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WELCOME TO THE OPEN SESSION OF 

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THE NIDCD ADVISORY COUNCIL AND 

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THE OPEN SESSION IS BEING 

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VIDEOCAST LIVE AND WILL BE 

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ARCHIVED FOR VIEWING BY MEMBERS 

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OF THE PUBLIC AND THE NIH STAFF 

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FOR ONE YEAR.

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NEXT, I WANTED TO TAKE A FEW 

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MINUTES SENSE MEMBERS OF THE 

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PUBLIC ARE PRESENT TO INTRODUCE 

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THE COUNCIL MEMBERS.

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I'LL CALL ON EACH MEMBER.

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EMILY BUS.

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>> I'M AT THE UNIVERSITY OF 

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NORTH CAROLINA CHAPEL HILL AND 

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STUDY HUMAN HEARING WITH A FOCUS

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ON SPECIAL HEARING AND 

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PERCEPTION IN CHILDREN AND 

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ADULTS WITHOUT HEARING LOSS.

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>> LARL CARNEY FROM THE 

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DEPARTMENT OF ENGINEERING AND 

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NEUROSCIENCE AT THE UNIVERSITY 

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OF RODCHESTER.

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MY WORK IS ON AUDITORY 

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NEUROSCIENCE AND IN PARTICULAR 

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WE COMBINE PHYSIOLOGICAL 

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COMPUTATIONAL AND BEHAVIORAL 

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MEASURES OF HEARING COMPLEX 

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SOUNDS AND ESPECIALLY DETECTING 

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SIGNALS AND NOISE.

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>> THANK YOU.

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>> HELLO, I'M NARUPA CHUWDRY.

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I STUDY THE TASTE SYSTEM FROM 

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THE RECEPTORS IN THE ORAL CAVITY

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FROM THE MOLECULAR AND 

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ANATOMICAL PERSPECTIVES.

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VERY INTERESTED IN A VARIETY OF 

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CHEMO SENSORY EFFECTS IN PEOPLE 

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AS WELL.

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>> THANK YOU.

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>> I'M VICKY WILLIAMS.

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I'M IN A NEW ROLE AT THE 

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AMERICAN SPEECH LANGUAGE HEARING

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ASSOCIATION.

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MY FORMER ROLE GETS AT MY 

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SUBJECT MATTER EXPERTISE WHICH 

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IS IN CULTURAL LINGUISTIC 

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DIVERSITY.

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I WAS FORMERLY THE CHIEF STAFF 

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OFFICER OF AFFAIRS AND THREE 

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WEEKS IN THE ROLE OF THE CEO OF 

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THAT ASSOCIATION.

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I HAVE SOME PROFESSIONAL 

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MEMBERSHIP ASSOCIATION COMPRISED

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OF SPEECH LANGUAGE PATHOLOGISTS 

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AUDIOLOGISTS.

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>> THANK YOU.

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>> HI, I'M IN THE DEPARTMENT OF 

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NEURAL BIOLOGY AT THE UNIVERSITY

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OF CHICAGO.

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THE WORK IN MY LAB IS FOCUSSED 

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ON THE SENSORY RECEPTORS CELLS 

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OF THE INNER YEAR AND LOOKING AT

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THE -- INNER HERE AND THE 

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VESTIBULAR NEURONS THAT SERVE A 

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SENSE OF BALANCE.

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>> MR. RICHARD EINHORN.

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>> HI, EVERYONE.

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I HAVE A CONSULTING COMPANY 

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CALLED EINHORN CONSULTING AND WE

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DO WORK FOR VARIOUS COMPANIES 

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HEARING HEALTH TECHNOLOGY AND 

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I'M ALSO A HEARING HEALTH 

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ADVOCATE AND PUBLISHED MANY 

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ARTICLES AND GIVE MANY TALKS ON 

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VARIOUS HEARING TECHNOLOGY THAT 

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CAN BE USEFUL FOR PEOPLE.

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>> THANK YOU.

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>> DR. WILSON.

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>> I'M PROFESSOR IN THE 

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ELECTRICAL AND COMPUTER 

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ENGINEERING DEPARTMENT AND THE 

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INSTITUTE FOR SYSTEMS RESEARCH 

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AT THE UNIVERSITY OF MARYLAND 

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COLLEGE PARK.

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I DO FUNDAMENTAL RESEARCH IN 

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SPEECH PRODUCTION, ACOUSTICS AND

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ALSO LOOK AT THE RESEARCH IN 

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OTHER AREAS AND RECENTLY LOOKING

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AT HOW WE CAN USE SPEECH AS A 

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BEHAVIORAL SIGNAL FOR 

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UNDERSTANDING NEURAL MOTOR 

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COORDINATION.

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LOOKING SPECIFICALLY AT MENTAL 

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HEALTH ISSUES SUCH AS 

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DEPRESSION, SCHIZOPHRENIA AND 

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BIPOLARISM.

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>> DR. GOFFMAN.

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>> I'M AT CALIER CENTER AT THE 

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UNIVERSITY OF TEXAS AT DALLAS.

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I STUDY LANGUAGE, SPEECH AND 

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MOTOR DEVELOPMENT IN BOTH CHIP 

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CAL AND ATYPICAL LEARNERS WITH A

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FOCUS ON CHILDREN WITH 

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DEVELOPMENT LANGUAGE DISORDER.

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.

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>> THANK YOU.

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DR. ANDY GROVES.

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>> I'M IN THE DEPARTMENT OF 

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NEUROSCIENCE AND MOLECULAR HUMAN

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GENETICS AT BAYLOR COLLEGE OF 

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MEDICINE IN HOUSTON, TEXAS.

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MY RESEARCH FOR MANY YEARS HAS 

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BEEN INVOLVED IN THE DEVELOPMENT

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AND REGENERATION OF THE INNER 

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EAR BUT RECENTLY MY LAB HAS 

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STARTED TO LOOK AT THE 

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DEVELOPMENT AND HUMAN DISEASES 

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INVOLVED IN THE MIDDLE AND 

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EXTERNAL EARS AS WELL.

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>> THANK YOU.

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DR. HILLIS.

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>> HI, I'M RG HILLIS A PROFESSOR

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OF NEUROLOGY AT JOHNS HOPKINS 

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AND LANGUAGE RECOVERY AFTER 

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STROKE AND STUDY A PHASIA AND 

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DONE SOME CLINICAL TRIALS AND 

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TREATMENT OF APHASIA.

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>> DR. HILLMAN.

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>> I'M THE RESEARCH DIRECTOR AND

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CO-DIRECTOR OF THE CENTER FOR 

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LARYNGEAL VIRGINIA -- SURGERY 

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AND I DIAGNOSE, TREAT AND STUDY 

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LARYNGEAL VOICE DISORDERS.

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>> THANK YOU.

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MS. BARBARA KELLY.

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>> I'M EXECUTIVE DIRECTOR OF THE

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HEARING LOSS ASSOCIATION OF 

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AMERICA.

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WE'RE A CONSUMER ORGANIZATION 

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AND OUR COMMUNITY IS PEOPLE WHO 

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WANT TO STAY IN THE HEARING 

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WORLD WITH TECHNOLOGY.

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WE'RE VERY INTERESTED IN 

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RESEARCH THAT CURES OR ANYTHING 

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TO MITIGATE HEARING LOSS SO 

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PEOPLE CAN LIVE WELL WITH HAIR 

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HEARING LOSS AND WE OPEN THE 

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WORLD OF COMMUNICATION THROUGH 

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INFORMATION, EDUCATION SUPPORT 

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AND ADVOCACY AND HAVE A PUBLIC 

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POLICY AGENDA AT THE NATIONAL 

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LEVEL AND HAVE CHAPTERS ACROSS 

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THE COUNTRY.

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>> GREAT, THANK YOU.

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>> DR. LALWANI.

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>> GOOD AFTERNOON, EVERYBODY.

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I'M AT COLOMBIA UNIVERSITY IN 

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NEW YORK CITY.

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MY RESEARCH PREVIOUSLY FOCUSSED 

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ON DEAFNESS AND GENE THERAPY FOR

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HEARING LOSS.

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MORE RECENTLY WE FOCUSSED ON 

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CREATING THE TOOLS LIKE 

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MICRONEEDLES TO MAKE IT POSSIBLE

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TO OPEN UP TO PRECISION MEDICINE

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OF THE INNER EAR.

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>> VERY GOOD, THANK YOU.

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DR. MORTON.

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>> HI, GOOD AFTERNOON.

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I'M A MEDICAL GENETICIST AT 

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BRIGHAM AND WOMEN'S HOSPITAL AND

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AT HARVARD MEDICAL SCHOOL.

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AS A GENETICIST I'VE HAD A LONG 

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STANDING INTEREST IN THE GENES 

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AND VARIANTS THAT UNDER LIE 

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DEAFNESS AND HARD OF HEARING AND

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WE'RE INTERESTED IN TRYING TO DO

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SOME THERAPY TO GENE THERAPY TO 

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ACTUALLY MITIGATE THE HEARING 

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LOSS.

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ALSO I'M VERY INTERESTED IN 

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IMPLEMENTING GENETICS INTO 

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NEWBORN HEARING SCREENING.

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>> THANK YOU.

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MS. GREENE.

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>> GOOD AFTERNOON.

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I AM AN ATTORNEY BY TRADE AND 

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WORK AS AN UNDER WRITING COUNSEL

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FOR A NATIONAL TITLE COMPANY AND

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LUCKY TO BE A MEMBER OF THIS 

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COUNCIL AND MY PARTICULAR 

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INTEREST AS A PARENT OF A YOUNG 

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CHILD IS ADVOCACY AND WORKING 

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FOR THE COMMUNITY OF THE PEOPLE 

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WITH MY CHILD'S SYNDROME AND FOR

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CHILDREN IN EARLY INTERVENTION 

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FOR HEARING LOSS.

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THANK YOU.

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>> THANK YOU.

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NEXT DR. DAN SINGS.

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>> I'M A PROFESSOR AT THE CENTER

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FOR NEUROSCIENCE AT NEW YORK 

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CITY UNIVERSITY AND BASIC 

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RESEARCH SCIENTIST AND MY WORK 

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CENTERS ON HOW 

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[AUDIO DIGITIZING]

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WHICH IS THE LOSS AND EFFECTS OF

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THE CENTRAL INFORMATION SYSTEM 

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AND THE AFFECTS OF EARLY 

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LEARNING.

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>> THANK YOU, DAN.

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>> DR. STURBRIDGE.

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>> I'M PROFESSOR OF NEUROSCIENCE

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AT CASE WESTERN RESERVE 

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UNIVERSITY IN SNOWY CLEVELAND 

217
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AND WORK ON SYNAPTIC INNER 

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CONNECTIONS AND TRACING THROUGH 

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HOW INFORMATION IS PROCESSED 

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THROUGH CHAIN OF NEURONS AND WE 

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WORK IN A VARIETY OF SYSTEMS.

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THE AREA THAT'S RELEVANT TO THIS

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COMMITTEE IS WE WORK A LOT ON 

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THE OLFACTORY AND TRYING TO 

225
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UNDERSTAND WHAT THE LOCAL 

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CIRCUIT IS DOING AND THE 

227
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COMPUTATION IS.

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>> THANK YOU.

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DR. WALLHAGGEN.

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>> I'M A PROFESSOR IN THE 

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DEPARTMENT OF NURSING AT THE OF 

232
00:11:01,680 --> 00:11:02,800
CALIFORNIA SAN FRANCISCO.

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00:11:02,800 --> 00:11:04,680
I'M IN GERONTOLOGY AND 

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INTERESTED IN HEARING LOSS AND 

235
00:11:06,480 --> 00:11:07,400
THE EXPERIENCE OF HEARING LOSS 

236
00:11:07,400 --> 00:11:11,640
IN OLDER ADULTS AND FROM A 

237
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PRACTITIONER PERSPECTIVE I'M 

238
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EXTREMELY INTERESTED IN THE 

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IMPACT HEARING LOSS ON 

240
00:11:15,680 --> 00:11:16,560
COMMUNICATION WITHIN THE HEALTH 

241
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CARE SYSTEM AND WORKING A LOT ON

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COMMUNICATION ACCESS TRYING TO 

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ASSURE THAT THE COMMUNICATION 

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00:11:24,280 --> 00:11:27,680
WITH PRACTITIONERS IS UNDERSTOOD

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AND SO PEOPLE GET THEIR WISHES 

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ADDRESSED AND HEARING LOSS IS 

247
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PAID ATTENTION TO AND THAT 

248
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INCLUDES THE FACT I DO A LOT OF 

249
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TEACHING FOR PRACTITIONERS TO 

250
00:11:39,000 --> 00:11:40,400
HELP THEM UNDERSTAND BETTER THE 

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IMPACT OF HEARING LOSS ON OLDER 

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ADULTS.

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>> THANK YOU, MEG.

254
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>> AND WE HAVE THREE EX-OFFICIO 

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MEMBERS.

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DR. BECK FROM THE DEPARTMENT OF 

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VETERAN AFFAIRS.

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IS DR. BECK HERE?

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OR DR. SCHAEFER FOR DR. BECK?

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00:12:04,080 --> 00:12:04,920
>> I'M HERE.

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>> I'M A REHAB SPECIALIST FOR 

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00:12:17,640 --> 00:12:19,480
THE DEPARTMENT OF VETERANS 

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00:12:19,480 --> 00:12:21,360
AFFAIRS IN WASHINGTON, D.C. AND 

264
00:12:21,360 --> 00:12:22,880
WORK IN POLICY AND PLANNING AND 

265
00:12:22,880 --> 00:12:25,880
SEVERAL AREAS WITH THE PROGRAM 

266
00:12:25,880 --> 00:12:29,120
OFFICE INCLUDING HEARING 

267
00:12:29,120 --> 00:12:29,760
CONSERVATION, TELEHEALTH, RURAL 

268
00:12:29,760 --> 00:12:31,560
HEALTH AND EDUCATION, 

269
00:12:31,560 --> 00:12:32,680
COMPENSATION AND HEARING AND 

270
00:12:32,680 --> 00:12:35,720
HEARING AIDS AND SPECIAL 

271
00:12:35,720 --> 00:12:36,160
DISABILITIES.

272
00:12:36,160 --> 00:12:37,360
>> THANK YOU.

273
00:12:37,360 --> 00:12:38,680
DR. NELSON FROM THE DEPARTMENT 

274
00:12:38,680 --> 00:12:47,160
OF DEFENSE.

275
00:12:47,160 --> 00:12:50,200
>> I SERVE AT THE HEARING CENTER

276
00:12:50,200 --> 00:12:52,320
OF EXCELLENCE AND FOCUS ON 

277
00:12:52,320 --> 00:12:54,360
HEALTH IN SERVICE MEMBERS AND 

278
00:12:54,360 --> 00:12:55,760
BENEFICIARIES AND VETERANS AND 

279
00:12:55,760 --> 00:13:00,920
RECENTLY BEEN TASKED WITH 

280
00:13:00,920 --> 00:13:06,560
GUIDING THE PROGRAM.

281
00:13:06,560 --> 00:13:09,360
>> LAST, MS. FREEMAN.

282
00:13:09,360 --> 00:13:11,800
>> I'M FROM THE NATIONAL 

283
00:13:11,800 --> 00:13:14,200
INSTITUTE FOR OCCUPATIONAL 

284
00:13:14,200 --> 00:13:16,280
SAFETY AND HEALTH AND 

285
00:13:16,280 --> 00:13:17,960
AUDIOLOGIST THAT WORKS ON THE 

286
00:13:17,960 --> 00:13:21,320
NOISE AND ACOUSTIC TEAM AND WORK

287
00:13:21,320 --> 00:13:24,040
ON PREVENTING HEARING LOSS ON 

288
00:13:24,040 --> 00:13:26,600
WORKERS FROM EXPOSURE AND LOOK 

289
00:13:26,600 --> 00:13:29,960
AT EPI STUDIES OF HEARING LOSS.

290
00:13:29,960 --> 00:13:30,280
>>.

291
00:13:30,280 --> 00:13:31,840
THANK YOU FOR THE INTRODUCTIONS.

292
00:13:31,840 --> 00:13:35,920
NEXT WE'LL MOVE ON TO 

293
00:13:35,920 --> 00:13:41,000
CONSIDERATION OF THE MINUTES AND

294
00:13:41,000 --> 00:13:43,160
THE MINUTES OF THE COUNCIL 

295
00:13:43,160 --> 00:13:46,880
RECENTLY POSTED ON THE ADVISORY 

296
00:13:46,880 --> 00:13:48,840
COUNCIL WEBSITE AND I'M 

297
00:13:48,840 --> 00:13:49,840
WONDERING IF ANYONE HAS 

298
00:13:49,840 --> 00:13:50,640
ADDITIONS OR CORRECTIONS TO 

299
00:13:50,640 --> 00:13:59,760
THESE MINUTES.

300
00:13:59,760 --> 00:14:02,000
HEARING NONE, IS THERE A MOTION 

301
00:14:02,000 --> 00:14:03,080
THEY BE APPROVED AS WRITTEN.

302
00:14:03,080 --> 00:14:09,360
THANK YOU.

303
00:14:09,360 --> 00:14:10,960
IS ANYONE IN FAVOR?

304
00:14:10,960 --> 00:14:17,520
WE'RE GOOD WITH THE VOTE.

305
00:14:17,520 --> 00:14:19,560
>> AND THE LAST ADMINISTRATIVE 

306
00:14:19,560 --> 00:14:21,680
ISSUE IS DATES OF FUTURE 

307
00:14:21,680 --> 00:14:24,920
MEETINGS OF THIS COUNCIL.

308
00:14:24,920 --> 00:14:26,920
COUNCIL MEETING DATES ARE POSTED

309
00:14:26,920 --> 00:14:28,800
THROUGH 2023 AND THESE ARE 

310
00:14:28,800 --> 00:14:30,760
LISTED ON THE SLIDE AND IN YOUR 

311
00:14:30,760 --> 00:14:32,280
WORKBOOK.

312
00:14:32,280 --> 00:14:34,560
THE NEXT MEETING OF THIS COUNCIL

313
00:14:34,560 --> 00:14:36,760
WILL BE MAY 19 AND 20 AND SADLY 

314
00:14:36,760 --> 00:14:38,200
WE WERE HOPING FOR AN IN PERSON 

315
00:14:38,200 --> 00:14:44,280
MEETING BUT THE NIH CAME OUT 

316
00:14:44,280 --> 00:14:45,720
THIS WEEK SAYING WE'D CONTINUE 

317
00:14:45,720 --> 00:14:46,640
WITH VIRTUAL MEETINGS AT LEAST 

318
00:14:46,640 --> 00:14:48,160
THROUGH THE SUMMER.

319
00:14:48,160 --> 00:14:49,960
SO ONE MORE VIRTUAL MEETING AND 

320
00:14:49,960 --> 00:14:59,360
HOPEFULLY THAT'S IT.

321
00:14:59,360 --> 00:15:01,240
 I WAS GOING TO TRY TO PROVIDE 

322
00:15:01,240 --> 00:15:03,520
UPDATES AND I WAS GOING TO 

323
00:15:03,520 --> 00:15:05,920
TRUNCATE THE REPORT BECAUSE I 

324
00:15:05,920 --> 00:15:08,160
THINK DR. HODES IS PROBABLY 

325
00:15:08,160 --> 00:15:08,360
HERE.

326
00:15:08,360 --> 00:15:19,960
LET'S GO TO THE NEXT SLIDE.

327
00:15:19,960 --> 00:15:21,400
I WANTED TO BEGIN BY THANKING 

328
00:15:21,400 --> 00:15:22,920
DR. COLLINS AND ACKNOWLEDGING 

329
00:15:22,920 --> 00:15:25,120
HIS 12 YEARS OF SERVICE AS 

330
00:15:25,120 --> 00:15:25,560
DIRECTOR OF THE NIH.

331
00:15:25,560 --> 00:15:30,360
I THINK MOST OF YOU KNOW THIS IS

332
00:15:30,360 --> 00:15:32,480
A PRESIDENTIAL APPOINTMENT AND 

333
00:15:32,480 --> 00:15:33,920
HE'S THE ONLY NIH DIRECTOR TO 

334
00:15:33,920 --> 00:15:35,520
HAVE SERVED UNDER MORE THAN ONE 

335
00:15:35,520 --> 00:15:35,880
ADMINISTRATION.

336
00:15:35,880 --> 00:15:38,360
HE WAS APPOINTED BY PRESIDENT 

337
00:15:38,360 --> 00:15:42,760
OBAMA AND THEN SERVED IN THE 

338
00:15:42,760 --> 00:15:43,360
ADMINISTRATIONS OF PRESIDENT 

339
00:15:43,360 --> 00:15:46,160
TRUMP AND NOW PRESIDENT BIDEN.

340
00:15:46,160 --> 00:15:49,600
THE NIH HELD A VIRTUAL FAREWELL 

341
00:15:49,600 --> 00:15:51,680
TO CELEBRATE DR. COLLINS' 

342
00:15:51,680 --> 00:15:54,320
REMARKABLE TENURE AND MANY 

343
00:15:54,320 --> 00:15:57,320
PEOPLE GAVE TRIBUTES INCLUDING 

344
00:15:57,320 --> 00:16:01,960
JANE GOODALL AND HENRY LEWIS 

345
00:16:01,960 --> 00:16:03,680
BATES JUNIOR AND INVITE TO YOU 

346
00:16:03,680 --> 00:16:06,080
LOOK AT THAT POST ON THE NIH 

347
00:16:06,080 --> 00:16:08,360
WEBSITE AS WELL AS THE JOYED 

348
00:16:08,360 --> 00:16:10,560
CAST YOUTUBE CHANNEL.

349
00:16:10,560 --> 00:16:13,480
ON DECEMBER 20, DR. LARRY TABAK 

350
00:16:13,480 --> 00:16:16,320
ASSUMED THE ROLE OF ACTING 

351
00:16:16,320 --> 00:16:23,840
DIRECTOR OF THE NIH TO LEAD THE 

352
00:16:23,840 --> 00:16:27,360
ADMINISTRATION AND HAS SERVED AS

353
00:16:27,360 --> 00:16:29,640
DEPUTY DIRECTOR SINCE AUGUST 

354
00:16:29,640 --> 00:16:34,200
2010 AND FOR 10 YEARS WAS THE 

355
00:16:34,200 --> 00:16:37,080
DIRECTOR OF INSTITUTE OF 

356
00:16:37,080 --> 00:16:40,360
CRANIOFACIAL RESEARCH AND WILL 

357
00:16:40,360 --> 00:16:43,360
SUSTAIN DR. COLLINS' LEGACY 

358
00:16:43,360 --> 00:16:46,320
DURING THIS TIME OF RESEARCH.

359
00:16:46,320 --> 00:16:49,920
I'D LIKE TO RECOGNIZE THE RECENT

360
00:16:49,920 --> 00:16:54,400
APPOINTMENT OF MS. KARIMBAKAS.

361
00:16:54,400 --> 00:17:00,240
SHE CAME TO US FROM THE NIDDK IN

362
00:17:00,240 --> 00:17:02,960
2015 AND SHE LED THE TEAM THAT 

363
00:17:02,960 --> 00:17:04,800
PRODUCED THE VIDEO JOURNEY OF 

364
00:17:04,800 --> 00:17:06,240
SOUND TO THE BRAIN WHICH HAS 

365
00:17:06,240 --> 00:17:08,200
RECEIVED MILLIONS OF VIEWS ON 

366
00:17:08,200 --> 00:17:12,160
YOUTUBE AND FORMALLY ASSUMED HER

367
00:17:12,160 --> 00:17:14,480
ROLE OF CHIEF OF THIS OFFICE 

368
00:17:14,480 --> 00:17:16,160
JANUARY 3 THIS YEAR AND I LOOK 

369
00:17:16,160 --> 00:17:22,080
FORWARD TO CONTINUING TO WORK 

370
00:17:22,080 --> 00:17:27,520
WITH JOANNE IN THIS ROLE.

371
00:17:27,520 --> 00:17:31,360
I'LL SKIP THE NEXT SLIDE BECAUSE

372
00:17:31,360 --> 00:17:33,560
BEFORE BERNARD WILL BE HERE TO 

373
00:17:33,560 --> 00:17:35,320
TALK ABOUT IT IN MORE DETAIL 

374
00:17:35,320 --> 00:17:37,080
LATER TODAY.

375
00:17:37,080 --> 00:17:39,960
I WANTED TO MENTION A COUPLE 

376
00:17:39,960 --> 00:17:42,080
VIDEOCASTS WE HAVE DEVELOPED.

377
00:17:42,080 --> 00:17:45,120
THE FIRST WAS TO DISCUSS OUR 

378
00:17:45,120 --> 00:17:45,800
PROGRAMS AND TRAINING OF 

379
00:17:45,800 --> 00:17:51,440
CLINICIAN SCIENTISTS AND SURGEON

380
00:17:51,440 --> 00:17:55,280
SCIENTISTS WITH THREE NEW 

381
00:17:55,280 --> 00:17:59,160
PROGRAMS DEVELOPED WITH OUR 

382
00:17:59,160 --> 00:18:00,120
NIDCD EXTRAMURAL TRAINING 

383
00:18:00,120 --> 00:18:00,360
OFFICER.

384
00:18:00,360 --> 00:18:04,040
HE AND I HOSTED A WEBINAR THIS 

385
00:18:04,040 --> 00:18:06,800
PAST OCTOBER TO FURTHER DISCUSS 

386
00:18:06,800 --> 00:18:07,960
THE PROGRAMS WHICH SUPPORT 

387
00:18:07,960 --> 00:18:09,680
RESEARCH EXPERIENCES AND 

388
00:18:09,680 --> 00:18:11,680
MENTORING NETWORKS AND RESEARCH 

389
00:18:11,680 --> 00:18:16,480
TRAINING FOR THIS GROUP AND THEN

390
00:18:16,480 --> 00:18:20,160
NEXT IS SHOWING ADDITIONAL 

391
00:18:20,160 --> 00:18:22,160
PROGRAMS THAT WE HOPE WILL 

392
00:18:22,160 --> 00:18:25,160
PROMOTE OUR EFFORTS TO TRAINING 

393
00:18:25,160 --> 00:18:28,280
A DIVERSE WORKFORCE.

394
00:18:28,280 --> 00:18:31,680
SO THESE PROGRAMS ARE TARGETING 

395
00:18:31,680 --> 00:18:36,200
INDIVIDUALS FROM UNDER 

396
00:18:36,200 --> 00:18:37,440
REPRESENTED GROUPS AND 

397
00:18:37,440 --> 00:18:39,320
INDIVIDUALS WITH HEARING LOSS 

398
00:18:39,320 --> 00:18:40,960
AND THOSE FROM DISADVANTAGED 

399
00:18:40,960 --> 00:18:42,680
BACKGROUNDS AND WOMEN.

400
00:18:42,680 --> 00:18:45,160
THESE PROGRAMS ARE FOCUSSED ON 

401
00:18:45,160 --> 00:18:47,800
THE GRADUATE AND FACULTY LEVEL 

402
00:18:47,800 --> 00:18:49,560
AND FOCUSSED AGAIN ON VENTURING 

403
00:18:49,560 --> 00:18:51,160
AND RESEARCH EXPERIENCES.

404
00:18:51,160 --> 00:18:54,640
WE PLAN TO PRESENT A WEBINAR TO 

405
00:18:54,640 --> 00:18:55,640
FURTHER DISCUSS THESE PROGRAMS 

406
00:18:55,640 --> 00:18:59,000
ON FEBRUARY 25.

407
00:18:59,000 --> 00:19:01,840
LAST, OUR STRATEGIC PLAN IS WELL

408
00:19:01,840 --> 00:19:02,120
UNDERWAY.

409
00:19:02,120 --> 00:19:03,560
WE HAVE COMPLETE THE FIRST TWO 

410
00:19:03,560 --> 00:19:06,360
MAJOR COMPONENTS OF THIS PROGRAM

411
00:19:06,360 --> 00:19:10,200
IN JULY AND THEN THIS PAST 

412
00:19:10,200 --> 00:19:11,520
DECEMBER.

413
00:19:11,520 --> 00:19:15,600
AND DR. LARA COLE ALONG WITH OUR

414
00:19:15,600 --> 00:19:20,320
LIAISONS WILL BE GIVING A MORE 

415
00:19:20,320 --> 00:19:22,320
DETAILED UPDATE LATER TODAY.

416
00:19:22,320 --> 00:19:25,160
THAT IS A VERY QUICK UPDATE AND 

417
00:19:25,160 --> 00:19:29,400
I WANTED TO GO AHEAD AND PROCEED

418
00:19:29,400 --> 00:19:32,960
TO WELCOME DR. RICHARD HODES.

419
00:19:32,960 --> 00:19:34,960
DR. HODES IS THE DIRECTOR OF THE

420
00:19:34,960 --> 00:19:37,760
NATIONAL INSTITUTE ON AGING OR 

421
00:19:37,760 --> 00:19:41,760
THE NIA, WHERE HE'S BEEN 

422
00:19:41,760 --> 00:19:43,640
DIRECTOR SINCE 1993.

423
00:19:43,640 --> 00:19:46,520
IT LEADS THE GOVERNMENT'S 

424
00:19:46,520 --> 00:19:48,760
SUPPORT AND RESEARCH ON THE 

425
00:19:48,760 --> 00:19:50,920
BIOLOGICAL, CLINICAL AND 

426
00:19:50,920 --> 00:19:53,840
BEHAVIORAL AND SOCIAL ASPECTS OF

427
00:19:53,840 --> 00:19:55,600
AGING AND LEADING THE FROM 

428
00:19:55,600 --> 00:19:57,400
EFFORT TO FIND EFFECTIVE WAYS TO

429
00:19:57,400 --> 00:19:58,360
TREAT OR PREVENT ALZHEIMER'S 

430
00:19:58,360 --> 00:19:58,680
DISEASE.

431
00:19:58,680 --> 00:20:02,360
IN ADDITION TO HIS LEADERSHIP AT

432
00:20:02,360 --> 00:20:04,520
NIA, HE MAINTAINS A RESEARCH 

433
00:20:04,520 --> 00:20:05,760
LABORATORY AT THE NATIONAL 

434
00:20:05,760 --> 00:20:06,800
CANCER INSTITUTE WHICH IS 

435
00:20:06,800 --> 00:20:09,360
FOCUSSED ON THE CELLULAR AND 

436
00:20:09,360 --> 00:20:11,480
MOLECULAR MECHANISMS THAT 

437
00:20:11,480 --> 00:20:12,880
REGULATE THE IMMUNE RESPONSE.

438
00:20:12,880 --> 00:20:15,360
RICHARD, WE LOOK FORWARD TO 

439
00:20:15,360 --> 00:20:17,000
HEARING WHAT YOU HAVE TO SHARE 

440
00:20:17,000 --> 00:20:18,640
AND TO CONTINUING TO FIND WAYS 

441
00:20:18,640 --> 00:20:20,960
THAT WE CAN PARTNER WITH THE 

442
00:20:20,960 --> 00:20:21,160
NIA.

443
00:20:21,160 --> 00:20:23,600
WELCOME.

444
00:20:23,600 --> 00:20:24,960
>> THANK YOU, I APPRECIATE THE 

445
00:20:24,960 --> 00:20:27,120
CHANCE TO SPEAK WITH YOU AND 

446
00:20:27,120 --> 00:20:28,960
COUNCIL AS YOU SAY TO LET PEOPLE

447
00:20:28,960 --> 00:20:33,560
KNOW OF THE GREAT HISTORY AND 

448
00:20:33,560 --> 00:20:34,720
CURRENT INTEREST IN FUTURE WITH 

449
00:20:34,720 --> 00:20:35,720
OUR INSTITUTES WORKING CLOSELY 

450
00:20:35,720 --> 00:20:37,360
TOGETHER.

451
00:20:37,360 --> 00:20:40,680
THIS IS JUST AN ILLUSTRATE OF 

452
00:20:40,680 --> 00:20:42,240
NIA'S ORGANIZATIONAL STRUCTURE.

453
00:20:42,240 --> 00:20:45,680
MAYBE MOST RELEVANT IS TO NOTE 

454
00:20:45,680 --> 00:20:51,640
AS THE CASE FOR NIDDK WE HAVE A 

455
00:20:51,640 --> 00:20:55,160
RANGE OF BIOLOGY OF AGING, 

456
00:20:55,160 --> 00:20:56,880
GERIATRICS AND NEUROSCIENCE AND 

457
00:20:56,880 --> 00:20:57,880
BEHAVIORAL RESEARCH.

458
00:20:57,880 --> 00:20:59,840
WE SHARE OPPORTUNITIES AND 

459
00:20:59,840 --> 00:21:00,480
INTERACTIONS WITH YOU ACROSS 

460
00:21:00,480 --> 00:21:04,840
THESE MANY DIMENSIONS OF 

461
00:21:04,840 --> 00:21:05,960
BIOMEDICAL BEHAVIORAL RESEARCH.

462
00:21:05,960 --> 00:21:09,960
SO PROENGS 

463
00:21:11,920 --> 00:21:18,880
APPROPRIATIONS AND SPENDING.

464
00:21:18,880 --> 00:21:20,760
NIA HAS GONE UNDER AN 

465
00:21:20,760 --> 00:21:22,280
UNPRECEDENTED FUNDING.

466
00:21:22,280 --> 00:21:24,880
AS RECENTLY AS 20 AND 

467
00:21:24,880 --> 00:21:27,560
APPROPRIATION LEVEL WAS $1 

468
00:21:27,560 --> 00:21:30,280
BILLION AND NOW IN 2021 

469
00:21:30,280 --> 00:21:32,240
APPROACHING $4 BILLION.

470
00:21:32,240 --> 00:21:36,760
SINCE 2015 AND THIS WAS AN 

471
00:21:36,760 --> 00:21:39,280
INCREASE IN WHAT WE CAN SUPPORT 

472
00:21:39,280 --> 00:21:41,240
AND FOR INTERACTIONS WITH NIDDK 

473
00:21:41,240 --> 00:21:42,960
AND OTHER INSTITUTES AN 

474
00:21:42,960 --> 00:21:43,840
OPPORTUNITY TO COLLABORATE TO 

475
00:21:43,840 --> 00:21:47,360
MAKE BEST USE OF THE KIND OF 

476
00:21:47,360 --> 00:21:49,080
RESEARCH THAT IS BEING SUPPORTED

477
00:21:49,080 --> 00:21:51,360
BY OUR DOLLARS AND THE CHARGE 

478
00:21:51,360 --> 00:21:53,920
THAT COMES FROM CONGRESSIONAL 

479
00:21:53,920 --> 00:21:57,880
APPROPRIATIONS AND PRIORITIES.

480
00:21:57,880 --> 00:22:00,320
SO EVEN AS WE EXPAND OUR 

481
00:22:00,320 --> 00:22:04,720
RESEARCH, IF YOU LOOK AT THE NIH

482
00:22:04,720 --> 00:22:05,560
WIDE RESEARCH PORTFOLIO IN 

483
00:22:05,560 --> 00:22:07,560
COMPETING AWARDS, THESE ARE NEW 

484
00:22:07,560 --> 00:22:09,360
AWARDS GIVEN OUT EACH HERE.

485
00:22:09,360 --> 00:22:12,280
IF YOU LOOK AT 2011 THERE'S 

486
00:22:12,280 --> 00:22:16,080
ABOUT $100 MILLION OF COMPETING 

487
00:22:16,080 --> 00:22:20,560
AWARDS FOR NIH AND ALZHEIMERS 

488
00:22:20,560 --> 00:22:24,040
RELATED DEMENTIA AND THIS 

489
00:22:24,040 --> 00:22:24,800
ILLUSTRATE THE APPROPRIATION.

490
00:22:24,800 --> 00:22:27,760
A LOT OF THIS HAS BEEN TARGETED 

491
00:22:27,760 --> 00:22:29,720
FUNDING FOR ALZHEIMER'S FUNDING 

492
00:22:29,720 --> 00:22:31,160
RELATED RESEARCH AND THE COLORED

493
00:22:31,160 --> 00:22:33,840
BARS SHOWS THE SPECTRUM FROM THE

494
00:22:33,840 --> 00:22:37,320
BASIC MOLECULAR PATHOGENESIS 

495
00:22:37,320 --> 00:22:38,600
THROUGH DIAGNOSIS, MONITORING 

496
00:22:38,600 --> 00:22:44,000
AND TRIALS AND PARALLELING THE 

497
00:22:44,000 --> 00:22:44,840
INTERVENTION AND BASIC SCIENCE 

498
00:22:44,840 --> 00:22:49,800
WHICH IS PART OF THE PORTFOLIO.

499
00:22:49,800 --> 00:22:52,360
AS WE SPEND OF COURSE WE HAVE 

500
00:22:52,360 --> 00:22:55,960
BEGUN WITH PEOPLE ALREADY 

501
00:22:55,960 --> 00:22:58,680
WORKING IN ALZHEIMERS RELATED 

502
00:22:58,680 --> 00:23:00,320
RESEARCH AND IT'S IMPORTANT TO 

503
00:23:00,320 --> 00:23:02,040
TRACK AND MAKE EFFORTS TO BRING 

504
00:23:02,040 --> 00:23:06,760
NEW PEOPLE INTO THE FIELD OF 

505
00:23:06,760 --> 00:23:07,360
ALZHEIMER'S RELATED DEMENTIA 

506
00:23:07,360 --> 00:23:09,800
RESEARCH AND AS WE LOOK FROM 

507
00:23:09,800 --> 00:23:14,680
2015 TO 2020 A THIRD OF THE 

508
00:23:14,680 --> 00:23:18,800
RELATED DEMENTIA AWARDEE NEW OR 

509
00:23:18,800 --> 00:23:20,920
EARLY STAGE INVESTIGATORS AND WE

510
00:23:20,920 --> 00:23:22,520
LOOKED AT ANOTHER CATEGORY NEW 

511
00:23:22,520 --> 00:23:23,160
TO THE FIELD.

512
00:23:23,160 --> 00:23:25,120
THIS WAS DEFINED BY INDIVIDUAL 

513
00:23:25,120 --> 00:23:29,000
WHO'S HAD NEVER EVEN APPLIED FOR

514
00:23:29,000 --> 00:23:31,280
RESEARCH IN ALZHEIMER'S DISEASE 

515
00:23:31,280 --> 00:23:32,760
BEFORE AND ABOUT A FOURTH OVER 

516
00:23:32,760 --> 00:23:33,320
THIS PERIOD WERE TO THESE 

517
00:23:33,320 --> 00:23:37,320
INVESTIGATORS.

518
00:23:37,320 --> 00:23:39,760
I POINT THIS OUT BECAUSE IT'S 

519
00:23:39,760 --> 00:23:40,600
RELEVANT FOR THE OPPORTUNITIES 

520
00:23:40,600 --> 00:23:41,840
TO NIDDK FUNDED INVESTIGATORS 

521
00:23:41,840 --> 00:23:44,880
AND PEOPLE WORKING IN THE AREAS 

522
00:23:44,880 --> 00:23:47,000
OF RESEARCH AND INSTITUTES WE 

523
00:23:47,000 --> 00:23:47,640
SUPPORT PART OF THIS EFFORT AS 

524
00:23:47,640 --> 00:23:50,120
WELL.

525
00:23:50,120 --> 00:23:53,080
SO AMONG THE WAYS IN WHICH WE 

526
00:23:53,080 --> 00:23:54,800
WANTED TO MAXIMIZE THE 

527
00:23:54,800 --> 00:23:55,760
INVOLVEMENT OF RESEARCHERS 

528
00:23:55,760 --> 00:23:57,520
ACROSS ALL THE INSTITUTES OF NIH

529
00:23:57,520 --> 00:24:01,040
WAS THIS PROGRAM IN WHICH WE 

530
00:24:01,040 --> 00:24:03,600
OFFERED TO FUND ADMINISTRATIVE 

531
00:24:03,600 --> 00:24:05,560
SUPPLEMENTS TO THE GRANTS OF ANY

532
00:24:05,560 --> 00:24:10,320
INSTITUTE AND CENTER WERE 

533
00:24:10,320 --> 00:24:11,360
THEMSELVES NOT ALZHEIMER'S 

534
00:24:11,360 --> 00:24:13,000
RELATED DEMENTIAS SPECIFIC BUT 

535
00:24:13,000 --> 00:24:14,200
WITHIN THE SCOPE OF THE ORIGINAL

536
00:24:14,200 --> 00:24:15,760
GRANT THERE WAS THE OPPORTUNITY 

537
00:24:15,760 --> 00:24:18,680
TO EXPAND RESEARCH AND MAKE IT 

538
00:24:18,680 --> 00:24:20,520
RELEVANT EXPLICITLY ALZHEIMER'S 

539
00:24:20,520 --> 00:24:20,760
DISEASE.

540
00:24:20,760 --> 00:24:25,040
FOR EXAMPLE, THIS LAST YEAR IN 

541
00:24:25,040 --> 00:24:27,480
2021 WE FUNDED 267 SUPPLEMENTS 

542
00:24:27,480 --> 00:24:29,760
ACROSS ALL THE INSTITUTES AND 

543
00:24:29,760 --> 00:24:32,760
NIA AND TOTAL ABOUT $89 MILLION.

544
00:24:32,760 --> 00:24:34,320
YOU SEE NIDDK, FOR EXAMPLE, 

545
00:24:34,320 --> 00:24:35,040
THERE WERE 12 SUPPLEMENTS 

546
00:24:35,040 --> 00:24:38,360
FUNDED.

547
00:24:38,360 --> 00:24:42,200
NEXT SLIDE LOOKS AT THE WAYS IN 

548
00:24:42,200 --> 00:24:44,440
WHICH INCLUDING THIS WE HAVE 

549
00:24:44,440 --> 00:24:45,720
FUNDED RESEARCH OF OTHER 

550
00:24:45,720 --> 00:24:46,880
INSTITUTE SINCE 2016 WHEN THE 

551
00:24:46,880 --> 00:24:53,240
INCREASE IN TARGETED RESEARCH TO

552
00:24:53,240 --> 00:24:55,680
ALZHEIMER'S DISEASE CAME TO NIA 

553
00:24:55,680 --> 00:24:58,120
AND EACH YEAR THERE'S BEEN 

554
00:24:58,120 --> 00:24:59,800
SUBSTANTIAL FUNDING OF RESEARCH 

555
00:24:59,800 --> 00:25:01,600
SOME BY SUPPLEMENTS OTHER BY 

556
00:25:01,600 --> 00:25:03,600
CO-FUNDING AND OTHERS BY FUNDING

557
00:25:03,600 --> 00:25:05,480
APPLICATIONS THAT ARE BEYOND THE

558
00:25:05,480 --> 00:25:09,760
PAY LINE FOR NIDDK WHICH ARE 

559
00:25:09,760 --> 00:25:12,480
RELEVANT TO ALZHEIMER'S RELATED 

560
00:25:12,480 --> 00:25:15,320
DEMENTIA AND THIS TO ENCOURAGE 

561
00:25:15,320 --> 00:25:15,960
OPPORTUNITIES TO WORK TOGETHER 

562
00:25:15,960 --> 00:25:20,800
IN THIS DOMAIN.

563
00:25:20,800 --> 00:25:24,200
THEN THE THEME OF HEALTH EQUITY 

564
00:25:24,200 --> 00:25:25,200
MENTIONED.

565
00:25:25,200 --> 00:25:28,200
OUR PREVIOUS DEPUTY DIRECTOR 

566
00:25:28,200 --> 00:25:30,080
WILL BE SPEAKING WITH YOU TOO 

567
00:25:30,080 --> 00:25:34,200
AND THIS IS THE HEART OF OUR 

568
00:25:34,200 --> 00:25:37,200
MISSION ILLUSTRATING SOME ASPECT

569
00:25:37,200 --> 00:25:37,760
OF IT.

570
00:25:37,760 --> 00:25:39,520
ONE OF THE CHALLENGES WE FACE 

571
00:25:39,520 --> 00:25:42,640
AROUND DIVERSITY AND INCLUSION 

572
00:25:42,640 --> 00:25:44,320
HAS BEEN IN OUR CLINICAL 

573
00:25:44,320 --> 00:25:46,160
RESEARCH AND TRIALS.

574
00:25:46,160 --> 00:25:49,000
A LOT OF EFFORT TO DO BETTER 

575
00:25:49,000 --> 00:25:51,280
THAN WE HAVE DONE IN THE AREAS 

576
00:25:51,280 --> 00:25:53,120
OF ALZHEIMER'S DISEASE RESEARCH 

577
00:25:53,120 --> 00:25:55,160
AND RECRUITING PEOPLE FROM 

578
00:25:55,160 --> 00:25:56,720
DIVERSE PARTS INTO STUDIES AND 

579
00:25:56,720 --> 00:26:01,240
RESOURCES SHOWN HERE AND 

580
00:26:01,240 --> 00:26:02,520
RECRUITMENT STRATEGY AND PRODUCT

581
00:26:02,520 --> 00:26:07,920
OF PUBLIC PRIVATE PARTNERSHIPS 

582
00:26:07,920 --> 00:26:09,360
AND SEARCHABLE DATABASE FOR 

583
00:26:09,360 --> 00:26:13,560
ENHANCING ENGAGE 

584
00:26:13,560 --> 00:26:18,880
THE AND OUTREACH THEME AND 

585
00:26:18,880 --> 00:26:20,320
CUSTOMIZABLE RECRUITMENT 

586
00:26:20,320 --> 00:26:21,680
RELEVANT NOT JUST IN ALZHEIMER'S

587
00:26:21,680 --> 00:26:24,280
OR NIA BUT RECRUITMENT IN 

588
00:26:24,280 --> 00:26:26,800
GENERAL WITH GREATER DIVERSITY.

589
00:26:26,800 --> 00:26:28,120
I'D LIKE TO TALK ABOUT WHAT'S 

590
00:26:28,120 --> 00:26:31,240
BEEN HAPPENING IN THE PAST AND 

591
00:26:31,240 --> 00:26:34,840
CURRENT AND COLLABORATIONS 

592
00:26:34,840 --> 00:26:36,720
BETWEEN OUR TWO INSTITUTES AND 

593
00:26:36,720 --> 00:26:38,960
THERE'S MULTIPLE.

594
00:26:38,960 --> 00:26:42,080
FOR EXAMPLE, IN 2013, THERE WAS 

595
00:26:42,080 --> 00:26:44,760
A JOINTLY SPONSORED WORKSHOP ON 

596
00:26:44,760 --> 00:26:46,800
CENTRAL MECHANISMS MUCH AGE AND 

597
00:26:46,800 --> 00:26:49,960
HEARING LOSS THAT LED TO AN RFA 

598
00:26:49,960 --> 00:26:51,880
IN 2018.

599
00:26:51,880 --> 00:26:54,000
THERE WERE FOUR AWARDS FUNDED.

600
00:26:54,000 --> 00:27:00,440
TWO FROM NIA AND TWO NIDCD AND 

601
00:27:00,440 --> 00:27:04,680
IT'S ONE IMPORTANT AREA OF THE 

602
00:27:04,680 --> 00:27:05,400
JOINT INTEREST.

603
00:27:05,400 --> 00:27:08,960
NEXT SLIDE SIMILARLY FOR THE 

604
00:27:08,960 --> 00:27:10,920
VESTIBULAR SYSTEM IMBALANCE IN 

605
00:27:10,920 --> 00:27:13,360
2019 OUR TWO INSTITUTES 

606
00:27:13,360 --> 00:27:14,520
SPONSORED A JOINT WORKSHOP WITH 

607
00:27:14,520 --> 00:27:16,480
THE OUTCOMES REPORTED IN THE 

608
00:27:16,480 --> 00:27:18,000
PUBLICATION NOTED HERE.

609
00:27:18,000 --> 00:27:19,840
AND THE NEXT SLIDE AGAIN LEADING

610
00:27:19,840 --> 00:27:22,440
TO AN RFA THAT WAS JOINTLY 

611
00:27:22,440 --> 00:27:25,720
FUNDED AND YOU CAN SEE HERE 

612
00:27:25,720 --> 00:27:28,400
HIGHLY SUCCESSFUL FUNDED 

613
00:27:28,400 --> 00:27:32,200
APPLICATIONS BY NIA AND ONE BY 

614
00:27:32,200 --> 00:27:33,560
NIDCD TO CONTINUE THROUGH THE 

615
00:27:33,560 --> 00:27:35,000
CURRENT TAKING ADVANTAGE OF OUR 

616
00:27:35,000 --> 00:27:37,720
JOINT INTEREST IN LOOKING FOR 

617
00:27:37,720 --> 00:27:38,360
OPPORTUNITIES TO JOINTLY SPONSOR

618
00:27:38,360 --> 00:27:48,360
RESEARCH.

619
00:27:48,360 --> 00:27:50,080
THE ICELANDIC STUDY STARTED WITH

620
00:27:50,080 --> 00:27:53,320
ONE NIA HAS BEEN SUPPORTING FOR 

621
00:27:53,320 --> 00:27:54,760
YEARS.

622
00:27:54,760 --> 00:27:56,200
BECAUSE OF THE EXTENSIVE RECORD 

623
00:27:56,200 --> 00:27:59,760
KEEPING IN ICELAND, IT'S AN 

624
00:27:59,760 --> 00:28:00,880
ENORMOUS INFRASTRUCTURE FOR 

625
00:28:00,880 --> 00:28:06,280
LONGITUDINAL STUDIES AND NIDCD 

626
00:28:06,280 --> 00:28:07,840
PARTICIPATED BY ADDING MEASURES 

627
00:28:07,840 --> 00:28:09,560
TO THE STUDIES COMBINED WITH 

628
00:28:09,560 --> 00:28:11,960
MULTIPLE DIMENSIONS AND A REAL 

629
00:28:11,960 --> 00:28:16,040
RICHNESS OF DATA AND AUGMENTS 

630
00:28:16,040 --> 00:28:17,120
THE STUDY ITSELF AS WELL AS 

631
00:28:17,120 --> 00:28:18,080
INFORMING AREAS OF INTEREST TO 

632
00:28:18,080 --> 00:28:23,160
NIDCD.

633
00:28:23,160 --> 00:28:25,880
SOME OUTCOMES FROM THAT STUDY 

634
00:28:25,880 --> 00:28:28,560
HAD THE MOST EFFECTIVE FACTORS 

635
00:28:28,560 --> 00:28:30,560
FOR HEARING LOSS THERE AND WAS 

636
00:28:30,560 --> 00:28:34,920
SOME GWAS IN THIS COUNTRY THAT 

637
00:28:34,920 --> 00:28:36,200
POINTED TO GENES OF POTENTIAL 

638
00:28:36,200 --> 00:28:38,880
INTEREST WITH HAIR LOSS AS ONE 

639
00:28:38,880 --> 00:28:51,320
OF THE GENE ASSOCIATION SHOWN.

640
00:28:51,320 --> 00:28:53,480
CELL STUDIES WITH PARTICIPATION 

641
00:28:53,480 --> 00:28:56,360
COLLABORATIVE IN SOME CASES 

642
00:28:56,360 --> 00:28:58,360
NOTED IF YOU LOOK AT THE RISK 

643
00:28:58,360 --> 00:29:00,720
FACTORS FOR DECREASE IN PHYSICAL

644
00:29:00,720 --> 00:29:02,440
ACTIVITY WITH TIME OVER AGE IT 

645
00:29:02,440 --> 00:29:04,840
COULD BE NOTED HEARING LOSS IS 

646
00:29:04,840 --> 00:29:05,680
SUBSTANTIAL.

647
00:29:05,680 --> 00:29:08,000
THE FIGURE TO THE LEFT SHOWS 

648
00:29:08,000 --> 00:29:13,800
OVER TIME OF DAY THE AMOUNT OF 

649
00:29:13,800 --> 00:29:24,360
PHYSICAL ACTIVITY IS AND IF YOU 

650
00:29:24,360 --> 00:29:26,880
LOOK RELATIVE TO THE INDIVIDUALS

651
00:29:26,880 --> 00:29:28,160
WITH NO HEARING LOSS AND 

652
00:29:28,160 --> 00:29:31,160
PROGRESSIVE INCREASES IN 

653
00:29:31,160 --> 00:29:32,560
DECREASING PHYSICAL ACTIVITY 

654
00:29:32,560 --> 00:29:33,360
OVER TIME OVER AGE AS ADULTS 

655
00:29:33,360 --> 00:29:40,360
AGE.

656
00:29:40,360 --> 00:29:42,800
VISION AND HEARING IMPAIRMENT 

657
00:29:42,800 --> 00:29:44,680
HAVE BEEN INCREASED WITH 

658
00:29:44,680 --> 00:29:45,960
LONELILINESS AND AS WE LOOK AT 

659
00:29:45,960 --> 00:29:49,480
THE RISK FACTORS FOR THESE 

660
00:29:49,480 --> 00:29:51,480
ATTRIBUTES IN THE QUALITY OF 

661
00:29:51,480 --> 00:29:54,000
LIFE IN OLDER ADULTS.

662
00:29:54,000 --> 00:29:56,440
AS WE LOOK AT COGNITIVE CHANGE 

663
00:29:56,440 --> 00:29:58,680
AND RELATIONSHIP TO DEMENTIA 

664
00:29:58,680 --> 00:29:59,680
ILLUSTRATED HERE AGAIN HEARING 

665
00:29:59,680 --> 00:30:01,280
LOSS IS ASSOCIATED WITH POOR 

666
00:30:01,280 --> 00:30:03,120
PERFORMANCE AND MEMORY TEST IN 

667
00:30:03,120 --> 00:30:06,240
PARTICULAR AND NOTABLE NOT 

668
00:30:06,240 --> 00:30:07,720
COMPLETELY UNDERSTOOD YET THOSE 

669
00:30:07,720 --> 00:30:09,520
WITH HIGH GLUCOSE LEVELS OR 

670
00:30:09,520 --> 00:30:13,040
THOSE IN WHOM THERE WAS A STRONG

671
00:30:13,040 --> 00:30:15,320
ASSOCIATION WITH WORSE COGNITIVE

672
00:30:15,320 --> 00:30:18,320
FUNCTION AMONG ONLY THOSE WITH 

673
00:30:18,320 --> 00:30:21,200
HEARING LOSS SUGGESTING HEARING 

674
00:30:21,200 --> 00:30:23,160
IMPAIRMENT INCREASES WITH 

675
00:30:23,160 --> 00:30:27,560
INDIVIDUALS WITH HIGH GLUCOSE ON

676
00:30:27,560 --> 00:30:28,480
PERFORMING AND LEARNING AND 

677
00:30:28,480 --> 00:30:30,520
THESE ARE THE KINDS OF STUDIES 

678
00:30:30,520 --> 00:30:31,960
WITH INCLUSION OF THESE KINDS OF

679
00:30:31,960 --> 00:30:33,920
FUNCTIONAL DIMENSIONS IN THE 

680
00:30:33,920 --> 00:30:34,560
LARGER LONGITUDINAL STUDIES IS 

681
00:30:34,560 --> 00:30:42,840
GOING TO BE CRITICAL.

682
00:30:42,840 --> 00:30:44,560
AROUND THE THEME OF DEMENTIA IF 

683
00:30:44,560 --> 00:30:46,080
YOU FOLLOW INDIVIDUALS 

684
00:30:46,080 --> 00:30:46,960
LONGITUDINAL OVER TIME AND OVER 

685
00:30:46,960 --> 00:30:50,080
THE YEARS LOOK AT THE DECREASE 

686
00:30:50,080 --> 00:30:52,240
IN COGNITIVE FUNCTION, THOSE WHO

687
00:30:52,240 --> 00:30:55,760
HAVE GOOD MIDDLE OR POOR 

688
00:30:55,760 --> 00:30:58,160
MULTI-SENSORY FUNCTION, SO THIS 

689
00:30:58,160 --> 00:31:00,240
IS CHARACTERIZED BY 

690
00:31:00,240 --> 00:31:02,000
MULTI-SENSORY IMPAIRMENT SHOW 

691
00:31:02,000 --> 00:31:02,960
PROGRESSIVE DECREASE IN FUNCTION

692
00:31:02,960 --> 00:31:04,560
GREATER THAN THOSE WITH 

693
00:31:04,560 --> 00:31:04,840
IMPAIRMENT.

694
00:31:04,840 --> 00:31:06,400
THOSE WHO WERE CALLED POOR IN 

695
00:31:06,400 --> 00:31:08,360
TERMS OF THEIR MULTI-SENSORY 

696
00:31:08,360 --> 00:31:11,800
FUNCTION, THERE WAS A TWOFOLD 

697
00:31:11,800 --> 00:31:13,080
GREATER DECREASE IN COGNITIVE 

698
00:31:13,080 --> 00:31:18,720
FUNCTION AND FOR THOSE EVEN WITH

699
00:31:18,720 --> 00:31:25,120
THE INTERMEDIATE SCORES RISK OF 

700
00:31:25,120 --> 00:31:30,560
DEMENTIA.

701
00:31:30,560 --> 00:31:31,960
ANOTHER INTERESTING ONE POINTS 

702
00:31:31,960 --> 00:31:33,680
TO THE POTENTIAL FOR A 

703
00:31:33,680 --> 00:31:34,840
DIFFERENCE AND AMONG INDIVIDUALS

704
00:31:34,840 --> 00:31:37,560
WITH DEMENTIA ONE OF THE 

705
00:31:37,560 --> 00:31:39,600
GREATEST PROBLEMS AND LEADS TO 

706
00:31:39,600 --> 00:31:41,800
THE INSTITUTIONALIZATION AND 

707
00:31:41,800 --> 00:31:44,400
INABILITY TO STAY AT HOME ARE 

708
00:31:44,400 --> 00:31:46,040
IMPAIRMENT AND IT'S ILLUSTRATED 

709
00:31:46,040 --> 00:31:48,720
HERE IN THE FIGURE IS AS YOU 

710
00:31:48,720 --> 00:31:49,800
MOVE TOWARDS GREATER HEARING 

711
00:31:49,800 --> 00:31:53,080
LOSS FROM LEFT TO RIGHT, THE 

712
00:31:53,080 --> 00:31:54,920
NUMBER OF NEURO PSYCHIATRIC 

713
00:31:54,920 --> 00:31:58,760
SYMPTOMS INCREASES AND NOTABLY 

714
00:31:58,760 --> 00:32:02,160
SHIFTED UP FOR THOSE NOT HEARING

715
00:32:02,160 --> 00:32:04,160
AID USERS VERSUS THOSE USING A 

716
00:32:04,160 --> 00:32:07,000
HEARING AID AND THERE'S AN 

717
00:32:07,000 --> 00:32:09,400
ASSOCIATION WITH USE OF HEARING 

718
00:32:09,400 --> 00:32:13,240
AIDS AND FEWER NEURO PSYCHIATRIC

719
00:32:13,240 --> 00:32:14,960
IMPAIRMENT AND DEMENTIA.

720
00:32:14,960 --> 00:32:18,360
THIS IS LEADING TO STUDIES AND 

721
00:32:18,360 --> 00:32:21,480
THOSE COLLABORATING IN THE 

722
00:32:21,480 --> 00:32:23,320
RANDOMIZED CONTROL STUDIES TO 

723
00:32:23,320 --> 00:32:25,200
LOOK AT DEMONSTRATION OF 

724
00:32:25,200 --> 00:32:26,920
CAUSALITY AND INTERVENTION THAT 

725
00:32:26,920 --> 00:32:30,160
CAN MAKE A GREAT DIFFERENCE IN 

726
00:32:30,160 --> 00:32:32,400
QUALITY OF LIFE FOR OLDER 

727
00:32:32,400 --> 00:32:32,640
ADULTS.

728
00:32:32,640 --> 00:32:34,760
I'LL CLOSE WITH A SERIES OF 

729
00:32:34,760 --> 00:32:38,360
LINKS TO WHAT GOES ON AT NIA 

730
00:32:38,360 --> 00:32:43,560
INCLUDING A BLOG WHERE IF YOU 

731
00:32:43,560 --> 00:32:49,720
WANT TO SCRIBE WE'D INVITE A 

732
00:32:49,720 --> 00:32:54,080
GUEST PRESENTATION FROM NIDCD.

733
00:32:54,080 --> 00:32:56,200
SO LET ME THANK YOU FOR A CHANCE

734
00:32:56,200 --> 00:32:58,240
TO REINFORCE AND FOR THE 

735
00:32:58,240 --> 00:32:59,240
COLLABORATION BETWEEN INSTITUTES

736
00:32:59,240 --> 00:33:00,600
AND HAVE A CONVERSATION WITH YOU

737
00:33:00,600 --> 00:33:01,440
ABOUT THAT.

738
00:33:01,440 --> 00:33:03,720
>> THANK YOU SO MUCH, RICHARD.

739
00:33:03,720 --> 00:33:08,280
THAT'S SO INTERESTING.

740
00:33:08,280 --> 00:33:09,880
I LEARN SOMETHING EVERY TIME I 

741
00:33:09,880 --> 00:33:12,120
TALK TO YOU SO I DIDN'T EVEN 

742
00:33:12,120 --> 00:33:13,280
KNOW ABOUT THE EARLY EFFORTS 

743
00:33:13,280 --> 00:33:14,360
THAT PREDATED ME.

744
00:33:14,360 --> 00:33:17,120
BEFORE WE OPEN THIS UP FOR 

745
00:33:17,120 --> 00:33:21,080
QUESTIONS, ASK DR. AMY PAREMBA 

746
00:33:21,080 --> 00:33:23,200
THE PROGRAM OFFICER TO SAY WORDS

747
00:33:23,200 --> 00:33:26,320
ABOUT AN UPCOMING WEBINAR THAT'S

748
00:33:26,320 --> 00:33:28,880
RELATED TO OUR COLLABORATION 

749
00:33:28,880 --> 00:33:35,480
BETWEEN INSTITUTES.

750
00:33:35,480 --> 00:33:35,920
>> THANK YOU.

751
00:33:35,920 --> 00:33:37,080
THANK YOU FOR THE WORK OVER THE 

752
00:33:37,080 --> 00:33:42,600
YEARS AND TO ALL THE PROGRAM 

753
00:33:42,600 --> 00:33:44,960
OFFICERS WE REGULAR COMMUNICATE 

754
00:33:44,960 --> 00:33:50,640
WITH AT THE NATIONAL INSTITUTE 

755
00:33:50,640 --> 00:33:52,280
OF AGING AND JOINT EFFORTS YOU 

756
00:33:52,280 --> 00:34:28,920
SEE UNDERWAY.

757
00:34:28,920 --> 00:34:32,160
WE HAVE DIRECT COSTS THAT WERE 

758
00:34:32,160 --> 00:34:33,520
ACCEPTED AND OVER THE SIX YEARS 

759
00:34:33,520 --> 00:34:35,520
AS DR. HODES SHOWED ON THE SLIDE

760
00:34:35,520 --> 00:34:37,960
IF YOU ADD THAT UP FOR 

761
00:34:37,960 --> 00:34:39,840
ALZHEIMER'S DISEASE RELATED 

762
00:34:39,840 --> 00:34:41,480
GRANTS AND SUPPLEMENTS IT'S 

763
00:34:41,480 --> 00:34:51,160
ABOUT $32 MILLION.

764
00:34:51,160 --> 00:34:52,320
WE'RE EXCITED WITH THE 

765
00:34:52,320 --> 00:34:54,000
SUPPLEMENTS AWARD AND FOUND 

766
00:34:54,000 --> 00:34:55,720
THERE'S INTERESTING OUTCOMES 

767
00:34:55,720 --> 00:34:58,520
THAT ARE ON THEIR WAY OR ALREADY

768
00:34:58,520 --> 00:35:00,320
BEING PUBLISHED AND GRANTS BEING

769
00:35:00,320 --> 00:35:08,760
GENERATED.

770
00:35:08,760 --> 00:35:10,080
WE WERE EXCITED TO INFORM THE 

771
00:35:10,080 --> 00:35:12,200
COMMUNITY AND SHARE THE RESULTS 

772
00:35:12,200 --> 00:35:14,440
AND PERHAPS FORM MORE 

773
00:35:14,440 --> 00:35:15,880
COLLABORATIONS AND FOR US TO 

774
00:35:15,880 --> 00:35:17,280
INTERACT TO SEE IF THERE'S OTHER

775
00:35:17,280 --> 00:35:17,960
WAYS TO SUPPORT THIS TYPE OF 

776
00:35:17,960 --> 00:35:23,360
RESEARCH.

777
00:35:23,360 --> 00:35:27,960
IN APRIL WE'LL HOLD A WEBINAR 

778
00:35:27,960 --> 00:35:29,760
CALLED SHARING OUR SCIENCE ON 

779
00:35:29,760 --> 00:35:32,280
ALZHEIMER'S DISEASE AND RELATED 

780
00:35:32,280 --> 00:35:34,360
DEMENTIAS AND BROADCASTING IT 

781
00:35:34,360 --> 00:35:37,240
LIVE TO THE PUBLIC AND MORE 

782
00:35:37,240 --> 00:35:39,720
UPCOMING IN THE NEWSLETTER.

783
00:35:39,720 --> 00:35:40,800
THERE'LL BE SCIENCE 

784
00:35:40,800 --> 00:35:41,760
PRESENTATIONS AND PANEL 

785
00:35:41,760 --> 00:35:46,840
DISCUSSION AND A DISCUSSION AT 

786
00:35:46,840 --> 00:35:51,360
LARGE ABOUT HOI TO BETTER 

787
00:35:51,360 --> 00:35:52,000
SUPPORT THE AREA.

788
00:35:52,000 --> 00:35:53,400
-- HOW TO BETTER SUPPORT THE 

789
00:35:53,400 --> 00:35:54,000
AREA.

790
00:35:54,000 --> 00:35:54,280
THANK YOU.

791
00:35:54,280 --> 00:35:56,320
>> NOW I'LL OPEN IT UP FOR 

792
00:35:56,320 --> 00:36:01,120
DISCUSSION AND QUESTIONS.

793
00:36:01,120 --> 00:36:02,680
I'LL WELCOME COUNCIL MEMBERS TO 

794
00:36:02,680 --> 00:36:03,320
ASK QUESTIONS OR START A 

795
00:36:03,320 --> 00:36:16,560
DISCUSSION.

796
00:36:16,560 --> 00:36:18,160
>> WHILE WE'RE WAITING I'D LIKE 

797
00:36:18,160 --> 00:36:19,320
TO THANK AMY FOR THE 

798
00:36:19,320 --> 00:36:20,280
PRESENTATION AND THE SLIDE 

799
00:36:20,280 --> 00:36:21,560
SHOWING A NUMBER OF PROGRAM 

800
00:36:21,560 --> 00:36:24,400
OFFICERS AT NIA INVOLVED.

801
00:36:24,400 --> 00:36:26,280
IT'S ILLUSTRATIVE OF WHAT WE'VE 

802
00:36:26,280 --> 00:36:28,960
BEEN DISCUSSING AND THE BREADTH 

803
00:36:28,960 --> 00:36:31,760
OF INTEREST FROM CLINICAL 

804
00:36:31,760 --> 00:36:33,360
GERIATRICS AND NEURAL SCIENCE 

805
00:36:33,360 --> 00:36:34,520
AND BEHAVIORAL RESEARCH SPANNING

806
00:36:34,520 --> 00:36:35,840
THE SPECTRUM OF WHAT WE DO AND 

807
00:36:35,840 --> 00:36:37,680
GREAT TO SEE WE'LL HAVE A CHANCE

808
00:36:37,680 --> 00:36:39,000
TO BRING YOUR GRANTEES TOGETHER 

809
00:36:39,000 --> 00:36:40,520
AS YOU NOTE IN THE WEBINAR.

810
00:36:40,520 --> 00:36:51,440
THANKS FOR ALL THAT INFORMATION.

811
00:36:51,440 --> 00:36:56,880
>> I REALLY APPRECIATE THE 

812
00:36:56,880 --> 00:37:00,120
COLLABORATION AT NIA FOR SEVERAL

813
00:37:00,120 --> 00:37:05,400
YEARS AND I'VE EXPERIENCED IT 

814
00:37:05,400 --> 00:37:15,160
PERSONALLY WITH DR.  CLAIR FOR 

815
00:37:15,160 --> 00:37:15,920
EXTENDING THE REALM AND I KNOW 

816
00:37:15,920 --> 00:37:17,880
SEVERAL OF OUR MEMBERS HAVE 

817
00:37:17,880 --> 00:37:22,280
TAKEN ADVANTAGE OF THAT.

818
00:37:22,280 --> 00:37:24,320
I THINK IT'S AN EXCELLENT 

819
00:37:24,320 --> 00:37:25,600
MECHANISM FOLKS ARE WORKING ON 

820
00:37:25,600 --> 00:37:37,400
SO THANK YOU FROM THE FIELD.

821
00:37:37,400 --> 00:37:39,160
>> ANY OTHER COMMENTS OR 

822
00:37:39,160 --> 00:37:39,680
QUESTIONS?

823
00:37:39,680 --> 00:37:44,480
RICHARD, I THINK YOU PROVIDED SO

824
00:37:44,480 --> 00:37:46,960
MUCH FOOD FOR THOUGHT I'M SO 

825
00:37:46,960 --> 00:37:49,200
ENTHUSIASTIC ABOUT OUR CONTINUED

826
00:37:49,200 --> 00:37:50,600
COLLABORATION WITH YOUR 

827
00:37:50,600 --> 00:37:50,880
INSTITUTE.

828
00:37:50,880 --> 00:37:54,760
I CAN'T TELL YOU HOW 

829
00:37:54,760 --> 00:37:55,400
APPRECIATIVE WE ARE OF ALL YOU 

830
00:37:55,400 --> 00:38:08,320
DO WITH US.

831
00:38:08,320 --> 00:38:08,440
 

832
00:38:08,440 --> 00:38:09,840
>> THANK YOU FOR THE 

833
00:38:09,840 --> 00:38:11,120
PRESENTATION AND APPRECIATE OF 

834
00:38:11,120 --> 00:38:12,960
THE INITIATIVES AND IN 

835
00:38:12,960 --> 00:38:15,760
COLLABORATION AND I DID GET A 

836
00:38:15,760 --> 00:38:17,480
SUPPLEMENT TO EXTEND OUR WORK TO

837
00:38:17,480 --> 00:38:21,200
ALZHEIMER'S DISEASE AND I THINK 

838
00:38:21,200 --> 00:38:22,920
THAT'S BEEN SOMETHING WE 

839
00:38:22,920 --> 00:38:24,160
WOULDN'T HAVE DONE OTHERWISE.

840
00:38:24,160 --> 00:38:29,720
I REALLY APPRECIATE THAT AND I 

841
00:38:29,720 --> 00:38:31,720
HAVE ONE QUESTION FOUR AND THAT 

842
00:38:31,720 --> 00:38:35,320
IS CAN YOU ESTIMATE WHEN, IF 

843
00:38:35,320 --> 00:38:40,320
EVER, WE WILL HAVE A TRULY 

844
00:38:40,320 --> 00:38:42,400
EFFECTIVE DISEASE MODIFYING 

845
00:38:42,400 --> 00:38:43,120
MEDICATION FOR ANY OF THE 

846
00:38:43,120 --> 00:39:03,560
DEMENTIAS?

847
00:39:03,560 --> 00:39:05,320
>> A HUGE QUESTION.

848
00:39:05,320 --> 00:39:08,920
IN TERMS OF MODIFICATION OR 

849
00:39:08,920 --> 00:39:15,680
SLOWING OR REVERSESAL THERE'S
ONE 

850
00:39:15,680 --> 00:39:17,720
DRUG NOW BEING STUDIED OR 

851
00:39:17,720 --> 00:39:19,760
CONSIDERED FOR CMS FOR COVERAGE 

852
00:39:19,760 --> 00:39:20,800
AND IT'S AN EXAMPLE OF THE 

853
00:39:20,800 --> 00:39:21,480
CHALLENGES WE FACE.

854
00:39:21,480 --> 00:39:23,080
AS WE LEARNED SO MUCH IN THE 

855
00:39:23,080 --> 00:39:24,760
BASIC SCIENCE AND INCREASED THE 

856
00:39:24,760 --> 00:39:28,320
NUMBER OF CLINICAL TRIALS AND 

857
00:39:28,320 --> 00:39:30,160
TARGETS, WHAT HAUNTS ALL OF US 

858
00:39:30,160 --> 00:39:32,000
IS WE STILL HAVE NOT REACHED 

859
00:39:32,000 --> 00:39:34,440
THAT POINT OF HAVING YET 

860
00:39:34,440 --> 00:39:35,720
EFFECTIVE INTERVENTION THE KINDS

861
00:39:35,720 --> 00:39:36,400
YOU DESCRIBE.

862
00:39:36,400 --> 00:39:40,080
WHAT I THINK HAS BECOME CLEAR 

863
00:39:40,080 --> 00:39:41,560
OVER THE SPECTRUM OF DEMENTIAS 

864
00:39:41,560 --> 00:39:44,720
EVEN THOSE CALLED ALZHEIMER'S 

865
00:39:44,720 --> 00:39:47,080
DISEASE BY PLAQUE PATHOLOGIES 

866
00:39:47,080 --> 00:39:48,920
ACROSS INDIVIDUALS IF YOU LOOK 

867
00:39:48,920 --> 00:39:50,640
AT BRAINS THERE'S A HUGE 

868
00:39:50,640 --> 00:39:54,760
CONTRIBUTION IN VARIOUS 

869
00:39:54,760 --> 00:39:56,160
PATHOLOGY ONE IS IT'S UNLIKELY 

870
00:39:56,160 --> 00:39:57,880
THERE'LL BE A SINGLE 

871
00:39:57,880 --> 00:39:59,440
INTERVENTION AFFECTING ALL OF 

872
00:39:59,440 --> 00:40:02,240
THEM AND TAILORED WITH 

873
00:40:02,240 --> 00:40:02,960
INTERVENTIONS THAT ARE 

874
00:40:02,960 --> 00:40:03,400
NECESSARY.

875
00:40:03,400 --> 00:40:07,240
IN TERMS OF WHERE WE STAND IN 

876
00:40:07,240 --> 00:40:08,960
HAVING SOMETHING THAT NEEDS THE 

877
00:40:08,960 --> 00:40:12,360
STANDARD, WE NOW HAVE A NUMBER 

878
00:40:12,360 --> 00:40:14,600
OF CLINICAL TRIALS INCLUDING 

879
00:40:14,600 --> 00:40:17,440
THOSE TARGETING AMYLOID AND RISK

880
00:40:17,440 --> 00:40:19,360
FACTORS THAT INCLUDE DIET, 

881
00:40:19,360 --> 00:40:20,160
EXERCISE AND COGNITIVE TRAINING 

882
00:40:20,160 --> 00:40:21,720
WHICH OVER THE NEXT THREE AND 

883
00:40:21,720 --> 00:40:23,760
FOUR YEARS HAVE THE POTENTIAL 

884
00:40:23,760 --> 00:40:26,560
AND OUR POWER TO IDENTIFY 

885
00:40:26,560 --> 00:40:30,960
SIGNIFICANT IMPACT IF INDEED 

886
00:40:30,960 --> 00:40:32,240
THEY ARE SUCCESSFUL.

887
00:40:32,240 --> 00:40:35,680
WE WANT IT KNOW HOW EFFECTIVE 

888
00:40:35,680 --> 00:40:40,520
THIS WILL BE UNTIL FURTHER DOWN 

889
00:40:40,520 --> 00:40:55,440
THE PIPELINE AND WAYS OF MACHINE

890
00:40:55,440 --> 00:40:58,560
LEARNING AND NETWORK AND THERE'S

891
00:40:58,560 --> 00:41:01,560
A COMBINATION OF HUGE ENTHUSIASM

892
00:41:01,560 --> 00:41:04,040
AND EXCITEMENT AND POTENTIAL 

893
00:41:04,040 --> 00:41:07,240
CONTRIBUTING TO THE FRUSTRATION 

894
00:41:07,240 --> 00:41:09,400
THAT RIGHT NOW WE DON'T HAVE THE

895
00:41:09,400 --> 00:41:11,680
KIND OF ANSWER YOU'D LIKE AND 

896
00:41:11,680 --> 00:41:12,640
HOW LONG IT WILL TAKE.

897
00:41:12,640 --> 00:41:16,040
I CAN SAY OUR INTERVENTIONS THAT

898
00:41:16,040 --> 00:41:18,760
ARE POWERED AND DIFFERENCES 

899
00:41:18,760 --> 00:41:19,920
PHARMACOLOGIC OVER THE NEXT TWO 

900
00:41:19,920 --> 00:41:21,360
AND THREE AND FOUR YEARS HAVE 

901
00:41:21,360 --> 00:41:24,760
THE POTENTIAL TO BE THE FIRST TO

902
00:41:24,760 --> 00:41:27,000
REALLY SHOW SIGNIFICANT AFFECTS 

903
00:41:27,000 --> 00:41:28,240
ON PROGRESSION OF SYMPTOMS OR 

904
00:41:28,240 --> 00:41:30,720
RISK OF IMPACT AN OF COURSE I 

905
00:41:30,720 --> 00:41:32,960
WISH THERE WERE MORE DEFINITIVE 

906
00:41:32,960 --> 00:41:33,560
ANSWERS.

907
00:41:33,560 --> 00:41:34,080
WE ALL DO.

908
00:41:34,080 --> 00:41:34,960
>> THANK YOU VERY MUCH.

909
00:41:34,960 --> 00:41:38,880
IT'S VERY HELPFUL.

910
00:41:38,880 --> 00:41:44,400
>> RUTH ANNE.

911
00:41:44,400 --> 00:41:47,360
>> THANK YOU FOR THE INTERESTING

912
00:41:47,360 --> 00:41:48,840
PRESENTATION AND AS OTHERS HAVE 

913
00:41:48,840 --> 00:41:51,960
SAID I'M APPRECIATIVE OF THE 

914
00:41:51,960 --> 00:41:55,080
COLLABORATION YOU HAVE WITH US 

915
00:41:55,080 --> 00:41:56,560
AND WITH OTHER INSTITUTES.

916
00:41:56,560 --> 00:41:57,920
ONE THING HIGHLIGHT FORD ME IN 

917
00:41:57,920 --> 00:42:00,280
YOUR TALK IS THE EXTENT AND I 

918
00:42:00,280 --> 00:42:02,760
THOUGHT ABOUT THIS OFF AND ON 

919
00:42:02,760 --> 00:42:06,560
JUST INCIDENTALLY BUT THE EXTENT

920
00:42:06,560 --> 00:42:09,960
TO WHICH DETERIORATION OF EACH 

921
00:42:09,960 --> 00:42:15,160
SENSE SEEMS TO BE A REASONABLE 

922
00:42:15,160 --> 00:42:22,600
FORECASTER OF EVENTUAL ACUTE  IT

923
00:42:22,600 --> 00:42:25,440
DEMENTIA AND WONDER IF NIA IS 

924
00:42:25,440 --> 00:42:26,480
BRINGING TOGETHER THE DIFFERENT 

925
00:42:26,480 --> 00:42:29,280
PARTIES AND STAKEHOLDERS TO 

926
00:42:29,280 --> 00:42:30,440
COMBINE EFFORTS AND LOOK FOR 

927
00:42:30,440 --> 00:42:33,960
GENERAL VERSUS SPECIFIC EFFECTS?

928
00:42:33,960 --> 00:42:35,920
>> I THINK THE ANSWER IS YES AND

929
00:42:35,920 --> 00:42:43,320
I THINK YOU SAW EXAMPLES OF IT 

930
00:42:43,320 --> 00:42:51,800
FOR ONE THE RAIKVIC STUDY AND 

931
00:42:51,800 --> 00:42:54,360
FOR CENTURY DEFICITS AND 

932
00:42:54,360 --> 00:42:58,760
HISTORICALLY IN FACT I'D SAY NIA

933
00:42:58,760 --> 00:43:00,680
HAS HAD RELATIVELY UNIQUE ROLE 

934
00:43:00,680 --> 00:43:02,600
IN THIS AREA.

935
00:43:02,600 --> 00:43:06,440
IT'S BEEN IN MULTI-SENSORY 

936
00:43:06,440 --> 00:43:10,560
DEFICITS WHERE IF NIDDK OR NEI 

937
00:43:10,560 --> 00:43:15,240
ARE FOCUSSING ON THE SENSORY 

938
00:43:15,240 --> 00:43:16,560
SYSTEMS THERE WAS A UNIQUE ROLE 

939
00:43:16,560 --> 00:43:19,080
AS THEY ALL CHANGE WITH AGING AS

940
00:43:19,080 --> 00:43:22,120
AN OPPORTUNITY TO THEREFORE 

941
00:43:22,120 --> 00:43:23,360
CATALYZE OR BE PART OF THE 

942
00:43:23,360 --> 00:43:24,360
COLLABORATION AND LOOK AT THE 

943
00:43:24,360 --> 00:43:31,240
IMPACT OF MULTI-SENSES.

944
00:43:31,240 --> 00:43:33,320
WHEN WE LOOKED AT LONELINESS OR 

945
00:43:33,320 --> 00:43:35,920
ISOLATION AS TWO FACTORS, THE 

946
00:43:35,920 --> 00:43:38,200
IMPACTS OF HEARING LOSS AND 

947
00:43:38,200 --> 00:43:43,560
VISION LOSS DIFFER ACROSS THOSE.

948
00:43:43,560 --> 00:43:46,760
SO THERE ARE INDIVIDUAL AND 

949
00:43:46,760 --> 00:43:50,000
OTHER EFFECTS WHEN YOU LOOK 

950
00:43:50,000 --> 00:43:51,840
ACROSS SENSES VERY MUCH NEEDED 

951
00:43:51,840 --> 00:43:56,240
AS YOU SUGGEST.

952
00:43:56,240 --> 00:43:59,200
>> I SEE THAT YOU'RE DEFINITELY 

953
00:43:59,200 --> 00:44:00,360
WORKING ACROSS INSTITUTES BUT 

954
00:44:00,360 --> 00:44:02,560
ARE THERE OTHER INVESTIGATORS AT

955
00:44:02,560 --> 00:44:08,160
THE BASE LEVEL WORK ACROSS 

956
00:44:08,160 --> 00:44:08,440
INSTITUTES.

957
00:44:08,440 --> 00:44:09,800
NOT JUST COMING TOGETHER WITH 

958
00:44:09,800 --> 00:44:10,160
THE RESULT.

959
00:44:10,160 --> 00:44:12,360
THERE'S A REAL VALUE IN HAVING 

960
00:44:12,360 --> 00:44:17,760
THE SAME INVESTIGATORS TRYING TO

961
00:44:17,760 --> 00:44:22,800
INVESTIGATE DIFFERENCES.

962
00:44:22,800 --> 00:44:26,680
>> WOE ISSUED A SOLICITATION FOR

963
00:44:26,680 --> 00:44:27,960
RESPONSES THAT DEALT WITH 

964
00:44:27,960 --> 00:44:29,480
MULTI-SENSORY EFFECTS WITH AGING

965
00:44:29,480 --> 00:44:32,760
AND IT WAS THE INTENT TO DO JUST

966
00:44:32,760 --> 00:44:34,960
AS YOU SAID BRINGING TOGETHER 

967
00:44:34,960 --> 00:44:37,120
INVESTIGATORS AND TEAMS LOOKING 

968
00:44:37,120 --> 00:44:38,560
AT MULTI-SENSORY SYSTEMS FOR 

969
00:44:38,560 --> 00:44:40,360
IMPACTS OF AGING.

970
00:44:40,360 --> 00:44:43,360
AS A SAID, SOME YEARS AGO THAT 

971
00:44:43,360 --> 00:44:45,920
INITIATIVE WAS LAST ACTIVE AND 

972
00:44:45,920 --> 00:44:48,000
PERHAPS WE OUGHT TO GET TOGETHER

973
00:44:48,000 --> 00:44:49,160
TO THINK ABOUT IT ONCE AGAIN.

974
00:44:49,160 --> 00:44:51,720
>> IT MAY BE A GOOD TIME.

975
00:44:51,720 --> 00:44:54,840
THERE'S MORE BASIC SCIENCE 

976
00:44:54,840 --> 00:44:55,120
INTEREST.

977
00:44:55,120 --> 00:45:02,640
THANK YOU VERY MUCH.

978
00:45:02,640 --> 00:45:05,080
>> I'M NOT SURE IF THIS IS 

979
00:45:05,080 --> 00:45:08,320
POSSIBLE BUT I GOT ONE OF THESE 

980
00:45:08,320 --> 00:45:12,000
SUPPLEMENTS AND APPRECIATE IT.

981
00:45:12,000 --> 00:45:15,000
IT WASN'T WONDERFUL WITH THE 

982
00:45:15,000 --> 00:45:16,080
PANDEMIC BUT IT SPARK A LOT OF 

983
00:45:16,080 --> 00:45:21,480
INTEREST IN OUR GROUP AND MANY 

984
00:45:21,480 --> 00:45:24,960
GROUPS AND THE NEXT STEP YOU'RE 

985
00:45:24,960 --> 00:45:28,640
GOING INTO AN AREA FOR US IN 

986
00:45:28,640 --> 00:45:30,760
CHEMO SENSORY GOING INTO AN AREA

987
00:45:30,760 --> 00:45:35,160
WHERE THAT'S NOT WHAT WE DO 

988
00:45:35,160 --> 00:45:36,960
EVERY DAY AND WE'RE IN 

989
00:45:36,960 --> 00:45:38,280
COMPETITION WITH PEOPLE DOING 

990
00:45:38,280 --> 00:45:39,800
THIS FOR YEARS OR DECADES AND 

991
00:45:39,800 --> 00:45:43,080
ALL THE DETAILS OF WHICH MODEL 

992
00:45:43,080 --> 00:45:48,440
TO CHOOSE AND SO ON IS A LITTLE 

993
00:45:48,440 --> 00:45:55,720
BIT CONCERNING HOW THE OLFACTORY

994
00:45:55,720 --> 00:45:58,280
SYSTEM AND TAO INTERACTS AND 

995
00:45:58,280 --> 00:46:00,000
WONDER IF THERE'S A WAY TO DO A 

996
00:46:00,000 --> 00:46:02,120
NEXT STAGE FROM THE SUPPLEMENTS 

997
00:46:02,120 --> 00:46:04,120
BUT NOT IN A WAY PROTECT US FROM

998
00:46:04,120 --> 00:46:06,360
HAVING TO HAVE THE WHOLE THING 

999
00:46:06,360 --> 00:46:07,800
AS AN EXPERT WHO SPENT DECADES 

1000
00:46:07,800 --> 00:46:10,360
OF THEIR LIFE DOING THIS.

1001
00:46:10,360 --> 00:46:12,360
SOME INTERMEDIATE BETWEEN THE 

1002
00:46:12,360 --> 00:46:19,160
SUPPLEMENTS AND A FULL-BLOWN 

1003
00:46:19,160 --> 00:46:19,360
RO1.

1004
00:46:19,360 --> 00:46:25,400
>> THANK YOU.

1005
00:46:25,400 --> 00:46:30,240
WE THOUGHT ABOUT THIS.

1006
00:46:30,240 --> 00:46:32,360
WHAT WE IDEALLY WOULD LIKE TO 

1007
00:46:32,360 --> 00:46:35,560
SEE IS THESE MAY ENTREE TO 

1008
00:46:35,560 --> 00:46:37,440
INDIVIDUALS BEING ABLE TO MOVE 

1009
00:46:37,440 --> 00:46:39,560
TO FULL PLEDGED APPLICATIONS 

1010
00:46:39,560 --> 00:46:40,560
RELEVANT TO ALZHEIMER'S DISEASE 

1011
00:46:40,560 --> 00:46:42,240
AND TAKE WHAT YOU SAID AS AN 

1012
00:46:42,240 --> 00:46:43,360
OUTSIDER IN THE FIELD THE 

1013
00:46:43,360 --> 00:46:45,800
QUESTION IS HOW CAN YOU BE BEST 

1014
00:46:45,800 --> 00:46:49,640
POSITIONED OR INFORMED OR 

1015
00:46:49,640 --> 00:46:53,600
PARTNERED IN ORDER TO MAKE THE 

1016
00:46:53,600 --> 00:46:57,280
MOST OF THAT AND A GREAT NUMBER 

1017
00:46:57,280 --> 00:47:02,040
OF OUR NEW GRANTEES ARE NEW TO 

1018
00:47:02,040 --> 00:47:05,120
THE FIELD AND MAYBE WE SHOULD 

1019
00:47:05,120 --> 00:47:06,840
THINK TO USE OUR PROGRAM 

1020
00:47:06,840 --> 00:47:10,080
OFFICERS TO HELP PARTNER 

1021
00:47:10,080 --> 00:47:11,360
INVESTIGATORS WITH THOSE IN THE 

1022
00:47:11,360 --> 00:47:13,080
FIELD OF ALZHEIMER'S RESEARCH TO

1023
00:47:13,080 --> 00:47:14,520
ADDRESS AS YOU'VE SEED WHETHER 

1024
00:47:14,520 --> 00:47:18,600
IT'S THE RIGHT MODELS IN ANIMAL 

1025
00:47:18,600 --> 00:47:21,600
MODEL DISEASE OR THE RIGHT 

1026
00:47:21,600 --> 00:47:23,880
BIOMARKERS TO USE IN STUDIES OF 

1027
00:47:23,880 --> 00:47:24,120
HUMANS.

1028
00:47:24,120 --> 00:47:25,320
I'LL TAKE YOUR COMMENTS AS A 

1029
00:47:25,320 --> 00:47:27,320
SIGN TO DO MORE THAN JUST 

1030
00:47:27,320 --> 00:47:28,320
ENCOURAGING PEOPLE TO FOLLOW-UP 

1031
00:47:28,320 --> 00:47:32,240
AND MAYBE SEE IF WE CAN INFORM 

1032
00:47:32,240 --> 00:47:35,560
MORE ORGANIZED CONSORTIUM OF OUR

1033
00:47:35,560 --> 00:47:37,160
PROGRAM OFFICERS TO HELP DIRECT 

1034
00:47:37,160 --> 00:47:39,560
THE KIND OF PROGRAMMATIC EFFORTS

1035
00:47:39,560 --> 00:47:41,960
I THINK YOU RIGHTLY STRESS WOULD

1036
00:47:41,960 --> 00:47:43,840
HELP US TRANSLATE THE INITIAL 

1037
00:47:43,840 --> 00:47:47,640
ENTREE INTO THE MOST PRODUCTIVE 

1038
00:47:47,640 --> 00:47:49,640
RESEARCH TRAJECTORIES.

1039
00:47:49,640 --> 00:47:52,360
>> GREAT IDEAS.

1040
00:47:52,360 --> 00:47:57,760
I THINK WE'RE HOPING THIS 

1041
00:47:57,760 --> 00:48:00,480
WEBINAR WE HAVE PLANNED FOR 

1042
00:48:00,480 --> 00:48:02,000
APRIL ARE THE BEGINNING OF NEW 

1043
00:48:02,000 --> 00:48:18,600
INITIATIVES TO WORK ON TOGETHER.

1044
00:48:18,600 --> 00:48:19,360
>> THANK YOU.

1045
00:48:19,360 --> 00:48:20,920
>> GREAT TO BE WITH YOU.

1046
00:48:20,920 --> 00:48:21,760
>> ALL RIGHT.

1047
00:48:21,760 --> 00:48:24,320
SO NEXT ON OUR PROGRAM I'M VERY 

1048
00:48:24,320 --> 00:48:27,880
EXCITED TO WELCOME OUR OWN 

1049
00:48:27,880 --> 00:48:32,160
DR. TOM FRIEDMAN ONE OF OUR 

1050
00:48:32,160 --> 00:48:34,560
INTRAMURAL SCIENTIST AND CHIEF 

1051
00:48:34,560 --> 00:48:37,600
OF THE LABORATORY OF MOLECULAR 

1052
00:48:37,600 --> 00:48:40,840
GENETICS IN OUR INTRAMURAL 

1053
00:48:40,840 --> 00:48:41,080
PROGRAM.

1054
00:48:41,080 --> 00:48:46,280
I ASKED TOM TO SHARE HIS 

1055
00:48:46,280 --> 00:48:47,560
EXCITING RESEARCH ON USHER 

1056
00:48:47,560 --> 00:48:48,360
SYNDROME AND NON-SYNDROME 

1057
00:48:48,360 --> 00:49:32,160
DEAFNESS.

1058
00:49:32,160 --> 00:49:36,320
>> I'M GOING TELL YOU A STORY 

1059
00:49:36,320 --> 00:49:38,680
THAT BEGAN IN BERLIN, GERMANY IN

1060
00:49:38,680 --> 00:49:42,960
1861.

1061
00:49:42,960 --> 00:49:45,760
AND THIS STORY REQUIRES SOME 

1062
00:49:45,760 --> 00:49:47,560
BACKGROUND INFORMATION THAT'S 

1063
00:49:47,560 --> 00:49:48,360
IMPORTANT TO UNDERSTAND THE 

1064
00:49:48,360 --> 00:49:52,360
PAPER THAT WAS RECENTLY 

1065
00:49:52,360 --> 00:50:02,720
PUBLISHED AND THAT DR. TUCCI 

1066
00:50:02,720 --> 00:50:04,440
ASKED ME TO PRESENT BETWEEN THE 

1067
00:50:04,440 --> 00:50:05,560
STAFF AND NIDDK AND PARTNERED 

1068
00:50:05,560 --> 00:50:07,120
WITH THE UNIVERSITY OF MARYLAND 

1069
00:50:07,120 --> 00:50:12,360
AND ITS TEAM LEADER ON THE STUDY

1070
00:50:12,360 --> 00:50:15,160
AND PROFESSORS ON THIS.

1071
00:50:15,160 --> 00:50:17,760
SO FIRST I'LL TELL YOU A LITTLE 

1072
00:50:17,760 --> 00:50:19,440
BIT ABOUT MY LAB.

1073
00:50:19,440 --> 00:50:23,040
MY LAB'S INVOLVED IN STUDYING 

1074
00:50:23,040 --> 00:50:25,560
HEREDITARY DEAFNESS AND DEAFNESS

1075
00:50:25,560 --> 00:50:28,240
SYNDROMES AND WE DO THIS BY 

1076
00:50:28,240 --> 00:50:30,960
ASCERTAINING FAMILIES ALL OVER 

1077
00:50:30,960 --> 00:50:32,040
THE WORLD.

1078
00:50:32,040 --> 00:50:35,600
AND WE ASCERTAINED FAMILIES IN 

1079
00:50:35,600 --> 00:50:38,560
BALI AND INDIA AND STILL FOR THE

1080
00:50:38,560 --> 00:50:40,720
LAST 20 YEARS HAVE BEEN 

1081
00:50:40,720 --> 00:50:43,960
ASCERTAINING FAMILIES IN 

1082
00:50:43,960 --> 00:50:46,240
PAKISTAN AND IN NORTH AMERICA 

1083
00:50:46,240 --> 00:50:52,600
AND MORE RECENTLY IN NIGERIA.

1084
00:50:52,600 --> 00:50:54,960
SO THIS IS A PAPER THAT WAS 

1085
00:50:54,960 --> 00:50:57,640
RECENTLY PUBLISHED ABOUT THE 

1086
00:50:57,640 --> 00:51:00,280
NIGERIAN STUDY ANDY GRIFFITH AND

1087
00:51:00,280 --> 00:51:04,560
I START ABOUT FOUR YEARS AGO 

1088
00:51:04,560 --> 00:51:09,280
WITH AN MD IN NIGERIA.

1089
00:51:09,280 --> 00:51:14,360
AND A STAFF SCIENTIST FROM NIDCD

1090
00:51:14,360 --> 00:51:19,760
BECAME THE SENIOR AUTHOR ON THE 

1091
00:51:19,760 --> 00:51:19,960
STUDY.

1092
00:51:19,960 --> 00:51:21,200
YOU CAN SEE FROM THIS SLIDE, 

1093
00:51:21,200 --> 00:51:25,040
THESE ARE LITTLE FAMILIES AND 

1094
00:51:25,040 --> 00:51:27,440
THEY'RE NONE CONSANGUINEOUS AND 

1095
00:51:27,440 --> 00:51:30,000
IT'S HARD TO FIGURE OUT WHAT THE

1096
00:51:30,000 --> 00:51:31,400
POSITIVE VARIANTS ARE.

1097
00:51:31,400 --> 00:51:33,440
SO STARTING WITH ABOUT 60 

1098
00:51:33,440 --> 00:51:36,720
FAMILIES BER ABLE TO IDENTIFY 

1099
00:51:36,720 --> 00:51:42,600
WHAT WE BELIEVED ARE THE LIKELY 

1100
00:51:42,600 --> 00:51:48,360
PATHOGENIC VARIANTS IN HALF THE 

1101
00:51:48,360 --> 00:51:50,960
FAMILIES AND YOU'LL SEE NOVEL 

1102
00:51:50,960 --> 00:51:53,120
VARIANTS IN PREVIOUSLY REPORTED 

1103
00:51:53,120 --> 00:51:55,040
DEAFNESS GENES.

1104
00:51:55,040 --> 00:52:00,120
AND THERE'S A LOT OF DIFFERENT 

1105
00:52:00,120 --> 00:52:00,600
GENES.

1106
00:52:00,600 --> 00:52:03,640
ONE MY FAVORITE GENE AND THESE 

1107
00:52:03,640 --> 00:52:05,160
ARE GENES REPORTED ASSOCIATED 

1108
00:52:05,160 --> 00:52:08,720
WITH DEAFNESS BUT IN THESE 

1109
00:52:08,720 --> 00:52:29,000
FAMILIES, WE FOUND VARIANTS.

1110
00:52:29,000 --> 00:52:32,320
SO WE LOOKED AT THESE CHILDHOOD 

1111
00:52:32,320 --> 00:52:34,800
DEAFNESS IN NIGERIA AND THAT 

1112
00:52:34,800 --> 00:52:36,720
WILL MAKE IT SOMEWHAT DIFFICULT 

1113
00:52:36,720 --> 00:52:39,920
AND EXPENSIVE TO DETERMINE A 

1114
00:52:39,920 --> 00:52:44,720
MOLECULAR DIAGNOSIS FOR THE 

1115
00:52:44,720 --> 00:52:48,280
HEARING LOSS IN YOUNG CHILDREN 

1116
00:52:48,280 --> 00:52:49,560
BECAUSE OF THE LARGE VARIETY OF 

1117
00:52:49,560 --> 00:52:50,560
GENES IDENTIFIED.

1118
00:52:50,560 --> 00:52:51,840
THAT'S GOING TO BE A REAL 

1119
00:52:51,840 --> 00:52:54,360
CHALLENGE AND I JUST WANT TO ADD

1120
00:52:54,360 --> 00:52:57,120
THAT PRESENTLY THERE'S A DATA 

1121
00:52:57,120 --> 00:52:59,360
DESERT ABOUT THE MUTATIONS AND 

1122
00:52:59,360 --> 00:53:02,360
GENES ASSOCIATED WITH DEAFNESS 

1123
00:53:02,360 --> 00:53:06,200
IN THE AFRICAN AMERICANS AND 

1124
00:53:06,200 --> 00:53:12,320
EXPECT IT WILL SIMILARLY HIGHLY 

1125
00:53:12,320 --> 00:53:18,360
HETEROGENEOUS.

1126
00:53:18,360 --> 00:53:20,400
AND WE'VE HAD THESE LARGE 

1127
00:53:20,400 --> 00:53:26,280
CONSANGUINEOUS FAMILIES IN WHICH

1128
00:53:26,280 --> 00:53:33,600
THE PARENTS ARE FIRST COUSINS 

1129
00:53:33,600 --> 00:53:36,360
AND BRING RECESSSIVE MUTATION 

1130
00:53:36,360 --> 00:53:38,080
AND MAKES IT DIFFICULT TO MAP 

1131
00:53:38,080 --> 00:53:42,080
THE GENE TO A CHROMOSOMAL LOCUS 

1132
00:53:42,080 --> 00:53:43,760
AND BY EXOME SEQUENCING MAKES IT

1133
00:53:43,760 --> 00:53:47,000
EASIER TO IDENTIFY THE MUTANT 

1134
00:53:47,000 --> 00:53:48,720
VARIANTS ASSOCIATED WITH THE 

1135
00:53:48,720 --> 00:53:50,960
DEAFNESS WHICH WE THEN STUDY AT 

1136
00:53:50,960 --> 00:53:53,800
VARIOUS LEVELS AS INDICATED ON 

1137
00:53:53,800 --> 00:53:56,400
THE LEFT SIDE AND GENERATE 

1138
00:53:56,400 --> 00:53:57,680
ANIMAL MODELS AND DISCOVER 

1139
00:53:57,680 --> 00:53:58,480
MOLECULAR PARTNERS AND THINK OF 

1140
00:53:58,480 --> 00:54:00,920
THERAPIES.

1141
00:54:00,920 --> 00:54:04,200
THESE ARE TWO ACTUAL FAMILIES 

1142
00:54:04,200 --> 00:54:06,360
THAT WERE ASCERTAINED ABOUT 20 

1143
00:54:06,360 --> 00:54:10,760
YEARS AGO AND THEY WERE PART OF 

1144
00:54:10,760 --> 00:54:15,440
THE STUDY DONE IN MY LAB WITH A 

1145
00:54:15,440 --> 00:54:19,400
POST-DOCTORAL FELLOW AND USED TO

1146
00:54:19,400 --> 00:54:23,560
MAP THE USHER SYNDROME TO A 

1147
00:54:23,560 --> 00:54:30,480
NOVEL LOCUS ON CHROMOSOME 10.

1148
00:54:30,480 --> 00:54:32,520
AND THAT LOCUS WAS CLOSE TO ONE 

1149
00:54:32,520 --> 00:54:35,560
ALSO IDENTIFIED ASSOCIATED WITH 

1150
00:54:35,560 --> 00:54:41,640
USHER SYNDROME WHICH WAS USHER 

1151
00:54:41,640 --> 00:54:46,920
1D AND THE GENE DFNB23 

1152
00:54:46,920 --> 00:54:52,160
IDENTIFIED BY A GROUP IN 

1153
00:54:52,160 --> 00:54:57,680
CLEVELAND.

1154
00:54:57,680 --> 00:54:58,560
WHAT'S MOST INTERESTING AND 

1155
00:54:58,560 --> 00:55:00,160
IMPORTANT IN THIS STUDY WAS 

1156
00:55:00,160 --> 00:55:05,920
THERE WERE VARIANTS OF THIS GENE

1157
00:55:05,920 --> 00:55:10,360
THAT IT CAUSED NOT JUST USHER 

1158
00:55:10,360 --> 00:55:12,320
SYNDROME BUT CAN CAUSE 

1159
00:55:12,320 --> 00:55:13,600
NON-SYNDROME OF DEAFNESS AND 

1160
00:55:13,600 --> 00:55:16,880
THERE'S A VARIANTS AND VARIANTS 

1161
00:55:16,880 --> 00:55:19,040
THAT CAUSE USHER SYNDROME AND 

1162
00:55:19,040 --> 00:55:22,560
THIS MEANS A PARTIALLY 

1163
00:55:22,560 --> 00:55:26,280
FUNCTIONING MUTANT PROTEIN IS 

1164
00:55:26,280 --> 00:55:27,680
SUFFICIENT TO PRESERVE VISION 

1165
00:55:27,680 --> 00:55:29,240
WHEN IT IS NOT SUFFICIENT TO 

1166
00:55:29,240 --> 00:55:32,200
AWHETHER YOU FOR NORMAL HEARING.

1167
00:55:32,200 --> 00:55:34,040
-- TO ALLOW FOR NORMAL HEARING.

1168
00:55:34,040 --> 00:55:36,160
THAT MEANS THERE'S REASON TO BE 

1169
00:55:36,160 --> 00:55:38,360
OPTIMISTIC YOU CAN DEVELOP A 

1170
00:55:38,360 --> 00:55:46,520
THERAPY WHEN EVEN A DEFECTIVE 

1171
00:55:46,520 --> 00:55:47,760
PROTEIN ARE SUFFICIENT TO 

1172
00:55:47,760 --> 00:55:51,440
PRESERVE VISION.

1173
00:55:51,440 --> 00:55:54,680
SO IT'S ONE OF NINE GENES THAT 

1174
00:55:54,680 --> 00:55:59,560
IS UNEQUIVOCALLY ASSOCIATED WITH

1175
00:55:59,560 --> 00:56:03,440
USHER SYNDROME AND THERE ARE 

1176
00:56:03,440 --> 00:56:04,800
SERIES OF OTHER GENES SUGGESTED 

1177
00:56:04,800 --> 00:56:08,320
TO BE ASSOCIATED WITH USHER 

1178
00:56:08,320 --> 00:56:14,600
SYNDROME.

1179
00:56:14,600 --> 00:56:18,760
AND IT'S HETEROGENEOUS AND ALSO 

1180
00:56:18,760 --> 00:56:22,160
CLINICALLY HETEROGENEOUS AND 

1181
00:56:22,160 --> 00:56:25,320
DIVIDE BY CLINICIANS AND A 

1182
00:56:25,320 --> 00:56:28,840
RECENT STUDY AT THE NIDCD INTO 

1183
00:56:28,840 --> 00:56:32,560
TYPE 1, 2 AND 3 AND ATYPICAL 

1184
00:56:32,560 --> 00:56:35,440
USHER SYNDROME INDIVIDUALS WHO 

1185
00:56:35,440 --> 00:56:38,680
DON'T FALL NEATLY INTO THE 

1186
00:56:38,680 --> 00:56:39,120
CATEGORIES.

1187
00:56:39,120 --> 00:56:40,400
AND TYPE 1 IS THE MOST SEVERE 

1188
00:56:40,400 --> 00:56:42,640
FORM OF USHER SYNDROME.

1189
00:56:42,640 --> 00:56:47,960
THE INDIVIDUALS HAVE CONGENITAL 

1190
00:56:47,960 --> 00:56:49,640
LATERAL PROFOUND DEAFNESS 

1191
00:56:49,640 --> 00:56:52,360
OPPOSED TO TYPE 2 AND 3 MODERATE

1192
00:56:52,360 --> 00:56:55,320
TO SEVERE OR PROGRESSIVE 

1193
00:56:55,320 --> 00:56:57,920
POST-LINGUAL AND THE VISION 

1194
00:56:57,920 --> 00:57:00,320
PHENOTYPE HAS AN EARLY ON SET OR

1195
00:57:00,320 --> 00:57:04,000
EARLIER ONSET THAN TYPE 2 AND 3 

1196
00:57:04,000 --> 00:57:08,560
AND CHARACTERIZED BY RETINITIS 

1197
00:57:08,560 --> 00:57:10,840
PIGMENTOSA LOSS OF THE RETINA 

1198
00:57:10,840 --> 00:57:13,120
PHOTO RECEPTORS AND RODS AND 

1199
00:57:13,120 --> 00:57:18,520
CONES AND BLOOD VESSEL 

1200
00:57:18,520 --> 00:57:25,560
ATTENUATION AND OPTIC DISC 

1201
00:57:25,560 --> 00:57:31,720
PALLOR AND A LOSS OF THE 

1202
00:57:31,720 --> 00:57:34,000
VESTIBULAR REFLEXES OPPOSED TO 

1203
00:57:34,000 --> 00:57:41,880
MORE TYPICAL RESPONSES IN TYPE 2

1204
00:57:41,880 --> 00:57:44,400
AND 3.

1205
00:57:44,400 --> 00:57:51,920
SO IN 1861 THERE WAS A PAPER 

1206
00:57:51,920 --> 00:57:56,760
PUBLISHED IN GERMANY AND IN 

1207
00:57:56,760 --> 00:57:58,360
ENGLISH IT'S DISSENT FROM 

1208
00:57:58,360 --> 00:57:59,920
MARRIAGES AS A REASON FOR 

1209
00:57:59,920 --> 00:58:13,120
RETINITIS PIGMENTOSA A JEWISH 

1210
00:58:13,120 --> 00:58:15,240
POPULATION IN BERLIN AND NOTICED

1211
00:58:15,240 --> 00:58:18,640
BY THIS AUTHOR THAT THERE WAS A 

1212
00:58:18,640 --> 00:58:23,920
CONCENTRATION OF USHER SYNDROME 

1213
00:58:23,920 --> 00:58:29,800
SEGREGATING THIS TYPE OF JEWISH 

1214
00:58:29,800 --> 00:58:40,600
POPULATION AND I SUGGESTED TO 

1215
00:58:40,600 --> 00:58:42,040
FIGURE OUT WHAT THE GENE OR 

1216
00:58:42,040 --> 00:58:46,560
GENES ARE THAT ARE INVOLVED IN 

1217
00:58:46,560 --> 00:58:58,120
USHER SYNDROME IN THE ASHKENAZI 

1218
00:58:58,120 --> 00:58:59,480
JEWISH POPULATION AND DID JUST 

1219
00:58:59,480 --> 00:59:00,360
THAT.

1220
00:59:00,360 --> 00:59:05,880
THE FIRST THING IS TO ASCERTAIN 

1221
00:59:05,880 --> 00:59:08,360
FAMILIES SEGREGATING USHER 

1222
00:59:08,360 --> 00:59:09,720
SYNDROME.

1223
00:59:09,720 --> 00:59:11,840
THERE ARE FOUR FAMILIES CLEARLY 

1224
00:59:11,840 --> 00:59:13,440
SEGREGATING THE SYNDROME 

1225
00:59:13,440 --> 00:59:20,240
FAMILIES 2, 3, 4 AND 5 AND 

1226
00:59:20,240 --> 00:59:22,800
THERE'S NON-SYNDROMIC DEAFNESS 

1227
00:59:22,800 --> 00:59:24,960
IN ANOTHER BRANCH AND THESE ARE 

1228
00:59:24,960 --> 00:59:26,080
TWO YOUNG CHILDREN IN THE THIRD 

1229
00:59:26,080 --> 00:59:28,520
GENERATION AND THE PARENTS WERE 

1230
00:59:28,520 --> 00:59:30,040
CONVINCE THE TWO YOUNG CHILDREN 

1231
00:59:30,040 --> 00:59:31,920
DID NOT HAVE WHAT THEIR 

1232
00:59:31,920 --> 00:59:34,440
RELATIVES HAVE WAS NON-SYNDROMIC

1233
00:59:34,440 --> 00:59:35,960
DEAFNESS.

1234
00:59:35,960 --> 00:59:41,160
HOWEVER, THEY ARE ALL 

1235
00:59:41,160 --> 00:59:47,200
SEGREGATING MUTATION, COMMON 

1236
00:59:47,200 --> 00:59:52,280
MUTATION IN THIS CODON THAT 

1237
00:59:52,280 --> 01:00:00,440
USUALLY CODES FOR ARGENINE AND 

1238
01:00:00,440 --> 01:00:05,000
THE MUTANT ALLELE WOULD TRUNCATE

1239
01:00:05,000 --> 01:00:07,960
A LARGE PROTEIN EARLY ON AND 

1240
01:00:07,960 --> 01:00:11,960
THERE'S PROBABLY NO PROTEIN MADE

1241
01:00:11,960 --> 01:00:20,480
AT ALL ESPECIALLY WHEN THEY'RE 

1242
01:00:20,480 --> 01:00:24,000
HOMOZYGOUS AND THE MOUSE PROTEIN

1243
01:00:24,000 --> 01:00:25,280
AND THE HUMAN ARE VERY VERY 

1244
01:00:25,280 --> 01:00:35,320
SIMILAR.

1245
01:00:35,320 --> 01:00:42,120
AND THE CARRIER FREQUENCY HAS A 

1246
01:00:42,120 --> 01:00:43,680
VARIATION IN FREQUENCY AND THESE

1247
01:00:43,680 --> 01:00:50,360
ARE INDIVIDUALS WITH ONE MUTANT 

1248
01:00:50,360 --> 01:00:50,880
ALL-LE

1249
01:00:50,880 --> 01:00:54,640
ALLELE AND ONE WILD TYPE BUT 

1250
01:00:54,640 --> 01:00:56,200
CARRYING THE VARIANT AND THAT'S 

1251
01:00:56,200 --> 01:00:58,920
A HIGH CARRIER FREQUENCY.

1252
01:00:58,920 --> 01:01:03,160
IT'S NOT FOUND IN OTHER JEWISH 

1253
01:01:03,160 --> 01:01:06,160
POPULATIONS.

1254
01:01:06,160 --> 01:01:08,960
SO HOW DO YOU END UP WITH A HIGH

1255
01:01:08,960 --> 01:01:13,240
FREQUENCY OF A PARTICULAR 

1256
01:01:13,240 --> 01:01:15,360
MUTATION A FOUNDER MUTATION?

1257
01:01:15,360 --> 01:01:18,960
A HIGH CARRIER RATE CAN RESULT 

1258
01:01:18,960 --> 01:01:21,600
FROM SELECTIVE ADVANTAGE OF THAT

1259
01:01:21,600 --> 01:01:23,200
MUTATION BUT YOU CAN'T ADVANTAGE

1260
01:01:23,200 --> 01:01:24,600
THERE'S A SELECT ADVANTAGE TO 

1261
01:01:24,600 --> 01:01:25,600
BEING DEAF AND LOSING YOUR 

1262
01:01:25,600 --> 01:01:34,240
VISION OR A HIGH MUTATION RATE I

1263
01:01:34,240 --> 01:01:36,640
DOUBT THAT OR A POPULATION 

1264
01:01:36,640 --> 01:01:38,800
BOTTLE NECK AND THERE'S BEEN 

1265
01:01:38,800 --> 01:01:40,560
MIGRATION AND GREAT LOSS OF LIFE

1266
01:01:40,560 --> 01:01:43,560
AND IN A SCIENTIFIC AMERICAN 

1267
01:01:43,560 --> 01:01:45,440
ARTICLE, MY FORMER COLLEAGUE 

1268
01:01:45,440 --> 01:01:47,840
HERE SAID AND I'LL QUOTE IT 

1269
01:01:47,840 --> 01:01:51,960
BECAUSE I LIKE THE PHRASE IN THE

1270
01:01:51,960 --> 01:01:54,120
PAPER, EVERYONE WITH A FOUNDER 

1271
01:01:54,120 --> 01:01:55,520
MUTATION HAS A COMMON ANCESTOR, 

1272
01:01:55,520 --> 01:01:57,320
THE FOUNDER, IN WHOM THE 

1273
01:01:57,320 --> 01:02:08,280
MUTATION FIRST APPEARED.

1274
01:02:08,280 --> 01:02:12,560
THAT'S NOT THE ONLY MUTATION 

1275
01:02:12,560 --> 01:02:14,800
THAT CAUSE THE FOUNDER TRAIT AND

1276
01:02:14,800 --> 01:02:18,960
MY LAB IDENTIFIED A VARIANT OF A

1277
01:02:18,960 --> 01:02:23,200
GENE CALLED GJB2 THAT ENCODES A 

1278
01:02:23,200 --> 01:02:24,200
GAP JUNCTION AND BASICALLY 

1279
01:02:24,200 --> 01:02:27,360
THAT'S A PORTAL BETWEEN TWO 

1280
01:02:27,360 --> 01:02:29,240
CELLS FOR SMALL MOLECULES.

1281
01:02:29,240 --> 01:02:31,840
SO SMALL MOLECULES CAN MOVE BACK

1282
01:02:31,840 --> 01:02:32,880
AND FORTH BETWEEN CELLS AND PASS

1283
01:02:32,880 --> 01:02:38,840
THROUGH THE GAP JUNCTIONS AND 

1284
01:02:38,840 --> 01:02:47,000
THE 167DELT AND THE CARRIER 

1285
01:02:47,000 --> 01:02:52,160
FREQUENCY IS EVEN HIGHER FOR 4% 

1286
01:02:52,160 --> 01:02:53,840
AND DIDN'T FIND IT IN ANY OTHER 

1287
01:02:53,840 --> 01:03:02,000
POPULATIONS WE STUDIED.

1288
01:03:02,000 --> 01:03:11,320
SO ANOTHER STUDY WAS TO FIND 

1289
01:03:11,320 --> 01:03:14,000
YOUNG CHILDREN UNDER AGE OF 10 

1290
01:03:14,000 --> 01:03:20,120
DIAGNOSED WITH NON-SYNDROMIC 

1291
01:03:20,120 --> 01:03:23,080
DEAFNESS AND ASSUMED TO BE 

1292
01:03:23,080 --> 01:03:25,520
NON-SYNDROMIC DEAFNESS.

1293
01:03:25,520 --> 01:03:28,760
WE IDENTIFIED 20 SUCH 

1294
01:03:28,760 --> 01:03:30,080
INDIVIDUALS, 20 CHILDREN LIKE 

1295
01:03:30,080 --> 01:03:35,520
THAT AND PREDICTED SOME WOULD BE

1296
01:03:35,520 --> 01:03:43,760
HOMO ZYGOUS AND 2 OF THE 20 WERE

1297
01:03:43,760 --> 01:03:45,240
AND WOULD LOSE THEIR VISION OVER

1298
01:03:45,240 --> 01:03:49,560
TIME.

1299
01:03:49,560 --> 01:03:51,320
THAT BRINGS ME TO A BRIEF 

1300
01:03:51,320 --> 01:03:53,560
DISCUSSION OF THIS PAPER THAT 

1301
01:03:53,560 --> 01:04:16,320
APPEARED IN NOVEMBER 2021.

1302
01:04:16,320 --> 01:04:23,240
AND IN OUR INSTITUTE THERE WAS A

1303
01:04:23,240 --> 01:04:26,240
POST-DOC IN MY LAB ANDY GRIFFITH

1304
01:04:26,240 --> 01:04:28,760
AND CARMEN BREWER AND MYSELF AND

1305
01:04:28,760 --> 01:04:35,160
AT THE UNIVERSITY OF MARYLAND 

1306
01:04:35,160 --> 01:04:54,440
THE LEAD AND THEIR POST-DOC.

1307
01:04:54,440 --> 01:04:58,560
YOU'LL SEE THE NEI HAD FOR 

1308
01:04:58,560 --> 01:05:00,240
DECADES FOR OVER 30 YEARS HAD 

1309
01:05:00,240 --> 01:05:01,960
BEEN STUDYING USHER PATIENTS.

1310
01:05:01,960 --> 01:05:09,680
AND MANY OF THEM A LARGE NUMBER.

1311
01:05:09,680 --> 01:05:15,080
AND WE WENT THROUGH THE 

1312
01:05:15,080 --> 01:05:15,920
INDIVIDUALS AND TRIED TO 

1313
01:05:15,920 --> 01:05:17,120
DETERMINE WHAT THE EXPLANATION 

1314
01:05:17,120 --> 01:05:24,240
WAS FOR THE LOSS OF VISION AND 

1315
01:05:24,240 --> 01:05:26,120
IDENTIFIED 13 INDIVIDUALS WITH A

1316
01:05:26,120 --> 01:05:27,120
MUTATION.

1317
01:05:27,120 --> 01:05:33,680
AND 11 OF THEM WERE HOMOZYGOUS 

1318
01:05:33,680 --> 01:05:37,400
AND TWO HAD ANOTHER MUTANT 

1319
01:05:37,400 --> 01:05:38,640
ALLELE SIMILARLY DISABLING AND 

1320
01:05:38,640 --> 01:05:52,880
DAMAGING TO THE PROTEIN.

1321
01:05:52,880 --> 01:05:55,440
WE LOOKED AT THE VISUAL FIELD 

1322
01:05:55,440 --> 01:05:58,000
THAT WOULD BE DETECTED BY THESE 

1323
01:05:58,000 --> 01:05:59,880
INDIVIDUALS AND I'M SURE IF 

1324
01:05:59,880 --> 01:06:03,280
YOU'VE GONE TO AN 

1325
01:06:03,280 --> 01:06:04,960
OPHTHALMOLOGIST YOU'VE HAD A 

1326
01:06:04,960 --> 01:06:06,840
VISUAL FIELD TEST WHERE THE 

1327
01:06:06,840 --> 01:06:07,800
LIGHTS BLINK IN THE VISUAL FIELD

1328
01:06:07,800 --> 01:06:09,320
AND SOME ARE DIM AND LIGHT AND 

1329
01:06:09,320 --> 01:06:10,760
YOU PRESS A BUTTON IF YOU SEE 

1330
01:06:10,760 --> 01:06:10,960
IT.

1331
01:06:10,960 --> 01:06:14,760
WHAT IS NOTED HERE IS THAT 

1332
01:06:14,760 --> 01:06:18,600
INDIVIDUALS WITH TWO MUTANT 

1333
01:06:18,600 --> 01:06:20,360
ALLELES OF THIS THAT ARE 

1334
01:06:20,360 --> 01:06:23,160
DAMAGING TO THE PROTEIN AND 

1335
01:06:23,160 --> 01:06:31,400
AGAIN 11 ARE HOMEEE  -- 

1336
01:06:31,400 --> 01:06:35,040
HOMOZYGOUS AND THE THERE'S 

1337
01:06:35,040 --> 01:06:36,000
SIGNIFICANT VISION IN THE 

1338
01:06:36,000 --> 01:06:37,760
BEGINNING BUT THEN A RAPID 

1339
01:06:37,760 --> 01:06:39,720
DECLINE IN VISION.

1340
01:06:39,720 --> 01:06:42,920
THESE ARE THE RETINAS FROM SOME 

1341
01:06:42,920 --> 01:06:44,800
OF THESE INDIVIDUALS A 

1342
01:06:44,800 --> 01:06:50,120
19-YEAR-OLD AND 50-YEAR-OLD AND 

1343
01:06:50,120 --> 01:06:53,360
YOU CAN SEE THE DAMAGE THAT'S 

1344
01:06:53,360 --> 01:06:56,360
OCCURRED AND THE COMPARISON TO A

1345
01:06:56,360 --> 01:06:58,440
WILD TYPE RETINA.

1346
01:06:58,440 --> 01:07:00,520
THE PIGMENT AND THE ATTENUATED 

1347
01:07:00,520 --> 01:07:20,600
VESSELS.

1348
01:07:20,600 --> 01:07:25,200
WE SET OUT TO LOOK AT THIS IN A 

1349
01:07:25,200 --> 01:07:26,880
MOUSE AND THERE WERE THOUSANDS 

1350
01:07:26,880 --> 01:07:31,680
OF ALLELES ALREADY STUDIED AND 

1351
01:07:31,680 --> 01:07:34,120
THEY WERE CALLED AMES WALTZER 

1352
01:07:34,120 --> 01:07:36,760
THAT WAS THE NAME GIVEN TO THEM 

1353
01:07:36,760 --> 01:07:39,320
BEFORE WE KNEW THE MUTATION AND 

1354
01:07:39,320 --> 01:07:45,840
IT WAS A GROUP AND MY GROUP THAT

1355
01:07:45,840 --> 01:07:47,000
REPORTED ON THE PHENOTYPE OF 

1356
01:07:47,000 --> 01:07:49,400
THESE AVAILABLE MUTANT ALLELES 

1357
01:07:49,400 --> 01:07:51,960
BUT WE WANTED EXACTLY THE SAME 

1358
01:07:51,960 --> 01:07:53,800
MUTATION TO STUDY IN A MOUSE 

1359
01:07:53,800 --> 01:08:02,760
MODEL.

1360
01:08:02,760 --> 01:08:06,720
SO WHAT'S SHOWN HERE IS A 

1361
01:08:06,720 --> 01:08:13,760
SCHEMATIC OF AN ELECTRORETINO

1362
01:08:13,760 --> 01:08:16,720
ELECTRORETINOGRAM THAT'S A 

1363
01:08:16,720 --> 01:08:21,120
RESPECTIVE RESPONSE OF THE RODS 

1364
01:08:21,120 --> 01:08:24,040
AND CONES LIGHT RESPONSE AND 

1365
01:08:24,040 --> 01:08:28,000
WHAT WE FOUND IN THIS HOMOZYGOUS

1366
01:08:28,000 --> 01:08:30,760
MOUSE THERE'S A DIMINUTION IN 

1367
01:08:30,760 --> 01:08:31,560
THE SIGNAL.

1368
01:08:31,560 --> 01:08:35,200
IN THE FIRST COLUMN WE LOOKED AT

1369
01:08:35,200 --> 01:08:37,480
MICE ONE-MONTH-OLD HOMOZYGOUS 

1370
01:08:37,480 --> 01:08:39,080
FOR THE MUTATION AND WILD TYPE 

1371
01:08:39,080 --> 01:08:41,600
OR HETEROZYGOUS AND HAVE NORMAL 

1372
01:08:41,600 --> 01:08:44,000
VISION AND NORMAL HEARING AND AT

1373
01:08:44,000 --> 01:08:46,880
2 AND 3 MONTHS AND IN RED ARE 

1374
01:08:46,880 --> 01:08:53,840
THE HOMOZYGOUS MUTANTS AND IN 

1375
01:08:53,840 --> 01:08:55,680
BLACK THE HOMOZYGOUS WILD TYPE 

1376
01:08:55,680 --> 01:08:56,360
INDIVIDUALS WHO HAVE NORMAL 

1377
01:08:56,360 --> 01:09:13,160
HEARING.

1378
01:09:13,160 --> 01:09:17,520
AND THERE'S PHOTOPIC AND THERE'S

1379
01:09:17,520 --> 01:09:20,840
A SIGNIFICANT DIMINUTION OF THE 

1380
01:09:20,840 --> 01:09:22,800
AMPLITUDE IN MICROVOLTS IN THE 

1381
01:09:22,800 --> 01:09:25,080
MOUSE EVEN AT ONE MONTH AND AT 

1382
01:09:25,080 --> 01:09:26,640
TWO TO THREE MONTHS AND 

1383
01:09:26,640 --> 01:09:29,360
ADDITIONAL DATA IN THE PAPER AT 

1384
01:09:29,360 --> 01:09:34,560
SIX MONTHS AND SOME AT A YEAR.

1385
01:09:34,560 --> 01:09:37,720
SO, THAT MEANS A LOSS OF 15 

1386
01:09:37,720 --> 01:09:50,240
PROTEIN DUE TO HOMO ZYGOCITY 

1387
01:09:50,240 --> 01:09:57,760
LEADS TO DYSFUNCTION.

1388
01:09:57,760 --> 01:10:03,600
DR. AHMED LOOKED AT THE ROD 

1389
01:10:03,600 --> 01:10:08,160
OUTER SEGMENT INVOLVED IN THE 

1390
01:10:08,160 --> 01:10:12,560
VISUAL RETINOID CYCLE AND 

1391
01:10:12,560 --> 01:10:20,680
TRANSDUCENT AND WHEN THE ANIMAL

1392
01:10:20,680 --> 01:10:22,640
ANIMAL'S LIGHT ADAPTED BUT IN 

1393
01:10:22,640 --> 01:10:26,760
THE MUTANT MOUSE THE ARRESTED 

1394
01:10:26,760 --> 01:10:28,440
AND TRANSDUCENT WERE IN THE 

1395
01:10:28,440 --> 01:10:34,560
INNER SEGMENT AND OUTER SEGMENT.

1396
01:10:34,560 --> 01:10:37,080
TRANSDUCENT IS IN BOTH SEGMENTS 

1397
01:10:37,080 --> 01:10:42,960
AND NOT SO IN THE WILD TYPE.

1398
01:10:42,960 --> 01:10:48,120
THAT MEANS THEY'RE MISLOCALIZED 

1399
01:10:48,120 --> 01:10:50,000
WHEN THIS IS ACCEPT.

1400
01:10:50,000 --> 01:10:52,080
-- ABSENT.

1401
01:10:52,080 --> 01:10:56,760
WHAT I HAVEN'T SHOWN IS THE DATA

1402
01:10:56,760 --> 01:10:59,760
FROM MICHAEL REDMAN'S LAB THESE 

1403
01:10:59,760 --> 01:11:05,880
MICE HAVE REDUCED LEVELS OF THE 

1404
01:11:05,880 --> 01:11:10,280
ENDOGENOUS NATIONALLY OCCURRING 

1405
01:11:10,280 --> 01:11:17,760
RETINALE TO FORM REDOXIN IN THE 

1406
01:11:17,760 --> 01:11:19,800
PHOTO TRANSDUCTION CASCADE ON 

1407
01:11:19,800 --> 01:11:21,480
THE TIME SCALE.

1408
01:11:21,480 --> 01:11:25,360
BECAUSE THERE WAS A DEFICIENCY 

1409
01:11:25,360 --> 01:11:33,320
THE HYPOTHESIS WAS THAT PERHAPS 

1410
01:11:33,320 --> 01:11:38,360
NINE CIS RETINAL ANALOG 

1411
01:11:38,360 --> 01:11:41,320
AVAILABLE WILL IMPROVE THE ERG 

1412
01:11:41,320 --> 01:11:44,760
MAGNITUDE OF THE HOMOZYGOUS 

1413
01:11:44,760 --> 01:11:46,840
R250X MUTANT MOUSE AND IF SO 

1414
01:11:46,840 --> 01:12:10,720
MAYBE IT WOULD WORK IN HUMANS.

1415
01:12:10,720 --> 01:12:12,440
YOU CAN SEE THE DIMINUTION AND 

1416
01:12:12,440 --> 01:12:15,720
ONE WEEK LATER THERE WAS A 

1417
01:12:15,720 --> 01:12:16,560
SINGLE INTERJECTION OF A 

1418
01:12:16,560 --> 01:12:19,360
QUARTERLY OF A MILLIGRAM OF THE 

1419
01:12:19,360 --> 01:12:22,360
RETINAL INJECTED INTO THE MOUSE 

1420
01:12:22,360 --> 01:12:27,040
AND THEN 24 HOURS LATER THE ERGs

1421
01:12:27,040 --> 01:12:29,360
WERE MEASURES AND THEY'RE VERY 

1422
01:12:29,360 --> 01:12:31,360
SIMILAR TO THE WILD TYPE AND 

1423
01:12:31,360 --> 01:12:35,360
WHEN THAT'S QUANTIFIED, THE 

1424
01:12:35,360 --> 01:12:36,960
HOMOZYGOUS MUTANT INJECTED IN 

1425
01:12:36,960 --> 01:12:43,920
PURPLE IS VERY SIMILAR IN 

1426
01:12:43,920 --> 01:12:45,720
MAGNITUDE TO THE WILD TYPE 

1427
01:12:45,720 --> 01:12:48,360
INJECTED CONTROLS AND DIFFERENT 

1428
01:12:48,360 --> 01:13:02,080
FROM THE BASELINE.

1429
01:13:02,080 --> 01:13:03,520
SO CLOSING THOUGHTS.

1430
01:13:03,520 --> 01:13:06,360
I HOPE THIS HAS SHOWED THE LONG 

1431
01:13:06,360 --> 01:13:08,880
ARC OF SCIENCE WHICH I THAT'D 

1432
01:13:08,880 --> 01:13:12,000
PRIVILEGE OF PURSUING IN THE 

1433
01:13:12,000 --> 01:13:15,760
PROGRAM AND IT'S NOT BEEN LOST 

1434
01:13:15,760 --> 01:13:18,720
ON ME IT'S GOING TO TAKE A LONG 

1435
01:13:18,720 --> 01:13:27,800
TIME TO SEE IF THESE RETINOID 

1436
01:13:27,800 --> 01:13:29,360
COMPOUNDS MAY BE EFFECTING.

1437
01:13:29,360 --> 01:13:33,040
THE IDENTIFICATION OF THE 

1438
01:13:33,040 --> 01:13:34,360
GENETIC CAUSES AND WILD TYPE 

1439
01:13:34,360 --> 01:13:36,960
MECHANISMS AND PATHOPHYSIOLOGY 

1440
01:13:36,960 --> 01:13:38,800
OF INHERITED DISORDERS IN 

1441
01:13:38,800 --> 01:13:41,080
COMBINATION WITH ANIMAL MODELS 

1442
01:13:41,080 --> 01:13:42,480
MAY REVEAL BENEFICIAL 

1443
01:13:42,480 --> 01:13:42,920
INTERVENTIONS.

1444
01:13:42,920 --> 01:13:46,040
WHAT I TOLD YOU ABOUT MAY BE 

1445
01:13:46,040 --> 01:13:46,440
ONE.

1446
01:13:46,440 --> 01:13:53,920
IN THE R245X VARIANT IS 

1447
01:13:53,920 --> 01:13:58,240
EQUIVALENT TO MOUSE R250X BUT A 

1448
01:13:58,240 --> 01:14:01,280
MOUSE RETINA IS NOT A HUMAN 

1449
01:14:01,280 --> 01:14:02,840
RETINA AND A TRIAL OF THE 

1450
01:14:02,840 --> 01:14:06,120
COMPOUNDS TO REDUCE VISION LOSS 

1451
01:14:06,120 --> 01:14:07,800
IN SUBJECTS AND MAYBE OTHER 

1452
01:14:07,800 --> 01:14:11,160
USHER SUBJECTS MAY TAKE YEARS TO

1453
01:14:11,160 --> 01:14:13,040
DETERMINE THE PHARMACO 

1454
01:14:13,040 --> 01:14:13,400
RESPONSIVENESS.

1455
01:14:13,400 --> 01:14:15,040
I HOPE I'VE GIVEN YOU A FLAVOR 

1456
01:14:15,040 --> 01:14:20,440
FOR THAT PAPER AND FOR THE 

1457
01:14:20,440 --> 01:14:21,840
RESEARCH IN MY LAB AND I'M HAPPY

1458
01:14:21,840 --> 01:14:24,560
TO ANSWER ANY QUESTIONS YOU 

1459
01:14:24,560 --> 01:14:36,680
MIGHT HAVE.

1460
01:14:36,680 --> 01:14:44,360
THANK YOU, TOM 37  -- THANK YOU,

1461
01:14:44,360 --> 01:14:58,280
TOM.

1462
01:14:58,280 --> 01:15:00,760
>> CAN YOU ELABORATE HOW THE 

1463
01:15:00,760 --> 01:15:02,400
MOLECULE AFFECTS -- I THINK 

1464
01:15:02,400 --> 01:15:08,680
YOU'VE BEEN INSTRUMENTAL IN OUR 

1465
01:15:08,680 --> 01:15:11,560
UNDERSTANDING OF WHAT IT DOES IN

1466
01:15:11,560 --> 01:15:17,200
THE COCHLEA BUT ELABORATE ON 

1467
01:15:17,200 --> 01:15:26,720
COMMONALITIES WITH THE RETINA.

1468
01:15:26,720 --> 01:15:27,840
>> THERE'S' TERRIFIC QUESTION 

1469
01:15:27,840 --> 01:15:31,120
AND IT'S ONE OF TWO PROTEINS 

1470
01:15:31,120 --> 01:15:35,280
THAT MAKE UP THE CELLS THAT GATE

1471
01:15:35,280 --> 01:15:37,840
THE TRANSDUCTION CHANNEL.

1472
01:15:37,840 --> 01:15:38,680
WE KNOW WHAT IT DOES IN THE 

1473
01:15:38,680 --> 01:15:47,920
AUDITORY SYSTEM.

1474
01:15:47,920 --> 01:15:49,560
WE STILL DON'T FULLY UNDERSTAND 

1475
01:15:49,560 --> 01:15:52,160
THE FUNCTION IN THE RETINA AND 

1476
01:15:52,160 --> 01:15:57,240
THERE'S PAPERS WE DON'T FULLY 

1477
01:15:57,240 --> 01:16:01,000
UNDERSTAND THE FUNCTION.

1478
01:16:01,000 --> 01:16:05,160
IT'S A PROJECT ONGOING AND MANY 

1479
01:16:05,160 --> 01:16:06,880
WORKING ON THIS INCLUDING 

1480
01:16:06,880 --> 01:16:08,400
ANOTHER LAB.

1481
01:16:08,400 --> 01:16:11,560
I CAN'T GIVE YOU A GOOD ANSWER 

1482
01:16:11,560 --> 01:16:13,640
TO THAT QUESTION.

1483
01:16:13,640 --> 01:16:16,680
THE OTHER THING THAT'S 

1484
01:16:16,680 --> 01:16:18,600
PERPLEXING ABOUT THIS IS THAT IT

1485
01:16:18,600 --> 01:16:21,040
ALMOST EVERY SINGLE ONE OF ITS 

1486
01:16:21,040 --> 01:16:27,320
MANY MANY AXONS ARE 

1487
01:16:27,320 --> 01:16:28,840
ALTERNATIVELY SPLICED AND 

1488
01:16:28,840 --> 01:16:30,720
THERE'S A HUGE NUMBER OF THE ISO

1489
01:16:30,720 --> 01:16:33,280
FORMS IN THE PROTEIN AND EACH 

1490
01:16:33,280 --> 01:16:34,560
MAY BE DOING SOMETHING A LITTLE 

1491
01:16:34,560 --> 01:16:37,280
DIFFERENT.

1492
01:16:37,280 --> 01:16:39,280
MOREOVER, THERE'S A -- SO IT'S A

1493
01:16:39,280 --> 01:16:40,560
TRANS MEMBRANE PROTEIN.

1494
01:16:40,560 --> 01:16:42,400
MOST IS OUTSIDE THE CELL AND 

1495
01:16:42,400 --> 01:16:45,920
THERE'S SOME OF IT WHEN I SIDE 

1496
01:16:45,920 --> 01:16:52,360
THE CELL AND THERE'S THREE 

1497
01:16:52,360 --> 01:16:53,920
CYTOPLASMIC DOMAINS AND NO ONE 

1498
01:16:53,920 --> 01:16:55,920
IS WORKING ON THIS THERE'S A 

1499
01:16:55,920 --> 01:16:59,360
SECRETED FORM OF THE PROTEIN 

1500
01:16:59,360 --> 01:17:00,520
WHICH WE REPORTED PROBABLY 10 

1501
01:17:00,520 --> 01:17:09,560
YEARS AGO.

1502
01:17:09,560 --> 01:17:11,160
I THINK IT'S GOING TO BE A LONG 

1503
01:17:11,160 --> 01:17:13,480
TIME BEFORE WE FULLY UNDERSTAND 

1504
01:17:13,480 --> 01:17:15,360
THE FUNCTIONS OF THIS.

1505
01:17:15,360 --> 01:17:19,360
>> DO YOU THINK THAT EXPLAINS 

1506
01:17:19,360 --> 01:17:21,760
THE PROGRESSIVE NATURE THAT 

1507
01:17:21,760 --> 01:17:25,600
COULD BE DIFFERENT ISOFORMS AT 

1508
01:17:25,600 --> 01:17:28,880
DIFFERENT TIMES AND AFFECTING 

1509
01:17:28,880 --> 01:17:32,560
THE TWO SENSORY SYSTEMS?

1510
01:17:32,560 --> 01:17:34,560
>> IT'S A POSSIBILITY.

1511
01:17:34,560 --> 01:17:37,760
THE REASON WE MADE THE MOUSE IS 

1512
01:17:37,760 --> 01:17:41,400
IT'S ONE AXON IN ALMOST EVERY 

1513
01:17:41,400 --> 01:17:44,840
ONE OF THE ISOFORMS AND SO IT'S 

1514
01:17:44,840 --> 01:17:50,840
REALLY AN ALLELE AND OTHERS 

1515
01:17:50,840 --> 01:17:51,480
AREN'T PERHAPS NECESSARY IN THE 

1516
01:17:51,480 --> 01:17:54,200
EYE.

1517
01:17:54,200 --> 01:17:55,240
IT'S A LITTLE MORE COMPLICATED 

1518
01:17:55,240 --> 01:17:58,200
THAN SAYING A DAMAGED PROTEIN 

1519
01:17:58,200 --> 01:18:00,160
THAT FUNCTIONS IN THE RETINA.

1520
01:18:00,160 --> 01:18:06,360
THAT'S AN OVER SIMPLIFICATION.

1521
01:18:06,360 --> 01:18:10,160
>> LIKE DYSTROPHIN.

1522
01:18:10,160 --> 01:18:11,440
>> THAT'S A WHOLE OTHER STORY 

1523
01:18:11,440 --> 01:18:12,320
AND THANK YOU FOR BRINGING IT 

1524
01:18:12,320 --> 01:18:13,280
UP.

1525
01:18:13,280 --> 01:18:27,760
>> THANK YOU.

1526
01:18:27,760 --> 01:18:29,760
>> I WOULD TAKE A GENETIC COURSE

1527
01:18:29,760 --> 01:18:35,920
AT MICHIGAN STATE AS A FRESHMAN.

1528
01:18:35,920 --> 01:18:37,760
40 YEARS BETWEEN THAT TIME AND 

1529
01:18:37,760 --> 01:18:41,480
NOW.

1530
01:18:41,480 --> 01:18:47,840
YOUR LAST COMMENT ABOUT HOW 

1531
01:18:47,840 --> 01:18:50,680
SEEING THE PHARMACO OR GENE 

1532
01:18:50,680 --> 01:18:51,120
THERAPY.

1533
01:18:51,120 --> 01:18:56,240
I FEEL THE SAME THING MAY BE BE 

1534
01:18:56,240 --> 01:18:58,680
APPLIED TO AGE RELATED HEARING 

1535
01:18:58,680 --> 01:19:00,120
LOSS AND YOUR THOUGHTS OF THE 

1536
01:19:00,120 --> 01:19:01,560
HEARING ASPECT AND INTERVENTION 

1537
01:19:01,560 --> 01:19:09,000
FOR HEARING IMPAIRMENT.

1538
01:19:09,000 --> 01:19:15,440
COCHLEAR IMPLANTS WORK FOR 

1539
01:19:15,440 --> 01:19:17,960
ALMOST ALL THE INDIVIDUALS WITH 

1540
01:19:17,960 --> 01:19:20,520
SEARCH GENES AND WITH TYPE 1 YOU

1541
01:19:20,520 --> 01:19:23,840
HAVE TO INTERVENE EARLY BEFORE 

1542
01:19:23,840 --> 01:19:29,320
THERE'S A LOSS OF HAIR CELLS.

1543
01:19:29,320 --> 01:19:34,600
IT'S A GOOD QUESTION AND I DON'T

1544
01:19:34,600 --> 01:19:37,600
HAVE GREAT ANSWERS BUT WE'RE 

1545
01:19:37,600 --> 01:19:41,840
REFORMING THE USHER GROUP AT NIH

1546
01:19:41,840 --> 01:19:42,480
AND THE FIRST ISSUE'S GOING TO 

1547
01:19:42,480 --> 01:19:44,280
BE HOW TO INITIATE A CLINICAL 

1548
01:19:44,280 --> 01:19:46,360
TRIAL.

1549
01:19:46,360 --> 01:19:49,120
I SUPPOSE WE OUGHT TO BE 

1550
01:19:49,120 --> 01:19:53,640
THINKING ABOUT SINCE IT'S AN 

1551
01:19:53,640 --> 01:19:56,640
NIDC/NEI GROUP WE OUGHT TO BE 

1552
01:19:56,640 --> 01:19:57,240
THINKING ABOUT THE HEARING AS 

1553
01:19:57,240 --> 01:20:00,440
WELL AS THE VISION.

1554
01:20:00,440 --> 01:20:02,520
I HOPE I'M AROUND TO FIND 

1555
01:20:02,520 --> 01:20:06,160
WHETHER ANY OF THE INTERVENTIONS

1556
01:20:06,160 --> 01:20:12,120
WORK AND SURELY COCHLEAR 

1557
01:20:12,120 --> 01:20:13,680
IMPLANTS WORK AND THAT'S BEEN 

1558
01:20:13,680 --> 01:20:14,200
AROUND MANY YEARS IN MANY 

1559
01:20:14,200 --> 01:20:19,040
PATIENTS.

1560
01:20:19,040 --> 01:20:19,760
>> ALL RIGHT.

1561
01:20:19,760 --> 01:20:21,480
TOM, THANK YOU SO MUCH.

1562
01:20:21,480 --> 01:20:26,320
I REALLY APPRECIATE THE EXCITING

1563
01:20:26,320 --> 01:20:26,720
PRESENTATION.

1564
01:20:26,720 --> 01:20:28,600
SO WE'LL GO TO A SHORT BREAK.

1565
01:20:28,600 --> 01:20:30,760
DON'T GET OFF THE ZOOM LINK BUT 

1566
01:20:30,760 --> 01:20:33,000
MUTE AND TURN OFF YOUR CAMERAS 

1567
01:20:33,000 --> 01:20:35,000
AND SEE YOU AT 2:30.

1568
01:20:35,000 --> 01:20:39,680
>> HOPEFULLY EVERYBODY IS BACK 

1569
01:20:39,680 --> 01:20:43,360
FROM THE SHORT BREAK AND WE'LL 

1570
01:20:43,360 --> 01:20:45,920
AN UPDATE WITH OUR PLANNING 

1571
01:20:45,920 --> 01:20:47,040
BRANCH AND COUNCIL MEMBERS 

1572
01:20:47,040 --> 01:20:49,600
REPRESENTING COUNCIL IN THIS 

1573
01:20:49,600 --> 01:20:52,840
EFFORT, DR. CHAUDHARI AND SANES.

1574
01:20:52,840 --> 01:20:56,680
>> CAN YOU HEAR ME ALL RIGHT?

1575
01:20:56,680 --> 01:20:57,240
>> YES.

1576
01:20:57,240 --> 01:20:58,400
>> THANK YOU.

1577
01:20:58,400 --> 01:20:59,640
I'M PLEASED TO BE WITH YOU TO 

1578
01:20:59,640 --> 01:21:02,040
UPDATE YOU ON THE STRATEGIC 

1579
01:21:02,040 --> 01:21:11,680
PLANNING PROCESS.

1580
01:21:11,680 --> 01:21:14,560
SPECIFICALLY ABOUT OUR IDEA 

1581
01:21:14,560 --> 01:21:15,720
GENERATION MEETING AND WE'LL GET

1582
01:21:15,720 --> 01:21:35,840
THOUGHTS ON HOW THINGS WENT.

1583
01:21:35,840 --> 01:21:37,600
>> I WANT TO TALK GOOD THE 

1584
01:21:37,600 --> 01:21:38,200
STRATEGIC PLAN AND THE PLANNED 

1585
01:21:38,200 --> 01:21:46,480
NEXT STEPS.

1586
01:21:46,480 --> 01:21:47,960
SO THE PURPOSE OF THE NIDCD 

1587
01:21:47,960 --> 01:21:49,800
STRATEGIC PLAN TO REMIND US ALL 

1588
01:21:49,800 --> 01:21:55,520
SO WE'RE ON THE SAME PAGE, WHAT 

1589
01:21:55,520 --> 01:22:04,480
IS THE PLAN AND IDENTIFY AREAS 

1590
01:22:04,480 --> 01:22:06,640
OF OPPORTUNITIES AND GAPS WE 

1591
01:22:06,640 --> 01:22:08,280
NEED TO FILL TO MOVE OUR MISSION

1592
01:22:08,280 --> 01:22:09,920
FORWARD AND NEED TO IDENTIFY TOP

1593
01:22:09,920 --> 01:22:19,160
PRIORITIES FOR THE FUTURE.

1594
01:22:19,160 --> 01:22:21,400
AS WITH YOU NOE WE'VE BEEN USING

1595
01:22:21,400 --> 01:22:24,200
A COLLABORATIVE APPROACH AND 

1596
01:22:24,200 --> 01:22:26,920
BEGIN TO SYNTHESIZE THE CROWD 

1597
01:22:26,920 --> 01:22:28,640
SOURCE AND LINK THEM TO THE 

1598
01:22:28,640 --> 01:22:39,120
MISSION AND VISION ON THE SLIDE.

1599
01:22:39,120 --> 01:22:41,400
BEFORE I MOVE WITH THE TIME LINE

1600
01:22:41,400 --> 01:22:44,840
I WANT TO EMPHASIZE THE 

1601
01:22:44,840 --> 01:22:46,120
STRATEGIC PLAN WILL ADDRESS 

1602
01:22:46,120 --> 01:22:48,240
ADDITIONAL IMPORTANT EFFORTS 

1603
01:22:48,240 --> 01:22:48,960
HAPPENING AT THE INSTITUTE 

1604
01:22:48,960 --> 01:22:50,800
INCLUDING ON DIVERSITY, EQUITY 

1605
01:22:50,800 --> 01:22:56,240
AND INCLUSION IN THE SCIENTIFIC 

1606
01:22:56,240 --> 01:22:59,400
WORKFORCE WORKFORCE YOU'LL HEAR 

1607
01:22:59,400 --> 01:23:00,840
ABOUT TOMORROW AND RESEARCH 

1608
01:23:00,840 --> 01:23:02,360
TRAINING WE'LL TOUCH ON RESEARCH

1609
01:23:02,360 --> 01:23:04,200
TRAINING, WOMEN'S HEALTH, 

1610
01:23:04,200 --> 01:23:05,360
MINORITY HEALTH AND HEALTH 

1611
01:23:05,360 --> 01:23:06,440
DISPARITIES IN THE STRATEGIC 

1612
01:23:06,440 --> 01:23:06,880
PLAN.

1613
01:23:06,880 --> 01:23:09,040
WE'LL BE SURE TO HIGHLIGHT WHAT 

1614
01:23:09,040 --> 01:23:11,640
THE INSTITUTE IS DOING IN THOSE 

1615
01:23:11,640 --> 01:23:17,680
AREAS.

1616
01:23:17,680 --> 01:23:22,960
YOU SAW THIS HIGH LEVEL TIME 

1617
01:23:22,960 --> 01:23:30,880
LINE EARLIER.

1618
01:23:30,880 --> 01:23:31,920
WE'LL END WITH THE STRATEGIC 

1619
01:23:31,920 --> 01:23:33,760
PLAN AND A WANT TO STOP AND 

1620
01:23:33,760 --> 01:23:35,640
ACKNOWLEDGE HOW WE GOT HERE AND 

1621
01:23:35,640 --> 01:23:38,160
THE PANDEMIC'S INFLUENCE ON THIS

1622
01:23:38,160 --> 01:23:46,960
STRATEGIC PLANNING PROCESS.

1623
01:23:46,960 --> 01:23:51,640
IT STARTED WITH A GENERATION OF 

1624
01:23:51,640 --> 01:23:53,960
MEETINGS DISCUSSING IDEAS OVER 

1625
01:23:53,960 --> 01:23:56,080
MEALS AND IN THE FORMAL PARTS OF

1626
01:23:56,080 --> 01:23:57,640
THE MEETING AND DELAYED AND 

1627
01:23:57,640 --> 01:24:01,200
HOPED TO HOLD IN IT PERSON BUT 

1628
01:24:01,200 --> 01:24:02,400
EVENTUALLY ENDED UP MOVING 

1629
01:24:02,400 --> 01:24:03,600
FORWARD VIRTUALLY.

1630
01:24:03,600 --> 01:24:06,080
THE FORMAT OF THE IDEA 

1631
01:24:06,080 --> 01:24:07,040
GENERATION IN DECEMBER WAS 

1632
01:24:07,040 --> 01:24:08,680
DESIGNED FOR AN IN-PERSON 

1633
01:24:08,680 --> 01:24:10,080
EXPERIENCE AND WE ADAPTED IT TO 

1634
01:24:10,080 --> 01:24:16,600
USE TECHNOLOGY TO HANDLE IT 

1635
01:24:16,600 --> 01:24:18,720
VIRTUALLY INSTEAD.

1636
01:24:18,720 --> 01:24:21,600
THOUGH WE HAD TO ADAPT WE GOT 

1637
01:24:21,600 --> 01:24:23,120
GOOD IDEAS IN JULY AND IN 

1638
01:24:23,120 --> 01:24:31,080
DECEMBER AND WE VALUE THEM.

1639
01:24:31,080 --> 01:24:34,200
I WANTED TO SHARE THAT WITH YOU 

1640
01:24:34,200 --> 01:24:35,640
AND AFTER WE KICKED OFF THE 

1641
01:24:35,640 --> 01:24:38,360
MEETING I WANT TO SHARE IDEAS 

1642
01:24:38,360 --> 01:24:43,760
ABOUT THE IDEA MEETING PROCESS 

1643
01:24:43,760 --> 01:24:56,240
AND TALK ABOUT NEXT STEPS.

1644
01:24:56,240 --> 01:25:05,280
THE APPROACH WE PUT EVERYONE 

1645
01:25:05,280 --> 01:25:07,240
TOGETHER IN A VIRTUAL ROOM TO 

1646
01:25:07,240 --> 01:25:13,480
HEAR THE OIFBJECTIVES AND RULES 

1647
01:25:13,480 --> 01:25:15,200
FOR PARTICIPATING AND OPEN THE 

1648
01:25:15,200 --> 01:25:17,600
QUEUE FOR SUBJECT MATTER EXPERTS

1649
01:25:17,600 --> 01:25:17,840
TO.

1650
01:25:17,840 --> 01:25:18,840
I PITCH THEIR IDEAS.

1651
01:25:18,840 --> 01:25:24,840
NEXT WE HAD THE MARKETPLACE 

1652
01:25:24,840 --> 01:25:30,680
IDEAS OF IDEAS WHERE SUBJECT 

1653
01:25:30,680 --> 01:25:32,720
MATTER EXPERTS SPOKE ABOUT IT IN

1654
01:25:32,720 --> 01:25:37,200
THE BREAKOUT SESSION.

1655
01:25:37,200 --> 01:25:39,920
IN THE AFTERNOON ON DAY ONE WE 

1656
01:25:39,920 --> 01:25:42,040
PITCHED THE IDEAS INTO 30 

1657
01:25:42,040 --> 01:25:43,160
BREAKOUT SESSIONS.

1658
01:25:43,160 --> 01:25:48,000
I'LL TALK MORE ABOUT DAY 2 IN A 

1659
01:25:48,000 --> 01:25:48,680
BIT.

1660
01:25:48,680 --> 01:25:51,840
BEHIND THE SCENES ON DAY ONE, 

1661
01:25:51,840 --> 01:25:57,360
NIDCD STAFF LOOKED AT ALL THE 

1662
01:25:57,360 --> 01:26:01,440
IDEAS AND WORKED TO PROGRAM THEM

1663
01:26:01,440 --> 01:26:04,040
INTO BREAKOUT SESSIONS AROUND 

1664
01:26:04,040 --> 01:26:05,720
SELECTED IDEAS FOR FURTHER 

1665
01:26:05,720 --> 01:26:11,400
DISCUSSION AND IN SOL -- INPUT 

1666
01:26:11,400 --> 01:26:13,800
SOME IN TWO SESSIONS.

1667
01:26:13,800 --> 01:26:16,200
WE ENCOURAGED THE SUBJECT MATTER

1668
01:26:16,200 --> 01:26:18,920
EXPERTS TO GO TO THE BREAKOUT 

1669
01:26:18,920 --> 01:26:20,640
SESSIONS THAT INTERESTED THEM 

1670
01:26:20,640 --> 01:26:27,440
AND HOPED TO GET BROAD EXPERTISE

1671
01:26:27,440 --> 01:26:28,160
FROM ACROSS THE MISSION AREAS 

1672
01:26:28,160 --> 01:26:35,920
AND ADD NEW PERSPECTIVES.

1673
01:26:35,920 --> 01:26:38,840
WE FOCUSSED THOSE NOT ALREADY 

1674
01:26:38,840 --> 01:26:45,040
ADDRESSED IN AN ONGOING EFFORT.

1675
01:26:45,040 --> 01:26:47,200
I WON'T READ EVERY ITEM BUT IT'S

1676
01:26:47,200 --> 01:26:49,200
JUST TO GIVE YOU AN I'D ANDSHARE

1677
01:26:49,200 --> 01:26:53,680
HOW WE CONDUCTED DAY DAY 2.

1678
01:26:53,680 --> 01:26:58,040
WE HAD FIVE BREAKOUT ROOMS, A, 

1679
01:26:58,040 --> 01:27:01,440
B, C, D AND E AND HELD SIX 

1680
01:27:01,440 --> 01:27:07,000
ROUNDS OF VIRTUAL BREAKOUT ROOM 

1681
01:27:07,000 --> 01:27:10,960
DISCUSSIONS IN THOSE ROOMS THREE

1682
01:27:10,960 --> 01:27:13,520
IN THE MORNING AND THREE IN THE 

1683
01:27:13,520 --> 01:27:13,960
AFTERNOON.

1684
01:27:13,960 --> 01:27:15,560
BASED ON THE FEEDBACK WE'VE 

1685
01:27:15,560 --> 01:27:17,480
GOTTEN FROM PEOPLE WE HEARD FROM

1686
01:27:17,480 --> 01:27:20,200
WHO ATTENDED AND FROM OUR OWN 

1687
01:27:20,200 --> 01:27:21,640
ATTENDANCE AT THE BREAKOUT 

1688
01:27:21,640 --> 01:27:25,640
SESSIONS WE UNDERSTAND EACH OF 

1689
01:27:25,640 --> 01:27:28,280
THESE ROOMS WERE THEIR OWN 

1690
01:27:28,280 --> 01:27:29,120
UNIQUE EXPERIENCE.

1691
01:27:29,120 --> 01:27:32,520
NEXT WE'LL HEAR FROM NIRUPA AND 

1692
01:27:32,520 --> 01:27:34,240
DAN SHARING THEIR IMPRESSIONS 

1693
01:27:34,240 --> 01:27:36,560
ABOUT SELECT BREAKOUTS THEY 

1694
01:27:36,560 --> 01:27:37,960
ATTENDED.

1695
01:27:37,960 --> 01:27:39,600
NIRUPA, I'LL ASK TO YOU SPEAK 

1696
01:27:39,600 --> 01:27:39,800
NEXT.

1697
01:27:39,800 --> 01:27:48,720
THANK YOU.

1698
01:27:48,720 --> 01:27:50,600
>> THANK YOU, LAURA.

1699
01:27:50,600 --> 01:27:53,760
THIS WAS A UNIQUE EXPERIENCE, I 

1700
01:27:53,760 --> 01:27:56,000
HAVE TO SAY.

1701
01:27:56,000 --> 01:27:59,760
I'LL GIVE YOU A FLAVOR OF TWO 

1702
01:27:59,760 --> 01:28:00,480
SESSIONS.

1703
01:28:00,480 --> 01:28:05,800
I ATTENDED SIX.

1704
01:28:05,800 --> 01:28:07,840
ONE OF THESE WAS IN THE AREA OF 

1705
01:28:07,840 --> 01:28:08,040
NIDCD.

1706
01:28:08,040 --> 01:28:11,440
THE QUESTION WAS WE TALKED ABOUT

1707
01:28:11,440 --> 01:28:13,200
HOW TASTE GUIDES EVERYTHING AND 

1708
01:28:13,200 --> 01:28:15,120
BEHAVIOR BUT WE DON'T HAVE A 

1709
01:28:15,120 --> 01:28:18,520
GOOD CONTINUOUS UNDERSTANDING OF

1710
01:28:18,520 --> 01:28:20,200
WHAT THAT MEANS.

1711
01:28:20,200 --> 01:28:26,080
THE NEURONAL TYPES AND BRAIN 

1712
01:28:26,080 --> 01:28:34,720
CIRCUITS AND BEHAVIORS THE MET 

1713
01:28:34,720 --> 01:28:36,280
 -- THE METABOLIC OUTCOMES AND 

1714
01:28:36,280 --> 01:28:39,600
HOW IT CHANGES WITH METABOLISM 

1715
01:28:39,600 --> 01:28:41,120
OUTCOMES AND ACROSS THE NORMAL 

1716
01:28:41,120 --> 01:28:46,480
LIFE SPAN AND NORMAL AGING.

1717
01:28:46,480 --> 01:28:48,960
THIS WAS A WONDERFUL FREE FOR 

1718
01:28:48,960 --> 01:28:52,800
ALL WITH A LOT OF IDEAS HOW 

1719
01:28:52,800 --> 01:28:54,480
NUTRITIONAL STATES INFLUENCE 

1720
01:28:54,480 --> 01:28:56,800
THINGS AND PERHAPS HOW DOES THE 

1721
01:28:56,800 --> 01:28:59,800
TASTE SYSTEM INFLUENCE 

1722
01:28:59,800 --> 01:29:02,040
NUTRITIONAL DECISIONS.

1723
01:29:02,040 --> 01:29:04,360
WHICH OF COURSE, INTERN AFFECTS 

1724
01:29:04,360 --> 01:29:07,360
METABOLISM BUT IN CONVERSE, HOW 

1725
01:29:07,360 --> 01:29:10,760
DOES WHAT YOU EAT AFFECT YOUR 

1726
01:29:10,760 --> 01:29:16,000
TASTE SENSITIVITIES, 

1727
01:29:16,000 --> 01:29:17,680
PERCEPTIONS, ALL THESE THINGS.

1728
01:29:17,680 --> 01:29:23,480
THERE WAS HIGH ENTHUSIASM FOR 

1729
01:29:23,480 --> 01:29:31,800
PEOPLE TO LOOK AT THE NEURAL 

1730
01:29:31,800 --> 01:29:34,320
IMPACT AND NOT LOOKED AT IN ANY 

1731
01:29:34,320 --> 01:29:37,600
INTEGRATED WAY AND THE OTHER WAS

1732
01:29:37,600 --> 01:29:41,840
ON THE SENSORY AREAS THE NIDCD 

1733
01:29:41,840 --> 01:29:44,240
MISSION AREA OLFACTION WHICH HAS

1734
01:29:44,240 --> 01:29:47,000
RECEIVED ENTHUSIASTIC INTEREST 

1735
01:29:47,000 --> 01:29:52,640
OF LATE WITH COVID-RELATED 

1736
01:29:52,640 --> 01:30:03,600
SYMPTOMS TO LAY OUT WHAT THE 

1737
01:30:03,600 --> 01:30:06,800
MATRIX OF SYMPTOMS ARE AND LOOK 

1738
01:30:06,800 --> 01:30:08,680
AT THE VARIOUS ETIOLOGIES 

1739
01:30:08,680 --> 01:30:11,600
WHETHER THEY'RE VIRAL OR AGING 

1740
01:30:11,600 --> 01:30:17,040
OR TRAUMA OR IDIOPATHIC ALL 

1741
01:30:17,040 --> 01:30:18,640
THOSE THINGS AND ALSO LOOK AT 

1742
01:30:18,640 --> 01:30:21,640
THE TISSUE ORIGINS OF THESE 

1743
01:30:21,640 --> 01:30:22,120
THINGS WHETHER THEY'RE 

1744
01:30:22,120 --> 01:30:29,000
EPITHELIAL OR INFLAMMATORY OR 

1745
01:30:29,000 --> 01:30:30,600
NEURODEGENERATIVE AND INTEGRATE 

1746
01:30:30,600 --> 01:30:35,640
THESE INTO 10 POTENTIAL 

1747
01:30:35,640 --> 01:30:44,920
THERAPIES WAS ONE OF THE HIGH 

1748
01:30:44,920 --> 01:30:46,360
LEVEL GOALS AND TRAININGS AND 

1749
01:30:46,360 --> 01:30:50,600
THERAPIES AND EXISTING COURSES.

1750
01:30:50,600 --> 01:30:53,440
THERE WAS A LOT OF ENTHUSIASM I 

1751
01:30:53,440 --> 01:30:56,840
HEARD FROM P.I.s ABOUT SOME OF 

1752
01:30:56,840 --> 01:30:58,200
THESE AREAS OF OPPORTUNITY 

1753
01:30:58,200 --> 01:31:02,040
THAT -- I MEAN, THERE WAS 

1754
01:31:02,040 --> 01:31:06,760
ENTHUSIASM FOR NIDCD PROMOTING 

1755
01:31:06,760 --> 01:31:10,600
THE AREAS OF OPPORTUNITY AND 

1756
01:31:10,600 --> 01:31:13,520
INITIATIVES BROUGHT IN LIKE THE 

1757
01:31:13,520 --> 01:31:17,200
R25s TO SUPPORT ONGOING RESEARCH

1758
01:31:17,200 --> 01:31:21,360
BY PHYSICIAN SCIENTISTS.

1759
01:31:21,360 --> 01:31:23,360
THAT WAS VERY VERY 

1760
01:31:23,360 --> 01:31:24,880
ENTHUSIASTICALLY RECEIVED.

1761
01:31:24,880 --> 01:31:27,200
AND ALSO THE CONFERENCES AND 

1762
01:31:27,200 --> 01:31:32,640
WORKSHOPS AND I WAS EXCITED TO 

1763
01:31:32,640 --> 01:31:34,720
HEAR THE DISCUSSION EARLIER 

1764
01:31:34,720 --> 01:31:36,440
TODAY WORKSHOP TO BRING TOGETHER

1765
01:31:36,440 --> 01:31:41,960
GRANT RECIPIENTS IN 

1766
01:31:41,960 --> 01:31:43,440
INTERSECTIONAL AREAS AND THINGS 

1767
01:31:43,440 --> 01:31:45,800
PERHAPS NOT YET PUBLISHED AND 

1768
01:31:45,800 --> 01:31:50,040
THINGS TO ENHANCE THOSE 

1769
01:31:50,040 --> 01:31:52,960
INTERSECTIONAL INTERACTIONS.

1770
01:31:52,960 --> 01:32:01,080
SO THOSE WERE SOME OF THE MAIN 

1771
01:32:01,080 --> 01:32:03,640
POINTS I TOOK FROM THE TWO 

1772
01:32:03,640 --> 01:32:04,760
BREAKOUT SESSIONS.

1773
01:32:04,760 --> 01:32:05,760
>> THANK YOU.

1774
01:32:05,760 --> 01:32:07,600
NOW DAN WILL SHARE HIS THOUGHTS.

1775
01:32:07,600 --> 01:32:11,280
>> I HAD A GREAT TIME AT THIS.

1776
01:32:11,280 --> 01:32:12,280
I APPLAUD THE PROGRAM STAFF FOR 

1777
01:32:12,280 --> 01:32:17,680
FIGURING OUT A WAY TO PUT 

1778
01:32:17,680 --> 01:32:22,000
TOGETHER AN IMAGINATIVE 

1779
01:32:22,000 --> 01:32:23,800
INTERACTION FROM PEOPLE ALL OVER

1780
01:32:23,800 --> 01:32:26,040
THE UNITED STATES.

1781
01:32:26,040 --> 01:32:27,200
THERE WERE REAL ADVANTAGES 

1782
01:32:27,200 --> 01:32:28,040
PERHAPS SOME OVER A LIVE 

1783
01:32:28,040 --> 01:32:28,760
MEETING.

1784
01:32:28,760 --> 01:32:30,200
ONE OF THEM WAS THE IDEA THAT WE

1785
01:32:30,200 --> 01:32:32,880
COULD LISTEN TO EACH OTHER 

1786
01:32:32,880 --> 01:32:34,880
PRESENT INDIVIDUALLY BIG IDEAS 

1787
01:32:34,880 --> 01:32:36,720
IN THE FIRST DAY AND THEN HAVE 

1788
01:32:36,720 --> 01:32:40,320
OVERNIGHT TO CONSOLE DATE WHILE 

1789
01:32:40,320 --> 01:32:42,840
THE PROGRAM STAFF PUT EVERYTHING

1790
01:32:42,840 --> 01:32:44,120
TOGETHER AND PROGRAMMED IT FOR 

1791
01:32:44,120 --> 01:32:48,120
US, A MINOR MIRACLE TO TAKE 50 

1792
01:32:48,120 --> 01:32:50,080
IDEAS AND PUT IT INTO DIFFERENT 

1793
01:32:50,080 --> 01:32:51,560
BOX.

1794
01:32:51,560 --> 01:32:53,440
THAT WELL CAN BE AN AVERAGE EVEN

1795
01:32:53,440 --> 01:32:55,200
IF WE WERE ALLOWED TO MEET LIVE 

1796
01:32:55,200 --> 01:32:56,480
TO HAVE ONE OF THESE THINGS.

1797
01:32:56,480 --> 01:33:04,080
THE NEXT DAY, UN LIKE NIRUPA I 

1798
01:33:04,080 --> 01:33:05,240
ATTENDED ONE CALLED THE 

1799
01:33:05,240 --> 01:33:07,360
DEVELOPMENT OF TREATMENT 

1800
01:33:07,360 --> 01:33:09,680
STRATEGIES TO TARGET CENTRAL 

1801
01:33:09,680 --> 01:33:10,600
VESTIBULAR SYSTEM.

1802
01:33:10,600 --> 01:33:13,040
I DON'T WORK IN THE VESTIBULAR 

1803
01:33:13,040 --> 01:33:14,640
SYSTEM BUT AS SOMEONE WHO WORKS 

1804
01:33:14,640 --> 01:33:16,800
ON THE CENTRAL AUDITORY SYSTEM I

1805
01:33:16,800 --> 01:33:18,440
WAS INTERESTED HOW THESE GUYS 

1806
01:33:18,440 --> 01:33:19,560
WERE THINKING WHAT A TARGET 

1807
01:33:19,560 --> 01:33:20,560
MEANS.

1808
01:33:20,560 --> 01:33:22,520
WHAT DO YOU MEAN BY A TARGET?

1809
01:33:22,520 --> 01:33:25,040
IS IT A SYNAPTIC AREA OR AREA OF

1810
01:33:25,040 --> 01:33:26,680
THE BRAIN AND SO FORTH AND HOW 

1811
01:33:26,680 --> 01:33:29,400
MIGHT THESE THINGS IMPACT THE 

1812
01:33:29,400 --> 01:33:31,640
BEHAVIORAL DEFICITS THAT OCCUR 

1813
01:33:31,640 --> 01:33:33,440
WITH VESTIBULAR DISORDERS.

1814
01:33:33,440 --> 01:33:39,200
I PARTICIPATED AS SOMEBODY MORE 

1815
01:33:39,200 --> 01:33:45,440
ASKING QUESTIONS THAN OFFERING 

1816
01:33:45,440 --> 01:33:47,560
IDEAS AND IT WILL BE INTERESTING

1817
01:33:47,560 --> 01:33:48,960
HOW IT TURNS OUT IN THE LONG RUN

1818
01:33:48,960 --> 01:33:51,840
AND IN THE AFTERNOON I WENT TO 

1819
01:33:51,840 --> 01:33:54,200
ONE THAT CONSIDERED ADDING 

1820
01:33:54,200 --> 01:33:55,640
COMMUNICATION PHENOTYPES TO 

1821
01:33:55,640 --> 01:34:01,400
LARGE SCALE EPIDEMIOLOGICAL 

1822
01:34:01,400 --> 01:34:03,400
COHORTS INCLUDING LIKE ANOTHER N

1823
01:34:03,400 --> 01:34:13,040
HANES STUDY AND I WORK ON THE 

1824
01:34:13,040 --> 01:34:14,880
DEFICITS THAT OCCUR AFTER 

1825
01:34:14,880 --> 01:34:16,880
HEARING LOSS AND PUSHED WE HAVE 

1826
01:34:16,880 --> 01:34:19,040
TO INCLUDE LONGITUDINAL STUDIES 

1827
01:34:19,040 --> 01:34:22,600
WHEN WE TALK ABOUT THESE THINGS 

1828
01:34:22,600 --> 01:34:24,000
THOSE PROVIDE THE LONGEST 

1829
01:34:24,000 --> 01:34:25,600
LONG-TERM BENEFIT FOR THOSE 

1830
01:34:25,600 --> 01:34:27,000
CONSTRUCTING ANIMAL MODELS AND 

1831
01:34:27,000 --> 01:34:28,560
WANT TO KNOW WHAT WE'RE 

1832
01:34:28,560 --> 01:34:29,680
MODELLING AND WHAT HAPPENS TO 

1833
01:34:29,680 --> 01:34:32,480
HUMANS IN THE LONG HAUL.

1834
01:34:32,480 --> 01:34:35,360
IT WAS A VERY ENGAGING 

1835
01:34:35,360 --> 01:34:38,040
DISCUSSION, ONCE AGAIN, AND 

1836
01:34:38,040 --> 01:34:39,800
LOOKING FORWARD A FEW OTHER 

1837
01:34:39,800 --> 01:34:42,360
ITERATIONS IN WHICH WE BROADLY, 

1838
01:34:42,360 --> 01:34:47,840
THE COMMUNITY HAVE INPUT INTO 

1839
01:34:47,840 --> 01:34:48,680
THIS PROCESS.

1840
01:34:48,680 --> 01:34:52,280
AND SO I WOULD THINK OF VALUE 

1841
01:34:52,280 --> 01:34:55,080
ADD THE AREAS BEING WELL DEFINED

1842
01:34:55,080 --> 01:34:56,440
AND AS WE THINK ABOUT THEM IN 

1843
01:34:56,440 --> 01:34:58,200
THE FUTURE WE WANT TO BROADEN 

1844
01:34:58,200 --> 01:35:00,560
THEM AS MUCH AS POSSIBLE.

1845
01:35:00,560 --> 01:35:05,600
THAT'S MY TAKE.

1846
01:35:05,600 --> 01:35:09,520
I WAS WE PLEASED BY THE WHOLE 

1847
01:35:09,520 --> 01:35:10,640
EFFORT.

1848
01:35:10,640 --> 01:35:20,880
CONGRATULATIONS, PROGRAM STAFF.

1849
01:35:20,880 --> 01:35:21,320
>> THANK YOU.

1850
01:35:21,320 --> 01:35:26,280
I'LL MOVE FORWARD TO WHERE WE'RE

1851
01:35:26,280 --> 01:35:26,840
GOING NEXT.

1852
01:35:26,840 --> 01:35:30,240
IN MARCH OUR STAFF IS GOING TO 

1853
01:35:30,240 --> 01:35:33,280
BEGIN FINALIZING OUR LIST OF TOP

1854
01:35:33,280 --> 01:35:34,840
PRIORITIES BECAUSE EVEN THOUGH 

1855
01:35:34,840 --> 01:35:38,200
WE HAVE GREAT IDEAS, WE CAN'T DO

1856
01:35:38,200 --> 01:35:40,480
EVERYTHING ALL AT ONCE TO MAKE 

1857
01:35:40,480 --> 01:35:41,840
THE STRATEGIC PLAN ACTUALLY 

1858
01:35:41,840 --> 01:35:42,920
STRATEGIC AND USEFUL FOR THE 

1859
01:35:42,920 --> 01:35:44,440
INSTITUTE WE NEED TO IDENTIFY 

1860
01:35:44,440 --> 01:35:47,720
OUR TOP PRIORITIES FOR NOW.

1861
01:35:47,720 --> 01:35:50,200
ONCE WE FINALIZE OUR TOP 

1862
01:35:50,200 --> 01:35:51,280
PRIORITIES WE'LL DEVELOP THE 

1863
01:35:51,280 --> 01:35:52,600
FIRST DRAFT OF OUR STRATEGIC 

1864
01:35:52,600 --> 01:35:54,600
PLAN AND GET THAT READY TO POST 

1865
01:35:54,600 --> 01:35:59,600
FOR PUBLIC COMMENT IN MAY OF 

1866
01:35:59,600 --> 01:35:59,880
2021.

1867
01:35:59,880 --> 01:36:02,440
THAT WILL BE ANOTHER OPPORTUNITY

1868
01:36:02,440 --> 01:36:04,600
FOR THE PUBLIC AND OF COURSE 

1869
01:36:04,600 --> 01:36:06,600
COUNCIL TO COMMENT ON THE DRAFT 

1870
01:36:06,600 --> 01:36:17,920
PLAN TO GIVE US YOUR FEEDBACK.

1871
01:36:17,920 --> 01:36:19,640
TO GIVE YOU MORE DETAILS WE'LL 

1872
01:36:19,640 --> 01:36:21,120
NARROW DOWN THE LIST OF TOP 

1873
01:36:21,120 --> 01:36:23,040
IDEAS AND IDEAS ARE NOT ALWAYS 

1874
01:36:23,040 --> 01:36:25,360
GREAT AS STRATEGIC GOALS SO 

1875
01:36:25,360 --> 01:36:26,760
WE'RE GOING TAKE THOSE GREAT 

1876
01:36:26,760 --> 01:36:28,760
IDEAS AND DEVELOP THEM INTO 

1877
01:36:28,760 --> 01:36:30,600
STRATEGIC GOALS THAT ARE 

1878
01:36:30,600 --> 01:36:32,000
APPROPRIATE FOR A STRATEGIC 

1879
01:36:32,000 --> 01:36:32,520
PLAN.

1880
01:36:32,520 --> 01:36:34,720
THEN WE'RE GOING TO BE GROUPING 

1881
01:36:34,720 --> 01:36:35,720
SIMILAR IDEAS INTO THEMES TO 

1882
01:36:35,720 --> 01:36:38,040
HAVE A WAY TO TALK ABOUT WHAT 

1883
01:36:38,040 --> 01:36:40,840
WE'RE DOING AND IDENTIFY THEMES 

1884
01:36:40,840 --> 01:36:42,640
FOR MESSAGING ABOUT OUR 

1885
01:36:42,640 --> 01:36:43,440
STRATEGIC PLAN.

1886
01:36:43,440 --> 01:36:46,640
AND WE'RE ALSO GOING TO BE THIS 

1887
01:36:46,640 --> 01:36:49,600
WHOLE TIME LOOKING FOR GAP 

1888
01:36:49,600 --> 01:36:49,800
AREAS.

1889
01:36:49,800 --> 01:36:51,560
AREAS WHERE WE BELIEVE THERE'S 

1890
01:36:51,560 --> 01:36:53,160
AN OPPORTUNITY TO MOVE FORWARD.

1891
01:36:53,160 --> 01:36:53,720
SOMETHING THAT SHOULD BE 

1892
01:36:53,720 --> 01:36:57,040
ADDRESSED WHERE WE DON'T HAVE 

1893
01:36:57,040 --> 01:36:58,360
ANYTHING YET INCLUDED IN THE 

1894
01:36:58,360 --> 01:36:59,760
PLAN AND IDENTIFY THE GAP AREAS.

1895
01:36:59,760 --> 01:37:04,760
AS I SAID, FINALLY, POST THE 

1896
01:37:04,760 --> 01:37:05,600
DRAFT PLAN.

1897
01:37:05,600 --> 01:37:07,040
WE HOPE THE COUNCIL WILL REVIEW 

1898
01:37:07,040 --> 01:37:08,320
THE DRAFT PLAN WHEN WE POST IT 

1899
01:37:08,320 --> 01:37:11,320
AND WELCOME INPUT FROM THE 

1900
01:37:11,320 --> 01:37:12,920
COUNCIL ON THE DRAFT PLAN AND 

1901
01:37:12,920 --> 01:37:19,480
ABOUT GAP AREAS AS WELL.

1902
01:37:19,480 --> 01:37:21,080
FINALLY, WE WELCOME QUESTIONS.

1903
01:37:21,080 --> 01:37:24,640
WE WELCOME YOU TO ASK QUESTIONS 

1904
01:37:24,640 --> 01:37:26,360
NOW AT THIS SESSION OR YOU CAN 

1905
01:37:26,360 --> 01:37:30,320
SEND THEM TO ME OR TO DAN AND 

1906
01:37:30,320 --> 01:37:30,720
NIRUPA.

1907
01:37:30,720 --> 01:37:34,040
OUR CONTACT INFORMATION IS ON 

1908
01:37:34,040 --> 01:37:36,000
THE SLIDE AS WELL AS AN NIDCD 

1909
01:37:36,000 --> 01:37:37,520
STRATEGIC PLAN MAILBOX.

1910
01:37:37,520 --> 01:37:48,760
WE MONITOR THAT AS WELL.

1911
01:37:48,760 --> 01:37:52,480
I GUESS NOW I'LL WELCOME ANY 

1912
01:37:52,480 --> 01:37:54,040
COMMENTS PEOPLE HAVE ON THE 

1913
01:37:54,040 --> 01:37:55,040
STRATEGIC PLAN.

1914
01:37:55,040 --> 01:38:01,920
>> I WANT TO CONNECTICGRATULATE
YOU 

1915
01:38:01,920 --> 01:38:04,480
AND THE STAFF AND WE WORRIED 

1916
01:38:04,480 --> 01:38:05,480
WHEN IT WAS VIRTUAL IT WOULDN'T 

1917
01:38:05,480 --> 01:38:08,440
BE AS DYNAMIC AND ENGAGING BUT 

1918
01:38:08,440 --> 01:38:10,320
THE SESSIONS I LISTENED TO WERE 

1919
01:38:10,320 --> 01:38:16,120
VERY ENGAGING AND EXCITING.

1920
01:38:16,120 --> 01:38:22,680
I THINK YOU ACHIEVED THE GOALS 

1921
01:38:22,680 --> 01:38:23,200
WE WERE AFTER.

1922
01:38:23,200 --> 01:38:24,800
ANY DISCUSSION OR QUESTIONS?

1923
01:38:24,800 --> 01:38:26,080
WE'D LOVE TO HEAR YOUR THOUGHTS 

1924
01:38:26,080 --> 01:38:43,520
ON THIS.

1925
01:38:43,520 --> 01:38:45,440
>> IT SOUNDS LIKE YOU'VE DONE A 

1926
01:38:45,440 --> 01:38:52,200
GREAT JOB AT GETTING THE MOST 

1927
01:38:52,200 --> 01:38:56,040
IMPACTFUL THOUGHTS ELICITED AND 

1928
01:38:56,040 --> 01:38:57,440
CONGRATULATIONS ON PULLING OFF 

1929
01:38:57,440 --> 01:39:00,240
IN A CHALLENGING ENVIRONMENT 

1930
01:39:00,240 --> 01:39:01,920
LIKE THE REMOTE ENVIRONMENT.

1931
01:39:01,920 --> 01:39:05,200
>> THANK YOU FOR THAT.

1932
01:39:05,200 --> 01:39:09,040
THANKS ALSO, DR. TUCCI ABOUT THE

1933
01:39:09,040 --> 01:39:10,040
PROCESS.

1934
01:39:10,040 --> 01:39:11,440
WE'RE LOOKING FORWARD TO SEEING 

1935
01:39:11,440 --> 01:39:12,440
WHAT WE CAN DO WITH THESE GREAT 

1936
01:39:12,440 --> 01:39:25,800
IDEAS.

1937
01:39:25,800 --> 01:39:28,520
>> IN YOU SAY MORE ABOUT THE 

1938
01:39:28,520 --> 01:39:30,200
TIME LINE AND WHEN WE'LL SEE THE

1939
01:39:30,200 --> 01:39:33,160
PRODUCT IN COUNCIL AND ISSUE FOR

1940
01:39:33,160 --> 01:39:33,280
?

1941
01:39:33,280 --> 01:39:36,640
>> OUR GOAL IS TO GET THINGS 

1942
01:39:36,640 --> 01:39:37,760
NARROWED DOWN TO IDENTIFY THE 

1943
01:39:37,760 --> 01:39:40,560
TOP PRIORITIES AND WORK ON A 

1944
01:39:40,560 --> 01:39:44,560
DRAFT THAT WE CAN POSE FOR 

1945
01:39:44,560 --> 01:39:46,560
PUBLIC COMMENT FOR A 30-DAY 

1946
01:39:46,560 --> 01:39:48,280
PERIOD IN MAY AND WE HOPE THAT 

1947
01:39:48,280 --> 01:39:49,840
WE WILL BE ABLE TO TELL YOU 

1948
01:39:49,840 --> 01:39:52,520
WHERE WE ARE WITH THAT PROCESS 

1949
01:39:52,520 --> 01:39:56,880
AT THE NEXT COUNCIL MEETING AND 

1950
01:39:56,880 --> 01:39:58,160
SINCE WE'RE TRYING TO KEEP 

1951
01:39:58,160 --> 01:39:59,040
COUNCIL INVOLVED IN THIS 

1952
01:39:59,040 --> 01:40:04,360
PROCESS, WE WELCOME YOUR 

1953
01:40:04,360 --> 01:40:12,920
FEEDBACK AT ANY TIME ABOUT WHAT 

1954
01:40:12,920 --> 01:40:14,240
YOU HEARD AND ENCOURAGE FOR 

1955
01:40:14,240 --> 01:40:15,800
COMMENT ON THE DRAFT PLAN.

1956
01:40:15,800 --> 01:40:19,040
WE'LL BE LISTING IT AND WE'LL 

1957
01:40:19,040 --> 01:40:20,480
HAVE A REQUEST FOR INFORMATION.

1958
01:40:20,480 --> 01:40:23,560
WE WILL HAVE A WEBSITE AND WE 

1959
01:40:23,560 --> 01:40:25,040
WILL WELCOME ALL THE FEEDBACK 

1960
01:40:25,040 --> 01:40:27,160
FROM THE PUBLIC THAT WAY.

1961
01:40:27,160 --> 01:40:30,880
DID THAT ANSWER YOUR QUESTION?

1962
01:40:30,880 --> 01:40:33,000
>> YEP, VERY GOOD.

1963
01:40:33,000 --> 01:40:34,840
SO THE GOAL IS TO HAVE A FINAL 

1964
01:40:34,840 --> 01:40:35,800
PRODUCT BY THE END OF THE YEAR.

1965
01:40:35,800 --> 01:40:41,560
>> THAT'S THE DEAL.

1966
01:40:41,560 --> 01:40:44,040
-- THE GOAL.

1967
01:40:44,040 --> 01:40:44,960
I'M NOT SEEING A LOT OF 

1968
01:40:44,960 --> 01:40:45,960
QUESTIONS SO THANK YOU FOR THE 

1969
01:40:45,960 --> 01:40:48,080
TIME TO PRESENT AND THANKS FOR 

1970
01:40:48,080 --> 01:40:51,040
DAN AND NIRUPA FOR SHARING THEIR

1971
01:40:51,040 --> 01:40:52,360
PERSPECTIVE AND FEEL FREE TO 

1972
01:40:52,360 --> 01:40:53,600
FOLLOW-UP WITH AN E-MAIL IF YOU 

1973
01:40:53,600 --> 01:40:55,520
HAVE QUESTIONS.

1974
01:40:55,520 --> 01:41:05,160
THANK YOU.

1975
01:41:05,160 --> 01:41:07,880
>> THANK YOU, LAURA AND NIRUPA 

1976
01:41:07,880 --> 01:41:09,280
AND DAN.

1977
01:41:09,280 --> 01:41:11,440
NEXT WE HAVE DR. MARIE BERNARD 

1978
01:41:11,440 --> 01:41:12,400
AND WE'RE RUNNING A LITTLE BIT 

1979
01:41:12,400 --> 01:41:13,680
OF AHEAD OF SCHEDULE.

1980
01:41:13,680 --> 01:41:17,080
DO YOU KNOW IF DR. BERNARD IS ON

1981
01:41:17,080 --> 01:41:18,640
>> SHE'S HERE.

1982
01:41:18,640 --> 01:41:23,040
>> OH, GOOD, FANTASTIC.

1983
01:41:23,040 --> 01:41:27,440
MARIE, I'LL GIVE A BRIEF 

1984
01:41:27,440 --> 01:41:28,040
INTRODUCTION.

1985
01:41:28,040 --> 01:41:30,640
WE APPRECIATE YOU BEING HERE AND

1986
01:41:30,640 --> 01:41:33,320
SERVES AS THE CHIEF OFFICER FOR 

1987
01:41:33,320 --> 01:41:34,320
SCIENTIFIC WORKFORCE DIFFERENCE 

1988
01:41:34,320 --> 01:41:36,640
TI AND LEADS THE NIH'S EFFORTS 

1989
01:41:36,640 --> 01:41:39,560
TO PROMOTE DIVERSITY, 

1990
01:41:39,560 --> 01:41:41,080
INCLUSIVENESS AND EQUITY 

1991
01:41:41,080 --> 01:41:42,680
THROUGHOUT THE BIOMEDICAL 

1992
01:41:42,680 --> 01:41:44,280
RESEARCH ENTERPRISE.

1993
01:41:44,280 --> 01:41:45,840
DR. BERNARD WAS PREVIOUSLY AS 

1994
01:41:45,840 --> 01:41:48,960
DR. HODES MENTIONED THE DEPUTY 

1995
01:41:48,960 --> 01:41:51,640
DIRECTOR OF THE NATIONAL 

1996
01:41:51,640 --> 01:41:55,040
INSTITUTE ON AGING FROM 2008 TO 

1997
01:41:55,040 --> 01:41:57,360
2021 AND SHE'S BEEN INVOLVED IN 

1998
01:41:57,360 --> 01:42:01,080
A WIDE VARIETY OF NIH ACTIVITIES

1999
01:42:01,080 --> 01:42:03,600
TO FURTHER DIVERSITY.

2000
01:42:03,600 --> 01:42:04,880
DR. BERNARD HAS BEEN RECOGNIZED 

2001
01:42:04,880 --> 01:42:08,760
WITH MULTIPLE AWARDS FOR HER 

2002
01:42:08,760 --> 01:42:10,200
LEADERSHIP INCLUDING THE 2020 

2003
01:42:10,200 --> 01:42:13,440
NIH DIRECTOR'S AWARD FOR EQUITY,

2004
01:42:13,440 --> 01:42:15,040
DIVERSITY AND INCLUSION AND SHE 

2005
01:42:15,040 --> 01:42:18,720
HAS AGREED TO PROVIDE AN UPDATE 

2006
01:42:18,720 --> 01:42:21,520
ON THE NIH'S UNITE INITIATIVE 

2007
01:42:21,520 --> 01:42:23,560
PARTICULARLY ON WHAT WILL BE 

2008
01:42:23,560 --> 01:42:24,400
DONE IN THE NEXT YEAR.

2009
01:42:24,400 --> 01:42:25,640
YOU'VE HEARD ME TALK ABOUT THIS 

2010
01:42:25,640 --> 01:42:28,200
FOR THE LAST COUPLE OF COUNCIL 

2011
01:42:28,200 --> 01:42:31,400
MEETINGS AND DR. BERNARD IS ONE 

2012
01:42:31,400 --> 01:42:36,040
OF THE LEADS ACROSS THE NIH FOR 

2013
01:42:36,040 --> 01:42:38,040
THE PROGRAM.

2014
01:42:38,040 --> 01:42:39,040
I'M GRATEFUL TO YOU FOR COMING 

2015
01:42:39,040 --> 01:42:53,360
AND TALKING ABOUT THIS TODAY.

2016
01:42:53,360 --> 01:42:56,200
>> I'M HAPPY TO TALK ABOUT THE 

2017
01:42:56,200 --> 01:42:59,680
UNITE INITIATIVE APPROACHING THE

2018
01:42:59,680 --> 01:43:01,080
ONE-YEAR UNIVERSITY FOR BEING 

2019
01:43:01,080 --> 01:43:01,520
PUBLICLY UNVEILED.

2020
01:43:01,520 --> 01:43:03,360
YOU HEARD ABOUT IT BUT TO RECAP,

2021
01:43:03,360 --> 01:43:06,920
IT WAS DRIVEN BY THE EVENTS OF 

2022
01:43:06,920 --> 01:43:11,360
2020 WHERE WE SAW MORBIDITY AND 

2023
01:43:11,360 --> 01:43:13,640
MORTALITY FOR ETHNIC AND RACIAL 

2024
01:43:13,640 --> 01:43:16,480
MINORITIES IN OUR COUNTRY DUE TO

2025
01:43:16,480 --> 01:43:17,440
THE COVID PANDEMIC.

2026
01:43:17,440 --> 01:43:30,000
WE SAW ESCALATING VIOLENCE AND 

2027
01:43:30,000 --> 01:43:35,800
BEFORE THE ACCENTUATION OF THE 

2028
01:43:35,800 --> 01:43:39,160
KILLING OF SIX ASIAN WOMEN IN 

2029
01:43:39,160 --> 01:43:39,600
ATLANTA.

2030
01:43:39,600 --> 01:43:43,120
THIS BROUGHT INTO LIGHT THE 

2031
01:43:43,120 --> 01:43:44,600
RACIAL AND ETHNICIN JUSTICE IN 

2032
01:43:44,600 --> 01:43:45,880
OUR COUNTRY AND THE 

2033
01:43:45,880 --> 01:43:47,040
RESPONSIBILITY WE ALL HAVE TO 

2034
01:43:47,040 --> 01:43:49,640
ADDRESS THE ISSUE.

2035
01:43:49,640 --> 01:43:55,200
THAT WAS A BROAD CONSENSUS AT 

2036
01:43:55,200 --> 01:43:57,080
THE NIH WE WERE AT A TIPPING 

2037
01:43:57,080 --> 01:43:58,840
POINT AND IT WAS TIME TO PAY 

2038
01:43:58,840 --> 01:43:59,720
ATTENTION TO THIS UNDER 

2039
01:43:59,720 --> 01:44:00,840
SUPPORTED AREA.

2040
01:44:00,840 --> 01:44:02,840
WE DEVELOPED A SHARED COMMITMENT

2041
01:44:02,840 --> 01:44:09,160
TO ADDRESS STRUCTURAL RACISM IN 

2042
01:44:09,160 --> 01:44:10,960
THE BIOMEDICAL RESEARCH 

2043
01:44:10,960 --> 01:44:12,520
ENTERPRISE AND AFTER LOTS OF 

2044
01:44:12,520 --> 01:44:14,840
INTERNAL WORK WE WERE LAUNCHED 

2045
01:44:14,840 --> 01:44:18,640
IN FEBRUARY 2020 AND ANNOUNCED 

2046
01:44:18,640 --> 01:44:20,440
THE NIH UNITE INITIATIVE WITH 

2047
01:44:20,440 --> 01:44:21,600
UNITE REPRESENTS FIVE 

2048
01:44:21,600 --> 01:44:23,000
INTERACTING WORK STREAMS.

2049
01:44:23,000 --> 01:44:24,720
ONE TO UNDERSTAND STAKEHOLDER 

2050
01:44:24,720 --> 01:44:27,600
EXPERIENCES THROUGH LISTENING 

2051
01:44:27,600 --> 01:44:28,400
AND LEARNING.

2052
01:44:28,400 --> 01:44:31,200
YOU MAY RECALL AN RFI ISSUED.

2053
01:44:31,200 --> 01:44:34,760
THIS WAS ANNOUNCED FEBRUARY 26, 

2054
01:44:34,760 --> 01:44:37,760
FRIDAY FEBRUARY 26 AND IT WAS 

2055
01:44:37,760 --> 01:44:39,040
RELEASED MONDAY MARCH 1.

2056
01:44:39,040 --> 01:44:40,000
HOPEFULLY MANY HAD A CHANCE TO 

2057
01:44:40,000 --> 01:44:42,880
RESPOND TO THAT.

2058
01:44:42,880 --> 01:44:45,640
WE SAID WE'D LOOK AT NEW ON 

2059
01:44:45,640 --> 01:44:47,200
HEALTH DISPARITIES, MINORITY 

2060
01:44:47,200 --> 01:44:48,160
HEALTH AND HEALTH EQUITY AND 

2061
01:44:48,160 --> 01:44:51,400
LOOK AT IMPROVING THE INTERNAL 

2062
01:44:51,400 --> 01:44:52,560
NIH CULTURE AND STRUCTURE FOR 

2063
01:44:52,560 --> 01:44:54,440
EQUITY AND INCLUSION AND 

2064
01:44:54,440 --> 01:44:56,160
EXCELLENCE WITH THE THEORY WE 

2065
01:44:56,160 --> 01:45:02,320
NEEDED TO GET OUR OWN HOUSE IN 

2066
01:45:02,320 --> 01:45:04,400
ORDER AND ROLE MODEL WE HOPE 

2067
01:45:04,400 --> 01:45:06,120
WILL OCCUR IN THE ECO SYSTEM AND

2068
01:45:06,120 --> 01:45:08,120
HOLD OURSELVES TO BE TRANSPARENT

2069
01:45:08,120 --> 01:45:09,440
AND COMMUNICATE AND BE 

2070
01:45:09,440 --> 01:45:12,560
ACCOUNTABLE AND GOING TO BE 

2071
01:45:12,560 --> 01:45:13,120
LOOKING AT THE EXTRAMURAL 

2072
01:45:13,120 --> 01:45:15,960
RESEARCH ECO SYSTEM AND WHAT 

2073
01:45:15,960 --> 01:45:17,760
STRUCTURAL CHANGES ARE NEEDED TO

2074
01:45:17,760 --> 01:45:20,240
PROMOTE WORKFORCE DIVERSITY.

2075
01:45:20,240 --> 01:45:23,320
ANOTHER WAY OF LOOKING AT THE 

2076
01:45:23,320 --> 01:45:25,440
LOCI OF UNITE ILLUSTRATED HERE 

2077
01:45:25,440 --> 01:45:27,600
COMES FROM A NATURE MEDICINE 

2078
01:45:27,600 --> 01:45:36,840
COMMENTARY THAT LARRY TABAK AND 

2079
01:45:36,840 --> 01:45:40,960
I AND OTHERS PUBLISHED IN 

2080
01:45:40,960 --> 01:45:43,360
RESEARCH FOCUSSING ON THE 

2081
01:45:43,360 --> 01:45:45,000
INTERNAL WORKFORCE AND I'LL TALK

2082
01:45:45,000 --> 01:45:46,800
TO YOU ABOUT HIGHLIGHTS IN EACH 

2083
01:45:46,800 --> 01:45:48,440
OF THE AREAS AND THINGS TO LOOK 

2084
01:45:48,440 --> 01:45:50,040
FORWARD TO.

2085
01:45:50,040 --> 01:45:53,600
FROM THE STANDPOINT OF THE 

2086
01:45:53,600 --> 01:45:54,960
HEALTH DISPARITIES RESEARCH 

2087
01:45:54,960 --> 01:46:00,800
REALM WE SAID WE'D DO A COMMON 

2088
01:46:00,800 --> 01:46:03,760
FUND INITIATIVE ON ADDRESSING 

2089
01:46:03,760 --> 01:46:07,400
HEALTH DISPARITIES AND 

2090
01:46:07,400 --> 01:46:10,520
MULTIMILLIONS OF DOLLARS AND THE

2091
01:46:10,520 --> 01:46:14,840
FOA WAS RELEASED AND 11 AWARDS 

2092
01:46:14,840 --> 01:46:15,800
ANNOUNCED.

2093
01:46:15,800 --> 01:46:17,400
THERE ARE SIX LOOKING AT 

2094
01:46:17,400 --> 01:46:21,360
RESEARCH TO ADDRESS HEALTH 

2095
01:46:21,360 --> 01:46:23,320
DISPARITIES AND IMPROVE HEALTH 

2096
01:46:23,320 --> 01:46:26,040
IN GENERAL AND LOOK AT MINORITY 

2097
01:46:26,040 --> 01:46:30,400
SERVING INSTITUTIONS AND AN 

2098
01:46:30,400 --> 01:46:34,040
ADDITIONAL COMPETITION FOR 

2099
01:46:34,040 --> 01:46:35,400
MINORITY SERVING INSTITUTIONS.

2100
01:46:35,400 --> 01:46:39,280
WE'RE LOOKING AT DATA SHOWING 

2101
01:46:39,280 --> 01:46:42,920
THAT LIFE EXPECTANCY HAS GONE 

2102
01:46:42,920 --> 01:46:44,840
DOWN WITH THE COVID PANDEMIC.

2103
01:46:44,840 --> 01:46:47,760
THERE'S ALWAYS BEEN 

2104
01:46:47,760 --> 01:46:48,080
DISCREPANCIES.

2105
01:46:48,080 --> 01:46:50,480
HERE'S THE TOTAL POSSIBLE LIFE 

2106
01:46:50,480 --> 01:46:53,600
EXPECTANCY ON NON-HISPANIC 

2107
01:46:53,600 --> 01:46:55,000
WHITES, BLACKS, LATINOS.

2108
01:46:55,000 --> 01:46:58,040
THIS IS KNOWN AS THE LATINO 

2109
01:46:58,040 --> 01:47:02,200
PARADOX IN SPITE OF HIGH 

2110
01:47:02,200 --> 01:47:03,200
PREVALENCE OF DIABETES LATINOS 

2111
01:47:03,200 --> 01:47:05,440
HAVE A LONGER LIFE EXPECTANCY 

2112
01:47:05,440 --> 01:47:07,320
AND YET EVERYONE HAD THEIR LIFE 

2113
01:47:07,320 --> 01:47:09,440
EXPECTANCY GO DOWN WITH THE 

2114
01:47:09,440 --> 01:47:11,040
PANDEMIC AND MORE DRAMATICALLY 

2115
01:47:11,040 --> 01:47:13,560
WITH THE LATINOS WITH THE 

2116
01:47:13,560 --> 01:47:13,840
PANDEMIC.

2117
01:47:13,840 --> 01:47:16,000
WE'RE VERY CONCERNED ABOUT THIS 

2118
01:47:16,000 --> 01:47:17,360
AND SOME THINGS BEING DONE TO 

2119
01:47:17,360 --> 01:47:18,800
ADDRESS IT IS WE'RE WORKING HARD

2120
01:47:18,800 --> 01:47:24,760
ON BEING MORE ACCOUNTABLE AND 

2121
01:47:24,760 --> 01:47:29,280
TRANSPARENT AND ACCURATE AIN 

2122
01:47:29,280 --> 01:47:30,600
CATALOGING WHAT WE SEE IN HEALTH

2123
01:47:30,600 --> 01:47:33,160
DISPARITY RESEARCH AND WORK ON A

2124
01:47:33,160 --> 01:47:35,600
COMMON FUND INITIATIVE FOR 

2125
01:47:35,600 --> 01:47:38,600
FISCAL YEAR '23 TO TRY TO 

2126
01:47:38,600 --> 01:47:39,720
ADDRESS SOME ISSUES.

2127
01:47:39,720 --> 01:47:41,400
IN TERMS OF WHAT WE'RE DOING AND

2128
01:47:41,400 --> 01:47:43,680
HAVE DONE WITH REGARDS TO 

2129
01:47:43,680 --> 01:47:45,640
INTERNAL WORKFORCE, WE FOR THIS 

2130
01:47:45,640 --> 01:47:48,920
FISCAL YEAR '22 BEGINNING 

2131
01:47:48,920 --> 01:47:53,440
OCTOBER 1 NOW HAVE A PERFORMANCE

2132
01:47:53,440 --> 01:47:57,200
METRIC AND PERFORMANCE 

2133
01:47:57,200 --> 01:47:59,520
EXPECTATION FOR DIRECTORS AS 

2134
01:47:59,520 --> 01:48:01,640
THEY LEAD PEOPLE TAKE INTO 

2135
01:48:01,640 --> 01:48:02,920
CONSIDERATION DIVERSITY, EQUITY 

2136
01:48:02,920 --> 01:48:06,320
AND INCLUSION AND ACCESSIBILITY.

2137
01:48:06,320 --> 01:48:07,320
THERE ARE REQUIREMENTS FROM THE 

2138
01:48:07,320 --> 01:48:09,200
DEPARTMENT OF HEALTH AND HUMAN 

2139
01:48:09,200 --> 01:48:10,360
SERVICES AND THE NIH 

2140
01:48:10,360 --> 01:48:12,160
REQUIREMENTS ARE MORE EXTENSIVE.

2141
01:48:12,160 --> 01:48:14,760
THERE'S AT LEAST FOUR COMPONENT 

2142
01:48:14,760 --> 01:48:19,120
TO THAT AND EYE COMPONE -- A
COMPONENT 

2143
01:48:19,120 --> 01:48:21,000
IS THE RACIAL AND ETHNIC AND 

2144
01:48:21,000 --> 01:48:21,720
EQUITY PLANS FOR THE 27 

2145
01:48:21,720 --> 01:48:23,360
INSTITUTES AND CENTERS.

2146
01:48:23,360 --> 01:48:25,400
THIS IS MODELS AFTER WHAT WAS 

2147
01:48:25,400 --> 01:48:29,240
DONE IN THE ANTI-HARASSMENT 

2148
01:48:29,240 --> 01:48:32,040
EFFORTS IN 2018 WHERE THERE WAS 

2149
01:48:32,040 --> 01:48:34,440
AN ANTI-HARASSMENT PLAN AND 

2150
01:48:34,440 --> 01:48:36,640
THEY'LL BE CUSTOMIZED TO THE 

2151
01:48:36,640 --> 01:48:39,160
I.C.s CULTURE AND CIRCUMSTANCES 

2152
01:48:39,160 --> 01:48:44,160
SO THEY'LL BE FLEXIBLE AND 

2153
01:48:44,160 --> 01:48:45,960
VARIABILITY AMONG INSTITUTES AND

2154
01:48:45,960 --> 01:48:48,640
CENTERS AND DESIGNED TO BE 

2155
01:48:48,640 --> 01:48:51,400
ACCOUNTABLE WITH LONG TERM AND 

2156
01:48:51,400 --> 01:48:55,360
SHORT TERM MEASURES AND THERE'LL

2157
01:48:55,360 --> 01:48:56,880
BE A LOT OF ANALYSIS AND SHARING

2158
01:48:56,880 --> 01:49:00,240
OF KNOWLEDGE AMONG THE I.C.s.

2159
01:49:00,240 --> 01:49:06,200
IT REQUIRED A LOT OF INVESTMENT,

2160
01:49:06,200 --> 01:49:08,040
INTELLECTUAL CAPITAL AND TIME 

2161
01:49:08,040 --> 01:49:08,880
AND FUNDS.

2162
01:49:08,880 --> 01:49:10,600
PEOPLE WILL ASSESS, DESIGN, 

2163
01:49:10,600 --> 01:49:13,720
IMPLEMENT, REPORT AND THEN GO 

2164
01:49:13,720 --> 01:49:14,320
BACK FURTHER FOR CONTINUED 

2165
01:49:14,320 --> 01:49:22,440
IMPROVEMENTS.

2166
01:49:22,440 --> 01:49:22,920
THIS WAS UNMAILED FOREVER 

2167
01:49:28,800 --> 01:49:33,760
-- NOVEMBER 4 AND THEY WERE TO 

2168
01:49:33,760 --> 01:49:37,480
DESIGN AND TURN IT INTO THE 

2169
01:49:37,480 --> 01:49:39,200
REVIEWER DURING THE MONTH OF 

2170
01:49:39,200 --> 01:49:42,040
APRIL AND ONCE APPROVED, EVERY 

2171
01:49:42,040 --> 01:49:44,160
INSTITUTE AND CENTER IS EXPECTED

2172
01:49:44,160 --> 01:49:50,760
TO BEGIN THE IMPLEMENTATION WITH

2173
01:49:50,760 --> 01:49:51,680
THE EXPECTATION THEY'LL REPORT 

2174
01:49:51,680 --> 01:49:52,680
ON WHAT THEY ACCOMPLISH AND 

2175
01:49:52,680 --> 01:49:54,640
THINKING ABOUT WHAT THEY WANT TO

2176
01:49:54,640 --> 01:49:58,800
DO FOR THE COMING FISCAL YEAR 

2177
01:49:58,800 --> 01:50:01,440
WITH REGARD.

2178
01:50:01,440 --> 01:50:08,560
ANOTHER THING WE'RE TRYING TO DO

2179
01:50:08,560 --> 01:50:10,480
INTERNALLY IS THE POWER OF THE 

2180
01:50:10,480 --> 01:50:12,120
WORKFORCE RECOGNITION PROJECT.

2181
01:50:12,120 --> 01:50:14,640
THIS WAS LAUNCHED BY MEMBERS OF 

2182
01:50:14,640 --> 01:50:16,520
THE UNIT COMMITTEE THAT MADE THE

2183
01:50:16,520 --> 01:50:18,520
POINT WHAT YOU SEE AROUND YOU 

2184
01:50:18,520 --> 01:50:22,960
INFLUENCES YOUR SENSE OF 

2185
01:50:22,960 --> 01:50:27,400
BELONGING AND THERE'S QUITE A 

2186
01:50:27,400 --> 01:50:29,600
BIT OF DIVERSITY AROUND NIH BUT 

2187
01:50:29,600 --> 01:50:32,760
PERHAPS NOT WELL REPRESENTED.

2188
01:50:32,760 --> 01:50:35,600
THESE ARE PICTURES AND YOU SEE 

2189
01:50:35,600 --> 01:50:37,240
ALL PAST NIH DIRECTORS.

2190
01:50:37,240 --> 01:50:38,800
ONE WOMAN DIRECTOR AND THE REST 

2191
01:50:38,800 --> 01:50:44,240
NON-HISPANIC WHITE MALES.

2192
01:50:44,240 --> 01:50:47,280
WHEN YOU GO TO THE CLINICAL 

2193
01:50:47,280 --> 01:50:48,920
CENTER THERE'S LITTLE DIVERSITY 

2194
01:50:48,920 --> 01:50:50,640
WITH THE EXCEPTION OF THIS 

2195
01:50:50,640 --> 01:50:51,800
DISPLAY PUT UP RECENTLY DURING 

2196
01:50:51,800 --> 01:50:57,280
THE COVID PANDEMIC.

2197
01:50:57,280 --> 01:51:01,640
THE INTENT IS TO CAPTURE THE 

2198
01:51:01,640 --> 01:51:04,200
WIDE RANGE OF PEOPLE WHO 

2199
01:51:04,200 --> 01:51:09,240
CONTRIBUTE TO THE SUCCESS OF THE

2200
01:51:09,240 --> 01:51:20,960
NIH RESEARCH ENTERPRISE.

2201
01:51:20,960 --> 01:51:22,480
YOU SEE WHAT IS REPRESENTED 

2202
01:51:22,480 --> 01:51:22,680
HERE.

2203
01:51:22,680 --> 01:51:25,040
THIS IS A PICTURE SHOWING THE 

2204
01:51:25,040 --> 01:51:30,440
WALK-THROUGH OF UNVEILING OF THE

2205
01:51:30,440 --> 01:51:32,240
INSTALLATION IN LATE NOVEMBER IN

2206
01:51:32,240 --> 01:51:34,760
THE CLINICAL CENTER BETWEEN THE 

2207
01:51:34,760 --> 01:51:35,840
SOUTH ENTRANCE AND THE LIBRARY.

2208
01:51:35,840 --> 01:51:38,240
AT SOME POINT WE'LL ALL BE ABLE 

2209
01:51:38,240 --> 01:51:43,560
TO GET BACK FIS PHYSICALLY AND 

2210
01:51:43,560 --> 01:51:46,520
YOU SEE DR. TABAK AND 

2211
01:51:46,520 --> 01:51:48,920
DR. JACKSON WHO LED THE TEAM TO 

2212
01:51:48,920 --> 01:51:54,080
DEVELOP ALL OF THIS.

2213
01:51:54,080 --> 01:52:06,400
DR. COLLINS AND THERE'S MORE IN 

2214
01:52:06,400 --> 01:52:09,760
THE CLINIC CENTER CAFETERIA AND 

2215
01:52:09,760 --> 01:52:13,800
BUILDING 1 WHERE THE OFFICES ARE

2216
01:52:13,800 --> 01:52:15,040
LOCATED AND INSULATION SHOWING 

2217
01:52:15,040 --> 01:52:21,280
THE CENTER DIRECTORS IN BUILDING

2218
01:52:21,280 --> 01:52:28,800
1 AND THEY'RE GREAT PLANS TO 

2219
01:52:28,800 --> 01:52:32,880
INCLUDE THIS FOR MULTIPLE 

2220
01:52:32,880 --> 01:52:37,720
CAMPUSES TRYING TO DEMONSTRATE 

2221
01:52:37,720 --> 01:52:42,040
FOR PEOPLE EVERYONE IS INCLUDED 

2222
01:52:42,040 --> 01:52:43,960
FOR PUSHING THE SCIENCE FORWARD.

2223
01:52:43,960 --> 01:52:46,440
YOU SEE FRANCIS COLLINS TAKING A

2224
01:52:46,440 --> 01:52:47,560
PICTURE TO SHARE WITH 

2225
01:52:47,560 --> 01:52:58,400
COLLEAGUES.

2226
01:52:58,400 --> 01:53:02,840
WE HAVE A PROGRAM UNVEILED IN 

2227
01:53:02,840 --> 01:53:04,840
DECEMBER 2020.

2228
01:53:04,840 --> 01:53:10,520
THE DISTINGUISHED SCHOLARS WAS 

2229
01:53:10,520 --> 01:53:12,880
DESIGNED TO DEVELOP 

2230
01:53:12,880 --> 01:53:16,480
SELF-REINFORCING COMMUNITIES OF 

2231
01:53:16,480 --> 01:53:18,560
PRINCIPLE INVESTIGATORS BUILT ON

2232
01:53:18,560 --> 01:53:20,000
THE PROGRAMS TO DO WHAT'S CALLED

2233
01:53:20,000 --> 01:53:22,160
COHORT RECRUITMENT, PEOPLE ARE 

2234
01:53:22,160 --> 01:53:23,680
BROUGHT IN AS GROUPS.

2235
01:53:23,680 --> 01:53:29,440
NOT JUST ONE-OFF SORTS OF HIRES.

2236
01:53:29,440 --> 01:53:33,080
THE THOUGHT WAS IF YOU CAN 

2237
01:53:33,080 --> 01:53:35,320
SELECT PEOPLE WITH DEMONSTRATED 

2238
01:53:35,320 --> 01:53:36,640
INTEREST AND TRACK RECORD IN 

2239
01:53:36,640 --> 01:53:38,800
DIVERSITY YOU FOSTER MORE 

2240
01:53:38,800 --> 01:53:39,760
DIVERSITY IN GENERAL AT 

2241
01:53:39,760 --> 01:53:40,880
INSTITUTES AND CENTERS THEY 

2242
01:53:40,880 --> 01:53:42,600
LEAD, ETCETERA.

2243
01:53:42,600 --> 01:53:44,040
IT'S BEEN IMPACTFUL.

2244
01:53:44,040 --> 01:53:45,440
WHAT WAS BEING SEEN PRIOR TO THE

2245
01:53:45,440 --> 01:53:50,040
START OF THE COHORT RECRUITMENT 

2246
01:53:50,040 --> 01:53:53,560
IS THE PERCENTAGE OF TENURE 

2247
01:53:53,560 --> 01:53:56,240
TRACK INVESTIGATORS WAS GOING 

2248
01:53:56,240 --> 01:53:57,480
PROGRESSIVELY DOWN AND THE 

2249
01:53:57,480 --> 01:53:59,640
PROGRAM WAS STARTED IN 2010 AND 

2250
01:53:59,640 --> 01:54:01,400
THE PERCENTAGES STARTED GOING UP

2251
01:54:01,400 --> 01:54:03,560
AND YOU ADD THE DISTINGUISHED 

2252
01:54:03,560 --> 01:54:05,560
SCHOLARS PROGRAM AND THERE'S AN 

2253
01:54:05,560 --> 01:54:13,160
INCREASE OR ACCELERATION IN THE 

2254
01:54:13,160 --> 01:54:17,040
RATE OF DIVERSIFICATION.

2255
01:54:17,040 --> 01:54:21,640
THE SCHOLARS AREN'T NECESSARILY 

2256
01:54:21,640 --> 01:54:23,280
SOMEONE FROM AN UNDER 

2257
01:54:23,280 --> 01:54:24,720
REPRESENTED GROUP AND LED TO 

2258
01:54:24,720 --> 01:54:27,160
CHANGES IN NUMBERS AND 

2259
01:54:27,160 --> 01:54:28,560
EVALUATING IN CHANGES AND IMPACT

2260
01:54:28,560 --> 01:54:30,840
AT THE INSTITUTES AND CENTERS.

2261
01:54:30,840 --> 01:54:36,320
THE DATA WERE SUFFICIENTLY 

2262
01:54:36,320 --> 01:54:47,160
IMPRESSIVE THAT EXTRAMURAL 

2263
01:54:47,160 --> 01:54:52,600
OPPORTUNITY WAS BASED ON WHAT'S 

2264
01:54:52,600 --> 01:54:54,240
HAPPENING WITH THE DISTINGUISHED

2265
01:54:54,240 --> 01:54:55,440
SCHOLARS PROGRAM AND CREATE 

2266
01:54:55,440 --> 01:54:57,520
CULTURES OF INCLUSIVE EXCELLENCE

2267
01:54:57,520 --> 01:55:00,440
AND GIVE FUNDS TO ACADEMIC 

2268
01:55:00,440 --> 01:55:04,680
INSTITUTIONS TO DO FACULTY 

2269
01:55:04,680 --> 01:55:08,280
COHORT HIRING AND DO MENTORING 

2270
01:55:08,280 --> 01:55:11,280
AND DEVELOPMENT AND LOOK AT THE 

2271
01:55:11,280 --> 01:55:13,240
INSTITUTION TO MAKE SURE THERE'S

2272
01:55:13,240 --> 01:55:15,520
NOT BIAS LOOK AT ENHANCING 

2273
01:55:15,520 --> 01:55:18,360
EQUITY AND MENTORING OR 

2274
01:55:18,360 --> 01:55:19,640
WORK/LIFE ISSUES AND OPPORTUNITY

2275
01:55:19,640 --> 01:55:22,760
FOR COMPETITION FOR A 

2276
01:55:22,760 --> 01:55:24,320
COORDINATING CENTER IN FISCAL 

2277
01:55:24,320 --> 01:55:26,160
YEAR '21.

2278
01:55:26,160 --> 01:55:29,000
OVERALL A COMMITMENT OF UP TO 

2279
01:55:29,000 --> 01:55:33,120
$241 MILLION FROM THE NIH COMMON

2280
01:55:33,120 --> 01:55:33,520
FUND.

2281
01:55:33,520 --> 01:55:35,440
THE FIRST COMPETITION YIELDED 

2282
01:55:35,440 --> 01:55:41,640
SIX COHORTS INVOLVING SEVEN 

2283
01:55:41,640 --> 01:55:42,640
INSTITUTIONS.

2284
01:55:42,640 --> 01:55:50,040
THIS IS A COLLABORATION THERE'S 

2285
01:55:50,040 --> 01:55:51,040
HIGH AND LOW RESOURCE 

2286
01:55:51,040 --> 01:55:51,840
INSTITUTIONS.

2287
01:55:51,840 --> 01:55:53,280
WE'RE EXCITE ABOUT THE FIRST 

2288
01:55:53,280 --> 01:55:53,520
COHORT.

2289
01:55:53,520 --> 01:55:55,600
THERE'S A COMPETITION FOR THE 

2290
01:55:55,600 --> 01:55:56,560
FISCAL YEAR.

2291
01:55:56,560 --> 01:55:59,320
THE APPLICATIONS ARE ALREADY IN.

2292
01:55:59,320 --> 01:56:00,200
THERE'LL BE AT LEAST ANOTHER 

2293
01:56:00,200 --> 01:56:02,240
FOUR OR MORE COHORTS ADDED AND 

2294
01:56:02,240 --> 01:56:04,200
SOON BE THE RELEASE OF AN FOA 

2295
01:56:04,200 --> 01:56:12,000
FOR A THIRD ROUND OF COMPETITION

2296
01:56:12,000 --> 01:56:14,960
WITH AT LEAST ANOTHER FOUR 

2297
01:56:14,960 --> 01:56:15,840
COHORTS INVOLVED AND MOREHOUSE 

2298
01:56:15,840 --> 01:56:21,640
SCHOOL OF MEDICINE WILL LOOK AT 

2299
01:56:21,640 --> 01:56:23,640
THE OUTCOMES AND GENERALIZABLE 

2300
01:56:23,640 --> 01:56:25,200
PRINCIPLES WE CAN CONSIDER FOR 

2301
01:56:25,200 --> 01:56:26,480
OTHER FUNDING OPPORTUNITY 

2302
01:56:26,480 --> 01:56:29,320
ANNOUNCEMENTS GOING FORWARD.

2303
01:56:29,320 --> 01:56:30,720
THERE'S A LOT OF THINGS THAT ARE

2304
01:56:30,720 --> 01:56:36,560
ON THE WAY THAT I WOULD 

2305
01:56:36,560 --> 01:56:40,000
ENCOURAGE YOU TO KEEP ON AS 

2306
01:56:40,000 --> 01:56:41,960
PUBLISHED AND THESE WERE 

2307
01:56:41,960 --> 01:56:43,000
DISCUSSED AT THE COMMITTEE TO 

2308
01:56:43,000 --> 01:56:51,480
THE DIRECTOR MEETING AND 

2309
01:56:51,480 --> 01:56:52,720
APPROVED AND THINGS LIKE GOING 

2310
01:56:52,720 --> 01:56:54,920
THROUGH THE PARTNERSHIP AWARDS 

2311
01:56:54,920 --> 01:56:55,160
PROGRAM.

2312
01:56:55,160 --> 01:56:56,480
IT'S BEEN LED BY THE NATIONAL 

2313
01:56:56,480 --> 01:56:59,960
INSTITUTE OF GENERAL MEDICAL 

2314
01:56:59,960 --> 01:57:02,800
SCIENCES THAT SUPPORTS K-12 

2315
01:57:02,800 --> 01:57:09,040
S.T.E.M. EDUCATION AND GIVEN WE 

2316
01:57:09,040 --> 01:57:17,440
KNOW THAT SCIENCE IDENTITY AS 

2317
01:57:17,440 --> 01:57:18,800
EARLY AS MIDDLE SCHOOL AND IT'S 

2318
01:57:18,800 --> 01:57:19,520
ONGOING.

2319
01:57:19,520 --> 01:57:21,240
THERE'S PLANS TO STRENGTHEN 

2320
01:57:21,240 --> 01:57:24,920
DIVERSITY AND MENTORING LANGUAGE

2321
01:57:24,920 --> 01:57:28,480
AND PARENT TRAINING GRANT AND 

2322
01:57:28,480 --> 01:57:29,320
FELLOWSHIP FOAs.

2323
01:57:29,320 --> 01:57:31,200
AND INCREASE THE USE OF 

2324
01:57:31,200 --> 01:57:31,840
DIVERSITY SUPPLEMENT FOR SMALL 

2325
01:57:31,840 --> 01:57:34,320
BUSINESS AWARDS.

2326
01:57:34,320 --> 01:57:35,760
EARLY ON WITH UNITE WITHIN THE 

2327
01:57:35,760 --> 01:57:38,120
FIRST MONTH WE WERE PUBLICLY 

2328
01:57:38,120 --> 01:57:40,280
UNVEILED, THERE WAS AN 

2329
01:57:40,280 --> 01:57:41,960
ANNOUNCEMENT OF SOMETHING CALLED

2330
01:57:41,960 --> 01:57:43,560
PEDP AS PART OF A FUNDING 

2331
01:57:43,560 --> 01:57:45,840
OPPORTUNITY ANNOUNCEMENT FROM 

2332
01:57:45,840 --> 01:57:48,000
THE NIH WIDE BRAIN INITIATIVE.

2333
01:57:48,000 --> 01:57:52,760
IT'S A FUNDING OPPORTUNITY 

2334
01:57:52,760 --> 01:57:53,280
ANNOUNCEMENT CALLING FOR 

2335
01:57:53,280 --> 01:57:56,760
CONSIDERATION OF PLANS TO 

2336
01:57:56,760 --> 01:57:58,640
ENHANCE DIVERSE PERSPECTIVES AS 

2337
01:57:58,640 --> 01:58:02,040
PART OF THE SCORING.

2338
01:58:02,040 --> 01:58:04,240
IT'S BROADLY DEFINED AND A 

2339
01:58:04,240 --> 01:58:07,320
KEEPING WITH NIH INTEREST IN 

2340
01:58:07,320 --> 01:58:07,760
DIVERSITY.

2341
01:58:07,760 --> 01:58:11,320
BY RACE, ETHNICITY, GENDER, 

2342
01:58:11,320 --> 01:58:19,520
DISABILITY STARTS  -- STATUS AND

2343
01:58:19,520 --> 01:58:25,840
THE GOAL IS TO HAVE THE LANGUAGE

2344
01:58:25,840 --> 01:58:35,720
PUT IN OTHER ANNOUNCEMENTS.

2345
01:58:35,720 --> 01:58:37,480
OTHER AREAS ARE PROMOTING 

2346
01:58:37,480 --> 01:58:39,640
INSTITUTIONAL CULTURE CHANGE IN 

2347
01:58:39,640 --> 01:58:42,720
SUPPORT OF INCLUSIVITY AND 

2348
01:58:42,720 --> 01:58:48,040
EQUITY ABOVE AND BEYOND THE 

2349
01:58:48,040 --> 01:58:52,480
FIRST INITIATIVE.

2350
01:58:52,480 --> 01:58:58,640
AND I ASK IF YOU AREN'T ALREADY 

2351
01:58:58,640 --> 01:59:01,840
A SUBSCRIBER TO MY BLOG KEEP AN 

2352
01:59:01,840 --> 01:59:02,520
EYE OUT.

2353
01:59:02,520 --> 01:59:03,880
WE MAY HAVE THINGS TO HELP 

2354
01:59:03,880 --> 01:59:04,440
SUPPORT THAT IN THE NEAR 

2355
01:59:04,440 --> 01:59:07,920
TEMPERATURE.

2356
01:59:07,920 --> 01:59:09,320
-- FUTURE.

2357
01:59:09,320 --> 01:59:11,480
THERE'S A LAUNCH TO CONDUCT 

2358
01:59:11,480 --> 01:59:13,040
OBJECTIVE CLIMATE ASSESSMENTS 

2359
01:59:13,040 --> 01:59:15,200
AND CRITICAL SELF-STUDIES AND 

2360
01:59:15,200 --> 01:59:15,840
DEVELOP ACTION PLANS BASED ON 

2361
01:59:15,840 --> 01:59:24,120
RESULTS.

2362
01:59:24,120 --> 01:59:27,120
FOR ADVANCEMENT IN EQUITY AND 

2363
01:59:27,120 --> 01:59:28,840
INCLUSION AND BUILD RESEARCH 

2364
01:59:28,840 --> 01:59:32,200
CAPACITY AT MINORITY SERVING 

2365
01:59:32,200 --> 01:59:32,520
INSTITUTIONS.

2366
01:59:32,520 --> 01:59:35,760
THIS WOULD INCLUDE BUILDING UPON

2367
01:59:35,760 --> 01:59:43,600
A MECHANISM CALLED S10 

2368
01:59:43,600 --> 01:59:50,960
INSTRUMENTATIONS.

2369
01:59:50,960 --> 01:59:55,240
INSTRUMENTATION GRANT AND THE 

2370
01:59:55,240 --> 02:00:00,640
DEVELOPMENT GRANTS PROGRAM.

2371
02:00:00,640 --> 02:00:01,640
SPAD IS PART OF THE BUILD 

2372
02:00:01,640 --> 02:00:03,240
INITIATIVE STARTED ALMOST A 

2373
02:00:03,240 --> 02:00:05,480
DECADE AGO NOW AND FOUND TO BE 

2374
02:00:05,480 --> 02:00:10,720
HELPFUL IN THE NETWORK OF 

2375
02:00:10,720 --> 02:00:14,360
INSTITUTIONS SUPPORT ED BY THAT 

2376
02:00:14,360 --> 02:00:16,120
INITIATIVE IN TERMS OF MAKING 

2377
02:00:16,120 --> 02:00:19,560
SURE THERE'S OFFICE OF RESEARCH 

2378
02:00:19,560 --> 02:00:21,640
ADMINISTRATION THAT CAN SUPPORT 

2379
02:00:21,640 --> 02:00:21,960
RESEARCHERS.

2380
02:00:21,960 --> 02:00:23,400
THE INTENT IS TO EXPAND WHAT HAS

2381
02:00:23,400 --> 02:00:28,600
BEEN DONE THERE.

2382
02:00:28,600 --> 02:00:30,040
PLANS FOR ENTREPRENEURIAL 

2383
02:00:30,040 --> 02:00:32,040
TRAINING AND POTENTIALLY HAVE A 

2384
02:00:32,040 --> 02:00:33,320
YEARLY MEETING BETWEEN NIH 

2385
02:00:33,320 --> 02:00:34,800
LEADERSHIP AND LEADERS OF 

2386
02:00:34,800 --> 02:00:38,040
MINORITY SERVING INSTITUTIONS.

2387
02:00:38,040 --> 02:00:40,000
THEN LOOKING INWARDLY, SOME 

2388
02:00:40,000 --> 02:00:44,080
PLANS TO IDENTIFY AND CHANGE NIH

2389
02:00:44,080 --> 02:00:47,480
PROCESSES AND POLICIES THAT 

2390
02:00:47,480 --> 02:00:48,640
CONTRIBUTE TO INEQUITIES IN 

2391
02:00:48,640 --> 02:00:50,640
FUNDING SUCH AS DEVELOPING AND 

2392
02:00:50,640 --> 02:00:52,640
LAUNCHING A TRAINING PROGRAM FOR

2393
02:00:52,640 --> 02:00:54,360
SCIENTIFIC REVIEW AND PROGRAM 

2394
02:00:54,360 --> 02:00:58,600
OFFICERS TO REDUCE IMPLICIT BIAS

2395
02:00:58,600 --> 02:01:00,680
AND INCREASE EQUITY AND 

2396
02:01:00,680 --> 02:01:03,240
INCLUSIVITY AND INTERACTIONS 

2397
02:01:03,240 --> 02:01:05,920
WITH INTRAMURAL COMMUNITY.

2398
02:01:05,920 --> 02:01:08,200
I'LL GIVE CSR CREDIT THEY'VE 

2399
02:01:08,200 --> 02:01:09,320
ALREADY DONE A WONDERFUL JOB 

2400
02:01:09,320 --> 02:01:12,920
TRAINING THEIR SROs AND 

2401
02:01:12,920 --> 02:01:16,280
REVIEWERS ABOUT IMPLICIT BIAS.

2402
02:01:16,280 --> 02:01:18,840
PLANS TO DEVELOP GUIDANCE TO 

2403
02:01:18,840 --> 02:01:21,080
HELP INSTITUTES AND CENTERS 

2404
02:01:21,080 --> 02:01:22,440
ENHANCE THE DIVERSITY OF THEIR 

2405
02:01:22,440 --> 02:01:24,840
PRINCIPLE INVESTIGATORS FUNDED 

2406
02:01:24,840 --> 02:01:26,920
IN THEIR RESEARCH PORTFOLIO.

2407
02:01:26,920 --> 02:01:30,200
PLANS TO IMPROVE REVIEW CRITERIA

2408
02:01:30,200 --> 02:01:30,920
DESCRIPTIONS TO DECREASE 

2409
02:01:30,920 --> 02:01:36,280
POSSIBLE SOURCES OF BIAS SUCH AS

2410
02:01:36,280 --> 02:01:38,840
INSTITUTION OR REPUTATIONAL 

2411
02:01:38,840 --> 02:01:39,560
BIAS.

2412
02:01:39,560 --> 02:01:41,160
AGAIN, SET UP A SCIENTIFIC 

2413
02:01:41,160 --> 02:01:43,160
REVIEW HAS BEEN IN THE VANGUARD 

2414
02:01:43,160 --> 02:01:45,160
IN TERMS OF EXPERIMENTING AND 

2415
02:01:45,160 --> 02:01:47,120
MEANS BY WHICH THAT CAN BE 

2416
02:01:47,120 --> 02:01:48,600
ACCOMPLISHED AND THE INTENT HERE

2417
02:01:48,600 --> 02:01:50,240
IS FOR THE UNITE INITIATIVE TO 

2418
02:01:50,240 --> 02:01:51,720
PARTNER WITH THEM AND HOPEFULLY 

2419
02:01:51,720 --> 02:01:54,360
ACCELERATE THAT PROCESS.

2420
02:01:54,360 --> 02:01:56,240
THEN FINALLY I'D LIKE TO TURN 

2421
02:01:56,240 --> 02:01:58,720
BACK TO THE RFI I'VE MENTIONED 

2422
02:01:58,720 --> 02:01:59,600
AT THE BEGINNING.

2423
02:01:59,600 --> 02:02:02,560
AS I SAID, WE HAD A REALLY 

2424
02:02:02,560 --> 02:02:05,360
ROBUST RESPONSE TO IT.

2425
02:02:05,360 --> 02:02:06,920
IT OPENED MARCH 1.

2426
02:02:06,920 --> 02:02:12,200
THE INTENT WAS TO HAVE IT CLOSE 

2427
02:02:12,200 --> 02:02:16,760
APRIL 10 AND THERE WAS SO MUCH 

2428
02:02:16,760 --> 02:02:17,760
INTEREST IN RESPONDING.

2429
02:02:17,760 --> 02:02:20,440
RESPONSE ALL ASPECTS OF THE 

2430
02:02:20,440 --> 02:02:21,280
BIOMEDICAL WORKFORCE AND 

2431
02:02:21,280 --> 02:02:22,960
POLICIES AND PARTNERSHIPS, 

2432
02:02:22,960 --> 02:02:23,760
RESEARCH AREAS AND OTHER IDEAS 

2433
02:02:23,760 --> 02:02:27,920
PEOPLE MIGHT HAVE.

2434
02:02:27,920 --> 02:02:31,040
WE ARE NOT DONE BUT AT A HIGH 

2435
02:02:31,040 --> 02:02:33,920
LEVEL OF THE 1100 RESPONSES 

2436
02:02:33,920 --> 02:02:42,280
ALMOST HALF WERE FROM ACADEMIA.

2437
02:02:42,280 --> 02:02:47,440
A LITTLE MORE THAN 10% FROM NIH 

2438
02:02:47,440 --> 02:02:50,120
AND THERE WERE POST-DOCS AND 

2439
02:02:50,120 --> 02:02:52,240
OTHERS AND THREE CROSS-CUTTING 

2440
02:02:52,240 --> 02:02:55,480
FINDINGS FROM THE TOP LEVEL 

2441
02:02:55,480 --> 02:02:58,240
ANALYSIS.

2442
02:02:58,240 --> 02:03:00,840
NUMBER 1, ACTION ARE MORE 

2443
02:03:00,840 --> 02:03:01,840
IMPORTANT THAN WORDS AND PEOPLE 

2444
02:03:01,840 --> 02:03:04,960
WERE NOT INTERESTED IN NIH DOING

2445
02:03:04,960 --> 02:03:05,800
POSTURING.

2446
02:03:05,800 --> 02:03:08,200
THIS IS MARCH THROUGH APRIL 

2447
02:03:08,200 --> 02:03:09,080
2021.

2448
02:03:09,080 --> 02:03:11,520
I HOPE PEOPLE SEE WE ARE ABOUT 

2449
02:03:11,520 --> 02:03:13,680
DOING THINGS.

2450
02:03:13,680 --> 02:03:15,640
SECOND WAS PEOPLE WERE LOOKING 

2451
02:03:15,640 --> 02:03:20,160
TO ENHANCE PROGRAMS AND 

2452
02:03:20,160 --> 02:03:21,000
ACTIVITIES.

2453
02:03:21,000 --> 02:03:23,160
I HOPE WE'LL ARE BEGINNING TO 

2454
02:03:23,160 --> 02:03:25,040
SEE WHAT WE ARE ABOUT AND 3, 

2455
02:03:25,040 --> 02:03:26,240
THERE'S NO EASY BUTTON.

2456
02:03:26,240 --> 02:03:30,080
AS A CO-LEAD OF THE INITIATIVE I

2457
02:03:30,080 --> 02:03:32,240
CAN'T AGREE MORE STRONGLY.

2458
02:03:32,240 --> 02:03:33,520
THERE'S NO ONE WAY OF GETTING 

2459
02:03:33,520 --> 02:03:39,000
ALL THE THINGS DONE THAT WED 

2460
02:03:39,000 --> 02:03:45,160
LIKE TO DO WE'RE TALKING ABOUT 

2461
02:03:45,160 --> 02:03:45,880
OVERALL PROCESS AND EVERY STEP 

2462
02:03:45,880 --> 02:03:47,560
TAKES YOU ALONG THE WAY.

2463
02:03:47,560 --> 02:03:52,720
THERE WERE A SMALL NUMBER OF 

2464
02:03:52,720 --> 02:03:55,640
RESPONDENTS WHO WE PERCEIVED NO 

2465
02:03:55,640 --> 02:03:57,680
PERCEPTION OF RACISM AND PEOPLE 

2466
02:03:57,680 --> 02:03:59,160
COULD INTERPRET THAT IN WHATEVER

2467
02:03:59,160 --> 02:03:59,760
FASHION THEY WOULD LIKE TO 

2468
02:03:59,760 --> 02:04:03,680
INTERPRET IT.

2469
02:04:03,680 --> 02:04:05,560
THE PLAN IS THERE'LL BE 

2470
02:04:05,560 --> 02:04:08,240
CONTINUED ANALYSIS AND SYNTHESIS

2471
02:04:08,240 --> 02:04:10,960
AND HOPEFULLY FULL REPORTS NOT 

2472
02:04:10,960 --> 02:04:13,800
TOO FAR INTO THE CALENDAR YEAR 

2473
02:04:13,800 --> 02:04:17,760
AND PLANS TO TRIANGULATE THE 

2474
02:04:17,760 --> 02:04:18,480
FINDINGS FROM THIS WITH 

2475
02:04:18,480 --> 02:04:22,200
LISTENING SESSIONS AND MAYBE YOU

2476
02:04:22,200 --> 02:04:24,120
HEARD OF THOSE HELD LATELY.

2477
02:04:24,120 --> 02:04:27,040
WE HOPE TO HAVE THIS AVAILABLE 

2478
02:04:27,040 --> 02:04:30,440
FOR EVERYONE TO LOOK AT IN THE 

2479
02:04:30,440 --> 02:04:32,280
NOT TOO DISTANT FUTURE AND 

2480
02:04:32,280 --> 02:04:33,680
APPRECIATE EVERYONE WHO HAS 

2481
02:04:33,680 --> 02:04:35,440
PROVIDED FEEDBACK AND HOPEFULLY 

2482
02:04:35,440 --> 02:04:38,240
AGAIN YOU HAVE BEGUN TO SEE THAT

2483
02:04:38,240 --> 02:04:39,360
WE'RE ADDRESSING A LOT OF THE 

2484
02:04:39,360 --> 02:04:40,600
THINGS THAT HAVE BEEN IDENTIFIED

2485
02:04:40,600 --> 02:04:44,640
AS CONCERNS.

2486
02:04:44,640 --> 02:04:52,240
I AM -- I HAVE NOT GIVEN YOU A 

2487
02:04:52,240 --> 02:04:54,560
FULL VIEW OF THE UNITE PROCESS.

2488
02:04:54,560 --> 02:04:59,160
PLEASE GO TO OUR WEBSITE.

2489
02:04:59,160 --> 02:05:03,360
YOU CAN GOOGLE NIH UNITE AND IT 

2490
02:05:03,360 --> 02:05:05,280
WILL TAKE YOU THERE OR USE THE 

2491
02:05:05,280 --> 02:05:06,560
URL TO GET TO THE MILESTONES AND

2492
02:05:06,560 --> 02:05:08,720
PERFECTING PAGE AND I WANT TO 

2493
02:05:08,720 --> 02:05:13,200
THANK THE 85 PLUS INDIVIDUALS 

2494
02:05:13,200 --> 02:05:16,640
WHO -- THERE'S ONLY TWO 

2495
02:05:16,640 --> 02:05:17,520
FULL-TIME PAID PEOPLE ON THE 

2496
02:05:17,520 --> 02:05:19,800
PROJECT AND THOSE WHO 

2497
02:05:19,800 --> 02:05:23,600
VOLUNTEERED THEIR TIME AND I'M 

2498
02:05:23,600 --> 02:05:31,560
HONORED TO CO-LEAD THIS WITH THE

2499
02:05:31,560 --> 02:05:32,720
PRINCIPLE DEPUTY DIRECTOR AND 

2500
02:05:32,720 --> 02:05:34,560
THE DIRECTOR OF MANAGEMENT AND I

2501
02:05:34,560 --> 02:05:37,240
REALLY SHOULD HAVE ENDED WITH MY

2502
02:05:37,240 --> 02:05:39,560
FAVORITE SLIDE WHICH IS GREAT 

2503
02:05:39,560 --> 02:05:41,240
MINDS THINK DIFFERENTLY BUT I'D 

2504
02:05:41,240 --> 02:05:42,040
BE HAPPY TO ANSWER QUESTIONS AT 

2505
02:05:42,040 --> 02:05:44,480
THIS POINT.

2506
02:05:44,480 --> 02:05:46,880
>> THANKS SO MUCH, MARIE.

2507
02:05:46,880 --> 02:05:47,640
THAT WAS INFORMATIVE AND 

2508
02:05:47,640 --> 02:05:50,640
INSPIRATIONAL.

2509
02:05:50,640 --> 02:05:51,040
ARE THERE QUESTIONS?

2510
02:05:51,040 --> 02:05:58,200
DISCUSSION?

2511
02:05:58,200 --> 02:06:03,320
HOW ARE THESE ISSUSUES PLAYING
OUT

2512
02:06:03,320 --> 02:06:03,920
IN YOUR INSTITUTION.

2513
02:06:03,920 --> 02:06:05,840
A GREAT OPPORTUNITY TO DISCUSS.

2514
02:06:05,840 --> 02:06:06,160
VICKY.

2515
02:06:06,160 --> 02:06:10,160
>> I WANTED TO CONGRATULATION 

2516
02:06:10,160 --> 02:06:14,120
DR. BERNARD AS SOMEONE WHOSE 

2517
02:06:14,120 --> 02:06:17,440
BEEN WORKING ON THESE ISSUES 

2518
02:06:17,440 --> 02:06:20,360
WITHIN OUR PROFESSIONS IN 

2519
02:06:20,360 --> 02:06:23,640
LANGUAGE AND THIS IS SEE CHANGE 

2520
02:06:23,640 --> 02:06:23,840
WORK.

2521
02:06:23,840 --> 02:06:25,360
YOU'VE DONE A GREAT DEAL IN A 

2522
02:06:25,360 --> 02:06:26,760
SHORT PERIOD OF TIME.

2523
02:06:26,760 --> 02:06:29,040
CONGRATULATIONS ON THE SURGE.

2524
02:06:29,040 --> 02:06:34,880
I WAS REALLY GLAD TO SEE THAT 

2525
02:06:34,880 --> 02:06:36,560
THERE ARE PLANS FOR LOOKING 

2526
02:06:36,560 --> 02:06:38,320
STRUCTURALL

2527
02:06:38,320 --> 02:06:38,640
STRUCTURALLY.

2528
02:06:38,640 --> 02:06:41,000
LOOKING AT THE POLICIES AND 

2529
02:06:41,000 --> 02:06:44,680
PROCEDURES AND EXPECTATIONS OF 

2530
02:06:44,680 --> 02:06:46,800
REVIEWERS SO THAT ONCE WE BRING 

2531
02:06:46,800 --> 02:06:49,480
ALL THIS GREAT DIVERSITY IN, 

2532
02:06:49,480 --> 02:06:53,040
THEY CAN STILL GET FUNDED AND 

2533
02:06:53,040 --> 02:06:56,440
THEY'RE WILLING TO REMAIN A PART

2534
02:06:56,440 --> 02:06:59,520
OF THE SYSTEMS THAT NIH HAS.

2535
02:06:59,520 --> 02:07:06,440
THE QUESTION I HAVE IS RELATIVE 

2536
02:07:06,440 --> 02:07:09,440
TO -- THEY WERE CALLED REAPS, I 

2537
02:07:09,440 --> 02:07:11,560
THINK, BUT THEY WERE EQUITY 

2538
02:07:11,560 --> 02:07:12,040
PLANS.

2539
02:07:12,040 --> 02:07:15,680
I'M WONDERING WHAT GUIDANCE YOUR

2540
02:07:15,680 --> 02:07:17,400
PROVIDING INDIVIDUALS AS THEY'RE

2541
02:07:17,400 --> 02:07:18,240
DEVELOPING THOSE PLANS.

2542
02:07:18,240 --> 02:07:19,840
>> THANK YOU FOR THE QUESTION.

2543
02:07:19,840 --> 02:07:25,080
>> YES, WE CALL THEM RACIAL AND 

2544
02:07:25,080 --> 02:07:28,040
ETHNIC EQUITY PLANS OR REEP.

2545
02:07:28,040 --> 02:07:31,040
THERE'S BEEN A SMALL CADRE OF 

2546
02:07:31,040 --> 02:07:32,800
SUBJECT MATTER EXPERTS HERE AT 

2547
02:07:32,800 --> 02:07:34,440
NIH WHO KNOW ABOUT BEHAVIORAL 

2548
02:07:34,440 --> 02:07:35,320
AND SOCIAL RESEARCH AND KNOW 

2549
02:07:35,320 --> 02:07:37,600
ABOUT INSTITUTIONAL CULTURE 

2550
02:07:37,600 --> 02:07:41,240
CHANGE AS WELL AS AN OUTSIDE 

2551
02:07:41,240 --> 02:07:43,560
CONSULTANT WHOSE WORKED WITH US 

2552
02:07:43,560 --> 02:07:47,800
DR. JAY BRUCE STEWART DURING THE

2553
02:07:47,800 --> 02:07:50,680
OBAMA WAS RESPONSE I AM FOR A 

2554
02:07:50,680 --> 02:07:51,960
GOVERNMENT WIDE EQUITY AND 

2555
02:07:51,960 --> 02:07:53,880
INCLUSION EXECUTIVE ORDER AND 

2556
02:07:53,880 --> 02:07:55,320
WORKED WITH PERSONAL MANAGEMENT.

2557
02:07:55,320 --> 02:07:57,040
THIS CADRE OF FOLKS HAVE WORKED 

2558
02:07:57,040 --> 02:07:58,240
HARD BETWEEN THE BEGINNING OF 

2559
02:07:58,240 --> 02:08:00,480
ALL THIS AND BEGINNING OF 

2560
02:08:00,480 --> 02:08:01,960
NOVEMBER TO DEVELOP GUIDANCE TO 

2561
02:08:01,960 --> 02:08:04,760
HELP ALL THE INSTITUTES AND 

2562
02:08:04,760 --> 02:08:07,320
CENTERS TO THINK THROUGH HOW 

2563
02:08:07,320 --> 02:08:08,760
THEY SHOULD DO THIS.

2564
02:08:08,760 --> 02:08:13,280
IT'S A 24-PAGE DOCUMENT WITH THE

2565
02:08:13,280 --> 02:08:16,440
THEORY BEHIND IT EXAMPLES OF HOW

2566
02:08:16,440 --> 02:08:18,000
YOU MIGHT GO ABOUT IT AND 

2567
02:08:18,000 --> 02:08:22,560
TEMPLATES TO USE AND NOW SINCE 

2568
02:08:22,560 --> 02:08:25,680
NOVEMBER 4 THROUGH OCTOBER 1 

2569
02:08:25,680 --> 02:08:26,560
THEY'RE AVAILABLE FOR 

2570
02:08:26,560 --> 02:08:30,800
CONSULTATION TO HELP IN MOVING 

2571
02:08:30,800 --> 02:08:35,040
THIS FORWARD.

2572
02:08:35,040 --> 02:08:36,840
THERE HAVE BEEN NIH CONSULTATION

2573
02:08:36,840 --> 02:08:38,560
AND CONTACTS WILL BEGIN 

2574
02:08:38,560 --> 02:08:42,040
CONVENING ON A REGULAR BASIS SO 

2575
02:08:42,040 --> 02:08:43,720
PEOPLE COMPARE AND CONTRAST 

2576
02:08:43,720 --> 02:08:45,240
CHALLENGES THEY'RE FACING.

2577
02:08:45,240 --> 02:08:49,400
WE'RE DOING OUR BEST TO PROVIDE 

2578
02:08:49,400 --> 02:08:51,000
A LOT OF SUPPORT BUT IT WILL 

2579
02:08:51,000 --> 02:08:53,480
ULTIMATELY COME DOWN IT EACH 

2580
02:08:53,480 --> 02:08:54,240
INSTITUTE AND CENTER BECAUSE 

2581
02:08:54,240 --> 02:09:00,120
EACH HAS ITS OWN UNIQUE CULTURE 

2582
02:09:00,120 --> 02:09:01,920
AN NEEDS.

2583
02:09:01,920 --> 02:09:03,840
IT WILL BE INTERESTING TO SEE 

2584
02:09:03,840 --> 02:09:04,640
WHAT WE HAVE COME APRIL 1.

2585
02:09:04,640 --> 02:09:18,160
>> THANK YOU.

2586
02:09:18,160 --> 02:09:20,040
>> OTHER COMMENTS OR QUESTIONS.

2587
02:09:20,040 --> 02:09:22,440
>> I'D WLIK TO ASK A QUESTION, 

2588
02:09:22,440 --> 02:09:23,560
IF I MAY.

2589
02:09:23,560 --> 02:09:28,920
YOU TALKED A LOT ABOUT COHORTS 

2590
02:09:28,920 --> 02:09:32,520
AND I THINK THAT'S SOMETHING WE 

2591
02:09:32,520 --> 02:09:33,640
THOUGHT ABOUT AND YOU WENT 

2592
02:09:33,640 --> 02:09:37,040
THROUGH IT QUICKLY SO SORRY IF I

2593
02:09:37,040 --> 02:09:39,760
MISSED IT CAN YOU TALK ABOUT THE

2594
02:09:39,760 --> 02:09:41,160
CONSOLATION OF COHORTS BY CAREER

2595
02:09:41,160 --> 02:09:43,440
STAGE AND IT SEEMS LIKE A 

2596
02:09:43,440 --> 02:09:44,600
CONSTRUCT WE'RE THINKING ABOUT 

2597
02:09:44,600 --> 02:09:45,720
AT OUR UNIVERSITY.

2598
02:09:45,720 --> 02:09:51,000
TO TALK ABOUT THAT MORE WOULD BE

2599
02:09:51,000 --> 02:09:51,240
WONDERFUL.

2600
02:09:51,240 --> 02:09:55,080
>> I WAS HERE TO TALK ABOUT NIH 

2601
02:09:55,080 --> 02:09:56,560
UNITE AND DIDN'T TAKE AN 

2602
02:09:56,560 --> 02:09:58,840
ADVANTAGE ABOUT WHAT MY OFFICE 

2603
02:09:58,840 --> 02:10:00,640
OF THE OFFICE OF SCIENTIFIC 

2604
02:10:00,640 --> 02:10:02,040
WORKFORCE DIVERSITY IS DOING AND

2605
02:10:02,040 --> 02:10:06,320
I DON'T KNOW I'LL BE ABLE TO 

2606
02:10:06,320 --> 02:10:08,320
PICK IT UP QUICKLY BUT WILL SEND

2607
02:10:08,320 --> 02:10:09,760
IT FOR DISSEMINATION WE'RE 

2608
02:10:09,760 --> 02:10:16,680
HAVING A WORKSHOP FEBRUARY 23 

2609
02:10:16,680 --> 02:10:18,440
AND 24 FOR THE IMPLEMENTATION 

2610
02:10:18,440 --> 02:10:24,040
FOR COHORTS BECAUSE IT CAN BE 

2611
02:10:24,040 --> 02:10:25,360
EFFECTIVE THROUGHOUT THE PATHWAY

2612
02:10:25,360 --> 02:10:26,240
OF BECOMING A SCIENTIST AND 

2613
02:10:26,240 --> 02:10:32,040
PROGRAM FOR COHORTS AT THE 

2614
02:10:32,040 --> 02:10:33,320
POST-DOC LEVEL AND EARLY CAREER 

2615
02:10:33,320 --> 02:10:34,720
LEVEL PARTICULARLY SOMETHING 

2616
02:10:34,720 --> 02:10:39,920
CALLED THE MOSAIC AWARD 

2617
02:10:39,920 --> 02:10:45,000
SPONSORED BY THE INSTITUTE OF 

2618
02:10:45,000 --> 02:10:49,000
SCIENCES AND THE KEY -- ONE OF 

2619
02:10:49,000 --> 02:10:52,480
THE KEY COMPONENTS OF THAT IS 

2620
02:10:52,480 --> 02:10:53,520
ALLOWING THOSE PEOPLE TO GET 

2621
02:10:53,520 --> 02:10:56,040
TOGETHER AND BE SUPPORTIVE OF 

2622
02:10:56,040 --> 02:10:58,120
EACH OTHER, MAKING SURE THEY'RE 

2623
02:10:58,120 --> 02:10:59,680
GETTING EXTRA SUPPORT AND 

2624
02:10:59,680 --> 02:11:01,240
MENTORING FROM PEOPLE WHO ARE 

2625
02:11:01,240 --> 02:11:03,360
EXCELLENT MENTORS.

2626
02:11:03,360 --> 02:11:06,240
AND BEING SENSITIVE TO WHAT THE 

2627
02:11:06,240 --> 02:11:08,240
ENVIRONMENT TRULY IS WHERE THEY 

2628
02:11:08,240 --> 02:11:10,920
ARE AND WHAT SORTS OF CHANGES 

2629
02:11:10,920 --> 02:11:12,600
MAY NEED TO BE MADE, ADJUSTMENTS

2630
02:11:12,600 --> 02:11:14,000
MAY NEED TO BE MADE TO THE 

2631
02:11:14,000 --> 02:11:14,280
ENVIRONMENT.

2632
02:11:14,280 --> 02:11:19,400
WHEN I WAS TALKING ABOUT THE 

2633
02:11:19,400 --> 02:11:23,560
THINGS COMING FORWARD IN THE 

2634
02:11:23,560 --> 02:11:25,600
NEXT MANY MONTHS LOOKING AT 

2635
02:11:25,600 --> 02:11:27,360
ENVIRONMENT AND AWARDS FOR 

2636
02:11:27,360 --> 02:11:28,680
MENTORING, THOSE ARE ALL 

2637
02:11:28,680 --> 02:11:32,360
COMPONENTS OF IT AND IT'S ALL 

2638
02:11:32,360 --> 02:11:35,200
PUT TOGETHER IN AN INITIATIVE 

2639
02:11:35,200 --> 02:11:36,880
AND IN THE NATIONAL INSTITUTE OF

2640
02:11:36,880 --> 02:11:40,560
GENERAL MEDICAL SCIENCES AND THE

2641
02:11:40,560 --> 02:11:46,600
MOSAIC K99R00 IN THE RECRUITMENT

2642
02:11:46,600 --> 02:11:48,120
OF ADVANCEMENT OF CAREER -- I'M 

2643
02:11:48,120 --> 02:11:50,520
NOT GOING TO BE ABLE TO GIVE YOU

2644
02:11:50,520 --> 02:11:56,920
THE FULL BUT IRACDA IS ANOTHER 

2645
02:11:56,920 --> 02:11:57,160
EXAMPLE.

2646
02:11:57,160 --> 02:12:02,480
THERE'S A LOT OUT THERE.

2647
02:12:02,480 --> 02:12:07,920
THERE'S THE ASSOCIATIONS OF THE 

2648
02:12:07,920 --> 02:12:10,880
AMERICANS C CHANGE INITIATIVE.

2649
02:12:10,880 --> 02:12:14,640
WE'LL TALK ABOUT THAT FEBRUARY 

2650
02:12:14,640 --> 02:12:15,720
23 THROUGH 24.

2651
02:12:15,720 --> 02:12:17,200
>> THANK YOU AND THANKS FOR A 

2652
02:12:17,200 --> 02:12:17,720
GREAT TALK.

2653
02:12:17,720 --> 02:12:18,600
I REALLY ENJOYED IT.

2654
02:12:18,600 --> 02:12:25,840
>> THANK YOU.

2655
02:12:25,840 --> 02:12:28,520
>> I ENJOYED YOUR TALK.

2656
02:12:28,520 --> 02:12:30,240
I ASSUMED A NEW ROLE AS 

2657
02:12:30,240 --> 02:12:32,080
ASSOCIATE DEAN FOR STUDENT 

2658
02:12:32,080 --> 02:12:34,520
RESEARCH AND INCLUSIVELY I WANT 

2659
02:12:34,520 --> 02:12:36,640
MY INSTITUTION TO THINK ABOUT 

2660
02:12:36,640 --> 02:12:42,240
THE YEAR THAT STUDENTS TAKE OFF 

2661
02:12:42,240 --> 02:12:48,120
TO DO RESEARCH.

2662
02:12:48,120 --> 02:12:51,280
I WANT THEM TO THINK BIT IN THE 

2663
02:12:51,280 --> 02:12:53,280
SAME CONTEXT AS FINANCIAL AID 

2664
02:12:53,280 --> 02:12:54,840
BECAUSE THERE'S UNEQUAL ACCESS 

2665
02:12:54,840 --> 02:12:56,640
IN TAKING THE EXTRA YEAR OFF AND

2666
02:12:56,640 --> 02:12:58,200
IN THE CONTEXT OF RESEARCH BUT 

2667
02:12:58,200 --> 02:13:00,440
NO I THINK WHAT WE NEED TO DO IS

2668
02:13:00,440 --> 02:13:05,400
TO THINK OF IT IN CONTEXT OF 

2669
02:13:05,400 --> 02:13:06,680
BEING LEVELLING THE PLAYING 

2670
02:13:06,680 --> 02:13:07,760
FIELD SO EVERYONE HAS THE 

2671
02:13:07,760 --> 02:13:09,240
OPPORTUNITY TO TAKE THE YEAR OFF

2672
02:13:09,240 --> 02:13:11,400
AND THERE'S NOT A FINANCIAL 

2673
02:13:11,400 --> 02:13:13,640
IMPEDIMENT TO DOING SO.

2674
02:13:13,640 --> 02:13:15,800
I'M NOT SURE HOW THE NIH CAN 

2675
02:13:15,800 --> 02:13:18,440
PLAY A ROLE BUT WOULD BE 

2676
02:13:18,440 --> 02:13:20,080
FANTASTIC IF THERE WAS NON-NIH 

2677
02:13:20,080 --> 02:13:22,160
PROGRAM SUPPORT FOR PROGRAMS OUT

2678
02:13:22,160 --> 02:13:23,240
THERE BECAUSE THERE ISN'T ALWAYS

2679
02:13:23,240 --> 02:13:25,960
THE WEALTH AT MANY INSTITUTIONS 

2680
02:13:25,960 --> 02:13:31,400
TO SUPPORT THE FIRST ACADEMIC 

2681
02:13:31,400 --> 02:13:35,840
EXPERIENCE WITH A MENTOR WHO MAY

2682
02:13:35,840 --> 02:13:38,040
NOT BE FUND ORDER HAVE THAT 

2683
02:13:38,040 --> 02:13:38,640
RESOURCE.

2684
02:13:38,640 --> 02:13:40,640
YOUR THOUGHTS ABOUT THAT.

2685
02:13:40,640 --> 02:13:42,480
>> THAT'S A GOOD QUESTION AND 

2686
02:13:42,480 --> 02:13:46,600
SOMETHING WE'RE STRUGGLING WITH.

2687
02:13:46,600 --> 02:13:48,440
FOR INSTANCE, YOU CAN OFTEN 

2688
02:13:48,440 --> 02:13:50,280
THINK ABOUT MAYBE WHAT YOU CAN 

2689
02:13:50,280 --> 02:13:51,440
DO IS PROVIDE SUPPORT FOR 

2690
02:13:51,440 --> 02:13:53,040
MENTORS AND THOSE MENTORS CAN 

2691
02:13:53,040 --> 02:13:54,720
SUPPORT THOSE STUDENTS WHO COME 

2692
02:13:54,720 --> 02:13:56,400
FROM UNDER REPRESENTED 

2693
02:13:56,400 --> 02:13:57,840
BACKGROUNDS BUT IF THOSE MENTORS

2694
02:13:57,840 --> 02:13:59,640
DON'T HAVE NIH FUNDING WE'RE 

2695
02:13:59,640 --> 02:14:03,560
KIND OF HARD PRESSED TO BUY THE 

2696
02:14:03,560 --> 02:14:03,840
FUNDING.

2697
02:14:03,840 --> 02:14:05,440
BUT WHILE HAVE TO THINK ABOUT 

2698
02:14:05,440 --> 02:14:06,840
ARE THERE CREATIVE WAYS MUCH 

2699
02:14:06,840 --> 02:14:08,400
GETTING THERE.

2700
02:14:08,400 --> 02:14:12,520
I WOULD CERTAINLY SAY THAT THE 

2701
02:14:12,520 --> 02:14:13,120
DIVERSITY SUPPLEMENT PROGRAM 

2702
02:14:13,120 --> 02:14:15,480
THAT NIH HAS IS A GREAT MEANS OF

2703
02:14:15,480 --> 02:14:20,640
HELPING PEOPLE EARLY IN THEIR 

2704
02:14:20,640 --> 02:14:28,560
CAREERS TO ADVANCE, AGAIN, IT 

2705
02:14:28,560 --> 02:14:31,600
HAS TO BE A SUPPLEMENT TO 

2706
02:14:31,600 --> 02:14:34,680
SOMEONE NIH FUNDED THOUGH THE 

2707
02:14:34,680 --> 02:14:39,840
NUMBER HAVE GONE UP ONLY 4.3% 

2708
02:14:39,840 --> 02:14:43,640
HAVE DIVERSITY SUPPLEMENTS 

2709
02:14:43,640 --> 02:14:44,240
SORNTED SO THERE'S OPPORTUNITY 

2710
02:14:44,240 --> 02:14:45,360
THERE.

2711
02:14:45,360 --> 02:14:48,640
WITH NEED TO CONTINUE TO FIGURE 

2712
02:14:48,640 --> 02:14:52,040
OUT WAYS OF RECOGNIZING THE GAP 

2713
02:14:52,040 --> 02:14:53,840
AND IT'S SOMETHING THAT PEOPLE 

2714
02:14:53,840 --> 02:14:55,560
ARE THINKING ABOUT.

2715
02:14:55,560 --> 02:14:58,760
>> THANK YOU.

2716
02:14:58,760 --> 02:15:01,400
>> WE HAVE A ROBUST DIVERSITY 

2717
02:15:01,400 --> 02:15:02,880
SUPPLEMENT PROGRAM AT NIDCD AND 

2718
02:15:02,880 --> 02:15:03,680
WE'LL BE GIVING MORE INFORMATION

2719
02:15:03,680 --> 02:15:12,080
ABOUT THAT TOMORROW.

2720
02:15:12,080 --> 02:15:16,400
>> THANK YOU FOR YOUR LOVELY 

2721
02:15:16,400 --> 02:15:17,240
PRESENTATION AND FOR ALL THE 

2722
02:15:17,240 --> 02:15:18,800
GREAT WORK YOU AND YOUR TEAM 

2723
02:15:18,800 --> 02:15:19,240
HAVE BEEN DOING.

2724
02:15:19,240 --> 02:15:22,920
I WANTED TO MENTION THAT AT A 

2725
02:15:22,920 --> 02:15:29,440
LOCAL LEVEL WE SEE THE INFLUENCE

2726
02:15:29,440 --> 02:15:32,000
OF FOR EXAMPLE THE COHORT AWARD.

2727
02:15:32,000 --> 02:15:35,680
I'M AT AN INSTITUTION THAT TAKES

2728
02:15:35,680 --> 02:15:37,160
A LOT OF PRIDE IN ITS 

2729
02:15:37,160 --> 02:15:38,280
ESTABLISHED TRADITIONS.

2730
02:15:38,280 --> 02:15:40,840
IT WAS FUN TO SEE HOW NIH 

2731
02:15:40,840 --> 02:15:46,760
BRINGING OUT THAT COHORT WARD 

2732
02:15:46,760 --> 02:15:47,880
CAUSED A REAL CHANGE IN ATTITUDE

2733
02:15:47,880 --> 02:15:50,440
TOWARDS THE IDEA OF BRING INNING

2734
02:15:50,440 --> 02:15:52,040
GROUPS OF FACULTY RATHER THAN 

2735
02:15:52,040 --> 02:15:55,600
HAVING THAT REAL FOCUS ON THE 

2736
02:15:55,600 --> 02:15:56,440
INDIVIDUAL.

2737
02:15:56,440 --> 02:15:58,640
MAYBE YOU KNOW WHAT I'M TALKING 

2738
02:15:58,640 --> 02:15:58,840
ABOUT.

2739
02:15:58,840 --> 02:16:02,920
GOING FURTHER THAN THAT, NIH 

2740
02:16:02,920 --> 02:16:04,080
OBVIOUSLY HAS A LOT OF INFLUENCE

2741
02:16:04,080 --> 02:16:05,040
ON BIOMEDICAL PARTS OF 

2742
02:16:05,040 --> 02:16:06,760
UNIVERSITIES BUT WE CAN STILL 

2743
02:16:06,760 --> 02:16:10,440
RUN UP AGAINST RESISTANCE IN THE

2744
02:16:10,440 --> 02:16:11,600
NON-BIOMEDICAL PARTS OF THE 

2745
02:16:11,600 --> 02:16:14,160
UNIVERSITIES WHICH CAN BE VERY 

2746
02:16:14,160 --> 02:16:15,600
IMPORTANT IN SORT OF HIRING AND 

2747
02:16:15,600 --> 02:16:19,640
RECRUITMENT.

2748
02:16:19,640 --> 02:16:22,360
SO AT THE PROVOST OFFICE, FOR 

2749
02:16:22,360 --> 02:16:22,640
EXAMPLE.

2750
02:16:22,640 --> 02:16:25,240
IS NIH TEAMING UP -- YOU 

2751
02:16:25,240 --> 02:16:28,400
MENTIONMENTION

2752
02:16:28,400 --> 02:16:36,400
ED AAAS, ARE THEY TEAMING UP TO 

2753
02:16:36,400 --> 02:16:37,720
EXPAND THE INFLUENCE IN THE 

2754
02:16:37,720 --> 02:16:38,160
BIOMEDICAL SPHERE?

2755
02:16:38,160 --> 02:16:39,720
>> THAT'S ANOTHER -- WE ARE 

2756
02:16:39,720 --> 02:16:40,840
APPROACHING IT FROM THE 

2757
02:16:40,840 --> 02:16:43,960
STANDPOINT OF WANTING TO TO TALK

2758
02:16:43,960 --> 02:16:47,480
WITH ACADEMIC LEADERS ABOUT FOR 

2759
02:16:47,480 --> 02:16:49,920
INSTANCE, WHAT ARE THIS CRITERIA

2760
02:16:49,920 --> 02:16:52,480
USED FOR ADVANCEMENT?

2761
02:16:52,480 --> 02:16:54,800
THE PEOPLE WHO MAY BE INVOLVED 

2762
02:16:54,800 --> 02:16:56,320
WITH HEALTH DISPARITIES 

2763
02:16:56,320 --> 02:16:58,640
RESEARCH, WITH LOTS OF MENTORING

2764
02:16:58,640 --> 02:17:00,520
OF UNDER REPRESENTED GROUP 

2765
02:17:00,520 --> 02:17:04,480
SCIENTISTS MAY NOT HAVE ALL THE 

2766
02:17:04,480 --> 02:17:06,600
PUBLICATIONS AND CELL AND NEURON

2767
02:17:06,600 --> 02:17:09,440
NECESSARY OFTEN TIMES FOR 

2768
02:17:09,440 --> 02:17:10,600
PROMOTION.

2769
02:17:10,600 --> 02:17:11,200
CAN'T THOSE OTHER IMPORTANT 

2770
02:17:11,200 --> 02:17:12,360
THINGS BE CONSIDERED.

2771
02:17:12,360 --> 02:17:13,760
WE'RE INTERESTED IN HAVING 

2772
02:17:13,760 --> 02:17:15,600
CONVERSATIONS ABOUT THAT AND AS 

2773
02:17:15,600 --> 02:17:18,040
THEY GET LAUNCHED, THEY WON'T 

2774
02:17:18,040 --> 02:17:18,840
NECESSARILY JUST BE IN THE 

2775
02:17:18,840 --> 02:17:20,680
SCHOOL OF MEDICINE.

2776
02:17:20,680 --> 02:17:23,080
IT WILL BE AT A BROADER LEVEL, 

2777
02:17:23,080 --> 02:17:23,400
ABSOLUTELY.

2778
02:17:23,400 --> 02:17:25,640
SO WE'RE JUST GETTING STARTED.

2779
02:17:25,640 --> 02:17:27,600
WE'RE THINKING ABOUT IT.

2780
02:17:27,600 --> 02:17:28,960
DR. TUCCI WILL HELP US QUITE A 

2781
02:17:28,960 --> 02:17:32,640
BIT WITH THAT.

2782
02:17:32,640 --> 02:17:35,280
YES, THERE'S A LOT OF TO BE 

2783
02:17:35,280 --> 02:17:35,480
DONE.

2784
02:17:35,480 --> 02:17:38,640
WHEN WE ANNOUNCED WE WANTED TO 

2785
02:17:38,640 --> 02:17:40,720
END STRUCTURAL RACISM, I 

2786
02:17:40,720 --> 02:17:43,440
PERSONAL THOUGHT, WOW, WE'RE 

2787
02:17:43,440 --> 02:17:45,960
BITING OFF QUITE A BIT THERE.

2788
02:17:45,960 --> 02:17:47,640
WE DON'T HAVE CONTROL OF ALL THE

2789
02:17:47,640 --> 02:17:49,640
THINGS THAT CONTRIBUTE TO IT BUT

2790
02:17:49,640 --> 02:17:53,920
WE ARE BRANCHING OUT AND DOING 

2791
02:17:53,920 --> 02:17:54,960
MORE AND INTERESTED HOW OUR 

2792
02:17:54,960 --> 02:17:55,640
CONVERSATIONS GO.

2793
02:17:55,640 --> 02:17:58,400
DR. TUCCI, DO YOU WANT TO 

2794
02:17:58,400 --> 02:17:59,520
ELABORATE AT ALL?

2795
02:17:59,520 --> 02:18:02,000
>> I THINK ONE OF THE THINGS WE 

2796
02:18:02,000 --> 02:18:05,120
STRUGGLE WITH IS THERE'S ONLY SO

2797
02:18:05,120 --> 02:18:07,640
MUCH THAT'S IN THE NIH PURVIEW 

2798
02:18:07,640 --> 02:18:09,360
AND A LOT IS IN THE PURVIEW OF 

2799
02:18:09,360 --> 02:18:11,280
THE ACADEMIC INSTITUTIONS.

2800
02:18:11,280 --> 02:18:15,640
TRYING TO FIGURE OUT HOW WE CAN 

2801
02:18:15,640 --> 02:18:18,160
PARTNER, HOW WE CAN PARTNER AND 

2802
02:18:18,160 --> 02:18:19,320
INFLUENCE IS SOMETHING I THINK 

2803
02:18:19,320 --> 02:18:21,120
ABOUT A LOT.

2804
02:18:21,120 --> 02:18:23,000
HOW DO YOU REWARD FACULTY FOR 

2805
02:18:23,000 --> 02:18:26,120
ENGAGING IN EFFORTS THAT PROMOTE

2806
02:18:26,120 --> 02:18:28,960
DIVERSITY AND INCLUSION WHEN WE 

2807
02:18:28,960 --> 02:18:31,360
HAVE A TENURE SYSTEM?

2808
02:18:31,360 --> 02:18:34,200
HOW DO YOU INFLUENCE SALARIES OF

2809
02:18:34,200 --> 02:18:36,880
UNDER REPRESENTED MINORITIES AND

2810
02:18:36,880 --> 02:18:40,000
WOMEN WHO ARE OFTEN HAVING LOWER

2811
02:18:40,000 --> 02:18:42,160
SALARIES THAN WHITE MALES?

2812
02:18:42,160 --> 02:18:46,280
HOW CAN WE USE THE BULLY PULPIT 

2813
02:18:46,280 --> 02:18:48,400
AND PARTNER AND COLLABORATE WITH

2814
02:18:48,400 --> 02:18:51,680
OTHER INSTITUTIONS AND AGENCIES 

2815
02:18:51,680 --> 02:19:05,960
TO DRIVE AND SEE CHANGE.

2816
02:19:05,960 --> 02:19:09,040
>> I HOPE YOU'LL BE ABLE TO HOOK

2817
02:19:09,040 --> 02:19:11,320
PEOPLE RESISTANT TO CHANGE 

2818
02:19:11,320 --> 02:19:12,320
RATHER THE PEOPLE ON BOARD OF 

2819
02:19:12,320 --> 02:19:13,800
COURSE YOU USE THE PEOPLE ON 

2820
02:19:13,800 --> 02:19:15,880
BOARD TO BRING IN THE OTHERS.

2821
02:19:15,880 --> 02:19:18,120
I GUESS I DO THINK NIH HAS A LOT

2822
02:19:18,120 --> 02:19:21,600
OF LEVERAGE AND CAN REACH THE 

2823
02:19:21,600 --> 02:19:28,440
MORE RESASSISTANT FOLKS OR 

2824
02:19:28,440 --> 02:19:28,800
INSTITUTIONS.

2825
02:19:28,800 --> 02:19:33,400
>> I HAVE A DISRUPTOR ROW 

2826
02:19:33,400 --> 02:19:33,960
PROPOSAL FOR ADDRESSING THE 

2827
02:19:33,960 --> 02:19:37,440
QUESTION RAISED.

2828
02:19:37,440 --> 02:19:43,480
MARIE,  IT'S A GREAT TALK AND 

2829
02:19:43,480 --> 02:19:44,880
YOU MENTION SOME MAY NOT HAVE 

2830
02:19:44,880 --> 02:19:46,200
ACCESS TO JOBS.

2831
02:19:46,200 --> 02:19:48,280
IT'S IMPORTANT TO RECOGNIZE 

2832
02:19:48,280 --> 02:19:50,840
NATURE PRESS, CELL PRESS, THESE 

2833
02:19:50,840 --> 02:19:51,200
ARE BUSINESSES.

2834
02:19:51,200 --> 02:19:54,800
THEY'RE NOT ACADEMIC.

2835
02:19:54,800 --> 02:19:58,680
THE RISE OF BIBLIOMETRICS HAS 

2836
02:19:58,680 --> 02:20:01,360
CAPTIVATED SCHOOLS AND USE THIS 

2837
02:20:01,360 --> 02:20:03,920
AS A METRIC FOR IMPORTANCE AND 

2838
02:20:03,920 --> 02:20:05,760
USE IT FOR HIRING TENURE AND ALL

2839
02:20:05,760 --> 02:20:07,320
KINDS OF DECISIONS.

2840
02:20:07,320 --> 02:20:13,280
THE BULLY PULPIT I ALWAYS 

2841
02:20:13,280 --> 02:20:15,440
THOUGHT SOCIETIES AND NIH CAN 

2842
02:20:15,440 --> 02:20:22,560
USE IS TO DEE DEINCENTIVIZE THE 

2843
02:20:22,560 --> 02:20:25,240
USE OF BIBLIOMETRICS AND NO 

2844
02:20:25,240 --> 02:20:26,680
REASON THEY SHOULD HAVE POWER 

2845
02:20:26,680 --> 02:20:29,240
OUR INSTITUTIONS AND I SUSPECT 

2846
02:20:29,240 --> 02:20:32,200
THE METRICS WORKED AGAINST 

2847
02:20:32,200 --> 02:20:34,920
D.E.I., THAT IS THEY ARE PROXIES

2848
02:20:34,920 --> 02:20:36,920
THAT TEND TO SUBVERT THE NORMAL 

2849
02:20:36,920 --> 02:20:39,600
PROCESS AND ALLOW US TO MOVE 

2850
02:20:39,600 --> 02:20:42,560
FORWARD MORE RAPIDLY.

2851
02:20:42,560 --> 02:20:45,680
I'D LOVE TO SEE NIH THINK ABOUT 

2852
02:20:45,680 --> 02:21:07,760
[AUDIO DIGITIZING]

2853
02:21:07,760 --> 02:21:07,880
 

2854
02:21:07,880 --> 02:21:10,760
>> WE'RE LOSING YOU A BIT.

2855
02:21:10,760 --> 02:21:12,800
>> THE GENERAL STATEMENT IS WE 

2856
02:21:12,800 --> 02:21:17,560
USE BIBLIOMETRICS AS A MEASURE 

2857
02:21:17,560 --> 02:21:18,040
IN TIMES FOR HIRING AND 

2858
02:21:18,040 --> 02:21:22,840
PROMOTION.

2859
02:21:22,840 --> 02:21:24,240
MEASURES COME FROM BUSINESSES 

2860
02:21:24,240 --> 02:21:25,400
NOT ACADEMIA.

2861
02:21:25,400 --> 02:21:26,960
CELL PRESS AND NATURE PRESS ARE 

2862
02:21:26,960 --> 02:21:29,920
BUSINESSES AND WE'VE HANDED OVER

2863
02:21:29,920 --> 02:21:36,560
TO THEM A PROXY THAT WE THEN USE

2864
02:21:36,560 --> 02:21:39,760
FOR HIRING AND MY SUSPICION IS 

2865
02:21:39,760 --> 02:21:43,320
THIS PARTICULAR MEASUREMENT IS 

2866
02:21:43,320 --> 02:21:45,520
USED TO SELECTIVELY DAMAGE THE 

2867
02:21:45,520 --> 02:21:47,720
CHANCES OF THOSE THAT FALL IN 

2868
02:21:47,720 --> 02:21:48,960
THE DEI SECTOR.

2869
02:21:48,960 --> 02:21:50,440
I DON'T HAVE EVIDENCE FOR THIS 

2870
02:21:50,440 --> 02:21:54,240
BUT CERTAINLY THE LONGER YOU 

2871
02:21:54,240 --> 02:21:57,480
LIVE, LIKE ME, THE BETTER YOUR H

2872
02:21:57,480 --> 02:21:58,880
FACTOR IS AND THE PEOPLE WHO 

2873
02:21:58,880 --> 02:22:00,720
LIVED LONGEST SO FAR TEND TO BE 

2874
02:22:00,720 --> 02:22:03,400
OLD WHITE MALES IN ACADEMIA.

2875
02:22:03,400 --> 02:22:09,520
SO MY PROPOSAL IS THAT NIH USE 

2876
02:22:09,520 --> 02:22:12,480
ITS CONSIDERABLE POWER TO 

2877
02:22:12,480 --> 02:22:14,360
DEINCENTIVIZING THE USE OF 

2878
02:22:14,360 --> 02:22:16,480
BIBLIOMETRICS IN ALL FORMS OF 

2879
02:22:16,480 --> 02:22:20,480
ACADEMIC HIRING AND ADVANCEMENT.

2880
02:22:20,480 --> 02:22:21,440
>> THANK YOU.

2881
02:22:21,440 --> 02:22:23,400
>> I LOVE HEARING FROM 

2882
02:22:23,400 --> 02:22:23,840
DISRUPTORS.

2883
02:22:23,840 --> 02:22:25,120
THAT'S THE WHOLE INTENT.

2884
02:22:25,120 --> 02:22:27,000
WE WANTED TO HEAR FROM LOTS OF 

2885
02:22:27,000 --> 02:22:28,840
VOICES AND VIEW POINTS.

2886
02:22:28,840 --> 02:22:33,040
I WILL SAY THAT THE IRISH THAT 

2887
02:22:33,040 --> 02:22:34,800
YOU'RE RAISING ABOUT THE IMPACT 

2888
02:22:34,800 --> 02:22:38,360
FACTORS, ETCETERA, POTENTIALLY 

2889
02:22:38,360 --> 02:22:39,600
DISADVANTAGING CERTAIN GROUPS WE

2890
02:22:39,600 --> 02:22:43,560
DO HAVE DATA THAT WOULD SUGGEST 

2891
02:22:43,560 --> 02:22:47,560
THAT'S TRUE.

2892
02:22:47,560 --> 02:22:49,320
FROM THE STANDPOINT OF OUR 

2893
02:22:49,320 --> 02:22:53,000
EXTRAMURAL RESEARCH DID A 

2894
02:22:53,000 --> 02:22:54,120
CAREFUL ANALYSIS OF AREAS OF 

2895
02:22:54,120 --> 02:22:57,680
FOCUS AND APPLICANTS FOR RO1 

2896
02:22:57,680 --> 02:23:00,200
GRANTS FOR RACE AND ETHNICITY 

2897
02:23:00,200 --> 02:23:02,120
AND FOR INSTANCE FOR AFRICAN 

2898
02:23:02,120 --> 02:23:03,400
AMERICAN BLACK SCIENTISTS.

2899
02:23:03,400 --> 02:23:05,840
ABOUT 50% OF THEIR SUBJECT AREAS

2900
02:23:05,840 --> 02:23:08,120
FOCUSSED IN 13 DIFFERENT TOPICS 

2901
02:23:08,120 --> 02:23:13,640
THAT SKEWED TOWARDS PLACES LIKE 

2902
02:23:13,640 --> 02:23:16,880
THE NATIONAL INSTITUTE OF 

2903
02:23:16,880 --> 02:23:17,920
MINORITY HEALTH AND HEALTH 

2904
02:23:17,920 --> 02:23:21,040
DISPARITY RESEARCH.

2905
02:23:21,040 --> 02:23:24,280
WE KNOW IT DOESN'T GET AS HIGH 

2906
02:23:24,280 --> 02:23:26,280
IMPACT FACTOR AS A BASIC FOCUS 

2907
02:23:26,280 --> 02:23:26,560
STUDY.

2908
02:23:26,560 --> 02:23:30,520
I WILL ALSO SAY SOME OF OUR 

2909
02:23:30,520 --> 02:23:35,840
UNITE MEMBERS MADE OUTREACH TO 

2910
02:23:35,840 --> 02:23:38,520
NATURE EDITORS TO TALK ABOUT THE

2911
02:23:38,520 --> 02:23:41,040
ISSUE AND WHO IS ON THEIR REVIEW

2912
02:23:41,040 --> 02:23:41,280
PANELS.

2913
02:23:41,280 --> 02:23:43,440
THEY LISTENED, AT LEAST.

2914
02:23:43,440 --> 02:23:45,080
THEY CAME, THEY TALKED AND 

2915
02:23:45,080 --> 02:23:47,880
THEY'VE HAD OTHER INTERACTIONS 

2916
02:23:47,880 --> 02:23:49,320
WITH US BUT AGAIN CULTURE CHANGE

2917
02:23:49,320 --> 02:23:50,040
IS SLOW.

2918
02:23:50,040 --> 02:23:55,120
WE HAVE TO KEEP WORK AT IT.

2919
02:23:55,120 --> 02:23:56,080
>> RG.

2920
02:23:56,080 --> 02:24:01,640
>> I THINK THIS IS A VERY 

2921
02:24:01,640 --> 02:24:03,560
IMPORTANT POINT.

2922
02:24:03,560 --> 02:24:06,400
AND ALL OF THESE PUBLICATIONS 

2923
02:24:06,400 --> 02:24:13,640
ARE -- AT LEAST MOST OF THEM AND

2924
02:24:13,640 --> 02:24:16,480
INCREASINGLY OWNED BY BIG 

2925
02:24:16,480 --> 02:24:17,840
BUSINESSES AND I AGREE WITH 

2926
02:24:17,840 --> 02:24:23,200
TRYING TO GET AWAY FROM THINGS 

2927
02:24:23,200 --> 02:24:30,000
LIKE H FACTOR AND SO ON.

2928
02:24:30,000 --> 02:24:31,440
THERE'S OTHER METRICS LIKE 

2929
02:24:31,440 --> 02:24:34,160
NUMBER OF DOWNLOADS AND NUMBER 

2930
02:24:34,160 --> 02:24:36,240
OF TWEETS ABOUT AN ARTICLE AND 

2931
02:24:36,240 --> 02:24:40,640
SO ON THAT MAY BE MUCH MORE FAIR

2932
02:24:40,640 --> 02:24:47,560
AND MAY ENCOURAGE A MUCH MORE 

2933
02:24:47,560 --> 02:24:53,440
DIVERSE OR MORE EQUITY ACROSS 

2934
02:24:53,440 --> 02:24:55,800
EVEN TOPICS, AS YOU MENTIONED, 

2935
02:24:55,800 --> 02:24:58,240
THINGS LIKE HEALTH DISPARITIES 

2936
02:24:58,240 --> 02:24:59,680
MAY NOT BE CITED AS MUCH BUT MAY

2937
02:24:59,680 --> 02:25:03,040
BE TWEETED MORE AND DOWNLOADED 

2938
02:25:03,040 --> 02:25:05,280
QUITE A BIT AND MAINLY TO PUBLIC

2939
02:25:05,280 --> 02:25:07,720
POLICY ALL OF WHICH ARE PART OF 

2940
02:25:07,720 --> 02:25:08,040
METRICS.

2941
02:25:08,040 --> 02:25:11,600
I DO THINK THAT ONE THING THAT 

2942
02:25:11,600 --> 02:25:17,960
HAS REALLY HELPED IS NIH'S 

2943
02:25:17,960 --> 02:25:19,360
INSISTENCE THAT PUBLICATIONS ARE

2944
02:25:19,360 --> 02:25:22,640
MADE PUBLICLY AVAILABLE THROUGH 

2945
02:25:22,640 --> 02:25:28,080
PUB MED CENTRAL BECAUSE THAT 

2946
02:25:28,080 --> 02:25:37,040
ALLOWS PEOPLE TO BE CITED AND 

2947
02:25:37,040 --> 02:25:38,280
INTERESTING ARTICLES GET OUT 

2948
02:25:38,280 --> 02:25:41,080
THERE AND ARE AVAILABLE TO THE 

2949
02:25:41,080 --> 02:25:41,320
PUBLIC.

2950
02:25:41,320 --> 02:25:42,400
I THINK THAT'S HELPED A LOT.

2951
02:25:42,400 --> 02:25:48,400
I THINK ONE CONCERN IS THAT MANY

2952
02:25:48,400 --> 02:25:52,640
JOURNALS NOW ARE REQUESTING AN 

2953
02:25:52,640 --> 02:25:54,880
ABSORBITANT COST TO PUT ARTICLES

2954
02:25:54,880 --> 02:26:00,440
IN PUB MED CENTRAL.

2955
02:26:00,440 --> 02:26:03,120
AND IT IS $3,000 AND $4,000 TO 

2956
02:26:03,120 --> 02:26:04,800
HAVE YOUR ARTICLE MADE PUBLICLY 

2957
02:26:04,800 --> 02:26:06,600
AVAILABLE AND OFTEN REQUIRE IT.

2958
02:26:06,600 --> 02:26:08,600
THEY DON'T ALLOW THE AUTHOR TO 

2959
02:26:08,600 --> 02:26:14,240
PUT IT IN PUB MED CENTRAL 

2960
02:26:14,240 --> 02:26:14,560
THEMSELVES.

2961
02:26:14,560 --> 02:26:23,600
SO THAT IS -- IT'S A HUGE COST 

2962
02:26:23,600 --> 02:26:26,040
AND I THINK REVIEW COMMITTEES 

2963
02:26:26,040 --> 02:26:29,040
HAVE FOUND FAULT FOR ASKING FOR 

2964
02:26:29,040 --> 02:26:33,480
$8,000 TO $10,000 A YEAR FOR 

2965
02:26:33,480 --> 02:26:34,640
PUBLICATION COST AND IT'S MORE 

2966
02:26:34,640 --> 02:26:36,760
THAN THAT IF YOU'RE PAYING FOR 

2967
02:26:36,760 --> 02:26:43,600
THE PUB MED CENTRAL FEES TO THE 

2968
02:26:43,600 --> 02:26:43,840
JOURNAL.

2969
02:26:43,840 --> 02:26:45,240
I KNOW NATIONAL HEALTH -- I 

2970
02:26:45,240 --> 02:26:47,960
CAN'T THINK OF THE NAME BUT IN 

2971
02:26:47,960 --> 02:26:50,520
GREAT BRITAIN THEY ACTUALLY 

2972
02:26:50,520 --> 02:26:54,640
COVER THESE COSTS FOR AUTHORS 

2973
02:26:54,640 --> 02:26:55,640
AND MAY BE SOMETHING NIH MAY 

2974
02:26:55,640 --> 02:26:58,120
WANT TO THINK ABOUT.

2975
02:26:58,120 --> 02:27:00,000
YOU CAN TAKE IT OUT OF YOUR 

2976
02:27:00,000 --> 02:27:03,400
GRANT BUT MOST PEOPLE HAVE NOT 

2977
02:27:03,400 --> 02:27:05,800
BEEN ABLE TO BUDGET ENOUGH TO 

2978
02:27:05,800 --> 02:27:07,640
COVER PUBLICATION COST THE 

2979
02:27:07,640 --> 02:27:08,880
PUBLIC ACCESS COST.

2980
02:27:08,880 --> 02:27:11,200
IT MAY BE SOMETHING THAT NIH 

2981
02:27:11,200 --> 02:27:14,040
COULD CONSIDER THAT WOULD 

2982
02:27:14,040 --> 02:27:17,520
IMPROVE ACCESS TO SCIENCE FROM 

2983
02:27:17,520 --> 02:27:19,560
ALL AUTHORS.

2984
02:27:19,560 --> 02:27:20,240
>> THANK YOU.

2985
02:27:20,240 --> 02:27:37,040
I'LL TAKE IT BACK TO COLLEAGUES.

2986
02:27:37,040 --> 02:27:40,720
  ALL RIGHT, ANY OTHER COMMENTS?

2987
02:27:40,720 --> 02:27:41,440
MARIE, THANK YOU SO MUCH.

2988
02:27:41,440 --> 02:27:43,040
OBVIOUSLY VERY STIMULATING AND A

2989
02:27:43,040 --> 02:27:43,680
LOT OF INTEREST.

2990
02:27:43,680 --> 02:27:44,840
I APPRECIATE ALL THE WORK THAT 

2991
02:27:44,840 --> 02:27:47,440
YOU DO AND LOOK FORWARD TO WHAT 

2992
02:27:47,440 --> 02:27:49,840
WE HAVE COMING AHEAD.

2993
02:27:49,840 --> 02:27:50,640
>> THANK YOU.

2994
02:27:50,640 --> 02:27:51,000
>> ALL RIGHT.

2995
02:27:51,000 --> 02:27:53,640
BYE-BYE.

2996
02:27:53,640 --> 02:27:54,000
>> ALL RIGHT.

2997
02:27:54,000 --> 02:27:59,520
SO WE'RE TO THE END OF OUR TIME.

2998
02:27:59,520 --> 02:28:00,680
WE'VE HAD A LOT OF FANTASTIC 

2999
02:28:00,680 --> 02:28:01,440
PRESENTATIONS AND I APPRECIATE 

3000
02:28:01,440 --> 02:28:06,080
ALL OF YOUR ENGAGEMENT AND 

3001
02:28:06,080 --> 02:28:08,480
INTEREST IN YOUR COMMENTS.

3002
02:28:08,480 --> 02:28:09,640
DOES ANYONE HAVE ANYONE YOU'D 

3003
02:28:09,640 --> 02:28:14,320
LIKE TO RAISE AS A FINAL POINT?

3004
02:28:14,320 --> 02:28:15,040
ALL RIGHT.

3005
02:28:15,040 --> 02:28:17,640
SO TOMORROW WE HAVE ANOTHER 

3006
02:28:17,640 --> 02:28:24,040
GREAT PROGRAM FOR A COUPLE 

3007
02:28:24,040 --> 02:28:25,240
HOURS.

3008
02:28:25,240 --> 02:28:30,400
WE'LL HEAR A REPORT ON OUR 

3009
02:28:30,400 --> 02:28:33,800
INCLUSIVE AND DIVERSITY EFFORTS.

3010
02:28:33,800 --> 02:28:35,480
WE'LL SEE YOU THEN.

3011
02:28:35,480 --> 02:28:36,880
ANY LAST WORDS, BECKY?

3012
02:28:36,880 --> 02:28:38,040
>> SEE YOU ALL TOMORROW AT 

3013
02:28:38,040 --> 02:28:38,240
10:00.

3014
02:28:38,240 --> 00:00:00,000
BYE.