1 00:00:06,311 --> 00:00:07,613 ALL RIGHT. 2 00:00:07,613 --> 00:00:09,948 GOOD AFTERNOON, EVERYONE. 3 00:00:09,948 --> 00:00:11,483 WELCOME TO EVERYONE JOINING TO 4 00:00:11,483 --> 00:00:16,055 THE OPEN SESSION OF THE NDCD 5 00:00:16,055 --> 00:00:17,122 ADVISORY COUNCIL. 6 00:00:17,122 --> 00:00:18,657 REMINDER, THIS OPEN SESSION OF 7 00:00:18,657 --> 00:00:20,225 THE MEETING IS BEING VIDEOCAST 8 00:00:20,225 --> 00:00:20,626 LIVE. 9 00:00:20,626 --> 00:00:23,495 IT WILL ALSO BE ARCHIVED FOR 10 00:00:23,495 --> 00:00:26,498 VIEWING BY MEMBERS OF THE PUBLIC 11 00:00:26,498 --> 00:00:28,534 AND NIH STAFF FOR ONE YEAR. 12 00:00:28,534 --> 00:00:32,104 SO, AS ALWAYS, WE WILL START 13 00:00:32,104 --> 00:00:33,739 WITH ADMINISTRATIVE ISSUES, AND 14 00:00:33,739 --> 00:00:36,241 I'M HAPPY TO BEGIN THE PROGRAM 15 00:00:36,241 --> 00:00:37,543 WITH INTRODUCTIONS OF THE 16 00:00:37,543 --> 00:00:38,644 COUNCIL MEMBERS. 17 00:00:38,644 --> 00:00:40,479 I WILL CALL ON EACH MEMBER OF 18 00:00:40,479 --> 00:00:43,115 THE COUNCIL AND ASK YOU TO TURN 19 00:00:43,115 --> 00:00:45,184 ON YOUR VIDEO, STATE YOUR NAME 20 00:00:45,184 --> 00:00:47,319 AND AFFILIATION, AND JUST SAY A 21 00:00:47,319 --> 00:00:50,122 COUPLE WORDS ABOUT YOUR 22 00:00:50,122 --> 00:00:50,756 EXPERTISE. 23 00:00:50,756 --> 00:00:56,328 AND WE'LL START WITH DR. LINDA 24 00:00:56,328 --> 00:01:00,566 BARLOW. 25 00:01:00,566 --> 00:01:01,900 I THINK EVERYBODY IS TRYING TO 26 00:01:01,900 --> 00:01:03,735 FIGURE OUT HOW IN TEAMS TO TURN 27 00:01:03,735 --> 00:01:05,270 ON THEIR VIDEO. 28 00:01:05,270 --> 00:01:05,771 IS SHE HERE? 29 00:01:05,771 --> 00:01:08,440 >> SHE WAS HERE BUT I DON'T SEE 30 00:01:08,440 --> 00:01:09,741 HER HERE ANYMORE. 31 00:01:09,741 --> 00:01:16,515 >> I MADE HER A PRESENTER. 32 00:01:16,515 --> 00:01:17,616 >> I'LL COME BACK TO HER. 33 00:01:17,616 --> 00:01:20,285 >> THERE'S A LOT OF MEMBERS WHO 34 00:01:20,285 --> 00:01:21,887 HAVEN'T FIGURED OUT HOW TO JOIN 35 00:01:21,887 --> 00:01:25,057 YET, YOU MAY END UP QUITE A FEW 36 00:01:25,057 --> 00:01:26,725 PEOPLE TRYING TO . 37 00:01:26,725 --> 00:01:27,159 >> OH NO. 38 00:01:27,159 --> 00:01:29,194 OKAY, ALL RIGHT. 39 00:01:29,194 --> 00:01:30,329 WELL, WHAT WE COULD DO, WE HAVE 40 00:01:30,329 --> 00:01:31,930 TO TAKE A VOTE NEXT ON THE 41 00:01:31,930 --> 00:01:35,334 MINUTES, SO I'M NOT SURE WE WANT 42 00:01:35,334 --> 00:01:39,538 TO DO THAT WITHOUT PEOPLE 43 00:01:39,538 --> 00:01:41,473 PRESENT EITHER. 44 00:01:41,473 --> 00:01:43,208 I'LL GO THROUGH THE LIST, I SEE 45 00:01:43,208 --> 00:01:44,343 SOME MEMBERS OF THE COUNCIL 46 00:01:44,343 --> 00:01:45,777 HERE, WE'LL SEE WHO CAN 47 00:01:45,777 --> 00:01:47,679 INTRODUCE THEMSELVES AND PICK 48 00:01:47,679 --> 00:01:48,180 UP. 49 00:01:48,180 --> 00:01:53,285 SO, DR. BARLOW'S NOT HERE, I 50 00:01:53,285 --> 00:01:54,186 THINK, KATHERINE BOOTEN IS NOT 51 00:01:54,186 --> 00:01:58,157 ABLE TO AFTERNOON. 52 00:01:58,157 --> 00:02:01,460 DR. EMILY BUSS, I SEE EMILY. 53 00:02:01,460 --> 00:02:03,328 >> YES, I'M HERE. 54 00:02:03,328 --> 00:02:05,364 EMILY BUSS, UNIVERSITY OF NORTH 55 00:02:05,364 --> 00:02:07,032 CAROLINA, AT CHAPEL HILL, AND I 56 00:02:07,032 --> 00:02:09,535 STUDY HUMAN HEARING WITH A FOCUS 57 00:02:09,535 --> 00:02:11,837 ON AUDITORY DEVELOPMENT AND 58 00:02:11,837 --> 00:02:13,705 EFFECTS OF HEARING LOSS. 59 00:02:13,705 --> 00:02:14,239 >> GREAT. 60 00:02:14,239 --> 00:02:17,209 THANK YOU. 61 00:02:17,209 --> 00:02:27,753 NEXT MISS VICKIE DEAL WILLIAMS. 62 00:02:29,054 --> 00:02:30,722 I SEE HER NAME BUT I THINK SHE'S 63 00:02:30,722 --> 00:02:34,426 NOT QUITE HERE YET. 64 00:02:34,426 --> 00:02:35,394 >> I AM HERE. 65 00:02:35,394 --> 00:02:39,898 TRYING TO GET TO THE BUTTONS. 66 00:02:39,898 --> 00:02:41,633 I'M VICKIE DEAL WILLIAMS, CHIEF 67 00:02:41,633 --> 00:02:43,202 EXECUTIVE OFFICER AT THE 68 00:02:43,202 --> 00:02:48,207 AMERICAN SPEECH LANGUAGE HEARING 69 00:02:48,207 --> 00:02:51,176 ASSOCIATION. 70 00:02:51,176 --> 00:02:54,713 >> THANK YOU. 71 00:02:54,713 --> 00:02:55,547 DR. JAY GOTTFRIED. 72 00:02:55,547 --> 00:02:59,618 DO NOT SEE HIM. 73 00:02:59,618 --> 00:03:06,725 HOW ABOUT DR. ANDY BROAST? 74 00:03:06,725 --> 00:03:07,659 DR. KIA JOHNSON? 75 00:03:07,659 --> 00:03:13,966 >> SHE DOESN'T SEEM TO HAVE ANY 76 00:03:13,966 --> 00:03:14,733 SOUND. 77 00:03:14,733 --> 00:03:15,334 >> ANDY -- 78 00:03:15,334 --> 00:03:16,201 >> HE'S HERE. 79 00:03:16,201 --> 00:03:16,435 >> OKAY. 80 00:03:16,435 --> 00:03:26,712 >> WE CAN'T SEEM TO HEAR HIM. 81 00:03:26,712 --> 00:03:29,581 >> MY NAME IS KIA JOHNSON, 82 00:03:29,581 --> 00:03:31,149 DIRECTOR OF ARTHUR BLANK CENTER 83 00:03:31,149 --> 00:03:36,355 FOR STUTTERING EDUCATION AND 84 00:03:36,355 --> 00:03:36,888 RESEARCH, AFFILIATED WITH 85 00:03:36,888 --> 00:03:45,097 UNIVERSITY OF TEXAS AUSTIN, AREA 86 00:03:45,097 --> 00:03:45,964 IS STUTTERING IN CULTURAL 87 00:03:45,964 --> 00:03:46,431 DIVERSE COMMUNITIES. 88 00:03:46,431 --> 00:03:49,067 GLAD TO BE HERE. 89 00:03:49,067 --> 00:03:52,437 >> THANK YOU. 90 00:03:52,437 --> 00:03:53,005 DR. KIRAN? 91 00:03:53,005 --> 00:03:58,410 >> HOPEFULLY YOU CAN HEAR ME, 92 00:03:58,410 --> 00:04:00,078 SWATHI KIRAN, BOSTON UNIVERSITY, 93 00:04:00,078 --> 00:04:03,181 DIRECTOR FOR CENTER FOR BRAIN 94 00:04:03,181 --> 00:04:11,456 RECOVERY, AREA OF EXPERTISE IS 95 00:04:11,456 --> 00:04:12,658 APHASIA. 96 00:04:12,658 --> 00:04:14,059 >> NEXT IS DR. OWANI WHO WAS NOT 97 00:04:14,059 --> 00:04:24,603 ABLE TO JOIN US THIS AFTERNOON. 98 00:04:30,442 --> 00:04:33,345 >> DR. DAN MORFELD, OHIO STATE 99 00:04:33,345 --> 00:04:35,947 UNIVERSITY, MY AREA IS BALANCE 100 00:04:35,947 --> 00:04:44,122 AND SPATIAL ORIENTATION. 101 00:04:44,122 --> 00:04:45,257 >> JAY PICARELLO, PROFESSOR AT 102 00:04:45,257 --> 00:04:49,194 WASHINGTON UNIVERSITY, 103 00:04:49,194 --> 00:04:49,761 ST. LOUIS, PRACTICING 104 00:04:49,761 --> 00:04:51,730 OTOLARYNGOLOGIST, CLINICAL 105 00:04:51,730 --> 00:04:53,365 TRIALS IN TINNITUS, 106 00:04:53,365 --> 00:04:55,334 COVID-RELATED ANOSMIA AND DIRECT 107 00:04:55,334 --> 00:04:59,071 THREE CLINICAL RESEARCH TRAINING 108 00:04:59,071 --> 00:05:02,741 PROGRAMS, TWO R25s AND OUR 109 00:05:02,741 --> 00:05:05,310 INSTITUTIONAL CTSA TL-1. 110 00:05:05,310 --> 00:05:06,945 THANK YOU. 111 00:05:06,945 --> 00:05:08,814 >> THANK YOU. 112 00:05:08,814 --> 00:05:18,023 NEXT DR. RAMIREZ STAPLETON. 113 00:05:18,023 --> 00:05:19,891 WE'LL COME BACK TO HER. 114 00:05:19,891 --> 00:05:26,798 >> NOT HERE YET, OKAY. 115 00:05:26,798 --> 00:05:28,900 >> AND DR. MARIO SVIRSKY, IS HE 116 00:05:28,900 --> 00:05:29,101 SNEER. 117 00:05:29,101 --> 00:05:35,674 >> I DON'T THINK MARIO IS HERE 118 00:05:35,674 --> 00:05:37,209 YET. 119 00:05:37,209 --> 00:05:40,178 >> DR. TUESDAY AN THIBEAULT. 120 00:05:40,178 --> 00:05:42,247 >> I'M HERE. 121 00:05:42,247 --> 00:05:46,184 SUSAN THIBEAULT, PROFESSOR OF 122 00:05:46,184 --> 00:05:48,387 OTOLARYNGOLOGY, NECK SURGERY, 123 00:05:48,387 --> 00:05:48,687 UNIVERSITY 124 00:05:48,687 --> 00:05:59,231 UNIVERSITY OF WISCONSIN, I STUDY 125 00:06:00,999 --> 00:06:05,737 IMMUNOLOGY AND DEVELOPMENT OF 126 00:06:05,737 --> 00:06:08,807 LARYNX. 127 00:06:08,807 --> 00:06:09,708 >> DR. LARRY TRUSSELL? 128 00:06:09,708 --> 00:06:12,644 >> HELLO, EVERYONE. 129 00:06:12,644 --> 00:06:16,081 I'M LARRY TRUSSELL, PROFESSOR AT 130 00:06:16,081 --> 00:06:18,483 OREGON HEALTH SCIENCE UNIVERSITY 131 00:06:18,483 --> 00:06:19,851 IN PORTLAND, OREGON. 132 00:06:19,851 --> 00:06:21,953 AND INTERIM DIRECTOR OF OREGON 133 00:06:21,953 --> 00:06:24,055 HEARING RESEARCH CENTER. 134 00:06:24,055 --> 00:06:28,093 AND MY SPECIALTY FOR RESEARCH IS 135 00:06:28,093 --> 00:06:30,695 IN THE MOLECULAR BIOLOGY AND 136 00:06:30,695 --> 00:06:33,632 BIOPHYSICS AND PHYSIOLOGY OF 137 00:06:33,632 --> 00:06:37,836 CENTRAL AUDITORY NEURONS. 138 00:06:37,836 --> 00:06:39,805 >> THANK YOU. 139 00:06:39,805 --> 00:06:40,872 DR. WALLHAGEN, I'M NOT SURE IF 140 00:06:40,872 --> 00:06:45,177 SHE WAS GOING TO BE HERE. 141 00:06:45,177 --> 00:06:48,213 AND DR. NANCY YOUNG. 142 00:06:48,213 --> 00:06:51,283 >> I'M HERE. 143 00:06:51,283 --> 00:06:51,917 I JUST JOINED. 144 00:06:51,917 --> 00:06:53,685 >> I'M SORRY. 145 00:06:53,685 --> 00:06:56,221 >> I HAD TROUBLE GETTING IN. 146 00:06:56,221 --> 00:07:00,826 BUT I DID FINALLY MAKE IT IN. 147 00:07:00,826 --> 00:07:02,227 OH, MEG WALLHAGEN, UC-SAN 148 00:07:02,227 --> 00:07:05,330 FRANCISCO, SCHOOL OF NURSING. 149 00:07:05,330 --> 00:07:07,899 AND IN GERIATRICS. 150 00:07:07,899 --> 00:07:08,200 >> GREAT. 151 00:07:08,200 --> 00:07:09,701 THANK YOU. 152 00:07:09,701 --> 00:07:13,371 NANCY YOUNG, DR. NANCY YOUNG. 153 00:07:13,371 --> 00:07:14,840 >> GOOD AFTERNOON. 154 00:07:14,840 --> 00:07:18,743 I'M NANCY YOUNG, A SURGEON AT 155 00:07:18,743 --> 00:07:20,912 LURIE CHILDREN'S HOSPITAL IN 156 00:07:20,912 --> 00:07:25,083 CHICAGO, WHERE I AM THE HEAD OF 157 00:07:25,083 --> 00:07:29,754 OTOLY IN THE DIVISION OF 158 00:07:29,754 --> 00:07:31,790 OTOLARYNGOLOGY, PROFESSOR AT 159 00:07:31,790 --> 00:07:33,291 NORTHWESTERN UNIVERSITY. 160 00:07:33,291 --> 00:07:37,128 AND MY AREA OF RESEARCH INTEREST 161 00:07:37,128 --> 00:07:38,663 IS NEUROPLASTICITY OF CHILDREN 162 00:07:38,663 --> 00:07:42,234 WITH HEARING LOSS AND PREDICTING 163 00:07:42,234 --> 00:07:43,468 LANGUAGE OUTCOMES. 164 00:07:43,468 --> 00:07:45,937 >> THANK YOU. 165 00:07:45,937 --> 00:07:49,074 WE HAVE TWO EX OFFICIO MEMBERS 166 00:07:49,074 --> 00:07:51,710 WHO REPRESENT OUR FEDERAL 167 00:07:51,710 --> 00:07:56,214 PARTNERS. 168 00:07:56,214 --> 00:08:05,657 THE FIRST IS DR. SEAN 169 00:08:05,657 --> 00:08:06,191 McCLENNEY. 170 00:08:06,191 --> 00:08:07,359 >> HE WAS HAVING TROUBLE GETTING 171 00:08:07,359 --> 00:08:15,200 INTO THE MEETING, MAY NOT BE IN 172 00:08:15,200 --> 00:08:15,767 YET. 173 00:08:15,767 --> 00:08:16,835 >> AND FROM THE DEPARTMENT OF 174 00:08:16,835 --> 00:08:17,269 DEFENSE, NOT HERE. 175 00:08:17,269 --> 00:08:19,271 I'LL SEE IF THE FIVE PEOPLE NOT 176 00:08:19,271 --> 00:08:21,139 HERE INITIALLY ARE HERE. 177 00:08:21,139 --> 00:08:31,082 DR. LINDA BARLOW, ARE YOU HERE? 178 00:08:31,082 --> 00:08:35,453 DR. JAY GOTTFRIED? 179 00:08:35,453 --> 00:08:37,422 DR. ANDY GROVES? 180 00:08:37,422 --> 00:08:42,327 >> STILL CAN'T HEAR YOU, ANDY. 181 00:08:42,327 --> 00:08:46,731 >> ALL RIGHT. 182 00:08:46,731 --> 00:08:53,772 I'M SORRY, ANDY. 183 00:08:53,772 --> 00:08:58,376 DR. RAMIREZ STAPLETON? 184 00:08:58,376 --> 00:08:59,644 AND DR. MARIO SVIRSKY. 185 00:08:59,644 --> 00:09:01,846 THANK YOU ALL FOR YOUR SERVICE 186 00:09:01,846 --> 00:09:03,748 AND FOR ALL OF THE EXPERTISE 187 00:09:03,748 --> 00:09:06,251 THAT YOU CONTRIBUTE TO THIS 188 00:09:06,251 --> 00:09:07,052 COUNCIL. 189 00:09:07,052 --> 00:09:08,086 WE'LL MOVE ON NEXT, I THINK 190 00:09:08,086 --> 00:09:13,625 WE'RE READY FOR THE SLIDES 191 00:09:13,625 --> 00:09:14,025 AGAIN. 192 00:09:14,025 --> 00:09:16,561 AND THE CONSIDERATION OF THE 193 00:09:16,561 --> 00:09:17,195 COUNCIL OPERATING PROCEDURES, 194 00:09:17,195 --> 00:09:20,065 AND THE MINUTES FROM OUR LAST 195 00:09:20,065 --> 00:09:21,099 MEETING, WHICH WAS HEALTH 196 00:09:21,099 --> 00:09:31,343 SEPTEMBER 12. 197 00:09:31,610 --> 00:09:33,111 A COUPLE MORE SLIDES. 198 00:09:33,111 --> 00:09:33,311 OKAY. 199 00:09:33,311 --> 00:09:34,045 HERE WE GO. 200 00:09:34,045 --> 00:09:34,913 ALL RIGHT. 201 00:09:34,913 --> 00:09:37,248 SO WE HAVE TWO THINGS TO VOTE ON 202 00:09:37,248 --> 00:09:37,449 HERE. 203 00:09:37,449 --> 00:09:41,052 EVERY WINTER WE VOTE ON OUR 204 00:09:41,052 --> 00:09:41,820 COUNCIL OPERATING PROCEDURES, 205 00:09:41,820 --> 00:09:44,356 BECAUSE WE DID NOT MEET FOR THE 206 00:09:44,356 --> 00:09:45,256 OPEN SESSION? 207 00:09:45,256 --> 00:09:47,192 JANUARY WE'RE BRINGING THEM TO 208 00:09:47,192 --> 00:09:47,425 YOU NOW. 209 00:09:47,425 --> 00:09:48,727 THERE WERE NO CHANGES PROPOSED 210 00:09:48,727 --> 00:09:51,830 FOR THIS YEAR BUT WE STILL DO 211 00:09:51,830 --> 00:09:56,167 NEED TO APPROVE THESE OPERATING 212 00:09:56,167 --> 00:09:57,068 PROCEDURES. 213 00:09:57,068 --> 00:10:00,639 SO I'M LOOKING FOR A PROPOSAL TO 214 00:10:00,639 --> 00:10:05,577 APPROVE AND A SECOND, AND ALL IN 215 00:10:05,577 --> 00:10:05,844 FAVOR. 216 00:10:05,844 --> 00:10:07,579 SO EMILY? 217 00:10:07,579 --> 00:10:07,846 OKAY. 218 00:10:07,846 --> 00:10:12,784 I SEE A LOT OF HANDS UP. 219 00:10:12,784 --> 00:10:14,019 ANY OBJECTIONS? 220 00:10:14,019 --> 00:10:15,086 OKAY. 221 00:10:15,086 --> 00:10:15,520 ALL RIGHT. 222 00:10:15,520 --> 00:10:19,157 AND THE MINUTES FROM THE LAST 223 00:10:19,157 --> 00:10:21,126 MEETING, WHICH WAS SEPTEMBER 12 224 00:10:21,126 --> 00:10:25,764 OF 2024, CAN BE FOUND IN THE 225 00:10:25,764 --> 00:10:26,498 ELECTRONIC COUNCIL BOOK. 226 00:10:26,498 --> 00:10:29,334 I'LL HAVE THE HANDS GO DOWN. 227 00:10:29,334 --> 00:10:31,903 AND THEN COME UP AGAIN TO 228 00:10:31,903 --> 00:10:33,071 PROPOSE APPROVAL OF THOSE 229 00:10:33,071 --> 00:10:34,005 MINUTES, A SECOND, AND THEN ALL 230 00:10:34,005 --> 00:10:37,142 IN FAVOR. 231 00:10:37,142 --> 00:10:38,276 THANK YOU. 232 00:10:38,276 --> 00:10:39,444 ANY OPPOSED? 233 00:10:39,444 --> 00:10:39,744 OKAY. 234 00:10:39,744 --> 00:10:40,311 ALL RIGHT. 235 00:10:40,311 --> 00:10:42,280 SO WE'LL MOVE TO THE NEXT SLIDE 236 00:10:42,280 --> 00:10:44,883 WHICH SHOWS THE FUTURE MEETING 237 00:10:44,883 --> 00:10:46,451 DATES OF THIS COUNCIL. 238 00:10:46,451 --> 00:10:49,287 SO, WE HAVE TRIED TO VET THESE 239 00:10:49,287 --> 00:10:50,722 WITH EVERY POSSIBLE CONFLICT 240 00:10:50,722 --> 00:10:53,291 THAT WE KNOW ABOUT. 241 00:10:53,291 --> 00:10:56,828 PLEASE LOOK AT THESE, ENTER THEM 242 00:10:56,828 --> 00:10:58,897 IN YOUR CALENDAR AND LET US KNOW 243 00:10:58,897 --> 00:10:59,731 IF YOU HAVE CONFLICTS. 244 00:10:59,731 --> 00:11:00,265 THANK YOU. 245 00:11:00,265 --> 00:11:01,966 ALL RIGHT. 246 00:11:01,966 --> 00:11:08,406 NOW I WILL MOVE ALONG AND GIVE A 247 00:11:08,406 --> 00:11:09,274 SHORT DIRECTOR'S REPORT. 248 00:11:09,274 --> 00:11:14,112 AND WE'LL GO TO THE NEXT SLIDE. 249 00:11:14,112 --> 00:11:16,614 SO, THERE HAVE BEEN MANY, MANY 250 00:11:16,614 --> 00:11:17,615 CHANGES AT NIH. 251 00:11:17,615 --> 00:11:18,683 AS YOU ALL KNOW. 252 00:11:18,683 --> 00:11:21,152 AND I WANTED TO DRAW YOUR 253 00:11:21,152 --> 00:11:22,987 ATTENTION TO THESE TWO 254 00:11:22,987 --> 00:11:23,722 RESOURCES. 255 00:11:23,722 --> 00:11:26,124 AND BOTH CAN BE ACCESSED WITH 256 00:11:26,124 --> 00:11:31,196 THE LINK OR QR CODE, NIH 257 00:11:31,196 --> 00:11:31,763 GRANTS & FUNDING INFORMATION 258 00:11:31,763 --> 00:11:34,365 STATUS WEB PAGE HAS THE LATEST 259 00:11:34,365 --> 00:11:37,836 STATUS OF CHANGES IMPACTING NIH 260 00:11:37,836 --> 00:11:38,837 GRANTS, ADMINISTRATION, AND 261 00:11:38,837 --> 00:11:41,272 FUNDING. 262 00:11:41,272 --> 00:11:43,775 THEN THERE'S A TRACKING SENDING 263 00:11:43,775 --> 00:11:45,410 WEBSITE THAT PROVIDES 264 00:11:45,410 --> 00:11:49,147 INFORMATION ON NIH'S TERMINATED 265 00:11:49,147 --> 00:11:53,218 GRANTS, ACCESSED THROUGH THE HHS 266 00:11:53,218 --> 00:11:54,986 WEBSITE. 267 00:11:54,986 --> 00:11:56,788 NEXT SLIDE PLEASE. 268 00:11:56,788 --> 00:11:59,758 SO, AS I MENTIONED, WE HAVE HAD 269 00:11:59,758 --> 00:12:03,695 MANY, MANY CHANGES IN ORDER TO 270 00:12:03,695 --> 00:12:06,131 ALIGN NIH PRIORITIES AND FUNDING 271 00:12:06,131 --> 00:12:08,566 MECHANISMS WITH ADMINISTRATION 272 00:12:08,566 --> 00:12:09,167 PRIORITIES. 273 00:12:09,167 --> 00:12:12,003 SO, WE ARE ACCEPTING 274 00:12:12,003 --> 00:12:14,105 APPLICATIONS FOR ACTIVE FUNDING 275 00:12:14,105 --> 00:12:14,839 OPPORTUNITIES, SOME FUNDING 276 00:12:14,839 --> 00:12:16,174 OPPORTUNITIES AS YOU KNOW HAVE 277 00:12:16,174 --> 00:12:18,710 BEEN CLOSED AND OTHERS HAVE BEEN 278 00:12:18,710 --> 00:12:21,780 UPDATED IN ORDER TO ALIGN WITH 279 00:12:21,780 --> 00:12:23,515 AGENCY PRIORITIES. 280 00:12:23,515 --> 00:12:26,684 APPLICANTS ARE ENCOURAGED TO 281 00:12:26,684 --> 00:12:28,119 CAREFULLY RE-READ FUNDING 282 00:12:28,119 --> 00:12:29,120 OPPORTUNITIES TO NOTE ANY 283 00:12:29,120 --> 00:12:31,623 CHANGES THAT HAVE BEEN MADE 284 00:12:31,623 --> 00:12:33,324 PRIOR TO ANY SUBMISSIONS SO THAT 285 00:12:33,324 --> 00:12:36,761 THEY CAN ADJUST THEIR 286 00:12:36,761 --> 00:12:38,563 APPLICATIONS ACCORDINGLY. 287 00:12:38,563 --> 00:12:40,598 WE NO LONGER REQUIRE AND WILL 288 00:12:40,598 --> 00:12:43,768 NOT REVIEW PLANS FOR ENHANCING 289 00:12:43,768 --> 00:12:47,806 DIVERSE PERSPECTIVES OR THE PEDP 290 00:12:47,806 --> 00:12:49,474 PLANS, CONFERENCE GRANTS, 291 00:12:49,474 --> 00:12:53,211 DIVERSITY PLANS, OR RECRUITMENT 292 00:12:53,211 --> 00:12:56,781 PLANS TO ENHANCE DIVERSITY. 293 00:12:56,781 --> 00:12:58,249 FEDERAL REGISTER NOTICES AND 294 00:12:58,249 --> 00:12:59,751 MEETINGS ARE CURRENTLY ONGOING 295 00:12:59,751 --> 00:13:03,788 FOR SCIENTIFIC REVIEW GROUPS AND 296 00:13:03,788 --> 00:13:04,589 STUDY SECTIONS. 297 00:13:04,589 --> 00:13:06,324 AND FEDERAL REGISTER NOTICES 298 00:13:06,324 --> 00:13:08,426 HAVE RESUMED FOR NATIONAL 299 00:13:08,426 --> 00:13:09,260 ADVISORY COUNCIL MEETINGS AND 300 00:13:09,260 --> 00:13:09,527 BOARDS. 301 00:13:09,527 --> 00:13:13,464 AND THAT'S WHY WE CAN HAVE THESE 302 00:13:13,464 --> 00:13:15,066 MEETINGS TODAY AND TOMORROW. 303 00:13:15,066 --> 00:13:18,770 FOR AWARDS WE'RE ISSUING AWARDS 304 00:13:18,770 --> 00:13:22,073 FOR COMPETING, NON-COMPETING 305 00:13:22,073 --> 00:13:22,974 CONTINUATION, AND ADMINISTRATIVE 306 00:13:22,974 --> 00:13:24,609 SUPPLEMENTS USING PREVIOUSLY 307 00:13:24,609 --> 00:13:26,177 APPROVED NEGOTIATED INDIRECT 308 00:13:26,177 --> 00:13:28,580 COST RATES, EXCEPT FOR AWARDS 309 00:13:28,580 --> 00:13:34,118 UNDER WHICH F & A COSTS ARE 310 00:13:34,118 --> 00:13:35,653 REIMBURSED AT FIX THE RATES. 311 00:13:35,653 --> 00:13:38,423 THAT'S AN UPDATE ON GRANTS. 312 00:13:38,423 --> 00:13:38,957 NEXT SLIDE. 313 00:13:38,957 --> 00:13:42,927 I WANT TO GIVE A WARM, WARM 314 00:13:42,927 --> 00:13:45,263 WELCOME FROM NIDCD TO 18th 315 00:13:45,263 --> 00:13:47,932 DIRECTOR OF THE NATIONAL 316 00:13:47,932 --> 00:13:51,336 INSTITUTES OF HEALTH, DR. JAY 317 00:13:51,336 --> 00:13:51,669 BHATTACHARYA. 318 00:13:51,669 --> 00:13:54,205 DR. BHATTACHARYA ASSUMED THIS 319 00:13:54,205 --> 00:13:56,107 OFFICE ON APRIL 1. 320 00:13:56,107 --> 00:13:56,975 HE PREVIOUSLY WAS A TENURED 321 00:13:56,975 --> 00:13:59,611 PROFESSOR IN THE MEDICAL SCHOOL 322 00:13:59,611 --> 00:14:01,045 AT STANFORD UNIVERSITY IN 323 00:14:01,045 --> 00:14:01,980 CALIFORNIA. 324 00:14:01,980 --> 00:14:03,381 HIS RESEARCH HAS BEEN FUNDED 325 00:14:03,381 --> 00:14:07,619 PRIMARILY BY THE NATIONAL NATIL 326 00:14:07,619 --> 00:14:08,620 INSTITUTE ON AGING FOCUSED ON 327 00:14:08,620 --> 00:14:11,356 POPULATION AGING AND CHRONIC 328 00:14:11,356 --> 00:14:12,590 DISEASE, PARTICULARLY ON THE 329 00:14:12,590 --> 00:14:15,126 HEALTH AND WELL-BEING OF 330 00:14:15,126 --> 00:14:16,494 VULNERABLE POPULATIONS. 331 00:14:16,494 --> 00:14:20,164 HIS APPROACH TO LEADING NIH IS 332 00:14:20,164 --> 00:14:20,632 TO ENCOURAGE DIFFERENT 333 00:14:20,632 --> 00:14:22,200 PERSPECTIVES AS PART OF HIS 334 00:14:22,200 --> 00:14:24,402 LARGER MISSION TO RESTORE PUBLIC 335 00:14:24,402 --> 00:14:25,837 TRUST IN SCIENCE. 336 00:14:25,837 --> 00:14:29,874 AGAIN, WELCOME TO DR. 337 00:14:29,874 --> 00:14:31,709 BHATTACHARYA. 338 00:14:31,709 --> 00:14:35,880 AND THE NEXT SLIDE IS BOTH TO 339 00:14:35,880 --> 00:14:39,183 THANK DR. MATT MEMOLI, WHO 340 00:14:39,183 --> 00:14:40,818 SERVED AS ACTING DIRECTOR 341 00:14:40,818 --> 00:14:43,454 JANUARY 22 TO MARCH 31, THE DAY 342 00:14:43,454 --> 00:14:45,256 BEFORE DR. BHATTACHARYA ARRIVED, 343 00:14:45,256 --> 00:14:47,191 AND HE HAS STAYED IN THE OFFICE 344 00:14:47,191 --> 00:14:50,929 OF THE DIRECTOR AT NIH TO SERVE 345 00:14:50,929 --> 00:14:52,664 AS PRINCIPAL DEPUTY DIRECTOR, 346 00:14:52,664 --> 00:14:55,600 WHICH IS A ROLE THAT PREVIOUSLY 347 00:14:55,600 --> 00:14:59,771 DR. LARRY TABAK SERVED IN FOR 348 00:14:59,771 --> 00:15:01,406 MANY YEARS. 349 00:15:01,406 --> 00:15:06,110 SO, HAS WORKED AT NIH FOR 20 350 00:15:06,110 --> 00:15:07,078 YEARS, RECENTLY DIRECTOR OF 351 00:15:07,078 --> 00:15:09,013 CLINICAL STUDIES UNIT IN THE 352 00:15:09,013 --> 00:15:09,514 LABORATORY OF INFECTIOUS 353 00:15:09,514 --> 00:15:14,352 DISEASES, PART OF THE NIH'S 354 00:15:14,352 --> 00:15:16,054 NATIONAL INSTITUTE ON ALLERGY 355 00:15:16,054 --> 00:15:16,921 AND INFECTIOUS DISEASE, 356 00:15:16,921 --> 00:15:19,357 PREVIOUSLY STAFF CLINICIAN IN 357 00:15:19,357 --> 00:15:21,826 THE SAME LAB, AND NOW HAS MOVED 358 00:15:21,826 --> 00:15:24,862 TO THIS POSITION SO WE VERY MUCH 359 00:15:24,862 --> 00:15:26,898 APPRECIATE HIS EFFORTS ON OUR 360 00:15:26,898 --> 00:15:30,234 BEHALF AS WELL. 361 00:15:30,234 --> 00:15:30,568 OKAY. 362 00:15:30,568 --> 00:15:30,868 NEXT SLIDE. 363 00:15:30,868 --> 00:15:36,207 SO, THIS IS SOME VERY, VERY 364 00:15:36,207 --> 00:15:38,009 HAPPY NEWS. 365 00:15:38,009 --> 00:15:41,546 PRESIDENT BIDEN HONORED TWO 366 00:15:41,546 --> 00:15:43,081 NIDCD-FUNDED EARLY CAREER 367 00:15:43,081 --> 00:15:46,351 SCIENTISTS, AND THESE SCIENTISTS 368 00:15:46,351 --> 00:15:48,319 WERE AWARDED THE PRESIDENTIAL 369 00:15:48,319 --> 00:15:49,420 EARLY CAREER AWARD FOR 370 00:15:49,420 --> 00:15:50,755 SCIENTISTS AND ENGINEERS, THIS 371 00:15:50,755 --> 00:15:55,660 IS A PROGRAM CALLED PECASE, THE 372 00:15:55,660 --> 00:15:57,395 HIGHEST HONOR BESTOWED BY THE 373 00:15:57,395 --> 00:15:59,030 U.S. GOVERNMENT ON OUTSTANDING 374 00:15:59,030 --> 00:15:59,697 SCIENTISTS AND ENGINEERS EARLY 375 00:15:59,697 --> 00:16:00,431 IN THEIR CAREERS. 376 00:16:00,431 --> 00:16:04,168 AND JUST A LITTLE BIT OF 377 00:16:04,168 --> 00:16:05,837 BACKGROUND ON THE PROGRAM, THIS 378 00:16:05,837 --> 00:16:08,473 WAS ESTABLISHED BY PRESIDENT 379 00:16:08,473 --> 00:16:10,641 CLINTON IN 1996, TO RECOGNIZE 380 00:16:10,641 --> 00:16:13,044 SCIENTISTS AND ENGINEERS WHO 381 00:16:13,044 --> 00:16:15,146 SHOW EXCEPTIONAL POTENTIAL FOR 382 00:16:15,146 --> 00:16:16,547 LEADERSHIP EARLY IN THEIR 383 00:16:16,547 --> 00:16:19,317 RESEARCH CAREERS. 384 00:16:19,317 --> 00:16:21,386 THE AWARD RECOGNIZES INNOVATIVE 385 00:16:21,386 --> 00:16:23,921 AND FAR-REACHING DEVELOPMENT IN 386 00:16:23,921 --> 00:16:25,757 SCIENCE AND TECHNOLOGY, EXPANDS 387 00:16:25,757 --> 00:16:30,161 AWARENESS OF CAREERS IN SCIENCE 388 00:16:30,161 --> 00:16:32,163 AND ENGINEERING, RECOGNIZES 389 00:16:32,163 --> 00:16:34,665 SCIENTIFIC MISSIONS OF 390 00:16:34,665 --> 00:16:36,300 PARTICIPATING AGENCIES, ENHANCES 391 00:16:36,300 --> 00:16:38,803 CONNECTIONS BETWEEN RESEARCH AND 392 00:16:38,803 --> 00:16:39,904 IMPACTS ON SOCIETY AND 393 00:16:39,904 --> 00:16:41,005 HIGHLIGHTS IMPORTANCE OF SCIENCE 394 00:16:41,005 --> 00:16:42,974 AND TECHNOLOGY FOR OUR NATION'S 395 00:16:42,974 --> 00:16:43,608 FUTURE. 396 00:16:43,608 --> 00:16:48,012 SO WE WERE THRILLED TO HAVE TWO 397 00:16:48,012 --> 00:16:49,647 NIDCD GRANT RECIPIENTS RECEIVE 398 00:16:49,647 --> 00:16:52,717 THIS AWARD, DR. MATT BUSH, WHO 399 00:16:52,717 --> 00:16:58,856 WORKS ON ACCESS TO HEARING 400 00:16:58,856 --> 00:17:04,095 HEALTH CARE IN APPALACHIA, AND 401 00:17:04,095 --> 00:17:10,034 ANNE TAKESIAN, ELECTRO CORTEX 402 00:17:10,034 --> 00:17:10,601 PHYSIOLOGY. 403 00:17:10,601 --> 00:17:11,436 CONGRATULATIONS TO BOTH 404 00:17:11,436 --> 00:17:12,737 SCIENTISTS. 405 00:17:12,737 --> 00:17:16,240 ANOTHER BIT OF EXCITING NEWS IS 406 00:17:16,240 --> 00:17:18,976 THAT THE NATIONAL ACADEMIES OF 407 00:17:18,976 --> 00:17:20,945 SCIENCE AND, ENGINEERING, AND 408 00:17:20,945 --> 00:17:23,514 MEDICINE RECENTLY RELEASED A 409 00:17:23,514 --> 00:17:25,917 REPORT MEASURING THE OUTCOMES IN 410 00:17:25,917 --> 00:17:26,918 ADULT HEARING HEALTH 411 00:17:26,918 --> 00:17:28,519 INTERVENTIONS. 412 00:17:28,519 --> 00:17:32,623 THIS IS A CONSENSUS STUDY THAT 413 00:17:32,623 --> 00:17:35,526 WAS COMMISSIONED PRIMARILY BY 414 00:17:35,526 --> 00:17:37,428 NIDCD WITH PARTNERSHIPS WITH THE 415 00:17:37,428 --> 00:17:41,766 CENTERS FOR DISEASE CONTROL AND 416 00:17:41,766 --> 00:17:42,333 PREVENTION, DEFENSE HEALTH 417 00:17:42,333 --> 00:17:43,634 AGENCY, DEPARTMENT OF VETERANS 418 00:17:43,634 --> 00:17:46,037 AFFAIRS, AND NATIONAL INSTITUTE 419 00:17:46,037 --> 00:17:46,304 ON AGING. 420 00:17:46,304 --> 00:17:49,207 AND THE GOAL THAT WE WANTED TO 421 00:17:49,207 --> 00:17:52,176 ACHIEVE IS TO ESTABLISH A 422 00:17:52,176 --> 00:17:54,378 CONSENSUS ON MEANINGFUL OUTCOME 423 00:17:54,378 --> 00:17:55,913 MEASURES IN ADULT HEARING HEALTH 424 00:17:55,913 --> 00:17:56,347 CARE. 425 00:17:56,347 --> 00:17:58,850 WE THINK THAT THIS IS A 426 00:17:58,850 --> 00:18:00,384 MILESTONE FOR THE FIELD, AND 427 00:18:00,384 --> 00:18:03,554 HOPE WILL SET THE STANDARD FOR 428 00:18:03,554 --> 00:18:05,423 THOSE ENGAGED IN HEARING-RELATED 429 00:18:05,423 --> 00:18:08,192 RESEARCH AND IN CLINICAL 430 00:18:08,192 --> 00:18:08,459 PRACTICE. 431 00:18:08,459 --> 00:18:09,961 SO, THIS REPORT WAS PUBLISHED 432 00:18:09,961 --> 00:18:11,963 YESTERDAY, ON WEDNESDAY, MAY 433 00:18:11,963 --> 00:18:15,700 7th, AND IS NOW AVAILABLE TO 434 00:18:15,700 --> 00:18:17,468 DOWNLOAD FREE OF CHARGE, A 435 00:18:17,468 --> 00:18:19,570 PUBLIC SEMINAR WILL BE HELD NEXT 436 00:18:19,570 --> 00:18:22,140 WEEK ON MAY 12, MONDAY, AT 3 437 00:18:22,140 --> 00:18:22,373 P.M. 438 00:18:22,373 --> 00:18:24,475 AND THERE ARE MEMBERS OF THE 439 00:18:24,475 --> 00:18:25,576 REPORT COMMITTEE THAT WILL SPEAK 440 00:18:25,576 --> 00:18:28,312 AND ANSWER QUESTIONS FROM THE 441 00:18:28,312 --> 00:18:29,080 AUDIENCE. 442 00:18:29,080 --> 00:18:31,482 THAT WILL ALSO BE RECORDED AND 443 00:18:31,482 --> 00:18:33,451 AVAILABLE ON THEIR WEBSITE IF 444 00:18:33,451 --> 00:18:34,652 YOU'RE NOT AVAILABLE AT THAT 445 00:18:34,652 --> 00:18:37,488 TIME AND WOULD LIKE TO ACCESS 446 00:18:37,488 --> 00:18:38,589 THE RECORDING. 447 00:18:38,589 --> 00:18:41,425 DR. KELLY KING HAS BEEN THE LEAD 448 00:18:41,425 --> 00:18:43,728 ON THIS FROM NIDCD, AND WE WILL 449 00:18:43,728 --> 00:18:47,131 ASK HER TO SPEAK MORE ABOUT THIS 450 00:18:47,131 --> 00:18:50,735 IN FURTHER NIDCD PLANS AT A 451 00:18:50,735 --> 00:18:51,969 FUTURE COUNCIL MEETING. 452 00:18:51,969 --> 00:18:53,905 ALL RIGHT. 453 00:18:53,905 --> 00:18:55,606 AND THE LAST ORDER OF BUSINESS 454 00:18:55,606 --> 00:18:58,476 STARTS ON THE NEXT SLIDE, FOR 455 00:18:58,476 --> 00:19:00,511 THE NEXT SEVERAL SLIDES. 456 00:19:00,511 --> 00:19:04,415 AND THAT IS THAT I WOULD LIKE TO 457 00:19:04,415 --> 00:19:07,485 CHARGE, REQUEST AND CHARGE, AN 458 00:19:07,485 --> 00:19:08,953 NIDCD COUNCIL CLINICAL TRIALS 459 00:19:08,953 --> 00:19:09,720 WORKING GROUP. 460 00:19:09,720 --> 00:19:13,057 SO FROM TIME TO TIME, WE SEEK TO 461 00:19:13,057 --> 00:19:14,358 LEVERAGE THE EXPERTISE AND 462 00:19:14,358 --> 00:19:15,760 PERSPECTIVE OF MEMBERS OF OUR 463 00:19:15,760 --> 00:19:18,829 COUNCIL AND MEMBERS OF OUR 464 00:19:18,829 --> 00:19:20,698 RESEARCH COMMUNITY TO ADDRESS 465 00:19:20,698 --> 00:19:22,633 CHALLENGES OF THE INSTITUTE. 466 00:19:22,633 --> 00:19:24,869 SO, TODAY I WANT TO PROPOSE THIS 467 00:19:24,869 --> 00:19:26,971 WORKING GROUP TO ANSWER 468 00:19:26,971 --> 00:19:30,441 IMPORTANT QUESTIONS ABOUT HOW WE 469 00:19:30,441 --> 00:19:30,975 SUPPORT CLINICAL TRIALS AT 470 00:19:30,975 --> 00:19:31,776 NIDCD. 471 00:19:31,776 --> 00:19:35,046 THIS IS A TOPIC OF BROAD 472 00:19:35,046 --> 00:19:36,247 CONSIDERATION AND INTEREST 473 00:19:36,247 --> 00:19:39,116 ACROSS NIH AT LARGE, AND SO IT'S 474 00:19:39,116 --> 00:19:41,252 A TOPIC THAT'S NOT ONLY 475 00:19:41,252 --> 00:19:42,753 CONSIDERED WITHIN OUR INSTITUTE 476 00:19:42,753 --> 00:19:46,357 BUT ALSO WITHIN THE AGENCY AT 477 00:19:46,357 --> 00:19:46,924 LARGE. 478 00:19:46,924 --> 00:19:49,961 I'VE ASKED DR. JAY PICARIRLO TO 479 00:19:49,961 --> 00:19:51,896 CO-CHAIR AND WE'LL BE WORKING 480 00:19:51,896 --> 00:19:54,498 TOGETHER OVER THE COMING WEEKS 481 00:19:54,498 --> 00:19:56,100 TO ASSEMBLE AN EXPERT PANEL TO 482 00:19:56,100 --> 00:19:57,735 CONDUCT THIS WORK. 483 00:19:57,735 --> 00:19:59,704 THE GROUP WILL INTERVIEW A 484 00:19:59,704 --> 00:20:01,038 VARIETY OF INDIVIDUALS WHO HAVE 485 00:20:01,038 --> 00:20:02,773 INTEREST AND EXPERTISE IN THIS 486 00:20:02,773 --> 00:20:05,843 AREA OF OUR PORTFOLIO AND WILL 487 00:20:05,843 --> 00:20:06,744 ISSUE A PUBLIC REPORT. 488 00:20:06,744 --> 00:20:12,416 THE CHARGE TO THE GROUP IS SHOWN 489 00:20:12,416 --> 00:20:12,683 HERE. 490 00:20:12,683 --> 00:20:14,619 HOW CAN WE EXPAND AND SUPPORT 491 00:20:14,619 --> 00:20:17,021 OUR APPLICANT POOL, WE WOULD 492 00:20:17,021 --> 00:20:19,757 LIKE TO STIMULATE INTEREST AND 493 00:20:19,757 --> 00:20:21,659 EXPERTISE IN THE GROUP OF 494 00:20:21,659 --> 00:20:25,563 INVESTIGATORS WHO ARE DOING WORK 495 00:20:25,563 --> 00:20:28,099 IN OUR MISSION AREAS SO THEY CAN 496 00:20:28,099 --> 00:20:30,835 SUBMIT AND COMPLETE SUCCESSFUL 497 00:20:30,835 --> 00:20:31,869 CLINICAL TRIALS. 498 00:20:31,869 --> 00:20:33,871 SECOND, NIDCD FULFILLING NEEDS 499 00:20:33,871 --> 00:20:35,906 OF RESEARCH COMMUNITY AND 500 00:20:35,906 --> 00:20:38,242 STAKEHOLDERS, WHAT IS OUR 501 00:20:38,242 --> 00:20:39,143 STRATEGIC DIRECTION, WHAT 502 00:20:39,143 --> 00:20:43,781 MECHANISMS DO WE HAVE TO SUPPORT 503 00:20:43,781 --> 00:20:44,515 CLINICAL TRIALS WITHIN NIDCD, 504 00:20:44,515 --> 00:20:47,685 AND HOW CAN WE DO THIS BETTER? 505 00:20:47,685 --> 00:20:49,820 AND THEN THIRD, ARE WE 506 00:20:49,820 --> 00:20:54,191 LEVERAGING AVAILABLE RESOURCES 507 00:20:54,191 --> 00:20:55,960 OPTIMALLY, AND WHAT RESOURCES 508 00:20:55,960 --> 00:20:57,461 ARE NEEDED BY INVESTIGATORS WE 509 00:20:57,461 --> 00:21:01,399 MIGHT PROVIDE THROUGH OUR OWN 510 00:21:01,399 --> 00:21:03,067 EFFORTS OR THROUGH RESEARCH 511 00:21:03,067 --> 00:21:05,770 ORGANIZATIONS, AS WELL AS NIH 512 00:21:05,770 --> 00:21:07,972 RESOURCES SUCH AS IN NCATS AND 513 00:21:07,972 --> 00:21:11,442 AS YOU WILL RECALL HEARING FROM 514 00:21:11,442 --> 00:21:13,077 DR. JONI RUTTER ABOUT THE 515 00:21:13,077 --> 00:21:17,882 PROGRAM THAT'S -- PROGRAMS THAT 516 00:21:17,882 --> 00:21:19,650 THEY HAVE AVAILABLE IN NCATS. 517 00:21:19,650 --> 00:21:22,053 NEXT SLIDE. 518 00:21:22,053 --> 00:21:25,356 LAST MAY, DR. TRENDILY GAVE A 519 00:21:25,356 --> 00:21:27,458 PRESENTATION AT COUNCIL MEETING, 520 00:21:27,458 --> 00:21:30,094 GIVING INFORMATION ABOUT OUR 521 00:21:30,094 --> 00:21:31,395 CURRENT CLINICAL TRIAL 522 00:21:31,395 --> 00:21:31,729 PORTFOLIO. 523 00:21:31,729 --> 00:21:34,699 NIDCD CURRENTLY FUNDS THE 524 00:21:34,699 --> 00:21:37,902 MAJORITY OF CLINICAL TRIALS 525 00:21:37,902 --> 00:21:40,204 THROUGH R01 AND U01 MECHANISMS. 526 00:21:40,204 --> 00:21:42,907 LOWER RISK CLINICAL TRIALS 527 00:21:42,907 --> 00:21:45,576 UTILIZE THE R01 MECHANISM, AND 528 00:21:45,576 --> 00:21:47,845 IN THAT CASE THE PRINCIPAL 529 00:21:47,845 --> 00:21:49,246 INVESTIGATORS INTERACT ONLY WITH 530 00:21:49,246 --> 00:21:51,115 THE PROGRAM OFFICERS AND NOT 531 00:21:51,115 --> 00:21:53,184 WITH THE CLINICAL TRIALS OFFICE, 532 00:21:53,184 --> 00:21:57,922 OR THE MEDICAL OFFICERS. 533 00:21:57,922 --> 00:21:58,889 THE U01 MECHANISM FUNDS HIGH 534 00:21:58,889 --> 00:22:00,524 RISK CLINICAL TRIALS, AND THESE 535 00:22:00,524 --> 00:22:03,094 ARE THE TRIALS SUPPORTED THROUGH 536 00:22:03,094 --> 00:22:03,928 OUR CLINICAL TRIAL OFFICE, AND 537 00:22:03,928 --> 00:22:08,632 I'LL DESCRIBE THAT OFFICE IN A 538 00:22:08,632 --> 00:22:09,166 MOMENT. 539 00:22:09,166 --> 00:22:10,434 SO, NIDCD CONSIDERS RISK IN 540 00:22:10,434 --> 00:22:13,771 TERMS OF COMPLEXITY OF THE 541 00:22:13,771 --> 00:22:15,639 TRIAL, SAFETY CONSIDERATIONS, 542 00:22:15,639 --> 00:22:16,941 IMPACT, AND FISCAL INVESTMENT. 543 00:22:16,941 --> 00:22:19,143 SO, AS YOU CAN SEE, THE GREAT 544 00:22:19,143 --> 00:22:21,545 MAJORITY OF TRIALS ARE FUNDED 545 00:22:21,545 --> 00:22:23,080 THROUGH THE R01 MECHANISM, AND 546 00:22:23,080 --> 00:22:25,583 SO THAT'S SHOWN IN BLUE BARS. 547 00:22:25,583 --> 00:22:27,218 BROKEN DOWN BY OUR MISSION 548 00:22:27,218 --> 00:22:28,753 AREAS. 549 00:22:28,753 --> 00:22:34,458 SO WE HAVE MANY MORE R01-FUNDED 550 00:22:34,458 --> 00:22:35,593 CLINICAL TRIALS THAN U01s 551 00:22:35,593 --> 00:22:38,529 SHOWN IN THE ORANGE BOXES. 552 00:22:38,529 --> 00:22:40,498 I'LL MENTION ALSO THAT SOME OF 553 00:22:40,498 --> 00:22:47,371 YOU ARE AWARE OF AN NIH-DESIGNED 554 00:22:47,371 --> 00:22:50,441 CATEGORY, BASIC EXPERIMENTAL 555 00:22:50,441 --> 00:22:52,643 STUDIES INVOLVING HUMANS, BESH, 556 00:22:52,643 --> 00:22:53,844 NOT INTERVENTIONAL TRIALS, AND 557 00:22:53,844 --> 00:22:55,579 THEY ARE ALSO INCLUDED IN THIS 558 00:22:55,579 --> 00:22:59,517 NUMBER OF LOWER RISK R01s. 559 00:22:59,517 --> 00:23:00,651 NEXT SLIDE. 560 00:23:00,651 --> 00:23:03,187 THIS SHOWS THE CHARACTERISTICS 561 00:23:03,187 --> 00:23:06,991 OF THE U01 CLINICAL TRIALS, THE 562 00:23:06,991 --> 00:23:07,992 TRIALS THAT WE'LL BE CONSIDERING 563 00:23:07,992 --> 00:23:09,326 IN THE WORKING GROUP BECAUSE 564 00:23:09,326 --> 00:23:10,494 THEY ARE THE ONES SUPPORTED BY 565 00:23:10,494 --> 00:23:13,764 OUR CLINICAL TRIALS OFFICE. 566 00:23:13,764 --> 00:23:19,036 AND SO THEY MAY HAVE A FEW OF 567 00:23:19,036 --> 00:23:21,505 THESE FEATURES, ONE REQUIRES FDA 568 00:23:21,505 --> 00:23:24,442 OVERSIGHT, SUCH AS THOSE THAT 569 00:23:24,442 --> 00:23:26,744 REQUIRE AN INVESTIGATIONAL NEW 570 00:23:26,744 --> 00:23:29,814 DRUG, IND, OR INVESTIGATIONAL 571 00:23:29,814 --> 00:23:30,848 DEVICE EXEMPTION, IDE, 572 00:23:30,848 --> 00:23:31,248 APPLICATION. 573 00:23:31,248 --> 00:23:34,318 THEY MAY HAVE HIGHER RISKS TO 574 00:23:34,318 --> 00:23:35,820 PARTICIPATE, PARTICULARLY IN OUR 575 00:23:35,820 --> 00:23:39,623 PORTFOLIO THEY MAY INVOLVE A 576 00:23:39,623 --> 00:23:41,959 SURGICAL INTERVENTION. 577 00:23:41,959 --> 00:23:43,794 THEY COULD BE A PIVOTAL CLINICAL 578 00:23:43,794 --> 00:23:49,500 TRIAL, SUCH AS BE A NIH DEFINED 579 00:23:49,500 --> 00:23:52,703 PHASE 3 CLINICAL TRIAL FOR 580 00:23:52,703 --> 00:23:54,138 SAFETY AND EFFECTIVENESS OF NEW 581 00:23:54,138 --> 00:23:55,973 PROPOSED TREATMENT AND THIS 582 00:23:55,973 --> 00:23:58,042 INCLUDES APPLICATIONS THAT 583 00:23:58,042 --> 00:24:04,748 EXCEED THE ANNUAL DIRECT COST OF 584 00:24:04,748 --> 00:24:06,617 $700,000. 585 00:24:06,617 --> 00:24:07,818 NEXT SLIDE. 586 00:24:07,818 --> 00:24:13,090 FOR THESE THE TOTAL NUMBER OF 587 00:24:13,090 --> 00:24:14,558 PROJECTS, NIDCD SUPPORTED U01 588 00:24:14,558 --> 00:24:15,693 CLINICAL TRIALS. 589 00:24:15,693 --> 00:24:17,094 OVER THE LAST TEN YEARS. 590 00:24:17,094 --> 00:24:20,264 SO YOU CAN SEE THAT IN 2024, 591 00:24:20,264 --> 00:24:23,667 WE'RE AT 13 TRIALS. 592 00:24:23,667 --> 00:24:26,237 THIS IS DOWN SLIGHTLY. 593 00:24:26,237 --> 00:24:29,540 A CONCERNING ISSUE IS THAT WE'RE 594 00:24:29,540 --> 00:24:34,111 DUE TO WRAP UP FOUR U01s THIS 595 00:24:34,111 --> 00:24:36,213 FISCAL YEAR, SO THAT NUMBER WILL 596 00:24:36,213 --> 00:24:37,414 GO DOWN. 597 00:24:37,414 --> 00:24:40,050 AND WE DO NOT HAVE U01s IN THE 598 00:24:40,050 --> 00:24:42,219 PIPELINE AT THIS TIME. 599 00:24:42,219 --> 00:24:47,491 SO THE LAST SUCCESSFUL. WAS 600 00:24:47,491 --> 00:24:49,860 SUBMITTED IN JUNE OF 2022, 601 00:24:49,860 --> 00:24:51,095 AWARDED IN AUGUST OF 2023. 602 00:24:51,095 --> 00:24:53,831 SINCE THEN THERE HAVE BEEN SEVEN 603 00:24:53,831 --> 00:24:55,599 APPLICATIONS, AND NONE OF THESE 604 00:24:55,599 --> 00:24:58,402 HAVE SCORED WELL ENOUGH TO BE 605 00:24:58,402 --> 00:24:58,636 FUNDED. 606 00:24:58,636 --> 00:25:01,906 SO, THAT IS OF CONCERN TO ME AND 607 00:25:01,906 --> 00:25:09,446 TO OUR STAFF. 608 00:25:09,446 --> 00:25:11,248 NEXT SLIDE PLEASE. 609 00:25:11,248 --> 00:25:13,083 THIS SHOWS NIDCD-SUPPORTED 610 00:25:13,083 --> 00:25:14,718 CLINICAL TRIALS BY AREA, BY 611 00:25:14,718 --> 00:25:15,819 MISSION AREA, OVER THE LAST TEN 612 00:25:15,819 --> 00:25:18,455 YEARS SO YOU CAN SEE IF YOU LOOK 613 00:25:18,455 --> 00:25:20,824 AT 2015 MOST OF THESE TRIALS 614 00:25:20,824 --> 00:25:23,027 WERE IN HEARING AND BALANCE. 615 00:25:23,027 --> 00:25:26,130 AND OVER THE INTERVENING YEARS, 616 00:25:26,130 --> 00:25:28,532 THIS HAS BECOME MORE BALANCED 617 00:25:28,532 --> 00:25:30,267 BETWEEN THE VOICE, SPEECH AND 618 00:25:30,267 --> 00:25:33,370 LANGUAGE PORTFOLIO AND THE 619 00:25:33,370 --> 00:25:34,972 HEARING AND BALANCE PORTFOLIO, 620 00:25:34,972 --> 00:25:38,709 SO THAT VOICE, SPEECH AND 621 00:25:38,709 --> 00:25:40,210 LANGUAGE DOMINATE, STILL WITH 622 00:25:40,210 --> 00:25:44,481 JUST ONE TRIAL IN THE CONSENSUS 623 00:25:44,481 --> 00:25:45,482 SO THE PORTFOLIO CHANGED OVER 624 00:25:45,482 --> 00:25:47,651 TIME IN THAT WAY. 625 00:25:47,651 --> 00:25:47,952 NEXT SLIDE. 626 00:25:47,952 --> 00:25:49,553 I THINK THIS IS OF HAVE BECAUSE 627 00:25:49,553 --> 00:25:52,389 IT GIVES A LITTLE BIT OF INSIGHT 628 00:25:52,389 --> 00:25:54,658 INTO THE KINDS OF U01 CLINICAL 629 00:25:54,658 --> 00:25:57,094 TRIALS THAT WE FUND. 630 00:25:57,094 --> 00:26:00,130 SO, THIS IS SHOWING DIFFERENCES 631 00:26:00,130 --> 00:26:02,132 BY TYPE OF INTERVENTION, 632 00:26:02,132 --> 00:26:04,535 INCLUDING DEVICE TRIALS, DRUG 633 00:26:04,535 --> 00:26:05,970 TRIALS, BEHAVIORAL TRIALS, AND 634 00:26:05,970 --> 00:26:06,937 NUTRITIONAL TRIALS. 635 00:26:06,937 --> 00:26:10,808 AND YOU CAN SEE THAT REALLY OVER 636 00:26:10,808 --> 00:26:13,010 THE WHOLE TIME WE'VE BEEN 637 00:26:13,010 --> 00:26:13,944 FUNDING U01 CLINICAL TRIALS, AT 638 00:26:13,944 --> 00:26:18,115 LEAST FOR THE PAST TEN YEARS, 639 00:26:18,115 --> 00:26:19,416 THAT DEVICE TRIALS HAVE 640 00:26:19,416 --> 00:26:22,419 PREDOMINATED, THE BLUE BARS YOU 641 00:26:22,419 --> 00:26:23,387 SEE THERE. 642 00:26:23,387 --> 00:26:26,256 AND, AGAIN, SHOWS TOTAL OF 13 643 00:26:26,256 --> 00:26:27,658 TRIALS WITH TWO BEHAVIORAL, 644 00:26:27,658 --> 00:26:30,060 EIGHT DEVICE, TWO DRUG TRIALS, 645 00:26:30,060 --> 00:26:31,328 ONE NUTRITIONAL TRIAL. 646 00:26:31,328 --> 00:26:34,031 SO THE FACT THAT THESE ARE 647 00:26:34,031 --> 00:26:38,936 MOSTLY DEVICE RELATED CERTAINLY 648 00:26:38,936 --> 00:26:42,640 ADDS TO THE RISK AND 649 00:26:42,640 --> 00:26:43,307 COMPLEXITIES. 650 00:26:43,307 --> 00:26:43,607 NEXT SLIDE. 651 00:26:43,607 --> 00:26:45,542 THIS IS THE MAKEUP OF OUR 652 00:26:45,542 --> 00:26:47,811 CLINICAL TRIALS OFFICE. 653 00:26:47,811 --> 00:26:52,049 WE HAVE TWO FULL-TIME MEDICAL 654 00:26:52,049 --> 00:26:54,618 OFFICERS, DR. TRINEDLY AND 655 00:26:54,618 --> 00:26:56,220 JABARI, PRIMARY POINTS OF 656 00:26:56,220 --> 00:26:58,455 CONTACT FOR MOST CLINICAL 657 00:26:58,455 --> 00:27:00,057 TRIAL-RELATED QUESTIONS. 658 00:27:00,057 --> 00:27:02,326 AND THEY ALSO HAVE A VARIETY OF 659 00:27:02,326 --> 00:27:04,628 FUNCTIONS THAT I THINK I'LL SHOW 660 00:27:04,628 --> 00:27:08,565 MORE IN THE NEXT SLIDE. 661 00:27:08,565 --> 00:27:10,868 WE HAVE A CLINICAL TRIALS 662 00:27:10,868 --> 00:27:13,971 OFFICER, DR. MCNAMARA, AND SHE'S 663 00:27:13,971 --> 00:27:17,274 THE PRIMARY CONTRACT OFFICER FOR 664 00:27:17,274 --> 00:27:19,109 NIDCD CLINICAL TRIALS, SHE ALSO 665 00:27:19,109 --> 00:27:21,945 PROVIDES EXPERTISE IN HUMAN 666 00:27:21,945 --> 00:27:27,418 SUBJECTS, INFORMED CONSENT, 667 00:27:27,418 --> 00:27:29,286 CONFLICTS OF INTEREST. 668 00:27:29,286 --> 00:27:30,587 CLINICAL TRIAL STATISTICIAN 669 00:27:30,587 --> 00:27:31,455 PROVIDES STATISTICAL EXPERTISE, 670 00:27:31,455 --> 00:27:34,091 HE'S INVOLVED IN THE DEVELOPMENT 671 00:27:34,091 --> 00:27:37,494 OF CLINICAL TRIAL PROTOCOLS, 672 00:27:37,494 --> 00:27:40,798 STATISTICAL ANALYSIS PLANS, AND 673 00:27:40,798 --> 00:27:48,639 NIDCD STATISTICAL GUIDANCE. ANDA 674 00:27:48,639 --> 00:27:50,507 SPECIAL VOLUNTEER CONTRIBUTES A 675 00:27:50,507 --> 00:27:53,010 TREMENDOUS AMOUNT AS A MEDICAL 676 00:27:53,010 --> 00:27:55,279 CENTER, VOLUNTEER, DID WORK FOR 677 00:27:55,279 --> 00:27:57,715 NIDCD AND FOR NICHD OR CHILD 678 00:27:57,715 --> 00:27:58,816 HEALTH AND HUMAN DEVELOPMENT 679 00:27:58,816 --> 00:28:02,419 BEFORE THAT AND IS INVOLVED IN 680 00:28:02,419 --> 00:28:03,854 SPECIAL PROJECTS AND PROVIDES 681 00:28:03,854 --> 00:28:06,056 CONSULTATIONS TO US AND PROVIDES 682 00:28:06,056 --> 00:28:07,124 A LOT OF SUPPORT. 683 00:28:07,124 --> 00:28:12,062 WE HAVE TWO CONTRACTS, ONE IS A 684 00:28:12,062 --> 00:28:12,830 CONTRACT RESEARCH ORGANIZATION 685 00:28:12,830 --> 00:28:14,364 THAT PROVIDES FUNCTION ON THE 686 00:28:14,364 --> 00:28:15,799 LEFT FOR COORDINATION AND 687 00:28:15,799 --> 00:28:18,669 OPERATIONS, AND THE SECOND IS 688 00:28:18,669 --> 00:28:21,939 THE DATA SAFETY MONITORING BOARD 689 00:28:21,939 --> 00:28:25,642 SUPPORT CONTRACT, WHICH HELPS TO 690 00:28:25,642 --> 00:28:27,544 PROVIDE ADMINISTRATIVE SUPPORT 691 00:28:27,544 --> 00:28:32,416 FOR OUR DSMB. 692 00:28:32,416 --> 00:28:34,852 NOT EVERY U01 HAS THEIR OWN, 693 00:28:34,852 --> 00:28:36,587 SOME HAVE THEIR OWN, OVERSEEING 694 00:28:36,587 --> 00:28:38,589 FHIR CLINICAL TRIALS OFFICE. 695 00:28:38,589 --> 00:28:39,857 NEXT SLIDE. 696 00:28:39,857 --> 00:28:42,092 THESE ARE THE ACTIVITIES OF OUR 697 00:28:42,092 --> 00:28:43,293 CLINICAL TRIALS OFFICE. 698 00:28:43,293 --> 00:28:47,731 THEY PROVIDE A TREMENDOUS AMOUNT 699 00:28:47,731 --> 00:28:49,733 OF GUIDANCE, CONSULTATION, 700 00:28:49,733 --> 00:28:50,534 EXTRAMURAL INVESTIGATORS AND 701 00:28:50,534 --> 00:28:55,105 STAFF, IN A VARIETY OF FUNCTIONS 702 00:28:55,105 --> 00:28:55,405 SHOWN HERE. 703 00:28:55,405 --> 00:28:58,709 WE ALSO MANAGE OUR PORTFOLIO, 704 00:28:58,709 --> 00:29:02,646 INCLUDING OPERATIONS AND 705 00:29:02,646 --> 00:29:03,914 CONTRACTS AND PROVIDE EXPERTISE 706 00:29:03,914 --> 00:29:05,649 AND OVERSIGHT FOR HIGH RISK U01 707 00:29:05,649 --> 00:29:07,351 CLINICAL TRIALS, SO THEY ARE A 708 00:29:07,351 --> 00:29:12,956 VERY BUSY GROUP. 709 00:29:12,956 --> 00:29:16,026 AND THE NEXT SLIDE. 710 00:29:16,026 --> 00:29:18,162 HOW CAN CLINICAL TRIALS ADVANCE 711 00:29:18,162 --> 00:29:19,630 SAFE AND BENEFICIAL RESEARCH AND 712 00:29:19,630 --> 00:29:20,998 INTERVENTIONS INTO PRACTICE? 713 00:29:20,998 --> 00:29:22,132 THAT'S WHAT WE WANT TO KNOW, 714 00:29:22,132 --> 00:29:24,268 WHAT ARE WE DOING WELL, WHAT CAN 715 00:29:24,268 --> 00:29:28,605 WE DO BETTER, WHAT ARE THE NEEDS 716 00:29:28,605 --> 00:29:32,743 OF OUR RESEARCH COMMUNITY WE CAN 717 00:29:32,743 --> 00:29:34,311 FULFILL. 718 00:29:34,311 --> 00:29:37,981 AND SO I WILL LEAVE THAT AT 719 00:29:37,981 --> 00:29:39,449 THAT, AND WE'RE VERY MUCH 720 00:29:39,449 --> 00:29:40,417 LOOKING FORWARD TO AND 721 00:29:40,417 --> 00:29:42,486 APPRECIATE THE WORK OF THIS 722 00:29:42,486 --> 00:29:43,353 WORKING GROUP. 723 00:29:43,353 --> 00:29:45,722 I'LL ASK NOW IF ANY MEMBERS OF 724 00:29:45,722 --> 00:29:47,858 OUR COUNCIL HAVE AN INTEREST IN 725 00:29:47,858 --> 00:29:50,627 WORKING ON THIS, PLEASE DO LET 726 00:29:50,627 --> 00:29:53,030 ME KNOW, I WOULD VERY MUCH 727 00:29:53,030 --> 00:29:55,666 WELCOME YOUR INPUT AND YOUR 728 00:29:55,666 --> 00:29:55,999 PARTICIPATION. 729 00:29:55,999 --> 00:29:59,036 AND THE LAST SLIDE SHOWS OUR 730 00:29:59,036 --> 00:29:59,369 AGENDA. 731 00:29:59,369 --> 00:30:02,339 SHORTLY I WILL TURN THIS OVER TO 732 00:30:02,339 --> 00:30:04,641 MR. ERIC WILLIAMS, WHO WAS OUR 733 00:30:04,641 --> 00:30:06,810 BUDGET OFFICER FOR THE BUDGET 734 00:30:06,810 --> 00:30:07,344 REPORT. 735 00:30:07,344 --> 00:30:10,547 WE WILL THEN HEAR FROM DR. BECKY 736 00:30:10,547 --> 00:30:12,216 MILLER, REPORT OF THE DIVISION 737 00:30:12,216 --> 00:30:13,884 OF EXTRAMURAL ACTIVITIES. 738 00:30:13,884 --> 00:30:19,857 WE HAVE TWO NEW COUNCIL MEMBER 739 00:30:19,857 --> 00:30:20,824 PRESENTATIONS, FROM DOCTORS 740 00:30:20,824 --> 00:30:22,926 NANCY YOUNG AND SWATHI KIRAN AND 741 00:30:22,926 --> 00:30:25,562 REMARKS FROM A REAR TIRING 742 00:30:25,562 --> 00:30:26,263 MEMBER. 743 00:30:26,263 --> 00:30:34,304 NEXT SLIDE. 744 00:30:34,304 --> 00:30:34,872 ERIC, WELCOME. 745 00:30:34,872 --> 00:30:39,877 >> I'M GOING TO WAIT UNTIL I CAN 746 00:30:39,877 --> 00:30:42,713 SEE IT POP UP. 747 00:30:42,713 --> 00:30:53,023 >> ONE SECOND. 748 00:31:05,836 --> 00:31:07,571 >> CAN YOU SEE THE SCREEN IN. 749 00:31:07,571 --> 00:31:10,908 >> I CAN, THANK YOU. 750 00:31:10,908 --> 00:31:12,709 >> I DID MAKE UPDATES. 751 00:31:12,709 --> 00:31:16,813 WE'RE GETTING CONSTANT UPDATES 752 00:31:16,813 --> 00:31:17,981 FROM TH ADMINISTRATION, FROM 753 00:31:17,981 --> 00:31:24,021 INTERNAL NIH ON DIFFERENT 754 00:31:24,021 --> 00:31:26,456 TOPICS, SO WE HAVE TO PRESENT 755 00:31:26,456 --> 00:31:28,725 THE LAST PIECE OF INFORMATION 756 00:31:28,725 --> 00:31:30,627 THAT WAS PRESENTED TO CONGRESS, 757 00:31:30,627 --> 00:31:33,096 AND WITH CONTINUING RESOLUTION 758 00:31:33,096 --> 00:31:34,431 THAT STARTED THIS YEAR, AND 759 00:31:34,431 --> 00:31:35,999 CHANGES IN GUIDANCE AND WHAT 760 00:31:35,999 --> 00:31:42,239 NOT, THERE HASN'T BEEN AN 761 00:31:42,239 --> 00:31:43,840 UPDATED MECHANISM TABLE OR 762 00:31:43,840 --> 00:31:44,841 OPERATING PLAN TRANSMITTED TO 763 00:31:44,841 --> 00:31:45,575 CONGRESS. 764 00:31:45,575 --> 00:31:46,710 I'LL SPEAK TO THIS ONE YEAR. 765 00:31:46,710 --> 00:31:50,147 THIS IS HOW WE ENDED 2024. 766 00:31:50,147 --> 00:31:52,716 I WANT TO TALK TO THE CHANGES 767 00:31:52,716 --> 00:31:59,222 RHEE WE'RE MAKING IN 2025, 768 00:31:59,222 --> 00:32:02,359 WAITING FOR GUIDANCE IN 2026, 769 00:32:02,359 --> 00:32:06,330 AND WE'LL HAVE TO MAKE SOME 770 00:32:06,330 --> 00:32:07,864 CHANGES TO OUR 2025 OUTCOMES. 771 00:32:07,864 --> 00:32:11,768 AS YOU CAN SEE IN 2024, 772 00:32:11,768 --> 00:32:14,071 NON-COMPETING NUMBER WAS LOW TO 773 00:32:14,071 --> 00:32:19,109 WHAT WE NORMALLY HAVE, UP AROUND 774 00:32:19,109 --> 00:32:20,110 271, 272 MILLION. 775 00:32:20,110 --> 00:32:21,044 WE'RE LOOKING TO INCREASE OUR 776 00:32:21,044 --> 00:32:23,513 NUMBERS THIS YEAR TO GET BACK UP 777 00:32:23,513 --> 00:32:24,781 TO THERE. 778 00:32:24,781 --> 00:32:26,984 BASED ON EXECUTIVE ORDERS, 779 00:32:26,984 --> 00:32:29,152 ADMINISTRATIVE SUPPLEMENTS HAVE 780 00:32:29,152 --> 00:32:30,787 BEEN PRETTY MUCH GUTTED. 781 00:32:30,787 --> 00:32:32,889 WE MIGHT SPEND A MILLION DOLLARS 782 00:32:32,889 --> 00:32:36,026 ON THAT, SO THOSE FUNDS WILL GO 783 00:32:36,026 --> 00:32:38,762 DOWN COMPARED TO 2024. 784 00:32:38,762 --> 00:32:39,463 SIMILARLY COMPETING DOLLARS WILL 785 00:32:39,463 --> 00:32:41,031 GO DOWN AS WELL. 786 00:32:41,031 --> 00:32:48,338 WE HAD ANOTHER FLAT BUDGET, AND 787 00:32:48,338 --> 00:32:52,142 HOLES TO FILL, INCLUDING 788 00:32:52,142 --> 00:32:54,044 INCREASES TO NON-COMPETING BASE. 789 00:32:54,044 --> 00:32:55,812 WOULDN'T SAY THERE'S MUCH OF A 790 00:32:55,812 --> 00:32:56,947 CHANGE TO RESEARCH CENTERS, 791 00:32:56,947 --> 00:32:58,715 STAYING PRETTY MUCH FLAT, AS 792 00:32:58,715 --> 00:33:00,350 WELL AS CAREERS. 793 00:33:00,350 --> 00:33:01,585 THE OTHER RESEARCH CATEGORY WE 794 00:33:01,585 --> 00:33:03,453 WERE SEEING A LITTLE BIT OF 795 00:33:03,453 --> 00:33:05,622 INCREASE BUT BASED ON SOME 796 00:33:05,622 --> 00:33:07,457 EXECUTIVE ORDERS WHERE THE 797 00:33:07,457 --> 00:33:09,226 R25s ARE, THE DIVERSITY 798 00:33:09,226 --> 00:33:10,127 R25s, THAT NUMBER PROBABLY AT 799 00:33:10,127 --> 00:33:12,629 THIS POINT IS GOING TO GO DOWN A 800 00:33:12,629 --> 00:33:13,830 LITTLE BIT. 801 00:33:13,830 --> 00:33:15,899 >> I'M GOING TO INTERRUPT. 802 00:33:15,899 --> 00:33:17,868 BROOKE, CAN YOU ZOOM IN OR GO TO 803 00:33:17,868 --> 00:33:21,171 THE PRESENTER VIEW SO WE CAN SEE 804 00:33:21,171 --> 00:33:21,705 IT LARGER? 805 00:33:21,705 --> 00:33:26,243 >> LET ME SEE. 806 00:33:26,243 --> 00:33:32,749 ONE SECOND. 807 00:33:32,749 --> 00:33:35,952 THANK YOU. 808 00:33:35,952 --> 00:33:40,424 >> SO IF WE COULD PAN DOWN ON 809 00:33:40,424 --> 00:33:43,193 THE TABLE. 810 00:33:43,193 --> 00:33:43,827 INSTITUTIONAL TRAINING, A 811 00:33:43,827 --> 00:33:44,628 DECREASE, NO CHANGE TO THE 812 00:33:44,628 --> 00:33:47,431 NUMBER OF PEOPLE WE'LL BE 813 00:33:47,431 --> 00:33:50,434 SERVICING THROUGH INSTITUTIONAL 814 00:33:50,434 --> 00:33:52,402 TRAINING, JUST SOME SCALEDOWNS 815 00:33:52,402 --> 00:33:54,171 WE'LL BE CLEANING UP, WE KEPT A 816 00:33:54,171 --> 00:33:56,673 LARGE BALANCE THERE TO BE USED 817 00:33:56,673 --> 00:33:59,843 TO TAKE CARE OF OTHER PRIORITIES 818 00:33:59,843 --> 00:34:00,811 THIS YEAR. 819 00:34:00,811 --> 00:34:03,914 AND THE R&D CONTRACT SECTION, 820 00:34:03,914 --> 00:34:04,981 ORIGINALLY WE WERE THINKING IT 821 00:34:04,981 --> 00:34:06,616 WAS GOING TO GO DOWN, BASED ON 822 00:34:06,616 --> 00:34:08,585 THE WAY WE SEE SOME OF THE 823 00:34:08,585 --> 00:34:10,487 THINGS HAPPENING NEXT YEAR, 824 00:34:10,487 --> 00:34:11,688 WE'RE ACTUALLY GOING TO SPEND 825 00:34:11,688 --> 00:34:15,859 PROBABLY A LITTLE BIT MORE SO WE 826 00:34:15,859 --> 00:34:19,596 CAN PAY DOWN OUR R&D CONTRACTS 827 00:34:19,596 --> 00:34:25,202 AND PREPAY THEM FOR FY 26 AND FY 828 00:34:25,202 --> 00:34:25,602 27. 829 00:34:25,602 --> 00:34:28,839 INTRAMURAL RESEARCH, BOTH WILL 830 00:34:28,839 --> 00:34:31,074 SEE BUMP UPS BASED ON SOME 831 00:34:31,074 --> 00:34:33,009 SALARY INCREASES, SOME OTHER 832 00:34:33,009 --> 00:34:34,411 FACTORS, BUT AS MUCH AS WE 833 00:34:34,411 --> 00:34:36,480 THOUGHT IT'S GOING TO BE 834 00:34:36,480 --> 00:34:39,649 TEMPERED DOWN BASED ON, YOU 835 00:34:39,649 --> 00:34:42,252 KNOW, SOME OF THE HR ACTIONS 836 00:34:42,252 --> 00:34:44,020 THAT HAPPENED SINCE THE 837 00:34:44,020 --> 00:34:46,022 ADMINISTRATION CAME IN, SO 838 00:34:46,022 --> 00:34:48,492 PROBABLY A LITTLE BIT OF 839 00:34:48,492 --> 00:34:50,727 INCREASE, A CHALLENGE SPENDING 840 00:34:50,727 --> 00:34:53,597 SOME MONEY BECAUSE SOME 841 00:34:53,597 --> 00:34:55,198 CONTRACTING STAFF HAVE BEEN LET 842 00:34:55,198 --> 00:34:59,603 GO AND WE'RE HAVING TROUBLE 843 00:34:59,603 --> 00:35:03,173 GETTING SOME CONTRACTING ACTIONS 844 00:35:03,173 --> 00:35:03,507 TAKING PLACE. 845 00:35:03,507 --> 00:35:05,375 YEAH, I DON'T HAVE MORE I'M 846 00:35:05,375 --> 00:35:07,711 ALLOWED TO GIVE YOU NOW BUT I 847 00:35:07,711 --> 00:35:11,314 THINK WE HAVE ABOUT THREE OR 848 00:35:11,314 --> 00:35:13,483 FOUR SCENARIOS AND I'M HAPPY TO 849 00:35:13,483 --> 00:35:14,651 ADDRESS THOSE IF ANYONE HAS 850 00:35:14,651 --> 00:35:15,285 QUESTIONS. 851 00:35:15,285 --> 00:35:21,825 GOING TO THE NEXT SLIDE PLEASE. 852 00:35:21,825 --> 00:35:23,426 LOOKING AT WHAT WE DID WITH OUR 853 00:35:23,426 --> 00:35:27,097 MONEY AS FAR AS OUR MISSION 854 00:35:27,097 --> 00:35:30,267 AREAS, SO THESE PIECHARTS SHOW 855 00:35:30,267 --> 00:35:32,235 COMPARISON BETWEEN 2023 AND 856 00:35:32,235 --> 00:35:32,636 2024. 857 00:35:32,636 --> 00:35:34,204 THE REAL DIFFERENCE WE DON'T 858 00:35:34,204 --> 00:35:37,040 MOVE SIGNIFICANTLY FROM ONE YEAR 859 00:35:37,040 --> 00:35:39,576 TO THE NEXT YEAR, BUT BETWEEN 23 860 00:35:39,576 --> 00:35:41,077 AND 24 LANGUAGE WENT DOWN A 861 00:35:41,077 --> 00:35:43,380 LITTLE BIT AND SMELL WENT UP, 862 00:35:43,380 --> 00:35:45,882 EVERYTHING ELSE IS PROBABLY 863 00:35:45,882 --> 00:35:47,350 WITHIN A LITTLE MARGIN OF ONE OR 864 00:35:47,350 --> 00:35:52,689 TWO GRAND GOING TO ONE OR THE 865 00:35:52,689 --> 00:35:56,426 OTHER. 866 00:35:56,426 --> 00:35:57,794 NEXT SLIDE PLEASE. 867 00:35:57,794 --> 00:36:02,098 JUST LOOKING AT OUR SUCCESS 868 00:36:02,098 --> 00:36:04,167 RATE, SO NIDCD IS VERY -- HAS A 869 00:36:04,167 --> 00:36:05,302 HIGHER SUCCESS RATE THAN THE 870 00:36:05,302 --> 00:36:11,608 REST OF NIH WHEN IT COMES TO 871 00:36:11,608 --> 00:36:12,475 RESEARCH PROJECT GRANTS 872 00:36:12,475 --> 00:36:14,911 TYPICALLY YEAR OVER YEAR AWARD A 873 00:36:14,911 --> 00:36:16,746 FIVE PERCENTAGE MORE OF OUR 874 00:36:16,746 --> 00:36:17,847 APPLICATIONS THAN THE REST OF 875 00:36:17,847 --> 00:36:21,551 NIH, AND WHEN IT COMES TO OUR 876 00:36:21,551 --> 00:36:26,823 FELLOWSHIPS SUCH AS NEXT TABLE 877 00:36:26,823 --> 00:36:28,258 DOWN, ABOUT 10% BETTER SUCCESS 878 00:36:28,258 --> 00:36:34,164 RATE THAN THE REST OF NIH. 879 00:36:34,164 --> 00:36:37,133 SO NEXT TABLE, SORRY, NEXT 880 00:36:37,133 --> 00:36:38,969 SLIDE, JUST LOOKING AT OUR 881 00:36:38,969 --> 00:36:42,138 BUDGET WE'VE HAD THREE FLAT 882 00:36:42,138 --> 00:36:43,273 BUDGETS BACK TO BACK TO BACK. 883 00:36:43,273 --> 00:36:46,142 THIS IS A HUGE CHALLENGE FOR US 884 00:36:46,142 --> 00:36:47,010 TO UNDERTAKE. 885 00:36:47,010 --> 00:36:50,146 WE DO NOT KNOW REALLY WHAT FY 26 886 00:36:50,146 --> 00:36:53,416 BUDGET IS GOING TO LOOK LIKE. 887 00:36:53,416 --> 00:36:55,518 THE PRESIDENT'S BUDGET, YOU 888 00:36:55,518 --> 00:36:57,621 KNOW, THIS IS SIMILAR TO THE 889 00:36:57,621 --> 00:36:59,089 PRESIDENT'S BUDGET WE RECEIVED 890 00:36:59,089 --> 00:37:00,223 IN THE FIRST TRUMP 891 00:37:00,223 --> 00:37:01,992 ADMINISTRATION, WHERE THERE WERE 892 00:37:01,992 --> 00:37:03,026 CUTS AND OBAMA ADMINISTRATION 893 00:37:03,026 --> 00:37:05,595 WHERE THERE WAS SIGNIFICANT 894 00:37:05,595 --> 00:37:10,634 GROWTH, AND THESE ARE -- TEND TO 895 00:37:10,634 --> 00:37:13,270 BE POSTURING DOCUMENTS. 896 00:37:13,270 --> 00:37:15,805 THIS YEAR REFLECTS 40% CUT, 897 00:37:15,805 --> 00:37:17,674 THERE'S SOME ELEMENTS IN THERE 898 00:37:17,674 --> 00:37:21,344 THAT THEY ASSUME IS GOING TO 899 00:37:21,344 --> 00:37:25,415 NECESSITATE 40% CUT INCLUDING 900 00:37:25,415 --> 00:37:27,517 15% INDIRECT COST CAP, SALARY 901 00:37:27,517 --> 00:37:30,920 CAPS, RESTRUCTURING AND WHAT 902 00:37:30,920 --> 00:37:31,254 NOT. 903 00:37:31,254 --> 00:37:32,222 WE'RE WAITING TO SEE WHAT THE 904 00:37:32,222 --> 00:37:33,957 HOUSE AND SENATE MARKS ARE 905 00:37:33,957 --> 00:37:35,925 BECAUSE OUR FINAL BUDGE SET 906 00:37:35,925 --> 00:37:38,128 TYPICALLY MORE IN ALIGNMENT WITH 907 00:37:38,128 --> 00:37:40,797 WHAT THOSE MARKS ARE, THAN THE 908 00:37:40,797 --> 00:37:44,701 PRESIDENT'S BUDGET. 909 00:37:44,701 --> 00:37:45,902 SO OUR STRATEGY AT THIS POINT 910 00:37:45,902 --> 00:37:49,072 WITH THE BUDGE SET JUST TO BE 911 00:37:49,072 --> 00:37:50,140 PATIENT. 912 00:37:50,140 --> 00:37:52,008 WE NEED MORE DATA POINTS SO WE 913 00:37:52,008 --> 00:37:55,078 KNOW HOW WE'RE GOING TO END UP 914 00:37:55,078 --> 00:37:55,745 THIS YEAR. 915 00:37:55,745 --> 00:37:56,980 HPPs AND END OF YEAR SPENDING 916 00:37:56,980 --> 00:37:58,481 WE HAVE TO BE STRATEGIC ABOUT 917 00:37:58,481 --> 00:38:00,116 HOW WE DO IT TO SET OURSELVES UP 918 00:38:00,116 --> 00:38:01,685 BEST FOR NEXT YEAR. 919 00:38:01,685 --> 00:38:03,753 THERE ARE CUTS, WE'RE GOING TO 920 00:38:03,753 --> 00:38:05,522 HAVE DO THINGS TO PREPARE US FOR 921 00:38:05,522 --> 00:38:11,127 CUTS NEXT YEAR SO WE CAN HAVE A 922 00:38:11,127 --> 00:38:11,961 MORE ROBUST COMPETING PORTFOLIO, 923 00:38:11,961 --> 00:38:13,396 AND SO I THINK IT'S GOING TO BE 924 00:38:13,396 --> 00:38:17,200 A LITTLE BIT OF WAITING GAME ON 925 00:38:17,200 --> 00:38:18,301 THESE NEGOTIATIONS AND CAPITAL 926 00:38:18,301 --> 00:38:21,338 HILL TAKE PLACE SO WE NEED TO BE 927 00:38:21,338 --> 00:38:22,005 FLEXIBLE. 928 00:38:22,005 --> 00:38:25,275 WE WILL GET PAYLINE OUT. 929 00:38:25,275 --> 00:38:26,976 WE'LL GET CERTAIN PAY PLANS OUT, 930 00:38:26,976 --> 00:38:29,446 BUT AS FAR AS LIKE THE BULK OF 931 00:38:29,446 --> 00:38:33,083 MONEY TOWARD THE END OF THE YEAR 932 00:38:33,083 --> 00:38:36,286 RESOLUTION OF SOME OF THESE 933 00:38:36,286 --> 00:38:38,555 COURT ORDERS, WITHHOLDING FUND, 934 00:38:38,555 --> 00:38:39,689 CERTAIN INSTITUTES AND 935 00:38:39,689 --> 00:38:40,623 UNIVERSITIES, WE JUST HAVE TO 936 00:38:40,623 --> 00:38:43,259 SEE THOSE PLAY OUT BEFORE WE CAN 937 00:38:43,259 --> 00:38:44,594 REALLY MAKE A DETERMINATION ON 938 00:38:44,594 --> 00:38:47,397 HOW WE SPEND OUT THE REST OF THE 939 00:38:47,397 --> 00:38:47,864 YEAR. 940 00:38:47,864 --> 00:38:51,234 WITH THAT, I'M OPEN FOR ANY 941 00:38:51,234 --> 00:39:01,711 QUESTIONS ANYONE MIGHT HAVE. 942 00:39:05,348 --> 00:39:06,549 I SEE ONE. 943 00:39:06,549 --> 00:39:08,818 >> I WONDER WILL THIS SLIDE DECK 944 00:39:08,818 --> 00:39:09,519 BE AVAILABLE? 945 00:39:09,519 --> 00:39:13,022 SOME OF THEM WENT BY VERY FAST 946 00:39:13,022 --> 00:39:17,160 OR WEREN'T VISIBLE ON THE 947 00:39:17,160 --> 00:39:17,394 SCREEN. 948 00:39:17,394 --> 00:39:21,531 >> WE CAN POST THAT IN ECB FOR 949 00:39:21,531 --> 00:39:22,232 YOU, YEAH. 950 00:39:22,232 --> 00:39:24,134 >> THANK YOU. 951 00:39:24,134 --> 00:39:28,004 >> ERIC'S CAREFUL TO PRESENT 952 00:39:28,004 --> 00:39:29,139 ONLY PUBLICLY AVAILABLE 953 00:39:29,139 --> 00:39:29,472 INFORMATION. 954 00:39:29,472 --> 00:39:34,511 ANY OTHER QUESTIONS? 955 00:39:34,511 --> 00:39:35,645 ERIC, THANK YOU VERY MUCH. 956 00:39:35,645 --> 00:39:39,048 THANK YOU FOR ALL OF YOUR WORK 957 00:39:39,048 --> 00:39:39,582 ON THIS. 958 00:39:39,582 --> 00:39:43,186 IT'S A VERY HEAVY LIFT TO 959 00:39:43,186 --> 00:39:47,056 BALANCE ALL OF THESE COMPETING 960 00:39:47,056 --> 00:39:48,992 PRIORITIES AND UNCERTAINTIES SO 961 00:39:48,992 --> 00:39:50,059 WE APPRECIATE IT. 962 00:39:50,059 --> 00:39:50,994 >> THANK YOU. 963 00:39:50,994 --> 00:39:52,896 >> ALL RIGHT. 964 00:39:52,896 --> 00:39:54,531 NEXT WE HAVE DR. MILLER WHO IS 965 00:39:54,531 --> 00:40:00,703 GOING TO GIVE THE TRIENNIAL 966 00:40:00,703 --> 00:40:04,073 INCLUSION REPORT. 967 00:40:04,073 --> 00:40:04,340 >> OKAY. 968 00:40:04,340 --> 00:40:05,775 SO, I'LL GIVE THE REPORT AS PART 969 00:40:05,775 --> 00:40:12,182 OF THE REPORT OF THE DIVISION OF 970 00:40:12,182 --> 00:40:14,584 EXTRAMURAL ACTIVITIES. 971 00:40:14,584 --> 00:40:18,455 SO, FIRST, THE INCLUSION POLICY 972 00:40:18,455 --> 00:40:20,023 IS DESIGNED TO GUARANTEE 973 00:40:20,023 --> 00:40:21,090 CLINICAL TRIALS EXAMINE EFFECTS 974 00:40:21,090 --> 00:40:25,562 OF SEX AND RACIAL AND ETHNIC 975 00:40:25,562 --> 00:40:34,737 GROUPS, AND SO TRIENNIAL 976 00:40:34,737 --> 00:40:36,706 INCLUSION REPORT DESCRIBES 977 00:40:36,706 --> 00:40:37,707 COMPLIANCE, AND 21ST CENTURY 978 00:40:37,707 --> 00:40:39,476 CURES ACT TRAININGED THAT TO 979 00:40:39,476 --> 00:40:42,312 TRI'EM REPORTING, OFFICE OF 980 00:40:42,312 --> 00:40:44,180 MANAGEMENT AND BUDGET SETS 981 00:40:44,180 --> 00:40:44,914 MINIMUM STANDARDS FOR 982 00:40:44,914 --> 00:40:45,715 MAINTAINING, COLLECTING, 983 00:40:45,715 --> 00:40:50,487 PRESENTING DATA. 984 00:40:50,487 --> 00:40:52,922 AND THEN POSTED IN ECB PRIOR TO 985 00:40:52,922 --> 00:40:54,390 THE MEETING TO REVIEW. 986 00:40:54,390 --> 00:40:58,261 THE OUTLINE OF WHAT THE REPORT 987 00:40:58,261 --> 00:41:01,231 DID COVER WAS THAT THERE WAS 988 00:41:01,231 --> 00:41:02,899 MISSION STATEMENT, INSTITUTE 989 00:41:02,899 --> 00:41:06,503 PORTFOLIO, BACKGROUND, 990 00:41:06,503 --> 00:41:07,437 STRATEGIES FOR COMPLIANCE AND 991 00:41:07,437 --> 00:41:09,138 ANALYSIS AND INTERPRETATION OF 992 00:41:09,138 --> 00:41:11,441 THE DATA. 993 00:41:11,441 --> 00:41:13,943 THIS INCLUSION TABLE AND REPORTS 994 00:41:13,943 --> 00:41:15,812 WERE PREPARED AND GENERATED BY 995 00:41:15,812 --> 00:41:18,348 NIH OFFICE OF EXTRAMURAL 996 00:41:18,348 --> 00:41:18,615 RESEARCH. 997 00:41:18,615 --> 00:41:20,950 THIS TABLE 2.1 IS TOTAL 998 00:41:20,950 --> 00:41:24,220 INCLUSION REPORT FOR NIH DEFINED 999 00:41:24,220 --> 00:41:26,589 CLINICAL RESEARCH, EACH 1000 00:41:26,589 --> 00:41:27,657 INCLUSION ENROLLMENT REPORT, 1001 00:41:27,657 --> 00:41:29,158 IER, CONTAINS THE INCLUSION DATA 1002 00:41:29,158 --> 00:41:31,261 FOR HUMAN SUBJECT RESEARCH 1003 00:41:31,261 --> 00:41:32,295 COMPONENT OF A PROJECT, 1004 00:41:32,295 --> 00:41:34,531 THEREFORE PROJECTS MAY HAVE 1005 00:41:34,531 --> 00:41:36,199 MULTIPLE IERs. 1006 00:41:36,199 --> 00:41:39,002 AND THE IERs WITHOUT 1007 00:41:39,002 --> 00:41:39,636 ENROLLMENT, INVESTIGATORS 1008 00:41:39,636 --> 00:41:40,970 PLANNED TO RECRUIT HUMAN 1009 00:41:40,970 --> 00:41:44,474 SUBJECTS THAT HAVE NOT ENROLLED. 1010 00:41:44,474 --> 00:41:48,545 THIS TABLE IS THE ENROLLMENT 1011 00:41:48,545 --> 00:41:50,713 DETAILS FOR ALL OF NIH CLINICAL 1012 00:41:50,713 --> 00:41:52,582 TRIALS SUPPORTED BY NIDCD, 1013 00:41:52,582 --> 00:41:55,218 BROKEN BY SEX, RACE, AND 1014 00:41:55,218 --> 00:41:55,485 ETHNICITY. 1015 00:41:55,485 --> 00:41:56,486 I KNOW THERE'S A LOT OF 1016 00:41:56,486 --> 00:41:56,920 INFORMATION. 1017 00:41:56,920 --> 00:41:58,688 I'LL GO THROUGH IT IN MORE 1018 00:41:58,688 --> 00:42:01,524 DETAIL IN THE NEXT SEVERAL 1019 00:42:01,524 --> 00:42:01,758 SLIDES. 1020 00:42:01,758 --> 00:42:03,893 THIS IS THE SEX OF THE 1021 00:42:03,893 --> 00:42:06,462 PARTICIPANTS IN ALL OF OUR 1022 00:42:06,462 --> 00:42:07,931 NIDCD-SUPPORTED CLINICAL 1023 00:42:07,931 --> 00:42:08,197 RESEARCH. 1024 00:42:08,197 --> 00:42:10,600 THE DATA ARE BASED ON 1025 00:42:10,600 --> 00:42:11,734 SELF-REPORTING BY THE HUMAN 1026 00:42:11,734 --> 00:42:13,570 SUBJECTS, SOME CHOOSE NOT TO 1027 00:42:13,570 --> 00:42:15,138 DISCLOSE RACE, ETHNICITY, OR 1028 00:42:15,138 --> 00:42:15,405 SEX. 1029 00:42:15,405 --> 00:42:18,508 THIS RESULTS IN UNKNOWN OR NOT 1030 00:42:18,508 --> 00:42:18,841 REPORTED DATA. 1031 00:42:18,841 --> 00:42:22,345 HERE YOU CAN SEE ROUGHLY EQUAL 1032 00:42:22,345 --> 00:42:25,348 NUMBERS OF PERCENTAGES OF MALE 1033 00:42:25,348 --> 00:42:27,383 AND FEMALE PARTICIPANTS ENROLLED 1034 00:42:27,383 --> 00:42:31,955 IN CLINICAL RESEARCH. 1035 00:42:31,955 --> 00:42:33,823 THIS CHART SHOWS THE RACIAL 1036 00:42:33,823 --> 00:42:36,559 MAKEUP OF PARTICIPANTS IN ALL OF 1037 00:42:36,559 --> 00:42:37,427 OUR SUPPORTED RESEARCH, STEADY 1038 00:42:37,427 --> 00:42:43,466 OVER THE LAST THREE YEARS. 1039 00:42:43,466 --> 00:42:44,834 AND THEN ETHNICITY DEMONSTRATES 1040 00:42:44,834 --> 00:42:48,871 MAJORITY OF PARTICIPANTS ARE 1041 00:42:48,871 --> 00:42:51,274 IDENTIFIED AS NOT HISPANIC. 1042 00:42:51,274 --> 00:42:55,311 AND THEN THE NEXT AND FINAL 1043 00:42:55,311 --> 00:42:56,579 TABLE FROM THE REPORT THAT WE 1044 00:42:56,579 --> 00:43:00,216 PROVIDE IS THE HUMAN SUBJECTS 1045 00:43:00,216 --> 00:43:01,317 ENROLLMENT AND STAGE 3 CLINICAL 1046 00:43:01,317 --> 00:43:04,954 TRIALS, WE DID NOT HAVE ANY 1047 00:43:04,954 --> 00:43:06,889 STAGE 3 CLINICAL TRIALS, SO NO 1048 00:43:06,889 --> 00:43:10,293 DATA TO REPORT. 1049 00:43:10,293 --> 00:43:12,562 AND SUMMARY, JUST AS DEB ALLUDED 1050 00:43:12,562 --> 00:43:13,696 TO, FEWER CLINICAL TRIALS GOING 1051 00:43:13,696 --> 00:43:15,765 ON THAN WE USED TO. 1052 00:43:15,765 --> 00:43:18,034 AND SO OUR NUMBERS ARE 1053 00:43:18,034 --> 00:43:18,968 DEFINITELY DOWN FROM 2022 1054 00:43:18,968 --> 00:43:20,703 REPORT, THE LAST TIME WE 1055 00:43:20,703 --> 00:43:21,904 REPORTED ON THIS. 1056 00:43:21,904 --> 00:43:25,608 STAFF ARE DILIGENT IN MONITORING 1057 00:43:25,608 --> 00:43:26,909 ENROLLMENT PROJECTIONS AND THE 1058 00:43:26,909 --> 00:43:28,945 ACCRUAL PATTERNS OVER THE LIFE 1059 00:43:28,945 --> 00:43:31,214 OF THE GRANTS. 1060 00:43:31,214 --> 00:43:35,418 AND WHEN NECESSARY WE CONTACT 1061 00:43:35,418 --> 00:43:36,586 THE INVESTIGATORS TO CLARIFY OR 1062 00:43:36,586 --> 00:43:40,089 CORRECT ACCRUAL DATA. 1063 00:43:40,089 --> 00:43:41,190 THIS INCLUSION ENROLLMENT DATA 1064 00:43:41,190 --> 00:43:45,895 IS DONE BY THE RCDC, CATEGORIES 1065 00:43:45,895 --> 00:43:49,499 WILL BE AVAILABLE ON THE WEBSIE 1066 00:43:49,499 --> 00:43:50,700 AT A LATER DATE. 1067 00:43:50,700 --> 00:43:52,235 THAT'S IT FOR INCLUSION REPORT. 1068 00:43:52,235 --> 00:43:56,005 AND THEN I WANTED TO SHIFT AND 1069 00:43:56,005 --> 00:43:59,275 WE HAD ONE NO STAFF MEMBER JOIN 1070 00:43:59,275 --> 00:44:02,845 SINCE SEPTEMBER. 1071 00:44:02,845 --> 00:44:04,113 THAT'S MISS NATALIE LANIER, THE 1072 00:44:04,113 --> 00:44:06,315 GRANTS MANAGEMENT SPECIALIST, IN 1073 00:44:06,315 --> 00:44:08,251 OUR GRANTS MANAGEMENT BRANCH. 1074 00:44:08,251 --> 00:44:13,456 BRINGS A DECADE OF EXPERIENCE IN 1075 00:44:13,456 --> 00:44:15,191 GRANTS MANAGEMENT BEFORE COMING 1076 00:44:15,191 --> 00:44:16,592 WORKED THEY NATIONAL HUMAN 1077 00:44:16,592 --> 00:44:18,795 GENOME RESEARCH INSTITUTE AT 1078 00:44:18,795 --> 00:44:19,128 NIH. 1079 00:44:19,128 --> 00:44:22,031 AND HAS SEARCHED AS A SPONSORED 1080 00:44:22,031 --> 00:44:22,765 PROJECT ADMINISTRATOR AT GEORGE 1081 00:44:22,765 --> 00:44:23,533 WASHINGTON UNIVERSITY BEFORE 1082 00:44:23,533 --> 00:44:23,900 THAT. 1083 00:44:23,900 --> 00:44:28,671 SO WE'RE VERY TO HAVE HER ON 1084 00:44:28,671 --> 00:44:29,005 BOARD. 1085 00:44:29,005 --> 00:44:30,106 WE HAVE RETIREMENTS, GREAT 1086 00:44:30,106 --> 00:44:33,743 TIMING SHE CAME ON RIGHT BEFORE 1087 00:44:33,743 --> 00:44:35,278 FOLKS RETIRED. 1088 00:44:35,278 --> 00:44:38,881 AND THEN I COULDN'T END WITHOUT 1089 00:44:38,881 --> 00:44:39,882 RECOGNIZING THE AMAZING PEER 1090 00:44:39,882 --> 00:44:41,284 REVIEWED STAFF AT NIDCD. 1091 00:44:41,284 --> 00:44:44,454 SO AS MANY OF YOU HEARD PEER 1092 00:44:44,454 --> 00:44:46,389 REVIEW AT NIH IS BEING 1093 00:44:46,389 --> 00:44:48,424 CONSOLIDATED IN THE CENTER FOR 1094 00:44:48,424 --> 00:44:49,292 SCIENTIFIC REVIEW, ALL PEER 1095 00:44:49,292 --> 00:44:55,131 REVIEW WILL BE MANAGED, IN 1096 00:44:55,131 --> 00:44:56,299 MEETINGS MANAGED BY CSR. 1097 00:44:56,299 --> 00:44:59,402 OUR STAFF WILL MOVE TO CSR BY 1098 00:44:59,402 --> 00:45:04,006 THE END OF MAY, WHILE THE REVIEW 1099 00:45:04,006 --> 00:45:05,007 STAFF ARE TRANSITIONING, THEY 1100 00:45:05,007 --> 00:45:07,877 ARE STILL WITH US ON SHORT 1101 00:45:07,877 --> 00:45:10,146 DETAIL TO CSR, ALREADY HELPING 1102 00:45:10,146 --> 00:45:11,914 OUT WITH PEER REVIEW, AN MANY 1103 00:45:11,914 --> 00:45:13,282 MEETINGS WE HAD RUN OURSELVES 1104 00:45:13,282 --> 00:45:15,118 WILL CONTINUE TO BE RUN BY SOME 1105 00:45:15,118 --> 00:45:17,820 OF OUR STAFF FOR THE NEXT ROUND 1106 00:45:17,820 --> 00:45:19,889 AT LEAST AND THEN I THINK SOME 1107 00:45:19,889 --> 00:45:24,794 WILL CONTINUE TO BE WITHIN STUDY 1108 00:45:24,794 --> 00:45:25,828 SECTIONS THAT OUR SCIENTIFIC 1109 00:45:25,828 --> 00:45:29,165 REVIEW STAFF AS PART OF CSR WILL 1110 00:45:29,165 --> 00:45:30,500 BE FOCUSED IN OUR SCIENTIFIC 1111 00:45:30,500 --> 00:45:30,833 AREAS. 1112 00:45:30,833 --> 00:45:32,835 WHILE THE STAFF WILL BE SERVING 1113 00:45:32,835 --> 00:45:35,538 RESEARCH COMMUNITY WE WILL 1114 00:45:35,538 --> 00:45:37,340 CERTAINLY MISS THEM GREATLY, 1115 00:45:37,340 --> 00:45:39,142 WE'RE ALL VERY CLOSE AND THEIR 1116 00:45:39,142 --> 00:45:41,677 ABSENCE WILL LEAVE A HOLE IN OUR 1117 00:45:41,677 --> 00:45:41,944 INSTITUTE. 1118 00:45:41,944 --> 00:45:43,813 SO WE LOOK FORWARD TO CONTINUING 1119 00:45:43,813 --> 00:45:45,381 TO WORK WITH THEM AS A PARTNER 1120 00:45:45,381 --> 00:45:47,316 TO HELP US FUND THE BEST 1121 00:45:47,316 --> 00:45:47,550 SCIENCE. 1122 00:45:47,550 --> 00:45:52,321 PLEASE JOIN ME IN THANKING 1123 00:45:52,321 --> 00:45:54,257 TANIA, ANDRE A, SONIA, BOBBY AND 1124 00:45:54,257 --> 00:45:57,426 KATHY AND WISH THEM WELL AS THEY 1125 00:45:57,426 --> 00:45:58,227 MOVE TO CSR. 1126 00:45:58,227 --> 00:46:02,031 IT'S BEEN A BIG YEAR OF STAFFING 1127 00:46:02,031 --> 00:46:03,266 CHANGES, WITH SEVERAL 1128 00:46:03,266 --> 00:46:04,534 RETIREMENTS THAT REDUCED OUR 1129 00:46:04,534 --> 00:46:06,536 NUMBERS, BUT EVERYONE HAS BEEN 1130 00:46:06,536 --> 00:46:07,303 HELPING STEP UP WHEN THEY CAN 1131 00:46:07,303 --> 00:46:10,940 AND WHERE THEY CAN SO I THANK 1132 00:46:10,940 --> 00:46:12,175 EVERYONE FOR THEIR WORK TO HELP 1133 00:46:12,175 --> 00:46:16,179 US FUND THE BEST SCIENCE AND 1134 00:46:16,179 --> 00:46:19,816 ENSURING COMPLIANCE. 1135 00:46:19,816 --> 00:46:21,884 THAT'S MY REPORT FOR DEA. 1136 00:46:21,884 --> 00:46:24,187 >> THANK YOU, BECKY. 1137 00:46:24,187 --> 00:46:25,922 WE'LL MOVE NOW TO A PART OF THE 1138 00:46:25,922 --> 00:46:27,890 PROGRAM THAT I'M VERY EXCITED 1139 00:46:27,890 --> 00:46:31,427 ABOUT, AS I MENTIONED WE HAVE 1140 00:46:31,427 --> 00:46:34,363 TWO NEW COUNCIL MEMBER 1141 00:46:34,363 --> 00:46:35,998 PRESENTATIONS, AND I WILL 1142 00:46:35,998 --> 00:46:41,037 WELCOME FIRST DR. NANCY YOUNG. 1143 00:46:41,037 --> 00:46:45,208 >> THANK YOU. 1144 00:46:45,208 --> 00:46:55,718 I'M GOING TO SHARE MY SLIDES. 1145 00:46:56,919 --> 00:47:02,291 >> OKAY. 1146 00:47:02,291 --> 00:47:03,926 THERE WE GO. 1147 00:47:03,926 --> 00:47:05,728 ALL RIGHT. 1148 00:47:05,728 --> 00:47:10,066 SO, I'M A SURGEON, FELLOWSHIP 1149 00:47:10,066 --> 00:47:12,034 TRAINED IN NEUROONTOLOGY, LURIE 1150 00:47:12,034 --> 00:47:17,073 CHILDREN'S HOSPITAL OF CHICAGO, 1151 00:47:17,073 --> 00:47:18,074 FOUND THE COCHLEAR IMPLANT 1152 00:47:18,074 --> 00:47:19,308 PROGRAM, ONE OF THE LARGEST FOR 1153 00:47:19,308 --> 00:47:21,344 CHILDREN IN THE U.S. 1154 00:47:21,344 --> 00:47:23,546 I'VE HAD THE OPPORTUNITY TO 1155 00:47:23,546 --> 00:47:25,514 OBSERVE FIRST HAND MANY CHILDREN 1156 00:47:25,514 --> 00:47:27,917 WHOSE LANGUAGE AND LITERACY HAVE 1157 00:47:27,917 --> 00:47:30,887 BEEN TRANSFORMED BY COCHLEAR 1158 00:47:30,887 --> 00:47:31,520 IMPLANTATION. 1159 00:47:31,520 --> 00:47:33,656 DECADES OF RESEARCH HAVE 1160 00:47:33,656 --> 00:47:34,590 DEMONSTRATED CHILDREN WITH 1161 00:47:34,590 --> 00:47:36,759 CONGENITAL HEARING LOSS FOR WHOM 1162 00:47:36,759 --> 00:47:38,394 HEARING AIDS DO NOT PROVIDE 1163 00:47:38,394 --> 00:47:40,730 ADEQUATE ACCESS TO SPOKEN 1164 00:47:40,730 --> 00:47:43,766 LANGUAGE HAVE BETTER OUTCOMES 1165 00:47:43,766 --> 00:47:45,868 WHEN IMPLANTED EARLY. 1166 00:47:45,868 --> 00:47:47,303 HOWEVER, THERE IS SIGNIFICANT 1167 00:47:47,303 --> 00:47:49,338 VARIABILITY IN LANGUAGE EVEN FOR 1168 00:47:49,338 --> 00:47:52,742 CHILDREN IMPLANTED AT YOUNG AGE. 1169 00:47:52,742 --> 00:47:53,943 THIS GRAPH COMPARES HEARING 1170 00:47:53,943 --> 00:47:56,479 CHILDREN, GRAY BARS, TO YOUNG 1171 00:47:56,479 --> 00:47:58,881 IMPLANTED CHILDREN, YELLOW BARS. 1172 00:47:58,881 --> 00:48:00,750 VARIABILITY IS STRIKING. 1173 00:48:00,750 --> 00:48:03,619 FOR THIS REASON AT PRESENT WE'RE 1174 00:48:03,619 --> 00:48:07,023 UNABLE TO ACCURATELY PREDICT 1175 00:48:07,023 --> 00:48:08,357 LANGUAGE AFTER COCHLEAR 1176 00:48:08,357 --> 00:48:10,326 IMPLANTATION ON THE INDIVIDUAL 1177 00:48:10,326 --> 00:48:12,161 CHILD LEVEL USING TRADITIONAL 1178 00:48:12,161 --> 00:48:16,365 FACTORS OF AGE AT IMPLANTATION 1179 00:48:16,365 --> 00:48:19,402 AND RESIDUAL HEARING. 1180 00:48:19,402 --> 00:48:20,303 VARIABILITY IN OTHER WORDS 1181 00:48:20,303 --> 00:48:22,271 UNPREDICTABLE OUTCOMES IS WHY I 1182 00:48:22,271 --> 00:48:23,706 BECAME INTERESTED IN THE ROLE OF 1183 00:48:23,706 --> 00:48:26,242 THE BRAIN IN LANGUAGE 1184 00:48:26,242 --> 00:48:26,876 DEVELOPMENT. 1185 00:48:26,876 --> 00:48:27,543 WILL UNDERSTANDING 1186 00:48:27,543 --> 00:48:28,311 NEUROPLASTICITY IN CHILDREN WITH 1187 00:48:28,311 --> 00:48:31,514 HEARING LOSS HELP US UNDERSTAND 1188 00:48:31,514 --> 00:48:34,717 VARIABILITY AND IMPROVE 1189 00:48:34,717 --> 00:48:35,351 LANGUAGE? 1190 00:48:35,351 --> 00:48:36,585 SPEECH PERCEPTION INVOLVES 1191 00:48:36,585 --> 00:48:39,522 BOTTOM UP AND TOP DOWN 1192 00:48:39,522 --> 00:48:41,390 PROCESSING, CONSTRUCTION OF 1193 00:48:41,390 --> 00:48:44,026 PERCEPTIONS, FROM SENSORY 1194 00:48:44,026 --> 00:48:45,594 INTEGRATION, AND BENEFITS FROM 1195 00:48:45,594 --> 00:48:47,129 SENSORY INFORMATION AND BENEFITS 1196 00:48:47,129 --> 00:48:50,967 FROM IMPROVEMENT IN THE ACOUSTIC 1197 00:48:50,967 --> 00:48:51,334 SIGNAL. 1198 00:48:51,334 --> 00:48:54,670 TOP-DOWN PROCESSING USES PRIOR 1199 00:48:54,670 --> 00:48:56,105 KNOWLEDGE AND EXPERIENCE TO 1200 00:48:56,105 --> 00:48:57,006 INTERPRET INCOMING INFORMATION, 1201 00:48:57,006 --> 00:48:59,075 OVER TIME THE BRAIN CAN MAKE 1202 00:48:59,075 --> 00:49:04,113 SENSE OF ACOUSTIC SIGNALS FROM 1203 00:49:04,113 --> 00:49:06,015 IMPLANT AND UNDERSTAND SPOKEN 1204 00:49:06,015 --> 00:49:09,785 LANGUAGE. 1205 00:49:09,785 --> 00:49:12,188 OUR RESEARCH GROUP FOCUSES ON 1206 00:49:12,188 --> 00:49:16,125 USING BRAIN ANATOMY IN 3D, HIGH 1207 00:49:16,125 --> 00:49:18,127 RESOLUTION MRI TO PREDICT 1208 00:49:18,127 --> 00:49:21,397 LANGUAGE AFTER IMPLANTATION. 1209 00:49:21,397 --> 00:49:22,865 THE VOLUME, TISSUE DENSITY AND 1210 00:49:22,865 --> 00:49:27,536 SURFACE AREA CAN BE PLEASURED. 1211 00:49:27,536 --> 00:49:28,070 >> NANCY -- 1212 00:49:28,070 --> 00:49:28,637 >> THANK YOU. 1213 00:49:28,637 --> 00:49:30,506 I DIDN'T WANT TO SHUT DOWN ON 1214 00:49:30,506 --> 00:49:30,773 YOU. 1215 00:49:30,773 --> 00:49:31,807 IT'S ALL GOOD. 1216 00:49:31,807 --> 00:49:35,344 I APPRECIATE YOUR HELP. 1217 00:49:35,344 --> 00:49:40,850 SO THE FIRST STEP IS COMPARISON 1218 00:49:40,850 --> 00:49:44,186 OF BRAINS WITH NORMAL HEARING 1219 00:49:44,186 --> 00:49:46,722 AND COCHLEAR IMPLANT CANDIDATES 1220 00:49:46,722 --> 00:49:48,157 TO DETERMINE REGIONS AFFECTED OR 1221 00:49:48,157 --> 00:49:49,992 UNAFFECTED BY HEARING LOSS. 1222 00:49:49,992 --> 00:49:52,328 SECOND TO DETERMINE WHETHER 1223 00:49:52,328 --> 00:49:54,130 AFFECTED OR UNAFFECTED REGIONS 1224 00:49:54,130 --> 00:49:56,432 BEST PREDICT OUTCOMES BY 1225 00:49:56,432 --> 00:49:58,034 BUILDING MACHINE LEARNING 1226 00:49:58,034 --> 00:49:59,235 ENABLED PREDICTION MODELS. 1227 00:49:59,235 --> 00:50:02,071 INITIAL PILOT STUDY REVEALED THE 1228 00:50:02,071 --> 00:50:02,638 UNAFFECTED REGIONS BEST 1229 00:50:02,638 --> 00:50:04,740 PREDICTED WHICH CHILDREN WOULD 1230 00:50:04,740 --> 00:50:06,342 BE HIGH, VERSUS LOW, LANGUAGE 1231 00:50:06,342 --> 00:50:08,844 IMPROVERS IN THE SHORT TERM. 1232 00:50:08,844 --> 00:50:11,847 THE ACCURACY OF MACHINE LEARNING 1233 00:50:11,847 --> 00:50:13,783 MODEL PREDICTIONS USING BRAIN 1234 00:50:13,783 --> 00:50:14,350 STRUCTURE WAS SIGNIFICANTLY 1235 00:50:14,350 --> 00:50:16,318 BETTER THAN MACHINE LEARNING 1236 00:50:16,318 --> 00:50:18,621 PREDICTION USING AGE AT IMPLANT 1237 00:50:18,621 --> 00:50:20,823 AND RESIDUAL HEARING. 1238 00:50:20,823 --> 00:50:22,291 WE HAVE AN NIH-FUNDED 1239 00:50:22,291 --> 00:50:24,860 MULTI-CENTER STUDY TO BUILD 1240 00:50:24,860 --> 00:50:26,395 MACHINE LEARNING MODELS TO 1241 00:50:26,395 --> 00:50:29,532 EVALUATE LONG-TERM OUTCOMES IN 1242 00:50:29,532 --> 00:50:31,033 ENGLISH AND SPANISH LEARNING 1243 00:50:31,033 --> 00:50:33,936 CHILDREN AND TREATMENT ARM 1244 00:50:33,936 --> 00:50:34,937 EXAMINING IF EFFECTIVE 1245 00:50:34,937 --> 00:50:36,472 BEHAVIORAL INTERVENTION CAN 1246 00:50:36,472 --> 00:50:37,673 IMPROVE OUTCOMES OF CHILDREN 1247 00:50:37,673 --> 00:50:44,980 PREDICTED TO BE LOW LANGUAGE 1248 00:50:44,980 --> 00:50:45,347 IMPROVERS. 1249 00:50:45,347 --> 00:50:47,516 RECENTLY, WE EXAMINED IMPACT OF 1250 00:50:47,516 --> 00:50:49,819 DURATION OF HEARING AID USE 1251 00:50:49,819 --> 00:50:51,787 PRIOR TO IMPLANTATION AND FOUND 1252 00:50:51,787 --> 00:50:54,590 EARLY HEARING AID FITTING 1253 00:50:54,590 --> 00:50:55,724 PRESERVES STRUCTURE OF AUDITORY 1254 00:50:55,724 --> 00:50:58,127 CORTEX, BUT THE EFFECT IS 1255 00:50:58,127 --> 00:50:59,829 TEMPORARY AND IS GREATER FOR 1256 00:50:59,829 --> 00:51:05,000 THOSE WITH MORE PROFOUND LOSS. 1257 00:51:05,000 --> 00:51:06,335 STRUCTURAL PRESERVATION MAY 1258 00:51:06,335 --> 00:51:07,870 EXPLAIN PRIOR RESEARCH THAT 1259 00:51:07,870 --> 00:51:10,840 FOUND THAT EARLIER FITTING OF 1260 00:51:10,840 --> 00:51:13,042 HEARING AIDS BEFORE IMPLANTATION 1261 00:51:13,042 --> 00:51:16,645 RESULTED IN BETTER SPEECH 1262 00:51:16,645 --> 00:51:17,847 PERCEPTION. 1263 00:51:17,847 --> 00:51:18,714 NEURAL PRESERVATION HIGHLIGHTS 1264 00:51:18,714 --> 00:51:20,249 CLINICAL IMPORTANCE OF BOTH 1265 00:51:20,249 --> 00:51:25,054 EARLY FITTING OF HEARING AIDS 1266 00:51:25,054 --> 00:51:26,922 AND EARLY IMPLANTATION. 1267 00:51:26,922 --> 00:51:27,723 ACCURATE BRAIN BASED PREDICTION 1268 00:51:27,723 --> 00:51:30,259 MAY THE FIRST STEP TOWARD A NEW 1269 00:51:30,259 --> 00:51:32,094 STANDARD OF CUSTOMIZED CARE, 1270 00:51:32,094 --> 00:51:34,864 PREDICTION HAS THE POTENTIAL TO 1271 00:51:34,864 --> 00:51:39,001 IMPROVE COUNSELING, PROVIDE A 1272 00:51:39,001 --> 00:51:40,236 FRAMEWORK TO DEVELOP THERAPIES 1273 00:51:40,236 --> 00:51:42,304 SPECIFIC TO BRAIN TYPE AND 1274 00:51:42,304 --> 00:51:44,473 REDUCE COST BY DETERMINING 1275 00:51:44,473 --> 00:51:46,709 EFFECTING DOSE AND TYPE OF 1276 00:51:46,709 --> 00:51:47,877 BEHAVIORAL THERAPY. 1277 00:51:47,877 --> 00:51:56,752 NEURAL PREDICTION HAS POTENTIAL 1278 00:51:56,752 --> 00:51:58,187 TO IMPROVE UNDERSTANDING OF 1279 00:51:58,187 --> 00:52:01,023 NEURAL MECHANISMS UNDERLYING 1280 00:52:01,023 --> 00:52:01,924 SPOKEN LANGUAGE DEVELOPMENT. 1281 00:52:01,924 --> 00:52:02,291 >> THANK YOU. 1282 00:52:02,291 --> 00:52:02,992 THAT WAS GREAT. 1283 00:52:02,992 --> 00:52:10,833 ANY QUESTIONS BY MEMBERS OF 1284 00:52:10,833 --> 00:52:12,067 COUNCIL? 1285 00:52:12,067 --> 00:52:13,269 REALLY INTERESTING AND 1286 00:52:13,269 --> 00:52:14,470 COMPELLING WORK. 1287 00:52:14,470 --> 00:52:16,205 THANK YOU SO MUCH. 1288 00:52:16,205 --> 00:52:18,207 >> THANK YOU. 1289 00:52:18,207 --> 00:52:18,807 >> ALL RIGHT. 1290 00:52:18,807 --> 00:52:21,477 SO, NEXT WE'LL HAVE A 1291 00:52:21,477 --> 00:52:24,780 PRESENTATION BY DR. SWATHI 1292 00:52:24,780 --> 00:52:26,982 KIRAN. 1293 00:52:26,982 --> 00:52:35,824 >> I'M TRYING TO SEE IF I CAN 1294 00:52:35,824 --> 00:52:41,697 SHARE MY SCREEN.. 1295 00:52:41,697 --> 00:52:45,334 YOU CAN SEE MY SCREEN NOW? 1296 00:52:45,334 --> 00:52:46,135 >> YES, NOW. 1297 00:52:46,135 --> 00:52:46,735 >> OKAY. 1298 00:52:46,735 --> 00:52:47,636 SO GOOD AFTERNOON. 1299 00:52:47,636 --> 00:52:49,004 I'M REALLY PLEASED TO HAVE THE 1300 00:52:49,004 --> 00:52:51,373 CHANCE TO SHARE THE WORK THAT 1301 00:52:51,373 --> 00:52:52,608 WE'RE DOING AT BOSTON 1302 00:52:52,608 --> 00:52:53,042 UNIVERSITY. 1303 00:52:53,042 --> 00:52:55,311 I HAVE BEEN FORTUNATE TO HAVE 1304 00:52:55,311 --> 00:52:57,346 BEEN FUNDED BY NIH THROUGH MY 1305 00:52:57,346 --> 00:52:59,014 CAREER AND ALSO WANT TO POINT 1306 00:52:59,014 --> 00:53:02,117 OUT I AM THE CO-FOUNDER OF THE 1307 00:53:02,117 --> 00:53:03,085 DIGITAL HEALTH COMPANY, CONSTANT 1308 00:53:03,085 --> 00:53:05,254 THERAPY, THAT I'LL BE TALKING 1309 00:53:05,254 --> 00:53:05,821 ABOUT TODAY. 1310 00:53:05,821 --> 00:53:08,857 WHAT KIND OF CENTER IS FOCUSED 1311 00:53:08,857 --> 00:53:13,362 ON REHABILITATION, RECOVERY, FOR 1312 00:53:13,362 --> 00:53:14,530 NEUROLOGICAL DISESPECIALLY 1313 00:53:14,530 --> 00:53:15,264 SPOKE, ON PRECISION 1314 00:53:15,264 --> 00:53:16,765 REHABILITATION, OUR WORK AND 1315 00:53:16,765 --> 00:53:18,934 VISION OF THE FUTURE WHERE BRAIN 1316 00:53:18,934 --> 00:53:20,736 INJURY SURVIVAL WILL GO TO LAB 1317 00:53:20,736 --> 00:53:23,138 OR CLINIC AND GET A COMPLETE 1318 00:53:23,138 --> 00:53:25,207 NEURAL LANGUAGE AND SOCIAL 1319 00:53:25,207 --> 00:53:26,108 FUNCTIONAL PROFILE WORKUP DONE 1320 00:53:26,108 --> 00:53:28,377 AND THIS INFORMATION WILL BE 1321 00:53:28,377 --> 00:53:31,213 USED TO PREDICT INDIVIDUALIZED 1322 00:53:31,213 --> 00:53:33,282 RECOVERY PROFILES AND THEN BASED 1323 00:53:33,282 --> 00:53:34,883 ON THAT INFORMATION WE CAN 1324 00:53:34,883 --> 00:53:36,585 PROVIDE RECOMMENDATIONS ON 1325 00:53:36,585 --> 00:53:38,220 WHETHER THAT PERSON SHOULD 1326 00:53:38,220 --> 00:53:39,355 RECEIVE INTENSIVE INDIVIDUAL 1327 00:53:39,355 --> 00:53:42,625 THERAPY, OR GO TO A SOCIAL GROUP 1328 00:53:42,625 --> 00:53:45,461 THERAPY, OR RECEIVE VOCATIONAL 1329 00:53:45,461 --> 00:53:45,894 TRAINING. 1330 00:53:45,894 --> 00:53:47,663 WE'RE NOT THERE YET. 1331 00:53:47,663 --> 00:53:50,065 OUR WORK FOCUSED ON EXAMINING 1332 00:53:50,065 --> 00:53:51,100 BRAIN STRUCTURES AND FUNCTIONS 1333 00:53:51,100 --> 00:53:54,336 THAT DETERMINE THE DEGREE TO 1334 00:53:54,336 --> 00:53:56,872 WHICH BRAIN DAMAGE WILL RECOVER. 1335 00:53:56,872 --> 00:53:59,942 WORK IS FOCUSED ON SEVERAL YEARS 1336 00:53:59,942 --> 00:54:01,810 OF EXAMINING NATURE OF LANGUAGE 1337 00:54:01,810 --> 00:54:04,380 AND COGNITIVE IMPAIRMENT AND HOW 1338 00:54:04,380 --> 00:54:06,115 THAT EFFECTS ABILITY TO 1339 00:54:06,115 --> 00:54:07,683 SUCCESSFULLY FUNCTION IN THE 1340 00:54:07,683 --> 00:54:08,250 ENVIRONMENT. 1341 00:54:08,250 --> 00:54:09,985 FINALLY QUITE A FEW YEARS 1342 00:54:09,985 --> 00:54:11,520 DEVELOPING EFFECTIVE TREATMENTS 1343 00:54:11,520 --> 00:54:12,554 FOR THESE DEFICITS. 1344 00:54:12,554 --> 00:54:15,824 MORE RECENTLY WE'VE BEEN ABLE TO 1345 00:54:15,824 --> 00:54:16,592 INTEGRATE THESE 1346 00:54:16,592 --> 00:54:17,960 MULTI-DIMENSIONAL FACTORS TO 1347 00:54:17,960 --> 00:54:19,495 DEVELOP MACHINE LEARNING AND 1348 00:54:19,495 --> 00:54:20,229 COMPUTATIONAL ALGORITHMS TO 1349 00:54:20,229 --> 00:54:21,830 PREDICT WHICH OF THESE FACTORS 1350 00:54:21,830 --> 00:54:23,132 ARE IMPORTANT IN PREDICTING 1351 00:54:23,132 --> 00:54:24,700 RECOVERY AND HOW THESE PIECES OF 1352 00:54:24,700 --> 00:54:27,202 INFORMATION CAN THEN ENABLE US 1353 00:54:27,202 --> 00:54:29,271 TO BETTER PREDICT PROGNOSIS AND 1354 00:54:29,271 --> 00:54:30,072 OUTCOME. 1355 00:54:30,072 --> 00:54:33,242 I'M GOING TO GIVE A FEW 1356 00:54:33,242 --> 00:54:33,509 EXAMPLES. 1357 00:54:33,509 --> 00:54:35,110 FIRST EXAMPLE, I'D LIKE TO TELL 1358 00:54:35,110 --> 00:54:36,478 YOU ABOUT HOW WE'RE BUILDING 1359 00:54:36,478 --> 00:54:40,649 DIGITAL TWINS FOR PEOPLE WHO 1360 00:54:40,649 --> 00:54:41,884 SPEAK MULTIPLE LANGUAGES, 1361 00:54:41,884 --> 00:54:43,619 BROADER IMPLICATIONS FOR HOW THE 1362 00:54:43,619 --> 00:54:45,354 BRAIN PROCESSES INFORMATION. 1363 00:54:45,354 --> 00:54:47,122 SO HERE'S THIS COMPUTATIONAL 1364 00:54:47,122 --> 00:54:50,392 MODEL OF HOW A BRAIN CAN THINK 1365 00:54:50,392 --> 00:54:52,761 ABOUT WORDS AND MEANINGS. 1366 00:54:52,761 --> 00:54:54,930 AND IN THIS CASE TRYING TO 1367 00:54:54,930 --> 00:54:57,066 SIMULATE TWO LANGUAGES. 1368 00:54:57,066 --> 00:54:57,599 I'LL SHOW YOU SIMULATION, 1369 00:54:57,599 --> 00:54:59,268 HOPEFULLY CAN YOU SEE IT. 1370 00:54:59,268 --> 00:55:00,803 ON THE LEFT-HAND SIDE COMPUTER 1371 00:55:00,803 --> 00:55:02,905 MODEL IS LEARNING WORDS AND 1372 00:55:02,905 --> 00:55:03,539 MEANINGS. 1373 00:55:03,539 --> 00:55:05,441 ON THE RIGHT SIDE LEARNING 1374 00:55:05,441 --> 00:55:06,175 PHONETIC REPRESENTATIONS IN 1375 00:55:06,175 --> 00:55:10,012 ENGLISH AND SPANISH. 1376 00:55:10,012 --> 00:55:12,147 THIS INFORMATION IS RECEIVING 1377 00:55:12,147 --> 00:55:14,550 MORE INPUT IN SPANISH THAN 1378 00:55:14,550 --> 00:55:18,120 ENGLISH, GOING TO BECOME A 1379 00:55:18,120 --> 00:55:19,088 BILINGUAL, MORE PROFICIENT IN 1380 00:55:19,088 --> 00:55:20,222 ONE LANGUAGE. 1381 00:55:20,222 --> 00:55:25,094 HOPEFULLY YOU CAN SEE THE 1382 00:55:25,094 --> 00:55:25,728 REPRESENTATION. 1383 00:55:25,728 --> 00:55:27,262 WE CAN TAILOR DIGITAL TWIN FOR 1384 00:55:27,262 --> 00:55:32,434 ANY PERSON WHO IS BILINGUAL AND 1385 00:55:32,434 --> 00:55:35,871 VARY THE LEVEL OF PROFICIENCY 1386 00:55:35,871 --> 00:55:36,805 AND EXPOSURE. 1387 00:55:36,805 --> 00:55:39,975 WE'VE DONE THIS IN ENGLISH AND 1388 00:55:39,975 --> 00:55:40,743 SPANISH AND MANDARIN. 1389 00:55:40,743 --> 00:55:44,146 ONCE WE HAVE THESE MODELS, 1390 00:55:44,146 --> 00:55:44,813 ESSENTIALLY LIKE HEALTHY 1391 00:55:44,813 --> 00:55:46,014 BILINGUALS, WE CAN INTRODUCE A 1392 00:55:46,014 --> 00:55:47,750 LESION INTO THE MODEL AND MAKE 1393 00:55:47,750 --> 00:55:53,255 THEM BEHAVE AS IF THEY HAD 1394 00:55:53,255 --> 00:55:54,923 BILINGUAL APHASIA BY TWEAKING 1395 00:55:54,923 --> 00:55:56,225 AMOUNT OF DAMAGE. 1396 00:55:56,225 --> 00:55:57,993 WE CAN RETRAIN THESE MODELS 1397 00:55:57,993 --> 00:56:00,129 SIMILAR TO HOW THEY LEARN 1398 00:56:00,129 --> 00:56:01,597 LANGUAGE AND PREDICT HOW MUCH 1399 00:56:01,597 --> 00:56:03,699 RECOVERY THE MODEL IS GOING TO 1400 00:56:03,699 --> 00:56:05,968 SHOW AND THEN MATCH TO ACTUAL 1401 00:56:05,968 --> 00:56:07,636 INDIVIDUAL PEOPLE. 1402 00:56:07,636 --> 00:56:08,704 WE JUST COMPLETED A RANDOMIZED 1403 00:56:08,704 --> 00:56:11,206 CONTROLLED TRIAL TO SEE IF MODEL 1404 00:56:11,206 --> 00:56:12,574 CAN PREDICT INDIVIDUAL RECOVERY 1405 00:56:12,574 --> 00:56:14,376 PATTERNS AND TURNS OUT IT CAN DO 1406 00:56:14,376 --> 00:56:17,346 A PRETTY GOOD JOB OF DOING THAT. 1407 00:56:17,346 --> 00:56:19,148 AND LASTLY, USING THE SAME 1408 00:56:19,148 --> 00:56:20,549 STARTING POINT OF THE 1409 00:56:20,549 --> 00:56:22,751 COMPUTATIONAL MODEL WE CAN 1410 00:56:22,751 --> 00:56:25,020 CREATE DIGITAL TWINS TO SIMULATE 1411 00:56:25,020 --> 00:56:28,023 DEMENTIA BUT INSTEAD OF SHOWING 1412 00:56:28,023 --> 00:56:30,192 RECOVERY WE CAN SIMULATE DECLINE 1413 00:56:30,192 --> 00:56:33,262 BY INCREASING GRADUALLY THE SIZE 1414 00:56:33,262 --> 00:56:34,463 OF THESE BRAIN LESIONS. 1415 00:56:34,463 --> 00:56:36,331 ANOTHER LINE OF WORK THAT WE'RE 1416 00:56:36,331 --> 00:56:37,800 DOING IS TRYING TO USE 1417 00:56:37,800 --> 00:56:40,669 INFORMATION ABOUT THE BRAIN AND 1418 00:56:40,669 --> 00:56:42,070 ITS INTEGRITY AFTER ITS ROLE TO 1419 00:56:42,070 --> 00:56:42,971 PREDICT RECOVERY. 1420 00:56:42,971 --> 00:56:44,940 IN A PAPER PUBLISHED A FEW YEARS 1421 00:56:44,940 --> 00:56:48,010 AGO WE LOOKED AT HOW AND TO WHAT 1422 00:56:48,010 --> 00:56:49,978 EXTENT STRUCTURAL AND FUNCTIONAL 1423 00:56:49,978 --> 00:56:51,780 INTEGRITY OF THE BRAIN THROUGH 1424 00:56:51,780 --> 00:56:57,419 STROKE COULD PREDICT BENEFIT OF 1425 00:56:57,419 --> 00:56:57,786 THERAPY. 1426 00:56:57,786 --> 00:56:59,488 WE FOUND SIMPLE SUPPORT VECTOR 1427 00:56:59,488 --> 00:57:00,856 MACHINE MODELS DID A GOOD JOB 1428 00:57:00,856 --> 00:57:01,723 CLASSIFYING WHETHER A PATIENT 1429 00:57:01,723 --> 00:57:09,465 WAS GOING TO RECOVER FROM 1430 00:57:09,465 --> 00:57:10,165 APHASIA THERAPY OR NOT, 1431 00:57:10,165 --> 00:57:12,201 STRUCTURE AND FUNCTION WERE THE 1432 00:57:12,201 --> 00:57:14,036 MAIN PREDICTORS. 1433 00:57:14,036 --> 00:57:19,141 THIS WORK EVOLVED INTO MORE 1434 00:57:19,141 --> 00:57:20,542 EFFICIENT DEEP LEARNING MODELS, 1435 00:57:20,542 --> 00:57:22,110 THAT CAN BE AUGMENTED WITH 1436 00:57:22,110 --> 00:57:23,745 SYNTHETIC BRAIN LESIONS TO BE 1437 00:57:23,745 --> 00:57:26,715 ABLE TO PREDICT SEVERITY OF 1438 00:57:26,715 --> 00:57:28,116 APHASIA AND HOW SOMEBODY GOING 1439 00:57:28,116 --> 00:57:29,351 TO RECOVER IN THE THERAPY AS 1440 00:57:29,351 --> 00:57:31,053 WELL IN THE FUTURE. 1441 00:57:31,053 --> 00:57:32,721 LASTLY WE'RE ALSO TRYING TO 1442 00:57:32,721 --> 00:57:38,527 BUILD PERSONALIZED THERAPY 1443 00:57:38,527 --> 00:57:40,963 TRANSLATORS, USING LARGE DATASET 1444 00:57:40,963 --> 00:57:43,866 FROM DIGITAL COMPANY WHICH I 1445 00:57:43,866 --> 00:57:45,367 HELPED CO-FOUND, WHICH HAS ABOUT 1446 00:57:45,367 --> 00:57:48,036 3.5 MILLION THERAPY SESSIONS 1447 00:57:48,036 --> 00:57:50,239 FROM ABOUT 18,000 APP USERS. 1448 00:57:50,239 --> 00:57:52,140 WE'VE DEVELOPED MACHINE LEARNING 1449 00:57:52,140 --> 00:57:53,775 ALGORITHM THAT CAN ESTIMATE 1450 00:57:53,775 --> 00:57:55,177 PROBABILITY OF IMPROVEMENT GOING 1451 00:57:55,177 --> 00:58:00,883 FROM ONE FUNCTIONAL LANDMARK IN 1452 00:58:00,883 --> 00:58:03,285 A GIVEN DOMAIN, WHILE ACCOUNTING 1453 00:58:03,285 --> 00:58:06,588 FOR THINGS LIKE AGE, ETIOLOGY, 1454 00:58:06,588 --> 00:58:07,456 STARTING PERFORMANCE, FREQUENCY 1455 00:58:07,456 --> 00:58:09,258 AND DURATION, SO WHAT YOU SEE IS 1456 00:58:09,258 --> 00:58:11,627 THE RESULT OF THE MACHINE 1457 00:58:11,627 --> 00:58:12,961 LEARNING REGRESSION MODELS THAT 1458 00:58:12,961 --> 00:58:13,462 PREDICT OUTCOMES. 1459 00:58:13,462 --> 00:58:18,066 I WANT TO SHOW A DEMO THAT SHOWS 1460 00:58:18,066 --> 00:58:20,235 USER INTERFACE THAT PEOPLE CAN 1461 00:58:20,235 --> 00:58:21,803 ENTER INFORMATION HERE, AND AS 1462 00:58:21,803 --> 00:58:24,106 IT CALLS BACK THE MACHINE 1463 00:58:24,106 --> 00:58:25,841 LEARNING MODEL, SO HERE YOU CAN 1464 00:58:25,841 --> 00:58:28,343 SEE A PERSON GOING TO THE 1465 00:58:28,343 --> 00:58:29,244 WEBSITE, ENTERED THEIR AGE, HOW 1466 00:58:29,244 --> 00:58:36,752 LONG THEY HAVE HAD THEIR STROKE, 1467 00:58:36,752 --> 00:58:37,853 AND WHICH DOMAIN THEY WANT TO 1468 00:58:37,853 --> 00:58:43,458 WORK O ON. 1469 00:58:43,458 --> 00:58:45,561 IT'S ASKING SUBJECTIVE 1470 00:58:45,561 --> 00:58:47,195 QUESTIONS, SCROLL FORWARD, AND 1471 00:58:47,195 --> 00:58:48,530 IT ASKS SPECIFIC QUESTIONS HOW 1472 00:58:48,530 --> 00:58:49,631 THEY WOULD COMPUTE THE MATH IF 1473 00:58:49,631 --> 00:58:51,667 THEY WERE ASKED TO. 1474 00:58:51,667 --> 00:58:53,435 IN THIS CASE IT'S CALCULATING 1475 00:58:53,435 --> 00:58:54,002 MONEY. 1476 00:58:54,002 --> 00:58:56,104 AND THEN ASKS THEM TO TELL TIME, 1477 00:58:56,104 --> 00:59:01,243 I'M GOING TO SCROLL PAST THAT. 1478 00:59:01,243 --> 00:59:05,514 IT ASKS MORE SOPHISTICATED MATH. 1479 00:59:05,514 --> 00:59:06,348 THIS PREPARES PREDICTIONS BASED 1480 00:59:06,348 --> 00:59:08,550 ON THE ALGORITHM AND TELLS THE 1481 00:59:08,550 --> 00:59:10,018 PATIENT THEIR STARTING POINT IS 1482 00:59:10,018 --> 00:59:11,286 THIS LANDMARK, AND THEY HAVE TO 1483 00:59:11,286 --> 00:59:12,821 MOVE TO THE NEXT LANDMARK. 1484 00:59:12,821 --> 00:59:14,489 NOW IT ASKS THE PATIENT HOW LONG 1485 00:59:14,489 --> 00:59:16,892 DO YOU WANT TO PRACTICE, THE 1486 00:59:16,892 --> 00:59:18,393 PATIENT PICKS FIVE YEARS, I'M 1487 00:59:18,393 --> 00:59:20,462 SORRY, FIVE DAYS A WEEK, FIVE 1488 00:59:20,462 --> 00:59:22,230 WEEKS, MODEL SAYS THAT THAT 1489 00:59:22,230 --> 00:59:24,733 THERAPY PRACTICE IS GOING TO 1490 00:59:24,733 --> 00:59:26,301 ACTUALLY HIGHLY LIKELY RESULT IN 1491 00:59:26,301 --> 00:59:27,703 PRODUCTIVE OUTCOME. 1492 00:59:27,703 --> 00:59:29,004 THESE ARE THE INDIVIDUALIZED 1493 00:59:29,004 --> 00:59:30,339 MODELS WE'RE TRYING TO PREDICT. 1494 00:59:30,339 --> 00:59:33,742 THIS WORK IS NEW AND WE'RE 1495 00:59:33,742 --> 00:59:36,144 TRYING TO OPTIMIZE BUT THIS IS 1496 00:59:36,144 --> 00:59:37,512 THE KIND OF PRECISION 1497 00:59:37,512 --> 00:59:40,415 REHABILITATION WE'RE GOING FOR. 1498 00:59:40,415 --> 00:59:41,650 THANK YOU VERY MUCH. 1499 00:59:41,650 --> 00:59:43,919 >> THANK YOU VERY MUCH. 1500 00:59:43,919 --> 00:59:46,855 THAT WAS FASCINATING. 1501 00:59:46,855 --> 00:59:50,859 ANY QUESTIONS OR DISCUSSION FROM 1502 00:59:50,859 --> 00:59:51,760 COUNCIL ON EITHER PRESENTATION? 1503 00:59:51,760 --> 00:59:53,762 THANK YOU SO MUCH FOR DOING 1504 00:59:53,762 --> 00:59:54,730 THIS. 1505 00:59:54,730 --> 00:59:57,399 IT'S JUST REALLY FUN TO HEAR IN 1506 00:59:57,399 --> 01:00:00,135 MORE DEPTH WHAT MEMBERS OF THE 1507 01:00:00,135 --> 01:00:02,504 COUNCIL DO IN THEIR SCIENTIFIC 1508 01:00:02,504 --> 01:00:02,738 LIVES. 1509 01:00:02,738 --> 01:00:05,974 IT MAKES IT ALL A LITTLE BIT 1510 01:00:05,974 --> 01:00:07,342 EASIER TO APPRECIATE WHAT EVERY 1511 01:00:07,342 --> 01:00:08,777 MEMBER OF OUR COUNCIL DOES. 1512 01:00:08,777 --> 01:00:11,179 THANK YOU VERY MUCH TO BOTH OF 1513 01:00:11,179 --> 01:00:13,415 YOU FOR DOING THAT. 1514 01:00:13,415 --> 01:00:16,652 SO, NOW I THINK WE'RE ALMOST TO 1515 01:00:16,652 --> 01:00:17,919 THE END, AMAZINGLY, SHORT 1516 01:00:17,919 --> 01:00:19,521 MEETING TODAY. 1517 01:00:19,521 --> 01:00:24,993 I WANTED TO END BY THANKING OUR 1518 01:00:24,993 --> 01:00:26,962 RETIRING MEMBER OF COUNCIL, MISS 1519 01:00:26,962 --> 01:00:28,497 VICKIE DEAL WILLIAMS. 1520 01:00:28,497 --> 01:00:30,866 THANK YOU SO MUCH, VICKIE, FOR 1521 01:00:30,866 --> 01:00:33,935 YOUR CONTRIBUTIONS TO COUNCIL. 1522 01:00:33,935 --> 01:00:36,038 YOU'VE BEEN SO THOUGHTFUL AND 1523 01:00:36,038 --> 01:00:37,572 REALLY INFLUENTIAL, I THINK, IN 1524 01:00:37,572 --> 01:00:40,075 MANY OF OUR DISCUSSIONS. 1525 01:00:40,075 --> 01:00:41,910 AND WE TRULY APPRECIATE IT. 1526 01:00:41,910 --> 01:00:44,546 I WANTED TO SEE IF YOU WANTED TO 1527 01:00:44,546 --> 01:00:45,881 SAY A QUICK GOOD-BYE, ANY 1528 01:00:45,881 --> 01:00:47,816 PARTING WORDS THAT YOU HAVE, WE 1529 01:00:47,816 --> 01:00:53,088 WILL CERTAINLY MISS YOU AND YOUR 1530 01:00:53,088 --> 01:01:03,331 CONTRIBUTIONS. 1531 01:01:03,799 --> 01:01:06,702 >> NOT EASY WITH ALL THESE 1532 01:01:06,702 --> 01:01:09,237 BUTTONS. 1533 01:01:09,237 --> 01:01:11,506 THANK YOU, DEB. 1534 01:01:11,506 --> 01:01:13,709 IT HAS TRULY BEEN AN HONOR TO 1535 01:01:13,709 --> 01:01:18,180 SERVE ON THIS COUNCIL, AND IN 1536 01:01:18,180 --> 01:01:23,018 THIS ROLE, AND QUITE A 1537 01:01:23,018 --> 01:01:24,886 RESPONSIBILITY FOR A 1538 01:01:24,886 --> 01:01:28,423 NON-RESEARCHER, EVEN AS A 1539 01:01:28,423 --> 01:01:29,825 SPEECH-LANGUAGE PATHOLOGIST, 1540 01:01:29,825 --> 01:01:32,194 I'VE LEARNED A GREAT DEAL DURING 1541 01:01:32,194 --> 01:01:36,331 THE FOUR YEARS THAT I'VE BEEN IN 1542 01:01:36,331 --> 01:01:37,299 THIS ROLE. 1543 01:01:37,299 --> 01:01:38,734 DURING THAT TIME MY FOCUS HAS 1544 01:01:38,734 --> 01:01:42,537 BEEN ON TRYING TO GET US TO 1545 01:01:42,537 --> 01:01:49,377 THINK ABOUT HOW TO CHANGE THE 1546 01:01:49,377 --> 01:01:53,081 WAY WE LOOK AT THE FACT THAT 1547 01:01:53,081 --> 01:01:56,518 WE'VE BEEN MENTORING AND 1548 01:01:56,518 --> 01:01:57,953 DEVELOPING SPECIFIC PEOPLE INTO 1549 01:01:57,953 --> 01:02:01,356 CONFORMING INTO OUR SYSTEMS AND 1550 01:02:01,356 --> 01:02:04,993 RECOGNIZING THAT OUR SYSTEMS AND 1551 01:02:04,993 --> 01:02:06,428 PROCESSES HAVEN'T NECESSARILY 1552 01:02:06,428 --> 01:02:09,664 EVOLVED WITH THE RESEARCHERS AND 1553 01:02:09,664 --> 01:02:10,699 THE RESEARCH THAT THESE 1554 01:02:10,699 --> 01:02:12,968 INDIVIDUALS HAVE BEEN DOING OR 1555 01:02:12,968 --> 01:02:17,939 LOOKING TO CONDUCT, AND I'M 1556 01:02:17,939 --> 01:02:20,842 GRATEFUL THAT THOSE SENTIMENTS 1557 01:02:20,842 --> 01:02:22,711 HAVE BEEN HEARD AND I THINK 1558 01:02:22,711 --> 01:02:23,145 HEEDED. 1559 01:02:23,145 --> 01:02:24,813 I THINK A LOT OF WORK HAS BEEN 1560 01:02:24,813 --> 01:02:31,553 DONE, A LOT OF CHANGES HAVE BEEN 1561 01:02:31,553 --> 01:02:32,220 MADE. 1562 01:02:32,220 --> 01:02:35,757 AND I THINK THAT A LOT OF THE 1563 01:02:35,757 --> 01:02:38,226 RESEARCH AND THE RESEARCHERS AND 1564 01:02:38,226 --> 01:02:40,662 THE RESEARCH THAT THOSE 1565 01:02:40,662 --> 01:02:42,264 INDIVIDUALS WERE LOOKING TO 1566 01:02:42,264 --> 01:02:45,600 CONDUCT WAS IN THE PIPELINE AND 1567 01:02:45,600 --> 01:02:47,836 MOVING FORWARD. 1568 01:02:47,836 --> 01:02:50,305 AND NOW I HEAR, I UNDERSTAND 1569 01:02:50,305 --> 01:02:52,040 THAT PRIORITIES ARE CHANGING, 1570 01:02:52,040 --> 01:02:55,143 AND THAT THOSE ARE NOT 1571 01:02:55,143 --> 01:02:55,877 NECESSARILY ALIGNED WITH THE 1572 01:02:55,877 --> 01:02:57,412 CURRENT PRIORITIES, BUT THAT 1573 01:02:57,412 --> 01:02:59,714 BRINGS ME TO MY SECOND POINT, 1574 01:02:59,714 --> 01:03:04,219 AND I GUESS MY HOPE FOR WHERE 1575 01:03:04,219 --> 01:03:07,923 THE COUNCIL GOES, AS I LEAVE 1576 01:03:07,923 --> 01:03:08,557 THIS POST. 1577 01:03:08,557 --> 01:03:13,995 AND ALL OF THE PEOPLE IN THIS 1578 01:03:13,995 --> 01:03:18,433 COUNTRY MERIT THE SERVICES THAT 1579 01:03:18,433 --> 01:03:22,037 THIS SCIENCE THAT WE SUPPORT 1580 01:03:22,037 --> 01:03:23,171 PROVIDES. 1581 01:03:23,171 --> 01:03:25,774 AND THOSE PEOPLE AND THAT 1582 01:03:25,774 --> 01:03:28,043 RESEARCH HAS CHANGED OVER TIME. 1583 01:03:28,043 --> 01:03:32,981 IT WILL CONTINUE TO CHANGE OVER 1584 01:03:32,981 --> 01:03:34,182 TIME. 1585 01:03:34,182 --> 01:03:35,250 AND OVER TIME, RECOGNITION THAT 1586 01:03:35,250 --> 01:03:38,320 THERE ARE A LOT OF UNANSWERED 1587 01:03:38,320 --> 01:03:41,189 QUESTIONS RELATED TO THOSE 1588 01:03:41,189 --> 01:03:42,324 POPULATIONS AND THE NUMBER OF 1589 01:03:42,324 --> 01:03:44,159 INITIATIVES THAT HAVE BEEN PUT 1590 01:03:44,159 --> 01:03:51,199 IN PLACE TO CONDUCT RESEARCH AND 1591 01:03:51,199 --> 01:03:53,401 ANSWER QUESTIONS HAS OCCURRED. 1592 01:03:53,401 --> 01:03:56,371 BUT THOSE QUESTIONS NOW ARE 1593 01:03:56,371 --> 01:03:59,574 GOING TO REMAIN UNANSWERED. 1594 01:03:59,574 --> 01:04:02,711 ALL THOSE PEOPLE STILL MERIT 1595 01:04:02,711 --> 01:04:08,416 THAT SERVICE THAT WILL ONLY GET 1596 01:04:08,416 --> 01:04:10,886 ANSWERED IF WE CONTINUE THAT 1597 01:04:10,886 --> 01:04:11,820 RESEARCH. 1598 01:04:11,820 --> 01:04:15,056 THAT RESEARCH IS NEEDED TO GUIDE 1599 01:04:15,056 --> 01:04:16,224 THAT SERVICE. 1600 01:04:16,224 --> 01:04:19,961 THE ONLY WAY THAT NIDCD AND THE 1601 01:04:19,961 --> 01:04:23,431 BROADER NIH CAN ANSWER THOSE 1602 01:04:23,431 --> 01:04:25,400 QUESTIONS IS TO CONTINUE TO 1603 01:04:25,400 --> 01:04:31,039 EVOLVE AND TO LOOK DIFFERENTLY 1604 01:04:31,039 --> 01:04:36,611 AT HOW TO ANSWER THOSE 1605 01:04:36,611 --> 01:04:37,045 QUESTIONS. 1606 01:04:37,045 --> 01:04:38,780 NOT TO NOT ANSWER THEM AT ALL. 1607 01:04:38,780 --> 01:04:40,548 I THINK THAT'S WHAT I WANT TO 1608 01:04:40,548 --> 01:04:42,550 LEAVE EVERYBODY WITH. 1609 01:04:42,550 --> 01:04:44,519 THE ISSUE IS NOT SAYING THINGS 1610 01:04:44,519 --> 01:04:46,554 JUST DON'T ALIGN AND WE CAN'T DO 1611 01:04:46,554 --> 01:04:46,922 THEM. 1612 01:04:46,922 --> 01:04:48,857 IT'S HOW DO WE DO THEM, HOW DO 1613 01:04:48,857 --> 01:04:51,493 WE DO THEM DIFFERENTLY, WHAT ARE 1614 01:04:51,493 --> 01:04:56,631 THE CRITERIA, HOW DO WE DEFINE 1615 01:04:56,631 --> 01:04:59,401 THE CRITERIA SO THAT EVERYBODY 1616 01:04:59,401 --> 01:05:03,538 GETS A PIECE OF THIS PIE, SO 1617 01:05:03,538 --> 01:05:07,876 THAT THE RESEARCH PIE GETS 1618 01:05:07,876 --> 01:05:11,646 DIVIDED UP DIFFERENTLY SO THAT 1619 01:05:11,646 --> 01:05:13,081 EVERYBODY HAS ACCESS. 1620 01:05:13,081 --> 01:05:14,783 AND I THINK THAT, YOU KNOW, THE 1621 01:05:14,783 --> 01:05:18,753 REALITY IS WE HAVE TO LOOK 1622 01:05:18,753 --> 01:05:21,056 DIFFERENTLY AT THE POPULATIONS 1623 01:05:21,056 --> 01:05:22,824 THAT TYPICALLY AND TRADITIONALLY 1624 01:05:22,824 --> 01:05:24,225 AND HISTORICALLY HAVE BEEN 1625 01:05:24,225 --> 01:05:27,329 STUDIED SO THAT WE'RE STUDYING 1626 01:05:27,329 --> 01:05:27,929 EVERYONE. 1627 01:05:27,929 --> 01:05:29,831 BUT THANK YOU FOR THIS 1628 01:05:29,831 --> 01:05:30,365 OPPORTUNITY. 1629 01:05:30,365 --> 01:05:34,202 IT TRULY HAS BEEN A JOY. 1630 01:05:34,202 --> 01:05:36,938 >> THANK YOU SO MUCH. 1631 01:05:36,938 --> 01:05:38,373 REALLY, REALLY THOUGHT-PROVOKING 1632 01:05:38,373 --> 01:05:40,141 COMMENTS AND I APPRECIATE THEM. 1633 01:05:40,141 --> 01:05:40,408 ALL RIGHT. 1634 01:05:40,408 --> 01:05:42,377 I THINK WE'RE AT THE END OF THE 1635 01:05:42,377 --> 01:05:43,044 PROGRAM. 1636 01:05:43,044 --> 01:05:45,580 I GUESS WHAT I'LL LEAVE WITH YOU 1637 01:05:45,580 --> 01:05:47,148 IS JUST A REQUEST TO PLEASE LOOK 1638 01:05:47,148 --> 01:05:48,683 OVER THE SLIDES. 1639 01:05:48,683 --> 01:05:49,584 WE WILL SEND THEM TO YOU. 1640 01:05:49,584 --> 01:05:52,654 LET US KNOW IF YOU HAVE 1641 01:05:52,654 --> 01:05:53,722 QUESTIONS. 1642 01:05:53,722 --> 01:05:57,592 IN PARTICULAR, IF YOU HAVEFULLY 1643 01:05:57,592 --> 01:05:59,627 INTEREST IN PARTICIPATING IN A 1644 01:05:59,627 --> 01:06:01,329 WORK -- HAVE ANY INTEREST IN 1645 01:06:01,329 --> 01:06:03,698 PARTICIPATING IN A WORKING GROUP 1646 01:06:03,698 --> 01:06:05,834 AS A MEMBER OR TO BE INTERVIEWED 1647 01:06:05,834 --> 01:06:06,835 ON CLINICAL TRIALS, PLEASE LET 1648 01:06:06,835 --> 01:06:07,402 ME KNOW. 1649 01:06:07,402 --> 01:06:12,340 THANK YOU VERY MUCH TO DR. 1650 01:06:12,340 --> 01:06:13,274 PICARILLO FOR AGREEING TO 1651 01:06:13,274 --> 01:06:14,309 CO-LEAD THIS EFFORT. 1652 01:06:14,309 --> 01:06:17,712 WE'LL HOPE TO REPORT OUT AT A 1653 01:06:17,712 --> 01:06:19,114 LATER TIME. 1654 01:06:19,114 --> 01:06:20,448 SO, THANK YOU ALL, MEMBERS OF 1655 01:06:20,448 --> 01:06:20,815 COUNCIL. 1656 01:06:20,815 --> 01:06:23,084 THANKS TO EVERYONE WHO HAS 1657 01:06:23,084 --> 01:06:23,418 JOINED TODAY. 1658 01:06:23,418 --> 01:06:26,021 AND I WILL SEE MEMBERS OF 1659 01:06:26,021 --> 01:06:27,689 COUNCIL AGAIN TOMORROW FOR OUR 1660 01:06:27,689 --> 01:06:28,790 SECOND CLOSED SESSION. 1661 01:06:28,790 --> 01:06:30,558 TAKE CARE AND HAVE A GOOD 1662 01:06:30,558 --> 01:06:30,992 EVENING. 1663 01:06:30,992 --> 01:06:31,226 BYE-BYE. 1664 01:06:31,226 --> 01:06:41,536 [END OF PROGRAM]