1 00:00:05,760 --> 00:00:09,480 >>SESSION OF THE ADVISORY 2 00:00:09,480 --> 00:00:11,080 COMMITTEE TO THE NATIONAL 3 00:00:11,080 --> 00:00:13,120 INSTITUTE OF ALLERGY AND 4 00:00:13,120 --> 00:00:14,440 INFECTIOUS DISEASES, THIS AS 5 00:00:14,440 --> 00:00:16,400 YOU RECOGNIZE IS AN OPEN 6 00:00:16,400 --> 00:00:18,000 SESSION THIS MORNING SO WE'RE 7 00:00:18,000 --> 00:00:19,480 JOINED BY MEMBERS OF 8 00:00:19,480 --> 00:00:21,560 PROFESSIONAL AND LAY 9 00:00:21,560 --> 00:00:22,560 ORGANIZATIONS TO SHARE COMMON 10 00:00:22,560 --> 00:00:25,000 INTERESTS WITH OURS AND WE 11 00:00:25,000 --> 00:00:27,680 WELL WELCOME YOU AND SHARE 12 00:00:27,680 --> 00:00:29,200 YOUR PARTICIPATION. 13 00:00:29,200 --> 00:00:39,760 NOW, THERE ARE FIVE MEMBERS OF 14 00:00:44,720 --> 00:00:49,200 PROGRESS TO ATTEND THEIR 15 00:00:49,200 --> 00:00:53,640 SERVICE AND THIS GROUP OF FIVE 16 00:00:53,640 --> 00:00:54,960 WILL BE WORKING THROUGH 17 00:00:54,960 --> 00:00:57,120 JANUARY AND WE WILL MARK YOUR 18 00:00:57,120 --> 00:00:59,840 PICTURES AT THE END OF THE 19 00:00:59,840 --> 00:01:01,800 OPEN SESSION SO STAY TUNED, WE 20 00:01:01,800 --> 00:01:04,040 HAVE PLAQUES FOR YOU, ET 21 00:01:04,040 --> 00:01:04,760 CETERA. 22 00:01:04,760 --> 00:01:07,200 WE HAVE FLEE ADHOC MEMBERS OF 23 00:01:07,200 --> 00:01:09,120 COUNCIL TODAY AND I AM PLEASED 24 00:01:09,120 --> 00:01:14,120 ALL THREE OF THEM CAN USE THE 25 00:01:14,120 --> 00:01:15,480 WORD TRANSPLANTATION WHEN IT 26 00:01:15,480 --> 00:01:21,640 COMES TO WHAT THEY DO AND TWO 27 00:01:21,640 --> 00:01:23,840 OF THEM COME FROM SURGERY SO 28 00:01:23,840 --> 00:01:26,440 WELCOME TO ALL THREE OF THEM. 29 00:01:26,440 --> 00:01:27,800 THEY ALL HAVE DISTINGUISHED 30 00:01:27,800 --> 00:01:29,160 RECORDS BUT I THINK THIS MAY 31 00:01:29,160 --> 00:01:30,800 BE THE FIRST TIME WE HAVE A 32 00:01:30,800 --> 00:01:32,480 MEMBER SERVING ON COUNCIL WHO 33 00:01:32,480 --> 00:01:33,600 IS IN THE BEGIN NET BOOK OF 34 00:01:33,600 --> 00:01:34,160 WORLD RECORDS. 35 00:01:34,160 --> 00:01:36,360 ROBERT IS RESPONSIBLE FOR 36 00:01:36,360 --> 00:01:38,040 EIGHT TRANSPLANTS ORGANIZED IN 37 00:01:38,040 --> 00:01:40,880 A CERTAIN DAY WHICH HE 38 00:01:40,880 --> 00:01:42,480 WITNESSED A DOMINO TRANSPLANT 39 00:01:42,480 --> 00:01:44,560 WHERE YOU TAKE ATTORNEYS AND 40 00:01:44,560 --> 00:01:47,080 PATIENTS AND SWITCH THEM UP 41 00:01:47,080 --> 00:01:49,040 WITH OTHERS FOR A SEQUENCE 42 00:01:49,040 --> 00:01:51,560 THAT ENABLES THEM TO RECEIVE 43 00:01:51,560 --> 00:01:53,400 ORGANS AND THAT WAS ONLY ONE 44 00:01:53,400 --> 00:01:57,400 OF A NUMBER OF INCREDIBLE 45 00:01:57,400 --> 00:02:00,640 THINGS THAT HE HAS DONE SO 46 00:02:00,640 --> 00:02:01,240 WELCOME. 47 00:02:01,240 --> 00:02:02,720 OUR FIRST ORDER OF BUSINESS IS 48 00:02:02,720 --> 00:02:06,600 TO APPROVE THE MINUTES OF MY 49 00:02:06,600 --> 00:02:07,520 LAST MEETING. 50 00:02:07,520 --> 00:02:10,680 THE MINUTES SHOULD BE IN YOUR 51 00:02:10,680 --> 00:02:13,800 COUNCIL ELECTRONIC BOOKS. 52 00:02:13,800 --> 00:02:15,560 ANY QUESTIONS, COMMENTS OR 53 00:02:15,560 --> 00:02:20,480 DIRECTIONS AS TO THE MINUTES 54 00:02:20,480 --> 00:02:22,640 THE COUNCIL HAD AT LAST 55 00:02:22,640 --> 00:02:23,920 SESSION, LET ME KNOW, 56 00:02:23,920 --> 00:02:26,720 OTHERWISE CAN I HAVE A MOTION 57 00:02:26,720 --> 00:02:29,480 TO APPROVE THE MINUTES. 58 00:02:29,480 --> 00:02:33,680 SECONDED, ALL IN FAVOR, AYE, 59 00:02:33,680 --> 00:02:35,320 ANY OPPOSED, THANK YOU, 60 00:02:35,320 --> 00:02:38,680 ANDREA, THE MINUTES ARE NOW 61 00:02:38,680 --> 00:02:39,040 APPROVED. 62 00:02:39,040 --> 00:02:40,360 BIG ANNOUNCEMENT. 63 00:02:40,360 --> 00:02:41,680 THIS IS OUR BIGGEST 64 00:02:41,680 --> 00:02:42,480 ANNOUNCEMENT. 65 00:02:42,480 --> 00:02:47,800 YOU ARE PROBABLY AWARE THAT 66 00:02:47,800 --> 00:02:52,920 JENNY HAS BEEN ANNOUNCED AS 67 00:02:52,920 --> 00:03:03,400 THE NEXT NIAI ID DIRECTOR, 68 00:03:05,560 --> 00:03:16,040 BEEN DIRECTOR AT UNIVERSITY OF 69 00:03:20,480 --> 00:03:22,920 ALABAMA, PHYSICIANS IN TENURE 70 00:03:22,920 --> 00:03:26,280 TRACK, ON THE BOARD OF NSA AND 71 00:03:26,280 --> 00:03:28,920 WELL QUALITY FIGHT TO BE OUR 72 00:03:28,920 --> 00:03:31,400 NEW DIRECTOR AND WE CAN'T WAIT 73 00:03:31,400 --> 00:03:32,360 TO WELCOME HER HERE. 74 00:03:32,360 --> 00:03:35,120 WE WANT TO BRING HER IN 75 00:03:35,120 --> 00:03:37,560 SPLENDOR SO WE'RE PREPARING 76 00:03:37,560 --> 00:03:39,400 HER OFFICE FOR HER AND IT 77 00:03:39,400 --> 00:03:40,760 LOOKS LIKE THIS AT THIS POINT. 78 00:03:40,760 --> 00:03:45,640 THOSE OF YOU WHO HAVE SEEN 79 00:03:45,640 --> 00:03:46,720 Dr. FAUCI''S OFFICE IN THE 80 00:03:46,720 --> 00:03:48,320 PAST, THIS IS WHAT IT LOOKS 81 00:03:48,320 --> 00:03:48,640 LIKE. 82 00:03:48,640 --> 00:03:51,000 AND THEN IF YOU TURNED AROUND 83 00:03:51,000 --> 00:03:52,880 AND LOOKED AS WHERE MY OLD 84 00:03:52,880 --> 00:03:55,880 OFFICE USED TO BE, IT LOOKS 85 00:03:55,880 --> 00:03:57,760 EXACTLY LIKE THIS AS WELL. 86 00:03:57,760 --> 00:04:01,480 THE GOOD NEWS IS THE ASBESTOS 87 00:04:01,480 --> 00:04:01,800 IS GONE. 88 00:04:01,800 --> 00:04:05,160 THE BAD NEWS IS THE RENOVATION 89 00:04:05,160 --> 00:04:08,160 ITSELF ON THE BE COMPLETED 90 00:04:08,160 --> 00:04:09,880 TILL 204 SO DON'T HOLD YOUR 91 00:04:09,880 --> 00:04:10,800 BREATH. 92 00:04:10,800 --> 00:04:12,400 IN THE MEANWHILE, ALL OF US 93 00:04:12,400 --> 00:04:14,720 HAVE MOVED TO THE OPPOSITE END 94 00:04:14,720 --> 00:04:18,640 OF THE FLOOR IN CUBBY HOLES SO 95 00:04:18,640 --> 00:04:22,720 IT WON'T REALLY BE REBOTTLE 96 00:04:22,720 --> 00:04:24,440 SPLENDOR WHEN SHE ARRIVES 97 00:04:24,440 --> 00:04:25,360 HERE. 98 00:04:25,360 --> 00:04:28,320 OVER THE WEEKEND, BERNIE 99 00:04:28,320 --> 00:04:31,320 SANDERS ANNOUNCED HE WILL HOLD 100 00:04:31,320 --> 00:04:35,320 CONFIRMATION HEARINGS FOR 101 00:04:35,320 --> 00:04:37,720 MONICA BERTAGNOLLI IN OCTOBER. 102 00:04:37,720 --> 00:04:40,320 THIS COMES FROM A CONTRACT 103 00:04:40,320 --> 00:04:44,520 THAT HAS A FARE PRICING CLAUSE 104 00:04:44,520 --> 00:04:47,600 IN IT SO IS AN INDICATOR TO 105 00:04:47,600 --> 00:04:50,320 HIM THAT WE'RE DOING SOMETHING 106 00:04:50,320 --> 00:04:52,360 TO CONTROL DRUG PRICES. 107 00:04:52,360 --> 00:04:54,160 I SUSPECT THE PERSON MOST 108 00:04:54,160 --> 00:04:57,200 EXCITED ABOUT THIS IS ACTUALLY 109 00:04:57,200 --> 00:04:58,320 LARRY TABAK. 110 00:04:58,320 --> 00:05:02,160 OTHER APPOINTMENTS AROUND THE 111 00:05:02,160 --> 00:05:03,840 GOVERNMENT, MANDY COHEN HAS 112 00:05:03,840 --> 00:05:07,240 TAKEN OVER AS CDC DIRECTOR, 113 00:05:07,240 --> 00:05:09,480 CHIEF OF STAFF AND CHIEF 114 00:05:09,480 --> 00:05:11,440 OPERATING OFFICER OUT OF THE 115 00:05:11,440 --> 00:05:13,440 CENTER FOR MEDICARE AND 116 00:05:13,440 --> 00:05:14,480 MEDICAID SERVICES. 117 00:05:14,480 --> 00:05:17,840 LET ME PUT THIS -- THIS IS 118 00:05:17,840 --> 00:05:20,360 UNDER THE OBAMA 119 00:05:20,360 --> 00:05:21,360 ADMINISTRATION. 120 00:05:21,360 --> 00:05:21,640 COHEN. 121 00:05:21,640 --> 00:05:24,320 LET ME PUT THIS IN PERSPECTIVE 122 00:05:24,320 --> 00:05:26,760 FOR YOU. 123 00:05:26,760 --> 00:05:28,360 THE BUDGET IS 1.4 TRILLION, 124 00:05:28,360 --> 00:05:31,880 THE BUDGET FOR CMS IS 125 00:05:31,880 --> 00:05:32,400 $1.3 TRILLION. 126 00:05:32,400 --> 00:05:37,960 SO THIS IS THE CENTER OF ACT 127 00:05:37,960 --> 00:05:40,880 ACTIVITY FOR HHS. 128 00:05:40,880 --> 00:05:44,120 MANDY COHEN WAS THE DIRECT 129 00:05:44,120 --> 00:05:45,320 DIRECTOR OF NORTH CAROLINA 130 00:05:45,320 --> 00:05:48,400 HEALTH AND HUMAN SERVICES 131 00:05:48,400 --> 00:05:50,600 RIGHT IN THE MIDST OF THE 132 00:05:50,600 --> 00:05:53,240 PANDEMIC SO SHE HAS HAD LOTS 133 00:05:53,240 --> 00:05:54,880 OF EXPERIENCE IN THE PUBLIC 134 00:05:54,880 --> 00:05:55,160 EYE. 135 00:05:55,160 --> 00:05:57,160 IN THE WHITE HOUSE, THERE IS 136 00:05:57,160 --> 00:06:01,240 NOW AN OFFICE OF NATIONAL 137 00:06:01,240 --> 00:06:05,880 PREPAREDNESS AND RESPONSE, 138 00:06:05,880 --> 00:06:07,920 THIS JUST AS STEVE WAS LEAVING 139 00:06:07,920 --> 00:06:13,120 AND WE NOW HAVE PAUL 140 00:06:13,120 --> 00:06:14,080 FRIEDRICHS ASSUMING THE 141 00:06:14,080 --> 00:06:14,840 OFFICE. 142 00:06:14,840 --> 00:06:16,520 HE IS A RETIRED MAJOR GENERAL 143 00:06:16,520 --> 00:06:18,720 IN THE AIR FORCE, AN MD. 144 00:06:18,720 --> 00:06:22,680 HE WAS THE SURGEON COMMAND IN 145 00:06:22,680 --> 00:06:24,000 THE JOINT STAFF. 146 00:06:24,000 --> 00:06:27,920 HE ALSO HAPPENS TO BE A HIGHLY 147 00:06:27,920 --> 00:06:29,760 DECK DECORATED FIGHTER COMBAT 148 00:06:29,760 --> 00:06:30,040 PILOT. 149 00:06:30,040 --> 00:06:32,120 I HAVEN'T EVER MET HIM BUT 150 00:06:32,120 --> 00:06:34,000 HAVE THE IMPRESSION YOU 151 00:06:34,000 --> 00:06:43,120 WOULDN'T WANT TO TANGLE WITH 152 00:06:43,120 --> 00:06:43,960 PAUL FRIEDRICHS. 153 00:06:43,960 --> 00:06:47,440 NOW WE'RE GOING TO HAVE ABOUT 154 00:06:47,440 --> 00:06:52,560 TEN OR 15 SLIDES ABOUT 155 00:06:52,560 --> 00:06:55,960 PROMOTIONS HERE AT NIAID AND 156 00:06:55,960 --> 00:06:56,400 NIH. 157 00:06:56,400 --> 00:06:57,920 MANY OF THESE PEOPLE YOU WON'T 158 00:06:57,920 --> 00:06:59,720 KNOW BUT I THINK IT IS USEFUL 159 00:06:59,720 --> 00:07:01,520 FOR THE STAFF TO SEE THEIR 160 00:07:01,520 --> 00:07:02,880 COLLEAGUES AND PEERS AND 161 00:07:02,880 --> 00:07:04,840 USEFUL FOR COUNCIL MEMBERS TO 162 00:07:04,840 --> 00:07:09,480 GET A SNAP SNAPSHOT OF THE 163 00:07:09,480 --> 00:07:10,440 WORKFORCE. 164 00:07:10,440 --> 00:07:11,880 SO JANE SIMONI HAS BEEN 165 00:07:11,880 --> 00:07:13,440 SELECTED AS DIRECTOR OF THE 166 00:07:13,440 --> 00:07:15,560 OFFICE OF BEHAVIORAL AND 167 00:07:15,560 --> 00:07:17,160 SOCIAL SIGNS RESEARCH, NIH 168 00:07:17,160 --> 00:07:18,120 APPOINTMENT. 169 00:07:18,120 --> 00:07:21,320 SHE HAS AN EXTENSIVE 170 00:07:21,320 --> 00:07:22,480 BACKGROUND. 171 00:07:22,480 --> 00:07:26,560 IS A CLINICAL PSYCHOLOGIST BUT 172 00:07:26,560 --> 00:07:29,120 HAS A TROPICAL SYSTEM 173 00:07:29,120 --> 00:07:32,040 TREMENDOUSLY DOUSE AMOUNT OF 174 00:07:32,040 --> 00:07:34,520 WORK WITH HIV. 175 00:07:34,520 --> 00:07:36,680 ANOTHER ANNOUNCEMENT IS PATTY 176 00:07:36,680 --> 00:07:38,160 GRENNAN, DIRECTOR OF THE 177 00:07:38,160 --> 00:07:39,480 NATIONAL LIBRARY OF MEDICINE 178 00:07:39,480 --> 00:07:41,680 FOR SEVEN YEARS AND BEEN A 179 00:07:41,680 --> 00:07:44,760 BUNDLE OF ENERGY TO MAKE THE 180 00:07:44,760 --> 00:07:46,800 NATIONAL LIBRARY A GLOBAL 181 00:07:46,800 --> 00:07:48,480 RESEARCH LIBRARY FOR 182 00:07:48,480 --> 00:07:49,760 EVERYBODY. 183 00:07:49,760 --> 00:07:51,280 MOVING INTO NIAID 184 00:07:51,280 --> 00:07:52,640 APPOINTMENTS, KELLY POE HAS 185 00:07:52,640 --> 00:07:55,680 BEEN NAMED AS DIRECTOR OF THE 186 00:07:55,680 --> 00:07:57,360 DIVISION OF INTRAMURAL 187 00:07:57,360 --> 00:07:57,800 ACTIVITIES. 188 00:07:57,800 --> 00:08:02,320 KELLY CAME TO NIH TO BE 189 00:08:02,320 --> 00:08:03,800 DIRECTOR OF INTRAMURAL 190 00:08:03,800 --> 00:08:06,320 ACTIVITIES AS SCIENTIFIC 191 00:08:06,320 --> 00:08:07,600 REVIEW DIRECTOR, BECAME THE 192 00:08:07,600 --> 00:08:11,080 DEPUTY DIRECTOR OF THE REVIEW 193 00:08:11,080 --> 00:08:12,360 PROGRAM, BECAME DEPUTY 194 00:08:12,360 --> 00:08:15,080 DIRECTOR OF DA AND ACTING 195 00:08:15,080 --> 00:08:17,400 DIRECTOR OF DEA AND NOW 196 00:08:17,400 --> 00:08:19,360 FINALLY THE ACTUAL DIRECTOR OF 197 00:08:19,360 --> 00:08:19,880 DEA. 198 00:08:19,880 --> 00:08:21,760 IT IS A TERRIFIC APPOINTMENT 199 00:08:21,760 --> 00:08:23,080 FOR ALL OF US. 200 00:08:23,080 --> 00:08:28,080 WE HAD TO TWIST SOME ARMS TO 201 00:08:28,080 --> 00:08:30,720 GET ANDREA TO SERVE AS ACTING 202 00:08:30,720 --> 00:08:31,320 DIRECTOR. 203 00:08:31,320 --> 00:08:37,240 SHE CAME TO NIH AND NIAID IN 204 00:08:37,240 --> 00:08:38,960 2011 AND WHENEVER I NEED TO 205 00:08:38,960 --> 00:08:41,360 KNOW WHAT IS SUPPOSED TO 206 00:08:41,360 --> 00:08:45,760 HAPPEN IN DEA, I CALL UP 207 00:08:45,760 --> 00:08:48,800 ANDREA WURSTER AND SHE ALWAYS 208 00:08:48,800 --> 00:08:52,200 KNOWS THE ANSWER. 209 00:08:52,200 --> 00:09:00,120 THE DIRECTOR OF THE OFFICE OF 210 00:09:00,120 --> 00:09:05,760 DATA SCIENCE AND EMERGING 211 00:09:05,760 --> 00:09:07,040 TECHNOLOGIES, SH ABMAN 212 00:09:07,040 --> 00:09:08,200 SELECTED AS DEPUTY DIRECTOR 213 00:09:08,200 --> 00:09:14,280 AND A GOOD ADDITION HERE. 214 00:09:14,280 --> 00:09:16,360 AN EXPERIENCED PEDIATRICIAN 215 00:09:16,360 --> 00:09:18,560 OVERSEAING CLINICAL TRIALS IN 216 00:09:18,560 --> 00:09:21,320 D IRA IDS FOR YEARS, THIS WILL 217 00:09:21,320 --> 00:09:26,960 BE A TERRIFIC APPOINTMENT FOR 218 00:09:26,960 --> 00:09:28,280 AIM KNEE YEN. 219 00:09:28,280 --> 00:09:33,200 NOW, PEOPLE ASK ME WHAT IS 220 00:09:33,200 --> 00:09:33,640 OSPIDA. 221 00:09:33,640 --> 00:09:37,960 IT IS THE OFFICE OF STRATEGIC 222 00:09:37,960 --> 00:09:39,160 PLANNING, INITIAL DEVELOPMENT 223 00:09:39,160 --> 00:09:41,760 AND ANALYSIS BUT I STILL DON'T 224 00:09:41,760 --> 00:09:44,720 KNOW WHAT THEY DO. 225 00:09:44,720 --> 00:09:45,960 I ASKED JOHANNA SCHNEIDER WHAT 226 00:09:45,960 --> 00:09:49,160 IS IT YOU DO AND SHE SAID WE 227 00:09:49,160 --> 00:09:51,280 ARE THE DEEP STATE OF NIAID. 228 00:09:51,280 --> 00:09:53,640 NOBODY KNOWS WHAT WE DO BUT WE 229 00:09:53,640 --> 00:09:54,320 GET IT DONE. 230 00:09:54,320 --> 00:09:55,440 INDEED I WANT TO MENTION THAT 231 00:09:55,440 --> 00:09:59,920 ONE OF THE PEOPLE WHO WORKS IN 232 00:09:59,920 --> 00:10:02,760 OSPI IDA IS LAURA MILLER WHO 233 00:10:02,760 --> 00:10:04,880 WAS GIVEN THE ASSIGNMENT TO 234 00:10:04,880 --> 00:10:07,120 PREPARE THE SLIDES AND 235 00:10:07,120 --> 00:10:08,160 BACKGROUND MATERIAL FOR MY 236 00:10:08,160 --> 00:10:09,640 COMMENTS THIS MORNING AND I 237 00:10:09,640 --> 00:10:12,560 APPRECIATE THE EFFORT YOU PUT 238 00:10:12,560 --> 00:10:14,520 IN, WORKING THROUGHOUT THE 239 00:10:14,520 --> 00:10:17,160 WEEKEND AS I MADE CHANGES IN 240 00:10:17,160 --> 00:10:20,400 THE SLIDES SO THANK YOU, 241 00:10:20,400 --> 00:10:23,560 ANOTHER OSPIDA FUNCTION. 242 00:10:23,560 --> 00:10:27,000 RESEARCH AND ANALYTICS BRANCH, 243 00:10:27,000 --> 00:10:29,880 JOHN NIE E AND CHIEF AND 244 00:10:29,880 --> 00:10:31,040 ANALYSIS BRANCH BRENDA LEE AND 245 00:10:31,040 --> 00:10:36,760 THAT WILL BE A PROMOTION FOR 246 00:10:36,760 --> 00:10:39,440 HER WITHIN THE ORGANIZATION. 247 00:10:39,440 --> 00:10:45,200 NOW A TRANSITION IN JULY WE 248 00:10:45,200 --> 00:10:55,720 RELUCTANTLY CELEBRATED THE 249 00:11:01,520 --> 00:11:01,960 RETIREMENT. 250 00:11:01,960 --> 00:11:03,600 WENT ON FOR PAGES AND I 251 00:11:03,600 --> 00:11:07,000 COULDN'T GET THROUGH ALL OF 252 00:11:07,000 --> 00:11:17,520 THEM BUT WHILE THE PANDEMIC 253 00:11:19,960 --> 00:11:22,920 STUDY -- -- WAS GOING ON, 254 00:11:22,920 --> 00:11:26,960 COMPLETED THE STUDY AND THE 255 00:11:26,960 --> 00:11:30,000 CHILDREN'S NETWORK, MARY WAS 256 00:11:30,000 --> 00:11:30,880 GIVEN ENORMOUS RESPONSIBILITY 257 00:11:30,880 --> 00:11:32,880 TO MAKE THAT HAPPEN. 258 00:11:32,880 --> 00:11:37,120 THERE WERE A NUMBER OF PEOPLE 259 00:11:37,120 --> 00:11:39,840 WITHIN NIAID WHO WORKED 260 00:11:39,840 --> 00:11:42,120 INCREDIBLY HARD AND NOBODY 261 00:11:42,120 --> 00:11:48,960 WORKED HARDER IN MY MIND THAN 262 00:11:48,960 --> 00:11:50,480 MARY MARAVICH, ACTING DIRECTOR 263 00:11:50,480 --> 00:11:53,520 OF THE RESEARCH PROGRAM. 264 00:11:53,520 --> 00:11:56,440 MARK WILL BE RETIRING AS THE 265 00:11:56,440 --> 00:12:07,200 CHIEF OF VILLAGE BRAN V -- -- 266 00:12:07,200 --> 00:12:08,920 VIROLOGY BRANCH, YOU HEARD 267 00:12:08,920 --> 00:12:10,400 ABOUT THESE PROGRAMS IN THE 268 00:12:10,400 --> 00:12:13,240 PAST BUT MARK WAS MAKING IT 269 00:12:13,240 --> 00:12:15,360 HAPPEN AND GENE WILL NOW BE 270 00:12:15,360 --> 00:12:18,880 ACTING DIRECTOR OF THE 271 00:12:18,880 --> 00:12:21,640 VIROLOGY BRANCH. 272 00:12:21,640 --> 00:12:26,080 THE HHS SECRETARY GIVEN TO 273 00:12:26,080 --> 00:12:28,560 JOHN BYVAL AND ALLEN POE. 274 00:12:28,560 --> 00:12:31,320 THESE TWO PEOPLE I THINK TIE 275 00:12:31,320 --> 00:12:33,480 MARY FOR HARD WORK DURING THE 276 00:12:33,480 --> 00:12:34,200 COVID RESPONSE. 277 00:12:34,200 --> 00:12:36,560 JOHN WAS FIRST OFF THE MARKET 278 00:12:36,560 --> 00:12:41,600 RUNNING A TREATMENT TRIAL FOR 279 00:12:41,600 --> 00:12:49,040 THIS COV2 VIRUS AND PROVING 280 00:12:49,040 --> 00:12:53,560 EARLY ON REMDESIVIR WAS 281 00:12:53,560 --> 00:12:55,440 EFFICIENT FOR IT AND HE WAS 282 00:12:55,440 --> 00:12:58,720 ONE OF THOSE WHO GOT THE STUDY 283 00:12:58,720 --> 00:12:59,080 DONE. 284 00:12:59,080 --> 00:13:01,800 THE TREATMENT GUIDELINES PANEL 285 00:13:01,800 --> 00:13:05,200 FOR COVID, THEY FIRST ISSUED 286 00:13:05,200 --> 00:13:07,800 THEIR GUIDANCE AND SINCE 287 00:13:07,800 --> 00:13:10,360 REVISED THEIR GUIDELINES AND 288 00:13:10,360 --> 00:13:15,280 UPGRADED THEM 68 TIMES AND THE 289 00:13:15,280 --> 00:13:17,800 SITE HAS RECEIVED 48 MILLION 290 00:13:17,800 --> 00:13:18,920 PAGE HITS OVER THE COURSE OF 291 00:13:18,920 --> 00:13:23,360 THE PAF TWO AND A HALF -- PAST 292 00:13:23,360 --> 00:13:26,080 TWO AND A HALF YEARS SO IT IS 293 00:13:26,080 --> 00:13:30,480 A STRIDE NARROW EFFORT AND SHE 294 00:13:30,480 --> 00:13:31,880 WAS CORRALLING TERRIFIC 295 00:13:31,880 --> 00:13:33,120 EFFORTS DURING THESE 296 00:13:33,120 --> 00:13:33,960 GUIDELINES. 297 00:13:33,960 --> 00:13:37,040 THEN A VERY SPECIAL AWARD FROM 298 00:13:37,040 --> 00:13:39,480 HHS AND A WORD FOR EXCELLENCE 299 00:13:39,480 --> 00:13:41,360 IN MANAGEMENT TO EMILY 300 00:13:41,360 --> 00:13:43,280 LENDING, CHIEF OF THE GRANTS 301 00:13:43,280 --> 00:13:44,560 MANAGEMENT PROGRAM. 302 00:13:44,560 --> 00:13:45,960 NOW, IF YOU HAVE TO IMAGINE 303 00:13:45,960 --> 00:13:50,080 OVER THE PAST THREE YEARS, WE 304 00:13:50,080 --> 00:13:51,840 RECEIVED AN ADDITIONAL 305 00:13:51,840 --> 00:13:52,680 $5 BILLION FOR OUR COVID 306 00:13:52,680 --> 00:13:55,760 RESPONSE WHICH MEANS A VERY 307 00:13:55,760 --> 00:13:58,240 HEAVILY PACKED BRANCH, THE 308 00:13:58,240 --> 00:14:00,760 BRANCH MANAGEMENT BRANCH, HAD 309 00:14:00,760 --> 00:14:03,160 A 50% INCREASE IN ITS WORKLOAD 310 00:14:03,160 --> 00:14:05,840 OVER THE COURSE OF THE THREE 311 00:14:05,840 --> 00:14:06,120 YEARS. 312 00:14:06,120 --> 00:14:07,720 IN ADDITION TO THAT, I THINK 313 00:14:07,720 --> 00:14:10,040 AS WE MENTIONED LAST TIME, WE 314 00:14:10,040 --> 00:14:11,520 HAD THE COVID FUNDING 315 00:14:11,520 --> 00:14:12,600 RECESSION WHERE THE FUNDING 316 00:14:12,600 --> 00:14:15,120 WAS GOING TO BE REMOVED IF WE 317 00:14:15,120 --> 00:14:16,920 DIDN'T GET DOLLARS OUT THE 318 00:14:16,920 --> 00:14:19,320 DOOR WHICH REQUIRED REWRITING 319 00:14:19,320 --> 00:14:21,000 HUNDREDS OF MILLIONS OF 320 00:14:21,000 --> 00:14:22,320 DOLLARS OF GRANT ACTIONS TO 321 00:14:22,320 --> 00:14:25,000 GET ALL THE MONEY OUT THE DOOR 322 00:14:25,000 --> 00:14:27,600 ON AN ANNUAL SEQUENCE AND NOW 323 00:14:27,600 --> 00:14:28,240 FOLLOWING THAT, IMMEDIATELY 324 00:14:28,240 --> 00:14:30,920 HAD TO TURN INTO THE END OF 325 00:14:30,920 --> 00:14:32,640 YEAR CHAOS WHICH HAPPENS HERE 326 00:14:32,640 --> 00:14:39,440 IN AUGUST AND SEPTEMBER. 327 00:14:39,440 --> 00:14:43,160 EMILY LIND DEAND -- LINDY AND 328 00:14:43,160 --> 00:14:44,880 HER STAFF ARE THE MOST 329 00:14:44,880 --> 00:14:47,680 ESSENTIAL PEOPLE HERE AT 330 00:14:47,680 --> 00:14:47,960 NIAID. 331 00:14:47,960 --> 00:14:50,040 I REALLY DO NOT KNOW HOW WE 332 00:14:50,040 --> 00:14:52,200 WOULD FUNCTION IF WE DID NOT 333 00:14:52,200 --> 00:14:53,480 HAVE THEM AT THE REALM. 334 00:14:53,480 --> 00:14:56,160 THIS IS THE THIRD HIGHEST 335 00:14:56,160 --> 00:14:59,800 AWARD AWARDED BY THE SECRETARY 336 00:14:59,800 --> 00:15:03,240 HIMSELF AND TOTALLY DESERVED 337 00:15:03,240 --> 00:15:05,040 BY EMILY LINDY. 338 00:15:05,040 --> 00:15:06,880 OTHER THINGS GOING ON AROUND 339 00:15:06,880 --> 00:15:09,200 NIH, WE HAD A GROUNDBREAKING 340 00:15:09,200 --> 00:15:12,080 FOR THE NEW WING WHICH WILL BE 341 00:15:12,080 --> 00:15:13,720 FOR RAID RADIOLOGY, LABORATORY 342 00:15:13,720 --> 00:15:15,120 AND MEDS CITIZEN. 343 00:15:15,120 --> 00:15:20,080 SHE IS EVENTS ARE SOMETIMES 344 00:15:20,080 --> 00:15:21,760 HOKIE EVENTS BUT THIS ONE WAS 345 00:15:21,760 --> 00:15:22,240 NICE. 346 00:15:22,240 --> 00:15:25,160 I GET THAT EARLY -- I GET 347 00:15:25,160 --> 00:15:31,400 THERE EARLY, AS I WORKED FOR 348 00:15:31,400 --> 00:15:34,440 Dr. FAUCCI FOR YEARS, BUT I 349 00:15:34,440 --> 00:15:38,600 GET THAT EARLY AND THERE WAS 350 00:15:38,600 --> 00:15:44,680 TALK ABOUT HOW THEY WERE 351 00:15:44,680 --> 00:15:54,320 PETITIONING WARREN TO TAKE THE 352 00:15:54,320 --> 00:15:54,960 HOLD OFF THE CONFIRMATION 353 00:15:54,960 --> 00:15:55,640 HEARING. 354 00:15:55,640 --> 00:16:06,200 THERE ARE TWO RSIS -- ABOUT 355 00:16:08,240 --> 00:16:10,080 KNOWLEDGE FOR HEALTH LINK AND 356 00:16:10,080 --> 00:16:13,640 LIGHT AND OPTIMIZE HEALTH FOR 357 00:16:13,640 --> 00:16:15,240 ALL PEOPLE, IF YOU WANT TO 358 00:16:15,240 --> 00:16:18,960 CHOOSE TO COMMENT ON THIS, DO 359 00:16:18,960 --> 00:16:20,160 SO BY DECEMBER 24TH. 360 00:16:20,160 --> 00:16:24,040 THERE IS ALSO A RFI OUT TO 361 00:16:24,040 --> 00:16:26,080 COMMENT ON QUESTIONS POSED ON 362 00:16:26,080 --> 00:16:32,360 THE POSITIONS OF OUR DIRK AND 363 00:16:32,360 --> 00:16:33,600 CPO OVERSIGHT POLICIES. 364 00:16:33,600 --> 00:16:36,200 THE PASSION OF RFI PUT OUT 365 00:16:36,200 --> 00:16:39,160 SEVERAL QUESTIONS TO YOU BUT 366 00:16:39,160 --> 00:16:41,120 IT DOES NOT INCLUDE THE DRAFT 367 00:16:41,120 --> 00:16:42,240 OF THE PROPOSED DIVISIONS BUT 368 00:16:42,240 --> 00:16:46,560 I CAN TELL YOU THE SUMMARY OF 369 00:16:46,560 --> 00:16:46,880 THOSE. 370 00:16:46,880 --> 00:16:49,120 DUKE RESEARCH AND CONCERN USED 371 00:16:49,120 --> 00:16:52,320 TO TILL NOW INVOLVE 15 372 00:16:52,320 --> 00:16:54,320 PATHOGENS AND THE 7 DEADLY 373 00:16:54,320 --> 00:16:59,240 SINS AS WE CALLED THEM. 374 00:16:59,240 --> 00:17:00,840 PCO, PATHOGENS OF PANDEMIC 375 00:17:00,840 --> 00:17:05,320 POTENTIAL, THE THREE P'S, CARE 376 00:17:05,320 --> 00:17:05,760 AND OVERSIGHT. 377 00:17:05,760 --> 00:17:07,080 CO, OKAY, THAT HAS BEEN 378 00:17:07,080 --> 00:17:08,800 MODIFIED IN THE DRAFT FORM 379 00:17:08,800 --> 00:17:14,240 WHERE IT USED TO BE -- WE 380 00:17:14,240 --> 00:17:20,080 WOULD WORRY ABOUT ENHANS D 381 00:17:20,080 --> 00:17:25,520 PATHOGENS OF POTENTIAL -- 382 00:17:25,520 --> 00:17:29,400 PANDEMIC POTENTIAL OF 383 00:17:29,400 --> 00:17:30,880 INCREASED TRANSADMISSIBILITY 384 00:17:30,880 --> 00:17:35,760 AND HIGHLY LIKELY 385 00:17:35,760 --> 00:17:36,600 INCREASED VIRILENCE. 386 00:17:36,600 --> 00:17:40,040 THE NEW ONE SAYS MODERATE 387 00:17:40,040 --> 00:17:46,240 POTENTIAL OF INCREASED 388 00:17:46,240 --> 00:17:51,120 TRANSMISSIBILITY AND 389 00:17:51,120 --> 00:17:52,280 MODERATELY 390 00:17:52,280 --> 00:17:52,840 INCREASED VIRILENCE. 391 00:17:52,840 --> 00:17:54,920 I THINK THAT SHOWS YOU HOW WE 392 00:17:54,920 --> 00:17:55,720 HIGHLIGHT THIS RESEARCH. 393 00:17:55,720 --> 00:17:57,040 A COUPLE OF ACTIVITIES TO 394 00:17:57,040 --> 00:17:57,360 MENTION. 395 00:17:57,360 --> 00:18:07,880 WE HAD A NICE MEETING WITH 396 00:18:08,480 --> 00:18:09,440 DENISAGEORGI, SHE HAS WORKED 397 00:18:09,440 --> 00:18:11,080 IN A NUMBER OF POSITIONS BUT 398 00:18:11,080 --> 00:18:16,640 WILL NOW BE THE HEALTH PASSE 399 00:18:16,640 --> 00:18:19,520 OF INDIA AND I WILL BE HEADED 400 00:18:19,520 --> 00:18:22,800 OVER TO INDIA FOR THE HEALTH 401 00:18:22,800 --> 00:18:24,600 PASSION PROGRAM WHICH I THINK 402 00:18:24,600 --> 00:18:27,360 IS IN ITS 37TH YEAR AND LOOK 403 00:18:27,360 --> 00:18:31,000 FORWARD TO HOOKING UP WITH HER 404 00:18:31,000 --> 00:18:31,280 THERE. 405 00:18:31,280 --> 00:18:32,920 WE ALSO HAVE HEALTH AND 406 00:18:32,920 --> 00:18:33,800 SCIENCE TECHNOLOGY. 407 00:18:33,800 --> 00:18:37,120 YOU ARE PROBABLY AWARE THAT 408 00:18:37,120 --> 00:18:39,320 HIGH-LEVEL WORK OF THE UNITED 409 00:18:39,320 --> 00:18:42,240 STATES HAS BEEN DONE IN CHINA 410 00:18:42,240 --> 00:18:46,520 OVER THE LAST YEARS AND HAS 411 00:18:46,520 --> 00:18:49,880 BEEN A VISIT LAST MAY OF 412 00:18:49,880 --> 00:18:51,040 DEPUTY DIRECTOR HSU WHO CAME 413 00:18:51,040 --> 00:18:54,520 TO SEE US AT NIAID AND I THINK 414 00:18:54,520 --> 00:18:57,240 THAT MAY BE AS HIGH A LEVEL 415 00:18:57,240 --> 00:18:58,640 FROM A CHINESE GOVERNMENT 416 00:18:58,640 --> 00:19:00,280 OFFICIAL FOR THE PAST SEVERAL 417 00:19:00,280 --> 00:19:00,600 YEARS. 418 00:19:00,600 --> 00:19:02,680 WE CONTINUE TO HAVE EVERY 419 00:19:02,680 --> 00:19:06,480 OTHER MONTH CALLS WITH 420 00:19:06,480 --> 00:19:07,600 SCIENTISTS -- MINISTRY OF 421 00:19:07,600 --> 00:19:09,560 SCIENCE AND TECHNOLOGY WITH 422 00:19:09,560 --> 00:19:12,520 OUR SCIENTISTS JOINING THEM SO 423 00:19:12,520 --> 00:19:13,560 THAT CONTACT CONTINUES 424 00:19:13,560 --> 00:19:14,600 OBVIOUSLY WITH THE KNOWLEDGE 425 00:19:14,600 --> 00:19:18,080 AND BLESSING OF OUR STATE 426 00:19:18,080 --> 00:19:18,480 DEPARTMENT. 427 00:19:18,480 --> 00:19:18,920 BUDGET UPDATE. 428 00:19:18,920 --> 00:19:20,600 THIS IS NOT GOING TO BE GOOD. 429 00:19:20,600 --> 00:19:22,680 THIS IS THE BUDGET WE'RE 430 00:19:22,680 --> 00:19:25,800 CURRENTLY LIVING WITH IN 431 00:19:25,800 --> 00:19:26,440 FISCAL YEAR '23. 432 00:19:26,440 --> 00:19:29,880 THERE WAS A INCREASE OF ONLY 433 00:19:29,880 --> 00:19:32,040 3.8 PERCENT WHICH WAS LESS 434 00:19:32,040 --> 00:19:33,800 THAN OTHER INSTITUTES WHICH 435 00:19:33,800 --> 00:19:35,080 WAS REALLY IRRITATING COMING 436 00:19:35,080 --> 00:19:37,080 OFF THE END OF THE PANDEMIC, 437 00:19:37,080 --> 00:19:37,920 NONETHELESS, IT WAS AN 438 00:19:37,920 --> 00:19:40,800 INCREASE AND WE WERE ABLE TO 439 00:19:40,800 --> 00:19:41,400 CONTINUE FUNCTIONING. 440 00:19:41,400 --> 00:19:43,000 THIS IS A PICTURE I THINK I 441 00:19:43,000 --> 00:19:46,480 HAVE SHOWN YOU BEFORE, NIAID 442 00:19:46,480 --> 00:19:48,960 IN RELATIVE TERMS, THE SECOND 443 00:19:48,960 --> 00:19:50,960 LARGEST OF THE NIH INSTITUTES. 444 00:19:50,960 --> 00:19:53,240 WHILE I HAVE BEEN HERE, THE 445 00:19:53,240 --> 00:19:55,320 CIRCLE IN THE UPPER RIGHT OD, 446 00:19:55,320 --> 00:19:57,720 OFFICE OF THE DIRECTOR, HAS 447 00:19:57,720 --> 00:19:59,680 GONE FROM BEING THE SIZE THERE 448 00:19:59,680 --> 00:20:01,040 ON THE LEFTHAND SIDE WITH THE 449 00:20:01,040 --> 00:20:04,800 GREEN DO THE OF THE FOGGARTY 450 00:20:04,800 --> 00:20:06,560 CENTER, THAT WAS THE SIZE OF 451 00:20:06,560 --> 00:20:08,800 THE DIRECTOR WHEN I GOT HERE, 452 00:20:08,800 --> 00:20:10,880 YOU CAN SEE ITS SIZE AT THIS 453 00:20:10,880 --> 00:20:11,560 POINT. 454 00:20:11,560 --> 00:20:13,280 THE OTHER BIG GROWTH AREA HAS 455 00:20:13,280 --> 00:20:14,840 WITHIN THE NATIONAL INSTITUTE 456 00:20:14,840 --> 00:20:18,200 OF AGING IN PINK WHICH OF 457 00:20:18,200 --> 00:20:20,480 COURSE AS BABY BOOMERS GET 458 00:20:20,480 --> 00:20:23,960 OLDER, THERE IS INCREASED 459 00:20:23,960 --> 00:20:25,160 ACTIVITY AT ANY NIH. 460 00:20:25,160 --> 00:20:28,480 NOW THIS IS A PICTURE OF NIAID 461 00:20:28,480 --> 00:20:30,880 FUNDING OVER THE PAST 20 OR SO 462 00:20:30,880 --> 00:20:31,480 YEARS. 463 00:20:31,480 --> 00:20:34,600 I GOT HERE, I THINK, IN 2006 464 00:20:34,600 --> 00:20:38,400 AND YOU CAN SEE WE HAD A 465 00:20:38,400 --> 00:20:39,200 PROLONGED PERIOD OF FLAT 466 00:20:39,200 --> 00:20:40,680 BUDGETS WHICH OF COURSE WAS 467 00:20:40,680 --> 00:20:42,920 NOT REALLY FLAT WHEN YOU 468 00:20:42,920 --> 00:20:44,280 FACTOR IN INFLATION. 469 00:20:44,280 --> 00:20:45,880 THE LAST EIGHT YEARS HAVE BEEN 470 00:20:45,880 --> 00:20:47,520 PRETTY GOOD SO YOU HAVE SEEN 471 00:20:47,520 --> 00:20:48,920 THE INCREASES OVER THAT PERIOD 472 00:20:48,920 --> 00:20:49,840 OF TIME. 473 00:20:49,840 --> 00:20:51,320 THE DISTURBING NUMBER IS THE 474 00:20:51,320 --> 00:20:54,760 LAST ONE WITH THE PRESIDENT'S 475 00:20:54,760 --> 00:20:57,440 BUDGET REQUEST FOR 2024 WHICH 476 00:20:57,440 --> 00:20:59,560 IS FLAT. 477 00:20:59,560 --> 00:21:03,560 THAT IS COMING FROM THE BIDEN 478 00:21:03,560 --> 00:21:05,480 ADMINISTRATION AND A 479 00:21:05,480 --> 00:21:06,120 DEMOCRATIC ADMINISTRATION. 480 00:21:06,120 --> 00:21:11,560 WE WERE USED TO SEEING A 481 00:21:11,560 --> 00:21:14,360 BUDGET UNDER PRESIDENT TRUMP 482 00:21:14,360 --> 00:21:15,400 WHICH RECEIVED A 25 PERCENT 483 00:21:15,400 --> 00:21:18,280 CUT WHICH WE PAID NO ATTENTION 484 00:21:18,280 --> 00:21:21,320 BECAUSE WE KNEW CONGRESS WAS 485 00:21:21,320 --> 00:21:23,040 GOING TO RESCUE IT. 486 00:21:23,040 --> 00:21:27,360 THIS IS NOT TO BE EXPECTED 487 00:21:27,360 --> 00:21:29,160 THIS TIME AROUND, MAKING A 488 00:21:29,160 --> 00:21:33,200 25 PERCENT CUT IN THE BUDGET 489 00:21:33,200 --> 00:21:33,680 AT NIAID. 490 00:21:33,680 --> 00:21:36,640 THIS IS APPROPRIATIONS AT THIS 491 00:21:36,640 --> 00:21:41,520 POINT, THE HOUSE APPROPRIATION 492 00:21:41,520 --> 00:21:42,760 COMMITTEE RECOMMENDED A 493 00:21:42,760 --> 00:21:45,520 22 PERCENT CUT IN THE BUDGET 494 00:21:45,520 --> 00:21:47,600 OF NIAID AND YOU CAN IMAGINE 495 00:21:47,600 --> 00:21:49,640 THERE IS A LITTLE RETRIBUTION 496 00:21:49,640 --> 00:21:51,320 IN THAT. 497 00:21:51,320 --> 00:21:55,720 THE SENATE HAS RECOMMENDED A 498 00:21:55,720 --> 00:21:56,560 0 PERCENT INCREASE IN THE 499 00:21:56,560 --> 00:21:58,760 BUDGET AND OF COURSE THE BEST 500 00:21:58,760 --> 00:22:01,200 WE CAN COME OUT WITH IN THE 501 00:22:01,200 --> 00:22:05,600 FALL WILL BE A CONTINUING 502 00:22:05,600 --> 00:22:08,120 RESOLUTION, NOT THAT A BUDGET 503 00:22:08,120 --> 00:22:14,040 WILL BE PASSED, WE COULD GO 504 00:22:14,040 --> 00:22:16,280 INTO A SHUTDOWN AND NOT TO GET 505 00:22:16,280 --> 00:22:19,440 POLITICAL HERE BUT WE HAVE NO 506 00:22:19,440 --> 00:22:21,080 IDEA WHERE THINGS WILL END UP 507 00:22:21,080 --> 00:22:23,200 BUT IT DOES NOT LOOK GOOD FOR 508 00:22:23,200 --> 00:22:24,800 AN INCREASE AND THERE COULD BE 509 00:22:24,800 --> 00:22:27,320 A DECREASE FOR FUNDING AT 510 00:22:27,320 --> 00:22:28,640 NIAID IN THE COMING YEAR. 511 00:22:28,640 --> 00:22:33,520 WITH THAT IN MIND, OUR INTERIM 512 00:22:33,520 --> 00:22:39,520 MANAGEMENT PLAN INVOLVES A 8TH 513 00:22:39,520 --> 00:22:42,920 PERT TILE -- PERCENTTILE PAY 514 00:22:42,920 --> 00:22:46,520 LINE WITH 12 PERCENT FOR 515 00:22:46,520 --> 00:22:47,720 INVESTIGATORS AND I THINK THAT 516 00:22:47,720 --> 00:22:49,720 IS AS BAD AS WE HAVE STARTED 517 00:22:49,720 --> 00:22:51,440 ANY YEAR. 518 00:22:51,440 --> 00:22:53,320 WITH THIS LINE, WE SHOULD NOT 519 00:22:53,320 --> 00:22:58,680 EXPECT TO HAVE CHANGES OR 520 00:22:58,680 --> 00:23:00,440 DOWNWARD PROJECTIONS BUT NIH 521 00:23:00,440 --> 00:23:02,240 IS DISCUSSING A ACROSS THE 522 00:23:02,240 --> 00:23:04,920 BOARD 10 PERCENT CUT IN 523 00:23:04,920 --> 00:23:07,280 NONCOMPETING AWARDS THIS YEAR. 524 00:23:07,280 --> 00:23:11,520 WE WILL DIG HEAVILY INTO OUR 525 00:23:11,520 --> 00:23:12,240 COMPETING RESEARCH INITIATIVES 526 00:23:12,240 --> 00:23:13,800 IN ORDER TO DO THE BEST THAT 527 00:23:13,800 --> 00:23:17,920 WE CAN TO PROTECT OUR PAY LINE 528 00:23:17,920 --> 00:23:19,400 BUT THE SUCCESS RATES 529 00:23:19,400 --> 00:23:20,920 ANTICIPATED THERE ARE 530 00:23:20,920 --> 00:23:23,040 DISCOURAGINGLY LOW, EVEN FROM 531 00:23:23,040 --> 00:23:25,160 THE TIME WHEN THEY HAVE BEEN 532 00:23:25,160 --> 00:23:26,000 DISCOURAGINGLY LOW FOR A 533 00:23:26,000 --> 00:23:26,560 WHILE. 534 00:23:26,560 --> 00:23:29,880 NOW I WILL RECAP SOME OF THE 535 00:23:29,880 --> 00:23:31,760 EXTRA FUNDING WE GOT FOR COVID 536 00:23:31,760 --> 00:23:33,160 OVER THE PAST TWO YEARS. 537 00:23:33,160 --> 00:23:36,080 WE MENTIONED IT BEFORE. 538 00:23:36,080 --> 00:23:40,000 WE GOT AN APPROPRIATION OF 539 00:23:40,000 --> 00:23:40,440 $1.5 BILLION. 540 00:23:40,440 --> 00:23:42,280 A LARGE PORTION OF THAT WAS AT 541 00:23:42,280 --> 00:23:44,360 RISK WHEN THEY ANNOUNCED ANY 542 00:23:44,360 --> 00:23:45,640 PENDING MONEY THAT HAD NOT 543 00:23:45,640 --> 00:23:47,760 GONE OUT THE DOOR WOULD BE 544 00:23:47,760 --> 00:23:49,360 CONFISCATED OR TAKEN BACK AS 545 00:23:49,360 --> 00:23:53,920 OF JUNE 1ST AS PART OF THE 546 00:23:53,920 --> 00:23:54,640 BUDGET CEILING NEGOTIATIONS. 547 00:23:54,640 --> 00:23:57,920 IN THE END, WE ONLY LOST 548 00:23:57,920 --> 00:23:59,480 $3 MILLION BECAUSE OF THE 549 00:23:59,480 --> 00:24:01,360 EXTRAORDINARY HARD WORK OF OUR 550 00:24:01,360 --> 00:24:02,080 GRANTS MANAGED PROGRAM. 551 00:24:02,080 --> 00:24:05,040 AND ON TOP OF THAT 1.5, WE 552 00:24:05,040 --> 00:24:08,320 ALSO RECEIVED MORE THAN 553 00:24:08,320 --> 00:24:10,480 $3 BILLION THROUGH WHAT WAS 554 00:24:10,480 --> 00:24:13,800 MOST RECENTLY CALLED H-CORE 555 00:24:13,800 --> 00:24:14,800 BUT WAS ORIGINALLY OPERATIONS 556 00:24:14,800 --> 00:24:16,360 WORK AND THIS IS MONEY THAT 557 00:24:16,360 --> 00:24:18,560 FLOWED TO US FROM THE KEPT 558 00:24:18,560 --> 00:24:19,960 DEPARTMENT OF HEALTH AND HUMAN 559 00:24:19,960 --> 00:24:21,720 SERVICES SO YOU COULD SEE WE 560 00:24:21,720 --> 00:24:24,120 HAD A VERY LARGE INFUSION OF 561 00:24:24,120 --> 00:24:26,680 COVID FUNDING DURING THIS 562 00:24:26,680 --> 00:24:27,240 TIME. 563 00:24:27,240 --> 00:24:28,960 LEGISLATIVE UPDATE, THIS IS A 564 00:24:28,960 --> 00:24:30,200 VERY SHORT LIST COME FIRED 565 00:24:30,200 --> 00:24:31,840 WHAT YOU HAVE SEEN IN THE PAST 566 00:24:31,840 --> 00:24:36,280 AND YOU NOTICE MY NAME IS ON 567 00:24:36,280 --> 00:24:38,040 ON THERE -- NOT ON THERE AS 568 00:24:38,040 --> 00:24:39,400 WELL. 569 00:24:39,400 --> 00:24:42,440 I HAVE NOT HAD ANY INTERACTION 570 00:24:42,440 --> 00:24:44,320 WITH CONGRESS AND THE 571 00:24:44,320 --> 00:24:45,480 LEGISLATIVE OFFICE HAS WORKED 572 00:24:45,480 --> 00:24:47,120 HARD TO KEEP IT THAT WAY. 573 00:24:47,120 --> 00:24:48,560 THANK YOU EMILY AND JOE FOR 574 00:24:48,560 --> 00:24:50,800 THE WORK THAT YOU DID. 575 00:24:50,800 --> 00:24:55,520 AND THIS GROUP HAS BEEN 576 00:24:55,520 --> 00:24:57,200 HANDLING A BARAGE OF REQUESTS 577 00:24:57,200 --> 00:24:58,280 FOR INFORMATION FROM CONGRESS 578 00:24:58,280 --> 00:24:59,680 THAT HAS REALLY BURDENED THEM 579 00:24:59,680 --> 00:25:01,880 IN THE PAST THREE TO FOUR 580 00:25:01,880 --> 00:25:02,680 MONTHS. 581 00:25:02,680 --> 00:25:06,720 NOW SOME DISEASE UPDATES IN 582 00:25:06,720 --> 00:25:08,080 SECOND AREAS, FIRST COVID-19, 583 00:25:08,080 --> 00:25:09,640 I THINK YOU ARE AWARE THAT 584 00:25:09,640 --> 00:25:17,720 THERE IS A SURGE OF 585 00:25:17,720 --> 00:25:18,520 HOSPITALIZATIONS. 586 00:25:18,520 --> 00:25:23,480 THERE IS NOT A SCORES 587 00:25:23,480 --> 00:25:24,960 RESPONDING -- CORRESPONDING 588 00:25:24,960 --> 00:25:28,760 SURGE IN DEATHS FROM COVID. 589 00:25:28,760 --> 00:25:29,440 IF YOU GO BACK AND LOOK AT THE 590 00:25:29,440 --> 00:25:35,240 WASTEWATER, YOU CAN SEE THAT 591 00:25:35,240 --> 00:25:39,160 IT WAS HIGH BEFORE THE SURGE 592 00:25:39,160 --> 00:25:40,440 SO THERE MAY HAVE BEEN PEOPLE 593 00:25:40,440 --> 00:25:50,520 WHO WERE SICK AND DIDN'T KNOW 594 00:25:50,520 --> 00:25:51,160 IT. 595 00:25:51,160 --> 00:25:52,240 WITHIN THE LAST FEW WEEKS, 596 00:25:52,240 --> 00:25:55,760 THERE HAVE BEEN A NUMBER OF 597 00:25:55,760 --> 00:25:57,600 PEOPLE WHO GOT COVID SO IT IS 598 00:25:57,600 --> 00:25:59,360 OUT THERE. 599 00:25:59,360 --> 00:26:01,080 THE FDA ADVISORY COMMITTEE 600 00:26:01,080 --> 00:26:02,760 BACK IN JUNE UNANIMOUSLY 601 00:26:02,760 --> 00:26:05,000 RECOMMENDED THAT DURING THE 602 00:26:05,000 --> 00:26:10,120 FALL, THERE SHOULD BE 603 00:26:10,120 --> 00:26:13,240 IMMUNIZATION WITH XBB LINEAGE 604 00:26:13,240 --> 00:26:17,680 OF OMICRON, SO THAT WAS THEIR 605 00:26:17,680 --> 00:26:18,120 RECOMMENDATION. 606 00:26:18,120 --> 00:26:19,560 TOMORROW, ASA, ADVISORY 607 00:26:19,560 --> 00:26:20,480 COMMITTEE ON IMMUNIZATION 608 00:26:20,480 --> 00:26:23,680 PRACTICES WHICH IS THE CDC 609 00:26:23,680 --> 00:26:24,520 ADVISORY COMMITTEE, TOMORROW 610 00:26:24,520 --> 00:26:25,520 THAT GROUP WILL MEET AND I 611 00:26:25,520 --> 00:26:27,960 SUSPECT THEY WILL COME UP WITH 612 00:26:27,960 --> 00:26:28,760 THE SAME RECOMMENDATION BUT 613 00:26:28,760 --> 00:26:30,040 WHETHER IT WILL BE FOR 614 00:26:30,040 --> 00:26:32,360 EVERYBODY OR OLD PEOPLE, I CAN 615 00:26:32,360 --> 00:26:40,920 TELL YOU MY LAST BOOSTER WAS A 616 00:26:40,920 --> 00:26:42,840 YEAR AGO AND I AM TOTALLY 617 00:26:42,840 --> 00:26:45,480 HAPPY TO GET ANOTHER COVID 618 00:26:45,480 --> 00:26:47,160 SHOT. 619 00:26:47,160 --> 00:26:51,120 I HAVE HAD MAYBE THREE 620 00:26:51,120 --> 00:26:54,240 MODERNA, TWO PFIZER ALONG WITH 621 00:26:54,240 --> 00:26:55,040 THE VACCINE ROUND. 622 00:26:55,040 --> 00:26:57,800 SO THE WHITE HOUSE HAS 623 00:26:57,800 --> 00:26:59,280 LAUNCHED SOMETHING CALLED 624 00:26:59,280 --> 00:27:04,800 PROJECT NEXT GEN, THE PARTING 625 00:27:04,800 --> 00:27:06,440 PROGRAM INITIATIVE AND IN 626 00:27:06,440 --> 00:27:09,000 PARTNERSHIP WITH US BUT WE'RE 627 00:27:09,000 --> 00:27:10,200 A RELATIVELY SMALL COMPONENT 628 00:27:10,200 --> 00:27:11,000 TO IT. 629 00:27:11,000 --> 00:27:13,600 ORIGINALLY WE WERE ALLOCATED 630 00:27:13,600 --> 00:27:16,640 $3 BILLION OUT OF A $5 BILLION 631 00:27:16,640 --> 00:27:17,040 SET-ASIDE. 632 00:27:17,040 --> 00:27:19,040 WE HAVE ADDED SOME OF OUR OWN 633 00:27:19,040 --> 00:27:22,960 FUNDING TO GET CLOSE TO 634 00:27:22,960 --> 00:27:24,920 $5 MILLION FOR VACCINE TRIALS 635 00:27:24,920 --> 00:27:30,360 AS A PROPOSAL FOR IMMUNITY OR 636 00:27:30,360 --> 00:27:31,080 BROADER IMMUNIZATION TUBE TO 637 00:27:31,080 --> 00:27:35,080 THE VIRUS SO WE ARE PART OF 638 00:27:35,080 --> 00:27:35,360 THIS. 639 00:27:35,360 --> 00:27:38,800 HIV AIDS, THIS IS THE 20TH 640 00:27:38,800 --> 00:27:41,600 ANNIVERSARY OF PEPTAR, ONE OF 641 00:27:41,600 --> 00:27:43,480 THE MOST SUCCESSFUL HEALTH 642 00:27:43,480 --> 00:27:46,880 PROGRAMS OF ALL TIME, THE 643 00:27:46,880 --> 00:27:51,640 PEOPLE IN SUBSAHARA AFRICA 644 00:27:51,640 --> 00:27:52,320 RECEIVING TREATMENT, AROUND 645 00:27:52,320 --> 00:28:00,000 65 MILLION AND YET THE RENEWAL 646 00:28:00,000 --> 00:28:04,360 OF PETFAR IS IN SERIOUS 647 00:28:04,360 --> 00:28:07,000 TROUBLE UNDER CLAIMS IT 648 00:28:07,000 --> 00:28:08,160 CREATES ABORTION WHICH IT 649 00:28:08,160 --> 00:28:10,640 DOESN'T BUT JUST OVER THIS 650 00:28:10,640 --> 00:28:11,560 WEEKEND, THERE WAS WRITING 651 00:28:11,560 --> 00:28:12,680 ABOUT THE THREAT OF GLOBAL 652 00:28:12,680 --> 00:28:16,760 HEALTH AS A RESULT OF THE 653 00:28:16,760 --> 00:28:19,560 UNCERTAINTIES THAT WE WILL 654 00:28:19,560 --> 00:28:21,880 ACTUALLY BALLOON THE PETFAR 655 00:28:21,880 --> 00:28:22,440 PROGRAM. 656 00:28:22,440 --> 00:28:24,680 ANOTHER ITEM IN THE HIV AREA 657 00:28:24,680 --> 00:28:26,840 IS THE RECOGNITION BY THE 658 00:28:26,840 --> 00:28:28,520 PREVENTIVE SERVICES TASK FORCE 659 00:28:28,520 --> 00:28:30,520 OF THE UNITED STATES THAT THEY 660 00:28:30,520 --> 00:28:33,880 WOULD GIVE A GRADE A 661 00:28:33,880 --> 00:28:35,520 RECOMMENDATION TO GIVING PREP 662 00:28:35,520 --> 00:28:37,120 TO HIGH RISK INDIVIDUALS. 663 00:28:37,120 --> 00:28:40,840 THAT SHOULD MEAN THAT THAT 664 00:28:40,840 --> 00:28:42,720 TREATMENT, THAT PREP WOULD BE 665 00:28:42,720 --> 00:28:43,280 COVERED BY INSURANCE. 666 00:28:43,280 --> 00:28:45,360 I THINK THIS IS A MAJOR 667 00:28:45,360 --> 00:28:46,800 ACHIEVEMENT AND THE EVIDENCE 668 00:28:46,800 --> 00:28:49,440 TO SUPPORT THIS GRADE A 669 00:28:49,440 --> 00:28:50,200 RECOMMENDATION ALMOST ENTIRELY 670 00:28:50,200 --> 00:28:52,800 COMES FROM THE WORK OF NIAI 671 00:28:52,800 --> 00:28:53,280 ID. 672 00:28:53,280 --> 00:28:55,680 THERE HAS BEEN A SLOW DECREASE 673 00:28:55,680 --> 00:28:58,120 IN THE INCIDENTS IN THIS 674 00:28:58,120 --> 00:28:58,640 COUNTRY. 675 00:28:58,640 --> 00:28:59,840 TO SOME EXTENT I SUPPOSE THAT 676 00:28:59,840 --> 00:29:03,280 MAY BE THE RESULT OF THE END 677 00:29:03,280 --> 00:29:06,080 OF THE HIV EPIDEMIC INITIATIVE 678 00:29:06,080 --> 00:29:07,880 THAT DATES BACK TO 2019. 679 00:29:07,880 --> 00:29:09,680 THE GOAL FOR THAT OVERALL 680 00:29:09,680 --> 00:29:13,280 PROGRAM WHICH IS NOW FUNNED 681 00:29:13,280 --> 00:29:16,240 AND MANDATED -- FUNDED AND 682 00:29:16,240 --> 00:29:21,480 MANDATED BY CONGRESS IS NOW A 683 00:29:21,480 --> 00:29:22,600 30 YEAR PROGRAM TO 2030. 684 00:29:22,600 --> 00:29:26,400 IT IS PARTICIPATION SCIENCE 685 00:29:26,400 --> 00:29:30,200 AND ROUGHLY $85 MILLION HAS 686 00:29:30,200 --> 00:29:32,120 BEEN ALLOCATED TO THIS EFFORT 687 00:29:32,120 --> 00:29:34,040 AND MORE THAN 200-PLUS 688 00:29:34,040 --> 00:29:36,040 SUPPLEMENTS HAVE BEEN AWARDED. 689 00:29:36,040 --> 00:29:38,480 WE TOLD YOU BEFORE ABOUT THE 690 00:29:38,480 --> 00:29:40,200 REPRIEVE STUDY AND ITS RESULTS 691 00:29:40,200 --> 00:29:42,600 BUT THE STUDY RESULTS WERE 692 00:29:42,600 --> 00:29:45,440 JUST PUBLISHED BY THE NEW 693 00:29:45,440 --> 00:29:47,840 ENGLAND JOURNAL OF MEDICINE IN 694 00:29:47,840 --> 00:29:53,160 LATE AUGUST AND IT IS AN 695 00:29:53,160 --> 00:29:55,920 ASTOUNDING OUTCOME IN ADVERSE 696 00:29:55,920 --> 00:30:00,440 CARDIAC EVENTS FOR PEOPLE WHO 697 00:30:00,440 --> 00:30:02,240 HAVE BEEN IN TREATMENT AND 698 00:30:02,240 --> 00:30:08,960 THIS IS ANOTHER MAJOR 699 00:30:08,960 --> 00:30:10,880 ACCOMPLISHMENT OF TREATMENT OF 700 00:30:10,880 --> 00:30:11,200 AIDS. 701 00:30:11,200 --> 00:30:15,480 AND THEN ANOTHER PAPER 702 00:30:15,480 --> 00:30:16,480 PUBLISHED TALKING ABOUT THE 703 00:30:16,480 --> 00:30:21,360 BODIES WITH A THIRD ARM THAT 704 00:30:21,360 --> 00:30:24,600 IS A NEUTRALIZING ANTIBODY, TO 705 00:30:24,600 --> 00:30:25,960 STIMULATE LATENTLY EXPRESSING 706 00:30:25,960 --> 00:30:30,840 CELLS SO IF THEY DO EGGS 707 00:30:30,840 --> 00:30:35,640 SUPPRESS THE -- EXPRESS HIV 708 00:30:35,640 --> 00:30:37,760 VIRUS, THEY NEUTRALIZE THE 709 00:30:37,760 --> 00:30:40,240 ANTIBODY ARM SO THIS PROOF OF 710 00:30:40,240 --> 00:30:41,280 CONCEPT WAS ENCOURAGING. 711 00:30:41,280 --> 00:30:43,680 NOW WE'RE GOING TO TALK A 712 00:30:43,680 --> 00:30:45,720 LITTLE BIT ABOUT MEDICAL 713 00:30:45,720 --> 00:30:47,920 COUNTER MEASURES VERY CLOSE TO 714 00:30:47,920 --> 00:30:48,720 THE FINISH LINE. 715 00:30:48,720 --> 00:30:51,120 OFTEN WHEN WE TALK TO YOU 716 00:30:51,120 --> 00:30:53,720 ABOUT VACCINES AND OTHER 717 00:30:53,720 --> 00:30:55,280 COUNTER MEASURES, WE TALK 718 00:30:55,280 --> 00:30:57,120 ABOUT RESULTS THAT HAVE COME 719 00:30:57,120 --> 00:30:58,720 WITH MONKEYS OR FERRETS. 720 00:30:58,720 --> 00:31:01,400 EVERYTHING I AM ABOUT TO TELL 721 00:31:01,400 --> 00:31:06,040 YOU IS ABOUT CLINICAL RESULTS 722 00:31:06,040 --> 00:31:09,440 THAT HAVE COME FROM A GROUP OF 723 00:31:09,440 --> 00:31:09,920 VACCINES. 724 00:31:09,920 --> 00:31:13,760 FIRST IN 2013, PEOPLE QUONG 725 00:31:13,760 --> 00:31:16,640 TEAMED UP WITH BARNEY GREEN 726 00:31:16,640 --> 00:31:18,680 AND JASON MCLELLAN TO 727 00:31:18,680 --> 00:31:20,080 DETERMINE THE STRUCTURE OF THE 728 00:31:20,080 --> 00:31:22,600 F PROTEIN IN ITS PREFUSION 729 00:31:22,600 --> 00:31:24,720 STATE THAT SITS ON THE SURFACE 730 00:31:24,720 --> 00:31:27,720 OF THE HSV. 731 00:31:27,720 --> 00:31:28,520 THEY-- RSV. 732 00:31:28,520 --> 00:31:30,360 THEY ALSO LEARNED THIS 733 00:31:30,360 --> 00:31:32,720 UNSTABLE MOLECULE NEEDS TO BE 734 00:31:32,720 --> 00:31:35,200 STABILIZED IF IT IS GOING TO 735 00:31:35,200 --> 00:31:38,200 BE A GOOD IMMUGEN. 736 00:31:38,200 --> 00:31:41,360 THE RESULTS WERE PUBLIC BEFORE 737 00:31:41,360 --> 00:31:45,080 I HAD -- PUBLISHED AFTER 20 738 00:31:45,080 --> 00:31:51,000 YEARS OF A STUDY AND NOW WE 739 00:31:51,000 --> 00:32:00,200 HAVE FDA APPROVAL FOR SEVERAL 740 00:32:00,200 --> 00:32:02,080 PRODUCTS, THE MONOCLONAL 741 00:32:02,080 --> 00:32:04,160 ANTIBODY AGAINST RSV RECEIVED 742 00:32:04,160 --> 00:32:11,000 APPROVAL FROM AS HAVE A 743 00:32:11,000 --> 00:32:17,360 SENECA -- ASTRA ZENECA AND A 744 00:32:17,360 --> 00:32:18,840 THIRD VACCINE FOR PREGNANT 745 00:32:18,840 --> 00:32:22,480 WOMEN TO EXTEND THE IMMUNITY 746 00:32:22,480 --> 00:32:23,760 TO THE UNBORN CHILD IS THIS 747 00:32:23,760 --> 00:32:28,640 HAS BEEN AN AMAZING YEAR FOR 748 00:32:28,640 --> 00:32:30,120 THE RESEARCH CENTER. 749 00:32:30,120 --> 00:32:34,880 THE OTHER APPROACH TO RSV 750 00:32:34,880 --> 00:32:38,160 VACCINOLOGY COMES OUT OF THE 751 00:32:38,160 --> 00:32:40,240 INTRAMURAL PROGRAM WITH THE 752 00:32:40,240 --> 00:32:42,200 LIVE ATTEN UNITED VACCINE, 753 00:32:42,200 --> 00:32:44,560 GOING ON FOR DECADES AND NOW 754 00:32:44,560 --> 00:32:50,280 THE WORK OF ZULA WITH A LIVE 755 00:32:50,280 --> 00:32:53,720 ATTEN UNITED VACCINE FOR 756 00:32:53,720 --> 00:32:56,880 YOUNGER CHILDREN AND THIS HAS 757 00:32:56,880 --> 00:32:59,400 BEEN PROMISING AS WELL WITH 758 00:32:59,400 --> 00:33:00,680 RESULTS. 759 00:33:00,680 --> 00:33:02,160 THERE WAS FDA APPROVAL OVER 760 00:33:02,160 --> 00:33:07,960 THE LAST FOUR MONTHS FOR A 761 00:33:07,960 --> 00:33:09,960 TWO-DAYS PROPHYLAXIS FOR A 762 00:33:09,960 --> 00:33:11,160 ANTHRAX VACCINE. 763 00:33:11,160 --> 00:33:21,720 THERE IS -- THIS IS THE STEVE 764 00:33:22,280 --> 00:33:24,400 WHITEHEAD PETROVAILANT DENGKE 765 00:33:24,400 --> 00:33:25,760 VACCINE HE HAS BEEN WORKING ON 766 00:33:25,760 --> 00:33:27,840 SINCE I GOT HERE AND YOU CAN 767 00:33:27,840 --> 00:33:30,440 SEE THE PHASE 3 TRIAL IN 768 00:33:30,440 --> 00:33:34,000 BRAZIL WITH 80 TO 90 P-Z 769 00:33:34,000 --> 00:33:35,720 EFFICACY. 770 00:33:35,720 --> 00:33:37,680 TRIALS GOING ON IN AFRICA AND 771 00:33:37,680 --> 00:33:39,840 IT IS VERY LIKELY THIS WILL 772 00:33:39,840 --> 00:33:43,960 END UP BEING THE VACCINE IN 773 00:33:43,960 --> 00:33:44,640 THE FUTURE WORLDWIDE. 774 00:33:44,640 --> 00:33:46,480 WE HAVE BEEN TALKING ABOUT 775 00:33:46,480 --> 00:33:48,000 FLU VACCINES FOR A LONG TIME. 776 00:33:48,000 --> 00:33:53,200 NOW WE ARE IN PHASE 1 TRIALS 777 00:33:53,200 --> 00:33:59,720 OF THE VACCINE AT RESEARCH 778 00:33:59,720 --> 00:34:00,640 CENTERS INCLUDING THE SIX 779 00:34:00,640 --> 00:34:04,840 INFLUENZA STRAINS AND THAT IS 780 00:34:04,840 --> 00:34:08,040 A OPEN LABEL 1 STUDY. 781 00:34:08,040 --> 00:34:16,960 THE INTRAMURAL STUDY, DIR, 782 00:34:16,960 --> 00:34:18,680 JEFF KOHENBERGER AND EMILY ARE 783 00:34:18,680 --> 00:34:29,000 WORKING ON THEIR VACCINE WHICH 784 00:34:29,000 --> 00:34:30,720 CONTAINS IMMUONOGENS COMBINED 785 00:34:30,720 --> 00:34:33,560 AND THEY ARE NOW IN PHASE 1 786 00:34:33,560 --> 00:34:36,240 WORKING ON THAT COHORT WITH 787 00:34:36,240 --> 00:34:36,680 PATIENTS. 788 00:34:36,680 --> 00:34:40,880 THE VACCINE BASED ON M72 789 00:34:40,880 --> 00:34:42,320 RECOMBINANT FUSION PROTEIN 790 00:34:42,320 --> 00:34:44,520 WHICH WE WERE INVOLVED IN THE 791 00:34:44,520 --> 00:34:46,080 EARLY WORK GETTING DEVELOPED 792 00:34:46,080 --> 00:34:48,680 BUT THIS WILL BE TAKEN TO A 793 00:34:48,680 --> 00:34:52,760 PHASE 3 STUDY BY THE BILL AND 794 00:34:52,760 --> 00:34:53,560 MELINDA GATES FOUNDATION. 795 00:34:53,560 --> 00:34:56,800 THERE IS A CHICKEN PARTICLE 796 00:34:56,800 --> 00:34:58,800 THAT CAME DIRECTLY OUT OF THE 797 00:34:58,800 --> 00:35:03,040 VACCINE RESEARCH CENTER WHICH 798 00:35:03,040 --> 00:35:05,440 HAS SHOWN TREMENDOUS EFFICACY 799 00:35:05,440 --> 00:35:06,520 IN CLINICAL TRIALS WITH PLANS 800 00:35:06,520 --> 00:35:09,680 TO TAKE IT TO THE FDA EARLY 801 00:35:09,680 --> 00:35:13,280 NEXT YEAR FOR REGULATORY 802 00:35:13,280 --> 00:35:13,680 APPROVAL. 803 00:35:13,680 --> 00:35:18,240 THE DRC ALSO HAS A SUDAN EBOLA 804 00:35:18,240 --> 00:35:21,360 VIRUS, THE OTHER APPROVED 805 00:35:21,360 --> 00:35:23,760 EBOLA VACCINES DO NOT 806 00:35:23,760 --> 00:35:26,280 CROSS-REACT ON THE SUDAN 807 00:35:26,280 --> 00:35:28,160 SUB-TYPE SO THIS IS ANOTHER 808 00:35:28,160 --> 00:35:29,920 HELP FORWARD FOR THE VACCINE 809 00:35:29,920 --> 00:35:31,600 RESEARCH CENTER. 810 00:35:31,600 --> 00:35:32,680 AND FINALLY I JUST WANT TO 811 00:35:32,680 --> 00:35:35,000 REMIND YOU ABOUT THE SAFETY 812 00:35:35,000 --> 00:35:39,960 AND EFFICACY OF THE MONOCLONAL 813 00:35:39,960 --> 00:35:45,680 ANDY BODY FOR MALARIA WHICH 814 00:35:45,680 --> 00:35:47,040 SHOWS WILL -- 88 PERCENT 815 00:35:47,040 --> 00:35:51,520 EFFICACY WITH A SINGLE SHOT IN 816 00:35:51,520 --> 00:35:52,040 THE REGION. 817 00:35:52,040 --> 00:35:54,240 SO ALL OF THIS MEANS THESE 818 00:35:54,240 --> 00:35:56,320 PRODUCTS ARE REALLY ON THE 819 00:35:56,320 --> 00:35:57,440 ROAD TOWARDS REGULATORY 820 00:35:57,440 --> 00:35:57,800 APPROVAL. 821 00:35:57,800 --> 00:36:01,760 THIS IS THE YEAR FOR THE RSV, 822 00:36:01,760 --> 00:36:04,040 RACING TO THE FINISH LINE. 823 00:36:04,040 --> 00:36:06,640 THE COVID VACCINES WERE 824 00:36:06,640 --> 00:36:08,840 ALREADY OVER THERE BUT I HAVE 825 00:36:08,840 --> 00:36:19,400 MENTIONED TO YOU, THE DENGKE, 826 00:36:19,400 --> 00:36:21,600 MALARIA, CHICKEN VARIANT ARE 827 00:36:21,600 --> 00:36:24,040 REALLY RACING TOWARDS FDA 828 00:36:24,040 --> 00:36:25,520 APPROVAL SO IT IS A 829 00:36:25,520 --> 00:36:26,920 SPECTACULAR TIME. 830 00:36:26,920 --> 00:36:28,280 THIS VACCINE HUFFING AND 831 00:36:28,280 --> 00:36:29,680 PUFFING IN THE BACKGROUND 832 00:36:29,680 --> 00:36:31,200 THERE BUT THE FACT OF THE 833 00:36:31,200 --> 00:36:35,200 MATTER IS THE SUCCESS OF THE 834 00:36:35,200 --> 00:36:36,560 RSV PROGRAM DEPENDED ENTIRELY 835 00:36:36,560 --> 00:36:40,160 ON THE WORK PETER QUONG DID TO 836 00:36:40,160 --> 00:36:42,440 UNDERSTAND THE STRUCTURE OF 837 00:36:42,440 --> 00:36:46,240 STABILIZATION OF HIV GLYCO 838 00:36:46,240 --> 00:36:50,600 PROTEIN SO IT IS A DIRECT 839 00:36:50,600 --> 00:36:53,800 PRECURSOR SO THE EFFECT OF THE 840 00:36:53,800 --> 00:36:56,000 RSV VACCINE. 841 00:36:56,000 --> 00:36:59,760 SIMILARLY, IT IS A DIRECT 842 00:36:59,760 --> 00:37:06,520 PRECURSOR TO THE COVID VACCINE 843 00:37:06,520 --> 00:37:10,040 WHICH BARNEY REALIZED HOW TO 844 00:37:10,040 --> 00:37:11,880 STABILIZE AND MADE SUCCESSFUL 845 00:37:11,880 --> 00:37:14,200 VACCINES FOR COVID IN LESS 846 00:37:14,200 --> 00:37:15,680 THAN A YEAR. 847 00:37:15,680 --> 00:37:17,080 VERY BRIEFLY A COUPLE OF 848 00:37:17,080 --> 00:37:19,440 UPDATES TO MENTION TO YOU, 849 00:37:19,440 --> 00:37:20,400 THIS HIGHLIGHTS THE FACT THAT 850 00:37:20,400 --> 00:37:23,160 THE FOOD AND DRUG 851 00:37:23,160 --> 00:37:27,160 ADMINISTRATION HAS APPROVED A 852 00:37:27,160 --> 00:37:36,760 TREATMENT FOR CHAPEL DISEASE. 853 00:37:36,760 --> 00:37:42,400 THIS HAS BEEN IDENTIFIED IN 854 00:37:42,400 --> 00:37:45,040 THE CLINICAL CENTER THAT MIKE 855 00:37:45,040 --> 00:37:46,720 LEONARDO WAS ABLE TO DETERMINE 856 00:37:46,720 --> 00:37:51,080 THE BASIS FOR THIS DISEASE WAS 857 00:37:51,080 --> 00:37:53,320 A GENETIC SUFFICIENCY IN CD55 858 00:37:53,320 --> 00:37:56,000 WHICH IF YOU ARE OLD ENOUGH, 859 00:37:56,000 --> 00:37:57,760 WE USED TO CALL DECELERATING 860 00:37:57,760 --> 00:37:58,080 FACTORS. 861 00:37:58,080 --> 00:38:00,800 THE BOTTOM LINE IS WITHOUT 862 00:38:00,800 --> 00:38:02,520 THIS COMBINATION YOU HAD RUN 863 00:38:02,520 --> 00:38:04,120 AWAY ACTIVATION IN THIS 864 00:38:04,120 --> 00:38:05,720 SYNDROME AND THE RESULT OF 865 00:38:05,720 --> 00:38:10,000 THAT IS A PROTEIN END THEY 866 00:38:10,000 --> 00:38:11,240 AREOPATHY OF MAJOR 867 00:38:11,240 --> 00:38:11,800 PROPORTIONS. 868 00:38:11,800 --> 00:38:14,200 SO THEY IDENTIFIED THE CAUSE 869 00:38:14,200 --> 00:38:17,840 OF THE DISEASE, ITS 870 00:38:17,840 --> 00:38:20,000 PATHOPHYSIOLOGY AND THEN MIKE 871 00:38:20,000 --> 00:38:28,440 WENT TO ABENERON ASKING TO USE 872 00:38:28,440 --> 00:38:29,480 A AD T5 ANTIBODY. 873 00:38:29,480 --> 00:38:34,560 THIS IS A CHILD WHO WAS IN HIS 874 00:38:34,560 --> 00:38:35,880 EARLY TEENS WHO WEIGHED 875 00:38:35,880 --> 00:38:36,400 28 POUNDS. 876 00:38:36,400 --> 00:38:41,200 THIS PROCEED TEEN LOSING END 877 00:38:41,200 --> 00:38:45,400 THEY AREOPATHY BASED WOULD 878 00:38:45,400 --> 00:38:50,040 STARVE PEOPLE TO DEATH AT AN 879 00:38:50,040 --> 00:38:52,440 EARLY AGE AND THIS TEEN LOOKED 880 00:38:52,440 --> 00:38:55,760 LIKE THIS AFTER TWO YEARS OF 881 00:38:55,760 --> 00:38:56,720 TREATMENT WITH THE ANTIBODY. 882 00:38:56,720 --> 00:38:59,240 SO IT IS RECOGNIZED EARLY IN 883 00:38:59,240 --> 00:39:02,480 THE PROGRAM, ITS 884 00:39:02,480 --> 00:39:03,600 PATHOPHYSIOLOGY IDENTIFIED IN 885 00:39:03,600 --> 00:39:04,680 OUR PROGRAMS, TREATMENT 886 00:39:04,680 --> 00:39:07,400 IDENTIFIED AND TAKEN TO FDA 887 00:39:07,400 --> 00:39:09,600 APPROVAL BY AN INVESTIGATOR IN 888 00:39:09,600 --> 00:39:10,200 THE INTRAMURAL PROGRAM. 889 00:39:10,200 --> 00:39:12,000 SO WE WANT TO REMIND EVERYBODY 890 00:39:12,000 --> 00:39:17,640 THAT WE ARE STILL ENTRUSTED IN 891 00:39:17,640 --> 00:39:21,800 LYME DISEASE. 892 00:39:21,800 --> 00:39:28,320 DEAMON HAS RECEIVED A -- 893 00:39:28,320 --> 00:39:30,200 [INDISCERNIBLE] 894 00:39:30,200 --> 00:39:33,920 SO WORKING WITH OUT OF MIND 895 00:39:33,920 --> 00:39:35,360 LYME DISEASE COMPLICATIONS. 896 00:39:35,360 --> 00:39:37,080 WE WANT TO HIGHLIGHT THOSE 897 00:39:37,080 --> 00:39:38,800 INDIVIDUALS WORKING IN THE 898 00:39:38,800 --> 00:39:47,360 PROGRAM WHO HAVE COMBINED 899 00:39:47,360 --> 00:39:48,000 SKIDS AND THIS PUBLICATION 900 00:39:48,000 --> 00:39:49,040 HIGHLIGHTED IF YOU SCREEN FOR 901 00:39:49,040 --> 00:39:56,760 THESE PATIENTS RATHER THAN 902 00:39:56,760 --> 00:39:57,400 DEPENDING ON FAMILY HISTORY, 903 00:39:57,400 --> 00:39:58,080 YOU GET EVEN BETTER SURVIVAL 904 00:39:58,080 --> 00:40:06,880 WITH BONE MARIO TRANSPLANT -- 905 00:40:06,880 --> 00:40:10,000 -- MARROW TRANSPLANT OF FIVE 906 00:40:10,000 --> 00:40:10,280 YEARS. 907 00:40:10,280 --> 00:40:16,280 [ ARE AUDIO CUTTING OUT ] 908 00:40:16,280 --> 00:40:22,080 BUT THE ANTIBODY CAUSES 909 00:40:22,080 --> 00:40:23,040 THROMBONE COMPLICATIONS AND 910 00:40:23,040 --> 00:40:23,640 HAS LIMITED USE. 911 00:40:23,640 --> 00:40:26,760 THIS IS A PAPER THAT DESCRIBES 912 00:40:26,760 --> 00:40:28,720 THE ANTIBODY THAT SEEMS NOT TO 913 00:40:28,720 --> 00:40:31,680 HAVE THOSE BODIES BUT HAS 914 00:40:31,680 --> 00:40:36,480 SPECTACULAR SUCCESS IN 915 00:40:36,480 --> 00:40:37,400 PROMOTING SURVIVAL. 916 00:40:37,400 --> 00:40:38,960 AND FINALLY WE WANT TO CALL 917 00:40:38,960 --> 00:40:41,680 ATTENTION TO FDA APPROVAL ALSO 918 00:40:41,680 --> 00:40:44,960 RECEIVED IN THIS CASE FOR TYPE 919 00:40:44,960 --> 00:40:46,520 1 DIABETES. 920 00:40:46,520 --> 00:40:57,120 THIS EFFORT BEGAN PRETTY MUCH 921 00:40:58,360 --> 00:41:00,360 ENTIRELY IN 2004 AND REQUIRED 922 00:41:00,360 --> 00:41:03,000 20 YEARS TO DEMONSTRATE TO THE 923 00:41:03,000 --> 00:41:08,720 FDA THAT WE KNEW HOW TO PURIFY 924 00:41:08,720 --> 00:41:10,160 ISLETS AND TREAT TYPE 1 925 00:41:10,160 --> 00:41:12,880 DIABETES SO THIS IS THE FDA 926 00:41:12,880 --> 00:41:15,160 ACKNOWLEDGEMENT THAT WE REALLY 927 00:41:15,160 --> 00:41:23,520 HAVE ACHIEVED THAT END GOAL. 928 00:41:23,520 --> 00:41:24,920 OKAY, THAT'S IT FOR OUR UPDATE 929 00:41:24,920 --> 00:41:27,680 AND I AM HAPPY TO TAKE ANY 930 00:41:27,680 --> 00:41:29,600 QUESTIONS FROM YOU. 931 00:41:29,600 --> 00:41:29,880 YES? 932 00:41:29,880 --> 00:41:36,960 >> HOW WILL YOU DECIDE ON THE 933 00:41:36,960 --> 00:41:40,160 R01 PAY LINES WITH THESE 934 00:41:40,160 --> 00:41:41,280 INCREASING POSSIBILITIES OF 935 00:41:41,280 --> 00:41:44,040 8 PERCENT FOR ESTABLISHED AND 936 00:41:44,040 --> 00:41:45,200 12 PERCENT FOR NEW? 937 00:41:45,200 --> 00:41:48,600 BUT THAT'S ONLY ON THE WORST 938 00:41:48,600 --> 00:41:52,520 CASE SCENARIO IN TERMS OF THE 939 00:41:52,520 --> 00:41:54,040 OCTOBER BUDGET OR PLANNING 940 00:41:54,040 --> 00:41:55,960 AHEAD OR EVEN IN THE 941 00:41:55,960 --> 00:41:57,400 POSSIBILITY OF A FLAT BUDGET, 942 00:41:57,400 --> 00:42:01,040 ONE THING THAT WOULD BE ON THE 943 00:42:01,040 --> 00:42:03,240 CUTTING BLOCK WOULD BE THOSE 944 00:42:03,240 --> 00:42:03,600 PAY LINES. 945 00:42:03,600 --> 00:42:05,560 >> USUALLY WE GO WITH OUR 946 00:42:05,560 --> 00:42:08,000 INTERIM PAY LINE TILL WE KNOW 947 00:42:08,000 --> 00:42:11,360 WHAT KIND OF BUDGET WE ARE 948 00:42:11,360 --> 00:42:11,800 GOING TO HAVE. 949 00:42:11,800 --> 00:42:13,080 THAT COULD BE DECEMBER, 950 00:42:13,080 --> 00:42:14,360 SOMETIMES LATER THAN THAT BUT 951 00:42:14,360 --> 00:42:18,000 ONCE WE KNOW WHAT OUR BUDGET 952 00:42:18,000 --> 00:42:21,080 SITUATION IS AND WITH THAT WE 953 00:42:21,080 --> 00:42:21,640 WOULD KNOW HOW MANY 954 00:42:21,640 --> 00:42:22,360 APPLICATIONS HAVE COME IN, WE 955 00:42:22,360 --> 00:42:27,280 COULD GO AHEAD AND RECALCULATE 956 00:42:27,280 --> 00:42:29,720 WHAT WILL BE CONTINUED TO US 957 00:42:29,720 --> 00:42:33,400 THROUGHOUT THE YEAR WHICH GOES 958 00:42:33,400 --> 00:42:35,920 RETROSPECTIVELY TO EVERYBODY 959 00:42:35,920 --> 00:42:37,960 WHO HAS ACHIEVED THAT 960 00:42:37,960 --> 00:42:39,560 PERCENTILE SO IT IS JUST A 961 00:42:39,560 --> 00:42:40,960 CALCULATION WE MAKE WHEN WE 962 00:42:40,960 --> 00:42:51,480 GET REAL NUMBERS WE CAN RELY 963 00:42:54,880 --> 00:43:01,400 ON. 964 00:43:01,400 --> 00:43:02,680 NO MORE QUESTIONS? 965 00:43:02,680 --> 00:43:07,040 THEN LET ME INTRODUCE NED 966 00:43:07,040 --> 00:43:09,680 PIERSON WHO WILL DISCUSS THE 967 00:43:09,680 --> 00:43:20,160 VACCINE RESEARCH CENTER. 968 00:43:31,160 --> 00:43:31,480 THANK YOU. 969 00:43:31,480 --> 00:43:34,120 >>> GOOD MORNING EVERYONE, I 970 00:43:34,120 --> 00:43:38,280 AM IN CHARGE OF THE CENTER AND 971 00:43:38,280 --> 00:43:45,160 PLEASED TO BE WITH YOU TO 972 00:43:45,160 --> 00:43:48,160 DISCUSS THE CENTER FROM JUST A 973 00:43:48,160 --> 00:43:48,520 YEAR AGO. 974 00:43:48,520 --> 00:43:53,720 SO IT IS A STRUCTURE THAT 975 00:43:53,720 --> 00:43:58,640 MAKES DISCOVERIES THAT SUPPORT 976 00:43:58,640 --> 00:44:01,200 VACCINES AND BIOLOGICS THAT 977 00:44:01,200 --> 00:44:02,440 AFFECT GLOBAL HEALTH 978 00:44:02,440 --> 00:44:03,000 IMPORTANCE. 979 00:44:03,000 --> 00:44:05,760 GOING TO VIRUSES, VIRUSES CAN 980 00:44:05,760 --> 00:44:07,040 BE CATEGORIZED AND GROUPED 981 00:44:07,040 --> 00:44:09,520 REALLY BY THE MACHINES THAT 982 00:44:09,520 --> 00:44:13,080 THEY USE TO CENTER CELLS SO 983 00:44:13,080 --> 00:44:16,760 THEY HAVE VIRTUALLY OCCLUDED 984 00:44:16,760 --> 00:44:19,720 PROTEINS THAT SHARE STRUCTURE 985 00:44:19,720 --> 00:44:24,720 AND FUNCTION AND CONSIDERING 986 00:44:24,720 --> 00:44:30,160 HOW A VIRUS INTRACELL WORKS, 987 00:44:30,160 --> 00:44:34,920 THESE ARE REALLY THE TARGET OF 988 00:44:34,920 --> 00:44:35,760 DISCOVERING THE ANTIBODIES SO 989 00:44:35,760 --> 00:44:36,920 THERE ARE A NUMBER OF 990 00:44:36,920 --> 00:44:39,200 STRATEGIES THAT MAY BE USEFUL 991 00:44:39,200 --> 00:44:40,800 ACROSS VIRUSES WITHIN ANY 992 00:44:40,800 --> 00:44:46,520 GIVEN GROUP. 993 00:44:46,520 --> 00:44:50,560 NOW THE VRC WAS FOUNDED IN 994 00:44:50,560 --> 00:44:54,400 1997 AND CERTAINLY BEFORE 995 00:44:54,400 --> 00:44:57,720 COVID, THE PROTEIN WAS THE 996 00:44:57,720 --> 00:44:58,760 MOST HIGHLY CHARACTERIZED OF 997 00:44:58,760 --> 00:45:01,000 WHAT IS CALLED THE CLASS 1 998 00:45:01,000 --> 00:45:04,120 FUSION PROGRAM AND THE INSIGHT 999 00:45:04,120 --> 00:45:05,840 INTO UNDERSTANDING HOW THE 1000 00:45:05,840 --> 00:45:07,960 FUSION 1 PROTEINS WORK UNDER 1001 00:45:07,960 --> 00:45:12,880 STRUCTURE HAS FUELED A LOT OF 1002 00:45:12,880 --> 00:45:19,560 THE PROGRESS OF B -- VRC HAS 1003 00:45:19,560 --> 00:45:30,080 DONE OVER THE YEARS, KEG 1004 00:45:31,120 --> 00:45:33,040 DECADES AND REALLY IS BOILS 1005 00:45:33,040 --> 00:45:34,280 DOWN TO SOLVING THE STRUCTURE 1006 00:45:34,280 --> 00:45:36,560 AND YOU USE THIS INFORMATION 1007 00:45:36,560 --> 00:45:38,000 TO CREATE PROBES THAT WILL 1008 00:45:38,000 --> 00:45:40,520 ALLOW YOU TO IDENTIFY HUMAN 1009 00:45:40,520 --> 00:45:42,480 ANTIBODIES WITH THE DESIRABLE 1010 00:45:42,480 --> 00:45:44,800 CHARACTERISTICS, YOU PULL OUT 1011 00:45:44,800 --> 00:45:47,160 THOSE ANTIBODIES AND THEN USE 1012 00:45:47,160 --> 00:45:51,920 THOSE ANTIBODIES AS A GUIDE TO 1013 00:45:51,920 --> 00:45:58,320 STABILIZE THESE PROTEINS TO 1014 00:45:58,320 --> 00:46:00,160 MAIM IMDEFENSE -- IMMUGENS. 1015 00:46:00,160 --> 00:46:06,480 SO I WANT TO EMPHASIZE THE 1016 00:46:06,480 --> 00:46:09,520 CONCEPT HAS IMPROVED 1017 00:46:09,520 --> 00:46:13,040 CONSIDERABLY BEYOND HIV TO 1018 00:46:13,040 --> 00:46:16,320 OTHER PROTEINS, SUCH AS RSV, 1019 00:46:16,320 --> 00:46:19,600 INFLUENZA AS WELL AS CONE IN A 1020 00:46:19,600 --> 00:46:20,080 VIRUSES. 1021 00:46:20,080 --> 00:46:22,920 IT HAS EXPANDED BEYOND THE 1022 00:46:22,920 --> 00:46:25,760 STUDY OF CLASS 1 FUSION 1023 00:46:25,760 --> 00:46:28,280 PROTEINS INCLUDING VIRUSES 1024 00:46:28,280 --> 00:46:36,200 USING DIFFERENT STRATEGIES, 1025 00:46:36,200 --> 00:46:38,280 USING CLASS 2 FUSIONS PROTEINS 1026 00:46:38,280 --> 00:46:43,240 AND CELLS WITH A DISTINCT 1027 00:46:43,240 --> 00:46:45,160 MECHANISM INCLUDINGENTERO 1028 00:46:45,160 --> 00:46:47,240 VIRUSES AND NORO VIRUSES AND 1029 00:46:47,240 --> 00:46:50,680 WHERE WE CAN WE APPLY THE SAME 1030 00:46:50,680 --> 00:46:53,520 STRATEGY OF DESIGN TO APPROACH 1031 00:46:53,520 --> 00:46:55,240 ANTIBODY DISCOVERY AND VACCINE 1032 00:46:55,240 --> 00:46:56,040 DEVELOPMENT. 1033 00:46:56,040 --> 00:46:59,960 I WILL SHARE NOW TODAY THE VRC 1034 00:46:59,960 --> 00:47:02,320 CONDUCTS RESEARCH ON THE TEN 1035 00:47:02,320 --> 00:47:05,160 VIRAL FAMILIES THAT ARE 1036 00:47:05,160 --> 00:47:08,640 PRIORITIZED BY THE PATHOGEN 1037 00:47:08,640 --> 00:47:13,280 PLAN THAT WAS INVITED IN THE 1038 00:47:13,280 --> 00:47:13,600 PLAN. 1039 00:47:13,600 --> 00:47:16,840 BUT VRC DOES A WILL THE MORE 1040 00:47:16,840 --> 00:47:18,000 THAN JUST VIROLOGY. 1041 00:47:18,000 --> 00:47:24,880 WE WORK ON TB AND MALARIA AS 1042 00:47:24,880 --> 00:47:25,280 MENTIONED. 1043 00:47:25,280 --> 00:47:29,120 A GREAT INTEREST IN ANTICANCER 1044 00:47:29,120 --> 00:47:31,520 T SHELLS USING NANOPARTICLE 1045 00:47:31,520 --> 00:47:36,840 VACCINES THAT INCLUDE CANCER 1046 00:47:36,840 --> 00:47:37,640 PEPTIDES AND AGONANTS. 1047 00:47:37,640 --> 00:47:39,440 THE CENTER HAS QUITE A FEW 1048 00:47:39,440 --> 00:47:48,200 PROGRAMS THAT TOUCH ON 1049 00:47:48,200 --> 00:47:48,840 FUNDAMENTAL PRINCIPLES AND 1050 00:47:48,840 --> 00:47:54,560 THERE IS A LOT OF DEVELOPMENT 1051 00:47:54,560 --> 00:48:00,000 THAT ALLOW US TO APPROACH 1052 00:48:00,000 --> 00:48:05,720 VACCINE FORMS AND ANTIBODY 1053 00:48:05,720 --> 00:48:06,240 DISCOVERIES. 1054 00:48:06,240 --> 00:48:10,040 SO BEFORE I GET INTO ADVANCES 1055 00:48:10,040 --> 00:48:11,640 OF OUR DISCOVERY SCIENCE, I 1056 00:48:11,640 --> 00:48:13,800 WOULD LIKE TO STOP FOR A FEW 1057 00:48:13,800 --> 00:48:18,400 MENTION AND INTRODUCE YOU TO 1058 00:48:18,400 --> 00:48:19,400 THE VRC CAPABILITIES. 1059 00:48:19,400 --> 00:48:23,000 BUILDING 40 IS WHERE A LOT OF 1060 00:48:23,000 --> 00:48:24,160 THESE DISCOVERY-BASED RESEARCH 1061 00:48:24,160 --> 00:48:28,440 OF THE VRC IS CONDUCTED, BOTH 1062 00:48:28,440 --> 00:48:31,320 BASIC SCIENCE AND 1063 00:48:31,320 --> 00:48:32,120 TRANSLATIONALLY FOCUSED 1064 00:48:32,120 --> 00:48:32,480 PROBLEMS. 1065 00:48:32,480 --> 00:48:35,000 SOME OF THOSE DISCOVERIES 1066 00:48:35,000 --> 00:48:36,920 RESULTS IN CONCEPTS THAT MAY 1067 00:48:36,920 --> 00:48:39,400 BE DEVELOPED AS PRODUCTS. 1068 00:48:39,400 --> 00:48:40,640 THAT PRODUCT DEVELOPMENT IS 1069 00:48:40,640 --> 00:48:45,560 DONE BY THE VACCINE PRO 1070 00:48:45,560 --> 00:48:50,680 PRODUCTION LABORATORY IN 1071 00:48:50,680 --> 00:48:52,200 GAITHERSBURG BY INVESTIGATORS 1072 00:48:52,200 --> 00:48:54,240 WHO HAVE A UNIQUE SKILLS SET 1073 00:48:54,240 --> 00:48:57,920 FOR THAT TYPE OF WORK. 1074 00:48:57,920 --> 00:49:00,280 THE PRODUCT INVOLVING 1075 00:49:00,280 --> 00:49:00,920 MANUFACTURING, PILOT PLAN, 1076 00:49:00,920 --> 00:49:03,280 THAT IS UP IN MARYLAND. 1077 00:49:03,280 --> 00:49:05,240 THIS ENABLES THE HUMAN 1078 00:49:05,240 --> 00:49:06,880 CLINICAL TRIALS PROGRAM IN 1079 00:49:06,880 --> 00:49:09,280 COLLABORATION WITH OUR 1080 00:49:09,280 --> 00:49:11,120 PARTNERS AT NIAID. 1081 00:49:11,120 --> 00:49:13,240 THE VACCINE IMMUNOLOGY PROGRAM 1082 00:49:13,240 --> 00:49:16,360 OR VIP IS THE GROUP WITHIN PRC 1083 00:49:16,360 --> 00:49:18,320 THEN CHARGED WITH 1084 00:49:18,320 --> 00:49:19,560 CHARACTERIZING AND ANALYZING 1085 00:49:19,560 --> 00:49:30,320 THE OUTPUT OF THOSE CLINICAL 1086 00:49:30,320 --> 00:49:31,280 TRIALS USING QUALIFIED EVENTS. 1087 00:49:31,280 --> 00:49:34,040 I WANT TO SHOW YOU THE SLIDE 1088 00:49:34,040 --> 00:49:37,520 OF THE TEAM THAT DOES THIS 1089 00:49:37,520 --> 00:49:40,840 WORK MAKING THE CONTRIBUTION 1090 00:49:40,840 --> 00:49:42,720 BOTH IN BUILDING 40, BUILDING 1091 00:49:42,720 --> 00:49:48,840 10 UP IN GAITHERSBURG WHERE 1092 00:49:48,840 --> 00:49:52,480 THEY ARE LOCATED. 1093 00:49:52,480 --> 00:49:53,560 SO INTRODUCED VRC'S PRODUCT 1094 00:49:53,560 --> 00:49:55,600 DEVELOPMENT CAPABILITIES IN 1095 00:49:55,600 --> 00:49:58,400 THIS CIRCLE, THE LIMITATION OF 1096 00:49:58,400 --> 00:49:59,360 THIS DEPICTION WILL SUGGEST 1097 00:49:59,360 --> 00:50:01,200 YOU DO ONE THING, THEN HAND IT 1098 00:50:01,200 --> 00:50:03,840 OFF TO THE NEXT GROUP IN THE 1099 00:50:03,840 --> 00:50:06,160 VRC AND SO ON AND SO FORTH BUT 1100 00:50:06,160 --> 00:50:07,880 THIS HELPS YOU UNDERSTAND HOW 1101 00:50:07,880 --> 00:50:10,400 THE VRC IS CONNECTED AND IT IS 1102 00:50:10,400 --> 00:50:12,120 THESE CONNECTIONS THAT IS 1103 00:50:12,120 --> 00:50:13,480 REQUIRED FOR SUCCESS IN 1104 00:50:13,480 --> 00:50:14,880 PRODUCT DEVELOPMENT. 1105 00:50:14,880 --> 00:50:17,040 THESE CONNECTIONS FORM BEFORE 1106 00:50:17,040 --> 00:50:20,120 THE VRC DECIDES TO TRANSLATE A 1107 00:50:20,120 --> 00:50:21,600 DISCOVERY IN THE LAB INTO THE 1108 00:50:21,600 --> 00:50:22,440 PRODUCT DEVELOPMENT PROGRAM 1109 00:50:22,440 --> 00:50:23,960 AND THEY EXIST ALL THE WAY 1110 00:50:23,960 --> 00:50:28,680 THROUGH THE END OF A CLINICAL 1111 00:50:28,680 --> 00:50:30,320 TRIAL ANALYSIS WITH THAT WORK. 1112 00:50:30,320 --> 00:50:32,800 SO THIS IS CRITICAL FOR OUR 1113 00:50:32,800 --> 00:50:33,400 MISSION. 1114 00:50:33,400 --> 00:50:35,120 SO THE LAST FOUR MONTHS SINCE 1115 00:50:35,120 --> 00:50:37,840 I JOINED THE VRC, ONE OF THE 1116 00:50:37,840 --> 00:50:41,880 MANY THINGS I HAVE LEARNED IS 1117 00:50:41,880 --> 00:50:42,480 REALLY HOW HARD PRODUCT 1118 00:50:42,480 --> 00:50:50,800 DEVELOPMENT IS AND THAT'S THE 1119 00:50:50,800 --> 00:50:53,440 MANUFACTURE THAT HAS ITS OWN 1120 00:50:53,440 --> 00:50:54,920 STORY, HAS ITS OWN SCIENTIFIC 1121 00:50:54,920 --> 00:50:58,560 PROBLEMS YOU HAVE TO SOLVE. 1122 00:50:58,560 --> 00:51:00,600 SO THE SCIENTIFIC PROBLEMS OF 1123 00:51:00,600 --> 00:51:04,280 THE VACCINE AND PPO ARE A 1124 00:51:04,280 --> 00:51:07,600 CRITICAL PART OF GETTING OUR 1125 00:51:07,600 --> 00:51:08,520 MISSION POLITIC ACCOMPLISHED 1126 00:51:08,520 --> 00:51:12,240 BECAUSE THEY ARE CHANGED WITH 1127 00:51:12,240 --> 00:51:13,840 THESE PROBLEMS. 1128 00:51:13,840 --> 00:51:16,240 THIS IS A MULTIDISCIPLINARY 1129 00:51:16,240 --> 00:51:17,400 TEAM OF INVESTIGATORS THAT 1130 00:51:17,400 --> 00:51:21,040 WORK IN THIS SPACE AND I HAVE 1131 00:51:21,040 --> 00:51:25,320 DEPICTED HERE PAPERS IN -- 1132 00:51:25,320 --> 00:51:28,120 PUBLISHED IN THE LAST YEAR 1133 00:51:28,120 --> 00:51:29,760 THAT DESCRIBE SOLVING PROBLEMS 1134 00:51:29,760 --> 00:51:31,960 TO MAKE FUTURE MANUFACTURING 1135 00:51:31,960 --> 00:51:33,840 RELATED THINGS WORK MORE 1136 00:51:33,840 --> 00:51:34,240 EXCLUSIVELY. 1137 00:51:34,240 --> 00:51:36,480 AND YOU KNOW THESE ARE NOT 1138 00:51:36,480 --> 00:51:39,680 PERHAPS DEPENDING ON HOW YOU 1139 00:51:39,680 --> 00:51:40,840 MEASURE THE HIGHEST IMPACT 1140 00:51:40,840 --> 00:51:43,600 PAPERS THAT THE VRC HAS 1141 00:51:43,600 --> 00:51:45,520 PUBLISHED IN THE LAST YEAR BUT 1142 00:51:45,520 --> 00:51:46,920 THEY ARE NO LESS IMPORTANT AND 1143 00:51:46,920 --> 00:51:48,640 I WANT TO TAKE JUST THIS 1144 00:51:48,640 --> 00:51:50,160 MOMENT TO HIGHLIGHT THIS WORK 1145 00:51:50,160 --> 00:51:53,560 AND THE TEAM THAT DOES THIS 1146 00:51:53,560 --> 00:52:04,160 CRITICAL PART OF THE MISSION. 1147 00:52:14,400 --> 00:52:17,440 SO NEXT I WILL DISCUSS A 1148 00:52:17,440 --> 00:52:23,880 COUPLE OF OTHER THINGS AT THE 1149 00:52:23,880 --> 00:52:25,400 H VRC. 1150 00:52:25,400 --> 00:52:28,120 THIS APPROACH IS GROUNDED ON 1151 00:52:28,120 --> 00:52:30,960 STRUCTURAL VIROLOGY THAT WAS 1152 00:52:30,960 --> 00:52:33,960 LED INITIALLY BY PETER QUONG 1153 00:52:33,960 --> 00:52:37,080 AS MENTIONED, NOW A LARGE TEAM 1154 00:52:37,080 --> 00:52:39,840 OF STRUCTURAL BIOLOGISTS THAT 1155 00:52:39,840 --> 00:52:41,560 ATTRIBUTE TO A WIDE RANGE OF 1156 00:52:41,560 --> 00:52:43,640 PROGRAMS IN THIS DIRECTION. 1157 00:52:43,640 --> 00:52:46,280 THE GUIDING PRINCIPLE IS 1158 00:52:46,280 --> 00:52:48,840 STRUCTURAL VIROLOGY AND 1159 00:52:48,840 --> 00:52:53,720 LEARNING IN THIS CASE FROM THE 1160 00:52:53,720 --> 00:52:56,320 G21 PATRIOT TEEN, A LOT OF 1161 00:52:56,320 --> 00:52:58,080 THIS COMES -- PROTEIN, A LOT 1162 00:52:58,080 --> 00:53:03,480 OF THIS COMES FROM RECOGNIZING 1163 00:53:03,480 --> 00:53:04,800 THE ANTIBODIES ACTIVITY. 1164 00:53:04,800 --> 00:53:07,960 SO ABOUT TEN YEARS AGO OR SO, 1165 00:53:07,960 --> 00:53:10,480 THE QUONG LAB PUBLISHED A 1166 00:53:10,480 --> 00:53:16,120 PAPER IN SCIENCE THAT 1167 00:53:16,120 --> 00:53:23,600 DISCOVERED A HIGH GPT FUSION 1168 00:53:23,600 --> 00:53:26,240 WORK OF HIV AND IF YOU CREATE 1169 00:53:26,240 --> 00:53:28,440 A VACCINE THAT ELICITED 1170 00:53:28,440 --> 00:53:30,040 ANTIBODIES IN THIS SPACE, YOU 1171 00:53:30,040 --> 00:53:34,080 COULD MAKE A VACCINE WITH 1172 00:53:34,080 --> 00:53:36,880 GREAT THREAT SO WE TESTED THIS 1173 00:53:36,880 --> 00:53:37,920 IDEA THROUGH PRODUCT 1174 00:53:37,920 --> 00:53:39,960 DEVELOPMENT AND CLINICAL AND 1175 00:53:39,960 --> 00:53:40,920 NONCLINICAL SCIENCE BUT THE 1176 00:53:40,920 --> 00:53:43,000 IDEA AND WHAT WE ARE WORKING 1177 00:53:43,000 --> 00:53:49,720 ON HERE IS TO PRIME 1178 00:53:49,720 --> 00:53:52,000 INDIVIDUALS WITH FUSION 1179 00:53:52,000 --> 00:53:55,680 PEPTIDES AS A CONJUGANT AND 1180 00:53:55,680 --> 00:53:58,480 BOOST WITH PRIMERS THAT HAVE 1181 00:53:58,480 --> 00:54:04,320 BEEN STABILIZED USING 1182 00:54:04,320 --> 00:54:06,840 STRUCTURAL INGENUITY AND THE 1183 00:54:06,840 --> 00:54:11,920 FINDING OF THIS IS THERE WAS A 1184 00:54:11,920 --> 00:54:12,960 RESPONSE OF OBTAINING 1185 00:54:12,960 --> 00:54:14,440 ANTIBODIES AGAINST THE 1186 00:54:14,440 --> 00:54:16,720 PEPTIDES THAT ARE THE THREAT 1187 00:54:16,720 --> 00:54:18,920 BUT IT IS A SIGNIFICANT 1188 00:54:18,920 --> 00:54:20,320 FINDING IN THIS SPACE. 1189 00:54:20,320 --> 00:54:23,240 AND IT IS HARD BUT WE'RE 1190 00:54:23,240 --> 00:54:32,280 DISCOVERING WHAT ARE THE 1191 00:54:32,280 --> 00:54:34,800 ANDOGENS, AND OTHER PARTS OF 1192 00:54:34,800 --> 00:54:35,320 THIS. 1193 00:54:35,320 --> 00:54:36,960 BUT RECOGNIZING THE PROBLEMS 1194 00:54:36,960 --> 00:54:40,280 WE SOLVE HERE, OF COURSE THE 1195 00:54:40,280 --> 00:54:41,920 QUONG GROUP AS WELL AS THE 1196 00:54:41,920 --> 00:54:44,120 CHAIN CALL TRIALS TEAM, THIS 1197 00:54:44,120 --> 00:54:46,600 BIG NETWORK I DESCRIBED ON 1198 00:54:46,600 --> 00:54:48,400 THAT VERY COMPLEX SLIDE A FEW 1199 00:54:48,400 --> 00:54:50,040 MOMENTS AGO. 1200 00:54:50,040 --> 00:54:52,200 IN THIS STUDY WHAT WE 1201 00:54:52,200 --> 00:54:53,280 DISCOVERED IS NONCLINICAL AS 1202 00:54:53,280 --> 00:54:56,680 WELL AS THE CLINICAL STUDY 1203 00:54:56,680 --> 00:54:59,520 REVEALED WHEN YOU IMMUNIZE 1204 00:54:59,520 --> 00:55:02,400 HUMANS WITH THE RESPONSE THE 1205 00:55:02,400 --> 00:55:03,560 PA*PBLT OGEN FINDS THE 1206 00:55:03,560 --> 00:55:04,680 PARTICLE YOU DIDN'T WANT TO 1207 00:55:04,680 --> 00:55:05,520 LOOK AT. 1208 00:55:05,520 --> 00:55:07,160 AND IN GRAY THERE IS THE FACE 1209 00:55:07,160 --> 00:55:08,640 OF THE PRIMER THAT OTHERWISE 1210 00:55:08,640 --> 00:55:12,000 WOULD BE IN CONTACT WITH THE 1211 00:55:12,000 --> 00:55:12,480 MEMBRANE. 1212 00:55:12,480 --> 00:55:14,560 THE IMMUNE SYSTEM DOESN'T 1213 00:55:14,560 --> 00:55:17,000 NORMALLY SEE THIS. 1214 00:55:17,000 --> 00:55:25,040 THIS IS NOW A IMMUNE -- IMMUNO 1215 00:55:25,040 --> 00:55:26,640 ANTIDOTE AND THAT INTRODUCES 1216 00:55:26,640 --> 00:55:28,120 ANOTHER PROBLEM AND ANOTHER 1217 00:55:28,120 --> 00:55:30,280 SET OF THINGS THAT WE CAN DO 1218 00:55:30,280 --> 00:55:33,400 SO WHAT THE VRC IS TRYING TO 1219 00:55:33,400 --> 00:55:35,720 DO IS DEVELOP A SERIES OF 1220 00:55:35,720 --> 00:55:37,600 STRATEGIES TO HIDE THAT BASE 1221 00:55:37,600 --> 00:55:39,320 OF PRIMERS FROM THE IMMUNE 1222 00:55:39,320 --> 00:55:41,600 RESPONSE AND SOME OF OUR 1223 00:55:41,600 --> 00:55:43,320 PROGRESS IS SHOWN HERE ON THE 1224 00:55:43,320 --> 00:55:45,200 PAPER ON THE RIGHT SO WE CAN 1225 00:55:45,200 --> 00:55:51,080 DO THAT AND NOW ARE EVALUATING 1226 00:55:51,080 --> 00:55:56,120 HOW THOSE IMMUNOGENS WORK IN A 1227 00:55:56,120 --> 00:55:57,160 NONCLINICAL PROCESS. 1228 00:55:57,160 --> 00:55:58,920 BUT I WILL STATE THERE IS 1229 00:55:58,920 --> 00:56:04,520 EVIDENCE THAT THE STRATEGY OF 1230 00:56:04,520 --> 00:56:12,040 PRIMING WITH PRIME -- FUSION 1231 00:56:12,040 --> 00:56:13,840 PEPTIDE CONJUGANTS WILL RESULT 1232 00:56:13,840 --> 00:56:15,960 IN FINDING ANTIBODIES AND IN 1233 00:56:15,960 --> 00:56:18,240 THE PAPER, IT DESCRIBES 1234 00:56:18,240 --> 00:56:22,720 IMMUNIZATION WITH JUST PRIMER 1235 00:56:22,720 --> 00:56:25,000 IMMUNOGENS AND LOOKING WITHIN 1236 00:56:25,000 --> 00:56:29,840 THE BODIES DESPITE THE 1237 00:56:29,840 --> 00:56:35,000 ANTIBODIES AND DISCOVERING 1238 00:56:35,000 --> 00:56:35,520 FUSION' HIS 1239 00:56:35,520 --> 00:56:39,400 >> -- ELICITED BY THE PRIMER 1240 00:56:39,400 --> 00:56:42,280 SO THAT IS A LOT BUT WE ARE 1241 00:56:42,280 --> 00:56:44,400 INTERESTED IN PURSUING THIS 1242 00:56:44,400 --> 00:56:45,640 EXPERIMENTAL MEDICINE, I 1243 00:56:45,640 --> 00:56:45,960 GUESS. 1244 00:56:45,960 --> 00:56:47,400 ANOTHER AREA THAT IS 1245 00:56:47,400 --> 00:56:52,280 CRITICALLY IMPORTANT FOR 1246 00:56:52,280 --> 00:57:00,360 HIV -- EXCUSE ME FOR VRC AND 1247 00:57:00,360 --> 00:57:01,560 HIV ANTIBODIES, MANY YEARS AGO 1248 00:57:01,560 --> 00:57:12,080 THERE WAS A PROVING BOARD 1249 00:57:15,600 --> 00:57:19,000 STUDY FOR THE DISEASE IN 1250 00:57:19,000 --> 00:57:20,680 INDIVIDUALS THAT WOULD PROVIDE 1251 00:57:20,680 --> 00:57:23,720 CONSIDERABLE DEGREE OF 1252 00:57:23,720 --> 00:57:25,000 PROTECTION IN HUMANS AND THIS 1253 00:57:25,000 --> 00:57:27,200 SORT OF GIVES US THE MARK TO 1254 00:57:27,200 --> 00:57:27,480 HIT. 1255 00:57:27,480 --> 00:57:30,000 THE MARK TO HIT WOULD BE BELOW 1256 00:57:30,000 --> 00:57:32,160 THE DOTTED LINE IN TERMS OF 1257 00:57:32,160 --> 00:57:34,360 POTENCY AND THE IDEA IS SINGLE 1258 00:57:34,360 --> 00:57:37,240 ANTIBODIES OR A COMBINATION OF 1259 00:57:37,240 --> 00:57:39,000 ANTIBODIES THAT GETS YOU BELOW 1260 00:57:39,000 --> 00:57:41,160 THAT LINE COULD BE OF VALUE 1261 00:57:41,160 --> 00:57:48,240 AND WE'RE WORKING CLOSELY WITH 1262 00:57:48,240 --> 00:57:50,000 DADE'S NETWORKS TO TEST THIS 1263 00:57:50,000 --> 00:57:52,720 IDEA BUT WE'RE ALSO HEAVILY 1264 00:57:52,720 --> 00:57:54,120 INVESTED IN DISCOVERY SCIENCE 1265 00:57:54,120 --> 00:58:03,000 TO IDENTIFY TWO TYPES OF 1266 00:58:03,000 --> 00:58:03,720 ANTIBODIES TO DEVELOP TOOLS TO 1267 00:58:03,720 --> 00:58:04,400 UNDERSTAND HOW BEST TO MEASURE 1268 00:58:04,400 --> 00:58:05,440 THEIR ACTIVITY IN NONCLINICAL 1269 00:58:05,440 --> 00:58:07,840 MODELS AND THEN TO IMPROVE 1270 00:58:07,840 --> 00:58:09,200 EXISTING ANTIBODIES TO EITHER 1271 00:58:09,200 --> 00:58:17,680 MAKE THEM MORE POTENT OR TO 1272 00:58:17,680 --> 00:58:18,360 TWEPBT THEM IN -- TO PRESENT 1273 00:58:18,360 --> 00:58:23,560 THEM IN WAYS THAT WOULD 1274 00:58:23,560 --> 00:58:24,400 INCREASE THEIR FUNCTIONALITY 1275 00:58:24,400 --> 00:58:29,080 MENTIONED IN Dr. 1276 00:58:29,080 --> 00:58:31,040 AUCHINCLOSS' REMARKS. 1277 00:58:31,040 --> 00:58:39,960 SO THE ANTIBODIES AND HI CURE, 1278 00:58:39,960 --> 00:58:45,520 THE CB TEST RESTING WITH HIV 1279 00:58:45,520 --> 00:58:45,800 CELLS. 1280 00:58:45,800 --> 00:58:48,280 THE RESERVOIR IS VERY SMALL 1281 00:58:48,280 --> 00:58:50,480 AND THERE IS NO DISTINCT 1282 00:58:50,480 --> 00:59:01,040 FEATURE BETWEEN A T-CELL AND 1283 00:59:03,200 --> 00:59:03,760 ANOTHER SO THIS IS PUBLISHED 1284 00:59:03,760 --> 00:59:06,240 IN A PAPER WHERE THEY 1285 00:59:06,240 --> 00:59:09,040 DEVELOPED THE TECHNIQUE THAT 1286 00:59:09,040 --> 00:59:11,640 ALLOWS THEM TO -- 1287 00:59:11,640 --> 00:59:13,480 [ AUDIO CUTTING OUT ] 1288 00:59:13,480 --> 00:59:17,560 -- THAT SORTS THEM IN HI DNA 1289 00:59:17,560 --> 00:59:22,040 IN THIS POCKET OF ELSE AND 1290 00:59:22,040 --> 00:59:22,640 THEY DO TRANSCRIPTIONAL 1291 00:59:22,640 --> 00:59:24,040 ANALYSIS OF WHAT IS GOING ON 1292 00:59:24,040 --> 00:59:26,600 IN THE CELLS AS THEY TRANSPORT 1293 00:59:26,600 --> 00:59:29,880 IT AND THESE STUDIES HAVE AND 1294 00:59:29,880 --> 00:59:32,160 WILL CONTINUE TO ILLUMINATE 1295 00:59:32,160 --> 00:59:34,600 THE STRUCTURE OF CELLS AND 1296 00:59:34,600 --> 00:59:36,000 LATENCY AND CELL SURVIVAL. 1297 00:59:36,000 --> 00:59:37,480 TOGETHER THESE TWO ISSUES MAY 1298 00:59:37,480 --> 00:59:39,800 HELP US BETTER UNDERSTAND WHAT 1299 00:59:39,800 --> 00:59:41,280 MAINTAINS OR ESTABLISHES 1300 00:59:41,280 --> 00:59:42,400 LATENCY AND INFORMED 1301 00:59:42,400 --> 00:59:44,960 STRATEGIES TO WAKE UP THOSE 1302 00:59:44,960 --> 00:59:48,120 LATENT VIRUSES AS PART OF 1303 00:59:48,120 --> 00:59:52,320 THOSE STRATEGIES. 1304 00:59:52,320 --> 00:59:53,760 SO Dr. AUCHINCLOSS COVERED 1305 00:59:53,760 --> 00:59:54,240 THIS WELL. 1306 00:59:54,240 --> 00:59:57,680 CERTAINLY AT THE VRC, THERE 1307 00:59:57,680 --> 01:00:03,400 WAS GREAT EXCITEMENT WATCHING 1308 01:00:03,400 --> 01:00:04,040 THE PATHOGEN. 1309 01:00:04,040 --> 01:00:07,000 BART GRAHAM WAS A CRITICALLY 1310 01:00:07,000 --> 01:00:09,440 IMPORTANT PART OF THE VRC 1311 01:00:09,440 --> 01:00:10,920 DESPITE HIS RETIREMENT AND 1312 01:00:10,920 --> 01:00:14,480 THIS WORK REALLY PROVIDED, I 1313 01:00:14,480 --> 01:00:17,000 THINK, A VERY CLEAR ACTIONABLE 1314 01:00:17,000 --> 01:00:19,640 STRATEGY FOR TAKING WHAT YOU 1315 01:00:19,640 --> 01:00:22,400 LEARN IN ONE CONTEXT WHICH WAS 1316 01:00:22,400 --> 01:00:24,960 STABILIZING HIV IN THE RIGHT 1317 01:00:24,960 --> 01:00:27,040 CONFIRMATION AND APPLYING IT 1318 01:00:27,040 --> 01:00:29,400 TO STABILIZING THE APPROPRIATE 1319 01:00:29,400 --> 01:00:30,800 CONFIRMATION OF RSV. 1320 01:00:30,800 --> 01:00:32,680 THAT WAS THEN THE SAME 1321 01:00:32,680 --> 01:00:34,800 STRATEGY THAT HE AND HIS TEAM 1322 01:00:34,800 --> 01:00:35,320 USED FOR COVID. 1323 01:00:35,320 --> 01:00:37,840 SO YOU WILL SEE THIS TEAM WITH 1324 01:00:37,840 --> 01:00:41,160 OTHER THINGS THAT WE DO AT THE 1325 01:00:41,160 --> 01:00:43,080 VRC, AND HAVE ALREADY. 1326 01:00:43,080 --> 01:00:46,320 BUT IN ADDITION TO THE 1327 01:00:46,320 --> 01:00:47,840 STRUCTURAL BASED ELEMENTS OF 1328 01:00:47,840 --> 01:00:49,800 THIS, WE CONTINUE TO STUDY HOW 1329 01:00:49,800 --> 01:00:54,000 IT WORKS AND THIS VERY NICE 1330 01:00:54,000 --> 01:00:55,840 STUDY BY TRACY, WHAT HE HAS 1331 01:00:55,840 --> 01:00:59,360 DONE IS DEMONSTRATE THE 1332 01:00:59,360 --> 01:01:02,080 PREFUSION STABILIZED VACCINE 1333 01:01:02,080 --> 01:01:04,480 DO INDEED GENERATE A SUPERIOR 1334 01:01:04,480 --> 01:01:06,800 YOUR B CELL AND ANTIBODY 1335 01:01:06,800 --> 01:01:09,760 RESPONSE THAT IS ASSOCIATED 1336 01:01:09,760 --> 01:01:12,120 WITH NEUTRALIZATION AND 1337 01:01:12,120 --> 01:01:14,960 PROTECTION AND THESE 1338 01:01:14,960 --> 01:01:16,520 IMMUNOLODGIC CORRELATES ARE 1339 01:01:16,520 --> 01:01:17,480 VERY IMPORTANT BECAUSE THEY 1340 01:01:17,480 --> 01:01:19,000 INFORM THE NEXT SET OF 1341 01:01:19,000 --> 01:01:21,400 PROBLEMS THAT WE'RE WORKING 1342 01:01:21,400 --> 01:01:22,080 ON. 1343 01:01:22,080 --> 01:01:24,000 AND EXAMPLES OF THOSE PROGRAMS 1344 01:01:24,000 --> 01:01:32,320 INCLUDE A MIX OF VIRUSES SUCH 1345 01:01:32,320 --> 01:01:35,000 AS PIB1-4, NEPA VIRUS, AND WE 1346 01:01:35,000 --> 01:01:40,040 HAVE DESIGNS FIRST AND IN SOME 1347 01:01:40,040 --> 01:01:40,800 CASE SECOND GENERATIONS 1348 01:01:40,800 --> 01:01:42,080 DESIGNS IN THOSE APPLICATIONS 1349 01:01:42,080 --> 01:01:46,600 TO TRY AND ADDRESS A LARGER 1350 01:01:46,600 --> 01:01:49,400 AND LARGER FRACTIONION OF 1351 01:01:49,400 --> 01:01:51,480 STKHAELS HAVE THESE SYSTEMS. 1352 01:01:51,480 --> 01:01:53,760 SO MAKING COMMENTS ABOUT FLU, 1353 01:01:53,760 --> 01:01:57,440 THE VRC IS HEAVILY VESTED IN 1354 01:01:57,440 --> 01:02:00,840 MAKING A SUPERIOR MORE BROADLY 1355 01:02:00,840 --> 01:02:03,800 ACCEPTED VACCINE FOR FLU. 1356 01:02:03,800 --> 01:02:10,120 THE PORTFOLIO FOCUS ON TWO 1357 01:02:10,120 --> 01:02:11,560 DIFFERENT TYPES OF THE 1358 01:02:11,560 --> 01:02:12,000 APPROACHES. 1359 01:02:12,000 --> 01:02:17,680 THE FIRST IS A FERRITIN 1360 01:02:17,680 --> 01:02:19,720 NANOPARTICLE AND THAT ALLOWS 1361 01:02:19,720 --> 01:02:25,320 YOU TO PRESENT THE HH PRIMERS. 1362 01:02:25,320 --> 01:02:28,400 AND THIS PROGRAM HAS BEEN 1363 01:02:28,400 --> 01:02:30,360 MOVING FOR SOMETIME AS YOU CAN 1364 01:02:30,360 --> 01:02:33,120 SEE IN THE SLIDE AND THESE 1365 01:02:33,120 --> 01:02:34,600 MOLECULES, MANY OF THEM HAVE 1366 01:02:34,600 --> 01:02:36,120 BEEN MANUFACTURED AND WE ARE 1367 01:02:36,120 --> 01:02:46,600 NOW LEARNING ABOUT THE 1368 01:02:49,880 --> 01:02:51,720 ACTIVITY OF THOSE WE'RE VERY 1369 01:02:51,720 --> 01:02:53,240 EXCITED THAT WE WERE ABLE TO 1370 01:02:53,240 --> 01:02:55,080 PARTICIPATE IN THE PROGRAM AND 1371 01:02:55,080 --> 01:02:57,680 ONE OF THOSE WERE IN A 1372 01:02:57,680 --> 01:03:01,560 CLINICAL TRIAL TODAY AND THE 1373 01:03:01,560 --> 01:03:12,120 SUBUNIT DELIVERED BY RNA SO 1374 01:03:12,800 --> 01:03:16,080 THAT IS LEADING TO THE 1375 01:03:16,080 --> 01:03:17,200 FINDINGS WE HAVE TODAY. 1376 01:03:17,200 --> 01:03:20,640 SO THIS IS PROJECT, THE INNER 1377 01:03:20,640 --> 01:03:23,200 CORE AND YOU PASS ON THE 1378 01:03:23,200 --> 01:03:23,560 MOLECULES. 1379 01:03:23,560 --> 01:03:25,160 THERE ARE TWO VERSIONS OF THAT 1380 01:03:25,160 --> 01:03:25,840 WE HAVE MADE. 1381 01:03:25,840 --> 01:03:27,520 THERE ARE OTHER IDEAS THAT ARE 1382 01:03:27,520 --> 01:03:32,880 IN PROGRESS THAT WOULD ALLOW 1383 01:03:32,880 --> 01:03:36,320 YOU TO MAKE MULTIVAILANT 1384 01:03:36,320 --> 01:03:43,600 VACCINES AND AS WAS MENTIONED, 1385 01:03:43,600 --> 01:03:45,040 OUR PV2 IS NOW IN CLINIC. 1386 01:03:45,040 --> 01:03:46,640 I WANT TO SHOW YOU THIS 1387 01:03:46,640 --> 01:03:48,960 BECAUSE THIS IS WHAT THE 1388 01:03:48,960 --> 01:03:49,800 SCIENCE LOOKS LIKE. 1389 01:03:49,800 --> 01:03:51,800 THIS IS A INTERESTING SET OF 1390 01:03:51,800 --> 01:03:52,600 EXPERIMENTS AND FIRST ON THE 1391 01:03:52,600 --> 01:03:55,360 LEFT YOU CAN SEE THE STRATEGY 1392 01:03:55,360 --> 01:03:58,080 REQUIRED TO MANUFACTURE FIVE 1393 01:03:58,080 --> 01:04:03,840 THINGS TO INCLUDE MASB1 AND 1394 01:04:03,840 --> 01:04:04,520 TPWHARS THE VACCINE -- 1395 01:04:04,520 --> 01:04:05,600 UNDERSTAND HOW THE VACCINE 1396 01:04:05,600 --> 01:04:09,480 LOOKS LIKE AND WHAT THE IMMUNE 1397 01:04:09,480 --> 01:04:14,640 RESPONSES ARE FOR WHAT YOU 1398 01:04:14,640 --> 01:04:16,680 MANUFACTURED. 1399 01:04:16,680 --> 01:04:24,640 AND WHAT IS THE TECHNOLOGY AND 1400 01:04:24,640 --> 01:04:26,800 THIS WILL HELP US UNDERSTAND 1401 01:04:26,800 --> 01:04:28,000 HOW THE MANUFACTURING 1402 01:04:28,000 --> 01:04:29,000 TECHNOLOGIES WORK WITH A 1403 01:04:29,000 --> 01:04:31,080 DIFFERENT LEVEL OF PRECISION 1404 01:04:31,080 --> 01:04:32,680 BUT ALSO PROVIDE INTERESTING 1405 01:04:32,680 --> 01:04:42,000 WAYS TO CORRELATE VACCINE 1406 01:04:42,000 --> 01:04:44,400 RESPONSES AND THE FORMAT AND 1407 01:04:44,400 --> 01:04:44,880 COMPOSITION. 1408 01:04:44,880 --> 01:04:49,000 THE PAST YEAR, WE HAD THREE 1409 01:04:49,000 --> 01:04:49,560 EXCITING STUDIES. 1410 01:04:49,560 --> 01:04:54,080 ON THE LEFT, A STUDY BY ONE 1411 01:04:54,080 --> 01:04:57,040 GROUP AND NHPS THAT SHOW IF 1412 01:04:57,040 --> 01:05:00,880 YOU TAKE A NANOPARTICLE 1 1413 01:05:00,880 --> 01:05:02,600 AGAINST FLU AND PUT THEM IN 1414 01:05:02,600 --> 01:05:03,880 THE SAME ANIMAL, YOU GET 1415 01:05:03,880 --> 01:05:07,040 PROTECTION AND THIS IS A BROAD 1416 01:05:07,040 --> 01:05:08,200 ELEMENTSMENT THAT SUPPORTS THE 1417 01:05:08,200 --> 01:05:13,000 CONCEPT THAT WE CAN PUT A HIV 1418 01:05:13,000 --> 01:05:14,360 STEM ON A NANOPARTICLE AND 1419 01:05:14,360 --> 01:05:17,320 PRESENT THAT IN A WAY THAT 1420 01:05:17,320 --> 01:05:20,480 GENERATES IMMUNE RESPONSES 1421 01:05:20,480 --> 01:05:21,000 THAT ARE PROTECTED. 1422 01:05:21,000 --> 01:05:26,200 ON THE RIGHT, TWO STUDIES THAT 1423 01:05:26,200 --> 01:05:26,920 CAME OUT IN THE SAME JOURNAL, 1424 01:05:26,920 --> 01:05:27,560 THE FIRST ON CLINICAL TRIAL 1425 01:05:27,560 --> 01:05:32,720 PROGRAMS ON THE VRC THAT 1426 01:05:32,720 --> 01:05:35,200 DEMONSTRATES A NANOPARTICLE 1427 01:05:35,200 --> 01:05:37,160 INJECTED IN A HUMAN IS SAFE 1428 01:05:37,160 --> 01:05:39,680 AND DID YOURABLE AND A SECOND 1429 01:05:39,680 --> 01:05:42,000 STUDY LED BY SARAH ANDREWS 1430 01:05:42,000 --> 01:05:45,080 GROUP AT THE VRC, WHAT HER 1431 01:05:45,080 --> 01:05:47,240 GROUP IS DOING IS SUBJECTING 1432 01:05:47,240 --> 01:05:49,880 THE ANIMAL RESPONSES TO THESE 1433 01:05:49,880 --> 01:05:51,720 VACCINES AND WHAT HE HAS SHOWN 1434 01:05:51,720 --> 01:05:56,760 IS THE IMMUNIZATION IS FOCUSED 1435 01:05:56,760 --> 01:05:59,760 ON TWO EPITOPES IN THE STEM, A 1436 01:05:59,760 --> 01:06:03,600 RED ONE AND A BLUE ONE TWO, 1437 01:06:03,600 --> 01:06:07,320 THIRDS UNDERLYING THE RED 1438 01:06:07,320 --> 01:06:08,000 EPITOPE AND ENCOURAGINGLY, 1439 01:06:08,000 --> 01:06:10,320 THOSE HAVE THE ABILITY TO 1440 01:06:10,320 --> 01:06:11,600 NEUTRALIZE MULTIPLE MEMBERS OF 1441 01:06:11,600 --> 01:06:16,280 THE SAME GROUP SO GROUP 1 1442 01:06:16,280 --> 01:06:19,400 REACTIVE ANTIBODIES. 1443 01:06:19,400 --> 01:06:26,280 THE ANCHOR IS JUST THE APALGUS 1444 01:06:26,280 --> 01:06:27,800 IMMUNOGEN IN THE VACCINE SO 1445 01:06:27,800 --> 01:06:31,040 YOU ARE GETTING AN INCREASED 1446 01:06:31,040 --> 01:06:34,760 RESOLUTION ON THE RESPONSE OF 1447 01:06:34,760 --> 01:06:37,160 THE VACCINE AND ENENABLED US 1448 01:06:37,160 --> 01:06:40,480 TO MAKE VACCINES WITH 1449 01:06:40,480 --> 01:06:41,000 INCREASING BREADTH. 1450 01:06:41,000 --> 01:06:45,960 AND THEN I WANT TO SHARE TWO 1451 01:06:45,960 --> 01:06:50,320 MORE VIN NETS -- VIGNETTES. 1452 01:06:50,320 --> 01:06:53,080 THESE ARE TWO MORE ADVISE, 1453 01:06:53,080 --> 01:06:55,880 CLASS 2 FUSION PROTEIN WHICH 1454 01:06:55,880 --> 01:07:00,480 INCLUDE THINGS LIKE CHICKEN 1455 01:07:00,480 --> 01:07:01,600 BOULIA AND. 1456 01:07:01,600 --> 01:07:02,080 [INDISCERNIBLE] 1457 01:07:02,080 --> 01:07:05,680 SO MANY YEARS AGO IN 1458 01:07:05,680 --> 01:07:07,960 COLLABORATION WITH DIR, WORKED 1459 01:07:07,960 --> 01:07:12,720 TO DEVELOP A CHICKEN VIRUS 1460 01:07:12,720 --> 01:07:15,480 INTO A VACCINE, PHASE 1 1461 01:07:15,480 --> 01:07:17,240 CLINICAL STUDY CONDUCTED BY 1462 01:07:17,240 --> 01:07:20,080 VRC AND THEN STAGE 2 AND AS 1463 01:07:20,080 --> 01:07:23,960 WAS MENTIONED, THE PHASE 3 1464 01:07:23,960 --> 01:07:24,640 CLINICAL TRIALS AND BOTH OF 1465 01:07:24,640 --> 01:07:28,000 THESE PHASE 3 TRIALS ARE VERY 1466 01:07:28,000 --> 01:07:28,440 ENCOURAGING. 1467 01:07:28,440 --> 01:07:31,000 THAT BLUEPRINT OF WHAT MADE A 1468 01:07:31,000 --> 01:07:34,280 GOOD CHICK VACCINE, THE VRC 1469 01:07:34,280 --> 01:07:36,320 DEVELOPED THREE DIFFERENT 1470 01:07:36,320 --> 01:07:44,440 VACCINES THAT ADDRESSED THREE 1471 01:07:44,440 --> 01:07:47,160 DIFFERENTEN -- DIFFERENT 1472 01:07:47,160 --> 01:07:50,080 ENCEPALYTIC VACCINES AND EACH 1473 01:07:50,080 --> 01:07:57,680 OF THEM CAN MAKE NEUTRALIZING 1474 01:07:57,680 --> 01:07:59,480 ANTIBODY VACCINES. 1475 01:07:59,480 --> 01:08:06,320 SO THEN MARIO ROTORS MADE A 1476 01:08:06,320 --> 01:08:07,720 VACCINE THAT RECRUITS 1477 01:08:07,720 --> 01:08:09,880 VOLUNTEERS AND FISHED OUT THE 1478 01:08:09,880 --> 01:08:11,160 ANTIBODIES FROM THOSE 1479 01:08:11,160 --> 01:08:11,560 VOLUNTEERS. 1480 01:08:11,560 --> 01:08:16,080 AND IN DOING THAT, YOU CAN SEE 1481 01:08:16,080 --> 01:08:18,240 HERE THE ANTIBODY THAT CAN 1482 01:08:18,240 --> 01:08:19,080 NEUTRALIZE ALL THREE VIRUSES 1483 01:08:19,080 --> 01:08:24,160 AND THERE IS A MOLECULE THAT 1484 01:08:24,160 --> 01:08:25,320 HAS VERY INTERESTING 1485 01:08:25,320 --> 01:08:27,120 DEVELOPMENT THAT WE'RE 1486 01:08:27,120 --> 01:08:27,880 CONSIDERING FURTHER. 1487 01:08:27,880 --> 01:08:30,760 THIS IS A VIRUS THAT DOES NOT 1488 01:08:30,760 --> 01:08:32,920 HAVE ENTRY MACHINERY LIKE THE 1489 01:08:32,920 --> 01:08:34,680 OTHER VIRUSES DESCRIBED. 1490 01:08:34,680 --> 01:08:35,760 THIS IS A NONENVELOPE VIRUS 1491 01:08:35,760 --> 01:08:40,080 LIKE POLE WROTE VIRUS AND LIKE 1492 01:08:40,080 --> 01:08:42,560 POLIO VIRUS, INFECTION OF 1493 01:08:42,560 --> 01:08:43,600 ADOLESCENTS AND CHILDREN CAN 1494 01:08:43,600 --> 01:08:49,760 RESULT IN A VERY DEBILITATING 1495 01:08:49,760 --> 01:08:50,760 PARALYTIC SYNDROME. 1496 01:08:50,760 --> 01:08:52,680 THE EPDEEM I DON'T GO OF THIS 1497 01:08:52,680 --> 01:08:55,920 IS INTERESTING, NOT FULLY 1498 01:08:55,920 --> 01:08:57,600 UNDERSTOOD, IT HAPPENS EVERY 1499 01:08:57,600 --> 01:09:01,240 YEAR AND REQUIRES A COUNTER 1500 01:09:01,240 --> 01:09:02,040 MEASURE. 1501 01:09:02,040 --> 01:09:06,080 JUST BEFORE COVID, TRACY, 1502 01:09:06,080 --> 01:09:08,360 BARNEY AND OTHERS AT VRC BEGAN 1503 01:09:08,360 --> 01:09:13,680 THINKING ABOUT HOW TO DEAL 1504 01:09:13,680 --> 01:09:14,320 WITH THIS. 1505 01:09:14,320 --> 01:09:24,840 DEVELOPED A STRAT DETO TAKE 1506 01:09:32,960 --> 01:09:33,440 FOUR PIECES AND MAKE A 1507 01:09:33,440 --> 01:09:34,120 PARTICLE IN THE LAB THAT LOOKS 1508 01:09:34,120 --> 01:09:34,800 STRUCTURALLY LIKE THE VIRUS 1509 01:09:34,800 --> 01:09:35,480 AND DEMONSTRATES THIS PARTICLE 1510 01:09:35,480 --> 01:09:37,680 IMMUNOGEN IS PROTECTED IN 1511 01:09:37,680 --> 01:09:41,600 MULTIPLE CLINICAL MODELS AND 1512 01:09:41,600 --> 01:09:42,240 THE VRC IS NOW WORKING ON 1513 01:09:42,240 --> 01:09:42,920 STRATEGIES TO MANUFACTURE THIS 1514 01:09:42,920 --> 01:09:43,480 FOR A HUMAN STUDY. 1515 01:09:43,480 --> 01:09:46,240 AND I WANT TO END WITH MALARIA 1516 01:09:46,240 --> 01:09:52,000 JUST TO EMPHASIZE WHAT Dr. 1517 01:09:52,000 --> 01:09:53,320 AUCHINCLOSS MENTIONED IS WE 1518 01:09:53,320 --> 01:09:56,040 HAVE VERY EXCITING SERIES OF 1519 01:09:56,040 --> 01:09:58,920 DISCOVERIES RELATING TO THE 1520 01:09:58,920 --> 01:10:00,960 ANTIBODIES WITH THE PROTEIN 1521 01:10:00,960 --> 01:10:11,200 AND THESE ARE PROTECTIVE IN 1522 01:10:11,200 --> 01:10:12,240 HUMANS. 1523 01:10:12,240 --> 01:10:18,920 THESE WERE CHALLENGED IN THE 1524 01:10:18,920 --> 01:10:20,520 FIELD OF DIR. 1525 01:10:20,520 --> 01:10:22,720 WE'RE VERY VESTED IN THIS 1526 01:10:22,720 --> 01:10:23,120 PROGRAM. 1527 01:10:23,120 --> 01:10:24,920 THIS INCLUDES, YOU KNOW, WE'RE 1528 01:10:24,920 --> 01:10:28,360 CONTINUING TO TRY AND OPTIMIZE 1529 01:10:28,360 --> 01:10:32,000 THESE MOLECULES FOR GREATER 1530 01:10:32,000 --> 01:10:38,640 POTENCY WHICH WOULD TRANSLATE 1531 01:10:38,640 --> 01:10:39,720 INTO THESE GOODS. 1532 01:10:39,720 --> 01:10:41,040 THESE TWO POINTS RELATE TO THE 1533 01:10:41,040 --> 01:10:43,560 CHALLENGES AND THEY ARE 1534 01:10:43,560 --> 01:10:44,640 SIGNIFICANT IN IDENTIFYING 1535 01:10:44,640 --> 01:10:46,040 COMMERCIAL PARTNERS THAT WILL 1536 01:10:46,040 --> 01:10:47,960 HELP US GET THIS TO THE FIELD. 1537 01:10:47,960 --> 01:10:55,160 AND THERE IS CLINICAL 1538 01:10:55,160 --> 01:10:59,800 EVALUATION ONGOING WITH PETE 1539 01:10:59,800 --> 01:11:00,480 CROMPTON'S GROUP. 1540 01:11:00,480 --> 01:11:05,840 THIS IS VERY EXCITING WITH THE 1541 01:11:05,840 --> 01:11:09,240 NIH WITH A GREAT INTRAMURAL 1542 01:11:09,240 --> 01:11:14,000 PROGRAM RECOGNIZED BY A NUMBER 1543 01:11:14,000 --> 01:11:14,360 OF GROUPS. 1544 01:11:14,360 --> 01:11:17,080 SO JUST A FEW QUICK COMMENTS 1545 01:11:17,080 --> 01:11:17,720 ABOUT THE VRC. 1546 01:11:17,720 --> 01:11:22,480 I GUESS THE MOST DRAMATIC 1547 01:11:22,480 --> 01:11:26,400 THING THAT OCCURRED SINCE RICK 1548 01:11:26,400 --> 01:11:28,720 KALB PRESENTED THE COUNCIL 1549 01:11:28,720 --> 01:11:32,000 LAST FALL IS THE DIRECTOR IN 1550 01:11:32,000 --> 01:11:35,360 APRIL, VERY EXCITED TO BE AT 1551 01:11:35,360 --> 01:11:42,360 THE VRC AND CONTRIBUTE TO ITS 1552 01:11:42,360 --> 01:11:43,080 SCIENCE. 1553 01:11:43,080 --> 01:11:43,560 KOUP. 1554 01:11:43,560 --> 01:11:46,560 AND EXCITED TO SHOW YOU THIS 1555 01:11:46,560 --> 01:11:48,440 SCIENCE TODAY AND EXCITED TO 1556 01:11:48,440 --> 01:11:51,080 TACKLE WHAT THE VRC WILL WORK 1557 01:11:51,080 --> 01:11:56,360 ON TOMORROW WHICH IS A VERY 1558 01:11:56,360 --> 01:11:59,000 COLLABORATIVE INCREDIBLE GROUP 1559 01:11:59,000 --> 01:12:07,000 OF FOLKS AT VRC. 1560 01:12:07,000 --> 01:12:17,600 WE HAVE HAD OTHER DEPARTURES 1561 01:12:19,640 --> 01:12:28,280 AS WELL, ADRIAN MCDERMOTT 1562 01:12:28,280 --> 01:12:33,840 GOING TO JOIN SAM OFI AS 1563 01:12:33,840 --> 01:12:42,480 GLOBAL HEAD OF IMMUNOLOGY, 1564 01:12:42,480 --> 01:12:44,200 NANCY SULLIVAN DEPARTED TO 1565 01:12:44,200 --> 01:12:46,600 JOIN BOSTON UNIVERSITY AS 1566 01:12:46,600 --> 01:12:51,200 DIRECTOR OF NATIONAL EMERGING 1567 01:12:51,200 --> 01:12:57,160 INFECTION DISEASES AND RUTH 1568 01:12:57,160 --> 01:12:59,520 WOODWARD WHO DEPARTED AS A 1569 01:12:59,520 --> 01:12:59,960 VETERINARIAN. 1570 01:12:59,960 --> 01:13:05,880 SO THE NEXT FEW MONTHS, GATHER 1571 01:13:05,880 --> 01:13:06,560 YOUR TEAM AND START THINKING 1572 01:13:06,560 --> 01:13:08,520 ABOUT WHAT ARE THE NEXT REAL 1573 01:13:08,520 --> 01:13:09,200 PROBLEMS TO SOLVE AND WE DID 1574 01:13:09,200 --> 01:13:09,840 THAT IN EARLY MAY TO TALK 1575 01:13:09,840 --> 01:13:11,360 ABOUT THE KIND OF SCIENCE AND 1576 01:13:11,360 --> 01:13:13,560 KIND OF PROGRAMS WE NEED TO 1577 01:13:13,560 --> 01:13:14,760 INVEST AND REINVEST IN. 1578 01:13:14,760 --> 01:13:18,920 ABOUT A MONTH LATER, I POSTED 1579 01:13:18,920 --> 01:13:23,040 A RETREAT -- HOST A*ED RETREAT 1580 01:13:23,040 --> 01:13:25,120 FOR -- HOSTED A RETREAT FOR 1581 01:13:25,120 --> 01:13:25,960 THE VRC. 1582 01:13:25,960 --> 01:13:29,240 THIS WAS AN OPPORTUNITY TO 1583 01:13:29,240 --> 01:13:31,320 SHARE MY SCIENTIFIC VISION AND 1584 01:13:31,320 --> 01:13:32,360 APPROACHES TO ENERGY 1585 01:13:32,360 --> 01:13:33,480 INVESTMENT IN MENTORING AND 1586 01:13:33,480 --> 01:13:35,840 OUR ENVIRONMENT AT THE VRC 1587 01:13:35,840 --> 01:13:39,040 WHICH WAS REALLY GREAT AND 1588 01:13:39,040 --> 01:13:40,960 FULLY FANTASTIC TO GET THIS 1589 01:13:40,960 --> 01:13:42,600 GROUP OF PEOPLE IN ONE ROOM 1590 01:13:42,600 --> 01:13:43,680 AND FEEL THEIR ENERGY. 1591 01:13:43,680 --> 01:13:46,640 SO NOW WE ARE ACTIVELY DOING 1592 01:13:46,640 --> 01:13:49,720 THE HARD WORK OF RECRUITING 1593 01:13:49,720 --> 01:13:52,840 NEW FACULTY AND NEW PROGRAM 1594 01:13:52,840 --> 01:13:55,000 HEADS TO EXECUTE THOSE PLANS 1595 01:13:55,000 --> 01:13:56,520 AND I WILL REPORT ON THAT NEXT 1596 01:13:56,520 --> 01:13:58,160 TIME I HAVE THE CHANCE TO BE 1597 01:13:58,160 --> 01:14:05,720 HERE SO THANK YOU. 1598 01:14:05,720 --> 01:14:10,080 >> ARE THERE ANY QUESTIONS? 1599 01:14:10,080 --> 01:14:12,120 >> THAT WAS A REALLY LOVELY 1600 01:14:12,120 --> 01:14:14,760 TALK AND REALLY FUN TO SEE THE 1601 01:14:14,760 --> 01:14:16,120 PRODUCT DEVELOPMENT WORK IN 1602 01:14:16,120 --> 01:14:18,200 JUST THE AMOUNT OF CAPACITY 1603 01:14:18,200 --> 01:14:20,320 THAT EXISTS IN HOUSE AT THE 1604 01:14:20,320 --> 01:14:22,240 VRC AND THROUGH ALL THE 1605 01:14:22,240 --> 01:14:22,560 PHASES. 1606 01:14:22,560 --> 01:14:24,240 THE QUESTION IS GO OVER HOW 1607 01:14:24,240 --> 01:14:26,000 YOU INTERACT WITH THE PRIVATE 1608 01:14:26,000 --> 01:14:28,280 SECTOR WHEN IT COMES TO REALLY 1609 01:14:28,280 --> 01:14:30,360 BRINGING THESE THINGS FORWARD, 1610 01:14:30,360 --> 01:14:32,640 BOTH BRINGING THE PRODUCTS 1611 01:14:32,640 --> 01:14:34,440 THERE AND THEN PROTECTING THE 1612 01:14:34,440 --> 01:14:35,160 INVESTMENTS AMERICAN PEOPLE 1613 01:14:35,160 --> 01:14:37,680 HAVE MADE IN THIS PROGRAM. 1614 01:14:37,680 --> 01:14:38,720 >> YEAH, I WILL CONFESS RIGHT 1615 01:14:38,720 --> 01:14:41,240 AT THE FRONT THIS IS A GROWTH 1616 01:14:41,240 --> 01:14:44,200 AREA FOR ME AS A SCIENTIST 1617 01:14:44,200 --> 01:14:45,720 COMINGS INTO THIS VERY COCK 1618 01:14:45,720 --> 01:14:46,160 PLEX ROLE. 1619 01:14:46,160 --> 01:14:50,080 I WILL SHARE THAT THIS IS A 1620 01:14:50,080 --> 01:14:52,440 CHALLENGE SO A LOT OF THE 1621 01:14:52,440 --> 01:14:54,360 ACTIVITIES THAT HAVE RESULTED 1622 01:14:54,360 --> 01:14:57,280 IN THE VRC PRODUCTS ARE REALLY 1623 01:14:57,280 --> 01:14:59,400 COLLABORATIVE EXERCISES THAT 1624 01:14:59,400 --> 01:15:01,720 BEGAN REALLY BEFORE WITH THE 1625 01:15:01,720 --> 01:15:05,640 PRODUCT WHERE WE, THE VRC AND 1626 01:15:05,640 --> 01:15:10,760 THE PRIVATE SECTOR HAS SHARED 1627 01:15:10,760 --> 01:15:12,080 SCIENTIFIC INTEREST TO WORK 1628 01:15:12,080 --> 01:15:15,840 TOGETHER ON WHAT BECAME A 1629 01:15:15,840 --> 01:15:17,320 PRODUCT, VRC WOULD BE AN 1630 01:15:17,320 --> 01:15:18,040 EXAMPLE OF THAT. 1631 01:15:18,040 --> 01:15:20,880 SOME OF THE PRODUCTS THAT 1632 01:15:20,880 --> 01:15:23,720 EXIST ARE LICENSURE ACTIVITIES 1633 01:15:23,720 --> 01:15:25,680 THAT OCCURRED AFTER THE 1634 01:15:25,680 --> 01:15:28,920 SCIENCE WAS DONE AND THE 1635 01:15:28,920 --> 01:15:36,000 INTELLECTUAL PROPERTIES HERE 1636 01:15:36,000 --> 01:15:37,320 >>TO REENGAGE AND EXPLORING 1637 01:15:37,320 --> 01:15:38,800 WHAT POTENTIAL COLLABORATE 1638 01:15:38,800 --> 01:15:44,040 PREPARES FOUR FOR ALL OF OUR 1639 01:15:44,040 --> 01:15:44,840 PORTFOLIO, WHAT SCIENTIFIC 1640 01:15:44,840 --> 01:15:45,920 INTERESTS WE SHARE TO SEE 1641 01:15:45,920 --> 01:15:48,000 WHERE WE CAN WORK TOGETHER. 1642 01:15:48,000 --> 01:15:50,560 THIS HAS BEEN AN INTERESTING 1643 01:15:50,560 --> 01:15:52,280 AND ENJOYABLE OPPORTUNITY IN 1644 01:15:52,280 --> 01:15:53,960 THE LAST FOUR MONTHS TO MEET A 1645 01:15:53,960 --> 01:15:58,000 LOT OF NEW PEOPLE WHO BRING 1646 01:15:58,000 --> 01:15:59,720 OPERATIONAL CAPABILITIES TO 1647 01:15:59,720 --> 01:16:00,960 NIAID AND THE SCIENCE WE DO. 1648 01:16:00,960 --> 01:16:02,120 BUT I WOULD SAY THIS IS 1649 01:16:02,120 --> 01:16:03,880 DIFFICULT AND THERE IS NO 1650 01:16:03,880 --> 01:16:06,080 BETTER EXAMPLE THAN BRINGING 1651 01:16:06,080 --> 01:16:07,640 FORWARD SOMETHING AS EXCITING 1652 01:16:07,640 --> 01:16:10,360 AS AN BODY THAT WILL PROTECT 1653 01:16:10,360 --> 01:16:11,800 PEOPLE FROM MALARIA AND WE 1654 01:16:11,800 --> 01:16:13,800 JUST NEED TO GET ACROSS THAT 1655 01:16:13,800 --> 01:16:21,400 GAP OF AMAZING SCIENCE, 1656 01:16:21,400 --> 01:16:22,160 AMAZING CLINICAL DATA. 1657 01:16:22,160 --> 01:16:24,480 AND PARTNER IN LICENSING AND 1658 01:16:24,480 --> 01:16:32,000 MANUFACTURING MATERIAL THAT 1659 01:16:32,000 --> 01:16:32,760 COULD BE USED. 1660 01:16:32,760 --> 01:16:35,640 >>GREAT TALK AND JUST TO 1661 01:16:35,640 --> 01:16:39,240 FOLLOW UP, YOU HAVE SO MUCH 1662 01:16:39,240 --> 01:16:42,600 GOING ON THAT THE ANSWER OF 1663 01:16:42,600 --> 01:16:44,400 HOW TO INTERACT WITH 1664 01:16:44,400 --> 01:16:45,480 INDUSTRIES JUST NEEDS, I 1665 01:16:45,480 --> 01:16:47,640 THINK, SOME SORT OF NEW IDEA 1666 01:16:47,640 --> 01:16:50,240 BECAUSE IT IS TOO BIG TO DO 1667 01:16:50,240 --> 01:16:52,440 ONE AT A TIME. 1668 01:16:52,440 --> 01:16:53,640 WE HAVE ABOUT TEN PROGRAMS, 1669 01:16:53,640 --> 01:16:55,960 ALL OF WHICH HAVE THE 1670 01:16:55,960 --> 01:16:56,960 POSSIBILITY OF REALLY MOVING 1671 01:16:56,960 --> 01:16:58,480 THE NEEDLE FOR A SPECIFIC 1672 01:16:58,480 --> 01:17:00,120 DISEASE IN SOME PART OF THE 1673 01:17:00,120 --> 01:17:00,760 WORLD. 1674 01:17:00,760 --> 01:17:03,200 I DON'T HAVE A GOOD ANSWER. 1675 01:17:03,200 --> 01:17:07,320 I MEAN OBVIOUSLY I DON'T HAVE 1676 01:17:07,320 --> 01:17:10,200 THE ANSWER BUT IT'S, UM, LIKE 1677 01:17:10,200 --> 01:17:12,360 A BIG COMPANY WITH A LOT OF 1678 01:17:12,360 --> 01:17:15,760 PROGRAMS AND SOMEWHERE IN THE 1679 01:17:15,760 --> 01:17:19,080 NIH NEEDS TO HIRE OR BRING IN 1680 01:17:19,080 --> 01:17:22,880 PEOPLE WHO CAN MAKE THE 1681 01:17:22,880 --> 01:17:25,240 TRANSITION INTO GETTING A 1682 01:17:25,240 --> 01:17:26,560 PRODUCT OUT MORE EFFICIENT 1683 01:17:26,560 --> 01:17:28,880 THAN ONE AT A TIME AND WAITING 1684 01:17:28,880 --> 01:17:31,600 FOR PEOPLE TO KNOCK AT YOUR 1685 01:17:31,600 --> 01:17:32,160 DOOR. 1686 01:17:32,160 --> 01:17:38,160 >>THANKS FOR THE COMMENT. 1687 01:17:38,160 --> 01:17:40,760 THANKS FOR THE TERRIFIC 1688 01:17:40,760 --> 01:17:42,560 OVERVIEW OF PROGRESS IN SO 1689 01:17:42,560 --> 01:17:43,120 MANY DIFFERENT AREAS. 1690 01:17:43,120 --> 01:17:46,080 IN THE AREA OF RSV, YOU KNOW, 1691 01:17:46,080 --> 01:17:47,840 IT SEEMS LIKE WE'RE MOVING 1692 01:17:47,840 --> 01:17:50,560 FROM A TIME WHEN THERE WERE NO 1693 01:17:50,560 --> 01:17:51,280 VACCINES OR INTERVENTIONS TO 1694 01:17:51,280 --> 01:17:53,120 ONE WHERE YOU HAVE AT LEAST 1695 01:17:53,120 --> 01:17:56,400 THREE CHOICES WITH PREMATE 1696 01:17:56,400 --> 01:17:57,040 TALL. 1697 01:17:57,040 --> 01:18:00,080 POST NATAL AND POST NATIVE 1698 01:18:00,080 --> 01:18:01,480 ACTIVE AND PERHAPS MOVING INTO 1699 01:18:01,480 --> 01:18:03,840 A GROUP OF STUDIES OF 1700 01:18:03,840 --> 01:18:04,560 IMPLEMENTATION, YOU KNOW, WHAT 1701 01:18:04,560 --> 01:18:07,120 IS GOING TO BE THE BEST 1702 01:18:07,120 --> 01:18:09,200 STRATEGY FOR PREVENTING 1703 01:18:09,200 --> 01:18:11,440 DISEASE AND IT WILL VARY BY 1704 01:18:11,440 --> 01:18:12,520 INDIVIDUAL PATIENT, AGE, 1705 01:18:12,520 --> 01:18:15,160 WHATEVER, YOU HAVE ANY INSIGHT 1706 01:18:15,160 --> 01:18:18,080 AS TO THIS NEXT PHASE AND HOW 1707 01:18:18,080 --> 01:18:19,600 THOSE SORTS OF ISSUES WILL BE 1708 01:18:19,600 --> 01:18:20,160 SORTED OUT? 1709 01:18:20,160 --> 01:18:22,520 >>THAT IS A BIT BEYOND MY 1710 01:18:22,520 --> 01:18:23,080 EXPERTISE. 1711 01:18:23,080 --> 01:18:25,200 THAT IS NOT SOMETHING WE'RE 1712 01:18:25,200 --> 01:18:26,920 ENGAGED IN, THE COMPARISON OF 1713 01:18:26,920 --> 01:18:32,760 PRODUCTS AND HOW THEY MIGHT BE 1714 01:18:32,760 --> 01:18:34,680 BEST USED CLINICALLY. 1715 01:18:34,680 --> 01:18:36,800 >>SO VERY STIMULATING. 1716 01:18:36,800 --> 01:18:38,760 OBVIOUSLY YOUR FOCUS IS MOSTLY 1717 01:18:38,760 --> 01:18:41,520 ON VIRUSES BUT PLEASED TO SEE 1718 01:18:41,520 --> 01:18:43,280 THE MALARIA AND JUST WONDERING 1719 01:18:43,280 --> 01:18:47,760 IF THERE ARE CONSIDERATIONS 1720 01:18:47,760 --> 01:18:49,480 FOR THIS APPROACH OF 1721 01:18:49,480 --> 01:18:54,200 DISCUSSION FOR US ON NONVIRAL 1722 01:18:54,200 --> 01:18:55,400 INTRACELLULAR PATHOGENS AND 1723 01:18:55,400 --> 01:18:57,400 WHETHER THE STRUCTURE BASED 1724 01:18:57,400 --> 01:18:59,600 GUIDED APPROACH HAS INCREASED 1725 01:18:59,600 --> 01:19:02,360 COMPLEXITY BECAUSE MAYBE 1726 01:19:02,360 --> 01:19:03,520 THERE'S MULTIPLE INJURY 1727 01:19:03,520 --> 01:19:05,240 MECHANISMS AND THINGS LIKE 1728 01:19:05,240 --> 01:19:05,760 THAT. 1729 01:19:05,760 --> 01:19:08,120 AND SECOND AND MAYBE A MORE 1730 01:19:08,120 --> 01:19:10,520 COMPLEX QUESTION IS THERE 1731 01:19:10,520 --> 01:19:13,120 POTENTIAL FOR APPROACH FOR 1732 01:19:13,120 --> 01:19:14,560 POST INFECTION VACCINE 1733 01:19:14,560 --> 01:19:15,120 DEVELOPMENT? 1734 01:19:15,120 --> 01:19:19,120 >>SO THE FIRST PART IS THE 1735 01:19:19,120 --> 01:19:21,840 PROGRAMS AT CRC, AND THIS IS A 1736 01:19:21,840 --> 01:19:23,960 PROBLEM TO BE SOLVED, REFLECTS 1737 01:19:23,960 --> 01:19:26,560 A BIT OF STRATEGIC THINKING 1738 01:19:26,560 --> 01:19:29,040 ABOUT WHERE THERE IS A NEED SO 1739 01:19:29,040 --> 01:19:30,840 WE SOLVE THE MOST IMPORTANT 1740 01:19:30,840 --> 01:19:34,080 PROBLEM OF COURSE AND INTEREST 1741 01:19:34,080 --> 01:19:36,320 AND EXPERTISE OF PRINCIPLE 1742 01:19:36,320 --> 01:19:37,880 INVESTIGATORS THAT WILL DO THE 1743 01:19:37,880 --> 01:19:39,080 WORK AND SOLVE THE PROBLEMS. 1744 01:19:39,080 --> 01:19:41,360 AND TO GIVE YOU A SENSE OF WHY 1745 01:19:41,360 --> 01:19:44,080 WE'RE DOING SOME OF THE THINGS 1746 01:19:44,080 --> 01:19:47,160 WE'RE DOING, THAT'S REFLECTED 1747 01:19:47,160 --> 01:19:48,960 IN THE PORTFOLIO. 1748 01:19:48,960 --> 01:19:53,800 IN TERMS OF STRATEGIES FOR -- 1749 01:19:53,800 --> 01:19:56,160 THERAPEUTIC OR POST EXPOSURE 1750 01:19:56,160 --> 01:19:57,960 STRATEGIES, YOU KNOW, I THINK 1751 01:19:57,960 --> 01:20:00,080 ANTIBODIES ARE REALLY 1752 01:20:00,080 --> 01:20:00,440 EXCITING. 1753 01:20:00,440 --> 01:20:01,400 I STUDY ANTIBODIES IN THE 1754 01:20:01,400 --> 01:20:03,560 CONTEXT OF THE WORK THAT WE 1755 01:20:03,560 --> 01:20:04,120 DO. 1756 01:20:04,120 --> 01:20:05,880 I THINK ANTIBODIES HAS GREAT 1757 01:20:05,880 --> 01:20:08,080 POTENTIAL FOR SOME 1758 01:20:08,080 --> 01:20:10,800 APPLICATIONS AND THEN WHEN THE 1759 01:20:10,800 --> 01:20:13,480 PATIENTS OR OTHERS ARE GIVEN 1760 01:20:13,480 --> 01:20:14,680 IT, JUST DEPENDS ON THE 1761 01:20:14,680 --> 01:20:15,800 COMPLEXITY OF THE BUG YOU ARE 1762 01:20:15,800 --> 01:20:21,720 TRYING TO WORK ON, THE VIRUSES 1763 01:20:21,720 --> 01:20:23,440 OF WHICH MALARIA IS A BIG 1764 01:20:23,440 --> 01:20:24,320 ISSUE. 1765 01:20:24,320 --> 01:20:25,960 SO I THINK IT DEPENDS ON THE 1766 01:20:25,960 --> 01:20:27,480 TARGET AND WHAT OUR THINKING 1767 01:20:27,480 --> 01:20:29,880 IS BASED ON PURELY PREVENTION 1768 01:20:29,880 --> 01:20:36,640 OR SOMETHING THAT COULD WORK 1769 01:20:36,640 --> 01:20:41,960 THERAPEUTICALLY. 1770 01:20:41,960 --> 01:20:45,040 >>ALSO LOVE THE WORK OF THE 1771 01:20:45,040 --> 01:20:45,680 PASSIVE ADMINISTRATION OF 1772 01:20:45,680 --> 01:20:47,280 ANTIBODIES FOR SO MANY 1773 01:20:47,280 --> 01:20:48,520 APPLICATIONS AND I WONDER TO 1774 01:20:48,520 --> 01:20:50,480 WHAT DEGREE WE HAVE HAD A 1775 01:20:50,480 --> 01:20:53,320 TRIAL RUN OF THAT WITH THE 1776 01:20:53,320 --> 01:20:57,320 COVID PANDEMIC AND OF COURSE A 1777 01:20:57,320 --> 01:21:01,280 RELATIVELY SHORT HALF LIFE, 1778 01:21:01,280 --> 01:21:03,000 THINGS LIKE HIV, AIDS, WHAT 1779 01:21:03,000 --> 01:21:04,400 LESSONS YOU HAVE LEARNED FROM 1780 01:21:04,400 --> 01:21:05,080 THAT EXPERIENCE. 1781 01:21:05,080 --> 01:21:07,200 >>AS YOU SAID, IT REALLY 1782 01:21:07,200 --> 01:21:08,840 DEPENDS ON THE BIOLOGY AND 1783 01:21:08,840 --> 01:21:12,240 PRODUCT DEVELOPMENT AND 1784 01:21:12,240 --> 01:21:13,200 PERHAPS REFLECTS SOME 1785 01:21:13,200 --> 01:21:16,040 AWARENESS OF HOW THE VIRUS 1786 01:21:16,040 --> 01:21:18,640 WORKS WITH LIMITATIONS. 1787 01:21:18,640 --> 01:21:20,120 SO COVID, THE CHALLENGE IS 1788 01:21:20,120 --> 01:21:21,480 VARIATION AND THEREFORE YOU 1789 01:21:21,480 --> 01:21:23,680 HAVE TO HAVE MOLECULES THAT 1790 01:21:23,680 --> 01:21:26,720 EITHER ACCOMMODATE THE KNOWN 1791 01:21:26,720 --> 01:21:28,320 VARIATION OR TARGET SITES THAT 1792 01:21:28,320 --> 01:21:30,800 ARE NOT LIKELY TO VARY AT ALL. 1793 01:21:30,800 --> 01:21:33,120 THERE ARE CERTAINLY SOME 1794 01:21:33,120 --> 01:21:35,080 VIRUSES THAT FOR WHICH THIS IS 1795 01:21:35,080 --> 01:21:36,920 FAR LESS OF AN ISSUE. 1796 01:21:36,920 --> 01:21:39,680 THAT WOULD BE, I WOULD SAY, 1797 01:21:39,680 --> 01:21:41,040 EASIER TARGETS OF OPPORTUNITY 1798 01:21:41,040 --> 01:21:43,680 BUT STILL MAY HAVE PUBLIC 1799 01:21:43,680 --> 01:21:45,120 HEALTH IMPACTS TO ADDRESS. 1800 01:21:45,120 --> 01:21:46,680 WE CAN'T CHANGE THE VARIATION 1801 01:21:46,680 --> 01:21:49,160 OF THE VICE SO WE HAVE TO 1802 01:21:49,160 --> 01:21:53,480 EITHER FIND BETTER APTY BODIES 1803 01:21:53,480 --> 01:21:56,480 WITH GREATER BREADTH AND WE'RE 1804 01:21:56,480 --> 01:21:58,440 TRYING OR COMPLIMENT THAT WITH 1805 01:21:58,440 --> 01:22:01,840 MOLECULES THAT DO MULTIPLE 1806 01:22:01,840 --> 01:22:09,000 THINGS IN ONE SUCH AS. 1807 01:22:09,000 --> 01:22:12,400 >>I MUST ASK IS ANYONE AT THE 1808 01:22:12,400 --> 01:22:16,600 VRC LOOKING AT AGE RELATED 1809 01:22:16,600 --> 01:22:23,360 INFOCYTES AND HOW IT AFFECTS 1810 01:22:23,360 --> 01:22:23,960 TIDERS ON MEMORY? 1811 01:22:23,960 --> 01:22:27,200 >>NOT AT THIS TIME, NO. 1812 01:22:27,200 --> 01:22:28,080 >>THERE ARE NEW ANTIBODIES 1813 01:22:28,080 --> 01:22:30,560 THAT ARE ABLE TO PREDICT 1814 01:22:30,560 --> 01:22:33,080 BINDING AND NEW INDICATION 1815 01:22:33,080 --> 01:22:36,320 ALGORITHMS THAT YOU ARE ABLE 1816 01:22:36,320 --> 01:22:40,360 TO GET FAIRLY ACCURATE TYPING 1817 01:22:40,360 --> 01:22:42,680 OFF GWAS DATA SO IT MAY BE 1818 01:22:42,680 --> 01:22:45,680 OPENING THE FIELD TO LOOK AT 1819 01:22:45,680 --> 01:22:46,800 VACCINES' VARIABILITY BETWEEN 1820 01:22:46,800 --> 01:22:48,600 INDIVIDUALS AND THEIR TYPES 1821 01:22:48,600 --> 01:22:52,000 AND ABILITY TO PRESENT THE 1822 01:22:52,000 --> 01:22:52,520 ACTUAL PROTEINS. 1823 01:22:52,520 --> 01:22:53,800 >>YEAH, THANKS FOR THE 1824 01:22:53,800 --> 01:23:00,840 COMMENT, THAT IS VERY 1825 01:23:00,840 --> 01:23:01,240 INTERESTING. 1826 01:23:01,240 --> 01:23:03,080 >>THANK YOU VERY MUCH, 1827 01:23:03,080 --> 01:23:05,680 APPRECIATE IT. 1828 01:23:05,680 --> 01:23:07,760 >>THANK YOU. 1829 01:23:07,760 --> 01:23:11,120 >>BEFORE, BEFORE WE ADJOURN 1830 01:23:11,120 --> 01:23:12,920 FROM THIS OPEN SESSION, I JUST 1831 01:23:12,920 --> 01:23:15,720 WANT TO REMIND EVERYBODY THAT 1832 01:23:15,720 --> 01:23:16,960 THE ADVISORY COUNCIL MEETING 1833 01:23:16,960 --> 01:23:19,720 IN JANUARY HAS BEEN MOVED FROM 1834 01:23:19,720 --> 01:23:21,960 MONDAY JANUARY 29TH TO TUESDAY 1835 01:23:21,960 --> 01:23:22,880 JANUARY 30TH. 1836 01:23:22,880 --> 01:23:25,840 THAT WILL BE A VIRTUAL 1837 01:23:25,840 --> 01:23:26,240 MEETING. 1838 01:23:26,240 --> 01:23:28,040 WE DECIDED EVEN BEFORE THE 1839 01:23:28,040 --> 01:23:29,640 PANDEMIC THAT THE JANUARY 1840 01:23:29,640 --> 01:23:31,400 COUNCIL MEETING WILL ALWAYS BE 1841 01:23:31,400 --> 01:23:35,080 VIRTUAL JUST TO MAKE TRAVEL 1842 01:23:35,080 --> 01:23:35,440 EASIER. 1843 01:23:35,440 --> 01:23:41,040 I DID MENTION IN MY OPENING 1844 01:23:41,040 --> 01:23:42,240 REMARKS THAT JENNY MURRATTA'S 1845 01:23:42,240 --> 01:23:44,600 RIFLE HERE IN A FEW WEEKS 1846 01:23:44,600 --> 01:23:47,880 TAKING OVER AS DIRECTOR OF 1847 01:23:47,880 --> 01:23:50,720 NIAID WOULD START THE CLOCK 1848 01:23:50,720 --> 01:23:51,280 FOR ME. 1849 01:23:51,280 --> 01:23:53,320 I OFTEN SAID I WOULD OFFER SIX 1850 01:23:53,320 --> 01:23:55,080 MONTHS TO THE NEW DIRECTOR FOR 1851 01:23:55,080 --> 01:23:56,760 TRANSITION AND THAT WOULD BE 1852 01:23:56,760 --> 01:23:58,760 END OF MARCH NEXT YEAR TO STEP 1853 01:23:58,760 --> 01:23:59,600 DOWN FROM THIS POSITION. 1854 01:23:59,600 --> 01:24:01,720 SO THIS WILL BE THE LAST 1855 01:24:01,720 --> 01:24:02,680 IN-PERSON MEETING WITH THE 1856 01:24:02,680 --> 01:24:04,280 COUNCIL SINCE IT WILL BE 1857 01:24:04,280 --> 01:24:04,880 VIRTUAL IN JANUARY. 1858 01:24:04,880 --> 01:24:07,080 IT IS A PLEASURE TO WORK WITH 1859 01:24:07,080 --> 01:24:09,720 COUNCIL OVER THE COURSE OF 1860 01:24:09,720 --> 01:24:11,640 ALMOST 18 YEARS NOW. 1861 01:24:11,640 --> 01:24:13,920 THE MEETING WILL BE ADJOURNED 1862 01:24:13,920 --> 01:24:15,440 AND WE WILL GO TO CLOSED 1863 01:24:15,440 --> 01:24:17,640 SESSION IN ABOUT FIVE MINUTES. 1864 01:24:17,640 --> 01:24:19,000 WE ASK NONU.S. GOVERNMENT 1865 01:24:19,000 --> 01:24:20,640 PEOPLE TO PLEASE STEP OUT OF 1866 01:24:20,640 --> 01:24:22,520 THE ROOM WHILE WE'RE DOING 1867 01:24:22,520 --> 01:24:22,920 THAT. 1868 01:24:22,920 --> 01:24:23,960 THE FOUR PEOPLE RETIRING FROM 1869 01:24:23,960 --> 01:24:25,360 COUNCIL, COULD YOU MEET WITH 1870 01:24:25,360 --> 01:24:27,200 ME TO HAVE YOUR PICTURE TAKEN 1871 01:24:27,200 --> 01:24:28,800 AND RECEIVE YOUR PLAQUES 1872 01:24:28,800 --> 01:24:31,120 BECAUSE WE WANT TO HONOR YOUR 1873 01:24:31,120 --> 01:24:31,440 SERVICE. 1874 01:24:31,440 --> 01:24:33,880 SO THANK YOU VERY MUCH. 1875 01:24:33,880 --> 01:24:44,160 ADJOURNED.