESEARCH TEAM. 1569 01:08:07,000 --> 01:08:09,480 SO IF YOU PUT OUT AN 1570 01:08:09,480 --> 01:08:10,880 ANNOUNCEMENT FOR -- I'M MAKING 1571 01:08:10,880 --> 01:08:14,520 IT UP NOW, TISSUE ENGINEERING OF 1572 01:08:14,520 --> 01:08:17,520 THE CRANIOFACIAL COMPLEX, AND 1573 01:08:17,520 --> 01:08:21,760 YOU GET IN TEN APPLICATIONS, 1574 01:08:21,760 --> 01:08:23,280 YOU'LL LIKE WHAT MATT HOFFMAN IS 1575 01:08:23,280 --> 01:08:24,720 DOING IN THE FIRST APPLICATION, 1576 01:08:24,720 --> 01:08:27,200 YOU LIKE WHAT RAUL GARCIA IS 1577 01:08:27,200 --> 01:08:28,960 DOING IN THE SECOND, ET CETERA. 1578 01:08:28,960 --> 01:08:33,120 AND YOU MIX AND MATCH THE TEAM. 1579 01:08:33,120 --> 01:08:34,840 AND YOU'RE NOT OBLIGATED TO TAKE 1580 01:08:34,840 --> 01:08:37,400 ANY TEAM INTACT BUT YOU BUILD 1581 01:08:37,400 --> 01:08:37,920 YOUR OWN TEAM. 1582 01:08:37,920 --> 01:08:44,480 AND SO IT IS A VERY, VERY 1583 01:08:44,480 --> 01:08:47,880 DIFFERENT APPROACH TO SOLVING 1584 01:08:47,880 --> 01:08:49,280 PROBLEMS BASICALLY. 1585 01:08:49,280 --> 01:08:51,600 NOW, THE ORGANIZATION IS TO 1586 01:08:51,600 --> 01:08:55,200 SOLVE PROBLEMS FOR MOLECULES TO 1587 01:08:55,200 --> 01:08:55,560 SOCIETAL. 1588 01:08:55,560 --> 01:08:56,760 WHICH IS A HEAVY LIFT. 1589 01:08:56,760 --> 01:09:05,040 AND EQUITY HAS TO BE BUILT INTO 1590 01:09:05,040 --> 01:09:05,960 EVERYTHING THEY DO. 1591 01:09:05,960 --> 01:09:08,240 IF YOU MAKE SOME APPROACH WHICH 1592 01:09:08,240 --> 01:09:10,480 NOBODY CAN AFFORD, THEN WE'VE 1593 01:09:10,480 --> 01:09:12,240 LOST THE BATTLE. 1594 01:09:12,240 --> 01:09:16,040 WE'VE NOT ACCOMPLISHED ANYTHING. 1595 01:09:16,040 --> 01:09:18,680 AND SO IT'S A COMPLETELY NEW WAY 1596 01:09:18,680 --> 01:09:21,080 OF LOOKING AT THINGS, AND MANY 1597 01:09:21,080 --> 01:09:25,800 FEEL THAT THIS WOULD BE AN 1598 01:09:25,800 --> 01:09:28,400 OUTSTANDING ADDITION TO WHAT 1599 01:09:28,400 --> 01:09:32,160 NIH -- WHAT THE NIH APPROACH IS, 1600 01:09:32,160 --> 01:09:36,280 WHICH OBVIOUSLY USES TRADITIONAL 1601 01:09:36,280 --> 01:09:37,520 PEER REVIEW, IS THERE MORE FOR 1602 01:09:37,520 --> 01:09:40,040 THE LONG TERM, SUPPORTS THE 1603 01:09:40,040 --> 01:09:42,760 BASIC SCIENCE, MUCH OF WHICH 1604 01:09:42,760 --> 01:09:45,680 THEN ORGANIZATIONS LIKE DARPA 1605 01:09:45,680 --> 01:09:48,000 TURN INTO DELIVERABLES AND SO 1606 01:09:48,000 --> 01:09:48,480 FORTH. 1607 01:09:48,480 --> 01:09:52,440 SO I SEE JENNIFER HAS REJOINED. 1608 01:09:52,440 --> 01:09:54,360 WE'RE TALKING ABOUT ARPA-H. 1609 01:09:54,360 --> 01:09:56,560 I HOPE EVERYTHING HAS BEEN 1610 01:09:56,560 --> 01:09:58,400 PLUGGED BACK IN. 1611 01:09:58,400 --> 01:09:59,920 I DON'T SEE RENA YET. 1612 01:09:59,920 --> 01:10:03,120 >> WE HAVE NO INTERNET HERE AT 1613 01:10:03,120 --> 01:10:03,720 NIDCR. 1614 01:10:03,720 --> 01:10:05,120 I'M ON THE PHONE. 1615 01:10:05,120 --> 01:10:05,640 >> OKAY. 1616 01:10:05,640 --> 01:10:07,880 >> BUT HOPING TO GET BACK ON. 1617 01:10:07,880 --> 01:10:10,040 >> ALL RIGHT. 1618 01:10:10,040 --> 01:10:11,520 >> SORRY FOR THE DISRUPTION. 1619 01:10:11,520 --> 01:10:17,840 WE DO HAVE SOME TIME FOR 1620 01:10:17,840 --> 01:10:18,440 JENNIFER'S QUESTION. 1621 01:10:18,440 --> 01:10:20,720 >> DID YOU HEAR THE END OF THE 1622 01:10:20,720 --> 01:10:21,000 QUESTION? 1623 01:10:21,000 --> 01:10:22,080 >> NO, UNFORTUNATELY NOT, 1624 01:10:22,080 --> 01:10:23,280 JENNIFER. 1625 01:10:23,280 --> 01:10:26,000 I HEARD THE FACT THAT BY 1626 01:10:26,000 --> 01:10:28,080 EXPLORING THE USE OF IMMUNE 1627 01:10:28,080 --> 01:10:29,400 MODULATORS AND VIRAL DISEASE 1628 01:10:29,400 --> 01:10:33,240 WE'VE ENTERED AND THEN YOU CUT 1629 01:10:33,240 --> 01:10:33,640 OFF. 1630 01:10:33,640 --> 01:10:35,200 >> WELL, SO LEARNED SO MUCH, 1631 01:10:35,200 --> 01:10:35,560 RIGHT? 1632 01:10:35,560 --> 01:10:38,160 WE'VE GOT IN ADDITION TO USING 1633 01:10:38,160 --> 01:10:39,040 IMMUNOMODULATORS WHICH WE'VE NOT 1634 01:10:39,040 --> 01:10:41,680 USED BEFORE WE'VE GOT A NEW 1635 01:10:41,680 --> 01:10:42,880 DEFINITION WHAT SYSTEMIC ILLNESS 1636 01:10:42,880 --> 01:10:45,600 IS IN THE CONTEXT OF THIS LONG 1637 01:10:45,600 --> 01:10:46,040 COVID. 1638 01:10:46,040 --> 01:10:47,600 AND WE'RE DOING SCIENCE A 1639 01:10:47,600 --> 01:10:48,560 DIFFERENT WAY. 1640 01:10:48,560 --> 01:10:50,200 WHAT DO YOU THINK THIS MEANS FOR 1641 01:10:50,200 --> 01:10:53,960 THE WAY THAT WE SHOULD APPROACH 1642 01:10:53,960 --> 01:10:55,680 SCIENCE HERE AT NIDCR? 1643 01:10:55,680 --> 01:10:58,280 AND ACROSS OUR DIFFERENT 1644 01:10:58,280 --> 01:10:58,680 LABORATORIES. 1645 01:10:58,680 --> 01:11:03,600 >> YEAH, WELL, ACROSS AND AMONG 1646 01:11:03,600 --> 01:11:05,640 ARE THE KEY STATEMENTS. 1647 01:11:05,640 --> 01:11:14,040 SCIENCE IS A TEAM SPORT. 1648 01:11:14,040 --> 01:11:16,120 AND HONESTLY, I THOROUGHLY 1649 01:11:16,120 --> 01:11:17,920 APPRECIATE THE CREATIVITY OF 1650 01:11:17,920 --> 01:11:19,000 INDIVIDUAL SCIENTISTS. 1651 01:11:19,000 --> 01:11:21,280 BUT WHEN YOU GET TWO AND THREE 1652 01:11:21,280 --> 01:11:25,200 AND FIVE CREATIVE SCIENTISTS 1653 01:11:25,200 --> 01:11:28,400 TOGETHER, IT'S EVEN THAT MUCH 1654 01:11:28,400 --> 01:11:28,640 BETTER. 1655 01:11:28,640 --> 01:11:33,680 EVERYTHING WE KNOW ABOUT TEAMS, 1656 01:11:33,680 --> 01:11:34,840 SCIENCE OF TEAMS, UNDERSCORES 1657 01:11:34,840 --> 01:11:36,280 THE FACT DIVERSE TEAMS DO BETTER 1658 01:11:36,280 --> 01:11:36,560 WORK. 1659 01:11:36,560 --> 01:11:38,320 I DON'T KNOW WHY ANYBODY IS 1660 01:11:38,320 --> 01:11:39,760 SURPRISED BY THAT, BUT IT'S BEEN 1661 01:11:39,760 --> 01:11:43,040 PROVEN OVER AND OVER AGAIN. 1662 01:11:43,040 --> 01:11:46,000 AND SO AS A FUNDING AGENCY, WE 1663 01:11:46,000 --> 01:11:51,240 HAVE TO DO A BETTER JOB OF 1664 01:11:51,240 --> 01:11:54,840 ENABLING PEOPLE TO TEAM, 1665 01:11:54,840 --> 01:11:57,920 ENABLING PEOPLE TO FIND EACH 1666 01:11:57,920 --> 01:12:03,640 OTHER, BECAUSE THAT'S OFTEN THE 1667 01:12:03,640 --> 01:12:05,280 BIGGEST CHALLENGE IS KNOWING 1668 01:12:05,280 --> 01:12:06,120 THAT THERE'S SOMEBODY ON THE 1669 01:12:06,120 --> 01:12:08,800 OTHER SIDE OF THE CAMPUS OR IN 1670 01:12:08,800 --> 01:12:10,080 ANOTHER STATE OR ANOTHER COUNTRY 1671 01:12:10,080 --> 01:12:11,920 THAT IS DOING SOMETHING THAT 1672 01:12:11,920 --> 01:12:14,040 WOULD BE SO VERY COMPLEMENTARY 1673 01:12:14,040 --> 01:12:17,120 TO WHAT YOU'RE TRYING TO DO. 1674 01:12:17,120 --> 01:12:21,680 SO, I WOULD HOPE GOING FORWARD, 1675 01:12:21,680 --> 01:12:24,000 YOU KNOW, WE EMPOWER NEWER 1676 01:12:24,000 --> 01:12:25,840 INVESTIGATORS SOONER, FIGURE OUT 1677 01:12:25,840 --> 01:12:34,320 HOW TO ENCOURAGE MORE TEAMING, 1678 01:12:34,320 --> 01:12:43,600 NOT LESS, AND FRANKLY, YOU KNOW, 1679 01:12:43,600 --> 01:12:46,320 REALLY INCENTIVIZE THIS NOTION 1680 01:12:46,320 --> 01:12:50,600 THAT THE WHOLE GROUP SHOULD BE 1681 01:12:50,600 --> 01:12:51,160 REWARDED. 1682 01:12:51,160 --> 01:12:55,320 IT'S STILL THE CASE I FEAR THAT 1683 01:12:55,320 --> 01:12:56,600 ACADEMIC ORGANIZATIONS INCLUDING 1684 01:12:56,600 --> 01:12:58,160 THE NIH INTRAMURAL PROGRAM, 1685 01:12:58,160 --> 01:13:00,640 QUITE FRANKLY, SO I'M NOT SAYING 1686 01:13:00,640 --> 01:13:04,400 THAT NIH HAS SOLVED THIS YET. 1687 01:13:04,400 --> 01:13:05,600 YOU KNOW, IF YOU'RE THE FIRST 1688 01:13:05,600 --> 01:13:06,200 AUTHOR, GREAT. 1689 01:13:06,200 --> 01:13:08,320 IF YOU'RE THE LAST AUTHOR, 1690 01:13:08,320 --> 01:13:08,840 GREAT. 1691 01:13:08,840 --> 01:13:11,680 IF YOU'RE SOMEWHERE IN BETWEEN, 1692 01:13:11,680 --> 01:13:13,880 STILL MANY AN ACADEMIC 1693 01:13:13,880 --> 01:13:15,320 ORGANIZATION, INCLUDING NIH, YOU 1694 01:13:15,320 --> 01:13:16,640 KNOW, SORT OF QUESTION, WELL, 1695 01:13:16,640 --> 01:13:18,280 WHAT DOES THAT MEAN IN TERMS OF 1696 01:13:18,280 --> 01:13:18,920 YOUR CONTRIBUTION? 1697 01:13:18,920 --> 01:13:22,640 WE'VE GOT TO GET OVER THAT. 1698 01:13:22,640 --> 01:13:28,840 FOR SCIENCE TO MOVE FORWARD THE 1699 01:13:28,840 --> 01:13:33,680 ET AL. NEED TO BE RECOGNIZED FOR 1700 01:13:33,680 --> 01:13:36,400 THE VALUE OF WHAT THEY ARE 1701 01:13:36,400 --> 01:13:36,720 DOING. 1702 01:13:36,720 --> 01:13:38,680 OFTEN, I'M SURE MANY OF YOU HAVE 1703 01:13:38,680 --> 01:13:40,640 THIS EXPERIENCE, IT'S THE 1704 01:13:40,640 --> 01:13:43,720 CLINICIAN SCIENTIST IN THE 1705 01:13:43,720 --> 01:13:46,160 MIDDLE, AND THEY SORT OF GET 1706 01:13:46,160 --> 01:13:50,520 SHORT CHANGED IN THE CREDIT BUT 1707 01:13:50,520 --> 01:13:53,560 WITHOUT THEIR INSIGHT, WITHOUT 1708 01:13:53,560 --> 01:13:55,640 THEIR UNDERSTANDING OF THE 1709 01:13:55,640 --> 01:13:57,560 CLINICAL NUANCES OF WHAT IS 1710 01:13:57,560 --> 01:14:00,480 BEING DEALT WITH, THE WORK 1711 01:14:00,480 --> 01:14:01,360 DOESN'T HAPPEN. 1712 01:14:01,360 --> 01:14:03,320 SO, ALL GLORY TO THE FIRST 1713 01:14:03,320 --> 01:14:05,760 AUTHOR, ALL GLORY TO THE 1714 01:14:05,760 --> 01:14:07,680 SO-CALLED SENIOR AUTHOR IN 1715 01:14:07,680 --> 01:14:08,800 BIOMEDICAL RESEARCH, BUT WE'VE 1716 01:14:08,800 --> 01:14:12,320 GOT TO FIGURE OUT A BETTER 1717 01:14:12,320 --> 01:14:12,960 REWARD SYSTEM BECAUSE AT THE END 1718 01:14:12,960 --> 01:14:16,560 OF THE DAY THAT'S WHAT DRIVES SO 1719 01:14:16,560 --> 01:14:19,000 MUCH OF THIS. 1720 01:14:19,000 --> 01:14:21,840 AND SO I HOPE NIDCR WILL DO 1721 01:14:21,840 --> 01:14:22,920 EXPERIMENTS IN THIS SPACE, NIH 1722 01:14:22,920 --> 01:14:26,120 AS A WHOLE IS DOING EXPERIMENTS 1723 01:14:26,120 --> 01:14:27,640 IN THIS SPACE. 1724 01:14:27,640 --> 01:14:30,600 BUT I THINK THAT'S WHAT THE 1725 01:14:30,600 --> 01:14:31,760 PANDEMIC HAS TAUGHT US IS IT'S 1726 01:14:31,760 --> 01:14:34,800 GOT TO BE A TEAM SPORT. 1727 01:14:34,800 --> 01:14:37,000 IT REALLY DOES. 1728 01:14:37,000 --> 01:14:38,280 >> A MAJOR CULTURE SHIFT. 1729 01:14:38,280 --> 01:14:39,880 BUT AN IMPORTANT ONE. 1730 01:14:39,880 --> 01:14:41,640 >> NO QUESTION. 1731 01:14:41,640 --> 01:14:43,280 AND I KNOW MATT, YOU WORK HARD 1732 01:14:43,280 --> 01:14:48,000 AT THIS IN THE INTRAMURAL 1733 01:14:48,000 --> 01:14:48,320 PROGRAM. 1734 01:14:48,320 --> 01:14:50,200 I MEAN, I STAY PERIPHERAL 1735 01:14:50,200 --> 01:14:53,480 BECAUSE I HAVE THIS DAY JOB, BUT 1736 01:14:53,480 --> 01:14:56,080 I SEE IT IN MY TRAINEES, I SEE 1737 01:14:56,080 --> 01:14:59,720 IT IN THE FOLKS IN MY OWN LITTLE 1738 01:14:59,720 --> 01:15:00,160 GROUP. 1739 01:15:00,160 --> 01:15:01,480 THIS IS SOMETHING THAT MATT 1740 01:15:01,480 --> 01:15:03,760 DRIVES VERY HARD. 1741 01:15:03,760 --> 01:15:05,600 AND I KNOW JANICE DRIVES VERY 1742 01:15:05,600 --> 01:15:07,160 HARD IN THE CLINICAL SIDE, 1743 01:15:07,160 --> 01:15:09,000 CLINICAL CENTER. 1744 01:15:09,000 --> 01:15:12,640 I KNOW THE NIDCR LEADERSHIP IS 1745 01:15:12,640 --> 01:15:16,440 DEEPLY ENGAGED IN THIS APPROACH. 1746 01:15:16,440 --> 01:15:17,440 1747 01:15:17,440 --> 01:15:20,840 WELL, I'M GOING TO HAVE TO JUMP 1748 01:15:20,840 --> 01:15:21,000 OFF. 1749 01:15:21,000 --> 01:15:25,560 I HOPE YOU FIND A WAY FOR RENA 1750 01:15:25,560 --> 01:15:27,280 TO JOIN. 1751 01:15:27,280 --> 01:15:28,720 >> THANK YOU VERY, VERY MUCH, 1752 01:15:28,720 --> 01:15:29,720 DR. TABAK. 1753 01:15:29,720 --> 01:15:31,080 >> I REALLY APPRECIATE BEING 1754 01:15:31,080 --> 01:15:32,440 ABLE TO BE HERE. 1755 01:15:32,440 --> 01:15:33,720 AND HOPE THE REST OF YOUR 1756 01:15:33,720 --> 01:15:37,640 COUNCIL GOES A LITTLE BIT MORE 1757 01:15:37,640 --> 01:15:37,920 SMOOTHLY. 1758 01:15:37,920 --> 01:15:39,960 BUT REALLY NICE. 1759 01:15:39,960 --> 01:15:44,400 AND I WILL DO ONE ADDITIONAL, AS 1760 01:15:44,400 --> 01:15:49,040 I'M LEAVING, ONE ADDITIONAL IRP 1761 01:15:49,040 --> 01:15:49,600 ADVERTISEMENT. 1762 01:15:49,600 --> 01:15:51,440 WHEN I WAS ORIGINALLY ASKED TO 1763 01:15:51,440 --> 01:15:53,360 DO THIS, I THOUGHT, GREAT, I'M 1764 01:15:53,360 --> 01:15:54,600 GOING TO TALK ABOUT NIKI 1765 01:15:54,600 --> 01:15:57,240 MOUTSOPOULOS'S WORK. 1766 01:15:57,240 --> 01:15:58,440 AND THEN I LEARNED SHE'S GOING 1767 01:15:58,440 --> 01:16:01,840 TO BE SPEAKING. 1768 01:16:01,840 --> 01:16:03,120 INSTEAD OF ME BUTCHERING HER 1769 01:16:03,120 --> 01:16:04,960 ELEGANT WORK YOU GET TO HEAR IT 1770 01:16:04,960 --> 01:16:06,320 DIRECTLY FROM NIKI. 1771 01:16:06,320 --> 01:16:07,840 I HOPE YOU ENJOY IT BECAUSE IT'S 1772 01:16:07,840 --> 01:16:08,720 REALLY GREAT. 1773 01:16:08,720 --> 01:16:09,360 THANKS, EVERYBODY. 1774 01:16:09,360 --> 01:16:11,120 >> THANKS, LARRY. 1775 01:16:11,120 --> 01:16:12,080 >> TAKE CARE. 1776 01:16:12,080 --> 01:16:13,560 >> THANK YOU. 1777 01:16:13,560 --> 01:16:15,000 THANK YOU FOR THE INVITATION TO 1778 01:16:15,000 --> 01:16:20,800 PRESENT, AN HONOR AND PRIVILEGE 1779 01:16:20,800 --> 01:16:23,200 TO SHARE A BIT OF OVERVIEW OF 1780 01:16:23,200 --> 01:16:23,760 OUR RESEARCH PROGRAM AND 1781 01:16:23,760 --> 01:16:27,520 HIGHLIGHT ONE OF THE STUDIES 1782 01:16:27,520 --> 01:16:28,360 THAT HAS BEEN RECENTLY DEVELOPED 1783 01:16:28,360 --> 01:16:33,200 IN THE LAB THAT WE'RE EXCITED 1784 01:16:33,200 --> 01:16:33,400 ABOUT. 1785 01:16:33,400 --> 01:16:38,560 FIRST, IN WAY OF INTRODUCTION, 1786 01:16:38,560 --> 01:16:40,080 WHAT WE'RE INTERESTED IN IS 1787 01:16:40,080 --> 01:16:41,240 BARRIER IMMUNITY AT A 1788 01:16:41,240 --> 01:16:42,200 FUNDAMENTAL LEVEL. 1789 01:16:42,200 --> 01:16:44,920 BARRIERS ARE THE PARTS OF THE 1790 01:16:44,920 --> 01:16:47,640 MAMMALIAN HOST SUCH AS SKIN, 1791 01:16:47,640 --> 01:16:49,280 ORAL AND INTESTINAL MUCOSA, THE 1792 01:16:49,280 --> 01:16:51,280 LUNG, EXPOSED TO THE OUTSIDE 1793 01:16:51,280 --> 01:16:51,800 ENVIRONMENT. 1794 01:16:51,800 --> 01:16:54,520 SO ALL OF THESE SURFACES HAVE TO 1795 01:16:54,520 --> 01:16:55,880 PROTECT THIS, HAVE TISSUE 1796 01:16:55,880 --> 01:16:56,600 INTEGRITY. 1797 01:16:56,600 --> 01:17:00,680 BUT AT THE SAME TIME THEY HAVE 1798 01:17:00,680 --> 01:17:03,760 TO COMBAT PATHOGENIC VIRUS AND 1799 01:17:03,760 --> 01:17:05,800 BACTERIA AND ALSO TOLERATE 1800 01:17:05,800 --> 01:17:06,360 INNOCUOUS AGENTS. 1801 01:17:06,360 --> 01:17:08,320 AS WE TRY TO UNDERSTAND 1802 01:17:08,320 --> 01:17:10,160 PHYSIOLOGY AND TISSUE IMMUNITY 1803 01:17:10,160 --> 01:17:11,800 AT THESE SITES A LOT OF THE 1804 01:17:11,800 --> 01:17:13,800 QUESTIONS THAT ARE IMPORTANT FOR 1805 01:17:13,800 --> 01:17:15,560 BARRIER IMMUNITY IN GENERAL ARE 1806 01:17:15,560 --> 01:17:20,240 VERY MUCH SHARED THROUGHOUT ALL 1807 01:17:20,240 --> 01:17:21,240 OF THE SURFACES. 1808 01:17:21,240 --> 01:17:23,000 FUNDAMENTAL QUESTION WE'VE BEEN 1809 01:17:23,000 --> 01:17:29,680 THINKING ABOUT ARE HOW IS TISSUE 1810 01:17:29,680 --> 01:17:31,520 INTEGRITY MAINTAINED, PROTECT 1811 01:17:31,520 --> 01:17:32,400 FROM PATHOGENS CONFERRED, HOW DO 1812 01:17:32,400 --> 01:17:35,360 YOU PROTECT BUT NOT OVERINFLAME 1813 01:17:35,360 --> 01:17:38,320 AND TOLERATE INAC WOWS ELEMENTS? 1814 01:17:38,320 --> 01:17:40,600 HOWEVER, THE QUESTIONS ARE VERY 1815 01:17:40,600 --> 01:17:41,600 MUCH SHARED, THE ANSWER AS 1816 01:17:41,600 --> 01:17:43,880 PEOPLE HAVE BEEN TRYING TO 1817 01:17:43,880 --> 01:17:45,080 UNDERSTAND BARRIER IMMUNITY FOR 1818 01:17:45,080 --> 01:17:47,720 A NUMBER OF DECADES NOW, THE 1819 01:17:47,720 --> 01:17:51,320 ANSWERS BECOME VERY TISSUE 1820 01:17:51,320 --> 01:17:52,320 SPECIFIC. 1821 01:17:52,320 --> 01:17:53,880 IT BECOMES EVIDENT THAT EACH 1822 01:17:53,880 --> 01:17:56,200 TISSUE IS VERY SPECIAL. 1823 01:17:56,200 --> 01:17:57,280 ITS EXPOSURES ARE SPECIAL. 1824 01:17:57,280 --> 01:18:01,160 FOR EXAMPLE, THE SKIN IS EXPOSED 1825 01:18:01,160 --> 01:18:01,960 TO SUNLIGHT. 1826 01:18:01,960 --> 01:18:04,480 VIRUSES THAT ARE AIRBORNE WILL 1827 01:18:04,480 --> 01:18:08,760 COME INTO THE LUNGS, PRIMARILY. 1828 01:18:08,760 --> 01:18:09,960 GAS TOE INTESTINAL TRACT WILL 1829 01:18:09,960 --> 01:18:17,400 COME IN CON CONTACT WITH FOOD, 1830 01:18:17,400 --> 01:18:18,920 SO EXPOSURES ARE DIFFERENT. 1831 01:18:18,920 --> 01:18:23,200 WITH DISEASE, MANY ARE VERY 1832 01:18:23,200 --> 01:18:24,160 TISSUE SPECIFIC. 1833 01:18:24,160 --> 01:18:26,560 SO, IT BECOMES IMPORTANT FOR ALL 1834 01:18:26,560 --> 01:18:28,760 OF US TO THINK OF TISSUE 1835 01:18:28,760 --> 01:18:31,440 IMMUNITY IN A VERY SPECIFIC WAY. 1836 01:18:31,440 --> 01:18:33,360 AND SITE SPECIFIC WAY. 1837 01:18:33,360 --> 01:18:35,240 THE SITE THAT IS OF INTEREST TO 1838 01:18:35,240 --> 01:18:37,200 US IS THE ORAL MUCOSA. 1839 01:18:37,200 --> 01:18:39,600 THIS IS AN ILLUSTRATION THAT 1840 01:18:39,600 --> 01:18:41,480 COMES FROM A REVIEW THAT SARAH 1841 01:18:41,480 --> 01:18:43,440 AND I HAD PUT TOGETHER A COUPLE 1842 01:18:43,440 --> 01:18:44,200 YEARS AGO. 1843 01:18:44,200 --> 01:18:47,200 TO ILLUSTRATE THAT THE ORAL 1844 01:18:47,200 --> 01:18:52,760 MUCOSA IS A VERY SPECIAL SITE, 1845 01:18:52,760 --> 01:18:55,160 OBVIOUSLY PREVENTIVE, RELEVANT 1846 01:18:55,160 --> 01:18:56,920 FOR MANY DENTISTS CLINICALLY 1847 01:18:56,920 --> 01:18:58,840 RELEVANT BUT BEYOND THAT, I WANT 1848 01:18:58,840 --> 01:19:03,040 TO ADVOCATE THAT IT'S A VERY 1849 01:19:03,040 --> 01:19:04,480 IMPORTANT SITE TO THINK ABOUT, 1850 01:19:04,480 --> 01:19:06,880 THE AREA WHERE THE 1851 01:19:06,880 --> 01:19:08,600 GASTROINTESTINAL AND RESPIRATORY 1852 01:19:08,600 --> 01:19:10,240 TRACT COMES INTO CONTACT WITH 1853 01:19:10,240 --> 01:19:11,760 OUTSIDE FOR THE FIRST TIME. 1854 01:19:11,760 --> 01:19:16,040 FOR EXAMPLE, AS WE BREATHE, 1855 01:19:16,040 --> 01:19:16,800 AIRBORNE PARTICLES AND ALLERGENS 1856 01:19:16,800 --> 01:19:18,360 WILL COME THROUGH THE NOSE AND 1857 01:19:18,360 --> 01:19:19,760 MOUTH BEFORE GOING INTO THE 1858 01:19:19,760 --> 01:19:20,080 LUNGS. 1859 01:19:20,080 --> 01:19:23,080 A LOT OF THE COMMENSAL 1860 01:19:23,080 --> 01:19:25,680 MICROBIOTA AS THEY TRAFFIC INTO 1861 01:19:25,680 --> 01:19:27,040 THE LUNGS AND GASTROINTESTINAL 1862 01:19:27,040 --> 01:19:29,200 TRACT PASS THROUGH THE MOUTH. 1863 01:19:29,200 --> 01:19:30,440 OF COURSE FOOD AND DIGESTION IS 1864 01:19:30,440 --> 01:19:32,880 GOING TO START AT THE ORAL 1865 01:19:32,880 --> 01:19:33,240 MUCOSA. 1866 01:19:33,240 --> 01:19:38,080 AND SO WHAT OUR LAB IS 1867 01:19:38,080 --> 01:19:39,280 INTERESTED IN UNDERSTANDING IS 1868 01:19:39,280 --> 01:19:41,280 HOW THE LOCAL IMMUNE SYSTEM IS 1869 01:19:41,280 --> 01:19:47,560 GOING TO BALANCE ALL OF THESE 1870 01:19:47,560 --> 01:19:49,560 ENVIRONMENTAL EXPOSURES AND KEEP 1871 01:19:49,560 --> 01:19:54,280 TISSUE INTEGRITY AND KEEP TISSUE 1872 01:19:54,280 --> 01:19:55,320 FUNCTIONALITY AND MAINTAIN 1873 01:19:55,320 --> 01:19:55,840 HEALTH. 1874 01:19:55,840 --> 01:19:59,800 WE ALSO WANT TO UNDERSTAND HOW 1875 01:19:59,800 --> 01:20:03,440 SOME OF THESE EXPOSURES COULD 1876 01:20:03,440 --> 01:20:05,320 BECOME IMBALANCED AND LEAD TO 1877 01:20:05,320 --> 01:20:06,440 DISEASE. 1878 01:20:06,440 --> 01:20:07,880 WHILE WE'VE BEEN PARTNERING OVER 1879 01:20:07,880 --> 01:20:11,800 THE YEARS WITH MANY AT THE NIH 1880 01:20:11,800 --> 01:20:13,880 HOSPITALS THAT ARE INTERESTED IN 1881 01:20:13,880 --> 01:20:15,080 BIODIVERSE ORAL DISEASE, THE 1882 01:20:15,080 --> 01:20:16,800 DISEASE OF INTEREST THAT OUR LAB 1883 01:20:16,800 --> 01:20:20,120 HAS BEEN FOCUSING ON FOR YEARS 1884 01:20:20,120 --> 01:20:25,360 NOW, PER -- PERIODONTAL 1885 01:20:25,360 --> 01:20:25,560 DISEASE. 1886 01:20:25,560 --> 01:20:28,520 I APPRECIATE I DON'T NEED TO DO 1887 01:20:28,520 --> 01:20:36,960 AN INTRODUCTION ON PERIDONTITIS 1888 01:20:36,960 --> 01:20:40,560 BUT OBVIOUSLY IT'S A PREVALENT 1889 01:20:40,560 --> 01:20:43,320 DISEASE, MILD AND MODERATE 1890 01:20:43,320 --> 01:20:46,280 FORMS, WIDESPREAD THROUGH THE 1891 01:20:46,280 --> 01:20:47,680 POPULATION, IN SEVERE FORMS, 1892 01:20:47,680 --> 01:20:50,240 THAT WILL CAUSE MORBIDITY, THAT 1893 01:20:50,240 --> 01:20:52,320 WILL LEAD TO SURGICAL 1894 01:20:52,320 --> 01:20:55,680 INTERVENTION OFTEN, AND THAT ARE 1895 01:20:55,680 --> 01:20:58,680 ALSO CONNECTED TO VERY 1896 01:20:58,680 --> 01:21:00,920 SIGNIFICANT HEALTH COSTS, IT'S 1897 01:21:00,920 --> 01:21:04,240 STILL SEEN 8% OF THE GENERAL 1898 01:21:04,240 --> 01:21:04,560 POPULATION. 1899 01:21:04,560 --> 01:21:06,640 WE THINK OF A TRIGGER, 1900 01:21:06,640 --> 01:21:07,440 INFLAMMATORY DISEASE. 1901 01:21:07,440 --> 01:21:12,240 WE KNOW BY THE WORK OF MANY IN 1902 01:21:12,240 --> 01:21:17,120 OUR FIELD THAT FOR SUSCEPTIBLE 1903 01:21:17,120 --> 01:21:18,480 INDIVIDUALS DYSBIOTIC MICROBIOME 1904 01:21:18,480 --> 01:21:22,320 WILL COLONIZE THE TOOTH, END UP 1905 01:21:22,320 --> 01:21:23,400 STIMULATING INFLAMMATORY 1906 01:21:23,400 --> 01:21:27,000 RESPONSE IN THE MUCOSA, THIS 1907 01:21:27,000 --> 01:21:28,960 RESPONSE WILL BECOME DESTRUCTIVE 1908 01:21:28,960 --> 01:21:31,360 IN NOT ONLY DESTROYING MUCOSAL 1909 01:21:31,360 --> 01:21:32,560 TISSUES BUT SUPPORTING BONE, 1910 01:21:32,560 --> 01:21:34,640 LEADING TO LOSS OF SUPPORT AND 1911 01:21:34,640 --> 01:21:36,800 EVENTUALLY TO LOSS OF TEETH WHEN 1912 01:21:36,800 --> 01:21:38,040 THIS IS VERY SEVERE. 1913 01:21:38,040 --> 01:21:40,440 AND SO WHILE WE UNDERSTAND A LOT 1914 01:21:40,440 --> 01:21:44,920 OF THESE GENERAL PRINCIPLES, WE 1915 01:21:44,920 --> 01:21:48,680 DON'T FULLY HAVE A TACKLE ON 1916 01:21:48,680 --> 01:21:49,680 PATHOGENESIS MECHANISMS BEST TO 1917 01:21:49,680 --> 01:21:52,920 TARGET FOR THIS DISEASE. 1918 01:21:52,920 --> 01:21:57,200 BEFORE STARTING MANY OF THE 1919 01:21:57,200 --> 01:21:58,640 QUESTIONS, I WANT TO FIRST POSE 1920 01:21:58,640 --> 01:22:01,800 BECAUSE THIS IS ALSO A COUNCIL 1921 01:22:01,800 --> 01:22:03,560 MEETING, A MORE EXISTENTIAL 1922 01:22:03,560 --> 01:22:06,080 QUESTION, THE QUESTION OF WHY 1923 01:22:06,080 --> 01:22:07,040 SHOULD WE BE STUDYING, WHAT IS 1924 01:22:07,040 --> 01:22:10,520 THE REASON FOR US TO CONTINUE 1925 01:22:10,520 --> 01:22:11,200 STUDYING PERIODONTAL DISEASE, 1926 01:22:11,200 --> 01:22:13,840 ISN'T THIS A DISEASE THAT COULD 1927 01:22:13,840 --> 01:22:15,920 JUST BE PREVENTIBLE, PREVENTIBLE 1928 01:22:15,920 --> 01:22:18,760 BY INCREASING ACCESS OF CARE, 1929 01:22:18,760 --> 01:22:19,840 INCREASING ORAL HYGIENE, SO I 1930 01:22:19,840 --> 01:22:22,840 WANT TO KIND OF PITCH TO YOU 1931 01:22:22,840 --> 01:22:24,640 THIS IDEA THAT WE DO HAVE TO DO 1932 01:22:24,640 --> 01:22:28,600 A LOT ON THE PUBLIC HEALTH AND 1933 01:22:28,600 --> 01:22:30,800 ACCESSIBILITY TO CARE ARENA, IN 1934 01:22:30,800 --> 01:22:34,840 THE CONTROL, IN THE ARENA OF 1935 01:22:34,840 --> 01:22:42,200 SMOKING CESSATION INTERVENTIONS, 1936 01:22:42,200 --> 01:22:44,280 IMPORTANT FOR PERIODONTAL 1937 01:22:44,280 --> 01:22:45,400 DISEASE SUSCEPTIBILITY. 1938 01:22:45,400 --> 01:22:47,040 WHEN YOU PROVIDE OPTICAL CARE 1939 01:22:47,040 --> 01:22:48,400 YOU WILL REDUCE DISEASE BURDEN 1940 01:22:48,400 --> 01:22:51,440 IN THE GENERAL COMMUNITY. 1941 01:22:51,440 --> 01:22:54,160 HOWEVER, THIS DOES NOT ABROGATE 1942 01:22:54,160 --> 01:22:54,480 DISEASE. 1943 01:22:54,480 --> 01:22:59,200 THE PROPORTION OF PEOPLE THAT 1944 01:22:59,200 --> 01:23:00,800 ARE SUSCEPTIBLE TO PERIODONTITIS 1945 01:23:00,800 --> 01:23:02,800 DOES NOT DRASTICALLY CHANGE. 1946 01:23:02,800 --> 01:23:06,960 WE STILL HAVE PATIENTS WITH 1947 01:23:06,960 --> 01:23:09,480 SEVERE DISEASE, WITH NEED 1948 01:23:09,480 --> 01:23:10,080 SURGICAL INTERVENTION, 1949 01:23:10,080 --> 01:23:11,120 RECALCITRANT TO TREATMENT. 1950 01:23:11,120 --> 01:23:12,880 EVEN IN THE PRESENCE OF OPTIMAL 1951 01:23:12,880 --> 01:23:17,160 CARE THE WAY WE'VE BEEN 1952 01:23:17,160 --> 01:23:18,000 PROVIDING CARE THERE'S MORE FOR 1953 01:23:18,000 --> 01:23:18,840 US TO UNDERSTAND. 1954 01:23:18,840 --> 01:23:22,600 SO ONE OF THE QUESTIONS THAT OUR 1955 01:23:22,600 --> 01:23:27,880 GROUP IS VERY INTERESTED IN IS 1956 01:23:27,880 --> 01:23:29,600 UNDERSTANDING THE DISEASES 1957 01:23:29,600 --> 01:23:35,200 SUSCEPTIBLE, WERE ARE 1958 01:23:35,200 --> 01:23:35,880 INDIVIDUALS SUSCEPTIBLE TO 1959 01:23:35,880 --> 01:23:37,720 SEVERE FORMS, THIS IS A 1960 01:23:37,720 --> 01:23:40,720 POLYGENIC DISEASE ALSO 1961 01:23:40,720 --> 01:23:41,440 ASSOCIATED WITH ENVIRONMENTAL 1962 01:23:41,440 --> 01:23:42,320 EXPOSURES. 1963 01:23:42,320 --> 01:23:45,480 WE KNOW THAT THERE'S A LOT OF 1964 01:23:45,480 --> 01:23:46,760 TARGETED THERAPIES FOR 1965 01:23:46,760 --> 01:23:49,000 PERIODONTITIS, WHILE WE HAVE 1966 01:23:49,000 --> 01:23:52,600 WAYS OF REMOVING THE MICRO 1967 01:23:52,600 --> 01:23:53,520 BIOFILM, SURGICAL INTERVENTION 1968 01:23:53,520 --> 01:23:55,040 TO CREATE A HEALTHY ENVIRONMENT 1969 01:23:55,040 --> 01:23:56,160 AROUND THE DENTITION. 1970 01:23:56,160 --> 01:24:01,040 WE DON'T HAVE A TARGETED WAY TO 1971 01:24:01,040 --> 01:24:01,680 EITHER TARGET SPECIFIC 1972 01:24:01,680 --> 01:24:03,120 MICROBIOTA THAT MIGHT BE 1973 01:24:03,120 --> 01:24:05,280 IMPORTANT OR SPECIFIC 1974 01:24:05,280 --> 01:24:06,120 INFLAMMATORY PATHWAYS. 1975 01:24:06,120 --> 01:24:09,360 THERE'S ALSO A LOT OF QUESTIONS 1976 01:24:09,360 --> 01:24:12,640 THAT REMAIN REGARDING 1977 01:24:12,640 --> 01:24:14,120 ASSOCIATION OF PERIODONTITIS 1978 01:24:14,120 --> 01:24:15,800 WITH SYSTEMIC DISEASES. 1979 01:24:15,800 --> 01:24:20,520 FROM THE STANDPOINT OF 1980 01:24:20,520 --> 01:24:21,040 FUNDAMENTAL BIOLOGY, 1981 01:24:21,040 --> 01:24:21,800 UNDERSTANDING PERIODONTAL 1982 01:24:21,800 --> 01:24:25,880 DISEASE ONE CAN ARGUE IS ALSO A 1983 01:24:25,880 --> 01:24:28,880 FANTASTIC NICHE TO ADVANCE OUR 1984 01:24:28,880 --> 01:24:32,160 UNDERSTANDING OF HOST-MICROBIOME 1985 01:24:32,160 --> 01:24:32,520 BIOLOGY. 1986 01:24:32,520 --> 01:24:33,560 SO, WHATEVER THESE QUESTIONS AND 1987 01:24:33,560 --> 01:24:35,760 THOUGHTS ARE NOT UNIQUE TO OUR 1988 01:24:35,760 --> 01:24:37,720 PROGRAM ARE VERY MUCH SHARED 1989 01:24:37,720 --> 01:24:40,400 THROUGHOUT THE COMMUNITY. 1990 01:24:40,400 --> 01:24:42,680 BUT WHAT WE'VE TRIED TO DO 1991 01:24:42,680 --> 01:24:44,640 THROUGH UNIQUE LENS AT THE NIH 1992 01:24:44,640 --> 01:24:47,040 IS THE WAY WE'VE TRIED IN THE 1993 01:24:47,040 --> 01:24:49,560 LAST ALMOST DECADE NOW TO TACKLE 1994 01:24:49,560 --> 01:24:50,440 THIS QUESTION. 1995 01:24:50,440 --> 01:24:52,200 AND WE'VE DONE THIS VERY MUCH 1996 01:24:52,200 --> 01:24:54,680 FROM THE LENS OF THE HOST AND 1997 01:24:54,680 --> 01:24:57,440 THE LENS OF THE GENETIC DISEASE. 1998 01:24:57,440 --> 01:24:59,840 SO, AS YOU ALL WILL APPRECIATE 1999 01:24:59,840 --> 01:25:03,040 THE NIH HAS A FANTASTIC CLINICAL 2000 01:25:03,040 --> 01:25:04,440 RESEARCH HOSPITAL, THE LARGEST 2001 01:25:04,440 --> 01:25:05,960 RESEARCH HOSPITAL IN THE WORLD, 2002 01:25:05,960 --> 01:25:08,760 THAT IS VERY MUCH FOCUSED ON 2003 01:25:08,760 --> 01:25:10,480 RARE DISEASE. 2004 01:25:10,480 --> 01:25:14,720 AND SO HERE A COURSE OF PATIENTS 2005 01:25:14,720 --> 01:25:16,160 CAN RARE GENETIC DISORDERS ARE 2006 01:25:16,160 --> 01:25:17,480 BROUGHT TOGETHER SO WE CAN 2007 01:25:17,480 --> 01:25:19,120 UNDERSTAND THEIR DISEASES AND 2008 01:25:19,120 --> 01:25:21,760 TRY TO TARGET THEM, LOOKING AT 2009 01:25:21,760 --> 01:25:23,480 COHORTS ALL TOGETHER AT ONCE. 2010 01:25:23,480 --> 01:25:24,800 ESPECIALLY BECAUSE MANY OF THESE 2011 01:25:24,800 --> 01:25:26,200 DISEASES ARE NOT VERY WELL 2012 01:25:26,200 --> 01:25:28,640 UNDERSTOOD, AND IT'S VERY HARD 2013 01:25:28,640 --> 01:25:36,040 FOR MANY PATIENTS TO GET CARE IN 2014 01:25:36,040 --> 01:25:37,160 THE COMMUNITY. 2015 01:25:37,160 --> 01:25:39,040 EVALUATING PATIENTS WITH SINGLE 2016 01:25:39,040 --> 01:25:42,080 GENE DEFICIENCIES PROVIDES A WAY 2017 01:25:42,080 --> 01:25:44,080 ALSO A WINDOW INTO HUMAN 2018 01:25:44,080 --> 01:25:44,280 BIOLOGY. 2019 01:25:44,280 --> 01:25:49,000 WHILE WE LOOK AT THE GENOTYPES 2020 01:25:49,000 --> 01:25:50,640 AND GENETIC, SPECIFIC GENETIC 2021 01:25:50,640 --> 01:25:53,480 DEFECTS, WE CAN LING THEM OFTEN 2022 01:25:53,480 --> 01:25:54,480 TO PARTICULAR PHENOTYPES AND 2023 01:25:54,480 --> 01:25:58,520 THIS CAN TELL US HOW SPECIFIC 2024 01:25:58,520 --> 01:26:01,440 GENOME-RELATED PATHWAY COULD BE 2025 01:26:01,440 --> 01:26:02,000 INFLUENCING HUMAN BIOLOGY. 2026 01:26:02,000 --> 01:26:03,840 AND SO THIS IS DONE BY MANY OF 2027 01:26:03,840 --> 01:26:05,440 US AT THE NIH CENTER, DEPENDING 2028 01:26:05,440 --> 01:26:07,400 ON THE DISEASE OF INTEREST, AND 2029 01:26:07,400 --> 01:26:11,800 THIS IS THE WAY THAT WE'VE BEEN 2030 01:26:11,800 --> 01:26:17,880 TRYING TO APPROACH OUR 2031 01:26:17,880 --> 01:26:21,120 UNDERSTANDING INTO GENETIC 2032 01:26:21,120 --> 01:26:22,600 SUSCEPTIBILITY, STARTING WITH 2033 01:26:22,600 --> 01:26:25,920 MAMMALIAN GENE DISEASES, 2034 01:26:25,920 --> 01:26:27,320 PHENOTYPING TO LINK GENOTYPE 2035 01:26:27,320 --> 01:26:32,040 WITH PHENOTYPE OF SEVERE EARLY 2036 01:26:32,040 --> 01:26:33,800 ONSET PERIODONTITIS, WORK WITH 2037 01:26:33,800 --> 01:26:36,520 SAMPLES FROM THE MICROBIOME AND 2038 01:26:36,520 --> 01:26:39,360 TISSUE SIDE AND SYSTEMIC 2039 01:26:39,360 --> 01:26:41,440 IMMUNITY SIDE TO START 2040 01:26:41,440 --> 01:26:41,880 UNDERSTANDING IMMUNE 2041 01:26:41,880 --> 01:26:42,840 RESPONSIVENESS IN THESE 2042 01:26:42,840 --> 01:26:43,400 PATIENTS. 2043 01:26:43,400 --> 01:26:44,920 WHEN APPLICABLE WE MOVE INTO 2044 01:26:44,920 --> 01:26:46,040 ANIMAL MODELS, PARTICULARLY WHEN 2045 01:26:46,040 --> 01:26:48,520 WE HAVE AN ANIMAL MODEL THAT 2046 01:26:48,520 --> 01:26:50,000 WILL PHENOCOPY A DISEASE, AND 2047 01:26:50,000 --> 01:26:52,040 THEN THE MODELS BECOME A PLACE 2048 01:26:52,040 --> 01:26:53,920 WHERE WE CAN EXPAND THE 2049 01:26:53,920 --> 01:26:57,440 CONNECTIVE UNDERSTANDING, AND WE 2050 01:26:57,440 --> 01:26:58,960 CAN ALSO PERFORM PRE-CLINICAL 2051 01:26:58,960 --> 01:27:02,480 TARGETING WHEN POSSIBLE. 2052 01:27:02,480 --> 01:27:04,880 NOW, OUR INTENT IS THREE-FOLD 2053 01:27:04,880 --> 01:27:06,800 BUT I'M SHOWING ONE HERE. 2054 01:27:06,800 --> 01:27:08,480 A LOT OF THE RARE DISEASE THAT 2055 01:27:08,480 --> 01:27:12,440 WE SEE WHEN WE HAVE GENETIC 2056 01:27:12,440 --> 01:27:14,000 DISRUPTION LEAD TO SIGNIFICANT 2057 01:27:14,000 --> 01:27:15,040 CLINICAL PHENOTYPES SO WE WANT 2058 01:27:15,040 --> 01:27:17,240 TO TRY TO MOVE INTO HUMAN 2059 01:27:17,240 --> 01:27:19,080 INTERVENTION AT LEAST IN THE 2060 01:27:19,080 --> 01:27:21,720 RARE DISEASE ARENA, AND THE NIH 2061 01:27:21,720 --> 01:27:23,600 IS AN IDEAL PLACE TO DO SO. 2062 01:27:23,600 --> 01:27:29,640 BUT AT THE SAME TIME, WE WANT TO 2063 01:27:29,640 --> 01:27:30,400 FURTHER MECHANISTIC 2064 01:27:30,400 --> 01:27:32,160 UNDERSTANDING OF ORAL MUCOSAL 2065 01:27:32,160 --> 01:27:36,080 IMMUNITY AND MUCOSAL BIOLOGY. 2066 01:27:36,080 --> 01:27:38,960 AND IF POSSIBLE, BE ABLE TO 2067 01:27:38,960 --> 01:27:40,200 EDUCATE OUR UNDERSTANDING OF 2068 01:27:40,200 --> 01:27:42,520 SYSTEMIC DISEASES TO SEE HOW 2069 01:27:42,520 --> 01:27:44,200 UNDERSTANDING THESE GENETIC 2070 01:27:44,200 --> 01:27:46,280 FORMS OF DISEASE CAN TRANSLATE 2071 01:27:46,280 --> 01:27:48,040 INTO SOME LEVEL OF UNDERSTANDING 2072 01:27:48,040 --> 01:27:53,680 OF COMMON FORMS OF DISEASE. 2073 01:27:53,680 --> 01:27:55,880 AND SO THROUGH THE YEARS TO OUR 2074 01:27:55,880 --> 01:27:57,640 STUDY PARTICULARLY IN GENETIC 2075 01:27:57,640 --> 01:28:00,280 IMMUNODEFICIENCIES WE VERY MUCH 2076 01:28:00,280 --> 01:28:02,560 FOCUSED ON SPECIFIC IMMUNE 2077 01:28:02,560 --> 01:28:07,880 PATHWAYS WHICH I'M CALLING HERE 2078 01:28:07,880 --> 01:28:09,160 THE Th17 NEUTROPHIL AXIS. 2079 01:28:09,160 --> 01:28:10,760 I WILL BE SUPERFICIAL IN MY 2080 01:28:10,760 --> 01:28:12,080 DESCRIPTION FOR THE PURPOSE OF 2081 01:28:12,080 --> 01:28:14,160 THIS TALK, OF THE BASIC 2082 01:28:14,160 --> 01:28:16,360 IMMUNOLOGY HERE BUT I'M HAPPY TO 2083 01:28:16,360 --> 01:28:18,080 ANSWER FURTHER QUESTIONS. 2084 01:28:18,080 --> 01:28:23,000 WE'VE BEEN FOCUSING ON THESE 2085 01:28:23,000 --> 01:28:27,280 HELPER T CELLS, Th17, CD4 2086 01:28:27,280 --> 01:28:36,520 POSITIVE CELLS THAT SECRETE 2087 01:28:36,520 --> 01:28:37,080 IL-17. 2088 01:28:37,080 --> 01:28:39,520 NEUTROPHILS ARE THE MOST 2089 01:28:39,520 --> 01:28:41,320 ABUNDANT IN THE CIRCULATION, 2090 01:28:41,320 --> 01:28:42,960 THESE ARE OUR PRINCIPAL INNATE 2091 01:28:42,960 --> 01:28:44,360 IMMUNE CELLS THAT WILL RUN TO 2092 01:28:44,360 --> 01:28:46,240 THE SITE OF INFECTION AND 2093 01:28:46,240 --> 01:28:48,640 INFLAMMATION AND THEY HAVE A 2094 01:28:48,640 --> 01:28:50,840 PRINCIPAL ROLE IN ANTIMICROBIAL 2095 01:28:50,840 --> 01:28:52,720 DEFENSE. 2096 01:28:52,720 --> 01:28:55,440 NEUTROPHILS WILL TRY TO COMBAT 2097 01:28:55,440 --> 01:29:00,440 INFECTION EITHER BY EATING UP 2098 01:29:00,440 --> 01:29:04,480 BACTERIA, BY SECRETING ENZYMES 2099 01:29:04,480 --> 01:29:07,560 OR SECRETING THEIR DNA CONTENTS 2100 01:29:07,560 --> 01:29:11,680 THAT WILL TRAP LARGER MICROBES 2101 01:29:11,680 --> 01:29:14,160 AND SECRETE THEIR ENZYMES AT THE 2102 01:29:14,160 --> 01:29:14,920 SAME TIME. 2103 01:29:14,920 --> 01:29:19,480 THE PARADIGM IN IMMUNOLOGY FOR 2104 01:29:19,480 --> 01:29:21,040 MANY YEARS, WHEN YOU DON'T 2105 01:29:21,040 --> 01:29:24,440 HAVE -- WE HAVE ISSUES WITH 2106 01:29:24,440 --> 01:29:25,080 NEUTROPHIL ABUNDANCE, OR 2107 01:29:25,080 --> 01:29:26,720 RECRUITMENT, YOU END UP WITH 2108 01:29:26,720 --> 01:29:27,960 INFECTION. 2109 01:29:27,960 --> 01:29:29,680 WHEN YOU HAVE TOO MANY 2110 01:29:29,680 --> 01:29:31,080 NEUTROPHILS YOU WILL END UP WITH 2111 01:29:31,080 --> 01:29:31,680 INFLAMMATION. 2112 01:29:31,680 --> 01:29:33,080 FOR THE WORK OF OUR GROUP AND 2113 01:29:33,080 --> 01:29:39,080 OTHERS AT THE NIH AND 2114 01:29:39,080 --> 01:29:39,960 EXTRAMURALLY WE'VE CHALLENGED 2115 01:29:39,960 --> 01:29:42,800 PARADIGM TO INCLUDE IN THE 2116 01:29:42,800 --> 01:29:44,240 ABSENCE OF NEUTROPHILS YOU END 2117 01:29:44,240 --> 01:29:50,520 UP WITH SETTINGS OF INFLAMMATION 2118 01:29:50,520 --> 01:29:55,600 BUT I WON'T TALK ABOUT THIS 2119 01:29:55,600 --> 01:29:55,960 TODAY. 2120 01:29:55,960 --> 01:29:57,360 IN Th17 NEUTROPHIL BIOLOGY OUR 2121 01:29:57,360 --> 01:30:00,080 LAB AS WORKED A LOT, THERE'S A 2122 01:30:00,080 --> 01:30:01,320 NUMBER OF PEOPLE HERE, PAPERS 2123 01:30:01,320 --> 01:30:04,440 AND PEOPLE HERE I WILL NOT 2124 01:30:04,440 --> 01:30:06,120 PRESENT TODAY BUT I WANTED TO 2125 01:30:06,120 --> 01:30:08,720 KIND OF DO A SMALL SHOUT OUT TO 2126 01:30:08,720 --> 01:30:11,480 SAY THAT WE'VE BEEN VERY 2127 01:30:11,480 --> 01:30:12,640 INTERESTED IN FUNDAMENTAL Th17 2128 01:30:12,640 --> 01:30:14,680 BIOLOGY, A LOT OF EARLY 2129 01:30:14,680 --> 01:30:15,840 UNDERSTANDING OF IL-17 AND 2130 01:30:15,840 --> 01:30:23,760 Th17 CAME FROM THE WORK OF 2131 01:30:23,760 --> 01:30:24,360 SARAH GAFFEN, PARTICULARLY 2132 01:30:24,360 --> 01:30:25,480 FUNGAL IMMUNOLOGY. 2133 01:30:25,480 --> 01:30:30,600 WE'VE EXPANDED INTO PERIODONTAL 2134 01:30:30,600 --> 01:30:31,440 IMMUNITY. 2135 01:30:31,440 --> 01:30:32,400 EVEN THE SAME CYTOKINE WITH 2136 01:30:32,400 --> 01:30:34,720 DIFFERENT LOCATION IN THE MOUTH 2137 01:30:34,720 --> 01:30:37,320 CAN HAVE DIVERSE FACTIONS. 2138 01:30:37,320 --> 01:30:39,840 RECENTLY WE'VE WORKED VERY MUCH 2139 01:30:39,840 --> 01:30:41,840 ON AN EFFORT TO CREATE A SINGLE 2140 01:30:41,840 --> 01:30:44,240 CELL ATLAS FOR THE ORAL MUCOSA. 2141 01:30:44,240 --> 01:30:45,320 AND I WON'T HAVE TIME 2142 01:30:45,320 --> 01:30:48,280 UNFORTUNATELY TO SPEAK OF ANY OF 2143 01:30:48,280 --> 01:30:50,080 THIS WORK TODAY. 2144 01:30:50,080 --> 01:30:53,520 IN THE SETTING OF GENETIC 2145 01:30:53,520 --> 01:30:55,040 IMMUNODEFICIENCY WE WORKED BOTH 2146 01:30:55,040 --> 01:30:58,680 ON PATIENTS THAT HAVE ISSUES 2147 01:30:58,680 --> 01:31:00,840 WITH NEUTROPHIL DEFICIENCIES AS 2148 01:31:00,840 --> 01:31:02,400 WELL AS NEUTROPHIL OVERABUNDANCE 2149 01:31:02,400 --> 01:31:04,240 AND IT'S BECOME EVIDENT TO US 2150 01:31:04,240 --> 01:31:06,000 THE BALANCE OF NEUTROPHILS 2151 01:31:06,000 --> 01:31:09,280 BECOMES VERY IMPORTANT FOR 2152 01:31:09,280 --> 01:31:11,040 NEUTROPHIL -- FOR HOMEOSTASIS. 2153 01:31:11,040 --> 01:31:14,080 SO OUR WORK IN NEUTROPHIL 2154 01:31:14,080 --> 01:31:15,560 DEFICIENCIES HAS BEEN 2155 01:31:15,560 --> 01:31:18,600 PARTICULARLY FOCUSED ON RARE 2156 01:31:18,600 --> 01:31:21,360 DISEASE CALLED LEUKOCYTE 2157 01:31:21,360 --> 01:31:22,120 ADHESION DEFICIENCY IN 2158 01:31:22,120 --> 01:31:24,720 COLLABORATION WITH NIAID AND 2159 01:31:24,720 --> 01:31:25,920 EXTRAMURALLY WITH GEORGE, AND I 2160 01:31:25,920 --> 01:31:27,400 WON'T HAVE TIME TO PRESENT ANY 2161 01:31:27,400 --> 01:31:29,160 OF THIS WORK TODAY. 2162 01:31:29,160 --> 01:31:30,640 I DECIDED FOR THE PURPOSE IT'S 2163 01:31:30,640 --> 01:31:35,480 OF MY TALK TODAY TO JUST FOCUS 2164 01:31:35,480 --> 01:31:37,000 ON ONLY ONE TOPIC, AND ON THE 2165 01:31:37,000 --> 01:31:39,280 STUDY THAT HAS BEEN A 2166 01:31:39,280 --> 01:31:42,160 COLLABORATIVE STUDY BETWEEN OUR 2167 01:31:42,160 --> 01:31:47,000 LAB AND THAT OF THE NIH, AND LED 2168 01:31:47,000 --> 01:31:51,360 BY A TALENTED POSTDOCTORAL 2169 01:31:51,360 --> 01:31:52,000 FELLOW, SILVA, CO-MENTORED 2170 01:31:52,000 --> 01:31:53,120 BETWEEN THE TWO LABS. 2171 01:31:53,120 --> 01:31:56,200 I WANT TO HIGHLIGHT THE FACT 2172 01:31:56,200 --> 01:31:57,800 THESE STUDIES THAT ARE BEDSIDE 2173 01:31:57,800 --> 01:32:00,520 TO BENCH AND BACK START FROM 2174 01:32:00,520 --> 01:32:01,840 GENETIC IMMUNE DEFICIENCY GOING 2175 01:32:01,840 --> 01:32:04,360 TO THE LAB WITH INTENT OF MOVING 2176 01:32:04,360 --> 01:32:06,000 INTO THE CLINIC, HIGHLY 2177 01:32:06,000 --> 01:32:08,440 COLLABORATIVE AS LARRY TABAK 2178 01:32:08,440 --> 01:32:12,080 JUST INTRODUCED TO US THESE 2179 01:32:12,080 --> 01:32:12,800 BIGGER QUESTIONS REALLY 2180 01:32:12,800 --> 01:32:13,800 NECESSITATE WORK FROM MANY 2181 01:32:13,800 --> 01:32:15,880 FIELDS, MANY PEOPLE, IN ORDER TO 2182 01:32:15,880 --> 01:32:18,920 BE PUSHED FORWARD. 2183 01:32:18,920 --> 01:32:20,720 AND BECAUSE THIS CAN BE UNIQUELY 2184 01:32:20,720 --> 01:32:21,720 DONE AT THE NIH CLINICAL CENTER 2185 01:32:21,720 --> 01:32:23,880 I THOUGHT IT WOULD BE MORE 2186 01:32:23,880 --> 01:32:26,160 RELEVANT FOR ME TO PRESENT THIS 2187 01:32:26,160 --> 01:32:29,240 WORK TO YOU TODAY. 2188 01:32:29,240 --> 01:32:36,680 AND SO THE DISEASE THAT WE 2189 01:32:36,680 --> 01:32:38,080 FOCUSED ON HERE PLASMINOGEN 2190 01:32:38,080 --> 01:32:43,520 DEFICIENCY, THE FORM OF THE 2191 01:32:43,520 --> 01:32:45,800 ENZYME PLASMID, PATIENTS WITH 2192 01:32:45,800 --> 01:32:48,200 END UP WITH REDUCED ENZYMATIC 2193 01:32:48,200 --> 01:32:48,440 ACTIVITY. 2194 01:32:48,440 --> 01:32:50,600 AND CLINICAL PHENOTYPE-WISE THEY 2195 01:32:50,600 --> 01:32:53,240 WILL HAVE WIDESPREAD MUCOSAL 2196 01:32:53,240 --> 01:32:54,000 IMMUNOPATHOLOGY. 2197 01:32:54,000 --> 01:32:58,720 THEY HAVE LESIONS IN THEIR 2198 01:32:58,720 --> 01:33:00,560 CONJUNCTIVA, GUT, LUNG, VAGINA, 2199 01:33:00,560 --> 01:33:01,000 AND MOUTH. 2200 01:33:01,000 --> 01:33:03,000 AND SO FOR THE DENTIST AND NOT 2201 01:33:03,000 --> 01:33:05,360 DENTISTS IN THE ROOM I HAVE HERE 2202 01:33:05,360 --> 01:33:10,320 AN X-RAY OF A 15-YEAR-OLD 2203 01:33:10,320 --> 01:33:12,960 PATIENT, PATIENT WITH 2204 01:33:12,960 --> 01:33:17,240 PLASMINOGEN DEFICIENCIES 2205 01:33:17,240 --> 01:33:18,000 ASSOCIATINGED PERIODONTITIS. 2206 01:33:18,000 --> 01:33:22,800 THIRD MOLARS ARE NOT OUT. 2207 01:33:22,800 --> 01:33:24,000 DENTITION, PRETTY MUCH OF 2208 01:33:24,000 --> 01:33:26,840 MAJORITY OF BONE HAS BEEN LOST. 2209 01:33:26,840 --> 01:33:28,360 THIS IS A VERY SEVERE CASE. 2210 01:33:28,360 --> 01:33:30,320 THESE ARE THE KIND OF CASES THAT 2211 01:33:30,320 --> 01:33:36,520 WE HAVE BEEN SEEING AT THE NIH 2212 01:33:36,520 --> 01:33:40,840 HOSPITAL ASSOCIATED GENETIC 2213 01:33:40,840 --> 01:33:41,240 IMMUNODEFICIENCY. 2214 01:33:41,240 --> 01:33:43,480 SO THOMAS A NUMBER OF YEARS AGO 2215 01:33:43,480 --> 01:33:46,120 CAME TO ME, HE'S HAD THE 2216 01:33:46,120 --> 01:33:49,720 INTEREST IN PROTEASE, WORKED ON 2217 01:33:49,720 --> 01:33:50,920 PLASMINOGEN AS AN ENZYME FOR 2218 01:33:50,920 --> 01:33:52,120 MANY YEARS WITH THE IDEA THAT 2219 01:33:52,120 --> 01:33:55,320 THIS IS AN AREA WHERE WE HAVE 2220 01:33:55,320 --> 01:33:56,960 COMBINED INTEREST AND WE CAN 2221 01:33:56,960 --> 01:33:59,040 KIND OF PUT OUR BRAINS TOGETHER 2222 01:33:59,040 --> 01:34:00,800 AND OUR EFFORTS TOGETHER TO TRY 2223 01:34:00,800 --> 01:34:07,360 TO UNDERSTAND THE ROLE IN 2224 01:34:07,360 --> 01:34:08,480 MUCOSAL IMMUNOLOGY. 2225 01:34:08,480 --> 01:34:13,520 JUST A COUPLE MORE WORDS ABOUT 2226 01:34:13,520 --> 01:34:14,720 PLASMINOGEN AND ITS FUNCTION. 2227 01:34:14,720 --> 01:34:23,000 IT NEEDS TO BE ACTIVATED INTO 2228 01:34:23,000 --> 01:34:28,680 PLASMIN TO DEGRADE FIBRIN, THE 2229 01:34:28,680 --> 01:34:39,240 MAIN COMPONENT RELEASED FROM THE 2230 01:34:41,560 --> 01:34:47,840 VASCULATURE TO CREATE CLOTS, 2231 01:34:47,840 --> 01:34:51,120 NOT JUST RELEED WHEN BROKEN BUT 2232 01:34:51,120 --> 01:34:52,560 WHEN INFLAMED. 2233 01:34:52,560 --> 01:34:54,400 WE NEED FIBRIN FOR HEMOSTASIS, 2234 01:34:54,400 --> 01:34:56,960 BUT WE ALSO NEED FIBRIN TO BE 2235 01:34:56,960 --> 01:34:58,800 REMOVED IN A TIMELY FASHION TO 2236 01:34:58,800 --> 01:35:01,400 ALLOW FOR TISSUE REPAIR. 2237 01:35:01,400 --> 01:35:05,120 AND SO THAT'S THE ROLE OF 2238 01:35:05,120 --> 01:35:08,480 PLASMID, IT COMMENTS IN AND 2239 01:35:08,480 --> 01:35:10,200 DEGRADES FIBRIN AFTER THE CLOT 2240 01:35:10,200 --> 01:35:11,280 IS FORMED. 2241 01:35:11,280 --> 01:35:15,200 AND SO IN THE ABSENCE OF PLASMID 2242 01:35:15,200 --> 01:35:18,920 WHAT WILL HAPPEN IS THAT FIBRIN 2243 01:35:18,920 --> 01:35:21,120 WILL PERSIST IN THE WOUND, IN 2244 01:35:21,120 --> 01:35:23,360 TISSUES, IN A WAY THAT WILL 2245 01:35:23,360 --> 01:35:25,040 CREATE A CHRONIC INFLAMMATORY 2246 01:35:25,040 --> 01:35:27,640 TYPE OF CONDITION. 2247 01:35:27,640 --> 01:35:29,360 NOW, WE WERE VERY FORTUNATE WE 2248 01:35:29,360 --> 01:35:30,440 HAD A FANTASTIC MOUSE MODEL TO 2249 01:35:30,440 --> 01:35:31,600 WORK WITH. 2250 01:35:31,600 --> 01:35:35,440 THIS IS A MOUSE THAT THOMAS HAD 2251 01:35:35,440 --> 01:35:37,840 MADE TWO DECADES AGO, 2252 01:35:37,840 --> 01:35:40,120 PLASMINOGEN KNOCKOUT MOUSE, THIS 2253 01:35:40,120 --> 01:35:45,480 MOUSE TRULY HAD MANY FEATURES 2254 01:35:45,480 --> 01:35:47,800 THAT COPY HUMAN BEINGS, 2255 01:35:47,800 --> 01:35:55,160 SPONTANEOUS IMMUNOPATHOLOGY IN 2256 01:35:55,160 --> 01:36:05,640 MUCOSAL SITE, CONJUNCTIVITIS, 2257 01:36:10,040 --> 01:36:10,920 SPONTANEOUS PERIODONTAL DISEASE. 2258 01:36:10,920 --> 01:36:13,360 BECAUSE THIS WAS REALLY A GREAT 2259 01:36:13,360 --> 01:36:14,840 MODEL, THIS GAVE US THE 2260 01:36:14,840 --> 01:36:18,840 OPPORTUNITY TO ASK THE QUESTION 2261 01:36:18,840 --> 01:36:21,000 HOW DOES PLASMINOGEN DEFICIENCY 2262 01:36:21,000 --> 01:36:23,320 LEAD TO MUCOSAL PATHOLOGY AND WE 2263 01:36:23,320 --> 01:36:25,160 STARTED LOOKING AT THIS THROUGH 2264 01:36:25,160 --> 01:36:30,520 THE AREA OF ORAL MUCOSAL 2265 01:36:30,520 --> 01:36:31,600 IMMUNOPATHOLOGY, PERIODONTITIS 2266 01:36:31,600 --> 01:36:31,960 FIRST. 2267 01:36:31,960 --> 01:36:37,640 FIRST TO DESCRIBE TO YOU OR SHOW 2268 01:36:37,640 --> 01:36:40,000 DATA THAT LAKMALI HAD ON 2269 01:36:40,000 --> 01:36:42,120 PERIODONTITIS HERE SHE SHOWS 2270 01:36:42,120 --> 01:36:45,280 MICRO CT SCAN OF A KNOCKOUT 2271 01:36:45,280 --> 01:36:47,040 MOUSE VERSUS WILDTYPE LATER MATE 2272 01:36:47,040 --> 01:36:49,480 CONTROL, IN THE WILD TYPE AT 24 2273 01:36:49,480 --> 01:36:51,440 WEEKS WHERE THIS IS TAKEN, YOU 2274 01:36:51,440 --> 01:36:54,840 SEE WHERE THE LEVEL OF BONE IS 2275 01:36:54,840 --> 01:36:58,160 AS OPPOSED TO IN THE PLASMINOGEN 2276 01:36:58,160 --> 01:37:03,800 KNOCKOUT THE BONE IS 2277 01:37:03,800 --> 01:37:05,120 SIGNIFICANTLY REDUCED AND 2278 01:37:05,120 --> 01:37:08,840 RECEDED, BETTER TO BE SHOWN WITH 2279 01:37:08,840 --> 01:37:10,880 THE MAGNIFICATION AT EARLY 2280 01:37:10,880 --> 01:37:12,840 WEEKS, 11 TO 12 WEEKS WE HAVE 2281 01:37:12,840 --> 01:37:16,080 SIGNIFICANT BONE LOSS AND THIS 2282 01:37:16,080 --> 01:37:17,240 BECOMES A LOT MORE SIGNIFICANT 2283 01:37:17,240 --> 01:37:18,200 WITH AGE. 2284 01:37:18,200 --> 01:37:19,680 IMPORTANTLY THIS IS A 2285 01:37:19,680 --> 01:37:25,080 SPONTANEOUS PHENOTYPE AS I 2286 01:37:25,080 --> 01:37:25,760 MENTIONED. 2287 01:37:25,760 --> 01:37:29,560 WE DON'T ELICIT PERIODONTAL 2288 01:37:29,560 --> 01:37:34,040 DISEASE, THIS SPONTANEOUSLY 2289 01:37:34,040 --> 01:37:34,320 OCCURS. 2290 01:37:34,320 --> 01:37:40,800 WHEN LAKMALI LOOKED AT MUCOSAL 2291 01:37:40,800 --> 01:37:43,360 TISSUES, DEPOSITS ARE CONSISTENT 2292 01:37:43,360 --> 01:37:44,320 WITH FIBRIN POSITION, 2293 01:37:44,320 --> 01:37:49,840 DISORGANIZATION OF THE TISSUE, 2294 01:37:49,840 --> 01:37:50,880 SWELLING, AND INFLAMMATORY 2295 01:37:50,880 --> 01:37:51,560 INFILTRATION. 2296 01:37:51,560 --> 01:37:55,680 THE QUESTION BECOMES IS THIS 2297 01:37:55,680 --> 01:38:00,960 ACCUMULATION OF FIBRIN? 2298 01:38:00,960 --> 01:38:03,640 AND SO THE SIMPLE GENETIC WAY TO 2299 01:38:03,640 --> 01:38:09,120 ANSWER THIS QUESTION WAS TO 2300 01:38:09,120 --> 01:38:10,360 CROSS THE PLASMINOGEN KNOCKOUT 2301 01:38:10,360 --> 01:38:12,960 MOUSE, IF WE REMOVE FIBER DO WE 2302 01:38:12,960 --> 01:38:14,120 RESCUE DISEASE? 2303 01:38:14,120 --> 01:38:19,040 INDEED YOU'LL SEE THIS IN THE 2304 01:38:19,040 --> 01:38:29,240 MICROCT SCAN, ALSO QUANTITY FIND 2305 01:38:29,240 --> 01:38:30,520 THIS IS COMPLETELY ARRESTED. 2306 01:38:30,520 --> 01:38:32,680 THE QUESTION IS HOW DOES FIBRIN 2307 01:38:32,680 --> 01:38:36,880 MEDIATE THESE LESIONS OF 2308 01:38:36,880 --> 01:38:38,120 IMMUNOPATHOLOGY? 2309 01:38:38,120 --> 01:38:46,160 AND SO THE NUMBER OF ASSAYS 2310 01:38:46,160 --> 01:38:46,720 CHARACTERIZING INFLAMMATORY 2311 01:38:46,720 --> 01:38:47,560 LESIONS OF PERIODONTITIS I WON'T 2312 01:38:47,560 --> 01:38:49,200 TIRE YOU WITH THE DETAILS OF 2313 01:38:49,200 --> 01:38:49,600 DATA. 2314 01:38:49,600 --> 01:38:51,320 THIS IS ALREADY PUBLISHED. 2315 01:38:51,320 --> 01:38:55,040 SHE'S DONE FLOW CYTOMETRY OF 2316 01:38:55,040 --> 01:38:56,640 IMMUNE CELL POPULATION, RNA, 2317 01:38:56,640 --> 01:38:57,840 TRANSCRIPTOMIC ANALYSIS, WITH 2318 01:38:57,840 --> 01:39:02,200 ALL OF THESE ASSAYS COLLECTIVELY 2319 01:39:02,200 --> 01:39:07,160 SHOWING AND ALSO DEMONSTRATED 2320 01:39:07,160 --> 01:39:10,680 HERE IN HISTOLOGY IS FIBRIN 2321 01:39:10,680 --> 01:39:20,800 DEPOSITION IN TISSUE, SPECIFIC 2322 01:39:20,800 --> 01:39:23,280 ANTIBODY FOR FIBRINOGEN, A 2323 01:39:23,280 --> 01:39:25,080 SPECIFIC ANTIBODY FOR 2324 01:39:25,080 --> 01:39:25,400 NEUTROPHILS. 2325 01:39:25,400 --> 01:39:26,720 NEUTROPHILS ARE ACCUMULATING ON 2326 01:39:26,720 --> 01:39:29,040 TOP OF FIBRIN BUT ALSO 2327 01:39:29,040 --> 01:39:30,600 SURROUNDING THE FIBRIN DEPOSITS. 2328 01:39:30,600 --> 01:39:35,440 AND SO THE NEXT QUESTION BECOMES 2329 01:39:35,440 --> 01:39:39,360 CAN THIS FIBRIN -- IS THERE A 2330 01:39:39,360 --> 01:39:40,120 FIBRIN-NEUTROPHIL INTERACTION 2331 01:39:40,120 --> 01:39:44,640 THAT PLAYS A ROLE IN THIS 2332 01:39:44,640 --> 01:39:44,920 PATHOLOGY? 2333 01:39:44,920 --> 01:39:46,600 THIS BECOMES RELEVANT BECAUSE OF 2334 01:39:46,600 --> 01:39:49,080 PRIOR KNOWLEDGE THAT WE HAD FROM 2335 01:39:49,080 --> 01:39:52,200 THE LITERATURE. 2336 01:39:52,200 --> 01:39:56,320 FIBRIN HAS A CRYPTIC DOMAIN THAT 2337 01:39:56,320 --> 01:40:04,320 BINDS CD11B, A MARKER, A 2338 01:40:04,320 --> 01:40:08,240 RECEPTOR SEEN IN ALL MYELOID 2339 01:40:08,240 --> 01:40:10,120 CELLS INCLUDING NEUTROPHILS. 2340 01:40:10,120 --> 01:40:11,680 THIS DOMAIN THAT'S BEEN 2341 01:40:11,680 --> 01:40:13,080 CHARACTERIZED IN FIBRIN IS 2342 01:40:13,080 --> 01:40:16,440 PRESENT IN FIBRIN ONLY WHEN 2343 01:40:16,440 --> 01:40:18,880 FIBRIN IS LAID DOWN IN CLOTS OR 2344 01:40:18,880 --> 01:40:22,480 TISSUE, WHEN IN CIRCULATION THIS 2345 01:40:22,480 --> 01:40:25,160 IS NOT SHOWN AS OPPOSED TO 2346 01:40:25,160 --> 01:40:27,080 CROSS-LINKED IN A TISSUE IT 2347 01:40:27,080 --> 01:40:28,200 BECOMES EXPOSED. 2348 01:40:28,200 --> 01:40:34,960 THE FANTASTIC TOOL WE HAD HERE 2349 01:40:34,960 --> 01:40:40,440 IS A COLLABORATOR HAD CREATED 2350 01:40:40,440 --> 01:40:41,640 KNOCK-IN MOUSE FOR FIBRIN, AT 2351 01:40:41,640 --> 01:40:43,160 THIS SPECIFIC SITE. 2352 01:40:43,160 --> 01:40:48,960 WHAT HE DID, CREATED A MUTATION 2353 01:40:48,960 --> 01:40:52,440 WHERE FIBRIN IS INTACT, CAN FORM 2354 01:40:52,440 --> 01:40:53,760 CLOTS, IT'S ACCUMULATED 2355 01:40:53,760 --> 01:40:57,200 NORMALLY, BUT THERE IS NO 2356 01:40:57,200 --> 01:40:58,480 BINDING SITE FOR CD11B. 2357 01:40:58,480 --> 01:41:02,640 WE THOUGHT WHAT WE COULD DO HERE 2358 01:41:02,640 --> 01:41:12,840 IS WE COULD CROSS PLASMINOGEN 2359 01:41:12,840 --> 01:41:14,360 KNOCKOUT, WON'T BIND MYELOID 2360 01:41:14,360 --> 01:41:15,360 CELLS INCLUDING NEUTROPHILS. 2361 01:41:15,360 --> 01:41:17,960 IF YOU TAKE JUST THE BINDING OF 2362 01:41:17,960 --> 01:41:19,080 NEUTROPHILS AWAY CAN YOU RESCUE 2363 01:41:19,080 --> 01:41:19,480 DISEASE? 2364 01:41:19,480 --> 01:41:22,160 THIS WAS AN IMPORTANT EXPERIMENT 2365 01:41:22,160 --> 01:41:23,200 FOR US. 2366 01:41:23,200 --> 01:41:28,480 AND SO WE WERE THRILLED WHEN 2367 01:41:28,480 --> 01:41:30,760 LAKMALI HAD THE DATA THAT SHOWS 2368 01:41:30,760 --> 01:41:31,320 ABSOLUTE RESCUE. 2369 01:41:31,320 --> 01:41:34,400 ABOVE AND BEYOND WHAT WE HAD 2370 01:41:34,400 --> 01:41:35,800 EVER HOPED FOR. 2371 01:41:35,800 --> 01:41:40,600 PLASMINOGEN HAS SIGNIFICANT BONE 2372 01:41:40,600 --> 01:41:45,360 LOSS, WHEN YOU CROSS TO THE 2373 01:41:45,360 --> 01:41:46,640 GAMMA, IT BRINGS IT LOWER THAN 2374 01:41:46,640 --> 01:41:48,640 WILD TYPE. 2375 01:41:48,640 --> 01:41:50,080 FOR THOSE WORKING ON PERIODONTAL 2376 01:41:50,080 --> 01:41:51,720 DISEASE IN ANIMAL MODELS WE KNOW 2377 01:41:51,720 --> 01:41:55,320 WITH AGE, THIS IS 24 WEEKS, MICE 2378 01:41:55,320 --> 01:41:57,440 WILL END UP HAVING LOW LEVEL OF 2379 01:41:57,440 --> 01:41:58,960 BONE LOSS. 2380 01:41:58,960 --> 01:42:02,280 IT SEEMS THAT ABROGATING THIS 2381 01:42:02,280 --> 01:42:07,040 BINDING SITE FOR NEUTROPHILS 2382 01:42:07,040 --> 01:42:09,800 RESCUES EVEN IN AGE-DEPENDENT 2383 01:42:09,800 --> 01:42:10,680 PERIODONTAL MODEL INDICATING 2384 01:42:10,680 --> 01:42:19,320 THIS BINDING SITE COULD HAVE 2385 01:42:19,320 --> 01:42:21,720 ROLES INTO COMMON FORMS OF 2386 01:42:21,720 --> 01:42:24,680 PERIODONTAL DISEASE. 2387 01:42:24,680 --> 01:42:26,640 THE CONTROL HERE IS THAT WITHIN 2388 01:42:26,640 --> 01:42:28,720 THIS MOUSE MODEL WHEN WE LOOK IN 2389 01:42:28,720 --> 01:42:30,280 THE TISSUE WE SEE FIBRIN IS 2390 01:42:30,280 --> 01:42:37,800 PRETTY MUCH AT THE SAME LEVEL 2391 01:42:37,800 --> 01:42:39,240 ACCUMULATED AND NEUTROPHIL 2392 01:42:39,240 --> 01:42:41,800 ACCUMULATED WITH PLASMINOGEN 2393 01:42:41,800 --> 01:42:44,040 KNOCKOUT WHICH MEANS THAT, TO 2394 01:42:44,040 --> 01:42:48,320 US, THIS MEANT THAT IT LOOKS 2395 01:42:48,320 --> 01:42:53,120 LIKE YOU NEED INTERACTION 2396 01:42:53,120 --> 01:42:54,440 THROUGH FIB GAMMA. 2397 01:42:54,440 --> 01:42:55,640 IF FIBER AND NEUTROPHILS ARE 2398 01:42:55,640 --> 01:42:58,880 THERE BUT YOU DON'T HAVE 2399 01:42:58,880 --> 01:42:59,920 BINDING, YOU DON'T HAVE DISEASE. 2400 01:42:59,920 --> 01:43:01,800 WE WERE THRILLED WHEN A PAPER 2401 01:43:01,800 --> 01:43:04,120 CAME OUT, A NICE COMMENTARY ON 2402 01:43:04,120 --> 01:43:04,360 IT. 2403 01:43:04,360 --> 01:43:07,160 THE AUTHORS OF THE COMMENTARY 2404 01:43:07,160 --> 01:43:10,440 DID MENTION THIS, THAT UP TO NOW 2405 01:43:10,440 --> 01:43:12,400 WE'VE BEEN THINKING OF 2406 01:43:12,400 --> 01:43:15,480 NEUTROPHIL ACCUMULATION AS A 2407 01:43:15,480 --> 01:43:16,480 SURROGATE FOR IMMUNOPATHOLOGY 2408 01:43:16,480 --> 01:43:19,960 AND THIS WORK IS OPENING THIS 2409 01:43:19,960 --> 01:43:22,920 IDEA THAT NEUTROPHILS ALONE WENT 2410 01:43:22,920 --> 01:43:24,000 LEAD TO NEUROPATHOLOGY, YOU NEED 2411 01:43:24,000 --> 01:43:27,400 A LOCAL TISSUE TRIGGER TO 2412 01:43:27,400 --> 01:43:32,560 STIMULATE THEM INTO MEDIATING A 2413 01:43:32,560 --> 01:43:32,880 PROBLEM. 2414 01:43:32,880 --> 01:43:36,400 NOW, LAKMALI WANTED TO TRY TO 2415 01:43:36,400 --> 01:43:41,280 UNDERSTAND WHAT HAPPENED WHEN 2416 01:43:41,280 --> 01:43:43,080 NEUTROPHILS BIND, IT TOOK HER A 2417 01:43:43,080 --> 01:43:45,040 HUGE EFFORT TO CREATE THIS IN 2418 01:43:45,040 --> 01:43:48,800 VITRO ASSAY AND HAVE IT BE 2419 01:43:48,800 --> 01:43:49,520 CONSISTENTLY REPRODUCIBLE. 2420 01:43:49,520 --> 01:43:52,800 SO WHAT SHE DID IS THAT SHE 2421 01:43:52,800 --> 01:43:55,560 CREATED IN VITRO PLATES, WHERE 2422 01:43:55,560 --> 01:43:58,920 SHE WOULD LAY DOWN AND CROSS 2423 01:43:58,920 --> 01:44:01,680 FIBRIN FROM A WILDTYPE MOUSE OR 2424 01:44:01,680 --> 01:44:07,160 FIB GAMMA MOUSE AND WOULD PLATE 2425 01:44:07,160 --> 01:44:09,440 NEUTROPHILS WITH HUMAN AND MOUSE 2426 01:44:09,440 --> 01:44:12,000 NEUTROPHILS AND ARE COMPARABLE 2427 01:44:12,000 --> 01:44:12,520 RESULTS. 2428 01:44:12,520 --> 01:44:15,960 AND SHE LOOKED AT WHAT HAPPENED 2429 01:44:15,960 --> 01:44:18,960 IN THIS IN VITRO SETTING. 2430 01:44:18,960 --> 01:44:21,280 SHE SAW THE BINDING SITE IS 2431 01:44:21,280 --> 01:44:22,800 IMPORTANT FOR ADHESION SO WHEN 2432 01:44:22,800 --> 01:44:26,000 YOU DON'T HAVE -- WHEN YOU HAVE 2433 01:44:26,000 --> 01:44:27,000 THE MUTATED FIBRIN NEUTROPHILS 2434 01:44:27,000 --> 01:44:28,400 WON'T STICK AS MUCH. 2435 01:44:28,400 --> 01:44:30,600 ALSO WHEN SHE DID DIFFERENT 2436 01:44:30,600 --> 01:44:36,160 LEVELS OF STIMULATION SHE SAW 2437 01:44:36,160 --> 01:44:38,560 THE ACTIVATION OF NEUTROPHILS IS 2438 01:44:38,560 --> 01:44:40,240 GREATLY ENHANCED BECAUSE OF FIT 2439 01:44:40,240 --> 01:44:40,880 GAMMA. 2440 01:44:40,880 --> 01:44:43,200 WHEN YOU DON'T HAVE FIB GAMMA 2441 01:44:43,200 --> 01:44:50,600 YOU HAVE REDUCED ACTIVATION, 2442 01:44:50,600 --> 01:44:51,280 LOSS PRODUCTION. 2443 01:44:51,280 --> 01:44:54,440 IN THE INTEREST OF TIME FOR THIS 2444 01:44:54,440 --> 01:44:56,440 SESSION I'M NOT SHOWING A LOT OF 2445 01:44:56,440 --> 01:44:57,840 DATA AS I SAID THIS IS ALSO 2446 01:44:57,840 --> 01:44:59,840 PUBLISHED, BUT I THOUGHT I WOULD 2447 01:44:59,840 --> 01:45:02,440 SHARE WITH YOU A FASCINATING, IN 2448 01:45:02,440 --> 01:45:05,440 MY OPINION, VIDEO OF SOME ASSAYS 2449 01:45:05,440 --> 01:45:07,040 THAT LAKMALI PUT TOGETHER AND 2450 01:45:07,040 --> 01:45:10,440 THE LEFT-HAND SIDE YOU HAVE THE 2451 01:45:10,440 --> 01:45:12,000 WILDTYPE FIBRIN, ON THE 2452 01:45:12,000 --> 01:45:14,480 RIGHT-HAND SIDE THE KNOCK-IN 2453 01:45:14,480 --> 01:45:14,840 FIBRIN. 2454 01:45:14,840 --> 01:45:17,920 AND SHE GOT TOGETHER WITH A VERY 2455 01:45:17,920 --> 01:45:19,680 TALENTED STAFF SCIENTIST FROM 2456 01:45:19,680 --> 01:45:21,160 OUR CORE FACILITY, ANDREW DOYLE, 2457 01:45:21,160 --> 01:45:25,000 TO FIGURE OUT THESE ASSIST AND 2458 01:45:25,000 --> 01:45:30,520 TO IMAGE AND QUANTIFY. 2459 01:45:30,520 --> 01:45:32,360 THEY ARE STAINING CELLS, 2460 01:45:32,360 --> 01:45:34,320 NEUTROPHILS THROUGH THE NUCLEAR 2461 01:45:34,320 --> 01:45:35,320 STAIN. 2462 01:45:35,320 --> 01:45:38,160 CELLS BECOME GREEN WHEN THEIR 2463 01:45:38,160 --> 01:45:48,320 MEMBRANE ARE STARTING TO DIE, 2464 01:45:48,320 --> 01:45:50,520 RED WHEN NETOSING, AN EXPLOSION 2465 01:45:50,520 --> 01:45:52,280 OF THE CELLS. 2466 01:45:52,280 --> 01:45:55,200 THE CELLS START TO EXPLODE AND 2467 01:45:55,200 --> 01:45:56,960 THIS EXPLOSION MOLD IS MORE 2468 01:45:56,960 --> 01:46:00,160 COMMON ON THE LEFT-HAND SIDE 2469 01:46:00,160 --> 01:46:02,120 VERSUS RIGHT-HAND SIDE, WE'VE 2470 01:46:02,120 --> 01:46:04,080 QUANTIFIED OVER TIME AND HAVE 2471 01:46:04,080 --> 01:46:06,800 DATA FOR THAT BUT IT'S OBVIOUSLY 2472 01:46:06,800 --> 01:46:10,000 VISIBLE EVEN I THINK BY THE 2473 01:46:10,000 --> 01:46:11,520 NAKED EYE HERE. 2474 01:46:11,520 --> 01:46:14,400 THE LAST QUESTION LAKMALI WANTED 2475 01:46:14,400 --> 01:46:18,240 TO ASK, YES, WE HAVE INCREASED 2476 01:46:18,240 --> 01:46:20,840 ACTIVATION AND NETOSIS, IS THIS 2477 01:46:20,840 --> 01:46:24,560 ACTIVATION AND NETOSIS WHAT WILL 2478 01:46:24,560 --> 01:46:26,840 DRIVE PERIODONTAL 2479 01:46:26,840 --> 01:46:28,280 IMMUNOPATHOLOGY? 2480 01:46:28,280 --> 01:46:34,600 DIFFERENT TYPES OF MODELS, TO 2481 01:46:34,600 --> 01:46:37,680 INHIBIT NETOSIS AN WHEN SHE 2482 01:46:37,680 --> 01:46:40,760 INHIBITS IN THE KNOCKOUT MOUSE 2483 01:46:40,760 --> 01:46:41,720 WILL REDUCE IMMUNOPATHOLOGY, 2484 01:46:41,720 --> 01:46:45,320 DOESN'T RESCUE THE T IT WAY 2485 01:46:45,320 --> 01:46:48,960 WHEN SHE ABROGATES FIB GAMMA 2486 01:46:48,960 --> 01:46:50,680 BINDING, AN IMPORTANT PATHWAY 2487 01:46:50,680 --> 01:46:54,080 BUT NOT THE WHOLE STORY HOW FIB 2488 01:46:54,080 --> 01:46:55,120 GAMMA SEEMS TO MEDIATE 2489 01:46:55,120 --> 01:46:55,880 IMMUNOPATHOLOGY SO THERE'S MORE 2490 01:46:55,880 --> 01:46:58,960 FOR US TO UNDERSTAND IN THAT 2491 01:46:58,960 --> 01:47:02,120 ARENA FOR SURE. 2492 01:47:02,120 --> 01:47:04,400 THE WAY -- WE ARE VERY EXCITED 2493 01:47:04,400 --> 01:47:10,200 ABOUT THIS WHEN IT COMES TO 2494 01:47:10,200 --> 01:47:10,800 PLASMINOGEN DEFICIENCY 2495 01:47:10,800 --> 01:47:11,840 ASSOCIATED PERIODONTITIS BUT WE 2496 01:47:11,840 --> 01:47:15,880 WERE ALSO EXCITED AS WE'RE 2497 01:47:15,880 --> 01:47:17,760 THINKING AS A BROADER CONCEPT IN 2498 01:47:17,760 --> 01:47:21,040 BIOLOGY, THE WAY WE'VE BEEN 2499 01:47:21,040 --> 01:47:22,680 THINKING ABOUT THIS IS THAT 2500 01:47:22,680 --> 01:47:25,840 FIBRIN NEEDS TO COME OUT OF THE 2501 01:47:25,840 --> 01:47:28,480 VASCULATURE DURING A WOUND. 2502 01:47:28,480 --> 01:47:30,200 AND TO FORM A CLOT. 2503 01:47:30,200 --> 01:47:33,960 AND IT HAS A BINDING SITE FOR 2504 01:47:33,960 --> 01:47:35,080 NEUTROPHILS BECAUSE WITHIN A 2505 01:47:35,080 --> 01:47:38,160 CLOT THEY NEED TO BE RETAINED 2506 01:47:38,160 --> 01:47:40,560 AND ACTIVATED IN ORDER TO 2507 01:47:40,560 --> 01:47:42,120 MEDIATE ANTIMICROBIAL DEFENSE. 2508 01:47:42,120 --> 01:47:46,680 SO WE THINK OF THIS FIB GAMMA 2509 01:47:46,680 --> 01:47:47,480 NEUTROPHIL BINDING AS 2510 01:47:47,480 --> 01:47:50,640 POTENTIALLY A VERY IMPORTANT 2511 01:47:50,640 --> 01:47:52,480 PATHWAY FOR WOUND CLEARANCE AND 2512 01:47:52,480 --> 01:47:54,600 WOUND HEALING. 2513 01:47:54,600 --> 01:47:56,440 AND EVENTUALLY, AS THE WOUND IS 2514 01:47:56,440 --> 01:48:00,240 CLEARED, THEN FIBRIN CAN BE 2515 01:48:00,240 --> 01:48:01,680 REMOVED BY PLASMINOGEN AND 2516 01:48:01,680 --> 01:48:03,520 COMPLETE WOUND HEALING CAN 2517 01:48:03,520 --> 01:48:04,400 OCCUR. 2518 01:48:04,400 --> 01:48:06,720 HOWEVER, IF YOU DON'T HAVE 2519 01:48:06,720 --> 01:48:08,760 PLASMINOGEN, WHEN THIS 2520 01:48:08,760 --> 01:48:11,680 ACCUMULATION OF FIBRIN PERSISTS, 2521 01:48:11,680 --> 01:48:13,160 NEUTROPHIL ACTIVATIONS PERSISTS, 2522 01:48:13,160 --> 01:48:15,400 AND THEN YOU DON'T -- YOU HAVE 2523 01:48:15,400 --> 01:48:17,280 CHRONIC INFLAMMATION AND YOU 2524 01:48:17,280 --> 01:48:18,720 DON'T HAVE WOUND HEALING. 2525 01:48:18,720 --> 01:48:22,040 IN MANY WAYS WE THINK OF THE 2526 01:48:22,040 --> 01:48:23,600 PERIODONTAL TISSUES OF 2527 01:48:23,600 --> 01:48:24,440 CONTINUOUSLY STIMULATED 2528 01:48:24,440 --> 01:48:25,880 ENVIRONMENT THAT NEED WOUND 2529 01:48:25,880 --> 01:48:29,720 HEALING AND BECOMES IMPAIRED 2530 01:48:29,720 --> 01:48:37,640 WHEN YOU DON'T HAVE 2531 01:48:37,640 --> 01:48:38,120 FIBRINOLYSIS. 2532 01:48:38,120 --> 01:48:39,720 WE SUSPECT THIS COULD BE 2533 01:48:39,720 --> 01:48:40,280 IMPORTANT IN WOUND HEALING, 2534 01:48:40,280 --> 01:48:42,240 WANTED TO THINK ABOUT THE 2535 01:48:42,240 --> 01:48:44,560 CONTEXT OF COMMON FORMS OF 2536 01:48:44,560 --> 01:48:45,080 PERIODONTITIS. 2537 01:48:45,080 --> 01:48:46,400 AND SO THE REASON THIS MADE 2538 01:48:46,400 --> 01:48:48,920 SENSE FOR US TO THINK OF IN THE 2539 01:48:48,920 --> 01:48:51,360 CONTEXT OF COMMON FORMS OF 2540 01:48:51,360 --> 01:48:54,040 PERIODONTITIS WE ALREADY KNEW BY 2541 01:48:54,040 --> 01:48:56,640 WORK OF MANY BEFORE US IN THE 2542 01:48:56,640 --> 01:48:58,640 FIELD THAT ESPECIALLY IN THE 2543 01:48:58,640 --> 01:49:02,720 YOUNGER ADULT KIND OF SETTINGS 2544 01:49:02,720 --> 01:49:04,440 OF PERIODONTITIS, NEUTROPHILS 2545 01:49:04,440 --> 01:49:08,520 ARE A DOMINANT CELL TYPE. 2546 01:49:08,520 --> 01:49:10,600 THIS IDEA NEUTROPHILS PLAY AN 2547 01:49:10,600 --> 01:49:14,320 IMPORTANT ROLE IN PERIODONTITIS 2548 01:49:14,320 --> 01:49:16,840 WE WERE NOT THE FIRST TO 2549 01:49:16,840 --> 01:49:20,000 INTRODUCE BUT DISTHIS DIS-- BUT 2550 01:49:20,000 --> 01:49:24,120 THIS IS DATA FROM OUR LAB BY 2551 01:49:24,120 --> 01:49:27,240 FLOW CYTOMETRY AND HISTOLOGY. 2552 01:49:27,240 --> 01:49:31,920 WE ALSO SEE THAT NEUTROPHILS ARE 2553 01:49:31,920 --> 01:49:33,120 IN AREAS CONSISTENT WITH FIBRIN. 2554 01:49:33,120 --> 01:49:38,720 THOSE OF US THAT WORK WITH THESE 2555 01:49:38,720 --> 01:49:41,560 PATIENTS CLINICALLY KNOW 2556 01:49:41,560 --> 01:49:42,880 BLEEDING, VASCULAR LEAKAGE, EVEN 2557 01:49:42,880 --> 01:49:53,400 SEVERE BLEEDING IS A HALLMARK OF 2558 01:49:54,480 --> 01:49:54,840 PERIODONTITIS. 2559 01:49:54,840 --> 01:49:57,360 AS WE WERE PUTTING OUR DATA 2560 01:49:57,360 --> 01:50:00,200 TOGETHER, A GROUP FROM GERMANY 2561 01:50:00,200 --> 01:50:03,640 PUBLISHED A LARGE GWAS STUDY OFY 2562 01:50:03,640 --> 01:50:10,080 ON WHAT WAS THEN CALLED 2563 01:50:10,080 --> 01:50:11,920 AGGRESSIVE PERIODONTITIS. 2564 01:50:11,920 --> 01:50:15,080 THEY SHOWED THE GENE VARIANT 2565 01:50:15,080 --> 01:50:17,720 THAT HAD A VARIATION MORE 2566 01:50:17,720 --> 01:50:20,120 SIGNIFICANTLY ASSOCIATED WITH 2567 01:50:20,120 --> 01:50:22,720 AGGRESSIVE FORMS OF 2568 01:50:22,720 --> 01:50:23,880 PERIODONTITIS WAS INDEED 2569 01:50:23,880 --> 01:50:24,160 PLASMINOGEN. 2570 01:50:24,160 --> 01:50:26,960 THIS WAS EXCITING TO US. 2571 01:50:26,960 --> 01:50:31,000 WE GOT TOGETHER WITH A COLLEAGUE 2572 01:50:31,000 --> 01:50:34,800 IN FRANCE, WHO WORKS ON GENOMIC 2573 01:50:34,800 --> 01:50:37,840 DATASETS, AND IN ORAL DISEASES, 2574 01:50:37,840 --> 01:50:42,920 AND HE HAD BEEN WORKING ON GWAS 2575 01:50:42,920 --> 01:50:44,680 STUDY OF PERIODONTITIS IN THE 2576 01:50:44,680 --> 01:50:48,280 U.S. AND WE THOUGHT WE ALREADY 2577 01:50:48,280 --> 01:50:49,560 HAVE SEEN THIS FASCINATING DATA 2578 01:50:49,560 --> 01:50:50,800 FROM THE GERMAN GROUP, CAN WE 2579 01:50:50,800 --> 01:50:53,960 LOOK AT THE DATA FROM THE U.S. 2580 01:50:53,960 --> 01:50:55,960 POPULATION AND SEE IF WE FIND 2581 01:50:55,960 --> 01:50:57,560 SOMETHING SIMILAR. 2582 01:50:57,560 --> 01:51:01,120 FROM THE U.S. POPULATION THE 2583 01:51:01,120 --> 01:51:02,960 SEVERE PERIODONTITIS SUBGROUP 2584 01:51:02,960 --> 01:51:06,000 WAS NOT A LARGE -- DIDN'T HAVE A 2585 01:51:06,000 --> 01:51:08,400 LARGE NUMBER SO WE WEREN'T TO DO 2586 01:51:08,400 --> 01:51:10,520 GWAS LEVEL ANALYSIS, WE HAD TO 2587 01:51:10,520 --> 01:51:13,800 DO A TARGETED GENE LOOKUP. 2588 01:51:13,800 --> 01:51:18,080 WHEN KIMON DID THIS EVALUATION 2589 01:51:18,080 --> 01:51:22,000 WHAT HE FOUND THERE IS 2590 01:51:22,000 --> 01:51:23,760 SIGNIFICANT ASSOCIATION BETWEEN 2591 01:51:23,760 --> 01:51:30,560 SNPs IN THE PLASMINOGEN REGION 2592 01:51:30,560 --> 01:51:32,160 WITH SEVERE FORMS OF PERIODONTAL 2593 01:51:32,160 --> 01:51:34,360 DISEASE AND ASSOCIATED WITH 2594 01:51:34,360 --> 01:51:35,120 YOUNGER ADULTS CONSISTENT WITH 2595 01:51:35,120 --> 01:51:37,880 DATA FROM THE GERMAN GROUP. 2596 01:51:37,880 --> 01:51:39,960 THIS IS JUST AN ASSOCIATION, IT 2597 01:51:39,960 --> 01:51:42,440 DOESN'T PROVE CAUSALITY AT THIS 2598 01:51:42,440 --> 01:51:45,440 POINT BUT OPENS THE DOOR THAT 2599 01:51:45,440 --> 01:51:48,360 PLASMINOGEN VARIATION COULD BE 2600 01:51:48,360 --> 01:51:52,440 PLAYING A ROLE THROUGH FIBRIN IN 2601 01:51:52,440 --> 01:51:54,920 SOME FORMS OF COMMON 2602 01:51:54,920 --> 01:51:55,400 PERIODONTITIS. 2603 01:51:55,400 --> 01:51:57,520 THE WAY WE'VE BEEN WANTING TO 2604 01:51:57,520 --> 01:52:00,160 LOOK IN THIS, IN THE FUTURE, IS 2605 01:52:00,160 --> 01:52:02,240 THAT WHEN WE START WITH 2606 01:52:02,240 --> 01:52:04,160 MENDELIAN DISEASE WE FIND 2607 01:52:04,160 --> 01:52:07,640 PATHWAYS THAT INDEED SEEM TO BE 2608 01:52:07,640 --> 01:52:10,960 IMPORTANT IN PERIODONTAL 2609 01:52:10,960 --> 01:52:11,760 STABILITY AND IMMUNOPATHOLOGY. 2610 01:52:11,760 --> 01:52:14,080 WHILE WE HAVE WAYS TO TRY TO 2611 01:52:14,080 --> 01:52:15,600 UNDERSTAND MECHANISMS FOR THOSE 2612 01:52:15,600 --> 01:52:18,040 DISEASES WE WANT TO TAKE IT A 2613 01:52:18,040 --> 01:52:19,280 STEP FURTHER AND POTENTIALLY 2614 01:52:19,280 --> 01:52:20,760 LOOK INTO THE COMMON DISEASES 2615 01:52:20,760 --> 01:52:26,240 AND SEE IF THIS COULD DESCRIBE 2616 01:52:26,240 --> 01:52:30,000 AT LEAST A SUBPOPULATION OF 2617 01:52:30,000 --> 01:52:32,120 PATIENTS WITH PERIODONTITIS, A 2618 01:52:32,120 --> 01:52:35,360 LOT OF INFLAMMATORY DISEASE, 2619 01:52:35,360 --> 01:52:38,960 ARTHRITIS, IMMUNE DISEASES, DO 2620 01:52:38,960 --> 01:52:40,360 END UP HAVING SOME 2621 01:52:40,360 --> 01:52:41,680 SPECIFICATION, THEY HAVE 2622 01:52:41,680 --> 01:52:45,400 CLINICAL PHENOTYPES THAT ARE 2623 01:52:45,400 --> 01:52:48,600 SHARED BUT THE GENETIC 2624 01:52:48,600 --> 01:52:49,560 SUSCEPTIBILITY AND PATHWAYS MAY 2625 01:52:49,560 --> 01:52:51,400 NOT BE SHARED BY ALL AND 2626 01:52:51,400 --> 01:52:53,680 TARGETED TREATMENTS MAY NOT WORK 2627 01:52:53,680 --> 01:52:57,920 IN THE SAME UNTIL WE UNDERSTAND 2628 01:52:57,920 --> 01:52:59,240 THE PATHOPHYSIOLOGY INVOLVED IN 2629 01:52:59,240 --> 01:52:59,840 THE SUBGROUPS. 2630 01:52:59,840 --> 01:53:02,880 AND SO I WILL LEAVE YOU WITH 2631 01:53:02,880 --> 01:53:07,120 THIS IDEA THAT WHAT I'M HOPING 2632 01:53:07,120 --> 01:53:08,800 THIS WORK FROM LAKMALI HAS 2633 01:53:08,800 --> 01:53:12,640 ATTEMPTED TO DO, WE HOPE CAN 2634 01:53:12,640 --> 01:53:15,480 MOVE FORWARD IS THAT WE WANT TO 2635 01:53:15,480 --> 01:53:18,640 TAKE A UNIQUE LENS AT THE NIH 2636 01:53:18,640 --> 01:53:20,520 WITH GENETIC IMMUNODEFICIENCY TO 2637 01:53:20,520 --> 01:53:21,920 UNDERSTAND HUMAN BIOLOGY AS 2638 01:53:21,920 --> 01:53:25,960 RELATES TO ORAL IMMUNITY AND 2639 01:53:25,960 --> 01:53:27,720 PERIODONTAL IMMUNOPATHOLOGY, TRY 2640 01:53:27,720 --> 01:53:29,480 TO FOCUS ON GENETIC DISEASE AND 2641 01:53:29,480 --> 01:53:31,760 TRY TO HELP PATIENTS THAT HAVE 2642 01:53:31,760 --> 01:53:34,400 DISEASES THAT ARE HARD TO MANAGE 2643 01:53:34,400 --> 01:53:37,560 ELSEWHERE, BUT ALSO OPEN THE 2644 01:53:37,560 --> 01:53:43,360 WINDOW INTO UNDERSTANDING 2645 01:53:43,360 --> 01:53:45,000 POTENTIALLY COMMON FORMS OF 2646 01:53:45,000 --> 01:53:45,360 PERIODONTITIS. 2647 01:53:45,360 --> 01:53:47,320 IT'S BEEN MY GROUP IN THE LAST 2648 01:53:47,320 --> 01:53:51,080 DECADE, A GROUP OF VERY TALENTED 2649 01:53:51,080 --> 01:53:53,120 DEVOTED FANTASTIC PEOPLE, I 2650 01:53:53,120 --> 01:53:55,560 TALKED ABOUT LAKMALI'S WORK THE 2651 01:53:55,560 --> 01:53:58,640 MOST TODAY BUT I'M SORRY I 2652 01:53:58,640 --> 01:54:00,240 COULDN'T MENTION EVERYBODY'S 2653 01:54:00,240 --> 01:54:00,560 WORK. 2654 01:54:00,560 --> 01:54:02,960 AND IT'S A DIVERSE GROUP OF 2655 01:54:02,960 --> 01:54:04,480 INDIVIDUALS FROM ALL PARTS OF 2656 01:54:04,480 --> 01:54:06,240 THE WORLD WITH CLINICAL AND 2657 01:54:06,240 --> 01:54:08,680 BASIC BACKGROUNDS AND I REALLY 2658 01:54:08,680 --> 01:54:10,080 HAVE BEEN PRIVILEGED TO BE 2659 01:54:10,080 --> 01:54:11,400 MENTORING AND WORKING WITH THEM 2660 01:54:11,400 --> 01:54:13,560 OVER THE YEARS. 2661 01:54:13,560 --> 01:54:15,320 BUT OF COURSE THIS WORK DOESN'T 2662 01:54:15,320 --> 01:54:17,680 HAPPEN FROM ONE LAB. 2663 01:54:17,680 --> 01:54:20,160 IT COMES TOGETHER WITH 2664 01:54:20,160 --> 01:54:22,440 COLLABORATIONS FROM THE NIH 2665 01:54:22,440 --> 01:54:25,720 HOSPITAL, INTRAMURAL PROGRAM, A 2666 01:54:25,720 --> 01:54:27,440 LOT OF EXTRAMURAL COLLABORATORS, 2667 01:54:27,440 --> 01:54:32,480 OF COURSE GENEROUS SUPPORT FROM 2668 01:54:32,480 --> 01:54:33,040 LEADERSHIP. 2669 01:54:33,040 --> 01:54:35,000 THANK YOU VERY MUCH FOR YOUR 2670 01:54:35,000 --> 01:54:38,200 ATTENTION. 2671 01:54:38,200 --> 01:54:45,120 >> THANK YOU VERY MUCH, NIKI. 2672 01:54:45,120 --> 01:54:48,280 OH, RENA. 2673 01:54:48,280 --> 01:54:49,520 >> WE'RE BACK. 2674 01:54:49,520 --> 01:54:53,120 ANY QUESTIONS FROM COUNCIL OR 2675 01:54:53,120 --> 01:54:53,440 PARTICIPANTS? 2676 01:54:53,440 --> 01:54:55,160 WHAT A WONDERFUL PRESENTATION. 2677 01:54:55,160 --> 01:54:57,160 WHAT A WONDERFUL JOURNEY YOU 2678 01:54:57,160 --> 01:54:58,360 WERE ON, NIKI. 2679 01:54:58,360 --> 01:55:02,280 SO HAPPY AND PROUD OF WHERE 2680 01:55:02,280 --> 01:55:06,440 YOU'VE COME IN UNRAVELING 2681 01:55:06,440 --> 01:55:08,520 UNDERLYING MOLECULAR QUESTION. 2682 01:55:08,520 --> 01:55:11,400 WOULD YOU NOT SUSPECT A 2683 01:55:11,400 --> 01:55:14,520 MULTI-GENIC CONTRIBUTION TO THIS 2684 01:55:14,520 --> 01:55:15,240 COMPLEX DISEASE? 2685 01:55:15,240 --> 01:55:18,480 >> YES, SO, YES, THAT MAKES IT A 2686 01:55:18,480 --> 01:55:20,000 LOT MORE COMPLICATED. 2687 01:55:20,000 --> 01:55:24,200 HOWEVER, IF WE DO END UP HAVING 2688 01:55:24,200 --> 01:55:27,240 SUBCATEGORIES OF PATIENTS WHERE 2689 01:55:27,240 --> 01:55:30,200 WE CAN ZERO IN, ON A GENE 2690 01:55:30,200 --> 01:55:33,360 VARIATION THAT COULD BE 2691 01:55:33,360 --> 01:55:34,800 PRIMARILY IMPORTANT, THAT COULD 2692 01:55:34,800 --> 01:55:37,760 ALSO UNTIE YOUR HANDS A LITTLE 2693 01:55:37,760 --> 01:55:38,040 BIT. 2694 01:55:38,040 --> 01:55:38,280 >> YES. 2695 01:55:38,280 --> 01:55:42,480 >> THE OTHER PART IS AS WE THINK 2696 01:55:42,480 --> 01:55:44,720 OF COMBINED KIND OF PATHWAYS 2697 01:55:44,720 --> 01:55:46,600 THAT WILL FEED INTO A PROBLEM, 2698 01:55:46,600 --> 01:55:52,320 IF WE CAN GET NODES THAT ARE THE 2699 01:55:52,320 --> 01:55:54,840 MOST IMPORTANT TO TARGET. 2700 01:55:54,840 --> 01:55:57,520 I DEFINITELY DON'T HAVE MOST OF 2701 01:55:57,520 --> 01:56:04,720 THE ANSWERS. 2702 01:56:04,720 --> 01:56:06,360 >> THANK YOU. 2703 01:56:06,360 --> 01:56:06,800 JACQUES? 2704 01:56:06,800 --> 01:56:08,920 >> TERRIFIC PRESENTATION, GREAT 2705 01:56:08,920 --> 01:56:09,120 WORK. 2706 01:56:09,120 --> 01:56:11,440 A QUESTION IN TERMS OF ANY 2707 01:56:11,440 --> 01:56:14,400 THOUGHTS YOU MIGHT HAVE IN TERMS 2708 01:56:14,400 --> 01:56:18,080 OF TARGETING LOCALLY THE 2709 01:56:18,080 --> 01:56:19,120 PLASMINOGEN PATHWAY IN PATIENTS 2710 01:56:19,120 --> 01:56:20,440 WITH PERIODONTAL DISEASE. 2711 01:56:20,440 --> 01:56:23,040 >> YES, I'LL TELL YOU TWO OR 2712 01:56:23,040 --> 01:56:23,720 THREE THINGS. 2713 01:56:23,720 --> 01:56:28,840 WHEN I I GAVE A SIMILAR TALK 2714 01:56:28,840 --> 01:56:33,480 WITH SOME OTHER PARTS, NIH 2715 01:56:33,480 --> 01:56:35,000 AUDIENCE, SO ONE LOCAL 2716 01:56:35,000 --> 01:56:37,000 PLASMINOGEN WOULD BE MORE FIBRIN 2717 01:56:37,000 --> 01:56:39,920 ACCUMULATION RATHER THAN 2718 01:56:39,920 --> 01:56:41,160 PLASMINOGEN THINKING OF 2719 01:56:41,160 --> 01:56:43,120 DEFICIENCY, WANT SOMETHING THAT 2720 01:56:43,120 --> 01:56:48,160 LEADS TO FIBRINOLYSIS. 2721 01:56:48,160 --> 01:56:52,200 WE'RE INTERESTED IN FIBRIN SHOWN 2722 01:56:52,200 --> 01:56:57,440 TO PLAY A ROLE IN BRAIN KIND OF 2723 01:56:57,440 --> 01:56:58,720 MICROGLIAL ACTIVATION, IN THE 2724 01:56:58,720 --> 01:57:00,400 SETTING OF BRAIN INJURY, WHEN 2725 01:57:00,400 --> 01:57:03,200 THE BRAIN BARRIER IS BREACHED IT 2726 01:57:03,200 --> 01:57:05,080 ACCUMULATES AND SEEMS TO BE 2727 01:57:05,080 --> 01:57:06,160 AFFECTING OF IMMUNITY IN THE 2728 01:57:06,160 --> 01:57:07,720 BRAIN SO THE PERSON THAT'S BEEN 2729 01:57:07,720 --> 01:57:12,000 WORKING ON THAT HAS COME UP WITH 2730 01:57:12,000 --> 01:57:13,560 THE FIB GAMMA BINDING ANTIBODY. 2731 01:57:13,560 --> 01:57:16,720 AND THEY ARE TRYING TO MOVE THAT 2732 01:57:16,720 --> 01:57:20,800 THROUGH, IT HASN'T GONE INTO 2733 01:57:20,800 --> 01:57:23,480 PRE-CLINICAL PHASE, WE WANT TO 2734 01:57:23,480 --> 01:57:26,480 TRY THAT IN PERIODONTAL MODELS. 2735 01:57:26,480 --> 01:57:27,560 NOW, LOCAL VERSUS SYSTEMIC 2736 01:57:27,560 --> 01:57:30,200 THERE'S GOING TO BE INTERESTING, 2737 01:57:30,200 --> 01:57:34,640 ONE THING, YEAH, SO WE'RE 2738 01:57:34,640 --> 01:57:36,400 THINKING ALONG THOSE LINES BUT 2739 01:57:36,400 --> 01:57:40,520 IDEALLY WE WOULD WANT TO 2740 01:57:40,520 --> 01:57:42,920 SUBSTRATIFY PATIENTS THAT HAVE 2741 01:57:42,920 --> 01:57:44,120 PLASMINOGEN VARIATIONS AND SEE 2742 01:57:44,120 --> 01:57:46,000 WHETHER VARIATIONS EVEN HAVE A 2743 01:57:46,000 --> 01:57:47,320 FUNCTIONAL OUTCOME SO AT THIS 2744 01:57:47,320 --> 01:57:48,840 POINT FOR THE GENERAL POPULATION 2745 01:57:48,840 --> 01:57:52,560 WE DON'T EVEN KNOW IF SNPs 2746 01:57:52,560 --> 01:57:55,080 HAVE AN OUTCOME IN REDUCE THE 2747 01:57:55,080 --> 01:57:56,400 PLASMINOGEN AND THAT'S WHAT WE 2748 01:57:56,400 --> 01:57:57,920 WANT TO COME TOGETHER WITH MANY 2749 01:57:57,920 --> 01:58:00,000 IN THE EXTRAMURAL COMMUNITY TO 2750 01:58:00,000 --> 01:58:02,840 THINK ABOUT AND THEN MOVE INTO 2751 01:58:02,840 --> 01:58:05,320 THINKING OF TARGETING. 2752 01:58:05,320 --> 01:58:06,760 >> THANK YOU, NIKI. 2753 01:58:06,760 --> 01:58:07,720 MATT HAS A QUESTION. 2754 01:58:07,720 --> 01:58:09,840 >> I WAS INTERESTED IN THE 2755 01:58:09,840 --> 01:58:11,920 MICROBIOME COMPONENT. 2756 01:58:11,920 --> 01:58:14,920 IS THERE ANY INTERACTION WITH 2757 01:58:14,920 --> 01:58:15,760 SPECIFIC PERIODONTAL PATHOGENS 2758 01:58:15,760 --> 01:58:23,320 WITH EITHER OF THE NEUTROPHIL OR 2759 01:58:23,320 --> 01:58:23,880 FIBRIN? 2760 01:58:23,880 --> 01:58:25,840 >> SO, WHAT I WILL TELL YOU IN 2761 01:58:25,840 --> 01:58:27,480 GERM-FREE MICE WE DON'T HAVE 2762 01:58:27,480 --> 01:58:29,120 FIBRIN ACCUMULATION SO WE 2763 01:58:29,120 --> 01:58:34,680 KNOW -- THE FACT THAT ALL OF THE 2764 01:58:34,680 --> 01:58:35,920 DOMINANT PHENOTYPE OF MUCOSAL 2765 01:58:35,920 --> 01:58:41,080 SUGGESTS THAT SOMETHING THAT IS 2766 01:58:41,080 --> 01:58:44,880 IN THE MUSE CO-A MICROBIOME, 2767 01:58:44,880 --> 01:58:49,000 PLASMINOGEN MICE GERM FREE AND 2768 01:58:49,000 --> 01:58:58,320 SAW THAT THEY HAVE REDUCED 2769 01:58:58,320 --> 01:59:00,080 FIBRIN ACCUMULATION WHETHER THAT 2770 01:59:00,080 --> 01:59:01,480 LEADS TO LEAKAGE I CAN'T TELL 2771 01:59:01,480 --> 01:59:01,640 YOU. 2772 01:59:01,640 --> 01:59:07,440 THERE IS DATA TO SUPPORT FIBRIN 2773 01:59:07,440 --> 01:59:08,560 MESHES BECOME STICKY FOR 2774 01:59:08,560 --> 01:59:09,840 PARTICULAR MICROBES, IF THEY ARE 2775 01:59:09,840 --> 01:59:12,960 AROUND TOO LONG WHETHER THAT 2776 01:59:12,960 --> 01:59:14,840 PERPETUATES -- THERE'S A LOT TO 2777 01:59:14,840 --> 01:59:15,160 BE ANSWERED. 2778 01:59:15,160 --> 01:59:18,560 AND SO SOME OF THESE QUESTIONS 2779 01:59:18,560 --> 01:59:20,760 LAKMALI HAS GOTTEN A K99 FROM 2780 01:59:20,760 --> 01:59:23,200 AND WE'RE VERY PROUD SO SOME 2781 01:59:23,200 --> 01:59:24,480 QUESTIONS SHE WILL BE TAKING 2782 01:59:24,480 --> 01:59:26,000 WITH HER, A BUNCH OF QUESTIONS 2783 01:59:26,000 --> 01:59:31,720 FOR HER TO BE LOOKING AT. 2784 01:59:31,720 --> 01:59:32,080 >> WONDERFUL. 2785 01:59:32,080 --> 01:59:32,400 I THINK -- 2786 01:59:32,400 --> 01:59:37,160 >> I HAVE A QUESTION. 2787 01:59:37,160 --> 01:59:38,480 >> KATHY, YES. 2788 01:59:38,480 --> 01:59:41,560 >> I WAS WONDERING IN TERMS OF 2789 01:59:41,560 --> 01:59:42,480 THINKING ABOUT MECHANISMS 2790 01:59:42,480 --> 01:59:44,960 WONDERFUL TALK, BY THE WAY. 2791 01:59:44,960 --> 01:59:47,480 DO THESE PATIENTS HAVE PAIN? 2792 01:59:47,480 --> 01:59:49,800 DO YOU EVER ASSESS PAIN? 2793 01:59:49,800 --> 01:59:53,400 AND DOES THAT CORRELATE WITH ANY 2794 01:59:53,400 --> 02:00:03,880 KIND OF -- THE LEVEL OF THE 2795 02:00:05,960 --> 02:00:06,160 CONDITION. 2796 02:00:06,160 --> 02:00:07,200 >> PERIODONTITIS IS NOT 2797 02:00:07,200 --> 02:00:09,600 ASSOCIATED WITH PAIN. 2798 02:00:09,600 --> 02:00:11,040 PATIENTS COME TO A DENTIST 2799 02:00:11,040 --> 02:00:14,880 VOLUNTARILY BECAUSE OF PAIN SO 2800 02:00:14,880 --> 02:00:17,160 MANY TIMES PATIENTS WITH 2801 02:00:17,160 --> 02:00:17,920 PERIODONTITIS GO UNCHECKED 2802 02:00:17,920 --> 02:00:21,960 BECAUSE UNTIL BLEEDING IS A 2803 02:00:21,960 --> 02:00:23,040 SYMPTOM, SWELLING, PEOPLE TEND 2804 02:00:23,040 --> 02:00:25,960 TO IGNORE THAT, PAIN IS NOT A 2805 02:00:25,960 --> 02:00:27,080 DOMINANT PHENOTYPE OR CLINICAL 2806 02:00:27,080 --> 02:00:32,000 SIGN FOR PERIODONTITIS UNLESS 2807 02:00:32,000 --> 02:00:35,600 YOU GET AN ABSCESS. 2808 02:00:35,600 --> 02:00:36,560 WE SEE PATIENTS LATE SOMETIMES 2809 02:00:36,560 --> 02:00:36,920 BECAUSE OF THAT. 2810 02:00:36,920 --> 02:00:38,520 I DON'T KNOW IF THAT ANSWERS 2811 02:00:38,520 --> 02:00:40,280 YOUR QUESTION. 2812 02:00:40,280 --> 02:00:42,360 >> I ASKED BECAUSE THE 2813 02:00:42,360 --> 02:00:43,560 PLASMINOGEN PATHWAY IN GENERAL 2814 02:00:43,560 --> 02:00:45,000 IS IMPORTANT IN SENSORY NEURONS 2815 02:00:45,000 --> 02:00:47,000 AS WELL AND SO THERE MIGHT BE A 2816 02:00:47,000 --> 02:00:48,680 WAY TO STRATIFY. 2817 02:00:48,680 --> 02:00:49,760 >> WITH A PATIENT WITH 2818 02:00:49,760 --> 02:00:52,280 PLASMINOGEN I CANNOT ANSWER THAT 2819 02:00:52,280 --> 02:00:52,960 QUESTION. 2820 02:00:52,960 --> 02:00:57,600 I WAS ANSWERING IN GENERAL FOR 2821 02:00:57,600 --> 02:00:58,600 PERIODONTITIS BUT I HAVEN'T SEEN 2822 02:00:58,600 --> 02:00:59,400 THAT REPORTED. 2823 02:00:59,400 --> 02:01:01,200 WE'VE ONLY SEEN ONE OF THESE 2824 02:01:01,200 --> 02:01:05,000 PATIENTS AT NIH. 2825 02:01:05,000 --> 02:01:05,920 >> THANK YOU. 2826 02:01:05,920 --> 02:01:08,000 >> PERIPHERAL CENTRAL 2827 02:01:08,000 --> 02:01:08,320 CONNECTIONS. 2828 02:01:08,320 --> 02:01:09,440 WELL, THANK YOU, NIKI, FOR THE 2829 02:01:09,440 --> 02:01:12,520 TIME AND SHARING YOUR KNOWLEDGE 2830 02:01:12,520 --> 02:01:13,560 AND PROGRESS WITH US. 2831 02:01:13,560 --> 02:01:14,240 THANK YOU. 2832 02:01:14,240 --> 02:01:16,440 >> THANK YOU FOR HAVING ME. 2833 02:01:16,440 --> 02:01:19,080 >> LOVELY DOING THAT. 2834 02:01:19,080 --> 02:01:20,360 FOLKS, DOES ANYONE NEED A 2835 02:01:20,360 --> 02:01:22,560 BIO-BREAK, A QUICK ONE, COFFEE, 2836 02:01:22,560 --> 02:01:25,320 ANYTHING LIKE THAT? 2837 02:01:25,320 --> 02:01:29,560 WE WERE NOT A SUBJECT OF CYBER 2838 02:01:29,560 --> 02:01:29,800 ATTACK. 2839 02:01:29,800 --> 02:01:30,760 INTERNET CAPABILITY SIMPLY WAS 2840 02:01:30,760 --> 02:01:32,840 NOT EXISTENT IN THE ENTIRE 2841 02:01:32,840 --> 02:01:33,800 BUILDING 31. 2842 02:01:33,800 --> 02:01:34,360 NOW IT'S RESTORED. 2843 02:01:34,360 --> 02:01:40,400 WE SHOULD BE BACK ON SCHEDULE. 2844 02:01:40,400 --> 02:01:42,320 SHOULD I LAUNCH STRAIGHT INTO MY 2845 02:01:42,320 --> 02:01:43,040 -- 2846 02:01:43,040 --> 02:01:47,520 >> WE CAN DO A 5-MINUTE BREAK. 2847 02:01:47,520 --> 02:01:48,960 >> HOW DID LARRY -- WE WERE 2848 02:01:48,960 --> 02:01:50,080 KICKED OUT, HE WAS IN THE MIDST 2849 02:01:50,080 --> 02:01:52,000 OF Q&A. 2850 02:01:52,000 --> 02:01:54,720 DID HE TALK ABOUT ANYTHING ELSE? 2851 02:01:54,720 --> 02:01:57,040 WAS IT -- I LEFT OFF WHEN THE OF 2852 02:01:57,040 --> 02:02:03,080 HE WAS TALKING ABOUT THE NEW 2853 02:02:03,080 --> 02:02:03,360 DIRECTOR. 2854 02:02:03,360 --> 02:02:08,560 WAS IT ARPA-H? 2855 02:02:08,560 --> 02:02:11,200 >> ARPA RELATED, ARPA I AND ARPA 2856 02:02:11,200 --> 02:02:11,320 E. 2857 02:02:11,320 --> 02:02:11,600 >> GREAT. 2858 02:02:11,600 --> 02:02:13,480 WE SHOULD BE BACK IN FIVE 2859 02:02:13,480 --> 02:02:13,720 MINUTES. 2860 02:02:13,720 --> 02:02:16,800 >> FIVE MINUTES AND WE'LL THEN 2861 02:02:16,800 --> 02:02:18,120 HAVE YOUR DIRECTOR'S REPORT. 2862 02:02:18,120 --> 02:02:19,120 >> PLEASE DO COME BACK. 2863 02:02:19,120 --> 02:02:23,640 THANKS. 2864 02:02:23,640 --> 02:02:25,360 >> FROM NIKI'S TALK WE'VE 2865 02:02:25,360 --> 02:02:26,360 LEARNED TO UNDERSTAND MOLECULAR 2866 02:02:26,360 --> 02:02:27,880 PATHOGENESIS OF THE DISEASE THAT 2867 02:02:27,880 --> 02:02:33,000 IS REALLY A PUBLIC HEALTH 2868 02:02:33,000 --> 02:02:37,400 CONCERN, HUGE BURDEN ON SOCIETY, 2869 02:02:37,400 --> 02:02:40,280 UNDERSTANDING SYSTEMS APPROACH 2870 02:02:40,280 --> 02:02:41,000 IS VALUABLE. 2871 02:02:41,000 --> 02:02:44,280 THAT IS A THEME THAT'S GOING TO 2872 02:02:44,280 --> 02:02:46,040 RESONATE THROUGH THIS TALK, I 2873 02:02:46,040 --> 02:02:47,800 THINK LARRY EMPHASIZED TO THE 2874 02:02:47,800 --> 02:02:50,240 DEVELOPMENT OF ARPA-H AND ALL 2875 02:02:50,240 --> 02:02:52,720 THE OTHER ALPHABET MODELS THAT 2876 02:02:52,720 --> 02:02:54,400 THE AGE OF INTEGRATION OF 2877 02:02:54,400 --> 02:02:57,440 CONNECTING THE DOTS IS UPON US. 2878 02:02:57,440 --> 02:03:02,240 AND WE NO LONGER CAN STAY 2879 02:03:02,240 --> 02:03:03,240 ISOLATED IN ECOSYSTEMS THAT 2880 02:03:03,240 --> 02:03:04,480 DON'T CONNECT. 2881 02:03:04,480 --> 02:03:06,160 I'VE BEEN IMMERSED IN THAT KIND 2882 02:03:06,160 --> 02:03:07,600 OF THINKING SINCE LAST COUNCIL, 2883 02:03:07,600 --> 02:03:13,840 SO THIS IS GOING TO REFLECT 2884 02:03:13,840 --> 02:03:14,760 THAT. 2885 02:03:14,760 --> 02:03:15,760 WE'VE APPROACHING OUR 75th 2886 02:03:15,760 --> 02:03:21,080 YEAR, WE HAVE A PLANNING 2887 02:03:21,080 --> 02:03:22,400 COMMITTEE OF HISTORIANS AND 2888 02:03:22,400 --> 02:03:24,680 EMPLOYEES, THERE'S A PLAN ISSUED 2889 02:03:24,680 --> 02:03:26,760 OUT IN SEPTEMBER SO EVERYONE IS 2890 02:03:26,760 --> 02:03:27,280 INVOLVED. 2891 02:03:27,280 --> 02:03:30,400 WE PLAN TO CELEBRATE IN WHAT I 2892 02:03:30,400 --> 02:03:32,480 CONSIDER SCIENTIFIC FOCUS AND 2893 02:03:32,480 --> 02:03:38,480 FOCUS ON THE TRAINEES OF THE 2894 02:03:38,480 --> 02:03:39,480 FUTURE. 2895 02:03:39,480 --> 02:03:40,680 CELEBRATING WITH NIAID AND NHLBI 2896 02:03:40,680 --> 02:03:42,840 AND PLAN TO HAVE A JOINT 2897 02:03:42,840 --> 02:03:45,480 SYMPOSIUM ON THE SCIENCE THAT 2898 02:03:45,480 --> 02:03:46,360 CONNECTS US. 2899 02:03:46,360 --> 02:03:48,400 HOWEVER, I THINK WHEN YOU ARE AT 2900 02:03:48,400 --> 02:03:51,280 THIS POINT AND THINKING ABOUT 2901 02:03:51,280 --> 02:03:53,040 THE CELEBRATION OF THE LEGACY 2902 02:03:53,040 --> 02:03:55,120 AND HISTORY, YOU HAVE TO BE 2903 02:03:55,120 --> 02:03:56,760 THINKING OF THE NEXT 25 YEARS. 2904 02:03:56,760 --> 02:03:59,640 AND YOU HAVE TO BE THINKING 2905 02:03:59,640 --> 02:04:02,880 WHERE SHOULD WE BE 25 YEARS FROM 2906 02:04:02,880 --> 02:04:06,640 NOW AS OUR VISION IS EXACTLY THE 2907 02:04:06,640 --> 02:04:09,720 SAME AS THE REASON HEAR TRUMAN 2908 02:04:09,720 --> 02:04:12,360 SIGNED US INTO EXISTENCE 74 2909 02:04:12,360 --> 02:04:13,960 YEARS AGO -- HARRY TRUMAN. 2910 02:04:13,960 --> 02:04:15,680 BE PART OF THIS PROCESS. 2911 02:04:15,680 --> 02:04:19,000 BE THE VISIONARY YOU ARE AND 2912 02:04:19,000 --> 02:04:25,240 SEND US IDEAS AND STAY ENGAGED. 2913 02:04:25,240 --> 02:04:26,360 WE DID CROSS THE 500 MILLION 2914 02:04:26,360 --> 02:04:31,360 MARK, IT'S A GOOD SIGN FOR WHAT 2915 02:04:31,360 --> 02:04:34,240 COMES NEXT. 2916 02:04:34,240 --> 02:04:39,560 WE'RE GRATEFUL FOR THE EXTRA $16 2917 02:04:39,560 --> 02:04:41,680 MILLION PLUS THAT WE'LL STEWARD. 2918 02:04:41,680 --> 02:04:47,440 THERE'S SO MUCH WORK BEHIND THE 2919 02:04:47,440 --> 02:04:50,520 SCENES, TO MAKE SURE WE KEEP THE 2920 02:04:50,520 --> 02:04:51,960 BALANCE BETWEEN NEW GRANTS AND 2921 02:04:51,960 --> 02:04:57,440 RENEWALS, WE LOOK AT THOSE WHO 2922 02:04:57,440 --> 02:04:59,680 HAVE ENDURED HARDSHIP IN COVID, 2923 02:04:59,680 --> 02:05:00,360 CREATING BALANCE BETWEEN 2924 02:05:00,360 --> 02:05:02,240 TRAINING AND CAREER DEVELOPMENT 2925 02:05:02,240 --> 02:05:03,360 SO WE'RE BEING RESPONSIBLE 2926 02:05:03,360 --> 02:05:05,640 STEWARDS OF THE PIPELINE FOR THE 2927 02:05:05,640 --> 02:05:06,000 FUTURE. 2928 02:05:06,000 --> 02:05:07,480 WE SHOULD EXPECT THAT PIECE OF 2929 02:05:07,480 --> 02:05:09,440 THE PIE TO INCREASE BUT IT IS 2930 02:05:09,440 --> 02:05:15,160 GOING TO BE AT THE EXPENSE OF 2931 02:05:15,160 --> 02:05:16,120 THE RPGs. 2932 02:05:16,120 --> 02:05:18,440 WE ARE KEEN ON CREATING THE 2933 02:05:18,440 --> 02:05:20,840 BALANCE OF EARLY-STAGE 2934 02:05:20,840 --> 02:05:27,800 INVESTIGATORS, IT'S A COMMITMENT 2935 02:05:27,800 --> 02:05:30,840 NIH-WIDE, TARGET OF 1100 EARLY 2936 02:05:30,840 --> 02:05:34,640 STAGE INVESTIGATORS FUNDED EVERY 2937 02:05:34,640 --> 02:05:35,000 YEAR. 2938 02:05:35,000 --> 02:05:37,880 WE MAKE SURE OR PORTFOLIO IS 2939 02:05:37,880 --> 02:05:40,680 BALANCED IN TERMS OF RESEARCH 2940 02:05:40,680 --> 02:05:44,720 INTEREST, WHO ARE GRANTEES, 2941 02:05:44,720 --> 02:05:46,000 RACE, ETHNIC, GENDER, 2942 02:05:46,000 --> 02:05:47,080 PROJECT-WISE, DISABILITY-WISE, 2943 02:05:47,080 --> 02:05:48,960 EVERYTHING IS BROUGHT INTO PLAY 2944 02:05:48,960 --> 02:05:52,160 AS WE LOOK AT OUR GRANTEE TALK. 2945 02:05:52,160 --> 02:05:53,480 I WANT YOU TO NOTE THAT. 2946 02:05:53,480 --> 02:05:55,760 THIS IS THE BALANCE AS IT EXISTS 2947 02:05:55,760 --> 02:05:59,680 TODAY AS WE KEEP A HEALTHY 2948 02:05:59,680 --> 02:06:06,400 PAYLINE, WORKING HARD TO 2949 02:06:06,400 --> 02:06:07,840 MAINTAIN THAT THROUGH FISCAL 2950 02:06:07,840 --> 02:06:08,080 YEAR 2023. 2951 02:06:08,080 --> 02:06:10,000 I WANT TO SHARE A TALK I'M 2952 02:06:10,000 --> 02:06:12,840 GIVING TOMORROW, IT'S A UNIQUE 2953 02:06:12,840 --> 02:06:13,640 OPPORTUNITY TO BE GRANTED 30 2954 02:06:13,640 --> 02:06:18,040 MINUTES WHERE I TALK TO FELLOW 2955 02:06:18,040 --> 02:06:18,960 AND STUDENT CENTER DIRECTORS. 2956 02:06:18,960 --> 02:06:21,160 I ASKED LARRY FOR THIS TIME. 2957 02:06:21,160 --> 02:06:24,800 THE FOCUS WAS TO HIGHLIGHT CALLS 2958 02:06:24,800 --> 02:06:26,320 TO ACTION BASED ON WHAT THE 2959 02:06:26,320 --> 02:06:27,920 REPORT INDICATED. 2960 02:06:27,920 --> 02:06:33,880 THERE'S ALSO I THINK A PLATFORM 2961 02:06:33,880 --> 02:06:36,520 BY WHICH I CAN ANNOUNCE WHO WE 2962 02:06:36,520 --> 02:06:37,840 ARE, IMPORTANT FOR US TO BE AT 2963 02:06:37,840 --> 02:06:40,080 THE TABLE FOR THE LARGE 2964 02:06:40,080 --> 02:06:42,640 INITIATIVE AND BE CONTRIBUTING 2965 02:06:42,640 --> 02:06:44,280 TO HEALTH PROGRESS OF HEALTH IN 2966 02:06:44,280 --> 02:06:44,520 GENERAL. 2967 02:06:44,520 --> 02:06:46,280 SO I THOUGHT I WOULD SIMPLY 2968 02:06:46,280 --> 02:06:49,920 SHARE WITH YOU, IT'S A DRY RUN 2969 02:06:49,920 --> 02:06:51,800 IN A WAY WHAT I WILL BE 2970 02:06:51,800 --> 02:06:52,680 PRESENTING TOMORROW. 2971 02:06:52,680 --> 02:06:58,360 WE IN THE PROFESSION NO MATTER 2972 02:06:58,360 --> 02:07:03,160 WHAT WE DO AMAZING PARADIGMS FOR 2973 02:07:03,160 --> 02:07:07,000 ORGANOGENESIS, SKULL, FACE, 2974 02:07:07,000 --> 02:07:08,560 TEETH, ET CETERA, PALATE, 2975 02:07:08,560 --> 02:07:09,760 MEASURES OF HOW GENES COORDINATE 2976 02:07:09,760 --> 02:07:11,640 ACTIVITY TO CREATE THIS 2977 02:07:11,640 --> 02:07:12,400 BEAUTIFUL FORM THAT IDENTIFIES 2978 02:07:12,400 --> 02:07:17,200 EACH ONE OF US AS UNIQUE HUMAN 2979 02:07:17,200 --> 02:07:18,880 BEINGS. 2980 02:07:18,880 --> 02:07:21,600 WE HAVE TONGUE, TASTE BUDS, YOU 2981 02:07:21,600 --> 02:07:24,000 KNOW THE SYSTEMS, TO ME OFFER 2982 02:07:24,000 --> 02:07:27,840 PARADIGMS FOR THE REST OF 2983 02:07:27,840 --> 02:07:28,920 BIOLOGY, MAMMALIAN. 2984 02:07:28,920 --> 02:07:30,840 BEYOND THAT COMES IMPORTANCE OF 2985 02:07:30,840 --> 02:07:32,320 THE ORAL CAVITY AS AF PORT O 2986 02:07:32,320 --> 02:07:35,480 ENTRY TO COMMON RISK FACTORS 2987 02:07:35,480 --> 02:07:40,840 THAT PREDISPOSE TO THREATEN 2988 02:07:40,840 --> 02:07:42,120 SYSTEMIC DISEASES, 2989 02:07:42,120 --> 02:07:43,480 CARDIOVASCULAR, METABOLIC 2990 02:07:43,480 --> 02:07:44,040 SYNDROME, DIABETES. 2991 02:07:44,040 --> 02:07:46,320 IT'S THROUGH THE ORAL CAVITY 2992 02:07:46,320 --> 02:07:48,080 THAT NUTRITION PASSES THROUGH, 2993 02:07:48,080 --> 02:07:50,840 E-CIGARETTES AND TOBACCO AND 2994 02:07:50,840 --> 02:07:53,040 ALCOHOL HAVE RUN THEIR TOLL ON 2995 02:07:53,040 --> 02:07:54,680 MUCOSA AND TISSUES AND OF COURSE 2996 02:07:54,680 --> 02:07:58,040 DRUGS AND ADDICTION. 2997 02:07:58,040 --> 02:07:59,760 WE CAN VIEW ORAL CAVITY 2998 02:07:59,760 --> 02:08:01,120 MANIFESTING SYSTEMIC DISEASE, WE 2999 02:08:01,120 --> 02:08:03,520 CAN MONITOR COMPLIANCE AND 3000 02:08:03,520 --> 02:08:06,480 HEALING AND TREATMENT PROTOCOLS, 3001 02:08:06,480 --> 02:08:07,880 ABSOLUTELY SO. 3002 02:08:07,880 --> 02:08:09,960 AND THAT DETERMINANTS OF HEALTH, 3003 02:08:09,960 --> 02:08:11,520 THERE'S NO OTHER SYSTEM WHERE WE 3004 02:08:11,520 --> 02:08:13,960 CAN SEE THEM AND OF AFFECT THE 3005 02:08:13,960 --> 02:08:15,520 STATUS OF ORAL HEALTH. 3006 02:08:15,520 --> 02:08:21,120 I'LL SHOW YOU OF THAT TO YOU. 3007 02:08:21,120 --> 02:08:25,840 WE HAVE TO BE PROUD TO BE AT THE 3008 02:08:25,840 --> 02:08:27,120 ABLE. 3009 02:08:27,120 --> 02:08:30,840 ORAL HEALTH WAS EMPHASIZED, 3010 02:08:30,840 --> 02:08:32,280 CONNECTIONS WERE BROUGHT TO THE 3011 02:08:32,280 --> 02:08:37,320 ATTENTION OF OUR NATION OVER 20 3012 02:08:37,320 --> 02:08:47,800 YEARS AGO BY SURGEON GENERAL 3013 02:08:51,600 --> 02:08:55,160 SATCHER. 3014 02:08:55,160 --> 02:08:57,280 FOCUSING ON NEED TO REPLICATE 3015 02:08:57,280 --> 02:08:59,120 AND BUILD SCIENCE BASE, INCREASE 3016 02:08:59,120 --> 02:09:00,760 DIVERSITY AS WE INCREASE 3017 02:09:00,760 --> 02:09:02,080 PARTNERSHIPS WITH OTHER 3018 02:09:02,080 --> 02:09:03,160 ORGANIZATIONS AND SCIENTIFIC 3019 02:09:03,160 --> 02:09:03,680 ENTITIES. 3020 02:09:03,680 --> 02:09:05,920 AND SO THE QUESTION I ASKED EACH 3021 02:09:05,920 --> 02:09:07,960 OF YOU TO REFLECT, BECAUSE SOME 3022 02:09:07,960 --> 02:09:10,520 OF HAVE BEEN AROUND FOR THESE 20 3023 02:09:10,520 --> 02:09:11,800 YEARS, WHAT PROGRESS WE'VE MADE 3024 02:09:11,800 --> 02:09:16,080 IN EACH OF THESE FRONTS. 3025 02:09:16,080 --> 02:09:17,200 WHILE THIS IS DEVELOPING OVER 3026 02:09:17,200 --> 02:09:18,800 THE LAST 20 YEARS, THE TRENDS 3027 02:09:18,800 --> 02:09:21,400 AND ATTENTION TO ORAL HEALTH AND 3028 02:09:21,400 --> 02:09:22,600 ITS CONNECTION WORLD HEALTH 3029 02:09:22,600 --> 02:09:24,840 ORGANIZATION DID PUT IT ON THE 3030 02:09:24,840 --> 02:09:25,400 MAP. 3031 02:09:25,400 --> 02:09:27,440 THERE'S A RESOLUTION PASSED ORAL 3032 02:09:27,440 --> 02:09:29,840 HEALTH IS ESSENTIAL FOR OVERALL 3033 02:09:29,840 --> 02:09:31,080 HEALTH, THAT ORAL HEALTH CARE 3034 02:09:31,080 --> 02:09:33,280 SHOULD BE PART OF UNIVERSAL 3035 02:09:33,280 --> 02:09:34,480 HEALTH COVERAGE. 3036 02:09:34,480 --> 02:09:42,280 AND THAT IS TAKING ON ITS OWN 3037 02:09:42,280 --> 02:09:43,520 MOMENTUM, SELLING INFORMATION 3038 02:09:43,520 --> 02:09:47,160 AND LEADING EFFORTS ACROSS THE 3039 02:09:47,160 --> 02:09:49,640 GLOBE. 3040 02:09:49,640 --> 02:09:49,960 THANK YOU. 3041 02:09:49,960 --> 02:09:53,400 "THE LANCET" HAS PRIORITIZED 3042 02:09:53,400 --> 02:09:56,200 ORAL HEALTH, SO NICE WHEN 3043 02:09:56,200 --> 02:09:57,440 SOMEONE OUTSIDE OUR FIELD TAKES 3044 02:09:57,440 --> 02:09:59,920 THIS ON, CAME UP WITH A 2019 3045 02:09:59,920 --> 02:10:04,440 SERIES THAT AGAIN STRESSED THE 3046 02:10:04,440 --> 02:10:04,760 FOLLOWING. 3047 02:10:04,760 --> 02:10:08,480 NOW THEY HAVE AUTHORIZED A 3048 02:10:08,480 --> 02:10:10,520 COMMISSION RELEASED I THINK 3049 02:10:10,520 --> 02:10:11,960 PASSED 2020 MOST LIKELY NEXT 3050 02:10:11,960 --> 02:10:16,320 YEAR, AUTHORIZED IN 2020, 3051 02:10:16,320 --> 02:10:18,560 TARGETED FOR RELEASE IN 2022-23. 3052 02:10:18,560 --> 02:10:19,960 IT HIGHLIGHTS AGAIN THE 3053 02:10:19,960 --> 02:10:23,800 IMPORTANCE, SO WHAT HAPPENS FOR 3054 02:10:23,800 --> 02:10:26,240 US IN THE U.S. WAS THIS GIFT THE 3055 02:10:26,240 --> 02:10:27,760 CURRENT SURGEON GENERAL COULD 3056 02:10:27,760 --> 02:10:29,200 NOT TAKE ON AT THE TIME HE 3057 02:10:29,200 --> 02:10:31,920 ASSUMED THE OFFICE FOR MANY, 3058 02:10:31,920 --> 02:10:34,440 MANY NATIONAL CRISES CRITICAL 3059 02:10:34,440 --> 02:10:34,800 REASONS. 3060 02:10:34,800 --> 02:10:36,840 SO NIH SHEPHERDED THIS THROUGH 3061 02:10:36,840 --> 02:10:39,080 AND THIS REPORT ITSELF STANDS AS 3062 02:10:39,080 --> 02:10:43,000 A CONTRIBUTION TO "THE LANCET" 3063 02:10:43,000 --> 02:10:43,280 COMMISSION. 3064 02:10:43,280 --> 02:10:45,080 AND AGAIN I SAY THANK YOU TO 3065 02:10:45,080 --> 02:10:50,200 THOSE WHO LED THIS REPORT, WHO 3066 02:10:50,200 --> 02:10:52,280 WROTE SECTIONS, A WIDE GROUP OF 3067 02:10:52,280 --> 02:10:54,480 CONTRIBUTORS, TO OUR OFFICE OF 3068 02:10:54,480 --> 02:10:57,320 COMMUNICATION AND HEALTH 3069 02:10:57,320 --> 02:11:00,000 EDUCATION, THAT WAS LED BY J.D. 3070 02:11:00,000 --> 02:11:04,320 JESS VENTURA, GRATEFUL FOR 3071 02:11:04,320 --> 02:11:06,960 LEADERSHIP AND MANAGEMENT. 3072 02:11:06,960 --> 02:11:08,480 THE BURDEN UPON ON US, WHAT DO 3073 02:11:08,480 --> 02:11:16,120 WE DO WITH THAT DATA? 3074 02:11:16,120 --> 02:11:20,040 PERSPECTIVE ARTICLES IN "LANCET" 3075 02:11:20,040 --> 02:11:22,920 AND NEW ENGLAND JOURNAL OF 3076 02:11:22,920 --> 02:11:23,320 MEDICINE. 3077 02:11:23,320 --> 02:11:26,840 THE REPORT IS 700 PAGES LONG, AN 3078 02:11:26,840 --> 02:11:28,720 EXECUTIVE SUMMARY IS 25 PAGES 3079 02:11:28,720 --> 02:11:28,920 LONG. 3080 02:11:28,920 --> 02:11:31,000 WE DECIDED TO TARGET PIECES OF A 3081 02:11:31,000 --> 02:11:32,560 CROSS-CUTTING THEME ACROSS THE 3082 02:11:32,560 --> 02:11:36,960 REPORT BASED ON LIFESPAN ALONE, 3083 02:11:36,960 --> 02:11:41,040 TO DIFFERENT SEGMENTS OF OUR 3084 02:11:41,040 --> 02:11:44,240 ORAL HEALTH PROFESSION, 3085 02:11:44,240 --> 02:11:48,080 CLINICIANS, JADA HIGHLIGHTS 3086 02:11:48,080 --> 02:11:50,200 THEIR ROLE. 3087 02:11:50,200 --> 02:11:51,640 NEED TO REVISE CURRICULUM, CALL 3088 02:11:51,640 --> 02:11:52,800 FOR ACTION EXISTS, WE KNEW WHAT 3089 02:11:52,800 --> 02:11:57,160 WE DIDN'T HAVE DURING THE 3090 02:11:57,160 --> 02:11:58,960 PANDEMIC AND WHAT NEEDS TO 3091 02:11:58,960 --> 02:12:01,680 CHANGE, OF COURSE LED BY LORI, 3092 02:12:01,680 --> 02:12:03,560 THE JDR ARTICLE TALKS ABOUT THE 3093 02:12:03,560 --> 02:12:06,400 SCIENCE AND TECHNOLOGY AT OUR 3094 02:12:06,400 --> 02:12:07,160 FINGERTIPS THAT WASN'T ABLE 20 3095 02:12:07,160 --> 02:12:09,880 YEARS AGO TO MOVE THE NEEDLE 3096 02:12:09,880 --> 02:12:10,200 FORWARD. 3097 02:12:10,200 --> 02:12:13,960 THESE PUBLICATIONS ON THE RIGHT 3098 02:12:13,960 --> 02:12:15,880 WILL BE RELEASED 25th OF MAY, 3099 02:12:15,880 --> 02:12:17,240 NEXT WEEK. 3100 02:12:17,240 --> 02:12:21,200 YOU CAN SEE THE DISSEMINATION 3101 02:12:21,200 --> 02:12:22,480 HAS BEEN WIDE. 3102 02:12:22,480 --> 02:12:24,200 WE'VE HAD GOOD COVERAGE, MANY 3103 02:12:24,200 --> 02:12:25,080 ORGANIZATIONS STEPPING UP TO 3104 02:12:25,080 --> 02:12:27,360 TAKE OWNERSHIP OF THE REPORT 3105 02:12:27,360 --> 02:12:28,280 BECAUSE THAT'S WHAT NIDCR WANTS 3106 02:12:28,280 --> 02:12:31,880 SO WE CAN HE CAN TO US ON THE 3107 02:12:31,880 --> 02:12:33,840 SCIENCE NEEDED TO MOVE FUNDS 3108 02:12:33,840 --> 02:12:34,080 FORWARD. 3109 02:12:34,080 --> 02:12:35,680 THIS TO ME WAS WHAT I THINK WAS 3110 02:12:35,680 --> 02:12:37,320 THE KEY MESSAGE FROM THE REPORT 3111 02:12:37,320 --> 02:12:40,800 THAT PEOPLE IN THE U.S. 3112 02:12:40,800 --> 02:12:42,160 POPULATION, SELECT POPULATION, 3113 02:12:42,160 --> 02:12:42,920 DISADVANTAGED. 3114 02:12:42,920 --> 02:12:43,840 THEY ARE. 3115 02:12:43,840 --> 02:12:44,800 EXPERIENCE ORAL HEALTH 3116 02:12:44,800 --> 02:12:45,080 DIFFERENTLY. 3117 02:12:45,080 --> 02:12:47,560 AND WE HAVE TO ASK THE QUESTION 3118 02:12:47,560 --> 02:12:52,320 AS TO WHY IN 20 YEARS THAT 3119 02:12:52,320 --> 02:12:53,880 HASN'T CHANGED. 3120 02:12:53,880 --> 02:12:56,200 WE NEED TO CONVERT WHAT WE DO 3121 02:12:56,200 --> 02:12:58,160 INTO WHAT WE -- WHAT WE KNOW 3122 02:12:58,160 --> 02:12:59,120 INTO WHAT WE ACTUALLY DO. 3123 02:12:59,120 --> 02:13:01,760 IF YOU LOOK IT THE LEFT COLUMN 3124 02:13:01,760 --> 02:13:03,960 THESE ARE THINGS UNDOUBTEDLY 3125 02:13:03,960 --> 02:13:06,160 HAVE TRANSFORMED THE PAST TWO 3126 02:13:06,160 --> 02:13:06,800 DECADES, DEMOGRAPHICS HAVE 3127 02:13:06,800 --> 02:13:09,400 CHANGED, WE MOVED INTO A VERY 3128 02:13:09,400 --> 02:13:12,200 POWERFUL DIGITAL ERA AND HENCE 3129 02:13:12,200 --> 02:13:14,680 DATA SCIENCE OPPORTUNITY EXISTS. 3130 02:13:14,680 --> 02:13:17,120 DELIVERY OF SERVICES, 3131 02:13:17,120 --> 02:13:20,040 DELIVERABLES, DIAGNOSTICS HAVE 3132 02:13:20,040 --> 02:13:21,560 ALL RADICALLY CHANGED. 3133 02:13:21,560 --> 02:13:32,120 DISEASE TRENDS EVOLVING, WE HAVE 3134 02:13:35,600 --> 02:13:39,600 HIV, OROPHARYNGEAL CANCERS, BUT 3135 02:13:39,600 --> 02:13:41,040 WE HAVE BARRIERS, THE PANDEMIC 3136 02:13:41,040 --> 02:13:43,560 BROUGHT THEM TO LIGHT, THAT 3137 02:13:43,560 --> 02:13:45,080 PREVENTS US FROM DELIVERING 3138 02:13:45,080 --> 02:13:49,440 SOMETHING THAT WOULD BENEFIT 3139 02:13:49,440 --> 02:13:51,840 ALL. 3140 02:13:51,840 --> 02:13:53,760 THOSE ARE THE ACTUAL STATISTICS. 3141 02:13:53,760 --> 02:13:58,560 MANY RANKING AS THE MOST COMMON 3142 02:13:58,560 --> 02:13:59,680 IN MANKIND. 3143 02:13:59,680 --> 02:14:04,600 THERE ARE OTHER BURDENS THAT 3144 02:14:04,600 --> 02:14:06,440 SOCIETY THAT AFFECT OUR SOCIETY 3145 02:14:06,440 --> 02:14:07,400 AND PUBLIC HEALTH. 3146 02:14:07,400 --> 02:14:10,360 THIS IS SEARCH NOT NEW STUFF. 3147 02:14:10,360 --> 02:14:12,960 IT'S THINGS THAT WE'VE SOMEHOW 3148 02:14:12,960 --> 02:14:14,560 HAVE TO INTEGRATE INTO THE 3149 02:14:14,560 --> 02:14:16,720 RESEARCH WE PERFORM AND TO 3150 02:14:16,720 --> 02:14:23,520 PROGRAMS WE HAVE RESPONSIBLY 3151 02:14:23,520 --> 02:14:24,040 FOR. 3152 02:14:24,040 --> 02:14:26,880 IT DOES INVOLVE POLICY REFORM, 3153 02:14:26,880 --> 02:14:28,440 EDUCATIONAL SYSTEMS, NIDCR CAN 3154 02:14:28,440 --> 02:14:29,880 DO THAT, WE CAN SUPPORT OR 3155 02:14:29,880 --> 02:14:35,280 CREATE EVIDENCE THAT CAN GUIDE 3156 02:14:35,280 --> 02:14:35,560 SUCH REFORM. 3157 02:14:35,560 --> 02:14:39,240 I WANT TO GIVE AN EXAMPLE OF A 3158 02:14:39,240 --> 02:14:40,720 DISEASE, THE REASON WE WERE 3159 02:14:40,720 --> 02:14:42,280 CREATED, YOUNG MEN COULD THE NO 3160 02:14:42,280 --> 02:14:46,640 BE RECRUITED TO WAR BECAUSE THEY 3161 02:14:46,640 --> 02:14:51,000 HAD MOUTHS DEVASTATED BY CARIES, 3162 02:14:51,000 --> 02:14:52,280 BEFORE FLUORIDE WAS INTRODUCED. 3163 02:14:52,280 --> 02:14:56,200 YOU CAN SEE WHEN A CHILD SETS 3164 02:14:56,200 --> 02:15:00,920 UP, THIS HAPPENING, NURSING 3165 02:15:00,920 --> 02:15:02,240 BOTTLE CARIES, IMPAIRMENT OF 3166 02:15:02,240 --> 02:15:04,400 FUNCTION, CHILDREN HAVE TO BE 3167 02:15:04,400 --> 02:15:05,720 TREATED UNDER ANESTHESIA AND 3168 02:15:05,720 --> 02:15:09,760 JUST THEN FACE A LIFETIME OF 3169 02:15:09,760 --> 02:15:11,960 DISEASE, IF NOT CORRECTED AND 3170 02:15:11,960 --> 02:15:12,240 MITIGATED. 3171 02:15:12,240 --> 02:15:14,560 WE ALSO HAVE VERY DISTURBING 3172 02:15:14,560 --> 02:15:15,680 TRENDS IN THE TRIBAL NATIONS 3173 02:15:15,680 --> 02:15:18,960 WHERE WE HAVE A VERY HIGH 3174 02:15:18,960 --> 02:15:20,840 PERCENTAGE OF DECAY, THREE TO 3175 02:15:20,840 --> 02:15:22,720 FIVE YEAR OLDS RAVAGED WITH 3176 02:15:22,720 --> 02:15:24,000 PAIN, IN THIS SCHOOL ADULTS 3177 02:15:24,000 --> 02:15:25,320 RUNNING TO THE E.R. SEEKING HELP 3178 02:15:25,320 --> 02:15:29,160 FROM THE E.R. MOST OFTEN 3179 02:15:29,160 --> 02:15:29,840 PALLIATIVE, OFTENTIMES 3180 02:15:29,840 --> 02:15:30,840 PRESCRIBED MEDICATION THAT THEY 3181 02:15:30,840 --> 02:15:32,440 SOMETIMES GET ADDICTED TO. 3182 02:15:32,440 --> 02:15:35,840 IT'S A VICIOUS CYCLE. 3183 02:15:35,840 --> 02:15:37,720 AND THIS EXAMPLE OF TRIBAL 3184 02:15:37,720 --> 02:15:43,560 NATIONS IS REFLECTED IN ALL OUR 3185 02:15:43,560 --> 02:15:44,600 DISADVANTAGED AND MINORITY 3186 02:15:44,600 --> 02:15:44,920 POPULATIONS. 3187 02:15:44,920 --> 02:15:46,720 THERE'S NEED TO PAY ATTENTION TO 3188 02:15:46,720 --> 02:15:47,920 INTERSECTION AREAS WITH 3189 02:15:47,920 --> 02:15:49,120 DIFFERENT LENSES, FROM WHAT WE 3190 02:15:49,120 --> 02:15:51,320 USED BEFORE. 3191 02:15:51,320 --> 02:15:54,280 THAT IN FACT DURING THE PANDEMIC 3192 02:15:54,280 --> 02:15:56,960 AS MY COLLEAGUE WHO DIRECTS THE 3193 02:15:56,960 --> 02:15:59,320 NATIONAL INSTITUTE OF DRUG ABUSE 3194 02:15:59,320 --> 02:16:01,840 WILL SAY ON MANY PLATFORMS THE 3195 02:16:01,840 --> 02:16:05,840 NUMBER OF SUBSTANCE USE 3196 02:16:05,840 --> 02:16:07,240 DISORDERS HAS RISEN ALMOST 3197 02:16:07,240 --> 02:16:09,120 FOUR-FOLD DURING THE PANDEMIC. 3198 02:16:09,120 --> 02:16:12,280 WE HAVE DRUGS LIKE OPIOIDS NOW 3199 02:16:12,280 --> 02:16:16,800 CONTAMINATED WITH FENTANYL, AND 3200 02:16:16,800 --> 02:16:20,240 METH, AND THAT IN FACT 3201 02:16:20,240 --> 02:16:21,920 OPIOID-RELATED SUICIDE ARE ON 3202 02:16:21,920 --> 02:16:22,680 THE INCREASE ESPECIALLY IN 3203 02:16:22,680 --> 02:16:22,920 TEENAGERS. 3204 02:16:22,920 --> 02:16:24,560 WE HAVE THE NEED TO CORRECT 3205 02:16:24,560 --> 02:16:26,200 MENTAL HEALTH AND ORAL HEALTH 3206 02:16:26,200 --> 02:16:28,280 WITH SUBSTANCE USE DISORDERS AND 3207 02:16:28,280 --> 02:16:30,680 THOSE INTERSECTION AREAS THAT WE 3208 02:16:30,680 --> 02:16:32,880 AS RESEARCHERS AND ORAL HEALTH 3209 02:16:32,880 --> 02:16:35,520 PROFESSIONALS CAN CONNECT DOTS 3210 02:16:35,520 --> 02:16:37,720 ACROSS THESE ECOSYSTEMS, IT'S 3211 02:16:37,720 --> 02:16:38,800 CRITICAL FOR OUR SOCIETY. 3212 02:16:38,800 --> 02:16:40,440 THIS IS ALSO NOT A NEW CONCEPT 3213 02:16:40,440 --> 02:16:43,600 FOR US TO BE THINKING IN THE WAY 3214 02:16:43,600 --> 02:16:46,360 WE APPROACH DISEASE, THAT WE'RE 3215 02:16:46,360 --> 02:16:51,480 NOT LOOKING AT ONE RESTORATION, 3216 02:16:51,480 --> 02:16:54,320 BUT WE LOOK AT THE SITUATION 3217 02:16:54,320 --> 02:16:56,400 THAT SURROUNDS THE PARTICULAR 3218 02:16:56,400 --> 02:16:57,600 PATIENT, THAT FAMILY INFLUENCES 3219 02:16:57,600 --> 02:16:59,360 WHAT IS IN THE REFRIGERATOR AT 3220 02:16:59,360 --> 02:17:04,320 HOME, WHAT KIDS ARE EATING IN 3221 02:17:04,320 --> 02:17:05,200 SCHOOL, COMMUNITY LEVEL 3222 02:17:05,200 --> 02:17:06,800 INFLUENCES PLAY INTO HOLISTIC 3223 02:17:06,800 --> 02:17:07,800 APPROACH ON HEALTH. 3224 02:17:07,800 --> 02:17:11,200 AND I LOVE THIS SLIDE BECAUSE IT 3225 02:17:11,200 --> 02:17:13,120 TELLS US THAT NIDCR CAN'T BE 3226 02:17:13,120 --> 02:17:15,600 JUST IN THAT RESEARCH SPECTRUM. 3227 02:17:15,600 --> 02:17:18,960 DOMINO EFFECT HERE, I COULD HAVE 3228 02:17:18,960 --> 02:17:20,840 FILLED UP EACH BOWL BALL. 3229 02:17:20,840 --> 02:17:22,240 WE HAVE TO PAY ATTENTION TO 3230 02:17:22,240 --> 02:17:26,760 WHAT'S HAPPENING IN THE PRIVATE 3231 02:17:26,760 --> 02:17:27,720 SECTOR AND EDUCATIONAL WORLD. 3232 02:17:27,720 --> 02:17:29,280 I ASKED LARRY THAT QUESTION, 3233 02:17:29,280 --> 02:17:34,040 EACH OF US ARE MUTUALLY 3234 02:17:34,040 --> 02:17:34,880 DEPENDENT. 3235 02:17:34,880 --> 02:17:36,240 ONE SIDE SUCCEEDS, BENEFITS THE 3236 02:17:36,240 --> 02:17:38,760 RESEARCH WORLD, RIGHT? 3237 02:17:38,760 --> 02:17:40,000 MUTUALLY REINFORCING TO PREPARE 3238 02:17:40,000 --> 02:17:41,520 AN ENTIRE SYSTEM. 3239 02:17:41,520 --> 02:17:45,800 THAT IS THE PRINCIPLE THAT WE 3240 02:17:45,800 --> 02:17:48,440 ARE OF OUR STAFF, P.I.s AT 3241 02:17:48,440 --> 02:17:52,040 NIH, JANICE LEE AND HER ENDEAVOR 3242 02:17:52,040 --> 02:17:54,000 WITH OFFICE OF CLINICAL RESEARCH 3243 02:17:54,000 --> 02:17:56,480 OFFICE AND BUILDING 10 IS 3244 02:17:56,480 --> 02:17:57,360 FOCUSED ON. 3245 02:17:57,360 --> 02:18:00,680 THAT DIVERSITY, EQUITY, AND 3246 02:18:00,680 --> 02:18:07,560 INCLUSION AND ACCESSIBILITY 3247 02:18:07,560 --> 02:18:09,000 REMAIN INTERTWINING THEMES. 3248 02:18:09,000 --> 02:18:12,960 THERE IS A BIAS ORAL HEALTH IS 3249 02:18:12,960 --> 02:18:16,200 NOT AS CRITICAL, WE ONLY THINK 3250 02:18:16,200 --> 02:18:19,120 OF TEETH AND WHITENING, PART OF 3251 02:18:19,120 --> 02:18:23,560 OUR PROFESSION THEMSELVES DO NOT 3252 02:18:23,560 --> 02:18:26,760 PRIORITIZE THE IMPORTANCE OF 3253 02:18:26,760 --> 02:18:28,800 RESEARCH AND KNOWLEDGE BASES. 3254 02:18:28,800 --> 02:18:32,240 WE HAVE PEER REVIEW SYSTEMS NOT 3255 02:18:32,240 --> 02:18:33,160 NECESSARILY AWARE OF OR 3256 02:18:33,160 --> 02:18:34,520 FAVORABLE FOR ADVANCEMENT OF 3257 02:18:34,520 --> 02:18:35,960 ORAL HEALTH SCIENCES. 3258 02:18:35,960 --> 02:18:37,120 IT'S A DIFFICULT ONE TO ADDRESS 3259 02:18:37,120 --> 02:18:41,600 BUT WHAT WE NEED TO MAKE SURE 3260 02:18:41,600 --> 02:18:47,200 HAPPENS IS CONSTANTLY FEED A 3261 02:18:47,200 --> 02:18:48,080 ROBUST PIPELINE OF REVIEWERS TO 3262 02:18:48,080 --> 02:18:50,360 LOOK AT GRANTS FROM THE ORAL 3263 02:18:50,360 --> 02:18:54,240 HEALTH SCIENCES. 3264 02:18:54,240 --> 02:18:56,720 THERE ARE ANECDOTAL REFERENCES, 3265 02:18:56,720 --> 02:18:59,040 AND SOMETIMES WITH BIRTH OF BEST 3266 02:18:59,040 --> 02:19:01,320 PRACTICES, AND THE REST YOU KNOW 3267 02:19:01,320 --> 02:19:01,800 ABOUT. 3268 02:19:01,800 --> 02:19:05,120 SO ONE OF THE SOLUTIONS TO HAVE 3269 02:19:05,120 --> 02:19:07,000 A STRATEGIC PLAN THAT 3270 02:19:07,000 --> 02:19:08,120 ENCOMPASSES THIS THINKING, AND 3271 02:19:08,120 --> 02:19:10,640 SO IN A DISEASE AGNOSTIC WAY WE 3272 02:19:10,640 --> 02:19:11,520 DECIDED THAT THE OVERALL 3273 02:19:11,520 --> 02:19:13,960 EMPHASIS SHOULD BE ON 3274 02:19:13,960 --> 02:19:14,240 TRANSLATION. 3275 02:19:14,240 --> 02:19:16,320 AND I KNOW LARRY STRESSED THAT 3276 02:19:16,320 --> 02:19:20,240 IN DIFFERENT WAYS, THAT WE HAVE 3277 02:19:20,240 --> 02:19:22,920 TO MATCH THE NEEDS OF 3278 02:19:22,920 --> 02:19:23,800 POPULATIONS, DEMOGRAPHICS 3279 02:19:23,800 --> 02:19:26,840 SLOWSLY IN SYNC, LOOK AT WHAT 3280 02:19:26,840 --> 02:19:27,840 WE'RE DOING WELL. 3281 02:19:27,840 --> 02:19:29,720 AND REPEAT THOSE BEST PRACTICES 3282 02:19:29,720 --> 02:19:31,040 AND LOOK AT PROGRAMS THROUGH 3283 02:19:31,040 --> 02:19:33,080 WHICH THE RETURN OF INVESTMENT 3284 02:19:33,080 --> 02:19:34,560 IS NOT THAT ROBUST. 3285 02:19:34,560 --> 02:19:38,240 IN FACT WE JUST HAVE ONE PIE WE 3286 02:19:38,240 --> 02:19:39,520 NEED TO BALANCE OUT VERY 3287 02:19:39,520 --> 02:19:41,920 RESPONSIBLY FOR THE FUTURE. 3288 02:19:41,920 --> 02:19:43,320 WE HAVE STRICT CORE VALUES THAT 3289 02:19:43,320 --> 02:19:45,120 GUIDE OUR THINKING. 3290 02:19:45,120 --> 02:19:46,960 SO JUST TO REFRESH, AGAIN ON THE 3291 02:19:46,960 --> 02:19:49,360 LEFT IT PUTS THE PATIENT IN THE 3292 02:19:49,360 --> 02:19:50,880 CENTER, EMPHASIZES THAT ALL 3293 02:19:50,880 --> 02:19:53,960 ASPECTS OF RESEARCH IS 3294 02:19:53,960 --> 02:19:54,640 IMPORTANT. 3295 02:19:54,640 --> 02:19:56,040 THAT THE TRANSLATIONAL SPECTRUM 3296 02:19:56,040 --> 02:19:59,240 HAS THE PATIENT IN FIND OF MIND 3297 02:19:59,240 --> 02:20:01,520 SO USE-DRIVEN RESEARCH DOESN'T 3298 02:20:01,520 --> 02:20:02,880 TAKE OVER CURIOSITY-DRIVEN. 3299 02:20:02,880 --> 02:20:04,040 WE SHOULD NEVER THINK THAT WAY 3300 02:20:04,040 --> 02:20:06,080 BUT IN A WAY THINKING ALL THE 3301 02:20:06,080 --> 02:20:08,200 TIME ABOUT RELEVANCE TO WHAT THE 3302 02:20:08,200 --> 02:20:11,040 APPLICATION MIGHT BE, EVEN IF IT 3303 02:20:11,040 --> 02:20:11,360 IS DOWNSTREAM. 3304 02:20:11,360 --> 02:20:14,240 AND WE LOOK AT THE SYSTEMIC ORAL 3305 02:20:14,240 --> 02:20:15,560 HEALTH CONSEQUENCES NOW WITH A 3306 02:20:15,560 --> 02:20:17,120 REAL SENSE OF WHAT IS THE 3307 02:20:17,120 --> 02:20:22,560 UNDERLYING CONNECTION, WHAT ARE 3308 02:20:22,560 --> 02:20:23,960 THE MECHANISMS, HOW DO WE 3309 02:20:23,960 --> 02:20:26,200 PERSONALIZE AND CONSIDER THE 3310 02:20:26,200 --> 02:20:28,400 UNIQUE MAKEUP OF INDIVIDUALS, 3311 02:20:28,400 --> 02:20:31,880 HOW DO WE TRANSLATE TO CHAIRSIDE 3312 02:20:31,880 --> 02:20:32,840 AND COMMUNITIES, IMPLEMENTATION 3313 02:20:32,840 --> 02:20:35,720 SCIENCES THAT WE HAVE A ROBUST 3314 02:20:35,720 --> 02:20:39,480 BUT ROOM TO GROW IN THAT AREA AS 3315 02:20:39,480 --> 02:20:40,920 WE DIVERSIFY OUR NEW GENERATION 3316 02:20:40,920 --> 02:20:41,880 AND EXPAND OUR PARTNERSHIPS. 3317 02:20:41,880 --> 02:20:44,560 YOU SEE THEY ARE TAKING THAT 3318 02:20:44,560 --> 02:20:45,920 SERIOUSLY. 3319 02:20:45,920 --> 02:20:48,760 WE HAVE THESE STATISTICS NOTHING 3320 02:20:48,760 --> 02:20:54,240 THAT SHOULD ALARM YOU. 3321 02:20:54,240 --> 02:20:56,640 NIDCR HAS PORTFOLIO GRANTEES, IT 3322 02:20:56,640 --> 02:20:58,280 LOOKS PRETTY DISCOURAGING BUT WE 3323 02:20:58,280 --> 02:21:00,080 HAVE A PLAN OF ACTION TO REALLY, 3324 02:21:00,080 --> 02:21:01,600 REALLY MAKE A DIFFERENCE. 3325 02:21:01,600 --> 02:21:04,000 YOU CAN SEE FROM THE WORKFORCE 3326 02:21:04,000 --> 02:21:06,720 ITSELF OF INDIVIDUALS OUT IN THE 3327 02:21:06,720 --> 02:21:08,680 PRACTICING SECTOR THAT WE ARE 3328 02:21:08,680 --> 02:21:13,280 NOT ACCESSING ALL THE 3329 02:21:13,280 --> 02:21:14,680 POPULATIONS IN NEED. 3330 02:21:14,680 --> 02:21:16,880 LARRY MENTIONED UNITE. 3331 02:21:16,880 --> 02:21:20,320 FROM THERE CAME THE UMBRELLA 3332 02:21:20,320 --> 02:21:21,280 PROGRAM THAT OVERARCHING THEME. 3333 02:21:21,280 --> 02:21:26,200 I REMEMBER IN ONE OF MY FIRST 3334 02:21:26,200 --> 02:21:27,520 COUNCIL MEETINGS MENTIONING THE 3335 02:21:27,520 --> 02:21:30,520 PUBLIC/PRIVATE PARTNERSHIP. 3336 02:21:30,520 --> 02:21:31,560 WE THOUGHT DIFFERENT CONVERGING 3337 02:21:31,560 --> 02:21:34,720 FRONTS THAT WE CANNOT DO IT BY 3338 02:21:34,720 --> 02:21:36,280 FOCUSING ON THE BIOMEDICAL 3339 02:21:36,280 --> 02:21:37,480 RESEARCH PIPELINE DEVELOPMENT 3340 02:21:37,480 --> 02:21:38,400 ITSELF. 3341 02:21:38,400 --> 02:21:44,040 WE HAVE TO PARTNER WITH 3342 02:21:44,040 --> 02:21:47,840 ORGANIZATIONS LIKE ADA, NDA, 3343 02:21:47,840 --> 02:21:50,160 ADEA, DEANS, WHO MADE A 3344 02:21:50,160 --> 02:21:51,160 DIFFERENCE, THOUGHT LEADERS, ET 3345 02:21:51,160 --> 02:21:54,200 CETERA, PLUS INDUSTRY PARTNERS. 3346 02:21:54,200 --> 02:21:55,640 AND JENNIFER WEBSTER CYRIAQUE IS 3347 02:21:55,640 --> 02:21:58,480 COMMITTED TO THIS EFFORT. 3348 02:21:58,480 --> 02:21:59,880 IT'S NOT AN EASY ONE, DRAWING 3349 02:21:59,880 --> 02:22:01,760 THE TEAM TOGETHER SO WE HAVE A 3350 02:22:01,760 --> 02:22:06,880 ROAD MAP AND CAN MOVE FORWARD. 3351 02:22:06,880 --> 02:22:08,960 I WANT TO SAY JENNIFER WAS 3352 02:22:08,960 --> 02:22:12,400 REALLY BEHIND A LOT OF THE 3353 02:22:12,400 --> 02:22:15,240 "HEAL" INTERACTIONS WE'VE HAD 3354 02:22:15,240 --> 02:22:16,320 WITH "HEAL," LARRY MENTIONED ME 3355 02:22:16,320 --> 02:22:18,280 BUT JENNIFER IS THE ONE WHO SITS 3356 02:22:18,280 --> 02:22:19,480 THROUGH THE MEETINGS AND HAS 3357 02:22:19,480 --> 02:22:20,680 MADE A REAL DIFFERENCE PUTTING 3358 02:22:20,680 --> 02:22:22,880 ORAL HEALTH IN THE FOREFRONT OF 3359 02:22:22,880 --> 02:22:25,520 THINKING WITH "HEAL." 3360 02:22:25,520 --> 02:22:30,040 AND PAIN MANAGEMENT. 3361 02:22:30,040 --> 02:22:31,880 WE HAVE TWO AMAZING PROGRAMS, WE 3362 02:22:31,880 --> 02:22:33,160 TRAIN FELLOWS. 3363 02:22:33,160 --> 02:22:34,800 HERE IS THE CLINICAL RESEARCH 3364 02:22:34,800 --> 02:22:37,120 FELLOWSHIP DEVELOPED FROM THE 3365 02:22:37,120 --> 02:22:40,760 WORK JIM MELVIN DID ON THE 3366 02:22:40,760 --> 02:22:42,520 FOUNDATIONS, DEVELOPED INTO A 3367 02:22:42,520 --> 02:22:45,120 NATIONALLY RECOGNIZED PROGRAM. 3368 02:22:45,120 --> 02:22:48,200 THESE SCHOLARS FIND VERY, VERY 3369 02:22:48,200 --> 02:22:49,840 GOOD FACULTY POSITIONS AND 3370 02:22:49,840 --> 02:22:52,480 REALLY FORGING PATHS IN CLINICAL 3371 02:22:52,480 --> 02:22:53,560 RESEARCH METHODOLOGY AND 3372 02:22:53,560 --> 02:22:55,280 TREATMENT FOR PATIENTS IN A 3373 02:22:55,280 --> 02:22:57,080 VARIETY OF CONDITIONS AND MANY 3374 02:22:57,080 --> 02:22:58,480 INSTITUTIONS AROUND THE COUNTRY. 3375 02:22:58,480 --> 02:23:03,840 THIS IS THE DEADLINE FOR THIS, 3376 02:23:03,840 --> 02:23:06,240 TYPICALLY TAKING SIX FELLOWS A 3377 02:23:06,240 --> 02:23:08,200 YEAR, SIX GENERAL, I THINK THEY 3378 02:23:08,200 --> 02:23:09,400 TAKE TWO TO THREE A YEAR, AND 3379 02:23:09,400 --> 02:23:17,120 YOU HAVE TO OBVIOUSLY HAVE A DDS 3380 02:23:17,120 --> 02:23:22,960 OR DDS Ph.D. 3381 02:23:22,960 --> 02:23:26,480 WE'VE REINSTATED THE FELLOWS 3382 02:23:26,480 --> 02:23:28,600 PROGRAM, WE'VE ADDED SOMETHING 3383 02:23:28,600 --> 02:23:30,400 UNIQUE, TO HAVE THESE TRAINEES 3384 02:23:30,400 --> 02:23:35,320 GET THROUGH THE DENTAL PUBLIC 3385 02:23:35,320 --> 02:23:36,560 HEALTH CERTIFICATION AND 3386 02:23:36,560 --> 02:23:37,640 CURRICULUM AS PRESCRIBED AND GET 3387 02:23:37,640 --> 02:23:41,080 INTO TWO YEARS OF FOCUSED 3388 02:23:41,080 --> 02:23:45,400 RESEARCH EXPERIENCE IN A LAB 3389 02:23:45,400 --> 02:23:47,600 EPIDEMIOLOGY AT NCI, EXAMPLE, 3390 02:23:47,600 --> 02:23:50,440 NIA, NATIONAL INSTITUTE OF 3391 02:23:50,440 --> 02:23:52,480 AGING, INTERESTING ON 3392 02:23:52,480 --> 02:23:54,040 CORRELATION WITH COGNITIVE 3393 02:23:54,040 --> 02:23:54,400 DECLINE. 3394 02:23:54,400 --> 02:23:58,360 I HOPE THAT IT PROVIDES US WITH 3395 02:23:58,360 --> 02:24:00,280 KNOWLEDGE CREATORS FOR THIS 3396 02:24:00,280 --> 02:24:02,080 FIELD, THAT WOULD THEN GO OUT 3397 02:24:02,080 --> 02:24:03,720 INTO THE COUNTRY AND BE THOUGHT 3398 02:24:03,720 --> 02:24:06,320 LEADERS AS WELL AS IT CAN BE 3399 02:24:06,320 --> 02:24:10,520 MODEL FOR OTHER PROGRAMS TO 3400 02:24:10,520 --> 02:24:13,040 FOLLOW IF POSSIBLE IN CAMPUSES 3401 02:24:13,040 --> 02:24:13,880 AROUND THE COUNTRY. 3402 02:24:13,880 --> 02:24:17,720 VERY PLEASED AGAIN TO HAVE A 3403 02:24:17,720 --> 02:24:20,880 VERY STRONG TEAM, BELINDA HOUSER 3404 02:24:20,880 --> 02:24:23,960 WHO WORKS WITH MATT HOFFMAN IN 3405 02:24:23,960 --> 02:24:27,120 INTRAMURAL HAS BEEN ACTIVE IN 3406 02:24:27,120 --> 02:24:28,440 GUIDING INTRAMURAL RESEARCH 3407 02:24:28,440 --> 02:24:30,320 EXPERIENCES FOR SCHOLARS, SHE'S 3408 02:24:30,320 --> 02:24:31,120 VERY WELL CONNECTED WITH 3409 02:24:31,120 --> 02:24:32,480 UNIVERSITY OF MARYLAND AND 3410 02:24:32,480 --> 02:24:35,440 HOWARD AND HAS GOT PIPELINE 3411 02:24:35,440 --> 02:24:40,280 PROGRAMS COMING IN, SUMMER OR 3412 02:24:40,280 --> 02:24:41,120 LONGER PROGRAMS THAT SOMETIMES 3413 02:24:41,120 --> 02:24:43,560 LAST A YEAR OR TWO. 3414 02:24:43,560 --> 02:24:46,960 LYNN KING HAS MOVED UP, TO BE 3415 02:24:46,960 --> 02:24:49,000 DIRECTOR, TO TAKE HER POSITION 3416 02:24:49,000 --> 02:24:53,960 IS ANISSA BROWN WHO I INTRODUCED 3417 02:24:53,960 --> 02:24:55,400 EARLIER ON. 3418 02:24:55,400 --> 02:24:57,200 AND THANKS TO LESLIE FRIEDEN, 3419 02:24:57,200 --> 02:24:58,320 WHO YOU APPRECIATE BECAUSE 3420 02:24:58,320 --> 02:25:01,280 LESLIE PUTS HER HEART AND SOUL 3421 02:25:01,280 --> 02:25:02,000 INTO INDIVIDUAL MENTORING AND 3422 02:25:02,000 --> 02:25:04,480 SUPPORT FOR ALL OF ON TRAINEES. 3423 02:25:04,480 --> 02:25:05,680 HOW ARE WE DOING? 3424 02:25:05,680 --> 02:25:07,840 YOU CAN SEE IN THE PINK BOXES 3425 02:25:07,840 --> 02:25:15,400 THE PROGRAMS THAT INTRAMURAL 3426 02:25:15,400 --> 02:25:16,240 OFFERS. 3427 02:25:16,240 --> 02:25:18,360 WE HAVE OTHER MEANS BY WHICH AN 3428 02:25:18,360 --> 02:25:27,200 INTRAMURAL TRAINEE CAN SEEK A 3429 02:25:27,200 --> 02:25:27,800 PERMANENT POSITION, EVERYTHING 3430 02:25:27,800 --> 02:25:29,960 IS BLUE WE OFFER TO THE 3431 02:25:29,960 --> 02:25:31,040 EXTRAMURAL COMMUNITY. 3432 02:25:31,040 --> 02:25:32,000 MANY KNOW WE'VE PAID A LOT OF 3433 02:25:32,000 --> 02:25:33,640 ATTENTION TO LEAKS IN THE 3434 02:25:33,640 --> 02:25:37,200 PIPELINE AND HAVE BRIDGE GRANTS 3435 02:25:37,200 --> 02:25:39,240 TO ASSIST PRE-DOCTORAL, DOCTORAL 3436 02:25:39,240 --> 02:25:40,240 TRANSITION, POSTDOCTORAL TO 3437 02:25:40,240 --> 02:25:41,440 FACULTY TRANSITION. 3438 02:25:41,440 --> 02:25:42,760 NOW, WHAT IS ACTUALLY 3439 02:25:42,760 --> 02:25:43,880 DRAMATICALLY INCREASED OVER THE 3440 02:25:43,880 --> 02:25:46,880 LAST YEAR AS WE LOOKED AT THESE 3441 02:25:46,880 --> 02:25:49,320 MECHANISMS, THE AMOUNT OF 3442 02:25:49,320 --> 02:25:50,960 OPPORTUNITY AVAILABLE FOR 3443 02:25:50,960 --> 02:25:52,320 DIVERSITY, EQUITY DEVELOPMENT. 3444 02:25:52,320 --> 02:25:57,680 YOU CAN SEE THESE ARE NOT OUR 3445 02:25:57,680 --> 02:25:58,520 PROGRAMS. 3446 02:25:58,520 --> 02:25:59,520 WE HAVE DOVETAILED, LATCHED MANY 3447 02:25:59,520 --> 02:26:03,600 TO INFRASTRUCTURE OF PROGRAMS 3448 02:26:03,600 --> 02:26:08,280 ALREADY EXISTING LIKE CEPA THAT 3449 02:26:08,280 --> 02:26:09,280 LOOKS AT K-12, CONDITIONING, 3450 02:26:09,280 --> 02:26:10,560 TALKING TO STUDENTS ABOUT 3451 02:26:10,560 --> 02:26:13,680 IMRTANCE OF BIOMEDICALRESEARCH,H 3452 02:26:13,680 --> 02:26:15,640 COMPONENT WILL ONLY HELP US 3453 02:26:15,640 --> 02:26:17,880 DEVELOP THAT PIPELINE. 3454 02:26:17,880 --> 02:26:20,640 WHEN WE LAUNCH THE DEIA 3455 02:26:20,640 --> 02:26:22,920 INITIATIVE IT WILL COME TOGETHER 3456 02:26:22,920 --> 02:26:24,760 VERY WELL. 3457 02:26:24,760 --> 02:26:26,080 I CAN'T GO THROUGH EACH BACKUP 3458 02:26:26,080 --> 02:26:27,840 THE POWERPOINT IS AVAILABLE FOR 3459 02:26:27,840 --> 02:26:31,320 YOUR REFERENCE AS WE FINISH. 3460 02:26:31,320 --> 02:26:36,400 VERY PLEASED AT THIS TRIAL GRANT 3461 02:26:36,400 --> 02:26:38,800 WE FUNDED, THEY PUT A LOT OF 3462 02:26:38,800 --> 02:26:41,760 WORK INTO THIS. 3463 02:26:41,760 --> 02:26:48,440 TEN TRAINEES A YEAR FROM 3464 02:26:48,440 --> 02:26:54,880 UNDERREPRESENTED BACKGROUND, 3465 02:26:54,880 --> 02:26:56,320 EARLY STAGE INDIVIDUALS, 3466 02:26:56,320 --> 02:26:57,280 HANDS-ON EXPERIENCED MENTORS, 3467 02:26:57,280 --> 02:26:59,480 YOU CAN SEE JACK AND FRANCISCO 3468 02:26:59,480 --> 02:27:01,360 AND OTHERS THAT ARE STALWARTS IN 3469 02:27:01,360 --> 02:27:03,400 OUR FIELD. 3470 02:27:03,400 --> 02:27:05,280 THE GOOD NEWS LOOK AT THE 3471 02:27:05,280 --> 02:27:09,520 SUCCESS RATES OF THE PROGRAM. 3472 02:27:09,520 --> 02:27:13,880 YOU CAN SEE FIVE INDIVIDUALS, 3473 02:27:13,880 --> 02:27:15,440 ELEVEN ACTUALLY, THAT WERE 3474 02:27:15,440 --> 02:27:18,400 FUNDED, SUCCESSFUL IN COMING UP 3475 02:27:18,400 --> 02:27:20,360 WITH A COMPETITIVE GRANT 3476 02:27:20,360 --> 02:27:21,280 APPLICATION, VERY ENCOURAGING 3477 02:27:21,280 --> 02:27:23,800 TREND FOR US TO BE LOOKING AT 3478 02:27:23,800 --> 02:27:28,120 AND MAYBE EXPLORING IN TERMS OF 3479 02:27:28,120 --> 02:27:28,920 EXPANSION. 3480 02:27:28,920 --> 02:27:30,120 ANOTHER SOLUTION OR STRATEGY TO 3481 02:27:30,120 --> 02:27:32,160 MAKE SURE WE HAVE LEADERSHIP 3482 02:27:32,160 --> 02:27:35,680 TEAM IN PLACE THAT REFLECTS THE 3483 02:27:35,680 --> 02:27:37,120 DIVERSITY OF OUR RESEARCH 3484 02:27:37,120 --> 02:27:39,320 PORTFOLIO AND OUR INTERESTS SO 3485 02:27:39,320 --> 02:27:47,840 JENNIFER HIT THE GROUND RUNNING. 3486 02:27:47,840 --> 02:27:50,640 I WOULD LOVE FOR YOU TO 3487 02:27:50,640 --> 02:27:53,320 CO-MODERATE WITH ME, PLANE IN 3488 02:27:53,320 --> 02:27:55,400 SEPTEMBER, SHE'S VERY KEEN ON 3489 02:27:55,400 --> 02:28:01,320 DEVELOPING A HEALTH DISPARITIES 3490 02:28:01,320 --> 02:28:05,240 RESEARCH PORTFOLIO, DEVELOPS 3491 02:28:05,240 --> 02:28:07,640 DIVERSITY INITIATIVES, WITH HER 3492 02:28:07,640 --> 02:28:11,480 OWN LAB IN NIAID WITH JEFF GOLD 3493 02:28:11,480 --> 02:28:13,640 AND HIS GROUP EXPLORING VIRAL 3494 02:28:13,640 --> 02:28:15,760 PATHOGENESIS AGAIN ALONG WITH 3495 02:28:15,760 --> 02:28:19,880 HEALTH DISPARITIES RESEARCH. 3496 02:28:19,880 --> 02:28:22,640 RENEE JOSKOW COMES WITH A WEALTH 3497 02:28:22,640 --> 02:28:25,680 OF EXPERIENCE WITH FEDERAL 3498 02:28:25,680 --> 02:28:27,240 AGENCIES UNDERSTANDING HOW 3499 02:28:27,240 --> 02:28:29,480 AGENCIES WORK, SHE HEADED ORAL 3500 02:28:29,480 --> 02:28:32,280 HEALTH DIVISION, HERE TO 3501 02:28:32,280 --> 02:28:35,920 ACTUALLY STRIKE UP AND DEVELOP 3502 02:28:35,920 --> 02:28:37,720 FROM SCRATCH NOVEL COLLABORATION 3503 02:28:37,720 --> 02:28:38,960 2000 IS TRANSFEDERAL AGENCIES. 3504 02:28:38,960 --> 02:28:41,040 YOU KNOW FROM THOSE DIAGRAMS I 3505 02:28:41,040 --> 02:28:44,760 SHOWED THAT WE CAN DO THINGS 3506 02:28:44,760 --> 02:28:50,880 APART FROM HRSA OR CDC AND CMS, 3507 02:28:50,880 --> 02:28:52,000 YOU KNOW, DEFINITELY 3508 02:28:52,000 --> 02:28:54,680 COLLABORATING ON WIN-WIN 3509 02:28:54,680 --> 02:28:56,360 INITIATIVES IS GOING TO BE WHERE 3510 02:28:56,360 --> 02:28:58,640 WE MOVE. 3511 02:28:58,640 --> 02:29:00,920 VERY HAPPY TO SAY THE PROGRAM IS 3512 02:29:00,920 --> 02:29:02,840 ROBUST, LARRY TALKED ABOUT SO I 3513 02:29:02,840 --> 02:29:06,240 WON'T SAY MUCH MORE, BUT WHAT 3514 02:29:06,240 --> 02:29:09,040 MATT HAS DONE IS TO CREATE SENSE 3515 02:29:09,040 --> 02:29:12,560 OF COMMUNITY AMONGST 3516 02:29:12,560 --> 02:29:14,360 INVESTIGATORS, TRAINEES, STAFF, 3517 02:29:14,360 --> 02:29:18,920 VERY HAPPY ENVIRONMENT AND HIS 3518 02:29:18,920 --> 02:29:22,320 EFFORT TO DIVERSITY IS 3519 02:29:22,320 --> 02:29:22,680 COMMENDABLE. 3520 02:29:22,680 --> 02:29:25,240 NOW WE HAVE SEVEN PRINCIPAL 3521 02:29:25,240 --> 02:29:26,240 INVESTIGATORS WHO ARE APPOINTED 3522 02:29:26,240 --> 02:29:28,600 IN THE DIVISION OF INTRAMURAL 3523 02:29:28,600 --> 02:29:29,960 RESEARCH BUT WORK IN 3524 02:29:29,960 --> 02:29:37,200 COLLABORATION WITH THE CLINICAL 3525 02:29:37,200 --> 02:29:37,760 CENTER. 3526 02:29:37,760 --> 02:29:40,160 LOADS OF EXAMPLES OF PARADIGM 3527 02:29:40,160 --> 02:29:43,880 SHIFTING WORK. 3528 02:29:43,880 --> 02:29:48,040 THE WORK IS PARADIGM SHIFTING, 3529 02:29:48,040 --> 02:29:54,280 MOVING TOWARDS IDENTIFYING ONE 3530 02:29:54,280 --> 02:29:55,680 NEUROMODULATOR, CDK5, WOULD 3531 02:29:55,680 --> 02:29:57,800 ALLEVIATE PAIN, A POSSIBLE 3532 02:29:57,800 --> 02:29:59,320 NON-OPIOID ALTERNATIVE FOR PAIN 3533 02:29:59,320 --> 02:30:00,200 MANAGEMENT, TIMELY. 3534 02:30:00,200 --> 02:30:04,560 IT INVOLVES MANY YEARS OF HARD 3535 02:30:04,560 --> 02:30:06,520 WORK THAT ASHOK HAS DONE IN THE 3536 02:30:06,520 --> 02:30:07,880 FIELD OF NEUROSCIENCE. 3537 02:30:07,880 --> 02:30:10,880 YOU HEARD FROM NIKI, I WAS GOING 3538 02:30:10,880 --> 02:30:13,200 TO INTRODUCE HER. 3539 02:30:13,200 --> 02:30:16,280 THE REASON, WE LOOKED AT PAIN 3540 02:30:16,280 --> 02:30:17,480 PORTFOLIO IN PERIODONTAL BIOLOGY 3541 02:30:17,480 --> 02:30:21,040 AND WE FIND THAT IT IS NOT AS 3542 02:30:21,040 --> 02:30:22,400 ROBUST AS COULD BE. 3543 02:30:22,400 --> 02:30:24,040 WE CONSIDERED ALL THE MANY 3544 02:30:24,040 --> 02:30:27,960 STUDIES THAT HAVE BEEN SPONSORED 3545 02:30:27,960 --> 02:30:29,720 ON REGENERATING, IT'S NOT THAT 3546 02:30:29,720 --> 02:30:31,320 EVERYTHING HAS TO SUCCEED FOR US 3547 02:30:31,320 --> 02:30:33,520 TO FEEL GOOD, IT'S THE FACT HOW 3548 02:30:33,520 --> 02:30:36,680 MUCH DO WE UNDERSTAND OF THE 3549 02:30:36,680 --> 02:30:42,280 SYSTEMS APPROACH OF THE DEEP 3550 02:30:42,280 --> 02:30:44,080 PHENOTYPING, STRATIFICATION 3551 02:30:44,080 --> 02:30:48,120 BASED ON UNDERLYING MOLECULAR 3552 02:30:48,120 --> 02:30:50,240 EVENTS. 3553 02:30:50,240 --> 02:30:52,840 I THINK WHAT NIKI IS MOVING THE 3554 02:30:52,840 --> 02:30:55,560 THEME FORWARD IS THAT CONCEPT 3555 02:30:55,560 --> 02:31:03,560 THAT NEEDS TO BE UNDERSTOOD. 3556 02:31:03,560 --> 02:31:04,320 ROBUST EXTRAMURAL PROGRAM IS 3557 02:31:04,320 --> 02:31:10,120 DIVERSE AND THE CHALLENGE HERE, 3558 02:31:10,120 --> 02:31:11,680 THIS IS THE CHALLENGE, ARE WE 3559 02:31:11,680 --> 02:31:12,560 CONNECTING THE DOTS? 3560 02:31:12,560 --> 02:31:16,720 IF WE WORK IN THE AREA OF CARIES 3561 02:31:16,720 --> 02:31:19,240 AND FOCUS ON EARLY INTERVENTION 3562 02:31:19,240 --> 02:31:20,920 STRATEGY, ARE WE CONNECTING THAT 3563 02:31:20,920 --> 02:31:22,120 TO THE MICROBIOME THAT SOMEONE 3564 02:31:22,120 --> 02:31:32,560 ELSE IS WORKING ON OR PRO 3565 02:31:33,640 --> 02:31:33,920 BIOTICS. 3566 02:31:33,920 --> 02:31:35,560 WE'VE BEEN SEEKING TO DEVELOP 3567 02:31:35,560 --> 02:31:37,520 SYSTEMS APPROACHES THAT TAKE 3568 02:31:37,520 --> 02:31:39,120 SOMETHING FROM START TO FINISH, 3569 02:31:39,120 --> 02:31:40,080 IN A GIVEN COMMUNITY. 3570 02:31:40,080 --> 02:31:42,160 I JUST GOT BACK FROM THE 3571 02:31:42,160 --> 02:31:46,320 UNIVERSITY OF TEXAS IN SAN 3572 02:31:46,320 --> 02:31:48,840 ANTONIO, SO IMPRESSED WITH THEIR 3573 02:31:48,840 --> 02:31:51,240 QUIET UNDERSTATED BUT STRONG 3574 02:31:51,240 --> 02:31:53,880 RESEARCH PORTFOLIO. 3575 02:31:53,880 --> 02:31:56,280 I'M NOT FAVORING ONE INSTITUTE, 3576 02:31:56,280 --> 02:32:00,320 JUST SOMETHING I PICKED UP, 3577 02:32:00,320 --> 02:32:01,320 STRENGTHS, OPPORTUNITIES, THAT 3578 02:32:01,320 --> 02:32:02,720 HUGE HISPANIC POPULATION IN 3579 02:32:02,720 --> 02:32:06,000 SOUTH TEXAS, THAT COULD BE 3580 02:32:06,000 --> 02:32:07,840 FOLLOWED FROM EARLY CHILDHOOD TO 3581 02:32:07,840 --> 02:32:10,480 ROOT CARIES, TO THE VERY AGE, IS 3582 02:32:10,480 --> 02:32:19,440 AVAILABLE FOR US TO EXPLORE 3583 02:32:19,440 --> 02:32:21,160 USING A MULTI-DISCIPLINARY 3584 02:32:21,160 --> 02:32:21,480 APPROACH. 3585 02:32:21,480 --> 02:32:22,040 A WONDERFUL EXAMPLE. 3586 02:32:22,040 --> 02:32:24,720 THIS IS A WONDERFUL ARTICLE. 3587 02:32:24,720 --> 02:32:29,640 IT SPEAKS TO THE CROSS-CUTTING 3588 02:32:29,640 --> 02:32:33,560 THEME WE COULD UNDERSTAND FUNDED 3589 02:32:33,560 --> 02:32:34,960 RESEARCH ACROSS THE BODY. 3590 02:32:34,960 --> 02:32:43,000 I WANTED TO HIGHLIGHT THIS 3591 02:32:43,000 --> 02:32:43,480 PARTICULARLY. 3592 02:32:43,480 --> 02:32:45,280 HOW DO WE WORK WITH P.I.s SUCH 3593 02:32:45,280 --> 02:32:49,000 THAT THEY MOVE INTO THE NEW ERA 3594 02:32:49,000 --> 02:32:49,960 OF TRANSLATION, MAKING 3595 02:32:49,960 --> 02:32:56,360 DIFFERENCE TO OUR PATIENTS. 3596 02:32:56,360 --> 02:33:00,720 WE HAVE AS YOU KNOW THE HUB 3597 02:33:00,720 --> 02:33:03,120 BASED IN ALABAMA, THE 3598 02:33:03,120 --> 02:33:03,800 REGENERATIVE MEDICINE CONSORTIA 3599 02:33:03,800 --> 02:33:06,640 IN THE WEST COAST AND NORTHEAST 3600 02:33:06,640 --> 02:33:07,960 AND MICHIGAN. 3601 02:33:07,960 --> 02:33:10,640 WE HAVE FACEBASE IN CALIFORNIA, 3602 02:33:10,640 --> 02:33:15,480 SOON TO COME TEMPORO 3603 02:33:15,480 --> 02:33:16,200 TEMPOROMANDIBULAR JOINT 3604 02:33:16,200 --> 02:33:16,520 DYSFUNCTION. 3605 02:33:16,520 --> 02:33:18,880 IF YOU LOOK AT THIS, ONE WOULD 3606 02:33:18,880 --> 02:33:24,920 ASK, I'M BEING DIRECT HERE, HOW 3607 02:33:24,920 --> 02:33:28,400 MUCH IS THE PBRN, IS THERE AN 3608 02:33:28,400 --> 02:33:30,480 OPPORTUNITY FOR PBRN TO EXPAND 3609 02:33:30,480 --> 02:33:33,360 INTO COMMUNITY HEALTH INTEREST 3610 02:33:33,360 --> 02:33:35,400 AREAS THAT HAVE PUBLIC HEALTH 3611 02:33:35,400 --> 02:33:35,640 CONCERN? 3612 02:33:35,640 --> 02:33:39,160 COULD WE LEVERAGE FROM EXISTING 3613 02:33:39,160 --> 02:33:40,960 PLATFORMS THAT THE PANDEMIC 3614 02:33:40,960 --> 02:33:42,840 FIELD, FOR EXAMPLE BOTTOM LEFT, 3615 02:33:42,840 --> 02:33:45,040 AN INFRASTRUCTURE THAT CAME FROM 3616 02:33:45,040 --> 02:33:47,680 THE NEEDS FROM US UNDERSTANDING 3617 02:33:47,680 --> 02:33:49,080 DEFICIENCIES AS A COUNTRY, THAT 3618 02:33:49,080 --> 02:33:50,400 WE DIDN'T HAVE COMMUNITY 3619 02:33:50,400 --> 02:33:52,960 ENGAGEMENT AS ITS BEST. 3620 02:33:52,960 --> 02:33:55,880 WE HAD NOT FORGED RELATIONSHIP 3621 02:33:55,880 --> 02:33:57,240 WAS COMMUNITY LEADERS, SCIENCE 3622 02:33:57,240 --> 02:33:58,960 COMMUNICATION WAS LACKING, HENCE 3623 02:33:58,960 --> 02:34:01,800 THAT UNDERSTANDING OF TESTING 3624 02:34:01,800 --> 02:34:03,240 AND INFECTIOUS DISEASES AND 3625 02:34:03,240 --> 02:34:06,400 VACCINES OBVIOUSLY CAME A HUGE 3626 02:34:06,400 --> 02:34:06,840 PROBLEM. 3627 02:34:06,840 --> 02:34:10,000 NOW THESE CONNECTIONS WITH THIS 3628 02:34:10,000 --> 02:34:11,880 RELIGIOUS LEADERS, FAITH-BASED 3629 02:34:11,880 --> 02:34:13,320 SCHOOL BOARDS, LOCAL MAYORS AND 3630 02:34:13,320 --> 02:34:14,720 GOVERNMENTS ARE IN PLACE IN MANY 3631 02:34:14,720 --> 02:34:17,720 PARTS OF THE COUNTRY AND THE 3632 02:34:17,720 --> 02:34:19,760 PLAN IS COULD WE LEVERAGE FROM 3633 02:34:19,760 --> 02:34:24,280 THESE PLATFORMS, THAT OFFERS AT 3634 02:34:24,280 --> 02:34:25,920 LEAST 450,000 PATIENTS, DIVERSE 3635 02:34:25,920 --> 02:34:28,800 BACKGROUNDS AND RECORDS TO HAVE 3636 02:34:28,800 --> 02:34:30,840 THE PBRN TAKE PART IN. 3637 02:34:30,840 --> 02:34:36,080 OF COURSE THE LARGER CONCEPT OF 3638 02:34:36,080 --> 02:34:38,640 DIABETES, OBESITY, ALZHEIMER'S, 3639 02:34:38,640 --> 02:34:41,480 ALL OF WHICH WOULD GAIN FROM 3640 02:34:41,480 --> 02:34:43,640 ORAL HEALTH INTERVENTION I WOULD 3641 02:34:43,640 --> 02:34:44,120 SAY. 3642 02:34:44,120 --> 02:34:45,960 SO THE PLAN IS, THE CHARGES 3643 02:34:45,960 --> 02:34:48,560 LET'S THINK ABOUT THE FUTURE AS 3644 02:34:48,560 --> 02:34:50,640 WE CAPITALIZE ON THESE WONDERFUL 3645 02:34:50,640 --> 02:34:52,000 INITIATIVES THAT WE'VE INVESTED 3646 02:34:52,000 --> 02:34:52,280 IN. 3647 02:34:52,280 --> 02:34:55,160 AND IN THAT SAME LIGHT AND IN 3648 02:34:55,160 --> 02:34:57,000 ALMOST IN THE CONTEXT OF WHAT I 3649 02:34:57,000 --> 02:34:59,200 ASKED LARRY ABOUT DENTAL SCHOOL 3650 02:34:59,200 --> 02:35:00,280 AND INVESTING, TAKING A NEW LOOK 3651 02:35:00,280 --> 02:35:02,920 AT WHAT IS BEST SCIENCE, IT'S 3652 02:35:02,920 --> 02:35:07,360 NOT ALWAYS AT THE BENCH, RIGHT? 3653 02:35:07,360 --> 02:35:10,320 WE USED TO THINK THAT WAY IN 3654 02:35:10,320 --> 02:35:11,680 REDUCTIONIST APPROACH BUT WE'VE 3655 02:35:11,680 --> 02:35:14,240 GOT TO THINK OF EXPANDING THE 3656 02:35:14,240 --> 02:35:15,160 WORKFORCE, ENGAGING CLINICIANS 3657 02:35:15,160 --> 02:35:16,240 TO THE FULLEST. 3658 02:35:16,240 --> 02:35:18,200 THE BEST WAY TO START THAT CAN 3659 02:35:18,200 --> 02:35:20,880 ONLY BENEFIT THE NATIONAL PBRN 3660 02:35:20,880 --> 02:35:22,360 TO CREATE THAT CULTURE WITH THE 3661 02:35:22,360 --> 02:35:23,680 DENTAL SCHOOL ENVIRONMENT, THAT 3662 02:35:23,680 --> 02:35:25,400 OFFERS A SAFETY NET TO PROBABLY 3663 02:35:25,400 --> 02:35:27,400 THE MOST DIVERSE OF ALL PATIENT 3664 02:35:27,400 --> 02:35:31,800 POPULATIONS THAT EXIST IN THE 3665 02:35:31,800 --> 02:35:32,440 COUNTRY. 3666 02:35:32,440 --> 02:35:33,640 BOTH DISEASE-WISE, RACE, ETHNIC, 3667 02:35:33,640 --> 02:35:34,640 SPECIAL NEEDS PATIENTS, WE HAVE 3668 02:35:34,640 --> 02:35:37,120 IT IN DENTAL SCHOOL SETTING, 3669 02:35:37,120 --> 02:35:41,520 GETTING BACK INVOLVED WHO ARE 3670 02:35:41,520 --> 02:35:46,800 TYPICALLY MANNING CLINICAL FOLD, 3671 02:35:46,800 --> 02:35:47,760 LEVERAGING FROM PROGRAMS COULD 3672 02:35:47,760 --> 02:35:52,040 ENGAGE IN CREATING NEW KNOWLEDGE 3673 02:35:52,040 --> 02:35:53,560 STUDENTS EXPERIENCE IN TREATING 3674 02:35:53,560 --> 02:35:53,840 PATIENTS. 3675 02:35:53,840 --> 02:35:56,080 THAT RFA SOON TO BE RELEASED, WE 3676 02:35:56,080 --> 02:35:58,560 HAVE A WEBINAR DESCRIBING IT IN 3677 02:35:58,560 --> 02:35:59,360 GREAT DETAIL. 3678 02:35:59,360 --> 02:36:04,000 AND SO IT WILL BE OPEN TO 3679 02:36:04,000 --> 02:36:05,720 QUESTION AND ANSWERS, OUR SENSE 3680 02:36:05,720 --> 02:36:12,400 IS THE INTEREST IS VERY HIGH. 3681 02:36:12,400 --> 02:36:14,920 IT WILL OPERATE AS A PLANNING 3682 02:36:14,920 --> 02:36:17,000 PHASE AND THEN GO INTO 3683 02:36:17,000 --> 02:36:18,000 IMPLEMENTATION PHASE BUT IT'S 3684 02:36:18,000 --> 02:36:20,280 INTENDED TO BE A TRANSFORMATIVE 3685 02:36:20,280 --> 02:36:20,800 MECHANISM. 3686 02:36:20,800 --> 02:36:22,400 AND NO DOUBT THERE WILL BE 3687 02:36:22,400 --> 02:36:26,200 GLITCHES BUT WE ARE GOING TO AS 3688 02:36:26,200 --> 02:36:34,440 BEST AS POSSIBLE MITIGATE THESE. 3689 02:36:34,440 --> 02:36:40,440 WE HAVE THROUGH GREAT SUCCESS IN 3690 02:36:40,440 --> 02:36:42,680 THE DOC PROGRAM, TO HAVE MORE 3691 02:36:42,680 --> 02:36:44,520 FDA APPROVAL STAGES, YOU CAN SEE 3692 02:36:44,520 --> 02:36:46,160 THAT'S ACTUALLY HAPPENING. 3693 02:36:46,160 --> 02:36:47,960 I'VE CHALLENGED THIS GROUP TO 3694 02:36:47,960 --> 02:36:50,120 USE THE SYSTEMS APPROACH. 3695 02:36:50,120 --> 02:36:52,440 SIMILAR TO WHAT NIKI HAS SET US 3696 02:36:52,440 --> 02:36:54,160 ON, THAT PATH. 3697 02:36:54,160 --> 02:36:54,920 SO THAT WITH THAT UNDERSTANDING 3698 02:36:54,920 --> 02:36:56,920 WE CAN COME UP WITH EFFECTIVE 3699 02:36:56,920 --> 02:36:59,480 TECHNOLOGIES AT THE RIGHT TIME 3700 02:36:59,480 --> 02:37:01,320 FOR THE RIGHT PATIENTS. 3701 02:37:01,320 --> 02:37:03,240 USING THAT KIND OF APPROACH IS 3702 02:37:03,240 --> 02:37:06,400 IMPORTANT AS WE THINK OF THE 3703 02:37:06,400 --> 02:37:07,400 STAGE SPECIFICITY OF SUCH 3704 02:37:07,400 --> 02:37:07,800 DISEASE. 3705 02:37:07,800 --> 02:37:11,920 THAT WOULD BE THE CHALLENGE. 3706 02:37:11,920 --> 02:37:13,760 AND YOU CAN SEE FROM 3707 02:37:13,760 --> 02:37:15,640 INSTITUTIONS TO TISSUES AND TO 3708 02:37:15,640 --> 02:37:18,920 TECHNOLOGIES THAT HAS BEEN QUITE 3709 02:37:18,920 --> 02:37:19,840 DIVERSE AND TRANSLATIONAL. 3710 02:37:19,840 --> 02:37:26,560 IT'S A WONDERFUL PATH TO BE ON. 3711 02:37:26,560 --> 02:37:28,440 I'M PLEASED WITH SAFE SPACE AND 3712 02:37:28,440 --> 02:37:29,320 AMOUNT OF REPOSITORY DATA WE 3713 02:37:29,320 --> 02:37:29,680 HAVE. 3714 02:37:29,680 --> 02:37:31,360 THE QUESTION IS HOW DO WE MAKE 3715 02:37:31,360 --> 02:37:35,000 IT USEFUL TO CLINICIAN WHO IS 3716 02:37:35,000 --> 02:37:38,280 HAVE -- CLINICIAN WHO IS HAVE A 3717 02:37:38,280 --> 02:37:39,680 HARD TIME WITH SUBTLETIES, COULD 3718 02:37:39,680 --> 02:37:42,800 WE USE A.I. MACHINE LEARNING 3719 02:37:42,800 --> 02:37:47,840 TOOLS, CONNECT THIS DATABASE, 3720 02:37:47,840 --> 02:37:49,800 INTO A LARGER REPOSITORY SO WE 3721 02:37:49,800 --> 02:37:52,880 CAN CONNECT BOTH SINGLE GENE 3722 02:37:52,880 --> 02:37:53,440 DISORDERS AND SYNDROMIC 3723 02:37:53,440 --> 02:37:57,680 CONDITIONS TO THE BENEFIT OF 3724 02:37:57,680 --> 02:37:57,920 PATIENTS. 3725 02:37:57,920 --> 02:38:00,520 THIS IS ONE OF THE INTEGRATED 3726 02:38:00,520 --> 02:38:02,160 SERVICES THAT THIS PARTICULAR 3727 02:38:02,160 --> 02:38:03,400 PROGRAM OFFERS CURRENTLY. 3728 02:38:03,400 --> 02:38:07,440 AND THE QUESTION IS CAN WE MAKE 3729 02:38:07,440 --> 02:38:10,160 IT INTEROPERABLE TO WHAT NIH IS 3730 02:38:10,160 --> 02:38:13,440 SOON TO OFFER AS OPEN ACCESS 3731 02:38:13,440 --> 02:38:16,000 CLOUD-BASED PLATFORM 3732 02:38:16,000 --> 02:38:17,720 TECHNOLOGIES, SAME EXISTS 3733 02:38:17,720 --> 02:38:19,120 WITHOUT DIR THAT HAS MANY 3734 02:38:19,120 --> 02:38:21,320 DATASETS THAT NEED TO BE MERGED 3735 02:38:21,320 --> 02:38:27,120 INTO THESE OPEN ACCESS PLAT 3736 02:38:27,120 --> 02:38:27,440 FORMS. 3737 02:38:27,440 --> 02:38:34,560 THIS IS EXAMPLES WHAT WE'RE 3738 02:38:34,560 --> 02:38:36,640 MAKING PROGRESS, AMP-AIM, AN 3739 02:38:36,640 --> 02:38:37,160 UNPRECEDENTED PARTNERSHIP 3740 02:38:37,160 --> 02:38:38,280 BETWEEN INDUSTRY, GOVERNMENT 3741 02:38:38,280 --> 02:38:40,560 WHICH WAS NIH, FDA, AND 3742 02:38:40,560 --> 02:38:45,840 ACADEMICS, TOE THE -- TO THE 3743 02:38:45,840 --> 02:38:49,160 TABLE TO SOLVE PROBLEMS OF 3744 02:38:49,160 --> 02:38:50,320 COMPLEX DISEASES, ALZHEIMER'S, 3745 02:38:50,320 --> 02:38:52,000 DIABETES. 3746 02:38:52,000 --> 02:38:57,320 PROGRESS MADE IN AUTOIMMUNE 3747 02:38:57,320 --> 02:38:58,120 DOMAIN WAS WHAT ENCOURAGED 3748 02:38:58,120 --> 02:38:59,640 FRANCIS COLLINS AND LARRY TO 3749 02:38:59,640 --> 02:39:04,760 CONSIDER SJOGREN'S AS PART OF 3750 02:39:04,760 --> 02:39:05,200 THIS. 3751 02:39:05,200 --> 02:39:08,520 WE WERE VERY INVOLVED, ONE OF 3752 02:39:08,520 --> 02:39:11,880 THE FIRST GIFTS WHEN I ARRIVED 3753 02:39:11,880 --> 02:39:13,960 IN OCTOBER OF 2020, LOOKING AT 3754 02:39:13,960 --> 02:39:17,120 WHAT WE HAD CURRENTLY, HUGE 3755 02:39:17,120 --> 02:39:18,680 REPOSITORY, 4,000 PATIENTS WITH 3756 02:39:18,680 --> 02:39:21,520 SAMPLES AND CONNECT THE DOTS AS 3757 02:39:21,520 --> 02:39:24,280 BEST WE CAN, THAT WILL BE AS YOU 3758 02:39:24,280 --> 02:39:26,240 CAN SEE A MULTI-INSTITUTIONAL 3759 02:39:26,240 --> 02:39:32,360 EFFORT BASED AT UCSF, A 3760 02:39:32,360 --> 02:39:33,680 PARTNERSHIP, AND INTRAMURAL 3761 02:39:33,680 --> 02:39:34,760 PROGRAM WITH 35-YEAR HISTORY 3762 02:39:34,760 --> 02:39:36,480 CONTRIBUTING TO THE 3763 02:39:36,480 --> 02:39:39,040 UNDERSTANDING OF SALIVA, ITS 3764 02:39:39,040 --> 02:39:42,120 BIOLOGY AND REGENERATION, AND 3765 02:39:42,120 --> 02:39:47,880 GENE THERAPY TO ACTUALLY 3766 02:39:47,880 --> 02:39:49,240 OVERCOME RADIATION DAMAGE, IN 3767 02:39:49,240 --> 02:39:53,600 PHASE 2 RIGHT NOW. 3768 02:39:53,600 --> 02:40:01,360 THIS IS AN EXAMPLE OF THE 3769 02:40:01,360 --> 02:40:02,360 PHASES, DISASSOCIATED, 3770 02:40:02,360 --> 02:40:03,840 DESEGREGATING THE DISEASE AT 3771 02:40:03,840 --> 02:40:05,480 EVERY STAGE, ASSOCIATING THE 3772 02:40:05,480 --> 02:40:07,480 PHENOTYPE AND PUTTING IT ALL 3773 02:40:07,480 --> 02:40:09,960 BACK TOGETHER WITH THE HOPE 3774 02:40:09,960 --> 02:40:11,960 THERE WOULD BE THERAPIES FOR 3775 02:40:11,960 --> 02:40:15,040 EACH STAGE OF SJOGREN'S 3776 02:40:15,040 --> 02:40:15,560 DEVELOPMENT. 3777 02:40:15,560 --> 02:40:17,680 NEEDLESS TO SAY EMERGENT ISSUES 3778 02:40:17,680 --> 02:40:20,600 AND TRENDS ARE VERY MUCH WHAT 3779 02:40:20,600 --> 02:40:23,240 NIDCR IS PREPARED TO APPROACH IN 3780 02:40:23,240 --> 02:40:31,880 A NIMBLE FACTION, YOUNG MALES 3781 02:40:31,880 --> 02:40:33,320 WERE MORE AFFECTED NOW, COULD 3782 02:40:33,320 --> 02:40:35,280 NOT BE -- IT WAS NOT PREDICTED 3783 02:40:35,280 --> 02:40:39,560 WHEN WE STARTED WITH THE VACCINE 3784 02:40:39,560 --> 02:40:41,680 THAT WE WERE THINKING TEENAGE 3785 02:40:41,680 --> 02:40:43,640 GIRLS WERE ONES TO BE 3786 02:40:43,640 --> 02:40:43,920 VACCINATED. 3787 02:40:43,920 --> 02:40:46,040 TURNS OUT THAT YOUNG MEN ARE 3788 02:40:46,040 --> 02:40:47,120 JUST AS PRONE. 3789 02:40:47,120 --> 02:40:49,640 I THINK THE RATIO IS SIX TIMES 3790 02:40:49,640 --> 02:40:52,480 MORE NOW THAN FEMALES, I 3791 02:40:52,480 --> 02:40:53,360 BELIEVE. 3792 02:40:53,360 --> 02:40:55,320 WE BROUGHT TOGETHER A THINK TANK 3793 02:40:55,320 --> 02:40:57,160 THAT NED SHARPLESS AND I KICKED 3794 02:40:57,160 --> 02:40:58,920 OFF, HE'S NO LONGER DIRECTOR, HE 3795 02:40:58,920 --> 02:41:00,480 DID STEP DOWN AS NCI DIRECTOR SO 3796 02:41:00,480 --> 02:41:02,320 WE SHOULD HAVE A NEW 3797 02:41:02,320 --> 02:41:03,400 PRESIDENTIAL APPOINTEE. 3798 02:41:03,400 --> 02:41:05,480 BUT VERY, VERY COMMITTED TO THIS 3799 02:41:05,480 --> 02:41:07,880 AREA, THAT WAS HIS CLINICAL AREA 3800 02:41:07,880 --> 02:41:09,040 OF INTEREST. 3801 02:41:09,040 --> 02:41:11,840 AND LOOK TO SEE, AGAIN, IN A 3802 02:41:11,840 --> 02:41:13,280 SYSTEMS APPROACH LET'S NOT HAVE 3803 02:41:13,280 --> 02:41:14,480 PREVENTION KIND OF GROUP WORKING 3804 02:41:14,480 --> 02:41:17,080 ON ONE END OF THE COUNTRY AND 3805 02:41:17,080 --> 02:41:19,720 SOMEONE BE LOOKING AT 3806 02:41:19,720 --> 02:41:20,920 PRE-DIAGNOSTICS OR BIOLOGIC 3807 02:41:20,920 --> 02:41:22,800 MARKERS IN ANOTHER END, AND 3808 02:41:22,800 --> 02:41:24,400 UNNECESSARY TALKING TO EACH 3809 02:41:24,400 --> 02:41:27,360 OTHER, LET'S COME TOGETHER IN A 3810 02:41:27,360 --> 02:41:29,920 SYSTEMS-WIDE APPROACH, SUCH THAT 3811 02:41:29,920 --> 02:41:31,440 WE ACTUALLY CAN REALLY DETECT 3812 02:41:31,440 --> 02:41:33,600 THIS DISEASE EARLY, PUT AN 3813 02:41:33,600 --> 02:41:35,160 EMPHASIS ON PREVENTION, AND COME 3814 02:41:35,160 --> 02:41:37,800 UP WITH TREATMENTS THAT ARE IN 3815 02:41:37,800 --> 02:41:39,000 FACT EFFECTIVE. 3816 02:41:39,000 --> 02:41:41,160 THIS IS ANOTHER IDEA THAT LARRY 3817 02:41:41,160 --> 02:41:43,360 DID EXPAND ON SO I WON'T TALK 3818 02:41:43,360 --> 02:41:46,200 ABOUT IT, TWO INITIATIVES THAT 3819 02:41:46,200 --> 02:41:49,680 NIDCR WAS AT THE TABLE FOR, 3820 02:41:49,680 --> 02:41:53,720 MYOFASCIAL, I WANT TO THANK 3821 02:41:53,720 --> 02:41:56,680 HELENE LANGEVIN, AND WHO ALSO 3822 02:41:56,680 --> 02:41:59,040 ACTUALLY SPEARHEADED THE REJOIN 3823 02:41:59,040 --> 02:41:59,560 INITIATIVE. 3824 02:41:59,560 --> 02:42:01,200 LARRY DIDN'T SAY THEY IS NOT A 3825 02:42:01,200 --> 02:42:02,800 SYSTEMS APPROACH. 3826 02:42:02,800 --> 02:42:06,280 IT'S A VERY DIRECT WAY OF 3827 02:42:06,280 --> 02:42:12,240 ANALYZING THE NEURAL OR 3828 02:42:12,240 --> 02:42:13,800 INNOVATION OF THE 3829 02:42:13,800 --> 02:42:15,120 TEMPOROMANDIBULAR JOINT COMPARED 3830 02:42:15,120 --> 02:42:16,280 TO KNEE JOINT, LOOKING AT 3831 02:42:16,280 --> 02:42:18,040 SIMILARITIES SO WE HAVE A SENSE 3832 02:42:18,040 --> 02:42:19,800 OF WHAT INNOVATION IS, PROBABLY 3833 02:42:19,800 --> 02:42:21,680 WOULD GIVE US PREDICTION FOR HOW 3834 02:42:21,680 --> 02:42:23,000 DISEASE PROGRESSES. 3835 02:42:23,000 --> 02:42:24,520 YOU CAN SEE THERE ARE TWO 3836 02:42:24,520 --> 02:42:26,600 IMPORTANT PAPERS IN THIS AREA 3837 02:42:26,600 --> 02:42:29,120 THAT HIGHLIGHT THE IMPORTANCE OF 3838 02:42:29,120 --> 02:42:30,520 THIS CONNECTION. 3839 02:42:30,520 --> 02:42:34,720 SO VERY SOON THERE IS GOING TO 3840 02:42:34,720 --> 02:42:36,560 BE THIS CONSORTIUM AGREEMENT 3841 02:42:36,560 --> 02:42:41,600 MOST LIKELY HUB AND SPOKE MODEL, 3842 02:42:41,600 --> 02:42:48,280 DECONSTRUCT AND RECONSTRUCT 3843 02:42:48,280 --> 02:42:51,240 TMJ -- TMD, SUCH THAT WE BRING 3844 02:42:51,240 --> 02:42:53,440 RELIEF FROM PATIENTS, A 3845 02:42:53,440 --> 02:42:56,400 DEBILITATING CHRISTIANS THAT -- 3846 02:42:56,400 --> 02:43:06,920 CONDITION THAT WILL OF -- IT 3847 02:43:06,920 --> 02:43:11,720 FITS INTO THE PAIN REALM AND WE 3848 02:43:11,720 --> 02:43:16,520 INTEND TO LEVERAGE THROUGH 3849 02:43:16,520 --> 02:43:18,840 "HEAL" SO WE PRESENT THE 3850 02:43:18,840 --> 02:43:20,440 PORTFOLIO TO OUR LEGISLATORS FOR 3851 02:43:20,440 --> 02:43:21,440 CONSIDERATION, THAT THIS IS 3852 02:43:21,440 --> 02:43:21,840 IMPORTANT. 3853 02:43:21,840 --> 02:43:23,840 AND YOU CAN SEE JUST LOOKING AT 3854 02:43:23,840 --> 02:43:26,480 WHAT WE HAVE IN FRONT OF US, IN 3855 02:43:26,480 --> 02:43:28,080 TERMS OF PAIN, THERE'S A LOT 3856 02:43:28,080 --> 02:43:31,440 MORE PROGRESS THAT IS NEEDED, 3857 02:43:31,440 --> 02:43:32,960 MUCH GREATER INVESTMENT, ALL THE 3858 02:43:32,960 --> 02:43:34,480 KINDS OF PAIN. 3859 02:43:34,480 --> 02:43:37,440 WE I THINK MIGHT HAVE THE BEST 3860 02:43:37,440 --> 02:43:40,080 BIOLOGICAL MODELS, WE ALSO HAVE 3861 02:43:40,080 --> 02:43:41,840 THE MOST CHALLENGING SYSTEM TO 3862 02:43:41,840 --> 02:43:43,560 CONSIDER, RIGHT? 3863 02:43:43,560 --> 02:43:46,880 A TOOTH THAT IS COMPLETELY 3864 02:43:46,880 --> 02:43:54,120 ENCASED BY THE HARDEST TISSUE IN 3865 02:43:54,120 --> 02:43:55,520 MAMMALIAN SYSTEMS, MRI IMAGING 3866 02:43:55,520 --> 02:43:59,760 TECHNOLOGY ALSO, COULD IT HELP 3867 02:43:59,760 --> 02:44:03,160 US DICTATE TREATMENT, REVERSIBLE 3868 02:44:03,160 --> 02:44:04,800 VERSUS IRREVERSE ABLE, MITIGATE 3869 02:44:04,800 --> 02:44:06,440 PAIN, PREVENT PULP FROM 3870 02:44:06,440 --> 02:44:10,280 NECROSING AND START THE SPIRAL 3871 02:44:10,280 --> 02:44:12,000 OF ROOT CANAL THERAPY, CROWN, 3872 02:44:12,000 --> 02:44:13,160 PROBABLY LEADING TO IMPLANT IN 3873 02:44:13,160 --> 02:44:14,120 THE END. 3874 02:44:14,120 --> 02:44:17,480 THERE'S A CYCLE THAT NEEDS TO BE 3875 02:44:17,480 --> 02:44:18,080 BROKEN. 3876 02:44:18,080 --> 02:44:20,880 PAIN IN CHILDREN WITH 3877 02:44:20,880 --> 02:44:22,960 CRANIOFACIAL DISORDERS, OPIOIDS 3878 02:44:22,960 --> 02:44:25,040 AND CONSEQUENCES, ORAL CANCER 3879 02:44:25,040 --> 02:44:26,360 PREVENTION AND PAIN, 3880 02:44:26,360 --> 02:44:27,360 RECONSTRUCTION AFTER ORAL 3881 02:44:27,360 --> 02:44:29,080 CANCER, ALL OF WHICH I THINK 3882 02:44:29,080 --> 02:44:36,000 WE'RE GOING TO PUT TOGETHER IN A 3883 02:44:36,000 --> 02:44:40,080 PORTFOLIO TO MAKE AVAILABLE TO 3884 02:44:40,080 --> 02:44:40,720 FUNDING SOURCES. 3885 02:44:40,720 --> 02:44:43,440 SO WHEN I TOOK A STEP BACK AND 3886 02:44:43,440 --> 02:44:44,640 JENNIFER HELPED WITH THIS SLIDE 3887 02:44:44,640 --> 02:44:46,080 WE THINK IN ORDER FOR ORAL 3888 02:44:46,080 --> 02:44:48,560 HEALTH TO BE AVAILABLE FOR ALL 3889 02:44:48,560 --> 02:44:52,880 IT DOES TAKE ALL OF US. 3890 02:44:52,880 --> 02:44:54,960 I DON'T MEAN JUST THE PRECISION 3891 02:44:54,960 --> 02:44:55,760 MEDICINE INITIATIVE, IT'S REALLY 3892 02:44:55,760 --> 02:44:56,400 ALL OF US. 3893 02:44:56,400 --> 02:44:58,760 IN T AREA AS I WILL PREVENT 3894 02:44:58,760 --> 02:45:01,040 TOMORROW WE NEED TO BE AT THE 3895 02:45:01,040 --> 02:45:01,240 TABLE. 3896 02:45:01,240 --> 02:45:05,840 IT'S MUCH MORE DIFFICULT TO 3897 02:45:05,840 --> 02:45:06,280 RETROFIT. 3898 02:45:06,280 --> 02:45:08,040 WE WANT TO BE PRO-ACTIVE AND 3899 02:45:08,040 --> 02:45:09,080 MAKE SURE THERE'S AN 3900 02:45:09,080 --> 02:45:11,080 UNDERSTANDING THAT IF ORAL 3901 02:45:11,080 --> 02:45:14,240 HEALTH IS INCLUDED, THAT OVERALL 3902 02:45:14,240 --> 02:45:16,120 HEALTH OUTCOMES ARE GOING TO 3903 02:45:16,120 --> 02:45:16,600 IMPROVE. 3904 02:45:16,600 --> 02:45:18,640 AND THAT WE DO HAVE A RIGHT. 3905 02:45:18,640 --> 02:45:19,440 WE ARE CONNECTED THROUGH THE 3906 02:45:19,440 --> 02:45:21,920 REST OF THE BODY. 3907 02:45:21,920 --> 02:45:25,360 THAT'S GOING TO BE MADE VERY 3908 02:45:25,360 --> 02:45:26,520 CLEAR AND VERY INVITATIONAL 3909 02:45:26,520 --> 02:45:29,440 MANNER SO WE MAKE CONNECTIONS 3910 02:45:29,440 --> 02:45:32,400 FOR BENEFIT OF PEOPLE WE SERVE. 3911 02:45:32,400 --> 02:45:36,040 AGAIN, WE FACE THAT NEXT 25 3912 02:45:36,040 --> 02:45:40,880 YEARS, WE WERE CREATED BECAUSE 3913 02:45:40,880 --> 02:45:41,800 OF DENTAL CARIES. 3914 02:45:41,800 --> 02:45:44,680 75 YEARS LATER WE STILL HAVE IT 3915 02:45:44,680 --> 02:45:46,720 AS A SOCIETAL THREAT, SYMBOLIC 3916 02:45:46,720 --> 02:45:49,920 OF A LARGER PROBLEM NIDCR SHOULD 3917 02:45:49,920 --> 02:45:51,680 BE AWARE OF AND PART OF THAT 3918 02:45:51,680 --> 02:45:59,680 CHANGE THAT IS TO COME. 3919 02:45:59,680 --> 02:46:01,000 WE IDENTIFY PROBLEMS THROUGH THE 3920 02:46:01,000 --> 02:46:01,600 REPORT. 3921 02:46:01,600 --> 02:46:03,920 WE HAVE A PLAN, A STRATEGIC PLAN 3922 02:46:03,920 --> 02:46:06,040 CAME OUT INDEPENDENTLY OF THE 3923 02:46:06,040 --> 02:46:07,520 REPORT BUT ABOUT THE SAME TIME. 3924 02:46:07,520 --> 02:46:10,200 I THINK IF WE CONNECT THOSE DOTS 3925 02:46:10,200 --> 02:46:14,080 AND WE REALLY ARE, BECAUSE OUR 3926 02:46:14,080 --> 02:46:15,520 LEADERS ARE ACCOUNTABLE, 3927 02:46:15,520 --> 02:46:19,120 EVALUATIONS OCCUR, AS MINE WILL 3928 02:46:19,120 --> 02:46:22,720 BE BY THE DIRECTOR OF NIH THAT 3929 02:46:22,720 --> 02:46:25,400 WE MOVE THE NEEDLE BECAUSE WE 3930 02:46:25,400 --> 02:46:27,120 HAVE ADDRESSED THE PRIORITIES 3931 02:46:27,120 --> 02:46:29,200 THAT WE COLLECTIVELY AS A 3932 02:46:29,200 --> 02:46:30,680 COMMUNITY DECIDED ON. 3933 02:46:30,680 --> 02:46:33,720 IF WE DID THAT I THINK 3934 02:46:33,720 --> 02:46:36,200 COLLECTING RESULTS, LOOKING AT 3935 02:46:36,200 --> 02:46:37,800 SYSTEMS APPROACHES, WAYS TO DO 3936 02:46:37,800 --> 02:46:39,640 THINGS BETTER, THERE WILL BE A 3937 02:46:39,640 --> 02:46:42,680 RESULT THAT WILL IMPROVE ORAL 3938 02:46:42,680 --> 02:46:43,760 HEALTH FOR ALL. 3939 02:46:43,760 --> 02:46:46,160 OH, HOW DID THAT HAPPEN? 3940 02:46:46,160 --> 02:46:48,040 SIGNIFIES THE WAY I WAS 3941 02:46:48,040 --> 02:46:49,360 THINKING, LOTS OF ACTIVITY, I 3942 02:46:49,360 --> 02:46:52,200 MUST THANK THOSE WHO INVITED US. 3943 02:46:52,200 --> 02:46:56,720 AND WHO EXTENDED SUCH WARMTH AND 3944 02:46:56,720 --> 02:46:58,000 HOSPITALITY MAKING EACH VISIT 3945 02:46:58,000 --> 02:46:58,320 SPECIAL. 3946 02:46:58,320 --> 02:47:02,160 FOR ME THE ONLY WAY I CAN HAVE A 3947 02:47:02,160 --> 02:47:04,240 FINGER ON THE PULSE IS SITTING 3948 02:47:04,240 --> 02:47:07,720 IN FRONT OF TRAINEES, DEANS, 3949 02:47:07,720 --> 02:47:08,720 HIRED ADMINISTRATORS, FEELING 3950 02:47:08,720 --> 02:47:10,600 CHANGE THAT IS OCCURRING RIGHT 3951 02:47:10,600 --> 02:47:11,080 NOW. 3952 02:47:11,080 --> 02:47:13,760 I BRING THAT DATA BACK TO OUR 3953 02:47:13,760 --> 02:47:16,280 PROGRAM AND WE CONSIDER IDEAS 3954 02:47:16,280 --> 02:47:17,920 AND ISSUES THAT ARISE, AND ACT 3955 02:47:17,920 --> 02:47:22,160 ON THEM AND YOU CAN SEE ON THE 3956 02:47:22,160 --> 02:47:22,880 FAR RIGHT STRENGTHENING 3957 02:47:22,880 --> 02:47:24,160 RELATIONSHIPS WITH OUR TAKE 3958 02:47:24,160 --> 02:47:25,480 HOLDERS IS STRONG RIGHT NOW. 3959 02:47:25,480 --> 02:47:28,120 IT'S VERY ACTIVE RIGHT NOW. 3960 02:47:28,120 --> 02:47:30,160 JENNIFER IS ALSO PARTICIPATING. 3961 02:47:30,160 --> 02:47:33,680 SO HAS RENEE IN DISPERSING NEWS 3962 02:47:33,680 --> 02:47:34,560 OR DISSEMINATING NEWS ON THE 3963 02:47:34,560 --> 02:47:36,160 REPORT AND ACTIVITIES. 3964 02:47:36,160 --> 02:47:42,720 I THANK THEM BOTH. 3965 02:47:42,720 --> 02:47:45,800 GREAT PARTNERS TO HAVE. 3966 02:47:45,800 --> 02:47:48,440 HERE ARE FUNDING OPPORTUNITIES, 3967 02:47:48,440 --> 02:47:58,920 FIRST BEING A RENEWAL OF THE 3968 02:48:00,760 --> 02:48:00,920 K12. 3969 02:48:00,920 --> 02:48:03,000 CLINICIAN SCIENTIST IN THE 3970 02:48:03,000 --> 02:48:03,960 MAKING CAN GET BALANCE AND 3971 02:48:03,960 --> 02:48:06,520 QUALITY OF LIFE AND CONSIDER A 3972 02:48:06,520 --> 02:48:07,160 Ph.D. ALONG WITH DENTAL 3973 02:48:07,160 --> 02:48:12,640 SPECIALTY OR JUST Ph.D. ALONE. 3974 02:48:12,640 --> 02:48:15,360 THAT'S AN OPPORTUNITY AS IS THE 3975 02:48:15,360 --> 02:48:16,600 SUPPLEMENT, VERY IMPORTANT FOR 3976 02:48:16,600 --> 02:48:19,920 US IN DENTAL SCHOOLS TO BE 3977 02:48:19,920 --> 02:48:22,240 THINKING OF WAYS TO BE 3978 02:48:22,240 --> 02:48:24,160 COMPETITIVE FOR LARGER FUNDS. 3979 02:48:24,160 --> 02:48:28,960 WE HAVE TWO RFAs OUT NOW THAT 3980 02:48:28,960 --> 02:48:30,480 CLEARLY MENTIONED HERE, THAT YOU 3981 02:48:30,480 --> 02:48:32,480 CAN LOOK UP. 3982 02:48:32,480 --> 02:48:34,960 AND BOTH ADDRESS IMPORTANT 3983 02:48:34,960 --> 02:48:37,040 INTERSECTION AREAS AND SCREENING 3984 02:48:37,040 --> 02:48:39,560 FACIAL DISORDERS. 3985 02:48:39,560 --> 02:48:42,160 ONE CONCEPT CLEARANCE WILL BE 3986 02:48:42,160 --> 02:48:45,720 PRESENTED BY DENA FISCHER, FROM 3987 02:48:45,720 --> 02:48:48,600 AN FDA ALERT FOCUSED ON 3988 02:48:48,600 --> 02:48:50,000 BUPRENORPHINE, INCLUDES THE 3989 02:48:50,000 --> 02:48:51,520 SPECTRUM OF OPIOIDS AND 3990 02:48:51,520 --> 02:48:54,240 PREEXISTING DRUG USE CONDITIONS 3991 02:48:54,240 --> 02:48:58,440 THAT COMPROMISE SALIVARY FLOW 3992 02:48:58,440 --> 02:48:59,720 AND MAKE PATIENTS FOR 3993 02:48:59,720 --> 02:49:00,160 SUSCEPTIBLE. 3994 02:49:00,160 --> 02:49:02,280 I WILL END WITH A QUICK 3995 02:49:02,280 --> 02:49:04,000 RUN-THROUGH WHAT THE WORKING 3996 02:49:04,000 --> 02:49:08,520 GROUPS ARE GOING TO ACCOMPLISH 3997 02:49:08,520 --> 02:49:10,920 FOR US, THE VOICE OF THE 3998 02:49:10,920 --> 02:49:12,200 EXTRAMURAL COMMUNITY. 3999 02:49:12,200 --> 02:49:13,800 YOUR THOUGHTS, YOUR IDEAS, AND 4000 02:49:13,800 --> 02:49:15,400 YOU'RE GOING TO MAKE A 4001 02:49:15,400 --> 02:49:16,360 COLLABORATION SO YOU'RE NOT JUST 4002 02:49:16,360 --> 02:49:17,680 WORKING ON YOUR OWN. 4003 02:49:17,680 --> 02:49:21,080 THERE WILL BE STAFF SUPPORT AND 4004 02:49:21,080 --> 02:49:21,960 INSIGHTS PROVIDED BY PROGRAM 4005 02:49:21,960 --> 02:49:25,440 STAFF AND SO THE FIRST ONE ON 4006 02:49:25,440 --> 02:49:27,640 DATA SCIENCE IS REALLY A 4007 02:49:27,640 --> 02:49:30,280 NO-BRAINER, WE HAVE THINK ABOUT 4008 02:49:30,280 --> 02:49:32,360 WAYS REALISTICALLY WE HAVE OPEN 4009 02:49:32,360 --> 02:49:35,080 UP OUR FIELD BY CONNECTING THE 4010 02:49:35,080 --> 02:49:35,440 DOTS. 4011 02:49:35,440 --> 02:49:38,680 OR FOR THE BENEFIT OF PATIENTS 4012 02:49:38,680 --> 02:49:40,360 AND OUR COMMUNITIES. 4013 02:49:40,360 --> 02:49:42,320 THE GAPS REALLY EXISTING RIGHT 4014 02:49:42,320 --> 02:49:45,160 NOW, WE DON'T HAVE THAT KIND OF 4015 02:49:45,160 --> 02:49:46,720 COALESCING THAT'S OCCURRING. 4016 02:49:46,720 --> 02:49:49,200 WE DON'T REALLY KNOW ALL THAT'S 4017 02:49:49,200 --> 02:49:49,560 AVAILABLE. 4018 02:49:49,560 --> 02:49:52,520 I EVEN INCLUDE THERE THE DIGITAL 4019 02:49:52,520 --> 02:49:54,000 TECHNOLOGY DATA THAT SOME 4020 02:49:54,000 --> 02:49:55,920 SCHOOLS INVESTED IN RIGHT NOW. 4021 02:49:55,920 --> 02:49:58,520 AND SOME WHO ARE REALLY ACTUALLY 4022 02:49:58,520 --> 02:50:02,160 LOOKING AT THE WISDOM INTERFACE 4023 02:50:02,160 --> 02:50:03,880 BETWEEN EPPIC AND AXIOM, THAT WE 4024 02:50:03,880 --> 02:50:07,680 DO HAVE THE OPPORTUNITY TO 4025 02:50:07,680 --> 02:50:09,080 CREATE THAT UNIFIED HEALTH 4026 02:50:09,080 --> 02:50:12,640 RECORD, WE'RE LOOKING AT THAT. 4027 02:50:12,640 --> 02:50:15,160 DIRECTED ALSO TO IDENTIFY HEALTH 4028 02:50:15,160 --> 02:50:16,120 DISPARITIES, AND INEQUALITY IS 4029 02:50:16,120 --> 02:50:17,920 DATA DRIVEN SO WE HAVE A MEANS 4030 02:50:17,920 --> 02:50:20,880 BY WHICH WE CAN OVERCOME IT FOR 4031 02:50:20,880 --> 02:50:21,480 US. 4032 02:50:21,480 --> 02:50:22,400 SO WE DON'T PRODUCE 20 YEARS 4033 02:50:22,400 --> 02:50:27,920 FROM NOW THE SAME DATA THAT 4034 02:50:27,920 --> 02:50:28,680 WE'RE LOOKING AT TODAY. 4035 02:50:28,680 --> 02:50:30,440 THIS IS WHAT THE WORKING GROUP 4036 02:50:30,440 --> 02:50:31,720 IS CHARGED TO DO. 4037 02:50:31,720 --> 02:50:33,840 IN CLOSED SESSION WE'LL BE 4038 02:50:33,840 --> 02:50:35,760 TALKING MUCH MORE IN DEPTH AT 4039 02:50:35,760 --> 02:50:37,720 HOW THIS CAN UNFOLD FOR US OVER 4040 02:50:37,720 --> 02:50:41,240 THE YEAR. 4041 02:50:41,240 --> 02:50:42,480 WE'VE IDENTIFIED THOUGHT 4042 02:50:42,480 --> 02:50:43,280 LEADERS, ANYONE LISTENING TODAY 4043 02:50:43,280 --> 02:50:45,400 THAT FEELS THIS IS YOUR AREA OF 4044 02:50:45,400 --> 02:50:46,360 PASSION AND INTEREST, THE DOOR 4045 02:50:46,360 --> 02:50:51,240 IS OPEN FOR YOU TO WRITE TO LYNN 4046 02:50:51,240 --> 02:50:55,960 KING AND, OR AXEL, EITHER ONE, 4047 02:50:55,960 --> 02:50:57,680 AND LET THEM KNOW OF THE 4048 02:50:57,680 --> 02:50:58,880 COMMITMENT. 4049 02:50:58,880 --> 02:51:00,840 IT WILL BE VIRTUALLY MOSTLY 4050 02:51:00,840 --> 02:51:02,200 UNLESS AN ON-SITE VISIT IS 4051 02:51:02,200 --> 02:51:02,600 POSSIBLE. 4052 02:51:02,600 --> 02:51:03,960 THESE ARE THE AREAS. 4053 02:51:03,960 --> 02:51:09,520 YOU CAN SEE A COUPLE OF THEM. 4054 02:51:09,520 --> 02:51:12,240 DANA GRAVES PICKED UP THIS 4055 02:51:12,240 --> 02:51:13,800 CAUSE, SOMETHING DEAR TO HIS 4056 02:51:13,800 --> 02:51:14,680 PROFESSIONAL INTEREST AND 4057 02:51:14,680 --> 02:51:15,000 PASSION. 4058 02:51:15,000 --> 02:51:16,840 TO TAKE UP THE CHARGE OF LOOKING 4059 02:51:16,840 --> 02:51:20,240 WITH A NEW SET OF LENSES YOU A 4060 02:51:20,240 --> 02:51:25,760 TO HOW BEST TO TRAIN SCIENTISTS 4061 02:51:25,760 --> 02:51:29,560 FOR THE FUTURE. 4062 02:51:29,560 --> 02:51:31,560 CLINICIAN SCIENTISTS WOULD HAVE 4063 02:51:31,560 --> 02:51:38,000 MAXIMUM SKILL SET TO BRIDGE THE 4064 02:51:38,000 --> 02:51:38,200 GAP. 4065 02:51:38,200 --> 02:51:47,080 YOU CAN SEE THERE ARE DETRACTORS 4066 02:51:47,080 --> 02:51:49,800 AND CHALLENGERS, IT'S DIFFICULT 4067 02:51:49,800 --> 02:51:51,240 WHEN SCIENCE AND TECHNOLOGY IS 4068 02:51:51,240 --> 02:51:52,680 MOVING SO FAST. 4069 02:51:52,680 --> 02:51:54,800 WE'VE GOT VERY COMMITTED THOUGHT 4070 02:51:54,800 --> 02:51:56,840 LEADERS IN THE FIELD. 4071 02:51:56,840 --> 02:51:59,200 CURRENT PROGRAM DIRECTORS, 4072 02:51:59,200 --> 02:52:01,840 TRAINING PROGRAM DIRECTORS, K 4073 02:52:01,840 --> 02:52:03,840 AND F MENTORS, AND MENTEES, WILL 4074 02:52:03,840 --> 02:52:05,240 BE AT THE TABLE. 4075 02:52:05,240 --> 02:52:15,800 AND I THINK THE IDEA THAT 55% OF 4076 02:52:17,440 --> 02:52:19,800 NIDCR'S BUDGET IS OUTSIDE DENTAL 4077 02:52:19,800 --> 02:52:23,880 SCHOOLS, IT WILL TAKE TIME, 4078 02:52:23,880 --> 02:52:24,240 SCIENCE MATTERS. 4079 02:52:24,240 --> 02:52:26,160 WHAT IS IMPORTANT, 55% OF 4080 02:52:26,160 --> 02:52:31,600 FUNDEES THAT GET MONEY FROM 4081 02:52:31,600 --> 02:52:32,840 TRAINEES, POSTDOCS, GRADUATE 4082 02:52:32,840 --> 02:52:37,080 STUDENTS, WE WANT TO MAKE SURE 4083 02:52:37,080 --> 02:52:38,080 THEY ARE EMBRACED THAT OUR 4084 02:52:38,080 --> 02:52:39,480 COMMUNITY MOVES THEM SO THEY 4085 02:52:39,480 --> 02:52:41,480 STAY TRUE TO WHAT THEIR Ph.D. 4086 02:52:41,480 --> 02:52:43,800 PROJECT WAS OR INTEREST AREA IS 4087 02:52:43,800 --> 02:52:51,440 AND THAT'S HOW WE CAN DIVERSE IF 4088 02:52:51,440 --> 02:52:53,480 I-- DIVERSIFY THE PIPELINE. 4089 02:52:53,480 --> 02:52:56,120 ALL ASPECTS TRAINING AND CAREER 4090 02:52:56,120 --> 02:52:58,760 DEVELOPMENT LOOK AT DATA THAT 4091 02:52:58,760 --> 02:53:00,520 WOULD BACK IT UP, EACH STEP OF 4092 02:53:00,520 --> 02:53:03,240 THE WAY SO WE MAKE A NEW FUTURE. 4093 02:53:03,240 --> 02:53:05,240 WHAT'S EXCITING IS THAT AS WE 4094 02:53:05,240 --> 02:53:09,280 TALKED ABOUT OUR PLANS FOR 4095 02:53:09,280 --> 02:53:11,000 CELEBRATING THE DIAMOND JUBILEE 4096 02:53:11,000 --> 02:53:15,800 YEAR WHAT CAME UP AS THE 4097 02:53:15,800 --> 02:53:20,880 FLAGSHIP EVENT, SIGNIFIES THE 4098 02:53:20,880 --> 02:53:25,240 FUTURE, THE TRAINEES ACROSS OUR 4099 02:53:25,240 --> 02:53:27,320 PROGRAM AND MENTORS ON CAMPUS TO 4100 02:53:27,320 --> 02:53:28,680 SHOWCASE RESEARCH WITH 4101 02:53:28,680 --> 02:53:32,080 INTRAMURAL TRAINEES AS WELL AND 4102 02:53:32,080 --> 02:53:33,440 MAKE THAT A SPECIAL CELEBRATION 4103 02:53:33,440 --> 02:53:35,440 OF WHO WE ARE AND WHAT WE'RE 4104 02:53:35,440 --> 02:53:38,840 COMMITTED TO FOR THE FUTURE. 4105 02:53:38,840 --> 02:53:41,000 SO, NOTHING COULD BE POSSIBLE 4106 02:53:41,000 --> 02:53:45,720 WITHOUT THE AMAZING GROUP OF 4107 02:53:45,720 --> 02:53:48,360 STAFF, DEDICATED, TALENTED, 4108 02:53:48,360 --> 02:53:49,200 COMMITTED, CARING, 4109 02:53:49,200 --> 02:53:51,360 COMPASSIONATE, MAKES EVERY DAY 4110 02:53:51,360 --> 02:53:53,160 TRULY AN HONOR AND PRIVILEGE. 4111 02:53:53,160 --> 02:53:55,440 DOESN'T MATTER IF YOU'RE VIRTUAL 4112 02:53:55,440 --> 02:53:58,880 OR ON-SITE, IT'S A THRILL. 4113 02:53:58,880 --> 02:54:00,800 I ECHO JENNIFER'S SENTIMENTS AND 4114 02:54:00,800 --> 02:54:01,680 LEADERSHIP TEAM. 4115 02:54:01,680 --> 02:54:03,680 THANK YOU FOR LISTENING. 4116 02:54:03,680 --> 02:54:05,320 STAY CONNECTED, OPEN TO 4117 02:54:05,320 --> 02:54:06,200 QUESTIONS AND COMMENTS YOU MIGHT 4118 02:54:06,200 --> 02:54:06,440 HAVE. 4119 02:54:06,440 --> 02:54:09,080 I PICKED THIS UP FROM GOOGLE, 4120 02:54:09,080 --> 02:54:10,800 IT'S GOT A FACE ON THE RIGHT 4121 02:54:10,800 --> 02:54:13,240 SIDE OF THE QUESTION MARK, I 4122 02:54:13,240 --> 02:54:14,800 THOUGHT THAT WAS APT. 4123 02:54:14,800 --> 02:54:17,240 ANY QUESTIONS? 4124 02:54:17,240 --> 02:54:20,400 4125 02:54:20,400 --> 02:54:28,760 BEFORE I INTRODUCE SUSAN 4126 02:54:28,760 --> 02:54:29,360 GREGURICK. 4127 02:54:29,360 --> 02:54:30,600 SURELY THERE'S SOME. 4128 02:54:30,600 --> 02:54:33,800 AXEL PUTS OUT A CALL IF YOU'RE 4129 02:54:33,800 --> 02:54:34,680 INTERESTED IN PARTICIPATING, 4130 02:54:34,680 --> 02:54:36,400 DATA SCIENCE WORK GROUP LET HIM 4131 02:54:36,400 --> 02:54:37,040 KNOW. 4132 02:54:37,040 --> 02:54:41,320 HE'S PUT DOWN HIS E-MAIL 4133 02:54:41,320 --> 02:54:42,000 ADDRESS. 4134 02:54:42,000 --> 02:54:49,520 THANK YOU, AXEL. 4135 02:54:49,520 --> 02:54:51,080 4136 02:54:51,080 --> 02:54:52,160 DOES ANYONE HAVE QUESTIONS? 4137 02:54:52,160 --> 02:54:55,400 I'D BE HAPPY TO ANSWER. 4138 02:54:55,400 --> 02:55:00,040 4139 02:55:00,040 --> 02:55:00,360 NOW? 4140 02:55:00,360 --> 02:55:01,840 HOW'S THAT FOR STIMULATING 4141 02:55:01,840 --> 02:55:02,440 DISCUSSION. 4142 02:55:02,440 --> 02:55:04,680 WELL, WITH THAT I WILL JUST WANT 4143 02:55:04,680 --> 02:55:09,000 TO SAY IS IT TIME FOR LUNCH OR 4144 02:55:09,000 --> 02:55:13,400 MOVE TO SUSAN? 4145 02:55:13,400 --> 02:55:14,360 >> WE MOVE TO SUSAN. 4146 02:55:14,360 --> 02:55:17,320 >> A THRILL TO INTRODUCE YOU. 4147 02:55:17,320 --> 02:55:19,800 SUSAN HAS INTERACTED WITH OUR 4148 02:55:19,800 --> 02:55:20,800 EXECUTIVE STAFF TO GIVE A SENSE 4149 02:55:20,800 --> 02:55:23,440 FOR THAT FIELD OF DATA SCIENCE, 4150 02:55:23,440 --> 02:55:24,840 WHAT DOES IT INVOLVE, WHAT DOES 4151 02:55:24,840 --> 02:55:28,040 IT INCLUDE AND WHAT DOES IT NOT 4152 02:55:28,040 --> 02:55:28,800 INCLUDE? 4153 02:55:28,800 --> 02:55:31,000 LOTS OF TERMINOLOGY, LOTS OF 4154 02:55:31,000 --> 02:55:32,040 HUGE AMOUNT OF TECHNOLOGY, 4155 02:55:32,040 --> 02:55:33,840 SOMETIMES DIFFICULT TO WRAP YOUR 4156 02:55:33,840 --> 02:55:35,600 HEAD AROUND. 4157 02:55:35,600 --> 02:55:36,840 SO WE THOUGHT WHY NOT HAVE SUSAN 4158 02:55:36,840 --> 02:55:38,200 WHO IS VERY GENEROUS WITH HER 4159 02:55:38,200 --> 02:55:40,200 TIME AND HER KNOWLEDGE TO SHARE 4160 02:55:40,200 --> 02:55:41,360 THIS WITH US. 4161 02:55:41,360 --> 02:55:43,440 SUSAN, I THANK YOU FOR YOUR 4162 02:55:43,440 --> 02:55:43,760 COMMITMENT. 4163 02:55:43,760 --> 02:55:45,720 ALL THAT YOU DO AT NIH AND ALL 4164 02:55:45,720 --> 02:55:47,600 THAT YOU'RE DOING TO MAKE DATA 4165 02:55:47,600 --> 02:55:49,480 SCIENCE REALITY FOR OUR 4166 02:55:49,480 --> 02:55:54,520 INSTITUTES AND FOR NIH IN 4167 02:55:54,520 --> 02:55:55,720 GENERAL. 4168 02:55:55,720 --> 02:55:56,800 THANK YOU. 4169 02:55:56,800 --> 02:55:59,520 >> THANK YOU SO MUCH, DR. 4170 02:55:59,520 --> 02:55:59,760 D'SOUZA. 4171 02:55:59,760 --> 02:56:01,960 CAN YOU HEAR ME OKAY? 4172 02:56:01,960 --> 02:56:03,240 >> YES. 4173 02:56:03,240 --> 02:56:03,600 >> AWESOME. 4174 02:56:03,600 --> 02:56:05,000 SUCH A PLEASURE TO BE HERE AND I 4175 02:56:05,000 --> 02:56:06,920 KNOW THAT I MIGHT BE CUTTING 4176 02:56:06,920 --> 02:56:07,640 INTO YOUR LUNCH TIME. 4177 02:56:07,640 --> 02:56:09,400 CAN YOU LET ME KNOW IF YOU'D 4178 02:56:09,400 --> 02:56:12,000 LIKE ME TO SHORTEN SO THAT YOU 4179 02:56:12,000 --> 02:56:13,960 WILL HAVE ADEQUATE TIME FOR 4180 02:56:13,960 --> 02:56:14,560 LUNCH? 4181 02:56:14,560 --> 02:56:16,280 >> NO, I DON'T THINK SO. 4182 02:56:16,280 --> 02:56:18,440 I THINK WE CAN GRAB WHATEVER WE 4183 02:56:18,440 --> 02:56:21,080 HAVE AROUND US AND NOT 4184 02:56:21,080 --> 02:56:22,720 COMPROMISE ON YOUR PRESENTATION 4185 02:56:22,720 --> 02:56:24,040 AT ALL. 4186 02:56:24,040 --> 02:56:24,560 PLEASE. 4187 02:56:24,560 --> 02:56:29,520 THERE'S PEOPLE IN DIFFERENT TIME 4188 02:56:29,520 --> 02:56:32,160 ZONES, SOME COULD BE EATING 4189 02:56:32,160 --> 02:56:33,440 BREAKFAST, WHO KNOWS. 4190 02:56:33,440 --> 02:56:35,760 >> IT'S A NEW WORLD VIRTUALLY, 4191 02:56:35,760 --> 02:56:38,280 DOING OUR WORK BY ZOOM FOR THE 4192 02:56:38,280 --> 02:56:40,240 MOST PART, ALL OUR COUNCIL 4193 02:56:40,240 --> 02:56:40,800 MEETINGS. 4194 02:56:40,800 --> 02:56:43,560 THANK YOU AGAIN FOR INVITING ME 4195 02:56:43,560 --> 02:56:44,840 TO THE COUNCIL MEETING. 4196 02:56:44,840 --> 02:56:47,280 I'M JUST THRILLED TO BE ABLE TO 4197 02:56:47,280 --> 02:56:50,080 TELL YOU ABOUT WHAT WE'RE DOING 4198 02:56:50,080 --> 02:56:53,040 AT NIH TO CONNECT OUR DATA, 4199 02:56:53,040 --> 02:56:55,480 ENHANCE SOFTWARE, AND TO CREATE 4200 02:56:55,480 --> 02:57:01,160 A DIGITAL DATA HEALTH ECOSYSTEM. 4201 02:57:01,160 --> 02:57:03,160 NEXT SLIDE IS A HIGHLIGHT OF THE 4202 02:57:03,160 --> 02:57:04,560 NIH STRATEGIC PLAN FOR DATA 4203 02:57:04,560 --> 02:57:04,920 SCIENCE. 4204 02:57:04,920 --> 02:57:10,400 THIS IS THE NORTH STAR FROM MY 4205 02:57:10,400 --> 02:57:10,800 OFFICE. 4206 02:57:10,800 --> 02:57:13,400 REALLY HELPS ARTICULATE OUR 4207 02:57:13,400 --> 02:57:14,600 GOALS AND DATA SCIENCE 4208 02:57:14,600 --> 02:57:15,880 STRATEGICAL FOR THE NIH. 4209 02:57:15,880 --> 02:57:19,840 YOU CAN SEE THEM LISTED HERE 4210 02:57:19,840 --> 02:57:20,760 SUPPORTING COMMON 4211 02:57:20,760 --> 02:57:21,440 INFRASTRUCTURE, LEVERAGING 4212 02:57:21,440 --> 02:57:23,280 INDUSTRY RESOURCES AND ADOPTING 4213 02:57:23,280 --> 02:57:26,240 AND ADAPTING TECHNOLOGIES TO OUR 4214 02:57:26,240 --> 02:57:27,040 FIELDS. 4215 02:57:27,040 --> 02:57:28,640 ENHANCING BIOMEDICAL DATA 4216 02:57:28,640 --> 02:57:30,040 SCIENCE RESEARCH WORKFORCE AS 4217 02:57:30,040 --> 02:57:30,920 DR. D'SOUZA SAID. 4218 02:57:30,920 --> 02:57:32,000 THIS IS AN IMPORTANT COMPONENT 4219 02:57:32,000 --> 02:57:35,560 OF WHAT WE DO AT NIH AND IN DATA 4220 02:57:35,560 --> 02:57:37,960 SCIENCE, ALSO AN IMPORTANT 4221 02:57:37,960 --> 02:57:38,240 COMPONENT. 4222 02:57:38,240 --> 02:57:49,000 ENHANCING OUR ABILITY TO SHARE 4223 02:57:49,000 --> 02:57:49,560 DATA, ACCESS DATA, CREATE 4224 02:57:49,560 --> 02:57:51,040 INTEROPERABILITY IN ACCORDANCE 4225 02:57:51,040 --> 02:57:52,960 WITH LAWS AND REQUIREMENTS. 4226 02:57:52,960 --> 02:57:54,120 IMPORTANTLY, WITH COMMUNITY 4227 02:57:54,120 --> 02:57:56,000 INPUT AND YOUR INPUT DEVELOPING 4228 02:57:56,000 --> 02:58:00,920 AND PROMOTING AND REFINING 4229 02:58:00,920 --> 02:58:02,720 STANDARDS, STANDARDIZED 4230 02:58:02,720 --> 02:58:04,680 VOCABULARIES, ELEMENTS, MODELS, 4231 02:58:04,680 --> 02:58:09,280 ONTOLOGIES, CREATING ABILITY TO 4232 02:58:09,280 --> 02:58:10,680 ENABLE FAIR DATA. 4233 02:58:10,680 --> 02:58:14,600 THESE ARE SOME HIGHLIGHTS FROM 4234 02:58:14,600 --> 02:58:16,040 THE STRATEGIC PLAN. 4235 02:58:16,040 --> 02:58:18,800 NEXT SLIDE TELLS MORE ABOUT MY 4236 02:58:18,800 --> 02:58:19,240 OFFICE. 4237 02:58:19,240 --> 02:58:22,040 WE'RE IN THE OFFICE OF THE 4238 02:58:22,040 --> 02:58:23,720 DIRECTOR IN DPCPSI, KNOWN MOSTLY 4239 02:58:23,720 --> 02:58:26,560 FOR THE COMMON FUND BUT ACROSS 4240 02:58:26,560 --> 02:58:28,400 DPCPSI OUR OFFICES PLAY 4241 02:58:28,400 --> 02:58:29,520 LEADERSHIP ROLES IN COORDINATING 4242 02:58:29,520 --> 02:58:31,800 AND FOR ME ON THE STRATEGIC PLAN 4243 02:58:31,800 --> 02:58:37,360 FOR DATA SCIENCE. 4244 02:58:37,360 --> 02:58:41,880 WE HELP DEVELOP AND IMPLEMENT 4245 02:58:41,880 --> 02:58:43,960 VISION FOR ECOSYSTEM, PROMOTE 4246 02:58:43,960 --> 02:58:46,920 DATA SCIENCE THROUGH WORKFORCE 4247 02:58:46,920 --> 02:58:47,840 DEVELOPMENT. 4248 02:58:47,840 --> 02:58:50,120 AND BUILDING STRATEGIC 4249 02:58:50,120 --> 02:58:51,400 PARTNERSHIPS ACROSS NIH WITH 4250 02:58:51,400 --> 02:58:53,400 OTHER FEDERAL AGENCIES SUCH AS 4251 02:58:53,400 --> 02:58:57,560 NSF AND DEPARTMENT OF ENERGY TO 4252 02:58:57,560 --> 02:58:58,760 HELP DEVELOP AND DISSEMINATE 4253 02:58:58,760 --> 02:59:02,680 TECHNOLOGIES AND METHODS. 4254 02:59:02,680 --> 02:59:04,880 NEXT IS THE SAME BUT ILLUSTRATED 4255 02:59:04,880 --> 02:59:07,360 IN TERMS OF ACTIONABLE ITEMS 4256 02:59:07,360 --> 02:59:08,480 THAT WE'RE WORKING ON AT NIH. 4257 02:59:08,480 --> 02:59:14,040 I CAN'T ITEM YOU -- TELL YOU 4258 02:59:14,040 --> 02:59:15,360 ABOUT ALL, I'LL HIGHLIGHT A FEW 4259 02:59:15,360 --> 02:59:15,760 TODAY. 4260 02:59:15,760 --> 02:59:19,400 IF YOU'RE INTERESTED OUR WEBSITE 4261 02:59:19,400 --> 02:59:22,080 LISTS EVERYTHING WE'RE DOING TO 4262 02:59:22,080 --> 02:59:25,080 INSTANTIATE AND IMPLEMENT 4263 02:59:25,080 --> 02:59:26,080 STRATEGIC PLAN. 4264 02:59:26,080 --> 02:59:29,120 NEXT SLIDE IS A WAY TO CAPTURE 4265 02:59:29,120 --> 02:59:31,440 THE FACT THAT THIS IS REALLY AN 4266 02:59:31,440 --> 02:59:33,880 ALL OF NIH ACTIVITY. 4267 02:59:33,880 --> 02:59:36,600 WE WORK WITH OVER 23 INSTITUTES 4268 02:59:36,600 --> 02:59:38,040 AND CENTERS AND OFFICES, MORE 4269 02:59:38,040 --> 02:59:40,680 THAN 190 NIH STAFF CONTRIBUTING 4270 02:59:40,680 --> 02:59:44,040 ON WORKING GROUPS ON 4271 02:59:44,040 --> 02:59:45,560 IMPLEMENTING FUNDING 4272 02:59:45,560 --> 02:59:47,080 ANNOUNCEMENTS, SUPPLEMENTAL 4273 02:59:47,080 --> 02:59:47,600 ANNOUNCEMENTS, CONTRACTS, 4274 02:59:47,600 --> 02:59:49,720 OTAs, OTHER ACTIVITIES SUCH AS 4275 02:59:49,720 --> 02:59:50,840 TRAINING ACTIVITIES TO CATALYZE 4276 02:59:50,840 --> 02:59:51,600 DATA SCIENCE ACROSS NIH. 4277 02:59:51,600 --> 02:59:52,800 THIS IS THE STORY I'M TELLING 4278 02:59:52,800 --> 02:59:55,760 YOU, THE STORY OF ALL THE WORK 4279 02:59:55,760 --> 02:59:58,600 WE DO TOGETHER. 4280 02:59:58,600 --> 02:59:59,880 NEXT SLIDE. 4281 02:59:59,880 --> 03:00:01,760 JUST AN OVERVIEW OF WHAT I WILL 4282 03:00:01,760 --> 03:00:03,640 TALK TODAY, AGAIN I CAN'T TALK 4283 03:00:03,640 --> 03:00:05,400 TO EVERYTHING BUT I PICKED OUT A 4284 03:00:05,400 --> 03:00:07,480 FEW AREAS THAT I THOUGHT WOULD 4285 03:00:07,480 --> 03:00:09,520 BE MOST IMPORTANT AND IMPACTFUL 4286 03:00:09,520 --> 03:00:11,600 FOR THIS COMMUNITY. 4287 03:00:11,600 --> 03:00:12,520 I CAN ANSWER QUESTIONS ON 4288 03:00:12,520 --> 03:00:17,520 ANYTHING THAT MAY BE OF 4289 03:00:17,520 --> 03:00:21,360 INTEREST. 4290 03:00:21,360 --> 03:00:25,280 BY SHARING MIKE LAUER'S SLIDES 4291 03:00:25,280 --> 03:00:28,440 AND HOW WE'RE SUPPORTING THE 4292 03:00:28,440 --> 03:00:29,680 MANAGEMENT SHARING POLICY TO 4293 03:00:29,680 --> 03:00:33,680 FAIR DATA AND TRUST 4294 03:00:33,680 --> 03:00:39,240 REPOSITORIES, PARTNERSHIPS WITH 4295 03:00:39,240 --> 03:00:40,720 CLOUD SERVICE PROVIDERS, WITH 4296 03:00:40,720 --> 03:00:43,320 NSF AND OTHER PROGRAMS. 4297 03:00:43,320 --> 03:00:45,480 I WANT TO HIGHLIGHT RESOURCES, 4298 03:00:45,480 --> 03:00:46,080 INTERSECTION WITH DENTAL 4299 03:00:46,080 --> 03:00:49,480 RESOURCES AND CLOSE ON THE DATA 4300 03:00:49,480 --> 03:00:53,720 SCHOLARS IF THERE'S TIME. 4301 03:00:53,720 --> 03:00:55,440 NEXT SLIDE. 4302 03:00:55,440 --> 03:00:56,440 IT'S SOMETHING I'M FAIRLY 4303 03:00:56,440 --> 03:00:59,600 CERTAIN YOU'VE HEARD ABOUT AND 4304 03:00:59,600 --> 03:01:01,680 THINKING ABOUT, ACROSS NIH WE'RE 4305 03:01:01,680 --> 03:01:02,920 THINKING ABOUT THIS. 4306 03:01:02,920 --> 03:01:05,840 IT'S FINAL NIH POLICY FOR DATA 4307 03:01:05,840 --> 03:01:06,920 MANAGEMENT SHARING. 4308 03:01:06,920 --> 03:01:10,400 THIS POLICY WILL GO INTO EFFECT 4309 03:01:10,400 --> 03:01:12,520 ON JANUARY 25 OF 2023. 4310 03:01:12,520 --> 03:01:14,160 IT WILL REQUIRE RESEARCHERS TO 4311 03:01:14,160 --> 03:01:17,120 PLAN FOR HOW YOU WILL MANAGE AND 4312 03:01:17,120 --> 03:01:17,880 SHARE YOUR SCIENTIFIC DATA 4313 03:01:17,880 --> 03:01:20,080 THROUGH THE SUBMISSION OF YOUR 4314 03:01:20,080 --> 03:01:22,520 DATA AND MANAGEMENT SHARING 4315 03:01:22,520 --> 03:01:24,240 PLAN. 4316 03:01:24,240 --> 03:01:26,200 AT THE TIME OF APPLICATION YOUR 4317 03:01:26,200 --> 03:01:27,440 PLAN WILL OUTLINE HOW YOU PLAN 4318 03:01:27,440 --> 03:01:30,160 TO MANAGE AN SHARE YOUR DATA 4319 03:01:30,160 --> 03:01:31,800 WITH ACCOMPANYING METADATA, 4320 03:01:31,800 --> 03:01:36,000 TAKING INTO ACCOUNT POTENTIAL 4321 03:01:36,000 --> 03:01:38,600 RESTRICTIONS ON SHARING DATA. 4322 03:01:38,600 --> 03:01:40,240 IT'S PART OF YOUR BUDGET 4323 03:01:40,240 --> 03:01:45,240 JUSTIFICATION SECTION FOR YOUR 4324 03:01:45,240 --> 03:01:46,120 EXTRAMURAL AWARDS. 4325 03:01:46,120 --> 03:01:49,080 IF YOU CLICK YOU'LL SEE SOME OF 4326 03:01:49,080 --> 03:01:57,440 THE CAVEATS FOR THIS PLAN. 4327 03:01:57,440 --> 03:02:00,720 THIS WILL APPLY TO ALL RESEARCH, 4328 03:02:00,720 --> 03:02:02,000 FUNDED THROUGH GRANT, CONTRACT, 4329 03:02:02,000 --> 03:02:05,160 OTA, OR WHETHER YOU'RE AN 4330 03:02:05,160 --> 03:02:06,520 INTRAMURAL RESEARCHER. 4331 03:02:06,520 --> 03:02:07,600 ACTIVITIES THAT ARE EXCLUDED OF 4332 03:02:07,600 --> 03:02:09,800 COURSE ARE THOSE THAT DO NOT 4333 03:02:09,800 --> 03:02:12,400 GENERATE SCIENTIFIC DATA 4334 03:02:12,400 --> 03:02:15,200 INCLUDING OUR TRAINING GRANTS, 4335 03:02:15,200 --> 03:02:17,640 DEVELOPMENT AWARDS, 4336 03:02:17,640 --> 03:02:19,240 NON-SCIENTIFIC ACTIVITIES. 4337 03:02:19,240 --> 03:02:23,160 NEXT SLIDE IS A FEW NOTES FROM 4338 03:02:23,160 --> 03:02:26,000 DR. LAUER, WHAT WE HOPE TO DO IS 4339 03:02:26,000 --> 03:02:27,640 IMPART WITH YOU THE CONCEPT ALL 4340 03:02:27,640 --> 03:02:30,000 THE DATA SHOULD BE MANAGED IN 4341 03:02:30,000 --> 03:02:32,120 OUR RESEARCH ENTERPRISE. 4342 03:02:32,120 --> 03:02:32,840 THAT DOESN'T NECESSARILY MEAN 4343 03:02:32,840 --> 03:02:36,920 ALL DATA WILL BE SHARED BUT 4344 03:02:36,920 --> 03:02:38,360 SHOULD ALL BE MANAGED, 4345 03:02:38,360 --> 03:02:40,400 ARTICULATING WHICH WAYS ARE YOU 4346 03:02:40,400 --> 03:02:41,280 GENERATING SCIENTIFIC DATA, HOW 4347 03:02:41,280 --> 03:02:44,000 WOULD YOU PLAN ON SHARING THAT 4348 03:02:44,000 --> 03:02:44,360 DATA? 4349 03:02:44,360 --> 03:02:45,880 WHAT WE DON'T ANTICIPATE YOU 4350 03:02:45,880 --> 03:02:48,640 SHARING IS YOUR LABORATORY 4351 03:02:48,640 --> 03:02:50,960 NOTEBOOKS, PRELIMINARY ANALYSIS, 4352 03:02:50,960 --> 03:02:52,680 CASE REPORTS, PHYSICAL OBJECTS. 4353 03:02:52,680 --> 03:02:53,880 WE HOPE YOU'LL SHARE YOUR DATA 4354 03:02:53,880 --> 03:02:56,080 NO LATER THAN THE TIME OF 4355 03:02:56,080 --> 03:02:57,560 PUBLICATION OF THE SCIENTIFIC 4356 03:02:57,560 --> 03:03:02,320 FINDING OR AT THE END OF YOUR 4357 03:03:02,320 --> 03:03:02,520 AWARD. 4358 03:03:02,520 --> 03:03:04,520 THE NEXT SLIDE ARE SOME 4359 03:03:04,520 --> 03:03:06,320 CONSIDERATIONS FOR ELEMENTS OF 4360 03:03:06,320 --> 03:03:07,360 DATA MANAGEMENT SHARING PLAN 4361 03:03:07,360 --> 03:03:09,120 INCLUDING TYPE OF DATA THAT 4362 03:03:09,120 --> 03:03:12,360 YOU'LL BE SHARING AND 4363 03:03:12,360 --> 03:03:13,240 PRESERVING, RELATED TOOLS OR 4364 03:03:13,240 --> 03:03:18,400 SOFTWARE ANALYSIS CODE NEEDED TO 4365 03:03:18,400 --> 03:03:19,800 ACCESS DATA, STANDARDS THAT 4366 03:03:19,800 --> 03:03:20,560 APPLY. 4367 03:03:20,560 --> 03:03:23,440 I WANT TO HIGHLIGHT 4368 03:03:23,440 --> 03:03:24,200 SCIENTIFICALLY METADATA THAT 4369 03:03:24,200 --> 03:03:26,480 CREATES BETTER WAY TO FIND AND 4370 03:03:26,480 --> 03:03:32,720 USE DATA OF YOUR RESEARCH. 4371 03:03:32,720 --> 03:03:34,360 FACTORS THAT AFFECT DATA ACCESS 4372 03:03:34,360 --> 03:03:36,680 AND WHICH DATA WOULD FALL UNDER 4373 03:03:36,680 --> 03:03:37,760 CONTROL OF ACCESS REQUIREMENT 4374 03:03:37,760 --> 03:03:39,720 SUCH AS FOR EXAMPLE GENOMICS 4375 03:03:39,720 --> 03:03:44,320 DATA OR IMAGING DATA THAT 4376 03:03:44,320 --> 03:03:45,320 CONTAIN IDENTIFIABLE ELEMENTS. 4377 03:03:45,320 --> 03:03:48,680 YOU'LL WANT TO TALK ABOUT THE 4378 03:03:48,680 --> 03:03:49,520 PRESERVATION OF DATA, REPOSITORY 4379 03:03:49,520 --> 03:03:51,360 THAT YOU'RE GOING TO BE USING TO 4380 03:03:51,360 --> 03:03:54,520 SHARE THE DATA. 4381 03:03:54,520 --> 03:03:56,120 AND OVERALL DATA MANAGEMENT PLAN 4382 03:03:56,120 --> 03:04:00,400 AND WHO WILL MANAGE THE DATA. 4383 03:04:00,400 --> 03:04:02,680 NEXT SLIDE IS JUST A NOTE ON THE 4384 03:04:02,680 --> 03:04:04,560 ALLOWABLE COST THAT YOU CAN 4385 03:04:04,560 --> 03:04:06,880 REQUEST IN YOUR BUDGET TO CURATE 4386 03:04:06,880 --> 03:04:09,160 THE DATA, DEVELOP SUPPORTING 4387 03:04:09,160 --> 03:04:10,680 DOCUMENTATION, PRESERVING AND 4388 03:04:10,680 --> 03:04:15,920 SHAKER DATA THROUGH REPOSITORIES 4389 03:04:15,920 --> 03:04:18,440 IS ANOTHER ALLOWABLE COST. 4390 03:04:18,440 --> 03:04:23,400 NOT INCLUDED WOULD BE 4391 03:04:23,400 --> 03:04:24,040 INFRASTRUCTURE COST. 4392 03:04:24,040 --> 03:04:33,600 I WANT TO POINT YOU TO A NEW 4393 03:04:33,600 --> 03:04:35,280 WEBSITE, SHARING.NIH.GOV TELLING 4394 03:04:35,280 --> 03:04:37,680 YOU APPROACHES, HOW TO SELECT A 4395 03:04:37,680 --> 03:04:40,680 REPOSITORY AND THEN A NUMBER OF 4396 03:04:40,680 --> 03:04:42,560 NIH AFFILIATED REPOSITORIES THAT 4397 03:04:42,560 --> 03:04:43,800 DO SUPPORT DATA SHARING. 4398 03:04:43,800 --> 03:04:45,760 THIS IS JUST A QUICK HIGHLIGHT 4399 03:04:45,760 --> 03:04:47,320 AND OVERVIEW OF A MUCH LONGER 4400 03:04:47,320 --> 03:04:49,960 PRESENTATION ON THE DATA 4401 03:04:49,960 --> 03:04:54,240 MANAGEMENT SHARING POLICY. 4402 03:04:54,240 --> 03:04:58,200 NEXT SLIDE WILL START WAYS IN 4403 03:04:58,200 --> 03:05:00,200 WHICH WE THROUGH THE OFFICE OF 4404 03:05:00,200 --> 03:05:01,560 DATA STRATEGY ARE SUPPORTING 4405 03:05:01,560 --> 03:05:05,440 CAPABILITIES TO MAKE DATA MORE 4406 03:05:05,440 --> 03:05:06,640 FAIR, FINDABLE, ACCESSIBLE, AND 4407 03:05:06,640 --> 03:05:08,560 REASONABLE, A.I. READY. 4408 03:05:08,560 --> 03:05:11,480 FOR THE PAST TWO YEARS WE'VE 4409 03:05:11,480 --> 03:05:13,920 BEEN SUPPORTING SUPPLEMENTS TO 4410 03:05:13,920 --> 03:05:16,040 EXISTING NIH AWARDS, FOR NIH 4411 03:05:16,040 --> 03:05:18,880 RESEARCHERS TO BRING IN 4412 03:05:18,880 --> 03:05:20,640 EXPERTISE IN DATA MANAGEMENT, 4413 03:05:20,640 --> 03:05:21,960 ARTIFICIAL INTELLIGENCE, MACHINE 4414 03:05:21,960 --> 03:05:24,320 LEARNING, COMPUTER SCIENCE, TO 4415 03:05:24,320 --> 03:05:26,880 SUPPORT THE ABILITY TO TAKE 4416 03:05:26,880 --> 03:05:30,000 ALREADY EXISTING NIH DATA AND 4417 03:05:30,000 --> 03:05:31,480 CREATE A.I. READY CAPABILITIES 4418 03:05:31,480 --> 03:05:37,440 FOR THE DATA SUCH AS COMPUTABLE 4419 03:05:37,440 --> 03:05:41,040 METADATA, IMPUTING METADATA THAT 4420 03:05:41,040 --> 03:05:43,320 DOESN'T HAVE METADATA, TIME 4421 03:05:43,320 --> 03:05:47,800 SERIES, ADDITIONS FOR DATA, NEXT 4422 03:05:47,800 --> 03:05:50,760 SLIDE A PARTNERSHIP WITH THE 4423 03:05:50,760 --> 03:05:52,200 DENTAL INSTITUTE. 4424 03:05:52,200 --> 03:05:55,800 YOU'LL HEAR MORE IN A MOMENT 4425 03:05:55,800 --> 03:05:57,480 ABOUT FACEBASE. 4426 03:05:57,480 --> 03:06:00,040 ONE OF OUR SUPPLEMENTS FOR A.I. 4427 03:06:00,040 --> 03:06:03,360 READINESS DATA WAS TO DR. 4428 03:06:03,360 --> 03:06:06,400 CASTLEMAN FOR FACEBASE. 4429 03:06:06,400 --> 03:06:09,360 IT'S A REPOSITIVE TEAR TO SHARE 4430 03:06:09,360 --> 03:06:11,120 DATA GENERATED FROM THE DENTAL 4431 03:06:11,120 --> 03:06:14,200 RESEARCH COMMUNITY. 4432 03:06:14,200 --> 03:06:15,600 THIS SUPPLEMENTS STREAMLINES 4433 03:06:15,600 --> 03:06:20,840 CURATION AND ABILITY TO CURATE 4434 03:06:20,840 --> 03:06:23,040 AND IMPROVE METADATA, 4435 03:06:23,040 --> 03:06:23,720 DESCRIPTIVE ELEMENTS, 4436 03:06:23,720 --> 03:06:26,240 MAINTAINING RESTRICTION ON DATA 4437 03:06:26,240 --> 03:06:26,760 HANDLING. 4438 03:06:26,760 --> 03:06:29,280 I WANT TO POINT TO AN ARTICLE 4439 03:06:29,280 --> 03:06:31,560 THAT IS IN ARCHIVE SYSTEM CALLED 4440 03:06:31,560 --> 03:06:34,120 SHARING BEGINS AT HOME, AN 4441 03:06:34,120 --> 03:06:44,640 ARTICLE WRITTEN BY DR. DEMPSEY, 4442 03:06:44,880 --> 03:06:47,280 FOSTER, FRAZIER, CASTLEMAN, 4443 03:06:47,280 --> 03:06:52,360 RESONATING WITH THE POLICY. 4444 03:06:52,360 --> 03:06:54,120 DATA SHARING REMAINS QUITE LOW. 4445 03:06:54,120 --> 03:06:57,520 WHAT WE HOPE TO HAVE AND WHAT 4446 03:06:57,520 --> 03:06:59,160 THIS ARTICLE IS WAYS RESEARCHERS 4447 03:06:59,160 --> 03:07:01,560 CAN AT THE TIME OF THE INCEPTION 4448 03:07:01,560 --> 03:07:03,160 OF THE EXPERIMENT CREATE FAIR 4449 03:07:03,160 --> 03:07:06,480 DATA, THIS IS REALLY A 4450 03:07:06,480 --> 03:07:07,440 PARTNERSHIP BETWEEN RESEARCH 4451 03:07:07,440 --> 03:07:08,080 COMMUNITY AND REPOSITORY 4452 03:07:08,080 --> 03:07:11,000 COMMUNITY AND OF COURSE THE 4453 03:07:11,000 --> 03:07:14,040 FUNDERS WITH THE SAME GOAL TO 4454 03:07:14,040 --> 03:07:15,760 CREATE DATA THAT'S FAIR AT 4455 03:07:15,760 --> 03:07:16,560 INCEPTION OF RESEARCH PROJECT 4456 03:07:16,560 --> 03:07:19,040 AND NOT AT THE END OF THE 4457 03:07:19,040 --> 03:07:19,840 RESEARCH PROJECT. 4458 03:07:19,840 --> 03:07:22,080 THIS IS SUPPORTED BY OUR DATA 4459 03:07:22,080 --> 03:07:23,240 MANAGEMENT SHARING POLICY. 4460 03:07:23,240 --> 03:07:25,840 SO THE ARTICLE AND SIMILAR 4461 03:07:25,840 --> 03:07:30,120 ARTICLES ARE WORTH CONSIDERING 4462 03:07:30,120 --> 03:07:31,360 AND READING. 4463 03:07:31,360 --> 03:07:33,360 NEXT SLIDE TELLS YOU A LITTLE 4464 03:07:33,360 --> 03:07:37,120 BIT ABOUT THE FACT THAT DATA 4465 03:07:37,120 --> 03:07:38,280 SHARING IS NO ONE-SIZE-FITS-ALL 4466 03:07:38,280 --> 03:07:38,680 SOLUTION. 4467 03:07:38,680 --> 03:07:41,920 THERE'S GOING TO BE MANY WAYS 4468 03:07:41,920 --> 03:07:43,080 RESEARCHERS WOULD LIKE TO SHARE 4469 03:07:43,080 --> 03:07:43,440 DATA. 4470 03:07:43,440 --> 03:07:45,080 I'D LIKE TO TALK ABOUT EACH ONE 4471 03:07:45,080 --> 03:07:46,000 OF THESE OPTIONS. 4472 03:07:46,000 --> 03:07:49,680 BUT AS A FIRST START WE DO 4473 03:07:49,680 --> 03:07:50,440 STRONGLY ENCOURAGE RESEARCHERS 4474 03:07:50,440 --> 03:07:53,480 TO SHARE THEIR DATA IN AN OPEN 4475 03:07:53,480 --> 03:07:57,480 ACCESS DATA SHARING REPOSITORY. 4476 03:07:57,480 --> 03:08:01,720 YOU CAN SEE THEM ON THE 4477 03:08:01,720 --> 03:08:02,880 WEBSITES. 4478 03:08:02,880 --> 03:08:08,120 THESE ARE RESEARCH REPOSITORIES 4479 03:08:08,120 --> 03:08:10,080 SUPPORTED BY COMMUNITIES. 4480 03:08:10,080 --> 03:08:11,160 YOU'LL HEAR ABOUT FACEBASE, 4481 03:08:11,160 --> 03:08:13,920 SUPPORTED BY NIH AND ALIGNS WITH 4482 03:08:13,920 --> 03:08:15,480 THE MISSION, IN THIS CASE THE 4483 03:08:15,480 --> 03:08:17,520 DENTAL INSTITUTE. 4484 03:08:17,520 --> 03:08:18,720 THERE ARE OTHER OPTIONS, I'LL 4485 03:08:18,720 --> 03:08:29,040 TELL YOU ABOUT PubMed, A NEW 4486 03:08:29,040 --> 03:08:30,880 INITIATIVE TO SUPPORT GENERAL 4487 03:08:30,880 --> 03:08:33,080 REPOSITORIES AND BRIEFLY ABOUT 4488 03:08:33,080 --> 03:08:37,880 OUR PARTNERSHIP WITH GOOGLE, 4489 03:08:37,880 --> 03:08:41,680 AWS, MICROSOFT AZURE. 4490 03:08:41,680 --> 03:08:44,440 NEXT SLIDE TELLS ABOUT THE WORK 4491 03:08:44,440 --> 03:08:48,240 THAT NLM HAS BEEN DOING TO ALLOW 4492 03:08:48,240 --> 03:08:50,800 RESEARCHERS TO SHARE THEIR DATA 4493 03:08:50,800 --> 03:08:51,680 TO SUPPLEMENTAL MATERIALS TO 4494 03:08:51,680 --> 03:08:55,440 THEIR ARTICLES IN PubMed 4495 03:08:55,440 --> 03:08:57,720 CENTRAL, SHARED ON THE AWS OPEN 4496 03:08:57,720 --> 03:08:59,840 DATA PLATFORM, YOU CAN SEE A 4497 03:08:59,840 --> 03:09:02,000 LINK AT THE BOTTOM. 4498 03:09:02,000 --> 03:09:07,800 ALL THAT DATA IS AVAILABLE, IT'S 4499 03:09:07,800 --> 03:09:09,320 ABOUT 4 MILLION TO 7 MILLION 4500 03:09:09,320 --> 03:09:10,440 TEXTS, YOU CAN SEARCH AND FIND 4501 03:09:10,440 --> 03:09:17,880 DATA THROUGH THE OPEN DATA 4502 03:09:17,880 --> 03:09:18,160 PLATFORM. 4503 03:09:18,160 --> 03:09:27,520 THE NEXT SLIDE TELLS YOU ABOUT 4504 03:09:27,520 --> 03:09:28,160 SUPPORTING NIH DATA 4505 03:09:28,160 --> 03:09:28,880 REPOSITORIES. 4506 03:09:28,880 --> 03:09:31,880 THERE ARE A VARIETY OF DIFFERENT 4507 03:09:31,880 --> 03:09:33,800 REPOSITORIES OF SIZES AND 4508 03:09:33,800 --> 03:09:36,480 COMPLEXITIES, LEVELS OF 4509 03:09:36,480 --> 03:09:36,760 MATURITY. 4510 03:09:36,760 --> 03:09:40,040 ONE GOAL IS TO HELP REPOSITORIES 4511 03:09:40,040 --> 03:09:42,920 ALONG THE MATURITY LANDSCAPE. 4512 03:09:42,920 --> 03:09:45,480 EACH REPOSITORY BRINGS VALUE TO 4513 03:09:45,480 --> 03:09:47,880 THE RESEARCH AREA, BUT OF COURSE 4514 03:09:47,880 --> 03:09:49,720 WE NEED TO GROW REPOSITORIES SO 4515 03:09:49,720 --> 03:09:51,560 THEY DO REACH A LEVEL OF 4516 03:09:51,560 --> 03:09:53,440 MATURITY AND SOME OF THIS WILL 4517 03:09:53,440 --> 03:09:55,520 BE ALIGNING WITH THE FAIR 4518 03:09:55,520 --> 03:09:58,240 PRINCIPLES AND ALSO TRUST 4519 03:09:58,240 --> 03:09:59,880 PRINCIPLES OF TRANSPARENCY, 4520 03:09:59,880 --> 03:10:01,600 RESPONSIBILITY OF USE, THINKING 4521 03:10:01,600 --> 03:10:08,680 ABOUT THE REPOSITORY AS A USER 4522 03:10:08,680 --> 03:10:09,440 FOLKSED REPOSITORY, ENHANCING 4523 03:10:09,440 --> 03:10:12,600 TECHNOLOGY, BOTH FAIR AND TRUST 4524 03:10:12,600 --> 03:10:14,560 PRINCIPLES ALIGN WITH OST 4525 03:10:14,560 --> 03:10:18,160 DESIRED CHARACTERISTICS FOR DATA 4526 03:10:18,160 --> 03:10:22,440 REPOSITORIES, LINKED ON THE DATA 4527 03:10:22,440 --> 03:10:26,600 MANAGEMENT SHARING POLICY. 4528 03:10:26,600 --> 03:10:33,720 WE WANT TO INSTANTIATE 4529 03:10:33,720 --> 03:10:34,320 INSTANTIATE REPOSITORIES, THE 4530 03:10:34,320 --> 03:10:35,680 NEXT SLIDE IS WORK WE'VE BEEN 4531 03:10:35,680 --> 03:10:38,760 DOING OVER THE PAST TWO YEARS TO 4532 03:10:38,760 --> 03:10:40,200 SUPPORT EXISTING REPOSITORIES 4533 03:10:40,200 --> 03:10:42,880 SUCH AS FACEBASE AND OTHERS TO 4534 03:10:42,880 --> 03:10:45,680 ALIGN WITH THE OSTP PRINCIPLES 4535 03:10:45,680 --> 03:10:47,280 TO INSTANTIATE FAIR DATA AS 4536 03:10:47,280 --> 03:10:49,280 YOU'VE HEARD FROM DR. 4537 03:10:49,280 --> 03:10:51,000 CASTLEMAN'S WORK ON CREATING 4538 03:10:51,000 --> 03:10:52,440 BETTER YOU'RATION TOOL FOR 4539 03:10:52,440 --> 03:10:54,840 METADATA AN TRUST PRINCIPLES AND 4540 03:10:54,840 --> 03:10:57,760 TO HELP EVALUATE USAGE, UTILITY, 4541 03:10:57,760 --> 03:10:58,000 IMPACT. 4542 03:10:58,000 --> 03:10:59,320 NEXT CLICK. 4543 03:10:59,320 --> 03:11:01,080 WE'VE BEEN PROVIDING FUNDING FOR 4544 03:11:01,080 --> 03:11:06,000 REPOSITORIES OF ALL SIZES AND 4545 03:11:06,000 --> 03:11:08,520 STAGES. 4546 03:11:08,520 --> 03:11:13,440 TO INCREASE TRUSTWORTHINESS AND 4547 03:11:13,440 --> 03:11:13,680 FAIRNESS. 4548 03:11:13,680 --> 03:11:15,640 NEXT CLICK. 4549 03:11:15,640 --> 03:11:17,000 ONE MORE. 4550 03:11:17,000 --> 03:11:25,360 WE'VE AWARDED NOW 17 AWARDS, TWO 4551 03:11:25,360 --> 03:11:28,560 FROM IDeA STATES, WE SUPPORT 4552 03:11:28,560 --> 03:11:30,360 INTRAMURAL REPOSITORIES WITH THE 4553 03:11:30,360 --> 03:11:34,200 SAME PRINCIPLES, I WANT TO 4554 03:11:34,200 --> 03:11:35,320 HIGHLIGHT NEXT SLIDE ONE OF THE 4555 03:11:35,320 --> 03:11:38,800 AREAS THAT WE HAVE BEEN 4556 03:11:38,800 --> 03:11:42,000 SUPPORTING THIS FACEBASE, A PLUG 4557 03:11:42,000 --> 03:11:43,840 FOR YOUR COMMUNITY'S DATA 4558 03:11:43,840 --> 03:11:44,240 REPOSITORY. 4559 03:11:44,240 --> 03:11:47,120 HOLDING DATA NOT ONLY ON NORMAL 4560 03:11:47,120 --> 03:11:48,680 BUT ABNORMAL CRANIOFACIAL AND 4561 03:11:48,680 --> 03:11:50,080 DENTAL DEVELOPMENT IN HUMAN AND 4562 03:11:50,080 --> 03:11:53,160 ANIMAL MODELS, HAS OVER A 4563 03:11:53,160 --> 03:11:55,760 THOUSAND DATASETS, AND 200 4564 03:11:55,760 --> 03:11:58,280 PUBLICATIONS, ASSOCIATED 4565 03:11:58,280 --> 03:11:59,080 PUBLICATIONS, SOMETHING WE 4566 03:11:59,080 --> 03:12:00,840 ARTICULATED EARLY ON, LINKING 4567 03:12:00,840 --> 03:12:06,480 DATA IN THE PUBLICATIONS TO THE 4568 03:12:06,480 --> 03:12:07,160 REPOSITORY SO RESEARCHESSERS CAN 4569 03:12:07,160 --> 03:12:10,800 FIND AND USE THE DATA. 4570 03:12:10,800 --> 03:12:12,400 IT ALSO HAS ANALYTIC 4571 03:12:12,400 --> 03:12:12,880 CAPABILITIES. 4572 03:12:12,880 --> 03:12:13,840 EMPOWERS SCIENTISTS TO THINK 4573 03:12:13,840 --> 03:12:16,520 ABOUT BEST PRACTICES FOR DATA 4574 03:12:16,520 --> 03:12:19,440 SHARING AND DATA CITATION. 4575 03:12:19,440 --> 03:12:21,520 AND HELPING REALLY PRODUCE THAT 4576 03:12:21,520 --> 03:12:23,360 COMMUNITY OF DATA REUSE AND 4577 03:12:23,360 --> 03:12:25,680 REPRODUCIBILITY, I HOPE YOU IF 4578 03:12:25,680 --> 03:12:26,480 YOU HAVEN'T EXPLORED IT YOU'LL 4579 03:12:26,480 --> 03:12:27,960 HAVE THE OPPORTUNITY TO DO SO. 4580 03:12:27,960 --> 03:12:32,560 THERE'S MORE OPPORTUNITIES TO 4581 03:12:32,560 --> 03:12:33,880 CONNECT TO INTEROPERABILITY WITH 4582 03:12:33,880 --> 03:12:36,960 OTHERS ACTIVITIES WE'RE 4583 03:12:36,960 --> 03:12:38,080 SUPPORTING AT NIH INCLUDING ALL 4584 03:12:38,080 --> 03:12:44,960 OF US AND OUR CLINICAL AND 4585 03:12:44,960 --> 03:12:47,480 GENOMICS DATA REPOSITORIES. 4586 03:12:47,480 --> 03:12:50,560 WE HAVE PROGRAMS THAT SUPPORT 4587 03:12:50,560 --> 03:12:52,880 DATA REPOSITORIES AND KNOWLEDGE 4588 03:12:52,880 --> 03:12:54,080 BASES AS RESOURCES SO THESE 4589 03:12:54,080 --> 03:12:55,760 ACTIVITIES DO NOT NEED TO COME 4590 03:12:55,760 --> 03:12:57,320 IN THROUGH THE R01 GRANTING 4591 03:12:57,320 --> 03:12:58,840 MECHANISM WHICH IS NOT ALIGNED 4592 03:12:58,840 --> 03:13:00,760 TO A DATA REPOSITORY OF 4593 03:13:00,760 --> 03:13:02,520 KNOWLEDGE BASE BUT RATHER WILL 4594 03:13:02,520 --> 03:13:06,520 SUPPORT THESE PROGRAMS WITH A 4595 03:13:06,520 --> 03:13:07,920 SPECIAL EMPHASIS REVIEW PANEL TO 4596 03:13:07,920 --> 03:13:10,960 FILM A GAP IN NIH MISSION I.C. 4597 03:13:10,960 --> 03:13:13,240 TO ENCOURAGE ADOPTION OF GOOD 4598 03:13:13,240 --> 03:13:16,000 DATA MANAGEMENT PRACTICES. 4599 03:13:16,000 --> 03:13:17,520 AND TO ENGAGE RESEARCH COMMUNITY 4600 03:13:17,520 --> 03:13:21,440 IN TRAINING ON FAIR DATA AND 4601 03:13:21,440 --> 03:13:22,440 CREATING DATA THAT'S FAIR AT THE 4602 03:13:22,440 --> 03:13:24,440 BEGINNING OF THE EXPERIMENT AS 4603 03:13:24,440 --> 03:13:26,560 WELL AS ENABLING GREATER REUSE 4604 03:13:26,560 --> 03:13:27,680 OF DATA. 4605 03:13:27,680 --> 03:13:32,640 OF COURSE THINKING ABOUT DATA 4606 03:13:32,640 --> 03:13:38,000 GOVERNANCE IN TERMS OF LIFE 4607 03:13:38,000 --> 03:13:39,320 CYCLE APPROACH. 4608 03:13:39,320 --> 03:13:40,400 THE NEXT CLICK, AWARDS IN THE 4609 03:13:40,400 --> 03:13:50,680 PAST TWO YEARS. 4610 03:13:50,960 --> 03:13:53,960 SOME ARE FAMILIAR, BIOPORTAL, 4611 03:13:53,960 --> 03:13:54,720 UNIPROT. 4612 03:13:54,720 --> 03:14:00,320 LOOK AT PARS, REISSUED IN 2023, 4613 03:14:00,320 --> 03:14:01,320 SLIGHT MODIFICATIONS, 4614 03:14:01,320 --> 03:14:02,480 PARTITIONING A FUNDING 4615 03:14:02,480 --> 03:14:04,880 ANNOUNCEMENT TO EARLY STAGE 4616 03:14:04,880 --> 03:14:06,240 REPOSITORIES, AND TO 4617 03:14:06,240 --> 03:14:09,520 REPOSITORIES THAT ARE FAIRLY 4618 03:14:09,520 --> 03:14:12,600 MATURE SUCH AS UNIPROT FOR 4619 03:14:12,600 --> 03:14:13,000 EXAMPLE. 4620 03:14:13,000 --> 03:14:15,000 I HOPE YOU'LL FOLLOW US ON OUR 4621 03:14:15,000 --> 03:14:22,120 JOURNEY AS WE SUPPORT DATA 4622 03:14:22,120 --> 03:14:23,360 REPOSITORIES AND KNOWLEDGE 4623 03:14:23,360 --> 03:14:27,480 BASES, ALIGNING WITH WHAT'S 4624 03:14:27,480 --> 03:14:29,040 HAPPENING IN EUROPE, IN THE 4625 03:14:29,040 --> 03:14:33,600 GLOBAL DATA COALITION. 4626 03:14:33,600 --> 03:14:35,040 NEXT SLIDE. 4627 03:14:35,040 --> 03:14:38,440 IT ILLUSTRATES WORK WE'RE DOING 4628 03:14:38,440 --> 03:14:39,720 WITH THE GENERALIST 4629 03:14:39,720 --> 03:14:40,600 REPOSITORIES. 4630 03:14:40,600 --> 03:14:43,680 RESEARCHERS MAY CHOOSE TO SHARE 4631 03:14:43,680 --> 03:14:46,200 DATA IN PUBMED CENTRAL. 4632 03:14:46,200 --> 03:14:54,320 OR MAY CHOOSE A COMMUNITY-DRIVEN 4633 03:14:54,320 --> 03:14:58,400 REPOSITORY SUCH AS FACEBASE OR 4634 03:14:58,400 --> 03:14:58,920 OTHERS. 4635 03:14:58,920 --> 03:15:09,440 WE'VE INITIATED A NEW PROGRAM, 4636 03:15:11,680 --> 03:15:12,760 GENERALIST REPOSITORY ECOSYSTEM, 4637 03:15:12,760 --> 03:15:13,480 CHARACTERISTICS CONSISTENT 4638 03:15:13,480 --> 03:15:16,320 METADATA, FOR EXAMPLE, SO THAT 4639 03:15:16,320 --> 03:15:21,160 WE CAN BETTER DISCOVER AND FIND 4640 03:15:21,160 --> 03:15:26,720 AND REUSE NIH-SUPPORTED DATA, 4641 03:15:26,720 --> 03:15:28,680 CONDUCTING OUTREACH AND ENGAGING 4642 03:15:28,680 --> 03:15:31,720 RESEARCH COMMUNITY TO ENCOURAGE 4643 03:15:31,720 --> 03:15:33,480 SECONDARY REUSE OF DATA, THIS 4644 03:15:33,480 --> 03:15:35,040 KICKED OFF IN EARLY JANUARY. 4645 03:15:35,040 --> 03:15:36,760 WE'RE A FEW MONTHS IN BUT I HOPE 4646 03:15:36,760 --> 03:15:39,840 YOU'LL WORK WITH US AS WE WORK 4647 03:15:39,840 --> 03:15:41,040 WITH OUR GENERALIST REPOSITORIES 4648 03:15:41,040 --> 03:15:44,360 TO CREATE A BETTER AND MORE 4649 03:15:44,360 --> 03:15:46,080 SUSTAINABLE DATA ECOSYSTEM 4650 03:15:46,080 --> 03:15:47,280 ACROSS OUR REPOSITORIES 4651 03:15:47,280 --> 03:15:53,320 ENHANCING FAIR DATA AND DATA 4652 03:15:53,320 --> 03:15:54,320 SHARING. 4653 03:15:54,320 --> 03:15:58,360 SOME THOUGHT QUESTIONS FOR THE 4654 03:15:58,360 --> 03:16:00,200 COMMUNITY WAYS TO 4655 03:16:00,200 --> 03:16:01,400 RETROSPECTIVELY AND PROACTIVELY 4656 03:16:01,400 --> 03:16:02,720 ENHANCE FAIR DATA, FAIR AT 4657 03:16:02,720 --> 03:16:03,840 CREATION OF EXPERIMENT AND 4658 03:16:03,840 --> 03:16:06,000 THINKING ABOUT WAYS IN WHICH WE 4659 03:16:06,000 --> 03:16:07,840 CAN SHARE DATA THROUGHOUT ITS 4660 03:16:07,840 --> 03:16:08,440 LIFE CYCLE. 4661 03:16:08,440 --> 03:16:09,480 IMPROVING, FOR EXAMPLE, THE WAYS 4662 03:16:09,480 --> 03:16:11,800 IN WHICH WE CAN CAPTURE METADATA 4663 03:16:11,800 --> 03:16:17,040 AND EXTRACT IT TO ALLOW FOR 4664 03:16:17,040 --> 03:16:19,280 GREATER DISCOVERABILITY. 4665 03:16:19,280 --> 03:16:20,240 CONNECTING REPOSITORIES AS WELL 4666 03:16:20,240 --> 03:16:22,320 AS WAYS TO BETTER STORE AND 4667 03:16:22,320 --> 03:16:25,280 MANAGE AND INTEGRATE DIVERSE 4668 03:16:25,280 --> 03:16:26,120 DATASETS, JUST SOME THOUGHTS, US 4669 03:16:26,120 --> 03:16:29,040 A WORK WITH YOUR GROUP YOU'LL 4670 03:16:29,040 --> 03:16:30,560 CONSIDER SOME OF THESE. 4671 03:16:30,560 --> 03:16:33,160 I'LL TALK BRIEFLY ON THE NEXT 4672 03:16:33,160 --> 03:16:36,680 SLIDE ABOUT OUR PARTNERSHIP WITH 4673 03:16:36,680 --> 03:16:40,240 GOOGLE, AWS, MICROSOFT AZURE, 4674 03:16:40,240 --> 03:16:44,320 STRIDES PARTNERSHIP, TO PROVIDE 4675 03:16:44,320 --> 03:16:46,480 RESEARCHERS ABILITY TO STORE AND 4676 03:16:46,480 --> 03:16:50,520 ANALYZE IN A CLOUD ENVIRONMENT 4677 03:16:50,520 --> 03:16:53,960 WITH ACCESS TO PROFESSIONAL 4678 03:16:53,960 --> 03:16:54,760 SERVICES, POTENTIAL 4679 03:16:54,760 --> 03:16:55,920 COLLABORATIONS. 4680 03:16:55,920 --> 03:16:57,000 YOU'LL SEE A SNAPSHOT, THIS 4681 03:16:57,000 --> 03:17:00,080 MIGHT BE FROM EARLY MAY. 4682 03:17:00,080 --> 03:17:03,120 WE STORED OVER -- NOW OVER 170 4683 03:17:03,120 --> 03:17:05,680 PETABYTES OF DATA ON OUR THREE 4684 03:17:05,680 --> 03:17:07,520 CLOUD SERVICE PROVIDERS, 4685 03:17:07,520 --> 03:17:09,240 MANAGING AND ACCESSING AND 4686 03:17:09,240 --> 03:17:12,360 COMPUTING THIS AMOUNT OF DATA IS 4687 03:17:12,360 --> 03:17:14,920 A GRAND CHALLENGE. 4688 03:17:14,920 --> 03:17:17,440 WE'VE TRAINED OVER 4,000 PEOPLE, 4689 03:17:17,440 --> 03:17:19,320 AND WORKED WITH OVER 700 4690 03:17:19,320 --> 03:17:21,960 PROGRAMS AND PROJECTS IN OUR 4691 03:17:21,960 --> 03:17:26,000 STRIDES PROGRAM. 4692 03:17:26,000 --> 03:17:29,320 WE UNDERSTAND UTILIZING THE 4693 03:17:29,320 --> 03:17:31,920 CLOUD IS A HEAVY LIFT AND 4694 03:17:31,920 --> 03:17:33,200 RESEARCHERS NEED A SANDBOX TO 4695 03:17:33,200 --> 03:17:35,400 EXPLORE THE CLOUD, THE WAYS YOU 4696 03:17:35,400 --> 03:17:37,160 CAN CONFIGURE THE ARCHITECTURE 4697 03:17:37,160 --> 03:17:40,120 OF CLOUD PROVIDERS, AND 4698 03:17:40,120 --> 03:17:41,120 POTENTIALLY SUPPLEMENT THROUGH 4699 03:17:41,120 --> 03:17:43,200 EXISTING TRAINING. 4700 03:17:43,200 --> 03:17:47,000 NEXT SLIDE TELLS YOU ABOUT A 4701 03:17:47,000 --> 03:17:49,880 PROGRAM WE LAUNCHED IN APRIL, 4702 03:17:49,880 --> 03:17:51,400 ALLOWS RESEARCHERS TO TRY THE 4703 03:17:51,400 --> 03:17:54,480 CLOUD BEFORE YOU COMMIT, YOU CAN 4704 03:17:54,480 --> 03:17:56,600 UPLOAD YOUR DATA, UPLOAD YOUR 4705 03:17:56,600 --> 03:17:57,600 TOOLS OR APPLICATIONS, OR USE 4706 03:17:57,600 --> 03:18:00,920 SOME OF THOSE THAT ARE ALREADY 4707 03:18:00,920 --> 03:18:06,080 IN THE CLOUD LAB TO EXPLORE THE 4708 03:18:06,080 --> 03:18:08,040 FIELD, THE ENVIRONMENT, WE ALSO 4709 03:18:08,040 --> 03:18:13,440 PROVIDE TRAINING, TRAINING COULD 4710 03:18:13,440 --> 03:18:15,200 BE IN JUPYTER NOTEBOOK BOOKS, WE 4711 03:18:15,200 --> 03:18:17,560 HAVE A NUMBER OF ANALYTIC 4712 03:18:17,560 --> 03:18:19,160 CAPABILITIES ALREADY. 4713 03:18:19,160 --> 03:18:21,680 FOR EXAMPLE, GWAS ANALYSIS, 4714 03:18:21,680 --> 03:18:22,960 MEDICAL IMAGING ANALYSIS. 4715 03:18:22,960 --> 03:18:27,480 CAN EXPERIMENT WITH DIFFERENT 4716 03:18:27,480 --> 03:18:29,400 CLOUD SOLUTIONS, TRY ONE OR ALL, 4717 03:18:29,400 --> 03:18:31,200 BENCHMARK WITH A HIGH-THROUGHPUT 4718 03:18:31,200 --> 03:18:35,040 WORKFLOW CAN BENCHMARK TOOLS AND 4719 03:18:35,040 --> 03:18:36,200 CONFIGURATIONS, OPTIMIZE YOUR 4720 03:18:36,200 --> 03:18:36,400 WORK. 4721 03:18:36,400 --> 03:18:38,800 I HOPE AS WE ROLL THIS OUT TO 4722 03:18:38,800 --> 03:18:40,480 THE EXTRAMURAL COMMUNITY IT'S 4723 03:18:40,480 --> 03:18:42,560 NOW BEING TESTED IN INTRAMURAL 4724 03:18:42,560 --> 03:18:43,880 COMMUNITY, YOU'LL ENGAGE WITH US 4725 03:18:43,880 --> 03:18:46,400 AS OUR AIM IS TO REALLY PROVIDE 4726 03:18:46,400 --> 03:18:50,160 YOU WITH MANY DIFFERENT TYPES OF 4727 03:18:50,160 --> 03:18:52,000 SOLUTIONS FOR DATA STORAGE 4728 03:18:52,000 --> 03:18:54,080 MANAGEMENT AND COMPUTE TO FIT 4729 03:18:54,080 --> 03:18:59,240 YOUR RESEARCH NEEDS. 4730 03:18:59,240 --> 03:19:00,840 NEXT SLIDE, I WANT TO SPEND A 4731 03:19:00,840 --> 03:19:05,240 SHORT AMOUNT OF TIME TO DISCUSS 4732 03:19:05,240 --> 03:19:09,120 THE WORK WE'RE DOING TO IMPROVE 4733 03:19:09,120 --> 03:19:12,640 OUR SOFTWARE CAPABILITIES, PART 4734 03:19:12,640 --> 03:19:14,240 OF OUR DATA ECOSYSTEM. 4735 03:19:14,240 --> 03:19:20,520 NEXT SLIDE IS OUR PARTNERSHIP 4736 03:19:20,520 --> 03:19:21,360 WITH NATIONAL SCIENCE 4737 03:19:21,360 --> 03:19:21,800 FOUNDATION. 4738 03:19:21,800 --> 03:19:27,800 THE GOAL IS TO BRING IN COMPUTER 4739 03:19:27,800 --> 03:19:32,440 SCIENTISTS AND ENGINEERS INTO 4740 03:19:32,440 --> 03:19:33,400 THE BIOMEDICAL WORKSPACE, SINCE 4741 03:19:33,400 --> 03:19:35,520 I DON'T HAVE A LOT OF TIME I 4742 03:19:35,520 --> 03:19:39,000 WANT TO HIGHLIGHT ONE AWARD FROM 4743 03:19:39,000 --> 03:19:40,320 THIS PROGRAM RECENTLY, DR. RONG 4744 03:19:40,320 --> 03:19:43,680 WANG FROM ILLINOIS INSTITUTE OF 4745 03:19:43,680 --> 03:19:45,440 TECHNOLOGY, HE'S DEVELOPING A 4746 03:19:45,440 --> 03:19:47,800 FAIRLY RAPID AND USER PRESENTLY 4747 03:19:47,800 --> 03:19:49,880 LOW COST POINT OF CARE DEVICE IN 4748 03:19:49,880 --> 03:19:54,360 THE DENTIST OFFICE OR AT HOME TO 4749 03:19:54,360 --> 03:19:56,640 INTEGRATE AND ANALYZE DIFFERENT 4750 03:19:56,640 --> 03:20:00,440 TYPES OF DATA THAT UNDERLIE 4751 03:20:00,440 --> 03:20:01,680 DENTAL AND ORAL CARE. 4752 03:20:01,680 --> 03:20:06,160 THIS IS ONE EXAMPLE OF THE MANY 4753 03:20:06,160 --> 03:20:07,040 DIFFERENT R01s THAT IS 4754 03:20:07,040 --> 03:20:08,480 SUPPORTED BY ALL OUR INSTITUTES 4755 03:20:08,480 --> 03:20:09,280 AND CENTERS. 4756 03:20:09,280 --> 03:20:12,160 I HOPE YOU'LL CONSIDER THIS IF 4757 03:20:12,160 --> 03:20:14,040 YOU'RE INTERESTED IN COMPUTERS, 4758 03:20:14,040 --> 03:20:17,000 INTEGRATION OF COMPUTER SCIENCE, 4759 03:20:17,000 --> 03:20:18,480 DENTAL HEALTH RESEARCH. 4760 03:20:18,480 --> 03:20:21,160 IMPLICATIONS ARE MANAGED BY NSF 4761 03:20:21,160 --> 03:20:24,120 FOR REVIEW AND ONCE REVIEWED THE 4762 03:20:24,120 --> 03:20:26,960 APPLICATIONS ARE BROUGHT TO NIH 4763 03:20:26,960 --> 03:20:31,200 FOR FUNDING. 4764 03:20:31,200 --> 03:20:32,400 THE NEXT SLIDE TELLS YOU ABOUT 4765 03:20:32,400 --> 03:20:35,160 THE WORK THAT WE'RE DOING TO 4766 03:20:35,160 --> 03:20:39,280 ENHANCE EXISTING NIH SOFTWARE 4767 03:20:39,280 --> 03:20:42,400 AND TOOLS TO PROMOTE SOFTWARE 4768 03:20:42,400 --> 03:20:43,640 ENGINEERING, TO ESTABLISH 4769 03:20:43,640 --> 03:20:44,360 COLLABORATIONS BETWEEN 4770 03:20:44,360 --> 03:20:45,680 RESEARCHERS WHO ALREADY ARE 4771 03:20:45,680 --> 03:20:47,080 FUNDED BY NIH, AND THOSE WHO 4772 03:20:47,080 --> 03:20:49,920 WOULD LIKE TO BRING ON COMPUTER 4773 03:20:49,920 --> 03:20:50,920 SCIENTISTS AND SOFTWARE 4774 03:20:50,920 --> 03:20:53,200 ENGINEERS INTO THE PROGRAMS AND 4775 03:20:53,200 --> 03:20:53,520 R01s. 4776 03:20:53,520 --> 03:20:56,480 IN ORDER TO MAKE TOOLS 4777 03:20:56,480 --> 03:20:58,360 SUSTAINABLE, TO, FOR EXAMPLE, 4778 03:20:58,360 --> 03:21:01,640 ENABLE MULTI-CLOUD COMPUTING, 4779 03:21:01,640 --> 03:21:02,840 HYBRID COMPUTING, INCLUDE REUSE 4780 03:21:02,840 --> 03:21:04,840 OF SOFTWARE YOU HAVE DEVELOPED 4781 03:21:04,840 --> 03:21:06,880 ALREADY SO THE NEXT SLIDE IS 4782 03:21:06,880 --> 03:21:09,240 JUST AN EXAMPLE OF SOME OF THE 4783 03:21:09,240 --> 03:21:11,320 TYPES OF RECENT AWARDS THAT 4784 03:21:11,320 --> 03:21:14,440 WE'VE BEEN MAKING, I WANT TO 4785 03:21:14,440 --> 03:21:18,280 HIGHLIGHT THE AWARD BY DR. 4786 03:21:18,280 --> 03:21:20,480 EMONDI FROM BOSTON UNIVERSITY, 4787 03:21:20,480 --> 03:21:21,520 CANDIDATE DRIVER ANALYSIS, WHAT 4788 03:21:21,520 --> 03:21:26,040 HE'S GOING TO BE DOING, TO 4789 03:21:26,040 --> 03:21:27,360 OPTIMIZE AND CONTAINERIZE WORK 4790 03:21:27,360 --> 03:21:30,320 SO IT BECOMES MORE USER FRIENDLY 4791 03:21:30,320 --> 03:21:33,360 AND OPEN SOURCE. 4792 03:21:33,360 --> 03:21:35,160 IT'S WORKING AT PICKING 4793 03:21:35,160 --> 03:21:36,560 MULTIOMICS DATASETS FROM HEAD 4794 03:21:36,560 --> 03:21:39,840 AND NECK CANCER TO IMPROVE THE 4795 03:21:39,840 --> 03:21:41,680 ANALYSIS CAPABILITY OF THOSE 4796 03:21:41,680 --> 03:21:41,960 DATASETS. 4797 03:21:41,960 --> 03:21:44,440 I THINK THIS IS SOMETHING THAT 4798 03:21:44,440 --> 03:21:45,880 IF YOU'RE INTERESTED IN PLEASE 4799 03:21:45,880 --> 03:21:49,200 DO LOOK FOR THE SUPPLEMENTS, 4800 03:21:49,200 --> 03:21:51,240 WE'RE ALWAYS ENGAGING THE 4801 03:21:51,240 --> 03:21:52,920 COMMUNITY TO ENHANCE THE 4802 03:21:52,920 --> 03:21:54,080 SOFTWARE PRACTICES OF THE WORK 4803 03:21:54,080 --> 03:21:55,320 THAT WE'RE DOING. 4804 03:21:55,320 --> 03:21:57,800 THE NEXT SLIDE IS JUST A QUICK 4805 03:21:57,800 --> 03:21:59,720 THOUGHT ON WHERE WE'RE THINKING 4806 03:21:59,720 --> 03:22:04,960 OF GOING IN TERMS OF EXPLAINING 4807 03:22:04,960 --> 03:22:05,800 PARADIGMS FOR LOCOED 4808 03:22:05,800 --> 03:22:07,440 PERFORMANCE, EDGE COMPUTING AS 4809 03:22:07,440 --> 03:22:11,400 WELL AS HUMAN SOFTWARE 4810 03:22:11,400 --> 03:22:12,440 AUGMENTATION. 4811 03:22:12,440 --> 03:22:14,560 I WANT TO SPEND A MOMENT AND 4812 03:22:14,560 --> 03:22:23,880 NEXT FEW SLIDES TO TALK ABOUT 4813 03:22:23,880 --> 03:22:25,640 SOME ACTIVITIES, BUT I NEED TO 4814 03:22:25,640 --> 03:22:28,240 TELL YOU ABOUT THE WORK WE'RE 4815 03:22:28,240 --> 03:22:29,200 DOING GENERALLY IN ELECTRONIC 4816 03:22:29,200 --> 03:22:32,160 HEALTH CARE RECORD DATA FOR 4817 03:22:32,160 --> 03:22:32,760 RESEARCH. 4818 03:22:32,760 --> 03:22:34,320 I'M SURE YOU'RE FAMILIAR WITH 4819 03:22:34,320 --> 03:22:36,960 THE STATE OF THE ART OF 4820 03:22:36,960 --> 03:22:37,880 ELECTRONIC HEALTH RECORDS, AND 4821 03:22:37,880 --> 03:22:42,360 RICH AMOUNT OF DATA THAT ONE CAN 4822 03:22:42,360 --> 03:22:45,760 GET FROM THESE RECORDS THAT 4823 03:22:45,760 --> 03:22:46,760 BASICALLY DESCRIBE ENCOUNTERS 4824 03:22:46,760 --> 03:22:48,720 PATIENTS HAVE WITH OUR HEALTH 4825 03:22:48,720 --> 03:22:50,640 CARE PROVIDER SYSTEMS. 4826 03:22:50,640 --> 03:22:55,480 THEY ARE OFTEN DIVERSE DATA, LAB 4827 03:22:55,480 --> 03:22:56,640 DATA, IMAGING DATA, BUT THESE 4828 03:22:56,640 --> 03:22:57,640 RECORDS ARE DEVELOPED FOR 4829 03:22:57,640 --> 03:22:59,080 BILLING AND HEALTH CARE 4830 03:22:59,080 --> 03:23:00,960 PRACTICES, NOT FOR RESEARCH. 4831 03:23:00,960 --> 03:23:03,480 SO CREATING A WORLD IN WHICH 4832 03:23:03,480 --> 03:23:04,720 ELECTRONIC HEALTH CARE DATA CAN 4833 03:23:04,720 --> 03:23:06,760 BE USED FOR RESEARCH PURPOSES IS 4834 03:23:06,760 --> 03:23:07,920 SOMETHING NOT JUST OUR OFFICE 4835 03:23:07,920 --> 03:23:09,800 BUT MANY I.C.s HAVE BEEN 4836 03:23:09,800 --> 03:23:12,880 WORKING ON. 4837 03:23:12,880 --> 03:23:13,960 NEXT SLIDE. 4838 03:23:13,960 --> 03:23:17,280 IT TALKS ABOUT WAYS WE'RE 4839 03:23:17,280 --> 03:23:18,800 UTILIZING THE FHIR STANDARDS 4840 03:23:18,800 --> 03:23:24,480 WHICH HAVE BEEN DEVELOPED TO 4841 03:23:24,480 --> 03:23:27,800 HARMONIZE ACROSS VENDORS LIKE 4842 03:23:27,800 --> 03:23:31,960 EPPIC TO ENHANCE DATA SHAKER AND 4843 03:23:31,960 --> 03:23:33,280 INTEROPERABILITY TO ENABLE 4844 03:23:33,280 --> 03:23:35,760 RESEARCHERS TO MAP DIFFERENT 4845 03:23:35,760 --> 03:23:37,200 ELECTRONIC SYSTEMS ON ONE 4846 03:23:37,200 --> 03:23:40,240 STANDARD, SOMETHING WE'VE BEEN 4847 03:23:40,240 --> 03:23:41,720 DOING DURING COVID TIMES. 4848 03:23:41,720 --> 03:23:45,640 WORKING TO MAKE SURE WE CAN 4849 03:23:45,640 --> 03:23:47,400 SHARE DATA BROADLY AND SUPPORT 4850 03:23:47,400 --> 03:23:49,920 SECONDARY REUSE OF THIS DATA. 4851 03:23:49,920 --> 03:23:52,320 THIS IS TAKING QUITE A BIT OF 4852 03:23:52,320 --> 03:23:52,600 TRAINING. 4853 03:23:52,600 --> 03:23:54,600 I'LL TELL YOU IN THE NEXT SLIDE 4854 03:23:54,600 --> 03:23:58,320 A FEW ACTIVITIES WE'VE BEEN 4855 03:23:58,320 --> 03:24:02,920 DOING TO SUPPORT FHIR. 4856 03:24:02,920 --> 03:24:07,080 INCLUDING SMART ON FHIR APP SO 4857 03:24:07,080 --> 03:24:10,480 RESEARCHERS CAN DOWNLOAD DATA, 4858 03:24:10,480 --> 03:24:11,760 FOR EXAMPLE UNDERSTANDING 4859 03:24:11,760 --> 03:24:13,880 CHRONIC CONDITIONS, THE EMERGE 4860 03:24:13,880 --> 03:24:17,480 NETWORK LOOKING AT NAPPING 4861 03:24:17,480 --> 03:24:18,360 GENOMICS AND PHENOTYPIC DATA 4862 03:24:18,360 --> 03:24:19,640 INTO ELECTRONIC HEALTH CARE 4863 03:24:19,640 --> 03:24:27,080 RECORD DATA FEAR A FHIR-BASED 4864 03:24:27,080 --> 03:24:29,400 SCHEMA AND APIs TO STANDARDIZE 4865 03:24:29,400 --> 03:24:30,720 DATA, ACROSS LARGE COHORT 4866 03:24:30,720 --> 03:24:33,880 STUDIES BY MAPPING THOSE INTO A 4867 03:24:33,880 --> 03:24:35,080 FHIR STANDARDS. 4868 03:24:35,080 --> 03:24:37,880 ENCOURAGING RESEARCHERS TO USE 4869 03:24:37,880 --> 03:24:38,920 FHIR IN CLINICAL DATA 4870 03:24:38,920 --> 03:24:39,720 ACTIVITIES. 4871 03:24:39,720 --> 03:24:42,800 AND THEN OF COURSE TO USE FHIR 4872 03:24:42,800 --> 03:24:44,560 AS RESOURCES FOR TRANSLATIONAL 4873 03:24:44,560 --> 03:24:47,760 NETWORKS, JUST A FEW OF THE 4874 03:24:47,760 --> 03:24:50,360 PROGRAMS THAT NIH HAS BEEN 4875 03:24:50,360 --> 03:24:53,120 WORKING ON TO ENHANCE THE USE OF 4876 03:24:53,120 --> 03:24:55,280 CLINICAL RECORDS, USING FHIR 4877 03:24:55,280 --> 03:24:56,360 STANDARDS, BUT THERE'S QUITE A 4878 03:24:56,360 --> 03:24:57,800 BIT OF TRAINING THAT NEEDS TO 4879 03:24:57,800 --> 03:25:00,080 HAPPEN SO THE NEXT SLIDE WILL 4880 03:25:00,080 --> 03:25:01,520 TELL YOU ABOUT THE TRAINING 4881 03:25:01,520 --> 03:25:05,520 WE'VE BEEN DOING SINCE DECEMBER. 4882 03:25:05,520 --> 03:25:06,120 OF 2021. 4883 03:25:06,120 --> 03:25:10,600 SO GO TO THE NEXT SLIDE. 4884 03:25:10,600 --> 03:25:12,360 WE'VE BEEN WORKING ACROSS NIH 4885 03:25:12,360 --> 03:25:14,880 AND CLINICAL CENTER AND OUR 4886 03:25:14,880 --> 03:25:17,720 INSTITUTIONS TO PROVIDE TAILORED 4887 03:25:17,720 --> 03:25:20,560 TRAINING TO NIH RESEARCHERS ON 4888 03:25:20,560 --> 03:25:23,120 FHIR, AND USING FHIR WITH 4889 03:25:23,120 --> 03:25:28,880 DIFFERENT PROGRAMS SUCH AS R OR 4890 03:25:28,880 --> 03:25:29,880 PYTHON. 4891 03:25:29,880 --> 03:25:31,000 WE'RE NOW LOOKING TO MOVE 4892 03:25:31,000 --> 03:25:32,960 TRAINING ON FHIR TO EXTRAMURAL 4893 03:25:32,960 --> 03:25:34,120 COMMUNITY, DEMONSTRATING HOW YOU 4894 03:25:34,120 --> 03:25:36,240 CAN EXTRACT HEALTH CARE DATA, 4895 03:25:36,240 --> 03:25:37,760 USING FHIR STANDARDS FOR THE 4896 03:25:37,760 --> 03:25:45,200 PURPOSES OF RESEARCH, WE PROVIDE 4897 03:25:45,200 --> 03:25:47,160 TRAINING ON MITRE AND WILL 4898 03:25:47,160 --> 03:25:48,560 PROVIDE TRAINING ON COMPLEX 4899 03:25:48,560 --> 03:25:51,440 EXERCISES THAT YOU MAY HAVE FOR 4900 03:25:51,440 --> 03:25:52,200 RESEARCH QUESTIONS, ALL THIS 4901 03:25:52,200 --> 03:25:55,400 TRAINING IS ALSO WITH A HANDS-ON 4902 03:25:55,400 --> 03:25:55,720 EXPERIENCE. 4903 03:25:55,720 --> 03:25:58,880 SO THIS IS SOMETHING TO LOOK 4904 03:25:58,880 --> 03:25:59,760 FORWARD TO. 4905 03:25:59,760 --> 03:26:01,160 NEXT SLIDE IS THOUGHTS. 4906 03:26:01,160 --> 03:26:03,200 THERE'S BEEN GOOD MOVEMENT 4907 03:26:03,200 --> 03:26:05,680 RECENTLY IN HL7 AND FHIR, 4908 03:26:05,680 --> 03:26:06,520 INTEGRATING ELECTRONIC MEDICAL 4909 03:26:06,520 --> 03:26:08,600 RECORDS AND DENTAL RECORDS SO 4910 03:26:08,600 --> 03:26:11,440 IT'S WORTH LOOKING AT THE DENTAL 4911 03:26:11,440 --> 03:26:12,480 DATA EXCHANGE IN HL7. 4912 03:26:12,480 --> 03:26:15,000 I CAN PUT THE LINK IN THE ZOOM 4913 03:26:15,000 --> 03:26:15,680 CHAT. 4914 03:26:15,680 --> 03:26:18,080 I THINK THERE'S GOOD 4915 03:26:18,080 --> 03:26:18,720 OPPORTUNITIES TO INTEGRATE 4916 03:26:18,720 --> 03:26:19,640 ELECTRONIC HEALTH CARE RECORD 4917 03:26:19,640 --> 03:26:22,800 AND DENTAL RECORD FOR A MUCH 4918 03:26:22,800 --> 03:26:25,120 MORE HOLISTIC VIEW OF THE 4919 03:26:25,120 --> 03:26:26,960 PATIENT'S HEALTH AND DISEASE 4920 03:26:26,960 --> 03:26:27,280 PROGRESSION. 4921 03:26:27,280 --> 03:26:29,800 SO I HOPE THIS IS SOMETHING THAT 4922 03:26:29,800 --> 03:26:31,400 AS YOU'RE WORKING THROUGH 4923 03:26:31,400 --> 03:26:32,960 WORKING GROUPS YOU'LL THINK 4924 03:26:32,960 --> 03:26:35,280 ABOUT WAYS TO LEVERAGE HEALTH 4925 03:26:35,280 --> 03:26:37,520 CARE SYSTEM DATA WITH DENTAL 4926 03:26:37,520 --> 03:26:40,800 RECORD DATA FOR GREATER RESEARCH 4927 03:26:40,800 --> 03:26:41,360 PURPOSES. 4928 03:26:41,360 --> 03:26:43,440 AND THE NEXT SLIDE IS JUST A 4929 03:26:43,440 --> 03:26:45,600 QUICK PLUG, I KNOW TIME IS 4930 03:26:45,600 --> 03:26:46,120 SHORT. 4931 03:26:46,120 --> 03:26:48,320 ABOUT OUR DATA AND TECHNOLOGY 4932 03:26:48,320 --> 03:26:49,640 ADVANCEMENT NATIONAL DATA 4933 03:26:49,640 --> 03:26:50,080 SCHOLARS PROGRAM. 4934 03:26:50,080 --> 03:26:52,400 IT'S A ONE OR TWO YEAR 4935 03:26:52,400 --> 03:26:54,480 SABBATICAL, RESEARCHERS COME 4936 03:26:54,480 --> 03:26:55,400 FROM ACADEMIA, FROM INDUSTRY, 4937 03:26:55,400 --> 03:26:57,520 THEY ALSO COME FROM OTHER 4938 03:26:57,520 --> 03:26:58,520 FEDERAL AGENCIES, AND FROM 4939 03:26:58,520 --> 03:27:00,720 NON-PROFITS TO WORK ON 4940 03:27:00,720 --> 03:27:02,360 CHALLENGING PROBLEMS, AND THIS 4941 03:27:02,360 --> 03:27:06,640 YEAR WE'LL BE LOOKING AT I 4942 03:27:06,640 --> 03:27:07,680 HEALTH DATA INTEROPERABORITY, 4943 03:27:07,680 --> 03:27:09,040 DATA F PANDEMICS, VERY 4944 03:27:09,040 --> 03:27:10,440 IMPORTANT RIGHT NOW. 4945 03:27:10,440 --> 03:27:12,320 CHALLENGING NEW AREAS AND 4946 03:27:12,320 --> 03:27:15,440 WEARABLES FOR PREDICTING 4947 03:27:15,440 --> 03:27:17,480 CLINICAL OUTCOMES, I'M SURE 4948 03:27:17,480 --> 03:27:23,840 THERE'S INTEGRATION BASED WITH 4949 03:27:23,840 --> 03:27:26,520 DENTAL SPACE, MULTI-MODAL CANCER 4950 03:27:26,520 --> 03:27:28,520 DATA AND ACCELERATED 4951 03:27:28,520 --> 03:27:28,840 PARTNERSHIPS. 4952 03:27:28,840 --> 03:27:30,320 THE APPLICATIONS ARE DUE MAY 27. 4953 03:27:30,320 --> 03:27:33,560 BUT WE RUN THIS EVERY YEAR, IF 4954 03:27:33,560 --> 03:27:36,200 THIS IS NOT THE YEAR FOR YOU. 4955 03:27:36,200 --> 03:27:39,600 LAST SLIDE FOR TODAY IS JUST A 4956 03:27:39,600 --> 03:27:41,040 PLUG THAT EACH MONTH ON THE 4957 03:27:41,040 --> 03:27:43,760 SECOND FRIDAY OF THE MONTH WE 4958 03:27:43,760 --> 03:27:46,840 HIGHLIGHT A DIFFERENT I.C. AND 4959 03:27:46,840 --> 03:27:48,840 THEIR DATA SCIENCE CAPABILITIES 4960 03:27:48,840 --> 03:27:49,680 INCLUDING FUNDING ANNOUNCEMENTS 4961 03:27:49,680 --> 03:27:53,400 AND PROGRAMS, NOT TOO LONG AGO 4962 03:27:53,400 --> 03:27:57,760 WE HIGHLIGHTED THE DENTAL AND 4963 03:27:57,760 --> 03:28:01,480 CRANIOINSTITUTE, DR. YANG CHAI 4964 03:28:01,480 --> 03:28:03,920 TELLING US MORE, INCLUDING A 4965 03:28:03,920 --> 03:28:04,480 VIDEO DEMONSTRATING WORK 4966 03:28:04,480 --> 03:28:06,200 FACEBASE IS DOING. 4967 03:28:06,200 --> 03:28:09,600 WITH THAT, I WANT TO THANK ALL 4968 03:28:09,600 --> 03:28:11,240 OF MY COLLEAGUES AND THE FOLKS 4969 03:28:11,240 --> 03:28:14,960 ACROSS NIH WHO WORK WITH US TO 4970 03:28:14,960 --> 03:28:20,000 DEVELOP AN ENHANCED CLOUD DATA 4971 03:28:20,000 --> 03:28:25,400 INTEGRATING DATA AND CLOUD 4972 03:28:25,400 --> 03:28:26,480 PLATFORMS, ACTIONING A.I., 4973 03:28:26,480 --> 03:28:29,760 ARTIFICIAL INTELLIGENCE, AND 4974 03:28:29,760 --> 03:28:31,080 MACHINE LEARNING WHICH I DIDN'T 4975 03:28:31,080 --> 03:28:32,600 TALK ABOUT TODAY, BUILDING A 4976 03:28:32,600 --> 03:28:34,120 STRONG DIVERSE DATA SCIENCE 4977 03:28:34,120 --> 03:28:34,480 WORKFORCE. 4978 03:28:34,480 --> 03:28:35,960 I'M HAPPY TO TAKE QUESTIONS IF 4979 03:28:35,960 --> 03:28:36,880 THERE'S TIME. 4980 03:28:36,880 --> 03:28:39,920 I CAN ALWAYS BE REACHED AT 4981 03:28:39,920 --> 03:28:40,120 ANYTIME. 4982 03:28:40,120 --> 03:28:41,880 THANK YOU SO MUCH FOR THE 4983 03:28:41,880 --> 03:28:44,880 INVITATION AND CHANCE TO TALK 4984 03:28:44,880 --> 03:28:45,160 TODAY. 4985 03:28:45,160 --> 03:28:46,560 >> THANK YOU, SUSAN. 4986 03:28:46,560 --> 03:28:48,200 THAT SAID, FOLKS SHOULD KNOW 4987 03:28:48,200 --> 03:28:56,280 THAT THE CREATION OF THIS IDEA, 4988 03:28:56,280 --> 03:28:58,200 CONCEPT, HAS GROWN FROM THE 4989 03:28:58,200 --> 03:29:00,120 BRAIN, THE DIRECTOR OF OFFICE OF 4990 03:29:00,120 --> 03:29:00,640 INFORMATION TECHNOLOGY. 4991 03:29:00,640 --> 03:29:03,680 I WANT TO ACKNOWLEDGE JOHN. 4992 03:29:03,680 --> 03:29:05,760 THERE YOU ARE. 4993 03:29:05,760 --> 03:29:06,080 >> HELLO. 4994 03:29:06,080 --> 03:29:07,280 >> YES, THANK YOU FOR YOUR 4995 03:29:07,280 --> 03:29:09,560 VISION AND FOR YOUR LEADERSHIP 4996 03:29:09,560 --> 03:29:13,320 BECAUSE I KNOW YOU SPENT 4997 03:29:13,320 --> 03:29:15,360 COUNTLESS HOURS TO DEVELOP THIS 4998 03:29:15,360 --> 03:29:18,480 INTO A CONCEPT THE WORKING GROUP 4999 03:29:18,480 --> 03:29:20,200 CAN TAKE FORTH. 5000 03:29:20,200 --> 03:29:21,440 >> CERTAINLY. 5001 03:29:21,440 --> 03:29:28,840 IT WAS MY PLEASURE. 5002 03:29:28,840 --> 03:29:30,040 DR. GREGURICK, THANK YOU FOR 5003 03:29:30,040 --> 03:29:31,160 YOUR TIME. 5004 03:29:31,160 --> 03:29:32,040 >> WE'LL BE ATTACHED TO YOU FOR 5005 03:29:32,040 --> 03:29:34,840 QUITE A WHILE NOW. 5006 03:29:34,840 --> 03:29:36,480 >> ABSOLUTELY. 5007 03:29:36,480 --> 03:29:41,200 >> ANY QUESTIONS? 5008 03:29:41,200 --> 03:29:43,480 I HAVE A GLOBAL QUESTION, HOW 5009 03:29:43,480 --> 03:29:45,360 ARE OTHER COUNTRIES DOING? 5010 03:29:45,360 --> 03:29:47,880 THE U.K. FOR EXAMPLE SEEMS TO BE 5011 03:29:47,880 --> 03:29:52,200 A LITTLE BIT FORGING AHEAD WITH 5012 03:29:52,200 --> 03:29:53,840 SOME OF THIS DATABASES. 5013 03:29:53,840 --> 03:29:56,600 IS THAT RIGHT? 5014 03:29:56,600 --> 03:29:58,000 >> THEY ARE. 5015 03:29:58,000 --> 03:30:01,920 WITHIN THE EUROPEAN UNION, 5016 03:30:01,920 --> 03:30:04,040 THERE'S THE ELIXIR PROGRAM THAT 5017 03:30:04,040 --> 03:30:07,280 HAS MAIN DRIVERS IN BIOMEDICAL 5018 03:30:07,280 --> 03:30:09,920 RESEARCH IN LIFE SCIENCE, 5019 03:30:09,920 --> 03:30:11,360 CLIMATE AND THE ENVIRONMENT, AND 5020 03:30:11,360 --> 03:30:13,080 THEIR WORK IS NOT TOO DISSIMILAR 5021 03:30:13,080 --> 03:30:14,560 FROM WORK WE DO. 5022 03:30:14,560 --> 03:30:17,200 THEY RUN ON A DISTRIBUTED HUB 5023 03:30:17,200 --> 03:30:19,200 AND SPOKE MODEL, WHERE THERE ARE 5024 03:30:19,200 --> 03:30:21,120 ELIXIR HUBS, AND THEY ARE MAKING 5025 03:30:21,120 --> 03:30:24,520 GREAT HEADWAY IN ITEMS OF 5026 03:30:24,520 --> 03:30:27,040 INTEGRATING ACROSS THEIR DATA 5027 03:30:27,040 --> 03:30:28,800 SPOKES TO ENABLE FAIR DATA 5028 03:30:28,800 --> 03:30:29,600 SHARING. 5029 03:30:29,600 --> 03:30:37,040 THEY HAVE A LOT OF REALLY 5030 03:30:37,040 --> 03:30:37,680 WORTHWHILE DATA, CREATING PLANS 5031 03:30:37,680 --> 03:30:40,840 WORTH LOOKING AT AS WELL AS DATA 5032 03:30:40,840 --> 03:30:41,200 HARMONIZATION. 5033 03:30:41,200 --> 03:30:43,080 SO I THINK THERE'S BEEN SOME 5034 03:30:43,080 --> 03:30:45,200 REALLY GOOD PROGRESS WITH 5035 03:30:45,200 --> 03:30:45,480 ELIXIR. 5036 03:30:45,480 --> 03:30:47,960 NOW ELIXIR IS ALSO EXPANDING TO 5037 03:30:47,960 --> 03:30:49,400 OTHER COUNTRIES BEYOND THE 5038 03:30:49,400 --> 03:30:51,040 EUROPEAN UNION, AND WE CONNECT 5039 03:30:51,040 --> 03:30:55,280 WITH THEM THROUGH SOME OF OUR 5040 03:30:55,280 --> 03:30:55,960 INTEROPERABILITY ACTIVITIES. 5041 03:30:55,960 --> 03:30:57,600 >> OBVIOUSLY THEY HAVE A 5042 03:30:57,600 --> 03:30:58,920 NATIONAL HEALTH SYSTEM, HEALTH 5043 03:30:58,920 --> 03:31:01,000 CARE SYSTEM, SO THAT MUST HELP 5044 03:31:01,000 --> 03:31:05,040 IN TERMS OF PATIENT RECORDS AND 5045 03:31:05,040 --> 03:31:06,040 SYSTEMIC CONNECTIONS AS WELL, 5046 03:31:06,040 --> 03:31:06,400 RIGHT? 5047 03:31:06,400 --> 03:31:07,240 I WOULD IMAGINE. 5048 03:31:07,240 --> 03:31:08,760 >> I THINK IT DOES. 5049 03:31:08,760 --> 03:31:10,560 THEY DO HAVE SOME DATA SHARING 5050 03:31:10,560 --> 03:31:12,000 REQUIREMENTS THAT MIGHT BE A 5051 03:31:12,000 --> 03:31:13,600 LITTLE BIT HIGHER BAR THAN SOME 5052 03:31:13,600 --> 03:31:17,520 OF THE WORK THAT WE DO HERE BUT 5053 03:31:17,520 --> 03:31:18,880 INDEED THEIR HARMONIZATION OF 5054 03:31:18,880 --> 03:31:20,280 ELECTRONIC HEALTH CARE RECORDS 5055 03:31:20,280 --> 03:31:22,760 IS QUITE MORE ADVANCED THAN WHAT 5056 03:31:22,760 --> 03:31:25,240 WE DO, ALTHOUGH FHIR IS AN 5057 03:31:25,240 --> 03:31:27,800 INCREDIBLY GOOD TOOL HERE. 5058 03:31:27,800 --> 03:31:29,240 BUT THEIR NATIONAL HEALTH CARE 5059 03:31:29,240 --> 03:31:32,920 SYSTEM DOES ALLOW FOR GREATER 5060 03:31:32,920 --> 03:31:33,400 HARMONIZATION. 5061 03:31:33,400 --> 03:31:38,000 >> YES. 5062 03:31:38,000 --> 03:31:41,600 AXEL, I KNOW YOU PROBABLY HAVE 5063 03:31:41,600 --> 03:31:44,720 QUITE AN INTEREST AND ALSO SOME 5064 03:31:44,720 --> 03:31:47,640 SKILLS IN THIS AREA. 5065 03:31:47,640 --> 03:31:49,600 DO YOU HAVE ANYTHING TO BRING 5066 03:31:49,600 --> 03:31:50,320 UP? 5067 03:31:50,320 --> 03:31:54,160 >> SO, FIRST OF ALL, THANK YOU. 5068 03:31:54,160 --> 03:31:56,280 THIS WAS A GREAT PRESENTATION 5069 03:31:56,280 --> 03:31:58,240 WITH A LOT OF INTERESTING 5070 03:31:58,240 --> 03:32:01,040 THOUGHTS AND BACKGROUND FOR OUR 5071 03:32:01,040 --> 03:32:03,560 DATA SCIENCE WORKING GROUP. 5072 03:32:03,560 --> 03:32:05,480 SOMETHING THAT WE WILL DO IN THE 5073 03:32:05,480 --> 03:32:10,000 NEXT FEW WEEKS IS GET TOGETHER 5074 03:32:10,000 --> 03:32:11,800 AND THINK ABOUT THE EXACT CHARGE 5075 03:32:11,800 --> 03:32:13,800 FOR THIS WORKING GROUP, THE 5076 03:32:13,800 --> 03:32:15,640 GOALS, AND THEN OBVIOUSLY 5077 03:32:15,640 --> 03:32:16,640 CONSIDERING THE COMPLEXITY OF 5078 03:32:16,640 --> 03:32:19,280 ALL OF THIS, ALSO HAVE TO THINK 5079 03:32:19,280 --> 03:32:23,240 ABOUT BOUNDARIES OF WHAT WE'RE 5080 03:32:23,240 --> 03:32:25,760 TRYING TO ACCOMPLISH HERE. 5081 03:32:25,760 --> 03:32:27,480 AND I ASSUME WE CAN PROBABLY 5082 03:32:27,480 --> 03:32:31,840 ALSO GET A COPY OF THESE SLIDES 5083 03:32:31,840 --> 03:32:33,720 TO LOOK AT IN DETAIL AND TALK 5084 03:32:33,720 --> 03:32:33,920 THROUGH 5085 03:32:33,920 --> 03:32:35,160 >> YES. 5086 03:32:35,160 --> 03:32:38,600 >> I PUT IT IN THE CHAT EARLIER, 5087 03:32:38,600 --> 03:32:40,360 WE'RE STILL LOOKING FOR PEOPLE 5088 03:32:40,360 --> 03:32:42,400 WHO WANT TO PARTICIPATE IN THIS 5089 03:32:42,400 --> 03:32:44,680 WORKING GROUP, SO WHOEVER IS 5090 03:32:44,680 --> 03:32:47,400 INTERESTED SHOULD PLEASE GET IN 5091 03:32:47,400 --> 03:32:53,320 CONTACT, GET IN TOUCH WITH ME OR 5092 03:32:53,320 --> 03:32:57,480 I GUESS LYNN OR LIU WANG, WE'LL 5093 03:32:57,480 --> 03:32:58,480 PUT THIS TOGETHER. 5094 03:32:58,480 --> 03:33:00,320 SOMETHING THAT WAS CLEAR FROM 5095 03:33:00,320 --> 03:33:04,840 THE PRESENTATION JUST NOW IS HOW 5096 03:33:04,840 --> 03:33:07,760 MANY AREAS OF NIDCR'S WORK THIS 5097 03:33:07,760 --> 03:33:13,040 POTENTIALLY TOUCHES, ALL THE WAY 5098 03:33:13,040 --> 03:33:14,800 FROM THE BASIC SCIENCE AND 5099 03:33:14,800 --> 03:33:17,320 ACTUAL DATA SCIENCE EFFORTS LIKE 5100 03:33:17,320 --> 03:33:19,400 MAKING DATA ACCESSIBLE AND SO ON 5101 03:33:19,400 --> 03:33:21,160 BUT ALSO LIKE POTENTIALLY 5102 03:33:21,160 --> 03:33:23,640 EXTENDING ALL THE WAY INTO 5103 03:33:23,640 --> 03:33:24,440 CLINICAL PRACTICE. 5104 03:33:24,440 --> 03:33:28,480 SO, WITH THAT IN MIND I WOULD 5105 03:33:28,480 --> 03:33:34,280 HOPE THAT WE WILL HAVE A DIVERSE 5106 03:33:34,280 --> 03:33:36,120 REPRESENTATION FROM DIFFERENT 5107 03:33:36,120 --> 03:33:38,960 ASPECTS OF NIDCR'S WORK, NOT 5108 03:33:38,960 --> 03:33:41,960 JUST PEOPLE WHO HAVE INHERENT 5109 03:33:41,960 --> 03:33:42,960 INTEREST IN BIOINFORMATICS OR 5110 03:33:42,960 --> 03:33:43,840 ARE KNOWLEDGEABLE BUT ALSO 5111 03:33:43,840 --> 03:33:48,160 PEOPLE WHO FEEL LIKE THERE COULD 5112 03:33:48,160 --> 03:33:50,000 BE WAYS TO LEVERAGE DATA SCIENCE 5113 03:33:50,000 --> 03:33:51,360 IN THEIR RESPECTIVE FIELD. 5114 03:33:51,360 --> 03:33:53,560 SO WITH THAT IN MIND I WOULD 5115 03:33:53,560 --> 03:33:56,000 ENCOURAGE PEOPLE WHO FEEL LIKE 5116 03:33:56,000 --> 03:33:57,720 THEY ARE NOT PERHAPS -- NOT 5117 03:33:57,720 --> 03:33:59,560 SUPER KNOWLEDGEABLE IN DATA 5118 03:33:59,560 --> 03:34:01,080 SCIENCE PER SE TO CONSIDER 5119 03:34:01,080 --> 03:34:03,520 PARTICIPATING IN THE WORKING 5120 03:34:03,520 --> 03:34:07,560 GROUP SO WE CAN UNDERSTAND WHAT 5121 03:34:07,560 --> 03:34:10,160 THE NEEDS ARE, AND THEN THINK 5122 03:34:10,160 --> 03:34:13,040 ABOUT HOW COULD THIS TRANSLATE 5123 03:34:13,040 --> 03:34:14,240 INTO ACTIONS OR RECOMMENDATIONS 5124 03:34:14,240 --> 03:34:16,960 THAT THE WORKING GROUP MIGHT 5125 03:34:16,960 --> 03:34:17,400 MAKE. 5126 03:34:17,400 --> 03:34:20,360 >> YES. 5127 03:34:20,360 --> 03:34:22,800 AND JUST SO YOU KNOW, A REAL 5128 03:34:22,800 --> 03:34:27,040 THOUGHT LEADER IN THE FIELD OF 5129 03:34:27,040 --> 03:34:28,240 DENTAL DATA SCIENCE WAS 5130 03:34:28,240 --> 03:34:29,800 RECOMMENDED BY PATTI BRENNAN, 5131 03:34:29,800 --> 03:34:38,120 HEAD OF NATIONAL LIBRARY OF 5132 03:34:38,120 --> 03:34:40,080 MEDICINE, WE'LL MAKE SURE WE DO 5133 03:34:40,080 --> 03:34:47,920 OF DO THAT DILIGENCE TO GIVE YOU 5134 03:34:47,920 --> 03:34:49,000 A LIST OF POSSIBILITIES. 5135 03:34:49,000 --> 03:34:51,560 YOU HAVE YOUR HAND UP. 5136 03:34:51,560 --> 03:34:55,760 THANK YOU FOR WORKING ON THIS AS 5137 03:34:55,760 --> 03:34:55,960 WELL. 5138 03:34:55,960 --> 03:34:56,600 >> THANK YOU. 5139 03:34:56,600 --> 03:34:57,600 THANK YOU, RENA. 5140 03:34:57,600 --> 03:35:00,360 I'LL LOWER MY HAND BEFORE I 5141 03:35:00,360 --> 03:35:00,680 TALK. 5142 03:35:00,680 --> 03:35:04,200 SUSAN, THANKS FOR THE WONDERFUL 5143 03:35:04,200 --> 03:35:04,640 TALK. 5144 03:35:04,640 --> 03:35:09,960 I ALWAYS TELL MY COLLEAGUES, I 5145 03:35:09,960 --> 03:35:13,040 AFTER MANY SEMINARS THAT I 5146 03:35:13,040 --> 03:35:15,680 ATTEND, THE SEMINARS OFFERED BY 5147 03:35:15,680 --> 03:35:17,080 YOUR OFFICE OTHERWISE I WILL 5148 03:35:17,080 --> 03:35:19,920 ALWAYS TRY MY BEST TO ATTEND 5149 03:35:19,920 --> 03:35:22,240 BECAUSE I ALWAYS LEARN SO MUCH 5150 03:35:22,240 --> 03:35:24,280 AND I HAVE THE FULL FRONT OF 5151 03:35:24,280 --> 03:35:25,760 DATA SCIENCE. 5152 03:35:25,760 --> 03:35:28,360 THANK YOU FOR THAT. 5153 03:35:28,360 --> 03:35:31,600 MY QUESTION REALLY HAS TO DO 5154 03:35:31,600 --> 03:35:34,200 WITH WHAT DO WE ANTICIPATE IN 5155 03:35:34,200 --> 03:35:39,120 THE ARENA OF DATA SCIENCE WHEN 5156 03:35:39,120 --> 03:35:41,120 SCIENCE AND TECHNOLOGIES 5157 03:35:41,120 --> 03:35:43,760 CONTINUE TO ADVANCE RAPIDLY, SO 5158 03:35:43,760 --> 03:35:47,040 WE WILL CONTINUE TO HAVE THE 5159 03:35:47,040 --> 03:35:49,680 EXPLOSION OF BIG DATA, IN 5160 03:35:49,680 --> 03:35:52,080 MULTI-DIMENSIONS, AND AT THE 5161 03:35:52,080 --> 03:35:56,240 SAME TIME WE WILL HAVE NEW AND 5162 03:35:56,240 --> 03:35:58,840 FOR SURE NEW TECHNOLOGY 5163 03:35:58,840 --> 03:36:00,560 PLATFORMS THAT WILL PRODUCE NEW 5164 03:36:00,560 --> 03:36:04,320 DATA TYPES THAT WE MIGHT NOT BE 5165 03:36:04,320 --> 03:36:08,000 ABLE EVEN TO ANTICIPATE AT THIS 5166 03:36:08,000 --> 03:36:08,400 POINT. 5167 03:36:08,400 --> 03:36:11,000 THAT IS WHEN DISRUPTION OF 5168 03:36:11,000 --> 03:36:13,640 TECHNOLOGY, YOU KNOW, REALLY 5169 03:36:13,640 --> 03:36:19,080 COMES INTO THE REAL WORLD, IN 5170 03:36:19,080 --> 03:36:22,920 OUR INVESTIGATORS' RESEARCH. 5171 03:36:22,920 --> 03:36:25,760 I'M JUST WONDERING ABOUT WHAT 5172 03:36:25,760 --> 03:36:29,160 MAY BE CONSIDERED AS VERY 5173 03:36:29,160 --> 03:36:30,280 COMPREHENSIVE AND COMPLETE 5174 03:36:30,280 --> 03:36:33,800 DATASETS, IN LET'S SAY FIVE 5175 03:36:33,800 --> 03:36:35,560 YEARS, BE REGARDED AS 5176 03:36:35,560 --> 03:36:40,480 INCOMPLETE, YOU KNOW, AS NOT 5177 03:36:40,480 --> 03:36:42,240 COMPREHENSIVE ENOUGH, SO IN THAT 5178 03:36:42,240 --> 03:36:44,320 REGARD I HAVE BEEN WONDERING A 5179 03:36:44,320 --> 03:36:49,360 LOT ABOUT WHAT COULD BE DONE TO 5180 03:36:49,360 --> 03:36:51,240 REALLY -- TOWARDS THE 5181 03:36:51,240 --> 03:36:53,760 DEVELOPMENT OF MORE ADVANCED 5182 03:36:53,760 --> 03:36:57,760 DATA ANALYTICS THAT CAN HANDLE 5183 03:36:57,760 --> 03:37:01,840 WHAT MAY BE VIEWED AS COMPLETE 5184 03:37:01,840 --> 03:37:02,760 DATASET OR INCOMPLETE DATASET, 5185 03:37:02,760 --> 03:37:04,480 THIS IS REALLY, YOU KNOW, 5186 03:37:04,480 --> 03:37:07,440 SOMETHING I WONDER A LOT IN 5187 03:37:07,440 --> 03:37:09,200 TERMS OF WHAT FUTURE -- 5188 03:37:09,200 --> 03:37:13,280 >> CAN YOU ADDRESS THAT PLEASE? 5189 03:37:13,280 --> 03:37:13,800 >> ABSOLUTELY. 5190 03:37:13,800 --> 03:37:15,600 SO GLAD YOU ASKED THAT. 5191 03:37:15,600 --> 03:37:17,040 FIRST, THE STRATEGIC PLAN FOR 5192 03:37:17,040 --> 03:37:21,520 DATA SCIENCE WHICH I HIGHLIGHTED 5193 03:37:21,520 --> 03:37:25,600 IS 2018 TO 2022, YOU CAN IMAGINE 5194 03:37:25,600 --> 03:37:27,560 WE'VE BEEN STARTING THE INITIAL 5195 03:37:27,560 --> 03:37:30,600 PROCESS FOR THE STRATEGIC PLAN 5196 03:37:30,600 --> 03:37:36,080 FOR DATA SCIENCE FOR 2023 TO 5197 03:37:36,080 --> 03:37:36,400 2028. 5198 03:37:36,400 --> 03:37:36,960 FIVE-YEAR PLAN. 5199 03:37:36,960 --> 03:37:39,480 AND SOME OF THE THINGS WE'LL BE 5200 03:37:39,480 --> 03:37:41,120 LOOKING AT DO START TO ADDRESS 5201 03:37:41,120 --> 03:37:42,400 WHAT YOU'RE SPEAKING OF, DR. 5202 03:37:42,400 --> 03:37:46,240 WANG, IN TERMS OF LOOKING AT 5203 03:37:46,240 --> 03:37:47,360 DATA AS THE PRIMARY 5204 03:37:47,360 --> 03:37:48,440 INFRASTRUCTURE SO THERE'S A LOT 5205 03:37:48,440 --> 03:37:51,840 GOING ON IN INDUSTRY AROUND THE 5206 03:37:51,840 --> 03:37:53,880 CONCEPT OF DATA MESH OR 5207 03:37:53,880 --> 03:37:54,960 HARMONIZING DATA INFRASTRUCTURE 5208 03:37:54,960 --> 03:37:56,840 SO THAT IT IS INTERCONNECTED IN 5209 03:37:56,840 --> 03:37:59,040 WAYS THAT MAKE SENSE FOR THE 5210 03:37:59,040 --> 03:37:59,320 DATA. 5211 03:37:59,320 --> 03:38:01,920 AND THIS WILL BE SOMETHING THAT 5212 03:38:01,920 --> 03:38:04,480 YOU'LL SEE, BUT ALSO IN 5213 03:38:04,480 --> 03:38:07,600 IMPROVING OUR DATA COMPUTATION 5214 03:38:07,600 --> 03:38:11,560 AND ALGORITHMS, THIS COULD 5215 03:38:11,560 --> 03:38:12,880 INCLUDE COMPUTING ACROSS, ALSO 5216 03:38:12,880 --> 03:38:16,360 CREATING A.I. AND ETHICAL 5217 03:38:16,360 --> 03:38:17,320 FRAMEWORKS AS WELL AS 5218 03:38:17,320 --> 03:38:19,200 UNDERSTANDING COMPLETENESS OF 5219 03:38:19,200 --> 03:38:20,800 DATA BY UTILIZING A.I. 5220 03:38:20,800 --> 03:38:23,000 OFTENTIMES WE HAVE TO THINK 5221 03:38:23,000 --> 03:38:26,920 ABOUT A.I. EITHER AS A FEDERATED 5222 03:38:26,920 --> 03:38:28,240 LEARNING OR AS ITERATIVE MODEL 5223 03:38:28,240 --> 03:38:31,520 FOR LEARNING SO YOU'LL SEE A LOT 5224 03:38:31,520 --> 03:38:34,080 MORE IN TERMS OF A.I. 5225 03:38:34,080 --> 03:38:35,480 INFRASTRUCTURE AND INTEGRATION 5226 03:38:35,480 --> 03:38:37,480 OF A.I. ETHICS BIAS 5227 03:38:37,480 --> 03:38:39,320 TRANSPARENCY, AS WELL AS NEW 5228 03:38:39,320 --> 03:38:40,600 IDEAS AND SOCIAL DETERMINANTS OF 5229 03:38:40,600 --> 03:38:42,560 HEALTH AND REAL WORLD DATA WHICH 5230 03:38:42,560 --> 03:38:44,000 DOES ADD AN ADDITIONAL COMPONENT 5231 03:38:44,000 --> 03:38:45,800 AND I THINK THERE'S PROBABLY 5232 03:38:45,800 --> 03:38:51,800 SOME VERY INTERESTING IDEAS OF 5233 03:38:51,800 --> 03:38:52,840 INTEGRATING DENTAL DATA 5234 03:38:52,840 --> 03:38:53,960 TOGETHER, SOMETHING I'M NOT SURE 5235 03:38:53,960 --> 03:38:55,040 THE EXTENT HAPPENING NOW BUT 5236 03:38:55,040 --> 03:38:56,520 COULD BE AN IMPORTANT COMPONENT 5237 03:38:56,520 --> 03:38:58,680 IN FIVE YEARS BUT UNDERSTANDING 5238 03:38:58,680 --> 03:38:59,360 THE COMPLETENESS OF THE DATA 5239 03:38:59,360 --> 03:39:01,520 WHICH IS WHAT YOU'RE SPEAKING 5240 03:39:01,520 --> 03:39:04,080 OF, COMPUTING ON DATA THAT'S AT 5241 03:39:04,080 --> 03:39:05,120 THE PETABYTE SCALE, TWO GRAND 5242 03:39:05,120 --> 03:39:06,440 CHALLENGES THAT I SEE GOING 5243 03:39:06,440 --> 03:39:08,320 AHEAD COULD BE OF GREAT INTEREST 5244 03:39:08,320 --> 03:39:10,400 TO OUR SCIENTIFIC COMMUNITY AND 5245 03:39:10,400 --> 03:39:12,040 TO THE SCIENTIFIC COMMUNITY WRIT 5246 03:39:12,040 --> 03:39:13,320 LARGE FUNDED BY NSF AND 5247 03:39:13,320 --> 03:39:16,560 DEPARTMENT OF ENERGY. 5248 03:39:16,560 --> 03:39:21,600 >> A FOLLOW-UP QUESTION, IS 5249 03:39:21,600 --> 03:39:22,600 THERE TIME? 5250 03:39:22,600 --> 03:39:24,400 >> THIS IS SUCH A WORTHY 5251 03:39:24,400 --> 03:39:27,600 DISCUSSION, I THINK WE HAVE 5252 03:39:27,600 --> 03:39:32,200 TIME, RIGHT, LYNN? 5253 03:39:32,200 --> 03:39:33,800 2:00 IS WHEN DENA COMES ON. 5254 03:39:33,800 --> 03:39:37,560 >> WE HAVE TIME FOR ANOTHER 5255 03:39:37,560 --> 03:39:38,400 QUESTION. 5256 03:39:38,400 --> 03:39:41,600 >> AND WHAT YOU'RE SAYING IS SO 5257 03:39:41,600 --> 03:39:45,200 RELEVANT AND APPLIES TO BEST 5258 03:39:45,200 --> 03:39:47,160 PRACTICES, IF YOU'RE A SURGEON 5259 03:39:47,160 --> 03:39:48,840 AND DECIDED TO INTERVENE FOR 5260 03:39:48,840 --> 03:39:49,920 CORRECTION LATER THAN MOST 5261 03:39:49,920 --> 03:39:54,080 PRESCRIBED AND HAVE THIS DATA 5262 03:39:54,080 --> 03:39:58,400 THAT SAYS DOING MUCH BETTER 5263 03:39:58,400 --> 03:39:59,240 BECAUSE OF INTERVENTION, THE 5264 03:39:59,240 --> 03:40:01,440 CHILD DID WELL, HOW DO YOU GET 5265 03:40:01,440 --> 03:40:03,720 THAT ACROSS, HOW DOES ONE HANDLE 5266 03:40:03,720 --> 03:40:04,640 MISINFORMATION AND 5267 03:40:04,640 --> 03:40:05,440 MISINTERPRETATION OF DATA? 5268 03:40:05,440 --> 03:40:07,240 ALL OF THOSE QUESTIONS ARE GOING 5269 03:40:07,240 --> 03:40:17,760 TO BE REALLY CONFOUNDING FOR US. 5270 03:40:22,400 --> 03:40:23,200 >> THANK YOU. 5271 03:40:23,200 --> 03:40:24,600 CLARK? 5272 03:40:24,600 --> 03:40:27,520 >> FOR THE RESEARCH COMMUNITY, I 5273 03:40:27,520 --> 03:40:29,840 WANT TO UNDERSTAND NUANCES, MANY 5274 03:40:29,840 --> 03:40:31,240 TIMES WE WILL COLLECT FOR 5275 03:40:31,240 --> 03:40:35,080 INSTANCE A RANGE OF DIFFERENT 5276 03:40:35,080 --> 03:40:36,680 DATASETS COMING OFF BIOSAMPLES 5277 03:40:36,680 --> 03:40:39,440 BUT THE REPOSITORY OF THE 5278 03:40:39,440 --> 03:40:40,240 BIOSAMPLES, THE DATA YOU'RE 5279 03:40:40,240 --> 03:40:42,200 GETTING IS ONLY AS GOOD AS 5280 03:40:42,200 --> 03:40:43,640 MEASUREMENT TECHNIQUES THAT WERE 5281 03:40:43,640 --> 03:40:44,480 DONE BY THAT INVESTIGATOR, 5282 03:40:44,480 --> 03:40:47,400 THAT'S THE DATA BEING SHARED IN 5283 03:40:47,400 --> 03:40:48,800 THESE DATASETS, IS THERE 5284 03:40:48,800 --> 03:40:51,520 THOUGHTS HOW TO COMMUNICATE WITH 5285 03:40:51,520 --> 03:40:54,920 THE INVESTIGATIVE COMMUNITY AS 5286 03:40:54,920 --> 03:41:00,280 TO HOW TO MAKE THE ORIGINAL 5287 03:41:00,280 --> 03:41:01,560 BIOSPECIMEN AVAILABLE FOR 5288 03:41:01,560 --> 03:41:02,880 TECHNIQUES OR REPLICATION OF 5289 03:41:02,880 --> 03:41:03,640 MEASUREMENT APPROACHES? 5290 03:41:03,640 --> 03:41:08,440 AND HAS THAT BEEN THOUGHT ABOUT 5291 03:41:08,440 --> 03:41:10,640 OR HOW TO COMMUNICATE THAT, OR 5292 03:41:10,640 --> 03:41:12,080 NOT, WITH THE RESEARCH 5293 03:41:12,080 --> 03:41:12,520 COMMUNITY? 5294 03:41:12,520 --> 03:41:13,400 THAT'S ALL. 5295 03:41:13,400 --> 03:41:15,160 THANK YOU. 5296 03:41:15,160 --> 03:41:15,640 EXCELLENT PRESENTATION. 5297 03:41:15,640 --> 03:41:16,560 >> THANK YOU. 5298 03:41:16,560 --> 03:41:19,880 THANK YOU SO MUCH, DR. STANFORD. 5299 03:41:19,880 --> 03:41:21,880 THAT'S A GREAT QUESTION. 5300 03:41:21,880 --> 03:41:23,880 I HAVE SEEN IT EMERGING BOTH 5301 03:41:23,880 --> 03:41:25,720 THROUGH NCBI AND THE WORK THAT 5302 03:41:25,720 --> 03:41:26,920 WE'RE DOING IN COLLECTING 5303 03:41:26,920 --> 03:41:29,480 GENOMICS DATA AND ALSO 5304 03:41:29,480 --> 03:41:31,200 BIOSPECIMEN DATA, LINKING THOSE 5305 03:41:31,200 --> 03:41:34,360 DATA IN THE GENOMICS SPHERE WITH 5306 03:41:34,360 --> 03:41:36,040 THE ACTUAL REPOSITORY SAMPLES. 5307 03:41:36,040 --> 03:41:37,240 THIS IS CERTAINLY PLAYING OUT 5308 03:41:37,240 --> 03:41:39,400 ALSO IN OUR COVID WORK, 5309 03:41:39,400 --> 03:41:42,480 ESPECIALLY IN OUR RECOVER, WHERE 5310 03:41:42,480 --> 03:41:44,640 WE FUNDED CLINICAL SCIENCE CORE 5311 03:41:44,640 --> 03:41:46,840 FOR THE CLINICAL STUDIES, 5312 03:41:46,840 --> 03:41:49,280 BIODATA REPOSITORY CORE FOR 5313 03:41:49,280 --> 03:41:51,160 SAMPLES, AND DATA RESOURCE CORE, 5314 03:41:51,160 --> 03:41:52,880 ALL THREE LINK TOGETHER, LINK 5315 03:41:52,880 --> 03:41:55,280 SAMPLES WITH THE DATA, WITH THE 5316 03:41:55,280 --> 03:41:55,680 CLINICAL STUDIES. 5317 03:41:55,680 --> 03:41:59,320 I THINK THAT HOPEFULLY WE'LL SEE 5318 03:41:59,320 --> 03:42:02,280 THIS EMERGING AS A COMPONENT 5319 03:42:02,280 --> 03:42:03,840 THAT'S MUCH MORE INSTANTIATED 5320 03:42:03,840 --> 03:42:06,120 HERE AT NIH BECAUSE YOU'RE 5321 03:42:06,120 --> 03:42:09,280 RIGHT, THE SAMPLES HOLD ALSO 5322 03:42:09,280 --> 03:42:10,360 FUTURE ANALYSIS CAPABILITIES, 5323 03:42:10,360 --> 03:42:12,800 AND IT'S A PERFECT EXAMPLE OF 5324 03:42:12,800 --> 03:42:15,600 MICROARRAY DATA THAT'S NOW BEEN 5325 03:42:15,600 --> 03:42:17,280 REPLACED WITH RNAseq, HAVING 5326 03:42:17,280 --> 03:42:18,400 THOSE ORIGINAL SAMPLES ENABLES 5327 03:42:18,400 --> 03:42:21,640 YOU TO GO BACK TO BETTER AND 5328 03:42:21,640 --> 03:42:22,840 MORE IN DEPTH TECHNOLOGY. 5329 03:42:22,840 --> 03:42:23,920 >> YES. 5330 03:42:23,920 --> 03:42:26,880 AND JENNIFER MENTIONED THAT 5331 03:42:26,880 --> 03:42:29,480 WE'VE DISCUSSED QUITE 5332 03:42:29,480 --> 03:42:33,120 EXTENSIVELY THE IMPORTANCE OF 5333 03:42:33,120 --> 03:42:33,880 STANDARDIZING DATA SELECTION 5334 03:42:33,880 --> 03:42:35,400 ACROSS NIDCR STUDIES. 5335 03:42:35,400 --> 03:42:40,480 THAT ITSELF IS A GOING TO BE -- 5336 03:42:40,480 --> 03:42:40,760 YEAH. 5337 03:42:40,760 --> 03:42:42,120 AXEL, YOU WANT TO SAY SOMETHING? 5338 03:42:42,120 --> 03:42:44,120 >> I HAD THE EXACT SAME THOUGHT 5339 03:42:44,120 --> 03:42:45,400 JENNIFER PUT IN THERE. 5340 03:42:45,400 --> 03:42:48,240 AND JUST WANTED TO ADD TO THE 5341 03:42:48,240 --> 03:42:51,840 POINT WHICH IS MADE WHICH IS 5342 03:42:51,840 --> 03:42:54,680 THAT, YOU KNOW, YES, THE DATA IS 5343 03:42:54,680 --> 03:42:57,200 ONLY AS GOOD AS THE MEASUREMENTS 5344 03:42:57,200 --> 03:42:59,760 THAT YOU MAKE, THE TECHNIQUE, 5345 03:42:59,760 --> 03:43:02,040 BUT WHEN YOU THINK ABOUT USING 5346 03:43:02,040 --> 03:43:04,360 THIS IN DATA SCIENCE APPLICATION 5347 03:43:04,360 --> 03:43:04,960 THERE'S ANOTHER IMPORTANT 5348 03:43:04,960 --> 03:43:09,040 COMPONENT WHICH IS THAT EVEN THE 5349 03:43:09,040 --> 03:43:11,160 MOST ACCURATE MEASUREMENTS, 5350 03:43:11,160 --> 03:43:14,200 HIGHEST QUALITY DATA, IS FAIRLY 5351 03:43:14,200 --> 03:43:17,400 USELESS IF YOU DON'T HAVE 5352 03:43:17,400 --> 03:43:27,640 STANDARDS, AND IT'S IMPORTANT TO 5353 03:43:27,640 --> 03:43:28,520 STANDARDIZE DATA. 5354 03:43:28,520 --> 03:43:31,600 FOR DATA MAN REALLY PROCESSED IN 5355 03:43:31,600 --> 03:43:34,800 THE PAST, DON'T EVEN EXIST, SO 5356 03:43:34,800 --> 03:43:36,840 WHEN WE THINK ABOUT MICROARRAYS, 5357 03:43:36,840 --> 03:43:40,320 IT TOOK A LONG TIME TO EVEN COME 5358 03:43:40,320 --> 03:43:43,400 UP WITH AN AGREED UPON SET OF 5359 03:43:43,400 --> 03:43:45,040 METADATA STANDARDS FOR THESE 5360 03:43:45,040 --> 03:43:47,480 KINDS OF EXPERIMENTS, THE 5361 03:43:47,480 --> 03:43:51,880 COMMUNITY AGREED ON, REQUIRED 5362 03:43:51,880 --> 03:43:53,360 FOR DEPOSITING THAT DATA. 5363 03:43:53,360 --> 03:43:55,560 I'VE BEEN INVOLVED IN FACEBASE 5364 03:43:55,560 --> 03:43:59,400 FOR THE LAST DECADE OR SO AND WE 5365 03:43:59,400 --> 03:44:02,440 SEES THE SAME THING, MANY KINDS 5366 03:44:02,440 --> 03:44:04,920 OF DATA IN THERE THAT ARE 5367 03:44:04,920 --> 03:44:08,880 ONE-OFF FROM -- THEY ARE NOT 5368 03:44:08,880 --> 03:44:10,440 STANDARD SEQUENCE DATA, THESE 5369 03:44:10,440 --> 03:44:14,480 ARE DATA TYPES THAT ARE NOVEL 5370 03:44:14,480 --> 03:44:16,440 AND NO DATA STANDARD EXISTS. 5371 03:44:16,440 --> 03:44:18,640 I WOULD HOPE THAT AS PART OF OUR 5372 03:44:18,640 --> 03:44:20,160 DATA SCIENCE WORKING GROUP THAT 5373 03:44:20,160 --> 03:44:23,000 WILL BE AN IMPORTANT COMPONENT 5374 03:44:23,000 --> 03:44:27,400 TO THINK ABOUT WAYS HOW NIDCR 5375 03:44:27,400 --> 03:44:31,800 CAN POTENTIALLY PLAY A ROLE IN 5376 03:44:31,800 --> 03:44:33,320 DEFINING DATA STANDARDS AND IN 5377 03:44:33,320 --> 03:44:34,400 PARTICULAR BECAUSE I ASSUME 5378 03:44:34,400 --> 03:44:37,320 THERE ARE MANY DATA TYPES THAT 5379 03:44:37,320 --> 03:44:40,280 ARE VERY SPECIFIC TO THE KIND OF 5380 03:44:40,280 --> 03:44:42,400 RESEARCH THAT IS DONE BY NIDCR, 5381 03:44:42,400 --> 03:44:46,480 NOT BY ANY OF THE OTHER I.C.s. 5382 03:44:46,480 --> 03:44:48,960 AND WHERE NO SUCH DATA STANDARDS 5383 03:44:48,960 --> 03:44:49,280 EXIST. 5384 03:44:49,280 --> 03:44:51,520 SO I THINK THIS SHOULD PROBABLY 5385 03:44:51,520 --> 03:44:53,680 BE AN IMPORTANT PART OF THE 5386 03:44:53,680 --> 03:44:55,000 CHARGE OF THIS WORKING GROUP TO, 5387 03:44:55,000 --> 03:44:56,480 AT LEAST PROVIDE A FRAMEWORK HOW 5388 03:44:56,480 --> 03:44:59,800 WE MIGHT GET TO THE POINT OF 5389 03:44:59,800 --> 03:45:02,480 HAVING SUCH STANDARDS. 5390 03:45:02,480 --> 03:45:10,520 >> ABSOLUTELY. 5391 03:45:10,520 --> 03:45:12,640 5392 03:45:12,640 --> 03:45:16,520 >> LU, DO YOU WANT TO PICK UP? 5393 03:45:16,520 --> 03:45:18,280 >> I WILL. 5394 03:45:18,280 --> 03:45:18,760 QUICKLY. 5395 03:45:18,760 --> 03:45:20,520 THANK YOU, RENA. 5396 03:45:20,520 --> 03:45:23,360 SUSAN, THE NEXT QUESTION HAS TO 5397 03:45:23,360 --> 03:45:26,640 DO WITH WHAT I UNDERSTAND TO BE 5398 03:45:26,640 --> 03:45:29,360 THE SITUATION WITH THE MAJOR 5399 03:45:29,360 --> 03:45:30,400 CLOUD PLATFORM VENDORS. 5400 03:45:30,400 --> 03:45:36,240 AND, YOU KNOW, WE HEAR FROM OUR 5401 03:45:36,240 --> 03:45:37,800 INVESTIGATORS THAT THE VENDORS 5402 03:45:37,800 --> 03:45:40,080 DON'T, YOU KNOW, COLLABORATE 5403 03:45:40,080 --> 03:45:41,440 THAT WELL. 5404 03:45:41,440 --> 03:45:43,760 SO THERE'S A REALISTIC SITUATION 5405 03:45:43,760 --> 03:45:46,040 THAT WE AS PROGRAM STAFF HAVE TO 5406 03:45:46,040 --> 03:45:50,520 FACE WHEN WE TRY TO FACILITATE 5407 03:45:50,520 --> 03:45:52,480 OUR INVESTIGATORS AS TO, YOU 5408 03:45:52,480 --> 03:45:56,640 KNOW, WHAT TO CHOOSE THROUGH OUR 5409 03:45:56,640 --> 03:45:57,320 STRIDES INITIATIVE. 5410 03:45:57,320 --> 03:46:02,280 AND COULD YOU PLEASE OFFER ANY 5411 03:46:02,280 --> 03:46:07,240 INSIGHT ON THE FUTURE USAGE OF 5412 03:46:07,240 --> 03:46:10,920 THESE MAJOR CLOUD PLATFORMS 5413 03:46:10,920 --> 03:46:14,160 THROUGH THE STRIDES PROGRAM? 5414 03:46:14,160 --> 03:46:15,120 >> ABSOLUTELY, SOMETHING OF 5415 03:46:15,120 --> 03:46:17,200 GREAT INTEREST TO MYSELF, ALSO 5416 03:46:17,200 --> 03:46:20,800 TO ANDREA NORRIS, OUR CHIEF 5417 03:46:20,800 --> 03:46:22,080 INFORMATION OFFICER. 5418 03:46:22,080 --> 03:46:25,320 MY COLLEAGUES AT CIT AND STRIDES 5419 03:46:25,320 --> 03:46:27,720 PROGRAM, AND THE INSTITUTES AS 5420 03:46:27,720 --> 03:46:29,560 WELL, CREATING CAPABILITIES TO 5421 03:46:29,560 --> 03:46:32,000 STORE DATA ON ONE OR TWO CLOUDS 5422 03:46:32,000 --> 03:46:33,760 AND THEN ALLOW THAT DATA TO BE 5423 03:46:33,760 --> 03:46:38,680 FOUND ON A THIRD OR DIFFERENT 5424 03:46:38,680 --> 03:46:42,160 CLOUD, THROUGH BASICALLY A VERY 5425 03:46:42,160 --> 03:46:43,800 FACILE METADATA SEARCH 5426 03:46:43,800 --> 03:46:45,560 CAPABILITY, HAVING THAT DATA 5427 03:46:45,560 --> 03:46:48,200 INDEX, COMPUTED ON IN THE CLOUD. 5428 03:46:48,200 --> 03:46:50,160 THERE ARE SOME WORKS WE NEED TO 5429 03:46:50,160 --> 03:46:53,760 DO, SOME PAIN POINTS YOU HEAR 5430 03:46:53,760 --> 03:46:56,640 ABOUT ARE EGRESS CHARGES MOVING 5431 03:46:56,640 --> 03:46:58,360 FROM DIFFERENT CLOUD VENDORS 5432 03:46:58,360 --> 03:46:59,480 OCCURRING EGRESS CHARGES SO 5433 03:46:59,480 --> 03:47:01,240 ENABLING WAYS IN WHICH WE CAN 5434 03:47:01,240 --> 03:47:02,640 SHARE DATA ACROSS CLOUDS OR 5435 03:47:02,640 --> 03:47:05,280 COMPUTE ON THE DATA, WHILE STILL 5436 03:47:05,280 --> 03:47:06,840 MAINTAINING NECESSARY SECURITY 5437 03:47:06,840 --> 03:47:07,680 BOUNDARIES PARTICULARLY FOR 5438 03:47:07,680 --> 03:47:08,760 CONTROLLED ACCESS DATA IS 5439 03:47:08,760 --> 03:47:11,600 SOMETHING THAT WE WILL BE 5440 03:47:11,600 --> 03:47:13,600 ADDRESSING IN THE COMING YEARS 5441 03:47:13,600 --> 03:47:15,120 AND I THINK IS VERY IMPORTANT 5442 03:47:15,120 --> 03:47:18,440 FOR RESEARCH COMMUNITY AS WELL 5443 03:47:18,440 --> 03:47:20,440 AS ENABLING COMPUTING ACROSS 5444 03:47:20,440 --> 03:47:21,440 DIFFERENT ENVIRONMENTS. 5445 03:47:21,440 --> 03:47:23,760 RESEARCHERS DO USE HIGH 5446 03:47:23,760 --> 03:47:24,280 PERFORMANCE COMPUTING, AND 5447 03:47:24,280 --> 03:47:27,600 THERE'S A LOT OF WORK AT NIH, 5448 03:47:27,600 --> 03:47:30,120 DEPARTMENT OF ENERGY, NSF ON 5449 03:47:30,120 --> 03:47:31,520 HYBRID COMMUNITY, YOU'LL SEE IT 5450 03:47:31,520 --> 03:47:33,160 IN THE FEDERAL SPACE AS WELL, 5451 03:47:33,160 --> 03:47:34,640 NEW DISCUSSION ON HYBRID 5452 03:47:34,640 --> 03:47:38,760 COMPUTING ENVIRONMENTS AS A WAY 5453 03:47:38,760 --> 03:47:39,120 FORWARD. 5454 03:47:39,120 --> 03:47:41,600 >> LIKE MANY WOULD IDENTIFY IF 5455 03:47:41,600 --> 03:47:43,320 YOU'RE LIKE ME, HAVEN'T PUT YOUR 5456 03:47:43,320 --> 03:47:45,840 WEDDING PICTURES IN AN ALBUM 5457 03:47:45,840 --> 03:47:47,480 FROM 42 YEARS AGO, WHERE YOU 5458 03:47:47,480 --> 03:47:49,120 BEGIN, YOU'VE GOT PILES OF 5459 03:47:49,120 --> 03:47:49,360 PHOTOS. 5460 03:47:49,360 --> 03:47:50,800 WHAT YOU NEED TO DO IS START 5461 03:47:50,800 --> 03:47:53,640 PUTTING WHAT YOU HAVE CURRENTLY, 5462 03:47:53,640 --> 03:47:55,160 AND ORGANIZE THAT. 5463 03:47:55,160 --> 03:47:59,520 I'M THINKING FOR NEW 5464 03:47:59,520 --> 03:48:03,920 INITIATIVES, TMJ, SHÖGREN'S IS 5465 03:48:03,920 --> 03:48:06,320 LOOKING AT STANDARDIZATION, WE 5466 03:48:06,320 --> 03:48:09,960 HAVE TO MAKE SURE THAT OUR NEW 5467 03:48:09,960 --> 03:48:13,480 INITIATIVES WE'RE INVESTING IN, 5468 03:48:13,480 --> 03:48:17,120 IT'S ACROSS THE BOARD, WOULD TRY 5469 03:48:17,120 --> 03:48:19,320 FROM GROUND ZERO TO ESTABLISH 5470 03:48:19,320 --> 03:48:20,520 THESE, RIGHT? 5471 03:48:20,520 --> 03:48:22,920 I'M HOPING THOSE RESOURCES ARE 5472 03:48:22,920 --> 03:48:24,680 AVAILABLE. 5473 03:48:24,680 --> 03:48:26,760 >> I WANT TO RESONATE ON A 5474 03:48:26,760 --> 03:48:28,640 COMMENT THAT AXEL PUT IN THE 5475 03:48:28,640 --> 03:48:30,080 CHAT, WHICH IS REALLY WHAT WE 5476 03:48:30,080 --> 03:48:33,080 HAVE TO THINK ABOUT THE METADATA 5477 03:48:33,080 --> 03:48:35,080 AND STANDARDS REALLY THE TIME OF 5478 03:48:35,080 --> 03:48:38,280 THE EXPERIMENT IS BEING STOOD 5479 03:48:38,280 --> 03:48:38,560 UP. 5480 03:48:38,560 --> 03:48:40,760 IT'S SO MUCH HARDER TO THINK 5481 03:48:40,760 --> 03:48:42,640 ABOUT THIS WHEN THE EXPERIMENT 5482 03:48:42,640 --> 03:48:43,640 IS DONE AND PUBLISHED AND THEN 5483 03:48:43,640 --> 03:48:46,560 YOU WANT TO SHARE THE DATA. 5484 03:48:46,560 --> 03:48:48,160 IT'S VERY HARD FOR THE COMMUNITY 5485 03:48:48,160 --> 03:48:51,280 TO ACTUALLY HARMONIZE ON DATA 5486 03:48:51,280 --> 03:48:52,680 AFTER THE FACT AND PEOPLE SPEND 5487 03:48:52,680 --> 03:48:57,840 A LOT OF TIME ON THIS PROCESS. 5488 03:48:57,840 --> 03:49:04,080 5489 03:49:04,080 --> 03:49:05,000 >> I COMPLETELY AGREE. 5490 03:49:05,000 --> 03:49:06,880 YOU NEED TO KNOW ABOUT IT BEFORE 5491 03:49:06,880 --> 03:49:09,720 YOU EVEN DO THE EXPERIMENT WHAT 5492 03:49:09,720 --> 03:49:12,440 KIND OF METADATA YOU WILL NEED. 5493 03:49:12,440 --> 03:49:15,720 BASED ON MY OBSERVATION, CAN BE 5494 03:49:15,720 --> 03:49:17,760 DIFFICULT TO ACCOMPLISH THAT 5495 03:49:17,760 --> 03:49:20,640 SEEMINGLY SIMPLE TASK OF GETTING 5496 03:49:20,640 --> 03:49:23,360 PEOPLE TO AGREE ON METADATA 5497 03:49:23,360 --> 03:49:25,000 STANDARDS BECAUSE IT'S 5498 03:49:25,000 --> 03:49:26,200 POLITICAL, EVERYBODY HAS THEIR 5499 03:49:26,200 --> 03:49:29,360 OWN PREFERRED WAY THAT THEY HAVE 5500 03:49:29,360 --> 03:49:31,040 BEEN PUSHING PUBLICATIONS IN THE 5501 03:49:31,040 --> 03:49:33,080 PAST, THIS IS REALLY WHERE 5502 03:49:33,080 --> 03:49:38,120 FUNDING AGENCIES THAT HAVE AN 5503 03:49:38,120 --> 03:49:39,240 OPPORTUNITY TO DEFINE 5504 03:49:39,240 --> 03:49:41,640 REQUIREMENT TO ESSENTIALLY FORCE 5505 03:49:41,640 --> 03:49:42,840 THAT KIND OF COMMUNITY AGREEMENT 5506 03:49:42,840 --> 03:49:46,520 THAT MIGHT NOT HAPPEN OTHERWISE. 5507 03:49:46,520 --> 03:49:46,960 >> ABSOLUTELY. 5508 03:49:46,960 --> 03:49:48,720 THANK YOU, SUSAN. 5509 03:49:48,720 --> 03:49:51,080 JOHN, I WANT TO GIVE YOU A 5510 03:49:51,080 --> 03:49:54,320 CHANCE TO SAY SOMETHING. 5511 03:49:54,320 --> 03:49:55,600 ANYTHING? 5512 03:49:55,600 --> 03:49:56,520 >> THANKS, DR. D'SOUZA. 5513 03:49:56,520 --> 03:49:58,800 I'M IN AGREEMENT WITH THE 5514 03:49:58,800 --> 03:50:00,440 CHALLENGES HERE. 5515 03:50:00,440 --> 03:50:06,160 I SEE DATA FROM A VERY AGNOSTIC 5516 03:50:06,160 --> 03:50:07,640 PERSPECTIVE. 5517 03:50:07,640 --> 03:50:08,240 MY BACKGROUND ISN'T EXPLICITLY 5518 03:50:08,240 --> 03:50:10,240 SCIENTIFIC DATA BUT ALL KIND OF 5519 03:50:10,240 --> 03:50:16,360 DATA, FOR 40 YEARS NOW. 5520 03:50:16,360 --> 03:50:18,120 AND SO I SEE HEALTHY DATA 5521 03:50:18,120 --> 03:50:19,320 ECOSYSTEM AS WE IMAGINE IT IN 5522 03:50:19,320 --> 03:50:24,040 THE FUTURE IS GOING TO INVOLVE 5523 03:50:24,040 --> 03:50:26,640 STARTING LOW AND SLOW, IN TERMS 5524 03:50:26,640 --> 03:50:28,840 OF CATEGORIZATION, AND BUILDING 5525 03:50:28,840 --> 03:50:30,480 UPON LAYERS OF MATURITY AND THE 5526 03:50:30,480 --> 03:50:33,000 KINDS OF METADATA THAT WE 5527 03:50:33,000 --> 03:50:33,360 COLLECT. 5528 03:50:33,360 --> 03:50:35,400 AS WE'RE APPROACHING OUR DATA 5529 03:50:35,400 --> 03:50:38,560 SHARING AND MANAGEMENT PLAN 5530 03:50:38,560 --> 03:50:39,640 REQUIREMENTS, AND CALENDAR YEAR 5531 03:50:39,640 --> 03:50:43,280 23, IT'S ACTUALLY A NICE 5532 03:50:43,280 --> 03:50:46,680 OPPORTUNITY TO START 5533 03:50:46,680 --> 03:50:47,520 ESTABLISHING LOW-LEVEL COMMON 5534 03:50:47,520 --> 03:50:50,080 DATA ELEMENTS FOR ACROSS OUR 5535 03:50:50,080 --> 03:50:51,520 EXTRAMURAL RESEARCH PROGRAM, AND 5536 03:50:51,520 --> 03:50:53,000 OUR INTRAMURAL RESEARCH PROGRAM. 5537 03:50:53,000 --> 03:50:56,360 AND SO I THINK WE'LL SEE SORT OF 5538 03:50:56,360 --> 03:50:57,840 A LAYERING APPROACH TO ADDRESS 5539 03:50:57,840 --> 03:50:58,800 THIS PARTICULAR CHALLENGE BUT 5540 03:50:58,800 --> 03:51:01,040 IT'S GOING TO BE EXCITING, 5541 03:51:01,040 --> 03:51:01,960 THERE'S MANY OPPORTUNITIES 5542 03:51:01,960 --> 03:51:02,360 THERE. 5543 03:51:02,360 --> 03:51:03,880 LOOK FORWARD TO WORKING WITH 5544 03:51:03,880 --> 03:51:06,640 EVERYBODY ON THAT. 5545 03:51:06,640 --> 03:51:13,040 5546 03:51:13,040 --> 03:51:14,440 >> LYNN, WOULD YOU TAKE OVER 5547 03:51:14,440 --> 03:51:15,000 NOW? 5548 03:51:15,000 --> 03:51:18,280 I WANT TO THANK SUSAN AGAIN FOR 5549 03:51:18,280 --> 03:51:19,280 YOUR GENEROUS SHARING OF 5550 03:51:19,280 --> 03:51:20,040 KNOWLEDGE AND TIME. 5551 03:51:20,040 --> 03:51:21,480 >> THANK YOU. 5552 03:51:21,480 --> 03:51:24,360 >> VERY USEFUL. 5553 03:51:24,360 --> 03:51:26,480 5554 03:51:26,480 --> 03:51:28,960 >> WE HAVE ONE LAST ITEM ON THE 5555 03:51:28,960 --> 03:51:30,560 AGENDA FOR THE OPEN SESSION. 5556 03:51:30,560 --> 03:51:35,680 IF WE WANT TO PROCEED WITH THAT. 5557 03:51:35,680 --> 03:51:38,800 WE HAVE A CONCEPT CLEARANCE THAT 5558 03:51:38,800 --> 03:51:41,680 IS -- WE'RE REQUIRED TO DOCUMENT 5559 03:51:41,680 --> 03:51:45,080 THE CLEARANCE OF CONCEPTS TOKING 5560 03:51:45,080 --> 03:51:48,240 PRESENTED FOR THE PURPOSE 5561 03:51:48,240 --> 03:51:49,560 PRESENTING PURPOSE, SCOPE, 5562 03:51:49,560 --> 03:51:51,080 OBJECTIVES IN A PUBLIC FORUM 5563 03:51:51,080 --> 03:51:53,920 SUCH AS COUNCIL MEETING AND 5564 03:51:53,920 --> 03:51:55,160 GIVING COUNSEL MEMBERS THE 5565 03:51:55,160 --> 03:51:57,320 OPPORTUNITY AND PUBLIC AN 5566 03:51:57,320 --> 03:52:03,240 OPPORTUNITY TO COMMENT. 5567 03:52:03,240 --> 03:52:05,000 A PRESENTATION BY STAFF, 5568 03:52:05,000 --> 03:52:07,440 FOLLOWED BY VOTE FOR APPROVAL OF 5569 03:52:07,440 --> 03:52:08,280 THE CONCEPT. 5570 03:52:08,280 --> 03:52:10,720 BASIS OF DEVELOPING A FUTURE 5571 03:52:10,720 --> 03:52:11,800 FUNDING OPPORTUNITY 5572 03:52:11,800 --> 03:52:12,120 ANNOUNCEMENT. 5573 03:52:12,120 --> 03:52:14,320 DR. DENA FISCHER IS WITH US 5574 03:52:14,320 --> 03:52:16,200 TODAY, CHIEF OF THE CENTER FOR 5575 03:52:16,200 --> 03:52:17,840 CLINICAL RESEARCH, SHE WILL 5576 03:52:17,840 --> 03:52:20,600 PRESENT THE CONCEPT AND COUNCIL 5577 03:52:20,600 --> 03:52:25,280 MEMBERS ARE DOCTORS EBOTINO AND 5578 03:52:25,280 --> 03:52:29,240 STRONG WHO WILL LEAD THE 5579 03:52:29,240 --> 03:52:29,760 DISCUSSION. 5580 03:52:29,760 --> 03:52:30,400 >> THANK YOU, EVERYONE. 5581 03:52:30,400 --> 03:52:32,720 I THINK WE'VE HAD A REALLY LONG 5582 03:52:32,720 --> 03:52:35,960 TIME WITHOUT A BREAK SO THANKS 5583 03:52:35,960 --> 03:52:38,160 FOR HANGING IN THERE. 5584 03:52:38,160 --> 03:52:42,760 IT WILL BE JUST A FEW MORE 5585 03:52:42,760 --> 03:52:43,600 MINUTES. 5586 03:52:43,600 --> 03:52:45,200 SO TODAY GOOD AFTERNOON AND GOOD 5587 03:52:45,200 --> 03:52:47,280 MORNING TO THOSE ON THE WEST 5588 03:52:47,280 --> 03:52:53,400 COAST, I'LL BE PRESENTING THE 5589 03:52:53,400 --> 03:52:55,240 CONCEPT, WHICH IS BEING 5590 03:52:55,240 --> 03:52:58,240 SUBMITTED THROUGH THE HEAL 5591 03:52:58,240 --> 03:53:00,880 INITIATIVE, TITLED ORAL 5592 03:53:00,880 --> 03:53:01,840 COMPLICATIONS ARISING FROM 5593 03:53:01,840 --> 03:53:04,040 PHARMACOTHERAPIES TO TREAT 5594 03:53:04,040 --> 03:53:06,960 OPIOID USE DISORDER. 5595 03:53:06,960 --> 03:53:10,360 I'LL TAKE THE NEXT SLIDE. 5596 03:53:10,360 --> 03:53:15,400 SO, WE'VE HEARD ACTUALLY TODAY 5597 03:53:15,400 --> 03:53:19,440 FROM DOCTORS TABAK AND D'SOUZA 5598 03:53:19,440 --> 03:53:22,640 ABOUT NIDCR'S ROLE WITH THE HEAL 5599 03:53:22,640 --> 03:53:24,400 INITIATIVE, TO MAYBE OFFER A 5600 03:53:24,400 --> 03:53:27,600 BRIEF SUMMARY, HELPING TO END 5601 03:53:27,600 --> 03:53:29,000 ADDICTION LONG TERM, THE HEAL 5602 03:53:29,000 --> 03:53:32,280 INITIATIVE IS A TRANS-NIH 5603 03:53:32,280 --> 03:53:36,440 INITIATIVE, WITH PRIMARY GOALS 5604 03:53:36,440 --> 03:53:37,600 TO IMPROVE, PREVENTION AND 5605 03:53:37,600 --> 03:53:39,560 TREATMENT STRATEGIES FOR OPIOID 5606 03:53:39,560 --> 03:53:41,880 MISUSE AND ADDICTION, AND TO 5607 03:53:41,880 --> 03:53:43,640 ENHANCE PAIN MANAGEMENT. 5608 03:53:43,640 --> 03:53:47,240 SO, AS WE'VE HEARD TODAY, NIDCR 5609 03:53:47,240 --> 03:53:49,200 HAS BEEN AND CONTINUES TO BE 5610 03:53:49,200 --> 03:53:51,400 ACTIVE PARTICIPANT IN THE HEAL 5611 03:53:51,400 --> 03:53:55,200 INITIATIVE, SINCE INCEPTION IN 5612 03:53:55,200 --> 03:53:57,320 2018 BECAUSE WE HAVE A 5613 03:53:57,320 --> 03:53:59,640 SIGNIFICANT INTEREST IN PAIN 5614 03:53:59,640 --> 03:54:01,800 RESEARCH FROM PREVENTION TO 5615 03:54:01,800 --> 03:54:04,880 DIAGNOSIS AND TREATMENT OF ACUTE 5616 03:54:04,880 --> 03:54:07,400 AND CHRONIC ORAL FACIAL PAIN 5617 03:54:07,400 --> 03:54:09,000 CONDITIONS AND UNDERSTANDING 5618 03:54:09,000 --> 03:54:13,640 BIOLOGICAL MECHANISMS OF PAIN 5619 03:54:13,640 --> 03:54:13,960 PATHWAYS. 5620 03:54:13,960 --> 03:54:16,360 SO, THE CONCEPT I'M PRESENTING 5621 03:54:16,360 --> 03:54:19,320 TODAY HAS BEEN SUBMITTED TO AND 5622 03:54:19,320 --> 03:54:21,760 ACTUALLY HAS BEEN 5623 03:54:21,760 --> 03:54:22,400 ENTHUSIASTICALLY SUPPORTED BY 5624 03:54:22,400 --> 03:54:24,520 THE HEAL INITIATIVE, SO IF THE 5625 03:54:24,520 --> 03:54:29,320 CONCEPT IS APPROVED BY YOU, OUR 5626 03:54:29,320 --> 03:54:35,040 COUNCIL MEMBERS THEN THE FUNDS 5627 03:54:35,040 --> 03:54:38,920 WOULD BE PROVIDED BY THE HEAL 5628 03:54:38,920 --> 03:54:39,240 INITIATIVE. 5629 03:54:39,240 --> 03:54:40,600 NEXT SLIDE. 5630 03:54:40,600 --> 03:54:42,680 DR. D'SOUZA PAINTED A HIGH LEVEL 5631 03:54:42,680 --> 03:54:45,640 BACKGROUND PICTURE AS WELL, IN 5632 03:54:45,640 --> 03:54:46,920 HER TALK EARLIER TODAY, BUT JUST 5633 03:54:46,920 --> 03:54:49,120 TO OFFER A LITTLE MORE DETAIL, 5634 03:54:49,120 --> 03:54:51,400 THERE ARE THREE DRUGS THAT HAVE 5635 03:54:51,400 --> 03:54:54,920 BEEN FDA APPROVED TO TREAT 5636 03:54:54,920 --> 03:54:57,000 OPIOID DEPENDENCE. 5637 03:54:57,000 --> 03:54:59,000 BUPRENORPHINE, METHADONE, 5638 03:54:59,000 --> 03:54:59,440 NALOXONE. 5639 03:54:59,440 --> 03:55:02,160 AND IN GENERAL DUE TO THE OPIOID 5640 03:55:02,160 --> 03:55:03,560 EPIDEMIC, THERE HAVE BEEN 5641 03:55:03,560 --> 03:55:06,640 EFFORTS TO MAKE TREATMENT FOR 5642 03:55:06,640 --> 03:55:09,360 OPIOID DEPENDENCOR ACCESSIBLE. 5643 03:55:09,360 --> 03:55:11,000 SO SPECIFICALLY BUPRENORPHINE 5644 03:55:11,000 --> 03:55:12,080 PRESCRIBING HAS INCREASED 5645 03:55:12,080 --> 03:55:13,280 RECENTLY, IN RECENT YEARS, 5646 03:55:13,280 --> 03:55:14,960 PARTLY DUE TO THE DRUG 5647 03:55:14,960 --> 03:55:18,120 FORMULATION WHICH IS AVAILABLE 5648 03:55:18,120 --> 03:55:20,120 AS AN ORAL, DISSOLVABLE, 5649 03:55:20,120 --> 03:55:23,560 SUBLINGUAL OR BUCCAL FILM OR 5650 03:55:23,560 --> 03:55:23,960 TABLET. 5651 03:55:23,960 --> 03:55:27,560 AND RECENTLY EARLIER THIS YEAR 5652 03:55:27,560 --> 03:55:30,200 JANUARY OF THIS YEAR, AN FDA 5653 03:55:30,200 --> 03:55:33,160 DRUG SAFETY COMMUNICATION REPORT 5654 03:55:33,160 --> 03:55:35,640 INDICATED ORAL COMPLICATIONS 5655 03:55:35,640 --> 03:55:36,560 ARISING FROM BUPRENORPHINE 5656 03:55:36,560 --> 03:55:37,960 FORMULATIONS DISSOLVED IN THE 5657 03:55:37,960 --> 03:55:40,280 MOUTH SO THERE HAVE BEEN A 5658 03:55:40,280 --> 03:55:41,560 VARIETY OF COMPLICATIONS THAT 5659 03:55:41,560 --> 03:55:46,480 HAVE BEEN REPORTED THROUGH THIS 5660 03:55:46,480 --> 03:55:48,040 FDA COMMUNICATION, RANGING FROM 5661 03:55:48,040 --> 03:55:53,720 DENTAL -- FROM CARIES, ABSCESS, 5662 03:55:53,720 --> 03:55:55,720 TOOTH EROSION, TOOTH LOST, MOST 5663 03:55:55,720 --> 03:55:58,960 REPORTED TO THE FDA ADVERSE 5664 03:55:58,960 --> 03:56:01,360 EVENT RECORDING SYSTEM DATABASE. 5665 03:56:01,360 --> 03:56:03,280 AND THAT SUGGESTED THEY WERE 5666 03:56:03,280 --> 03:56:05,240 REPORTED BY INDIVIDUALS 5667 03:56:05,240 --> 03:56:06,760 RECEIVING BUPRENORPHINE TO TREAT 5668 03:56:06,760 --> 03:56:11,200 OPIOID USE DISORDER. 5669 03:56:11,200 --> 03:56:12,880 NEXT SLIDE. 5670 03:56:12,880 --> 03:56:15,080 SO, ALTHOUGH THERE ARE THESE 5671 03:56:15,080 --> 03:56:17,160 REPORTED ORAL COMPLICATIONS THAT 5672 03:56:17,160 --> 03:56:18,480 WE CAN IMAGINE, OR MORE THAN 5673 03:56:18,480 --> 03:56:20,680 IMAGINE, WE CAN I'M SURE AGREE 5674 03:56:20,680 --> 03:56:23,280 THAT THE BENEFITS OF 5675 03:56:23,280 --> 03:56:24,720 PHARMACOTHERAPIES TO TREAT 5676 03:56:24,720 --> 03:56:27,800 OUDs OUTWEIGH RISKS. 5677 03:56:27,800 --> 03:56:29,080 SO, AS A RESULT, CONSEQUENTLY 5678 03:56:29,080 --> 03:56:33,360 THE GOALS OF THIS INITIATIVE ARE 5679 03:56:33,360 --> 03:56:35,560 TO UNDERSTAND THE BIOLOGY, 5680 03:56:35,560 --> 03:56:37,600 NATURAL HISTORY, DIRECTIONALITY 5681 03:56:37,600 --> 03:56:39,160 OF ORAL COMPLICATIONS ASSOCIATED 5682 03:56:39,160 --> 03:56:41,560 WITH PHARMACOTHERAPIES TO TREAT 5683 03:56:41,560 --> 03:56:43,520 OUDs, AND TO ADDRESS ACCESS TO 5684 03:56:43,520 --> 03:56:45,440 CARE AND OTHER CHALLENGES THAT 5685 03:56:45,440 --> 03:56:52,280 MAY CONTRIBUTE TO DENTAL AND 5686 03:56:52,280 --> 03:56:55,480 ORAL DISEASE IN PEOPLE WITH OUD. 5687 03:56:55,480 --> 03:56:56,840 NEXT SLIDE. 5688 03:56:56,840 --> 03:57:00,520 NEXT SLIDE. 5689 03:57:00,520 --> 03:57:01,280 THANK YOU. 5690 03:57:01,280 --> 03:57:06,480 OKAY. 5691 03:57:06,480 --> 03:57:07,800 SO, THERE ARE NUMEROUS, WE DON'T 5692 03:57:07,800 --> 03:57:10,560 HAVE A LOT OF TIME TO SPEAK TO 5693 03:57:10,560 --> 03:57:13,160 THE FDA COMMUNICATION, SO TO 5694 03:57:13,160 --> 03:57:15,480 ADDRESS THE NUMEROUS GAPS WE 5695 03:57:15,480 --> 03:57:16,760 HAVE ABOUT MECHANISM AND 5696 03:57:16,760 --> 03:57:18,640 CLINICAL COURSE OF DISEASE 5697 03:57:18,640 --> 03:57:21,360 DEVELOPMENT IN PEOPLE RECEIVING 5698 03:57:21,360 --> 03:57:23,040 PHARMACOTHERAPIES TO TREAT OUD, 5699 03:57:23,040 --> 03:57:26,960 THIS INITIATIVE IS RATHER BROAD, 5700 03:57:26,960 --> 03:57:31,200 WILL SUPPORT BROAD RESEARCH 5701 03:57:31,200 --> 03:57:33,840 AREAS INCLUDING BASIC SCIENCE 5702 03:57:33,840 --> 03:57:35,080 RESEARCH TO UNDERSTAND THE 5703 03:57:35,080 --> 03:57:37,960 ENVIRONMENT, INCLUDING THE ROLE 5704 03:57:37,960 --> 03:57:41,040 OF MICROBIAL FLORA, SALIVARY 5705 03:57:41,040 --> 03:57:43,440 PROTECTIVE FACTORS, ALSO 5706 03:57:43,440 --> 03:57:44,320 BUFFERING CAPACITY DURING ORAL 5707 03:57:44,320 --> 03:57:49,000 FARM -- PHARMACOTHERAPY USE FOR 5708 03:57:49,000 --> 03:57:58,800 OUD, CLINICAL RESEARCH IS NEEDED 5709 03:57:58,800 --> 03:58:02,480 SUCH AS EXTENT OF DE NOVO ORAL 5710 03:58:02,480 --> 03:58:13,000 DISEASE DEVELOPMENT, PREEXISTING 5711 03:58:18,720 --> 03:58:29,080 ORAL DISEASE PROGRESSION. 5712 03:58:32,000 --> 03:58:32,600 NEXT SLIDE. 5713 03:58:32,600 --> 03:58:35,320 AREAS INCLUDE COMPONENTS OF 5714 03:58:35,320 --> 03:58:38,160 DELIVERY PRODUCT ON TWO 5715 03:58:38,160 --> 03:58:39,920 STRUCTURES AND TISSUES, 5716 03:58:39,920 --> 03:58:41,480 IDENTIFYING DIRECT AND INDIRECT 5717 03:58:41,480 --> 03:58:43,640 CHANGES IN ORAL CAVITY 5718 03:58:43,640 --> 03:58:46,160 PARAMETERS, AND INTERACTION OF 5719 03:58:46,160 --> 03:58:47,920 THE MICROBIOME WITH HOST 5720 03:58:47,920 --> 03:58:52,040 PROTECTIVE FACTORS IN PRESENCE 5721 03:58:52,040 --> 03:59:02,560 OF PHARMACOTHERAPIES FOR OUD. 5722 03:59:14,560 --> 03:59:17,680 RESEARCH TO CHARACTERIZE 5723 03:59:17,680 --> 03:59:20,600 CLINICAL COURSE, PREEXISTING 5724 03:59:20,600 --> 03:59:23,160 ORAL DISEASE PROGRESSION, AND 5725 03:59:23,160 --> 03:59:27,400 RESEARCH TO ASSESS OR ADDRESS 5726 03:59:27,400 --> 03:59:30,160 ACCESS TO CARE, AND QUALITY OF 5727 03:59:30,160 --> 03:59:32,480 CARE CHALLENGES AND HOW OUD 5728 03:59:32,480 --> 03:59:35,640 TREATMENT MAY IMPACT DENTAL CARE 5729 03:59:35,640 --> 03:59:39,720 UTILIZATION, AND ALSO EXTENT TO 5730 03:59:39,720 --> 03:59:41,760 WHICH INTERACTION WITH MEDICAL 5731 03:59:41,760 --> 03:59:42,640 COLLEAGUES CAN SUPPORT 5732 03:59:42,640 --> 03:59:45,200 CONTINUITY OF MEDICAL AND ORAL 5733 03:59:45,200 --> 03:59:48,320 CARE NEEDS. 5734 03:59:48,320 --> 03:59:51,720 SO WITH THAT, AS DR. KING 5735 03:59:51,720 --> 03:59:59,800 MENTIONED, THERE ARE TWO COUNCIL 5736 03:59:59,800 --> 04:00:00,120 DISCUSSANTS. 5737 04:00:00,120 --> 04:00:05,040 AND I BELIEVE DR. EBETINO IS 5738 04:00:05,040 --> 04:00:08,840 GOING TO START THE DISCUSSION. 5739 04:00:08,840 --> 04:00:13,360 >> WOULD YOU LIKE TO BEGIN? 5740 04:00:13,360 --> 04:00:13,680 >> SURE. 5741 04:00:13,680 --> 04:00:16,760 I THINK DR. STRONG HAD A MORE 5742 04:00:16,760 --> 04:00:17,840 COMPLETE -- 5743 04:00:17,840 --> 04:00:18,320 >> OKAY. 5744 04:00:18,320 --> 04:00:22,040 EITHER ONE. 5745 04:00:22,040 --> 04:00:23,160 WE CAN SWITCH. 5746 04:00:23,160 --> 04:00:25,440 >> I JUST HAD A COUPLE QUICK 5747 04:00:25,440 --> 04:00:28,160 COMMENTS I REALLY SUPPORT THE 5748 04:00:28,160 --> 04:00:29,160 FUNDAMENTAL RESEARCH HERE AND 5749 04:00:29,160 --> 04:00:33,080 BECAUSE THERE'S SO MUCH TO LEARN 5750 04:00:33,080 --> 04:00:36,920 AND ALSO HAD THE OPPORTUNITY TO 5751 04:00:36,920 --> 04:00:38,560 SPEAK WITH PRESCRIBER IN THIS 5752 04:00:38,560 --> 04:00:40,640 AREA AND SEE THE TRAINING 5753 04:00:40,640 --> 04:00:41,840 MATERIALS THAT HAVE BEEN 5754 04:00:41,840 --> 04:00:46,880 AVAILABLE, THERE'S QUITE A LACK 5755 04:00:46,880 --> 04:00:49,080 OF SENSITIVITY TO THE PROBLEMS 5756 04:00:49,080 --> 04:00:52,080 ORALLY, WITH THE USE OF THESE 5757 04:00:52,080 --> 04:00:54,880 DRUGS BY THE PRESCRIBERS. 5758 04:00:54,880 --> 04:00:56,640 SO GO AHEAD, DR. STROM. 5759 04:00:56,640 --> 04:01:00,240 >> NO PROBLEM. 5760 04:01:00,240 --> 04:01:06,160 VERY KIND TO SAY I'LL HAVE MORE 5761 04:01:06,160 --> 04:01:06,800 COMPLETE COMMENTS BUT REGARDLESS 5762 04:01:06,800 --> 04:01:08,560 IN THE INTEREST OF GETTING TO 5763 04:01:08,560 --> 04:01:12,160 THE BREAK, THE PAIRING IS GOOD 5764 04:01:12,160 --> 04:01:14,680 THIS TIME AROUND, I'M A 5765 04:01:14,680 --> 04:01:14,960 CLINICIAN. 5766 04:01:14,960 --> 04:01:16,840 FULL-TIME CLINICIAN. 5767 04:01:16,840 --> 04:01:22,160 YOU HAVE A RESEARCHER, SOMEBODY 5768 04:01:22,160 --> 04:01:23,240 IN THE ECONOMICS PRODUCTION 5769 04:01:23,240 --> 04:01:26,000 INDUSTRY, WE HAVE OUR 5770 04:01:26,000 --> 04:01:27,360 DISCUSSIONS THAT WERE REALLY 5771 04:01:27,360 --> 04:01:28,120 WONDERFUL, THE FACT THAT WEIGH 5772 04:01:28,120 --> 04:01:30,560 WEI CAME TO THE SAME CONCLUSION 5773 04:01:30,560 --> 04:01:32,600 IS EDIFYING FOR THE WHOLE 5774 04:01:32,600 --> 04:01:32,960 CONCEPT. 5775 04:01:32,960 --> 04:01:35,560 WE BOTH AGREED QUITE READILY ON 5776 04:01:35,560 --> 04:01:39,280 THE IMPORTANCE OF THE CONCEPT. 5777 04:01:39,280 --> 04:01:41,600 A COUPLE COMMENTS, WE BOTH 5778 04:01:41,600 --> 04:01:43,440 THOUGHT IT WAS REALLY QUITE 5779 04:01:43,440 --> 04:01:46,640 COOL, LET'S SAY, WE'RE LOOKING 5780 04:01:46,640 --> 04:01:48,200 AT THE MICROBIOME, EXPANDING 5781 04:01:48,200 --> 04:01:54,440 FROM WHAT'S THE IMPACT OF A 5782 04:01:54,440 --> 04:01:58,360 DRUG, MEDICATION, THE pH VALUE 5783 04:01:58,360 --> 04:02:00,760 OF SALIVA, WITH SALIVARY 5784 04:02:00,760 --> 04:02:02,480 TESTING, UNDERSTANDING THE 5785 04:02:02,480 --> 04:02:04,320 MICROBIOME, IT'S IMPORTANT THIS 5786 04:02:04,320 --> 04:02:07,560 IS EXPANDED AS IT IS TO INCLUDE 5787 04:02:07,560 --> 04:02:10,600 THOSE AREAS. 5788 04:02:10,600 --> 04:02:13,400 SECONDLY, AS YOU MENTIONED, THE 5789 04:02:13,400 --> 04:02:14,560 PHYSICIAN COMMUNITY, YOU KNOW, 5790 04:02:14,560 --> 04:02:17,240 THERE'S PRECIOUS LITTLE 5791 04:02:17,240 --> 04:02:18,800 INTERFACE WITH THE PHYSICIAN 5792 04:02:18,800 --> 04:02:20,040 COMMUNITY, MOST PHYSICIANS DO 5793 04:02:20,040 --> 04:02:22,160 NOT DO ANYTHING MORE THAN THE 5794 04:02:22,160 --> 04:02:24,080 BACK OF THE THROAT, SO THAT 5795 04:02:24,080 --> 04:02:27,520 EDUCATION AND COLLABORATION WITH 5796 04:02:27,520 --> 04:02:28,360 THE PHYSICIAN COMMUNITY IS 5797 04:02:28,360 --> 04:02:30,680 ESSENTIAL, IN MY MIND, FOR THIS 5798 04:02:30,680 --> 04:02:34,080 TO -- FOR THE BENCH RESEARCH TO 5799 04:02:34,080 --> 04:02:37,000 BEAR FRUIT, TO HELP PEOPLE OUT. 5800 04:02:37,000 --> 04:02:39,080 THE ONLY SUGGESTION I WOULD HAVE 5801 04:02:39,080 --> 04:02:43,040 MAYBE IS THAT WE FOCUS ON THOSE 5802 04:02:43,040 --> 04:02:44,600 INSURANCE COMPANIES AND THIRD 5803 04:02:44,600 --> 04:02:45,880 PARTY PAYERS WITH THE RECORDS TO 5804 04:02:45,880 --> 04:02:47,960 BE ABLE TO LOOK BACK AND SAY, 5805 04:02:47,960 --> 04:02:50,360 HOW IS THIS GOING TO WORK, HOW 5806 04:02:50,360 --> 04:02:53,320 DID THIS WORK OUT FOR US BY 5807 04:02:53,320 --> 04:02:54,760 SEEING IF UTILIZATION RATE HAS 5808 04:02:54,760 --> 04:02:57,200 GONE UP OR DOWN, THOSE TYPES OF 5809 04:02:57,200 --> 04:02:57,440 THINGS. 5810 04:02:57,440 --> 04:02:59,000 THAT'S MY COMMENTS. 5811 04:02:59,000 --> 04:03:00,880 WE BOTH TOTALLY SUPPORT THE 5812 04:03:00,880 --> 04:03:01,080 CONCEPT. 5813 04:03:01,080 --> 04:03:05,760 THANK YOU FOR YOUR WORK, DENA. 5814 04:03:05,760 --> 04:03:08,680 >> DO ANY COUNCIL MEMBERS HAVE 5815 04:03:08,680 --> 04:03:11,560 ANY QUESTIONS OR COMMENTS? 5816 04:03:11,560 --> 04:03:17,440 5817 04:03:17,440 --> 04:03:21,640 ANYTHING ELSE TO ADD? 5818 04:03:21,640 --> 04:03:23,200 BEFORE WE TAKE A VOTE ON THE 5819 04:03:23,200 --> 04:03:28,080 CONCEPT. 5820 04:03:28,080 --> 04:03:29,200 >> I JUST WONDERED HOW -- WHAT 5821 04:03:29,200 --> 04:03:33,800 DATA THE FDA IS ACTUALLY GETTING 5822 04:03:33,800 --> 04:03:36,000 REAL TIME, IN THIS CASE ON 5823 04:03:36,000 --> 04:03:37,800 BUPRENORPHINE, THAT CAUSED THEM 5824 04:03:37,800 --> 04:03:41,040 TO ISSUE THE ALERT. 5825 04:03:41,040 --> 04:03:43,520 AND HOW BEST WE CAN BE INFORMED 5826 04:03:43,520 --> 04:03:44,320 ABOUT THAT. 5827 04:03:44,320 --> 04:03:47,600 I GUESS SORT OF LOOKING UP THEIR 5828 04:03:47,600 --> 04:03:50,000 WEBSITE, BUT IS THERE ANY OTHER 5829 04:03:50,000 --> 04:03:52,000 WAY, DOES ANYONE KNOW ABOUT 5830 04:03:52,000 --> 04:03:54,720 REALTIME STUDIES ONGOING? 5831 04:03:54,720 --> 04:03:58,040 5832 04:03:58,040 --> 04:04:01,640 5833 04:04:01,640 --> 04:04:03,680 BASICALLY SAYING THAT PARTICULAR 5834 04:04:03,680 --> 04:04:07,440 ALERT DOES NOT WELL JUSTIFY, IT 5835 04:04:07,440 --> 04:04:10,080 WASN'T VALID, BUT THAT'S ONLY 5836 04:04:10,080 --> 04:04:13,120 SECONDHAND AND ANECDOTAL. 5837 04:04:13,120 --> 04:04:15,560 5838 04:04:15,560 --> 04:04:19,360 >> I THINK THIS WAS KIND OF A 5839 04:04:19,360 --> 04:04:21,560 SUMMARY OF COMPLAINTS FROM 5840 04:04:21,560 --> 04:04:22,880 INDIVIDUAL PATIENTS AND 5841 04:04:22,880 --> 04:04:24,320 PRACTITIONERS TO SHARE THAT THIS 5842 04:04:24,320 --> 04:04:26,960 WAS AN UNTOWARD EFFECT THAT THEY 5843 04:04:26,960 --> 04:04:28,400 THOUGHT WAS DIRECTLY ASSOCIATED 5844 04:04:28,400 --> 04:04:33,040 WITH USE OF BUPRENORPHINE. 5845 04:04:33,040 --> 04:04:34,320 >> YEAH. 5846 04:04:34,320 --> 04:04:37,520 SO I THINK JUST TO -- MY 5847 04:04:37,520 --> 04:04:41,080 UNDERSTANDING, CERTAINLY NOT A 5848 04:04:41,080 --> 04:04:41,800 COMPLETE UNDERSTANDING, BUT MY 5849 04:04:41,800 --> 04:04:42,800 UNDERSTANDING IS THAT FOR THE 5850 04:04:42,800 --> 04:04:48,280 MOST PART THIS IS DATA THAT WAS 5851 04:04:48,280 --> 04:04:51,120 REPORTED THROUGH THIS ADVERSE 5852 04:04:51,120 --> 04:04:53,960 EVENT REPORTING SYSTEM, SO IT 5853 04:04:53,960 --> 04:04:57,800 WOULD -- ONE WOULD IMAGINE IT'S 5854 04:04:57,800 --> 04:04:59,760 REPORTED AS DR. WEBSTER CYRIAQUE 5855 04:04:59,760 --> 04:05:01,120 MENTIONED BY PATIENTS, THOSE 5856 04:05:01,120 --> 04:05:03,480 TAKING BUPRENORPHINE AS WELL AS 5857 04:05:03,480 --> 04:05:06,240 PROVIDERS WHO MIGHT BE SEEING 5858 04:05:06,240 --> 04:05:07,040 THESE ORAL COMPLICATIONS OR 5859 04:05:07,040 --> 04:05:09,280 MAYBE HEARING ABOUT THEM FROM 5860 04:05:09,280 --> 04:05:10,160 THEIR PATIENTS. 5861 04:05:10,160 --> 04:05:12,480 I DO BELIEVE THEY MIGHT HAVE 5862 04:05:12,480 --> 04:05:18,920 ALSO INCORPORATED THE LITTLE 5863 04:05:18,920 --> 04:05:21,880 BIT OF DATA TO CASE SERIES, TO 5864 04:05:21,880 --> 04:05:23,080 CASE SERIES WRITTEN BY THE SAME 5865 04:05:23,080 --> 04:05:27,160 SET OF AUTHORS SO PERHAPS THE 5866 04:05:27,160 --> 04:05:28,800 SAME PATIENT POPULATION FROM A 5867 04:05:28,800 --> 04:05:32,160 NUMBER OF YEARS AGO. 5868 04:05:32,160 --> 04:05:33,400 FROM I THINK 2013 AND 2014. 5869 04:05:33,400 --> 04:05:35,120 SO THAT WOULD BE WHERE THE DATA 5870 04:05:35,120 --> 04:05:38,440 IS COMING FROM BUT I DON'T HAVE 5871 04:05:38,440 --> 04:05:40,040 DIRECT ACCESS TO IT. 5872 04:05:40,040 --> 04:05:44,880 WHICH I THINK WE NEED TO DO SOME 5873 04:05:44,880 --> 04:05:47,280 RESEARCH TO BETTER UNDERSTAND 5874 04:05:47,280 --> 04:05:49,360 WHAT IT IS THAT THE FDA HAD 5875 04:05:49,360 --> 04:05:51,520 REPORTED. 5876 04:05:51,520 --> 04:05:54,080 5877 04:05:54,080 --> 04:05:55,280 >> ARE THERE ANY OTHER QUESTIONS 5878 04:05:55,280 --> 04:05:59,160 OR COMMENTS? 5879 04:05:59,160 --> 04:05:59,560 P. 5880 04:05:59,560 --> 04:06:02,600 >> ONE LAST COMMENT, MY LAST 5881 04:06:02,600 --> 04:06:04,200 MEETING, THANK YOU, THE CONCEPT 5882 04:06:04,200 --> 04:06:06,200 CLEARANCE PART FOR THE BOARD 5883 04:06:06,200 --> 04:06:07,720 MEMBERS, PANEL MEMBERS, NEWER, 5884 04:06:07,720 --> 04:06:09,600 THIS IS THE BEST PARTHE 5885 04:06:09,600 --> 04:06:11,240 WHOLE MEETING, YOU GET TO DELVE 5886 04:06:11,240 --> 04:06:12,840 INTO SOMETHING, GET TO KNOW 5887 04:06:12,840 --> 04:06:14,120 STAFF AND IT'S BEEN WONDERFUL 5888 04:06:14,120 --> 04:06:15,160 FOR ME TO PARTICIPATE. 5889 04:06:15,160 --> 04:06:17,280 THANK YOU VERY MUCH FOR ASKING 5890 04:06:17,280 --> 04:06:18,480 ME, ONE FINAL TIME. 5891 04:06:18,480 --> 04:06:19,080 >> THANK YOU, JOEL. 5892 04:06:19,080 --> 04:06:20,800 THANK YOU FOR THE LOVELY MESSAGE 5893 04:06:20,800 --> 04:06:25,480 YOU YOU WROTE IN THE CHAT. 5894 04:06:25,480 --> 04:06:26,800 WE'LL MISS YOU, BUT YOU'RE NOT 5895 04:06:26,800 --> 04:06:28,760 TOO FAR OFF. 5896 04:06:28,760 --> 04:06:31,240 WE CAN REACH YOU, YEAH. 5897 04:06:31,240 --> 04:06:35,160 >> I HAVE TO ADD A THANK YOU TO 5898 04:06:35,160 --> 04:06:35,640 DR. STROM. 5899 04:06:35,640 --> 04:06:38,480 OVER THE YEARS, DR. STROM, YOU 5900 04:06:38,480 --> 04:06:41,600 HAVE BEEN A COUNCIL REVIEWER FOR 5901 04:06:41,600 --> 04:06:43,000 MULTIPLE CONCEPTS I BROUGHT 5902 04:06:43,000 --> 04:06:45,480 FORWARD, I'VE JUST ENJOYED OUR 5903 04:06:45,480 --> 04:06:46,600 CONVERSATIONS AND THANK YOU FOR 5904 04:06:46,600 --> 04:06:48,680 ALL OF YOUR INPUT OVER THE 5905 04:06:48,680 --> 04:06:49,640 YEARS. 5906 04:06:49,640 --> 04:06:50,440 >> THANKS. 5907 04:06:50,440 --> 04:06:51,080 THANK YOU. 5908 04:06:51,080 --> 04:06:52,360 >> THANK YOU FOR YOUR COUNCIL 5909 04:06:52,360 --> 04:06:54,800 CONTRIBUTIONS. 5910 04:06:54,800 --> 04:06:56,280 >> WOULD A MEMBER OF COUNCIL 5911 04:06:56,280 --> 04:06:58,720 LIKE TO MAKE A MOTION FOR 5912 04:06:58,720 --> 04:07:01,360 RECOMMENDATION TO APPROVE THIS 5913 04:07:01,360 --> 04:07:06,040 CONCEPT? 5914 04:07:06,040 --> 04:07:11,520 >> SO MOVED. 5915 04:07:11,520 --> 04:07:12,400 >> I'LL SECOND. 5916 04:07:12,400 --> 04:07:13,800 >> ALL IN FAVOR? 5917 04:07:13,800 --> 04:07:14,720 >> AYE. 5918 04:07:14,720 --> 04:07:15,640 >> AYE. 5919 04:07:15,640 --> 04:07:16,120 >> AYE. 5920 04:07:16,120 --> 04:07:16,400 >> AYE. 5921 04:07:16,400 --> 04:07:18,600 >> ANY OPPOSED? 5922 04:07:18,600 --> 04:07:21,040 OKAY. 5923 04:07:21,040 --> 04:07:22,440 5924 04:07:22,440 --> 04:07:25,000 WE HAVE NOW REACHED THE END OF 5925 04:07:25,000 --> 04:07:26,320 THE OPEN SESSION. 5926 04:07:26,320 --> 04:07:28,080 AND I'D LIKE TO REMIND EVERYONE 5927 04:07:28,080 --> 04:07:30,680 YOU CAN SUBMIT COMMENTS OR 5928 04:07:30,680 --> 04:07:31,760 QUESTIONS ABOUT THE 5929 04:07:31,760 --> 04:07:33,440 PRESENTATIONS IN OPEN SESSION 5930 04:07:33,440 --> 04:07:35,720 TODAY TO THE MAILBOX THAT WE'LL 5931 04:07:35,720 --> 04:07:40,040 POST ON OUR FINAL SLIDE, UNTIL 5932 04:07:40,040 --> 04:07:40,760 JUNE 1, 2022. 5933 04:07:40,760 --> 04:07:43,040 AND I WILL NOW TURN THE MEETING 5934 04:07:43,040 --> 04:07:44,720 BACK OVER TO DR. D'SOUZA FOR 5935 04:07:44,720 --> 04:07:50,160 CLOSING COMMENTS. 5936 04:07:50,160 --> 04:07:55,200 >> I KNOW IT WAS AN ATYPICAL 5937 04:07:55,200 --> 04:07:56,640 SESSION BUT WAS ENRICHED WITH 5938 04:07:56,640 --> 04:07:58,040 THE INFORMATION LARRY TABAK 5939 04:07:58,040 --> 04:07:59,960 PROVIDED, CONTEXT OF THE FUTURE, 5940 04:07:59,960 --> 04:08:03,560 BRINGING IN THEMES OF SCIENCE. 5941 04:08:03,560 --> 04:08:06,280 I DIDN'T LISTEN BECAUSE WE WERE 5942 04:08:06,280 --> 04:08:06,920 INTERRUPTED WITH INTERNET 5943 04:08:06,920 --> 04:08:08,160 DIFFICULTIES BUT IT'S THE SAME 5944 04:08:08,160 --> 04:08:10,760 THING AS CONNECTING THE DOTS AND 5945 04:08:10,760 --> 04:08:12,640 THINKING SYSTEMS APPROACHES, 5946 04:08:12,640 --> 04:08:15,800 WHERE YOU NEED 5947 04:08:15,800 --> 04:08:16,360 MULTI-DISCIPLINARY THINKING. 5948 04:08:16,360 --> 04:08:19,440 SO I WANT TO SAY THANK YOU FOR 5949 04:08:19,440 --> 04:08:20,200 LISTENING IN. 5950 04:08:20,200 --> 04:08:25,440 WE'RE ENDING VERY MUCH ON TIME, 5951 04:08:25,440 --> 04:08:27,160 SO DESPITE THOSE HARDSHIPS, I 5952 04:08:27,160 --> 04:08:30,080 WANT TO STAY CONNECTED. 5953 04:08:30,080 --> 04:08:34,200 WE HAVE DIFFERENT FORUMS. 5954 04:08:34,200 --> 04:08:35,280 SUCCESSFUL ATTRACTING AN 5955 04:08:35,280 --> 04:08:36,480 AUDIENCE WHO IS INTERESTED IN 5956 04:08:36,480 --> 04:08:38,560 THE STRATEGIC PLAN ITSELF, IT 5957 04:08:38,560 --> 04:08:45,120 WAS A WEBINAR, ORGANIZED BY 5958 04:08:45,120 --> 04:08:46,000 JENNIFER WEBSTER CYRIAQUE 5959 04:08:46,000 --> 04:08:48,040 AVAILABLE FOR YOUR VIEWING. 5960 04:08:48,040 --> 04:08:49,720 IT DOES GO DEEP INTO WHAT WE 5961 04:08:49,720 --> 04:08:51,360 PLAN TO DO FOR THE FUTURE. 5962 04:08:51,360 --> 04:08:53,320 WE HAVE ANOTHER ONE COMING UP IN 5963 04:08:53,320 --> 04:08:53,680 JUNE. 5964 04:08:53,680 --> 04:08:57,480 BUT IT WILL BE MOST LIKELY JULY, 5965 04:08:57,480 --> 04:08:58,440 PERHAPS EVEN AUGUST, WE'RE 5966 04:08:58,440 --> 04:09:01,520 TRYING TO SPACE IT OUT, ACTUALLY 5967 04:09:01,520 --> 04:09:03,480 TAKING THE REPORT INTO ACTION, 5968 04:09:03,480 --> 04:09:06,360 BY LOOKING AT HOW BEST WE CAN 5969 04:09:06,360 --> 04:09:09,440 COME TOGETHER TO REINFORCE 5970 04:09:09,440 --> 04:09:10,640 PREVENTION, PREVENTIVE RESEARCH, 5971 04:09:10,640 --> 04:09:12,320 PREVENTIVE INTERVENTIONS, ET 5972 04:09:12,320 --> 04:09:12,600 CETERA. 5973 04:09:12,600 --> 04:09:14,960 THOUGHTS, A LOT OF BEHAVIORAL 5974 04:09:14,960 --> 04:09:17,520 CONDITIONING, AND IT WILL 5975 04:09:17,520 --> 04:09:19,320 INVOLVE ALL MAJOR STAKEHOLDER 5976 04:09:19,320 --> 04:09:23,840 ORGANIZATIONS, THEIR ROLE IN OUR 5977 04:09:23,840 --> 04:09:24,600 PROFESSION. 5978 04:09:24,600 --> 04:09:26,280 WITH THAT, THERE WILL BE 5979 04:09:26,280 --> 04:09:26,560 REMINDERS. 5980 04:09:26,560 --> 04:09:28,640 THANK YOU FOR JOINING. 5981 04:09:28,640 --> 04:09:29,640 IF YOU MISSED ANY PORTION IT 5982 04:09:29,640 --> 04:09:32,240 WILL BE AVAILABLE ON THE WEBCAST 5983 04:09:32,240 --> 04:09:32,480 RECORDING. 5984 04:09:32,480 --> 04:09:33,280 THANK YOU AGAIN. 5985 04:09:33,280 --> 04:09:35,360 BE SAFE AND BE WELL. 5986 04:09:35,360 --> 04:09:36,320 ENJOY THE SUMMER. 5987 04:09:36,320 --> 04:09:39,480 WE WILL MOST LIKELY BE VIRTUAL 5988 04:09:39,480 --> 04:09:41,240 IN SEPTEMBER SO PREPARE FOR 5989 04:09:41,240 --> 04:09:41,480 THAT. 5990 04:09:41,480 --> 04:09:43,880 IF THINGS CHANGE, IT MIGHT BE 5991 04:09:43,880 --> 04:09:45,440 HYBRID BUT WE'RE LEANING TOWARDS 5992 04:09:45,440 --> 04:09:47,840 VIRTUAL, RIGHT, LYNN? 5993 04:09:47,840 --> 04:09:48,280 MORE LIKELY? 5994 04:09:48,280 --> 04:09:51,760 >> YES, YES, MORE LIKELY 5995 04:09:51,760 --> 04:09:52,000 VIRTUAL. 5996 04:09:52,000 --> 04:09:52,880 >> THANK YOU VERY MUCH. 5997 04:09:52,880 --> 04:09:56,840 THANK YOU TO OUR SPEAKERS, TO 5998 04:09:56,840 --> 04:10:02,320 NIKI, AND SUSAN, AND ALL THOSE 5999 04:10:02,320 --> 04:10:03,840 WHO SUPPORTED THEIR FINDINGS AND 6000 04:10:03,840 --> 04:10:05,520 RESEARCH IN THE AREAS OF DATA 6001 04:10:05,520 --> 04:10:06,400 SCIENCE AS WELL. 6002 04:10:06,400 --> 04:10:07,280 THANK YOU. 6003 04:10:07,280 --> 04:10:09,240 TAKE CARE. 6004 04:10:09,240 --> 04:10:12,080 WE SHALL NOW GO INTO CLOSED 6005 04:10:12,080 --> 00:00:00,000 SESSION.